PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22819818-5 2012 Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation. Phosphatidylcholines 0-19 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 109-114 22819818-5 2012 Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation. Phosphatidylcholines 0-19 tumor necrosis factor Mus musculus 118-127 22819818-5 2012 Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation. Phosphatidylcholines 0-19 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Mus musculus 168-205 22819818-5 2012 Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation. Phosphatidylcholines 0-19 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Mus musculus 207-213 22995497-7 2012 Finally, our measurements suggest an unexpectedly strong preferential enrichment of the anionic lipid phosphatidylglycerol around the cationic KALP peptide in ternary mixtures with PC. Phosphatidylcholines 181-183 anosmin 2, pseudogene Homo sapiens 143-147 22822086-2 2012 The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule. Phosphatidylcholines 205-224 phosphatidylinositol transfer protein alpha Homo sapiens 62-71 22822086-2 2012 The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule. Phosphatidylcholines 205-224 phosphatidylinositol transfer protein alpha Homo sapiens 73-79 22822086-2 2012 The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule. Phosphatidylcholines 205-224 phosphatidylinositol transfer protein beta Homo sapiens 85-93 22822086-2 2012 The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule. Phosphatidylcholines 205-224 phosphatidylinositol transfer protein beta Homo sapiens 95-101 22521809-4 2012 Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone. Phosphatidylcholines 129-148 microtubule associated protein tau Homo sapiens 74-77 22521809-4 2012 Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone. Phosphatidylcholines 129-148 keratin 19 Homo sapiens 84-87 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 94-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22706677-2 2012 We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages. Phosphatidylcholines 99-118 phospholipase A2 group X Homo sapiens 38-45 22706677-2 2012 We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages. Phosphatidylcholines 99-118 phospholipase A2 group X Homo sapiens 47-56 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 94-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 115-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 115-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22583846-2 2012 First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, solubility study, TEM, etc. Phosphatidylcholines 68-87 pulmonary surfactant-associated protein C Oryctolagus cuniculus 169-172 22791820-1 2012 In Arabidopsis thaliana, XIPOTL1 encodes a phosphoethanolamine N-methyltransferase with a central role in phosphatidylcholine biosynthesis via the methylation pathway. Phosphatidylcholines 106-125 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 25-32 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 39-44 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 84-89 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 22583846-2 2012 First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, solubility study, TEM, etc. Phosphatidylcholines 135-154 pulmonary surfactant-associated protein C Oryctolagus cuniculus 169-172 22539676-6 2012 Similarly to BSP proteins from other species, rec-BSPH1 bound to gelatin, heparin, phosphatidylcholine liposomes, and sperm. Phosphatidylcholines 83-102 binder of sperm protein homolog 1 Mus musculus 50-55 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 43-62 C-reactive protein Homo sapiens 85-103 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 43-62 C-reactive protein Homo sapiens 105-108 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 64-66 C-reactive protein Homo sapiens 85-103 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 64-66 C-reactive protein Homo sapiens 105-108 22683603-7 2012 Furthermore, when cyt c was associated with liposomes composed of cardiolipin/phosphatidylcholine, and incubated with RNA and H(2)O(2), it was found cross-linked with the oxidized RNA and dissociated from the liposome. Phosphatidylcholines 78-97 cytochrome c, somatic Homo sapiens 18-23 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines 91-110 apolipoprotein E Homo sapiens 78-83 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines 91-110 apolipoprotein E Homo sapiens 181-186 23075452-3 2012 While the cellular phosphatidylethanolamine (PE) content remained unaltered, cellular phosphatidylcholine (PC)-, LPC- and TG-contents were significantly increased upon EL overexpression. Phosphatidylcholines 86-105 lipase, endothelial Mus musculus 168-170 22465066-2 2012 In the present study we have re-evaluated lipid-protein interactions of SP-B by analysing Forster resonance energy transfer (FRET) efficiencies, obtained from time-resolved measurements, from the single tryptophan in SP-B to different fluorescently labelled phospholipids in matrix bilayers made of either pure phosphatidylcholine (POPC) or the full lipid extract obtained from purified surfactant. Phosphatidylcholines 311-330 surfactant protein B Homo sapiens 72-76 22465066-2 2012 In the present study we have re-evaluated lipid-protein interactions of SP-B by analysing Forster resonance energy transfer (FRET) efficiencies, obtained from time-resolved measurements, from the single tryptophan in SP-B to different fluorescently labelled phospholipids in matrix bilayers made of either pure phosphatidylcholine (POPC) or the full lipid extract obtained from purified surfactant. Phosphatidylcholines 332-336 surfactant protein B Homo sapiens 72-76 23075452-3 2012 While the cellular phosphatidylethanolamine (PE) content remained unaltered, cellular phosphatidylcholine (PC)-, LPC- and TG-contents were significantly increased upon EL overexpression. Phosphatidylcholines 107-109 lipase, endothelial Mus musculus 168-170 23075452-8 2012 Incorporation of [(3)H]-Choline into cellular PC was 56% lower in EL compared with LacZ cells, indicating decreased endogenous PC synthesis. Phosphatidylcholines 46-48 lipase, endothelial Mus musculus 66-68 23075452-10 2012 Based on our results, we conclude that EL not only supplies cells with FFA as found previously, but also with HDL-derived LPC and LPE species resulting in increased cellular TG and PC content as well as decreased endogenous PC synthesis. Phosphatidylcholines 123-125 lipase, endothelial Mus musculus 39-41 23075452-10 2012 Based on our results, we conclude that EL not only supplies cells with FFA as found previously, but also with HDL-derived LPC and LPE species resulting in increased cellular TG and PC content as well as decreased endogenous PC synthesis. Phosphatidylcholines 181-183 lipase, endothelial Mus musculus 39-41 22511767-3 2012 One key enzyme in the Lands" cycle is fatty acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT), which utilizes lysophosphatidylcholine (LysoPC) and fatty acyl-CoA to produce various phosphatidylcholine (PC) species. Phosphatidylcholines 57-76 lysophosphatidylcholine acyltransferase 3 Mus musculus 94-99 22511767-3 2012 One key enzyme in the Lands" cycle is fatty acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT), which utilizes lysophosphatidylcholine (LysoPC) and fatty acyl-CoA to produce various phosphatidylcholine (PC) species. Phosphatidylcholines 95-97 lysophosphatidylcholine acyltransferase 3 Mus musculus 44-92 22173044-5 2012 RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC). Phosphatidylcholines 176-195 phospholipase A2 group IIA Homo sapiens 13-18 22676268-0 2012 Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell. Phosphatidylcholines 0-19 lysophosphatidylcholine acyltransferase 1 Homo sapiens 33-39 22676268-2 2012 De-acylated lipids are then re-acylated by lysophospholipid acyltransferase enzymes such as LPCAT1 which catalyses the formation of phosphatidylcholine (PC) from lysoPC and long-chain acyl-CoA. Phosphatidylcholines 132-151 lysophosphatidylcholine acyltransferase 1 Homo sapiens 92-98 22173044-5 2012 RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC). Phosphatidylcholines 197-199 phospholipase A2 group IIA Homo sapiens 13-18 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 132-154 22494626-2 2012 Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins. Phosphatidylcholines 91-110 phospholipase A2 group IID Homo sapiens 6-14 22494626-2 2012 Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins. Phosphatidylcholines 91-110 phospholipase A2 group IIA Homo sapiens 6-13 22494626-2 2012 Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins. Phosphatidylcholines 112-114 phospholipase A2 group IID Homo sapiens 6-14 22494626-2 2012 Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins. Phosphatidylcholines 112-114 phospholipase A2 group IIA Homo sapiens 6-13 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 156-160 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 132-154 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 156-160 22647268-3 2012 It has been suggested that PC synthesis by PEMT plays an important role in the transport of polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) from the liver to plasma and possibly other tissues. Phosphatidylcholines 27-29 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 43-47 22407999-7 2012 Thereby, flow cytometry revealed high cellular association and internalization of anti-IGF1-R immunoliposomes (soy phosphatidylcholine (SPC)/cholesterol (Chol)-polyethyleneglycol (PEG)-1H7, 50.1+-2.2%). Phosphatidylcholines 115-134 insulin like growth factor 1 receptor Homo sapiens 87-93 22860206-6 2012 Among different phospholipids tested, choline- or ethanolamine-containing phospholipids showed potent effects, and 1 mM phosphatidylcholine increased NAAA activity by 6.6-fold. Phosphatidylcholines 120-139 N-acylethanolamine acid amidase Mus musculus 150-154 22403410-9 2012 Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 151-170 Ups1p Saccharomyces cerevisiae S288C 67-72 22403410-9 2012 Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 151-170 Ups2p Saccharomyces cerevisiae S288C 77-82 22430035-2 2012 We reconstituted the catalytic core of the human neutrophil NADPH oxidase, flavocytochrome b (Cyt b) in 99% phosphatidylcholine vesicles in order to correlate anionic lipid-dependent conformational changes in membrane-bound Cyt b and oxidase activity. Phosphatidylcholines 108-127 mitochondrially encoded cytochrome b Homo sapiens 94-99 22226181-11 2012 IMS revealed an abnormal accumulation of lysophosphatidylcholine (LPC; 1-acyl 16:0) and phosphatidylcholine (diacyl 16:0/20:4) in the VV intima and media. Phosphatidylcholines 45-64 annexin A1 Homo sapiens 66-72 22859919-4 2012 There are two mechanisms to protect the canalicular membrane from solubilization by bile salts; ABCB4 secretes phosphatidylcholine into bile to form mixed micelles with bile salts, and ATP8B1 maintains the canalicular membrane in a liquid-ordered state. Phosphatidylcholines 111-130 ATP binding cassette subfamily B member 4 Homo sapiens 96-101 22278967-1 2012 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 86-105 cut like homeobox 1 Homo sapiens 49-52 22015962-3 2012 Here we show that an unusual phosphatidylcholine species with two saturated 12 carbon fatty acid acyl sidechains (dilauroyl phosphatidylcholine (DLPC)) is an LRH-1 agonist ligand in vitro. Phosphatidylcholines 29-48 nuclear receptor subfamily 5, group A, member 2 Mus musculus 158-163 22015962-7 2012 These findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis. Phosphatidylcholines 43-62 nuclear receptor subfamily 5, group A, member 2 Mus musculus 27-32 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 27-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22101393-2 2012 D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC). Phosphatidylcholines 49-68 heparan sulfate proteoglycan 2 Homo sapiens 103-106 22101393-2 2012 D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC). Phosphatidylcholines 70-72 heparan sulfate proteoglycan 2 Homo sapiens 103-106 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 27-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22101976-0 2012 Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine. Phosphatidylcholines 95-114 catalase-3 Glycine max 36-44 22223861-4 2012 Lack of L-FABP selectively increased cholesterol, phospholipid (especially phosphatidylcholine), and branched-chain FA accumulation in the cholesterol-rich microdomains. Phosphatidylcholines 75-94 fatty acid binding protein 1 Homo sapiens 8-14 21822308-5 2012 The first enzyme of the phosphatidyl choline production pathway, CHKA, is overexpressed in many cancers, and the product of the enzyme, phosphocholine, is also increased in tumor cells. Phosphatidylcholines 24-44 choline kinase alpha Homo sapiens 65-69 23449275-7 2012 C-reactive protein showed positive correlations with phosphatidylcholine, phosphatidylserine, phosphatidylinositol and total phospholipids in membranes from control subjects. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 0-18 22167755-5 2012 We identified phosphatidylcholine (PCh) as the major phospholipid bound to human soluble EPCR (sEPCR). Phosphatidylcholines 14-33 protein C receptor Homo sapiens 89-93 22167755-5 2012 We identified phosphatidylcholine (PCh) as the major phospholipid bound to human soluble EPCR (sEPCR). Phosphatidylcholines 35-38 protein C receptor Homo sapiens 89-93 22167755-6 2012 PCh in EPCR could be exchanged for lysophosphatidylcholine (lysoPCh) and platelet activating factor (PAF). Phosphatidylcholines 0-3 protein C receptor Homo sapiens 7-11 22333571-0 2012 Distinction between phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) and phosphatidylinositol (PI)-specific phospolipase C (PI-PLC) needs clarification. Phosphatidylcholines 41-43 heparan sulfate proteoglycan 2 Homo sapiens 74-77 22308393-3 2012 Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively. Phosphatidylcholines 167-186 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 84-88 22358145-1 2012 The combination of data obtained from isothermal mixing calorimetry and light scattering allowed us to reveal the relationships between the character of the interactions of casein (beta-casein and sodium caseinate (SCN) particles) with phosphatidylcholine (PC) liposomes and their specific properties, such as, the hydrophilic-lipophilic balance of the surface properties, the size, and the architecture. Phosphatidylcholines 236-255 casein beta Homo sapiens 181-192 22184139-1 2012 The ATP-binding cassette transporter ABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous to the multidrug transporter ABCB1. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 4 Canis lupus familiaris 37-42 22184139-1 2012 The ATP-binding cassette transporter ABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous to the multidrug transporter ABCB1. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 1 Canis lupus familiaris 200-205 22070544-8 2012 LC-MS based lipidomic analysis identified significantly higher levels of phospholipids, especially phosphatidylcholines in GPAM protein positive tumors. Phosphatidylcholines 99-119 glycerol-3-phosphate acyltransferase, mitochondrial Homo sapiens 123-127 22308393-3 2012 Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively. Phosphatidylcholines 167-186 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 93-97 22308393-4 2012 Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS. Phosphatidylcholines 116-118 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 56-60 22308393-4 2012 Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS. Phosphatidylcholines 116-118 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 66-70 22308393-4 2012 Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS. Phosphatidylcholines 116-118 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 106-110 22101258-1 2012 BACKGROUND: Lysophosphatidylcholine acyltransferase 1 (LPCAT1), the enzyme catalyzing the reaction in remodeling of phosphatidylcholine (PC) has been reported to express in prostate. Phosphatidylcholines 16-35 lysophosphatidylcholine acyltransferase 1 Homo sapiens 55-61 22079326-3 2012 To investigate whether a reduced PC:PE ratio influences cellular growth and apoptosis, we utilized the MT58 cell line, which contains a thermo-sensitive mutation in CTP:phosphocholine cytidylyltransferase-alpha, the rate-limiting enzyme for PC biosynthesis. Phosphatidylcholines 241-243 choline-phosphate cytidylyltransferase A Cricetulus griseus 165-210 22101258-1 2012 BACKGROUND: Lysophosphatidylcholine acyltransferase 1 (LPCAT1), the enzyme catalyzing the reaction in remodeling of phosphatidylcholine (PC) has been reported to express in prostate. Phosphatidylcholines 56-58 lysophosphatidylcholine acyltransferase 1 Homo sapiens 12-53 22037357-8 2012 When supplemented into pure lipid vesicles and monomolecular films composed of PG and PC mixtures, SP-B also inhibited hydrolysis by both PLA2G1B and Group IIA sPLA2 (PLA2G2A). Phosphatidylcholines 86-88 surfactant protein B Bos taurus 99-103 22128164-10 2012 PAH1-encoded phosphatidate phosphatase catalyzes the penultimate step in triacylglycerol synthesis, and the diacylglycerol generated in the reaction may also be used for phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 170-189 phosphatidate phosphatase PAH1 Saccharomyces cerevisiae S288C 0-4 23049600-2 2012 This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy. Phosphatidylcholines 92-111 pumilio RNA binding family member 3 Homo sapiens 53-57 22679365-2 2012 METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA, leading to the formation of a thioether bond between free SH-groups of the polymer and maleimide groups of the liposome. Phosphatidylcholines 33-52 T-box transcription factor 1 Homo sapiens 126-129 21968070-3 2012 The accumulation of PUFAs in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine correlated with an induced lysophosphatidic acid acyltransferase (LPAAT)3 mRNA expression, increased microsomal LPAAT3 activity, and shift of LPAAT specificity to PUFA-coenzyme A. Phosphatidylcholines 29-48 1-acylglycerol-3-phosphate O-acyltransferase 3 Mus musculus 165-172 22679365-2 2012 METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA, leading to the formation of a thioether bond between free SH-groups of the polymer and maleimide groups of the liposome. Phosphatidylcholines 54-58 T-box transcription factor 1 Homo sapiens 126-129 21745592-2 2011 CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Phosphatidylcholines 106-108 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-40 22768255-7 2012 In particular, short chain saturated fatty acids and the phosphatidylcholine (PC) lipids into which these fatty acids are incorporated were specifically reduced by Nampt inhibition. Phosphatidylcholines 57-76 nicotinamide phosphoribosyltransferase Homo sapiens 164-169 22768255-7 2012 In particular, short chain saturated fatty acids and the phosphatidylcholine (PC) lipids into which these fatty acids are incorporated were specifically reduced by Nampt inhibition. Phosphatidylcholines 78-80 nicotinamide phosphoribosyltransferase Homo sapiens 164-169 22348006-4 2012 METHODOLOGY: We used isothermal titration calorimetry (ITC) and enzyme-linked immunosorbent assay (ELISA) to examine binding of Stx1 and Stx2 to various glycans, glycosphingolipids, and glycosphingolipid mixtures in the presence or absence of membrane components, phosphatidylcholine, and cholesterol. Phosphatidylcholines 264-283 syntaxin-2 Chlorocebus sabaeus 137-141 22348006-9 2012 In the presence of phosphatidylcholine and cholesterol, both Stx1 and Stx2 bound well to Gb3 or Gb4 alone or mixed with other neutral glycolipids. Phosphatidylcholines 19-38 syntaxin-2 Chlorocebus sabaeus 70-74 22348006-9 2012 In the presence of phosphatidylcholine and cholesterol, both Stx1 and Stx2 bound well to Gb3 or Gb4 alone or mixed with other neutral glycolipids. Phosphatidylcholines 19-38 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 89-92 22348006-10 2012 Pre-incubation with Gb3 in the presence of phosphatidylcholine and cholesterol neutralized Stx1, but not Stx2 toxicity to Vero cells. Phosphatidylcholines 43-62 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 20-23 21958442-0 2011 The role of glycerol and phosphatidylcholine in solubilizing and enhancing insulin stability in reverse hexagonal mesophases. Phosphatidylcholines 25-44 insulin Homo sapiens 75-82 21908590-0 2011 An albumin-associated PLA2-like activity inactivates surfactant phosphatidylcholine secreted from fetal type II pneumocytes. Phosphatidylcholines 64-83 phospholipase A2 group IIA Homo sapiens 22-26 21745592-2 2011 CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Phosphatidylcholines 106-108 cut-like homeobox 1 Mus musculus 82-85 22020259-9 2011 A similar BRSK1-activating effect was obtained with synthetic SMV made with phosphatidylcholine, cholesterol and sphingomyelin, mixed in the same molar ratio at which these three major lipids are present in rafts. Phosphatidylcholines 76-95 BR serine/threonine kinase 1 Homo sapiens 10-15 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 46-65 phosphatidylethanolamine N-methyltransferase Sus scrofa 87-131 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 46-65 phosphatidylethanolamine N-methyltransferase Sus scrofa 133-137 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 67-69 phosphatidylethanolamine N-methyltransferase Sus scrofa 87-131 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 67-69 phosphatidylethanolamine N-methyltransferase Sus scrofa 133-137 21958070-5 2011 By using enzymatic assays, we showed that the expression of PEMT increased the cellular PC content, lowered the PE content, but had no effect on the sphingomyelin content. Phosphatidylcholines 88-90 phosphatidylethanolamine N-methyltransferase Sus scrofa 60-64 21958070-6 2011 Consequently, PEMT expression led to reductions in PE/PC and sphingomyelin/PC ratios. Phosphatidylcholines 54-56 phosphatidylethanolamine N-methyltransferase Sus scrofa 14-18 21958070-6 2011 Consequently, PEMT expression led to reductions in PE/PC and sphingomyelin/PC ratios. Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Sus scrofa 14-18 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 11 Rattus norvegicus 158-179 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 11 Rattus norvegicus 181-185 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Rattus norvegicus 248-278 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Rattus norvegicus 280-284 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 215-234 ATP binding cassette subfamily B member 11 Rattus norvegicus 158-179 21703191-1 2011 BACKGROUND & AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2). Phosphatidylcholines 215-234 ATP binding cassette subfamily B member 11 Rattus norvegicus 181-185 22035958-0 2011 A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Phosphatidylcholines 20-39 sterol regulatory element binding transcription factor 1 Homo sapiens 12-19 22057011-4 2011 LDs of fld1Delta and WT cells exhibited similar phospholipid profiles, whereas LDs of cds1 and ino2Delta strains had a higher (cds1) or lower (ino2Delta) percentage of phosphatidylcholine than those of WT, respectively. Phosphatidylcholines 168-187 CDP-diacylglycerol synthase 1 Homo sapiens 86-90 21855891-2 2011 The main conclusions from our experimental data indicate that phosphatidylcholine monolayers (PC), in contrast to phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), were resistant to the hydrolysis by human intestinal sPLA2. Phosphatidylcholines 62-81 phospholipase A2 group X Homo sapiens 228-233 22078872-3 2011 (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. Phosphatidylcholines 105-124 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 46-51 22078872-3 2011 (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. Phosphatidylcholines 126-128 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 46-51 22035958-4 2011 Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation. Phosphatidylcholines 45-64 sterol regulatory element binding transcription factor 1 Homo sapiens 206-213 22035958-4 2011 Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation. Phosphatidylcholines 66-68 sterol regulatory element binding transcription factor 1 Homo sapiens 206-213 22035958-4 2011 Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation. Phosphatidylcholines 133-135 sterol regulatory element binding transcription factor 1 Homo sapiens 206-213 22035958-6 2011 Thus, nutritional or genetic conditions limiting SAMe or PC production may activate SREBP-1, contributing to human metabolic disorders. Phosphatidylcholines 57-59 sterol regulatory element binding transcription factor 1 Homo sapiens 84-91 21787361-8 2011 In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence. Phosphatidylcholines 87-106 lysophosphatidylcholine acyltransferase 2 Homo sapiens 75-81 21787361-8 2011 In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence. Phosphatidylcholines 87-106 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 186-223 21787361-8 2011 In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence. Phosphatidylcholines 87-106 lipase maturation factor 1 Mus musculus 286-289 21820390-11 2011 This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine. Phosphatidylcholines 162-181 transmembrane protein 30A Mus musculus 78-84 21820390-11 2011 This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine. Phosphatidylcholines 162-181 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 150-155 21846716-0 2011 Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. Phosphatidylcholines 101-120 ATP binding cassette subfamily A member 1 Homo sapiens 42-47 21846716-1 2011 Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Phosphatidylcholines 51-70 ATP binding cassette subfamily A member 1 Homo sapiens 34-39 21846716-1 2011 Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Phosphatidylcholines 51-70 apolipoprotein A1 Homo sapiens 148-154 21846716-1 2011 Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Phosphatidylcholines 51-70 apolipoprotein A1 Homo sapiens 183-189 21846716-3 2011 Interestingly, phosphatidylcholine (PtdCho) was selectively removed from nonraft domains by apoA-I, whereas sphingomyelin and cholesterol were desorbed from both detergent-resistant membranes and nonraft domains. Phosphatidylcholines 15-34 apolipoprotein A1 Homo sapiens 92-98 21846716-3 2011 Interestingly, phosphatidylcholine (PtdCho) was selectively removed from nonraft domains by apoA-I, whereas sphingomyelin and cholesterol were desorbed from both detergent-resistant membranes and nonraft domains. Phosphatidylcholines 36-42 apolipoprotein A1 Homo sapiens 92-98 21846716-7 2011 Finally, we obtained evidence that apoA-I interaction with ABCA1 promoted the activation and gene expression of key enzymes in the PtdCho biosynthesis pathway. Phosphatidylcholines 131-137 apolipoprotein A1 Homo sapiens 35-41 21846716-7 2011 Finally, we obtained evidence that apoA-I interaction with ABCA1 promoted the activation and gene expression of key enzymes in the PtdCho biosynthesis pathway. Phosphatidylcholines 131-137 ATP binding cassette subfamily A member 1 Homo sapiens 59-64 21880860-4 2011 The homogenates of COS-7 cells overexpressing recombinant A-C1s from human, mouse, and rat showed a phospholipase A1/2 (PLA1/2) activity toward phosphatidylcholine (PC). Phosphatidylcholines 144-163 phospholipase A2 group IB Rattus norvegicus 100-118 21880860-4 2011 The homogenates of COS-7 cells overexpressing recombinant A-C1s from human, mouse, and rat showed a phospholipase A1/2 (PLA1/2) activity toward phosphatidylcholine (PC). Phosphatidylcholines 144-163 lipase H Homo sapiens 120-124 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 21948389-1 2011 The kinetics of lecithin:cholesterol acyltransferase(LCAT, EC 2.3.1.43)-catalyzed generation of cholesteryl ester in discoidal high density lipoproteins (HDL) was analyzed in terms of initial binding of LCAT to the disc surface followed by a three-state reaction of the hydrolysis of phosphatidylcholine sn-2 ester bond and acyl-enzyme formation. Phosphatidylcholines 284-303 lecithin-cholesterol acyltransferase Homo sapiens 16-52 21948389-1 2011 The kinetics of lecithin:cholesterol acyltransferase(LCAT, EC 2.3.1.43)-catalyzed generation of cholesteryl ester in discoidal high density lipoproteins (HDL) was analyzed in terms of initial binding of LCAT to the disc surface followed by a three-state reaction of the hydrolysis of phosphatidylcholine sn-2 ester bond and acyl-enzyme formation. Phosphatidylcholines 284-303 lecithin-cholesterol acyltransferase Homo sapiens 53-57 21900497-9 2011 SAM is used as a methyl donor in three Opi1p-regulated reactions to create the abundant membrane phospholipid, phosphatidylcholine. Phosphatidylcholines 111-130 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 39-44 21937953-9 2011 Phosphatidylcholine pretreatment reduced the plasma TNF-alpha and hippocampal NOx changes and prevented the decreased neurogenesis. Phosphatidylcholines 0-19 tumor necrosis factor Rattus norvegicus 52-61 21937953-11 2011 Phosphatidylcholine supplementation did not reduce the overall extent of peripheral inflammatory activation, but efficiently counteracted the disturbed hippocampal neurogenesis by lowering circulating TNF-alpha concentrations. Phosphatidylcholines 0-19 tumor necrosis factor Rattus norvegicus 201-210 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 82-102 phospholipase A2 group IB Homo sapiens 168-186 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 82-102 phospholipase A2 group IB Homo sapiens 189-195 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 4-6 phospholipase A2 group IB Homo sapiens 168-186 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 4-6 phospholipase A2 group IB Homo sapiens 189-195 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 104-106 phospholipase A2 group IB Homo sapiens 168-186 21575006-2 2011 LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) ). Phosphatidylcholines 104-106 phospholipase A2 group IB Homo sapiens 189-195 21902184-3 2011 Recombinant TF was relipidated in liposomes of phosphatidylserine/phosphatidylcholine/biotin-linked phosphatidylethanolamine (20:79:1 PS/PC/bPE molar ratio). Phosphatidylcholines 66-85 coagulation factor III, tissue factor Homo sapiens 12-14 22102037-1 2011 Sec14 is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the yeast Saccharomyces cerevisiae and is the founding member of the Sec14 protein superfamily. Phosphatidylcholines 49-68 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 21837751-6 2011 In 3-KO mouse liver, there is a potent effect of MAT1A deletion on lipid handling, decreasing mobilization of TG stores, TG secretion in VLDL and phosphatidylcholine synthesis via phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 146-165 methionine adenosyltransferase I, alpha Mus musculus 49-54 21982710-0 2011 Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 97-136 21982710-5 2011 The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces. Phosphatidylcholines 24-26 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 185-224 21982710-5 2011 The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces. Phosphatidylcholines 24-26 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 226-229 22102037-1 2011 Sec14 is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the yeast Saccharomyces cerevisiae and is the founding member of the Sec14 protein superfamily. Phosphatidylcholines 49-68 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 167-172 21736954-0 2011 Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in axonal phosphatidylcholine synthesis and branching of neurons. Phosphatidylcholines 71-90 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 15-54 22076776-6 2011 Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor). Phosphatidylcholines 241-260 mitogen-activated protein kinase 3 Homo sapiens 13-20 22076776-6 2011 Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor). Phosphatidylcholines 241-260 mitogen-activated protein kinase 1 Homo sapiens 25-28 22076776-6 2011 Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor). Phosphatidylcholines 241-260 mitogen-activated protein kinase 3 Homo sapiens 29-33 21736954-0 2011 Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in axonal phosphatidylcholine synthesis and branching of neurons. Phosphatidylcholines 71-90 hemoglobin, beta adult minor chain Mus musculus 55-60 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 14-33 cut-like homeobox 1 Mus musculus 61-64 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 14-33 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 145-184 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 14-33 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 191-198 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 35-37 cut-like homeobox 1 Mus musculus 61-64 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 35-37 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 145-184 21736954-1 2011 In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2. Phosphatidylcholines 35-37 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 191-198 21682565-4 2011 METHODS: LOX1-targeted rho-kinase inhibitor fasudil-containing liposomes, composed of hydrogenated soy phosphatidylcholine/cholesterol/PEG(2000)-DSPE, were prepared by conjugating anti-LOX1 antibodies on the surface and by remote loading of fasudil. Phosphatidylcholines 103-122 oxidized low density lipoprotein receptor 1 Rattus norvegicus 9-13 21722629-5 2011 We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM. Phosphatidylcholines 145-164 interleukin 3 Mus musculus 82-95 21722629-5 2011 We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM. Phosphatidylcholines 145-164 interleukin 3 Mus musculus 97-101 21722629-5 2011 We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM. Phosphatidylcholines 166-168 interleukin 3 Mus musculus 82-95 21722629-5 2011 We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM. Phosphatidylcholines 166-168 interleukin 3 Mus musculus 97-101 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 14-36 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 38-42 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 1 Homo sapiens 44-58 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 102-144 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 146-151 21600318-1 2011 GuHCl-induced denaturation of human plasma apoA-I, apoA-II, apoA-IV, apoE3 and three recombinant apoE isoforms in solution and discoidal complexes with phosphatidylcholine (only plasma proteins) was studied. Phosphatidylcholines 152-171 apolipoprotein A1 Homo sapiens 43-49 21741352-1 2011 Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol. Phosphatidylcholines 119-138 protein kinase C alpha Homo sapiens 35-56 21741352-1 2011 Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol. Phosphatidylcholines 119-138 protein kinase C alpha Homo sapiens 58-66 21683785-2 2011 Anaphylatoxin C3a also binds and breaks bacterial lipid membranes and phosphatidylcholine liposomes. Phosphatidylcholines 70-89 complement C3 Homo sapiens 14-17 21649806-0 2011 Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1. Phosphatidylcholines 19-38 bile acid-transporting ATPase YBT1 Saccharomyces cerevisiae S288C 85-89 21649806-4 2011 Four ABC transporter proteins are found on the limiting membrane of the yeast vacuole and loss of one of these vacuolar ABC transporters, Ybt1, caused a major defect in the normal delivery of the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) to the lumen of the vacuole. Phosphatidylcholines 196-215 bile acid-transporting ATPase YBT1 Saccharomyces cerevisiae S288C 138-142 21649806-4 2011 Four ABC transporter proteins are found on the limiting membrane of the yeast vacuole and loss of one of these vacuolar ABC transporters, Ybt1, caused a major defect in the normal delivery of the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) to the lumen of the vacuole. Phosphatidylcholines 217-219 bile acid-transporting ATPase YBT1 Saccharomyces cerevisiae S288C 138-142 21820390-2 2011 ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts. Phosphatidylcholines 12-31 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-5 21820390-4 2011 Abcb4(-/-) mice lack biliary secretion of phosphatidylcholine, whereas Atp8b1-deficient mice have increased excretion of phosphatidylserine into bile. Phosphatidylcholines 42-61 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-5 21820390-11 2011 This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine. Phosphatidylcholines 162-181 ATPase, class I, type 8B, member 1 Mus musculus 71-77 21423211-2 2011 The product of choline kinase-alpha, phosphocholine, serves as an essential metabolic reservoir for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the production of lipid second messengers. Phosphatidylcholines 118-137 choline kinase alpha Homo sapiens 15-35 21688815-0 2011 Bovine insulin-phosphatidylcholine mixed Langmuir monolayers: behavior at the air-water interface. Phosphatidylcholines 15-34 insulin Bos taurus 7-14 21688815-4 2011 Our results indicate that intermolecular interactions between INS and PC depend on both the monolayer state and the structural characteristics of INS at the interface, which are strongly influenced by the subphase pH and salt content. Phosphatidylcholines 70-72 insulin Bos taurus 62-65 21688815-4 2011 Our results indicate that intermolecular interactions between INS and PC depend on both the monolayer state and the structural characteristics of INS at the interface, which are strongly influenced by the subphase pH and salt content. Phosphatidylcholines 70-72 insulin Bos taurus 146-149 21721951-7 2011 ADRP-LDs concomitantly stimulate saturated phosphatidylcholine (satPC) synthesis by A549 cells, which is inhibited by ADRP antibody, indicating that this is a receptor-mediated mechanism. Phosphatidylcholines 43-62 perilipin 2 Rattus norvegicus 0-4 21721951-7 2011 ADRP-LDs concomitantly stimulate saturated phosphatidylcholine (satPC) synthesis by A549 cells, which is inhibited by ADRP antibody, indicating that this is a receptor-mediated mechanism. Phosphatidylcholines 43-62 perilipin 2 Rattus norvegicus 118-122 21549185-2 2011 The primary structure of the peptide that we predicted coincided completely with the amino acid sequence of the later identified sphingomyelin synthase 1 protein (SMS1), which catalyses the transfer of a phosphorylcholine moiety from phosphatidylcholine to ceramide, producing sphingomyelin and diacylglycerol (Huitema et al., 2004; Yamaoka et al., 2004). Phosphatidylcholines 234-253 sphingomyelin synthase 1 Homo sapiens 129-161 21549185-2 2011 The primary structure of the peptide that we predicted coincided completely with the amino acid sequence of the later identified sphingomyelin synthase 1 protein (SMS1), which catalyses the transfer of a phosphorylcholine moiety from phosphatidylcholine to ceramide, producing sphingomyelin and diacylglycerol (Huitema et al., 2004; Yamaoka et al., 2004). Phosphatidylcholines 234-253 sphingomyelin synthase 1 Homo sapiens 163-167 21525137-0 2011 The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress. Phosphatidylcholines 4-23 phospholipase C1 Arabidopsis thaliana 36-51 21525137-0 2011 The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress. Phosphatidylcholines 4-23 non-specific phospholipase C4 Arabidopsis thaliana 52-56 21525137-1 2011 Phosphatidylcholine-hydrolysing phospholipase C, also known as non-specific phospholipase C (NPC), is a new member of the plant phospholipase family that reacts to environmental stresses such as phosphate deficiency and aluminium toxicity, and has a role in root development and brassinolide signalling. Phosphatidylcholines 0-19 phospholipase C1 Arabidopsis thaliana 32-47 21525137-1 2011 Phosphatidylcholine-hydrolysing phospholipase C, also known as non-specific phospholipase C (NPC), is a new member of the plant phospholipase family that reacts to environmental stresses such as phosphate deficiency and aluminium toxicity, and has a role in root development and brassinolide signalling. Phosphatidylcholines 0-19 phospholipase C1 Arabidopsis thaliana 76-91 21504799-1 2011 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis. Phosphatidylcholines 146-165 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 21504799-1 2011 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis. Phosphatidylcholines 146-165 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-55 21504799-1 2011 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis. Phosphatidylcholines 167-169 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 21504799-1 2011 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis. Phosphatidylcholines 167-169 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-55 21386858-7 2011 Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P<0.05) but negatively with leptin (r=-0.252, P<0.05), insulin (r=-0.335, P<0.01) and insulin resistance (r=-0.322, P<0.01). Phosphatidylcholines 19-38 adiponectin, C1Q and collagen domain containing Homo sapiens 87-98 21386858-7 2011 Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P<0.05) but negatively with leptin (r=-0.252, P<0.05), insulin (r=-0.335, P<0.01) and insulin resistance (r=-0.322, P<0.01). Phosphatidylcholines 19-38 leptin Homo sapiens 140-146 21386858-7 2011 Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P<0.05) but negatively with leptin (r=-0.252, P<0.05), insulin (r=-0.335, P<0.01) and insulin resistance (r=-0.322, P<0.01). Phosphatidylcholines 19-38 insulin Homo sapiens 170-177 21386858-7 2011 Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P<0.05) but negatively with leptin (r=-0.252, P<0.05), insulin (r=-0.335, P<0.01) and insulin resistance (r=-0.322, P<0.01). Phosphatidylcholines 19-38 insulin Homo sapiens 204-211 21511545-2 2011 Phospholipase A(2) (PLA(2)) quantitation in real-time, using (7-nitro-2-1,3-benzoxadiazol-4-yl)amino-derivatives of phosphatidylcholine (NBD-PCs) as substrates, is influenced by high protein content, color or turbidity. Phosphatidylcholines 116-135 phospholipase A2 group IB Homo sapiens 0-18 21413027-3 2011 Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs. Phosphatidylcholines 34-53 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 21511545-2 2011 Phospholipase A(2) (PLA(2)) quantitation in real-time, using (7-nitro-2-1,3-benzoxadiazol-4-yl)amino-derivatives of phosphatidylcholine (NBD-PCs) as substrates, is influenced by high protein content, color or turbidity. Phosphatidylcholines 116-135 phospholipase A2 group IB Homo sapiens 20-26 21454708-6 2011 Activity and protein of PE N-methyltransferase (PEMT), which produces PC by methylation of PE, are absent in 3T3-L1 fibroblasts but were induced at day 5. Phosphatidylcholines 70-72 phosphatidylethanolamine N-methyltransferase Mus musculus 24-46 21413027-3 2011 Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs. Phosphatidylcholines 34-53 C-C motif chemokine ligand 2 Homo sapiens 112-117 21312053-0 2011 Oxidized phosphatidylcholine induces migration of bone marrow-derived mesenchymal stem cells through Kruppel-like factor 4-dependent mechanism. Phosphatidylcholines 9-28 Kruppel like factor 4 Homo sapiens 101-122 21638239-1 2011 The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 4 Homo sapiens 25-29 21638239-1 2011 The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 4 Homo sapiens 44-49 21454645-1 2011 The exposure of the plasma membrane calcium pump (PMCA) to the surrounding phospholipids was assessed by measuring the incorporation of the photoactivatable phosphatidylcholine analog [(125)I]TID-PC/16 to the protein. Phosphatidylcholines 157-176 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 20-48 21454645-1 2011 The exposure of the plasma membrane calcium pump (PMCA) to the surrounding phospholipids was assessed by measuring the incorporation of the photoactivatable phosphatidylcholine analog [(125)I]TID-PC/16 to the protein. Phosphatidylcholines 157-176 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 50-54 21614002-3 2011 Here we show that an unusual phosphatidylcholine species with two saturated 12 carbon fatty acid acyl side chains (dilauroyl phosphatidylcholine (DLPC)) is an LRH-1 agonist ligand in vitro. Phosphatidylcholines 29-48 nuclear receptor subfamily 5, group A, member 2 Mus musculus 159-164 21614002-7 2011 These findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis. Phosphatidylcholines 43-62 nuclear receptor subfamily 5, group A, member 2 Mus musculus 27-32 21454708-6 2011 Activity and protein of PE N-methyltransferase (PEMT), which produces PC by methylation of PE, are absent in 3T3-L1 fibroblasts but were induced at day 5. Phosphatidylcholines 70-72 phosphatidylethanolamine N-methyltransferase Mus musculus 48-52 21411618-0 2011 Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. Phosphatidylcholines 31-50 phosphatidylethanolamine N-methyltransferase Homo sapiens 89-133 21521793-5 2011 We investigated possible participation of each of the three arms of the UPR and found that only the activating transcription factor 6 (ATF6) arm was selectively activated after induction of GFP-b(5)tail expression; peak ATF6alpha activation preceded the increase in phosphatidylcholine synthesis. Phosphatidylcholines 266-285 activating transcription factor 6 Homo sapiens 100-133 21521793-5 2011 We investigated possible participation of each of the three arms of the UPR and found that only the activating transcription factor 6 (ATF6) arm was selectively activated after induction of GFP-b(5)tail expression; peak ATF6alpha activation preceded the increase in phosphatidylcholine synthesis. Phosphatidylcholines 266-285 activating transcription factor 6 Homo sapiens 135-139 21411618-3 2011 Previously, we showed that mice that lack functional PEMT have dramatically reduced concentrations of docosahexaenoic acid (DHA; 22:6n-3) in plasma and of liver phosphatidylcholine (PtdCho)-a phospholipid formed by PEMT. Phosphatidylcholines 161-180 phosphatidylethanolamine N-methyltransferase Mus musculus 53-57 21411618-3 2011 Previously, we showed that mice that lack functional PEMT have dramatically reduced concentrations of docosahexaenoic acid (DHA; 22:6n-3) in plasma and of liver phosphatidylcholine (PtdCho)-a phospholipid formed by PEMT. Phosphatidylcholines 182-188 phosphatidylethanolamine N-methyltransferase Mus musculus 53-57 21411618-4 2011 OBJECTIVE: The objective was to evaluate plasma PtdCho-DHA concentrations as a noninvasive marker of liver PEMT activity in humans. Phosphatidylcholines 48-54 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-111 21290121-2 2011 Here the effect of the peptide hormone angiotensin II (Ang II), an agonist of the angiotensin receptors, on the structure of unilamellar and multilamellar dimyristoyl phosphatidylcholine vesicles was studied by small angle neutron scattering, dynamic light scattering and differential scanning calorimetry. Phosphatidylcholines 167-186 angiotensinogen Homo sapiens 39-53 21290121-2 2011 Here the effect of the peptide hormone angiotensin II (Ang II), an agonist of the angiotensin receptors, on the structure of unilamellar and multilamellar dimyristoyl phosphatidylcholine vesicles was studied by small angle neutron scattering, dynamic light scattering and differential scanning calorimetry. Phosphatidylcholines 167-186 angiotensinogen Homo sapiens 55-61 21389045-8 2011 Thus, both SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions. Phosphatidylcholines 83-85 putative S-adenosylmethionine synthase 1 Caenorhabditis elegans 11-17 21389045-8 2011 Thus, both SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions. Phosphatidylcholines 83-85 Phosphoethanolamine N-methyltransferase 1 Caenorhabditis elegans 22-27 21344950-3 2011 Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface. Phosphatidylcholines 49-51 prolactin induced protein Homo sapiens 20-23 21344950-3 2011 Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface. Phosphatidylcholines 49-51 secretoglobin family 2B member 3, pseudogene Homo sapiens 152-155 21344950-3 2011 Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface. Phosphatidylcholines 49-51 secretoglobin family 2B member 3, pseudogene Homo sapiens 193-196 21085975-3 2011 Complex of curcumin with phosphatidyl choline (PC) was prepared and characterized on the basis of TLC, DSC, melting point and IR spectroscopic analysis. Phosphatidylcholines 25-45 declival sulcus of cerebellum Mus musculus 103-106 21118090-5 2011 MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space. Phosphatidylcholines 31-50 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 0-4 21118090-5 2011 MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space. Phosphatidylcholines 31-50 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 5-9 21118090-5 2011 MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space. Phosphatidylcholines 31-50 ATP binding cassette subfamily G member 5 Mus musculus 14-19 21118090-5 2011 MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space. Phosphatidylcholines 31-50 ATP-binding cassette, sub-family B (MDR/TAP), member 11 Mus musculus 103-107 21273556-0 2011 Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice. Phosphatidylcholines 9-28 apolipoprotein E Mus musculus 112-116 21085975-3 2011 Complex of curcumin with phosphatidyl choline (PC) was prepared and characterized on the basis of TLC, DSC, melting point and IR spectroscopic analysis. Phosphatidylcholines 47-49 declival sulcus of cerebellum Mus musculus 103-106 20937607-2 2011 The signaling of these receptors change phosphatidylcholine-specific phospholipase C (PC-PLC) activity, but there have been no reported PC-PLC studies in migraine. Phosphatidylcholines 40-59 heparan sulfate proteoglycan 2 Homo sapiens 89-92 21291330-1 2011 BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids. Phosphatidylcholines 119-139 phospholipase A2 group VII Homo sapiens 12-51 21291330-1 2011 BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids. Phosphatidylcholines 119-139 phospholipase A2 group VII Homo sapiens 53-60 21080035-6 2011 Binding of prothrombin to a surface containing 20% phosphatidylserine/80% phosphatidylcholine was detected by surface plasmon resonance, whereas no interaction with gla-domainless prothrombin was observed. Phosphatidylcholines 74-93 coagulation factor II, thrombin Homo sapiens 11-22 21149645-4 2011 Phosphatidylcholines (PCs) composing saturated and monounsaturated fatty acids (PC 32:0, PC 32:1, and PC 34:1) were detected mainly in the outer and inner plexiform layers (OPL and IPL), whereas PCs containing polyunsaturated fatty acids (PC 36:4, PC 38:6, and PC 40:6) composed the inner segment (IS) and outer segment (OS). Phosphatidylcholines 0-20 pleckstrin homology like domain family A member 2 Homo sapiens 181-184 21149645-4 2011 Phosphatidylcholines (PCs) composing saturated and monounsaturated fatty acids (PC 32:0, PC 32:1, and PC 34:1) were detected mainly in the outer and inner plexiform layers (OPL and IPL), whereas PCs containing polyunsaturated fatty acids (PC 36:4, PC 38:6, and PC 40:6) composed the inner segment (IS) and outer segment (OS). Phosphatidylcholines 22-25 pleckstrin homology like domain family A member 2 Homo sapiens 181-184 21149645-5 2011 The presence of PCs containing polyunsaturated fatty acids in the OS layer implied that these phospholipids form flexible lipid bilayers, which facilitate phototransduction process occurring in the rhodopsin rich OS layer. Phosphatidylcholines 16-19 rhodopsin Homo sapiens 198-207 21270363-5 2011 More than one-half of premenopausal women may be resistant to choline deficiency-induced organ dysfunction, because estrogen induces the gene [phosphatidylethanolamine-N-methyltransferase (PEMT)] that catalyzes endogenous synthesis of phosphatidylcholine, which can subsequently yield choline. Phosphatidylcholines 235-254 phosphatidylethanolamine N-methyltransferase Homo sapiens 143-187 21270363-5 2011 More than one-half of premenopausal women may be resistant to choline deficiency-induced organ dysfunction, because estrogen induces the gene [phosphatidylethanolamine-N-methyltransferase (PEMT)] that catalyzes endogenous synthesis of phosphatidylcholine, which can subsequently yield choline. Phosphatidylcholines 235-254 phosphatidylethanolamine N-methyltransferase Homo sapiens 189-193 21266973-12 2011 CONCLUSIONS: The transition to tumourigenesis in prostate epithelial cell lines results in major changes to Cho metabolite release into the medium and PKC signalling to phosphatidylcholine turnover. Phosphatidylcholines 169-188 protein kinase C alpha Homo sapiens 151-154 21177434-2 2011 Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils. Phosphatidylcholines 156-175 arachidonate 5-lipoxygenase Homo sapiens 13-18 21210202-0 2011 Phosphatidylcholine-rich nanoliposomes: potential tools for serum C-reactive protein reduction? Phosphatidylcholines 0-19 C-reactive protein Homo sapiens 66-84 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 203-205 cut-like homeobox 1 Rattus norvegicus 79-82 21315271-2 2011 [(18)F]FECH is actively transported into mammalian cells, becomes phosphorylated by choline kinase and gets incorporated into the cell membrane after being metabolized to phosphatidylcholine. Phosphatidylcholines 171-190 ferrochelatase Homo sapiens 7-11 21415529-3 2011 When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL>PS>PE>PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids. Phosphatidylcholines 57-76 microsomal glutathione S-transferase 1 Homo sapiens 5-10 21173026-7 2011 Analysis of HFA-triacylglycerol molecular species and regiochemistry, along with analysis of the HFA content of phosphatidylcholine, indicates that RcPDAT1A functions as a PDAT in vivo. Phosphatidylcholines 112-131 phospholipid:diacylglycerol acyltransferase Arabidopsis thaliana 150-154 20601268-2 2011 After a 24-hour reaction of phosphatidylcholine (PC) and tyrosol with PLD, a new product was detected by TLC and identified to phosphatidyl-tyrosol by high-resolution MS and NMR analyses. Phosphatidylcholines 28-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 21415529-3 2011 When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL>PS>PE>PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids. Phosphatidylcholines 78-80 microsomal glutathione S-transferase 1 Homo sapiens 5-10 21415529-3 2011 When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL>PS>PE>PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids. Phosphatidylcholines 103-105 microsomal glutathione S-transferase 1 Homo sapiens 5-10 21738695-0 2011 Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of betaI-spectrin. Phosphatidylcholines 70-89 spectrin beta, erythrocytic Homo sapiens 112-126 22022488-6 2011 The affinity of PDC-109 for phosphatidylcholine increased at higher pH, which is physiologically relevant in view of the basic nature of the seminal plasma. Phosphatidylcholines 28-47 seminal plasma protein PDC-109 Bos taurus 16-23 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 79-82 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 245-289 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 291-295 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 21-23 cut-like homeobox 1 Rattus norvegicus 79-82 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 245-289 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 291-295 21074554-1 2011 A phospholipase A2 was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. Phosphatidylcholines 122-141 phospholipase A2 group IB Canis lupus familiaris 2-18 21094990-3 2011 PLA(2) activity in TEU-2 cells was measured using (16:0, [(3)H]18:1) plasmenylcholine and phosphatidylcholine substrates in the presence and absence of calcium. Phosphatidylcholines 90-109 phospholipase A2 group IB Homo sapiens 0-6 20974857-4 2010 Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 125-144 phospholipase A2 group X Homo sapiens 10-19 21126034-1 2010 Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively). Phosphatidylcholines 233-252 lysozyme Homo sapiens 173-181 21126034-1 2010 Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively). Phosphatidylcholines 233-252 lysozyme Homo sapiens 183-185 21126034-1 2010 Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively). Phosphatidylcholines 254-256 lysozyme Homo sapiens 173-181 21126034-1 2010 Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively). Phosphatidylcholines 254-256 lysozyme Homo sapiens 183-185 21126034-2 2010 Upon binding to PC, PG5, or PG10 model membranes, Lz was found to retain its native monomeric conformation, while increasing content of anionic lipid up to 20 or 40 mol % resulted in the formation of Lz aggregates. Phosphatidylcholines 16-18 lysozyme Homo sapiens 50-52 21156133-4 2010 We used optical tweezers to measure the strength and attachment lifetime of single myo1c molecules as they bind beads coated with a bilayer of 2% phosphatidylinositol 4,5-bisphosphate and 98% phosphatidylcholine. Phosphatidylcholines 192-211 myosin IC Homo sapiens 83-88 24061892-1 2010 Secreted group X phospholipase A2 (sPLA2-X) is one of the most effective mammalian PLA2 enzymes at hydrolyzing plasma lipoproteins and phospholipids in the membranes of intact cells, due in particular to its relatively high binding affinity to zwitterionic phospholipid substrates, such as phosphatidylcholine. Phosphatidylcholines 290-309 phospholipase A2 group X Homo sapiens 35-42 24061892-1 2010 Secreted group X phospholipase A2 (sPLA2-X) is one of the most effective mammalian PLA2 enzymes at hydrolyzing plasma lipoproteins and phospholipids in the membranes of intact cells, due in particular to its relatively high binding affinity to zwitterionic phospholipid substrates, such as phosphatidylcholine. Phosphatidylcholines 290-309 phospholipase A2 group IIA Homo sapiens 36-40 20732453-10 2010 This data indicated that during the interaction between human HDL and phosphatidylcholine liposome apo A-II participates both in structural modification of liposomes and in the generation of pre-beta mobility fraction of constant content of PL, apo A-I and apo A-II. Phosphatidylcholines 70-89 apolipoprotein A2 Homo sapiens 99-107 20732453-10 2010 This data indicated that during the interaction between human HDL and phosphatidylcholine liposome apo A-II participates both in structural modification of liposomes and in the generation of pre-beta mobility fraction of constant content of PL, apo A-I and apo A-II. Phosphatidylcholines 70-89 apolipoprotein A1 Homo sapiens 245-265 20858845-1 2010 In a previous report, we identified the receptor for activated C-kinase 1 (RACK1) as a positive regulator of the cellular localization and expression of ATP-binding cassette B4, a phosphatidylcholine translocator expressed on the bile canalicular membrane. Phosphatidylcholines 180-199 receptor for activated C kinase 1 Homo sapiens 40-73 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 101-105 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-129 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 75-77 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 101-105 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-129 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20858845-1 2010 In a previous report, we identified the receptor for activated C-kinase 1 (RACK1) as a positive regulator of the cellular localization and expression of ATP-binding cassette B4, a phosphatidylcholine translocator expressed on the bile canalicular membrane. Phosphatidylcholines 180-199 receptor for activated C kinase 1 Homo sapiens 75-80 21117173-2 2010 Additionally, the effect of cholesterol on the binding of PDC-109 to phosphatidylcholine (PC) membranes was studied. Phosphatidylcholines 69-88 seminal plasma protein PDC-109 Bos taurus 58-65 20861172-2 2010 Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Homo sapiens 47-91 20861172-2 2010 Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Homo sapiens 93-97 21117173-5 2010 AFM results are consistent with the above findings and show that addition of PDC-109 leads to a complete breakdown of PC membranes. Phosphatidylcholines 118-120 seminal plasma protein PDC-109 Bos taurus 77-84 21117173-2 2010 Additionally, the effect of cholesterol on the binding of PDC-109 to phosphatidylcholine (PC) membranes was studied. Phosphatidylcholines 90-92 seminal plasma protein PDC-109 Bos taurus 58-65 20853818-6 2010 The donor chain length limit of C10 coincides with the phosphatidylcholine transition from displaying bilayer to micellar properties in water, but the detergent inhibitor lauryldimethylamine N-oxide also gradually became ineffective in a micellar assay as the selected acyl chains were shortened to C10. Phosphatidylcholines 55-74 chromosome 12 open reading frame 57 Homo sapiens 32-35 20925360-5 2010 Possible lipid binding sites on the surface of Osh4 were identified by docking four lipid moieties modeled from different lipid head groups (phosphatidylcholine, phosphatidylserine, phosphatidylinositol(4,5)biphosphate, and phosphatidylinositol(3,4,5)triphosphate). Phosphatidylcholines 141-160 oxysterol-binding protein KES1 Saccharomyces cerevisiae S288C 47-51 20642808-3 2010 Cytosolic phospholipase A2 (cPLA(2) ) is an enzyme that is responsible for the hydrolysis of membrane phospholipids such as phosphatidylcholine. Phosphatidylcholines 124-143 phospholipase A2 group IVA Homo sapiens 0-35 20620034-1 2010 Total internal reflection fluorescence microscopy (TIRFM) has been utilized to explore the effect of cationic protein lysozyme (Lz) on the morphology of solid-supported lipid bilayers (SLBs) comprised of zwitterionic lipid phosphatidylcholine (PC) and its mixture with anionic lipid cardiolipin (CL). Phosphatidylcholines 223-242 lysozyme Homo sapiens 128-130 20620034-1 2010 Total internal reflection fluorescence microscopy (TIRFM) has been utilized to explore the effect of cationic protein lysozyme (Lz) on the morphology of solid-supported lipid bilayers (SLBs) comprised of zwitterionic lipid phosphatidylcholine (PC) and its mixture with anionic lipid cardiolipin (CL). Phosphatidylcholines 244-246 lysozyme Homo sapiens 128-130 20642808-4 2010 Following activation, cPLA(2) cleaves phosphatidylcholine to yield free fatty acid and lysophosphatidylcholine. Phosphatidylcholines 38-57 phospholipase A2 group IVA Homo sapiens 22-29 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20628054-2 2010 Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 164-183 lecithin retinol acyltransferase Homo sapiens 0-32 20858419-1 2010 Resonance energy transfer (RET) from anthrylvinyl-labeled phosphatidylcholine (AV-PC) or cardiolipin (AV-CL) to cytochrome c (cyt c) heme moiety was employed to assess the molecular-level details of protein interactions with lipid bilayers composed of PC with 2.5 (CL2.5), 5 (CL5), 10 (CL10), or 20 (CL20) mol % CL under conditions of varying ionic strength and lipid/protein molar ratio. Phosphatidylcholines 58-77 cytochrome c, somatic Homo sapiens 112-124 20858419-1 2010 Resonance energy transfer (RET) from anthrylvinyl-labeled phosphatidylcholine (AV-PC) or cardiolipin (AV-CL) to cytochrome c (cyt c) heme moiety was employed to assess the molecular-level details of protein interactions with lipid bilayers composed of PC with 2.5 (CL2.5), 5 (CL5), 10 (CL10), or 20 (CL20) mol % CL under conditions of varying ionic strength and lipid/protein molar ratio. Phosphatidylcholines 58-77 cytochrome c, somatic Homo sapiens 126-131 20628054-2 2010 Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 164-183 lecithin retinol acyltransferase Homo sapiens 34-38 20628054-4 2010 Detailed mass spectrometry analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine substrates. Phosphatidylcholines 134-153 lecithin retinol acyltransferase Homo sapiens 50-54 20628054-7 2010 Additionally, we examined the effect of increasing fatty acyl side chain length in phosphatidylcholine on substrate accessibility in this reaction, which provided insights into the function of the single membrane-spanning domain of LRAT. Phosphatidylcholines 83-102 lecithin retinol acyltransferase Homo sapiens 232-236 20570648-5 2010 Here we investigate the structure and aggregation properties of hIAPP(1-19) in relation to membrane damage in vitro by using membranes of the zwitterionic lipid phosphatidylcholine (PC), the anionic lipid phosphatidylserine (PS) and mixtures of these lipids to mimic membranes of islet cells. Phosphatidylcholines 161-180 islet amyloid polypeptide Homo sapiens 64-69 20452975-2 2010 Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 32-34 phosphatidylethanolamine N-methyltransferase Mus musculus 108-152 20380879-1 2010 As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 92-111 patatin like phospholipase domain containing 6 Homo sapiens 22-48 20380879-1 2010 As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 92-111 patatin like phospholipase domain containing 6 Homo sapiens 50-53 20380879-1 2010 As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 113-115 patatin like phospholipase domain containing 6 Homo sapiens 22-48 20380879-1 2010 As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 113-115 patatin like phospholipase domain containing 6 Homo sapiens 50-53 20525991-3 2010 We demonstrate that during retinoic acid (RA)-induced differentiation of Neuro-2a cells, PtdCho synthesis was promoted by an ordered and sequential activation of choline kinase alpha (CK(alpha)) and choline cytidylyltransferase alpha (CCT(alpha)). Phosphatidylcholines 89-95 choline kinase alpha Mus musculus 162-193 20525991-3 2010 We demonstrate that during retinoic acid (RA)-induced differentiation of Neuro-2a cells, PtdCho synthesis was promoted by an ordered and sequential activation of choline kinase alpha (CK(alpha)) and choline cytidylyltransferase alpha (CCT(alpha)). Phosphatidylcholines 89-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 235-245 20699392-6 2010 PEAMT catalyzes the first committed step of choline synthesis in Arabidopsis and defines a variant pathway for PC synthesis not found in yeasts or mammals. Phosphatidylcholines 111-113 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 0-5 20579106-2 2010 PLD1 preferentially hydrolyzes phosphatidylcholine to phosphatidic acid. Phosphatidylcholines 31-50 phospholipase D Saccharomyces cerevisiae S288C 0-4 20674552-3 2010 The present work demonstrates that the interactions between the protein BSP1 and model membranes composed with phosphatidylcholine lead to drastic changes in the morphology of the lipidic self-assemblies. Phosphatidylcholines 111-130 seminal plasma protein PDC-109 Bos taurus 72-76 20651827-4 2010 Sec14 was first identified as a phosphatidylcholine (PC) - phosphatidylinositol (PI) transfer protein required for viability, with reduced Sec14 function resulting in diminished vesicular transport out of the trans-Golgi. Phosphatidylcholines 32-51 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 20651827-4 2010 Sec14 was first identified as a phosphatidylcholine (PC) - phosphatidylinositol (PI) transfer protein required for viability, with reduced Sec14 function resulting in diminished vesicular transport out of the trans-Golgi. Phosphatidylcholines 53-55 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 20891039-3 2010 In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to. Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 17-20 20891039-3 2010 In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to. Phosphatidylcholines 133-152 phospholipase A and acyltransferase 1 Homo sapiens 47-62 20891039-3 2010 In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to. Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 235-238 20891039-6 2010 For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane. Phosphatidylcholines 61-80 phospholipase A and acyltransferase 1 Homo sapiens 33-48 20891039-6 2010 For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane. Phosphatidylcholines 61-80 C-reactive protein Homo sapiens 125-128 20891039-6 2010 For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane. Phosphatidylcholines 61-80 C-reactive protein Homo sapiens 236-239 20153493-2 2010 In humans, ABCB4 appears to be exclusively expressed on the apical membrane of hepatocytes where it translocates phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 113-132 ATP binding cassette subfamily B member 4 Homo sapiens 11-16 20489212-6 2010 Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells. Phosphatidylcholines 4-23 lysophosphatidylcholine acyltransferase 3 Homo sapiens 43-49 20489212-6 2010 Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells. Phosphatidylcholines 4-23 stearoyl-CoA desaturase Homo sapiens 160-164 20452975-2 2010 Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 32-34 phosphatidylethanolamine N-methyltransferase Mus musculus 154-158 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20598156-1 2010 BACKGROUND: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. Phosphatidylcholines 33-52 ATP binding cassette subfamily B member 4 Canis lupus familiaris 12-17 20598156-1 2010 BACKGROUND: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Canis lupus familiaris 12-17 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 27713341-1 2010 Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine. Phosphatidylcholines 74-93 phospholipase D2 Mus musculus 0-16 27713341-1 2010 Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine. Phosphatidylcholines 74-93 phospholipase D2 Mus musculus 18-22 19684306-1 2010 CTP:phosphocholine cytidylyltransferase (CCTalpha) plays a key role in the biosynthesis of surfactant phosphatidylcholine. Phosphatidylcholines 102-121 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 19684306-1 2010 CTP:phosphocholine cytidylyltransferase (CCTalpha) plays a key role in the biosynthesis of surfactant phosphatidylcholine. Phosphatidylcholines 102-121 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-49 19684306-11 2010 Only overexpression of CCTalpha(1-367) increased surfactant phosphatidylcholine synthesis. Phosphatidylcholines 60-79 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 23-31 20346413-0 2010 Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Phosphatidylcholines 101-120 plasminogen Homo sapiens 26-37 20346413-0 2010 Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Phosphatidylcholines 101-120 lipoprotein(a) Homo sapiens 64-81 20346413-1 2010 Human apolipoprotein(a) (apo(a)), synthesized in the liver, contains oxidized phosphatidylcholine (oxPtdPC) adducts probably generated at the hepatic site. Phosphatidylcholines 78-97 lipoprotein(a) Homo sapiens 6-23 20338778-1 2010 Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. Phosphatidylcholines 67-87 phosphatidylcholine transfer protein Mus musculus 0-36 20519644-4 2010 We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro. Phosphatidylcholines 179-198 CD1b molecule Bos taurus 73-77 20519644-4 2010 We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro. Phosphatidylcholines 179-198 CD1b molecule Bos taurus 88-93 20338778-1 2010 Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. Phosphatidylcholines 67-87 phosphatidylcholine transfer protein Mus musculus 38-43 20338778-1 2010 Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. Phosphatidylcholines 67-87 phosphatidylcholine transfer protein Mus musculus 53-59 20338778-6 2010 Because PC-TP discriminates between phosphatidylcholines within lipid bilayers, it might function as a sensor that links metabolic regulation to membrane composition. Phosphatidylcholines 36-56 phosphatidylcholine transfer protein Mus musculus 8-13 20144678-7 2010 Much higher concentrations of sPLA(2)-IIA are required for its action on host cell membranes and surfactant both of which are mainly composed by phosphatidylcholine, a poor substrate for sPLA(2)-IIA. Phosphatidylcholines 145-164 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 30-41 20153800-8 2010 Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis. Phosphatidylcholines 96-115 phospholipase A2 group IIA Homo sapiens 15-20 20153800-8 2010 Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis. Phosphatidylcholines 96-115 phospholipase A2 group IIA Homo sapiens 22-27 20452604-4 2010 We selected the specific detection approach by neutral loss survey-dependent MS3, for the identification of molecular species of phosphatidylcholine, sphingomyelin and phosphatidylserine. Phosphatidylcholines 129-148 minisatellites detected by probe MMS3 Mus musculus 77-80 20345604-8 2010 Detailed analyses of acyl lipid composition indicated that all suppressors alleviated the increase in the level of linoleic acid esterified to phosphatidylcholine (PC-18:2) in LT-treated vte2, and this alleviation significantly correlated with their extent of suppression of photoassimilate export. Phosphatidylcholines 143-162 homogentisate phytyltransferase 1 Arabidopsis thaliana 187-191 20153800-8 2010 Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis. Phosphatidylcholines 96-115 phospholipase A2 group IIA Homo sapiens 42-47 20185359-6 2010 However, it is equally clear that a holistic understanding of plant lipid metabolism is still lacking, mainly owing to the continually emerging complexity and interplay between pathways, recently exemplified by the identification of the ROD1 phosphatidylcholine:diacylglycerol cholinephosphotransferase involved in the channelling of unsaturated fatty acids into storage oil. Phosphatidylcholines 242-261 polypyrimidine tract binding protein 3 Homo sapiens 237-241 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. Phosphatidylcholines 26-28 cut like homeobox 1 Homo sapiens 144-147 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. Phosphatidylcholines 26-28 cut like homeobox 1 Homo sapiens 159-162 19937605-9 2010 This difference was attributed to the tenfold reduction in phosphatidylcholine concentration in the infant model limiting the protective effect of this phospholipid on beta-Lg digestion. Phosphatidylcholines 59-78 beta-lactoglobulin Bos taurus 168-175 20345632-6 2010 *On lipid and acyl-CoA analyses, the siliques, but not the leaves, of the acbp1 mutant accumulated galactolipid monogalactosyldiacylglycerol and 18:0-CoA, but the levels of most polyunsaturated species of phospholipid, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine, declined. Phosphatidylcholines 227-246 acyl-CoA binding protein 1 Arabidopsis thaliana 74-79 20507939-0 2010 Plant phosphatidylcholine-hydrolyzing phospholipases C NPC3 and NPC4 with roles in root development and brassinolide signaling in Arabidopsis thaliana. Phosphatidylcholines 6-25 non-specific phospholipase C3 Arabidopsis thaliana 55-59 19940811-3 2010 We proposed that sPLA2 acted on the gastric hydrophobic barrier, composed primarily of phosphatidylcholine (PC), to degrade it and produce lyso-PC, an agent that is damaging to the mucosa. Phosphatidylcholines 87-106 phospholipase A2 group IIA Rattus norvegicus 17-22 19940811-3 2010 We proposed that sPLA2 acted on the gastric hydrophobic barrier, composed primarily of phosphatidylcholine (PC), to degrade it and produce lyso-PC, an agent that is damaging to the mucosa. Phosphatidylcholines 108-110 phospholipase A2 group IIA Rattus norvegicus 17-22 20332534-8 2010 Moreover, deletion of TGL4 in Saccharomyces cerevisiae showed an altered pattern of phosphatidylcholine and PA molecular species. Phosphatidylcholines 84-103 triacylglycerol lipase Saccharomyces cerevisiae S288C 22-26 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 20424323-5 2010 During epididymal transit, phosphatidylcholine in the membrane of Pla2g3+/+ sperm underwent a dramatic shift in its acyl groups from oleic, linoleic, and arachidonic acids to docosapentaenoic and docosahexaenoic acids, whereas this membrane lipid remodeling event was compromised in sperm from Pla2g3-/- mice. Phosphatidylcholines 27-46 phospholipase A2, group III Mus musculus 66-72 20424323-5 2010 During epididymal transit, phosphatidylcholine in the membrane of Pla2g3+/+ sperm underwent a dramatic shift in its acyl groups from oleic, linoleic, and arachidonic acids to docosapentaenoic and docosahexaenoic acids, whereas this membrane lipid remodeling event was compromised in sperm from Pla2g3-/- mice. Phosphatidylcholines 27-46 phospholipase A2, group III Mus musculus 294-300 20053799-9 2010 We find that AtPLAIVA and AtPLAIVB are phosphorylated by calcium-dependent protein kinases in vitro and this enhances their activities on phosphatidylcholine but not on phosphatidylglycerol. Phosphatidylcholines 138-157 PATATIN-like protein 5 Arabidopsis thaliana 26-34 20507939-0 2010 Plant phosphatidylcholine-hydrolyzing phospholipases C NPC3 and NPC4 with roles in root development and brassinolide signaling in Arabidopsis thaliana. Phosphatidylcholines 6-25 non-specific phospholipase C4 Arabidopsis thaliana 64-68 20442372-8 2010 Observations that recombinant ACBP3 binds PC, PE, and unsaturated acyl-CoAs in vitro and that ACBP3 overexpression enhances degradation of the autophagy (ATG)-related protein ATG8 and disrupts autophagosome formation suggest a role for ACBP3 as a phospholipid binding protein involved in the regulation of leaf senescence by modulating membrane phospholipid metabolism and ATG8 stability in Arabidopsis. Phosphatidylcholines 42-44 acyl-CoA-binding domain 3 Arabidopsis thaliana 30-35 20332109-0 2010 Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. Phosphatidylcholines 26-45 phosphatidylinositol transfer protein beta Homo sapiens 67-75 20422496-1 2010 Class III multidrug resistance P-glycoproteins, Mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. Phosphatidylcholines 157-176 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 48-52 20422496-1 2010 Class III multidrug resistance P-glycoproteins, Mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. Phosphatidylcholines 157-176 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 65-69 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 112-116 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 11 Homo sapiens 121-125 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 215-219 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 222-227 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 11 Homo sapiens 233-237 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 11 Homo sapiens 240-246 20364851-0 2010 C-reactive protein induced rearrangement of phosphatidylcholine on nanoparticle mimics of lipoprotein particles. Phosphatidylcholines 44-63 C-reactive protein Homo sapiens 0-18 20150657-2 2010 Another major pathway for phosphatidylcholine biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 26-45 phosphatidylethanolamine N-methyltransferase Mus musculus 84-128 20150657-2 2010 Another major pathway for phosphatidylcholine biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 26-45 phosphatidylethanolamine N-methyltransferase Mus musculus 130-134 20332109-2 2010 Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear. Phosphatidylcholines 125-144 phosphatidylinositol transfer protein beta Homo sapiens 0-42 20332109-2 2010 Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear. Phosphatidylcholines 125-144 phosphatidylinositol transfer protein beta Homo sapiens 44-52 20332109-2 2010 Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear. Phosphatidylcholines 146-152 phosphatidylinositol transfer protein beta Homo sapiens 0-42 20332109-2 2010 Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear. Phosphatidylcholines 146-152 phosphatidylinositol transfer protein beta Homo sapiens 44-52 20096375-1 2010 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a key enzyme for phosphatidylcholine biosynthesis in mammalian cells. Phosphatidylcholines 77-96 phosphate cytidylyltransferase 1A, choline Homo sapiens 0-45 20026284-6 2010 Although choline kinase activity is decreased in forelimb muscles of Chkb(-/-) mice, the activity of CTP:phosphocholine cytidylyltransferase is increased, resulting in enhanced phosphatidylcholine biosynthesis. Phosphatidylcholines 177-196 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 101-140 20210361-3 2010 In this study, turbidity measurements were conducted to provide a detailed description of the binding reaction between IAPP fibrils and lipid vesicles made from phosphatidylcholine. Phosphatidylcholines 161-180 islet amyloid polypeptide Homo sapiens 119-123 19892352-2 2010 Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT). Phosphatidylcholines 0-19 lecithin-cholesterol acyltransferase Homo sapiens 194-230 19892352-2 2010 Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT). Phosphatidylcholines 0-19 lecithin-cholesterol acyltransferase Homo sapiens 232-236 19892352-2 2010 Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT). Phosphatidylcholines 21-23 lecithin-cholesterol acyltransferase Homo sapiens 194-230 19892352-2 2010 Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT). Phosphatidylcholines 21-23 lecithin-cholesterol acyltransferase Homo sapiens 232-236 20045741-2 2010 The rate-limiting step for phosphatidylcholine biosynthesis by the CDP-choline pathway is also the second step, which is catalyzed by CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 27-46 cut-like homeobox 1 Mus musculus 67-70 20045741-2 2010 The rate-limiting step for phosphatidylcholine biosynthesis by the CDP-choline pathway is also the second step, which is catalyzed by CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 27-46 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 134-173 20096375-1 2010 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a key enzyme for phosphatidylcholine biosynthesis in mammalian cells. Phosphatidylcholines 77-96 phosphate cytidylyltransferase 1A, choline Homo sapiens 47-55 20096375-8 2010 In conclusion, the present results allowed us to portray the clearest picture of the CCTalpha-gene expression in proliferating cells, and understand the mechanism by which cells coordinate cell cycle progression with the requirement for phosphatidylcholine. Phosphatidylcholines 237-256 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 85-93 19778326-14 2010 CONCLUSION: This is the first report to show the presence of apolipoprotein B and apolipoprotein B- oxidized phosphatidylcholine complex, which correspond to LDL and OxLDL, respectively, in gingival crevicular fluid. Phosphatidylcholines 109-128 apolipoprotein B Homo sapiens 82-98 20392582-4 2010 The group provides now a solid evidence that endogenous lipid synthesis generates a discrete phosphatidylcholine species, 1-palmitoyl 2-oleyl phosphatidylcholine (16:0/18:1 PC), that serves as an endogenous ligand for PPARalpha. Phosphatidylcholines 93-112 peroxisome proliferator activated receptor alpha Homo sapiens 218-227 20193962-6 2010 The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes. Phosphatidylcholines 112-114 BCL2 apoptosis regulator Homo sapiens 47-52 20193962-6 2010 The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes. Phosphatidylcholines 112-114 BCL2 like 1 Homo sapiens 57-63 20193962-6 2010 The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes. Phosphatidylcholines 112-114 transmembrane BAX inhibitor motif containing 6 Homo sapiens 88-92 20007511-2 2010 Phosphatidylcholine, an indispensible membrane component, requires the enzyme CCTalpha for its biosynthesis. Phosphatidylcholines 0-19 t-complex 1 Homo sapiens 78-86 20007511-8 2010 14-3-3zeta was critically involved in preserving phosphatidylcholine synthesis and cell viability in a model of Pseudomonas aeruginosa infection where Ca(2+) concentrations increase within epithelia. Phosphatidylcholines 49-68 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 0-10 20018880-2 2010 Overexpression of the remodeling enzyme, LPCAT1 (acyl-CoA:lysophosphatidylcholine acyltransferase) in epithelia decreased de novo PtdCho synthesis without significantly altering cellular PtdCho mass. Phosphatidylcholines 130-136 lysophosphatidylcholine acyltransferase 1 Homo sapiens 41-47 19878733-7 2010 On day 7 mRNA expression of inducible NO synthase and nitrite/nitrate levels in BALF were higher in VENT than in ECMO, interleukin-8 mRNA expression and lung apoptosis were lower in ENOS than in ECMO; disaturated phosphatidylcholine and mRNA expression of hepatocyte growth factor were higher, interleukin-8 content, NO synthase mRNA expression and malondialdehyde in lung tissue were lower, and morphologically lung injury and apoptosis were milder, in ENOS than in VENT. Phosphatidylcholines 213-232 nitric oxide synthase 2 Homo sapiens 28-49 20338039-5 2010 Likewise, treatment with miltefosine produces an interference with the biosynthesis of phosphatidylcholine via both CDP-choline and phosphatidylethanolamine methylation. Phosphatidylcholines 87-106 cut like homeobox 1 Homo sapiens 116-119 20166680-6 2010 Incorporation of linoleic acid into phosphatidylcholine-containing model vesicles enabled them to interact with the C1q globular domain and to trigger C1 activation, and cholesterol enhanced both processes by facilitating incorporation of the fatty acid into the vesicles. Phosphatidylcholines 36-55 complement C1q A chain Homo sapiens 116-119 20107029-4 2010 ACBP1 overexpressors showed reduction in several species of diunsaturated phosphatidylcholine (PC), prompting us to investigate if they were altered in response to freezing stress. Phosphatidylcholines 95-97 acyl-CoA binding protein 1 Arabidopsis thaliana 0-5 20107029-5 2010 ACBP1 overexpressors demonstrated increased freezing sensitivity accompanied by a decrease in PC and an increase in phosphatidic acid (PA), while acbp1 mutant plants showed enhanced freezing tolerance associated with PC accumulation and PA reduction. Phosphatidylcholines 94-96 acyl-CoA binding protein 1 Arabidopsis thaliana 0-5 20107029-5 2010 ACBP1 overexpressors demonstrated increased freezing sensitivity accompanied by a decrease in PC and an increase in phosphatidic acid (PA), while acbp1 mutant plants showed enhanced freezing tolerance associated with PC accumulation and PA reduction. Phosphatidylcholines 217-219 acyl-CoA binding protein 1 Arabidopsis thaliana 146-151 20107029-7 2010 Since phospholipase Dalpha1 (PLDalpha1) is a major enzyme promoting the hydrolysis of PC to PA, PLDalpha1 expression was examined and was observed to be higher in ACBP1 overexpressors than in acbp1 mutant plants. Phosphatidylcholines 86-88 phospholipase D alpha 1 Arabidopsis thaliana 29-38 20107029-7 2010 Since phospholipase Dalpha1 (PLDalpha1) is a major enzyme promoting the hydrolysis of PC to PA, PLDalpha1 expression was examined and was observed to be higher in ACBP1 overexpressors than in acbp1 mutant plants. Phosphatidylcholines 86-88 acyl-CoA binding protein 1 Arabidopsis thaliana 163-168 20371992-3 2010 We have demonstrated that Abeta binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the liquid crystalline phase by using fluorescence and circular dichroism spectroscopy. Phosphatidylcholines 45-64 amyloid beta precursor protein Homo sapiens 26-31 20371992-5 2010 Tightly packed phosphatidylcholine membranes appear to serve as a platform for non-electrostatic binding and self-association of Abeta. Phosphatidylcholines 15-34 amyloid beta precursor protein Homo sapiens 129-134 20114052-8 2010 When incubated with reconstituted phosphatidylcholine bilayers, the E46K protein formed channels that are five times less conductive than those formed by wild-type alpha-syn, exhibit a higher selectivity for cations, and present an asymmetrical response to voltage and nonstop single-channel activity. Phosphatidylcholines 34-53 synuclein alpha Homo sapiens 164-173 20303856-6 2010 Although dianionic PA does not play a role in nAChR function, we found that both the stabilization of monoanionic PA and the concentration of other cations at the bilayer surface can account for changes in bilayer physical properties that are observed upon incorporation of the nAChR into 3:2 PC/PA membranes. Phosphatidylcholines 293-295 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 278-283 20042613-0 2010 StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria. Phosphatidylcholines 49-68 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 19931432-3 2010 PLD incubation of EY mainly converts phosphatidylcholine into phosphatidic acid (PA). Phosphatidylcholines 37-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 20024669-7 2010 Transient expression of GFP-fused TaAAPT1 and TaAAPT2 proteins in wheat and onion cells indicated they are localized to both the endoplasmic reticulum and Golgi apparatus, suggesting that the final synthesis of PE and PC via the CDP-choline/ethanolamine pathway occurs in these organella. Phosphatidylcholines 218-220 choline/ethanolaminephosphotransferase 1 Triticum aestivum 34-41 20018880-5 2010 CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis. Phosphatidylcholines 183-189 choline phosphotransferase 1 Homo sapiens 0-4 19931543-3 2010 For the ErbB2 TM helix inserted into phosphatidylcholine vesicles, the activating V664E mutation was found to induce a transverse shift involving the movement of the E residue toward the membrane surface. Phosphatidylcholines 37-56 erb-b2 receptor tyrosine kinase 2 Homo sapiens 8-13 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. Phosphatidylcholines 82-101 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 19895904-7 2010 To assess whether the reduced cellular association mediated by Lp-PLA2 was due to the hydrolysis of oxidized phosphatidylcholine (oxPC), we measured the concentration of lysophosphatidylcholine (lysoPC) in lipoprotein fractions after Lp-PLA2 treatment. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 63-70 19880374-0 2010 Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS. Phosphatidylcholines 80-99 solute carrier family 38, member 3 Mus musculus 33-37 19880374-0 2010 Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS. Phosphatidylcholines 80-99 solute carrier family 38, member 5 Mus musculus 42-46 19880374-1 2010 Endogenous phosphatidylcholine in biological membranes exists as isomers with acyl moieties at the sn-1 or sn-2 positions of the glycerol backbone. Phosphatidylcholines 11-30 solute carrier family 38, member 3 Mus musculus 99-103 19880374-1 2010 Endogenous phosphatidylcholine in biological membranes exists as isomers with acyl moieties at the sn-1 or sn-2 positions of the glycerol backbone. Phosphatidylcholines 11-30 solute carrier family 38, member 5 Mus musculus 107-111 19857456-2 2010 Among anionic phospholipids, phosphatidic acid (PA) and cardiolipin specifically increased the catalytic activities, membrane binding affinities, and thermal stabilities of both CYP1B1 proteins when phosphatidylcholine matrix was gradually replaced with these anionic phospholipids. Phosphatidylcholines 199-218 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 178-184 19880295-2 2010 In this study the influence of microenvironments such as pH, salt concentration, and surface charge on the secondary structure of a model protein, lysozyme, either in solution or entrapped in liposomes with various molar ratios of phosphatidylcholine (PC):cholesterol (Chol) was investigated. Phosphatidylcholines 252-254 lysozyme Homo sapiens 147-155 20044023-0 2010 Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme. Phosphatidylcholines 9-28 phospholipase A2 group IIA Homo sapiens 85-88 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. Phosphatidylcholines 82-101 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. Phosphatidylcholines 82-101 phosphatidylethanolamine N-methyltransferase Homo sapiens 209-213 21079819-10 2010 We demonstrate that recombinant hACBP effectively binds palmitoyl-CoA in vitro, undergoing a shift from a monomeric to a dimeric state, and that this ligand-binding ability is involved in erythrocytic membrane phosphatidylcholine (PC) remodeling but not in protein acylation. Phosphatidylcholines 210-229 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 32-37 19855431-5 2010 Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways. Phosphatidylcholines 52-71 phospholipase D2 Homo sapiens 75-91 19855431-5 2010 Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways. Phosphatidylcholines 52-71 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 166-195 21079819-10 2010 We demonstrate that recombinant hACBP effectively binds palmitoyl-CoA in vitro, undergoing a shift from a monomeric to a dimeric state, and that this ligand-binding ability is involved in erythrocytic membrane phosphatidylcholine (PC) remodeling but not in protein acylation. Phosphatidylcholines 231-233 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 32-37 19837049-0 2010 Synthesis of oligo(ethylene glycol) substituted phosphatidylcholines: secretory PLA2-targeted precursors of NSAID prodrugs. Phosphatidylcholines 48-68 phospholipase A2 group IB Homo sapiens 80-84 20410607-0 2010 Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. Phosphatidylcholines 107-126 solute carrier family 44 member 1 Homo sapiens 50-54 20410607-0 2010 Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. Phosphatidylcholines 107-126 solute carrier family 44 member 2 Homo sapiens 59-63 20462431-0 2010 Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells. Phosphatidylcholines 14-33 erb-b2 receptor tyrosine kinase 2 Homo sapiens 73-77 19851720-2 2010 The aim of this study was to determine the effectiveness of two types of OMP-associated phosphatidylcholine (PC) liposomal formulations (OMPs-PC, PC-OMPs) and of Zwittergent-based proteomicelles (OMPs-Z) in potentiating an anti-OMP systemic immune response in mice. Phosphatidylcholines 88-107 olfactory marker protein Mus musculus 73-76 20552438-11 2010 Although Rpe65 utilizes an all-trans-RE such as all-trans-retinyl palmitate (all-trans-RP) as substrate, it can be assayed in RPE homogenates by providing all-trans-ROL substrate and allowing the endogenous lecithin:retinol acyl transferase (LRAT) to synthesize all-trans-REs using fatty acids from phosphatidylcholine in the membranes. Phosphatidylcholines 299-318 RPE65, retinoid isomerohydrolase Gallus gallus 9-14 21614211-0 2010 Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A2under basal conditions. Phosphatidylcholines 31-50 plasminogen Mus musculus 6-17 21614211-1 2010 We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein. Phosphatidylcholines 125-144 plasminogen Homo sapiens 26-37 21614211-1 2010 We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein. Phosphatidylcholines 125-144 plasminogen Homo sapiens 39-42 19841481-1 2009 The Saccharomyces cerevisiae NTE1 gene encodes an evolutionarily conserved phospholipase B localized to the endoplasmic reticulum (ER) that degrades phosphatidylcholine (PC) generating glycerophosphocholine and free fatty acids. Phosphatidylcholines 149-168 lysophospholipase Saccharomyces cerevisiae S288C 29-33 19841481-2 2009 We show here that the activity of NTE1-encoded phospholipase B (Nte1p) prevents the attenuation of transcription of genes encoding enzymes involved in phospholipid synthesis in response to increased rates of PC synthesis by affecting the nuclear localization of the transcriptional repressor Opi1p. Phosphatidylcholines 208-210 lysophospholipase Saccharomyces cerevisiae S288C 34-38 19841481-2 2009 We show here that the activity of NTE1-encoded phospholipase B (Nte1p) prevents the attenuation of transcription of genes encoding enzymes involved in phospholipid synthesis in response to increased rates of PC synthesis by affecting the nuclear localization of the transcriptional repressor Opi1p. Phosphatidylcholines 208-210 lysophospholipase Saccharomyces cerevisiae S288C 64-69 19710104-8 2009 However, PC supplementation prevented the TNF-alpha-induced DNA fragmentation, cytochrome-c release and caspase-3 activity in control and CD hepatocytes. Phosphatidylcholines 9-11 tumor necrosis factor Rattus norvegicus 42-51 19615464-4 2009 The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity. Phosphatidylcholines 38-58 POU class 2 homeobox 3 Homo sapiens 133-139 19615464-4 2009 The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity. Phosphatidylcholines 38-58 phospholipase A2 group IB Homo sapiens 174-180 19615464-4 2009 The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity. Phosphatidylcholines 60-63 POU class 2 homeobox 3 Homo sapiens 133-139 19615464-4 2009 The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity. Phosphatidylcholines 60-63 phospholipase A2 group IB Homo sapiens 174-180 19615464-5 2009 In addition, HRASLS2 catalyzed N-acylation of PE to form N-acyl-PE and O-acylation of lyso PC to form PC. Phosphatidylcholines 91-93 phospholipase A and acyltransferase 2 Homo sapiens 13-20 19710104-8 2009 However, PC supplementation prevented the TNF-alpha-induced DNA fragmentation, cytochrome-c release and caspase-3 activity in control and CD hepatocytes. Phosphatidylcholines 9-11 caspase 3 Rattus norvegicus 104-113 19710104-10 2009 Furthermore, PC is identified as a new survival agent that reverses several TNFalpha-inducible responses that are likely to promote steatosis and necrosis. Phosphatidylcholines 13-15 tumor necrosis factor Rattus norvegicus 76-84 19888882-10 2009 SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride. Phosphatidylcholines 17-36 sarcolipin Mus musculus 0-3 19888882-10 2009 SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride. Phosphatidylcholines 17-36 sarcolipin Mus musculus 38-41 19888882-10 2009 SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride. Phosphatidylcholines 17-36 sarcolipin Mus musculus 38-41 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 5-35 19833868-5 2009 Here we show that a previously unrecognized enzyme, phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), encoded by the Arabidopsis ROD1 gene, is a major reaction for the transfer of 18:1 into PC for desaturation and also for the reverse transfer of 18:2 and 18:3 into the TAG synthesis pathway. Phosphatidylcholines 52-71 phosphatidic acid phosphatase-related / PAP2-like protein Arabidopsis thaliana 148-152 19833868-5 2009 Here we show that a previously unrecognized enzyme, phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), encoded by the Arabidopsis ROD1 gene, is a major reaction for the transfer of 18:1 into PC for desaturation and also for the reverse transfer of 18:2 and 18:3 into the TAG synthesis pathway. Phosphatidylcholines 209-211 phosphatidic acid phosphatase-related / PAP2-like protein Arabidopsis thaliana 148-152 19766625-7 2009 The perivascular infiltration of the neutrophil leukocytes and the intercellular adhesion molecule-1 (ICAM-1) expressions were reduced only by PC treatment. Phosphatidylcholines 143-145 intercellular adhesion molecule 1 Rattus norvegicus 67-100 19766625-7 2009 The perivascular infiltration of the neutrophil leukocytes and the intercellular adhesion molecule-1 (ICAM-1) expressions were reduced only by PC treatment. Phosphatidylcholines 143-145 intercellular adhesion molecule 1 Rattus norvegicus 102-108 19454128-5 2009 Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 53-71 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 37-41 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 42-47 19674157-8 2009 Consequently, ABCB4-mediated phosphatidylcholine translocation activity was significantly reduced when endogenous RACK1 expression was suppressed in HeLa cells. Phosphatidylcholines 29-48 ATP binding cassette subfamily B member 4 Homo sapiens 14-19 19674157-8 2009 Consequently, ABCB4-mediated phosphatidylcholine translocation activity was significantly reduced when endogenous RACK1 expression was suppressed in HeLa cells. Phosphatidylcholines 29-48 receptor for activated C kinase 1 Homo sapiens 114-119 19712054-5 2009 The ratios of the lyso derivatives of phosphatidyl choline, ethanolamine and serine obtained here together with the known distribution of these phospholipids among cell membranes, suggest that most PLA(2) hydrolysis takes place on the cell surface. Phosphatidylcholines 38-58 phospholipase A2 group IIA Homo sapiens 198-204 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 interleukin 1 beta Homo sapiens 209-213 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 interleukin 6 Homo sapiens 215-218 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 C-C motif chemokine ligand 2 Homo sapiens 220-224 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 C-C motif chemokine ligand 5 Homo sapiens 226-230 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 C-X-C motif chemokine ligand 10 Homo sapiens 232-238 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 intercellular adhesion molecule 1 Homo sapiens 244-249 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 22-41 interleukin 1 beta Homo sapiens 154-162 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 22-41 C-C motif chemokine ligand 2 Homo sapiens 171-175 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 43-45 interleukin 1 beta Homo sapiens 154-162 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 43-45 C-C motif chemokine ligand 2 Homo sapiens 171-175 19667981-4 2009 RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 17-24 19501189-6 2009 Purified recombinant cPLA2gamma catalyzed an acyltransferase reaction from one molecule of lysophosphatidylcholine (LPC) to another, forming phosphatidylcholine (PC). Phosphatidylcholines 95-114 phospholipase A2 group IVC Homo sapiens 21-31 19501189-6 2009 Purified recombinant cPLA2gamma catalyzed an acyltransferase reaction from one molecule of lysophosphatidylcholine (LPC) to another, forming phosphatidylcholine (PC). Phosphatidylcholines 117-119 phospholipase A2 group IVC Homo sapiens 21-31 19667981-4 2009 RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 40-82 19602573-1 2009 Among mammalian secreted phospholipases A2 (sPLA(2)s), the group X enzyme has the most potent hydrolyzing capacity toward phosphatidylcholine, the major phospholipid of cell membrane and lipoproteins. Phosphatidylcholines 122-141 phospholipase A2 group IID Homo sapiens 44-52 19589686-0 2009 Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester. Phosphatidylcholines 97-116 acyl-CoA binding protein 4 Arabidopsis thaliana 28-33 19667100-2 2009 The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway. Phosphatidylcholines 123-125 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 22-26 19589686-6 2009 Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine. Phosphatidylcholines 80-99 acyl-CoA binding protein 4 Arabidopsis thaliana 24-29 19589686-0 2009 Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester. Phosphatidylcholines 97-116 acyl-CoA binding protein 5 Arabidopsis thaliana 38-43 19589686-6 2009 Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine. Phosphatidylcholines 80-99 acyl-CoA binding protein 5 Arabidopsis thaliana 34-39 19589686-6 2009 Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine. Phosphatidylcholines 80-99 acyl-CoA-binding protein 6 Arabidopsis thaliana 49-54 19667100-2 2009 The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway. Phosphatidylcholines 123-125 phosphorylcholine cytidylyltransferase2 Arabidopsis thaliana 31-35 19667100-9 2009 PC levels were similarly maintained in both mutants and WS plants after 14 d at 2 degrees C, suggesting that either of the CCT genes is sufficient for PC biosynthesis at low temperature. Phosphatidylcholines 151-153 RNA polymerase II transcription mediator Arabidopsis thaliana 123-126 19589686-6 2009 Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine. Phosphatidylcholines 180-199 acyl-CoA binding protein 4 Arabidopsis thaliana 24-29 19589686-6 2009 Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine. Phosphatidylcholines 180-199 acyl-CoA binding protein 5 Arabidopsis thaliana 34-39 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. Phosphatidylcholines 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19632995-2 2009 The current view is that cPLA(2)alpha associates with intracellular/phosphatidylcholine-rich membranes strictly via hydrophobic interactions in response to an increase of intracellular calcium. Phosphatidylcholines 68-87 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 25-37 19759306-1 2009 The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho). Phosphatidylcholines 114-133 patatin-like phospholipase domain containing 6 Mus musculus 11-37 19759306-1 2009 The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho). Phosphatidylcholines 114-133 patatin-like phospholipase domain containing 6 Mus musculus 39-42 19700561-6 2009 A lipidomics approach revealed that At4g24160 has additional triacylglycerol lipase and phosphatidylcholine hydrolyzing enzymatic activities. Phosphatidylcholines 88-107 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 36-45 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. Phosphatidylcholines 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 19759306-1 2009 The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho). Phosphatidylcholines 135-141 patatin-like phospholipase domain containing 6 Mus musculus 11-37 19759306-1 2009 The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho). Phosphatidylcholines 135-141 patatin-like phospholipase domain containing 6 Mus musculus 39-42 19720032-0 2009 Interactions of the GM2 activator protein with phosphatidylcholine bilayers: a site-directed spin-labeling power saturation study. Phosphatidylcholines 47-66 ganglioside GM2 activator Homo sapiens 20-41 19720032-3 2009 Here, we used site-directed spin labeling with power saturation electron paramagnetic resonance to determine the surface-bound orientation of GM2AP upon phosphatidylcholine vesicles. Phosphatidylcholines 153-172 ganglioside GM2 activator Homo sapiens 142-147 19264150-2 2009 PLD catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA). Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19520976-2 2009 We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis. Phosphatidylcholines 131-133 phosphatidylethanolamine N-methyltransferase Mus musculus 50-94 19520976-2 2009 We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis. Phosphatidylcholines 131-133 phosphatidylethanolamine N-methyltransferase Mus musculus 96-100 19520976-7 2009 The molar ratio of PC/phosphatidylethanolamine in nascent VLDLs produced by Pemt(-/-)/Ldlr(-/-) mice was lower than in VLDLs in Pemt(+/+)/Ldlr(-/-) mice. Phosphatidylcholines 19-21 phosphatidylethanolamine N-methyltransferase Mus musculus 76-80 19520976-7 2009 The molar ratio of PC/phosphatidylethanolamine in nascent VLDLs produced by Pemt(-/-)/Ldlr(-/-) mice was lower than in VLDLs in Pemt(+/+)/Ldlr(-/-) mice. Phosphatidylcholines 19-21 low density lipoprotein receptor Mus musculus 86-90 19416650-1 2009 Phosphatidylinositol 4,5-bisphosphate-regulated phosphatidylcholine-specific phospholipase D is conserved from yeast to man. Phosphatidylcholines 48-67 phospholipase D Saccharomyces cerevisiae S288C 77-92 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19620706-0 2009 Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis. Phosphatidylcholines 88-107 patatin-like phospholipase domain containing 6 Mus musculus 24-50 19527682-4 2009 Bax-C slightly shifted upfield the (31)P resonances coming from phosphatidylglycerol and phosphatidylcholine. Phosphatidylcholines 89-108 BCL2 associated X, apoptosis regulator Homo sapiens 0-5 19527682-6 2009 Bax-C substantially decreased the T(1) relaxation times of phosphatidylglycerol and those of phosphatidylcholine when mixtured with phosphatidylglycerol, but T(1) values were not decreased when phosphatidylcholine was the only phospholipid present in the membrane. Phosphatidylcholines 93-112 BCL2 associated X, apoptosis regulator Homo sapiens 0-5 19527682-7 2009 (13)C-MAS-NMR showed that T(1) values were decreased when Bax-C was incorporated into the lipid vesicles and this reduction affected similarly to carbons located in different regions of the membrane when the only phospholipid present was phosphatidylcholine. Phosphatidylcholines 238-257 BCL2 associated X, apoptosis regulator Homo sapiens 58-63 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-104 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-109 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 158-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-104 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 158-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-109 19264893-7 2009 Levels of C32 and C34 n-3 pentaenoic and hexaenoic VLCFA in phosphatidylcholine increased whereas n-6 VLCFAs were depleted. Phosphatidylcholines 60-79 chemokine-like factor Mus musculus 10-13 19540357-2 2009 PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. Phosphatidylcholines 15-34 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19620706-2 2009 The authors investigate the effect of neuropathy target esterase inhibition in mouse nervous tissues in vitro on the homeostasis of phosphatidylcholine and lysophosphatidylcholine by treating the homogenates with tri-ortho-cresyl phosphate, paraoxon, paraoxon plus mipafox, and phenylmethylsulfonyl fluoride. Phosphatidylcholines 132-151 patatin-like phospholipase domain containing 6 Mus musculus 38-64 19794933-8 2009 On the other hand, PC only increased the secretion of apoA-IV in the presence of lipid micelles. Phosphatidylcholines 19-21 apolipoprotein A4 Homo sapiens 54-61 19702754-0 2009 A 10-kDa acyl-CoA-binding protein (ACBP) from Brassica napus enhances acyl exchange between acyl-CoA and phosphatidylcholine. Phosphatidylcholines 105-124 acyl-CoA-binding protein Brassica napus 35-39 19383981-0 2009 Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1. Phosphatidylcholines 16-35 lysophosphatidylcholine acyltransferase 1 Homo sapiens 45-86 18989753-1 2009 The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 165-184 lipin 2 Homo sapiens 26-31 18989753-1 2009 The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 165-184 lipin 3 Homo sapiens 36-41 19702754-3 2009 In vitro assays demonstrated that recombinant B. napus ACBP (rBnACBP) strongly increases the formation of phosphatidylcholine (PC) in the absence of added lysophosphatidylcholine in microsomes from DeltaYOR175c yeast expressing A. thaliana lysophosphatidylcholine acyltransferase (AthLPCAT) cDNA or in microsomes from microspore-derived cell suspension cultures of B. napus L. cv. Phosphatidylcholines 106-125 acyl-CoA-binding protein Brassica napus 55-59 19657017-4 2009 When expressed in Saccharomyces cerevisiae, FetA localizes partially to the plasma membrane resulting in increased internalization of NBD-labeled phosphatidylethanolamine and phosphatidylcholine, supporting a role for FetA in the inward lipid translocation across cellular membranes. Phosphatidylcholines 175-194 ATPase, class I, type 8B, member 5 Mus musculus 44-48 19646743-7 2009 Knockdown of Cept1, required for phosphatidylcholine synthesis, suppressed PPARalpha-dependent gene expression. Phosphatidylcholines 33-52 choline/ethanolamine phosphotransferase 1 Homo sapiens 13-18 19646743-7 2009 Knockdown of Cept1, required for phosphatidylcholine synthesis, suppressed PPARalpha-dependent gene expression. Phosphatidylcholines 33-52 peroxisome proliferator activated receptor alpha Homo sapiens 75-84 19289606-4 2009 Moreover, the interaction of Hsp70 with PS was demonstrated in artificial unilamellar phosphatidylcholine/ phosphatidylserine (PC/PS) liposomes at the physiological ratio of 8/2. Phosphatidylcholines 86-105 heat shock protein family A (Hsp70) member 4 Homo sapiens 29-34 19215923-0 2009 Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. Phosphatidylcholines 4-23 toll-like receptor 4 Mus musculus 34-38 19215923-0 2009 Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. Phosphatidylcholines 4-23 mast cell protease 1 Mus musculus 48-53 19215923-3 2009 The aims of this study are to confirm the role of SFAs in TLR4-mediated inflammatory signaling in vascular cells and to propose soy phosphatidylcholine (SPC) as an effective inhibitor against TLR4-mediated agonists. Phosphatidylcholines 132-151 toll-like receptor 4 Rattus norvegicus 192-196 19289606-6 2009 In contrast, only a weak Hsp70 interaction was detected in phosphatidylcholine/phosphatidylglycerol (PC/PG) liposomes, thus demonstrating that the interaction was not a charge-related effect. Phosphatidylcholines 59-78 heat shock protein family A (Hsp70) member 4 Homo sapiens 25-30 19074371-4 2009 However, Cav1(-/-)-deficient cells did have a higher proportion of sphingomyelin, decreased abundance of unsaturated phospholipids, and a trend toward shorter fatty acid chains in phosphatidylcholine. Phosphatidylcholines 180-199 caveolin 1, caveolae protein Mus musculus 9-13 19219625-1 2009 Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. Phosphatidylcholines 67-86 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 110-152 19542364-4 2009 Pyk2 was activated through phosphatidylcholine-specific phospholipase C (PC-PLC)-, protein kinase C (PKC)-, and Src-regulated pathways. Phosphatidylcholines 27-46 protein tyrosine kinase 2 beta Homo sapiens 0-4 19351971-7 2009 Electrospray ionization mass spectrometric analysis of phospholipids in Sf9 cells expressing LPCAT3 showed a relative increase in phosphatidylcholine containing saturated acyl chains and a decrease in phosphatidylcholine containing unsaturated acyl chains. Phosphatidylcholines 130-149 lysophosphatidylcholine acyltransferase 3 Homo sapiens 93-99 19351971-7 2009 Electrospray ionization mass spectrometric analysis of phospholipids in Sf9 cells expressing LPCAT3 showed a relative increase in phosphatidylcholine containing saturated acyl chains and a decrease in phosphatidylcholine containing unsaturated acyl chains. Phosphatidylcholines 201-220 lysophosphatidylcholine acyltransferase 3 Homo sapiens 93-99 19594939-0 2009 TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. Phosphatidylcholines 76-95 tumor necrosis factor Homo sapiens 0-9 19594939-5 2009 It could be demonstrated that the exogenous application of PC inhibits membrane-dependent actin assembly and TNF-alpha-induced nuclear NF-kappaB activation. Phosphatidylcholines 59-61 tumor necrosis factor Homo sapiens 109-118 19594939-11 2009 RESULTS: The exogenous addition of all PC species tested significantly inhibited TNF-alpha-induced pro-inflammatory signalling. Phosphatidylcholines 39-41 tumor necrosis factor Homo sapiens 81-90 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 intercellular adhesion molecule 1 Homo sapiens 31-37 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 C-X-C motif chemokine ligand 10 Homo sapiens 39-44 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 C-C motif chemokine ligand 2 Homo sapiens 46-51 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 tumor necrosis factor Homo sapiens 53-62 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 matrix metallopeptidase 1 Homo sapiens 67-72 19594939-16 2009 CONCLUSION: PC induces a prolonged inhibition of TNF-alpha-induced pro-inflammatory signalling. Phosphatidylcholines 12-14 tumor necrosis factor Homo sapiens 49-58 19219625-1 2009 Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. Phosphatidylcholines 67-86 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 154-158 19219625-1 2009 Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. Phosphatidylcholines 88-90 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 110-152 19219625-1 2009 Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. Phosphatidylcholines 88-90 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 154-158 19219625-6 2009 To conclude, chronic ethanol consumption impairs PC generation via the PEMT pathway resulting in diminished VLDL secretion which contributes to the development of hepatic steatosis. Phosphatidylcholines 49-51 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 71-75 19219625-7 2009 By increasing PEMT-mediated PC generation, betaine results in increased fat export from the liver and attenuates the development of alcoholic fatty liver. Phosphatidylcholines 28-30 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 14-18 19349639-3 2009 It is hypothesized that homeostasis of phosphatidylcholine (PC) and/or lysophosphatidylcholine (LPC) in mice might be disrupted by the OPs since NTE and other phospholipases could be inhibited. Phosphatidylcholines 60-62 patatin-like phospholipase domain containing 6 Mus musculus 145-148 19366698-1 2009 Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho). Phosphatidylcholines 184-203 phospholipid N-methyltransferase Glycine max 0-32 19366698-1 2009 Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho). Phosphatidylcholines 184-203 phospholipid N-methyltransferase Glycine max 34-38 19366698-1 2009 Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho). Phosphatidylcholines 205-211 phospholipid N-methyltransferase Glycine max 0-32 19366698-1 2009 Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho). Phosphatidylcholines 205-211 phospholipid N-methyltransferase Glycine max 34-38 19540431-7 2009 In addition, the ORX-A- and ghrelin-induced depolarizations were both blocked by D609, a phosphatidylcholine-specific phospholipase C (PLC) inhibitor. Phosphatidylcholines 89-108 hypocretin neuropeptide precursor Rattus norvegicus 17-20 19540431-7 2009 In addition, the ORX-A- and ghrelin-induced depolarizations were both blocked by D609, a phosphatidylcholine-specific phospholipase C (PLC) inhibitor. Phosphatidylcholines 89-108 ghrelin and obestatin prepropeptide Rattus norvegicus 28-35 19327342-0 2009 Cytochrome c induces lipid demixing in weakly charged phosphatidylcholine/phosphatidylglycerol model membranes as evidenced by resonance energy transfer. Phosphatidylcholines 54-73 cytochrome c, somatic Homo sapiens 0-12 19327342-1 2009 Resonance energy transfer (RET) between anthrylvinyl-labeled phosphatidylcholine (AV-PC) or phosphatidylglycerol (AV-PG) as donors and the heme groups of cytochrome c (cyt c) as acceptors was examined in PC/PG model membranes containing 10, 20 or 40 mol% PG with an emphasis on evaluating lipid demixing caused by this protein. Phosphatidylcholines 61-80 cytochrome c, somatic Homo sapiens 154-166 18837012-5 2009 The MDR1-MDCKII cell membrane has lower ratios of: phospholipid to cholesterol, unsaturated to saturated acyl chains, and phosphatidyl-choline (PC) to sphingomyelin (SM) than brain endothelial cells, making it a poor passive permeability model for BBB. Phosphatidylcholines 122-142 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 18837012-5 2009 The MDR1-MDCKII cell membrane has lower ratios of: phospholipid to cholesterol, unsaturated to saturated acyl chains, and phosphatidyl-choline (PC) to sphingomyelin (SM) than brain endothelial cells, making it a poor passive permeability model for BBB. Phosphatidylcholines 144-146 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 18937360-3 2009 P-gp was reconstituted in egg-phosphatidylcholine (PhC) liposomes with or without cholesterol, 1,2-dipalmitoyl-phosphatidylcholine (DPPC), alpha-tocopherol (alpha-Toc) or 2,2,5,7,8-pentamethyl-6-chromanol (PMC). Phosphatidylcholines 30-49 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19425005-0 2009 Investigation of C-reactive protein binding to phosphatidyl choline by CZE and ESI-mass analysis. Phosphatidylcholines 47-67 C-reactive protein Homo sapiens 17-35 19098306-2 2009 However, CCTalpha is cytoplasmic in cells with increased capacity for PtdCho synthesis and following acute activation, suggesting that nuclear export is linked to activation. Phosphatidylcholines 70-76 choline-phosphate cytidylyltransferase A Cricetulus griseus 9-17 19114730-5 2009 Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion. Phosphatidylcholines 52-54 GLI family zinc finger 2 Homo sapiens 72-77 19114730-5 2009 Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion. Phosphatidylcholines 52-54 intercellular adhesion molecule 1 Homo sapiens 95-101 19420237-3 2009 We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis. Phosphatidylcholines 229-248 X-box binding protein 1 Homo sapiens 50-54 19420237-3 2009 We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis. Phosphatidylcholines 229-248 X-box binding protein 1 Homo sapiens 78-82 19420237-3 2009 We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis. Phosphatidylcholines 250-256 X-box binding protein 1 Homo sapiens 50-54 19420237-3 2009 We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis. Phosphatidylcholines 250-256 X-box binding protein 1 Homo sapiens 78-82 19420237-6 2009 Overexpression of active ATF6alpha induces PtdCho biosynthesis and modulates the CDP-choline pathway differently than does enforced expression of XBP1(S). Phosphatidylcholines 43-49 activating transcription factor 6 Homo sapiens 25-34 19236939-4 2009 The biosynthesis of phosphatidylcholine (PC) is impaired in the hindlimbs of Chkb -/- mice, with an accumulation of choline and decreased amount of phosphocholine. Phosphatidylcholines 20-39 choline kinase beta Mus musculus 77-81 19236939-4 2009 The biosynthesis of phosphatidylcholine (PC) is impaired in the hindlimbs of Chkb -/- mice, with an accumulation of choline and decreased amount of phosphocholine. Phosphatidylcholines 41-43 choline kinase beta Mus musculus 77-81 19236939-10 2009 Injection of CDP-choline increased PC content of hindlimb muscle and decreased creatine kinase activity in plasma of Chkb -/- mice. Phosphatidylcholines 35-37 cut-like homeobox 1 Mus musculus 13-16 19236939-11 2009 We conclude that the hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated PC biosynthesis and enhanced catabolism of PC. Phosphatidylcholines 87-89 choline kinase beta Mus musculus 52-56 19236939-11 2009 We conclude that the hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated PC biosynthesis and enhanced catabolism of PC. Phosphatidylcholines 130-132 choline kinase beta Mus musculus 52-56 19184454-6 2009 This last result was obtained through the study of structured phosphatidylcholine selective deacylation using a phospholipase A2. Phosphatidylcholines 62-81 phospholipase A2 group IB Homo sapiens 112-128 19098306-1 2009 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes. Phosphatidylcholines 114-133 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 19098306-1 2009 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes. Phosphatidylcholines 114-133 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-55 19098306-1 2009 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes. Phosphatidylcholines 135-141 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 19098306-1 2009 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes. Phosphatidylcholines 135-141 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-55 19415669-0 2009 Physiological phosphatidylcholine protects bovine beta-lactoglobulin from simulated gastrointestinal proteolysis. Phosphatidylcholines 14-33 beta-lactoglobulin Bos taurus 50-68 19018976-1 2009 BACKGROUND AND AIMS: Mutations in the gene encoding the ABCB4 [adenosine triphosphate (ATP)-binding cassette, sub-family B (MDR/TAP), member 4] transporter lower phosphatidylcholine output into bile and contribute to cholesterol gallstone formation by decreasing the solubility of cholesterol in bile. Phosphatidylcholines 162-181 ATP binding cassette subfamily B member 4 Homo sapiens 56-61 19415669-1 2009 We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis. Phosphatidylcholines 35-54 beta-lactoglobulin Bos taurus 88-106 19415669-1 2009 We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis. Phosphatidylcholines 35-54 beta-lactoglobulin Bos taurus 108-115 19415669-1 2009 We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis. Phosphatidylcholines 56-58 beta-lactoglobulin Bos taurus 88-106 19415669-1 2009 We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis. Phosphatidylcholines 56-58 beta-lactoglobulin Bos taurus 108-115 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 113-118 19342656-5 2009 By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline. Phosphatidylcholines 156-176 CD1d molecule Homo sapiens 59-63 19342656-5 2009 By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline. Phosphatidylcholines 289-309 CD1d molecule Homo sapiens 59-63 19342656-5 2009 By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline. Phosphatidylcholines 289-309 CD1d molecule Homo sapiens 218-222 19342656-6 2009 The secreted soluble version of CD1d, in contrast, lacks detectable phosphatidyl choline and the only detectable associated lipid is sphingomyelin. Phosphatidylcholines 68-88 CD1d molecule Homo sapiens 32-36 19714900-0 2009 Specular neutron reflectivity studies of the interaction of cytochrome c with supported phosphatidylcholine bilayers doped with phosphatidylserine. Phosphatidylcholines 88-107 cytochrome c, somatic Homo sapiens 60-72 19164803-5 2009 Phosphatidylcholine on LDL from LDLR(-/-) mice fed either a chow or Western diet was hydrolyzed to a greater extent (61.1+/-0.4% and 45.3+/-4.6%) than the corresponding fractions from apoE(-/-) mice (41.7+/-3.6% and 39.4+/-1.2%). Phosphatidylcholines 0-19 low density lipoprotein receptor Mus musculus 32-36 19164803-5 2009 Phosphatidylcholine on LDL from LDLR(-/-) mice fed either a chow or Western diet was hydrolyzed to a greater extent (61.1+/-0.4% and 45.3+/-4.6%) than the corresponding fractions from apoE(-/-) mice (41.7+/-3.6% and 39.4+/-1.2%). Phosphatidylcholines 0-19 apolipoprotein E Mus musculus 184-188 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 121-143 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 145-149 19389349-1 2009 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 33-52 Phospholipase D Drosophila melanogaster 17-20 19416660-4 2009 Here we show that purified recombinant Drosophila tafazzin exchanges acyl groups between cardiolipin and phosphatidylcholine by a combination of forward and reverse transacylations. Phosphatidylcholines 105-124 Tafazzin Drosophila melanogaster 50-58 19351232-1 2009 Citicoline (cytidine-5"-diphosphocholine or CDP-choline) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischemia to free fatty acids and free radicals. Phosphatidylcholines 103-122 cut like homeobox 1 Homo sapiens 44-47 19346733-9 2009 The present study shows that the common SNP (C to T substitution) in the first intron of the FACL4 gene is associated with altered FA composition of plasma phosphatidylcholines in patients with MetS. Phosphatidylcholines 156-176 acyl-CoA synthetase long chain family member 4 Homo sapiens 93-98 19047760-3 2009 Here, we show that recombinant H-Rev107s from rat, human, and mouse possess phospholipase (PL) A1 or A2 activity toward phosphatidylcholine (PC). Phosphatidylcholines 120-139 phospholipase A and acyltransferase 3 Rattus norvegicus 31-39 19047760-3 2009 Here, we show that recombinant H-Rev107s from rat, human, and mouse possess phospholipase (PL) A1 or A2 activity toward phosphatidylcholine (PC). Phosphatidylcholines 141-143 phospholipase A and acyltransferase 3 Rattus norvegicus 31-39 19250629-5 2009 Abhd2 deficiency resulted in a decreased level of phosphatidylcholine in the bronchoalveolar lavage. Phosphatidylcholines 50-69 abhydrolase domain containing 2 Mus musculus 0-5 19302798-2 2009 The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1). Phosphatidylcholines 88-107 synaptotagmin 1 Homo sapiens 24-28 19302798-2 2009 The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1). Phosphatidylcholines 88-107 secretoglobin family 2B member 3, pseudogene Homo sapiens 30-33 19270412-0 2009 Involvement of LEM3/ROS3 in the uptake of phosphatidylcholine with short acyl chains in Saccharomyces cerevisiae. Phosphatidylcholines 42-61 Lem3p Saccharomyces cerevisiae S288C 15-19 19270412-0 2009 Involvement of LEM3/ROS3 in the uptake of phosphatidylcholine with short acyl chains in Saccharomyces cerevisiae. Phosphatidylcholines 42-61 Lem3p Saccharomyces cerevisiae S288C 20-24 19141610-0 2009 The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. Phosphatidylcholines 55-74 karyopherin alpha Saccharomyces cerevisiae S288C 4-9 19141610-0 2009 The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. Phosphatidylcholines 55-74 karyopherin beta Saccharomyces cerevisiae S288C 10-15 19141610-3 2009 In S. cerevisiae, the rate-determining step in the synthesis of phosphatidylcholine via the CDP-choline pathway is catalyzed by Pct1. Phosphatidylcholines 64-83 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 128-132 19141610-9 2009 Diminution of Kap95 function resulted in almost complete ablation of phosphatidylcholine synthesis under conditions where Pct1 was extranuclear. Phosphatidylcholines 69-88 karyopherin beta Saccharomyces cerevisiae S288C 14-19 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 125-144 Lem3p Saccharomyces cerevisiae S288C 13-17 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 125-144 Lem3p Saccharomyces cerevisiae S288C 18-22 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 125-144 Lem3p Saccharomyces cerevisiae S288C 71-76 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 146-148 Lem3p Saccharomyces cerevisiae S288C 13-17 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 146-148 Lem3p Saccharomyces cerevisiae S288C 18-22 19270412-3 2009 Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains. Phosphatidylcholines 146-148 Lem3p Saccharomyces cerevisiae S288C 71-76 19129178-1 2009 A protein known to regulate both lipid metabolism and vesicular transport is the phosphatidylcholine/phosphatidylinositol transfer protein Sec14 of Saccharomyces cerevisiae. Phosphatidylcholines 81-100 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 139-144 18980580-0 2009 Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope. Phosphatidylcholines 24-43 choline-phosphate cytidylyltransferase A Cricetulus griseus 63-108 19159281-8 2009 Phospholipase A2, which hydrolyses phosphatidylcholine to Acyl-GPC, is a known modifier gene of the model phenotype (Mom1), and altered expression of choline phospholipid enzymes has been reported in gut tissue from Apc(Min/+) mice. Phosphatidylcholines 35-54 phospholipase A2, group IB, pancreas Mus musculus 0-16 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 172-174 phosphatidylserine synthase 1 Homo sapiens 97-101 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 172-174 phosphatidylserine synthase 1 Homo sapiens 103-116 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 172-174 phosphatidylserine synthase 2 Homo sapiens 122-126 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 176-195 phosphatidylserine synthase 1 Homo sapiens 97-101 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 176-195 phosphatidylserine synthase 1 Homo sapiens 103-116 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. Phosphatidylcholines 176-195 phosphatidylserine synthase 2 Homo sapiens 122-126 19014349-4 2009 The purified PSS2 was shown to catalyse the conversion of PE, but not PC, into PS, this being consistent with the substrate specificity observed in intact cells. Phosphatidylcholines 70-72 phosphatidylserine synthase 2 Homo sapiens 13-17 19014349-5 2009 On the other hand, the purified PSS1 was shown to catalyse the conversion of both PC and PE into PS, although PSS1 in intact cells had been shown not to contribute to the conversion of PE into PS to a significant extent. Phosphatidylcholines 82-84 phosphatidylserine synthase 1 Homo sapiens 32-36 18983994-1 2009 The effect of cytochrome c (cyt c) on degradation of cardiolipin in its polar part was investigated in cardiolipin/phosphatidylcholine (CL/PC) liposomes incubated with cyt c/H(2)O(2)/and (or) ascorbate by high-performance thin layer chromatography and MALDI-TOF mass spectrometry. Phosphatidylcholines 115-134 cytochrome c, somatic Homo sapiens 14-26 18983994-1 2009 The effect of cytochrome c (cyt c) on degradation of cardiolipin in its polar part was investigated in cardiolipin/phosphatidylcholine (CL/PC) liposomes incubated with cyt c/H(2)O(2)/and (or) ascorbate by high-performance thin layer chromatography and MALDI-TOF mass spectrometry. Phosphatidylcholines 115-134 cytochrome c, somatic Homo sapiens 28-33 19579625-5 2009 Expressions of caspase-8, -3 and PARP after phosphatidylcholine stimulation were examined by immunoblotting. Phosphatidylcholines 44-63 caspase 8 Homo sapiens 15-28 19579625-5 2009 Expressions of caspase-8, -3 and PARP after phosphatidylcholine stimulation were examined by immunoblotting. Phosphatidylcholines 44-63 collagen type XI alpha 2 chain Homo sapiens 33-37 19579625-9 2009 Fas or TNF-alpha ligand followed by phosphatidylcholine stimulation significantly increased apoptotic cells more than by phosphatidylcholine alone (p < 0.05). Phosphatidylcholines 121-140 tumor necrosis factor Homo sapiens 7-16 19579625-11 2009 Phosphatidylcholine was assumed to reduce hepatic carcinogenesis by apoptosis induction via the death ligands (Fas and/or TNF-alpha) pathway followed by caspase-8 and -3 inductions. Phosphatidylcholines 0-19 tumor necrosis factor Homo sapiens 122-131 19579625-11 2009 Phosphatidylcholine was assumed to reduce hepatic carcinogenesis by apoptosis induction via the death ligands (Fas and/or TNF-alpha) pathway followed by caspase-8 and -3 inductions. Phosphatidylcholines 0-19 caspase 8 Homo sapiens 153-169 18980580-3 2009 [(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope). Phosphatidylcholines 150-156 choline-phosphate cytidylyltransferase A Cricetulus griseus 195-203 18980580-3 2009 [(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope). Phosphatidylcholines 150-156 choline-phosphate cytidylyltransferase A Cricetulus griseus 205-250 18980580-7 2009 25OH activated CCTalpha in CHO-SCAP D443N cells leading to a transient increase in PtdCho synthesis and accumulation of CDP-choline. Phosphatidylcholines 83-89 choline-phosphate cytidylyltransferase A Cricetulus griseus 15-23 18980580-7 2009 25OH activated CCTalpha in CHO-SCAP D443N cells leading to a transient increase in PtdCho synthesis and accumulation of CDP-choline. Phosphatidylcholines 83-89 sterol regulatory element-binding protein cleavage-activating protein Cricetulus griseus 31-35 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 48-52 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidylcholines 105-124 synuclein alpha Homo sapiens 44-52 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 19059204-4 2009 It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA. Phosphatidylcholines 233-252 phospholamban Homo sapiens 169-172 19059204-4 2009 It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA. Phosphatidylcholines 233-252 phospholamban Homo sapiens 174-181 19059204-4 2009 It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA. Phosphatidylcholines 254-256 phospholamban Homo sapiens 169-172 19059204-4 2009 It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA. Phosphatidylcholines 254-256 phospholamban Homo sapiens 174-181 19059204-5 2009 Functional measurements of SERCA in sarcoplasmic reticulum (SR) vesicles, planar SR membranes and reconstituted into PC/PG membranes indicate that PLB1-23 lowers the maximal rate of ATP hydrolysis by acting at the cytoplasmic face of the enzyme. Phosphatidylcholines 117-119 phospholamban Homo sapiens 147-154 19059242-3 2009 Cytochrome c peroxidase activity and Trp59 fluorescence increase in the sequence of phosphatidyl choline (PC)-->phosphatidylserine (PS)-->cardiolipin (CL)-->phosphatidic acid (PA). Phosphatidylcholines 84-104 cytochrome c, somatic Homo sapiens 0-12 19059242-3 2009 Cytochrome c peroxidase activity and Trp59 fluorescence increase in the sequence of phosphatidyl choline (PC)-->phosphatidylserine (PS)-->cardiolipin (CL)-->phosphatidic acid (PA). Phosphatidylcholines 106-108 cytochrome c, somatic Homo sapiens 0-12 18983488-5 2009 In eight of these volunteers, an infusion of human apoAI reconstituted with phosphatidylcholine (apoAI-PC; 80 mg kg(-1) body weight) preceded rhCRP infusion. Phosphatidylcholines 76-95 apolipoprotein A1 Homo sapiens 51-56 18983488-5 2009 In eight of these volunteers, an infusion of human apoAI reconstituted with phosphatidylcholine (apoAI-PC; 80 mg kg(-1) body weight) preceded rhCRP infusion. Phosphatidylcholines 76-95 apolipoprotein A1 Homo sapiens 97-102 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 steroidogenic acute regulatory protein Homo sapiens 112-118 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 3 Homo sapiens 119-127 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 5 Homo sapiens 129-135 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 phosphatidylcholine transfer protein Homo sapiens 137-143 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 10 Homo sapiens 144-151 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 10 Homo sapiens 153-160 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 ceramide transporter 1 Homo sapiens 165-172 18988890-9 2009 Moreover, EL expression was positively associated with lysophosphatidylcholine production and inversely with phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin levels. Phosphatidylcholines 59-78 lipase G, endothelial type Homo sapiens 10-12 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 65-69 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 208-213 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 339-344 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 479-484 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 479-484 19102680-4 2009 Analysis of the data using a kinetic model has suggested an allosteric mechanism for the rate increase of hPLA2 by cholate and also for the rate-lowering effect by certain bile salts or cembranoids on the cholate-activated hPLA2 hydrolysis of phosphatidylcholine vesicles. Phosphatidylcholines 243-262 phospholipase A2 group IB Homo sapiens 106-111 18974965-3 2009 In the present study, we report that lysophosphatidylcholine acyltransferase 1 (LPCAT1; NM_024830.3), the enzyme that converts lysophosphatidylcholine into phosphatidylcholine, was highly overexpressed in colorectal adenocarcinomas when compared to normal mucosas. Phosphatidylcholines 41-60 lysophosphatidylcholine acyltransferase 1 Homo sapiens 80-86 18974965-7 2009 In cultured cells, overexpressed LPCAT1 enhanced the incorporation of [(14)C]palmitate into phosphatidylcholine. Phosphatidylcholines 92-111 lysophosphatidylcholine acyltransferase 1 Homo sapiens 33-39 18974965-9 2009 We conclude that LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy. Phosphatidylcholines 84-103 lysophosphatidylcholine acyltransferase 1 Homo sapiens 17-23 19102680-4 2009 Analysis of the data using a kinetic model has suggested an allosteric mechanism for the rate increase of hPLA2 by cholate and also for the rate-lowering effect by certain bile salts or cembranoids on the cholate-activated hPLA2 hydrolysis of phosphatidylcholine vesicles. Phosphatidylcholines 243-262 phospholipase A2 group IB Homo sapiens 223-228 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 121-140 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidylcholines 97-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidylcholines 97-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19116882-8 2009 DHA and DHA-rich phosphatidylcholine decreased Bcl-2 level in HT-29 and Caco-2 cells. Phosphatidylcholines 17-36 BCL2 apoptosis regulator Homo sapiens 47-52 18495456-8 2009 However, the MTHFR C677T genotype, alone or together with a diet, influenced betaine (P=.03) and phosphatidylcholine (P=.03). Phosphatidylcholines 97-116 methylenetetrahydrofolate reductase Homo sapiens 13-18 18988706-4 2009 Here, we report the first crystal structure of the SF-1 LBD bound by the exchanged phosphatidylcholine. Phosphatidylcholines 83-102 splicing factor 1 Homo sapiens 51-55 19016452-11 2009 In addition, this study presents evidence suggesting a specific role for phospholipase A2-mediated PtdCho catabolism. Phosphatidylcholines 99-105 phospholipase A2, group IB, pancreas Mus musculus 73-89 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 121-140 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 142-144 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 142-144 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 18842588-2 2008 Mice that lack PEMT have reduced plasma levels of PC and cholesterol in high density lipoproteins (HDL). Phosphatidylcholines 50-52 phosphatidylethanolamine N-methyltransferase Mus musculus 15-19 18842588-6 2008 Moreover, hepatocytes isolated from Pemt(-/-) mice released cholesterol and PC into the medium as efficiently as did hepatocytes from Pemt(+/+) mice. Phosphatidylcholines 76-78 phosphatidylethanolamine N-methyltransferase Mus musculus 36-40 18842580-5 2008 mpk1Delta cells also exhibit severe defects in lipid metabolism, including an abnormal accumulation of phosphatidylcholine, diacylglycerol, triacylglycerol, and free sterols, as well as aberrant turnover of phosphatidylcholine. Phosphatidylcholines 103-122 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 0-4 18835908-0 2008 Behavioral differences between phosphatidic acid and phosphatidylcholine in the presence of the nicotinic acetylcholine receptor. Phosphatidylcholines 53-72 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 96-128 18931395-7 2008 The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p. Phosphatidylcholines 77-96 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 284-289 18931395-7 2008 The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p. Phosphatidylcholines 77-96 drug-responsive transcription factor PDR3 Saccharomyces cerevisiae S288C 294-299 18842580-5 2008 mpk1Delta cells also exhibit severe defects in lipid metabolism, including an abnormal accumulation of phosphatidylcholine, diacylglycerol, triacylglycerol, and free sterols, as well as aberrant turnover of phosphatidylcholine. Phosphatidylcholines 207-226 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 0-4 18762160-1 2008 Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro. Phosphatidylcholines 161-181 phosphatidylcholine transfer protein Mus musculus 0-36 18762160-1 2008 Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro. Phosphatidylcholines 161-181 phosphatidylcholine transfer protein Mus musculus 38-43 18762160-1 2008 Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro. Phosphatidylcholines 161-181 phosphatidylcholine transfer protein Mus musculus 65-71 18762160-3 2008 To begin to address the relationship between activity in vitro and biological function, we undertook a high-throughput screen to identify small-molecule inhibitors of the phosphatidylcholine transfer activity of PC-TP. Phosphatidylcholines 171-190 phosphatidylcholine transfer protein Mus musculus 212-217 18629440-5 2008 hPLSCR1 showed higher rates of scrambling activity for phosphatidylethanolamine than phosphatidylcholine. Phosphatidylcholines 85-104 phospholipid scramblase 1 Homo sapiens 0-7 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18791037-2 2008 Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine. Phosphatidylcholines 188-207 lipin 1 Homo sapiens 0-27 18791037-2 2008 Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine. Phosphatidylcholines 188-207 lipin 1 Homo sapiens 29-33 18773301-6 2008 Lipid profile analysis further revealed that an acbp4 knockout mutant showed decreases in membrane lipids (digalactosyldiacylglycerol, monogalactosyldiacylglycerol, phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol) while acbp4-complemented lines attained levels similar to wild type, suggesting that ACBP4 plays a role in the biosynthesis of membrane lipids including galactolipids and phospholipids. Phosphatidylcholines 165-184 acyl-CoA binding protein 4 Arabidopsis thaliana 48-53 19017977-11 2008 LPLA(2)(-/-) alveolar macrophages are characterized by marked accumulation of phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 78-97 phospholipase A2, group XV Mus musculus 0-7 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 142-145 19704440-3 2008 Lipid analyses on cold-acclimated freezing-treated ACBP6-overexpressors revealed a decline in phosphatidylcholine (PC) and an elevation of phosphatidic acid (PA) in comparison to wild type. Phosphatidylcholines 94-113 acyl-CoA-binding protein 6 Arabidopsis thaliana 51-56 18784085-2 2008 When protein S was added to phosphatidylcholine/phosphatidylserine (PC/PS, 4:1) vesicle-bound DEGR-fXa(i), the anisotropy of the dansyl moiety was altered from 0.219 +/- 0.002 to 0.245 +/- 0.003. Phosphatidylcholines 28-47 coagulation factor X Homo sapiens 99-102 18922025-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC). Phosphatidylcholines 169-188 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 0-39 18922025-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC). Phosphatidylcholines 169-188 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 41-44 18922025-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC). Phosphatidylcholines 190-192 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 0-39 18922025-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC). Phosphatidylcholines 190-192 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 41-44 18930839-0 2008 Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways. Phosphatidylcholines 106-125 phospholipid phosphatase 6 Homo sapiens 28-63 18930839-8 2008 PA-PSP overexpression, but not LPRP-A, accelerated the synthesis of phosphatidylcholine and caused accumulation of triacylglycerol with concomitant decrease in the rate of phosphatidylinositol synthesis. Phosphatidylcholines 68-87 phospholipid phosphatase 6 Homo sapiens 0-6 18930839-9 2008 Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol. Phosphatidylcholines 113-132 phosphate cytidylyltransferase 1A, choline Homo sapiens 22-67 18930839-9 2008 Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol. Phosphatidylcholines 113-132 phospholipid phosphatase 6 Homo sapiens 73-79 18930839-9 2008 Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol. Phosphatidylcholines 113-132 phospholipid phosphatase 6 Homo sapiens 103-109 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2 group IID Homo sapiens 90-96 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group III Mus musculus 185-191 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group V Mus musculus 206-212 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group X Mus musculus 217-224 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group IIF Mus musculus 248-255 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 279-286 18801741-5 2008 In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. Phosphatidylcholines 109-128 phospholipase A2, group IIE Mus musculus 291-298 18755140-3 2008 Fluorescence and circular dichroism spectra have clearly shown that Abeta binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the ripple gel or liquid crystalline phase, indicating the importance of the tight lipid packing characteristic of the lamellar gel phase. Phosphatidylcholines 87-106 amyloid beta precursor protein Homo sapiens 68-73 18755140-6 2008 The flat surface of tightly packed phosphatidylcholine membranes appears to serve as a platform for non-electrostatic binding and self-association of Abeta. Phosphatidylcholines 35-54 amyloid beta precursor protein Homo sapiens 150-155 19002082-1 2008 Phosphatidylcholine-specific phospholipase C (PC-PLC) catalyzes the hydrolysis of the ester linkage between glycerol and phosphate in phosphocholine (PC) and other phosphatides, such as sphingomylin (SM) and phosphatidylethanolamine (PE). Phosphatidylcholines 0-19 heparan sulfate proteoglycan 2 Homo sapiens 49-52 18645209-3 2008 Pure phosphatidylcholine liposomes were persistent against apoA-I at pH levels above 5.0, but were progressively transformed into reconstituted HDLs (rHDLs) by apoA-I at lower pH. Phosphatidylcholines 5-24 apolipoprotein A1 Homo sapiens 59-65 18645209-3 2008 Pure phosphatidylcholine liposomes were persistent against apoA-I at pH levels above 5.0, but were progressively transformed into reconstituted HDLs (rHDLs) by apoA-I at lower pH. Phosphatidylcholines 5-24 apolipoprotein A1 Homo sapiens 160-166 19704440-3 2008 Lipid analyses on cold-acclimated freezing-treated ACBP6-overexpressors revealed a decline in phosphatidylcholine (PC) and an elevation of phosphatidic acid (PA) in comparison to wild type. Phosphatidylcholines 115-117 acyl-CoA-binding protein 6 Arabidopsis thaliana 51-56 19704440-4 2008 Furthermore, the His-tagged ACBP6 recombinant protein was observed using in vitro filter-binding assays to bind PC, but not PA or lysophosphatidylcholine. Phosphatidylcholines 112-114 acyl-CoA-binding protein 6 Arabidopsis thaliana 28-33 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 155-174 lysophosphatidylcholine acyltransferase 3 Homo sapiens 61-66 18789905-4 2008 A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 156-175 phosphatidylethanolamine N-methyltransferase Homo sapiens 189-233 18789905-4 2008 A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 156-175 phosphatidylethanolamine N-methyltransferase Homo sapiens 235-239 18821587-3 2008 G2A-deficient (G2A(-/-)) mice fed chow had a 25% reduction in biliary phosphatidylcholine content, reduced hepatic gene expression of the phosphatidylcholine transporter adenosine triphosphate-binding cassette B4, and an 8-fold increase in expression of the nuclear receptor liver X receptor (LXR). Phosphatidylcholines 70-89 G protein-coupled receptor 132 Mus musculus 0-3 18821587-3 2008 G2A-deficient (G2A(-/-)) mice fed chow had a 25% reduction in biliary phosphatidylcholine content, reduced hepatic gene expression of the phosphatidylcholine transporter adenosine triphosphate-binding cassette B4, and an 8-fold increase in expression of the nuclear receptor liver X receptor (LXR). Phosphatidylcholines 70-89 G protein-coupled receptor 132 Mus musculus 15-18 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 105-124 phospholipase A2 group X Homo sapiens 137-171 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 105-124 phospholipase A2 group X Homo sapiens 173-178 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 137-171 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 173-178 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 280-285 18587072-4 2008 Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. Phosphatidylcholines 78-84 phospholipase A2 group X Homo sapiens 8-13 18781607-10 2008 Bile from a mutation homozygote showed a reduced phosphatidylcholine/bile acid ratio, consistent with reduced ABCB4 phosphatidylcholine transport activity. Phosphatidylcholines 116-135 ATP binding cassette subfamily B member 4 Homo sapiens 110-115 18672068-5 2008 The orientation of Bax-C in membranes was also affected by negatively charged lipids, the presence of phosphatidylglycerol reduced the angle it forms with the normal to the germanium plate from 45 degrees in phosphatidylcholine to 27 degrees in phosphatidylglycerol vesicles. Phosphatidylcholines 208-227 BCL2 associated X, apoptosis regulator Homo sapiens 19-24 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 155-174 lysophosphatidylcholine acyltransferase 3 Homo sapiens 68-74 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 176-182 lysophosphatidylcholine acyltransferase 3 Homo sapiens 61-66 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 176-182 lysophosphatidylcholine acyltransferase 3 Homo sapiens 68-74 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 236-242 lysophosphatidylcholine acyltransferase 3 Homo sapiens 61-66 18781350-2 2008 Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho. Phosphatidylcholines 236-242 lysophosphatidylcholine acyltransferase 3 Homo sapiens 68-74 18667535-8 2008 Our analysis revealed that overexpression of Hmg2p caused significant and specific growth defects in nulls of the methylation pathway for phosphatidylcholine biosynthesis that includes the Psd1p enzyme. Phosphatidylcholines 138-157 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 45-50 18779284-7 2008 Phosphatidylcholine was modified by MTHFR genotype (P = 0.035; 677TT < 677CC). Phosphatidylcholines 0-19 methylenetetrahydrofolate reductase Homo sapiens 36-41 18667535-8 2008 Our analysis revealed that overexpression of Hmg2p caused significant and specific growth defects in nulls of the methylation pathway for phosphatidylcholine biosynthesis that includes the Psd1p enzyme. Phosphatidylcholines 138-157 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 189-194 18614529-1 2008 Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTalpha). Phosphatidylcholines 13-32 phosphate cytidylyltransferase 1A, choline Homo sapiens 129-137 18564386-7 2008 Expression in Escherichia coli revealed that NPC5 shows phospholipase C activity on phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 84-103 non-specific phospholipase C5 Arabidopsis thaliana 45-49 18614794-6 2008 The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin. Phosphatidylcholines 74-93 phosphatidylinositol transfer protein membrane associated 1 Homo sapiens 111-115 18614794-6 2008 The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin. Phosphatidylcholines 74-93 oxysterol binding protein Homo sapiens 158-162 18614794-6 2008 The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin. Phosphatidylcholines 74-93 ceramide transporter 1 Homo sapiens 167-171 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 6-25 cut-like homeobox 1 Rattus norvegicus 107-110 18523140-1 2008 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. Phosphatidylcholines 4-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 18949627-4 2008 It is shown that asyn increases the permeability to Mn(2+) of both large (200 nm diameter) and small (50 nm diameter) vesicles composed of zwitterionic phosphatidylcholine and anionic phosphatidylglycerol at protein/lipid molar ratios as low as 1:2000. Phosphatidylcholines 152-171 synuclein alpha Homo sapiens 17-21 18523140-1 2008 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. Phosphatidylcholines 4-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 18523140-1 2008 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. Phosphatidylcholines 4-23 phospholipase D2 Homo sapiens 60-64 18621979-8 2008 Lipid profiling analyses of rosettes from cold-acclimated, freezing-treated (-8 degrees C) transgenic Arabidopsis plants overexpressing ACBP6 showed a decline in phosphatidylcholine (-36% and -46%) and an elevation of phosphatidic acid (73% and 67%) in comparison with wild-type plants. Phosphatidylcholines 162-181 acyl-CoA-binding protein 6 Arabidopsis thaliana 136-141 18621979-9 2008 From our comparison, the gain in freezing tolerance in ACBP6 overexpressors that was accompanied by decreases in phosphatidylcholine and an accumulation of phosphatidic acid is consistent with previous findings on phospholipase Ddelta-overexpressing transgenic Arabidopsis. Phosphatidylcholines 113-132 acyl-CoA-binding protein 6 Arabidopsis thaliana 55-60 18621979-10 2008 In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine. Phosphatidylcholines 76-95 acyl-CoA-binding protein 6 Arabidopsis thaliana 64-69 18591246-3 2008 Here we show that down-regulation of SAH1 expression in yeast leads to accumulation of S-adenosyl-L-homocysteine and decreased de novo PC synthesis in vivo. Phosphatidylcholines 135-137 adenosylhomocysteinase Saccharomyces cerevisiae S288C 37-41 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines 114-116 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 36-40 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines 114-116 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 45-49 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines 134-136 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 36-40 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines 134-136 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 45-49 18667693-2 2008 We previously found that its synthesis from phosphatidylcholine is catalyzed by tonicity-regulated activity of the phospholipase B, neuropathy target esterase. Phosphatidylcholines 44-63 patatin like phospholipase domain containing 6 Homo sapiens 132-158 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 6-25 cut-like homeobox 1 Rattus norvegicus 164-167 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 27-29 cut-like homeobox 1 Rattus norvegicus 107-110 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 27-29 cut-like homeobox 1 Rattus norvegicus 164-167 18511424-2 2008 Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis. Phosphatidylcholines 35-54 phospholipase A2, group X Mus musculus 153-162 18782225-4 2008 In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans. Phosphatidylcholines 152-171 Lysophospholipid acyltransferase 5 Caenorhabditis elegans 98-104 18782225-4 2008 In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans. Phosphatidylcholines 173-175 Lysophospholipid acyltransferase 5 Caenorhabditis elegans 98-104 18511424-2 2008 Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis. Phosphatidylcholines 56-58 phospholipase A2, group X Mus musculus 153-162 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18723500-6 2008 Furthermore, we have determined that FASN inhibition results not only in lower phosphatidylcholine levels but also in a 59% drop in the phospholipid precursor phosphocholine (PCho). Phosphatidylcholines 79-98 fatty acid synthase Homo sapiens 37-41 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 92-111 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 17-47 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 92-111 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 49-54 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 92-111 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 76-80 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 113-115 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 17-47 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 113-115 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 49-54 18410282-1 2008 BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. Phosphatidylcholines 113-115 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 76-80 18410282-8 2008 CONCLUSIONS: Mdr2(-/-) mice maintain stable hepatic, serum and biliary PL metabolism in response to dietary PC manipulations. Phosphatidylcholines 108-110 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 13-17 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18398221-5 2008 Using electrospray ionization-mass spectrometry, primarily phosphatidylcholines and phosphatidylethanolamines were increased in iPLA(2)gamma-shRNA-treated cells. Phosphatidylcholines 59-79 patatin like phospholipase domain containing 8 Homo sapiens 128-140 18460912-4 2008 ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1. Phosphatidylcholines 45-64 ATP binding cassette subfamily A member 1 Homo sapiens 0-5 18506007-1 2008 BACKGROUND: Group X secretory phospholipase A(2) (sPLA(2)-X) has the most potent hydrolyzing activity toward phosphatidylcholine and elicits a marked release of arachidonic acid among several types of sPLA(2). Phosphatidylcholines 109-128 phospholipase A2, group X Mus musculus 50-59 18522808-8 2008 Compared to wildtype littermate controls, hearts from Gpat1(-/-)(-/-) mice contained a lower amount of 16:0 in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine/phosphatidylinositol and significantly more C20:4n6. Phosphatidylcholines 111-130 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 54-59 18522808-9 2008 Phosphatidylcholine and phosphatidylethanolamine from Gpat1(-/-)(-/-) hearts also contained higher amounts of 18:0 and 18:1. Phosphatidylcholines 0-19 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 54-59 18559668-2 2008 Here, we demonstrate that CCT alpha-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex. Phosphatidylcholines 45-64 phosphate cytidylyltransferase 1A, choline Homo sapiens 26-35 18460912-4 2008 ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1. Phosphatidylcholines 45-64 apolipoprotein A1 Homo sapiens 68-85 18460912-4 2008 ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1. Phosphatidylcholines 45-64 apolipoprotein A1 Homo sapiens 121-138 18164931-2 2008 A chitosan-egg phosphatidylcholine (chitosan-ePC) implant system containing PLA-b-PEG/PLA nanoparticles has been developed for the delivery of paclitaxel to treat ovarian cancer. Phosphatidylcholines 15-34 transcription factor 21 Mus musculus 45-48 18437350-4 2008 METHODS: Inhibition of ApoA-I glycation was assessed by incubating aminoguanidine, pyridoxamine, metformin and alagebrium with mixtures of methylglyoxal and discoidal reconstituted HDL (rHDL) containing phosphatidylcholine and ApoA-I, ([A-I]rHDL). Phosphatidylcholines 203-222 apolipoprotein A1 Homo sapiens 23-29 18472009-2 2008 When the content of cardiolipin (CL) in membranes at the expense of phosphatidylcholine matrix was increased, the ROS produced by recombinant human CYP2E1 was decreased as a function of CL concentration. Phosphatidylcholines 68-87 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 148-154 18343815-3 2008 PSS1 exchanges serine for choline of phosphatidylcholine, whereas PSS2 exchanges ethanolamine of phosphatidylethanolamine for serine. Phosphatidylcholines 37-56 phosphatidylserine synthase 1 Mus musculus 0-4 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18423385-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 18423385-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 18423385-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 18423385-1 2008 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidylcholines 40-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18064630-3 2008 We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN. Phosphatidylcholines 81-100 fibronectin 1 Homo sapiens 267-269 18064630-3 2008 We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN. Phosphatidylcholines 102-104 fibronectin 1 Homo sapiens 267-269 18064630-7 2008 We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM. Phosphatidylcholines 53-55 fibronectin 1 Homo sapiens 205-207 18064630-7 2008 We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM. Phosphatidylcholines 187-189 fibronectin 1 Homo sapiens 205-207 18335268-9 2008 Additionally, phosphatidylcholines (PCs) with an oxidized acyl chain at sn-2 position were found to be efficient as 1-palmitoyl LPC as substrates of lysoPLD. Phosphatidylcholines 14-34 ectonucleotide pyrophosphatase/phosphodiesterase 2 Bos taurus 149-156 18335268-9 2008 Additionally, phosphatidylcholines (PCs) with an oxidized acyl chain at sn-2 position were found to be efficient as 1-palmitoyl LPC as substrates of lysoPLD. Phosphatidylcholines 36-39 ectonucleotide pyrophosphatase/phosphodiesterase 2 Bos taurus 149-156 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidylcholines 40-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18276583-8 2008 The induction of CKI1 expression in zinc-depleted cells translated into increased choline kinase activity in vitro and in vivo, and an increase in phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 147-166 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 17-21 18451614-2 2008 Here, we used apoA-I and its model peptide, Ac-18A-NH(2), to investigate their interaction with mixed membranes of phosphatidylcholine (PC) with phosphatidylethanolamine (PE) or sphingomyelin (SM). Phosphatidylcholines 115-134 apolipoprotein A1 Homo sapiens 14-20 18451614-2 2008 Here, we used apoA-I and its model peptide, Ac-18A-NH(2), to investigate their interaction with mixed membranes of phosphatidylcholine (PC) with phosphatidylethanolamine (PE) or sphingomyelin (SM). Phosphatidylcholines 136-138 apolipoprotein A1 Homo sapiens 14-20 18398117-9 2008 Eosinophils, so prominent in asthmatic patients, synthesize the enzyme lysophospholipase, which, together with the enzyme phospholipase A(2), catalyzes the hydrolysis of the main component of the surfactant, phosphatidylcholine. Phosphatidylcholines 208-227 phospholipase A2 group IVA Homo sapiens 71-88 18276583-1 2008 In the yeast Saccharomyces cerevisiae, the CKI1-encoded choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine via the CDP-choline branch of the Kennedy pathway. Phosphatidylcholines 120-139 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 43-47 18166145-3 2008 Although both LL-37 and the mutant intercalated effectively into zwitterionic phosphatidylcholine membranes the presence of acidic phospholipids caused augmented membrane binding. Phosphatidylcholines 78-97 cathelicidin antimicrobial peptide Homo sapiens 14-19 18203956-0 2008 Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages. Phosphatidylcholines 0-19 C-C motif chemokine receptor 5 Homo sapiens 72-76 18203956-0 2008 Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 101-105 18203956-0 2008 Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages. Phosphatidylcholines 0-19 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 146-151 18203956-3 2008 In this study, we show for the first time that the phosphatidylcholine-specific phospholipase C (PC-PLC) is required for the production of CCL2 triggered by gp120 in human monocyte-derived macrophages (MDMs). Phosphatidylcholines 51-70 C-C motif chemokine ligand 2 Homo sapiens 139-143 18203956-3 2008 In this study, we show for the first time that the phosphatidylcholine-specific phospholipase C (PC-PLC) is required for the production of CCL2 triggered by gp120 in human monocyte-derived macrophages (MDMs). Phosphatidylcholines 51-70 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 157-162 18081857-4 2008 OBJECTIVE: To evaluate the capability of phosphatidylcholine + deoxycholate + ethanol (PPC/DC/E) to reduce body fat with a half-side pilot study for the reduction of saddlebag trochanteric bulges. Phosphatidylcholines 41-60 phosphopantothenoylcysteine decarboxylase Homo sapiens 87-95 18336573-7 2008 The iPLA(2)-VIA effects were found to be independent of the generation of free arachidonic acid or one of its oxygenated metabolites, and may work through regulation of the cellular level of phosphatidylcholine, a structural lipid that is required for cell growth/membrane expansion. Phosphatidylcholines 191-210 phospholipase A2 group VI Homo sapiens 4-15 17985365-0 2008 Nonpolar interactions between trans-membrane helical EGF peptide and phosphatidylcholines, sphingomyelins and cholesterol. Phosphatidylcholines 69-89 epidermal growth factor Homo sapiens 53-56 18287365-3 2008 The objective of this study was to determine whether homocysteine lowering with a B vitamin supplement affects the proportion of (n-3) long-chain PUFA in plasma phosphatidylcholine. Phosphatidylcholines 161-180 pumilio RNA binding family member 3 Homo sapiens 146-150 18165686-4 2008 Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL. Phosphatidylcholines 135-154 phospholipase A2 group VII Homo sapiens 108-117 18165686-4 2008 Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL. Phosphatidylcholines 156-158 phospholipase A2 group VII Homo sapiens 108-117 17993484-5 2008 The binding of peptides to membranes was confirmed by surface pressure (Langmuir film balance) measurements using phosphatidylcholine/phosphatidylserine monolayers, which show a significant increase after injection of rat annexin A1 N-terminal peptides. Phosphatidylcholines 114-133 annexin A1 Rattus norvegicus 222-232 17588738-9 2008 The response of phosphatidylcholine to folate intake appeared to be influenced by MTHFR C677T genotype. Phosphatidylcholines 16-35 methylenetetrahydrofolate reductase Homo sapiens 82-87 18180163-2 2008 Membrane-permeabilizing activities of AM2, AM3, and AM6 were examined using fluorescent-dye leakage experiments with various phosphatidylcholines (PCs) and sterols. Phosphatidylcholines 125-145 adrenomedullin 2 Homo sapiens 38-41 18180163-2 2008 Membrane-permeabilizing activities of AM2, AM3, and AM6 were examined using fluorescent-dye leakage experiments with various phosphatidylcholines (PCs) and sterols. Phosphatidylcholines 147-150 adrenomedullin 2 Homo sapiens 38-41 18180163-5 2008 In liposomes consisting of unsaturated PC, AM2, which possesses an additional ether ring in a polyhydroxyl chain, showed membrane-permeabilizing activities with a moderate efficacy, while AM3 or AM6 did not. Phosphatidylcholines 39-41 adrenomedullin 2 Homo sapiens 43-46 18036176-2 2008 PLD1 hydrolyzes phosphatidylcholine to produce phosphatidic acid (PA) and a free choline headgroup. Phosphatidylcholines 16-35 phospholipase D Saccharomyces cerevisiae S288C 0-4 17624579-0 2008 Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. Phosphatidylcholines 54-73 solute carrier family 6 member 8 Rattus norvegicus 95-114 18242748-1 2008 The hepatic transporter Mdr2 is an ATP-binding cassette transporter which excretes phosphatidylcholine into the bile. Phosphatidylcholines 83-102 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 24-28 18055762-2 2008 Infrared difference spectra show that concentrations of tetracaine consistent with binding to the ion channel (<50 microM) stabilize a resting-like state when the nAChR is reconstituted into phosphatidylcholine membranes containing the anionic lipid, phosphatidic acid, but have no effect on the nAChR reconstituted into membranes lacking phosphatidic acid, either in the presence or absence of cholesterol. Phosphatidylcholines 194-213 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 166-171 18036206-7 2008 In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine. Phosphatidylcholines 170-189 sinapine esterase Brassica napus 15-32 18036206-7 2008 In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine. Phosphatidylcholines 170-189 sinapine esterase Brassica napus 72-78 18036206-7 2008 In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine. Phosphatidylcholines 170-189 sinapine esterase Brassica napus 79-85 17951297-3 2008 Substitution of 20-60% phosphatidylethanolamine (DOPE) for phosphatidylcholine in the v-SNARE vesicle with either 0 or 20% DOPE included in the t-SNARE bilayer gives rise to hemifusion events. Phosphatidylcholines 59-78 vesicle transport through interaction with t-SNAREs 1B Homo sapiens 86-93 17951297-3 2008 Substitution of 20-60% phosphatidylethanolamine (DOPE) for phosphatidylcholine in the v-SNARE vesicle with either 0 or 20% DOPE included in the t-SNARE bilayer gives rise to hemifusion events. Phosphatidylcholines 59-78 small NF90 (ILF3) associated RNA E Homo sapiens 88-93 17982138-1 2008 Sphingomyelin synthase (SMS), the last enzyme in the sphingomyelin (SM) biosynthetic pathway, uses ceramide and phosphatidylcholine as substrates to produce SM and diacylglycerol (DAG). Phosphatidylcholines 112-131 spermine synthase Homo sapiens 0-22 17982138-1 2008 Sphingomyelin synthase (SMS), the last enzyme in the sphingomyelin (SM) biosynthetic pathway, uses ceramide and phosphatidylcholine as substrates to produce SM and diacylglycerol (DAG). Phosphatidylcholines 112-131 spermine synthase Homo sapiens 24-27 18243114-1 2008 Sec14, the major yeast phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein, regulates essential interfaces between lipid metabolism and membrane trafficking from the trans-Golgi network (TGN). Phosphatidylcholines 53-72 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 17662254-5 2008 The "newly formed" phosphatidylcholine is felt to induce alterations in the membrane fluidity, which might favor vesicular fusion with the plasma membrane for the exocytosis of insulin. Phosphatidylcholines 19-38 insulin Homo sapiens 177-184 18042552-1 2008 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 125-144 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 18042552-1 2008 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 125-144 cut-like homeobox 1 Mus musculus 81-84 18042552-1 2008 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 146-148 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 18042552-1 2008 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 146-148 cut-like homeobox 1 Mus musculus 81-84 18042552-8 2008 When knock-out hepatocytes were infected with an adenovirus expressing CTalpha, apoAI-dependent PC efflux returned partially, whereas cholesterol efflux and ABCA1 levels were not restored to normal levels. Phosphatidylcholines 96-98 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 71-78 18042552-11 2008 The observations demonstrate that hepatic PC biosynthesis is a key player in maintaining plasma VLDL and HDL, and further underscores the importance of the liver in HDL formation. Phosphatidylcholines 42-44 CD320 antigen Mus musculus 96-100 18029352-0 2008 Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 105-124 choline kinase alpha Mus musculus 63-83 18029352-1 2008 Choline kinase alpha (CK-alpha) is one of two mammalian enzymes that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid, phosphatidylcholine. Phosphatidylcholines 183-202 choline kinase alpha Homo sapiens 0-30 18029352-9 2008 Thus, Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine. Phosphatidylcholines 144-163 choline kinase alpha Mus musculus 6-10 18003621-0 2008 Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. Phosphatidylcholines 42-61 acyl-CoA synthetase long chain family member 3 Homo sapiens 0-32 18003621-4 2008 In cultured human hepatoma Huh7 cells, ACSL3 is specifically required for incorporation of fatty acids into phosphatidylcholine. Phosphatidylcholines 108-127 acyl-CoA synthetase long chain family member 3 Homo sapiens 39-44 17981627-7 2008 TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes. Phosphatidylcholines 122-141 tumor necrosis factor Homo sapiens 0-9 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 46-66 phospholipase A2 group X Homo sapiens 0-26 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 46-66 phospholipase A2 group X Homo sapiens 28-33 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 68-70 phospholipase A2 group X Homo sapiens 0-26 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 68-70 phospholipase A2 group X Homo sapiens 28-33 18156367-9 2008 Characterization of the product of the Aytl2 gene as the phosphatidylcholine reacylating enzyme in RBCs represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein. Phosphatidylcholines 57-76 lysophosphatidylcholine acyltransferase 1 Homo sapiens 39-44 18061140-6 2008 In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC). Phosphatidylcholines 222-241 transthyretin Homo sapiens 38-41 18061140-6 2008 In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC). Phosphatidylcholines 243-245 transthyretin Homo sapiens 38-41 17981627-7 2008 TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes. Phosphatidylcholines 122-141 interleukin 1 alpha Homo sapiens 14-23 17981627-8 2008 Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling. Phosphatidylcholines 50-69 tumor necrosis factor Homo sapiens 138-147 17981627-8 2008 Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling. Phosphatidylcholines 50-69 interleukin 1 alpha Homo sapiens 151-160 18826063-2 2008 The polar choline head groups on immobilized phosphatidylcholine were used for the affinity purification of phospholipase A (PLA). Phosphatidylcholines 45-64 phospholipase A and acyltransferase 1 Homo sapiens 108-123 17890138-4 2008 Our results showed that suppressing phosphatidylcholine-specific phospholipase C in the presence of basic fibroblast growth factor could induce cell neuronal differentiation and the viability of the differentiated cells was obviously increased. Phosphatidylcholines 36-55 fibroblast growth factor 2 Rattus norvegicus 100-130 18826063-2 2008 The polar choline head groups on immobilized phosphatidylcholine were used for the affinity purification of phospholipase A (PLA). Phosphatidylcholines 45-64 phospholipase A and acyltransferase 1 Homo sapiens 125-128 18052211-5 2007 In a mixed 70% phosphatidylcholine/30% dilaurin environment, colipase adsorbs to but does not penetrate deeply into the film. Phosphatidylcholines 15-34 colipase Homo sapiens 61-69 17627030-2 2007 Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types. Phosphatidylcholines 64-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-108 18221610-1 2007 ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 42-61 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 18221610-1 2007 ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 42-61 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 17726488-2 2007 ABCB4 is the liver-specific membrane transporter of phosphatidylcholine, a major and exclusive component of mammalian bile. Phosphatidylcholines 52-71 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17890067-4 2007 SIF containing 5mM sodium taurocholate and 1.25 mM phosphatidylcholine or lysophosphatidylcholine in Leibovitz"s L-15 induced less release of lactate dehydrogenase than the traditional transport medium, HBSS. Phosphatidylcholines 51-70 immunoglobulin kappa variable 1D-16 Homo sapiens 113-117 17627030-2 2007 Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types. Phosphatidylcholines 64-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 110-113 17996202-0 2007 The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. Phosphatidylcholines 82-101 lysophospholipid acyltransferase Saccharomyces cerevisiae S288C 39-43 18032786-0 2007 The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. Phosphatidylcholines 32-52 tumor protein p53 Homo sapiens 127-130 18032786-0 2007 The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. Phosphatidylcholines 32-52 ATR serine/threonine kinase Homo sapiens 153-156 18032786-7 2007 Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2). Phosphatidylcholines 66-86 phospholipase A2 group VI Homo sapiens 226-233 18032786-7 2007 Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2). Phosphatidylcholines 88-91 phospholipase A2 group VI Homo sapiens 226-233 18032786-7 2007 Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2). Phosphatidylcholines 160-163 phospholipase A2 group VI Homo sapiens 226-233 16996649-5 2007 The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues. Phosphatidylcholines 113-132 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-20 16996649-5 2007 The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues. Phosphatidylcholines 134-136 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-20 18032786-10 2007 Our findings establish that cells can regulate the levels of polyunsaturated fatty acids in phospholipids through iPLA(2)-mediated deacylation of PCs. Phosphatidylcholines 146-149 phospholipase A2 group VI Homo sapiens 114-121 18032786-11 2007 Disruption of this regulation increases the proportions of PCs containing polyunsaturated fatty acids and activates the ATR-p53 signalling pathway. Phosphatidylcholines 59-62 ATR serine/threonine kinase Homo sapiens 120-123 18032786-11 2007 Disruption of this regulation increases the proportions of PCs containing polyunsaturated fatty acids and activates the ATR-p53 signalling pathway. Phosphatidylcholines 59-62 tumor protein p53 Homo sapiens 124-127 17996202-4 2007 We further show that disruption of LCA1 caused an enhanced production of glycerophosphorylcholine, a product of phosphatidylcholine (PC) deacylation and that the lysophosphatidic acid acyltransferase SLC1 was not involved in this process. Phosphatidylcholines 112-131 lysophospholipid acyltransferase Saccharomyces cerevisiae S288C 35-39 17996202-4 2007 We further show that disruption of LCA1 caused an enhanced production of glycerophosphorylcholine, a product of phosphatidylcholine (PC) deacylation and that the lysophosphatidic acid acyltransferase SLC1 was not involved in this process. Phosphatidylcholines 133-135 lysophospholipid acyltransferase Saccharomyces cerevisiae S288C 35-39 17974980-10 2007 Wild-type and bax(-/-)bak(-/-) cells showed similar patterns of phosphatidylcholine and protein synthesis inhibition, despite their differences in drug sensitivity. Phosphatidylcholines 64-83 BCL2 associated X, apoptosis regulator Homo sapiens 14-17 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 290-309 phospholipase A2 group IIA Homo sapiens 16-43 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 290-309 phospholipase A2 group IIA Homo sapiens 45-52 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 290-309 phospholipase A2 group IID Homo sapiens 96-104 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 290-309 phospholipase A2 group IID Homo sapiens 150-158 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 311-313 phospholipase A2 group IIA Homo sapiens 16-43 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 311-313 phospholipase A2 group IIA Homo sapiens 45-52 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 311-313 phospholipase A2 group IID Homo sapiens 96-104 17980167-2 2007 Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane. Phosphatidylcholines 311-313 phospholipase A2 group IID Homo sapiens 150-158 17804406-1 2007 CTP:phosphocholine cytidylyltransferase (CCTalpha) is a proteolytically sensitive enzyme essential for production of phosphatidylcholine, the major phospholipid of animal cell membranes. Phosphatidylcholines 117-136 phosphate cytidylyltransferase 1A, choline Homo sapiens 41-49 17974980-10 2007 Wild-type and bax(-/-)bak(-/-) cells showed similar patterns of phosphatidylcholine and protein synthesis inhibition, despite their differences in drug sensitivity. Phosphatidylcholines 64-83 BCL2 antagonist/killer 1 Homo sapiens 22-25 17994285-4 2007 Elevation of the lung surfactant phosphatidylcholine (PC) has previously been reported in the Hexb mouse, a model of Sandhoff disease. Phosphatidylcholines 33-52 hexosaminidase B Mus musculus 94-98 17656736-10 2007 Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles. Phosphatidylcholines 37-56 apolipoprotein A1 Homo sapiens 153-159 17656736-10 2007 Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles. Phosphatidylcholines 37-56 apolipoprotein A1 Homo sapiens 173-179 17656736-10 2007 Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles. Phosphatidylcholines 37-56 apolipoprotein A1 Homo sapiens 173-179 17761632-2 2007 We have shown that ABCG1 mediates the efflux of not only cholesterol but also sphingomyelin (SM) and phosphatidylcholine. Phosphatidylcholines 101-120 ATP-binding cassette sub-family G member 1 Cricetulus griseus 19-24 17994285-4 2007 Elevation of the lung surfactant phosphatidylcholine (PC) has previously been reported in the Hexb mouse, a model of Sandhoff disease. Phosphatidylcholines 54-56 hexosaminidase B Mus musculus 94-98 18053412-4 2007 One clone displaying the peptide SVSVGMKPSPRP (designated as PS3-10) bound to PS approximately 4-fold better than its binding to phosphatidylcholine and 18-fold better than to bovine serum albumin in a solid-phase binding assay. Phosphatidylcholines 129-148 taste 2 receptor member 6 pseudogene Homo sapiens 61-64 17497080-2 2007 To study the influence of cholesterol on P-gp in a well defined lipid environment, we reconstituted P-gp in egg phosphatidylcholine (PhC) and PhC/cholesterol proteoliposomes with negligible residual amounts of detergents. Phosphatidylcholines 133-136 ATP binding cassette subfamily B member 1 Homo sapiens 100-104 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17899539-0 2007 Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells. Phosphatidylcholines 19-38 Fc gamma receptor IIIa Homo sapiens 78-82 17917852-1 2007 CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Phosphatidylcholines 43-62 cut-like homeobox 1 Rattus norvegicus 0-3 17601877-2 2007 Inactivation of the CDP-choline pathway for phosphatidylcholine synthesis allows cells to survive in the absence of Sec14p function through restoration of Golgi vesicular transport capability. Phosphatidylcholines 44-63 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 116-122 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 72-91 Spo20p Saccharomyces cerevisiae S288C 16-22 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 72-91 phospholipase D Saccharomyces cerevisiae S288C 53-59 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 93-95 Spo20p Saccharomyces cerevisiae S288C 16-22 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 93-95 phospholipase D Saccharomyces cerevisiae S288C 53-59 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 138-140 Spo20p Saccharomyces cerevisiae S288C 16-22 17714435-4 2007 The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA). Phosphatidylcholines 138-140 phospholipase D Saccharomyces cerevisiae S288C 53-59 17704541-4 2007 PC-TP, which binds phosphatidylcholine exclusively, is expressed during embryonic development and in several tissues of the adult mouse, including liver. Phosphatidylcholines 19-38 phosphatidylcholine transfer protein Mus musculus 0-5 17704541-12 2007 These findings suggest that PC-TP functions as a phosphatidylcholine-sensing molecule that engages in diverse regulatory activities that depend upon the cellular expression of distinct interacting proteins. Phosphatidylcholines 49-68 phosphatidylcholine transfer protein Mus musculus 28-33 17701359-8 2007 We demonstrated also that myeloperoxidase is eluted together with pure phosphatidylserine liposomes or liposomes composed of phosphatidylserine and phosphatidylcholine in gel filtration, but not with pure phosphatidylcholine liposomes. Phosphatidylcholines 148-167 myeloperoxidase Homo sapiens 26-41 17899539-2 2007 Our recent findings indicate that CD16 expression on the outer membrane surface of NK cells is correlated with the membrane expression of phosphatidylcholine-specific phospholipase C (PC-PLC). Phosphatidylcholines 138-157 Fc gamma receptor IIIa Homo sapiens 34-38 17722906-4 2007 POR-null mice had drastic increases in hepatic lipid content (diacylglycerols, triacylglycerols, phosphatidylcholine, and cholesterol esters) and a specific enrichment in n-7 and n-9 monounsaturated fatty acids (FAs). Phosphatidylcholines 97-116 cytochrome p450 oxidoreductase Mus musculus 0-3 17626977-1 2007 A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. Phosphatidylcholines 98-117 phospholipase A2 group XV Homo sapiens 8-36 17626977-1 2007 A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. Phosphatidylcholines 98-117 phospholipase A2 group XV Homo sapiens 38-43 17895836-5 2007 The enzyme presented a penetration power value into an egg phosphatidylcholine monomolecular film that was comparable to that of HPL and lower than that of TPL. Phosphatidylcholines 59-78 pancreatic triacylglycerol lipase Meleagris gallopavo 156-159 17852852-1 2007 OBJECTIVE: Abcb4 (-/-) mice secrete phosphatidylcholine-free, cytotoxic bile and develop chronic cholangitis. Phosphatidylcholines 36-55 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 11-16 17881569-1 2007 The Saccharomyces cerevisiae phosphatidylcholine/phosphatidylinositol transfer protein Sec14p is required for Golgi apparatus-derived vesicular transport through coordinate regulation of phospholipid metabolism. Phosphatidylcholines 29-48 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 87-93 17881569-3 2007 The essential requirement for SEC14 can be bypassed by inactivation of (i) the CDP-choline pathway for phosphatidylcholine synthesis or (ii) KES1, which encodes an oxysterol binding protein. Phosphatidylcholines 103-122 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 30-35 17616479-10 2007 We measured cellular lipid levels, including SM, ceramide, phosphatidylcholine, and diacylglycerol and found that SMS1 and SMS2 siRNA treatment caused a significant decrease of SM levels (20% and 11%, respectively), compared to control siRNA treatment; SMS1 but not SMS2 siRNA treatment caused a significant increase of ceramide levels (10%). Phosphatidylcholines 59-78 sphingomyelin synthase 1 Homo sapiens 114-118 18050888-2 2007 Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Phosphatidylcholines 97-116 patatin-like phospholipase domain containing 6 Mus musculus 0-26 18050888-2 2007 Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Phosphatidylcholines 97-116 patatin-like phospholipase domain containing 6 Mus musculus 28-31 18050888-2 2007 Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Phosphatidylcholines 118-124 patatin-like phospholipase domain containing 6 Mus musculus 0-26 18050888-2 2007 Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Phosphatidylcholines 118-124 patatin-like phospholipase domain containing 6 Mus musculus 28-31 17616479-10 2007 We measured cellular lipid levels, including SM, ceramide, phosphatidylcholine, and diacylglycerol and found that SMS1 and SMS2 siRNA treatment caused a significant decrease of SM levels (20% and 11%, respectively), compared to control siRNA treatment; SMS1 but not SMS2 siRNA treatment caused a significant increase of ceramide levels (10%). Phosphatidylcholines 59-78 sphingomyelin synthase 2 Homo sapiens 123-127 17827718-9 2007 In addition, PAF-AH selectively hydrolyzed oxidatively modified phosphatidylcholine. Phosphatidylcholines 64-83 phospholipase A2 group VII Homo sapiens 13-19 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 273-275 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 16-55 18050660-0 2007 [Depth-dependent investigation of the apolar zone of lipid membranes using a series of fluorescent probes, Me4-BODIPY-8-labeled phosphatidylcholines]. Phosphatidylcholines 128-148 protocadherin beta 17 pseudogene Homo sapiens 107-110 18050660-1 2007 A series of lipid probes, phosphatidylcholines labeled with Me4-BODIPY-8 (4,4-difluoro-1,3,5,7- tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl) fluorophore attached to the end of an acyl residue at different distances from the polar head, were used as depth-dependent probes for the apolar zone of model membrane systems, large unilamellar vesicles (LUVs). Phosphatidylcholines 26-46 protocadherin beta 17 pseudogene Homo sapiens 60-63 17608770-4 2007 MDR2, the amino acid sequence of which has 86% similarity to that of MDR1, excretes phosphatidylcholine and cholesterol in the presence of bile salts. Phosphatidylcholines 84-103 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 17608770-4 2007 MDR2, the amino acid sequence of which has 86% similarity to that of MDR1, excretes phosphatidylcholine and cholesterol in the presence of bile salts. Phosphatidylcholines 84-103 ATP binding cassette subfamily B member 1 Homo sapiens 69-73 17608770-5 2007 ABCA1 transfers phospholipids, preferentially phosphatidylcholine, and cholesterol to lipid-free apoA-I to generate pre-beta-HDL, and ABCG1 excretes phospholipids, preferentially sphingomyelin, and cholesterol. Phosphatidylcholines 46-65 ATP binding cassette subfamily A member 1 Homo sapiens 0-5 17683117-0 2007 PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding. Phosphatidylcholines 103-122 programmed cell death 1 ligand 2 Mus musculus 0-5 17729124-1 2007 A new potentially antioxidant compound, spin-labelled lutein (SL-lut), was synthesized and incorporated into egg yolk phosphatidylcholine (EYPC) liposome membrane. Phosphatidylcholines 118-137 spindlin 1 Homo sapiens 40-44 17595447-1 2007 The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. Phosphatidylcholines 67-86 phosphatidylethanolamine N-methyltransferase Mus musculus 4-48 17595447-1 2007 The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. Phosphatidylcholines 67-86 phosphatidylethanolamine N-methyltransferase Mus musculus 50-54 17595447-1 2007 The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. Phosphatidylcholines 88-90 phosphatidylethanolamine N-methyltransferase Mus musculus 4-48 17595447-1 2007 The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. Phosphatidylcholines 88-90 phosphatidylethanolamine N-methyltransferase Mus musculus 50-54 17595447-2 2007 We evaluated whether the PEMT pathway is quantitatively important for biliary PC secretion in mice under various experimental conditions. Phosphatidylcholines 78-80 phosphatidylethanolamine N-methyltransferase Mus musculus 25-29 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 85-87 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 16-55 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 85-87 cut-like homeobox 1 Mus musculus 109-112 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 85-87 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 151-181 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 273-275 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 151-181 17595447-4 2007 The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Phosphatidylcholines 273-275 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 183-187 17561512-1 2007 StarD10 is a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes in vitro. Phosphatidylcholines 74-93 StAR related lipid transfer domain containing 10 Homo sapiens 0-7 17513168-5 2007 Plasma PC levels in high-density lipoproteins (HDLs) were higher in male Pemt(-/-) mice than those in females before choline deprivation. Phosphatidylcholines 7-9 phosphatidylethanolamine N-methyltransferase Mus musculus 73-77 17570332-2 2007 In the presence of 30% cholesterol in a noncharged phosphatidylcholine (PC) phospholipid membrane, KA1 (binding affinity constant) and KA2 (insertion affinity constant) derived from a two-step model decreased significantly. Phosphatidylcholines 51-70 glutamate ionotropic receptor kainate type subunit 4 Homo sapiens 99-102 17570332-2 2007 In the presence of 30% cholesterol in a noncharged phosphatidylcholine (PC) phospholipid membrane, KA1 (binding affinity constant) and KA2 (insertion affinity constant) derived from a two-step model decreased significantly. Phosphatidylcholines 51-70 glutamate ionotropic receptor kainate type subunit 5 Homo sapiens 135-138 17472963-6 2007 The mutational effect was specific for C1P as all of the cationic mutants of cPLA(2)alpha demonstrated normal basal activity as well as normal affinities for phosphatidylcholine and phosphatidylinositol-4,5-bisphosphate as compared with wild-type cPLA(2)alpha. Phosphatidylcholines 158-177 phospholipase A2 group IVA Homo sapiens 77-89 17591919-2 2007 Recruitment and activation of PKD at the TGN is mediated by the lipid diacylglycerol, a pool of which is generated by sphingomyelin synthase from ceramide and phosphatidylcholine. Phosphatidylcholines 159-178 protein kinase D1 Homo sapiens 30-33 17614848-1 2007 Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 161-205 17614848-1 2007 Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 207-211 17614848-7 2007 The observed increase in PEMT-specific activity in the residual intestine suggests that extensive enterectomy stimulates the synthesis of phosphatidylcholine by the PEMT-controlled pathway. Phosphatidylcholines 138-157 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 25-29 17614848-7 2007 The observed increase in PEMT-specific activity in the residual intestine suggests that extensive enterectomy stimulates the synthesis of phosphatidylcholine by the PEMT-controlled pathway. Phosphatidylcholines 138-157 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 165-169 17381426-13 2007 AKR1A4, B1, B7 and B8 catalysed the reduction of aldehydes generated in oxidized C(16:0-20:4) phosphatidylcholine with acyl, plasmenyl or alkyl linkage at the sn-1 position or C(16:0-20:4) phosphatidylglycerol or phosphatidic acid. Phosphatidylcholines 94-113 aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus 0-6 17381426-13 2007 AKR1A4, B1, B7 and B8 catalysed the reduction of aldehydes generated in oxidized C(16:0-20:4) phosphatidylcholine with acyl, plasmenyl or alkyl linkage at the sn-1 position or C(16:0-20:4) phosphatidylglycerol or phosphatidic acid. Phosphatidylcholines 94-113 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 8-21 17531529-2 2007 Although both cell models differed significantly in their cellular lipid composition, a higher apoA-I specific efflux was found for monounsaturated phosphatidylcholine (PC) species together with a decreased contribution of polyunsaturated PC species in both cell types. Phosphatidylcholines 169-171 apolipoprotein A1 Homo sapiens 95-101 17499576-3 2007 In this study the membrane properties of sphingomyelin and phosphatidylcholine containing elaidic acid (N-E-SM and PEPC) were determined in bilayer membranes with special emphasis on their interaction with cholesterol and participation in ordered domain formation. Phosphatidylcholines 59-78 peptidase C Homo sapiens 115-119 17531529-7 2007 In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I. Phosphatidylcholines 137-139 apolipoprotein A1 Homo sapiens 24-30 17531529-7 2007 In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I. Phosphatidylcholines 137-139 ATP binding cassette subfamily A member 1 Homo sapiens 31-36 17482853-2 2007 We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis. Phosphatidylcholines 236-238 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 187-190 17531529-7 2007 In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I. Phosphatidylcholines 137-139 HDL3 Homo sapiens 41-47 17531529-7 2007 In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I. Phosphatidylcholines 137-139 apolipoprotein A1 Homo sapiens 164-170 17482853-2 2007 We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis. Phosphatidylcholines 236-238 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 146-185 17482853-5 2007 Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology. Phosphatidylcholines 53-55 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 85-93 17482853-5 2007 Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology. Phosphatidylcholines 53-55 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 139-147 17520483-1 2007 Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules. Phosphatidylcholines 158-160 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 0-4 17523162-11 2007 Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin. Phosphatidylcholines 106-108 EPH receptor A3 Homo sapiens 66-69 17523162-11 2007 Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin. Phosphatidylcholines 106-108 ATP binding cassette subfamily B member 4 Homo sapiens 70-75 17613109-1 2007 Cytidine-5"-diphosphocholine (citicoline or CDP-choline) is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine. Phosphatidylcholines 120-139 cut-like homeobox 1 Mus musculus 44-47 17520483-0 2007 Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae. Phosphatidylcholines 0-19 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 80-114 17520483-0 2007 Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae. Phosphatidylcholines 0-19 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 115-119 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 40-59 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 61-63 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 108-110 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17520483-1 2007 Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules. Phosphatidylcholines 137-156 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 0-4 17520483-1 2007 Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules. Phosphatidylcholines 158-160 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 24-58 17520483-1 2007 Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules. Phosphatidylcholines 137-156 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 24-58 17520483-2 2007 In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered. Phosphatidylcholines 73-75 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 41-45 17520483-2 2007 In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered. Phosphatidylcholines 106-108 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 41-45 17520483-2 2007 In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered. Phosphatidylcholines 106-108 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 41-45 17520483-3 2007 PC depletion was found to reduce growth on glycerol and to increase glycerol excretion, both indicating that PC is needed for optimal Gut2 functioning in vivo. Phosphatidylcholines 0-2 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 134-138 17520483-3 2007 PC depletion was found to reduce growth on glycerol and to increase glycerol excretion, both indicating that PC is needed for optimal Gut2 functioning in vivo. Phosphatidylcholines 109-111 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 134-138 17520483-4 2007 Using several in vitro approaches the nature of the dependence of Gut2 functioning on cellular PC contents was investigated. Phosphatidylcholines 95-97 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 66-70 17520483-6 2007 The in vivo effects are more likely an indirect result of PC depletion-induced changes in the cellular context in which Gut2 functions, that are not manifested in the in vitro systems used. Phosphatidylcholines 58-60 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 120-124 17490911-3 2007 Mammalian phosphatidylinositol transfer proteins, PITPalpha and PITPbeta are paralogs that share 77% sequence identity and contain a hydrophobic cavity that can sequester either phosphatidylinositol or phosphatidylcholine. Phosphatidylcholines 202-221 phosphatidylinositol transfer protein alpha Homo sapiens 50-59 17490911-3 2007 Mammalian phosphatidylinositol transfer proteins, PITPalpha and PITPbeta are paralogs that share 77% sequence identity and contain a hydrophobic cavity that can sequester either phosphatidylinositol or phosphatidylcholine. Phosphatidylcholines 202-221 phosphatidylinositol transfer protein beta Homo sapiens 64-72 17499021-1 2007 Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. Phosphatidylcholines 111-130 phosphatidylcholine transfer protein Mus musculus 0-36 17462583-12 2007 These results are in agreement with previously reported DSC and (2)H NMR spectroscopy study of the interaction of the L(24) and structurally related peptides with phosphatidylcholine bilayers. Phosphatidylcholines 163-182 immunoglobulin kappa variable 1D-8 Homo sapiens 118-123 17499021-1 2007 Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. Phosphatidylcholines 111-130 phosphatidylcholine transfer protein Mus musculus 38-43 17499021-4 2007 Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypothesis that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism. Phosphatidylcholines 281-300 phosphatidylcholine transfer protein Mus musculus 50-54 17613168-3 2007 A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 156-175 phosphatidylethanolamine N-methyltransferase Homo sapiens 189-233 17613168-3 2007 A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver. Phosphatidylcholines 156-175 phosphatidylethanolamine N-methyltransferase Homo sapiens 235-239 17325006-1 2007 Sec14p promotes the energy-independent transfer of either phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between lipid bilayers in vitro and represents the major PtdIns/PtdCho transfer protein in the budding yeast Saccharomyces cerevisiae. Phosphatidylcholines 91-110 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-6 17430887-6 2007 We measured the binding of catalytically competent mouse PLC-zeta to phospholipid vesicles: for 2:1 phosphatidylcholine/phosphatidylserine (PC/PS) vesicles, the molar partition coefficient, K, is too weak to be of physiological significance. Phosphatidylcholines 100-119 phospholipase C, zeta 1 Mus musculus 57-65 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidylcholines 135-154 phosphatase and tensin homolog Homo sapiens 10-14 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 190-205 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 207-210 17409096-8 2007 These results suggest that the function of ABCA1 could be divided into two steps: (i) a flopping step to move phosphatidylcholine and cholesterol from the inner to outer leaflet of the plasma membrane, where cholesterol becomes available to cold MbetaCD extraction, and (ii) a loading step to load phosphatidylcholine and cholesterol onto apoA-I to generate HDL. Phosphatidylcholines 110-129 phospholipid-transporting ATPase ABCA1 Cricetulus griseus 43-48 17409096-8 2007 These results suggest that the function of ABCA1 could be divided into two steps: (i) a flopping step to move phosphatidylcholine and cholesterol from the inner to outer leaflet of the plasma membrane, where cholesterol becomes available to cold MbetaCD extraction, and (ii) a loading step to load phosphatidylcholine and cholesterol onto apoA-I to generate HDL. Phosphatidylcholines 298-317 phospholipid-transporting ATPase ABCA1 Cricetulus griseus 43-48 17325006-2 2007 Herein, we employ multi-frequency high-field electron paramagnetic resonance (EPR) to analyze the electrostatic and hydrogen-bonding microenvironments for series of doxyl-labeled PtdCho molecules bound by Sec14p in a soluble protein-PtdCho complex. Phosphatidylcholines 179-185 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 205-211 17325006-6 2007 Partially resolved 130-GHz EPR spectra from n-doxyl-PtdCho bound to Sec14p were analyzed using this two-component model and allowed quantification of two parameters. Phosphatidylcholines 52-58 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 68-74 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 17218027-1 2007 We previously reported that vasoactive intestinal peptide (VIP) promoted synthesis of phosphatidylcholine (PC) in alveolar type II (ATII) cells. Phosphatidylcholines 86-105 vasoactive intestinal peptide Homo sapiens 59-62 17218027-1 2007 We previously reported that vasoactive intestinal peptide (VIP) promoted synthesis of phosphatidylcholine (PC) in alveolar type II (ATII) cells. Phosphatidylcholines 107-109 vasoactive intestinal peptide Homo sapiens 59-62 17218027-3 2007 In this work, we investigated the intracellular signal transduction pathway for VIP promoted synthesis of PC, the major lipid component of pulmonary surfactant (PS), by using an antagonist of VIP receptors, inhibitor of protein kinase C (PKC) and antisense oligonucleotides (AS-ODN) for c-fos oncogene. Phosphatidylcholines 106-108 vasoactive intestinal peptide Homo sapiens 80-83 17218027-6 2007 These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC. Phosphatidylcholines 161-163 vasoactive intestinal peptide Homo sapiens 32-35 17218027-6 2007 These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC. Phosphatidylcholines 161-163 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 55-60 17218027-6 2007 These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC. Phosphatidylcholines 161-163 vasoactive intestinal peptide Homo sapiens 131-134 17158358-2 2007 In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model. Phosphatidylcholines 42-61 tumor necrosis factor Rattus norvegicus 130-139 17158358-2 2007 In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model. Phosphatidylcholines 42-61 interleukin 1 beta Rattus norvegicus 144-152 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 17391797-2 2007 A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 165-184 phosphatidylethanolamine N-methyltransferase Homo sapiens 52-96 17391797-2 2007 A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 165-184 phosphatidylethanolamine N-methyltransferase Homo sapiens 98-102 17272829-5 2007 HDL from hA-ITg SR-BI-/- mice was enriched in sphingomyelin (SM), relative to phosphatidylcholine, and had less associated [35S]LCAT radiolabel and endogenous LCAT activity compared with HDL from hA-ITg mice. Phosphatidylcholines 78-97 scavenger receptor class B member 1 Homo sapiens 16-21 17311918-1 2007 Snake presynaptic phospholipase A2 neurotoxins (SPANs) bind to the presynaptic membrane and hydrolyze phosphatidylcholine with generation of lysophosphatidylcholine (LysoPC) and fatty acid (FA). Phosphatidylcholines 102-121 phospholipase A2 group IB Homo sapiens 18-34 17344474-1 2007 Molecular dynamics simulations coupled with functional analyses of the major yeast phosphatidylinositol/phosphatidylcholine transfer protein Sec14p identify structural elements involved in regulating the ability of Sec14p to execute phospholipid exchange. Phosphatidylcholines 104-123 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 141-147 17344474-1 2007 Molecular dynamics simulations coupled with functional analyses of the major yeast phosphatidylinositol/phosphatidylcholine transfer protein Sec14p identify structural elements involved in regulating the ability of Sec14p to execute phospholipid exchange. Phosphatidylcholines 104-123 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 215-221 17169434-0 2007 A colorimetric assay for measuring phospholipase A2 degradation of phosphatidylcholine at physiological pH. Phosphatidylcholines 67-86 phospholipase A2 group IB Homo sapiens 35-51 17283071-2 2007 Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 51-70 phosphatidylethanolamine N-methyltransferase Mus musculus 146-190 17388516-1 2007 Achatin-I (Gly1-d-Phe2-Ala3-Asp4), known as a neuropeptide containing a d-amino acid, binds to the surface of a zwitterionic phosphatidylcholine (PC) membrane only when the peptide N-terminal amino group is in the ionized state, NH3+ (Kimura, T.; Okamura, E.; Matubayasi, N.; Asami, K.; Nakahara, M. Biophys. Phosphatidylcholines 125-144 threonine aldolase 1, pseudogene Homo sapiens 11-15 17388516-1 2007 Achatin-I (Gly1-d-Phe2-Ala3-Asp4), known as a neuropeptide containing a d-amino acid, binds to the surface of a zwitterionic phosphatidylcholine (PC) membrane only when the peptide N-terminal amino group is in the ionized state, NH3+ (Kimura, T.; Okamura, E.; Matubayasi, N.; Asami, K.; Nakahara, M. Biophys. Phosphatidylcholines 125-144 napsin A aspartic peptidase Homo sapiens 28-32 17367165-7 2007 For the cPLA2alpha C2 domain, the target lipid phosphatidylcholine (PC) appears to be sufficient to drive membrane targeting to an internal membrane mimic at physiological Ca2+ levels, although the results do not rule out a second, unknown target molecule. Phosphatidylcholines 47-66 phospholipase A2 group IVA Homo sapiens 8-18 17367165-7 2007 For the cPLA2alpha C2 domain, the target lipid phosphatidylcholine (PC) appears to be sufficient to drive membrane targeting to an internal membrane mimic at physiological Ca2+ levels, although the results do not rule out a second, unknown target molecule. Phosphatidylcholines 68-70 phospholipase A2 group IVA Homo sapiens 8-18 17283071-2 2007 Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 51-70 phosphatidylethanolamine N-methyltransferase Mus musculus 192-196 17292664-2 2007 Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 64-83 phosphatidylethanolamine N-methyltransferase Mus musculus 92-136 17292664-2 2007 Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 64-83 phosphatidylethanolamine N-methyltransferase Mus musculus 138-142 17258706-4 2007 Mitochondrial phosphatidylethanolamine and phosphatidylcholine from Gpat1-/- liver contained 21% and 67% more arachidonate, respectively, than wildtype controls, and higher amounts of 4-hydroxynonenal, a product of arachidonate peroxidation. Phosphatidylcholines 43-62 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 68-73 17066268-1 2007 The bovine seminal plasma protein PDC-109 modulates the maturation of bull sperm cells by removing lipids, mainly phosphatidylcholine and cholesterol, from their cellular membrane. Phosphatidylcholines 114-133 seminal plasma protein PDC-109 Bos taurus 11-41 17066268-5 2007 From these cells, PDC-109 extracted phosphatidylcholine and sphingomyelin that contained an enrichment of mono- and di-unsaturated fatty acids as well as short-chain and lyso-phosphatidylcholine species. Phosphatidylcholines 36-55 seminal plasma protein PDC-109 Bos taurus 18-25 17349923-0 2007 Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Phosphatidylcholines 23-42 interferon gamma Homo sapiens 89-105 17349923-2 2007 Phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes. Phosphatidylcholines 50-69 surfactant protein C Homo sapiens 71-73 17321580-3 2007 Phosphatidylcholine, the principal component of pulmonary surfactant that maintains small airway patency, is hydrolyzed by sPLA(2). Phosphatidylcholines 0-19 phospholipase A2 group IIA Homo sapiens 123-130 17321580-11 2007 The combined actions of sPLA(2) and lysophospholipase produced dose-dependent and time-dependent losses of surfactant function, concomitant with hydrolysis of phosphatidylcholine and lysophosphatidylcholine. Phosphatidylcholines 159-178 phospholipase A2 group IIA Homo sapiens 24-53 17213195-6 2007 In contrast, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) protein, a key control point in phosphatidylcholine biosynthesis, increased because of stabilization of protein turnover rather than transcriptional activation. Phosphatidylcholines 102-121 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 13-58 17207856-4 2007 VH12 anti-phosphatidylcholine (PtC) IgH transgenic mice provide a model for the induced differentiation of B-1 cells. Phosphatidylcholines 10-29 immunoglobulin heavy chain complex Mus musculus 36-39 17267394-5 2007 TLC and electrospray ionization mass spectrometry analyses of lipids in the pulmonary interstitium showed that phosphatidylcholine and phosphatidylglycerol, which contain palmitic acid and are abundant in normal surfactant lipids, were dramatically decreased in Abca3(-/-) lung. Phosphatidylcholines 111-130 ATP binding cassette subfamily A member 3 Homo sapiens 262-267 17213183-3 2007 We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and enhanced activities of the choline cytidylyltransferase (CCT) and cholinephosphotransferase enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis. Phosphatidylcholines 112-131 X-box binding protein 1 Homo sapiens 26-31 17213195-6 2007 In contrast, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) protein, a key control point in phosphatidylcholine biosynthesis, increased because of stabilization of protein turnover rather than transcriptional activation. Phosphatidylcholines 102-121 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 60-68 17213183-3 2007 We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and enhanced activities of the choline cytidylyltransferase (CCT) and cholinephosphotransferase enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis. Phosphatidylcholines 133-139 X-box binding protein 1 Homo sapiens 26-31 17178780-0 2007 The Psa fimbriae of Yersinia pestis interact with phosphatidylcholine on alveolar epithelial cells and pulmonary surfactant. Phosphatidylcholines 50-69 aminopeptidase puromycin sensitive Homo sapiens 4-7 16731034-2 2007 This concept is illustrated in this review by summarizing recent evidence on Nte1p, a yeast endoplasmic reticulum resident phospholipase B that deacylates PtdCho producing intracellular glycerophosphocholine. Phosphatidylcholines 155-161 lysophospholipase Saccharomyces cerevisiae S288C 77-82 17344490-2 2007 Previously, we showed an association between elevated plasma homocysteine, reduced ratios of S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) and of phosphatidylcholine to phosphatidylethanolamine, and phospholipid malabsorption in children with CF. Phosphatidylcholines 157-176 acyl-CoA synthetase medium chain family member 3 Homo sapiens 145-148 17178780-4 2007 The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays. Phosphatidylcholines 35-54 aminopeptidase puromycin sensitive Homo sapiens 4-7 17178780-4 2007 The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays. Phosphatidylcholines 56-58 aminopeptidase puromycin sensitive Homo sapiens 4-7 17178780-4 2007 The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays. Phosphatidylcholines 56-58 aminopeptidase puromycin sensitive Homo sapiens 121-124 17178780-5 2007 The Psa fimbriae bound to PC in a dose-dependent manner, and binding was inhibited by phosphorylcholine (ChoP) and choline. Phosphatidylcholines 26-28 aminopeptidase puromycin sensitive Homo sapiens 4-7 16963094-2 2007 In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline. Phosphatidylcholines 124-143 patatin like phospholipase domain containing 6 Homo sapiens 35-38 17148553-4 2007 In liposomes containing synthetic phosphatidylcholines (PCs), sPLA(2)X showed no clear selectivity among the various sn-2 unsaturated fatty acids. Phosphatidylcholines 56-59 phospholipase A2 group X Homo sapiens 62-70 17142808-7 2007 Mass spectrometry measurement of >300 phospholipids in lung tissue taken from Abca3(-/-) mice showed a dramatic reduction of phosphatidylglycerol (PG) levels as well as selective reductions in phosphatidylcholine species containing short acyl chains. Phosphatidylcholines 196-215 ATP-binding cassette, sub-family A (ABC1), member 3 Mus musculus 81-86 16963094-2 2007 In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline. Phosphatidylcholines 124-143 phospholamban Homo sapiens 62-77 16963094-2 2007 In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline. Phosphatidylcholines 124-143 phospholamban Homo sapiens 79-82 17260960-4 2007 In Langmuir monolayer studies high-activity (HA) and low-activity (LA) forms of PLTP associated with fluid phosphatidylcholine monolayers spread at the air/buffer interphase. Phosphatidylcholines 107-126 phospholipid transfer protein Homo sapiens 80-84 17189248-10 2007 In addition, the T455A mutation caused a 44% decrease in the amount of human CTP synthetase 1 that was phosphorylated in S. cerevisiae cells, and this was accompanied by a 2.5-fold increase in the cellular concentration of CTP and a 1.5-fold increase in the choline-dependent synthesis of phosphatidylcholine. Phosphatidylcholines 289-308 CTP synthase 1 Homo sapiens 77-93 17184749-1 2007 The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain. Phosphatidylcholines 55-74 cut-like homeobox 1 Rattus norvegicus 174-177 17184749-1 2007 The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain. Phosphatidylcholines 76-82 cut-like homeobox 1 Rattus norvegicus 174-177 17158102-5 2007 Upon overexpression in COS-7 cells, one protein, named rat LRAT-like protein (RLP)-1, catalyzed transfer of a radioactive acyl group from phosphatidylcholine (PC) to PE, resulting in the formation of radioactive NAPE. Phosphatidylcholines 138-157 lecithin retinol acyltransferase Rattus norvegicus 59-63 17158102-5 2007 Upon overexpression in COS-7 cells, one protein, named rat LRAT-like protein (RLP)-1, catalyzed transfer of a radioactive acyl group from phosphatidylcholine (PC) to PE, resulting in the formation of radioactive NAPE. Phosphatidylcholines 159-161 lecithin retinol acyltransferase Rattus norvegicus 59-63 17204250-4 2007 Treatment with TNF-alpha antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA2 IIA protein expression, PLA2 activity and significantly restored phosphatidylcholine levels after tMCAO. Phosphatidylcholines 177-196 tumor necrosis factor Rattus norvegicus 15-24 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. Phosphatidylcholines 148-167 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-130 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. Phosphatidylcholines 148-167 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. Phosphatidylcholines 169-171 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-130 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. Phosphatidylcholines 169-171 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 17179149-2 2007 In all nucleated mammalian cells, PC is synthesized from choline via the Kennedy (CDP-choline) pathway. Phosphatidylcholines 34-36 cut like homeobox 1 Homo sapiens 82-85 17179149-3 2007 The purpose of our study was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to elucidate the mechanism(s) by which AMPK inhibits hepatic PC synthesis. Phosphatidylcholines 167-169 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 61-65 17179149-3 2007 The purpose of our study was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to elucidate the mechanism(s) by which AMPK inhibits hepatic PC synthesis. Phosphatidylcholines 167-169 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 145-149 17184936-3 2007 It has been suggested that NTE is responsible for phosphatidylcholine homeostasis, although its role in neuropathy induction remains unclear. Phosphatidylcholines 50-69 patatin like phospholipase domain containing 6 Bos taurus 27-30 17156888-5 2007 RESULTS: We observed that ethanol feeding resulted in decreased phosphatidylcholine (PC) production by a PEMT-catalyzed reaction. Phosphatidylcholines 64-83 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 105-109 17156888-5 2007 RESULTS: We observed that ethanol feeding resulted in decreased phosphatidylcholine (PC) production by a PEMT-catalyzed reaction. Phosphatidylcholines 85-87 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 105-109 17138935-2 2007 METHODS AND RESULTS: Cultured human aortic endothelial cells were stimulated with tumor necrosis factor (TNF)-alpha in the presence of human recombinant apoE3 solubilized in dimyristoyl phosphatidylcholine liposomes. Phosphatidylcholines 186-205 tumor necrosis factor Homo sapiens 82-115 17138935-2 2007 METHODS AND RESULTS: Cultured human aortic endothelial cells were stimulated with tumor necrosis factor (TNF)-alpha in the presence of human recombinant apoE3 solubilized in dimyristoyl phosphatidylcholine liposomes. Phosphatidylcholines 186-205 apolipoprotein E Homo sapiens 153-158 17237796-3 2007 Here we describe the structure of CETP at 2.2-A resolution, revealing a 60-A-long tunnel filled with two hydrophobic cholesteryl esters and plugged by an amphiphilic phosphatidylcholine at each end. Phosphatidylcholines 166-185 cholesteryl ester transfer protein Homo sapiens 34-38 17093292-1 2007 Basic polysaccharide strongly inhibited the hydrolysis of trioleoylglycerol (TO) emulsified with phosphatidylcholine and taurocholate by either pancreatic lipase or carboxylester lipase. Phosphatidylcholines 97-116 lipase G, endothelial type Rattus norvegicus 155-161 17126953-3 2007 On the other hand, phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes. Phosphatidylcholines 69-88 surfactant protein C Homo sapiens 90-92 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 17184757-1 2007 Neuropathy target esterase (NTE) is a membrane protein present in various tissues whose physiological function has been recently suggested to be the maintenance of phosphatidylcholine homeostasis. Phosphatidylcholines 164-183 patatin like phospholipase domain containing 6 Bos taurus 0-26 17184757-1 2007 Neuropathy target esterase (NTE) is a membrane protein present in various tissues whose physiological function has been recently suggested to be the maintenance of phosphatidylcholine homeostasis. Phosphatidylcholines 164-183 patatin like phospholipase domain containing 6 Bos taurus 28-31 17038637-4 2007 METHODS AND RESULTS: Among inhibitors specific to PKC activators, phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609 limited apoCIII-induced PKC alpha activation and THP-1 cell adhesion. Phosphatidylcholines 66-85 apolipoprotein C3 Homo sapiens 143-150 17209172-4 2007 The available evidence indicates that the quantitatively most important pathways for S-adenosylmethionine-dependent transmethylation in mammals are the syntheses of creatine by guanidinoacetate methyltransferase, of phosphatidylcholine by phosphatidylethanolamine methyltransferase, and of sarcosine by glycine N-methyltransferase. Phosphatidylcholines 216-235 glycine N-methyltransferase Homo sapiens 303-330 17114808-2 2007 Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, acts by transferring an acyl group from the sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 159-178 lecithin retinol acyltransferase Homo sapiens 0-32 17114808-2 2007 Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, acts by transferring an acyl group from the sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 159-178 lecithin retinol acyltransferase Homo sapiens 34-38 17020537-9 2007 Hsp22 binds more strongly to vesicles made of lipids containing a phosphatidic acid, phosphatidylinositol or phosphatidylserine headgroup (known to be present in the inner leaflet of plasma membrane) compared with lipid vesicles made of a phosphatidylcholine head-group alone. Phosphatidylcholines 239-258 heat shock protein family B (small) member 8 Homo sapiens 0-5 17038637-4 2007 METHODS AND RESULTS: Among inhibitors specific to PKC activators, phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609 limited apoCIII-induced PKC alpha activation and THP-1 cell adhesion. Phosphatidylcholines 66-85 protein kinase C alpha Homo sapiens 159-168 17197234-3 2007 In contrast to PtdCho, which was readily hydrolyzed by group V and X sPLA(2)s, and to a lesser extent by group IIA sPLA(2), the minor ethanolamine, inositol and serine glycerophospholipids exhibited marked resistance to hydrolysis by all three sPLA(2)s. Phosphatidylcholines 15-21 phospholipase A2 group IID Homo sapiens 69-77 16554055-6 2007 However, the apoA-I secreted by PLTP-KO hepatocytes contained less choline PL, differing also in phosphatidylcholine/sphingomyelin ratio and fatty acyl species composition when compared to apoA-I from WT hepatocytes. Phosphatidylcholines 97-116 apolipoprotein A-I Mus musculus 13-19 16554055-6 2007 However, the apoA-I secreted by PLTP-KO hepatocytes contained less choline PL, differing also in phosphatidylcholine/sphingomyelin ratio and fatty acyl species composition when compared to apoA-I from WT hepatocytes. Phosphatidylcholines 97-116 phospholipid transfer protein Mus musculus 32-36 17174597-0 2007 Phosphatidylcholine transfer activity of yeast Sec14p is not essential for its function in vivo. Phosphatidylcholines 0-19 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 47-53 17174597-1 2007 Yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, Sec14p, is essential for protein transport from the Golgi apparatus and for the cell viability. Phosphatidylcholines 32-51 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 75-81 17197234-3 2007 In contrast to PtdCho, which was readily hydrolyzed by group V and X sPLA(2)s, and to a lesser extent by group IIA sPLA(2), the minor ethanolamine, inositol and serine glycerophospholipids exhibited marked resistance to hydrolysis by all three sPLA(2)s. Phosphatidylcholines 15-21 phospholipase A2 group IIA Homo sapiens 69-75 17174597-5 2007 Thus, in vitro PC transfer ability of Sec14p is not required for its essential function(s) in living cells, however, yeast cells having PC transfer deficient Sec14p(D115G) as a sole Sec14p display regulatory abnormalities, including increased phospholipase D mediated PC turnover. Phosphatidylcholines 15-17 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 38-44 17273143-1 2007 The ABCB4 gene codes for a protein involved in the transport of phosphatidylcholine across the canalicular membrane of the hepatocyte. Phosphatidylcholines 64-83 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidylcholines 86-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidylcholines 86-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 17436686-3 2007 LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. Phosphatidylcholines 90-109 selectin E Homo sapiens 26-36 18176897-2 2007 Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. Phosphatidylcholines 107-126 synuclein alpha Rattus norvegicus 24-27 18176897-2 2007 Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. Phosphatidylcholines 128-130 synuclein alpha Rattus norvegicus 24-27 17132109-3 2006 The aim of this study was to investigate whether methionine, its precursors or metabolites [phosphatidylcholine, choline, betaine, S-adenosylmethionine (SAM)] have a modulating effect on tumor necrosis factor alpha (TNF-alpha) production by endotoxin-stimulated human mononuclear leukocytes and whether SAM-dependent polyamines (spermidine, spermine) are mediators of SAM-induced inhibition of TNF-alpha synthesis. Phosphatidylcholines 92-111 tumor necrosis factor Homo sapiens 187-214 17046062-3 2007 Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%. Phosphatidylcholines 123-142 phospholipase A2 group VI Homo sapiens 20-25 17046062-3 2007 Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%. Phosphatidylcholines 144-150 phospholipase A2 group VI Homo sapiens 20-25 17046062-3 2007 Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%. Phosphatidylcholines 180-186 phospholipase A2 group VI Homo sapiens 20-25 18084901-10 2007 The phospholipase A2 activity plays an important role in lung surfactant homeostasis and is responsible for the bulk of the degradation of internalized phosphatidylcholine and its resynthesis by the reacylation pathway. Phosphatidylcholines 152-171 phospholipase A2 group IB Homo sapiens 4-20 17176081-1 2006 A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC). Phosphatidylcholines 176-195 proopiomelanocortin Homo sapiens 29-43 17176081-1 2006 A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC). Phosphatidylcholines 197-199 proopiomelanocortin Homo sapiens 29-43 17082194-5 2006 An affinity-purified tafazzin construct, tagged with the maltose-binding protein, catalyzed both forward and reverse transacylations between cardiolipin and phosphatidylcholine, but was unable to utilize CoA or acyl-CoA as substrates. Phosphatidylcholines 157-176 Tafazzin Drosophila melanogaster 21-29 17082194-6 2006 Whereas tafazzin supported transacylations between various phospholipid-lysophospholipid pairs, it showed the highest rate for the phosphatidylcholine-cardiolipin transacylation. Phosphatidylcholines 131-150 Tafazzin Drosophila melanogaster 8-16 17082194-8 2006 The data show that Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine. Phosphatidylcholines 147-166 Tafazzin Drosophila melanogaster 30-38 17169600-5 2007 Ghrelin appeared to activate extracellular signal-regulated kinases 1/2 through a calcium-independent novel protein kinase C isoform which may utilize diacylglycerol derived from hydrolysis of phosphatidylcholine rather than from phosphatidylinositol. Phosphatidylcholines 193-212 mitogen-activated protein kinase 3 Homo sapiens 29-71 17210739-1 2007 Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to cellular lipid metabolism. Phosphatidylcholines 78-97 sphingomyelin synthase 2 Rattus norvegicus 0-24 17210739-1 2007 Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to cellular lipid metabolism. Phosphatidylcholines 78-97 sphingomyelin synthase 2 Rattus norvegicus 26-30 17046831-6 2006 Reconstituted HDL composed mainly of apolipoprotein A-I and phosphatidylcholine mimicked the SR-BI-sensitive part of HDL-induced actions. Phosphatidylcholines 60-79 scavenger receptor class B member 1 Homo sapiens 93-98 17077289-2 2006 Among sPLA2s, the human group X (hGX) enzyme has the highest catalytic activity toward phosphatidylcholine, one of the major phospholipid species of cell membranes and low-density lipoprotein (LDL). Phosphatidylcholines 87-106 phospholipase A2 group IID Homo sapiens 6-12 16824732-6 2006 Vesicles of phosphatidylcholine (PtdCho) stimulated only twofold PtdIns(3,4,5)P(3) 5-phosphatase activity of SHIP2. Phosphatidylcholines 12-31 inositol polyphosphate phosphatase like 1 Homo sapiens 109-114 16824732-6 2006 Vesicles of phosphatidylcholine (PtdCho) stimulated only twofold PtdIns(3,4,5)P(3) 5-phosphatase activity of SHIP2. Phosphatidylcholines 33-39 inositol polyphosphate phosphatase like 1 Homo sapiens 109-114 17121526-4 2006 Plasma PLTP activity was determined as the transfer of radiolabelled phosphatidylcholine from small unilamellar phosphatidylcholine vesicles to ultracentrifugally isolated HDL. Phosphatidylcholines 69-88 phospholipid transfer protein Homo sapiens 7-11 17121526-4 2006 Plasma PLTP activity was determined as the transfer of radiolabelled phosphatidylcholine from small unilamellar phosphatidylcholine vesicles to ultracentrifugally isolated HDL. Phosphatidylcholines 112-131 phospholipid transfer protein Homo sapiens 7-11 17096689-3 2006 Interestingly, these recombinant proteins were able to reduce H2O2, cumene hydroperoxide, phosphatidylcholine and linoleic acid hydroperoxides using thioredoxin but not glutathione or NADPH as an electron donor. Phosphatidylcholines 90-109 thioredoxin Homo sapiens 149-160 17432083-9 2006 Phosphatidylcholine treatment decreased the leukocyte rolling and sticking, preserved the FCD and improved the RBCV The mast cell degranulation and MPO activity diminished significantly in the muscle layer. Phosphatidylcholines 0-19 myeloperoxidase Rattus norvegicus 148-151 17005997-7 2006 TG-lipase was able to hydrolyze the major phospholipid components of the lipid droplets, phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 89-108 uncharacterized protein Drosophila melanogaster 0-9 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 98-101 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 169-213 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 215-219 17189343-7 2006 PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine. Phosphatidylcholines 219-238 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 81-86 17189343-7 2006 PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine. Phosphatidylcholines 219-238 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 81-86 16997918-5 2006 Herein, we describe the application of EPR spectroscopy to probe the local dynamics and the electrostatic microenvironment of phosphatidylcholine (PtdCho) bound by Sec14p in a soluble protein-PtdCho complex. Phosphatidylcholines 126-145 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 164-170 17008322-4 2006 This severe pulmonary defect in sPLA2-V Tg mice was attributable to marked reduction of the lung surfactant phospholipids, phosphatidylcholine and phosphatidylglycerol. Phosphatidylcholines 123-142 phospholipase A2, group X Mus musculus 32-37 17077504-1 2006 Sec14p is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the budding yeast Saccharomyces cerevisiae and is the founding member of a large eukaryotic protein superfamily. Phosphatidylcholines 50-69 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-6 17087498-1 2006 Recent publications described the formation of millimeter-length fibers by diverse lipid-binding proteins (e.g., histone H1, cytochrome c, indolicidin, and endostatin) when they are mixed with 80:20 phosphatidylcholine/phosphatidylserine vesicles. Phosphatidylcholines 199-218 collagen type XVIII alpha 1 chain Homo sapiens 156-166 17030901-1 2006 We have previously provided evidence suggesting that phosphatidic acid, possibly derived from the hydrolysis of phosphatidylcholine by phospholipase D (PLD), is involved in platelet-derived growth factor (PDGF)-mediated increases in extracellular signal-regulated kinase (ERK) activity and DNA synthesis in rat hepatic stellate cells (HSC), the primary fibrogenic cells of the liver. Phosphatidylcholines 112-131 Eph receptor B1 Rattus norvegicus 233-270 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 97-105 17042754-4 2006 Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals. Phosphatidylcholines 0-19 C-8 sterol isomerase ERG2 Saccharomyces cerevisiae S288C 45-49 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 7-55 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 57-63 17042754-4 2006 Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals. Phosphatidylcholines 0-19 C-5 sterol desaturase Saccharomyces cerevisiae S288C 54-58 17042754-4 2006 Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals. Phosphatidylcholines 0-19 sterol 24-C-methyltransferase Saccharomyces cerevisiae S288C 97-101 17046758-4 2006 Consistent with the structure-based predictions, functional studies demonstrated that Arg120His PC-TP was inactive, suggesting that this mutation contributes to the deficiencies in phosphatidylcholine metabolism observed in NZO mice. Phosphatidylcholines 181-200 phosphatidylcholine transfer protein Mus musculus 96-101 16962105-1 2006 C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 0-18 17015841-4 2006 Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine. Phosphatidylcholines 114-133 patatin-like phospholipase domain containing 6 Mus musculus 0-26 17015841-4 2006 Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine. Phosphatidylcholines 114-133 patatin-like phospholipase domain containing 6 Mus musculus 28-31 16962105-1 2006 C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 20-23 16828950-4 2006 Based on this model, the enhanced interaction power of TPL, as compared to that of HPL, into a phosphatidylcholine monolayer film, could be explained. Phosphatidylcholines 95-114 pancreatic triacylglycerol lipase Meleagris gallopavo 55-58 16828950-4 2006 Based on this model, the enhanced interaction power of TPL, as compared to that of HPL, into a phosphatidylcholine monolayer film, could be explained. Phosphatidylcholines 95-114 galectin 1 Homo sapiens 83-86 16854530-1 2006 The MDR3 protein is a transporter of phosphatidylcholine on the canalicular membrane of human hepatocytes. Phosphatidylcholines 37-56 ATP binding cassette subfamily B member 4 Homo sapiens 4-8 16891548-8 2006 Disruption of both PLD zeta1 and PLD zeta2 function resulted in a smaller decrease in phosphatidylcholine and a smaller increase in digalactosyldiacylglycerol in phosphorus-starved roots. Phosphatidylcholines 86-105 phospholipase D P1 Arabidopsis thaliana 19-42 16779768-4 2006 The phosphatidylcholine/cholesterol/galactocerebroside lipid composition (PC/Chol/GalC, 1:0.35:0.125) was deposited onto the chitosan films. Phosphatidylcholines 4-23 galactosylceramidase Homo sapiens 82-86 16837646-11 2006 Thus, Lpla2 has broad positional specificity for the sn-1 and sn-2 acyl groups in phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 82-101 phospholipase A2, group XV Mus musculus 6-11 16763094-9 2006 Selective inhibition of iPLA(2)beta, but not iPLA(2)gamma, decreased several arachidonic acid-containing phospholipids, including 16:1-20:4, 16:0-20:4, 18:1-20:4, and 18:0-20:4 phosphatidylcholine, showing that the ability of iPLA(2)beta inhibitors to decrease cell growth correlates with their ability to decrease arachidonic acid-containing phospholipids. Phosphatidylcholines 177-196 phospholipase A2 group VI Homo sapiens 24-35 16927188-2 2006 METHODS: AFM images of phosphatidylcholine/cholesterol vesicles were obtained using a mucin-coated mica substrate. Phosphatidylcholines 23-42 LOC100508689 Homo sapiens 86-91 16962371-5 2006 Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins. Phosphatidylcholines 71-90 phospholipase A2 group X Homo sapiens 16-23 16962371-5 2006 Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins. Phosphatidylcholines 92-94 phospholipase A2 group X Homo sapiens 16-23 16961322-4 2006 The obtained fluorinated phosphatidylcholine poly(carbonate urethane)s (FPCPCU) possessed high molecular weight, narrower molecular weight distribution, and good mechanical properties as characterized by GPC and Instron, showing an increased hydrophilicity and a possible arrangement of surface structure as characterized by water contact angle. Phosphatidylcholines 25-44 glycophorin C (Gerbich blood group) Homo sapiens 204-207 16857758-9 2006 IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes. Phosphatidylcholines 67-86 interleukin-1 alpha Ovis aries 0-9 17025673-9 2006 For comparison with similar phospholipids, the zeta potential of phosphatidylcholine interacting with Gd3+ was measured, showing an analogous behavior. Phosphatidylcholines 65-84 GRDX Homo sapiens 102-105 16769123-1 2006 The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway. Phosphatidylcholines 107-126 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 29-32 16769123-1 2006 The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway. Phosphatidylcholines 107-126 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 82-85 17171187-1 2006 Cytidine 5"-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the biosynthetic pathway of structural phospholipids in cell membranes, particularly phosphatidylcholine. Phosphatidylcholines 174-193 cut like homeobox 1 Homo sapiens 30-33 16777854-5 2006 Phosphatidylcholine turnover increased rapidly following inositol addition, a response that requires the participation of Nte1p, an endoplasmic reticulum-localized phospholipase B. Phosphatidylcholines 0-19 lysophospholipase Saccharomyces cerevisiae S288C 122-127 16924104-7 2006 Second, CLP gives a considerable (3-fold) increase in the amount of LTA(4) formed by 5LO, when present together with phosphatidylcholine. Phosphatidylcholines 117-136 coactosin like F-actin binding protein 1 Homo sapiens 8-11 31627634-4 2006 In children, DM-1 was ascertained to be accompanied by not only atherogenic serum lipid metabolic disturbances (the elevated levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol), but also by the impaired lipid spectrum of erythrocytic membranes (reductions in the level of total lipids and the fraction of phosphatidylcholine (PC) with an increase in the level of fractions of tysophosphatidylcholine and phosphaUdylinositol; elevated levels of saturated fatty acids and decreased levels of unsaturated fatty acids in the fractions of PC and phosphatidylethanolamlne; the enhanced microviscosity of deep membranous layers and the modified outer membranous ones). Phosphatidylcholines 348-367 immunoglobulin heavy diversity 1-7 Homo sapiens 13-17 16766520-3 2006 As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 89-92 16874306-0 2006 Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. Phosphatidylcholines 11-30 CD1b molecule Homo sapiens 94-98 16874306-5 2006 Using isoelectric focusing, native mass spectrometry and resolving the crystal structure at 1.8 A resolution, we found that human CD1b is simultaneously associated with endogenous phosphatidylcholine (PC) and a 41-44 carbon atoms-long spacer molecule. Phosphatidylcholines 180-199 CD1b molecule Homo sapiens 130-134 16874306-5 2006 Using isoelectric focusing, native mass spectrometry and resolving the crystal structure at 1.8 A resolution, we found that human CD1b is simultaneously associated with endogenous phosphatidylcholine (PC) and a 41-44 carbon atoms-long spacer molecule. Phosphatidylcholines 201-203 CD1b molecule Homo sapiens 130-134 16766520-3 2006 As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading. Phosphatidylcholines 71-73 cut like homeobox 1 Homo sapiens 89-92 16843818-5 2006 PLD catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA). Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16831444-4 2006 The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer. Phosphatidylcholines 204-223 FYN binding protein 1 Homo sapiens 93-97 16831444-4 2006 The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer. Phosphatidylcholines 204-223 PML-RARA regulated adaptor molecule 1 Homo sapiens 103-109 16879426-3 2006 Sphingomyelin synthase 1 functions by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol. Phosphatidylcholines 80-99 sphingomyelin synthase 1 Mus musculus 0-24 16820874-1 2006 Choline kinase alpha (ChoKalpha) is a metabolic enzyme involved in the synthesis of phosphatidylcholine, recently implicated in cancer onset since it is overexpressed in a variety of human cancers such as mammary, lung, colorectal and prostate adenocarcinomas. Phosphatidylcholines 84-103 choline kinase alpha Homo sapiens 0-20 16702602-0 2006 Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. Phosphatidylcholines 42-61 ATP binding cassette subfamily G member 1 Homo sapiens 65-70 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16702602-6 2006 Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1. Phosphatidylcholines 102-121 ATP binding cassette subfamily G member 1 Homo sapiens 36-41 16702602-6 2006 Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1. Phosphatidylcholines 102-121 ATP binding cassette subfamily A member 1 Homo sapiens 46-51 16702602-6 2006 Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1. Phosphatidylcholines 123-125 ATP binding cassette subfamily G member 1 Homo sapiens 36-41 16702602-6 2006 Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1. Phosphatidylcholines 123-125 ATP binding cassette subfamily A member 1 Homo sapiens 46-51 16880524-1 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 108-127 phospholipase A2, group XV Mus musculus 2-28 16880524-1 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 108-127 phospholipase A2, group XV Mus musculus 30-35 16880524-8 2006 A marked accumulation of phospholipids, in particular phosphatidylethanolamine and phosphatidylcholine, was found in the alveolar macrophages, the peritoneal macrophages, and the spleens of Lpla2-/- mice. Phosphatidylcholines 83-102 phospholipase A2, group XV Mus musculus 190-195 16732058-2 2006 It has also been suggested that iPLA(2)beta is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate incorporation into phosphatidylcholine (PC). Phosphatidylcholines 95-114 phospholipase A2, group VI Mus musculus 32-43 16754725-0 2006 Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14. Phosphatidylcholines 0-19 CD14 molecule Homo sapiens 113-117 16732058-2 2006 It has also been suggested that iPLA(2)beta is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate incorporation into phosphatidylcholine (PC). Phosphatidylcholines 117-119 phospholipase A2, group VI Mus musculus 32-43 16756957-1 2006 Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. Phosphatidylcholines 115-134 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 16756957-1 2006 Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. Phosphatidylcholines 115-134 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 46-50 16709158-1 2006 The major PI (phosphatidylinositol)/PC (phosphatidylcholine)-transfer protein in yeast, Sec14p, co-ordinates lipid metabolism with protein transport from the Golgi complex. Phosphatidylcholines 40-59 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 88-94 16638972-1 2006 Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme. Phosphatidylcholines 39-58 ras homolog family member A Homo sapiens 127-131 16638972-1 2006 Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme. Phosphatidylcholines 39-58 cell division cycle 42 Homo sapiens 133-138 16638972-1 2006 Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme. Phosphatidylcholines 39-58 Rac family small GTPase 1 Homo sapiens 144-148 16737317-0 2006 Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C. Fluorogenic analogues of phosphatidylcholine and lysophosphatidylcholine, DDPB and lysoDDPB, were synthesized by an enzyme-assisted strategy. Phosphatidylcholines 117-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-70 16389649-5 2006 METHODS: Plasma PLTP activity was assayed by measuring the transfer of radiolabelled phosphatidylcholine from liposomes to HDL; apo AI and B by rate nephelometry and apo E by a 2-point turbidimetric assay. Phosphatidylcholines 85-104 phospholipid transfer protein Homo sapiens 16-20 16669622-3 2006 Wide line 2H and 31P NMR spectra of phospholipid vesicles revealed that alpha-syn associates with membranes containing lipids with anionic headgroups and can disrupt the integrity of the lipid bilayer, but the protein has little effect on membranes of zwitterionic phosphatidylcholine. Phosphatidylcholines 265-284 synuclein alpha Homo sapiens 72-81 16925521-3 2006 Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA. Phosphatidylcholines 167-186 macrophage scavenger receptor 1 Mus musculus 10-36 16925521-3 2006 Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA. Phosphatidylcholines 167-186 macrophage scavenger receptor 1 Mus musculus 38-41 16925521-3 2006 Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA. Phosphatidylcholines 167-186 macrophage scavenger receptor 1 Mus musculus 116-119 16925521-3 2006 Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA. Phosphatidylcholines 167-186 macrophage scavenger receptor 1 Mus musculus 116-119 16582425-10 2006 It has previously been shown that defects in phosphatidylcholine synthesis (cho2 and opi3) yield the Opi(-) phenotype because of a buildup of PA. Phosphatidylcholines 45-64 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 76-80 16582425-10 2006 It has previously been shown that defects in phosphatidylcholine synthesis (cho2 and opi3) yield the Opi(-) phenotype because of a buildup of PA. Phosphatidylcholines 45-64 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 85-89 16641205-6 2006 Phosphatidylcholine comprised 41 +/- 19% of the total phospholipid in the BAL fluid of the ABCA3 group compared with 78 +/- 3% and 68 +/- 18%, p = 0.008 and 0.05, of the CON and SP-B groups, respectively. Phosphatidylcholines 0-19 ATP binding cassette subfamily A member 3 Homo sapiens 91-96 16641205-6 2006 Phosphatidylcholine comprised 41 +/- 19% of the total phospholipid in the BAL fluid of the ABCA3 group compared with 78 +/- 3% and 68 +/- 18%, p = 0.008 and 0.05, of the CON and SP-B groups, respectively. Phosphatidylcholines 0-19 surfactant protein B Homo sapiens 178-182 16641205-8 2006 We conclude that mutations in ABCA3 are associated with surfactant that is deficient in phosphatidylcholine and has decreased function, suggesting that ABCA3 plays an important role in pulmonary surfactant phospholipid homeostasis. Phosphatidylcholines 88-107 ATP binding cassette subfamily A member 3 Homo sapiens 30-35 16641205-8 2006 We conclude that mutations in ABCA3 are associated with surfactant that is deficient in phosphatidylcholine and has decreased function, suggesting that ABCA3 plays an important role in pulmonary surfactant phospholipid homeostasis. Phosphatidylcholines 88-107 ATP binding cassette subfamily A member 3 Homo sapiens 152-157 16565064-0 2006 Cytochrome C interaction with cardiolipin/phosphatidylcholine model membranes: effect of cardiolipin protonation. Phosphatidylcholines 42-61 cytochrome c, somatic Homo sapiens 0-12 16565064-1 2006 Resonance energy transfer between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cytochrome c (cyt c) as an acceptor has been employed to explore the protein binding to model membranes, composed of phosphatidylcholine and cardiolipin (CL). Phosphatidylcholines 222-241 cytochrome c, somatic Homo sapiens 105-117 16565064-1 2006 Resonance energy transfer between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cytochrome c (cyt c) as an acceptor has been employed to explore the protein binding to model membranes, composed of phosphatidylcholine and cardiolipin (CL). Phosphatidylcholines 222-241 cytochrome c, somatic Homo sapiens 119-124 16631150-4 2006 It is shown that the spectral peaks assigned to the methyl head groups of phosphatidylcholine and sphingomyelin in the (1)H spectra of LDL exhibit line broadening when otherwise free thiol groups of apoB are covalently modified by methanethiosulfonate spin label. Phosphatidylcholines 74-93 apolipoprotein B Homo sapiens 199-203 16732739-6 2006 Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br-) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine. Phosphatidylcholines 226-245 myeloperoxidase Homo sapiens 99-102 16461407-5 2006 By using phosphatidylcholine/phosphatidylglycerol model systems, we show that local enrichment of anionic lipids into fluid domains triggers PLA2-IIA activity. Phosphatidylcholines 9-28 phospholipase A2 group IIA Homo sapiens 141-145 16732739-6 2006 Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br-) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine. Phosphatidylcholines 226-245 myeloperoxidase Homo sapiens 176-179 16754327-2 2006 The PC and other glycerophospholipid compositions of membranes change dynamically through stimulus-dependent and independent pathways, principally by the action of two different types of enzymes; phospholipase A2 [EC 3.1.1.4] and acyl-CoA:lysophospholipid acyltransferase [EC 2.3.1.23]. Phosphatidylcholines 4-6 phospholipase A2 group IB Homo sapiens 196-212 16840176-1 2006 In the authors" previous studies, they found that phosphatidylcholine-specific phospholipase C (PC-PLC) and phosphatidylinositol-specific phospholipase C (PI-PLC) played contrary roles in the apoptosis of vascular endothelial cells (VECs), but the mechanism underlying the phenomenon remains unclear. Phosphatidylcholines 50-69 phospholipase C beta 1 Homo sapiens 155-161 16611377-8 2006 The phosphatidylcholine:phosphatidylethanolamine ratio in rat liver increased with rising dietary methionine concentration; the relative mRNA concentrations of phosphatidylethanolamine N-methyltransferase and cystathionine beta-synthase remained unaffected. Phosphatidylcholines 4-23 cystathionine beta synthase Rattus norvegicus 209-236 16679290-2 2006 In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 10-12 phosphatidylethanolamine N-methyltransferase Mus musculus 80-124 16679290-2 2006 In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 10-12 phosphatidylethanolamine N-methyltransferase Mus musculus 126-130 16679290-4 2006 Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile. Phosphatidylcholines 112-114 phosphatidylethanolamine N-methyltransferase Mus musculus 48-52 16679290-4 2006 Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile. Phosphatidylcholines 112-114 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 57-90 16679290-4 2006 Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile. Phosphatidylcholines 112-114 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 92-96 16500904-11 2006 These results suggest that the ATPase activity of ABCA1 is stimulated preferentially by phospholipids with choline head groups, phosphatidylcholine and sphingomyelin. Phosphatidylcholines 128-147 dynein axonemal heavy chain 8 Homo sapiens 31-37 16618126-6 2006 The purified Atp8a1 is inactive in detergent micelles or in micelles containing phosphatidylcholine, phosphatidic acid, or phosphatidylinositol, is minimally activated by phosphatidylglycerol or phosphatidylethanolamine (PE), and is maximally activated by PS. Phosphatidylcholines 80-99 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 13-19 16500904-2 2006 Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL). Phosphatidylcholines 85-104 apolipoprotein A1 Homo sapiens 0-18 16500904-11 2006 These results suggest that the ATPase activity of ABCA1 is stimulated preferentially by phospholipids with choline head groups, phosphatidylcholine and sphingomyelin. Phosphatidylcholines 128-147 ATP binding cassette subfamily A member 1 Homo sapiens 50-55 16500904-2 2006 Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL). Phosphatidylcholines 85-104 ATP binding cassette subfamily A member 1 Homo sapiens 28-33 16466701-2 2006 We reported in a previous study that HePC interferes with phosphatidylcholine (PC) synthesis in HepG2 cells via both CDP-choline and phosphatidylethanolamine (PE) methylation. Phosphatidylcholines 39-41 cut like homeobox 1 Homo sapiens 117-120 16500904-2 2006 Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL). Phosphatidylcholines 85-104 apolipoprotein A1 Homo sapiens 122-128 16500904-6 2006 Purified ABCA1 showed robust ATPase activity when reconstituted in liposomes made of synthetic phosphatidylcholine. Phosphatidylcholines 95-114 ATP binding cassette subfamily A member 1 Homo sapiens 9-14 16500904-6 2006 Purified ABCA1 showed robust ATPase activity when reconstituted in liposomes made of synthetic phosphatidylcholine. Phosphatidylcholines 95-114 dynein axonemal heavy chain 8 Homo sapiens 29-35 16674912-0 2006 Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position. Phosphatidylcholines 56-76 paraoxonase 1 Homo sapiens 26-30 16609691-0 2006 Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity. Phosphatidylcholines 114-133 phospholipid transfer protein Homo sapiens 7-36 16674912-6 2006 In contrast, phosphatidylserine and phosphatidic acid (> or =0.1 mM) inhibited both activities Further, such a preferable stimulation of arylesterase activity by phosphatidylcholines was also reproduced with VLDL-bound PON1, although to a less extent. Phosphatidylcholines 165-185 paraoxonase 1 Homo sapiens 222-226 16445898-3 2006 In this paper a simple model system was used: unsaturated phosphatidylcholine (PC) vesicles were treated with HOCl in the presence of varying NaNO2 concentrations and the yield of reaction products was determined by MALDI-TOF MS: the extent of chlorohydrin generation was significantly reduced in the presence of NaNO2 because HOCl is consumed by the oxidation of NO2- to NO3-. Phosphatidylcholines 79-81 NBL1, DAN family BMP antagonist Homo sapiens 372-375 16415354-8 2006 Silencing of ABCA3 expression also reduced vesicular uptake of surfactant lipids phosphatidylcholine, sphingomyelin, and cholesterol but not phosphatidylethanolamine. Phosphatidylcholines 81-100 ATP binding cassette subfamily A member 3 Homo sapiens 13-18 16415354-9 2006 We conclude that ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures. Phosphatidylcholines 60-79 ATP binding cassette subfamily A member 3 Homo sapiens 17-22 16553452-2 2006 Steady-state fluorescence anisotropy measurements of diphenylhexatriene (DPH) chain-labeled phosphatidylcholine (DPH-PC) revealed significant dips at several POPE-to-phospholipid mole fractions (X(PE)"s) when the cholesterol-to-lipid mole fraction (X(CHOL)) was fixed at 0.00, 0.35, 0.40, and 0.50. Phosphatidylcholines 92-111 damage specific DNA binding protein 1 Homo sapiens 195-200 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. Phosphatidylcholines 169-188 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 22-27 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. Phosphatidylcholines 169-188 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 32-37 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. Phosphatidylcholines 190-192 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 22-27 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. Phosphatidylcholines 190-192 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 32-37 16445995-0 2006 Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 89-108 chromogranin A Sus scrofa 16-30 16309859-4 2006 NTE is localised to the cytoplasmic face of the endoplasmic reticulum (ER) and catalyses the deacylation of ER-membrane phosphatidylcholine (PtdCho) to soluble products-glycerophosphocholine and fatty acids. Phosphatidylcholines 120-139 patatin-like phospholipase domain containing 6 Mus musculus 0-3 16466687-1 2006 CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 92-111 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 16309859-4 2006 NTE is localised to the cytoplasmic face of the endoplasmic reticulum (ER) and catalyses the deacylation of ER-membrane phosphatidylcholine (PtdCho) to soluble products-glycerophosphocholine and fatty acids. Phosphatidylcholines 141-147 patatin-like phospholipase domain containing 6 Mus musculus 0-3 16309859-6 2006 Yeast mutants lacking NTE are viable because they maintain membrane homeostasis by reducing the rate of PtdCho synthesis. Phosphatidylcholines 104-110 patatin-like phospholipase domain containing 6 Mus musculus 22-25 16380371-0 2006 CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. Phosphatidylcholines 35-54 phospholipase A2 group IB Homo sapiens 90-106 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 24-40 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 42-46 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 98-113 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 16466687-1 2006 CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 92-111 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-49 16466687-1 2006 CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 113-119 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 16466687-1 2006 CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 113-119 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-49 16371353-0 2006 A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 97-116 choline kinase beta Mus musculus 56-75 16453359-4 2006 These compounds contain alpha-D-glucose in the sn-2 position of the glycerol backbone of phosphatidylcholine (PC) and platelet-activating factor (PAF), which gives rise to 2-glucophosphatidylcholine (Glc-PC) and 1-O-octadecyl-2-O-alpha-d-glucopyranosyl-sn-2-glycero-3-phosphatidylcholine (Glc-PAF), respectively. Phosphatidylcholines 89-108 PCNA clamp associated factor Homo sapiens 293-296 16453359-4 2006 These compounds contain alpha-D-glucose in the sn-2 position of the glycerol backbone of phosphatidylcholine (PC) and platelet-activating factor (PAF), which gives rise to 2-glucophosphatidylcholine (Glc-PC) and 1-O-octadecyl-2-O-alpha-d-glucopyranosyl-sn-2-glycero-3-phosphatidylcholine (Glc-PAF), respectively. Phosphatidylcholines 110-112 PCNA clamp associated factor Homo sapiens 293-296 16376450-2 2006 The multidrug resistant 2 (Mdr2) P-glycoprotein encodes for the canalicular phospholipid transporter, and Mdr2 (+/-) mice secrete 40% less phosphatidylcholine than wild-type mice. Phosphatidylcholines 139-158 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 27-31 16376450-2 2006 The multidrug resistant 2 (Mdr2) P-glycoprotein encodes for the canalicular phospholipid transporter, and Mdr2 (+/-) mice secrete 40% less phosphatidylcholine than wild-type mice. Phosphatidylcholines 139-158 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 106-110 16412504-7 2006 PMCA activity was two to three times higher when the surrounding phosphatidylcholine molecules contained acyl chains that were ordered (stiff) compared to disordered (fluid) acyl chains. Phosphatidylcholines 65-84 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 0-4 16412504-9 2006 PMCA associates much more strongly with phosphatidylcholine containing disordered hydrocarbon chains than ordered hydrocarbon chains. Phosphatidylcholines 40-59 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 0-4 16371353-5 2006 CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine. Phosphatidylcholines 193-212 choline kinase beta Homo sapiens 0-4 16371353-5 2006 CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine. Phosphatidylcholines 193-212 choline kinase alpha Homo sapiens 29-43 16371353-5 2006 CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine. Phosphatidylcholines 193-212 choline kinase alpha Homo sapiens 0-3 16259620-4 2006 CA-C had a greater affinity for negatively charged lipids (phosphatidic acid and phosphatidylserine) than for zwitterionic lipids [PC/Cho/SM (equimolar mixture of phosphatidylcholine, cholesterol and sphingomyelin) and phosphatidylcholine]. Phosphatidylcholines 163-182 carbonic anhydrase 2 Homo sapiens 0-4 16259620-4 2006 CA-C had a greater affinity for negatively charged lipids (phosphatidic acid and phosphatidylserine) than for zwitterionic lipids [PC/Cho/SM (equimolar mixture of phosphatidylcholine, cholesterol and sphingomyelin) and phosphatidylcholine]. Phosphatidylcholines 219-238 carbonic anhydrase 2 Homo sapiens 0-4 16286468-1 2006 Studies involving pharmacologic inhibition or transient reduction of Group VIA phospholipase A2 (iPLA2beta) expression have suggested that it is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels, rates of arachidonate incorporation into phospholipids, and degradation of excess phosphatidylcholine (PC). Phosphatidylcholines 193-212 phospholipase A2 group IB Rattus norvegicus 79-95 16482629-11 2006 In contrast, phosphatidylcholine pretreatment prevented the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity and the mast cell degranulation increased. Phosphatidylcholines 13-32 myeloperoxidase Canis lupus familiaris 128-143 16286468-1 2006 Studies involving pharmacologic inhibition or transient reduction of Group VIA phospholipase A2 (iPLA2beta) expression have suggested that it is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels, rates of arachidonate incorporation into phospholipids, and degradation of excess phosphatidylcholine (PC). Phosphatidylcholines 193-212 phospholipase A2 group VI Rattus norvegicus 97-106 16845888-0 2006 Regulation of phosphatidylcholine homeostasis by Sec14. Phosphatidylcholines 14-33 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 49-54 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. Phosphatidylcholines 41-43 phospholipase A2 Oryctolagus cuniculus 82-98 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. Phosphatidylcholines 41-43 phospholipase A2 Oryctolagus cuniculus 100-104 16146428-4 2006 In the present paper, we report that alpha-syn bound to small unilamellar liposomes composed of phosphatidylcholine/phosphatidic acid is resistant to oxidation and nitration when compared with soluble alpha-syn. Phosphatidylcholines 96-115 synuclein alpha Homo sapiens 37-46 16845888-3 2006 Yeast studies have determined that the phosphatidylcholine and (or) phosphatidylinositol binding protein, Sec14, is a major regulator of phosphatidylcholine homeostasis. Phosphatidylcholines 39-58 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 106-111 16845888-3 2006 Yeast studies have determined that the phosphatidylcholine and (or) phosphatidylinositol binding protein, Sec14, is a major regulator of phosphatidylcholine homeostasis. Phosphatidylcholines 137-156 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 106-111 16845888-4 2006 Sec14 itself regulates vesicular transport from the Golgi, and the interrelationship between phosphatidylcholine metabolism and membrane movement within the cell is described in detail. Phosphatidylcholines 93-112 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 16400173-2 2006 PLD catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid (PA) and choline. Phosphatidylcholines 32-51 phospholipase D Saccharomyces cerevisiae S288C 0-3 16679530-4 2006 PMCA was photolabeled in mixed micelles containing detergent, the phosphatidylcholine photoactivatable analog 1-palmitoyl-2-[9-[2"-[125I]iodo-4"- (trifluoromethyldiazirinyl)-benzyloxycarbonyl]-nonaoyl]-sn-glycero-3-phosphocholine, and different amounts of dimyristoyl phosphatidylcholine (PC). Phosphatidylcholines 66-85 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 0-4 16679530-4 2006 PMCA was photolabeled in mixed micelles containing detergent, the phosphatidylcholine photoactivatable analog 1-palmitoyl-2-[9-[2"-[125I]iodo-4"- (trifluoromethyldiazirinyl)-benzyloxycarbonyl]-nonaoyl]-sn-glycero-3-phosphocholine, and different amounts of dimyristoyl phosphatidylcholine (PC). Phosphatidylcholines 289-291 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 0-4 16679530-6 2006 We determined a maximum number of 17 +/- 1 molecules of PC in close contact with the transmembrane surface per PMCA molecule. Phosphatidylcholines 56-58 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 111-115 16719778-2 2006 ChoK is important for the generation of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM) and subsequently for the cell division. Phosphatidylcholines 74-93 choline kinase alpha Mus musculus 0-4 16719778-2 2006 ChoK is important for the generation of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM) and subsequently for the cell division. Phosphatidylcholines 95-97 choline kinase alpha Mus musculus 0-4 16679769-3 2006 PS can be decarboxylated to PE, and PC is synthesized from PE by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 36-38 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 65-109 16679769-3 2006 PS can be decarboxylated to PE, and PC is synthesized from PE by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 36-38 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 111-115 16054134-9 2006 We show that this activity uses palmitoyl coenzyme A as an acyl donor, unlike LRAT which uses phosphatidylcholine. Phosphatidylcholines 94-113 lecithin retinol acyltransferase Homo sapiens 78-82 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17047345-8 2006 The increased PC content was attributed to an increased synthesis, as measured by [methyl-(14)C]choline incorporation into PC and high CTP:phosphocholine cytidylyltransferase-alpha mRNA expression. Phosphatidylcholines 14-16 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 135-180 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16226406-1 2005 Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG). Phosphatidylcholines 176-195 sphingomyelin synthase 1 Mus musculus 0-24 16226406-1 2005 Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG). Phosphatidylcholines 176-195 sphingomyelin synthase 1 Mus musculus 26-30 16157598-1 2005 Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes. Phosphatidylcholines 0-19 cut-like homeobox 1 Mus musculus 41-44 16332136-2 2005 The kinetics of breakdown of the bovine milk allergen alpha-lactalbumin during in vitro gastrointestinal digestion was found to be altered by interactions with physiologically relevant levels of phosphatidylcholine (PC), a surfactant that is abundant both in milk and is actively secreted by the stomach. Phosphatidylcholines 195-214 lactalbumin alpha Bos taurus 54-71 16157598-1 2005 Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 87-126 16332136-2 2005 The kinetics of breakdown of the bovine milk allergen alpha-lactalbumin during in vitro gastrointestinal digestion was found to be altered by interactions with physiologically relevant levels of phosphatidylcholine (PC), a surfactant that is abundant both in milk and is actively secreted by the stomach. Phosphatidylcholines 216-218 lactalbumin alpha Bos taurus 54-71 16157598-1 2005 Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 147-153 16157598-1 2005 Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, beta isoform Mus musculus 158-164 16236715-8 2005 Oxidized phosphatidylcholine (1-palmitoyl-2-linoleoyl) when hydrolyzed with phospholipase A(2) also evoked intracellular calcium mobilization in G2A-expressing cells. Phosphatidylcholines 9-28 G protein-coupled receptor 132 Homo sapiens 145-148 16204231-1 2005 Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast. Phosphatidylcholines 23-42 Lem3p Saccharomyces cerevisiae S288C 99-104 16204231-1 2005 Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast. Phosphatidylcholines 23-42 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 106-111 16204231-1 2005 Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast. Phosphatidylcholines 23-42 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 117-122 16236715-9 2005 These results indicate that G2A is activated by oxidized free fatty acids produced by oxidation and subsequent hydrolysis of phosphatidylcholine or cholesteryl linoleate. Phosphatidylcholines 125-144 G protein-coupled receptor 132 Homo sapiens 28-31 16172116-1 2005 In eukaryotes, neuropathy target esterase (Nte1p in yeast) deacylates phosphatidylcholine derived exclusively from the CDP-choline pathway to produce glycerophosphocholine (GroPCho) and release two fatty acids. Phosphatidylcholines 70-89 lysophospholipase Saccharomyces cerevisiae S288C 43-48 16099870-1 2005 Phosphatidylcholine transfer protein (PC-TP) is a steroidogenic acute regulatory-related transfer domain protein that is enriched in liver cytosol and binds phosphatidylcholines with high specificity. Phosphatidylcholines 157-177 phosphatidylcholine transfer protein Mus musculus 0-36 16099870-1 2005 Phosphatidylcholine transfer protein (PC-TP) is a steroidogenic acute regulatory-related transfer domain protein that is enriched in liver cytosol and binds phosphatidylcholines with high specificity. Phosphatidylcholines 157-177 phosphatidylcholine transfer protein Mus musculus 38-43 16099870-2 2005 In tissue culture systems, PC-TP promotes ATP-binding cassette protein A1-mediated efflux of cholesterol and phosphatidylcholine molecules as nascent pre-beta-high-density lipoprotein (HDL) particles. Phosphatidylcholines 109-128 phosphatidylcholine transfer protein Mus musculus 27-32 16550803-10 2005 In contrast, PC pretreatment reversed the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity increases, and the mast cell degranulation. Phosphatidylcholines 13-15 myeloperoxidase Canis lupus familiaris 110-125 16109976-11 2005 Anti-CD18 antibody administration inhibited only endotoxin-induced but not IL-1-induced increases in surfactant protein mRNA and surfactant saturated phosphatidylcholine. Phosphatidylcholines 150-169 integrin beta-2 Ovis aries 5-9 16201749-5 2005 Surface plasmon resonance was employed to quantitate the interaction between PP1c gamma and immobilized mixed lipid vesicles of PA/phosphatidylcholine (PC) or PC alone. Phosphatidylcholines 131-150 protein phosphatase 1 catalytic subunit gamma Homo sapiens 77-81 16216074-3 2005 To investigate the structural basis of phospholipid binding further, GM2AP was cocrystallized with phosphatidylcholine (PC), known to interact with GM2AP. Phosphatidylcholines 99-118 GM2 ganglioside activator protein Mus musculus 148-153 16274224-0 2005 Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms. Phosphatidylcholines 38-57 phosphatidylinositol transfer protein, beta Rattus norvegicus 13-21 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. Phosphatidylcholines 115-134 phosphatidylethanolamine N-methyltransferase Mus musculus 143-187 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. Phosphatidylcholines 115-134 phosphatidylethanolamine N-methyltransferase Mus musculus 189-193 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. Phosphatidylcholines 136-138 phosphatidylethanolamine N-methyltransferase Mus musculus 143-187 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. Phosphatidylcholines 136-138 phosphatidylethanolamine N-methyltransferase Mus musculus 189-193 16137924-5 2005 Unlike wild-type yeast, mutants lacking NTE activity cannot deacylate CDP-choline pathway-synthesized phosphatidylcholine (PtdCho) to glycerophosphocholine (GroPCho) and fatty acids. Phosphatidylcholines 102-121 patatin like phospholipase domain containing 6 Homo sapiens 40-43 16153613-5 2005 CDP-choline liposomes deliver the agent intact to the brain, circumventing the rate-limiting, cytidine triphosphate:phosphocholine cytidylyltransferase in phosphatidylcholine synthesis. Phosphatidylcholines 155-174 cut-like homeobox 1 Rattus norvegicus 0-3 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidylcholines 57-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidylcholines 57-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16156665-3 2005 The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC). Phosphatidylcholines 281-300 phospholipase A2 group IID Homo sapiens 53-61 16156665-3 2005 The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC). Phosphatidylcholines 302-304 phospholipase A2 group IID Homo sapiens 53-61 16137924-5 2005 Unlike wild-type yeast, mutants lacking NTE activity cannot deacylate CDP-choline pathway-synthesized phosphatidylcholine (PtdCho) to glycerophosphocholine (GroPCho) and fatty acids. Phosphatidylcholines 123-129 patatin like phospholipase domain containing 6 Homo sapiens 40-43 16137924-7 2005 A complex of PtdCho and Sec14p, a yeast phospholipid-binding protein, both inhibits the rate-limiting step in PtdCho synthesis and enhances deacylation of PtdCho by NTE. Phosphatidylcholines 13-19 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 24-30 16166305-8 2005 In particular, TRAIL-induced alteration of mitochondrial lipids follows an imbalance in the cellular homeostasis of phosphatidylcholine, which results in an elevation in diacylglycerol (DAG). Phosphatidylcholines 116-135 TNF superfamily member 10 Homo sapiens 15-20 16137924-7 2005 A complex of PtdCho and Sec14p, a yeast phospholipid-binding protein, both inhibits the rate-limiting step in PtdCho synthesis and enhances deacylation of PtdCho by NTE. Phosphatidylcholines 13-19 patatin like phospholipase domain containing 6 Homo sapiens 165-168 16142924-4 2005 Using a freeze-thaw procedure, purified rOCT1 was reconstituted into proteoliposomes formed from phosphatidylcholine, phosphatidylserine, and cholesterol. Phosphatidylcholines 97-116 solute carrier family 22 member 1 Rattus norvegicus 40-45 16195591-1 2005 Lymphatic recovery of cholesterol infused into the duodenum as bile salt micelles containing phosphatidylcholine (PC) was accelerated by the co-administration of phospholipase A2 in bile and pancreatic juice diverted rats. Phosphatidylcholines 93-112 phospholipase A2 group IB Rattus norvegicus 162-178 16131098-4 2005 The conversion efficiency of phosphatidyl choline to choline was 50% at 0.2 mL min(-1). Phosphatidylcholines 29-49 CD59 molecule (CD59 blood group) Homo sapiens 79-85 16195591-1 2005 Lymphatic recovery of cholesterol infused into the duodenum as bile salt micelles containing phosphatidylcholine (PC) was accelerated by the co-administration of phospholipase A2 in bile and pancreatic juice diverted rats. Phosphatidylcholines 114-116 phospholipase A2 group IB Rattus norvegicus 162-178 16463138-2 2005 We investigated Bax and tBid interactions with (i) phosphatidylcholine (PC) monolayer as the main component of the outer leaflet of the outer membrane, (ii) with phosphatidylethanolamine (PE) and phosphatidylserine (PS) that are present in the inner leaflet and (iii) with a mixed PC/PE/Cardiolipin (CL) monolayer of the contact sites between the outer and inner membranes. Phosphatidylcholines 51-70 BCL2 associated X, apoptosis regulator Homo sapiens 16-19 16213900-1 2005 BACKGROUND: Lysophosphatidylcholine (LysoPC) is a product of phosphatidylcholine hydrolysis by phospholipase A2, which is associated with atherosclerosis. Phosphatidylcholines 16-35 phospholipase A2 group IB Homo sapiens 95-111 15901801-1 2005 Our previous study showed that rilmenidine, a selective I(1)-imidazoline receptor agonist, enhanced the phosphorylation of mitogen-activated protein kinase (MAPK)(p42/44), via the phosphatidylcholine-specific phospholipase C pathway in the pheochromocytoma cell line (PC12). Phosphatidylcholines 180-199 mitogen activated protein kinase 3 Rattus norvegicus 157-161 16092060-4 2005 The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I). Phosphatidylcholines 4-24 apolipoprotein A1 Homo sapiens 84-91 15979580-0 2005 GPI-alkaline phosphatase insertion into phosphatidylcholine monolayers: phase behavior and morphology changes. Phosphatidylcholines 40-59 glucose-6-phosphate isomerase Bos taurus 0-3 15967578-5 2005 AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+. Phosphatidylcholines 152-171 coagulation factor X Homo sapiens 77-86 15967578-5 2005 AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+. Phosphatidylcholines 173-175 coagulation factor X Homo sapiens 77-86 16051693-1 2005 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 16051693-1 2005 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 16051517-5 2005 Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells. Phosphatidylcholines 141-160 phospholipase A2 activating protein Homo sapiens 47-51 16051517-5 2005 Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells. Phosphatidylcholines 162-164 phospholipase A2 activating protein Homo sapiens 47-51 16092060-4 2005 The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I). Phosphatidylcholines 4-24 apolipoprotein A1 Homo sapiens 151-158 16092060-4 2005 The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I). Phosphatidylcholines 26-29 apolipoprotein A1 Homo sapiens 84-91 16092060-4 2005 The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I). Phosphatidylcholines 26-29 apolipoprotein A1 Homo sapiens 151-158 15911624-3 2005 We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement. Phosphatidylcholines 52-71 StAR related lipid transfer domain containing 10 Homo sapiens 29-36 16200394-8 2005 Thus, using information on the known molecular structures of tested phospholipids, a phosphatidylcholine residue in alpha-position and a short chain length fatty acid esterified in beta-position seem essential for activation of ecto-5"-nucleotidase by glycerophospholipids. Phosphatidylcholines 85-104 5'-nucleotidase ecto Homo sapiens 228-248 15911624-3 2005 We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement. Phosphatidylcholines 73-75 StAR related lipid transfer domain containing 10 Homo sapiens 29-36 15911624-7 2005 StarD10 was further shown to bind lipids in vivo by cross-linking of protein expressed in transfected HEK-293T cells with photoactivable phosphatidylcholine. Phosphatidylcholines 137-156 StAR related lipid transfer domain containing 10 Homo sapiens 0-7 15834125-6 2005 The lack of phospholipase A(2) activity of EL and its ability to liberate [(14)C]FA from [(14)C]lysophosphatidylcholine (lyso-PC) led us to conclude that EL-mediated deacylation of phosphatidylcholine (PC) is initiated at the sn-1 position, followed by the release of the remaining FA from the lyso-PC intermediate. Phosphatidylcholines 100-119 lipase G, endothelial type Homo sapiens 43-45 15936720-5 2005 Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC. Phosphatidylcholines 87-89 choline phosphotransferase 1 Homo sapiens 0-25 15936720-5 2005 Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC. Phosphatidylcholines 87-89 choline phosphotransferase 1 Homo sapiens 27-30 15936720-12 2005 Furthermore, the activity of CPT in forming PC is increased in the breast cancer cell lines cultured for 24 h. Additionally, we examined the CPT activity in the presence of nanomolar concentrations of Ro5-4864. Phosphatidylcholines 44-46 choline phosphotransferase 1 Homo sapiens 29-32 15919656-1 2005 The Saccharomyces cerevisiae CKI1-encoded choline kinase catalyzes the committed step in phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 89-108 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 29-33 16002697-0 2005 Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. Phosphatidylcholines 57-76 CD1d1 antigen Mus musculus 27-31 16002697-2 2005 In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. Phosphatidylcholines 79-98 CD1d1 antigen Mus musculus 65-69 15849246-2 2005 In this work isothermal titration calorimetry, circular dichroism spectroscopy, and two-photon microscopy are used to study the interaction of lipid-free apolipoprotein A-I (apoA-I) with small unilamellar vesicles (SUVs) of 1-palmitoyl, 2-oleoyl phosphatidylcholine (POPC) and sphingomyelin (SM), with and without cholesterol. Phosphatidylcholines 267-271 apolipoprotein A1 Homo sapiens 154-172 15849246-2 2005 In this work isothermal titration calorimetry, circular dichroism spectroscopy, and two-photon microscopy are used to study the interaction of lipid-free apolipoprotein A-I (apoA-I) with small unilamellar vesicles (SUVs) of 1-palmitoyl, 2-oleoyl phosphatidylcholine (POPC) and sphingomyelin (SM), with and without cholesterol. Phosphatidylcholines 267-271 apolipoprotein A1 Homo sapiens 174-180 15924269-3 2005 Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center. Phosphatidylcholines 84-103 proline rich transmembrane protein 2 Homo sapiens 42-45 15924269-3 2005 Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center. Phosphatidylcholines 105-107 proline rich transmembrane protein 2 Homo sapiens 42-45 15924269-3 2005 Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center. Phosphatidylcholines 105-107 proline rich transmembrane protein 2 Homo sapiens 214-217 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 steroidogenic acute regulatory protein Homo sapiens 112-118 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 3 Homo sapiens 119-125 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 5 Homo sapiens 126-132 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 5 Homo sapiens 134-140 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 phosphatidylcholine transfer protein Homo sapiens 142-148 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 10 Homo sapiens 149-156 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 StAR related lipid transfer domain containing 10 Homo sapiens 158-165 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. Phosphatidylcholines 36-55 ceramide transporter 1 Homo sapiens 170-177 15953354-5 2005 Overexpression of EL resulted in enhanced hydrolysis of extracellular high-density lipoprotein (HDL)-associated sn-2-labeled [(14)C]20 : 4 phosphatidylcholine. Phosphatidylcholines 139-158 lipase G, endothelial type Homo sapiens 18-20 15982005-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the rate-limiting step in phosphatidylcholine (PC) synthesis, and its activity is regulated by reversible association with membranes, mediated by an amphipathic helical domain M. Here we describe a new feature of the CCTalpha isoform, vesicle tethering. Phosphatidylcholines 82-101 phosphate cytidylyltransferase 1A, choline Homo sapiens 273-281 15982005-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the rate-limiting step in phosphatidylcholine (PC) synthesis, and its activity is regulated by reversible association with membranes, mediated by an amphipathic helical domain M. Here we describe a new feature of the CCTalpha isoform, vesicle tethering. Phosphatidylcholines 103-105 phosphate cytidylyltransferase 1A, choline Homo sapiens 273-281 15764643-2 2005 Secretion of saturated phosphatidylcholine was decreased 40-60% by expression of TGF-alpha. Phosphatidylcholines 23-42 transforming growth factor alpha Mus musculus 81-90 15866882-10 2005 In contrast to cPLA(2)alpha, cPLA(2)zeta preferred phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 79-98 phospholipase A2, group IVF Mus musculus 29-40 15834125-1 2005 We assessed the ability of endothelial lipase (EL) to hydrolyze the sn-1 and sn-2 fatty acids (FAs) from HDL phosphatidylcholine. Phosphatidylcholines 109-128 lipase G, endothelial type Homo sapiens 27-45 15834125-1 2005 We assessed the ability of endothelial lipase (EL) to hydrolyze the sn-1 and sn-2 fatty acids (FAs) from HDL phosphatidylcholine. Phosphatidylcholines 109-128 lipase G, endothelial type Homo sapiens 47-49 15834125-6 2005 The lack of phospholipase A(2) activity of EL and its ability to liberate [(14)C]FA from [(14)C]lysophosphatidylcholine (lyso-PC) led us to conclude that EL-mediated deacylation of phosphatidylcholine (PC) is initiated at the sn-1 position, followed by the release of the remaining FA from the lyso-PC intermediate. Phosphatidylcholines 126-128 lipase G, endothelial type Homo sapiens 43-45 15806137-5 2005 The complementary nature of the fatty acid alterations in CL and PC suggested that fatty acid transfer between these two lipids was inhibited in BTHS. Phosphatidylcholines 65-67 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 145-149 15966743-2 2005 When 100% phosphatidylcholine (PC) in standard vesicles was gradually replaced with either DG or PE, the stability of CYP1A2 increased; the incubation time-dependent destruction of spectrally detectable P450, decrease of catalytic activity, reduction of intrinsic fluorescence, and increased sensitivity to trypsin digestion were significantly alleviated. Phosphatidylcholines 10-29 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 118-124 15966743-2 2005 When 100% phosphatidylcholine (PC) in standard vesicles was gradually replaced with either DG or PE, the stability of CYP1A2 increased; the incubation time-dependent destruction of spectrally detectable P450, decrease of catalytic activity, reduction of intrinsic fluorescence, and increased sensitivity to trypsin digestion were significantly alleviated. Phosphatidylcholines 31-33 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 118-124 15829484-0 2005 Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. Phosphatidylcholines 125-144 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-25 15829484-4 2005 The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice. Phosphatidylcholines 15-34 stearoyl-Coenzyme A desaturase 1 Mus musculus 260-264 15829484-4 2005 The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice. Phosphatidylcholines 36-38 stearoyl-Coenzyme A desaturase 1 Mus musculus 260-264 15829484-8 2005 The incorporation of [(3)H]glycerol into PC was increased by 2.5-fold in Scd1-/- primary hepatocytes compared with those of wild type mice. Phosphatidylcholines 41-43 stearoyl-Coenzyme A desaturase 1 Mus musculus 73-77 15829484-10 2005 Our study revealed that SCD1 deficiency specifically increases CCT activity by promoting its translocation into membrane and enhances PC biosynthesis in liver. Phosphatidylcholines 134-136 stearoyl-Coenzyme A desaturase 1 Mus musculus 24-28 15788406-0 2005 Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 19-38 mitogen-activated protein kinase 1 Homo sapiens 53-56 15788406-6 2005 Expression of truncated CCTalpha mutants lacking proline-directed sites within the C-terminal phosphorylation domain partially blocked oxysterol-mediated inhibition of PtdCho synthesis. Phosphatidylcholines 168-174 phosphate cytidylyltransferase 1A, choline Homo sapiens 24-32 15788406-7 2005 Mutagenesis of Ser315 within CCTalpha was both required and sufficient to confer significant resistance to 22-HC/9-cis-RA inhibition of PtdCho synthesis. Phosphatidylcholines 136-142 phosphate cytidylyltransferase 1A, choline Homo sapiens 29-37 15938614-7 2005 Alpha-synuclein deficiency decreased the incorporation rate and fractional turnover of 16:0 in a number of phospholipid classes, but also increased the incorporation rate and fractional turnover of 16:0 in the choline glycerophospholipids. Phosphatidylcholines 210-238 synuclein, alpha Mus musculus 0-15 15772421-8 2005 These results demonstrate that LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate PtdCho metabolism in pulmonary epithelia. Phosphatidylcholines 140-146 ceramide synthase 5 Homo sapiens 31-36 15628972-2 2005 PC-TP (phosphatidylcholine transfer protein) is a START (steroidogenic acute regulatory protein-related lipid transfer) domain protein that catalyses the intermembrane transfer of phosphatidylcholines and promotes apolipoprotein AI-mediated lipid efflux when overexpressed in the cytosol of Chinese-hamster ovary cells. Phosphatidylcholines 180-200 phosphatidylcholine transfer protein Cricetulus griseus 0-5 15949677-3 2005 In this report, we studied the synergistic antioxidant role of zeaxanthin and GSTP1 in egg yolk phosphatidylcholine (EYPC) liposomes using hydrophilic 2,2"-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) and lipophilic 2,2"-azobis(2,4-dimethylvaleronitrile) (AMVN) as lipid peroxyl radical generators. Phosphatidylcholines 96-115 glutathione S-transferase pi 1 Homo sapiens 78-83 15713672-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) is a multi-domain enzyme that regulates phosphatidylcholine synthesis. Phosphatidylcholines 86-105 CCT Homo sapiens 41-44 15628972-2 2005 PC-TP (phosphatidylcholine transfer protein) is a START (steroidogenic acute regulatory protein-related lipid transfer) domain protein that catalyses the intermembrane transfer of phosphatidylcholines and promotes apolipoprotein AI-mediated lipid efflux when overexpressed in the cytosol of Chinese-hamster ovary cells. Phosphatidylcholines 180-200 apolipoprotein A-I Cricetulus griseus 214-231 15617515-3 2005 Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p. Phosphatidylcholines 152-171 oxysterol-binding protein KES1 Saccharomyces cerevisiae S288C 38-43 15617515-3 2005 Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p. Phosphatidylcholines 152-171 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 189-195 15588231-6 2005 At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)>PtdIns>PtdCho (phosphatidylcholine>PtdEtn (phosphatidylethanolamine). Phosphatidylcholines 135-154 lysophospholipase Saccharomyces cerevisiae S288C 67-72 15846601-1 2005 BACKGROUND: CDP-choline (cytidine 5"-diphosphocholine) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischaemia to free fatty acids and free radicals. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 12-15 15588231-6 2005 At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)>PtdIns>PtdCho (phosphatidylcholine>PtdEtn (phosphatidylethanolamine). Phosphatidylcholines 135-154 lysophospholipase Saccharomyces cerevisiae S288C 77-82 15794656-3 2005 Insertion of TH1 into large unilamellar phosphatidylcholine vesicles was followed by monitoring tryptophan fluorescence. Phosphatidylcholines 40-59 negative elongation factor complex member C/D Homo sapiens 13-16 15863370-2 2005 Such modification of the molecular species of these lipid classes requires deacylation and reacylation reactions and for phosphatidylcholines, lysophosphatidylcholine acyltransferase (LPCAT) and a coenzyme A-independent transacylase (CoAIT) can each be involved. Phosphatidylcholines 121-141 lysophosphatidylcholine acyltransferase 1 Homo sapiens 143-182 15863370-3 2005 Since previous studies have shown a significant IFNgamma- and TNFalpha-induced modification of phosphatidylcholine species, we have examined whether these inflammatory cytokines alter the activity of reacylation enzymes in the human monocyte cell line MonoMac 6 (MM6). Phosphatidylcholines 95-114 tumor necrosis factor Homo sapiens 62-70 15516491-7 2005 Phosphatidylcholine, the major phospholipid in surfactant and the greatest potential source for generation of lysophospholipids, was susceptible to hydrolysis by group IB, group V, and group X sPLA(2)s, but not group IIA or IID. Phosphatidylcholines 0-19 phospholipase A2 group IID Homo sapiens 193-201 15736058-9 2005 We have confirmed the presence of PC in the lower joint cavity of rat TMJs as well as on the mandibular condylar surface layer, which was colocalized with hyaluronic acid and fibronectin respectively. Phosphatidylcholines 34-36 fibronectin 1 Rattus norvegicus 175-186 15692104-2 2005 METHODS AND RESULTS: We found that CRP and annexin A5 at physiological concentrations bind Ca++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. Phosphatidylcholines 120-139 C-reactive protein Homo sapiens 35-38 15692104-2 2005 METHODS AND RESULTS: We found that CRP and annexin A5 at physiological concentrations bind Ca++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. Phosphatidylcholines 120-139 annexin A5 Homo sapiens 43-53 15618226-4 2005 Based on amino acid sequence similarity to a bacterial phosphatidylcholine-hydrolyzing phospholipase C, six putative phospholipase Cs were identified in the Arabidopsis genome, one of which, NPC4, showed significant transcriptional activation upon phosphate limitation. Phosphatidylcholines 55-74 phospholipase C1 Arabidopsis thaliana 87-102 15798219-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 103-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 15798219-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 103-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 15798219-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 124-130 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 15798219-1 2005 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 124-130 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 15772346-0 2005 Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. Phosphatidylcholines 78-97 swiss cheese Drosophila melanogaster 8-20 15772346-0 2005 Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. Phosphatidylcholines 78-97 patatin like phospholipase domain containing 6 Homo sapiens 21-47 15772346-3 2005 NTE reacts with organophosphate compounds that cause a paralyzing axonal degeneration in humans and has been shown to degrade endoplasmic reticulum-associated phosphatidylcholine (PtdCho) in cultured mammalian cells. Phosphatidylcholines 180-186 patatin like phospholipase domain containing 6 Homo sapiens 0-3 15618226-0 2005 A novel phosphatidylcholine-hydrolyzing phospholipase C induced by phosphate starvation in Arabidopsis. Phosphatidylcholines 8-27 phospholipase C1 Arabidopsis thaliana 40-55 15618226-2 2005 We report a novel phospholipase C that hydrolyzes phosphatidylcholine and is greatly induced in response to phosphate deprivation in Arabidopsis. Phosphatidylcholines 50-69 phospholipase C1 Arabidopsis thaliana 18-33 15618226-3 2005 Since phosphatidylcholine-hydrolyzing activity by phospholipase C was highly up-regulated in phosphate-deprived plants, gene expression of some phospholipase C was expected to be induced during phosphate starvation. Phosphatidylcholines 6-25 phospholipase C1 Arabidopsis thaliana 50-65 15618226-3 2005 Since phosphatidylcholine-hydrolyzing activity by phospholipase C was highly up-regulated in phosphate-deprived plants, gene expression of some phospholipase C was expected to be induced during phosphate starvation. Phosphatidylcholines 6-25 phospholipase C1 Arabidopsis thaliana 144-159 16010981-6 2005 During receptor-coupled cell activation, phospholipase A2 (PLA2) converts PC and PA to lysoPC and lysoPA, respectively; PI is converted to PIP2 by successive enzymatic phosphorylation by PI 4-kinase and PIP 5-kinase; and phospholipase C (PLC) degrades PIP2 to diacylglycerol and inositol 1,4,5-trisphosphate. Phosphatidylcholines 74-76 LOC104974671 Bos taurus 41-57 16010981-6 2005 During receptor-coupled cell activation, phospholipase A2 (PLA2) converts PC and PA to lysoPC and lysoPA, respectively; PI is converted to PIP2 by successive enzymatic phosphorylation by PI 4-kinase and PIP 5-kinase; and phospholipase C (PLC) degrades PIP2 to diacylglycerol and inositol 1,4,5-trisphosphate. Phosphatidylcholines 74-76 LOC104974671 Bos taurus 59-63 15611060-0 2005 Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p. Phosphatidylcholines 30-49 lysophospholipase Saccharomyces cerevisiae S288C 0-5 15611060-0 2005 Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p. Phosphatidylcholines 30-49 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 78-84 15611060-3 2005 Nte1p, the product of open reading frame YML059c, is an integral membrane phospholipase against CDP-Cho-derived PC producing intracellular glycerophosphocholine (GPCho) and free fatty acids. Phosphatidylcholines 112-114 lysophospholipase Saccharomyces cerevisiae S288C 0-5 15611060-6 2005 Instead, newly synthesized PC was degraded by phospholipase D (Spo14p). Phosphatidylcholines 27-29 phospholipase D Saccharomyces cerevisiae S288C 46-61 15611060-6 2005 Instead, newly synthesized PC was degraded by phospholipase D (Spo14p). Phosphatidylcholines 27-29 phospholipase D Saccharomyces cerevisiae S288C 63-69 15611060-9 2005 Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p. Phosphatidylcholines 60-62 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 102-108 15611060-9 2005 Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p. Phosphatidylcholines 60-62 lysophospholipase Saccharomyces cerevisiae S288C 110-115 15611060-9 2005 Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p. Phosphatidylcholines 60-62 phospholipase D Saccharomyces cerevisiae S288C 134-140 15611060-9 2005 Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p. Phosphatidylcholines 60-62 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 173-178 15611060-12 2005 Beyond the new PC metabolic control features we ascribe to Sfh2p and Sfh4p we also describe a second role for Sec14p in mediating PC homeostasis. Phosphatidylcholines 15-17 Csr1p Saccharomyces cerevisiae S288C 59-64 15611060-12 2005 Beyond the new PC metabolic control features we ascribe to Sfh2p and Sfh4p we also describe a second role for Sec14p in mediating PC homeostasis. Phosphatidylcholines 130-132 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 110-116 15618226-4 2005 Based on amino acid sequence similarity to a bacterial phosphatidylcholine-hydrolyzing phospholipase C, six putative phospholipase Cs were identified in the Arabidopsis genome, one of which, NPC4, showed significant transcriptional activation upon phosphate limitation. Phosphatidylcholines 55-74 non-specific phospholipase C4 Arabidopsis thaliana 191-195 15618226-5 2005 Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity. Phosphatidylcholines 102-121 non-specific phospholipase C4 Arabidopsis thaliana 47-51 15618226-5 2005 Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity. Phosphatidylcholines 102-121 non-specific phospholipase C4 Arabidopsis thaliana 71-75 15618226-5 2005 Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity. Phosphatidylcholines 102-121 phospholipase C1 Arabidopsis thaliana 134-149 15618226-7 2005 Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation. Phosphatidylcholines 102-121 non-specific phospholipase C4 Arabidopsis thaliana 35-39 15618226-7 2005 Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation. Phosphatidylcholines 102-121 non-specific phospholipase C4 Arabidopsis thaliana 76-80 15618226-7 2005 Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation. Phosphatidylcholines 102-121 phospholipase C1 Arabidopsis thaliana 134-149 15576839-1 2005 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 157-177 phosphatidylcholine transfer protein Mus musculus 0-36 15728476-12 2005 Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression. Phosphatidylcholines 72-91 CD38 antigen Mus musculus 27-31 15728476-12 2005 Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression. Phosphatidylcholines 72-91 CD38 antigen Mus musculus 194-198 15576839-1 2005 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 157-177 phosphatidylcholine transfer protein Mus musculus 38-43 15728476-12 2005 Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression. Phosphatidylcholines 72-91 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 231-244 15728476-12 2005 Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression. Phosphatidylcholines 72-91 cyclin D2 Mus musculus 262-271 15728476-12 2005 Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression. Phosphatidylcholines 93-95 CD38 antigen Mus musculus 27-31 15686962-1 2005 BACKGROUND AND PURPOSE: Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial effects in a number of CNS injury models including cerebral ischemia. Phosphatidylcholines 121-140 cut-like homeobox 1 Rattus norvegicus 68-71 15635091-2 2005 Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 245-264 choline-phosphate cytidylyltransferase A Cricetulus griseus 119-164 15635091-2 2005 Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 245-264 choline-phosphate cytidylyltransferase A Cricetulus griseus 166-174 15635091-2 2005 Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 266-272 choline-phosphate cytidylyltransferase A Cricetulus griseus 119-164 15635091-2 2005 Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis. Phosphatidylcholines 266-272 choline-phosphate cytidylyltransferase A Cricetulus griseus 166-174 15628842-1 2005 Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS). Phosphatidylcholines 174-193 synaptotagmin 1 Homo sapiens 117-132 15550377-0 2005 Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. Phosphatidylcholines 41-60 ATP-binding cassette, sub-family A (ABC1), member 7 Mus musculus 0-5 15754464-4 2005 Plasma PLTP activity was assayed by measuring the transfer of radiolabeled phosphatidylcholine from liposomes to HDL and high-sensitivity C-reactive protein (CRP) by immunoturbidimetric assay in 280 type 2 diabetic patients and 105 controls. Phosphatidylcholines 75-94 phospholipid transfer protein Homo sapiens 7-11 15607900-4 2005 We originally reported that PON1 had phospholipase activity toward oxidized phosphatidylcholine (J. Biol. Phosphatidylcholines 76-95 paraoxonase 1 Homo sapiens 28-32 15607900-17 2005 PON1 preparations free of PAF-AH activity showed no phospholipase activity when reconstituted into apolipoprotein AI-phosphatidylcholine complexes. Phosphatidylcholines 117-136 apolipoprotein A1 Homo sapiens 99-116 15628842-1 2005 Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS). Phosphatidylcholines 174-193 secretoglobin family 2B member 3, pseudogene Homo sapiens 134-137 15628842-1 2005 Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS). Phosphatidylcholines 195-197 synaptotagmin 1 Homo sapiens 117-132 15628842-1 2005 Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS). Phosphatidylcholines 195-197 secretoglobin family 2B member 3, pseudogene Homo sapiens 134-137 15628842-9 2005 EPR spectroscopy indicates that the C2B domain has different interactions with PC/PS membranes containing 1 mol % phosphatidylinositol 4,5-bisphosphate. Phosphatidylcholines 79-81 secretoglobin family 2B member 3, pseudogene Homo sapiens 36-39 15588906-5 2005 We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes. Phosphatidylcholines 194-213 fibronectin 1 Homo sapiens 108-119 15588906-5 2005 We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes. Phosphatidylcholines 194-213 fibronectin 1 Homo sapiens 121-123 15588906-5 2005 We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes. Phosphatidylcholines 215-217 fibronectin 1 Homo sapiens 108-119 15588906-5 2005 We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes. Phosphatidylcholines 215-217 fibronectin 1 Homo sapiens 121-123 16055952-2 2005 PC synthesis is controlled by cellular levels of its precursor, cytidine-5"-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. Phosphatidylcholines 0-2 cut-like homeobox 1 Rattus norvegicus 97-100 15501933-3 2005 Octylglucoside-solubilized rhodopsin was incorporated by detergent dilution into solid-supported bilayers composed either of egg phosphatidylcholine or various mixtures of a nonlamellar-forming lipid (dioleoylphosphatidylethanolamine; DOPE) together with a lamellar-forming lipid (dioleoylphosphatidylcholine; DOPC). Phosphatidylcholines 129-148 rhodopsin Homo sapiens 27-36 15665518-5 2005 PLD-catalyzed conversion of phosphatidylcholine to phosphatydilethanol (PetOH), in the presence of ethanol, was monitored by thin layer chromatography. Phosphatidylcholines 28-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 15956784-0 2005 C2C12 skeletal muscle cells exposure to phosphatidylcholine triggers IGF-1 like-responses. Phosphatidylcholines 40-59 insulin-like growth factor 1 Mus musculus 69-74 15652523-4 2005 Fluorescence analyses demonstrated that the BODIPY fatty acid--albumin complex was translocated into the lens, where the BODIPY fatty acid was incorporated in a time dependent manner into numerous lipids, including phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. Phosphatidylcholines 215-234 albumin Homo sapiens 63-70 15498769-0 2004 Increased phosphatidylcholine production but disrupted glycogen metabolism in fetal type II cells of mice that overexpress CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 10-29 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 123-162 15756928-5 2005 CDP-choline might increase the PC levels by attenuating PLA(2) stimulation and loss of CCT activity. Phosphatidylcholines 31-33 cut like homeobox 1 Homo sapiens 0-3 15756928-5 2005 CDP-choline might increase the PC levels by attenuating PLA(2) stimulation and loss of CCT activity. Phosphatidylcholines 31-33 phospholipase A2 group IB Homo sapiens 56-62 15498769-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 103-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 15498769-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 103-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 15498769-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 124-130 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 15498769-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho). Phosphatidylcholines 124-130 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 15569411-4 2004 (2) VIP (10(-8) mol/L) enhanced the contents of total phospholipids and phosphatidylcholine in lung explants. Phosphatidylcholines 72-91 vasoactive intestinal peptide Homo sapiens 4-7 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-26 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 28-31 15385540-1 2004 Homeostasis of phosphatidylcholine (PC) is regulated by the opposing actions between CTP:phosphocholine cytidylyltransferase (CT) and the group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)). Phosphatidylcholines 15-34 phospholipase A2 group VI Homo sapiens 187-194 15385540-1 2004 Homeostasis of phosphatidylcholine (PC) is regulated by the opposing actions between CTP:phosphocholine cytidylyltransferase (CT) and the group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)). Phosphatidylcholines 36-38 phospholipase A2 group VI Homo sapiens 187-194 15385540-6 2004 The accumulation of PC correlates with decreased iPLA(2) activity, suggesting that regulation of this enzyme contributes to phospholipid accumulation. Phosphatidylcholines 20-22 phospholipase A2 group VI Homo sapiens 49-56 15569411-8 2004 CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway. Phosphatidylcholines 43-62 vasoactive intestinal peptide Homo sapiens 12-15 15569411-8 2004 CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway. Phosphatidylcholines 43-62 phosphate cytidylyltransferase 1A, choline Homo sapiens 150-158 15569411-8 2004 CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway. Phosphatidylcholines 43-62 vasoactive intestinal peptide Homo sapiens 174-177 15522829-8 2004 Taken together with our previous observations that both Abeta peptides may induce hydrolysis of phosphatidylcholine, the present results provide evidence that this process is cooperatively mediated by cPLA(2) activation/translocation and iPLA(2) activation. Phosphatidylcholines 96-115 phospholipase A2 group IVA Bos taurus 201-208 15310557-1 2004 C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. Phosphatidylcholines 61-80 C-reactive protein Bos taurus 0-18 15310557-1 2004 C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. Phosphatidylcholines 61-80 C-reactive protein Bos taurus 20-23 15310557-1 2004 C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. Phosphatidylcholines 61-80 pulmonary surfactant-associated protein A Bos taurus 29-49 15310557-1 2004 C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. Phosphatidylcholines 61-80 pulmonary surfactant-associated protein A Bos taurus 51-55 15310557-9 2004 These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films. Phosphatidylcholines 60-62 pulmonary surfactant-associated protein A Bos taurus 37-41 15310557-9 2004 These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films. Phosphatidylcholines 60-62 C-reactive protein Bos taurus 46-49 15466370-1 2004 The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected. Phosphatidylcholines 158-177 lecithin-cholesterol acyltransferase Homo sapiens 74-78 15466370-1 2004 The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected. Phosphatidylcholines 179-181 lecithin-cholesterol acyltransferase Homo sapiens 74-78 15466370-2 2004 To explain these discrepancies, we proposed that LCAT transfers some saturated fatty acids from the sn-1 position of PC species that contain 20:4 or 22:6 at sn-2. Phosphatidylcholines 117-119 lecithin-cholesterol acyltransferase Homo sapiens 49-53 16127297-0 2005 Anionic peptide factor/phosphatidylcholine particles promote the inhibition of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells. Phosphatidylcholines 23-42 vascular cell adhesion molecule 1 Homo sapiens 79-112 16127297-5 2005 METHODS: We examined the effects of two HDL apolipoproteins A-I and APF, either in presence or absence of phosphatidylcholines (PCs), or free PCs, on the expression of VCAM-1 by HUVEC. Phosphatidylcholines 106-126 vascular cell adhesion molecule 1 Homo sapiens 168-174 15522822-0 2004 Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha. Phosphatidylcholines 85-104 phosphatidylinositol transfer protein alpha Homo sapiens 108-151 15522822-1 2004 Mammalian phosphatidylinositol transfer protein alpha (PITP) is an intracellular lipid transporter with a binding site that can accommodate a single molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC). Phosphatidylcholines 190-209 phosphatidylinositol transfer protein alpha Homo sapiens 10-53 15522822-1 2004 Mammalian phosphatidylinositol transfer protein alpha (PITP) is an intracellular lipid transporter with a binding site that can accommodate a single molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC). Phosphatidylcholines 211-213 phosphatidylinositol transfer protein alpha Homo sapiens 10-53 15522822-5 2004 Lipids extracted from the PITPalpha were analysed by tandem electrospray ionisation mass spectrometry (ESI-MS) and showed total exchange of acquired bacterial lipids for HL60 cellular PI and PC. Phosphatidylcholines 191-193 phosphatidylinositol transfer protein alpha Homo sapiens 26-35 15331603-1 2004 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. Phosphatidylcholines 125-144 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 15322105-8 2004 Phosphorylated PITPalpha was unable to deliver its PI cargo, although it could deliver phosphatidylcholine. Phosphatidylcholines 87-106 phosphatidylinositol transfer protein alpha Homo sapiens 15-24 15522832-7 2004 PtdEtn formed by Psd2p is the preferred substrate for PtdCho synthesis. Phosphatidylcholines 54-60 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 17-22 15331603-1 2004 CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. Phosphatidylcholines 125-144 cut-like homeobox 1 Mus musculus 81-84 15331603-2 2004 Hepatic cells express both an alpha and a beta2 isoform of CT and can also synthesize phosphatidylcholine via the sequential methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 86-105 histocompatibility 2, O region beta locus Mus musculus 40-47 15331603-6 2004 The plasma phosphatidylcholine concentration was reduced in the CTalpha knockout (independent of gender), as were levels of high density lipoproteins (cholesterol and apoAI) and very low density lipoproteins (triacylglycerols and apoB100). Phosphatidylcholines 11-30 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 64-71 15294901-3 2004 Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 94-113 phospholipase A2, group XV Mus musculus 28-54 15481031-2 2004 We have used atomic force microscopy (AFM) to study the interaction of synapsin I with negatively charged lipid domains in phase-separated supported lipid bilayers prepared from mixtures of phosphatidylcholines (PCs) and phosphatidylserines (PSs). Phosphatidylcholines 190-210 synapsin I Homo sapiens 71-81 15560781-3 2004 The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis). Phosphatidylcholines 102-121 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 15560781-3 2004 The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis). Phosphatidylcholines 123-129 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 15560781-3 2004 The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis). Phosphatidylcholines 331-337 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 15308634-0 2004 Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. Phosphatidylcholines 214-233 glutathione peroxidase 4 Homo sapiens 18-67 15308634-0 2004 Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. Phosphatidylcholines 214-233 matrix metallopeptidase 1 Homo sapiens 169-195 15466483-2 2004 Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane. Phosphatidylcholines 188-207 X-box binding protein 1 Homo sapiens 44-48 15466483-2 2004 Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane. Phosphatidylcholines 188-207 X-box binding protein 1 Homo sapiens 76-80 15466483-2 2004 Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane. Phosphatidylcholines 188-207 X-box binding protein 1 Homo sapiens 76-80 15466483-3 2004 Cells overexpressing XBP1(S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the cytidine diphosphocholine pathway of phosphatidylcholine biosynthesis. Phosphatidylcholines 193-212 X-box binding protein 1 Homo sapiens 21-25 15294901-3 2004 Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 94-113 phospholipase A2, group XV Mus musculus 63-68 15306175-1 2004 We have previously shown that intravenous apolipoprotein (apo) A-I/phosphatidylcholine (apo A-I/PC) discs increase plasma high-density lipoprotein (HDL) concentration in humans. Phosphatidylcholines 67-86 apolipoprotein A1 Homo sapiens 88-93 15752119-0 2004 Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 112-133 15752119-0 2004 Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 135-140 15342124-0 2004 Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells. Phosphatidylcholines 77-96 scavenger receptor class B member 1 Cricetulus griseus 0-34 15342124-2 2004 In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins. Phosphatidylcholines 75-94 scavenger receptor class B member 1 Cricetulus griseus 45-50 15342124-2 2004 In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins. Phosphatidylcholines 96-98 scavenger receptor class B member 1 Cricetulus griseus 45-50 15450473-3 2004 In adult lung, PTHrP stimulates disaturated phosphatidylcholine secretion, inhibits type II cell growth, and sensitizes them to apoptosis. Phosphatidylcholines 44-63 parathyroid hormone like hormone Homo sapiens 15-20 15306175-0 2004 Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid. Phosphatidylcholines 42-61 paraoxonase 1 Homo sapiens 71-82 15306175-0 2004 Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid. Phosphatidylcholines 42-61 phospholipase A2 group VII Homo sapiens 87-129 15139854-2 2004 Sphingosine decreased phosphatidylcholine synthesis by inhibiting CCT activity in primary alveolar type II epithelia. Phosphatidylcholines 22-41 t-complex protein 1 Mus musculus 66-69 15280390-0 2004 Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. Phosphatidylcholines 42-61 scavenger receptor class B member 1 Homo sapiens 114-148 15258199-0 2004 Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. Phosphatidylcholines 63-65 peroxisome proliferator activated receptor alpha Homo sapiens 84-93 15258199-0 2004 Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. Phosphatidylcholines 63-65 ATP binding cassette subfamily B member 4 Homo sapiens 121-126 15258199-8 2004 These findings suggest that BF may enhance the capacity of human hepatocytes to direct PC into bile canaliculi via PPARalpha-mediated redistribution of ABCB4 to the canalicular membrane. Phosphatidylcholines 87-89 peroxisome proliferator activated receptor alpha Homo sapiens 115-124 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. Phosphatidylcholines 81-83 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 216-221 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. Phosphatidylcholines 81-83 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 226-231 15139854-1 2004 We examined the effects of the bioactive lipid, sphingosine, on the expression of the rate-limiting enzyme involved in surfactant phosphatidylcholine synthesis, CCTalpha (CTP:phosphocholine cytidylyltransferase alpha). Phosphatidylcholines 130-149 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 171-216 15210848-3 2004 Stable overexpression of CCTalpha in lung epithelial cell lines increased rates of PC synthesis and cellular DSPC mass without altering total cellular PC content. Phosphatidylcholines 83-85 phosphate cytidylyltransferase 1A, choline Homo sapiens 25-33 15355352-7 2004 Phosphatidylethanolamine and phosphatidic acid were shown to be also hydrolysed by AtLCAT3, although less efficiently than phosphatidylcholine. Phosphatidylcholines 123-142 lecithin:cholesterol acyltransferase 3 Arabidopsis thaliana 83-90 15210848-3 2004 Stable overexpression of CCTalpha in lung epithelial cell lines increased rates of PC synthesis and cellular DSPC mass without altering total cellular PC content. Phosphatidylcholines 111-113 phosphate cytidylyltransferase 1A, choline Homo sapiens 25-33 15450206-8 2004 Phosphatidylcholine, phosphatidylethanolamine, and LPE plasmalogen (LPEP), but not choline, also activated TGF-beta1. Phosphatidylcholines 0-19 transforming growth factor, beta 1 Rattus norvegicus 107-116 15175345-3 2004 In the present paper, we optimized two independent assays for the translocation of natural phosphatidylcholine (PC) to the cell surface based on the hydrolysis of outer leaflet phosphoglycerolipids by exogenous phospholipase A2 and the exchange of outer leaflet PC by a transfer protein. Phosphatidylcholines 91-110 phospholipase A2 group IB Homo sapiens 211-227 15175345-3 2004 In the present paper, we optimized two independent assays for the translocation of natural phosphatidylcholine (PC) to the cell surface based on the hydrolysis of outer leaflet phosphoglycerolipids by exogenous phospholipase A2 and the exchange of outer leaflet PC by a transfer protein. Phosphatidylcholines 112-114 phospholipase A2 group IB Homo sapiens 211-227 15298909-2 2004 We used a well-characterized peptide corresponding to the basic effector domain of myristoylated alanine-rich C kinase substrate, MARCKS(151-175), that was fluorescently labeled with Alexa488, and measured its binding to large unilamellar vesicles (diameter approximately 100 nm) composed of phosphatidylcholine and phosphatidylserine or phosphatidylinositol 4,5-bisphosphate. Phosphatidylcholines 292-311 myristoylated alanine rich protein kinase C substrate Homo sapiens 130-136 15249196-0 2004 p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. Phosphatidylcholines 67-86 interferon induced protein 44 Homo sapiens 0-3 15249196-0 2004 p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. Phosphatidylcholines 67-86 mitogen-activated protein kinase 3 Homo sapiens 7-13 15249196-0 2004 p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 24-27 15670660-11 2004 The endotoxin-stimulated tumor necrosis factor-alpha release is decreased by dilinoleoylphosphatidylcholine, the active phosphatidylcholine (PC) species of polyenylphosphatidylcholine (PPC). Phosphatidylcholines 88-107 tumor necrosis factor Homo sapiens 25-52 15670660-11 2004 The endotoxin-stimulated tumor necrosis factor-alpha release is decreased by dilinoleoylphosphatidylcholine, the active phosphatidylcholine (PC) species of polyenylphosphatidylcholine (PPC). Phosphatidylcholines 141-143 tumor necrosis factor Homo sapiens 25-52 15130088-1 2004 PtdSer (phosphatidylserine) synthesis in mammalian cells occurs through the exchange of L-serine with the base moieties of phosphatidylcholine and phosphatidylethanolamine, which is catalysed by PSS (PtdSer synthase) 1 and 2 respectively. Phosphatidylcholines 123-142 phosphatidylserine synthase 1 Homo sapiens 200-224 15242816-3 2004 We found that addition of phosphatidylcholine-specific phospholipase D (PLD) stabilized CYP3A in this system, but that phosphatidylinositol-specific phospholipase C (PLC) was without effect. Phosphatidylcholines 26-45 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 88-93 15255942-3 2004 In this study, we investigated whether inhibition by ethanol of this signal transduction pathway in 1321N1 human astrocytoma cells may be due, at least in part, to inhibition of the formation of the PKC zeta activator phosphatidic acid (PA), which is formed by hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 275-294 protein kinase C zeta Homo sapiens 199-207 15272209-5 2004 Long-term pretreatment with NE or CT-1 increased the incorporation of (3)H-myristic acid into PC, which was blocked by atenolol. Phosphatidylcholines 94-96 cardiotrophin 1 Rattus norvegicus 34-38 15236176-5 2004 The gastric injury induced by aspirin/HCl in cyclooxygenase-1 knockout mice could be prevented if the animals were treated with phosphatidylcholine-associated aspirin. Phosphatidylcholines 128-147 prostaglandin-endoperoxide synthase 1 Mus musculus 45-61 15238222-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline. Phosphatidylcholines 81-100 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 0-39 15238222-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline. Phosphatidylcholines 81-100 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 41-44 15238222-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline. Phosphatidylcholines 102-104 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 0-39 15238222-1 2004 CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline. Phosphatidylcholines 102-104 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 41-44 15225629-0 2004 The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. Phosphatidylcholines 84-103 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 125-130 15225629-0 2004 The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. Phosphatidylcholines 84-103 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 135-140 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. Phosphatidylcholines 180-199 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 47-52 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. Phosphatidylcholines 180-199 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 57-62 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. Phosphatidylcholines 201-203 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 47-52 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. Phosphatidylcholines 201-203 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 57-62 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. Phosphatidylcholines 37-39 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 131-136 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. Phosphatidylcholines 37-39 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 141-146 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. Phosphatidylcholines 116-118 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 131-136 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. Phosphatidylcholines 116-118 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 141-146 15220446-2 2004 We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine. Phosphatidylcholines 125-144 phospholipase A2 group IB Homo sapiens 21-37 15220446-2 2004 We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine. Phosphatidylcholines 125-144 phospholipase A2 group IB Homo sapiens 39-43 15024002-9 2004 Rather, there was a trend toward increased phosphatidylcholine synthesis that might be explained by enhanced CTP:phosphocholine cytidylyltransferase activity. Phosphatidylcholines 43-62 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 109-148 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 48-64 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 66-70 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. Phosphatidylcholines 30-33 phospholipase A2 group IB Homo sapiens 48-64 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. Phosphatidylcholines 30-33 phospholipase A2 group IB Homo sapiens 66-70 15455713-0 2004 [Bromoacyl analogues of phosphatidylcholine with intramolecular fluorescence quenching and their use as substrates for continuous monitoring of phospholipase A2 activity]. Phosphatidylcholines 24-43 phospholipase A2 group IB Homo sapiens 144-160 15231944-3 2004 After the first case, we hypothesized that abnormally high BA levels could have reversed the action of phospholipase A2 in the lungs, causing a degradation of phosphatidylcholines to lysophosphatidylcholines and the consequent lack of surfactant activity, leading to the severe respiratory distress. Phosphatidylcholines 159-179 phospholipase A2 group IB Homo sapiens 103-119 15044461-0 2004 Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. Phosphatidylcholines 59-78 patatin like phospholipase domain containing 6 Homo sapiens 0-26 15246991-4 2004 CDP-choline is a well-known intermediate in the biosynthesis of phosphatidylcholine, a phospholipid essential for neuronal membrane preservation and function; thus, this compound would attenuate the process of neuronal aging. Phosphatidylcholines 64-83 cut-like homeobox 1 Mus musculus 0-3 15079868-10 2004 These data indicate that PtdCho synthesis is impaired after brain ischemia, and CDP-choline may increase PtdCho levels by attenuating the loss of CCT activity and lyso-PtdCho formation. Phosphatidylcholines 105-111 cut like homeobox 1 Homo sapiens 80-83 15020600-2 2004 Using a series of deletion mutants lacking different regions along the molecule, we examined the contribution of alpha-helix formation in apoA-I to the binding to egg phosphatidylcholine (PC) small unilamellar vesicles (SUV). Phosphatidylcholines 167-186 apolipoprotein A1 Homo sapiens 138-144 14996830-1 2004 Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC), a bacterial model for the catalytic domain of mammalian PI-PLC enzymes, was cross-linked by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride to probe for the aggregation and/or conformational changes of PI-PLC when bound to activating phosphatidylcholine (PC) interfaces. Phosphatidylcholines 325-344 phospholipase C beta 1 Homo sapiens 23-68 14996830-1 2004 Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC), a bacterial model for the catalytic domain of mammalian PI-PLC enzymes, was cross-linked by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride to probe for the aggregation and/or conformational changes of PI-PLC when bound to activating phosphatidylcholine (PC) interfaces. Phosphatidylcholines 325-344 phospholipase C beta 1 Homo sapiens 70-76 15165145-7 2004 The compound showed high reactivity with 1,1-diphenyl-2-picryl hydrazyl (DPPH), IC(50) of 84.0 +/- 7.8 microM, inhibited myeloperoxidase activity with K(0.5) = 86 +/- 9.9 microM, and decreased lipid peroxidation, induced by ascorbyl radical either in microsomes or in asolectin and phosphatidylcholine liposomes, with IC(50)"s of 320 +/- 14.1, 223 +/- 8.3, and 112 +/- 8.8 microM, respectively. Phosphatidylcholines 282-301 myeloperoxidase Rattus norvegicus 121-136 14996830-0 2004 Cross-linking phosphatidylinositol-specific phospholipase C traps two activating phosphatidylcholine molecules on the enzyme. Phosphatidylcholines 81-100 phospholipase C beta 1 Homo sapiens 14-59 14751545-3 2004 Tyrosine kinase inhibitor (genistein), phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D-609) and PKC inhibitor (GF109203X) attenuated TNF-alpha-induced COX-2 expression and PGE2 synthesis in HTSMCs. Phosphatidylcholines 39-58 tumor necrosis factor Homo sapiens 152-161 15079868-1 2004 Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia. Phosphatidylcholines 97-116 cut like homeobox 1 Homo sapiens 30-33 15079868-1 2004 Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia. Phosphatidylcholines 118-124 cut like homeobox 1 Homo sapiens 30-33 15079868-3 2004 Phospholipase A(2) (PLA(2)) hydrolyzes PtdCho to produce free fatty acids and lyso-PtdCho, an inhibitor of CCT. Phosphatidylcholines 39-45 phospholipase A2 group IB Homo sapiens 0-18 15079868-3 2004 Phospholipase A(2) (PLA(2)) hydrolyzes PtdCho to produce free fatty acids and lyso-PtdCho, an inhibitor of CCT. Phosphatidylcholines 39-45 phospholipase A2 group IB Homo sapiens 20-26 14976195-7 2004 WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide. Phosphatidylcholines 201-220 sphingomyelin synthase 1 Mus musculus 33-37 15003397-1 2004 Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+). Phosphatidylcholines 116-135 cut like homeobox 1 Homo sapiens 72-75 15003397-1 2004 Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+). Phosphatidylcholines 137-139 cut like homeobox 1 Homo sapiens 72-75 14761980-9 2004 Concentrations of ATPe effective in inducing cell death also increase phosphatidylcholine-hydrolyzing phospholipase D (PC-PLD) activity in BALB/c thymocytes through the stimulation of P2X7R. Phosphatidylcholines 70-89 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit Mus musculus 18-22 15065867-9 2004 (v) The SP-A2 variant (1A(0)) and the coexpressed protein 1A(0)/6A(2) inhibit ATP-stimulated PC secretion from alveolar type II cells to a greater extent than SP-A1 (6A(2)), a biologic activity that was susceptible to ozone treatment. Phosphatidylcholines 93-95 surfactant protein A2 Homo sapiens 8-13 14752108-1 2004 Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change. Phosphatidylcholines 20-39 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 136-168 14752108-1 2004 Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change. Phosphatidylcholines 20-39 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 170-175 14752108-1 2004 Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change. Phosphatidylcholines 41-43 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 136-168 14752108-1 2004 Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change. Phosphatidylcholines 41-43 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 170-175 14752108-2 2004 The physical properties of PC membranes containing PA are also substantially altered upon incorporation of the nAChR. Phosphatidylcholines 27-29 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 111-116 14752108-6 2004 These results show that a net negative charge alone is not sufficient to account for the unique interactions that occur between the nAChR and PC/PA membranes. Phosphatidylcholines 142-144 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 132-137 14962950-2 2004 Group V sPLA2 is expressed in cultured macrophage cells and has high affinity for phosphatidyl choline-containing substrates. Phosphatidylcholines 82-102 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 8-13 15294123-4 2004 Elastase and myeloperoxidase (MPO) release was measured for the parameters of neutrophil activation, neutrophil PLD activity was determined by quantitation of choline produced from the stable product of phosphatidylcholine catalyzed by PLD. Phosphatidylcholines 203-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 14729861-6 2004 Prebeta LpA-I contained one to four molecules of phosphatidylcholine per molecule of apoA-I, whereas LFA-I contained less than one. Phosphatidylcholines 49-68 apolipoprotein A-I Mus musculus 85-91 14754909-3 2004 Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P < 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P < 0.0001). Phosphatidylcholines 70-89 selectin P ligand Homo sapiens 126-129 14697697-0 2004 Excluded volume effect of rat intestinal mucin on taurocholate/phosphatidylcholine mixed micelles. Phosphatidylcholines 63-82 solute carrier family 13 member 2 Rattus norvegicus 41-46 15049706-5 2004 Sedimentation assays using mixed phosphatidylserine/phosphatidylcholine (PS/PC) vesicles confirmed that the C2C domains of tricalbin 1 and 3 bind membranes in a calcium-responsive manner and showed that they are more sensitive to calcium than the C2A domain of synaptotagmin I. Phosphatidylcholines 52-71 tricalbin Saccharomyces cerevisiae S288C 123-132 14754909-3 2004 Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P < 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P < 0.0001). Phosphatidylcholines 70-89 selectin P ligand Homo sapiens 103-106 14754909-3 2004 Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P < 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P < 0.0001). Phosphatidylcholines 70-89 selectin P ligand Homo sapiens 126-129 14754909-3 2004 Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P < 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P < 0.0001). Phosphatidylcholines 70-89 selectin P ligand Homo sapiens 126-129 15023079-3 2004 In the present study, PWR has been used to monitor the incorporation of the human beta(2)-adrenergic receptor into a solid-supported egg phosphatidylcholine lipid bilayer and to follow the binding of full agonists (isoproterenol, epinephrine), a partial agonist (dobutamine), an antagonist (alprenolol), and an inverse agonist (ICI-118,551) to the receptor. Phosphatidylcholines 137-156 adrenoceptor beta 2 Homo sapiens 82-109 14976195-7 2004 WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide. Phosphatidylcholines 201-220 sphingomyelin synthase 1 Mus musculus 50-58 14757231-0 2004 Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1. Phosphatidylcholines 21-40 ATP binding cassette subfamily C member 1 Homo sapiens 116-120 14962392-1 2004 Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. Phosphatidylcholines 134-153 phosphatidylinositol transfer protein alpha Homo sapiens 0-43 14962392-1 2004 Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. Phosphatidylcholines 134-153 phosphatidylinositol transfer protein alpha Homo sapiens 45-54 14962392-1 2004 Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. Phosphatidylcholines 155-157 phosphatidylinositol transfer protein alpha Homo sapiens 0-43 14962392-1 2004 Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. Phosphatidylcholines 155-157 phosphatidylinositol transfer protein alpha Homo sapiens 45-54 14755582-0 2004 Exploring the interaction of the surfactant N-terminal domain of gamma-Zein with soybean phosphatidylcholine liposomes. Phosphatidylcholines 89-108 prolamin 50 kDa gamma zein Zea mays 65-75 14985460-4 2004 Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 77-79 choline phosphotransferase 1 Homo sapiens 0-25 14985460-4 2004 Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 77-79 choline phosphotransferase 1 Homo sapiens 27-30 14985460-4 2004 Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 135-137 choline phosphotransferase 1 Homo sapiens 0-25 14985460-4 2004 Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 135-137 choline phosphotransferase 1 Homo sapiens 27-30 14757231-1 2004 Multidrug resistance-associated protein (MRP1) may function as a floppase in human red blood cells to translocate phosphatidylserine and/or phosphatidylcholine from inner membrane leaflet to outer leaflet. Phosphatidylcholines 140-159 ATP binding cassette subfamily C member 1 Homo sapiens 0-45 14757231-2 2004 Here we report that the purified and reconstituted MRP1 protein into asolectin proteoliposomes is mainly in an inside-out configuration and possesses the ability to flop a fluorescent labeled phosphatidylcholine (NBD-PC) from outer leaflet (protoplasmic) to inner leaflet (extracytoplasmic). Phosphatidylcholines 192-211 ATP binding cassette subfamily C member 1 Homo sapiens 51-55 14592540-0 2004 Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells. Phosphatidylcholines 33-52 cut like homeobox 1 Homo sapiens 120-123 14698037-10 2004 All together, the present results demonstrated that COX-2-mediated PGD(2) synthesis is a PC biosynthesis regulator in rat renal papilla. Phosphatidylcholines 89-91 cytochrome c oxidase II, mitochondrial Rattus norvegicus 52-57 15844632-1 2004 Lysophosphatidylcholine (lysoPC) is generated by the action of phospholipase A2 on membrane phosphatidylcholine, the most abundant cellular phospholipid. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 63-79 14698037-0 2004 COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. Phosphatidylcholines 40-59 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-5 14698037-5 2004 PC synthesis was highly sensitive to COX-2 inhibition, while COX-1 inhibition only reduced PC synthesis at high SC-560 concentration. Phosphatidylcholines 0-2 cytochrome c oxidase II, mitochondrial Rattus norvegicus 37-42 14698037-5 2004 PC synthesis was highly sensitive to COX-2 inhibition, while COX-1 inhibition only reduced PC synthesis at high SC-560 concentration. Phosphatidylcholines 91-93 cytochrome c oxidase I, mitochondrial Rattus norvegicus 61-66 14698037-7 2004 The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition. Phosphatidylcholines 18-20 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 88-127 14698037-7 2004 The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition. Phosphatidylcholines 18-20 cut-like homeobox 1 Rattus norvegicus 147-150 14698037-7 2004 The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition. Phosphatidylcholines 18-20 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 88-91 15218538-5 2004 These are guanidinoacetate methyltransferase (that produces creatine) and phosphatidylethanolamine N-methyltransferase (that produces phosphatidylcholine). Phosphatidylcholines 134-153 phosphatidylethanolamine N-methyltransferase Homo sapiens 74-118 15319526-4 2004 Here we show that the cation-over-anion selectivity of reconstituted ICln channels can be varied by the thickness of a bilayer build of phosphatidylcholines. Phosphatidylcholines 136-156 chloride nucleotide-sensitive channel 1A pseudogene 1 Homo sapiens 69-73 14592540-1 2004 We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 194-213 cut like homeobox 1 Homo sapiens 223-226 14592540-1 2004 We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 68-70 cut like homeobox 1 Homo sapiens 223-226 14592540-7 2004 These results constitute the first experimental evidence that the inhibition of the synthesis of PC via CDP-choline by HePC is not counterbalanced by any increase in its formation via methylation. Phosphatidylcholines 97-99 cut like homeobox 1 Homo sapiens 104-107 15622860-3 2004 To exemplify the method application to the membrane studies, energy transfer from anthrylvinyl-labeled phosphatidylcholine incorporated into mixed phosphatidylcholine/cardiolipin unilamellar vesicles to heme group of cytochrome c is analyzed. Phosphatidylcholines 103-122 cytochrome c, somatic Homo sapiens 217-229 15669680-5 2004 In the Hexb mouse, a model of Sandhoff disease, lipid phosphate levels were elevated in surfactant from 3- and 4-month-old mice, which was mainly due to elevated levels of phosphatidylcholine. Phosphatidylcholines 172-191 hexosaminidase B Mus musculus 7-11 15669680-6 2004 In the ASM mouse, a model of Niemann-Pick A disease, levels of the primary storage material, sphingomyelin, were elevated as expected, and levels of phosphatidylcholine and two other phospholipids were also significantly elevated in pulmonary surfactant and in lung tissue from 5-, 6- and 7-month-old mice. Phosphatidylcholines 149-168 sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus 7-10 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14675982-2 2004 In Group A (oestrogen alone) HDL2 phosphatidylcholine increased (P<0.001), while there was a decrease in HDL2 phosphatidylinositol (P<0.05) and HDL2 phosphatidylethanolamine (P<0.05) compared to controls (baseline). Phosphatidylcholines 34-53 junctophilin 3 Homo sapiens 29-33 14675982-3 2004 In the same group, HDL3 phosphatidylcholine increased (P<0.001) and HDL3 phosphatidylethanolamine decreased (P<0.01). Phosphatidylcholines 24-43 HDL3 Homo sapiens 19-23 14675982-4 2004 In Group B (raloxifene) HDL2 phosphatidylcholine increased (P<0.001) as well as HDL2 diphosphatidylglycerol (P<0.01) while there were decreases in HDL2 sphingomyelin (P<0.01) and HDL2 phosphatidylethanolamine (P<0.05). Phosphatidylcholines 29-48 junctophilin 3 Homo sapiens 24-28 15173620-3 2004 The assay for cPLA2alpha involves measuring the calcium-dependent release of radiolabeled sn-2 arachidonic acid from small unilamellar vesicles of phosphatidylcholine. Phosphatidylcholines 147-166 phospholipase A2 group IVA Homo sapiens 14-24 14675982-5 2004 In the same group, an increase in HDL3 phosphatidylcholine (P<0.001) and a reduction in HDL3 phosphatidylinositol (P<0.05) were observed as well as a decrease in HDL3 phosphatidylethanolamine (P<0.01) and HDL3 diphosphatidylglycerol (P<0.05). Phosphatidylcholines 39-58 HDL3 Homo sapiens 34-38 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14528019-2 2004 Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. Phosphatidylcholines 152-171 phospholipase D Saccharomyces cerevisiae S288C 37-43 14528019-2 2004 Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. Phosphatidylcholines 152-171 phospholipase D Saccharomyces cerevisiae S288C 112-127 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 14528019-2 2004 Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. Phosphatidylcholines 173-179 phospholipase D Saccharomyces cerevisiae S288C 37-43 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 28-33 14528019-2 2004 Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. Phosphatidylcholines 173-179 phospholipase D Saccharomyces cerevisiae S288C 112-127 15517554-1 2004 Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS). Phosphatidylcholines 60-79 protocadherin 8 Homo sapiens 54-58 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 35-39 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 28-33 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 35-39 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-100 choline phosphotransferase 1 Homo sapiens 0-25 14557258-1 2003 Lipoprotein(a), Lp(a), an athero-thrombotic risk factor, reacts with EO6, a natural monoclonal autoantibody that recognizes the phophorylcholine (PC) group of oxidized phosphatidylcholine (oxPtdPC) either as a lipid or linked by a Schiff base to lysine residues of peptides/proteins. Phosphatidylcholines 168-187 lipoprotein(a) Homo sapiens 16-21 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 102-104 choline phosphotransferase 1 Homo sapiens 0-25 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 102-104 choline phosphotransferase 1 Homo sapiens 27-30 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 161-163 choline phosphotransferase 1 Homo sapiens 0-25 14557275-4 2003 Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids. Phosphatidylcholines 40-59 diacylglycerol O-acyltransferase 1 Homo sapiens 131-135 14557275-4 2003 Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids. Phosphatidylcholines 40-59 diacylglycerol O-acyltransferase 1 Homo sapiens 182-186 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 161-163 choline phosphotransferase 1 Homo sapiens 27-30 14651986-1 2003 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-100 choline phosphotransferase 1 Homo sapiens 27-30 14597574-0 2003 Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis. Phosphatidylcholines 8-27 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 0-4 14729069-1 2003 Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho). Phosphatidylcholines 168-187 phosphatidylinositol transfer protein alpha Homo sapiens 0-43 14729069-1 2003 Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho). Phosphatidylcholines 168-187 phosphatidylinositol transfer protein alpha Homo sapiens 45-55 14729069-1 2003 Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho). Phosphatidylcholines 189-195 phosphatidylinositol transfer protein alpha Homo sapiens 0-43 14729069-1 2003 Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho). Phosphatidylcholines 189-195 phosphatidylinositol transfer protein alpha Homo sapiens 45-55 14729069-3 2003 In this study, polar lipid metabolites of PtdIns and PtdCho were tested for their ability to influence PITP-alpha activity. Phosphatidylcholines 53-59 phosphatidylinositol transfer protein alpha Homo sapiens 103-113 14729069-4 2003 GroPCho inhibited the ability of PITP-alpha to transfer PtdIns or PtdCho between liposomes. Phosphatidylcholines 66-72 phosphatidylinositol transfer protein alpha Homo sapiens 33-43 14729070-3 2003 When platelets were preesterified with either 25 microM 9t, 11t-CLA or 9c, 11c-CLA, CLA incorporation in total platelet lipids increased from 0.24% to 0.31% and 0.38%, and most of this increase was found to be in the phosphatidyl choline and phosphatidyl ethanolamine subclasses. Phosphatidylcholines 217-237 olfactory receptor family 1 subfamily L member 1 Homo sapiens 68-73 14514684-7 2003 Moreover, we demonstrate for the first time that phosphatidylcholine and phosphatidylethanolamine, which are the main components of the mitochondrial outer membrane, are potent activators of both enzymatic activities of CoA synthase in vitro. Phosphatidylcholines 49-68 Coenzyme A synthase Homo sapiens 220-232 14597574-3 2003 Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine. Phosphatidylcholines 212-231 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 80-120 14597574-3 2003 Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine. Phosphatidylcholines 212-231 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 122-125 12928431-3 2003 We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 24-26 nerve growth factor Rattus norvegicus 35-54 14636062-0 2003 Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains. Phosphatidylcholines 134-153 lecithin-cholesterol acyltransferase Homo sapiens 92-129 14636062-1 2003 We previously described a point mutation in human LCAT (E to A at residue 149; hE149A) that demonstrated greater activity with phosphatidylcholine (PC) substrate containing 20:4 in the sn-2 position compared with the wild-type enzyme [hLCAT; Wang et al. Phosphatidylcholines 127-146 lecithin-cholesterol acyltransferase Homo sapiens 50-54 14636062-1 2003 We previously described a point mutation in human LCAT (E to A at residue 149; hE149A) that demonstrated greater activity with phosphatidylcholine (PC) substrate containing 20:4 in the sn-2 position compared with the wild-type enzyme [hLCAT; Wang et al. Phosphatidylcholines 148-150 lecithin-cholesterol acyltransferase Homo sapiens 50-54 14636062-7 2003 In the second experiment, we found that hE149A compared with hLCAT demonstrated higher activity with PC species containing 20-carbon, but not 18-carbon, sn-2 fatty acyl chains. Phosphatidylcholines 101-103 lecithin-cholesterol acyltransferase Homo sapiens 61-66 14636062-9 2003 Substitution of different amino acids in the 149 position of hLCAT showed that activation of the enzyme with sn-2 20:4 containing PC substrate was only observed when the negative charge at residue 149 was removed. Phosphatidylcholines 130-132 lecithin-cholesterol acyltransferase Homo sapiens 61-66 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 311-314 12922983-2 2003 Parathyroid hormone-related protein (PTHrP) 1-34 could have a regulatory role in this process because it stimulates phosphatidylcholine secretion and inhibits type II cell growth. Phosphatidylcholines 116-135 parathyroid hormone like hormone Homo sapiens 0-35 12922983-2 2003 Parathyroid hormone-related protein (PTHrP) 1-34 could have a regulatory role in this process because it stimulates phosphatidylcholine secretion and inhibits type II cell growth. Phosphatidylcholines 116-135 parathyroid hormone like hormone Homo sapiens 37-42 12922983-6 2003 Reversing the decline in PTHrP 1-34 or PTHrP 67-86 with one intratracheal dose and four daily subcutaneous doses of PTHrP 1-34 or PTHrP 67-86 stimulated bronchoalveolar lavage disaturated phosphatidylcholine (DSPC) levels. Phosphatidylcholines 188-207 parathyroid hormone like hormone Homo sapiens 25-30 14596606-10 2003 Alpha-synuclein exhibits a selectivity of interaction with different phospholipid spin labels when bound to phosphatidylglycerol membranes in the following order: stearic acid > cardiolipin > phosphatidylcholine > phosphatidylglycerol approximately phosphatidylethanolamine > phosphatidic acid approximately phosphatidylserine > N-acyl phosphatidylethanolamine > diglyceride. Phosphatidylcholines 198-217 synuclein alpha Homo sapiens 0-15 12928431-3 2003 We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 24-26 nerve growth factor Rattus norvegicus 56-59 12928431-3 2003 We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 24-26 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 155-194 14580712-0 2003 Linkage identity is a major factor in determining the effect of PEG-ylated surfactants on permeability of phosphatidylcholine liposomes. Phosphatidylcholines 106-125 progestagen associated endometrial protein Homo sapiens 64-67 12913002-7 2003 The appearance of this surface suggests a putative binding region for membrane-derived SP-A ligands such as phosphatidylcholine and lipid A, the endotoxic lipid component of bacterial lipopolysaccharide that mediates the potentially lethal effects of Gram-negative bacterial infection. Phosphatidylcholines 108-127 surfactant protein A1 Homo sapiens 87-91 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 114-133 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 114-133 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 135-137 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 135-137 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 188-190 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. Phosphatidylcholines 188-190 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 14608048-2 2003 Mice with a homozygous disruption of the PEMT gene are dependent on the 1,2-diacylglycerol cholinephosphotransferase (CDP-choline) pathway for the synthesis of PC and develop severe liver steatosis when fed a diet deficient in choline. Phosphatidylcholines 160-162 phosphatidylethanolamine N-methyltransferase Mus musculus 41-45 14608048-2 2003 Mice with a homozygous disruption of the PEMT gene are dependent on the 1,2-diacylglycerol cholinephosphotransferase (CDP-choline) pathway for the synthesis of PC and develop severe liver steatosis when fed a diet deficient in choline. Phosphatidylcholines 160-162 cut-like homeobox 1 Mus musculus 118-121 12912985-1 2003 Phosphatidylserine (PtdSer) in mammalian cells is synthesized through the action of PtdSer synthase (PSS) 1 and 2, which catalyze the conversion of phosphatidylcholine and phosphatidylethanolamine, respectively, to PtdSer. Phosphatidylcholines 148-167 phosphatidylserine synthase 1 Homo sapiens 84-113 14530366-3 2003 We investigated the potential role of phosphoinositide 3-kinase (PI3K) in the activation of gIV-PLA(2) and the hydrolysis of membrane phosphatidylcholine in fMLP-stimulated human blood eosinophils. Phosphatidylcholines 134-153 formyl peptide receptor 1 Homo sapiens 157-161 14530343-0 2003 Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6. Phosphatidylcholines 0-19 signal transducer and activator of transcription 6 Homo sapiens 89-94 14530343-5 2003 We discovered that inhibitors of phosphatidylcholine-specific phospholipase C (PC-PLC), but not other lipases, blocked the activation of STAT6 by IL-4. Phosphatidylcholines 33-52 signal transducer and activator of transcription 6 Homo sapiens 137-142 14530343-5 2003 We discovered that inhibitors of phosphatidylcholine-specific phospholipase C (PC-PLC), but not other lipases, blocked the activation of STAT6 by IL-4. Phosphatidylcholines 33-52 interleukin 4 Homo sapiens 146-150 12796497-5 2003 As low a concentration as 10 nm exogenous hVPLA2 was able to elicit the significant release of AA and LTC4 from unstimulated eosinophils, which depended on its ability to act on phosphatidylcholine membranes. Phosphatidylcholines 178-197 phospholipase A2 group V Homo sapiens 42-48 14583784-5 2003 In addition, both U-73122, which inhibits agonist-induced phospholipase C (PLC) activation and D609, a specific inhibitor of phosphatidylcholine-specific PLC also inhibited PIF-induced proteasome activity. Phosphatidylcholines 125-144 Pif Mus musculus 173-176 14608048-8 2003 These findings indicate that PEMT activity functions beyond its recognized role as a compensatory pathway for PC biosynthesis and that, in contrast, PEMT activity is involved in many physiologic processes including the flux of lipid between liver and plasma and the delivery of essential fatty acids to blood and peripheral tissues via the liver-derived lipoproteins. Phosphatidylcholines 110-112 phosphatidylethanolamine N-methyltransferase Mus musculus 29-33 14664823-1 2003 Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. Phosphatidylcholines 39-58 phospholipase A2, group IB, pancreas Mus musculus 0-18 14664823-1 2003 Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. Phosphatidylcholines 39-58 phospholipase A2, group IB, pancreas Mus musculus 20-26 12915713-10 2003 The inhibition of diacylglycerol lipase partially blocked and the selective inhibition of Src kinases and phosphatidylcholine-specific phospholipase C (PC-PLC) completely blocked the inhibitory effects of the noncoplanar PCB on GJIC, indicating that PC-PLC or sphingomyelinase and Src might be upstream regulators of noncoplanar PCB-induced inhibition of GJIC. Phosphatidylcholines 106-125 pyruvate carboxylase Rattus norvegicus 221-224 12917409-4 2003 ABCA7 expression increased cellular phosphatidylcholine and sphingomyelin efflux to apoA-I in a manner similar to ABCA1 but had no effect on cholesterol efflux. Phosphatidylcholines 36-55 ATP binding cassette subfamily A member 7 Homo sapiens 0-5 12917409-4 2003 ABCA7 expression increased cellular phosphatidylcholine and sphingomyelin efflux to apoA-I in a manner similar to ABCA1 but had no effect on cholesterol efflux. Phosphatidylcholines 36-55 apolipoprotein A1 Homo sapiens 84-90 14536058-3 2003 Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels. Phosphatidylcholines 100-102 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 65-69 14536058-3 2003 Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels. Phosphatidylcholines 171-173 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 65-69 14536058-7 2003 A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. Phosphatidylcholines 23-25 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 105-110 14536058-7 2003 A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. Phosphatidylcholines 23-25 Epidermal growth factor receptor Drosophila melanogaster 116-120 14536058-7 2003 A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. Phosphatidylcholines 23-25 Notch Drosophila melanogaster 122-127 12810817-9 2003 Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile. Phosphatidylcholines 81-83 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 142-146 12857760-0 2003 Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 41-60 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 104-143 12842877-5 2003 This approach identified mutations in a single gene, YNL323W/LEM3, that conferred resistance to alkylphosphocholine drugs and inhibited internalization of NBD-labeled phosphatidylcholine. Phosphatidylcholines 167-186 Lem3p Saccharomyces cerevisiae S288C 61-65 12842877-11 2003 These data demonstrate a requirement for Lem3p expression for normal phosphatidylcholine and alkylphosphocholine drug transport across the plasma membrane of yeast. Phosphatidylcholines 69-88 Lem3p Saccharomyces cerevisiae S288C 41-46 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 0-19 cut-like homeobox 1 Mus musculus 53-56 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 81-125 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 127-131 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 21-23 cut-like homeobox 1 Mus musculus 53-56 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Mus musculus 81-125 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Mus musculus 127-131 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 196-198 phosphatidylethanolamine N-methyltransferase Mus musculus 81-125 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. Phosphatidylcholines 196-198 phosphatidylethanolamine N-methyltransferase Mus musculus 127-131 12837848-16 2003 Secretion of PEMT-derived PC into lipoproteins was examined in vivo by injection of mice with [methyl-3H]methionine in the presence of Triton WR1339. Phosphatidylcholines 26-28 phosphatidylethanolamine N-methyltransferase Mus musculus 13-17 12837848-18 2003 Secretion of PEMT-derived PC into bile was enhanced in mice fed a HF/HC diet. Phosphatidylcholines 26-28 phosphatidylethanolamine N-methyltransferase Mus musculus 13-17 12837848-19 2003 These results demonstrate that the synthesis and targeting of PC produced by the PEMT pathway in the livers of mice differs in a gender- and diet-specific manner. Phosphatidylcholines 62-64 phosphatidylethanolamine N-methyltransferase Mus musculus 81-85 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 12893687-0 2003 Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP, and CETP in plasma and peripheral lymph in humans. Phosphatidylcholines 42-61 lecithin-cholesterol acyltransferase Homo sapiens 71-75 12893687-1 2003 OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans. Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 53-71 12893687-1 2003 OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans. Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 93-102 12810817-9 2003 Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile. Phosphatidylcholines 81-83 scavenger receptor class B, member 1 Mus musculus 151-156 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 39-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12799368-10 2003 Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine. Phosphatidylcholines 235-254 histone demethylase GIS1 Saccharomyces cerevisiae S288C 41-45 12813037-4 2003 Efflux of low density lipoprotein-derived, non-lipoprotein, plasma membrane, and newly synthesized pools of cell cholesterol by apoA-I was diminished in NPC1-/- cells, as was efflux of phosphatidylcholine and sphingomyelin. Phosphatidylcholines 185-204 NPC intracellular cholesterol transporter 1 Homo sapiens 153-157 12799368-10 2003 Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine. Phosphatidylcholines 235-254 histone demethylase GIS1 Saccharomyces cerevisiae S288C 71-76 12922169-13 2003 We demonstrate, using fluorescence resonance energy transfer, that at low concentrations, NAP-22 labeled with Texas Red binds equally well to liposomes of phosphatidylcholine either with or without the addition of 40 mol% cholesterol. Phosphatidylcholines 155-174 brain abundant membrane attached signal protein 1 Homo sapiens 90-96 12865160-10 2003 Moxonidine-induced induction of MKP-2 was time- and dose-dependent and could be blocked by the I(1)-antagonist efaroxan or by D609, an inhibitor of phosphatidylcholine-selective phospholipase C known to block downstream signaling events coupled to I(1)-receptors. Phosphatidylcholines 148-167 dual specificity phosphatase 4 Rattus norvegicus 32-37 12899624-0 2003 Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined. Phosphatidylcholines 157-176 phospholipase C beta 1 Homo sapiens 118-124 12899624-0 2003 Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined. Phosphatidylcholines 178-180 phospholipase C beta 1 Homo sapiens 118-124 12837922-9 2003 Blockade of phosphatidylcholine and phosphatidyl-ethanolamine transfer by a 60 min, 56 degrees C heating step or with anti-PLTP antibody revealed that PLTP accounts for almost 80% of the phospholipid transfer activity present in seminal plasma. Phosphatidylcholines 12-31 phospholipid transfer protein Homo sapiens 151-155 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 Csr1p Saccharomyces cerevisiae S288C 82-87 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 92-97 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 phospholipase D Saccharomyces cerevisiae S288C 128-133 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 15-21 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 Csr1p Saccharomyces cerevisiae S288C 45-50 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 55-60 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 lysophospholipase Saccharomyces cerevisiae S288C 92-97 12859204-5 2003 Compared to wild-type littermates, Abca1(-/-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin (SPH) (49-fold), and phosphatidylethanolamine (PE) (18-fold) showed even higher increases. Phosphatidylcholines 75-77 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 35-40 12730219-9 2003 In contrast to oleic acid and sphingosine that exhibited inhibitory effects, phosphatidylcholine, phosphatidylserine, and phosphatidic acid stimulated MGAT2 activities. Phosphatidylcholines 77-96 mannoside acetylglucosaminyltransferase 2 Mus musculus 151-156 12818350-9 2003 Messenger RNA export rate in PLA(2) (10(-3) unit/mL)- treated nuclear membrane was positively correlated with level of PC incorporation, both using ATP and GTP as substrates. Phosphatidylcholines 119-121 phospholipase A2 group IB Rattus norvegicus 29-35 12668679-0 2003 A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. Phosphatidylcholines 80-99 phosphatidylethanolamine N-methyltransferase Mus musculus 27-71 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 interleukin 6 Homo sapiens 57-61 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 phospholipase A2 group X Homo sapiens 90-97 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 208-227 interleukin 6 Homo sapiens 62-66 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 229-231 interleukin 6 Homo sapiens 62-66 12809502-2 2003 Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers. Phosphatidylcholines 198-217 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 72-75 12809502-2 2003 Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers. Phosphatidylcholines 219-221 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 72-75 12670959-4 2003 Measurements of cross-relaxation rates in two-dimensional nuclear Overhauser enhancement spectroscopy NMR experiments show that the five Phe rings of MARCKS-(151-175) penetrate into the acyl chain region of phosphatidylcholine bilayers containing phosphatidylglycerol or PI(4,5)P2. Phosphatidylcholines 207-226 myristoylated alanine rich protein kinase C substrate Homo sapiens 150-156 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 12842190-7 2003 These data suggest unique roles for the CCT protein isoforms in the differential regulation of PtdCho biosynthesis in specific tissues. Phosphatidylcholines 95-101 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 40-43 12934648-7 2003 This enzyme hydrolyzed PAF and oxidatively modified phosphatidylcholine. Phosphatidylcholines 52-71 PCNA clamp associated factor Homo sapiens 23-26 12940517-9 2003 In order to get more reliable results, we recommend that clinicians and researchers use NBD-phosphatidylcholines as PLA2 substrates in biological samples and start with an analytical separation of reaction products followed by image analysis of the fluorescent spots. Phosphatidylcholines 92-112 phospholipase A2 group IB Homo sapiens 116-120 12865412-3 2003 KGF stimulated acetate incorporation into phosphatidylcholine, disaturated phosphatidylcholine, and phosphatidylglycerol more than 5% rat serum alone. Phosphatidylcholines 42-61 fibroblast growth factor 7 Homo sapiens 0-3 12872987-0 2003 Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide. Phosphatidylcholines 45-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-30 12872987-3 2003 LPS enhances expression of COX-2 mRNA and protein by activating sequentially phosphatidylcholine-specific phospholipase C (PC-PLC), protein kinase C (PKC) and phosphatidylcholine-specific phospholipase D (PC-PLD). Phosphatidylcholines 77-96 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 12771001-5 2003 Dose-response curves were repeated after systemic infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) disks. Phosphatidylcholines 81-100 apolipoprotein A1 Homo sapiens 102-111 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12668679-6 2003 Moreover, female and, to a lesser extent, male Pemt-/- mice showed a striking 40% decrease in plasma PC and cholesterol in high density lipoproteins. Phosphatidylcholines 101-103 phosphatidylethanolamine N-methyltransferase Mus musculus 47-51 12771334-2 2003 In this study, it inhibited human and porcine pancreatic lipase activity in substrate emulsions containing bile salts and phosphatidylcholine, in the concentration range of 10-1000 mg/L. Phosphatidylcholines 122-141 lipase G, endothelial type Rattus norvegicus 57-63 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 301-320 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 301-320 NK2 homeobox 1 Homo sapiens 155-159 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 322-324 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 322-324 NK2 homeobox 1 Homo sapiens 155-159 12962277-6 2003 Addition of a mol fraction of phosphatidylserine of 0.05 to membranes of phosphatidylcholine and cholesterol enhances the membrane binding of NAP-22. Phosphatidylcholines 73-92 brain abundant membrane attached signal protein 1 Homo sapiens 142-148 12745074-6 2003 Furthermore, indolicidin caused significant morphological changes when tested for the membrane disrupting activity using liposomes (phosphatidylcholine/cholesterol; 10:1, w/w). Phosphatidylcholines 132-151 cathelicidin-4 Bos taurus 13-24 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 113-132 cut-like homeobox 1 Rattus norvegicus 23-26 12764097-5 2003 Exposure of cortical neurons to neurotoxic concentrations of NMDA increased extracellular choline and activated hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 but did not induce significant degradation of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, or phosphatidylserine. Phosphatidylcholines 126-145 phospholipase A2 group IB Homo sapiens 174-190 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 134-136 cut-like homeobox 1 Rattus norvegicus 23-26 12695484-3 2003 We show that Anx4 exhibited binding to liposomes (phosphatidylcholine:phosphatidylserine, 1:1) in the presence of Ca2+ and binding was reversible with EDTA. Phosphatidylcholines 50-69 annexin A4 Homo sapiens 13-17 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-45 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 47-55 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 cut-like homeobox 1 Rattus norvegicus 185-188 12743757-6 2003 Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors. Phosphatidylcholines 119-138 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 76-81 12743757-6 2003 Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors. Phosphatidylcholines 119-138 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 86-91 12691414-1 2003 OBJECT: In previous studies at their laboratory the authors showed that cytidinediphosphocholine (CDP-choline), an intermediate of phosphatidylcholine synthesis, decreases edema formation and blood-brain barrier disruption following traumatic brain injury (TBI). Phosphatidylcholines 131-150 cut-like homeobox 1 Rattus norvegicus 98-101 12534371-1 2003 We investigated the kinetic behaviour and substrate specificity of PTEN (phosphatase and tensin homologue deleted on chromosome 10) using unilamellar vesicles containing substrate lipids in a background of phosphatidylcholine. Phosphatidylcholines 206-225 phosphatase and tensin homolog Homo sapiens 67-71 12659848-3 2003 In this study, using fluorescence resonance energy transfer, we found that after A beta binds to raft-like membranes composed of monosialoganglioside GM1/cholesterol/sphingomyelin (1/1/1), the protein can translocate to the phosphatidylcholine membranes to which soluble A beta does not bind. Phosphatidylcholines 224-243 amyloid beta precursor protein Homo sapiens 81-87 12761300-6 2003 These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway. Phosphatidylcholines 128-147 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 28-33 12761300-6 2003 These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway. Phosphatidylcholines 128-147 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 98-102 12633683-8 2003 The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM. Phosphatidylcholines 105-107 lipoprotein lipase Homo sapiens 26-44 12871410-6 2003 In contrast, addition of phosphatidylcholine/phosphatidylserine vesicles corrected prolonged clotting times caused by either anti-beta2GPI or antiprothrombin antibodies with LAC activity. Phosphatidylcholines 25-44 apolipoprotein H Homo sapiens 130-138 12633683-8 2003 The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM. Phosphatidylcholines 105-107 lipoprotein lipase Homo sapiens 46-49 12632206-1 2003 We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes. Phosphatidylcholines 242-244 OXA1L mitochondrial inner membrane protein Homo sapiens 99-104 12604528-2 2003 More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA(2) at 10 micro M Ca(2+) was attenuated by these peptides while augmented product formation was observed in the presence of 5 mM Ca(2+). Phosphatidylcholines 33-52 phospholipase A2 group X Homo sapiens 81-88 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 108-112 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 144-148 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 144-148 12482759-3 2003 A potential source for homocysteine is methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase in the liver. Phosphatidylcholines 92-111 phosphatidylethanolamine N-methyltransferase Mus musculus 115-159 12562848-5 2003 PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho. Phosphatidylcholines 96-102 pleckstrin and Sec7 domain containing Homo sapiens 19-24 12562848-5 2003 PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho. Phosphatidylcholines 96-102 pleckstrin and Sec7 domain containing 2 Homo sapiens 29-34 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. Phosphatidylcholines 133-152 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 8-13 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. Phosphatidylcholines 133-152 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 18-23 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). Phosphatidylcholines 74-93 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). Phosphatidylcholines 95-97 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. Phosphatidylcholines 292-294 fatty acid desaturase 2 Rattus norvegicus 37-61 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. Phosphatidylcholines 292-294 fatty acid desaturase 2 Rattus norvegicus 49-60 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 transporter 1, ATP binding cassette subfamily B member Homo sapiens 22-27 12547783-4 2003 For phosphatidylcholine spin-labeled at different positions down the sn-2 chain, the amplitude of the deuterium signal decreases toward the center of the membrane, and is reduced to zero from the C-12 atom position onward. Phosphatidylcholines 4-23 solute carrier family 38 member 5 Homo sapiens 69-73 12540796-5 2003 Cationic liposomes composed of DDAB and equimolar of a neutral lipid, egg yolk phosphatidylcholine (EPC), induced the strongest antigen-specific Th1 type immune responses among the cationic liposome investigated, whereas the liposomes composed of 2 cationic lipids, DDAB and DOEPC, induced an antigen-specific Th2 type immune response. Phosphatidylcholines 79-98 negative elongation factor complex member C/D Homo sapiens 145-148 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 transporter 2, ATP binding cassette subfamily B member Homo sapiens 29-34 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 SEC14 like lipid binding 4 Homo sapiens 39-44 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 134-140 13129817-0 2003 Apoptosis mediated by phosphatidylcholine-specific phospholipase C is associated with cAMP, p53 level, and cell-cycle distribution in vascular endothelial cells. Phosphatidylcholines 22-41 tumor protein p53 Homo sapiens 92-95 12598036-5 2003 This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains. Phosphatidylcholines 88-107 brain abundant membrane attached signal protein 1 Homo sapiens 143-149 12598036-5 2003 This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains. Phosphatidylcholines 109-111 brain abundant membrane attached signal protein 1 Homo sapiens 143-149 12359733-7 2002 A dramatic correlation exists between the ability of the sPLA(2)s to hydrolyze phosphatidylcholine-rich vesicles efficiently in vitro and the ability to release arachidonic acid when added exogenously to mammalian cells; the group V and X sPLA(2)s are uniquely efficient in this regard. Phosphatidylcholines 79-98 phospholipase A2 group IID Homo sapiens 57-65 12519189-4 2003 Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3. Phosphatidylcholines 61-80 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 95-99 12519189-4 2003 Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3. Phosphatidylcholines 61-80 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 104-108 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 12899657-2 2003 Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC). Phosphatidylcholines 19-38 insulin Homo sapiens 0-7 12899657-2 2003 Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC). Phosphatidylcholines 40-42 insulin Homo sapiens 0-7 12244093-2 2002 The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin. Phosphatidylcholines 115-134 glucosidase II alpha subunit Homo sapiens 105-110 12244093-2 2002 The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin. Phosphatidylcholines 136-138 glucosidase II alpha subunit Homo sapiens 105-110 12443983-1 2002 Citicoline, or CDP-choline, is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine that may act as a neuroprotector in several models of neurodegeneration. Phosphatidylcholines 91-110 cut like homeobox 1 Homo sapiens 15-18 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 1 Mus musculus 0-4 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 2 Mus musculus 9-13 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 1 Mus musculus 129-133 12228236-3 2002 Similarly, when apolipoprotein A-I removed cellular cholesterol, phosphatidylcholine, and sphingomyelin to generate high density lipoprotein, cholesterol synthesis from acetate subsequently increased, and sphingomyelin synthesis from acetate and serine also increased. Phosphatidylcholines 65-84 apolipoprotein A-I Mus musculus 16-34 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 41-61 phospholipase A2 group IB Homo sapiens 98-114 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 41-61 phospholipase A2 group IB Homo sapiens 116-120 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 63-65 phospholipase A2 group IB Homo sapiens 98-114 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 63-65 phospholipase A2 group IB Homo sapiens 116-120 12223447-0 2002 Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 108-147 12421918-7 2002 We found a similar frequency of phosphatidylcholine-specific CD5(+) B-1 cells in the two strains of mice. Phosphatidylcholines 32-51 CD5 antigen Mus musculus 61-64 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. Phosphatidylcholines 85-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 6-50 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. Phosphatidylcholines 85-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 52-56 12200438-2 2002 In this study, we have used both nutritional deprivation as well as a conditional temperature sensitive allele of PCT1 (CTP:phosphocholine cytidylyltransferase) coupled with an inactivated phosphatidylethanolamine methylation pathway to determine how cells respond to inactivation of phosphatidylcholine synthesis. Phosphatidylcholines 284-303 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 114-118 12200438-3 2002 Metabolic studies determined that phosphatidylcholine biosynthesis decreased to negligible levels within 1 h upon shift to the nonpermissive temperature for the temperature-sensitive PCT1 allele. Phosphatidylcholines 34-53 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 183-187 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 0-5 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 31-37 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 224-228 12408975-3 2002 The oxidation products of 1- and/or 2-oleoyl phosphatidylcholine (PC) or phosphatidylethanolamine were the most potent compounds, while those of arachidonyl PC possessed only a weak inhibitory effect on the TFPI activity. Phosphatidylcholines 66-68 tissue factor pathway inhibitor Homo sapiens 207-211 12180909-1 2002 The apoptotic protein Bax, in oligomeric form, is effective in promoting both leakage and lipid mixing in liposomes composed of cardiolipin and phosphatidylethanolamine and/or phosphatidylcholine, upon the addition of calcium. Phosphatidylcholines 176-195 BCL2 associated X, apoptosis regulator Homo sapiens 22-25 12133835-6 2002 Disruption of the ROS3 gene resulted in a marked decrease in the internalization of fluorescence-labeled analogs of PE and phosphatidylcholine, whereas the uptake of fluorescence-labeled phosphatidylserine and endocytic markers was not affected. Phosphatidylcholines 123-142 Lem3p Saccharomyces cerevisiae S288C 18-22 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat1p Saccharomyces cerevisiae S288C 140-144 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat2p Saccharomyces cerevisiae S288C 149-153 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat2p Saccharomyces cerevisiae S288C 238-242 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 129-131 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 129-131 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12512933-2 2002 Addition of the major proteolipid (PLP) to phosphatidylcholine-cholesterol vesicles caused their clustering as determined by increase in O.D. Phosphatidylcholines 43-62 proteolipid protein 1 Homo sapiens 35-38 12442901-1 2002 We investigated the possible involvement of phosphatidylcholine-specific phospholipase C (PC-PLC) in the thyroid-stimulating hormone (TSH)-induced protein kinase C (PKC)/phospholipase D (PLD) activation in FRTL-5 thyroid cells. Phosphatidylcholines 44-63 protein kinase C, alpha Rattus norvegicus 165-168 12183451-4 2002 ALP inhibited PC synthesis at the CTP:phosphocholine cytidylyltransferase (CT) step in S49 cells, but not in S49(AR) cells. Phosphatidylcholines 14-16 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 34-73 12271462-2 2002 PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho. Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 21-39 12271462-2 2002 PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho. Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 41-47 12167660-6 2002 Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation. Phosphatidylcholines 280-299 Gat1p Saccharomyces cerevisiae S288C 21-25 12167660-6 2002 Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation. Phosphatidylcholines 280-299 Gat2p Saccharomyces cerevisiae S288C 30-34 12167660-9 2002 Our results are consistent with a model whereby phosphatidic acid generated from phosphatidylcholine hydrolysis by Spo14p regulates susceptibility to choline-containing lysolipid analogs and drugs. Phosphatidylcholines 81-100 phospholipase D Saccharomyces cerevisiae S288C 115-121 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 91-110 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-83 choline phosphotransferase 1 Homo sapiens 0-25 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-83 choline phosphotransferase 1 Homo sapiens 27-30 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 139-141 choline phosphotransferase 1 Homo sapiens 0-25 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 139-141 choline phosphotransferase 1 Homo sapiens 27-30 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 236-238 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 112-114 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12244213-9 2002 These data suggest that CRP binds OxLDL and apoptotic cells by recognition of a PC moiety that becomes accessible as a result of oxidation of PtC molecule. Phosphatidylcholines 142-145 C-reactive protein Homo sapiens 24-27 12471472-2 2002 We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 60-79 phospholipase A2 group IB Homo sapiens 26-32 12471472-2 2002 We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 60-79 proprotein convertase subtilisin/kexin type 7 Homo sapiens 88-117 12471472-2 2002 We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 81-83 phospholipase A2 group IB Homo sapiens 26-32 12471472-2 2002 We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 81-83 proprotein convertase subtilisin/kexin type 7 Homo sapiens 88-117 12355253-5 2002 This is consistent with the preferential interaction between PDC-109 and phosphatidylcholine. Phosphatidylcholines 73-92 seminal plasma protein PDC-109 Bos taurus 61-68 12355253-6 2002 It is concluded that a stronger association and interaction of PDC-109 with phosphatidylcholine leads to an enhanced fraction of immobilized cholesterol analogues, but not to a phospholipid-dependent specific interaction between the protein and cholesterol. Phosphatidylcholines 76-95 seminal plasma protein PDC-109 Bos taurus 63-70 12355253-7 2002 Moreover, the interaction of PDC-109 with various spin-labelled analogues of phosphatidylcholine (lysoPC, diacylPC) was investigated. Phosphatidylcholines 77-96 seminal plasma protein PDC-109 Bos taurus 29-36 12353276-5 2002 The molar ratio of PTC to PC increased fourfold in differentiated 3T3 F442A cells compared to undifferentiated cells, suggesting a substantial increase in CTP:phosphocholine cytidylyltransferase activity with differentiation. Phosphatidylcholines 19-22 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 155-194 12297311-0 2002 Effect of cholesterol on the interaction of seminal plasma protein, PDC-109 with phosphatidylcholine membranes. Phosphatidylcholines 81-100 seminal plasma protein PDC-109 Bos taurus 44-75 12221122-4 2002 Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways. Phosphatidylcholines 102-121 choline/ethanolamine phosphotransferase 1 Homo sapiens 17-22 12213494-2 2002 Hydrolysis of SL phosphatidylcholine (PC) by PLD2 produces phosphatidic acid (PA), which is then converted to 1,2 diacylglycerol (DAG) by the action of phosphatidate phosphohydrolase type 2 (PAP2). Phosphatidylcholines 17-36 phospholipase D2 Rattus norvegicus 45-49 12213494-2 2002 Hydrolysis of SL phosphatidylcholine (PC) by PLD2 produces phosphatidic acid (PA), which is then converted to 1,2 diacylglycerol (DAG) by the action of phosphatidate phosphohydrolase type 2 (PAP2). Phosphatidylcholines 38-40 phospholipase D2 Rattus norvegicus 45-49 12217395-1 2002 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12217395-1 2002 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12221122-4 2002 Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways. Phosphatidylcholines 102-121 carnitine palmitoyltransferase 1A Homo sapiens 27-31 12221122-5 2002 CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively. Phosphatidylcholines 111-130 choline/ethanolamine phosphotransferase 1 Homo sapiens 0-5 12221122-5 2002 CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively. Phosphatidylcholines 186-205 choline/ethanolamine phosphotransferase 1 Homo sapiens 0-5 12221122-5 2002 CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively. Phosphatidylcholines 186-205 carnitine palmitoyltransferase 1A Homo sapiens 169-173 12221122-8 2002 The rate-limiting step for phosphatidylcholine synthesis is catalyzed by the amphitropic CTP:phosphocholine cytidylyltransferase alpha, which is found in the nucleus in most cell types. Phosphatidylcholines 27-46 phosphate cytidylyltransferase 1A, choline Homo sapiens 89-134 12221122-10 2002 Thus, substrate channeling of the CDP-choline produced by CTP:phosphocholine cytidylyltransferase alpha to nuclear located CEPT1 is the mechanism by which upregulation of the CDP-choline pathway increases de novo phosphatidylcholine biosynthesis. Phosphatidylcholines 213-232 phosphate cytidylyltransferase 1A, choline Homo sapiens 58-103 12221122-10 2002 Thus, substrate channeling of the CDP-choline produced by CTP:phosphocholine cytidylyltransferase alpha to nuclear located CEPT1 is the mechanism by which upregulation of the CDP-choline pathway increases de novo phosphatidylcholine biosynthesis. Phosphatidylcholines 213-232 choline/ethanolamine phosphotransferase 1 Homo sapiens 123-128 12226489-6 2002 The enzymatic activity of the purified recombinant AtPLA IVA toward phosphatidylcholine was dependent on Ca(2+), saturated at 0.5 mM, and had a pH optimum of about 7.0. Phosphatidylcholines 68-87 Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein Arabidopsis thaliana 51-60 12077151-7 2002 These data suggest that PC, rather than PE and PG, is the major in vivo substrate of PLD alpha. Phosphatidylcholines 24-26 phospholipase D alpha 1 Arabidopsis thaliana 85-88 12100999-0 2002 CTP:phosphocholine cytidylyltransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcholine. Phosphatidylcholines 151-170 proline rich transmembrane protein 2 Homo sapiens 44-60 12021277-4 2002 sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s. Phosphatidylcholines 49-68 phospholipase A2, group X Mus musculus 0-7 12039969-6 2002 Purified His-cPLA(2)gamma does not exhibit phospholipase A(1) activity, but sequentially hydrolyzes fatty acid from the sn-2 and sn-1 positions of phosphatidylcholine. Phosphatidylcholines 147-166 phospholipase A2 group IVC Homo sapiens 13-25 12023904-2 2002 In addition to transferring phosphatidylinositol (PI) and phosphatidylcholine (PC), PITPbeta has been shown to transfer sphingomyelin (SM), and this has led to the suggestion that PITPbeta is important for the regulation of SM metabolism. Phosphatidylcholines 58-77 phosphatidylinositol transfer protein beta Homo sapiens 180-188 12021277-4 2002 sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s. Phosphatidylcholines 49-68 ATPase, class II, type 9A Mus musculus 290-293 12117562-11 2002 The study of PC biosynthetic enzymes showed that PLC inhibitors affect CTP:phosphocholine cytidylyltransferase (CCT) activity while PGD(2) operates on CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CPT), both activities associated to papillary enriched-nuclei fraction. Phosphatidylcholines 13-15 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 71-110 12172641-6 2002 Annexin VI purified from rabbit skeletal muscle displayed Ca2+-dependent binding to liposomes containing phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine. Phosphatidylcholines 147-166 annexin A6 Oryctolagus cuniculus 0-10 12016218-5 2002 Furthermore, the extracellular domain of rat SR-BI fused with human Fc (SRBIecd-Fc) bound to PS with a dissociation equilibrium constant of 2.4 x 10(-7) m in a cell-free solid-phase assay, whereas other phospholipids including phosphatidylethanolamine, phosphatidylinositol, and phosphatidylcholine were poor binding targets. Phosphatidylcholines 279-298 scavenger receptor class B, member 1 Rattus norvegicus 45-50 12117562-11 2002 The study of PC biosynthetic enzymes showed that PLC inhibitors affect CTP:phosphocholine cytidylyltransferase (CCT) activity while PGD(2) operates on CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CPT), both activities associated to papillary enriched-nuclei fraction. Phosphatidylcholines 13-15 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 112-115 12134061-2 2002 This essential Sec14p requirement for Golgi function is bypassed by mutations in any one of seven genes that control phosphatidylcholine or phosphoinositide metabolism. Phosphatidylcholines 117-136 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 15-21 11955950-6 2002 Recently, an oxidized phosphatidylcholine was identified as a potent alternative (patho)physiological natural ligand of PPARgamma. Phosphatidylcholines 22-41 peroxisome proliferator activated receptor gamma Homo sapiens 120-129 12780970-7 2002 MAIN RESULTS: High-intensity xanthine oxidase stress significantly increased type II cell DNA strand breakage, inhibited de novo phosphatidyl choline synthesis, diminished mitochondrial integrity, and enhanced lipid peroxidation in the absence of overt cytolysis. Phosphatidylcholines 129-149 xanthine dehydrogenase Mus musculus 29-45 12021827-2 2002 Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Phosphatidylcholines 115-134 cut like homeobox 1 Homo sapiens 62-65 11980474-0 2002 Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria. Phosphatidylcholines 48-67 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 72-106 11980474-0 2002 Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria. Phosphatidylcholines 48-67 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 108-113 11980474-9 2002 The significance of the observed interactions between Gut2p and PC is discussed. Phosphatidylcholines 64-66 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 54-59 12054536-6 2002 This is the first evidence for phosphatidylcholine-hydrolyzing phospholipase C in plant signal transduction. Phosphatidylcholines 31-50 phosphoinositide phospholipase C 2-like Nicotiana tabacum 63-78 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12052891-1 2002 CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells. Phosphatidylcholines 179-198 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 12052891-1 2002 CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells. Phosphatidylcholines 179-198 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-56 12052891-1 2002 CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells. Phosphatidylcholines 200-206 choline-phosphate cytidylyltransferase A Cricetulus griseus 0-45 12052891-1 2002 CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells. Phosphatidylcholines 200-206 choline-phosphate cytidylyltransferase A Cricetulus griseus 47-56 12052891-10 2002 Activation and nuclear export of CCT alpha were early events in FOH-induced apoptosis that contributed to altered PtdCho synthesis and, in conjunction with caspase cleavage, excluded CCT alpha from the nucleus. Phosphatidylcholines 114-120 choline-phosphate cytidylyltransferase A Cricetulus griseus 33-42 11923286-9 2002 For the first time direct observations by atomic force microscopy show (i) that a certain minimal concentration of SP-B is required for the formation of layered protrusions upon film compression, (ii) that protrusion height depends on whether the phospholipids contain an unsaturated fatty acyl chain, and (iii) that protrusion height also depends on whether the unsaturated acyl chain is present in phosphatidylcholine or in phosphatidylglycerol. Phosphatidylcholines 400-419 surfactant protein B Homo sapiens 115-119 12044149-6 2002 Strikingly, the effective length of KALP peptides in the lipid systems investigated here is much smaller than that previously found for the same peptides in phosphatidylcholine. Phosphatidylcholines 157-176 anosmin 2, pseudogene Homo sapiens 36-40 12034570-1 2002 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Phosphatidylcholines 119-138 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12034570-1 2002 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Phosphatidylcholines 140-142 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12111845-5 2002 Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids. Phosphatidylcholines 181-200 phospholipase A2 group IIA Homo sapiens 82-89 12111845-5 2002 Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids. Phosphatidylcholines 202-204 phospholipase A2 group IIA Homo sapiens 82-89 12031288-2 2002 Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic juice. Phosphatidylcholines 78-97 carboxyl ester lipase Rattus norvegicus 162-182 12031288-2 2002 Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic juice. Phosphatidylcholines 99-101 carboxyl ester lipase Rattus norvegicus 162-182 12031288-4 2002 Cholesterol esterase dose-dependently accelerated the incorporation of cholesterol into differentiated Caco-2 cells, only when cholesterol was solubilized in PC-containing micelles. Phosphatidylcholines 158-160 carboxyl ester lipase Homo sapiens 0-20 12031288-9 2002 The addition of cholesterol esterase to bile salt micelles accelerated the release of micellar cholesterol in a dose-dependent manner, only when the micelles contained PC. Phosphatidylcholines 168-170 carboxyl ester lipase Homo sapiens 16-36 12054536-0 2002 Down-regulation by elicitors of phosphatidylcholine-hydrolyzing phospholipase C and up-regulation of phospholipase A in plant cells. Phosphatidylcholines 32-51 phosphoinositide phospholipase C 2-like Nicotiana tabacum 64-79 12054536-4 2002 As phosphatidic acid was only a very minor fluorescent metabolite DAG is hypothesized to arise by the action of a phosphatidylcholine-hydrolyzing phospholipase C which was down-regulated by elicitors. Phosphatidylcholines 114-133 phosphoinositide phospholipase C 2-like Nicotiana tabacum 146-161 12059777-5 2002 An enzymatic system is proposed for a cascade of enzymatic reactions simulating lipohydroperoxide metabolism in living cells, including successive free radical oxidation of phosphatidylcholine polyenoic acyls, reduction of their hydroperoxy-derivatives, and hydrolysis of fatty acid residues in the course of catalysis mediated by animal C-15 lipoxygenase, glutathione S-transferase, and phospholipase A(2), respectively. Phosphatidylcholines 173-192 glutathione S-transferase kappa 1 Homo sapiens 357-382 12021827-2 2002 Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Phosphatidylcholines 136-142 cut like homeobox 1 Homo sapiens 62-65 11919088-10 2002 These data suggest that the cell-cycle changes in PC synthesis are likely not due to alterations in CCTalpha expression and degradation but are primarily a consequence of changes in CCTalpha activity, phosphorylation, and membrane affinity. Phosphatidylcholines 50-52 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 182-190 12575328-6 2002 CONCLUSION: VIP in the lung may be one of the key regulators involved in the synthesis of phosphatidylcholine mediated by PKC and calmodulin. Phosphatidylcholines 90-109 vasoactive intestinal peptide Rattus norvegicus 12-15 12575328-6 2002 CONCLUSION: VIP in the lung may be one of the key regulators involved in the synthesis of phosphatidylcholine mediated by PKC and calmodulin. Phosphatidylcholines 90-109 calmodulin 1 Rattus norvegicus 130-140 11796736-3 2002 The model building, electrostatic potential calculation, and in vitro membrane binding studies of the isolated C2-like domain of 5-LO and selected mutants show that this Ca(2+)-dependent domain selectively binds zwitterionic phosphatidylcholine, which is conferred by tryptophan residues (Trp(13), Trp(75), and Trp(102)) located in the putative Ca(2+)-binding loops. Phosphatidylcholines 225-244 arachidonate 5-lipoxygenase Homo sapiens 129-133 11796736-4 2002 The spatiotemporal dynamics of the enhanced green fluorescence protein-tagged C2-like domain of 5-LO and mutants in living cells also show that the phosphatidylcholine selectivity of the C2-like domain accounts for the specific targeting of 5-LO to the nuclear envelope. Phosphatidylcholines 148-167 arachidonate 5-lipoxygenase Homo sapiens 96-100 11796736-4 2002 The spatiotemporal dynamics of the enhanced green fluorescence protein-tagged C2-like domain of 5-LO and mutants in living cells also show that the phosphatidylcholine selectivity of the C2-like domain accounts for the specific targeting of 5-LO to the nuclear envelope. Phosphatidylcholines 148-167 arachidonate 5-lipoxygenase Homo sapiens 241-245 11880299-1 2002 Tumor necrosis factor (TNF)-alpha is a major cytokine implicated in inducing acute and chronic lung injury, conditions associated with surfactant phosphatidylcholine (PtdCho) deficiency. Phosphatidylcholines 146-165 tumor necrosis factor Mus musculus 0-33 11880299-1 2002 Tumor necrosis factor (TNF)-alpha is a major cytokine implicated in inducing acute and chronic lung injury, conditions associated with surfactant phosphatidylcholine (PtdCho) deficiency. Phosphatidylcholines 167-173 tumor necrosis factor Mus musculus 0-33 11880299-2 2002 Acutely, TNF-alpha decreases PtdCho synthesis but stimulates surfactant secretion. Phosphatidylcholines 29-35 tumor necrosis factor Mus musculus 9-18 11880299-9 2002 Reduced parenchymal PtdCho synthesis appears to be attributed to CCT enzyme that is physiologically inactivated by ceramide or by diminished availability of activating lipids. Phosphatidylcholines 20-26 t-complex protein 1 Mus musculus 65-68 11919173-7 2002 ET-18-OCH3 also inhibited PtdCho synthesis. Phosphatidylcholines 26-32 ochre Mus musculus 6-9 11951953-1 2002 The interaction of the chemical carcinogen benzo[a]pyrene (BaP) with phosphatidylcholine membranes has been investigated by using various physical techniques. Phosphatidylcholines 69-88 prohibitin 2 Homo sapiens 59-62 12024107-2 2002 In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs). Phosphatidylcholines 67-86 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 269-275 11973292-1 2002 Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation. Phosphatidylcholines 34-53 phospholipase D Saccharomyces cerevisiae S288C 25-30 11973292-1 2002 Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation. Phosphatidylcholines 34-53 phospholipase D Saccharomyces cerevisiae S288C 114-129 11973292-1 2002 Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation. Phosphatidylcholines 34-53 phospholipase D Saccharomyces cerevisiae S288C 131-134 11916983-3 2002 Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast phosphatidylinositol/phosphatidylcholine Sec14p. Phosphatidylcholines 182-201 oxysterol-binding protein KES1 Saccharomyces cerevisiae S288C 0-5 11916983-3 2002 Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast phosphatidylinositol/phosphatidylcholine Sec14p. Phosphatidylcholines 182-201 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 202-208 12024107-2 2002 In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs). Phosphatidylcholines 67-86 matrix metallopeptidase 13 Rattus norvegicus 281-308 12024107-2 2002 In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs). Phosphatidylcholines 67-86 matrix metallopeptidase 13 Rattus norvegicus 310-316 11855861-1 2002 The phosphatidylcholine transfer protein (PC-TP) is a specific transporter of phosphatidylcholine (PC) between membranes. Phosphatidylcholines 4-23 phosphatidylcholine transfer protein Homo sapiens 42-47 12191592-2 2002 PLD metabolizes phosphatidylcholine to generate phosphatidic acid (PA). Phosphatidylcholines 16-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12449015-4 2002 The PAFR recognizes the short residue, an acetate residue, at the 2-position of the phospholipid, and this sharp specificity precludes receptor activation by other related phosphatidylcholines. Phosphatidylcholines 172-192 platelet activating factor receptor Homo sapiens 4-8 12449015-7 2002 Oxidation of LDLs fragments and derivatizes the fatty acid residues at the 2-position of the phosphatidylcholines that comprise the shell of LDLs, an event that allows certain oxidized phospholipids to interact with and activate the PAFR. Phosphatidylcholines 93-113 platelet activating factor receptor Homo sapiens 233-237 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. Phosphatidylcholines 119-138 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-46 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. Phosphatidylcholines 119-138 phosphatidylethanolamine N-methyltransferase Homo sapiens 48-53 12013527-0 2002 Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. Phosphatidylcholines 38-57 PCNA clamp associated factor Rattus norvegicus 8-34 12013527-2 2002 PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted). Phosphatidylcholines 14-33 PCNA clamp associated factor Rattus norvegicus 0-3 12013527-2 2002 PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted). Phosphatidylcholines 128-147 PCNA clamp associated factor Rattus norvegicus 0-3 12013527-2 2002 PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted). Phosphatidylcholines 128-147 PCNA clamp associated factor Rattus norvegicus 0-3 12013527-4 2002 A study of the mechanism through which PAF exerts its stimulatory effect was carried out adding different agents that are well known stimulants of phosphatidylcholine secretion. Phosphatidylcholines 147-166 PCNA clamp associated factor Rattus norvegicus 39-42 12013527-5 2002 Thus, PAF increased the TPA- and terbutaline-stimulated phosphatidylcholine secretion, that are PKC and PKA activators respectively, suggesting the involvement of both protein kinases in the process. Phosphatidylcholines 56-75 PCNA clamp associated factor Rattus norvegicus 6-9 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. Phosphatidylcholines 119-138 phosphatidylethanolamine N-methyltransferase Homo sapiens 48-52 11829742-0 2002 Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Phosphatidylcholines 39-58 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 122-161 11839534-5 2002 IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose. Phosphatidylcholines 81-100 interleukin-1 alpha Ovis aries 0-10 11839534-5 2002 IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose. Phosphatidylcholines 81-100 interleukin-1 beta Ovis aries 15-24 11891260-1 2002 Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains. Phosphatidylcholines 46-65 phospholipase D P1 Arabidopsis thaliana 76-86 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 65-84 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 65-84 cut-like homeobox 1 Rattus norvegicus 156-159 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 86-90 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 86-90 cut-like homeobox 1 Rattus norvegicus 156-159 11880242-2 2002 In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT). Phosphatidylcholines 40-44 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 48-72 11880242-2 2002 In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT). Phosphatidylcholines 40-44 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 74-78 11841283-2 2002 Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine. Phosphatidylcholines 160-179 polypyrimidine tract binding protein 3 Homo sapiens 38-43 12033451-3 2002 In this study we investigated the oxidation of various substrates (linoleic acid, methyl linoleate, phosphatidylcholine, isolated LDL, and human plasma) by the arachidonate 15-lipoxygenases from rabbit reticulocytes and soybeans aiming at elucidating the effects of substrate, lipoxygenase and reaction milieu on the contribution and mechanism of random oxidation and also the effect of antioxidant. Phosphatidylcholines 100-119 linoleate 9S-lipoxygenase-4 Glycine max 176-188 12033451-6 2002 When phosphatidylcholine liposomes and LDL were oxygenated by soybean lipoxygenase, the product pattern was found to be exclusively regio-, stereo-, and enantio-random. Phosphatidylcholines 5-24 linoleate 9S-lipoxygenase-4 Glycine max 70-82 11880242-7 2002 Of the newly synthesized PtdC, about 70% was derived de novo and 30% was by PEMT. Phosphatidylcholines 25-29 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 76-80 11751880-1 2002 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein of unknown function that catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 129-149 phosphatidylcholine transfer protein Cricetulus griseus 0-36 11751880-1 2002 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein of unknown function that catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 129-149 phosphatidylcholine transfer protein Cricetulus griseus 38-43 11751880-8 2002 These findings suggest that a physiological function of PC-TP is to replenish the plasma membrane with phosphatidylcholines that are removed during pre-beta-HDL particle formation due to the activity of ATP-binding cassette A1. Phosphatidylcholines 103-123 phosphatidylcholine transfer protein Cricetulus griseus 56-61 11829742-1 2002 Lipid-deprived mice increase alveolar surfactant disaturated phosphatidylcholine (DSPtdCho) synthesis compared with mice fed a standard diet by increasing expression of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme for DSPtdCho synthesis. Phosphatidylcholines 61-80 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 169-208 11853701-2 2002 A significant increase in phosphatidylcholine (PC) labeling was observed when cortical slices, prelabeled with [32P]orthophosphate, were incubated for 30 min in the presence of Ang-(1-7) (1 pM to 100 nM). Phosphatidylcholines 26-45 angiogenin Rattus norvegicus 177-185 11853701-2 2002 A significant increase in phosphatidylcholine (PC) labeling was observed when cortical slices, prelabeled with [32P]orthophosphate, were incubated for 30 min in the presence of Ang-(1-7) (1 pM to 100 nM). Phosphatidylcholines 47-49 angiogenin Rattus norvegicus 177-185 11853701-5 2002 However, losartan potentiated the effect of 100 nM Ang-(1-7) on PC biosynthesis. Phosphatidylcholines 64-66 angiogenin Rattus norvegicus 51-59 12186778-4 2002 Phosphatidylcholine and phosphatidylethanolamine, the major constituents of the mitochondrial inner membrane, stimulated purified Endo G activity 5- to 10-fold. Phosphatidylcholines 0-19 endonuclease G Homo sapiens 130-136 12043230-3 2002 sPLA2 was measured with enzyme immunoassay, catalytic activity--using aqueous emulsion of 14C-labelled phosphatidylcholine. Phosphatidylcholines 103-122 phospholipase A2 group X Homo sapiens 0-5 11802709-3 2002 The cooperative binding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces docking to phosphatidylcholine (PC) membranes. Phosphatidylcholines 127-146 phospholipase A2 group IVA Homo sapiens 63-91 11802709-3 2002 The cooperative binding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces docking to phosphatidylcholine (PC) membranes. Phosphatidylcholines 148-150 phospholipase A2 group IVA Homo sapiens 63-91 11902115-7 2002 Of special interest was the prevalence of phospholipids (phosphatidylcholine, diacyl-phosphatidylethanolamine, and phosphatidylserine) with 22:6n-3 in both the sn-1 and sn-2 positions of SPM and these phospholipid species were significantly higher in apoE-deficient mice as compared to control mice. Phosphatidylcholines 57-76 solute carrier family 38, member 3 Mus musculus 160-164 11805144-10 2002 In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression. Phosphatidylcholines 210-229 platelet-activating factor receptor Mus musculus 99-111 11805144-10 2002 In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression. Phosphatidylcholines 210-229 patchy fur Mus musculus 99-102 11805144-10 2002 In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression. Phosphatidylcholines 210-229 patchy fur Mus musculus 99-102 11772399-3 2002 Fluorescence emission spectra for the single Trp residue of SLN suggest that SLN incorporates fully into bilayers of dioleoylphosphatidylcholine, but only partially into bilayers of phosphatidylcholines with long (C(22) or C(24)) fatty acyl chains. Phosphatidylcholines 182-202 sarcolipin Homo sapiens 60-63 11772399-3 2002 Fluorescence emission spectra for the single Trp residue of SLN suggest that SLN incorporates fully into bilayers of dioleoylphosphatidylcholine, but only partially into bilayers of phosphatidylcholines with long (C(22) or C(24)) fatty acyl chains. Phosphatidylcholines 182-202 sarcolipin Homo sapiens 77-80 11779181-0 2002 Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite. Phosphatidylcholines 58-77 paraoxonase 1 Homo sapiens 24-37 11779181-7 2002 In addition, PON-1 hydrolyzed the phosphatidylcholine core aldehydes 1-palmitoyl-2-(9-oxo)nonanoyl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-(5-oxo)valeroyl-sn-glycero-3-phosphocholine to lysophosphatidylcholine. Phosphatidylcholines 34-53 paraoxonase 1 Homo sapiens 13-18 11779181-10 2002 We conclude that PON-1 minimizes the accumulation of phosphatidylcholine oxidation products by the hydrolysis of phosphatidylcholine isoprostanes and core aldehydes to lysophosphatidylcholine with a serine esterase-independent mechanism. Phosphatidylcholines 53-72 paraoxonase 1 Homo sapiens 17-22 11796739-1 2002 Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Phosphatidylcholines 97-116 cut like homeobox 1 Homo sapiens 44-47 11796739-1 2002 Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Phosphatidylcholines 118-124 cut like homeobox 1 Homo sapiens 44-47 11741598-1 2001 Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A(2) (sPLA(2)-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types. Phosphatidylcholines 45-64 phospholipase A2, group X Mus musculus 66-101 11583989-1 2001 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC). Phosphatidylcholines 99-118 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 11583989-1 2001 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC). Phosphatidylcholines 99-118 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 11583989-1 2001 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC). Phosphatidylcholines 120-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 11583989-1 2001 CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC). Phosphatidylcholines 120-122 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 11583989-5 2001 The unusual requirements of the lung for PC synthesis and, therefore, CCT activity suggest a unique mechanism of regulation and possibly localization of CCT. Phosphatidylcholines 41-43 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 153-156 11741598-1 2001 Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A(2) (sPLA(2)-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types. Phosphatidylcholines 45-64 phospholipase A2, group X Mus musculus 104-113 11908825-2 2001 Ethanolic solution of Gb3 containing cholesterol and phosphatidylcholine was passively adsorbed onto the wells of microtiter plate, and Gb3-bound VT1 and VT2 were detected by anti-VT1 and anti-VT2 mAbs, respectively. Phosphatidylcholines 53-72 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 22-25 11814059-1 2001 A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate. Phosphatidylcholines 82-102 phospholipid transfer protein Oryctolagus cuniculus 9-38 11814059-1 2001 A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate. Phosphatidylcholines 82-102 phospholipid transfer protein Oryctolagus cuniculus 40-48 11814059-1 2001 A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate. Phosphatidylcholines 104-106 phospholipid transfer protein Oryctolagus cuniculus 9-38 11814059-1 2001 A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate. Phosphatidylcholines 104-106 phospholipid transfer protein Oryctolagus cuniculus 40-48 11721001-3 2001 Colipase adsorption rates to phosphatidylcholine/reactant mixed monolayers depended strongly on lipid composition and packing. Phosphatidylcholines 29-48 colipase Homo sapiens 0-8 11721001-4 2001 Paradoxically, reactants lowered colipase adsorption rates only if phosphatidylcholine was present. Phosphatidylcholines 67-86 colipase Homo sapiens 33-41 11721001-5 2001 This suggests that interactions between phosphatidylcholine and reactants create dynamic complexes that impede colipase adsorption. Phosphatidylcholines 40-59 colipase Homo sapiens 111-119 11721001-7 2001 Colipase binding rate depends nonlinearly on the two-dimensional concentration of phosphatidylcholine. Phosphatidylcholines 82-101 colipase Homo sapiens 0-8 11564739-10 2001 Catabolism of all major HDL lipids can occur via SR-BI with the relative selective uptake rate constants for CE, free cholesterol, triglycerides (triolein), and phosphatidylcholine being 1, 1.6, 0.7, and 0.2, respectively. Phosphatidylcholines 161-180 scavenger receptor class B member 1 Homo sapiens 49-54 11750883-10 2001 Repeated washing of the microsomal freeze-dried fraction with benzene resulted in a complete loss of DAGAT activity in the standard assay, but the activity was restored by the addition of DAG plus phosphatidylcholine or Tween 20 in benzene. Phosphatidylcholines 197-216 Diacylglycerol O-acyltransferase 1-2 Zea mays 101-106 11546763-5 2001 In GPAT-overexpressing cells, the incorporation of label into phospholipid, particularly phosphatidylcholine, decreased 30%, despite normal growth rate and phospholipid content, suggesting that exogenous oleate was directed primarily toward triacylglycerol synthesis. Phosphatidylcholines 89-108 glycerol-3-phosphate acyltransferase, mitochondrial Homo sapiens 3-7 11533033-3 2001 To better understand apoE-lipid interactions on lipoprotein surfaces, we determined the thermodynamic parameters for binding of apoE4 and its 22- and 10-kDa fragments to triolein-egg phosphatidylcholine emulsions using a centrifugation assay and titration calorimetry. Phosphatidylcholines 183-202 apolipoprotein E Homo sapiens 128-133 11762137-5 2001 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction. Phosphatidylcholines 102-121 phosphatidylethanolamine N-methyltransferase Homo sapiens 11-53 11694619-6 2001 The addition of PLA2 from porcine pancreas to the medium also enhanced the uptake of carotenoids from micelles containing PC. Phosphatidylcholines 122-124 phospholipase A2 group IB Homo sapiens 16-20 11673871-4 2001 In addition to requiring Smad activity, based upon the effects of specific inhibitors, the TGF-beta intracellular signaling pathway requires the activity of a phosphatidylcholine-specific phospholipase C, a protein kinase C, and one or more tyrosine kinases. Phosphatidylcholines 159-178 transforming growth factor beta 1 Homo sapiens 91-99 11694619-5 2001 Uptake of micellar beta-carotene and lutein was greatly suppressed by phosphatidylcholine (PC) in a dose-dependent manner, whereas lysophosphatidylcholine (lysoPC), the lipolysis product of PC by phospholipase A2 (PLA2), markedly enhanced both beta-carotene and lutein uptake. Phosphatidylcholines 91-93 phospholipase A2 group IB Homo sapiens 196-212 11694619-5 2001 Uptake of micellar beta-carotene and lutein was greatly suppressed by phosphatidylcholine (PC) in a dose-dependent manner, whereas lysophosphatidylcholine (lysoPC), the lipolysis product of PC by phospholipase A2 (PLA2), markedly enhanced both beta-carotene and lutein uptake. Phosphatidylcholines 91-93 phospholipase A2 group IB Homo sapiens 214-218 11762137-5 2001 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction. Phosphatidylcholines 102-121 phosphatidylethanolamine N-methyltransferase Homo sapiens 55-59 11762137-5 2001 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction. Phosphatidylcholines 123-125 phosphatidylethanolamine N-methyltransferase Homo sapiens 11-53 11762137-5 2001 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction. Phosphatidylcholines 123-125 phosphatidylethanolamine N-methyltransferase Homo sapiens 55-59 11758754-0 2001 Distribution and diffusion of sodium taurocholate and egg phosphatidylcholine aggregates in rat intestinal mucin. Phosphatidylcholines 58-77 solute carrier family 13 member 2 Rattus norvegicus 107-112 11745043-1 2001 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. Phosphatidylcholines 158-177 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 48-52 11758754-1 2001 PURPOSE: The permeability of rat intestinal mucin (RIM) to sodium taurocholate/egg phosphatidylcholine (TC/PC)-mixed micelles has been investigated. Phosphatidylcholines 83-102 solute carrier family 13 member 2 Rattus norvegicus 44-49 11745043-1 2001 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. Phosphatidylcholines 158-177 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 65-69 11580285-1 2001 The conformation and amide proton exchangeability of the peptide acetyl-K(2)-A(24)-K(2)-amide (A(24)) and its interaction with phosphatidylcholine bilayers were examined by a variety of physical techniques. Phosphatidylcholines 127-146 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 77-82 11591753-1 2001 We have recently shown that IL-3R occupancy activates a phosphatidylcholine-specific phospholipase C, and the sustained diacylglycerol accumulation subsequently activates protein kinase C (PKC). Phosphatidylcholines 56-75 interleukin 3 receptor subunit alpha Homo sapiens 28-33 11504713-4 2001 Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates. Phosphatidylcholines 27-46 surfactant associated protein A1 Mus musculus 76-80 11504713-4 2001 Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates. Phosphatidylcholines 27-46 surfactant protein A1 Rattus norvegicus 85-90 11504713-4 2001 Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates. Phosphatidylcholines 27-46 surfactant associated protein A1 Mus musculus 86-90 11580285-1 2001 The conformation and amide proton exchangeability of the peptide acetyl-K(2)-A(24)-K(2)-amide (A(24)) and its interaction with phosphatidylcholine bilayers were examined by a variety of physical techniques. Phosphatidylcholines 127-146 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 95-100 11580285-6 2001 Also, when dispersed with phosphatidylcholine in aqueous media, the conformation and thermal stability of A(24) are not significantly altered by the presence of the phospholipid or by its gel/liquid-crystalline phase transition. Phosphatidylcholines 26-45 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 106-111 11590214-2 2001 The principal acceptors of unesterified cholesterol (UC) from cultured cells are small pre-beta-HDL, which we have shown increase in plasma during intravenous infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs in humans. Phosphatidylcholines 190-209 apolipoprotein A1 Homo sapiens 211-220 11557604-8 2001 [(3)H]choline incorporation into total phosphatidylcholine was increased by VEGF treatment, but incorporation into disaturated phosphatidylcholine was not affected by exogenous VEGF. Phosphatidylcholines 39-58 vascular endothelial growth factor A Homo sapiens 76-80 11706993-1 2001 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11706993-1 2001 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11590219-1 2001 We have previously identified a single amino acid mutation (hE149A) in human LCAT that increases its in vitro reactivity with phosphatidylcholine species containing sn-2 arachidonate (Wang et al. Phosphatidylcholines 126-145 lecithin-cholesterol acyltransferase Homo sapiens 77-81 11768152-2 2001 In general, monoenoic and dienoic acids are found in the sn-2 acyl chain of phosphatidylcholine (PtdCho), whereas polyenoic acids are in phosphatidylethanolamine (PtdEth). Phosphatidylcholines 76-95 solute carrier family 38 member 5 Homo sapiens 57-61 11768161-6 2001 The c9,t11-CLA isomer decreased (P < 0.05) uptake of 14C-AA into phosphatidylcholine while increasing (P < 0.05) uptake into phosphatidylethanolamine in both cell lines. Phosphatidylcholines 68-87 complement C9 Homo sapiens 4-14 11523993-6 2001 Differential scanning calorimetry results demonstrate that NAP-22 promotes domain formation in liposomes composed of cholesterol and phosphatidylcholine. Phosphatidylcholines 133-152 brain abundant membrane attached signal protein 1 Homo sapiens 59-65 11563837-0 2001 Role of calcium-independent phospholipases (iPLA(2)) in phosphatidylcholine metabolism. Phosphatidylcholines 56-75 phospholipase A2, group VI Mus musculus 44-51 11563837-1 2001 The proposed role of calcium-independent phospholipase A(2) (iPLA(2)) in membrane phospholipid homeostasis was tested by examining the perturbation of phosphatidylcholine metabolism by enzyme overexpression. Phosphatidylcholines 151-170 phospholipase A2, group VI Mus musculus 21-59 11563837-1 2001 The proposed role of calcium-independent phospholipase A(2) (iPLA(2)) in membrane phospholipid homeostasis was tested by examining the perturbation of phosphatidylcholine metabolism by enzyme overexpression. Phosphatidylcholines 151-170 phospholipase A2, group VI Mus musculus 61-68 11549244-5 2001 APF/CBP (0.1 to 2.4 microg/ml) inhibited ApoA-1 (2 microg/ml) mediated cholesterol efflux from normal fibroblasts in a dose dependent manner but had no effect on aspecific efflux to methyl-beta-cyclodextrin or phosphatidylcholine liposomes. Phosphatidylcholines 210-229 CREB binding protein Homo sapiens 4-7 11523993-7 2001 This is shown by NAP-22-promoted changes in the shape and enthalpy of the phase transition of phosphatidylcholine as well as by the appearance of cholesterol crystallite transitions in membranes composed of phosphatidylcholine with either saturated or unsaturated acyl chains. Phosphatidylcholines 94-113 brain abundant membrane attached signal protein 1 Homo sapiens 17-23 11420051-3 2001 Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase. Phosphatidylcholines 30-32 phospholipase A2 group IB Rattus norvegicus 184-200 11420051-3 2001 Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase. Phosphatidylcholines 30-32 phospholipase A2 group IB Rattus norvegicus 202-206 11478786-1 2001 Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD. Phosphatidylcholines 35-54 superoxide dismutase 1 Homo sapiens 149-152 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 196-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 219-234 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 196-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 11552739-6 2001 Treated cells processed pro-SP-B and pro-SP-C proteins to mature forms and had a higher rate of phosphatidylcholine (PC) synthesis (2-fold) and higher saturation of PC (approximately 34% versus 27%) than controls. Phosphatidylcholines 117-119 surfactant protein C Homo sapiens 41-45 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). Phosphatidylcholines 75-94 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 106-150 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). Phosphatidylcholines 75-94 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 152-156 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). Phosphatidylcholines 96-99 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 106-150 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). Phosphatidylcholines 96-99 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 152-156 11470084-4 2001 In the fluid phase region, the outer hyperfine splitting increases for all phosphatidylcholine spin-label positional isomers, indicating that the chain mobility is decreased by binding avidin. Phosphatidylcholines 75-94 spindlin 1 Homo sapiens 95-99 11478786-1 2001 Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD. Phosphatidylcholines 35-54 superoxide dismutase 1 Homo sapiens 86-106 11478786-1 2001 Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD. Phosphatidylcholines 35-54 superoxide dismutase 1 Homo sapiens 108-111 11478786-1 2001 Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD. Phosphatidylcholines 35-54 superoxide dismutase 1 Homo sapiens 149-152 11536170-6 2001 Recruitment of the gamma chain either by FcgammaRI in cytokine-primed cells or by FcalphaRI in dbcAMP-induced cells couples ligand binding to the activation of phosphatidyl choline-specific phospholipase D. Phosphatidylcholines 160-180 Fc alpha receptor Homo sapiens 82-91 11502229-5 2001 SAMP8 fed the PC combined with vitamin B12 diet had an increased PKC activity and a higher proportion of 22 : 6n-3 than SAMP8 fed the control diet. Phosphatidylcholines 14-16 protein kinase C, beta Mus musculus 65-68 11551535-3 2001 An essential factor in the activation of PC-TP was phosphatidylcholine (PC) present in the folding buffer. Phosphatidylcholines 51-70 phosphatidylcholine transfer protein Bos taurus 41-46 11483407-4 2001 Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D 609) attenuated TNF-alpha-induced ICAM-1 expression. Phosphatidylcholines 59-78 tumor necrosis factor Homo sapiens 142-151 11483407-4 2001 Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D 609) attenuated TNF-alpha-induced ICAM-1 expression. Phosphatidylcholines 59-78 intercellular adhesion molecule 1 Homo sapiens 160-166 11535107-2 2001 A variety of in vitro and in vivo studies, performed by multiple laboratories, suggest that the lipid substrates of this enzyme, PAF and oxidised derivatives of phosphatidylcholines, play important roles as causative factors in many diseases including asthma. Phosphatidylcholines 161-181 PCNA clamp associated factor Homo sapiens 129-132 11514437-1 2001 In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. Phosphatidylcholines 107-126 phospholipase D Saccharomyces cerevisiae S288C 29-44 11514437-1 2001 In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. Phosphatidylcholines 107-126 phospholipase D Saccharomyces cerevisiae S288C 46-49 11514437-1 2001 In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. Phosphatidylcholines 107-126 phospholipase D Saccharomyces cerevisiae S288C 67-72 11514437-7 2001 Choline and phosphatidic acid molecular species profiles during Sec14-independent secretion and meiosis reveal that while strains harboring one of these alleles, spo14S-11, hydrolyze phosphatidylcholine in Sec14-independent secretion, they fail to do so during sporulation or normal vegetative growth. Phosphatidylcholines 183-202 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 64-69 11514437-7 2001 Choline and phosphatidic acid molecular species profiles during Sec14-independent secretion and meiosis reveal that while strains harboring one of these alleles, spo14S-11, hydrolyze phosphatidylcholine in Sec14-independent secretion, they fail to do so during sporulation or normal vegetative growth. Phosphatidylcholines 183-202 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 206-211 11514437-8 2001 These results demonstrate that Spo14 PLD catalytic activity and cellular function can be differentially regulated at the level of phosphatidylcholine hydrolysis. Phosphatidylcholines 130-149 phospholipase D Saccharomyces cerevisiae S288C 31-36 11514437-8 2001 These results demonstrate that Spo14 PLD catalytic activity and cellular function can be differentially regulated at the level of phosphatidylcholine hydrolysis. Phosphatidylcholines 130-149 phospholipase D Saccharomyces cerevisiae S288C 37-40 11320081-2 2001 However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified. Phosphatidylcholines 71-90 paraoxonase 1 Homo sapiens 61-66 11331277-7 2001 In cell culture experiments, phosphatidylcholine-containing liposomes competed efficiently with LDL for binding to LPL. Phosphatidylcholines 29-48 lipoprotein lipase Homo sapiens 115-118 11320081-0 2001 Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor. Phosphatidylcholines 45-64 apolipoprotein A1 Homo sapiens 0-18 11320081-0 2001 Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor. Phosphatidylcholines 45-64 paraoxonase 1 Homo sapiens 116-121 11320081-8 2001 Incubation of apolipoprotein A-I with 1-palmitoyl-2-linoleoyl glycerophosphocholine proteoliposomes in the presence of 3-morpholinosydnonimine or apoAI with phosphatidylcholine hydroperoxides resulted in a significant increase in phosphatidylcholine core aldehydes with no formation of lysophosphatidylcholine. Phosphatidylcholines 157-176 apolipoprotein A1 Homo sapiens 14-32 11320081-2 2001 However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified. Phosphatidylcholines 71-90 apolipoprotein A1 Homo sapiens 23-41 11320081-2 2001 However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified. Phosphatidylcholines 71-90 paraoxonase 1 Homo sapiens 46-59 11320081-10 2001 Purified PON-1 hydrolyzed phosphatidylcholine core aldehydes to lysophosphatidylcholine. Phosphatidylcholines 26-45 paraoxonase 1 Homo sapiens 9-14 11320081-11 2001 We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1. Phosphatidylcholines 102-121 apolipoprotein A1 Homo sapiens 57-74 11320081-11 2001 We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1. Phosphatidylcholines 102-121 paraoxonase 1 Homo sapiens 173-177 11521966-0 2001 Regulation of intestinal apolipoprotein A-I synthesis by dietary phosphatidylcholine in newborn swine. Phosphatidylcholines 65-84 apolipoprotein A1 Sus scrofa 25-43 11435917-8 2001 These results indicate that orexin-A increases [Ca2+]i in VTA dopamine neurons via phosphatidylcholine-specific PLC- and PKC-mediated activation of L- and N-type Ca2+ channels. Phosphatidylcholines 83-102 hypocretin neuropeptide precursor Rattus norvegicus 28-36 11423412-7 2001 A large fraction (~75%) of the reconstituted t-SNARE was laterally mobile with a lateral diffusion coefficient of 7.5 x 10(-9) cm(2)/s in a phosphatidylcholine lipid background. Phosphatidylcholines 140-159 small NF90 (ILF3) associated RNA E Homo sapiens 47-52 11518575-1 2001 The interaction of sodium taurocholate/egg phosphatidylcholine (TC/PC) micelles with mucin was determined to investigate the exclusion of lipids by mucus in the absorption process. Phosphatidylcholines 43-62 solute carrier family 13 member 2 Rattus norvegicus 85-90 11404253-2 2001 Am J Physiol Lung Cell Mol Physiol 281: L98-L107, 2001), we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin. Phosphatidylcholines 237-256 tumor necrosis factor Homo sapiens 78-111 11404253-2 2001 Am J Physiol Lung Cell Mol Physiol 281: L98-L107, 2001), we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin. Phosphatidylcholines 258-260 tumor necrosis factor Homo sapiens 78-111 11500953-12 2001 In conclusion, the results of the present study indicate that in MC3T3-E1 osteoblast-like cells, ET-1 acting through ET receptor links to a stimulation of Pi transport via activation of PKC through both phosphoinositide and phosphatidylcholine hydrolyses. Phosphatidylcholines 224-243 endothelin 1 Mus musculus 97-101 11416880-2 2001 During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and glucocorticoids stimulate the production of surfactant-associated proteins and increase phospholipid synthesis by enhancing the activity of phosphatidylcholine. Phosphatidylcholines 228-247 nuclear receptor subfamily 3 group C member 1 Homo sapiens 28-51 11312259-6 2001 Stern-Volmer analysis of the quenching of PT-(1-46)F4W in the presence and absence of 80% phosphatidylcholine/20% PS vesicles suggested that Trp-4 is positioned within the membrane and protected from aqueous quenching agents whereas Trp-41 remains solvent-accessible in the presence of PS-containing vesicles. Phosphatidylcholines 90-109 transient receptor potential cation channel subfamily C member 4 Homo sapiens 141-146 11376003-1 2001 Previous studies suggest that the steps of the CDP- choline pathway of phosphatidylcholine synthesis are tightly linked in a so-called metabolon. Phosphatidylcholines 71-90 cut like homeobox 1 Homo sapiens 47-50 11389609-6 2001 P-Glycoprotein exhibited a broad specificity for phospholipids, and translocated phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin. Phosphatidylcholines 81-100 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 11410291-10 2001 In addition, we examined the effect of several known enzyme modulators, namely carbenoxolone, phenylarsine oxide and phosphatidylcholine, on 11-cis-retinol dehydrogenase activity. Phosphatidylcholines 117-136 retinol dehydrogenase 5 Homo sapiens 141-169 11294854-2 2001 Analysis of erythrocyte phospholipid metabolism by thin-layer chromatography revealed significant hydrolysis of both phosphatidylcholine and phosphatidylethanolamine during incubation with ionomycin and sPLA(2). Phosphatidylcholines 117-136 phospholipase A2 group X Homo sapiens 203-210 11442029-1 2001 We have modified a reversed-phase (RP8) column by passing through it an aqueous solution of phosphatidylcholine-based liposomes. Phosphatidylcholines 92-111 programmed cell death 2 Homo sapiens 35-38 11400861-0 2001 Metabolism of surfactant phosphatidylcholine molecular species in cftr(tm1HGU/tm1HGU) mice compared to MF-1 mice. Phosphatidylcholines 25-44 cystic fibrosis transmembrane conductance regulator Mus musculus 66-70 11400861-8 2001 In BALF from cftr(tmIHGU/m1HGU) mice, the [methyl-3H]choline label of total PC and individual PC species was significantly increased over control values after 24 hours, but not after 1.5 to 6 hours. Phosphatidylcholines 76-78 cystic fibrosis transmembrane conductance regulator Mus musculus 13-17 11400861-8 2001 In BALF from cftr(tmIHGU/m1HGU) mice, the [methyl-3H]choline label of total PC and individual PC species was significantly increased over control values after 24 hours, but not after 1.5 to 6 hours. Phosphatidylcholines 94-96 cystic fibrosis transmembrane conductance regulator Mus musculus 13-17 11404395-4 2001 The JBT3002-induced production of nitric oxide and TNF-alpha was significantly inhibited by tricyclodecan-9-yl xanthogenate (D609), a selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (PC-PLC). Phosphatidylcholines 157-176 tumor necrosis factor Mus musculus 51-60 11369799-3 2001 Here we applied proton NMR spectroscopy to probe surface phospholipids phosphatidylcholine (PC) and sphingomyelin (SM) of LDL particles during proteolytic degradation of apolipoprotein B-100 (apoB-100). Phosphatidylcholines 71-90 apolipoprotein B Homo sapiens 170-190 11369799-3 2001 Here we applied proton NMR spectroscopy to probe surface phospholipids phosphatidylcholine (PC) and sphingomyelin (SM) of LDL particles during proteolytic degradation of apolipoprotein B-100 (apoB-100). Phosphatidylcholines 92-94 apolipoprotein B Homo sapiens 170-190 11369799-4 2001 Initiation of apoB-100 degradation was accompanied by the abruptly increased intensity of the choline -N(CH(3))(3) resonance of PC molecules, indicating disruption of their interactions with apoB-100. Phosphatidylcholines 128-130 apolipoprotein B Homo sapiens 14-22 11279152-4 2001 Mixing StAR with dansyl-labeled vesicles composed of phosphatidylcholine increased the fluorescence intensity of dansyl emission excited at 280 nm by 10-40%. Phosphatidylcholines 53-72 steroidogenic acute regulatory protein Homo sapiens 7-11 11342631-4 2001 A murine monoclonal anti-prothrombin Ab and three of three LA IgGs enhanced prothrombin binding to 75:25 phosphatidyl choline:phosphatidyl serine vesicles measured by either ultracentrifugation or right-angle light scattering. Phosphatidylcholines 105-125 coagulation factor II, thrombin Homo sapiens 25-36 11358821-4 2001 Addition of 0.1-10 microM doxorubicin to these cells led to a concentration- and time-dependent inhibition of total iPLA(2), as measured using (16:0, [(3)H]18:1) plasmenylcholine and phosphatidylcholine substrates in the presence or absence of calcium. Phosphatidylcholines 183-202 phospholipase A2 group VI Rattus norvegicus 116-123 11336647-8 2001 Liposomes of phosphatidylcholine, phosphatidylserine and their mixture increased secondary structure of 63-193 StAR at pH 7, as monitored by far-UV CD, and stable protein-liposome complexes were identified by gel-permeation chromatography. Phosphatidylcholines 13-32 steroidogenic acute regulatory protein Homo sapiens 111-115 11342631-4 2001 A murine monoclonal anti-prothrombin Ab and three of three LA IgGs enhanced prothrombin binding to 75:25 phosphatidyl choline:phosphatidyl serine vesicles measured by either ultracentrifugation or right-angle light scattering. Phosphatidylcholines 105-125 coagulation factor II, thrombin Homo sapiens 76-87 11290831-5 2001 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines 35-55 C-C motif chemokine ligand 4 Rattus norvegicus 86-90 11432454-1 2001 Phospholipase A2, which is linked to a protein kinase C pathway, hydrolyzes phosphatidylcholine into cis-unsaturated free fatty acids and lysophosphatidylcholine (lysoPC). Phosphatidylcholines 76-95 phospholipase A2 group IB Rattus norvegicus 0-16 11350180-9 2001 Analysis of urinary sulfatides in arylsulfatase A pseudodeficiency patients showed a mild elevation in some individuals when related to urinary phosphatidylcholine. Phosphatidylcholines 144-163 arylsulfatase A Homo sapiens 34-49 11368160-0 2001 Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 307-326 fibroblast growth factor 2 Mus musculus 22-52 11368160-0 2001 Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 307-326 fibroblast growth factor 2 Mus musculus 168-198 11368160-0 2001 Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 307-326 fibroblast growth factor 2 Mus musculus 200-204 11313316-2 2001 MDR3 is the phosphatidylcholine translocator across the hepatocyte canalicular membrane. Phosphatidylcholines 12-31 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 11409160-2 2001 We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 54-73 phospholipase A2 group IB Homo sapiens 26-30 11409160-2 2001 We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 54-73 proprotein convertase subtilisin/kexin type 7 Homo sapiens 82-111 11409160-2 2001 We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 75-77 phospholipase A2 group IB Homo sapiens 26-30 11409160-2 2001 We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER). Phosphatidylcholines 75-77 proprotein convertase subtilisin/kexin type 7 Homo sapiens 82-111 11409160-5 2001 PLA2 may also mediate the hydrolysis of luminal phospholipids other than PC. Phosphatidylcholines 73-75 phospholipase A2 group IB Homo sapiens 0-4 11278673-2 2001 Many potential iPLA(2)beta functions have been proposed, including a signaling role in beta-cell insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid incorporation into P388D1 cell phosphatidylcholine (PC). Phosphatidylcholines 144-163 phospholipase A2, group VI Mus musculus 15-26 11278673-2 2001 Many potential iPLA(2)beta functions have been proposed, including a signaling role in beta-cell insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid incorporation into P388D1 cell phosphatidylcholine (PC). Phosphatidylcholines 247-249 phospholipase A2, group VI Mus musculus 15-26 11254505-7 2001 Exogenous EGF significantly increased surface hydrophobicity and phosphatidylcholine concentration in the mucus layer. Phosphatidylcholines 65-84 epidermal growth factor like 1 Rattus norvegicus 10-13 11290831-5 2001 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines 35-54 C-C motif chemokine ligand 4 Rattus norvegicus 86-90 11290831-5 2001 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines 35-54 C-C motif chemokine ligand 4 Rattus norvegicus 149-153 11290831-5 2001 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines 35-54 platelet activating factor receptor Homo sapiens 241-282 11290831-5 2001 We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation. Phosphatidylcholines 35-55 platelet activating factor receptor Homo sapiens 241-282 11294911-0 2001 Evidence for an intrinsic toxicity of phosphatidylcholine to Sec14p-dependent protein transport from the yeast Golgi complex. Phosphatidylcholines 38-57 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 61-67 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11283284-1 2001 The phosphatidylcholine-specific phospholipase D1 (PLD1) in Saccharomyces cerevisiae is involved in vesicle transport and is essential for sporulation. Phosphatidylcholines 4-23 phospholipase D Saccharomyces cerevisiae S288C 51-55 11106649-4 2001 Heparin nonbinding sPLA(2)-X liberates arachidonic acid most likely from the phosphatidylcholine-rich outer plasma membrane in a glypican-independent manner. Phosphatidylcholines 77-96 phospholipase A2, group X Rattus norvegicus 19-28 11285138-3 2001 Some fluorescent PC was transported in vesicles to a subapical compartment (SAC) or apical recycling compartment (ARC) in polarized HepG2 cells as shown by colocalization with fluorescent sphingomyelin (C6-NBD-SM) and fluorescent transferrin, respectively. Phosphatidylcholines 17-19 transferrin Homo sapiens 230-241 11106649-5 2001 In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. Phosphatidylcholines 130-149 RB transcriptional corepressor like 2 Rattus norvegicus 19-24 11106649-5 2001 In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. Phosphatidylcholines 130-149 glypican 1 Homo sapiens 43-51 11106649-5 2001 In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. Phosphatidylcholines 130-149 phospholipase A2 group IIA Rattus norvegicus 53-69 11172815-4 2001 In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist. Phosphatidylcholines 212-231 ADP ribosylation factor GTPase activating protein 3 Homo sapiens 43-50 11223016-2 2001 CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. Phosphatidylcholines 69-75 cut like homeobox 1 Homo sapiens 0-3 11223016-2 2001 CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. Phosphatidylcholines 120-126 cut like homeobox 1 Homo sapiens 0-3 11251067-0 2001 Phosphatidylcholine synthesis influences the diacylglycerol homeostasis required for SEC14p-dependent Golgi function and cell growth. Phosphatidylcholines 0-19 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 85-91 11251067-2 2001 In yeast, diacylglycerol accepts a phosphocholine moiety through a CPT1-derived cholinephosphotransferase activity to directly synthesize phosphatidylcholine. Phosphatidylcholines 138-157 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 67-71 11251067-4 2001 In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 167-186 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 29-33 11251067-4 2001 In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 167-186 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 39-43 11251067-4 2001 In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 167-186 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 133-137 11251067-5 2001 Alterations in the level of diacylglycerol consumption through alterations in phosphatidylcholine synthesis directly correlated with the level of SEC14-dependent invertase secretion and affected cell viability. Phosphatidylcholines 78-97 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 146-151 11239826-6 2001 The acyl composition of the PA generated by wounding suggests that the major in vivo substrate of PLD in wild-type leaves was PC, and that PG hydrolysis accounted for 10-15% of the wound-induced PA in wild-type leaves. Phosphatidylcholines 126-128 phospholipase D alpha 1 Arabidopsis thaliana 98-101 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 30-49 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 199-203 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 30-49 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 204-208 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 30-49 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 213-217 11084049-1 2001 In mammalian cells, phosphatidylserine is synthesized by two different enzymes, phosphatidylserine synthase (PSS)-1 and -2, via a base exchange reaction in which the head group of a phospholipid (phosphatidylcholine or phosphatidylethanolamine) is replaced by l-serine. Phosphatidylcholines 196-215 phosphatidylserine synthase 1 Homo sapiens 80-122 11243703-1 2001 From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells. Phosphatidylcholines 206-225 tumor necrosis factor Mus musculus 28-37 11243703-1 2001 From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells. Phosphatidylcholines 206-225 tumor necrosis factor Mus musculus 285-294 11243703-1 2001 From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells. Phosphatidylcholines 206-225 tumor necrosis factor Mus musculus 285-294 11282754-2 2001 In these cells, GLP-1(7-36) amide and exendin-4 stimulated phosphatidylcholine secretion (PC) and cAMP formation in a concentration-dependent manner; these effects were reversed by exendin(9-39). Phosphatidylcholines 59-78 glucagon like peptide 1 receptor Homo sapiens 16-21 11248688-10 2001 TMR transport by Pgp reconstituted into proteoliposomes composed of two synthetic phosphatidylcholines showed a highly unusual biphasic temperature dependence. Phosphatidylcholines 82-102 phosphoglycolate phosphatase Homo sapiens 17-20 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 30-49 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 218-222 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 160-179 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 199-203 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 160-179 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 213-217 11078727-4 2001 In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2). Phosphatidylcholines 160-179 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 218-222 11172815-4 2001 In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist. Phosphatidylcholines 212-231 ADP ribosylation factor GTPase activating protein 3 Homo sapiens 115-122 11159449-0 2001 Dynamics of membrane penetration of the fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) group attached to an acyl chain of phosphatidylcholine. Phosphatidylcholines 127-146 OXA1L mitochondrial inner membrane protein Homo sapiens 66-71 11159007-9 2001 IA endotoxin caused rapid and sustained increases in SP mRNAs that preceded the increase in alveolar saturated phosphatidylcholine processing of SP-B and improved lung compliance in prematurely delivered lambs. Phosphatidylcholines 111-130 pulmonary surfactant-associated protein B Ovis aries 145-149 11734063-1 2001 BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh). Phosphatidylcholines 54-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 11341959-5 2001 In accordance with its higher hydrolyzing activity toward phosphatidylcholine, mouse sPLA(2)-X induced a potent production of lysophosphatidylcholine. Phosphatidylcholines 58-77 phospholipase A2, group X Mus musculus 85-94 11314866-4 2001 Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine. Phosphatidylcholines 134-153 annexin A5 Homo sapiens 11-20 11314866-4 2001 Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine. Phosphatidylcholines 134-153 annexin A5 Homo sapiens 86-95 11314866-4 2001 Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine. Phosphatidylcholines 215-234 annexin A5 Homo sapiens 11-20 11133741-4 2001 Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC). Phosphatidylcholines 90-109 tumor necrosis factor Homo sapiens 18-26 11133741-4 2001 Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC). Phosphatidylcholines 90-109 C-C motif chemokine ligand 2 Homo sapiens 35-40 11734063-1 2001 BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh). Phosphatidylcholines 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidylcholines 65-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11347966-2 2001 Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids. Phosphatidylcholines 28-47 phospholipase A2 group VII Homo sapiens 77-84 11347966-2 2001 Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids. Phosphatidylcholines 49-51 phospholipase A2 group VII Homo sapiens 77-84 11329616-5 2001 Western blot analysis showed a significant increase in I- and L-FABP expression following an 8-hour incubation period with butyric acid, oleic acid, and phosphatidylcholine. Phosphatidylcholines 153-172 fatty acid binding protein 1 Homo sapiens 62-68 11123317-6 2001 Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5. Phosphatidylcholines 98-117 CD5 molecule Homo sapiens 85-88 11123317-6 2001 Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5. Phosphatidylcholines 98-117 CD5 molecule Homo sapiens 234-237 11136854-4 2001 In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation. Phosphatidylcholines 90-109 Phospholipase C at 21C Drosophila melanogaster 115-118 11136854-4 2001 In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation. Phosphatidylcholines 90-109 transient receptor potential-like Drosophila melanogaster 150-154 11136854-4 2001 In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation. Phosphatidylcholines 111-113 Phospholipase C at 21C Drosophila melanogaster 115-118 11136854-4 2001 In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation. Phosphatidylcholines 111-113 transient receptor potential-like Drosophila melanogaster 150-154 11269664-0 2001 Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity. Phosphatidylcholines 30-49 cut-like homeobox 1 Rattus norvegicus 54-57 11269664-1 2001 We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline. Phosphatidylcholines 105-124 cut-like homeobox 1 Rattus norvegicus 134-137 11269664-1 2001 We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline. Phosphatidylcholines 126-128 cut-like homeobox 1 Rattus norvegicus 134-137 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidylcholines 65-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11112525-2 2000 To probe mechanisms for membrane interactions and phosphatidylcholine binding, we expressed recombinant human PC-TP in Escherichia coli using a synthetic gene. Phosphatidylcholines 50-69 phosphatidylcholine transfer protein Homo sapiens 110-115 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 133-152 ATP binding cassette subfamily B member 4 Homo sapiens 101-105 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 133-152 ATP binding cassette subfamily B member 1 Homo sapiens 106-120 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 154-156 ATP binding cassette subfamily B member 4 Homo sapiens 101-105 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 154-156 ATP binding cassette subfamily B member 1 Homo sapiens 106-120 11007780-6 2000 Results obtained with phagocyte membrane vesicles can be reproduced fully by replacing these with partially purified cytochrome b(559), incorporated in phosphatidylcholine vesicles. Phosphatidylcholines 152-171 mitochondrially encoded cytochrome b Homo sapiens 117-129 11007780-7 2000 Prenylated, but not nonprenylated, Rac1 binds spontaneously to phagocyte membrane vesicles and also to artificial, protein-free, phosphatidylcholine vesicles, a process counteracted by GDP dissociation inhibitor for Rho. Phosphatidylcholines 129-148 Rac family small GTPase 1 Homo sapiens 35-39 11007780-9 2000 Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1. Phosphatidylcholines 135-154 inhibitor of growth family member 1 Homo sapiens 15-18 11007780-9 2000 Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1. Phosphatidylcholines 135-154 Rac family small GTPase 1 Homo sapiens 76-80 11007780-9 2000 Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1. Phosphatidylcholines 135-154 Rac family small GTPase 1 Homo sapiens 209-213 11112525-1 2000 Phosphatidylcholine transfer protein (PC-TP) is a 214-amino acid cytosolic protein that promotes intermembrane transfer of phosphatidylcholines, but no other phospholipid class. Phosphatidylcholines 123-143 phosphatidylcholine transfer protein Homo sapiens 0-36 11112525-1 2000 Phosphatidylcholine transfer protein (PC-TP) is a 214-amino acid cytosolic protein that promotes intermembrane transfer of phosphatidylcholines, but no other phospholipid class. Phosphatidylcholines 123-143 phosphatidylcholine transfer protein Homo sapiens 38-43 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11112525-10 2000 These studies suggest that tandem alpha-helices located near the C-terminus of PC-TP facilitate membrane binding and extraction of phosphatidylcholines. Phosphatidylcholines 131-151 phosphatidylcholine transfer protein Homo sapiens 79-84 11152958-4 2000 When phosphatidylcholine-specific phospholipase C (PC-PLC) was inhibited by D609, the Fas-induced changes in PLD activity, DAG content, and PKC translocation were inhibited. Phosphatidylcholines 5-24 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 11111093-2 2000 LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins. Phosphatidylcholines 55-75 lecithin-cholesterol acyltransferase Homo sapiens 0-4 11106499-2 2000 Our earlier studies demonstrated that high-density lipoproteins (HDLs) stimulate multiple signaling pathways, including activation of phosphatidylcholine-specific phospholipases C and D (PC-PLs) and phosphatidylinositol-specific phospholipase C (PI-PLC). Phosphatidylcholines 134-153 phospholipase C beta 1 Homo sapiens 246-252 11106499-15 2000 Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation. Phosphatidylcholines 19-38 apolipoprotein A1 Homo sapiens 0-5 11112443-6 2000 Finally, recombinant expression of hGIIF sPLA(2) in Escherichia coli shows that the enzyme is Ca(2+)-dependent, maximally active at pH 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. Phosphatidylcholines 183-202 phospholipase A2 group IIA Homo sapiens 41-48 11192332-5 2000 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction. Phosphatidylcholines 102-121 phosphatidylethanolamine N-methyltransferase Homo sapiens 11-53 11192332-5 2000 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction. Phosphatidylcholines 102-121 phosphatidylethanolamine N-methyltransferase Homo sapiens 55-59 11192332-5 2000 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction. Phosphatidylcholines 123-125 phosphatidylethanolamine N-methyltransferase Homo sapiens 11-53 11192332-5 2000 Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction. Phosphatidylcholines 123-125 phosphatidylethanolamine N-methyltransferase Homo sapiens 55-59 11108844-0 2000 Cholecystokinin octapeptide CCK-8 and carbachol reduce [(32)P]orthophosphate labeling of phosphatidylcholine without modifying phospholipase D activity in rat pancreatic acini. Phosphatidylcholines 89-108 cholecystokinin Rattus norvegicus 0-15 11108844-3 2000 However, the secretagogues cholecystokinin octapeptide and carbachol did not enhance basal accumulation of (32)P-phosphatidylalcohol, yet they decreased [(32)P]phosphatidylcholine content and stimulated the generation of [(32)P]phosphatidic acid. Phosphatidylcholines 160-179 cholecystokinin Rattus norvegicus 27-42 11152958-4 2000 When phosphatidylcholine-specific phospholipase C (PC-PLC) was inhibited by D609, the Fas-induced changes in PLD activity, DAG content, and PKC translocation were inhibited. Phosphatidylcholines 5-24 protein kinase C beta Homo sapiens 140-143 11108734-7 2000 In HepG2 cells, the expression of the human SR-BI homolog was reduced when the vitE content was increased by incubating the cells with vitE-loaded HDL or with phosphatidylcholine/vitE vesicles. Phosphatidylcholines 159-178 scavenger receptor class B member 1 Homo sapiens 44-49 11080206-10 2000 These data suggest multiple beneficial effects of CDP-choline: (1) stabilizing the cell membrane by restoring PtdCho and sphingomyelin (prominent components of outer cell membrane), (2) attenuating the release of ArAc and limiting its oxidative metabolism, and (3) restoring cardiolipin levels. Phosphatidylcholines 110-116 cut like homeobox 1 Homo sapiens 50-53 11108736-2 2000 Lecithin:retinol acyltransferase (LRAT), present in microsomes, catalyzes the transfer of the sn-1 fatty acid of phosphatidylcholine to retinol bound to a cellular retinol-binding protein. Phosphatidylcholines 113-132 lecithin retinol acyltransferase Rattus norvegicus 0-32 11108736-2 2000 Lecithin:retinol acyltransferase (LRAT), present in microsomes, catalyzes the transfer of the sn-1 fatty acid of phosphatidylcholine to retinol bound to a cellular retinol-binding protein. Phosphatidylcholines 113-132 lecithin retinol acyltransferase Rattus norvegicus 34-38 11093788-2 2000 Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression. Phosphatidylcholines 59-78 interleukin 1 beta Homo sapiens 132-140 11101661-7 2000 Unexpectedly, PC-PLC inhibited HBL lysis of sheep erythrocytes (<2% PC) and enhanced the discontinuous haemolysis pattern that is characteristic of HBL in sheep blood agar. Phosphatidylcholines 14-16 heparan sulfate proteoglycan 2 Homo sapiens 17-20 11093788-12 2000 Taken together, IL-1beta activates phosphatidylcholine-specific phospholipase C and induces activation of PKCalpha and protein tyrosine kinase, resulting in the stimulation of NIK, IKK2, and NF-kappaB in the ICAM-1 promoter, then initiation of ICAM-1 expression. Phosphatidylcholines 35-54 interleukin 1 beta Homo sapiens 16-24 11093788-2 2000 Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression. Phosphatidylcholines 59-78 intercellular adhesion molecule 1 Homo sapiens 149-155 11115895-1 2000 Saccharomyces cerevisiae opi3 mutant strains do not have the phospholipid N-methyltransferase that catalyzes the two terminal methylations in the phosphatidylcholine (PC) biosynthetic pathway. Phosphatidylcholines 146-165 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 25-29 11115895-1 2000 Saccharomyces cerevisiae opi3 mutant strains do not have the phospholipid N-methyltransferase that catalyzes the two terminal methylations in the phosphatidylcholine (PC) biosynthetic pathway. Phosphatidylcholines 167-169 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 25-29 10938271-3 2000 Taking advantage of the substrate specificity of PSS1, we showed that (i) MAM contain choline exchange activity, whereas this activity is very low in the bulk of the ER, (ii) serine exchange activity is inhibited by choline to a much greater extent in MAM than in ER, and (iii) MAM use phosphatidylcholine and phosphatidylethanolamine as substrates for phosphatidylserine biosynthesis, whereas the ER utilizes only phosphatidylethanolamine. Phosphatidylcholines 286-305 phosphatidylserine synthase 1 Cricetulus griseus 49-53 11082530-7 2000 A new molecular interaction model for the beta-sheet structure and phosphatidylcholine headgroups is introduced and an overall view of the tertiary structure of apolipoprotein B-100 in the LDL particles is presented. Phosphatidylcholines 67-86 apolipoprotein B Homo sapiens 161-181 10903316-8 2000 Consistently, in vitro biomolecular interaction between PS/phosphatidylethanolamine /phosphatidylcholine liposomes, and Raf-1 increased in a PS concentration-dependent manner. Phosphatidylcholines 85-104 v-raf-leukemia viral oncogene 1 Mus musculus 120-125 10944538-4 2000 Previous work by us showed that at early stages of FC loading, when macrophages are still healthy, there is activation of the phosphatidylcholine (PC) biosynthetic enzyme, CTP:phosphocholine cytidylyltransferase (CT), and accumulation of PC mass. Phosphatidylcholines 126-145 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 172-211 11053135-0 2000 PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study. Phosphatidylcholines 106-125 proteolipid ATPase Saccharomyces cerevisiae S288C 0-4 11009606-0 2000 (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain. Phosphatidylcholines 47-66 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 0-35 11099795-4 2000 Colipase, a surface-active cofactor of lipase, relieves inhibition by phosphatidylcholine in several ways. Phosphatidylcholines 70-89 colipase Homo sapiens 0-45 11053518-1 2000 An aqueous extract of Platycodi radix inhibited the hydrolysis of triolein emulsified with phosphatidylcholine by pancreatic lipase in vitro and it reduced the elevation of rat plasma triacylglycerol level 2-4 h after oral administration of a lipid emulsion containing corn oil. Phosphatidylcholines 91-110 lipase G, endothelial type Rattus norvegicus 125-131 11080676-3 2000 gVPLA(2) is homologous to other group II PLA(2) family members but has distinctive enzymatic properties, including its activity to effectively hydrolyze phosphatidylcholine (PC) vesicles and the outer plasma membrane of mammalian cells. Phosphatidylcholines 153-172 phospholipase A2 group V Homo sapiens 0-8 11080676-3 2000 gVPLA(2) is homologous to other group II PLA(2) family members but has distinctive enzymatic properties, including its activity to effectively hydrolyze phosphatidylcholine (PC) vesicles and the outer plasma membrane of mammalian cells. Phosphatidylcholines 153-172 phospholipase A2 group IB Homo sapiens 2-8 11080676-4 2000 Mutational studies showed that gVPLA(2) has a unique structure that allows effective binding to PC membranes and efficient catalysis of an active-site-bound PC substrate. Phosphatidylcholines 96-98 phospholipase A2 group V Homo sapiens 31-39 11080676-4 2000 Mutational studies showed that gVPLA(2) has a unique structure that allows effective binding to PC membranes and efficient catalysis of an active-site-bound PC substrate. Phosphatidylcholines 157-159 phospholipase A2 group V Homo sapiens 31-39 11023832-2 2000 The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha. Phosphatidylcholines 85-104 CD34 molecule Homo sapiens 188-192 11023832-2 2000 The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha. Phosphatidylcholines 85-104 CD38 molecule Homo sapiens 196-200 11023832-2 2000 The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha. Phosphatidylcholines 85-104 tumor necrosis factor Homo sapiens 218-226 11015229-2 2000 Comparison of the positional dependences of the spectral data for the two series of spin-labeled lipids suggests that the N-acyl chain is positioned at approximately the same level as the sn-2 chain of the phosphatidylcholine spin-label. Phosphatidylcholines 206-225 spindlin 1 Homo sapiens 84-88 11015229-2 2000 Comparison of the positional dependences of the spectral data for the two series of spin-labeled lipids suggests that the N-acyl chain is positioned at approximately the same level as the sn-2 chain of the phosphatidylcholine spin-label. Phosphatidylcholines 206-225 spindlin 1 Homo sapiens 226-230 11015229-3 2000 Further, similar conclusions are reached when the ESR spectra of the N-acyl PE spin-labels in dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylethanolamine (DMPE) host matrixes are compared with those of phosphatidylcholine spin-labels in these two lipids. Phosphatidylcholines 105-124 spindlin 1 Homo sapiens 79-83 11009606-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 119-138 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 11009606-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 140-142 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 0-35 11009606-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 140-142 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. Phosphatidylcholines 131-133 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 29-32 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. Phosphatidylcholines 131-133 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 34-47 11060354-7 2000 We also demonstrated that organic cation transport by mOct1/Slc22a1 is inhibited by several organic cations, and that the gene is expressed in the perinatal period, at a time when phosphatidylcholine synthesis increases. Phosphatidylcholines 180-199 solute carrier family 22 (organic cation transporter), member 1 Mus musculus 54-59 11060354-7 2000 We also demonstrated that organic cation transport by mOct1/Slc22a1 is inhibited by several organic cations, and that the gene is expressed in the perinatal period, at a time when phosphatidylcholine synthesis increases. Phosphatidylcholines 180-199 solute carrier family 22 member 1 Homo sapiens 60-67 11052674-3 2000 Phospholipid vesicles composed of PE, phosphatidylserine (PS), and phosphatidylcholine support factor Xa generation. Phosphatidylcholines 67-86 coagulation factor X Homo sapiens 95-104 11009606-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 119-138 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 0-35 11129952-6 2000 The mechanism for the reduction in radiolabelled fatty acid incorporation into phosphatidylcholine was a 64% (p < 0.05) reduction in membrane phospholipase A2 activity. Phosphatidylcholines 79-98 phospholipase A2 group IB Homo sapiens 145-161 11012677-4 2000 Our differential scanning calorimetry results reveal that P17 slightly perturbs the phase behaviour of neutral phosphatidylcholine and negatively charged multilamellar vesicles. Phosphatidylcholines 111-130 assembly Enterobacteria phage PRD1 58-61 11000525-2 2000 To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 10889195-4 2000 The bovine LDL receptor has been purified and reconstituted into egg yolk phosphatidylcholine vesicle bilayers. Phosphatidylcholines 74-93 low density lipoprotein receptor Bos taurus 11-23 11000525-2 2000 To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned. Phosphatidylcholines 32-51 phospholipase D1 Homo sapiens 86-91 11000525-2 2000 To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned. Phosphatidylcholines 32-51 phospholipase D2 Homo sapiens 96-101 11018472-1 2000 Our previous studies have shown that parathyroid hormone (PTH) stimulates phosphatidylcholine (PC) hydrolysis by phospholipase D (PLD) and transphosphatidylation in UMR-106 osteoblastic cells. Phosphatidylcholines 95-97 parathyroid hormone Rattus norvegicus 37-56 11018469-0 2000 Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis. Phosphatidylcholines 208-227 receptor for activated C kinase 1 Mus musculus 35-66 10893425-1 2000 A cholinephosphotransferase activity catalyzes the final step in the de novo synthesis of phosphatidylcholine via the transfer of a phosphocholine moiety from CDP choline to diacylglycerol. Phosphatidylcholines 90-109 cut like homeobox 1 Homo sapiens 159-162 11018469-0 2000 Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis. Phosphatidylcholines 208-227 receptor for activated C kinase 1 Mus musculus 68-73 11018469-2 2000 Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1. Phosphatidylcholines 52-71 Phospholipase D Drosophila melanogaster 107-110 11018469-2 2000 Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1. Phosphatidylcholines 73-79 Phospholipase D Drosophila melanogaster 107-110 11018469-2 2000 Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1. Phosphatidylcholines 73-79 Phospholipase D Drosophila melanogaster 217-220 11018469-2 2000 Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1. Phosphatidylcholines 73-79 Receptor of activated protein kinase C 1 Drosophila melanogaster 318-323 11018469-8 2000 The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts. Phosphatidylcholines 293-299 Phospholipase D Drosophila melanogaster 44-47 11018469-8 2000 The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts. Phosphatidylcholines 293-299 Receptor of activated protein kinase C 1 Drosophila melanogaster 124-129 11018472-1 2000 Our previous studies have shown that parathyroid hormone (PTH) stimulates phosphatidylcholine (PC) hydrolysis by phospholipase D (PLD) and transphosphatidylation in UMR-106 osteoblastic cells. Phosphatidylcholines 74-93 parathyroid hormone Rattus norvegicus 37-56 10889208-2 2000 We have investigated the basis for the protein substrate specificity of Xase using TF reconstituted into vesicles of phosphatidylcholine, phosphatidylserine, or pure phosphatidylcholine. Phosphatidylcholines 117-136 coagulation factor III, tissue factor Homo sapiens 83-85 11045596-7 2000 However, the phosphatidylcholine (PC)-specific phospholipase C (PLC) inhibitor D609 decreased the KCN-induced IL-1alpha mRNA and protein in PC12 cells suggests that PC-PLC might play a role in cytokine induction during hypoxia. Phosphatidylcholines 13-32 interleukin 1 alpha Rattus norvegicus 110-119 11045596-7 2000 However, the phosphatidylcholine (PC)-specific phospholipase C (PLC) inhibitor D609 decreased the KCN-induced IL-1alpha mRNA and protein in PC12 cells suggests that PC-PLC might play a role in cytokine induction during hypoxia. Phosphatidylcholines 34-36 interleukin 1 alpha Rattus norvegicus 110-119 10964416-6 2000 Catalytically, DAGK showed a strong preference for bicelles containing 3-(cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate (CHAPSO) as the detergentcomponent relative to short-chained phosphatidylcholine.DAGK also exhibited a preference for dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine bicelles relative to those of dilauroylphosphatidylcholine. Phosphatidylcholines 196-215 diacylglycerol kinase alpha Homo sapiens 15-19 10973618-0 2000 Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes. Phosphatidylcholines 25-44 adrenomedullin Rattus norvegicus 0-14 11033981-6 2000 RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine. Phosphatidylcholines 137-156 pancreatic lipase Mus musculus 60-77 10973618-4 2000 Adrenomedullin increased the secretion of phosphatidylcholine, the predominant component of pulmonary surfactant, by type II pneumocytes. Phosphatidylcholines 42-61 adrenomedullin Rattus norvegicus 0-14 10973866-15 2000 01) between plasma PLTP and plasma phosphatidylcholine transfer activity (range, 3.5-10.5 micromol. Phosphatidylcholines 35-54 phospholipid transfer protein Homo sapiens 19-23 10973058-1 2000 Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5"-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT). Phosphatidylcholines 0-19 CCT Homo sapiens 146-149 10973058-1 2000 Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5"-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT). Phosphatidylcholines 21-23 CCT Homo sapiens 146-149 10973058-3 2000 The membrane-binding domain of CCT is a long amphipathic alpha helix that responds to changes in the physical properties of PC-deficient membranes. Phosphatidylcholines 124-126 CCT Homo sapiens 31-34 10852916-11 2000 PLD2 regulates the breakdown of phosphatidylcholine and has been implicated in vesicular trafficking. Phosphatidylcholines 32-51 phospholipase D2 Homo sapiens 0-4 10956052-0 2000 Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol. Phosphatidylcholines 71-90 apolipoprotein A1 Homo sapiens 52-70 10956052-0 2000 Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol. Phosphatidylcholines 190-209 apolipoprotein A1 Homo sapiens 52-70 10956052-5 2000 In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC). Phosphatidylcholines 153-172 apolipoprotein A1 Homo sapiens 110-128 10956052-5 2000 In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC). Phosphatidylcholines 153-172 apolipoprotein A1 Homo sapiens 130-136 10956052-5 2000 In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC). Phosphatidylcholines 174-176 apolipoprotein A1 Homo sapiens 110-128 10956052-5 2000 In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC). Phosphatidylcholines 174-176 apolipoprotein A1 Homo sapiens 130-136 10956052-6 2000 Ethanol significantly inhibited binding of PC to apoA-I, inhibited incorporation of cholesterol only when apoA-I contained PC, and did not alter incorporation of cholesterol into HDL. Phosphatidylcholines 43-45 apolipoprotein A1 Homo sapiens 49-55 10956052-6 2000 Ethanol significantly inhibited binding of PC to apoA-I, inhibited incorporation of cholesterol only when apoA-I contained PC, and did not alter incorporation of cholesterol into HDL. Phosphatidylcholines 123-125 apolipoprotein A1 Homo sapiens 106-112 10956053-4 2000 Formation of the complex between G(t) and photoactivated rhodopsin reconstituted into phosphatidylcholine vesicles caused prominent infrared absorption increases at 1641, 1550, and 1517 cm(-)(1). Phosphatidylcholines 86-105 rhodopsin Homo sapiens 57-66 10843997-2 2000 Transient expression of ARF-1(T31N), a GDP-restrictive mutant, significantly inhibited apolipoprotein B-100 (apoB-100) VLDL production without influencing the biosynthesis of apoB-100 low density lipoproteins or total apoB production (indicating that it inhibited the second step of VLDL assembly) and without altering total protein production or biosynthesis of transferrin, phosphatidylcholine, or triglycerides. Phosphatidylcholines 376-395 ADP-ribosylation factor 1 Rattus norvegicus 24-29 10933785-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 115-134 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 11004609-0 2000 Arachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytes. Phosphatidylcholines 28-47 interleukin 2 Rattus norvegicus 96-109 11004609-0 2000 Arachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytes. Phosphatidylcholines 28-47 interferon gamma Rattus norvegicus 114-130 10933785-1 2000 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 136-138 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 10827200-7 2000 Analysis of molecular species of microsomal phosphatidylcholine and phosphatidylethanolamine by electron spray tandem mass spectrometry revealed that the enrichment of oleoyl moieties was altered by the treatment of iPLA(2) antagonist. Phosphatidylcholines 44-63 phospholipase A2 group VI Rattus norvegicus 216-223 10972869-8 2000 Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate. Phosphatidylcholines 149-168 patatin-like protein 2 Nicotiana tabacum 12-18 10918072-2 2000 The MDR3 P-glycoprotein is a transmembrane protein that translocates phosphatidylcholine. Phosphatidylcholines 69-88 ATP binding cassette subfamily B member 4 Homo sapiens 4-8 10918072-2 2000 The MDR3 P-glycoprotein is a transmembrane protein that translocates phosphatidylcholine. Phosphatidylcholines 69-88 ATP binding cassette subfamily B member 1 Homo sapiens 9-23 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 ATP binding cassette subfamily B member 1 Homo sapiens 5-19 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 ATP binding cassette subfamily B member 4 Homo sapiens 210-214 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 phosphoglycolate phosphatase Homo sapiens 215-219 10946014-1 2000 The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated. Phosphatidylcholines 25-44 vascular cell adhesion molecule 1 Homo sapiens 100-133 10946014-1 2000 The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated. Phosphatidylcholines 25-44 vascular cell adhesion molecule 1 Homo sapiens 135-141 10946014-1 2000 The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated. Phosphatidylcholines 46-48 vascular cell adhesion molecule 1 Homo sapiens 100-133 10946014-1 2000 The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated. Phosphatidylcholines 46-48 vascular cell adhesion molecule 1 Homo sapiens 135-141 11055744-4 2000 The incubation of LA-N-1 nuclei with radioactive choline, phosphocholine or CDP-choline led to the production of labelled phosphatidylcholine. Phosphatidylcholines 122-141 cut like homeobox 1 Homo sapiens 76-79 10931974-2 2000 CAP18 intercalates into lipid matrices composed of LPS from sensitive strains, weaker into those made of LPS from a resistant strain (Proteus mirabilis strain R45) or negatively charged phospholipids, but not into those composed of neutral phosphatidylcholine. Phosphatidylcholines 240-259 antimicrobial protein CAP18 Oryctolagus cuniculus 0-5 10972869-8 2000 Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate. Phosphatidylcholines 149-168 patatin-like protein 3 Nicotiana tabacum 23-29 10972869-8 2000 Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate. Phosphatidylcholines 149-168 phospholipase A2 group IB Homo sapiens 132-136 10941873-4 2000 L-FABP expression increased the masses of choline glycerophospholipids (ChoGpl) 1.5-fold, phosphatidylserine (PtdSer) 5.6-fold, ethanolamine glycerophospholipids 1.4-fold, sphingomyelin 1.7-fold, and phosphatidylinositol 2.6-fold. Phosphatidylcholines 72-78 fatty acid binding protein 1 Homo sapiens 0-6 11040375-5 2000 Pyrene labeled phosphatidylcholine was added to 50 microg of cytosolic protein in Tris buffer (pH 8.0) containing fatty acid free-bovine serum albumin for a final assay volume of 2 ml. Phosphatidylcholines 15-34 albumin Mus musculus 137-150 10801835-3 2000 Phosphorylation of charge isomers of recombinant mouse PI-TPalpha confirmed that the PC-containing isomer was the better substrate. Phosphatidylcholines 85-87 phosphatidylinositol transfer protein, alpha Mus musculus 55-65 10801878-4 2000 270, 16277-16282) showed that expression of wild-type CT-alpha rescued the cells at 40 degrees C, whereas expression of phosphatidylethanolamine N-methyltransferase-2 (PEMT2) did not, even though PC levels appeared to be maintained at wild-type levels after 24 h at the restrictive temperature. Phosphatidylcholines 196-198 choline-phosphate cytidylyltransferase A Cricetulus griseus 54-62 10933130-10 2000 Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates. Phosphatidylcholines 54-73 surfactant protein C Homo sapiens 75-80 10933130-10 2000 Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates. Phosphatidylcholines 54-73 cytochrome c oxidase subunit 8A Homo sapiens 135-139 10748000-8 2000 We conclude that GH rapidly increases the beta-cell cytoplasmic free [Ca(2+)] and also evokes a similar increase in DAG content via a phosphatidylcholine-specific phospholipase C, but does not affect mitogen-activated protein kinases, phospholipase D, or the cAMP signaling pathway. Phosphatidylcholines 134-153 growth hormone 1 Homo sapiens 17-19 10921856-1 2000 We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques. Phosphatidylcholines 170-189 tachykinin precursor 1 Homo sapiens 73-84 10921856-1 2000 We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques. Phosphatidylcholines 191-193 tachykinin precursor 1 Homo sapiens 73-84 10918482-4 2000 Egg yolk phosphatidylcholine- and dipalmitoylphosphatidylcholine-based PCL were as effective as dioleoylphosphatidylethanolamine-based PCLs for gene transfer. Phosphatidylcholines 9-28 polycystic kidney disease 2-like 1 Mus musculus 71-74 10873602-5 2000 Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM). Phosphatidylcholines 69-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 10777500-9 2000 Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-13 10777500-9 2000 Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion. Phosphatidylcholines 48-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-13 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 59-63 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 65-69 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 94-98 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 248-251 10873602-5 2000 Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM). Phosphatidylcholines 69-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 10837365-6 2000 The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression. Phosphatidylcholines 135-154 tumor necrosis factor Homo sapiens 218-227 10839997-2 2000 We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells. Phosphatidylcholines 33-52 phospholipase A2 group V Homo sapiens 15-23 10839997-2 2000 We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells. Phosphatidylcholines 33-52 phospholipase A2 group IIA Homo sapiens 17-23 10839997-2 2000 We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells. Phosphatidylcholines 77-96 phospholipase A2 group V Homo sapiens 15-23 10839997-2 2000 We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells. Phosphatidylcholines 77-96 phospholipase A2 group IIA Homo sapiens 17-23 10839997-3 2000 To understand the molecular basis of the high phosphatidylcholine specificity of hVPLA(2), we mutated several residues (Gly-53, Glu-56 and Glu-57) that might be involved in interaction with an active-site-bound phospholipid molecule. Phosphatidylcholines 46-65 phospholipase A2 group V Homo sapiens 81-89 10839997-6 2000 Together, these steric and electrostatic properties of the active site of hVPLA(2) allow for effective binding and hydrolysis of a bulky cationic choline head group of phosphatidylcholine, which is unique among mammalian secretory PLA(2)s. Phosphatidylcholines 168-187 phospholipase A2 group V Homo sapiens 74-82 10839997-6 2000 Together, these steric and electrostatic properties of the active site of hVPLA(2) allow for effective binding and hydrolysis of a bulky cationic choline head group of phosphatidylcholine, which is unique among mammalian secretory PLA(2)s. Phosphatidylcholines 168-187 phospholipase A2 group IIA Homo sapiens 231-238 10873862-4 2000 PLD also catalyses a transphosphatidylation reaction in the presence of phosphatidylcholine and a short-chained primary or secondary alcohol. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 10845833-2 2000 Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD). Phosphatidylcholines 0-20 superoxide dismutase 1 Homo sapiens 27-30 10845833-2 2000 Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD). Phosphatidylcholines 0-20 superoxide dismutase 1 Homo sapiens 35-38 10845833-2 2000 Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD). Phosphatidylcholines 0-20 superoxide dismutase 1 Homo sapiens 35-38 10856534-3 2000 Such an investigation was important because Lp-PLA(2) participates in the oxidative modification of low density lipoprotein by cleaving oxidised phosphatidylcholines, generating lysophosphatidylcholine and oxidised free fatty acids. Phosphatidylcholines 145-165 phospholipase A2 group VII Homo sapiens 44-53 10827979-6 2000 The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+). Phosphatidylcholines 52-71 procollagen C-endopeptidase enhancer Homo sapiens 140-148 10827979-6 2000 The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+). Phosphatidylcholines 73-75 procollagen C-endopeptidase enhancer Homo sapiens 140-148 10860542-10 2000 The inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), D609 (100 microM), decreased fMLP-mediated AA release by approximately 35%. Phosphatidylcholines 17-36 formyl peptide receptor 1 Homo sapiens 101-105 10861856-3 2000 Previous work from this laboratory using pharmacologic agents suggested that a phosphatidylcholine-specific phospholipase C and protein kinase C may be involved in early aspects of TGF-beta signaling. Phosphatidylcholines 79-98 transforming growth factor beta 1 Homo sapiens 181-189 10835321-4 2000 At 1-2 days of age, lung saturated phosphatidylcholine (Sat PC) pool sizes were higher in wild-type, beta(c)(-/-), and GM(-/-) mice compared with wild-type adult mice. Phosphatidylcholines 35-54 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Mus musculus 101-108 10843891-1 2000 Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates. Phosphatidylcholines 250-269 prothrombin Oryctolagus cuniculus 0-8 10843891-1 2000 Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates. Phosphatidylcholines 250-269 phospholipase A2 Oryctolagus cuniculus 104-122 10843891-1 2000 Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates. Phosphatidylcholines 250-269 phospholipase A2 Oryctolagus cuniculus 124-130 10845873-5 2000 Consistent with the reduction in cholesterol and phospholipid efflux in Tangier fibroblasts, downregulation of ABC1 expression by IFN-gamma also resulted in reduced phosphatidylcholine and sphingomyelin efflux to apolipoprotein A-I. Phosphatidylcholines 165-184 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 111-115 10845873-5 2000 Consistent with the reduction in cholesterol and phospholipid efflux in Tangier fibroblasts, downregulation of ABC1 expression by IFN-gamma also resulted in reduced phosphatidylcholine and sphingomyelin efflux to apolipoprotein A-I. Phosphatidylcholines 165-184 interferon gamma Mus musculus 130-139 10837365-6 2000 The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression. Phosphatidylcholines 135-154 tumor necrosis factor Homo sapiens 338-347 10837365-6 2000 The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression. Phosphatidylcholines 135-154 intercellular adhesion molecule 1 Homo sapiens 363-369 10799527-0 2000 A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14. Phosphatidylcholines 169-188 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 87-92 10828088-9 2000 One of the PAF-like PC with an aldehydic terminal was found to be bioactive; it inhibited the production of nitric oxide induced by lipopolysaccharide and interferon-gamma in vascular smooth muscle cells from rat aorta. Phosphatidylcholines 20-22 interferon gamma Rattus norvegicus 155-171 10809752-6 2000 The GM3-dependent c-Src phosphorylation response was enhanced when cholesterol and phosphatidylcholine were added. Phosphatidylcholines 83-102 granulocyte macrophage antigen 3 Mus musculus 4-7 11401344-1 2000 The adsorption of lysozyme and cytochrome C on phosphatidylcholine liposomes essentially changes the physical properties of the phospholipid membranes and under certain circumstances greatly affects the stability of the colloid dispersion by inducing bridging liposome flocculation. Phosphatidylcholines 47-66 lysozyme Homo sapiens 18-26 11401344-1 2000 The adsorption of lysozyme and cytochrome C on phosphatidylcholine liposomes essentially changes the physical properties of the phospholipid membranes and under certain circumstances greatly affects the stability of the colloid dispersion by inducing bridging liposome flocculation. Phosphatidylcholines 47-66 cytochrome c, somatic Homo sapiens 31-43 10848624-4 2000 Yet, SFH proteins sharing low primary sequence similarity with Sec14p (i.e., Sfh2p, Sfh3p, Sfh4p, and Sfh5p) represent novel phosphatidylinositol transfer proteins (PITPs) that exhibit phosphatidylinositol- but not phosphatidylcholine-transfer activity in vitro. Phosphatidylcholines 215-234 Csr1p Saccharomyces cerevisiae S288C 77-82 10799527-0 2000 A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14. Phosphatidylcholines 169-188 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 207-212 10799527-5 2000 The PSTB2 gene is allelic to the pleiotropic drug resistance gene, PDR17, and is homologous to SEC14, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein. Phosphatidylcholines 139-158 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 67-72 10799527-5 2000 The PSTB2 gene is allelic to the pleiotropic drug resistance gene, PDR17, and is homologous to SEC14, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein. Phosphatidylcholines 139-158 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 95-100 10760824-1 2000 Phosphatidylethanolamine N-methyltransferase(PEMT) is an enzyme in liver that catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Phosphatidylcholines 144-163 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 45-49 10887963-3 2000 Here, we have studied the effects of increasing concentrations of bovine MBP charge isomer C1 (MBP/C1) on large unilamellar vesicles (LUVs) composed of phosphatidylcholine and phosphatidylserine (92:8 molar ratio), or with a lipid composition similar to that of the myelin membrane in vivo (Cyt-LUVs). Phosphatidylcholines 152-171 myelin basic protein Bos taurus 73-76 10887963-3 2000 Here, we have studied the effects of increasing concentrations of bovine MBP charge isomer C1 (MBP/C1) on large unilamellar vesicles (LUVs) composed of phosphatidylcholine and phosphatidylserine (92:8 molar ratio), or with a lipid composition similar to that of the myelin membrane in vivo (Cyt-LUVs). Phosphatidylcholines 152-171 myelin basic protein Bos taurus 95-98 10760824-1 2000 Phosphatidylethanolamine N-methyltransferase(PEMT) is an enzyme in liver that catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Phosphatidylcholines 214-233 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 45-49 10744775-0 2000 Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity. Phosphatidylcholines 0-19 lecithin-cholesterol acyltransferase Homo sapiens 50-86 11200461-2 2000 These changes are conditioned by activation of phospholipase A2, which catalyses the deacylation of PL-glycerides predominantly phosphatidylcholines with the formation of high concentrations of lysophosphatidylcholines. Phosphatidylcholines 128-148 phospholipase A2 group IB Rattus norvegicus 47-63 10757993-7 2000 Nevertheless, aqueous TMX-1 partitioned strongly into membrane vesicles with apparent mole-fraction free-energy values of -7.1 kcal mol(-1) for phosphatidylcholine (POPC) vesicles and -8.2 kcal mol(-1) for phosphatidylglycerol (POPG) vesicles. Phosphatidylcholines 144-163 thioredoxin related transmembrane protein 1 Homo sapiens 22-27 10717249-9 2000 These are phosphatidylinositol-4, 5-bisphosphate-specific phospholipase C and phosphatidylethanolamine-specific phospholipase D. A positive feedback mechanism for DG production which includes these phospholipases, a phosphatidylcholine-specific phospholipase C and a phosphatidylcholine-specific phospholipase A2 has also been suggested. Phosphatidylcholines 216-235 phospholipase A2 group IB Homo sapiens 296-312 10764624-13 2000 In contrast, PFDA-treated rats showed a preference for ethanolamine, and PtdC was predominately synthesized through the PEMT pathway. Phosphatidylcholines 73-77 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 120-124 10744775-6 2000 Even though fluidity was similar among the PC ether-containing rHDL, the order of PC reactivity with LCAT was significantly correlated (r(2) = 0.71) with that of 100% PC rHDL containing the same 18 carbon sn-2 fatty acyl chain species, suggesting that PC structure in the active site of LCAT determines reactivity in the absence of measurable differences in bilayer fluidity. Phosphatidylcholines 82-84 lecithin-cholesterol acyltransferase Homo sapiens 101-105 10888232-5 2000 Since phosphatidylcholine is metabolized mainly by the action of phospholipase A2, with the release of arachidonic acid and other fatty acids, the effect of phosphocholine on arachidonic acid release in endothelial cells was also examined. Phosphatidylcholines 6-25 phospholipase A2 group IB Homo sapiens 65-81 10734122-1 2000 We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12). Phosphatidylcholines 128-147 tumor necrosis factor Mus musculus 31-58 10734122-1 2000 We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12). Phosphatidylcholines 128-147 tumor necrosis factor Mus musculus 60-68 10734122-1 2000 We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12). Phosphatidylcholines 149-155 tumor necrosis factor Mus musculus 31-58 10734122-1 2000 We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12). Phosphatidylcholines 149-155 tumor necrosis factor Mus musculus 60-68 10734122-7 2000 Addition of N-acetyl-Leu-Leu-Nle-CHO (ALLN), the calpain I inhibitor, or lactacystin, the 20 S proteasome inhibitor, blocked the inhibition of PtdCho biosynthesis mediated by TNFalpha. Phosphatidylcholines 143-149 tumor necrosis factor Mus musculus 175-183 10734122-11 2000 Thus, TNFalpha inhibits PtdCho synthesis by modulating CCT protein stability via the ubiquitin-proteasome and calpain-mediated proteolytic pathways. Phosphatidylcholines 24-30 tumor necrosis factor Mus musculus 6-14 10734122-11 2000 Thus, TNFalpha inhibits PtdCho synthesis by modulating CCT protein stability via the ubiquitin-proteasome and calpain-mediated proteolytic pathways. Phosphatidylcholines 24-30 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 55-58 10720470-5 2000 Moreover, the rate of oxidation of pure phosphatidylcholine by Mb-H was found to be at least sevenfold greater than that observed for native myoglobin. Phosphatidylcholines 40-59 myoglobin Homo sapiens 141-150 10744786-5 2000 The AOFA transfer rate from phosphatidylcholine-containing vesicles (POPC) to L-FABP is similar to that observed with another diffusional process, namely inter-membrane AOFA transfer. Phosphatidylcholines 28-47 fatty acid binding protein 1 Homo sapiens 78-84 10744775-6 2000 Even though fluidity was similar among the PC ether-containing rHDL, the order of PC reactivity with LCAT was significantly correlated (r(2) = 0.71) with that of 100% PC rHDL containing the same 18 carbon sn-2 fatty acyl chain species, suggesting that PC structure in the active site of LCAT determines reactivity in the absence of measurable differences in bilayer fluidity. Phosphatidylcholines 82-84 lecithin-cholesterol acyltransferase Homo sapiens 287-291 10751643-4 2000 Supplementation of THP-1 with AA (25 microM, 1 week) or EPA (25 microM, 1 week) led to their efficient incorporation, in comparable quantities and with similar distributions, into phosphatidylcholine and phosphatidylethanolamine, and to a lesser extent into phosphatidylinositol. Phosphatidylcholines 180-199 GLI family zinc finger 2 Homo sapiens 19-24 10702314-7 2000 The treatment with phosphatidylcholine-specific phospholipase C (PC-PLC) inhibited macrophage proliferation, induced the expression of cytokines, and triggered a pattern of ERK activation equivalent to that induced by LPS. Phosphatidylcholines 19-38 mitogen-activated protein kinase 1 Homo sapiens 173-176 10706593-1 2000 Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells. Phosphatidylcholines 59-78 choline kinase beta Mus musculus 0-27 10706593-1 2000 Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells. Phosphatidylcholines 59-78 choline kinase beta Mus musculus 29-34 10692455-2 2000 The photosystem II core dimers were treated with phospholipase A2 (PL-A2), which cuts phosphatidylglycerol (PG) and phosphatidylcholine molecules at the sn-2 position. Phosphatidylcholines 116-135 phospholipase A2 group IB Homo sapiens 49-65 10692455-2 2000 The photosystem II core dimers were treated with phospholipase A2 (PL-A2), which cuts phosphatidylglycerol (PG) and phosphatidylcholine molecules at the sn-2 position. Phosphatidylcholines 116-135 phospholipase A2 group IB Homo sapiens 67-72 10754262-3 2000 In this study LC-MS of phosphatidylcholines in human LDL treated either with HOCl or the myeloperoxidase system was used as a specific method to detect chlorohydrin and peroxide formation simultaneously, and with comparable sensitivity. Phosphatidylcholines 23-43 myeloperoxidase Homo sapiens 89-104 10693931-4 2000 Our results showed that exogenously added apoE promoted the efflux of cholesterol and phosphatidylcholine from both astrocytes and neurons in culture, resulting in the generation of high-density lipoprotein-like particles. Phosphatidylcholines 86-105 apolipoprotein E Homo sapiens 42-46 10693931-7 2000 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 80-84 10693931-7 2000 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 182-186 10693931-7 2000 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines 48-67 LDL receptor related protein 1 Homo sapiens 283-286 10684648-4 2000 We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS). Phosphatidylcholines 232-251 apolipoprotein H Homo sapiens 75-85 10684648-4 2000 We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS). Phosphatidylcholines 253-255 apolipoprotein H Homo sapiens 75-85 10737702-2 2000 All myeloma cell lines express a PAF acetylhydrolase activity and metabolize [3H]PAF and [3H]lyso PAF in 1-alkyl-2-acyl analogue of phosphatidylcholine. Phosphatidylcholines 132-151 PCNA clamp associated factor Homo sapiens 33-36 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-107 10677235-0 2000 Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid. Phosphatidylcholines 72-91 mucin 7, secreted Homo sapiens 0-3 10677235-0 2000 Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid. Phosphatidylcholines 72-91 arachidonate 5-lipoxygenase Homo sapiens 15-29 10666121-8 2000 Selective expression of SP-D in the respiratory epithelium had no adverse effects on lung function, correcting surfactant phospholipid content and decreasing phosphatidylcholine incorporation significantly. Phosphatidylcholines 158-177 surfactant associated protein D Mus musculus 24-28 10666123-14 2000 Third, HGF is capable of significantly inhibiting the synthesis and secretion of the phosphatidylcholines of pulmonary surfactant. Phosphatidylcholines 85-105 hepatocyte growth factor Homo sapiens 7-10 10666123-15 2000 Fourth, HGF inhibits the rate-limiting enzyme in de novo phosphatidylcholine synthesis, CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15). Phosphatidylcholines 57-76 hepatocyte growth factor Homo sapiens 8-11 10666123-16 2000 Our data indicate that fibroblast-derived HGF could be partially responsible for the changes in surfactant dysfunction seen in adult respiratory distress syndrome, including the decreases seen in surfactant phosphatidylcholines. Phosphatidylcholines 207-227 hepatocyte growth factor Homo sapiens 42-45 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 10842920-7 2000 The Fourier transform-infrared (FT-IR) study indicated in comparison with the model compounds that the CCl4-injected rats accumulated DAG in addition to phosphatidylcholine, phosphatidylethanolamine and triglyceride (TG) in the lipid membrane fraction of the liver homogenate. Phosphatidylcholines 153-172 C-C motif chemokine ligand 4 Rattus norvegicus 103-107 10612714-6 2000 Phospholipid hydrolysis is less dependent on activator than triglycerides hydrolysis (100% and 300% of increase with apo CII for phosphatidyl-choline and triglycerides respectively). Phosphatidylcholines 129-149 apolipoprotein C2 Bos taurus 117-124 10821420-2 2000 The stimulatory effect of lipopolysaccharide on phosphatidylcholine secretion was additive to those of terbutaline and TPA (protein kinase A and C activators respectively) and this effect was not suppressed by inhibitors of both protein kinases. Phosphatidylcholines 48-67 plasminogen activator, tissue type Rattus norvegicus 119-122 10821420-2 2000 The stimulatory effect of lipopolysaccharide on phosphatidylcholine secretion was additive to those of terbutaline and TPA (protein kinase A and C activators respectively) and this effect was not suppressed by inhibitors of both protein kinases. Phosphatidylcholines 48-67 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 124-140 11996112-5 2000 Electrospray mass spectrometry provided direct evidence that chlorohydrins rather than peroxides are the major products of HOCl- or MPO-treated LDL phosphatidylcholines. Phosphatidylcholines 148-168 myeloperoxidase Homo sapiens 132-135 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidylcholines 173-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 127-142 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidylcholines 173-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 144-147 10625607-2 2000 The difference between spectra recorded in the presence and absence of agonist from the nAChR reconstituted into 3:1:1 egg phosphatidylcholine (EPC)/DOPA/Chol membranes exhibits positive and negative bands that serve as markers of the structural changes associated with the resting to desensitized conformational change. Phosphatidylcholines 123-142 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 88-93 10642356-4 2000 Cells isolated from rats given TNF-alpha had 26% lower levels of phosphatidylcholine compared with control. Phosphatidylcholines 65-84 tumor necrosis factor Rattus norvegicus 31-40 11237195-4 2000 These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF. Phosphatidylcholines 13-15 PCNA clamp associated factor Homo sapiens 231-257 11237195-4 2000 These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF. Phosphatidylcholines 13-15 PCNA clamp associated factor Homo sapiens 259-262 11237195-4 2000 These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF. Phosphatidylcholines 13-15 PCNA clamp associated factor Homo sapiens 308-311 10898226-2 2000 Recently, we reported that lysophosphatidylcholine (L-PC), the PLA2 hydrolysis product of phosphatidylcholine (PC), stimulates bacterial translocation (BT) in an enterocyte cell-culture model. Phosphatidylcholines 31-50 phospholipase A2 group IIA Homo sapiens 63-67 10617676-3 2000 The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect. Phosphatidylcholines 68-87 interleukin 1 beta Homo sapiens 132-140 10617676-3 2000 The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect. Phosphatidylcholines 68-87 prostaglandin-endoperoxide synthase 2 Homo sapiens 189-194 10898226-2 2000 Recently, we reported that lysophosphatidylcholine (L-PC), the PLA2 hydrolysis product of phosphatidylcholine (PC), stimulates bacterial translocation (BT) in an enterocyte cell-culture model. Phosphatidylcholines 54-56 phospholipase A2 group IIA Homo sapiens 63-67 10898226-8 2000 Thin-layer chromatography (TLC) was utilized to verify PLA2 hydrolysis of PC to L-PC. Phosphatidylcholines 74-76 phospholipase A2 group IIA Homo sapiens 55-59 10898226-13 2000 PLA2 mediates hydrolysis of PC to L-PC when both are applied to the apical surface of cultured enterocyte monolayers, resulting in increased BT and increased TEER with no damage to monolayer integrity. Phosphatidylcholines 28-30 phospholipase A2 group IIA Homo sapiens 0-4 10591668-1 1999 We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions. Phosphatidylcholines 194-214 phospholipase A2 group VII Homo sapiens 29-70 10600179-6 1999 Finally, resveratrol inhibited PKCalpha when activated by phosphatidylcholine/phosphatidylserine vesicles with an IC(50) of 30 microM, whereas when the enzyme was activated by Triton X-100 micelles the IC(50) was 300 microM. Phosphatidylcholines 58-77 protein kinase C alpha Homo sapiens 31-39 10591668-1 1999 We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions. Phosphatidylcholines 194-214 phospholipase A2 group VII Homo sapiens 72-81 10591668-8 1999 It is concluded that (1) macrophages in both human and rabbit atherosclerotic lesions express Lp-PLA(2), which could cleave any oxidatively modified phosphatidylcholine present in the lesion area, and (2) modulation of Lp-PLA(2) activity could lead to antiatherogenic effects in the vessel wall. Phosphatidylcholines 149-168 phospholipase A2 group VII Homo sapiens 94-103 10638197-2 1999 MTP catalyzes the transfer of triglyceride, cholesteryl ester and phosphatidylcholine between membranes and lipoproteins. Phosphatidylcholines 66-85 microsomal triglyceride transfer protein Rattus norvegicus 0-3 10746170-4 1999 The addition of P-9 to phosphatidylcholine (PC) liposomes containing cholesterol (Chol) gave rise to an increase of absorption intensity at around pH 4.0. Phosphatidylcholines 23-42 exosome component 8 Homo sapiens 16-19 10746170-4 1999 The addition of P-9 to phosphatidylcholine (PC) liposomes containing cholesterol (Chol) gave rise to an increase of absorption intensity at around pH 4.0. Phosphatidylcholines 44-46 exosome component 8 Homo sapiens 16-19 10746170-5 1999 The increase of turbidity by P-9 addition did not decrease with increasing pH, indicating P-9-mediated fusion of PC liposomes. Phosphatidylcholines 113-115 exosome component 8 Homo sapiens 90-93 10746170-7 1999 The membrane fluidity close to the polar head groups of the fatty acyl chains of PC affected markedly the extent of P-9-mediated liposome fusion. Phosphatidylcholines 81-83 exosome component 8 Homo sapiens 116-119 10561698-1 1999 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines 67-86 cut like homeobox 1 Homo sapiens 0-3 10561698-1 1999 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines 88-94 cut like homeobox 1 Homo sapiens 0-3 10561698-3 1999 Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid (AA), after ischemia/reperfusion. Phosphatidylcholines 48-54 cut like homeobox 1 Homo sapiens 25-28 10561698-10 1999 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines 34-40 cut like homeobox 1 Homo sapiens 0-3 10561698-10 1999 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines 110-116 cut like homeobox 1 Homo sapiens 0-3 10562546-0 1999 Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling. Phosphatidylcholines 105-124 phospholipase D1 Homo sapiens 33-49 10567392-6 1999 The mature sPLA(2)-X induced the release of arachidonic acid from phosphatidylcholine more efficiently than other human sPLA(2) groups (IB, IIA, IID, and V) and elicited a prompt and marked release of arachidonic acid from human monocytic THP-1 cells compared with sPLA(2)-IB and -IIA with concomitant production of prostaglandin E(2). Phosphatidylcholines 66-85 phospholipase A2 group X Homo sapiens 11-20 10562546-0 1999 Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 151-154 10542105-3 1999 ApoC-II(19-39) forms approximately 60% alpha-helix upon binding to model egg yolk phosphatidylcholine small unilamellar vesicles. Phosphatidylcholines 82-101 apolipoprotein C2 Homo sapiens 0-7 10533050-5 1999 Analysis of the microsomal membrane fraction P(3) revealed that, in apoE-deficient mice, these membranes contain significantly lower levels of phosphatidylcholine (PC) than those of control mice. Phosphatidylcholines 143-162 apolipoprotein E Mus musculus 68-72 10533050-5 1999 Analysis of the microsomal membrane fraction P(3) revealed that, in apoE-deficient mice, these membranes contain significantly lower levels of phosphatidylcholine (PC) than those of control mice. Phosphatidylcholines 164-166 apolipoprotein E Mus musculus 68-72 10707279-1 1999 Using fluorescent probes DSM and DSP-12, the effect of ribonuclease and lysozyme on the structural state of liposomes composed of phosphatidylcholine and diphosphatidylglycerol was studied. Phosphatidylcholines 130-149 lysozyme Homo sapiens 72-80 10537140-0 1999 Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 320-339 interleukin 1 complex Mus musculus 71-75 10537140-0 1999 Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 320-339 interleukin 6 Mus musculus 85-89 10783747-5 1999 Phosphatidylcholine, phosphatidylethanolamine and cardiolipin were decreased significantly by 40%, 49% and 60% respectively in CCl4 treated rats. Phosphatidylcholines 0-19 C-C motif chemokine ligand 4 Rattus norvegicus 127-131 10548476-1 1999 Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups. Phosphatidylcholines 105-124 phosphatidylethanolamine N-methyltransferase Bos taurus 0-44 10548476-1 1999 Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups. Phosphatidylcholines 105-124 phosphatidylethanolamine N-methyltransferase Bos taurus 46-56 10654293-8 1999 Phosphorus NMR spectroscopy shows that phosphatidylcholine, phosphatidylinositol, sphingomyelin, and phosphatidylserine increase steadily from F15 to P21. Phosphatidylcholines 39-58 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 150-153 10552998-7 1999 As in vitro studies revealed that Mdr2 Pgp is not able to translocate these lipid analogues, we hypothesized that Mdr2 -/- mice had a reduced PC content of the exoplasmic canalicular membrane leaflet so that extraction of the short-chain lipid probes from this membrane by canalicular bile salts was impaired. Phosphatidylcholines 142-144 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 114-118 10552998-11 1999 These data confirm that the efficiency of NBD-SM extraction depends on the lipid composition and suggest that the canalicular membrane outer leaflet of Mdr2 -/- mice has a reduced PC content. Phosphatidylcholines 180-182 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 152-156 10542325-1 1999 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 109-129 phosphatidylcholine transfer protein Homo sapiens 0-36 10542325-1 1999 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. Phosphatidylcholines 109-129 phosphatidylcholine transfer protein Homo sapiens 38-43 10497177-4 1999 FXa generation at a rotating disc coated with TF embedded in a membrane composed of pure phosphatidylcholine (TF.PC) or 25% phosphatidylserine and 75% phosphatidylcholine (TF.PSPC) was measured in the presence of preformed complexes of FXa.TFPI(FL) or FXa.TFPI(1-161) (TFPI lacking the third Kunitz domain and C terminus). Phosphatidylcholines 89-108 coagulation factor X Homo sapiens 0-3 10529238-0 1999 Change in the positional specificity of lipoxygenase 1 due to insertion of fatty acids into phosphatidylcholine deoxycholate mixed micelles. Phosphatidylcholines 92-111 seed linoleate 13S-lipoxygenase-1 Glycine max 40-54 10529238-3 1999 The fatty acids inserted into phosphatidylcholine micelles were better substrates for soybean lipoxygenase 1 (LOX1) with two distinct pH optima at 7.0 and 10.0. Phosphatidylcholines 30-49 seed linoleate 13S-lipoxygenase-1 Glycine max 94-108 10529238-3 1999 The fatty acids inserted into phosphatidylcholine micelles were better substrates for soybean lipoxygenase 1 (LOX1) with two distinct pH optima at 7.0 and 10.0. Phosphatidylcholines 30-49 seed linoleate 13S-lipoxygenase-1 Glycine max 110-114 10604109-4 1999 The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 11 Homo sapiens 62-76 10604109-4 1999 The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2. Phosphatidylcholines 140-159 phosphoglycolate phosphatase Homo sapiens 77-80 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10529371-4 1999 Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC. Phosphatidylcholines 257-259 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 10529371-4 1999 Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC. Phosphatidylcholines 257-259 formyl peptide receptor 1 Homo sapiens 117-121 10497200-10 1999 These results show that quite minor constituents of the LDL phosphatidylcholine pool are the exclusive precursors for PAF-like bioactivity in oxidized LDL. Phosphatidylcholines 60-79 PCNA clamp associated factor Homo sapiens 118-121 10497177-4 1999 FXa generation at a rotating disc coated with TF embedded in a membrane composed of pure phosphatidylcholine (TF.PC) or 25% phosphatidylserine and 75% phosphatidylcholine (TF.PSPC) was measured in the presence of preformed complexes of FXa.TFPI(FL) or FXa.TFPI(1-161) (TFPI lacking the third Kunitz domain and C terminus). Phosphatidylcholines 151-170 coagulation factor X Homo sapiens 0-3 10500206-1 1999 Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function. Phosphatidylcholines 77-96 phosphatidylcholine transfer protein Mus musculus 0-36 10473578-0 1999 Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) --> G(1) transition. Phosphatidylcholines 123-142 solute carrier family 25 member 1 Homo sapiens 13-52 10473578-2 1999 We examined the rates of phosphatidylcholine (PC) synthesis and the activity, membrane affinity, and intracellular localization of the rate-limiting enzyme in the synthesis of PC, CTP:phosphocholine cytidylyltransferase (CT) during this transition. Phosphatidylcholines 176-178 solute carrier family 25 member 1 Homo sapiens 180-219 10504221-4 1999 Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide. Phosphatidylcholines 38-57 surfactant protein C Homo sapiens 59-61 10504221-4 1999 Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide. Phosphatidylcholines 38-57 myristoylated alanine rich protein kinase C substrate Homo sapiens 120-126 10500206-1 1999 Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function. Phosphatidylcholines 77-96 phosphatidylcholine transfer protein Mus musculus 38-43 10412048-1 1999 We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 166-185 fibroblast growth factor 2 Mus musculus 26-56 10462379-1 1999 The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. Phosphatidylcholines 43-45 phosphatidylethanolamine N-methyltransferase Mus musculus 190-194 10462379-4 1999 The PC concentration in gallbladder bile of mice that synthesize PC mainly via the CDP-choline pathway was comparable with control mice that synthesize PC via both pathways, whereas it was reduced by approximately 40% in mice that synthesize PC via the PEMT pathway. Phosphatidylcholines 4-6 phosphatidylethanolamine N-methyltransferase Mus musculus 253-257 10465754-1 1999 The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques. Phosphatidylcholines 91-110 proopiomelanocortin Homo sapiens 55-69 10462379-1 1999 The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. Phosphatidylcholines 22-41 phosphatidylethanolamine N-methyltransferase Mus musculus 190-194 10412048-1 1999 We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 166-185 fibroblast growth factor 2 Mus musculus 58-62 10412048-1 1999 We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 166-185 interleukin 6 Mus musculus 225-238 10412048-1 1999 We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 166-185 interleukin 6 Mus musculus 240-244 10412048-1 1999 We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 166-185 fibroblast growth factor 2 Mus musculus 259-263 10507691-1 1999 We describe the inhibitory effect of A beta (25-35) fragment of amyloid-beta peptide and bradykinin (BK) on phosphatidylcholine (PtdCho) metabolism in immortalized rat brain GP8.39 endothelial cells (EC). Phosphatidylcholines 108-127 amyloid beta precursor protein Rattus norvegicus 37-43 10484608-6 1999 The addition of phosphatidylcholine liposomes substantially increased cholesterol efflux from apoE-expressing and non-expressing J774 cells. Phosphatidylcholines 16-35 apolipoprotein E Mus musculus 94-98 10484608-8 1999 On the other hand, even in the presence of phosphatidylcholine liposomes, cholesterol efflux rates remained significantly higher from apoE-expressing macrophages than non-expressing cells. Phosphatidylcholines 43-62 apolipoprotein E Homo sapiens 134-138 10461922-4 1999 Under optimal conditions, the iPLA2 revealed the following substrate preference toward the fatty acid chain in the sn-2 position of phosphatidylcholine: linoleoyl > palmitoyl > oleoyl > arachidonoyl. Phosphatidylcholines 132-151 phospholipase A2 group VI Rattus norvegicus 30-35 10507691-1 1999 We describe the inhibitory effect of A beta (25-35) fragment of amyloid-beta peptide and bradykinin (BK) on phosphatidylcholine (PtdCho) metabolism in immortalized rat brain GP8.39 endothelial cells (EC). Phosphatidylcholines 129-135 amyloid beta precursor protein Rattus norvegicus 37-43 10507691-3 1999 The BK (10 microM) stimulation of cells brought about an increase in conjugated dienes and LDH release only after 4 h. Following 24 h treatment with 50 microM A beta peptide, the [Me-3H]choline incorporation into PtdCho strongly decreased while the [3H]choline release increased, indicating PtdCho hydrolysis. Phosphatidylcholines 213-219 amyloid beta precursor protein Rattus norvegicus 159-165 10448079-0 1999 Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein. Phosphatidylcholines 13-32 ATP binding cassette subfamily B member 4 Homo sapiens 36-40 10446285-1 1999 Resonance energy transfer between a series of lipid-bound fluorescent probes as donors and the heme group of cytochrome c as acceptor has been used to obtain structural information on the protein complexes with model membranes, composed of phosphatidylcholine and cardiolipin. Phosphatidylcholines 240-259 cytochrome c, somatic Homo sapiens 109-121 10446298-1 1999 We have investigated the wasp venom peptides mastoparan X and polistes mastoparan regarding their apparent potential to induce pore-like defects in phosphatidylcholine unilamellar vesicles. Phosphatidylcholines 148-167 WASP actin nucleation promoting factor Homo sapiens 25-29 10448079-0 1999 Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein. Phosphatidylcholines 13-32 ATP binding cassette subfamily B member 1 Homo sapiens 89-93 10448079-2 1999 We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics. Phosphatidylcholines 41-60 ATP binding cassette subfamily B member 1 Homo sapiens 28-32 10448079-2 1999 We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics. Phosphatidylcholines 41-60 phosphoglycolate phosphatase Homo sapiens 33-37 10448079-2 1999 We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics. Phosphatidylcholines 41-60 ATP binding cassette subfamily B member 4 Homo sapiens 74-78 10448079-6 1999 Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low. Phosphatidylcholines 92-111 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 10486736-4 1999 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was also utilized to confirm the phosphatidylcholine, a substrate of sPLA2. Phosphatidylcholines 110-129 phospholipase A2 group X Homo sapiens 146-151 10448079-6 1999 Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low. Phosphatidylcholines 92-111 phosphoglycolate phosphatase Homo sapiens 51-55 10448079-6 1999 Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low. Phosphatidylcholines 92-111 ATP binding cassette subfamily B member 1 Homo sapiens 133-137 10448079-6 1999 Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low. Phosphatidylcholines 92-111 phosphoglycolate phosphatase Homo sapiens 138-142 10448079-7 1999 The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype. Phosphatidylcholines 30-49 ATP binding cassette subfamily B member 1 Homo sapiens 17-21 10448079-7 1999 The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype. Phosphatidylcholines 30-49 phosphoglycolate phosphatase Homo sapiens 22-26 10448079-7 1999 The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype. Phosphatidylcholines 30-49 phosphoglycolate phosphatase Homo sapiens 100-104 10432300-1 1999 Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn). Phosphatidylcholines 131-150 phosphatidylserine synthase 1 Homo sapiens 92-115 10448079-7 1999 The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype. Phosphatidylcholines 30-49 ATP binding cassette subfamily B member 1 Homo sapiens 140-144 10469152-3 1999 Phosphatidylcholine liposomes were treated by octylglucoside to insert a glycosyl-PtdIns-protein, alkaline phosphatase (ALP), some cholesterol, and a GlySph, the lactocerebroside. Phosphatidylcholines 0-19 alkaline phosphatase, placental Homo sapiens 98-118 10441140-0 1999 Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles. Phosphatidylcholines 27-47 phospholipase A2, major isoenzyme Sus scrofa 51-67 10441140-1 1999 Hydrolysis of monodisperse short chain phosphatidylcholines, far below their critical micelle concentration, by phospholipase A2 (PLA2) and other interfacial enzymes is characterized. Phosphatidylcholines 39-59 phospholipase A2, major isoenzyme Sus scrofa 112-128 10441140-1 1999 Hydrolysis of monodisperse short chain phosphatidylcholines, far below their critical micelle concentration, by phospholipase A2 (PLA2) and other interfacial enzymes is characterized. Phosphatidylcholines 39-59 phospholipase A2, major isoenzyme Sus scrofa 130-134 10469152-3 1999 Phosphatidylcholine liposomes were treated by octylglucoside to insert a glycosyl-PtdIns-protein, alkaline phosphatase (ALP), some cholesterol, and a GlySph, the lactocerebroside. Phosphatidylcholines 0-19 alkaline phosphatase, placental Homo sapiens 120-123 10419523-2 1999 The rate of PLCdelta1 hydrolysis of phosphatidylinositol 4,5-bisphosphate was stimulated 20-fold by phosphatidylserine (PS), 4-fold by phosphatidic acid (PA), and not at all by phosphatidylethanolamine or phosphatidylcholine (PC). Phosphatidylcholines 205-224 phospholipase C delta 1 Homo sapiens 12-21 10517269-1 1999 In cholinergic neurons choline is directed to three main pathways; (1) conversion to phosphorylcholine (PCh) and cytidine diphosphate choline (CDP-choline) for the synthesis of phosphatidylcholine, (2) acylation to the neurotransmitter acetylcholine and (3) oxidation to betaine for the formation of methionine. Phosphatidylcholines 177-196 cut like homeobox 1 Homo sapiens 143-146 10413522-1 1999 Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption. Phosphatidylcholines 247-266 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 223-230 10425393-1 1999 While yeast contain multiple phospholipase D activities, only one, encoded by SPO14, appears to be a member of the phosphatidylcholine-specific phospholipase D gene family. Phosphatidylcholines 115-134 phospholipase D Saccharomyces cerevisiae S288C 78-83 10425393-1 1999 While yeast contain multiple phospholipase D activities, only one, encoded by SPO14, appears to be a member of the phosphatidylcholine-specific phospholipase D gene family. Phosphatidylcholines 115-134 phospholipase D Saccharomyces cerevisiae S288C 144-159 10415339-1 1999 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that promotes intermembrane transfer of phosphatidylcholines but no other phospholipids. Phosphatidylcholines 123-143 phosphatidylcholine transfer protein Rattus norvegicus 0-36 10415339-1 1999 Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that promotes intermembrane transfer of phosphatidylcholines but no other phospholipids. Phosphatidylcholines 123-143 phosphatidylcholine transfer protein Rattus norvegicus 38-43 10425391-2 1999 Virtually every cell uses phosphatidylcholine as substrate to produce phosphatidic acid in a controlled reaction catalyzed by specific PLD isoforms. Phosphatidylcholines 26-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 10409698-6 1999 Purified NAP-22 bound to the liposomes that were made from phosphatidylcholine and cholesterol. Phosphatidylcholines 59-78 brain abundant membrane attached signal protein 1 Homo sapiens 9-15 10413522-1 1999 Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption. Phosphatidylcholines 247-266 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 235-242 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 44-48 10395967-0 1999 Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. Phosphatidylcholines 14-33 phospholipase A2 Cricetulus griseus 69-85 10395967-9 1999 Glycerophosphocholine is the PtdCho catabolite that accumulates in the transfected cells, which suggests that PtdCho turnover is mediated by a phospholipase A2 (PLA2). Phosphatidylcholines 29-35 phospholipase A2 Cricetulus griseus 143-159 10395967-9 1999 Glycerophosphocholine is the PtdCho catabolite that accumulates in the transfected cells, which suggests that PtdCho turnover is mediated by a phospholipase A2 (PLA2). Phosphatidylcholines 29-35 phospholipase A2 Cricetulus griseus 161-165 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 phospholipase A2 group VII Homo sapiens 40-82 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 phospholipase A2 group VII Homo sapiens 84-90 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 lecithin-cholesterol acyltransferase Homo sapiens 96-132 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 lecithin-cholesterol acyltransferase Homo sapiens 134-138 10395737-5 1999 For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively. Phosphatidylcholines 64-83 glutathione S-transferase alpha 1 Homo sapiens 51-59 10395737-5 1999 For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively. Phosphatidylcholines 64-83 glutathione S-transferase alpha 2 Homo sapiens 241-249 10383445-1 1999 We have developed a simple fluorescent assay for detection of phospholipase A2 (PLA2) activity in zebrafish embryos that utilizes a fluorescent phosphatidylcholine substrate. Phosphatidylcholines 144-163 phospholipase A2, group IB (pancreas) Danio rerio 62-78 10383445-1 1999 We have developed a simple fluorescent assay for detection of phospholipase A2 (PLA2) activity in zebrafish embryos that utilizes a fluorescent phosphatidylcholine substrate. Phosphatidylcholines 144-163 phospholipase A2, group IB (pancreas) Danio rerio 80-84 10383445-8 1999 By using a quenched BODIPY-labeled phosphatidylcholine that fluoresces only upon cleavage by PLA2, lipase activity was visualized in the cells of living embryos where it localized to perinuclear membranes. Phosphatidylcholines 35-54 phospholipase A2, group IB (pancreas) Danio rerio 93-97 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 50-54 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 50-54 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 50-54 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 10336610-2 1999 PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns). Phosphatidylcholines 48-67 phospholipase C delta 3 Homo sapiens 0-10 10411684-7 1999 "Flip flop" was gauged by preferential decrements in phosphatidylserine (PS) versus phosphatidylcholine (PC; PS/PC ratios) in response to extracellular (Naja) PLA2 exposure. Phosphatidylcholines 84-103 phospholipase A2, group IB, pancreas Mus musculus 159-163 10397762-4 1999 We now report that, in addition to a dramatic accumulation of phosphatidylinositol-4-phosphate, sac1 mutants also exhibit a specific acceleration of phosphatidylcholine biosynthesis via the CDP-choline pathway. Phosphatidylcholines 149-168 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 96-100 10397762-5 1999 This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase. Phosphatidylcholines 5-24 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 114-120 10397762-5 1999 This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase. Phosphatidylcholines 5-24 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 124-128 10397762-5 1999 This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase. Phosphatidylcholines 5-24 phospholipase D Saccharomyces cerevisiae S288C 143-158 10393333-0 1999 Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase. Phosphatidylcholines 23-43 lecithin-cholesterol acyltransferase Homo sapiens 90-126 10393333-1 1999 The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated. Phosphatidylcholines 102-121 lecithin-cholesterol acyltransferase Homo sapiens 28-64 10393333-1 1999 The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated. Phosphatidylcholines 102-121 lecithin-cholesterol acyltransferase Homo sapiens 66-70 10393333-1 1999 The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated. Phosphatidylcholines 123-125 lecithin-cholesterol acyltransferase Homo sapiens 28-64 10393333-1 1999 The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated. Phosphatidylcholines 123-125 lecithin-cholesterol acyltransferase Homo sapiens 66-70 10393333-4 1999 In the present study, we found that LCAT produces various metabolites from oxidized PC and that oxidized PC molecules in LDL particles serve as substrates. Phosphatidylcholines 84-86 lecithin-cholesterol acyltransferase Homo sapiens 36-40 10393333-13 1999 These results suggest that LCAT is capable of metabolizing a variety of oxidized products of PC and preventing the accumulation of oxidized PC in circulating LDL particles. Phosphatidylcholines 93-95 lecithin-cholesterol acyltransferase Homo sapiens 27-31 10393333-13 1999 These results suggest that LCAT is capable of metabolizing a variety of oxidized products of PC and preventing the accumulation of oxidized PC in circulating LDL particles. Phosphatidylcholines 140-142 lecithin-cholesterol acyltransferase Homo sapiens 27-31 10336610-2 1999 PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns). Phosphatidylcholines 69-75 phospholipase C delta 3 Homo sapiens 0-10 10336610-2 1999 PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns). Phosphatidylcholines 80-86 phospholipase C delta 3 Homo sapiens 0-10 10341225-8 1999 ATP also stimulated a rapid increase in choline, and inhibition of phosphatidylcholine hydrolysis blocked ATP-evoked ERK activation. Phosphatidylcholines 67-86 Eph receptor B1 Rattus norvegicus 117-120 10411659-10 1999 The rate of phosphatidylcholine synthesis was barely affected, but mass was moderately reduced by a 48-h treatment of cells with IL-1beta. Phosphatidylcholines 12-31 interleukin 1 beta Homo sapiens 129-137 10411659-11 1999 Finally, the efflux of cell [3H]cholesterol, [3H]sphingomyelin, and [3H]phosphatidylcholine to lipid-free apolipoprotein A-I was markedly increased from cells treated with IL-1beta for 24 and 48 h. We conclude that long-term exposure of cells to IL-1beta had marked effects on the cellular homeostasis of cholesterol and choline-containing phospholipids. Phosphatidylcholines 72-91 interleukin 1 beta Homo sapiens 172-180 10341225-9 1999 These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors. Phosphatidylcholines 231-250 Eph receptor B1 Rattus norvegicus 166-169 10341225-9 1999 These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors. Phosphatidylcholines 231-250 Eph receptor B1 Rattus norvegicus 166-169 10341225-9 1999 These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors. Phosphatidylcholines 231-250 Eph receptor B1 Rattus norvegicus 166-169 10207008-2 1999 We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem. Phosphatidylcholines 65-84 phospholipase A2 group IIA Homo sapiens 40-44 10329685-12 1999 Whereas the EKI1 gene product was primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, the CKI1 gene product was primarily responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Phosphatidylcholines 181-200 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 133-137 10224048-7 1999 Together, our data provide a long sought mechanism as to how defects in Sac1p overcome certain actin mutants and bypass the requirement for yeast phosphatidylinositol/phosphatidylcholine transfer protein, Sec14p. Phosphatidylcholines 167-186 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 72-77 10224048-7 1999 Together, our data provide a long sought mechanism as to how defects in Sac1p overcome certain actin mutants and bypass the requirement for yeast phosphatidylinositol/phosphatidylcholine transfer protein, Sec14p. Phosphatidylcholines 167-186 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 205-211 10230818-9 1999 The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters. Phosphatidylcholines 72-91 phospholipase A2, group IB, pancreas Mus musculus 57-61 10230818-9 1999 The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters. Phosphatidylcholines 51-53 phospholipase A2, group IB, pancreas Mus musculus 57-61 10207000-5 1999 Dimeric Ymt was shown to have PLD-like activity as demonstrated by the hydrolysis of phosphatidylcholine. Phosphatidylcholines 85-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 10347126-0 1999 Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin-treated rat. Phosphatidylcholines 72-91 ATP binding cassette subfamily B member 4 Rattus norvegicus 15-19 10320809-8 1999 In the sn-1 to -2 transfer, the sn-1 acyl residue of 1-acyl-sn-glycero-3-phosphocholine was transferred to not only the sn-2 positions of 1-acyl-sn-glycero-3-phosphocholine, but also 1-acyl-sn-glycero-3-phosphoethanolamine, producing phosphatidylcholine and phosphatidylethanolamine, respectively. Phosphatidylcholines 234-253 heterogeneous nuclear ribonucleoprotein U Rattus norvegicus 7-17 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Phosphatidylcholines 48-67 phospholipase A2, group VI Mus musculus 24-29 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Phosphatidylcholines 48-67 phospholipase A2, group VI Mus musculus 175-180 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Phosphatidylcholines 70-72 phospholipase A2, group VI Mus musculus 24-29 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Phosphatidylcholines 70-72 phospholipase A2, group VI Mus musculus 175-180 10381281-1 1999 Phosphatidylcholines (1-O-alcoxy-2-amino-2-desoxy-phosphocholines and 1-pyrene-labeled analogs) were synthesized and used to examine interactions with recombinant human PAF-acetylhydrolase (PAF-AH), an enzyme purified from plasma, and with macrophage-like U937 cells. Phosphatidylcholines 0-20 phospholipase A2 group VII Homo sapiens 169-188 10198439-5 1999 Specifically, the response to nitrogen limitation is dependent upon the presence of a functional OPI1 gene product, it requires ongoing phosphatidylcholine biosynthesis and it is mediated by the repeated element, UASINO, found in the promoter of INO1 and other co-regulated genes of phospholipid biosynthesis. Phosphatidylcholines 136-155 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 97-101 10198439-5 1999 Specifically, the response to nitrogen limitation is dependent upon the presence of a functional OPI1 gene product, it requires ongoing phosphatidylcholine biosynthesis and it is mediated by the repeated element, UASINO, found in the promoter of INO1 and other co-regulated genes of phospholipid biosynthesis. Phosphatidylcholines 136-155 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 246-250 10207008-2 1999 We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem. Phosphatidylcholines 65-84 phospholipase A2 group IIA Homo sapiens 48-52 10207008-2 1999 We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem. Phosphatidylcholines 86-88 phospholipase A2 group IIA Homo sapiens 40-44 10207008-2 1999 We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem. Phosphatidylcholines 86-88 phospholipase A2 group IIA Homo sapiens 48-52 10216289-1 1999 CTP:phosphocholine cytidylyltransferase plays a key role in regulating the rate of phosphatidylcholine biosynthesis. Phosphatidylcholines 83-102 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 10086319-3 1999 The administration of tiadenol, DEHP, or clofibric acid slightly, but significantly, increased, in common, the activity of CTP:phosphocholine cytidylyltransferase, a key enzyme for the synthesis de novo of PtdCho, and suppressed the activity of PtdEtn N-methyltransferase. Phosphatidylcholines 206-212 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 123-162 10092620-11 1999 Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC. Phosphatidylcholines 23-29 glycophorin E (MNS blood group) Homo sapiens 124-127 10196168-7 1999 Similarly, treatment of acetyl LDL with phospholipase A2 converted more than 90% of the initial content of phosphatidylcholine (PC) to lyso-PC, but the phospholipase A2-treated acetyl LDL was nearly 10-fold less potent than oxidized LDL at stimulating growth. Phosphatidylcholines 107-126 phospholipase A2 group IB Homo sapiens 40-56 10191259-1 1999 Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol. Phosphatidylcholines 71-90 cut like homeobox 1 Homo sapiens 163-166 10191259-1 1999 Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol. Phosphatidylcholines 92-98 cut like homeobox 1 Homo sapiens 163-166 10196168-7 1999 Similarly, treatment of acetyl LDL with phospholipase A2 converted more than 90% of the initial content of phosphatidylcholine (PC) to lyso-PC, but the phospholipase A2-treated acetyl LDL was nearly 10-fold less potent than oxidized LDL at stimulating growth. Phosphatidylcholines 128-130 phospholipase A2 group IB Homo sapiens 40-56 10092620-11 1999 Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC. Phosphatidylcholines 78-84 glycophorin E (MNS blood group) Homo sapiens 124-127 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 93-112 lipoprotein(a) Homo sapiens 29-43 10198353-6 1999 Cessation of aerosolized GM-CSF for 5 wk resulted in increased saturated phosphatidylcholine pool sizes that returned to pretreatment levels. Phosphatidylcholines 73-92 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 25-31 10096907-1 1999 We determined the orientation of a biotinylated version of the pore-forming peptide GALA (WEAALAEALAEALAEHLAEALAEALEALAA) at pH 5.0 in large unilamellar phosphatidylcholine vesicles, using the enhancement of BODIPY-avidin fluorescence subsequent to its irreversible binding to a biotin moiety. Phosphatidylcholines 153-172 galactosidase alpha Homo sapiens 84-88 10194607-6 1999 Although both types of tested liposomes induced similar cellular changes, only liposomes made of pure egg yolk phosphatidylcholine induced a transient increase in serum TNF-alpha levels. Phosphatidylcholines 111-130 tumor necrosis factor Mus musculus 169-178 10319417-3 1999 When linoleic acids micelles or phosphatidylcholine liposomes were incubated with Cu,Zn-SOD and H2O2, lipid peroxidation was gradually increased in a time-dependent manner. Phosphatidylcholines 32-51 superoxide dismutase 1 Homo sapiens 88-91 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 93-112 lipoprotein(a) Homo sapiens 45-49 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 93-112 phospholipase A2 group IB Homo sapiens 55-71 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 93-112 phospholipase A2 group IB Homo sapiens 73-77 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 114-116 lipoprotein(a) Homo sapiens 29-43 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 114-116 lipoprotein(a) Homo sapiens 45-49 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 114-116 phospholipase A2 group IB Homo sapiens 55-71 10191282-1 1999 In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. Phosphatidylcholines 114-116 phospholipase A2 group IB Homo sapiens 73-77 10073990-10 1999 Moreover, this phenomenon appears to result not only from the significantly elevated PC to free cholesterol ratio (1.54:1) in dense LDL particles (1.15:1 to 1.25:1 for other LDL subclasses) but also from their unique structural features, including a distinct apoB100 conformation, which may facilitate covalent bond formation between oxidized CE and apoB100. Phosphatidylcholines 85-87 apolipoprotein B Homo sapiens 259-266 10322420-4 1999 These processes involve the regulation of the CDP-choline and phosphatidylethanolamine-methylation pathways of phosphatidylcholine synthesis, CTP synthetase, phospholipase D and the phospholipid-transfer protein Sec14p. Phosphatidylcholines 111-130 cut like homeobox 1 Homo sapiens 46-49 10101272-3 1999 In addition, we have found a PPAR-independent mechanism in which fibrates, known peroxisome proliferators, decrease hepatic secretion of very low density lipoproteins (VLDL) through inhibition of phosphatidylcholine synthesis via methylation of phosphatidylethanolamine (PE) (T. Nishimaki-Mogami et al., Biochim. Phosphatidylcholines 196-215 peroxisome proliferator activated receptor alpha Rattus norvegicus 29-33 10037681-1 1999 Mammalian phosphatidylcholine-specific phospholipase D1 (PLD1) is a signal transduction-activated enzyme thought to function in multiple cell biological settings including the regulation of membrane vesicular trafficking. Phosphatidylcholines 10-29 phospholipase D1 Homo sapiens 39-55 10037681-1 1999 Mammalian phosphatidylcholine-specific phospholipase D1 (PLD1) is a signal transduction-activated enzyme thought to function in multiple cell biological settings including the regulation of membrane vesicular trafficking. Phosphatidylcholines 10-29 phospholipase D1 Homo sapiens 57-61 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 protein kinase C alpha Homo sapiens 38-41 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 protein kinase C alpha Homo sapiens 222-231 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 173-179 protein kinase C alpha Homo sapiens 38-41 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 173-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 173-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 10353318-4 1999 The sialidase-treated LPL also showed similar hydrolyzing activity for triolein emulsified with Triton X-100, phosphatidylcholine and phosphatidylethanolamine, whereas it showed significantly increased hydrolyzing activity for triolein emulsified with phosphatidylserine and cardiolipin (152% and 183%, compared with untreated LPL, respectively). Phosphatidylcholines 110-129 lipoprotein lipase Homo sapiens 22-25 10101264-1 1999 CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading. Phosphatidylcholines 98-117 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 10101264-1 1999 CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading. Phosphatidylcholines 119-121 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 10082883-1 1999 Cytidine and choline, present in cytidine 5"-diphosphate choline (CDP-choline), are major precursors of the phosphatidylcholine found in cell membranes and important regulatory elements in phosphatide biosynthesis. Phosphatidylcholines 108-127 cut-like homeobox 1 Rattus norvegicus 66-69 10082883-2 1999 Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine. Phosphatidylcholines 215-234 cut-like homeobox 1 Rattus norvegicus 18-21 10082883-2 1999 Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine. Phosphatidylcholines 215-234 cut-like homeobox 1 Rattus norvegicus 136-139 10218592-3 1999 The reaction kinetics of lecithin-cholesterol acyltransferase with reconstitued high density lipoproteins were studied in the presence of 0.6 and 1.2 microM hydroperoxides of phosphatidylcholine. Phosphatidylcholines 175-194 lecithin-cholesterol acyltransferase Homo sapiens 25-61 10218592-6 1999 Nevertheless, hydroperoxides of phosphatidylcholine altered the reactivity of lecithin-cholesterol acyltransferase for reconstitued high density lipoproteins suggesting either an alteration of the binding of lecithin-cholesterol acyltransferase to the reconstitued high density lipoproteins or a competitive inhibition mechanism. Phosphatidylcholines 32-51 lecithin-cholesterol acyltransferase Homo sapiens 78-114 10218592-6 1999 Nevertheless, hydroperoxides of phosphatidylcholine altered the reactivity of lecithin-cholesterol acyltransferase for reconstitued high density lipoproteins suggesting either an alteration of the binding of lecithin-cholesterol acyltransferase to the reconstitued high density lipoproteins or a competitive inhibition mechanism. Phosphatidylcholines 32-51 lecithin-cholesterol acyltransferase Homo sapiens 208-244 10037768-2 1999 Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles. Phosphatidylcholines 77-96 protein C receptor Homo sapiens 21-25 10037768-2 1999 Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles. Phosphatidylcholines 77-96 thrombomodulin Homo sapiens 30-44 10037768-2 1999 Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles. Phosphatidylcholines 77-96 thrombomodulin Homo sapiens 46-48 10049506-7 1999 Interestingly, although PKC-alpha also mediates the stimulatory effect of PMA on the synthesis of PtdCho by a phosphorylation mechanism, overexpression of holo PKC-epsilon or its regulatory domain fragments did not affect PMA-induced PtdCho synthesis. Phosphatidylcholines 98-104 protein kinase C alpha Homo sapiens 24-33 10073990-10 1999 Moreover, this phenomenon appears to result not only from the significantly elevated PC to free cholesterol ratio (1.54:1) in dense LDL particles (1.15:1 to 1.25:1 for other LDL subclasses) but also from their unique structural features, including a distinct apoB100 conformation, which may facilitate covalent bond formation between oxidized CE and apoB100. Phosphatidylcholines 85-87 apolipoprotein B Homo sapiens 350-357 10194059-2 1999 These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells. Phosphatidylcholines 124-143 Rac family small GTPase 1 Homo sapiens 262-266 10217630-3 1999 The reciprocal nature of the decrease in phosphatidylcholine concentration, compared with the increase in the concentration of 1-lysophosphatidylcholine and 2-lysophosphatidylcholine, suggested a substrate/product relationship consistent with the activities of phospholipase A1 and phospholipase A2, respectively. Phosphatidylcholines 41-60 lipase H Homo sapiens 261-277 10217630-3 1999 The reciprocal nature of the decrease in phosphatidylcholine concentration, compared with the increase in the concentration of 1-lysophosphatidylcholine and 2-lysophosphatidylcholine, suggested a substrate/product relationship consistent with the activities of phospholipase A1 and phospholipase A2, respectively. Phosphatidylcholines 41-60 phospholipase A2 group IB Homo sapiens 282-298 10194059-2 1999 These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells. Phosphatidylcholines 124-143 H3 histone pseudogene 16 Homo sapiens 268-271 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 80-99 heparan sulfate proteoglycan 2 Homo sapiens 134-137 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 74-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 74-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10072552-0 1999 A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages. Phosphatidylcholines 2-21 cyclin dependent kinase 20 Homo sapiens 71-74 10079112-3 1999 Analysis of plasma of F2 homozygous PLTP-/- mice showed complete loss of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, sphingomyelin, and partial loss of free cholesterol transfer activities. Phosphatidylcholines 73-92 phospholipid transfer protein Mus musculus 36-40 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 80-99 cyclin dependent kinase 20 Homo sapiens 170-173 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 80-99 mitogen-activated protein kinase 1 Homo sapiens 178-181 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 101-103 heparan sulfate proteoglycan 2 Homo sapiens 134-137 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 101-103 cyclin dependent kinase 20 Homo sapiens 170-173 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 101-103 mitogen-activated protein kinase 1 Homo sapiens 178-181 10094474-2 1999 It was confirmed that the oxidation of human low density lipoprotein (LDL) by 15-LOX from rabbit reticulocytes gave phosphatidylcholine (PC) and cholesteryl ester (CE) hydroperoxides regio-, stereo- and enantio-specifically. Phosphatidylcholines 116-135 arachidonate 15-lipoxygenase Homo sapiens 78-84 10094474-2 1999 It was confirmed that the oxidation of human low density lipoprotein (LDL) by 15-LOX from rabbit reticulocytes gave phosphatidylcholine (PC) and cholesteryl ester (CE) hydroperoxides regio-, stereo- and enantio-specifically. Phosphatidylcholines 137-139 arachidonate 15-lipoxygenase Homo sapiens 78-84 10094474-3 1999 15-LOX also oxidized human plasma to give specific PC and CE hydroperoxides in spite of the presence of high concentrations of antioxidants. Phosphatidylcholines 51-53 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 0-6 10082810-3 1999 Among cells exposed to NGF (0-116 h), the labeling of DAG from [3H]glycerol peaked earlier than that of [3H]PC, and the specific radioactivity of [3H]glycerol-labeled DAG was much higher than those of the [3H]phospholipids, indicating that [3H]DAG synthesis precedes [3H]phospholipid synthesis. Phosphatidylcholines 108-110 nerve growth factor Rattus norvegicus 23-26 9989927-2 1999 This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-106 9989927-2 1999 This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 10082810-4 1999 NGF treatment also increased (by 50-330%) the incorporation of monounsaturated ([3H]oleic acid) and polyunsaturated ([14C]linoleic acid or [3H]arachidonic acid) fatty acids into DAG, and, by 15-70%, into PC. Phosphatidylcholines 204-206 nerve growth factor Rattus norvegicus 0-3 9920915-1 1999 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been proposed to play roles in numerous cellular pathways including signal transduction and membrane vesicular trafficking. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 10026263-4 1999 TF reconstituted into phosphatidylcholine vesicles was ineffective as a cofactor for the factor VIIa cleavage of factor V. However, incorporation of phosphatidylethanolamine in the vesicles had little effect over the presence of 20% phosphatidylserine. Phosphatidylcholines 22-41 coagulation factor III, tissue factor Homo sapiens 0-2 10030391-4 1999 In contrast with CETP, serum PLTP activity, as measured as the rate of radiolabeled phosphatidylcholine transferred from liposomes toward serum HDL, was significantly higher with the lauric acid diet (23.5+/2.6%) than with the palmitic acid diet (22.5+/-2.5%) (P = 0.0013), while no significant differences were noted when comparing the saturated diets versus the oleic acid diet (23.0+/-2.3%). Phosphatidylcholines 84-103 phospholipid transfer protein Homo sapiens 29-33 10075017-3 1999 When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609. Phosphatidylcholines 113-133 interleukin 1 beta Mus musculus 21-29 10048791-1 1999 Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils. Phosphatidylcholines 91-110 C-X-C motif chemokine ligand 8 Homo sapiens 29-42 10048791-1 1999 Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils. Phosphatidylcholines 91-110 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 10048791-3 1999 No studies have examined phospholipase D hydrolysis of the three subclasses of phosphatidylcholine in interleukin-8-stimulated neutrophils. Phosphatidylcholines 79-98 C-X-C motif chemokine ligand 8 Homo sapiens 102-115 10048791-7 1999 Our findings suggest that phospholipase D catalyses the hydrolysis of diacyl, alkylacyl and alkenylacyl subclasses of phosphatidylcholine in neutrophils upon IL-8 stimulation. Phosphatidylcholines 118-137 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 9914152-6 1999 For this study, the fluorescent sterol cholestatrienol (C-3) was incorporated into platelet membranes by exchange from cholesterol-containing phosphatidylcholine small unilamellar vesicles. Phosphatidylcholines 142-161 complement C3 Homo sapiens 56-59 10075017-3 1999 When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609. Phosphatidylcholines 113-133 transforming growth factor, beta 1 Mus musculus 31-39 10075017-3 1999 When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609. Phosphatidylcholines 113-133 perlecan (heparan sulfate proteoglycan 2) Mus musculus 164-167 9878788-9 1999 D609 which inhibits phosphatidylcholine-specific phospholipase-C (PLC), potently inhibited both CDP-DG accumulation and inositol phosphate formation. Phosphatidylcholines 20-39 cut-like homeobox 1 Rattus norvegicus 96-99 9989271-1 1999 Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Homo sapiens 94-138 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidylcholines 112-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidylcholines 112-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 9989271-1 1999 Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Homo sapiens 140-144 10728571-9 1999 PC biosynthesis seemed to be carried out through the CDP-choline pathway, which was stimulated in the oncogenic cells, whereas PE was more likely, a product of phosphatidylserine decarboxylation rather than the CDP-ethanolamine pathway. Phosphatidylcholines 0-2 cut like homeobox 1 Homo sapiens 53-56 9915331-8 1999 Propofol inhibited vasopressin-induced activation of phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D, but this effect of propofol was significant only at supraclinical concentration (0.1 mM). Phosphatidylcholines 102-121 arginine vasopressin Rattus norvegicus 19-30 9888879-7 1999 HDL3- and apolipoprotein (apo) A-I-mediated cellular cholesterol and phosphatidylcholine efflux was examined by labeling cells with [3H]cholesterol and [3H]choline, respectively, during growth and cholesterol loading during growth arrest. Phosphatidylcholines 69-88 HDL3 Homo sapiens 0-4 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 198-201 9854020-1 1999 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. Phosphatidylcholines 123-142 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 9854020-1 1999 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. Phosphatidylcholines 123-142 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 9854020-8 1999 PEMT activity decreased, the levels of PEMT2 mRNA decreased and there was an increase in the activity of CTP:phosphocholine cytidylyltransferase, a key regulatory enzyme in the CDP-choline pathway of phosphatidylcholine biosynthesis. Phosphatidylcholines 200-219 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-4 10192509-3 1999 LPC is formed by hydrolysis of phosphatidylcholine (PC) in LDL and cell membranes, induced by phospholipase A2 or by oxidation. Phosphatidylcholines 31-50 phospholipase A2 group IB Homo sapiens 94-110 9886255-6 1999 However, the phosphatidylcholine-specific PLC inhibitor D609 abrogates cell spreading without affecting adhesion to fibronectin in these cells as well as the CD3/CD28-activated T cells. Phosphatidylcholines 13-32 CD28 molecule Homo sapiens 162-166 10050072-0 1999 Endothelin-1 stimulates hydrolysis of phosphatidylcholine by phospholipases C and D in intact rat mesenteric arteries. Phosphatidylcholines 38-57 endothelin 1 Rattus norvegicus 0-12 10027763-3 1999 In lecithinized SOD, 4 molecules of a phosphatidylcholine derivative were covalently bound to each dimer of recombinant human copper-zinc SOD to facilitate tissue accumulation. Phosphatidylcholines 38-57 superoxide dismutase 1 Homo sapiens 16-19 10027763-3 1999 In lecithinized SOD, 4 molecules of a phosphatidylcholine derivative were covalently bound to each dimer of recombinant human copper-zinc SOD to facilitate tissue accumulation. Phosphatidylcholines 38-57 superoxide dismutase 1 Homo sapiens 138-141 9886817-1 1999 Studies were performed to determine the effects of PTH and related compounds on phosphatidylcholine (PC) hydrolysis in UMR-106 cells and the pathway by which the PTH effects occurred. Phosphatidylcholines 80-99 parathyroid hormone Rattus norvegicus 51-54 9867870-1 1999 The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 9867870-1 1999 The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments. Phosphatidylcholines 14-33 phospholipase D1 Homo sapiens 73-77 9867870-1 1999 The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments. Phosphatidylcholines 14-33 phospholipase D2 Homo sapiens 82-86 10025671-6 1999 The cytosolic PLA2 (cPLA2) inhibitor, arachidonyl trifluoromethyl ketone, was found to inhibit ATP-stimulated PC secretion, whereas the secretory PLA2 inhibitors, oleoyloxyethylphosphocholine, aristolochic acid, or p-bromophenacyl bromide, and the Ca2+-independent PLA2 inhibitors, palmitoyl trifluoromethyl ketone, or haloenol lactone suicide substrate, had no effect. Phosphatidylcholines 110-112 phospholipase A2 group IVA Rattus norvegicus 4-18 10025671-6 1999 The cytosolic PLA2 (cPLA2) inhibitor, arachidonyl trifluoromethyl ketone, was found to inhibit ATP-stimulated PC secretion, whereas the secretory PLA2 inhibitors, oleoyloxyethylphosphocholine, aristolochic acid, or p-bromophenacyl bromide, and the Ca2+-independent PLA2 inhibitors, palmitoyl trifluoromethyl ketone, or haloenol lactone suicide substrate, had no effect. Phosphatidylcholines 110-112 phospholipase A2 group IVA Rattus norvegicus 20-25 10192509-3 1999 LPC is formed by hydrolysis of phosphatidylcholine (PC) in LDL and cell membranes, induced by phospholipase A2 or by oxidation. Phosphatidylcholines 1-3 phospholipase A2 group IB Homo sapiens 94-110 10100195-9 1999 It is plausible that the decreased activity of phosphatidylethanolamine-N-methyltransferase and its low compensating ability could relate to the modification of phosphatidylcholine in brain tissues from Alzheimer"s disease patients. Phosphatidylcholines 161-180 phosphatidylethanolamine N-methyltransferase Homo sapiens 47-91 9861024-8 1998 Hepatic lipase may prevent such vesicular lipoproteins from accumulating in apo E-deficient mice by hydrolyzing phosphatidyl choline as scavenger receptor B1 removes the cholesteryl esters and by gradual endocytosis of lipoproteins bound to hepatic lipase on the surface of hepatocytes. Phosphatidylcholines 112-132 lipase, hepatic Mus musculus 0-14 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 protein kinase C alpha Homo sapiens 117-120 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 194-197 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 protein kinase C alpha Homo sapiens 117-120 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 301-304 9857049-7 1998 Pure ACAT-1 dispersed in mixed micelles containing sodium taurocholate, phosphatidylcholine, and cholesterol remains catalytically active. Phosphatidylcholines 72-91 acetyl-CoA acetyltransferase 1 Homo sapiens 5-11 9861024-8 1998 Hepatic lipase may prevent such vesicular lipoproteins from accumulating in apo E-deficient mice by hydrolyzing phosphatidyl choline as scavenger receptor B1 removes the cholesteryl esters and by gradual endocytosis of lipoproteins bound to hepatic lipase on the surface of hepatocytes. Phosphatidylcholines 112-132 lipase, hepatic Mus musculus 241-255 9858696-3 1998 Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight. Phosphatidylcholines 149-168 proteolipid protein 1 Homo sapiens 37-40 9841875-3 1998 Here it is shown that only in the presence of both Ca2+ and phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine can a prothrombin dimer be chemically cross-linked. Phosphatidylcholines 94-113 coagulation factor II, thrombin Homo sapiens 143-154 9858696-3 1998 Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight. Phosphatidylcholines 170-172 proteolipid protein 1 Homo sapiens 37-40 9858696-3 1998 Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight. Phosphatidylcholines 195-197 proteolipid protein 1 Homo sapiens 37-40 9826612-4 1998 For phosphatidylcholine also spin-labeled at the 8 position of the sn-2 chain, this ratio was reversed: the relaxation enhancement by Ni2+ ions was half that induced by molecular oxygen. Phosphatidylcholines 4-23 spindlin 1 Homo sapiens 29-33 9924985-4 1998 The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect. Phosphatidylcholines 57-76 phospholipase A2, group IB, pancreas Mus musculus 92-96 9826612-6 1998 For a double-labeled system, in which both N-biotinyl phosphatidylethanolamine and phosphatidylcholine were spin-labeled on the 12 C atom of the sn-2 chain, the relaxation rate in the absence of avidin was greater than that predicted from linear additivity of the corresponding singly labeled systems, because of mutual spin-spin interactions between the two labeled lipid species. Phosphatidylcholines 83-102 spindlin 1 Homo sapiens 108-112 9924985-4 1998 The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect. Phosphatidylcholines 78-80 phospholipase A2, group IB, pancreas Mus musculus 92-96 9885772-9 1998 In general, PC appears to promote the translocation of apo B from the cytosol to the lumen of the endoplasmic reticulum, a step that is crucial in the early stages of VLDL assembly. Phosphatidylcholines 12-14 apolipoprotein B Homo sapiens 55-60 9924985-6 1998 The results demonstrated that the arachidonic acid-containing PC and PA molecules induced a more pronounced increase of membrane-associated PLA2 activity in ras-transformed cells compared to the corresponding palmitate-stearate- or oleate- containing molecular species. Phosphatidylcholines 62-64 phospholipase A2, group IB, pancreas Mus musculus 140-144 10081149-2 1998 The result demonstrated the necessity of phosphatidylcholine (PC) for optimal ATPase activity and phosphatidylethanolamine (PE) for the optimal calcium transport activity. Phosphatidylcholines 41-60 dynein axonemal heavy chain 8 Homo sapiens 78-84 10081149-2 1998 The result demonstrated the necessity of phosphatidylcholine (PC) for optimal ATPase activity and phosphatidylethanolamine (PE) for the optimal calcium transport activity. Phosphatidylcholines 62-64 dynein axonemal heavy chain 8 Homo sapiens 78-84 9831630-0 1998 Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I. Phosphatidylcholines 73-92 apolipoprotein A1 Homo sapiens 154-172 9874205-1 1998 The SEC14 gene of Saccharomyces cerevisiae codes for a phosphatidylinositol-transfer protein (Sec14p(sc)) which is capable of transferring both phosphatidylinositol and phosphatidylcholine between membranes in vitro. Phosphatidylcholines 169-188 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 4-9 9874205-1 1998 The SEC14 gene of Saccharomyces cerevisiae codes for a phosphatidylinositol-transfer protein (Sec14p(sc)) which is capable of transferring both phosphatidylinositol and phosphatidylcholine between membranes in vitro. Phosphatidylcholines 169-188 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 94-100 9831631-1 1998 The microsomal triglyceride transfer protein (MTP) catalyzes the transfer of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces. Phosphatidylcholines 114-133 microsomal triglyceride transfer protein Homo sapiens 4-44 9831631-1 1998 The microsomal triglyceride transfer protein (MTP) catalyzes the transfer of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces. Phosphatidylcholines 114-133 microsomal triglyceride transfer protein Homo sapiens 46-49 9822688-11 1998 With this assay, we showed for the first time that rPLRP2 prefers phosphatidylglycerol and ethanolamine over phosphatidylcholine. Phosphatidylcholines 109-128 pancreatic lipase related protein 2 Rattus norvegicus 51-57 9879668-0 1998 The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. Phosphatidylcholines 87-106 tumor necrosis factor Rattus norvegicus 27-54 9879668-0 1998 The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. Phosphatidylcholines 87-106 interleukin 1 beta Rattus norvegicus 59-76 9879668-5 1998 These results suggest that tumor necrosis factor alpha or interleukin-1beta stimulate phosphatidylcholine secretion via protein kinase C activation in a Ca2+-independent manner. Phosphatidylcholines 86-105 tumor necrosis factor Rattus norvegicus 27-54 9879668-5 1998 These results suggest that tumor necrosis factor alpha or interleukin-1beta stimulate phosphatidylcholine secretion via protein kinase C activation in a Ca2+-independent manner. Phosphatidylcholines 86-105 interleukin 1 beta Rattus norvegicus 58-75 9804870-1 1998 The complexes of hemoglobin and cytochrome c with liposomes composed of phosphatidylcholine and its mixtures with cardiolipin and cholesterol have been studied by monitoring resonance energy transfer between fluorescent probe 3-methoxybenzanthrone as donor and heme groups of the proteins as acceptors. Phosphatidylcholines 72-91 cytochrome c, somatic Homo sapiens 32-44 9819208-2 1998 We report here new data concerning the nature of the interaction of apoA-I with condensed phospholipid (PL) monolayers (phosphatidylcholine and phosphatidylserine). Phosphatidylcholines 120-139 apolipoprotein A1 Homo sapiens 68-74 9862448-2 1998 Incorporation of [3H]palmitic acid into phosphatidylcholine (PC) and sphingomyelin (SM) was altered within 15-30 min after modifying the extracellular Mg2+ ion level ([Mg2+]o). Phosphatidylcholines 61-63 mucin 7, secreted Homo sapiens 151-154 9862448-2 1998 Incorporation of [3H]palmitic acid into phosphatidylcholine (PC) and sphingomyelin (SM) was altered within 15-30 min after modifying the extracellular Mg2+ ion level ([Mg2+]o). Phosphatidylcholines 61-63 mucin 7, secreted Homo sapiens 168-171 9792687-4 1998 We now report that the IGF-I-dependent increase in nuclear DAG production can be inhibited by the specific phosphatidylinositol phospholipase C inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine or by neomycin sulfate but not by the purported phosphatidylcholine-phospholipase C specific inhibitor D609 or by inhibitors of phospholipase D-mediated DAG generation. Phosphatidylcholines 254-273 insulin-like growth factor 1 Mus musculus 23-28 9813240-1 1998 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9786921-3 1998 Sphingomyelinase (SMase) and phospholipase A2 (PLA2) have been found in the arterial wall, and, moreover, lesional LDL shows signs of hydrolysis of both sphingomyelin and phosphatidylcholine. Phosphatidylcholines 171-190 phospholipase A2 group IB Homo sapiens 29-45 9815113-9 1998 In both control and dexamethasone-treated explants, TGF-beta1 (10 ng/ml) also decreased fatty acid synthetase mRNA, protein, and enzyme activity and the rate of [3H]choline incorporation into phosphatidylcholine. Phosphatidylcholines 192-211 transforming growth factor beta 1 Homo sapiens 52-61 9848395-10 1998 Furthermore, Rb1 reduces the phosphatidylcholine production by inhibiting the methyl-transferase I and II, and the reduction of phosphatidylcholine production inhibits leukotriene release. Phosphatidylcholines 29-48 LOW QUALITY PROTEIN: retinoblastoma-associated protein Cavia porcellus 13-16 9802889-3 1998 Mdr2-deficient mice lack Mdr2 P-glycoprotein, the canalicular translocator for phosphatidylcholine, and secrete virtually no phospholipid and cholesterol in bile. Phosphatidylcholines 79-98 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-4 9807043-8 1998 Simultaneously, we investigated sequential changes in the activities of phospholipase A2 and phospholipase C, which release peroxidized membrane phospholipids into the cytoplasm via hydrolysis, as well as the relationship between changes in the kidney tissue phospholipid composition (sphingomyelin/phosphatidylcholine ratio) and renal function. Phosphatidylcholines 299-318 phospholipase A2 group IB Rattus norvegicus 72-108 9786921-3 1998 Sphingomyelinase (SMase) and phospholipase A2 (PLA2) have been found in the arterial wall, and, moreover, lesional LDL shows signs of hydrolysis of both sphingomyelin and phosphatidylcholine. Phosphatidylcholines 171-190 phospholipase A2 group IB Homo sapiens 47-51 9774404-2 1998 We found that binding of heterotrimeric fVIIIa (A1.A2.A3-C1-C2) to synthetic vesicles with a physiologic content of 4% phosphatidylserine (PS), 76% phosphatidylcholine, and 20% phosphatidylethanolamine occurs with a 10-fold higher affinity than that of factor VIII (fVIII). Phosphatidylcholines 148-167 coagulation factor VIII Homo sapiens 40-45 9774472-4 1998 Whereas no abnormalities were observed in SP-D (+/-) mice, alveolar and tissue phosphatidylcholine pool sizes were markedly increased in SP-D (-/-) mice. Phosphatidylcholines 79-98 surfactant associated protein D Mus musculus 137-141 9774404-8 1998 This conclusion is based on the finding that binding of the monoclonal antibody ESH8 to the C2 domain, which is known to prevent this conformational transition, resulted in fVIIIa binding to PS/phosphatidylcholine/phosphatidylethanolamine vesicles (4/76/20) with a lower affinity similar to that of fVIII. Phosphatidylcholines 194-213 coagulation factor VIII Homo sapiens 173-178 9767142-0 1998 Unmyristoylated MARCKS-related protein (MRP) binds to supported planar phosphatidylcholine membranes. Phosphatidylcholines 71-90 MARCKS like 1 Homo sapiens 16-38 9778355-5 1998 The greatest degree of peptide 1H/2H exchange (95%) under nondenaturing conditions was found for the nAChR reconstituted into the highly fluid egg phosphatidylcholine membranes lacking cholesterol and anionic lipids at pH 9.0. Phosphatidylcholines 147-166 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 101-106 9765216-2 1998 Hepatocytes have a second pathway for the synthesis of phosphatidylcholine, a stepwise methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase and encoded by the Pempt gene. Phosphatidylcholines 55-74 phosphatidylethanolamine N-methyltransferase Mus musculus 205-210 9765216-3 1998 We report that when Pempt-deficient mice were fed a choline-deficient diet for 3 days, severe liver pathology occurred apparently due to a lack of phosphatidylcholine biosynthesis. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Mus musculus 20-25 9765216-6 1998 We suggest that the Pempt gene has been maintained during evolution to provide phosphatidylcholine when dietary choline is insufficient, as might occur during starvation or pregnancy. Phosphatidylcholines 79-98 phosphatidylethanolamine N-methyltransferase Mus musculus 20-25 9767142-0 1998 Unmyristoylated MARCKS-related protein (MRP) binds to supported planar phosphatidylcholine membranes. Phosphatidylcholines 71-90 MARCKS like 1 Homo sapiens 40-43 9748300-8 1998 Moreover, geranylgeraniol and farnesol induced a rapid inhibition of phosphatidylcholine biosynthesis at the last step of the CDP-choline pathway controlled by choline phosphotransferase and not at the level of CTP:phosphocholine cytidylyltransferase, the key enzyme of the pathway. Phosphatidylcholines 69-88 cut like homeobox 1 Homo sapiens 126-129 9746498-5 1998 With phosphatidylcholine as substrate, TNF-alpha decreased both cytosolic and membrane-associated iPLA2 activities. Phosphatidylcholines 5-24 tumor necrosis factor Rattus norvegicus 39-48 9767089-1 1998 The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues. Phosphatidylcholines 189-208 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 4-8 9767089-1 1998 The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues. Phosphatidylcholines 210-212 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 4-8 9767089-1 1998 The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues. Phosphatidylcholines 239-241 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 4-8 9767089-5 1998 These results suggest that PCs with short acyl residues were taken up by the cho1/pss mutant and remodeled as they were used, and that PCs with short acyl residues do not inhibit conversion of PE to PC. Phosphatidylcholines 27-29 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 77-81 9755106-5 1998 Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin. Phosphatidylcholines 64-83 phospholipase A2 group X Homo sapiens 47-52 9755106-5 1998 Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin. Phosphatidylcholines 85-87 phospholipase A2 group X Homo sapiens 47-52 9746498-5 1998 With phosphatidylcholine as substrate, TNF-alpha decreased both cytosolic and membrane-associated iPLA2 activities. Phosphatidylcholines 5-24 phospholipase A2 group VI Rattus norvegicus 98-103 9799116-5 1998 Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho). Phosphatidylcholines 138-157 phospholipase C delta 3 Homo sapiens 47-57 9763531-11 1998 Over 24 hours, human apolipoprotein (apo) A-I, apoHDL reconstituted with phosphatidylcholine, and HDL3 respectively removed 46.6+/-3.7%, 61. Phosphatidylcholines 73-92 apolipoprotein A1 Homo sapiens 21-45 9788614-2 1998 After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids. Phosphatidylcholines 178-197 phospholipase A2, group IB, pancreas Mus musculus 102-118 9788614-2 1998 After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids. Phosphatidylcholines 178-197 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 120-125 9876331-11 1998 During stimulation with endothelin-1 and phorbolester, but not phenylephrine, phosphatidylcholine becomes an increasingly important source for 1,2-diacylglycerol due to sustained activation of phospholipase D. The 1,2-diacylglycerol level remains relatively constant during agonist stimulation which strongly indicates that particular molecular species of 1,2-diacylglycerol more than its total concentration determine the activation of protein kinase C isoenzymes. Phosphatidylcholines 78-97 endothelin 1 Rattus norvegicus 24-36 9799116-5 1998 Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho). Phosphatidylcholines 159-165 phospholipase C delta 3 Homo sapiens 47-57 9802015-9 1998 The proportion of the predominant phospholipid, phosphatidylcholine, exhibited a profile that was the inverse of the phosphatidylinositol content: phosphatidylcholine content was lowest in opi1 cells in stationary phase. Phosphatidylcholines 48-67 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 189-193 9788244-0 1998 Submicellar bile salts stimulate phosphatidylcholine transfer activity of sterol carrier protein 2. Phosphatidylcholines 33-52 sterol carrier protein 2 Homo sapiens 74-98 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9802015-9 1998 The proportion of the predominant phospholipid, phosphatidylcholine, exhibited a profile that was the inverse of the phosphatidylinositol content: phosphatidylcholine content was lowest in opi1 cells in stationary phase. Phosphatidylcholines 147-166 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 189-193 9873837-1 1998 Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation by GPC: choline phosphodiesterase (GPC: choline PDE). Phosphatidylcholines 113-132 phospholipase A2 group IB Canis lupus familiaris 164-180 9798980-3 1998 The interaction of beta2-GPI with unilamellar vesicles containing varying amounts of acidic phospholipids with phosphatidylcholine (PC) was measured at equilibrium via relative light scattering. Phosphatidylcholines 111-130 apolipoprotein H Homo sapiens 19-28 9798980-3 1998 The interaction of beta2-GPI with unilamellar vesicles containing varying amounts of acidic phospholipids with phosphatidylcholine (PC) was measured at equilibrium via relative light scattering. Phosphatidylcholines 132-134 apolipoprotein H Homo sapiens 19-28 9873837-1 1998 Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation by GPC: choline phosphodiesterase (GPC: choline PDE). Phosphatidylcholines 113-132 phospholipase A2 group IB Canis lupus familiaris 182-186 9748327-8 1998 Although this enzyme shows a modest ( approximately 50%) reduction in activity when anionic substrates are used under standard assay conditions, the activity of the enzyme on phosphatidylcholine vesicles and cell membranes is dramatically increased compared with human sPLA2. Phosphatidylcholines 175-194 phospholipase A2 group IIA Homo sapiens 269-274 9753449-0 1998 Modulation of the positional specificity of lecithin-cholesterol acyltransferase by the acyl group composition of its phosphatidylcholine substrate: role of the sn-1-acyl group. Phosphatidylcholines 118-137 lecithin-cholesterol acyltransferase Homo sapiens 44-80 9753449-1 1998 Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6. Phosphatidylcholines 103-122 lecithin-cholesterol acyltransferase Homo sapiens 6-42 9753449-1 1998 Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6. Phosphatidylcholines 103-122 lecithin-cholesterol acyltransferase Homo sapiens 44-48 9753449-1 1998 Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6. Phosphatidylcholines 124-126 lecithin-cholesterol acyltransferase Homo sapiens 6-42 9753449-1 1998 Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6. Phosphatidylcholines 124-126 lecithin-cholesterol acyltransferase Homo sapiens 44-48 9727944-3 1998 The most significant changes were increases in the concentration of the glycolytic intermediate, fructose-1,6-bisphosphate and in the concentration of CDP-choline, which is an intermediate in phosphatidylcholine biosynthesis. Phosphatidylcholines 192-211 cut like homeobox 1 Homo sapiens 151-154 9735345-2 1998 On phosphatidylcholine or especially dipalmitoylphosphatidylcholine monolayers, SP-A at roughly 0.005 mg/ml formed large numbers of fibers and elaborate fibrous networks. Phosphatidylcholines 3-22 pulmonary surfactant-associated protein A Bos taurus 80-84 9726932-5 1998 Reconstitution of rhodopsin into phosphatidylcholine vesicles has little influence on the spectral properties of the rhodopsin-transducin complex, whereas pH affects the intensity of the carbonyl stretching band. Phosphatidylcholines 33-52 rhodopsin Bos taurus 18-27 9724516-8 1998 Studies on the influence of quinacrine on the activity of PLA2 toward pyrene-labeled phospholipid analogues revealed that the hydrolysis of phosphatidylcholine was progressively reduced as a function of increasing [quinacrine]. Phosphatidylcholines 140-159 phospholipase A2 group IB Homo sapiens 58-62 9705332-6 1998 Interestingly, cPLA2-gamma demonstrates a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. Phosphatidylcholines 98-117 phospholipase A2 group IVC Homo sapiens 15-26 9784877-1 1998 The structural features of apolipoprotein A1 (apoA1) that provide for the formation of its stable micellar complexes with phosphatidylcholine are discussed. Phosphatidylcholines 122-141 apolipoprotein A1 Homo sapiens 27-44 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. Phosphatidylcholines 237-256 nerve growth factor Rattus norvegicus 84-103 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. Phosphatidylcholines 237-256 nerve growth factor Rattus norvegicus 105-108 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. Phosphatidylcholines 67-69 nerve growth factor Rattus norvegicus 84-103 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. Phosphatidylcholines 67-69 nerve growth factor Rattus norvegicus 105-108 9784877-1 1998 The structural features of apolipoprotein A1 (apoA1) that provide for the formation of its stable micellar complexes with phosphatidylcholine are discussed. Phosphatidylcholines 122-141 apolipoprotein A1 Homo sapiens 46-51 9784877-3 1998 The preparation procedures for discoidal micellar complexes of apoA1 with phosphatidylcholine are discussed, and the characteristics of the complexes are described. Phosphatidylcholines 74-93 apolipoprotein A1 Homo sapiens 63-68 9692961-1 1998 Bilayers composed of phosphatidylcholine initially resist catalysis by phospholipase A2. Phosphatidylcholines 21-40 phospholipase A2 group IB Homo sapiens 71-87 9683538-10 1998 Treatment of F3II cells, with phorbol myristate acetate (PMA) or phosphatidic acid (PA, the product of PLD-dependent hydrolysis of phosphatidylcholine), significantly enhanced CD44 expression. Phosphatidylcholines 131-150 CD44 antigen Mus musculus 176-180 9696021-0 1998 Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice. Phosphatidylcholines 90-109 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 44-48 9696021-1 1998 Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile. Phosphatidylcholines 176-195 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 40-44 9820649-2 1998 The activation of phospholipases A2, C and D (PLA2, PLC and PLD) acting on phosphatidylcholine and phosphatidylethanolamine was determined by high performance liquid chromatography (HPLC) separation and liquid scintillation counting of water- and lipid-soluble phospholipid metabolites. Phosphatidylcholines 75-94 LOC104974671 Bos taurus 18-44 9685717-0 1998 Reactivity of soybean lipoxygenase-1 to linoleic acid entrapped in phosphatidylcholine vesicles. Phosphatidylcholines 67-86 seed linoleate 13S-lipoxygenase-1 Glycine max 22-36 9733153-7 1998 The intake of n-3 PUFA was checked by red blood cell (RBC) phosphatidylcholine (PC) fatty acid composition. Phosphatidylcholines 59-78 pumilio RNA binding family member 3 Homo sapiens 18-22 9733153-7 1998 The intake of n-3 PUFA was checked by red blood cell (RBC) phosphatidylcholine (PC) fatty acid composition. Phosphatidylcholines 80-83 pumilio RNA binding family member 3 Homo sapiens 18-22 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 11-15 9668079-6 1998 Cells expressing the E161K mutation in the URA7-encoded CTP synthetase exhibited an increase (1.5-fold) in the utilization of the Kennedy pathway for phosphatidylcholine synthesis when compared with control cells. Phosphatidylcholines 150-169 CTP synthase URA7 Saccharomyces cerevisiae S288C 43-47 9681053-9 1998 The HPLAPs were selectively incorporated into liposomes consisting of phosphatidylcholine/cholesterol, and most of the PIPL-D-treated PLAP could from HPLAPs, while a small amount of PLAP could not form HPLAPs. Phosphatidylcholines 70-89 alkaline phosphatase, placental Homo sapiens 5-9 9681053-9 1998 The HPLAPs were selectively incorporated into liposomes consisting of phosphatidylcholine/cholesterol, and most of the PIPL-D-treated PLAP could from HPLAPs, while a small amount of PLAP could not form HPLAPs. Phosphatidylcholines 70-89 alkaline phosphatase, placental Homo sapiens 134-138 9721630-1 1998 The interaction of the amphoteric surfactant N-dodecyl-N,N-dimethylbetaine (C12-Bet) with phosphatidylcholine (PC) liposomes was investigated. Phosphatidylcholines 90-109 delta/notch like EGF repeat containing Homo sapiens 80-83 9721630-1 1998 The interaction of the amphoteric surfactant N-dodecyl-N,N-dimethylbetaine (C12-Bet) with phosphatidylcholine (PC) liposomes was investigated. Phosphatidylcholines 111-113 delta/notch like EGF repeat containing Homo sapiens 80-83 9688933-5 1998 A2R inhibited cell association of 125I-SP-A to type II cells plated on Transwell membranes as well as those plated on plastic dishes and also inhibited the SP-A-stimulated incorporation of phosphatidylcholine liposomes into type II cells. Phosphatidylcholines 189-208 surfactant protein A1 Homo sapiens 156-160 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phosphatidylcholines 14-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 24-39 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phosphatidylcholines 14-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-44 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 17-21 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 27-31 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 107-112 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 143-148 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 143-148 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 169-173 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 143-148 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 189-193 9642212-2 1998 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Phosphatidylcholines 64-83 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 143-148 9642212-8 1998 We also propose that phospholipase D1-mediated phosphatidylcholine turnover generates a signal that activates transcription of INO1, the structural gene for inositol 1-phosphate synthase. Phosphatidylcholines 47-66 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 127-131 9684747-2 1998 We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA. Phosphatidylcholines 241-260 lecithin-cholesterol acyltransferase Homo sapiens 75-111 9684747-2 1998 We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA. Phosphatidylcholines 241-260 lecithin-cholesterol acyltransferase Homo sapiens 113-117 9684747-2 1998 We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA. Phosphatidylcholines 262-264 lecithin-cholesterol acyltransferase Homo sapiens 75-111 9684747-2 1998 We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA. Phosphatidylcholines 262-264 lecithin-cholesterol acyltransferase Homo sapiens 113-117 9684747-7 1998 Thus, for human LCAT, 18:1t was more inhibitory when present at sn-2 position of PC, than at sn-1, when paired with 16:0. Phosphatidylcholines 81-83 lecithin-cholesterol acyltransferase Homo sapiens 16-20 9748733-4 1998 The objective of the present study was to assess how the fatty acid composition in plasma phosphatidyl choline affects the total and LDL cholesterol, triglyceride and apolipoprotein B concentrations in subjects with primary hyperlipoproteinaemia and dyslipidaemia. Phosphatidylcholines 90-110 apolipoprotein B Homo sapiens 167-183 9649332-1 1998 Pulmonary surfactant-associated protein B (SP-B) has been isolated from porcine lungs and reconstituted in bilayers of dipalmitoylphosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) to characterize the extent of insertion of the protein into phospholipid bilayers. Phosphatidylcholines 130-149 surfactant protein B Homo sapiens 0-41 9649332-1 1998 Pulmonary surfactant-associated protein B (SP-B) has been isolated from porcine lungs and reconstituted in bilayers of dipalmitoylphosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) to characterize the extent of insertion of the protein into phospholipid bilayers. Phosphatidylcholines 153-155 surfactant protein B Homo sapiens 0-41 9649332-2 1998 The parameters for the interaction of SP-B with DPPC or PC using different reconstitution protocols have been estimated from the changes induced in the fluorescence emission spectrum of the single protein tryptophan. Phosphatidylcholines 50-52 surfactant protein B Homo sapiens 38-42 9748733-10 1998 CONCLUSIONS: The submitted results indicate that the fatty acid concentrations of PC in plasma are significantly and markedly correlated with concentrations of total cholesterol, triglycerides, LDL-cholesterol and apolipoprotein B. Phosphatidylcholines 82-84 apolipoprotein B Homo sapiens 214-230 9649332-5 1998 SP-B tryptophan was found to be located 10-13 A from the center of bilayers, which is consistent with a superficial location of SP-B in phosphatidylcholine membranes. Phosphatidylcholines 136-155 surfactant protein B Homo sapiens 0-4 9636222-1 1998 Phosphatidylcholine-specific phospholipase C (PC-PLC) is a necessary intermediate in transducing apoptotic signals for tumor necrosis factor and Fas/Apo-1 ligands in nonneuronal cells. Phosphatidylcholines 0-19 Fas cell surface death receptor Homo sapiens 149-154 9649332-5 1998 SP-B tryptophan was found to be located 10-13 A from the center of bilayers, which is consistent with a superficial location of SP-B in phosphatidylcholine membranes. Phosphatidylcholines 136-155 surfactant protein B Homo sapiens 128-132 9787801-12 1998 These results indicate isolation from bovine lung of a 29 kDa acidic Ca(2+)-independent phospholipase A2 homologue of the rat and human enzyme and provide evidence for specificity in the metabolism of lung surfactant phosphatidylcholine. Phosphatidylcholines 217-236 LOC104974671 Bos taurus 88-104 9622504-4 1998 The binding of cPLA2 to phosphatidylcholine vesicles is mostly governed by its C2 domain; binding is relatively weak, and calcium enhances binding and interfacial catalysis by about 10-fold. Phosphatidylcholines 24-43 phospholipase A2 group IVA Homo sapiens 15-20 9601059-2 1998 Previously we showed that stimulation of phosphatidylcholine (PtdCho) synthesis by PMA in SK-N-MC human neuroblastoma cells required overexpression of MARCKS, whereas PKCalpha alone was insufficient. Phosphatidylcholines 41-60 myristoylated alanine rich protein kinase C substrate Homo sapiens 151-157 9601059-2 1998 Previously we showed that stimulation of phosphatidylcholine (PtdCho) synthesis by PMA in SK-N-MC human neuroblastoma cells required overexpression of MARCKS, whereas PKCalpha alone was insufficient. Phosphatidylcholines 62-68 myristoylated alanine rich protein kinase C substrate Homo sapiens 151-157 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 62-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 130-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 130-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 201-204 9601059-10 1998 Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response. Phosphatidylcholines 84-90 myristoylated alanine rich protein kinase C substrate Homo sapiens 22-28 9601059-10 1998 Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response. Phosphatidylcholines 84-90 protein kinase C alpha Homo sapiens 57-60 9601059-10 1998 Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response. Phosphatidylcholines 84-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 9630635-9 1998 The results indicate that TNF specifically modulates the kinetics of membrane-bound enzymes of the rate determining steps in phosphatidylcholine biosynthesis, possibly as part of early events involved in apoptosis. Phosphatidylcholines 125-144 tumor necrosis factor Homo sapiens 26-29 9622488-2 1998 This facilitates lipase adsorption to phosphatidylcholine-rich interfaces, presumably as a consequence of the higher affinity of colipase for such interfaces. Phosphatidylcholines 38-57 colipase Homo sapiens 129-137 9572479-5 1998 Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling. Phosphatidylcholines 23-42 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-78 9581864-1 1998 In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively. Phosphatidylcholines 115-134 interleukin 6 Mus musculus 278-291 9581864-1 1998 In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively. Phosphatidylcholines 115-134 interleukin 6 Mus musculus 293-297 9572479-5 1998 Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling. Phosphatidylcholines 23-42 early growth response 1 Rattus norvegicus 83-88 9572479-5 1998 Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling. Phosphatidylcholines 23-42 5-hydroxytryptamine receptor 2A Rattus norvegicus 146-152 9643351-0 1998 Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2. Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 0-16 9626147-10 1998 Lyso PtdCho, a product derived from phospholipase A2 action on peroxidized phosphatidylcholine and a potent chemotactic factor for monocytes and T-lymphocytes, is elevated in endometriosis. Phosphatidylcholines 75-94 phospholipase A2 group IB Homo sapiens 36-52 11324575-2 1998 The results showed that ET-1 (10(-12) and 10(-10) mol/L) increased the basal secretion of total phospholipids (TP) and phosphatidylcholine (PC), and potentiated the stimulatory effect of intermittent lung inflation on the secretion of TP and PC. Phosphatidylcholines 119-138 endothelin 1 Rattus norvegicus 24-28 11324575-2 1998 The results showed that ET-1 (10(-12) and 10(-10) mol/L) increased the basal secretion of total phospholipids (TP) and phosphatidylcholine (PC), and potentiated the stimulatory effect of intermittent lung inflation on the secretion of TP and PC. Phosphatidylcholines 140-142 endothelin 1 Rattus norvegicus 24-28 9593672-2 1998 Guinea pig intestinal phospholipase B is a calcium-independent phospholipase hydrolyzing sequentially the acyl ester bonds at sn-2 and sn-1 positions of glycerophospholipids, promoting the formation of sn-glycero-3-phosphocholine from phosphatidylcholine. Phosphatidylcholines 235-254 phospholipase B1, membrane-associated Cavia porcellus 22-37 9593849-4 1998 In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold). Phosphatidylcholines 85-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 9593753-1 1998 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulator of phosphatidylcholine biosynthesis, and only a single isoform of this enzyme, CCTalpha, is known. Phosphatidylcholines 68-87 phosphate cytidylyltransferase 1A, choline Homo sapiens 144-152 9593753-8 1998 Transfection of COS-7 cells with a CCTbeta expression construct led to the overexpression of CCT activity, the accumulation of cellular CDP-choline, and enhanced radiolabeling of phosphatidylcholine. Phosphatidylcholines 179-198 phosphate cytidylyltransferase 1B, choline Homo sapiens 35-42 9593849-0 1998 Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D. Phosphatidylcholines 29-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-129 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-41 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 154-173 protein kinase C alpha Homo sapiens 22-25 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 154-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 154-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 175-181 protein kinase C alpha Homo sapiens 22-25 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 175-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 175-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 9593849-2 1998 Here, attached and suspended NIH 3T3 fibroblasts as well as variants of the MCF-7 human breast carcinoma cell line expressing PKC-alpha and a PtdCho-specific PLD activity at widely different levels were used to determine the possible role of PKC-alpha, PtdCho hydrolysis, and choline uptake in the mediation of PMA effect on PtdCho synthesis. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-161 9585574-4 1998 In the present study, Fourier transform infrared spectroscopy (FTIR) has been used to monitor the hydrolysis of phosphatidylcholine by phospholipase A2 (PLA2) from Naja mocambique mocambique venom in the presence of various aminoglycosides and/or daptomycin. Phosphatidylcholines 112-131 phospholipase A2 group IB Homo sapiens 135-151 9585574-4 1998 In the present study, Fourier transform infrared spectroscopy (FTIR) has been used to monitor the hydrolysis of phosphatidylcholine by phospholipase A2 (PLA2) from Naja mocambique mocambique venom in the presence of various aminoglycosides and/or daptomycin. Phosphatidylcholines 112-131 phospholipase A2 group IB Homo sapiens 153-157 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 9564846-4 1998 GLP-1(7-36)amide stimulated phosphatidylcholine secretion in a concentration-dependent manner in the 1-100 nM range; the concentration of the peptide that produced a half-maximal response was 10 nM. Phosphatidylcholines 28-47 glucagon Rattus norvegicus 0-5 9560313-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, generating phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9648220-5 1998 This Amadori product formation was also confirmed in PE/phosphate buffer dispersions and in phosphatidylcholine-PE liposome/phosphate buffer suspensions in the presence of D-glucose at 37 degrees C. gPE was degraded by phospholipase A2, C and D. Phosphatidylcholines 92-111 phospholipase A2 group IB Homo sapiens 219-244 9648224-7 1998 iii) Oxidized phosphatidylcholine, but not oxidized cholesterol, in the vesicles affected LCAT activity. Phosphatidylcholines 14-33 lecithin-cholesterol acyltransferase Homo sapiens 90-94 9648224-9 1998 These results suggest that the esterification of cholesterol by LCAT may be affected by the oxidation of substrate phosphatidylcholine via free radical generation in the plasma. Phosphatidylcholines 115-134 lecithin-cholesterol acyltransferase Homo sapiens 64-68 9564846-8 1998 A study of the mechanism through which GLP-1-(7-36)amide exerts its stimulatory effect was carried out using different agents that are well known stimulants of phosphatidylcholine secretion. Phosphatidylcholines 160-179 glucagon Rattus norvegicus 39-44 9556620-7 1998 PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1. Phosphatidylcholines 204-223 serpin family A member 5 Homo sapiens 0-3 9596995-5 1998 In addition, we have found that D609, a specific inhibitor of phosphatidylcholine-specific phospholipase C, also inhibits IL-3-induced expression of the bcl-2 gene without affecting IL-3-induced tyrosine phosphorylation. Phosphatidylcholines 62-81 interleukin 3 Homo sapiens 122-126 9596995-5 1998 In addition, we have found that D609, a specific inhibitor of phosphatidylcholine-specific phospholipase C, also inhibits IL-3-induced expression of the bcl-2 gene without affecting IL-3-induced tyrosine phosphorylation. Phosphatidylcholines 62-81 BCL2 apoptosis regulator Homo sapiens 153-158 9573065-3 1998 Incubation of isolated neutrophils with [3H]AA resulted in incorporation of radioactivity in the PLA2 substrates phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine. Phosphatidylcholines 113-132 LOC104974671 Bos taurus 97-101 9562607-1 1998 The interaction and orientation of a membrane protein ion channel model, an alpha-aminoisobutyric acid analogue of gramicidin B (GBA), in egg yolk phosphatidylcholine vesicles was studied by means of fluorescence spectroscopic techniques. Phosphatidylcholines 147-166 glucosylceramidase beta Homo sapiens 129-132 9848183-1 1998 Kinetics of methemoglobin structural changes in the complex with liposomes composed of phosphatidylcholine and its mixtures with cardiolipin has been studied. Phosphatidylcholines 87-106 hemoglobin subunit gamma 2 Homo sapiens 12-25 9610765-10 1998 Compared to eight normal fibroblast cell lines, homogenates and culture media of four TD fibroblast cell lines were reduced by 40-50% and 30-35%, respectively, in their activity to transfer PC, PI, or PE onto apoA-I. Phosphatidylcholines 190-192 apolipoprotein A1 Homo sapiens 209-215 9585013-2 1998 PTHrP stimulates phosphatidylcholine synthesis in rat fetal lung explants, suggesting a role in fetal type II alveolar maturation and surfactant production. Phosphatidylcholines 17-36 parathyroid hormone-like hormone Rattus norvegicus 0-5 9643439-1 1998 The aim of this study was to investigate if the effective in-situ permeability (Peff) of a new growth hormone-releasing peptide, hexarelin, along rat intestine was enhanced by a lipid matrix drug-delivery system comprising a mixture of soybean phosphatidyl choline and medium-chain monoacylglycerol (PC-MG). Phosphatidylcholines 244-264 ghrelin and obestatin prepropeptide Rattus norvegicus 95-127 9553075-11 1998 A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles. Phosphatidylcholines 175-194 secretoglobin family 2B member 3, pseudogene Homo sapiens 47-50 9553075-11 1998 A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles. Phosphatidylcholines 175-194 rabphilin 3A Homo sapiens 160-171 9555096-7 1998 Hydrolysis of mixed vesicles containing phosphatidylserine and phosphatidylcholine by the venom and pancreatic enzymes were differentially inhibited by annexin V. Phosphatidylcholines 63-82 annexin A5 Homo sapiens 152-161 9555096-9 1998 In contrast, the venom enzyme is able to readily hydrolyse phosphatidylcholine domains that would be minimally affected by annexin V. Phosphatidylcholines 59-78 annexin A5 Homo sapiens 123-132 9555099-6 1998 After extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at 2490 cm-1 as a B-H band in the mixture of BSH with phosphatidylcholine, which is attributed to a BSH-phosphatidylcholine complex, which could dissolve well in CCl4. Phosphatidylcholines 141-160 C-C motif chemokine ligand 4 Homo sapiens 44-48 9555099-6 1998 After extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at 2490 cm-1 as a B-H band in the mixture of BSH with phosphatidylcholine, which is attributed to a BSH-phosphatidylcholine complex, which could dissolve well in CCl4. Phosphatidylcholines 141-160 C-C motif chemokine ligand 4 Homo sapiens 249-253 9531469-4 1998 First, hV-PLA2 can catalyse the hydrolysis of phosphatidylcholine more effectively than hIIa-PLA2 by two orders of magnitude. Phosphatidylcholines 46-65 phospholipase A2 group V Homo sapiens 7-14 9555099-7 1998 The molar ratio of BSH to phosphatidylcholine in the CCl4 solution was at most one mole of BSH to two moles of phosphatidylcholine independent of the excess BSH. Phosphatidylcholines 26-45 C-C motif chemokine ligand 4 Homo sapiens 53-57 9555099-7 1998 The molar ratio of BSH to phosphatidylcholine in the CCl4 solution was at most one mole of BSH to two moles of phosphatidylcholine independent of the excess BSH. Phosphatidylcholines 111-130 C-C motif chemokine ligand 4 Homo sapiens 53-57 9531469-4 1998 First, hV-PLA2 can catalyse the hydrolysis of phosphatidylcholine more effectively than hIIa-PLA2 by two orders of magnitude. Phosphatidylcholines 46-65 phospholipase A2 group IB Homo sapiens 10-14 9531469-5 1998 Secondly, hV-PLA2 has much higher binding affinity and activity for compactly packed phosphatidylcholine bilayers than hIIa-PLA2. Phosphatidylcholines 85-104 phospholipase A2 group V Homo sapiens 10-17 9531469-5 1998 Secondly, hV-PLA2 has much higher binding affinity and activity for compactly packed phosphatidylcholine bilayers than hIIa-PLA2. Phosphatidylcholines 85-104 phospholipase A2 group IB Homo sapiens 13-17 9535751-2 1998 The PLD activity was measured by phosphatidylethanol produced from radiolabeled phosphatidylcholine or myristic acid in the presence of ethanol. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 9535891-7 1998 APC and the chimera bound to phosphatidylserine:phosphatidylcholine vesicles with similar affinity (Kd approximately 500 nM), and PE increased affinity 2-3-fold. Phosphatidylcholines 48-67 APC regulator of WNT signaling pathway Homo sapiens 0-3 9657274-2 1998 Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. Phosphatidylcholines 135-154 mannose binding lectin 2 Homo sapiens 6-27 9657274-2 1998 Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. Phosphatidylcholines 135-154 mannose binding lectin 2 Homo sapiens 29-32 9657274-2 1998 Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. Phosphatidylcholines 156-158 mannose binding lectin 2 Homo sapiens 6-27 9657274-2 1998 Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. Phosphatidylcholines 156-158 mannose binding lectin 2 Homo sapiens 29-32 9551426-4 1998 MDR2 Pgp is exclusively a phosphatidylcholine translocase. Phosphatidylcholines 26-45 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 9551426-4 1998 MDR2 Pgp is exclusively a phosphatidylcholine translocase. Phosphatidylcholines 26-45 phosphoglycolate phosphatase Homo sapiens 5-8 9555056-1 1998 Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma). Phosphatidylcholines 0-19 fibroblast growth factor 2 Rattus norvegicus 47-77 9555056-1 1998 Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma). Phosphatidylcholines 0-19 fibroblast growth factor 2 Rattus norvegicus 79-83 9555056-1 1998 Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma). Phosphatidylcholines 21-23 fibroblast growth factor 2 Rattus norvegicus 47-77 9555056-1 1998 Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma). Phosphatidylcholines 21-23 fibroblast growth factor 2 Rattus norvegicus 79-83 9538008-1 1998 Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified. Phosphatidylcholines 31-50 phospholipase D1 Homo sapiens 83-86 9538008-1 1998 Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified. Phosphatidylcholines 31-50 phospholipase D1 Homo sapiens 89-93 9538008-1 1998 Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified. Phosphatidylcholines 31-50 phospholipase D2 Homo sapiens 98-102 9556135-0 1998 Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C. We previously showed that prostaglandin E2 (PGE2) stimulates multiple intracellular signaling pathways as follows: by activation of adenylate cyclase; phosphoinositide (PI)-hydrolyzing phospholipase C and phosphatidylcholine (PC)-hydrolyzing phospholipase D; and by induction of Ca2+ influx in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 322-324 interleukin 6 Mus musculus 0-13 9516439-7 1998 In membranes of HEK-293 cells pretreated with TcdB-1470 or TcsL, basal and stable GTP analog-stimulated PLD activities measured with exogenous phosphatidylcholine, in the presence or absence of phosphatidylinositol 4,5-bisphosphate, were not altered. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 104-107 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-95 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-100 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-95 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-100 9506955-4 1998 We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220. Phosphatidylcholines 187-206 nuclear factor kappa B subunit 1 Homo sapiens 98-107 9506955-4 1998 We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220. Phosphatidylcholines 187-206 tumor necrosis factor Homo sapiens 135-144 9506985-1 1998 Lysophosphatidylcholine (lyso-PC) is a product of phosphatidylcholine hydrolysis by phospholipase A2 (PLA2) and is present in cell membranes, oxidized lipoproteins, and atherosclerotic tissues. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 84-100 9506985-1 1998 Lysophosphatidylcholine (lyso-PC) is a product of phosphatidylcholine hydrolysis by phospholipase A2 (PLA2) and is present in cell membranes, oxidized lipoproteins, and atherosclerotic tissues. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 102-106 9506955-4 1998 We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220. Phosphatidylcholines 187-206 interleukin 1 beta Homo sapiens 149-157 9497326-6 1998 Here we demonstrate that this reducing activity extended to hydroperoxides of phosphatidylcholine, was similar in HDL2 and HDL3, was independent of arylesterase and lecithin:cholesteryl acyltransferase activity, was unaffected by sulfhydryl reagents, and was expressed by reconstituted particles containing apoAI or apoAII only, as well as isolated human apoAI. Phosphatidylcholines 78-97 apolipoprotein A2 Homo sapiens 316-322 9494101-6 1998 Like LDL-PLA2, HSD-PLA2 was able to hydrolyse oxidatively modified phosphatidylcholines when supplemented to human LDL prior to copper-stimulated oxidation. Phosphatidylcholines 67-87 phospholipase A2 group VII Homo sapiens 5-13 9494101-6 1998 Like LDL-PLA2, HSD-PLA2 was able to hydrolyse oxidatively modified phosphatidylcholines when supplemented to human LDL prior to copper-stimulated oxidation. Phosphatidylcholines 67-87 platelet activating factor acetylhydrolase 2 Homo sapiens 15-23 9497326-13 1998 We conclude that the oxidation of specific Met residues of apoAI and apoAII to Met(O) plays a significant role in the 2-electron reduction of hydroperoxides of cholesteryl esters and phosphatidylcholine associated with human HDL. Phosphatidylcholines 183-202 apolipoprotein A2 Homo sapiens 69-75 9488694-8 1998 Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM. Phosphatidylcholines 16-35 apolipoprotein E Homo sapiens 72-76 9488694-8 1998 Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM. Phosphatidylcholines 16-35 apolipoprotein E Homo sapiens 131-135 9477969-0 1998 Influence of annexin V on the structure and dynamics of phosphatidylcholine/phosphatidylserine bilayers: a fluorescence and NMR study. Phosphatidylcholines 56-75 annexin A5 Homo sapiens 13-22 9521652-1 1998 The interaction of tissue factor pathway inhibitor (TFPI), factor Xa, and TFPI-factor Xa complexes with negatively charged phospholipid membranes composed of 25 mol % phosphatidylserine and 75 mol % phosphatidylcholine was studied by ellipsometry. Phosphatidylcholines 199-218 coagulation factor X Homo sapiens 79-88 9547904-3 1998 Its enzymatic properties are distinct from those of well characterized phospholipase A2 enzymes; by using a series of synthetic phosphatidylcholines, the enzyme cleaved oleic, linoleic, and arachidonic acids like phospholipase A2, and released palmitic and stearic acids like phospholipase A1. Phosphatidylcholines 128-148 phospholipase A2 group IB Rattus norvegicus 71-87 9547904-3 1998 Its enzymatic properties are distinct from those of well characterized phospholipase A2 enzymes; by using a series of synthetic phosphatidylcholines, the enzyme cleaved oleic, linoleic, and arachidonic acids like phospholipase A2, and released palmitic and stearic acids like phospholipase A1. Phosphatidylcholines 128-148 phospholipase A2 group IB Rattus norvegicus 213-229 9473293-7 1998 Mouse ACBP also inhibited microsomal phospholipid acyl chain remodeling of choline-containing phospholipids, phosphatidylcholine and sphingomyelin, by 50 and 64%, respectively. Phosphatidylcholines 109-128 diazepam binding inhibitor Mus musculus 6-10 9487137-0 1998 Cucumber root lipoxygenase can act on acyl groups in phosphatidylcholine. Phosphatidylcholines 53-72 LOW QUALITY PROTEIN: linoleate 9S-lipoxygenase 6 Cucumis sativus 14-26 9518571-1 1998 The effect of methemoglobin on the structure of model membranes composed of phosphatidylcholine and diphosphatidylglycerol (18 : 1, mol : mol) was studied with the help of pH-indicator dye bromothymol blue. Phosphatidylcholines 76-95 hemoglobin subunit gamma 2 Homo sapiens 14-27 9507109-1 1998 Phosphatidyl-choline (PC) vesicles and normal cell membranes are resistant to hydrolysis by human group II secreted PLA2, an enzyme that can attain high concentrations in extracellular fluids during many inflammatory processes. Phosphatidylcholines 0-20 phospholipase A2 group IIA Homo sapiens 116-120 9507109-1 1998 Phosphatidyl-choline (PC) vesicles and normal cell membranes are resistant to hydrolysis by human group II secreted PLA2, an enzyme that can attain high concentrations in extracellular fluids during many inflammatory processes. Phosphatidylcholines 22-24 phospholipase A2 group IIA Homo sapiens 116-120 9487144-3 1998 We examined involvement of PLD and PKC in the hydrolysis and resynthesis of PtdCho and phosphatidylethanolamine stimulated by beta-TPA, bryostatin (a non-phorbol PKC activator) and oleic acid (18:1n-9) in the four cell lines. Phosphatidylcholines 76-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 9487144-10 1998 Thus, activation of PLD hydrolysis preceding resynthesis is involved in the stimulatory effects of beta-TPA on PtdCho synthesis in some but not all of these neural derived cells. Phosphatidylcholines 111-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-23 9533699-7 1998 The degree of orientational order dropped dramatically in the dipolyunsaturated species compared with the mixed-chain phosphatidylcholines, which contained a polyunsaturated sn-2 chain. Phosphatidylcholines 118-138 solute carrier family 38 member 5 Homo sapiens 174-178 9533708-5 1998 The relatively low sensitivity of halothane quenching of Trp fluorescence to the concentration of phosphatidylcholine and detergent in the PMCA preparation concurs with the quenching resulting from anesthetic binding in the PMCA molecule. Phosphatidylcholines 98-117 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 139-143 9475519-5 1998 The following signal transduction mechanisms, reported to be induced in other systems by IL-1 beta, were investigated in U373 cells: (1) activation of phosphatidylcholine-specific phospholipase C as assayed by incorporation of tritiated choline into cellular phospholipids, (2) production of diacylglycerol, a lipid second messenger, (3) activation of sphingomyelinase, and (4) activation of mitogen-activated protein kinase (MAPK). Phosphatidylcholines 151-170 interleukin 1 beta Homo sapiens 89-98 9569615-1 1998 Porcine pancreatic phospholipase A2 (PLA2) hydrolyses phosphatidylcholine when in the lamellar state as well as in the micellar state. Phosphatidylcholines 54-73 phospholipase A2 group IB Homo sapiens 19-35 9569615-1 1998 Porcine pancreatic phospholipase A2 (PLA2) hydrolyses phosphatidylcholine when in the lamellar state as well as in the micellar state. Phosphatidylcholines 54-73 phospholipase A2 group IB Homo sapiens 37-41 9425156-1 1998 Phospholipase D (PLD) enzymes catalyze the hydrolysis of phosphatidylcholine and are involved in membrane trafficking and cytoskeletal reorganization. Phosphatidylcholines 57-76 phospholipase D Saccharomyces cerevisiae S288C 0-15 9578154-4 1998 Furthermore, pretreatment with PKA activators prevented much of the AIF4(-)-induced loss of [3H]AA from phosphatidylcholine and phosphatidylethanolamine in prelabeled osteoblasts. Phosphatidylcholines 104-123 itchy E3 ubiquitin protein ligase Homo sapiens 68-72 9578155-7 1998 In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine. Phosphatidylcholines 60-79 arginine vasopressin Rattus norvegicus 3-6 9578155-7 1998 In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine. Phosphatidylcholines 60-79 arginine vasopressin Rattus norvegicus 144-147 9430672-1 1998 Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol. Phosphatidylcholines 0-20 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 216-223 9430672-1 1998 Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol. Phosphatidylcholines 0-20 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 225-232 9430672-1 1998 Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol. Phosphatidylcholines 22-25 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 216-223 9430672-1 1998 Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol. Phosphatidylcholines 22-25 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 225-232 9430672-9 1998 The data suggest that different properties of P450SCC in membrane systems including cholesterol binding, membrane integration, and protein exchange are affected by branched PCs and probably by other phospholipids, too, and therefore must be considered in an explanation of the observed high stimulation of activity. Phosphatidylcholines 173-176 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 46-53 9461221-1 1998 The yeast phosphatidylinositol-transfer protein (Sec14) catalyses exchange of phosphatidylinositol and phosphatidylcholine between membrane bilayers in vitro. Phosphatidylcholines 103-122 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 49-54 9442060-2 1998 Specifically, the presence of 1 mol% PtdIns(4,5)P2 in phosphatidylcholine vesicles results in a 20-fold increase in the binding affinity of cPLA2. Phosphatidylcholines 54-73 phospholipase A2 group IVA Homo sapiens 140-145 9448723-2 1998 Treatment of cells with Naja mocambique mocambique phospholipase A2 reduced the pool sizes of phosphatidylcholine and phosphatidylethanolamine compared with controls. Phosphatidylcholines 94-113 phospholipase A2 group IB Rattus norvegicus 51-67 9425156-1 1998 Phospholipase D (PLD) enzymes catalyze the hydrolysis of phosphatidylcholine and are involved in membrane trafficking and cytoskeletal reorganization. Phosphatidylcholines 57-76 phospholipase D Saccharomyces cerevisiae S288C 17-20 9503164-1 1998 We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Phosphatidylcholines 124-143 angiotensinogen Homo sapiens 31-46 9526092-2 1998 LPC is produced as a result of PC hydrolysis by several isoforms of phospholipase A2 (PLA2) and in the reaction mediated by lecithin-cholesterol acyltransferase that transfers the fatty acid residue from PC to cholesterol. Phosphatidylcholines 1-3 phospholipase A2 group IB Homo sapiens 68-84 9419367-1 1998 Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Phosphatidylcholines 120-139 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 61-65 9419367-1 1998 Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Phosphatidylcholines 120-139 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 78-82 9526092-2 1998 LPC is produced as a result of PC hydrolysis by several isoforms of phospholipase A2 (PLA2) and in the reaction mediated by lecithin-cholesterol acyltransferase that transfers the fatty acid residue from PC to cholesterol. Phosphatidylcholines 1-3 phospholipase A2 group IB Homo sapiens 86-90 9503164-1 1998 We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Phosphatidylcholines 124-143 angiotensinogen Homo sapiens 69-74 9503164-1 1998 We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Phosphatidylcholines 124-143 angiotensinogen Homo sapiens 81-95 9503164-1 1998 We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Phosphatidylcholines 124-143 angiotensinogen Homo sapiens 97-103 9407098-4 1997 Unlike recombinant retinol dehydrogenase isozymes, recombinant CRAD was inhibited by 4-methylpyrazole, was not stimulated by ethanol, and did not require phosphatidylcholine for optimal activity. Phosphatidylcholines 154-173 retinol dehydrogenase 16 Mus musculus 63-67 10347747-5 1998 Addition of 0.075% egg phosphatidylcholine (PC) to the four different solubilized rhodopsin samples significantly enhanced light-stimulated GTP hydrolysis by transducin, with initial rates increasing from 0 to 1, 1 to 2, and 5 to 30 pmol of Pi released/min/pmol of rhodopsin, respectively. Phosphatidylcholines 44-46 rhodopsin Homo sapiens 82-91 10347747-5 1998 Addition of 0.075% egg phosphatidylcholine (PC) to the four different solubilized rhodopsin samples significantly enhanced light-stimulated GTP hydrolysis by transducin, with initial rates increasing from 0 to 1, 1 to 2, and 5 to 30 pmol of Pi released/min/pmol of rhodopsin, respectively. Phosphatidylcholines 44-46 rhodopsin Homo sapiens 265-274 9463889-8 1998 Incorporation of phosphatidylethanolamine or phosphatidylserine into phosphatidylcholine vesicles reduced the binding of PDC-109, suggesting that both the density of phosphorylcholine groups and the surface charge determine the interaction of the seminal plasma protein with the surface of the membrane. Phosphatidylcholines 69-88 seminal plasma protein PDC-109 Bos taurus 121-128 19570017-6 1998 Administration of insulin entrapped in positively charged liposomes composed of egg phosphatidylcholine with cholesterol and stearylamine (10: 2:1, in weight ratio) to normal rabbits produced substantial reduction in blood glucose concentration 90-120 min after the instillation of the formulation. Phosphatidylcholines 84-103 insulin Oryctolagus cuniculus 18-25 9463889-9 1998 Electron spin resonance measurements showed that binding of PDC-109 to phosphatidylcholine vesicles caused a rigidification of the membrane. Phosphatidylcholines 71-90 seminal plasma protein PDC-109 Bos taurus 60-67 9436177-2 1998 The present study was performed to examine more fully the developmental biology of the effects of SP-A on phosphatidylcholine (PC) uptake, to determine the effect of SP-A on the cellular location of bound and internalized phospholipid and on the metabolism of internalized phospholipid by morphologically undifferentiated (18-day) and morphologically differentiated (19-day) fetal type II cells. Phosphatidylcholines 106-125 surfactant protein A1 Rattus norvegicus 98-102 9436177-2 1998 The present study was performed to examine more fully the developmental biology of the effects of SP-A on phosphatidylcholine (PC) uptake, to determine the effect of SP-A on the cellular location of bound and internalized phospholipid and on the metabolism of internalized phospholipid by morphologically undifferentiated (18-day) and morphologically differentiated (19-day) fetal type II cells. Phosphatidylcholines 127-129 surfactant protein A1 Rattus norvegicus 98-102 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9752720-8 1998 Similarities in the role of phospholipase D-mediated phosphatidylcholine turnover in the secretory process in yeast and mammals lend further credence to yeast as a model system. Phosphatidylcholines 53-72 phospholipase D Saccharomyces cerevisiae S288C 28-43 9403543-11 1997 Zinc-protoporphyrin type IX, an inhibitor of heme oxygenase, and all 3 antioxidants, which inhibited CO production, also antagonized the TNF-alpha effect on cGMP and phosphatidylcholine synthesis. Phosphatidylcholines 166-185 tumor necrosis factor Homo sapiens 137-146 9405398-3 1997 Incubation of p37 with phosphatidylcholine labeled in the fatty acyl side chains resulted in the production of multiple lipid products that were identified by thin layer chromatography and mass spectrometry as diacylglycerol, free fatty acid, monoacylglycerol, and lysophosphatidylcholine. Phosphatidylcholines 23-42 nucleoporin 37 Homo sapiens 14-17 9393676-10 1997 We present strong evidence for a stimulation of hydrolysis of phosphatidyl-choline by human non-pancreatic sPLA2 in the presence of as little as 1 mol% phosphatidyl-methanol (<40 fold total rate enhancement). Phosphatidylcholines 62-82 phospholipase A2 group X Homo sapiens 107-112 9405440-7 1997 Moreover, this GST-Nedd4-C2 domain was able to mediate Ca2+-dependent interactions with phosphatidylserine, phosphatidylinositol, and phosphatidylcholine liposomes in vitro. Phosphatidylcholines 134-153 NEDD4 E3 ubiquitin protein ligase Canis lupus familiaris 19-24 9359829-15 1997 The binding of Go alpha and mutants translated in vitro to liposomes indicates that Go alpha preferentially binds to neutral phospholipids (phosphatidylcholine). Phosphatidylcholines 140-159 tripartite motif containing 47 Homo sapiens 15-23 9472552-1 1997 We have redesigned cationic liposomes by using a combination of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol to enhance the in vitro and in vivo effectiveness of antisense raf oligodeoxyribonucleotide (ODN). Phosphatidylcholines 102-121 zinc fingers and homeoboxes 2 Homo sapiens 201-204 9371769-2 1997 Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 42-61 phosphatidylethanolamine N-methyltransferase Mus musculus 126-170 9371769-2 1997 Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 42-61 phosphatidylethanolamine N-methyltransferase Mus musculus 172-176 9371769-10 1997 This experiment also demonstrated that the choline moiety derived from PEMT in the liver can be distributed via the plasma throughout the mouse where it is found as phosphatidylcholine, lysophosphatidylcholine, and sphingomyelin. Phosphatidylcholines 165-184 phosphatidylethanolamine N-methyltransferase Mus musculus 71-75 9437199-6 1997 As PAF:acetylhydrolase inactivates PAF and oxidized forms of phosphatidylcholine, we evaluated the relationship of lipoprotein-associated PAF:acetylhydrolase to PAF formation. Phosphatidylcholines 61-80 phospholipase A2 group VII Homo sapiens 3-22 9437199-6 1997 As PAF:acetylhydrolase inactivates PAF and oxidized forms of phosphatidylcholine, we evaluated the relationship of lipoprotein-associated PAF:acetylhydrolase to PAF formation. Phosphatidylcholines 61-80 PCNA clamp associated factor Homo sapiens 3-6 9398170-7 1997 Here is reported the analysis in the other limit, PLA2-catalyzed hydrolysis of zwitterionic micelles of short-chain phosphatidylcholines, at which substrate and products are in rapid exchange. Phosphatidylcholines 116-136 phospholipase A2, major isoenzyme Sus scrofa 50-54 9359829-15 1997 The binding of Go alpha and mutants translated in vitro to liposomes indicates that Go alpha preferentially binds to neutral phospholipids (phosphatidylcholine). Phosphatidylcholines 140-159 tripartite motif containing 47 Homo sapiens 84-92 9428661-0 1997 Characterization and optimization of phospholipase A2 catalyzed synthesis of phosphatidylcholine. Phosphatidylcholines 77-96 phospholipase A2 group IB Homo sapiens 37-53 9360946-7 1997 Our results also indicate that Galpha12QL-Ras stimulation of Na+/H+ exchange involves a D609-sensitive phospholipase and protein kinase C. These studies, for the first time, describe a novel Galpha12-specific signaling pathway involving Ras, phosphatidylcholine hydrolysis, and protein kinase C in the regulation of Na+/H+ exchange. Phosphatidylcholines 242-261 G protein subunit alpha 12 Homo sapiens 31-41 9360946-7 1997 Our results also indicate that Galpha12QL-Ras stimulation of Na+/H+ exchange involves a D609-sensitive phospholipase and protein kinase C. These studies, for the first time, describe a novel Galpha12-specific signaling pathway involving Ras, phosphatidylcholine hydrolysis, and protein kinase C in the regulation of Na+/H+ exchange. Phosphatidylcholines 242-261 G protein subunit alpha 12 Homo sapiens 31-39 9428661-1 1997 The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium. Phosphatidylcholines 66-85 phospholipase A2 group IB Homo sapiens 4-20 9428661-1 1997 The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium. Phosphatidylcholines 66-85 phospholipase A2 group IB Homo sapiens 22-26 9428661-1 1997 The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium. Phosphatidylcholines 87-89 phospholipase A2 group IB Homo sapiens 4-20 9428661-1 1997 The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium. Phosphatidylcholines 87-89 phospholipase A2 group IB Homo sapiens 22-26 9344462-2 1997 In contrast, stimulation of phosphatidylcholine synthesis by PKC activators, known to be mediated by PKC-alpha, is widespread in mammalian cells. Phosphatidylcholines 28-47 protein kinase C alpha Homo sapiens 61-64 9344462-2 1997 In contrast, stimulation of phosphatidylcholine synthesis by PKC activators, known to be mediated by PKC-alpha, is widespread in mammalian cells. Phosphatidylcholines 28-47 protein kinase C alpha Homo sapiens 101-110 9394256-1 1997 Calcitonin-loading was studied in liposomes composed of phosphatidylcholine, cholesterol and stearylamine in relation to the vesicle preparation method. Phosphatidylcholines 56-75 calcitonin related polypeptide alpha Homo sapiens 0-10 9379026-5 1997 We hereby identify two independent mechanisms of CD5-mediated diacylglycerol release by virtue of their different kinetics: 1) an early and transient diacylglycerol increase that results from the activation of a phosphatidylcholine-specific phospholipase C, and 2) a late and sustained increase that requires de novo phospholipid synthesis. Phosphatidylcholines 212-231 CD5 molecule Homo sapiens 49-52 9379026-6 1997 Studies performed on a TCR/CD3-deficient Jurkat cell variant indicate that only the CD5-mediated phosphatidylcholine-specific phospholipase C activation is dependent on TCR/CD3 expression. Phosphatidylcholines 97-116 CD5 molecule Homo sapiens 84-87 9370429-1 1997 In reconstituted high-density lipoproteins, apolipoprotein A-I and phosphatidylcholines combine to form disks in which the amphipathic alpha-helices of apolipoprotein A-1 bind to the edge of a lipid bilayer core, shielding the hydrophic lipid tails from the aqueous environment. Phosphatidylcholines 67-87 apolipoprotein A1 Homo sapiens 152-170 9394256-4 1997 Interactions of calcitonin with the liposomal membranes were evaluated by studying the fixation of radiolabelled calcitonin to the outer surface of empty liposomes, and by preparing calcitonin-loaded LDL-like nanoparticles composed of phosphatidylcholine and cholesteryloleate. Phosphatidylcholines 235-254 calcitonin related polypeptide alpha Homo sapiens 16-26 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidylcholines 61-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-121 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidylcholines 61-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. Phosphatidylcholines 158-177 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9408022-10 1997 Thus, the platelet inhibitory activity of LM-PLA2 was shown to be dependent on the hydrolysis of plasma phospholipids and/or lipoproteins, most probably those rich in phosphatidylcholine. Phosphatidylcholines 167-186 phospholipase A2, group V Mus musculus 45-49 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. Phosphatidylcholines 179-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. Phosphatidylcholines 41-60 phospholipase C beta 1 Homo sapiens 110-119 9334202-9 1997 Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation. Phosphatidylcholines 215-234 phospholipase C beta 1 Homo sapiens 61-106 9334202-9 1997 Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation. Phosphatidylcholines 215-234 phospholipase C beta 1 Homo sapiens 108-114 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. Phosphatidylcholines 41-60 phospholipase C beta 2 Homo sapiens 124-133 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. Phosphatidylcholines 160-179 phospholipase C beta 1 Homo sapiens 110-119 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. Phosphatidylcholines 160-179 phospholipase C beta 2 Homo sapiens 124-133 9312119-0 1997 Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. We investigated the mechanism of interleukin-6 (IL-6) synthesis induced by tumor necrosis factor-alpha (TNF) in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 142-161 tumor necrosis factor Mus musculus 0-27 9312108-4 1997 FRET was observed when Fl-FPR-APC was titrated in the presence of Ca2+ ions with phosphatidylcholine/phosphatidylserine (4:1) vesicles containing the FRET acceptor, octadecylrhodamine (OR). Phosphatidylcholines 81-100 APC regulator of WNT signaling pathway Homo sapiens 30-33 9312119-8 1997 D-609, an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed the TNF-induced diacylglycerol production. Phosphatidylcholines 23-42 tumor necrosis factor Mus musculus 84-87 9312119-13 1997 These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for TNF-induced IL-6 synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells. Phosphatidylcholines 189-208 tumor necrosis factor Mus musculus 130-133 9312119-13 1997 These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for TNF-induced IL-6 synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells. Phosphatidylcholines 189-208 interleukin 6 Mus musculus 148-152 9468621-5 1997 It has been reported in particular that expression of the human MDR3 and mouse mdr2 genes promote translocation of long chain phosphatidylcholine, while expression of the MDR1 gene stimulates the outward motion of phospholipids possessing at least one short chain. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 64-68 9355744-0 1997 Different modes of interaction of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers. Phosphatidylcholines 71-90 surfactant protein B Homo sapiens 63-67 9315860-0 1997 Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Phosphatidylcholines 14-33 lipase C, hepatic type Homo sapiens 37-51 9315860-1 1997 Hepatic lipase (HL) hydrolysis of phosphatidylcholine (PC) was studied in recombinant high-density lipoprotein particles (r-HDL). Phosphatidylcholines 34-53 lipase C, hepatic type Homo sapiens 0-14 9315860-1 1997 Hepatic lipase (HL) hydrolysis of phosphatidylcholine (PC) was studied in recombinant high-density lipoprotein particles (r-HDL). Phosphatidylcholines 55-57 lipase C, hepatic type Homo sapiens 0-14 9315860-10 1997 The hydrolysis of different species of PC [dipalmitoyl (DPPC), dioleoyl(DOPC), palmitoylarachidonoyl (PAPC), and palmitoyloleoyl (POPC)] in r-HDL was also investigated. Phosphatidylcholines 39-41 protocadherin 8 Homo sapiens 102-106 9355744-1 1997 Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution. Phosphatidylcholines 100-119 surfactant protein B Homo sapiens 0-41 9355744-1 1997 Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution. Phosphatidylcholines 100-119 surfactant protein B Homo sapiens 43-47 9355744-1 1997 Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution. Phosphatidylcholines 123-125 surfactant protein B Homo sapiens 0-41 9355744-1 1997 Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution. Phosphatidylcholines 123-125 surfactant protein B Homo sapiens 43-47 9355744-4 1997 Both methods of reconstitution led to the extensive interaction of SP-B with PC bilayers as demonstrated by co-migration during centrifugation, marked protection against proteolysis, change in the fluorescence emission intensity of SP-B, and protection of SP-B tryptophan fluorescence from quenching by acrylamide. Phosphatidylcholines 77-79 surfactant protein B Homo sapiens 67-71 9355744-7 1997 Electron microscopy showed that the injection of SP-B into an aqueous phase containing PC or DPPC vesicles (method A) induced a rapid aggregation of vesicles. Phosphatidylcholines 87-89 surfactant protein B Homo sapiens 49-53 9468621-5 1997 It has been reported in particular that expression of the human MDR3 and mouse mdr2 genes promote translocation of long chain phosphatidylcholine, while expression of the MDR1 gene stimulates the outward motion of phospholipids possessing at least one short chain. Phosphatidylcholines 126-145 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 79-83 9328844-7 1997 D-609, an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed the IL-1-induced diacylglycerol production. Phosphatidylcholines 23-42 interleukin 1 complex Mus musculus 84-88 9328844-9 1997 These results indicate that IL-1 activates PKC via phosphatidylcholine-specific phospholipase C in osteoblast-like cells, and the PKC activation then limits IL-6 synthesis induced by IL-1 itself. Phosphatidylcholines 51-70 interleukin 1 complex Mus musculus 28-32 9328844-9 1997 These results indicate that IL-1 activates PKC via phosphatidylcholine-specific phospholipase C in osteoblast-like cells, and the PKC activation then limits IL-6 synthesis induced by IL-1 itself. Phosphatidylcholines 51-70 interleukin 1 complex Mus musculus 183-187 9321809-0 1997 Complexes of apoA-1 with phosphatidylcholine suppress dysregulation of arterial tone by oxidized LDL. Phosphatidylcholines 25-44 apolipoprotein A1 Homo sapiens 13-19 9307024-1 1997 Activation of phosphatidylcholine-specific phospholipase D(PLD) occurs as part of the complex signal-transduction cascade initiated by agonist stimulation of tyrosine kinase and G-protein-coupled receptors. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-62 9370319-1 1997 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis. Phosphatidylcholines 107-126 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 9370319-1 1997 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis. Phosphatidylcholines 107-126 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 41-44 9370319-1 1997 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis. Phosphatidylcholines 107-126 cut-like homeobox 1 Rattus norvegicus 73-76 9370322-8 1997 Significant differences exist in the behavior of the cholinephosphotransferase activities responsible for the synthesis of PAF and phosphatidylcholine. Phosphatidylcholines 131-150 PCNA clamp associated factor Homo sapiens 123-126 9370325-8 1997 Like the mammalian PEMT gene products, the S. cerevisiae class I enzyme can catalyze all three methylation steps to PC biosynthesis. Phosphatidylcholines 116-118 phosphatidylethanolamine N-methyltransferase Homo sapiens 19-23 9370326-1 1997 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 89-108 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 9370326-1 1997 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 89-108 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 46-50 9370326-7 1997 Deletion of the PEMT gene eliminates all activity in liver that converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 101-120 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 16-20 9370326-10 1997 There is reciprocal regulation of the Kennedy pathway for phosphatidylcholine biosynthesis (via CDP-choline) and phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 58-77 cut-like homeobox 1 Rattus norvegicus 96-99 9370326-10 1997 There is reciprocal regulation of the Kennedy pathway for phosphatidylcholine biosynthesis (via CDP-choline) and phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 58-77 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 113-157 9326304-3 1997 The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40). Phosphatidylcholines 95-114 amyloid beta precursor protein Homo sapiens 134-140 9326304-3 1997 The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40). Phosphatidylcholines 116-118 amyloid beta precursor protein Homo sapiens 134-140 9326304-3 1997 The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40). Phosphatidylcholines 116-118 amyloid beta precursor protein Homo sapiens 204-210 9299527-1 1997 Synthetic melittin inhibited the enzymatic activity of secretory phospholipase A2 (PLA2) from various sources, including bee and snake venoms, bovine pancreas, and synovial fluid from rheumatoid arthritis patients, irrespective of substrate (e.g., [14C]-phosphatidylcholine or phosphatidylethanolamine vesicles and [3H]-oleic acid-labeled E.coli). Phosphatidylcholines 254-273 phospholipase A2 group IIA Homo sapiens 83-87 9278459-3 1997 In the present study, we show that MAP1B purified from young rat brain can bind to acidic phospholipids, such as phosphatidylserine, but not to a neutral phospholipid, phosphatidylcholine. Phosphatidylcholines 168-187 microtubule-associated protein 1B Rattus norvegicus 35-40 9281306-0 1997 Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts. Phosphatidylcholines 51-70 coagulation factor II Mus musculus 0-8 9281306-0 1997 Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts. Phosphatidylcholines 51-70 interleukin 6 Mus musculus 19-32 9307942-0 1997 Preparation of Schiff base adducts of phosphatidylcholine core aldehydes and aminophospholipids, amino acids, and myoglobin. Phosphatidylcholines 38-57 myoglobin Homo sapiens 114-123 9281306-1 1997 We previously reported that thrombin stimulates Ca2+ influx and activates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 74-93 coagulation factor II Mus musculus 28-36 9294443-11 1997 In yeast, phosphatidylcholine (PC) biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol. Phosphatidylcholines 10-29 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 133-137 9294443-11 1997 In yeast, phosphatidylcholine (PC) biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol. Phosphatidylcholines 31-33 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 133-137 9254602-0 1997 Lateral packing of the pancreatic lipase cofactor, colipase, with phosphatidylcholine and substrates. Phosphatidylcholines 66-85 colipase Homo sapiens 51-59 9266766-6 1997 An ensuing generation of lysoPC and arachidonic acid, which paralleled the occurrence of exocytosis, revealed that the newly synthesized PC was hydrolyzed by phospholipase A2. Phosphatidylcholines 29-31 phospholipase A2 group IB Homo sapiens 158-174 9323586-4 1997 The SM content of microsomes from NADe-fed rats was about one-third lower than for the control, and phosphatidylcholine (PC) was reduced by < 10%; there was also a small decrease in PC, but not SM, in plasma membranes. Phosphatidylcholines 121-123 brain expressed X-linked 3 Rattus norvegicus 34-38 9305796-6 1997 We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG). Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-106 9305796-6 1997 We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG). Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 9254602-6 1997 Phosphatidylcholine, diacylglycerols, and free fatty acid remain in the monolayer phase up to </=25 lipid chain:colipase ratios. Phosphatidylcholines 0-19 colipase Homo sapiens 115-123 9254602-11 1997 Phosphatidylcholine also remains in the interface at lipid chain:colipase ratios >3 but shows little additional interaction with colipase. Phosphatidylcholines 0-19 colipase Homo sapiens 65-73 9252414-7 1997 Misregulation of the INO1 gene has been observed in many strains with altered phospholipid metabolism, and the relationship between phosphatidylcholine turnover and regulation of INO1 and other co-regulated genes of phospholipid biosynthesis is discussed. Phosphatidylcholines 132-151 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 179-183 9295162-1 1997 Phosphatidylcholine is the major phospholipid in mammalian tissues and the biosynthesis of phosphatidylcholine in H9c2 cells was previously shown to be stimulated by angiotensin II. Phosphatidylcholines 0-19 angiotensinogen Rattus norvegicus 166-180 9295162-1 1997 Phosphatidylcholine is the major phospholipid in mammalian tissues and the biosynthesis of phosphatidylcholine in H9c2 cells was previously shown to be stimulated by angiotensin II. Phosphatidylcholines 91-110 angiotensinogen Rattus norvegicus 166-180 9295162-2 1997 In this study, we used the potent AT1 receptor antagonist, losartan, to determine if the angiotensin II-mediated stimulation of phosphatidylcholine biosynthesis was mediated by AT1 receptors. Phosphatidylcholines 128-147 angiotensinogen Rattus norvegicus 89-103 9295162-8 1997 High concentrations of losartan caused a translocation of CTP:phosphocholine cytidylyltransferase from the cytosolic (inactive) to the membrane (active) fraction likely as a compensatory mechanism for the losartan-mediated reduction in new phosphatidylcholine biosynthesis. Phosphatidylcholines 240-259 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 58-97 9295162-10 1997 The results suggest that angiotensin II stimulates phosphatidylcholine biosynthesis independent of AT1- and AT2-receptor activation and losartan inhibits phosphatidylcholine biosynthesis by reducing choline uptake in H9c2 cells. Phosphatidylcholines 51-70 angiotensinogen Rattus norvegicus 25-39 9252414-0 1997 Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation. Phosphatidylcholines 39-58 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 77-83 9360016-4 1997 The activity of delta 5-desaturase was higher in the upper than in the lower portions of the villus, and was greater in P than in S. The activity of delta 9- and delta 6-desaturases did not vary along the villus or with changes in dietary S or P. The two predominant EMM phospholipids were phosphatidylcholine and phosphatidylethanolamine, and these did not vary along the villus or with changes in diet. Phosphatidylcholines 290-309 fatty acid desaturase 1 Rattus norvegicus 16-34 9252414-0 1997 Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation. Phosphatidylcholines 39-58 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 121-125 9252414-1 1997 In yeast, mutations in the CDP-choline pathway for phosphatidylcholine biosynthesis permit the cell to grow even when the SEC14 gene is completely deleted (Cleves, A., McGee, T., Whitters, E., Champion, K., Aitken, J., Dowhan, W., Goebl, M., and Bankaitis, V. (1991) Cell 64, 789-800). Phosphatidylcholines 51-70 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 122-127 9252414-2 1997 We report that strains carrying mutations in the CDP-choline pathway, such as cki1, exhibit a choline excretion phenotype due to production of choline during normal turnover of phosphatidylcholine. Phosphatidylcholines 177-196 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 78-82 9252414-4 1997 We show that the increased choline excretion in sec14(ts) cki1 cells is due to increased turnover of phosphatidylcholine via a mechanism consistent with phospholipase D-mediated turnover. Phosphatidylcholines 101-120 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 48-53 9252414-4 1997 We show that the increased choline excretion in sec14(ts) cki1 cells is due to increased turnover of phosphatidylcholine via a mechanism consistent with phospholipase D-mediated turnover. Phosphatidylcholines 101-120 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 58-62 9252414-5 1997 We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated. Phosphatidylcholines 37-56 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 69-74 9252414-5 1997 We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated. Phosphatidylcholines 37-56 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 79-83 9252414-5 1997 We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated. Phosphatidylcholines 37-56 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 175-181 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Phosphatidylcholines 3-22 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 45-50 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Phosphatidylcholines 3-22 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 55-59 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Phosphatidylcholines 3-22 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 110-114 9267689-1 1997 We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 59-78 endothelin 1 Mus musculus 28-40 9267689-1 1997 We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 59-78 endothelin 1 Mus musculus 42-46 9267689-7 1997 The results strongly suggest that ETA receptor mediates the three intracellular signaling pathways of ET-1: (1) phosphoinositide hydrolysis by phospholipase C; (2) phosphatidylcholine hydrolysis by phospholipase D; (3) arachidonic acid release in osteoblast-like cells. Phosphatidylcholines 164-183 endothelin 1 Mus musculus 102-106 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 59-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 59-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9256237-2 1997 The nociceptin receptor-mediated MAPK activation was partially blocked by down-regulation or inhibition of protein kinase C, and suppressed by pretreatment with a phosphatidylcholine-specific phospholipase C inhibitor, D609. Phosphatidylcholines 163-182 nociceptin receptor Cricetulus griseus 4-23 9260748-7 1997 The phospholipid asymmetry of NF1T plasma membrane followed the general features of phospholipid asymmetry in eukaryotic cells: sphingomyelin and phosphatidylcholine were preferentially located in the outer leaflet (90% and 89%, respectively) while the aminophospholipids phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol were in the inner half of the membrane (85%, 96%, and 69%, respectively). Phosphatidylcholines 146-165 neurofibromin 1 Homo sapiens 30-33 9211897-3 1997 HDL and dimyristoyl phosphatidylcholine binding assays using the variant apoA-I forms have shown that replacement of specific carboxyl-terminal hydrophobic residues Leu222, Phe225, and Phe229 with lysines, as well as replacement of Leu211, Leu214, Leu218, and Leu219 with valines, diminished the ability of apoA-I to bind to HDL and to lyse dimyristoyl phosphatidylcholine liposomes. Phosphatidylcholines 20-39 apolipoprotein A1 Homo sapiens 73-79 9201967-4 1997 The demonstration that Class II P-gps function as phosphatidylcholine (PC) translocators raise the possibility that other ABC transporters may also interact with physiological lipids. Phosphatidylcholines 50-69 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 122-125 9224204-6 1997 Through the use of specific inhibitors, we demonstrate that phosphatidylcholine (PC)-specific phospholipase C (PLC) and protein kinase C (PKC) are involved in mediating the elastin message stabilization. Phosphatidylcholines 60-79 elastin Homo sapiens 173-180 9224204-6 1997 Through the use of specific inhibitors, we demonstrate that phosphatidylcholine (PC)-specific phospholipase C (PLC) and protein kinase C (PKC) are involved in mediating the elastin message stabilization. Phosphatidylcholines 81-83 elastin Homo sapiens 173-180 9201966-2 1997 The interactions of recombinant SP-D with monolayers of phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylinositol (PI) spread at the air-water interface have been characterized. Phosphatidylcholines 56-75 surfactant protein D Rattus norvegicus 32-36 9201967-4 1997 The demonstration that Class II P-gps function as phosphatidylcholine (PC) translocators raise the possibility that other ABC transporters may also interact with physiological lipids. Phosphatidylcholines 71-73 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 122-125 9201966-2 1997 The interactions of recombinant SP-D with monolayers of phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylinositol (PI) spread at the air-water interface have been characterized. Phosphatidylcholines 77-79 surfactant protein D Rattus norvegicus 32-36 9201967-5 1997 We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6. Phosphatidylcholines 56-58 phosphoglycolate phosphatase Mus musculus 127-131 9224650-7 1997 These results suggest that the production of DAG from phosphatidylcholine was upstream of NFkappaB activation in response to a CD14-mediated LPS stimulus. Phosphatidylcholines 54-73 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 90-98 9224650-7 1997 These results suggest that the production of DAG from phosphatidylcholine was upstream of NFkappaB activation in response to a CD14-mediated LPS stimulus. Phosphatidylcholines 54-73 CD14 antigen Mus musculus 127-131 9201967-5 1997 We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6. Phosphatidylcholines 56-58 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 190-193 9201967-5 1997 We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6. Phosphatidylcholines 56-58 ATP binding cassette subfamily C member 3 Homo sapiens 207-210 9201967-5 1997 We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6. Phosphatidylcholines 56-58 ATP-binding cassette a-factor transporter STE6 Saccharomyces cerevisiae S288C 223-227 9201967-11 1997 These results suggest that the group of cytotoxic synthetic PC analogs studied reveal possible structural and functional aspects common to the ABC transporters tested. Phosphatidylcholines 60-62 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 143-146 9201967-12 1997 Furthermore, the studies with BSA and MAMO suggest that the mechanism of transport of ET-18-OCH3 by these ABC transporters may be related to the flippase mechanism of PC transport by Mdr2. Phosphatidylcholines 167-169 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 106-109 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 280-299 phospholipase A2 group VII Homo sapiens 141-183 9298595-8 1997 These results suggest that 2H2O behaves similarly to previously reported inhibitors of Na+/H+ exchange, disclosing also a novel role for PtdCho metabolism in the regulation on hepatic pHi. Phosphatidylcholines 137-143 glucose-6-phosphate isomerase 1 Mus musculus 184-187 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 280-299 phospholipase A2 group VII Homo sapiens 185-191 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 301-303 phospholipase A2 group VII Homo sapiens 141-183 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 301-303 phospholipase A2 group VII Homo sapiens 185-191 9185174-7 1997 Bat PKC, however, made use of other phospholipids and showed relative activities of 100:81:33:42 for euthermic PKC and 100:91:45:35 for hibernator PKC with phosphatidylserine, phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine (each at 50 microM), respectively. Phosphatidylcholines 198-217 protein kinase C, gamma Rattus norvegicus 4-7 9237867-3 1997 The AA liberated by ET-1 appears to derive mainly from the phosphoinositides and phosphatidylcholine. Phosphatidylcholines 81-100 endothelin 1 Homo sapiens 20-24 9211348-6 1997 Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P < 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P < 0.001). Phosphatidylcholines 155-175 cytosolic phospholipase A2 Oryctolagus cuniculus 72-77 9211348-6 1997 Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P < 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P < 0.001). Phosphatidylcholines 155-175 phospholipase A2 Oryctolagus cuniculus 66-70 9220345-1 1997 The physiological activator of protein kinase C (PKC), diacylglycerol, is formed by hydrolysis of phosphoinositides (PI) by phospholipase C (PLC) or phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 149-168 protein kinase C, delta Rattus norvegicus 49-52 9227534-6 1997 Immunohistochemical localization of P-selectin and intercellular adhesion molecule-1 (ICAM-1) expression on mesenteric venules was significantly increased after exposure to LPC compared with mesenteries superfused with phosphatidylcholine (P < 0.001). Phosphatidylcholines 219-238 selectin P Rattus norvegicus 36-46 9227534-6 1997 Immunohistochemical localization of P-selectin and intercellular adhesion molecule-1 (ICAM-1) expression on mesenteric venules was significantly increased after exposure to LPC compared with mesenteries superfused with phosphatidylcholine (P < 0.001). Phosphatidylcholines 219-238 intercellular adhesion molecule 1 Rattus norvegicus 86-92 9437256-3 1997 The antioxidant effect of NAF was about 3 times less potent than that of alpha-tocopherol (alpha-TOC) in phosphatidylcholine liposomes, and NAF was about 2-4 times more efficient to decrease peroxidation of LDL than alpha-TOC. Phosphatidylcholines 105-124 C-X-C motif chemokine ligand 8 Homo sapiens 26-29 9188469-9 1997 hGX sPLA2 prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. Phosphatidylcholines 47-66 phospholipase A2 group X Homo sapiens 4-9 9200687-1 1997 The specific binding of hen egg white avidin to phosphatidylcholine lipid membranes containing spin-labeled N-biotinylphosphatidylethanolamines (biotin-PESLs) was investigated by using ESR spectroscopy. Phosphatidylcholines 48-67 spindlin 1 Homo sapiens 95-99 9219902-6 1997 Whereas venom PLA2 was cytolytic in the presence of either phosphatidylcholine or phosphatidylethanolamine (PE), rh-sPLA2 caused cell death only in the presence of PE. Phosphatidylcholines 59-78 phospholipase A2 group IIA Homo sapiens 14-18 9194753-6 1997 Injection of a neutralizing CETP monoclonal antibody (MAb) (TP2) into natural flanking region CETP Tg mice resulted in an increase in plasma free cholesterol (FC) concentration, FC/CE ratio, FC/phosphatidylcholine ratio, and hepatic CETP mRNA. Phosphatidylcholines 194-213 cholesteryl ester transfer protein Homo sapiens 28-32 9194753-6 1997 Injection of a neutralizing CETP monoclonal antibody (MAb) (TP2) into natural flanking region CETP Tg mice resulted in an increase in plasma free cholesterol (FC) concentration, FC/CE ratio, FC/phosphatidylcholine ratio, and hepatic CETP mRNA. Phosphatidylcholines 194-213 transition protein 2 Mus musculus 60-63 9194753-7 1997 In hamsters, CETP inhibition also resulted in an increase in plasma FC/phosphatidylcholine ratio and increased CETP mRNA in adipose tissue. Phosphatidylcholines 71-90 cholesteryl ester transfer protein Homo sapiens 13-17 9178697-6 1997 Increased biliary immunoreactive PLA2-II levels in multiple cholesterol stones were associated with a concomitant increase in the lysophosphatidylcholine to phosphatidylcholine ratio; free arachidonate, protein, and hexosamine concentrations; and gallbladder bile viscosity. Phosphatidylcholines 134-153 phospholipase A2 group IIA Homo sapiens 33-37 9215538-1 1997 Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system. Phosphatidylcholines 151-170 lecithin-cholesterol acyltransferase Homo sapiens 49-85 9215538-1 1997 Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system. Phosphatidylcholines 151-170 lecithin-cholesterol acyltransferase Homo sapiens 87-91 9215538-1 1997 Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system. Phosphatidylcholines 151-170 apolipoprotein A1 Homo sapiens 97-115 9215538-1 1997 Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system. Phosphatidylcholines 151-170 apolipoprotein A1 Homo sapiens 117-123 10024494-1 1997 Phospholipase D catalyses the hydrolysis of phosphatidylcholine to generate phosphatidate. Phosphatidylcholines 44-63 phospholipase D Saccharomyces cerevisiae S288C 0-15 9223659-1 1997 In a previous study, we have reported that thrombin stimulates phosphatidylcholine hydrolysis by phospholipase (PL) D, but has little effect on phosphoinositide hydrolysis by PLC in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 63-82 coagulation factor II Mus musculus 43-51 9148929-3 1997 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells. Phosphatidylcholines 103-105 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 9153219-1 1997 Lysophosphatidylcholine (lyso-PC), a natural lipid generated through the action of phospholipase A2 on membrane phosphatidylcholine, has been implicated in atherogenesis and the inflammatory process. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 83-99 9148929-3 1997 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells. Phosphatidylcholines 103-105 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-2 9148961-0 1997 Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells. Phosphatidylcholines 0-19 carboxyl ester lipase Homo sapiens 47-78 9148929-3 1997 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells. Phosphatidylcholines 178-180 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 9148961-0 1997 Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 84-100 9148929-3 1997 CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells. Phosphatidylcholines 178-180 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-2 9148961-8 1997 We demonstrate that both phospholipase A2 and cholesterol esterase increase cholesterol uptake by hydrolyzing the phosphatidylcholine that is used to prepare the cholesterol-containing micelles. Phosphatidylcholines 114-133 phospholipase A2 group IB Homo sapiens 25-41 9187296-7 1997 Enhanced biosynthesis of phosphatidylcholine after partial hepatectomy was due to increased activity and amount of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 25-44 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 115-154 9148961-8 1997 We demonstrate that both phospholipase A2 and cholesterol esterase increase cholesterol uptake by hydrolyzing the phosphatidylcholine that is used to prepare the cholesterol-containing micelles. Phosphatidylcholines 114-133 carboxyl ester lipase Homo sapiens 46-66 9153408-0 1997 Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. Phosphatidylcholines 0-19 ATP binding cassette subfamily B member 1 Homo sapiens 83-87 9176249-2 1997 In fetal lung, glucocorticoids increase synthesis of phosphatidylcholine, the principal lipid component of surfactant, and there is evidence that this effect is mediated by increased expression of the FAS gene. Phosphatidylcholines 53-72 fatty acid synthase Rattus norvegicus 201-204 9115289-6 1997 Phosphatidylcholine/cholesterol liposomes containing purified Thy-1 in their membranes were much more sensitive to aerolysin than protein-free liposomes. Phosphatidylcholines 0-19 Thy-1 cell surface antigen Homo sapiens 62-67 9155155-4 1997 The other subclass, MDR3, which does not show the multidrug resistance, translocates phosphatidyl choline selectively into the outer leaflet of the liver canalicular membrane, and may protect the liver from the detergent effect of bile acids. Phosphatidylcholines 85-105 ATP binding cassette subfamily B member 4 Homo sapiens 20-24 9149106-1 1997 Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation. Phosphatidylcholines 4-23 protein kinase C iota Homo sapiens 276-279 9149106-1 1997 Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation. Phosphatidylcholines 29-35 protein kinase C iota Homo sapiens 276-279 9101422-5 1997 Experiments with [3H]lyso PAF indicate that human mononuclear bone marrow cells and marrow stromal cells actively acylate lyso PAF into a 1-alkyl analogue of phosphatidylcholine. Phosphatidylcholines 158-177 PCNA clamp associated factor Homo sapiens 26-29 9101422-5 1997 Experiments with [3H]lyso PAF indicate that human mononuclear bone marrow cells and marrow stromal cells actively acylate lyso PAF into a 1-alkyl analogue of phosphatidylcholine. Phosphatidylcholines 158-177 PCNA clamp associated factor Homo sapiens 127-130 9218127-7 1997 The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC. Phosphatidylcholines 157-159 heparan sulfate proteoglycan 2 Homo sapiens 121-124 9218127-7 1997 The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC. Phosphatidylcholines 157-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 9109516-7 1997 Stretch-induced increases in PC biosynthesis and PCT activity correlated well (r = 0.983) and were significantly reduced by pretreating (1 h) the cells with an iron chelator (deferoxamine) or scavengers of reactive oxygen species such as superoxide dismutase and catalase. Phosphatidylcholines 29-31 catalase Rattus norvegicus 263-271 9139830-2 1997 This requirement can be relieved by inactivation of the cytosine 5"-diphosphate (CDP)-choline pathway for phosphatidylcholine biosynthesis, indicating that Sec14p is an essential component of a regulatory pathway linking phospholipid metabolism with vesicle trafficking (the Sec14p pathway). Phosphatidylcholines 106-125 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 156-162 9205947-6 1997 RESULTS: Type II NOS production by both human and mouse cells could be prevented by the addition of the specific inhibitor of phosphatidylcholine-specific phospholipase C, D609, and of agents that interfere with the activation of NF-kappa B. Phosphatidylcholines 126-145 nitric oxide synthase 2 Homo sapiens 9-20 9103463-3 1997 In this work, we show that the phospholipid component of HDL, phosphatidylcholine (PC), is both necessary and sufficient for LBP-catalyzed neutralization of LPS through either mechanism. Phosphatidylcholines 62-81 lipopolysaccharide binding protein Homo sapiens 125-128 9111071-0 1997 Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Phosphatidylcholines 22-41 mitogen-activated protein kinase 1 Mus musculus 255-292 9111071-5 1997 Reversion of v-Ras- or PC-PLC-induced transformation by expression of dominant negative lambdaPKC abolished the nuclear ERK activation suggesting lambdaPKC as a novel, direct or indirect, activator of mitogen-activated protein kinase/ERK kinase in response to activated Ras or elevated levels of phosphatidylcholine-derived diacylglycerol. Phosphatidylcholines 296-315 mitogen-activated protein kinase 1 Mus musculus 120-123 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 171-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 171-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 192-198 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 192-198 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 9103463-3 1997 In this work, we show that the phospholipid component of HDL, phosphatidylcholine (PC), is both necessary and sufficient for LBP-catalyzed neutralization of LPS through either mechanism. Phosphatidylcholines 83-85 lipopolysaccharide binding protein Homo sapiens 125-128 9065474-2 1997 Synthesis of phosphatidylcholine and triacylglycerols was reconstituted in freshly isolated microsomes by the addition of precursors of these glycerolipids (acylcoenzyme A, glycerol 3-phosphate, and CDP-choline) before, during, or after translation. Phosphatidylcholines 13-32 cut like homeobox 1 Canis lupus familiaris 199-202 9100011-0 1997 Pulmonary surfactant protein SP-B interacts similarly with dipalmitoylphosphatidylglycerol and dipalmitoylphosphatidylcholine in phosphatidylcholine/phosphatidylglycerol mixtures. Phosphatidylcholines 106-125 surfactant protein B Homo sapiens 29-33 9109447-5 1997 LPL induction of lipoprotein uptake significantly increased the rates of choline incorporation into phosphatidylcholine (PC) and disaturated PC, and these effects were associated with a three-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase. Phosphatidylcholines 100-119 lipoprotein lipase Rattus norvegicus 0-3 9109447-5 1997 LPL induction of lipoprotein uptake significantly increased the rates of choline incorporation into phosphatidylcholine (PC) and disaturated PC, and these effects were associated with a three-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase. Phosphatidylcholines 121-123 lipoprotein lipase Rattus norvegicus 0-3 9115999-4 1997 Slowing of cPLA2-catalyzed hydrolysis of substrates present in phosphatidylmethanol and phosphatidylcholine vesicles is primarily due to apparent inactivation rather than to substrate depletion. Phosphatidylcholines 88-107 phospholipase A2 group IVA Homo sapiens 11-16 9132017-9 1997 In contrast to spontaneous transfer, PLTP mediates the accumulation of PC in small rHDL particles. Phosphatidylcholines 71-73 phospholipid transfer protein Homo sapiens 37-41 9175129-1 1997 The role of phosphatidylcholine (PC) and phosphatidylinositol (PI) specific phospholipase C (PLC) enzymes in the release of immunoreactive arginine vasopressin (ir-AVP) from rat hypothalami in vitro was examined. Phosphatidylcholines 12-31 arginine vasopressin Rattus norvegicus 148-159 9054384-0 1997 Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins. Phosphatidylcholines 60-79 phospholipid transfer protein Homo sapiens 0-29 9054396-5 1997 This new PLD activity was partially stimulated by phosphatidylinositol 4-phosphate, but not by other phospholipids, including phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, or phosphatidylcholine. Phosphatidylcholines 212-231 phospholipase D alpha 1 Arabidopsis thaliana 9-12 9054384-6 1997 Determination of the label profiles showed that cholesterol as well as phosphatidylcholine were transferred from the vesicles to PLTP. Phosphatidylcholines 71-90 phospholipid transfer protein Homo sapiens 129-133 9054384-0 1997 Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins. Phosphatidylcholines 106-125 phospholipid transfer protein Homo sapiens 0-29 9054384-7 1997 The reversible nature of the binding was shown by the transfer of labeled cholesterol and phosphatidylcholine bound to PLTP to the acceptor vesicles or low density lipoprotein. Phosphatidylcholines 90-109 phospholipid transfer protein Homo sapiens 119-123 9054384-1 1997 Phospholipid transfer protein (PLTP) purified from human plasma was found to enhance the transfer of cholesterol from single bilayer vesicles containing phosphatidylcholine and cholesterol to high density lipoprotein-3. Phosphatidylcholines 153-172 phospholipid transfer protein Homo sapiens 0-29 9054384-8 1997 Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol. Phosphatidylcholines 59-78 phospholipid transfer protein Homo sapiens 91-95 9054384-8 1997 Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol. Phosphatidylcholines 162-181 phospholipid transfer protein Homo sapiens 34-38 9054384-1 1997 Phospholipid transfer protein (PLTP) purified from human plasma was found to enhance the transfer of cholesterol from single bilayer vesicles containing phosphatidylcholine and cholesterol to high density lipoprotein-3. Phosphatidylcholines 153-172 phospholipid transfer protein Homo sapiens 31-35 9054384-8 1997 Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol. Phosphatidylcholines 162-181 phospholipid transfer protein Homo sapiens 91-95 9054384-5 1997 To determine the binding of cholesterol and phosphatidylcholine to PLTP, the mixtures of PLTP and the vesicles containing 3H-labeled phosphatidylcholine and 14C-labeled cholesterol were incubated and subjected to sucrose density gradient centrifugation. Phosphatidylcholines 44-63 phospholipid transfer protein Homo sapiens 67-71 9054384-9 1997 The phosphatidylcholine binding affinity and capacity were greater when PLTP was incubated with phosphatidylcholine vesicles without cholesterol. Phosphatidylcholines 4-23 phospholipid transfer protein Homo sapiens 72-76 9054384-9 1997 The phosphatidylcholine binding affinity and capacity were greater when PLTP was incubated with phosphatidylcholine vesicles without cholesterol. Phosphatidylcholines 96-115 phospholipid transfer protein Homo sapiens 72-76 9054396-4 1997 However, both the antisense transgenic and wild-type plants showed comparable PLD activity in the presence of submicromolar concentrations of calcium and phosphatidylinositol 4, 5-bisphosphate using phosphatidylcholine as a substrate. Phosphatidylcholines 199-218 phospholipase D alpha 1 Arabidopsis thaliana 78-81 9117002-2 1997 We investigated whether human recombinant KGF (rKGF) could increase alveolar and lung-tissue saturated phosphatidyl-choline (Sat PC) in preterm rabbits delivered at 28.5 d gestation. Phosphatidylcholines 103-123 fibroblast growth factor 7 Rattus norvegicus 47-51 9045633-4 1997 Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa. Phosphatidylcholines 216-235 thrombomodulin Homo sapiens 78-92 9045633-4 1997 Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa. Phosphatidylcholines 216-235 thrombomodulin Homo sapiens 94-96 9117002-2 1997 We investigated whether human recombinant KGF (rKGF) could increase alveolar and lung-tissue saturated phosphatidyl-choline (Sat PC) in preterm rabbits delivered at 28.5 d gestation. Phosphatidylcholines 103-123 fibroblast growth factor 7 Homo sapiens 42-45 9057095-8 1997 These results strongly suggest that phosphatidylcholine hydrolysis by phospholipase D is involved in the arachidonic acid release induced by ET-1 in osteoblast-like cells. Phosphatidylcholines 36-55 endothelin 1 Mus musculus 141-145 9084877-6 1997 We also performed inhibition assays of carbohydrate binding and of phosphatidylserine/phosphatidylcholine liposome binding of recombinant p33/41 (annexin IV) with anti-p33/41 monoclonal antibodies (AS11 and AS17). Phosphatidylcholines 86-105 annexin A4 Bos taurus 146-156 9101426-13 1997 269: 2852-2862), we conclude that only apoB-truncations that assemble a neutral lipid core require phosphatidylcholine synthesis. Phosphatidylcholines 99-118 apolipoprotein B Rattus norvegicus 39-43 9066784-0 1997 Phosphatidylinositol- and phosphatidylcholine-dependent phospholipases C are involved in the mechanism of action of atrial natriuretic factor in cultured rat aortic smooth muscle cells. Phosphatidylcholines 26-45 natriuretic peptide A Rattus norvegicus 116-141 9066784-2 1997 Our results indicate that ANF initially stimulates a phosphatidylinositol-dependent phospholipase C (PI-PLC) with a significant increase of DAG, enriched in arachidonate, and inositol trisphosphate (IP3) and then a phosphatidylcholine-dependent phospholipase C (PC-PLC) with formation of DAG, enriched in myristate, and phosphocholine (Pcho). Phosphatidylcholines 215-234 natriuretic peptide A Rattus norvegicus 26-29 9138891-1 1997 Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce a specific vesicle aggregation in lipid-vesicle reconstituted systems. Phosphatidylcholines 0-20 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 195-213 9101426-14 1997 Other experiments established that the requirement of phosphatidylcholine for apoB secretion is related to the presence of neutral lipid associated with a truncation, rather than the length of apoB. Phosphatidylcholines 54-73 apolipoprotein B Rattus norvegicus 78-82 9101429-7 1997 Stimulation of cells with interleukin-1 beta enhanced the synthesis of both fluorescent PI (approximately 88%) and PC (approximately 250%) compared to non-stimulated cells, but with less incorporation of 32Pi into fluorescent PI. Phosphatidylcholines 115-117 interleukin 1 beta Homo sapiens 26-44 9138891-1 1997 Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce a specific vesicle aggregation in lipid-vesicle reconstituted systems. Phosphatidylcholines 0-20 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 206-213 9138891-3 1997 Because branched phosphatidylcholines containing 2-alkyl substituted fatty acid chains belong to a new class of phosphatidylcholines forming inverted nonbilayer phases the results indicate that nonbilayer lipids might play an important role in the function of mitochondrial P450SCC. Phosphatidylcholines 17-37 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 274-281 9138891-3 1997 Because branched phosphatidylcholines containing 2-alkyl substituted fatty acid chains belong to a new class of phosphatidylcholines forming inverted nonbilayer phases the results indicate that nonbilayer lipids might play an important role in the function of mitochondrial P450SCC. Phosphatidylcholines 112-132 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 274-281 9048565-10 1997 Apolipoprotein A-IV strongly stimulated the hydrolysis of phosphatidylcholine and phosphatidylethanolamine in both lipoproteins, while the hydrolysis of triglycerides was completely inhibited. Phosphatidylcholines 58-77 apolipoprotein A4 Homo sapiens 0-19 9047367-2 1997 A three-dimensional (3D) reconstruction of BBMI was made from images of negatively stained, two-dimensional (2D) crystals grown on lipid monolayers formed from mixtures of phosphatidylserine and phosphatidylcholine. Phosphatidylcholines 195-214 myosin IA Homo sapiens 43-47 9048565-4 1997 The effect of apolipoprotein A-IV on hepatic lipase-catalyzed dolichol acylation and phospholipid hydrolysis was studied in model membranes and compared with the effects of apolipoprotein A-I and E. Apolipoprotein A-IV strongly stimulated dolichol acylation and phosphatidylethanolamine hydrolysis but partly inhibited phosphatidylcholine hydrolysis. Phosphatidylcholines 319-338 lipase C, hepatic type Homo sapiens 37-51 9020094-8 1997 Here we show that incubation of serum-starved CHO cells with D609, a purported inhibitor of phosphatidylcholine-specific phospholipase C, also results in a mobility shift of Raf-1 that is due to hyperphosphorylation on sites identical to those observed following mitogen stimulation. Phosphatidylcholines 92-111 RAF proto-oncogene serine/threonine-protein kinase Cricetulus griseus 174-179 9116917-0 1997 Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells. Phosphatidylcholines 209-228 angiotensinogen Rattus norvegicus 13-27 9070263-3 1997 Therefore, we investigated whether mdr2 P-glycoprotein is involved in the transport of a water-soluble short chain phosphatidylcholine analogue L-alpha-dibutyroyl-PC (diC4PC) induced by expression of liver mRNA in Xenopus laevis oocytes. Phosphatidylcholines 115-134 ATP binding cassette subfamily B member 4 Rattus norvegicus 35-39 9070263-7 1997 The present data prove the existence of a specific mRNA for a non-mdr2-coded cell membrane PC carrier in mouse, rat, and human liver which exhibits similar transport affinity for diC4PC as the PC carrier in rat liver canalicular membranes. Phosphatidylcholines 91-93 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 66-70 9017186-6 1997 As shown by CD experiments, helical conformer was induced for NG(28-43) in vesicular solution containing phosphatidyl serine (PS), whereas no helix can be discerned for the peptide in phosphatidyl choline (PC)-containing vesicular solution. Phosphatidylcholines 206-208 neurogranin Homo sapiens 62-64 9116917-9 1997 These results strongly suggest that the AA metabolite release induced by Ang II is mediated, at least in part, through phosphatidylcholine hydrolysis by phospholipase D activation in aortic smooth muscle cells. Phosphatidylcholines 119-138 angiotensinogen Rattus norvegicus 73-79 9124287-2 1997 PLA2 activity was measured in isolated membrane and cytosol fractions with (16:0,[3H]18:1) plasmenylcholine and (16:0,[3H]18:1) phosphatidylcholine in the absence and presence of Ca2+. Phosphatidylcholines 128-147 phospholipase A2 group IB Rattus norvegicus 0-4 9124287-4 1997 In the presence of Ca2+ with phosphatidylcholine, IL-1beta had no effect on membrane-associated PLA2 but decreased cytosolic PLA2 activity. Phosphatidylcholines 29-48 interleukin 1 beta Rattus norvegicus 50-58 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 198-217 phospholipase A2 group IB Homo sapiens 32-39 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 198-217 phospholipase A2 group IB Homo sapiens 58-65 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 219-221 phospholipase A2 group IB Homo sapiens 32-39 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 219-221 phospholipase A2 group IB Homo sapiens 58-65 9032461-9 1997 Thus it appears that Lys-69 is at least partially involved in the PA specificity of hs-PLA2 and Glu-56 in the distinction between PE and PC. Phosphatidylcholines 137-139 phospholipase A2 group IB Homo sapiens 84-91 9116917-0 1997 Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells. Phosphatidylcholines 209-228 angiotensinogen Rattus norvegicus 175-189 9116917-0 1997 Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells. Phosphatidylcholines 209-228 angiotensinogen Rattus norvegicus 191-197 9001227-3 1997 Previous studies implicated hydrolysis of phosphatidylcholine (PC) in Raf activation; therefore, we investigated the role of the epsilon isotype of protein kinase C (PKC), which is stimulated by PC-derived diacylglycerol, as a Raf activator. Phosphatidylcholines 63-65 zinc fingers and homeoboxes 2 Mus musculus 70-73 9162748-2 1997 ApoA-I bound to phosphatidylcholine (PC) vesicles with higher affinity and lower capacity compared to triglyceride-PC emulsions. Phosphatidylcholines 16-35 apolipoprotein A1 Homo sapiens 0-6 9074950-0 1997 Dexamethasone increases beta 2-adrenoceptor-regulated phosphatidylcholine secretion in rat alveolar type II cells. Phosphatidylcholines 54-73 adrenoceptor beta 2 Rattus norvegicus 24-43 9162746-0 1997 Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction. Phosphatidylcholines 63-82 apolipoprotein A1 Homo sapiens 146-164 9162746-0 1997 Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction. Phosphatidylcholines 63-82 lecithin-cholesterol acyltransferase Homo sapiens 198-234 9162746-5 1997 The activation energy of LCAT was lower for rHDL containing long chain polyunsaturated fatty acids (PUFA) compared to rHDL containing 100% POPC or 10% PC/90% OPPC ether. Phosphatidylcholines 141-143 lecithin-cholesterol acyltransferase Homo sapiens 25-29 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Phosphatidylcholines 218-237 interleukin 1 beta Homo sapiens 24-42 9075205-6 1997 The concentration of phosphatidylcholine, the acyl donor in the LCAT reaction, was decreased significantly, whereas all other phospholipids were unaffected. Phosphatidylcholines 21-40 lecithin-cholesterol acyltransferase Homo sapiens 64-68 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Phosphatidylcholines 218-237 interleukin 1 beta Homo sapiens 44-53 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Phosphatidylcholines 239-241 interleukin 1 beta Homo sapiens 24-42 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Phosphatidylcholines 239-241 interleukin 1 beta Homo sapiens 44-53 9096895-2 1997 An increase in the arachidonic acid content of a particular fraction of phosphatidylcholine (PC2), phosphatidylethanolamine and phosphatidylinositol between 10 and 20 days of age could be observed in the papilla, and these levels were maintained into adulthood, while in the 20:4 content of phosphatidylserine changes were found between 30-day-old rats and adults. Phosphatidylcholines 72-91 proprotein convertase subtilisin/kexin type 2 Rattus norvegicus 93-96 9006000-5 1997 Phosphatidylinositol (PI), phosphatidylcholine, and a fluorescently labeled derivative of phosphatidylethanolamine (R-PE) are each transferred by LBP from membranes to HDL particles. Phosphatidylcholines 27-46 lipopolysaccharide binding protein Homo sapiens 146-149 8995259-1 1997 Human LCAT prefers phosphatidylcholine (PC) with sn-1-palmitoyl-2-oleoyl PC (POPC) as substrate for cholesteryl ester synthesis, whereas rat LCAT (which is 92% similar in amino acid sequence) prefers sn-1-palmitoyl-2-arachidonoyl PC (PAPC). Phosphatidylcholines 19-38 lecithin cholesterol acyltransferase Rattus norvegicus 6-10 8995259-1 1997 Human LCAT prefers phosphatidylcholine (PC) with sn-1-palmitoyl-2-oleoyl PC (POPC) as substrate for cholesteryl ester synthesis, whereas rat LCAT (which is 92% similar in amino acid sequence) prefers sn-1-palmitoyl-2-arachidonoyl PC (PAPC). Phosphatidylcholines 40-42 lecithin cholesterol acyltransferase Rattus norvegicus 6-10 9013799-7 1997 In a reconstituted system with heparin and phosphatidylcholine, 15-HPETE decreased the ability of heparin to inactivate thrombin activity. Phosphatidylcholines 43-62 coagulation factor II, thrombin Homo sapiens 120-128 9108688-0 1997 Electron transfer between myoglobin and electrodes in thin films of phosphatidylcholines and dihexadecylphosphate. Phosphatidylcholines 68-88 myoglobin Homo sapiens 26-35 9108688-1 1997 Myoglobin (Mb) in thin films of phosphatidyl cholines (PC) or dihexadecyl phosphate (DHP) gave direct, reversible electron transfer between pyrolytic graphite electrodes and the heme Fe(III)/Fe(II) redox couple of the protein. Phosphatidylcholines 32-53 myoglobin Homo sapiens 0-9 9108688-1 1997 Myoglobin (Mb) in thin films of phosphatidyl cholines (PC) or dihexadecyl phosphate (DHP) gave direct, reversible electron transfer between pyrolytic graphite electrodes and the heme Fe(III)/Fe(II) redox couple of the protein. Phosphatidylcholines 55-57 myoglobin Homo sapiens 0-9 9096895-3 1997 In the other fraction of phosphatidylcholine (PC1), saturated fatty acids such as 16:0 and 14:0 decreased, while no changes occurred in the stearic acid (18:0) content. Phosphatidylcholines 25-44 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 46-49 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 insulin Cricetulus griseus 112-119 9202883-2 1997 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). Phosphatidylcholines 221-240 phospholipase A2 group IB Homo sapiens 0-4 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 interleukin 6 Homo sapiens 143-148 22358535-0 1997 Evidence that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of gene expression from human cytomegalovirus promoter in CHO cells. Phosphatidylcholines 14-33 insulin Cricetulus griseus 87-94 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 insulin Cricetulus griseus 291-298 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 interleukin 6 Homo sapiens 433-438 9297603-3 1997 A mixed micelle (phosphatidylcholine (PC):lysoPC (LPC):oleic acid (OA): 2:1:1) significantly increased the release of radiolabelled products from a C-labelled poly(ester-urethane) (TDI/PCL/ED) caused by CE. Phosphatidylcholines 17-36 carboxyl ester lipase Homo sapiens 203-205 9101129-6 1997 Since PC appears to promote the breakdown of collagen, there is reasonable hope that this treatment may affect not only the progression of the disease, but may also reverse preexisting fibrosis, as demonstrated for CCl4-induced cirrhosis in the rat. Phosphatidylcholines 6-8 C-C motif chemokine ligand 4 Rattus norvegicus 215-219 8977419-5 1997 Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine). Phosphatidylcholines 152-171 interleukin 1 beta Rattus norvegicus 15-24 9297603-3 1997 A mixed micelle (phosphatidylcholine (PC):lysoPC (LPC):oleic acid (OA): 2:1:1) significantly increased the release of radiolabelled products from a C-labelled poly(ester-urethane) (TDI/PCL/ED) caused by CE. Phosphatidylcholines 38-40 carboxyl ester lipase Homo sapiens 203-205 9297603-6 1997 PLA caused a small but significant release of radiolabel from TDI/PCL/ED which was enhanced in the presence of its substrate, PC, and a mixture of PC with its breakdown products, LPC and OA. Phosphatidylcholines 66-68 phospholipase A2 group IB Homo sapiens 0-3 9297603-6 1997 PLA caused a small but significant release of radiolabel from TDI/PCL/ED which was enhanced in the presence of its substrate, PC, and a mixture of PC with its breakdown products, LPC and OA. Phosphatidylcholines 126-128 phospholipase A2 group IB Homo sapiens 0-3 9120762-2 1997 IL-6 was lecithinized by covalently binding it with a phosphatidylcholine (lecithin, PC) derivative. Phosphatidylcholines 54-73 interleukin 6 Mus musculus 0-4 16793657-2 1997 The adhesion of platelets stimulated with thrombin or ADP was dramatically increased when the platelet cholesterol content was enriched by incubation with cholesterol containing phosphatidylcholine vesicles. Phosphatidylcholines 178-197 coagulation factor II, thrombin Homo sapiens 42-50 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. Phosphatidylcholines 107-126 phospholipase A2 group IB Rattus norvegicus 66-82 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. Phosphatidylcholines 107-126 phospholipase A2 group IB Rattus norvegicus 84-88 9453451-5 1997 In SOC rats the activity of phosphatidylcholine-PLA2 and PE-PLA2, the activity of PLC, and the mass of COX were significantly greater in medullary tubules than in cortical tubules. Phosphatidylcholines 28-47 phospholipase A2 group IB Rattus norvegicus 48-52 9553941-7 1997 The electrokinetic data for PS and PC liposomes are in good agreement with the modified theory and correlate well with the Gd3+ association constants of 5.10(4) and 10(3) M-1, respectively. Phosphatidylcholines 35-37 GRDX Homo sapiens 123-126 8981360-0 1997 Phosphatidylcholine signaling in response to CSF-1. Phosphatidylcholines 0-19 colony stimulating factor 1 (macrophage) Mus musculus 45-50 8981360-4 1997 Degradation of phosphatidylcholine after CSF-1 stimulation is mediated by a phospholipase C, and the release of diacylglycerol during G1 phase is biphasic. Phosphatidylcholines 15-34 colony stimulating factor 1 (macrophage) Mus musculus 41-46 9007991-5 1997 As monitored by anti-factor IX:Ca (II)-specific antibodies and by the quenching of intrinsic fluorescence, all these factor IX species underwent the Ca(II)-induced conformational transition required for phospholipid membrane binding and bound equivalently to phospholipid vesicles composed of phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Phosphatidylcholines 313-332 carbonic anhydrase 2 Homo sapiens 149-155 8981360-6 1997 The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation. Phosphatidylcholines 19-38 FBJ osteosarcoma oncogene Mus musculus 86-91 8981360-6 1997 The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation. Phosphatidylcholines 19-38 jun B proto-oncogene Mus musculus 96-100 8981360-6 1997 The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation. Phosphatidylcholines 19-38 colony stimulating factor 1 (macrophage) Mus musculus 289-294 9060137-3 1997 In addition to the decrease in LCAT activity, the concentrations of phosphatidylcholine (a fatty aryl donor for esterification of free cholesterol) and of cholesteryl esters (products of the LCAT reaction) were reduced in the high-density lipoprotein fractions from cows with fatty livers. Phosphatidylcholines 68-87 lecithin-cholesterol acyltransferase Homo sapiens 191-195 9454375-0 1997 [Effects of fatty acid amides on phosphatidylcholine hydrolysis catalyzed by phospholipase A2 in micelles]. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 77-93 9454375-1 1997 The effect of fatty acid amides on the hydrolysis of natural phosphatidylcholine and its semisynthetic analog, dioleoyl phosphatidylcholine, catalyzed by phospholipase A2 in mixed micelles with Triton X-100 has been studied. Phosphatidylcholines 61-80 phospholipase A2 group IB Homo sapiens 154-170 9060137-5 1997 These results suggest that the decreased LCAT activity, which may be attributable to impaired hepatic secretion or to the suppression of the activity in the plasma by reduced concentrations of phosphatidylcholine and apolipoprotein A-I, resulted in the lower concentrations of cholesteryl esters. Phosphatidylcholines 193-212 lecithin-cholesterol acyltransferase Bos taurus 41-45 9003363-5 1996 Analysis of the fractions using exogenous phosphatidylcholine as substrate confirmed the presence of ARF1-dependent PLD activity in endomembranes and plasma membrane, and also identified an additional activity in the cytosol. Phosphatidylcholines 42-61 ADP ribosylation factor 1 Homo sapiens 101-105 9003363-5 1996 Analysis of the fractions using exogenous phosphatidylcholine as substrate confirmed the presence of ARF1-dependent PLD activity in endomembranes and plasma membrane, and also identified an additional activity in the cytosol. Phosphatidylcholines 42-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 8978464-9 1996 These results strongly suggest that bFGF activates phosphatidylcholine-hydrolyzing phospholipase D through the activation of tyrosine kinase, but independently of PKC activated by phosphoinositide hydrolysis in osteoblast-like cells. Phosphatidylcholines 51-70 fibroblast growth factor 2 Mus musculus 36-40 8978672-1 1996 The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis. Phosphatidylcholines 238-257 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 49-55 8978464-0 1996 Basic fibroblast growth factor stimulates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells. Phosphatidylcholines 42-61 fibroblast growth factor 2 Mus musculus 0-30 8978464-1 1996 We examined the effect of basic fibroblast growth factor (bFGF) on the activation of phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 85-104 fibroblast growth factor 2 Mus musculus 26-56 8978464-1 1996 We examined the effect of basic fibroblast growth factor (bFGF) on the activation of phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 85-104 fibroblast growth factor 2 Mus musculus 58-62 8961931-9 1996 Using flavocytochrome b558 reconstituted into phosphatidylcholine vesicles, the EC50 for Rac1 but not Rac2 decreased (increased binding) when an acidic phospholipid (phosphatidylinositol) was present, supporting a role for the Rac1 polybasic C terminus in binding to the membrane. Phosphatidylcholines 46-65 Rac family small GTPase 1 Homo sapiens 89-93 8938187-2 1996 After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet. Phosphatidylcholines 202-221 spindlin 1 Homo sapiens 52-56 8997228-0 1996 Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase. Phosphatidylcholines 27-47 lecithin cholesterol acyltransferase Rattus norvegicus 81-85 8997228-0 1996 Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase. Phosphatidylcholines 27-47 lipase C, hepatic type Rattus norvegicus 90-104 8996638-0 1996 Role of stearoyl-CoA desaturase in the modification of acyl composition of hepatic phosphatidylcholine by peroxisome proliferators. Phosphatidylcholines 83-102 stearoyl-CoA desaturase Rattus norvegicus 8-31 8996638-3 1996 With administration of these peroxisome proliferators, the proportion of oleic acid in C-2 position of PtdCho in hepatic microsomes was increased in commensurate with the increase in activities of stearoyl-CoA desaturase and 1-acyl-GPC acyltransferase. Phosphatidylcholines 103-109 stearoyl-CoA desaturase Rattus norvegicus 197-220 8938187-2 1996 After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet. Phosphatidylcholines 223-225 spindlin 1 Homo sapiens 52-56 8940023-3 1996 The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A). Phosphatidylcholines 261-280 Harvey rat sarcoma viral oncogene homolog L homeolog Xenopus laevis 108-113 8931495-1 1996 Nerve growth cones isolated from fetal rat brain exhibit in their cytosol a robust level of phospholipase A2 activity hydrolyzing phosphatidylinositol (PI) and phosphatidylethanolamine (PE) but not phosphatidylcholine (PC). Phosphatidylcholines 219-221 phospholipase A2 group IB Rattus norvegicus 92-108 9131406-7 1996 By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and UTP. Phosphatidylcholines 302-321 protein kinase C, alpha Rattus norvegicus 90-99 9131406-7 1996 By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and UTP. Phosphatidylcholines 302-321 protein kinase C, alpha Rattus norvegicus 90-93 8940040-5 1996 Only the apoE-secreting cells and only in the presence of 8-Br-cAMP released large amounts of labeled cholesterol or phosphatidylcholine into the medium. Phosphatidylcholines 117-136 apolipoprotein E Homo sapiens 9-13 8940023-3 1996 The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A). Phosphatidylcholines 261-280 Harvey rat sarcoma viral oncogene homolog L homeolog Xenopus laevis 108-113 8940023-3 1996 The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A). Phosphatidylcholines 261-280 Harvey rat sarcoma viral oncogene homolog L homeolog Xenopus laevis 108-113 8941338-1 1996 The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV). Phosphatidylcholines 68-87 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 38-53 8939917-12 1996 D609, an inhibitor of phosphatidylcholine-specific phospholipase C, completely prevented the killing by TNF, but not by ceramide, in the presence of ActD. Phosphatidylcholines 22-41 tumor necrosis factor Homo sapiens 104-107 8941338-1 1996 The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV). Phosphatidylcholines 68-87 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 55-61 8941338-1 1996 The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV). Phosphatidylcholines 89-91 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 38-53 8941338-1 1996 The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV). Phosphatidylcholines 89-91 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 55-61 8944749-9 1996 A novel method for continuous assay of phospholipase A2 activity with BSA-HCA and a mixed phosphatidylcholine/CHAPS micellar substrate is reported. Phosphatidylcholines 90-109 phospholipase A2 group IB Homo sapiens 39-55 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 60-79 protein kinase C alpha Homo sapiens 214-217 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 81-87 protein kinase C alpha Homo sapiens 214-217 8910539-4 1996 Stable expression of PKC-alpha in MCF-7 cells, which was accompanied by increased levels of the betaI- and theta-isoforms as well, greatly enhanced both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydrolysis of PtdEtn (2.5-2.9-fold) and PtdCho (5.5-7.2-fold). Phosphatidylcholines 282-288 protein kinase C alpha Homo sapiens 21-30 8941649-4 1996 In addition, we have recently shown that HDL3 stimulates the hydrolysis of phosphatidylcholine (PC) in cholesterol-loaded fibroblasts. Phosphatidylcholines 75-94 HDL3 Homo sapiens 41-45 8941649-4 1996 In addition, we have recently shown that HDL3 stimulates the hydrolysis of phosphatidylcholine (PC) in cholesterol-loaded fibroblasts. Phosphatidylcholines 96-98 HDL3 Homo sapiens 41-45 8941649-5 1996 To investigate whether this cell signaling pathway is involved in cholesterol efflux mechanisms, we compared the HDL3-induced PC hydrolysis in normal fibroblasts and in fibroblasts from a TD kindred, in whom the HDL3- and apolipoprotein A-I (apo A-I)-induced mobilization of cellular cholesterol was found to be reduced by 50%. Phosphatidylcholines 126-128 HDL3 Homo sapiens 113-117 8961306-4 1996 In the present report we demonstrate by immunofluorescence that short-treatment of C 6 glial cells with phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC), changes the intracellular localization of protein kinase C (PKC) zeta from the cytoplasm to a perinuclear region. Phosphatidylcholines 104-123 protein kinase C zeta Homo sapiens 222-225 8914830-1 1996 Electron spin resonance (ESR) spectroscopy and spin label techniques have been used to study the effects of fumonisin B1 (FB1) and hydrolyzed fumonisin backbone (AP1) on the structural and dynamic properties of phosphatidylcholine membranes at the molecular level. Phosphatidylcholines 211-230 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 162-165 8898203-0 1996 MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 8898203-0 1996 MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 1 Homo sapiens 5-19 8898203-0 1996 MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 71-75 8898203-0 1996 MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 1 Homo sapiens 76-90 8898203-2 1996 The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile. Phosphatidylcholines 40-59 ATP binding cassette subfamily B member 4 Homo sapiens 15-19 8898203-2 1996 The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile. Phosphatidylcholines 40-59 ATP binding cassette subfamily B member 1 Homo sapiens 20-23 8898203-6 1996 MDR3 cells exclusively released a short-chain phosphatidylcholine. Phosphatidylcholines 46-65 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 8978486-1 1996 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 8978486-1 1996 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 8901526-2 1996 We used ellipsometry to study the binding of beta 2GPI and the beta 2GPI-mediated binding of ACA to planar membranes composed of phosphatidylcholine (PC) and 5-20 mol % phosphatidylserine (PS). Phosphatidylcholines 129-148 apolipoprotein H Homo sapiens 63-72 8901526-2 1996 We used ellipsometry to study the binding of beta 2GPI and the beta 2GPI-mediated binding of ACA to planar membranes composed of phosphatidylcholine (PC) and 5-20 mol % phosphatidylserine (PS). Phosphatidylcholines 150-152 apolipoprotein H Homo sapiens 63-72 8876250-1 1996 The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes. Phosphatidylcholines 167-186 microsomal triglyceride transfer protein Homo sapiens 51-54 8957238-4 1996 We show that both drugs inhibit, in an equimolar manner, the activity of phospholipase A1 (assayed for phosphatidylcholine, included in negatively charged liposomes), in a way consistent with the model of "charge neutralization" proposed already for gentamicin (Mingeot-Leclercq et al., 1988, Biochem. Phosphatidylcholines 103-122 lipase H Homo sapiens 73-89 8824283-8 1996 All glycosaminoglycans tested, at concentrations up to 100 microM, increased the activity of phospholipase A2 toward phosphatidylcholine liposomes. Phosphatidylcholines 117-136 phospholipase A2 group IB Homo sapiens 93-109 8930892-3 1996 Thrombin and carbachol induce comparable changes in phosphoinositide and phosphatidylcholine hydrolysis, mobilization of intracellular Ca2+, diglyceride generation, and redistribution of protein kinase C; thus, activation of these Gq-signaling pathways appears to be insufficient for gene expression and mitogenesis. Phosphatidylcholines 73-92 coagulation factor II, thrombin Homo sapiens 0-8 8810347-0 1996 The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast. Phosphatidylcholines 12-31 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 70-74 8810270-4 1996 Association of as little as 5 mol of phosphatidylcholine with apoA-I is sufficient to transform lipid-free apoA-I into a distinct lipoprotein-like particle that is a significantly better acceptor of cellular cholesterol. Phosphatidylcholines 37-56 apolipoprotein A1 Homo sapiens 62-68 8810270-4 1996 Association of as little as 5 mol of phosphatidylcholine with apoA-I is sufficient to transform lipid-free apoA-I into a distinct lipoprotein-like particle that is a significantly better acceptor of cellular cholesterol. Phosphatidylcholines 37-56 apolipoprotein A1 Homo sapiens 107-113 8810347-7 1996 Rather, we report that when the rate of synthesis of PC becomes growth limiting, the addition of inositol fails to repress the phospholipid biosynthetic genes, but when the rate of PC synthesis is sufficient to sustain normal growth, the addition of inositol to the growth medium has the effect of repressing INO1 and other phospholipid biosynthetic genes. Phosphatidylcholines 53-55 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 309-313 8810347-2 1996 In yeast, PC biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol. Phosphatidylcholines 10-12 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 111-115 8810347-4 1996 We report that repression of INO1 transcription in response to inositol is clearly dependent on ongoing PC biosynthesis, but it is independent of the route of synthesis. Phosphatidylcholines 104-106 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 29-33 8855796-9 1996 The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho. Phosphatidylcholines 89-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 8798752-2 1996 In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol. Phosphatidylcholines 106-125 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-68 8897886-5 1996 Lysophosphatidylcholine (lysoPC) (0.01-5,000 ng/ml), one of the products of phosphatidylcholine by PLA2, dose-dependently enhanced IEC-6 cell migration as well. Phosphatidylcholines 4-23 phospholipase A2 group IB Rattus norvegicus 99-103 8857918-1 1996 Triglycerides (TGs), cholesteryl esters (CEs), cholesterol, and phosphatidylcholine have been independently proposed as playing regulatory roles in apoB-100 secretion; the results depended on the cellular model used. Phosphatidylcholines 64-83 apolipoprotein B Homo sapiens 148-156 8894140-0 1996 Function of Ca2+ in phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblast-like cells. Phosphatidylcholines 20-39 carbonic anhydrase 2 Mus musculus 12-15 8894140-1 1996 We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 58-77 carbonic anhydrase 2 Mus musculus 32-35 8894140-1 1996 We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 79-81 carbonic anhydrase 2 Mus musculus 32-35 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 116-135 interleukin 1 beta Rattus norvegicus 33-42 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 116-135 phospholipase A2 group IB Rattus norvegicus 69-85 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 116-135 phospholipase A2 group IB Rattus norvegicus 87-91 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 137-139 interleukin 1 beta Rattus norvegicus 33-42 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 137-139 phospholipase A2 group IB Rattus norvegicus 69-85 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 137-139 phospholipase A2 group IB Rattus norvegicus 87-91 8855796-9 1996 The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho. Phosphatidylcholines 184-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 8905167-4 1996 Circulating [3H]PAM is incorporated into sn-1 positions of brain phospholipids, mainly phosphatidylcholine, and its rate of turnover is thought to reflect turnover of neuronal and glial membranes. Phosphatidylcholines 87-106 peptidylglycine alpha-amidating monooxygenase Rattus norvegicus 16-19 8794341-13 1996 Liposomes composed of phosphatidylcholine and microsomes (to simulate ER membranes) were broken when observed by electron microscopy after incubation with NSP4 or the NSP4(114-135) peptide. Phosphatidylcholines 22-41 serine protease 57 Homo sapiens 155-159 8794341-13 1996 Liposomes composed of phosphatidylcholine and microsomes (to simulate ER membranes) were broken when observed by electron microscopy after incubation with NSP4 or the NSP4(114-135) peptide. Phosphatidylcholines 22-41 serine protease 57 Homo sapiens 167-171 9414418-6 1996 HePC inhibited fMLP induced phosphatidylinositol-specific PLC activation in HL60 cells and TNF-alpha induced activation of phosphatidylcholine-specific PLC in U937 cells. Phosphatidylcholines 123-142 tumor necrosis factor Homo sapiens 91-100 8798386-0 1996 Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis. Phosphatidylcholines 187-206 mitogen-activated protein kinase 1 Homo sapiens 50-54 8798386-9 1996 Our data suggest that phosphatidylinositol 3-kinase and phosphatidylcholine-specific phospholipase C represent components of different, but partly overlapping pathways that can account almost entirely for the activation of ERK2 by the 5-HT1A receptor. Phosphatidylcholines 56-75 mitogen-activated protein kinase 1 Homo sapiens 223-227 8798386-9 1996 Our data suggest that phosphatidylinositol 3-kinase and phosphatidylcholine-specific phospholipase C represent components of different, but partly overlapping pathways that can account almost entirely for the activation of ERK2 by the 5-HT1A receptor. Phosphatidylcholines 56-75 5-hydroxytryptamine receptor 1A Homo sapiens 235-250 8856074-7 1996 In membranes of toxin-B-treated cells, basal and GTP[S]-stimulated PLD activities were reduced, when measured with exogenous phosphatidylcholine as enzyme substrate. Phosphatidylcholines 125-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8856074-8 1996 Inclusion of PtdIns(4,5)P2 with phosphatidylcholine in the substrate vesicles or addition of PtdIns(4,5)P2 fully restored basal and GTP[S]-stimulated PLD activities in membranes of toxin-B-treated cells. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 150-153 8843783-0 1996 TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes is sequentially mediated by PGE2 and NO. Phosphatidylcholines 32-34 tumor necrosis factor Homo sapiens 0-9 8843783-5 1996 The D-[U-14C] glucose incorporation into phosphatidylcholine (PC) was selectively inhibited by TNF-alpha, PGE2, sodium nitroprusside (SNP), or 8-bromoguanosine 3",5"-cyclic monophosphate. Phosphatidylcholines 41-60 tumor necrosis factor Homo sapiens 95-104 8843783-5 1996 The D-[U-14C] glucose incorporation into phosphatidylcholine (PC) was selectively inhibited by TNF-alpha, PGE2, sodium nitroprusside (SNP), or 8-bromoguanosine 3",5"-cyclic monophosphate. Phosphatidylcholines 62-64 tumor necrosis factor Homo sapiens 95-104 8843783-10 1996 Our results suggest that NO generation, secondary to PGE2 production, is responsible for the TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes. Phosphatidylcholines 125-127 tumor necrosis factor Homo sapiens 93-102 9011184-1 1996 Using fluorescent probe 4-(dimethylaminostyryl)-1-methylpridine n-toluenesulfonate (DSM) the effect of ribonuslease and lysozyme on the structure of liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been studied. Phosphatidylcholines 171-190 lysozyme Homo sapiens 120-128 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 102-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8906563-2 1996 Correlation with metabolism of membrane phospholipids suggests that PKC-alpha and MARCKS may be required to mediate phosphatidylcholine turnover stimulated by phorbol ester (beta-TPA). Phosphatidylcholines 116-135 protein kinase C alpha Homo sapiens 68-77 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 123-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906563-2 1996 Correlation with metabolism of membrane phospholipids suggests that PKC-alpha and MARCKS may be required to mediate phosphatidylcholine turnover stimulated by phorbol ester (beta-TPA). Phosphatidylcholines 116-135 myristoylated alanine rich protein kinase C substrate Homo sapiens 82-88 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 102-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 123-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8906563-8 1996 Thus, induced differentiation of human neuroblastoma cells involved increased expression of PKC-alpha and MARCKS and synthesis of phosphatidylcholine, consistent with involvement of PKC-alpha and MARCKS in regulation of phosphatidylcholine turnover during neurite growth. Phosphatidylcholines 220-239 protein kinase C alpha Homo sapiens 182-191 8906563-8 1996 Thus, induced differentiation of human neuroblastoma cells involved increased expression of PKC-alpha and MARCKS and synthesis of phosphatidylcholine, consistent with involvement of PKC-alpha and MARCKS in regulation of phosphatidylcholine turnover during neurite growth. Phosphatidylcholines 220-239 myristoylated alanine rich protein kinase C substrate Homo sapiens 196-202 8877882-10 1996 Phosphatidylcholine, a substrate for the gene product of the class III P-gp gene, produced significant inhibition of [3H]DNM transport (30.6% at a 10-fold-higher substrate concentration), suggesting that transport may be mediated, at least in part, by this P-gp gene product. Phosphatidylcholines 0-19 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 71-75 8877882-10 1996 Phosphatidylcholine, a substrate for the gene product of the class III P-gp gene, produced significant inhibition of [3H]DNM transport (30.6% at a 10-fold-higher substrate concentration), suggesting that transport may be mediated, at least in part, by this P-gp gene product. Phosphatidylcholines 0-19 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 257-261 8831934-12 1996 An extensive hydrolysis of the endogenous phosphatidylcholine (PC) to lysophosphatidylcholine (lyso-PC) was observed during Lp(a) oxidation, since the Lyso-PC/sphingomyelin molar ratio at the end of oxidation (0.55 +/- 0.09) was significantly higher than that before oxidation (0.19 +/- 0.01, P < 0.001). Phosphatidylcholines 42-61 lipoprotein(a) Homo sapiens 124-129 8888372-8 1996 These results suggest that the cytidine moiety of CDP-choline stimulates phosphatidylcholine synthesis in human brain cell membranes in older subjects. Phosphatidylcholines 73-92 cut like homeobox 1 Homo sapiens 50-53 8831934-12 1996 An extensive hydrolysis of the endogenous phosphatidylcholine (PC) to lysophosphatidylcholine (lyso-PC) was observed during Lp(a) oxidation, since the Lyso-PC/sphingomyelin molar ratio at the end of oxidation (0.55 +/- 0.09) was significantly higher than that before oxidation (0.19 +/- 0.01, P < 0.001). Phosphatidylcholines 63-65 lipoprotein(a) Homo sapiens 124-129 8831934-15 1996 During Lp(a) oxidation, the PAF-AH activity decreases whereas an extensive hydrolysis of the endogenous PC to Lyso-PC is observed which is possibly due to the PAF-AH activity. Phosphatidylcholines 104-106 lipoprotein(a) Homo sapiens 7-12 8831934-15 1996 During Lp(a) oxidation, the PAF-AH activity decreases whereas an extensive hydrolysis of the endogenous PC to Lyso-PC is observed which is possibly due to the PAF-AH activity. Phosphatidylcholines 104-106 phospholipase A2 group VII Homo sapiens 159-165 8960386-2 1996 In the present study, we investigated the susceptibility of the phosphatidylcholine component of two exogenous surfactants, Exosurf and Survanta, to secretory-type phospholipase A2 (PLA2) deacylation in vitro. Phosphatidylcholines 64-83 phospholipase A2 group IB Homo sapiens 164-180 8842223-2 1996 Binding of cytochrome c to cardiolipin/phosphatidylcholine membranes in the absence of oxidase. Phosphatidylcholines 39-58 LOC104968582 Bos taurus 11-23 8842223-3 1996 The mechanism of interaction between cytochrome c and a solid-supported planar phosphatidylcholine membrane containing varying amounts of cardiolipin (0-20 mol%) has been studied over a wide range of protein concentrations (0-450 microM) and ionic strength conditions (10-150 mM), by direct measurement of protein binding using surface plasmon resonance (SPR) spectroscopy. Phosphatidylcholines 79-98 LOC104968582 Bos taurus 37-49 8842224-2 1996 Binding of cytochrome c to oxidase-containing cardiolipin/phosphatidylcholine membranes. Phosphatidylcholines 58-77 LOC104968582 Bos taurus 11-23 8842224-3 1996 Complex formation between horse heart cytochrome c (cyt c) and bovine cytochrome c oxidase (cco) incorporated into a supported planar egg phosphatidylcholine membrane containing varying amounts of cardiolipin (CL) (0-20 mol%) has been studied under low (10 mM) and medium (160 mM) ionic strength conditions by surface plasmon resonance (SPR) spectroscopy. Phosphatidylcholines 138-157 cytochrome c, somatic Equus caballus 52-57 8842224-3 1996 Complex formation between horse heart cytochrome c (cyt c) and bovine cytochrome c oxidase (cco) incorporated into a supported planar egg phosphatidylcholine membrane containing varying amounts of cardiolipin (CL) (0-20 mol%) has been studied under low (10 mM) and medium (160 mM) ionic strength conditions by surface plasmon resonance (SPR) spectroscopy. Phosphatidylcholines 138-157 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 70-90 8962916-2 1996 The data indicate that in lymphocyte membranes, enzymatic system of cascade deacylation of the phosphatidylcholine fraction includes calcium-activated phospholipase A1 and lysophospholipase. Phosphatidylcholines 95-114 phospholipase A2 group IVA Homo sapiens 172-189 8960386-2 1996 In the present study, we investigated the susceptibility of the phosphatidylcholine component of two exogenous surfactants, Exosurf and Survanta, to secretory-type phospholipase A2 (PLA2) deacylation in vitro. Phosphatidylcholines 64-83 phospholipase A2 group IB Homo sapiens 182-186 8960386-4 1996 The phosphatidylcholine component of Survanta was readily deacylated by PLA2, whereas the dipalmitoylphosphatidycholine (DPPC) component of Exosurf was resistant over the entire duration of the assay. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 72-76 8760826-0 1996 Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock. Phosphatidylcholines 78-97 tumor necrosis factor Mus musculus 20-41 8760826-0 1996 Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock. Phosphatidylcholines 78-97 tumor necrosis factor Mus musculus 124-145 8760826-0 1996 Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock. Phosphatidylcholines 78-97 tumor necrosis factor Mus musculus 147-150 8760826-1 1996 We have investigated the role of a TNF-responsive phosphatidylcholine-specific phospholipase C (PC-PLC) for the cytotoxic and proinflammatory activity of TNF. Phosphatidylcholines 50-69 tumor necrosis factor Mus musculus 35-38 8760826-1 1996 We have investigated the role of a TNF-responsive phosphatidylcholine-specific phospholipase C (PC-PLC) for the cytotoxic and proinflammatory activity of TNF. Phosphatidylcholines 50-69 tumor necrosis factor Mus musculus 154-157 8666200-1 1996 Cells of the pel1 mutant of Saccharomyces cerevisiae were found to contain an extremely low content of cardiolipin, a decreased level of phosphatidylcholine and an increased level of phosphatidylinositol. Phosphatidylcholines 137-156 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 13-17 8695654-2 1996 Inhibition of cholesterol esterification in HepG2 cells, by the ACAT inhibitor 447C88, partially reduced the secretion of labelled total cholesterol, but the secretion of apoprotein B mass, and of radiolabelled triacylglycerol and phosphatidylcholine were unaffected. Phosphatidylcholines 231-250 sterol O-acyltransferase 1 Homo sapiens 64-68 8695654-4 1996 In contrast, the less potent ACAT inhibitor, CL277,082, significantly decreased secretion of labelled triacylglycerol, phosphatidylcholine and total cholesterol, in a manner which mirrored the decreases in secretion of apoB. Phosphatidylcholines 119-138 sterol O-acyltransferase 1 Homo sapiens 29-33 8804611-2 1996 Here we have used SPR spectroscopy for the first time to monitor the binding and activation of G-protein (transducin or Gt) by bovine rhodopsin incorporated into an egg phosphatidylcholine bilayer deposited on a silver film. Phosphatidylcholines 169-188 rhodopsin Bos taurus 134-143 8770926-0 1996 Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. Phosphatidylcholines 45-64 insulin Homo sapiens 0-7 8770926-0 1996 Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. Phosphatidylcholines 45-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-34 8770926-2 1996 In particular, insulin effects on the hydrolysis of phosphatidylcholine (PC) and subsequent activation of protein kinase C (PKC) have not been apparent in some studies. Phosphatidylcholines 52-71 insulin Homo sapiens 15-22 8770926-2 1996 In particular, insulin effects on the hydrolysis of phosphatidylcholine (PC) and subsequent activation of protein kinase C (PKC) have not been apparent in some studies. Phosphatidylcholines 73-75 insulin Homo sapiens 15-22 8770926-4 1996 We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol. Phosphatidylcholines 96-98 insulin Homo sapiens 14-21 8770926-4 1996 We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-65 8770926-4 1996 We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8647917-0 1996 Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis. Phosphatidylcholines 64-83 coagulation factor II Mus musculus 0-8 8647917-1 1996 We examined the effect of thrombin on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 38-57 coagulation factor II Mus musculus 26-34 8647917-14 1996 These results suggest that thrombin stimulates phosphatidylcholine-hydrolyzing phospholipase D due to self-induced Ca2+ influx independently of protein kinase C activation in osteoblast-like cells and that its proliferative effect depends on phospholipase D activation. Phosphatidylcholines 47-66 coagulation factor II Mus musculus 27-35 8764605-1 1996 Phospholipase D activity of rat brain neuronal nuclei, measured with exogenous phosphatidylcholine as substrate, was characterized. Phosphatidylcholines 79-98 RNA binding fox-1 homolog 3 Rattus norvegicus 38-53 8768693-8 1996 These data suggest that phosphatidylcholine-specific phospholipase C is involved in the ANG II signaling pathway leading to stimulation of L-type Ca++ channels by protein kinase C. Phosphatidylcholines 24-43 angiotensinogen Rattus norvegicus 88-94 8755731-1 1996 Glycophorin A was reconstituted into large unilamellar vesicles of egg phosphatidylcholine by detergent dialysis. Phosphatidylcholines 71-90 glycophorin A (MNS blood group) Homo sapiens 0-13 8783331-9 1996 In addition, the inhibitory effect of TNF alpha on phosphatidylcholine labeling was attenuated in cryopreserved islets compared with noncryopreserved islets. Phosphatidylcholines 51-70 tumor necrosis factor Homo sapiens 38-47 8679568-1 1996 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 115-134 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 8679568-1 1996 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function. Phosphatidylcholines 136-138 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 8679568-8 1996 Endogenous PC in the insect cells fulfills the lipid requirement for the expressed BDH since enzymatic activity is lost upon digestion with phospholipase A2 and restored selectively by reconstitution with PC vesicles. Phosphatidylcholines 11-13 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 83-86 8679568-8 1996 Endogenous PC in the insect cells fulfills the lipid requirement for the expressed BDH since enzymatic activity is lost upon digestion with phospholipase A2 and restored selectively by reconstitution with PC vesicles. Phosphatidylcholines 11-13 phospholipase A2 group IB Homo sapiens 140-156 8679658-4 1996 Removal of endogenous lipids from OG-Glut1 abolished the activity unless phosphatidylcholine was included in the eluent. Phosphatidylcholines 73-92 solute carrier family 2 member 1 Homo sapiens 37-42 8664328-9 1996 L-FABP expression also selectively stimulated [3H]oleic acid incorporation into choline glycerophospholipids. Phosphatidylcholines 80-108 fatty acid binding protein 1 Homo sapiens 0-6 8663014-2 1996 The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB. Phosphatidylcholines 57-76 sphingomyelin phosphodiesterase 1 Homo sapiens 4-27 8663014-2 1996 The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB. Phosphatidylcholines 57-76 sphingomyelin phosphodiesterase 1 Homo sapiens 29-36 8663014-2 1996 The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB. Phosphatidylcholines 57-76 tumor necrosis factor Homo sapiens 161-164 8662812-3 1996 Treatment of macrophages with inhibitors of proteoglycan synthesis (4-methylumbelliferyl-beta-D-xyloside) or sulfation (sodium chlorate) enhanced the release of apoE from cells and significantly attenuated the increase in secretion produced by incubation with phosphatidylcholine vesicles (PV). Phosphatidylcholines 260-279 apolipoprotein E Homo sapiens 161-165 8808758-12 1996 These data collectively provide evidence that TNF-alpha specifically induces the turnover of neutrophil phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine, which are enriched with 20:4(n-6) by the activation of phospholipase A2. Phosphatidylcholines 126-145 tumor necrosis factor Homo sapiens 46-55 8679706-6 1996 The fifth pig Pgp gene shows similarity to the phosphatidylcholine-translocating Class III isoform. Phosphatidylcholines 47-66 phosphoglycolate phosphatase Sus scrofa 14-17 8808758-3 1996 Pretreatment of neutrophils with TNF-alpha caused a rapid increase in the incorporation of [1-14C]20:4(n-6) substrate into cellular phosphatidylinositol and phosphatidic acid and a slower rise in the incorporation into phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 219-238 tumor necrosis factor Homo sapiens 33-42 8649360-0 1996 D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells. Phosphatidylcholines 8-27 interleukin 1 beta Homo sapiens 71-89 8649360-0 1996 D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells. Phosphatidylcholines 8-27 vascular cell adhesion molecule 1 Homo sapiens 98-131 8649360-3 1996 We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta. Phosphatidylcholines 28-47 vascular cell adhesion molecule 1 Homo sapiens 93-99 8649360-3 1996 We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta. Phosphatidylcholines 28-47 interleukin 1 beta Homo sapiens 119-137 8649360-4 1996 D609, a phosphatidylcholine-specific phospholipase C inhibitor, reduced VCAM-1 cell surface expression and VCAM-1 promoter activity in human endothelial cells in a dose-dependent manner. Phosphatidylcholines 8-27 vascular cell adhesion molecule 1 Homo sapiens 72-78 8649360-6 1996 The results of this study indicate that phosphatidylcholine-specific phospholipase C is required for activation of nuclear factor-kappa B and cytokine induction of VCAM-1 gene expression in endothelial cells. Phosphatidylcholines 40-59 vascular cell adhesion molecule 1 Homo sapiens 164-170 8645147-2 1996 Here we demonstrate by two independent methods that Akt-1 from L6 myotubes binds to PtdIns(3,4,5)P3, PtdIns(3,4)P2 and PtdIns(4,5)P2 when presented against a background of phosphatidylserine (PtdSer) or a 1:1 mixture of PtdSer and phosphatidylcholine (PtdCho). Phosphatidylcholines 231-250 AKT serine/threonine kinase 1 Homo sapiens 52-57 8639617-1 1996 The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy. Phosphatidylcholines 145-165 cystathionine beta-synthase Homo sapiens 115-118 8662615-10 1996 Mature TC II-R dimerized upon insertion into synthetic phosphatidylcholine vesicles of different fatty acyl chain length (dimyristoyl, dipalmitoyl, and disteroyl phosphatidylcholine) in the absence or the presence of cholesterol at temperatures below or above their transition temperatures, respectively. Phosphatidylcholines 55-74 transcobalamin 2 Homo sapiens 7-12 8681425-2 1996 Phosphatidylcholine is the major substrate for PLD. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 8681431-3 1996 A phosphatidylcholine-specific PLD activity was recently purified from pig lung, but its possible regulation by PKC has not been reported yet. Phosphatidylcholines 2-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8662651-3 1996 14C-Labeled PC was introduced into the OMV from small unilamellar vesicles by a PC-specific transfer protein (PCTP). Phosphatidylcholines 12-14 phosphatidylcholine transfer protein Rattus norvegicus 80-108 8662651-3 1996 14C-Labeled PC was introduced into the OMV from small unilamellar vesicles by a PC-specific transfer protein (PCTP). Phosphatidylcholines 12-14 phosphatidylcholine transfer protein Rattus norvegicus 110-114 8662651-4 1996 The membrane topology of the newly introduced PC was determined from its accessibility to phospholipase A2. Phosphatidylcholines 46-48 phospholipase A2 group IB Rattus norvegicus 90-106 8662651-5 1996 Under conditions where the OMV stay intact, externally added phospholipase A2 is able to hydrolyze up to 50% of both the introduced [14C]PC and the endogenous PC. Phosphatidylcholines 137-139 phospholipase A2 group IB Rattus norvegicus 61-77 8662651-5 1996 Under conditions where the OMV stay intact, externally added phospholipase A2 is able to hydrolyze up to 50% of both the introduced [14C]PC and the endogenous PC. Phosphatidylcholines 159-161 phospholipase A2 group IB Rattus norvegicus 61-77 8694508-0 1996 Detection of phosphatidylcholine-specific phospholipase C in NIH-3T3 fibroblasts and their H-ras transformants: NMR and immunochemical studies. Phosphatidylcholines 13-32 HRas proto-oncogene, GTPase Homo sapiens 91-96 8694509-1 1996 Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 91-135 8694509-1 1996 Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 137-141 8694509-4 1996 Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis. Phosphatidylcholines 187-206 cut-like homeobox 1 Rattus norvegicus 163-166 8645147-2 1996 Here we demonstrate by two independent methods that Akt-1 from L6 myotubes binds to PtdIns(3,4,5)P3, PtdIns(3,4)P2 and PtdIns(4,5)P2 when presented against a background of phosphatidylserine (PtdSer) or a 1:1 mixture of PtdSer and phosphatidylcholine (PtdCho). Phosphatidylcholines 252-258 AKT serine/threonine kinase 1 Homo sapiens 52-57 8847457-12 1996 Phosphatidylcholine containing [14C]-AA in Sn-2 (150,000 dpm) was incubated with cytosol of uterine myometrium and the amounts of [14C]-AA released were calculated as Phospholipase A2 activity. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 167-183 8805276-1 1996 BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA). Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 8805276-1 1996 BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA). Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 8792123-4 1996 BALF PLA2 showed marked selectivity for phosphatidylcholine containing arachidonic acid (AA) over linoleic or palmitic acids. Phosphatidylcholines 40-59 phospholipase A2 group IB Homo sapiens 5-9 9273720-1 1996 Using fluorescent probes DSM, DSP-6 and DSP-12 interaction of methemoglobin with liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been investigated. Phosphatidylcholines 103-122 hemoglobin subunit gamma 2 Homo sapiens 62-75 8725726-2 1996 TFPI was shown to bind calcium-independently to an acidic phospholipid surface composed of phosphatidylserine, but not a surface composed of the neutral phosphatidylcholine. Phosphatidylcholines 153-172 tissue factor pathway inhibitor Homo sapiens 0-4 8627336-0 1996 Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells. Phosphatidylcholines 106-125 myristoylated alanine rich protein kinase C substrate Homo sapiens 18-24 8664287-1 1996 Bilayers composed of phosphatidylcholine initially resist catalysis by phospholipase A2. Phosphatidylcholines 21-40 phospholipase A2 group IB Homo sapiens 71-87 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 121-140 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 121-140 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8633059-3 1996 This PLD preferentially used PtdCho as substrate. Phosphatidylcholines 29-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 5-8 8633059-8 1996 The results suggest that mammalian PLD reacts nearly selectively with PtdCho in the form of mixed micelles or membranes with other phospholipids, especially PtdEtn. Phosphatidylcholines 70-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 8626542-7 1996 In addition, the C2A domain of synaptotagmin IV cannot bind liposomes consisting of PS (or PI) and phosphatidylcholine, PC (or phosphatidylethanolamine, PE) (1:1, w/w), indicating that the binding to negatively charged phospholipids is inhibited by the presence of PC or PE. Phosphatidylcholines 99-118 synaptotagmin 4 Homo sapiens 31-47 8670105-7 1996 Calmodulin activates the enzyme 1.5-1.8-fold in the presence of phosphatidylcholine but not in the presence of phosphatidylserine. Phosphatidylcholines 64-83 calmodulin-3 Sus scrofa 0-10 8627336-0 1996 Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells. Phosphatidylcholines 106-125 hedgehog acyltransferase Homo sapiens 135-139 8613911-8 1996 Furthermore, PKC-mediated contraction may be augmented by additional diacylglycerol production arising from the hydrolysis of phosphatidylcholine by phosphatidylcholine-specific phospholipase C. Phosphatidylcholines 126-145 proline rich transmembrane protein 2 Homo sapiens 13-16 8613911-8 1996 Furthermore, PKC-mediated contraction may be augmented by additional diacylglycerol production arising from the hydrolysis of phosphatidylcholine by phosphatidylcholine-specific phospholipase C. Phosphatidylcholines 149-168 proline rich transmembrane protein 2 Homo sapiens 13-16 8627336-2 1996 In five clones with a less than fivefold increase in MARCKS protein level, the synthesis of PtdCho from [methyl-3H] choline was stimulated 1.88-2.34-fold in the presence of 100-200 nM TPA. Phosphatidylcholines 92-98 myristoylated alanine rich protein kinase C substrate Homo sapiens 53-59 8627336-2 1996 In five clones with a less than fivefold increase in MARCKS protein level, the synthesis of PtdCho from [methyl-3H] choline was stimulated 1.88-2.34-fold in the presence of 100-200 nM TPA. Phosphatidylcholines 92-98 plasminogen activator, tissue type Homo sapiens 184-187 8678916-10 1996 These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis. Phosphatidylcholines 45-64 angiotensinogen Rattus norvegicus 27-33 8743192-5 1996 However, the potentiating effect of HDL3 was completely blocked in the presence of the protein kinase C inhibitor, bisindoylmaleimide and the phosphatidylcholine-specific phospholipase C inhibitor, D609. Phosphatidylcholines 142-161 HDL3 Homo sapiens 36-40 8615772-0 1996 Regulation of phosphatidylcholine synthesis in maturing type II cells: increased mRNA stability of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 14-33 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 99-138 8615772-2 1996 This increase is accompanied by an increase in gene and protein expression of CTP:phosphocholine cytidylyltransferase (CT; EC 2.7.7.15), which catalyses a regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells. Phosphatidylcholines 182-201 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 78-117 8621399-7 1996 The C-terminal part of the 80-kDa protein (amino acids 597-737) is similar to sterol carrier protein 2 and facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes in vitro. Phosphatidylcholines 160-179 sterol carrier protein 2 Homo sapiens 78-102 8615695-2 1996 (R)-3-Hydroxybutyrate dehydrogenase (BDH; EC 1.1.1.30) is a lipid-requiring enzyme with a specific requirement of phosphatidylcholine for optimal function. Phosphatidylcholines 114-133 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 37-40 8615695-9 1996 These results suggest that the binding of BDH to the phosphatidylcholine head group is independent of its interaction with the apolar core of the phospholipid bilayer. Phosphatidylcholines 53-72 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 42-45 8723652-1 1996 Competitive binding of fluorescent probe 4-(n-dimethylaminostyryl)-1-methylpyiridinium n-toluenesulfonate and lysozyme to liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been investigated. Phosphatidylcholines 144-163 lysozyme Homo sapiens 110-118 8608156-3 1996 ApoA-IV bound to the surface of the microemulsion in equilibrium with a similar affinity to that of other helical apolipoproteins, and activated the transfer reaction by CETP of cholesteryl ester, triacylglycerol and phosphatidylcholine between the emulsions. Phosphatidylcholines 217-236 apolipoprotein A4 Homo sapiens 0-7 8670072-8 1996 Phosphatidylcholine also increased the basolateral secretion of apolipoprotein B (apoB) mass without altering apoB mRNA levels. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 64-80 8670072-8 1996 Phosphatidylcholine also increased the basolateral secretion of apolipoprotein B (apoB) mass without altering apoB mRNA levels. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 82-86 8670072-9 1996 Disruption of the Golgi apparatus by monensin or brefeldin A prevented the increase in apoB secretion by phosphatidylcholine. Phosphatidylcholines 105-124 apolipoprotein B Homo sapiens 87-91 8670072-10 1996 Compared with microsomes prepared from control cells, those from cells incubated with phosphatidylcholine contained more newly synthesized apoB. Phosphatidylcholines 86-105 apolipoprotein B Homo sapiens 139-143 8670072-12 1996 Thus in CaCo-2 cells incubated with phosphatidylcholine, the transport of apoB and triacylglycerols is increased whereas cholesteryl ester synthesis and secretion are decreased. Phosphatidylcholines 36-55 apolipoprotein B Homo sapiens 74-78 8678916-10 1996 These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis. Phosphatidylcholines 45-64 angiotensinogen Rattus norvegicus 212-218 8678916-1 1996 In the present study, we examined the effect of angiotensin II (Ang II) on phosphatidylcholine-hydrolyzing phospholipase D activity in subcultured rat aortic smooth muscle cells (SMC). Phosphatidylcholines 75-94 angiotensinogen Rattus norvegicus 48-62 8678916-10 1996 These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis. Phosphatidylcholines 270-289 angiotensinogen Rattus norvegicus 27-33 8678916-1 1996 In the present study, we examined the effect of angiotensin II (Ang II) on phosphatidylcholine-hydrolyzing phospholipase D activity in subcultured rat aortic smooth muscle cells (SMC). Phosphatidylcholines 75-94 angiotensinogen Rattus norvegicus 64-70 8678916-10 1996 These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis. Phosphatidylcholines 270-289 angiotensinogen Rattus norvegicus 212-218 8724608-7 1996 The presence in HETSR cells of p60-src whose synthesis is not controlled by dexamethasone may be responsible for increased phosphatidylcholine metabolism and sustaining cell growth under conditions of limited activity of growth-promoting compounds. Phosphatidylcholines 123-142 sequestosome 1 Homo sapiens 31-34 8597585-7 1996 Second, human and guinea pig LCAT were purified and used in phosphatidylcholine-reconstituted vesicles containing human apoAI to show their ability to esterify tritiated cholesterol, PREG, and DHEA in the absence of unlabeled steroid. Phosphatidylcholines 60-79 phosphatidylcholine-sterol acyltransferase Cavia porcellus 29-33 8597587-0 1996 Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions. Phosphatidylcholines 46-65 solute carrier family 38 member 5 Bos taurus 108-112 8612652-4 1996 Under these conditions, TNF-alpha induced the hydrolysis of PtdCho but did not promote the hydrolysis of 3H-labeled sphingomyelin, suggesting that the sphingomyelin signaling pool resides in a compartment distal to the Golgi apparatus, and possibly in the plasma membrane. Phosphatidylcholines 60-66 tumor necrosis factor Homo sapiens 24-33 8612652-6 1996 However, TNF caused PtdCho and sphingomyelin degradation in fibroblasts that had been treated with bacterial sphingomyelinase to degrade the sphingomyelin pool of the external leaflet of the plasma membrane. Phosphatidylcholines 20-26 tumor necrosis factor Homo sapiens 9-12 8612652-9 1996 In addition, when [3H]choline-labeled fibroblasts were treated under non-lytic conditions with bacterial phospholipase C to degrade the external pool of PtdCho, TNF was still able to stimulate the hydrolysis of PtdCho. Phosphatidylcholines 153-159 tumor necrosis factor Homo sapiens 161-164 8612652-9 1996 In addition, when [3H]choline-labeled fibroblasts were treated under non-lytic conditions with bacterial phospholipase C to degrade the external pool of PtdCho, TNF was still able to stimulate the hydrolysis of PtdCho. Phosphatidylcholines 211-217 tumor necrosis factor Homo sapiens 161-164 8728318-2 1996 We compared glycosylation structure, enzyme kinetics, and phosphatidylcholine (PC) acyl specificity of human LCAT from four sources: human plasma (pLCAT), media from HepG2 cells (HepG2 LCAT), media from SF21 cells infected with a recombinant baculovirus (bLCAT) and media from stably transfected Chinese hamster ovary (CHO) cells (CHO LCAT). Phosphatidylcholines 58-77 lecithin-cholesterol acyltransferase Homo sapiens 109-113 8868466-6 1996 Small unilamellar phosphatidyl choline:cholesterol vesicles loaded with FGF-2 increased uPA production in GM 7373 cells in the absence of a mitogenic response. Phosphatidylcholines 18-38 fibroblast growth factor 2 Bos taurus 72-77 8868466-6 1996 Small unilamellar phosphatidyl choline:cholesterol vesicles loaded with FGF-2 increased uPA production in GM 7373 cells in the absence of a mitogenic response. Phosphatidylcholines 18-38 plasminogen activator, urokinase Bos taurus 88-91 8867924-7 1996 fMLP, but not tBuBHQ, caused BAPTA/AM-sensitive activation of phospholipase A2 and D. tBuBHQ caused O2- production by interacting with phosphatidylcholine in a cell-free system. Phosphatidylcholines 135-154 formyl peptide receptor 1 Homo sapiens 0-4 8867924-7 1996 fMLP, but not tBuBHQ, caused BAPTA/AM-sensitive activation of phospholipase A2 and D. tBuBHQ caused O2- production by interacting with phosphatidylcholine in a cell-free system. Phosphatidylcholines 135-154 phospholipase A2 group IB Homo sapiens 62-78 8611143-2 1996 Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane. Phosphatidylcholines 60-79 protein kinase C, alpha Rattus norvegicus 185-194 8576189-2 1996 We have named this open reading frame, PLD1, and show that yeast bearing a disruption in this gene are unable to catalyze the hydrolysis of phosphatidylcholine. Phosphatidylcholines 140-159 phospholipase D Saccharomyces cerevisiae S288C 39-43 8576189-7 1996 This is the first identification of a eukaryotic, nonplant, phosphatidylcholine-hydrolyzing phospholipase D gene. Phosphatidylcholines 60-79 phospholipase D Saccharomyces cerevisiae S288C 92-107 8611143-2 1996 Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane. Phosphatidylcholines 81-83 protein kinase C, alpha Rattus norvegicus 185-194 8576263-5 1996 We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 106-125 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 127-166 8576263-5 1996 We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 106-125 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 176-220 8576263-5 1996 We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 106-125 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 222-226 8576263-9 1996 The labeling of phosphatidylcholine in isolated hepatocytes from CD rats was consistent with the conversion of PE to PC being increased as a result of a higher expression of liver PEMT. Phosphatidylcholines 16-35 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 180-184 8611143-2 1996 Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane. Phosphatidylcholines 81-83 protein kinase C, beta Rattus norvegicus 199-207 8611143-2 1996 Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane. Phosphatidylcholines 60-79 protein kinase C, beta Rattus norvegicus 199-207 8611148-13 1996 Phosphatidylcholine (and its structural analogue sphingomyelin) were the best lipid activators of Cpt1p, the main biologically relevant CPT activity in S. cerevisiae. Phosphatidylcholines 0-19 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 98-103 8882734-4 1996 Similar immunogenicity was displayed by free Gfpt1 in muramyldipeptide-phosphoethanolamine-containing phosphatidyl-choline, -serine (PC,PS) liposomes. Phosphatidylcholines 102-122 glutamine fructose-6-phosphate transaminase 1 Mus musculus 45-50 8850316-1 1996 After the administration of the recombinant human tumor necrosis factor (rHuTNF), plasma concentration could be controlled from egg yolk phosphatidylcholine (eggPC)-egg yolk phosphatidic acid (eggPA) liposome (EggPA liposome). Phosphatidylcholines 137-156 tumor necrosis factor Homo sapiens 50-71 8770209-0 1996 Calorimetry of apolipoprotein-A1 binding to phosphatidylcholine-triolein-cholesterol emulsions. Phosphatidylcholines 44-63 apolipoprotein A1 Homo sapiens 15-32 9386267-2 1996 PEMT catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in hepatocytes. Phosphatidylcholines 61-80 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-4 8770209-17 1996 This value indicates that apo-A1 binding to a fluid surface like egg yolk phosphatidylcholine or probably DPPC at 45 degrees C is hydrophobic and is consistent with hydrocarbon lipid or protein moities coming together and excluding water. Phosphatidylcholines 74-93 apolipoprotein A1 Homo sapiens 26-32 9034754-2 1996 Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner. Phosphatidylcholines 12-31 heparan sulfate proteoglycan 2 Homo sapiens 66-69 9034754-2 1996 Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner. Phosphatidylcholines 33-35 heparan sulfate proteoglycan 2 Homo sapiens 66-69 11725084-4 1996 A cellular phospholipase A(2) with an arachidonyl specificity at the sn-2 position of phosphatidylcholine, which required submicromolar calcium, was identified as a cytosolic phospholipase A(2) by immunoblot analysis. Phosphatidylcholines 86-105 LOC104974671 Bos taurus 11-28 11725084-4 1996 A cellular phospholipase A(2) with an arachidonyl specificity at the sn-2 position of phosphatidylcholine, which required submicromolar calcium, was identified as a cytosolic phospholipase A(2) by immunoblot analysis. Phosphatidylcholines 86-105 LOC104974671 Bos taurus 175-192 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-36 8820101-7 1996 The epitope of this antibody resides in oxidized products of phosphatidylcholine that can form complexes with polypeptides, including apolipoprotein B. Phosphatidylcholines 61-80 apolipoprotein B Homo sapiens 134-150 8820107-0 1996 Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates. Phosphatidylcholines 122-141 lecithin-cholesterol acyltransferase Canis lupus familiaris 52-88 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidylcholines 73-92 formyl peptide receptor 1 Homo sapiens 121-125 8554602-1 1995 Lysophosphatidylcholine (LysoPC), which is formed by phospholipase A2 (PLA2)-mediated phosphatidylcholine hydrolysis, is involved in enhancement of the diacylglycerol- or phorbol ester-dependent protein kinase C (PKC) activation. Phosphatidylcholines 4-23 phospholipase A2 group IB Rattus norvegicus 53-69 8554602-1 1995 Lysophosphatidylcholine (LysoPC), which is formed by phospholipase A2 (PLA2)-mediated phosphatidylcholine hydrolysis, is involved in enhancement of the diacylglycerol- or phorbol ester-dependent protein kinase C (PKC) activation. Phosphatidylcholines 4-23 phospholipase A2 group IB Rattus norvegicus 71-75 8618893-2 1995 When assayed by measuring the phosphatidyl transfer reaction to ethanol with exogenously added radioactive phosphatidylcholine as substrate, the PLD required a high concentration (1.6 M) of ammonium sulfate to exhibit high enzymatic activity. Phosphatidylcholines 107-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 145-148 8541336-0 1995 The enhancement of phosphatidylcholine biosynthesis by angiotensin II in H9c2 cells. Phosphatidylcholines 19-38 angiotensinogen Rattus norvegicus 55-69 8554325-6 1995 The lipid which tended to be associated with rhodopsin in protein-lipid-detergent mixed micelles was also consistently richer in PC than that present in lipid-detergent micelles. Phosphatidylcholines 129-131 rhodopsin Bos taurus 45-54 8530346-1 1995 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-58 8530346-1 1995 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 8530346-3 1995 Characterization of recombinant human PLD1 reveals that it is membrane-associated, selective for phosphatidylcholine, stimulated by phosphatidylinositol 4,5-bisphosphate, activated by the monomeric G-protein ADP-ribosylation factor-1, and inhibited by oleate. Phosphatidylcholines 97-116 phospholipase D1 Homo sapiens 38-42 8541336-1 1995 The effect of angiotensin II on the biosynthesis of phosphatidylcholine in rat heart myoblastic (H9c2) cells was investigated. Phosphatidylcholines 52-71 angiotensinogen Rattus norvegicus 14-28 8541336-3 1995 When cells were pretreated with angiotensin II, a significant increase in the labelling of phosphatidylcholine was observed. Phosphatidylcholines 91-110 angiotensinogen Rattus norvegicus 32-46 8541336-4 1995 Analysis of the labelled phosphatidylcholine precursors indicated that the conversion of phosphocholine to CDP-choline was enhanced by angiotensin II treatment. Phosphatidylcholines 25-44 angiotensinogen Rattus norvegicus 135-149 8541336-9 1995 We conclude that the increase in phosphatidylcholine biosynthesis by angiotensin II was a direct result of the enhancement of the cytidylyltransferase activity. Phosphatidylcholines 33-52 angiotensinogen Rattus norvegicus 69-83 8846779-0 1995 Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. Phosphatidylcholines 88-107 Fas cell surface death receptor Homo sapiens 39-44 11854811-5 1995 We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 102-121 taxilin alpha Homo sapiens 17-22 11854811-5 1995 We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 102-121 phospholipase A2 group IB Homo sapiens 31-49 11854811-5 1995 We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 102-121 phospholipase A2 group IB Homo sapiens 51-57 7498535-3 1995 At physiological ionic strength (130 mM KCl) ezrin interacts strongly with liposomes containing > or = 5% phosphatidylinositol-4,5-bisphosphate (PIP2), the residual being phosphatidylcholine (PC). Phosphatidylcholines 174-193 ezrin Homo sapiens 45-50 7498535-3 1995 At physiological ionic strength (130 mM KCl) ezrin interacts strongly with liposomes containing > or = 5% phosphatidylinositol-4,5-bisphosphate (PIP2), the residual being phosphatidylcholine (PC). Phosphatidylcholines 195-197 ezrin Homo sapiens 45-50 7492275-7 1995 RESULTS: The incorporation of 14C-labeled glucose (D-[U-14C]glucose) into phosphatidylcholine and phosphatidylglycerol was selectively inhibited either by 8-Br-cGMP or in the presence of TNF-alpha, PGE2, or nitroprusside, all of which caused an increase in the intracellular levels of cGMP. Phosphatidylcholines 74-93 tumor necrosis factor Homo sapiens 187-196 7492275-14 1995 CONCLUSIONS: The NO generation, secondary to PGE2 production, seems responsible for the TNF-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes. Phosphatidylcholines 120-139 tumor necrosis factor Homo sapiens 88-97 8846779-0 1995 Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. Phosphatidylcholines 88-107 Fas cell surface death receptor Homo sapiens 46-50 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 sphingomyelin phosphodiesterase 1 Homo sapiens 138-161 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 sphingomyelin phosphodiesterase 1 Homo sapiens 163-169 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 Fas cell surface death receptor Homo sapiens 223-228 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 sphingomyelin phosphodiesterase 1 Homo sapiens 237-243 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 Fas cell surface death receptor Homo sapiens 268-273 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 sphingomyelin phosphodiesterase 2 Homo sapiens 282-306 8846779-3 1995 Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation. Phosphatidylcholines 16-35 sphingomyelin phosphodiesterase 2 Homo sapiens 308-314 8653540-3 1995 Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL. Phosphatidylcholines 12-31 lipase E, hormone sensitive type Rattus norvegicus 106-109 8547181-4 1995 In addition, a purified recombinant peptide derived from the SCP2-related domain of the 17 beta-HSD type IV has about 30% of the transfer activities for 7-dehydrocholesterol and phosphatidylcholine seen with purified recombinant human SCP2. Phosphatidylcholines 178-197 sterol carrier protein 2 Homo sapiens 61-65 8789601-6 1995 We investigated whether expression of specific PKC isoforms might correlate with these effects of phorbol esters on PtdCho synthesis. Phosphatidylcholines 116-122 protein kinase C alpha Homo sapiens 47-50 8653540-4 1995 These results suggest that the active HSL is already present in the fat cell even in the absence of lipolytic hormone, and phosphatidylcholine on the surface of endogenous lipid droplets causes inhibition toward lipolytic action of HSL. Phosphatidylcholines 123-142 lipase E, hormone sensitive type Rattus norvegicus 232-235 8789601-13 1995 Accordingly, stimulation of PtdCho turnover by phorbol esters correlated only with expression of PKC-alpha; presence of PKC-beta alone was insufficient for a TPA response. Phosphatidylcholines 28-34 protein kinase C alpha Homo sapiens 97-106 8584016-7 1995 Alternatively, the labelled choline produced by vasopressin stimulation was released into the medium, thus reducing the recycling of label precursor back into the phospholipid and making the decrease in the labelling of phosphatidylcholine readily detectable. Phosphatidylcholines 220-239 arginine vasopressin Rattus norvegicus 48-59 8600835-2 1995 Phosphatidylcholines containing an arachidonyl chain at the sn-2 position and either a 10-pyrenedecyl or a 10-pyrenedecanoyl chain at the sn-1 position were synthesized and shown to be substrates for cPLA2 in a fluorescence-based assay. Phosphatidylcholines 0-20 phospholipase A2 group IVA Homo sapiens 200-205 7577961-2 1995 Prothrombinase was assembled at a macroscopic phospholipid membrane, composed of 25 mol % phosphatidylserine and 75 mol % phosphatidylcholine, deposited on the inner wall of a glass capillary, by perfusion with a factor Xa-factor Va mixture. Phosphatidylcholines 122-141 coagulation factor X Homo sapiens 0-14 7577962-3 1995 Therefore, the effect of K+ concentration on the ability of MBP to aggregate large unilamellar vesicles (LUVs) containing phosphatidylcholine (PC) and 10-20% acidic lipid was investigated. Phosphatidylcholines 122-141 myelin basic protein Homo sapiens 60-63 7577962-3 1995 Therefore, the effect of K+ concentration on the ability of MBP to aggregate large unilamellar vesicles (LUVs) containing phosphatidylcholine (PC) and 10-20% acidic lipid was investigated. Phosphatidylcholines 143-145 myelin basic protein Homo sapiens 60-63 8584016-5 1995 When the cells were pulse labelled with [3H]-choline, vasopressin stimulation caused a decrease in the labelled phosphatidylcholine with a corresponding increase in the labelled choline. Phosphatidylcholines 112-131 arginine vasopressin Rattus norvegicus 54-65 8618786-1 1995 CTP:phosphocholine cytidylyltransferase (CT) catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine (PC). Phosphatidylcholines 117-136 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 8618786-1 1995 CTP:phosphocholine cytidylyltransferase (CT) catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine (PC). Phosphatidylcholines 138-140 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 7499345-8 1995 Similar to microsomal RoDH and RoDH(I), RoDH(II) had higher activity with NADP rather than NAD, was stimulated by ethanol and phosphatidyl choline, was not inhibited by the medium-chain alcohol dehydrogenase inhibitor 4-methylpyrazole, but was inhibited by phenylarsine oxide and the short-chain dehydrogenase/reductase inhibitor carbenoxolone. Phosphatidylcholines 126-146 retinol dehydrogenase 7 Rattus norvegicus 31-38 7499345-8 1995 Similar to microsomal RoDH and RoDH(I), RoDH(II) had higher activity with NADP rather than NAD, was stimulated by ethanol and phosphatidyl choline, was not inhibited by the medium-chain alcohol dehydrogenase inhibitor 4-methylpyrazole, but was inhibited by phenylarsine oxide and the short-chain dehydrogenase/reductase inhibitor carbenoxolone. Phosphatidylcholines 126-146 retinol dehydrogenase 16 Rattus norvegicus 40-48 7487093-1 1995 The effects of expression of the H-ras oncogene on phosphatidylcholine metabolism were examined in C3H10T1/2 and NIH3T3 cells expressing ras constitutively or under the control of inducible promoters. Phosphatidylcholines 51-70 Harvey rat sarcoma virus oncogene Mus musculus 33-38 7583579-2 1995 HDL3 elicited phosphatidylcholine (PC) and phosphatidylinositol (PI) turnover and activated multiple phospholipases. Phosphatidylcholines 14-33 HDL3 Homo sapiens 0-4 7583579-2 1995 HDL3 elicited phosphatidylcholine (PC) and phosphatidylinositol (PI) turnover and activated multiple phospholipases. Phosphatidylcholines 35-37 HDL3 Homo sapiens 0-4 7583579-3 1995 In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol. Phosphatidylcholines 13-15 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 8593248-0 1995 Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29). Phosphatidylcholines 0-19 epidermal growth factor Homo sapiens 87-90 8593248-3 1995 ), we have shown that epidermal growth factor (EGF) increased protein kinase C (PKC) activities in colon carcinoma cell line (HT29), possibly through the increased 1,2-diacylglycerol (1,2-DAG) production via phosphatidylcholine (PC). Phosphatidylcholines 208-227 epidermal growth factor Homo sapiens 22-51 8593248-3 1995 ), we have shown that epidermal growth factor (EGF) increased protein kinase C (PKC) activities in colon carcinoma cell line (HT29), possibly through the increased 1,2-diacylglycerol (1,2-DAG) production via phosphatidylcholine (PC). Phosphatidylcholines 229-231 epidermal growth factor Homo sapiens 22-51 8593248-4 1995 Here we investigate the effect of well-known PKC activator 12-O-tetradecanoyl-2 phorbol-13-acetate (TPA), on the levels of 32P incorporation into EGF induced phosphatidylinositols (PI, PI4P, PI4, 5P2) and different phospholipids (PC, PA, PS) as well as on induced tyrosine kinase activity. Phosphatidylcholines 230-232 epidermal growth factor Homo sapiens 146-149 8593248-5 1995 TPA significantly decreased the effects of EGF and it had the biggest inhibitory effect on EGF induced PC level. Phosphatidylcholines 103-105 epidermal growth factor Homo sapiens 91-94 8593248-6 1995 These data support our contention that PC plays an important role in the activation of PKC via 1,2-DAG production in the EGF stimulated pathway. Phosphatidylcholines 39-41 epidermal growth factor Homo sapiens 121-124 7475000-1 1995 Reconstituted high-density lipoprotein (rHDL), an artificial lipoprotein consisting of apolipoprotein A-I and phosphatidylcholine (1:150, molar ratios) dose-dependently reduces lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF) production in in vitro, ex-vivo, and in-vivo model systems. Phosphatidylcholines 110-129 tumor necrosis factor Oryctolagus cuniculus 210-237 7475000-1 1995 Reconstituted high-density lipoprotein (rHDL), an artificial lipoprotein consisting of apolipoprotein A-I and phosphatidylcholine (1:150, molar ratios) dose-dependently reduces lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF) production in in vitro, ex-vivo, and in-vivo model systems. Phosphatidylcholines 110-129 tumor necrosis factor Oryctolagus cuniculus 239-242 8788774-1 1995 The influence of chronic administration of cytidine-5"-diphosphate choline (CDP-choline), a precursor of the membrane lipid phosphatidylcholine, was studied in neurosecretory neurons (NSNs) of the supraoptic nucleus (SON) of aged mouse hypothalamus. Phosphatidylcholines 124-143 cut-like homeobox 1 Mus musculus 76-79 7577962-7 1995 Concentrations of K+ above 150 mM caused dissociation of MBP from LUVs containing PC and a single acidic lipid. Phosphatidylcholines 82-84 myelin basic protein Homo sapiens 57-60 7487907-0 1995 Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol. Phosphatidylcholines 22-41 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 178-181 7487907-0 1995 Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol. Phosphatidylcholines 135-154 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 178-181 7487907-0 1995 Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol. Phosphatidylcholines 156-162 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 178-181 7487907-6 1995 Ionomycin, a Ca2+ ionophore, induced PtdCho hydrolysis to a greater extent than bradykinin, also in an extracellular-Ca(2+)-dependent manner. Phosphatidylcholines 37-43 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 13-16 7592669-2 1995 We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells. Phosphatidylcholines 93-112 tumor necrosis factor Homo sapiens 38-47 7592669-2 1995 We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells. Phosphatidylcholines 93-112 interleukin 1 beta Homo sapiens 52-61 8825031-3 1995 Phosphatidylcholines with short (C14) or long (C24) fatty acyl chains have marked effects on the activity of the ATPase, including a change in the stoichiometry of Ca binding. Phosphatidylcholines 0-20 dynein axonemal heavy chain 8 Homo sapiens 113-119 8640350-0 1995 Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells. Phosphatidylcholines 19-38 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 8640350-17 1995 These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-102 8640350-17 1995 These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-102 8575813-2 1995 The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline. Phosphatidylcholines 129-149 lecithin cholesterol acyltransferase Rattus norvegicus 11-48 8575813-2 1995 The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline. Phosphatidylcholines 129-149 lecithin cholesterol acyltransferase Rattus norvegicus 50-54 8576100-5 1995 On the other hand, liposomes composed of phosphatidylcholine (PC) showed no increase in permeability when incubated with IL-1 alpha, suggesting the importance of acidic phospholipids in the interaction of IL-1 alpha with the membrane. Phosphatidylcholines 41-60 interleukin 1 alpha Homo sapiens 205-215 8564710-3 1995 Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system. Phosphatidylcholines 104-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 8564710-3 1995 Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system. Phosphatidylcholines 125-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 8590265-4 1995 An arachidonoyl-dependent phospholipase A2 is activated to release arachidonic acid from membrane phospholipids, especially phosphatidylcholine and ethanolamine. Phosphatidylcholines 124-143 phospholipase A2 Oryctolagus cuniculus 26-42 8709678-1 1995 Cytidine 5"-diphosphocholine, CDP-choline or citicoline, is an essential intermediate in the biosynthetic pathway of the structural phospholipids of cell membranes, especially in that of phosphatidylcholine. Phosphatidylcholines 187-206 natriuretic peptide A Homo sapiens 30-33 8538377-4 1995 While both L-FABP and I-FABP increased esterification of [3H]-oleic acid into ethanolamine glycerophospholipids, these proteins had opposite effect on esterification into choline glycerophospholipids. Phosphatidylcholines 171-199 fatty acid binding protein 1, liver Mus musculus 11-17 8538377-4 1995 While both L-FABP and I-FABP increased esterification of [3H]-oleic acid into ethanolamine glycerophospholipids, these proteins had opposite effect on esterification into choline glycerophospholipids. Phosphatidylcholines 171-199 fatty acid binding protein 2, intestinal Mus musculus 22-28 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 146-165 phospholipase A2 group IB Homo sapiens 23-39 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 146-165 phospholipase A2 group IB Homo sapiens 41-45 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 167-169 phospholipase A2 group IB Homo sapiens 23-39 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 167-169 phospholipase A2 group IB Homo sapiens 41-45 7559399-0 1995 Phosphatidylcholines with sn-1 saturated and sn-2 cis-monounsaturated acyl chains. Phosphatidylcholines 0-20 solute carrier family 38 member 3 Homo sapiens 26-30 8578536-10 1995 Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 95-114 phospholipase A2 group IB Homo sapiens 9-13 7559399-12 1995 In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart. Phosphatidylcholines 112-131 solute carrier family 38 member 3 Homo sapiens 72-76 8578536-10 1995 Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. Phosphatidylcholines 116-118 phospholipase A2 group IB Homo sapiens 9-13 7559399-12 1995 In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart. Phosphatidylcholines 112-131 solute carrier family 38 member 5 Homo sapiens 87-91 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 193-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 7559399-12 1995 In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart. Phosphatidylcholines 112-131 solute carrier family 38 member 5 Homo sapiens 180-184 7673165-6 1995 These results clearly implicate both Raf-1 and zeta PKC as necessary downstream components for transduction of the mitogenic/oncogenic signal generated by PLC-mediated hydrolysis of phosphatidylcholine and suggest, together with other recent evidence, a bifurcation in the signaling pathway downstream of PC-PLC. Phosphatidylcholines 182-201 v-raf-leukemia viral oncogene 1 Mus musculus 37-55 7673165-6 1995 These results clearly implicate both Raf-1 and zeta PKC as necessary downstream components for transduction of the mitogenic/oncogenic signal generated by PLC-mediated hydrolysis of phosphatidylcholine and suggest, together with other recent evidence, a bifurcation in the signaling pathway downstream of PC-PLC. Phosphatidylcholines 182-201 perlecan (heparan sulfate proteoglycan 2) Mus musculus 155-158 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 193-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 214-220 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 214-220 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 7654192-0 1995 Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry. Phosphatidylcholines 83-102 cytochrome c oxidase subunit 8A Homo sapiens 36-40 7654206-4 1995 As observed for PI-TP alpha, PI-TP beta has a distinct preference for phosphatidylinositol over phosphatidylcholine. Phosphatidylcholines 96-115 phosphatidylinositol transfer protein beta Bos taurus 29-39 8519996-6 1995 The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation. Phosphatidylcholines 191-210 proline rich transmembrane protein 2 Homo sapiens 95-111 8519996-6 1995 The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation. Phosphatidylcholines 191-210 proline rich transmembrane protein 2 Homo sapiens 113-117 7650054-8 1995 Moreover, we have demonstrated that the extracellular Ca(2+)-dependent increase in diacylglycerol levels in response to EGF is associated with an increase in extracellular choline release, which is indicative of an activation of a phosphatidylcholine-linked phospholipase D. These results suggest that diacylglycerol sources other than PtdIns"s may be important in the extracellular Ca(2+)-dependent regulation of EGF-mediated cell replication. Phosphatidylcholines 231-250 epidermal growth factor Homo sapiens 120-123 8519996-6 1995 The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation. Phosphatidylcholines 191-210 proline rich transmembrane protein 2 Homo sapiens 282-286 7657619-6 1995 This was verified by demonstrating that the phospholipids, phosphatidylcholine and phosphatidylinositol, were hydrolyzed to glycerophosphocholine and glycerophosphoinositol by incubation with recombinant 85-kDa PLA2. Phosphatidylcholines 59-78 phospholipase A2, group IB, pancreas Mus musculus 211-215 7544643-8 1995 These antibodies also inhibited the binding of fVIII to synthetic phospholipid membranes of PS and phosphatidylcholine, confirming that the blocked epitopes contribute to membrane binding as well as binding to PS. Phosphatidylcholines 99-118 coagulation factor VIII Homo sapiens 47-52 7650054-8 1995 Moreover, we have demonstrated that the extracellular Ca(2+)-dependent increase in diacylglycerol levels in response to EGF is associated with an increase in extracellular choline release, which is indicative of an activation of a phosphatidylcholine-linked phospholipase D. These results suggest that diacylglycerol sources other than PtdIns"s may be important in the extracellular Ca(2+)-dependent regulation of EGF-mediated cell replication. Phosphatidylcholines 231-250 epidermal growth factor Homo sapiens 414-417 7545008-9 1995 At a given lipase concentration in the water subphase, the interfacial binding of HGL to the nonhydrolyzable egg yolk phosphatidylcholine (egg PC) monolayers was found to be 10 times lower than that in the case of dicaprin monolayers. Phosphatidylcholines 118-137 lipase F, gastric type Homo sapiens 82-85 7480083-4 1995 The major long-chain polyunsaturated fatty acids (LC-PUFA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are found primarily in PC, PE, and PI. Phosphatidylcholines 167-169 pumilio RNA binding family member 3 Homo sapiens 53-57 7650001-4 1995 The partition coefficient, Kp, describing the affinity of myristoylated MRP for acidic lipid vesicles (20% phosphatidylserine, 80% phosphatidylcholine) is 5-8 x 10(3) M-1, which is only 2-4 times larger than the partition coefficient for the unmyristoylated protein. Phosphatidylcholines 131-150 MARCKS-like 1 Mus musculus 72-75 7650001-9 1995 Since only a marginal binding could be observed with neutral phosphatidylcholine vesicles, we propose that electrostatic interactions are the major determinant of the binding of MRP to pure lipid membranes. Phosphatidylcholines 61-80 MARCKS-like 1 Mus musculus 178-181 8588979-4 1995 This suggests that a synergistic involvement of phosphatidylinositol-bis-phosphate (PIP2) hydrolysis and phosphatidylcholine (PC) breakdown provide early molecular events upon the interaction between interferon beta and its cell surface receptors. Phosphatidylcholines 105-124 interferon beta 1 Homo sapiens 200-215 8562872-4 1995 The activity of the phospholipid-free, detergent-solubilized enzyme was almost fully restored by phosphatidyl serine (PS) and its sensitivity to calmodulin was restored in the presence of phosphatidyl choline (PC). Phosphatidylcholines 188-208 calmodulin 1 Homo sapiens 145-155 8562872-4 1995 The activity of the phospholipid-free, detergent-solubilized enzyme was almost fully restored by phosphatidyl serine (PS) and its sensitivity to calmodulin was restored in the presence of phosphatidyl choline (PC). Phosphatidylcholines 210-212 calmodulin 1 Homo sapiens 145-155 8588979-4 1995 This suggests that a synergistic involvement of phosphatidylinositol-bis-phosphate (PIP2) hydrolysis and phosphatidylcholine (PC) breakdown provide early molecular events upon the interaction between interferon beta and its cell surface receptors. Phosphatidylcholines 126-128 interferon beta 1 Homo sapiens 200-215 7616250-6 1995 When the oral CDP-choline treatment was prolonged for 42 and 90 days, brain phosphatidylcholine concentrations increased significantly (by 22-25%; p < 0.05) in rats consuming 500 mg/kg/day. Phosphatidylcholines 76-95 cut-like homeobox 1 Rattus norvegicus 14-17 7579706-4 1995 Also, phospholipase D activity, estimated by the production of phosphatidylethanol from phosphatidylcholine in the presence of ethanol, was stimulated by GnRH but not ET-1. Phosphatidylcholines 88-107 gonadotropin releasing hormone 1 Homo sapiens 154-158 7477743-3 1995 Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis. Phosphatidylcholines 143-162 cut like homeobox 1 Homo sapiens 28-31 7481876-5 1995 Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding. Phosphatidylcholines 167-186 phospholipase A2 group IB Rattus norvegicus 56-72 7481876-5 1995 Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding. Phosphatidylcholines 188-190 phospholipase A2 group IB Rattus norvegicus 56-72 7551686-3 1995 Plasma phospholipids demonstrated three distinct PAF inhibitory fractions in TLC regions corresponding to those of sphingomyelin, phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 130-149 PCNA clamp associated factor Homo sapiens 49-52 7542869-3 1995 We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates. Phosphatidylcholines 151-170 serum amyloid A1 Homo sapiens 35-38 7542869-3 1995 We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates. Phosphatidylcholines 151-170 phospholipase A2 group X Homo sapiens 115-120 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 126-145 interleukin 1 alpha Mus musculus 0-19 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 126-145 interleukin 1 alpha Mus musculus 21-30 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 126-145 tumor necrosis factor Mus musculus 36-63 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 126-145 tumor necrosis factor Mus musculus 65-74 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 147-149 interleukin 1 alpha Mus musculus 0-19 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 147-149 interleukin 1 alpha Mus musculus 21-30 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 147-149 tumor necrosis factor Mus musculus 36-63 7606887-1 1995 Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer. Phosphatidylcholines 147-149 tumor necrosis factor Mus musculus 65-74 7615839-3 1995 With fibroblasts from normal subjects, purified apo A-I cleared cells of cholesteryl esters, depleted cellular free cholesterol pools available for esterification, and stimulated efflux of radiolabeled cholesterol, phosphatidylcholine, and sphingomyelin. Phosphatidylcholines 215-234 apolipoprotein A1 Homo sapiens 48-55 7631805-9 1995 This form of PLA2 exhibited a neutral and broad pH optimum (pH 6.0-8.0) and hydrolyzed both phosphatidylethanolamine and phosphatidylcholine effectively. Phosphatidylcholines 121-140 phospholipase A2 group IB Homo sapiens 13-17 8537301-3 1995 We found that at neutral pH and low ionic strength, beta 2-GPI became bound to liposome membranes containing cardiolipin, phosphatidylglycerol, phosphatidylserine, phosphatidylserine, phosphatidic acid, or phosphatidylinositol, but not phosphatidylcholine alone. Phosphatidylcholines 236-255 apolipoprotein H Bos taurus 52-62 7551690-5 1995 Codispersion with the semi-synthetic phosphatidylcholine of cholesterol or unsaturated fluid lecithin modulated both excimer formation and the susceptibility of the fluorescent probe to hydrolysis by venom phospholipase A2 at 22 degrees C. Similar results were obtained with hydrolysis of a radiolabelled substrate, 1-palmitoyl-sn-2-[1-14C]linoleoylphosphatidylethanolamine, codispersed with the semi-synthetic phosphatidylcholine. Phosphatidylcholines 411-430 phospholipase A2 group IB Rattus norvegicus 206-222 7551690-5 1995 Codispersion with the semi-synthetic phosphatidylcholine of cholesterol or unsaturated fluid lecithin modulated both excimer formation and the susceptibility of the fluorescent probe to hydrolysis by venom phospholipase A2 at 22 degrees C. Similar results were obtained with hydrolysis of a radiolabelled substrate, 1-palmitoyl-sn-2-[1-14C]linoleoylphosphatidylethanolamine, codispersed with the semi-synthetic phosphatidylcholine. Phosphatidylcholines 37-56 phospholipase A2 group IB Rattus norvegicus 206-222 8524695-6 1995 Decreased phosphatidylethanolamine, phosphatidylinositol and phosphatidylcholine levels were shown in patients before EPO treatment, compares with the control group. Phosphatidylcholines 61-80 erythropoietin Homo sapiens 118-121 7564919-4 1995 We find that both GM-CSF and SLF induced increased phosphatidylcholine (PC) turnover rates (biosynthesis and degradation) as measured by increased [3H]-choline labelling, with SLF being more potent than GM-CSF after 6 h of stimulation, but equipotent at 24 h of stimulation. Phosphatidylcholines 51-70 colony stimulating factor 2 Homo sapiens 18-24 7564919-4 1995 We find that both GM-CSF and SLF induced increased phosphatidylcholine (PC) turnover rates (biosynthesis and degradation) as measured by increased [3H]-choline labelling, with SLF being more potent than GM-CSF after 6 h of stimulation, but equipotent at 24 h of stimulation. Phosphatidylcholines 51-70 KIT ligand Homo sapiens 29-32 7794891-8 1995 Thus, cPLA2 has phospholipase A1 activity but only if an ether linkage rather than an ester linkage is present at the sn-2 position, and it is shown that the sn-1 acyl chains of both enantiomers of phosphatidylcholine are hydrolyzed. Phosphatidylcholines 198-217 phospholipase A2 group IVA Homo sapiens 6-11 7768909-3 1995 The chemotactic peptide fMLP and the phorbol ester, phorbol 12-myristate 13-acetate, are known to stimulate phosphatidylcholine degradation by phospholipase D in human neutrophils. Phosphatidylcholines 108-127 formyl peptide receptor 1 Homo sapiens 24-28 7794891-1 1995 The recombinant human 85-kDa cytosolic phospholipase A2 (cPLA2), when assayed in the presence of glycerol, catalyzes the transfer of acyl chains of radiolabeled phosphatidylcholine and para-substituted phenyl esters of fatty acids to glycerol, in addition to hydrolyzing these substrates. Phosphatidylcholines 161-180 phospholipase A2 group IVA Homo sapiens 57-62 7768909-4 1995 fMLP alone triggered phosphatidylcholine breakdown into phosphatidic acid, but did not stimulate phosphatidylcholine synthesis or activation of the rate-limiting enzyme CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 21-40 formyl peptide receptor 1 Homo sapiens 0-4 7768909-5 1995 Adding cytochalasin B to fMLP led to some conversion of phosphatidic acid into diglyceride, and fMLP was then able to trigger choline incorporation into phosphatidylcholine, and cytidylyltransferase translocation from cytosol to membranes. Phosphatidylcholines 153-172 formyl peptide receptor 1 Homo sapiens 96-100 7626201-0 1995 Transmembrane Ca2+ gradient-mediated phosphatidylcholine modulating sarcoplasmic reticulum C(a2+)-ATPase. Phosphatidylcholines 37-56 dynein axonemal heavy chain 8 Homo sapiens 98-104 7772034-4 1995 The presence of certain membrane-bound anions can enhance hydrolysis of PC by the mammalian secreted PLA2S. Phosphatidylcholines 72-74 phospholipase A2 group IIA Homo sapiens 101-106 7647244-1 1995 Solid-state 2H nuclear magnetic resonance spectroscopy was used to determine the orientational order parameter profiles for a series of phosphatidylcholines with perdeuterated stearic acid, 18:0d35, in position sn-1 and 18:1 omega 9, 18:2 omega 6, 18:3 omega 3, 20:4 omega 6, 20:5 omega 3, or 22:6 omega 3 in position sn-2. Phosphatidylcholines 136-156 solute carrier family 38 member 3 Homo sapiens 211-288 7626201-2 1995 The role of phospholipids, especially phosphatidylcholine (PC), in the modulation of C(a2+)-ATPase by transmembrane Ca2+ gradient was investigated. Phosphatidylcholines 59-61 dynein axonemal heavy chain 8 Homo sapiens 92-98 7626201-4 1995 (i) Incubated with phospholipids, the enzyme activity of the delipidated C(a2+)-ATPase is inhibited by Ca2+ and the highest inhibition is observed in the presence of PC. Phosphatidylcholines 166-168 dynein axonemal heavy chain 8 Homo sapiens 80-86 7744831-1 1995 In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I. Phosphatidylcholines 196-216 lecithin-cholesterol acyltransferase Homo sapiens 22-58 7744831-1 1995 In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I. Phosphatidylcholines 196-216 lecithin-cholesterol acyltransferase Homo sapiens 60-64 7744831-5 1995 When DBP preparations containing 27-hydroxycholesterol and various phosphatidylcholines were used for the LCAT reaction, both monoesters and diesters were produced. Phosphatidylcholines 67-87 lecithin-cholesterol acyltransferase Homo sapiens 106-110 7758577-2 1995 Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho). Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 7758577-2 1995 Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho). Phosphatidylcholines 101-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 7758586-1 1995 Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF. Phosphatidylcholines 12-31 nerve growth factor Homo sapiens 117-136 7758586-1 1995 Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF. Phosphatidylcholines 12-31 nerve growth factor Homo sapiens 138-141 7758586-1 1995 Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF. Phosphatidylcholines 12-31 nerve growth factor Homo sapiens 180-183 7766652-11 1995 Both cPLA2 and cPLA2S505A were purified from infected Sf9 cells and the specific activity for each of the enzymes was measured in a phosphatidylcholine vesicle fluorescence assay using 1-(10-pyrenedecanyl)arachidonyl-sn-glycero-3-phosphocholine as substrate. Phosphatidylcholines 132-151 phospholipase A2 group IVA Homo sapiens 5-10 7551680-4 1995 Phosphatidylcholine and sphingomyelin were found to be the most effective activators of protein kinase A and tyrosine kinase. Phosphatidylcholines 0-19 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 88-104 7762680-8 1995 Phosphatidylcholine was rapidly degraded by macrophages and the degradation occurred both in the presence and absence of SP-A. Phosphatidylcholines 0-19 surfactant protein A1 Homo sapiens 121-125 7538427-4 1995 VCAM-1 induction is regulated by activation of nuclear factor-kappa B, which can be mediated by a TNF-alpha-responsive phosphatidylcholine-specific phospholipase C (PC-PLC). Phosphatidylcholines 119-138 vascular cell adhesion molecule 1 Homo sapiens 0-6 7538427-4 1995 VCAM-1 induction is regulated by activation of nuclear factor-kappa B, which can be mediated by a TNF-alpha-responsive phosphatidylcholine-specific phospholipase C (PC-PLC). Phosphatidylcholines 119-138 tumor necrosis factor Homo sapiens 98-107 7702604-0 1995 A novel phosphatidylcholine hydrolysing action of C-reactive protein. Phosphatidylcholines 8-27 C-reactive protein Rattus norvegicus 50-68 7721742-3 1995 GTP gamma S-stimulated PLD activity was detected in the membranes when exogenous labeled phosphatidylcholine was used in the presence of phosphatidylethanolamine and phosphatidylinositol 4,5-bisphosphate, but not when [3H]myristic acid-labeled endogenous substrate was used. Phosphatidylcholines 89-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 23-26 8846880-3 1995 The results showed that CT Vc5 inhibits PLA2 activity on phosphatidylcholine liposomes. Phosphatidylcholines 57-76 phospholipase A2 group IB Homo sapiens 40-44 7696254-3 1995 Acyl-labeled N-4-nitrobenzo-2-oxa-1,3-diazole (NBD) -phosphatidylcholine (-PC), -phosphatidylethanolamine (-PE), or -phosphatidylserine (-PS) were incorporated into sperm cells, and the transbilayer location was determined by extraction of probe from cell with excess bovine serum albumin (BSA) or by chemical destruction of probe by sodium dithionite. Phosphatidylcholines 53-72 albumin Homo sapiens 275-288 7742350-6 1995 We concluded that the delta 6-desaturase has an associated lipid surrounding of PC and cholesterol at an approx. Phosphatidylcholines 80-82 fatty acid desaturase 2 Rattus norvegicus 22-40 7538076-5 1995 PAF is an acetylated derivative of phosphatidylcholine which is produced by EC and may act in an autocrine manner. Phosphatidylcholines 35-54 PCNA clamp associated factor Homo sapiens 0-3 7703251-2 1995 Overnight treatment with either PC or SM liposomes causes a substantial enhancement of antigen-stimulated degranulation and phospholipase A2 activity, whereas treatment with a PC/chol mixture results in partial inhibition of the antigen-stimulated response. Phosphatidylcholines 32-34 phospholipase A2 group IB Rattus norvegicus 124-140 7703252-4 1995 The reactivity of the apoA-I-pre-beta-HDL particles with LCAT was in the same order as that in human plasma HDL and in phosphatidylcholine/cholesterol unilamellar vesicles activated by apoA-I when compared on the rate of percent cholesterol esterification. Phosphatidylcholines 119-138 apolipoprotein A1 Homo sapiens 22-28 7703252-4 1995 The reactivity of the apoA-I-pre-beta-HDL particles with LCAT was in the same order as that in human plasma HDL and in phosphatidylcholine/cholesterol unilamellar vesicles activated by apoA-I when compared on the rate of percent cholesterol esterification. Phosphatidylcholines 119-138 apolipoprotein A1 Homo sapiens 185-191 7626245-8 1995 The peptide was confined to the bilayer headgroup/water region, similar to that reported from neutron diffraction measurement of tripeptides bound to the phosphatidylcholine bilayer surface (Ref 1). Phosphatidylcholines 154-173 tissue factor pathway inhibitor 2 Homo sapiens 191-196 7896791-7 1995 Addition of one acyl chain from diglyceride to triglyceride, lysophosphatidylcholine to phosphatidylcholine, or cholesterol to cholesteryl ester increased the rate of MTP-mediated transport 10-fold. Phosphatidylcholines 65-84 microsomal triglyceride transfer protein Homo sapiens 167-170 7706325-0 1995 Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step. Phosphatidylcholines 4-23 cut-like homeobox 1 Mus musculus 94-97 7706325-0 1995 Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step. Phosphatidylcholines 4-23 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 154-193 7893681-0 1995 Effect of cholesterol, fatty acyl chain composition, and bilayer curvature on the interaction of cytochrome b5 with liposomes of phosphatidylcholines. Phosphatidylcholines 129-149 cytochrome b5 type A Homo sapiens 97-110 7576493-1 1995 In the present study, we examined the effect of vasopressin (AVP) on phosphatidylcholine-hydrolyzing phospholipase D activity in primary cultured rat aortic smooth muscle cells. Phosphatidylcholines 69-88 arginine vasopressin Rattus norvegicus 48-59 7836750-0 1995 Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. Phosphatidylcholines 50-69 interleukin 3 Homo sapiens 6-10 7532666-8 1995 These findings support the idea that the human MIP-1 alpha receptor is coupled to phospholipid and cAMP metabolism in a manner similar to other 7-transmembrane, G-protein-linked receptors and suggest that a phosphatidylcholine hydrolytic cycle and an associated increase in cAMP are part of the mechanisms of action of MIP-1 alpha. Phosphatidylcholines 207-226 C-C motif chemokine ligand 3 Homo sapiens 47-58 7532666-0 1995 Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression. Phosphatidylcholines 74-93 C-C motif chemokine ligand 3 Homo sapiens 0-39 7532666-4 1995 We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly. Phosphatidylcholines 249-268 C-C motif chemokine ligand 3 Homo sapiens 115-126 7532666-4 1995 We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly. Phosphatidylcholines 249-268 C-C motif chemokine ligand 3 Homo sapiens 168-179 7532666-4 1995 We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly. Phosphatidylcholines 270-272 C-C motif chemokine ligand 3 Homo sapiens 115-126 7532666-4 1995 We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly. Phosphatidylcholines 270-272 C-C motif chemokine ligand 3 Homo sapiens 168-179 7532666-6 1995 Both exogenous PC and dibutyryl cAMP were found to suppress the proliferation of M07e colony-forming cells to a level similar to that of MIP-1 alpha, further implicating cAMP and PC metabolism in MIP-1 alpha-induced M07e suppression. Phosphatidylcholines 15-17 C-C motif chemokine ligand 3 Homo sapiens 196-207 7876145-7 1995 The inhibitor also enhanced EGF-stimulated [3H]diacylglycerol formation in cells preincubated with [3H]arachidonic acid, which labeled predominantly phosphatidylinositol, but inhibited [3H]diacylglycerol production in cells preincubated with [3H]myristic acid, which labeled mainly phosphatidylcholine. Phosphatidylcholines 282-301 epidermal growth factor Mus musculus 28-31 7876145-8 1995 These data support the conclusion that EGF can stimulate diacylglycerol formation from PtdIns(4,5)P2 and that PKC performs the dual role of down-regulating this response as well as mediating phosphatidylcholine hydrolysis. Phosphatidylcholines 191-210 epidermal growth factor Mus musculus 39-42 7876145-8 1995 These data support the conclusion that EGF can stimulate diacylglycerol formation from PtdIns(4,5)P2 and that PKC performs the dual role of down-regulating this response as well as mediating phosphatidylcholine hydrolysis. Phosphatidylcholines 191-210 protein kinase C, alpha Mus musculus 110-113 7836750-14 1995 These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction. Phosphatidylcholines 203-222 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 59-64 7857976-1 1995 The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 66-82 7836750-14 1995 These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction. Phosphatidylcholines 203-222 interleukin 3 Homo sapiens 78-82 7857976-1 1995 The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 84-88 7836750-14 1995 These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction. Phosphatidylcholines 203-222 interleukin 3 receptor subunit alpha Homo sapiens 196-201 7836750-14 1995 These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction. Phosphatidylcholines 203-222 interleukin 3 Homo sapiens 196-200 7751812-13 1995 The use of a fluorescent dialkyl- instead of diacyl-glycerophosphocholine for transfer studies was mandatory, as we found that lipoproteins contained phospholipase A2 activity toward long-chain phosphatidylcholine. Phosphatidylcholines 194-213 phospholipase A2 group IB Homo sapiens 150-166 8529867-1 1995 Monohydrochloride of [2-(decyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C10A) has a biphasic effect on the fluidity of egg yolk phosphatidylcholine (EYPC) model membranes as detected by the methyl ester of stearic acid spin probe, with the paramagnetic doxyl group bound to C-16. Phosphatidylcholines 145-164 endogenous retrovirus group K member 16 Homo sapiens 89-93 7857307-4 1995 As a potent inhibitor of S-adenosylhomocysteine hydrolase, aristeromycin inhibited methylation of phosphatidylethanolamine to form phosphatidylcholine in K562 cells. Phosphatidylcholines 131-150 adenosylhomocysteinase Homo sapiens 25-57 7864076-1 1995 Previous studies from this laboratory have shown that in cultured rat mesangial cells (MC), angiotensin II (ANG II) mediates its effects via activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PC-PLD). Phosphatidylcholines 214-233 angiotensinogen Rattus norvegicus 92-106 7864076-1 1995 Previous studies from this laboratory have shown that in cultured rat mesangial cells (MC), angiotensin II (ANG II) mediates its effects via activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PC-PLD). Phosphatidylcholines 214-233 angiotensinogen Rattus norvegicus 108-114 7751812-4 1995 In low density lipoprotein (LDL) and high density lipoprotein-3 (HDL3) the fluorescent PC analog showed only monomer fluorescence, whereas in Lp[a] and HDL2 monomer and excimer fluorescence were observed, indicating that the fluorescent phosphatidylcholine analog was incorporated into the respective lipoproteins to a different extent. Phosphatidylcholines 87-89 HDL3 Homo sapiens 37-63 7751815-8 1995 The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P < 0.0001). Phosphatidylcholines 116-118 phosphatidylcholine-sterol acyltransferase Macaca fascicularis 30-66 7751812-4 1995 In low density lipoprotein (LDL) and high density lipoprotein-3 (HDL3) the fluorescent PC analog showed only monomer fluorescence, whereas in Lp[a] and HDL2 monomer and excimer fluorescence were observed, indicating that the fluorescent phosphatidylcholine analog was incorporated into the respective lipoproteins to a different extent. Phosphatidylcholines 87-89 HDL3 Homo sapiens 65-69 7751815-8 1995 The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P < 0.0001). Phosphatidylcholines 116-118 phosphatidylcholine-sterol acyltransferase Macaca fascicularis 68-72 7751815-8 1995 The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P < 0.0001). Phosphatidylcholines 169-171 phosphatidylcholine-sterol acyltransferase Macaca fascicularis 30-66 7751815-8 1995 The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P < 0.0001). Phosphatidylcholines 169-171 phosphatidylcholine-sterol acyltransferase Macaca fascicularis 68-72 7751815-9 1995 When the distribution of LCAT-derived rHDL cholesteryl esters was analyzed, LCAT demonstrated little selectivity for certain PC molecular species except in n-3 Poly-derived rHDL where 18:2-containing PC was selectively utilized. Phosphatidylcholines 125-127 phosphatidylcholine-sterol acyltransferase Macaca fascicularis 76-80 7784893-1 1995 Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid. Phosphatidylcholines 190-209 phospholipase A2 group IB Rattus norvegicus 58-74 7784893-1 1995 Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid. Phosphatidylcholines 190-209 phospholipase A2 group IB Rattus norvegicus 76-80 7832781-8 1995 This concentration of PMA significantly increased [14C]PtdCho levels in both control and PKC alpha-over-expressing lines, although the effect in the latter was significantly greater. Phosphatidylcholines 55-61 protein kinase C, alpha Mus musculus 89-98 7836412-1 1995 Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 192-211 cholecystokinin Rattus norvegicus 48-63 7836412-1 1995 Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 192-211 cholecystokinin Rattus norvegicus 65-68 7836412-1 1995 Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 192-211 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 120-159 7832781-11 1995 Although additional PKC subtypes appear to participate in the control of PtdCho synthesis in these cells, PMA-stimulated choline uptake in Swiss 3T3 fibroblasts is almost entirely dependent on the presence of PKC alpha. Phosphatidylcholines 73-79 protein kinase C, alpha Mus musculus 20-23 7816798-6 1995 Finally, whereas the SEC14p-dependent inhibition of CCTase in vitro was markedly reduced under assay conditions that were expected to increase levels of phosphatidylinositol-bound SEC14p, assay conditions expected to increase levels of phosphatidylcholine-bound SEC14p resulted in significant potentiation of CCTase inhibition. Phosphatidylcholines 236-255 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 21-27 7814396-1 1995 CTP:phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells. Phosphatidylcholines 77-96 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 7757108-3 1995 We found that at neutral pH and low ionic strength beta 2-GPI bound to liposome membranes containing cardiolipin with a dissociation constant (Kd) of 10(-8) M. Phosphatidylglycerol, phosphatidylserine, phosphatidic acid or phosphatidylinositol bound to beta 2-GPI, but phosphatidylcholine did not. Phosphatidylcholines 269-288 apolipoprotein H Bos taurus 51-61 7816798-6 1995 Finally, whereas the SEC14p-dependent inhibition of CCTase in vitro was markedly reduced under assay conditions that were expected to increase levels of phosphatidylinositol-bound SEC14p, assay conditions expected to increase levels of phosphatidylcholine-bound SEC14p resulted in significant potentiation of CCTase inhibition. Phosphatidylcholines 236-255 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 52-58 7816798-7 1995 The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled. Phosphatidylcholines 37-56 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 71-77 7816798-7 1995 The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled. Phosphatidylcholines 37-56 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 175-181 7816798-7 1995 The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled. Phosphatidylcholines 37-56 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 237-243 7816798-7 1995 The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled. Phosphatidylcholines 37-56 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 237-243 7893853-2 1995 In cholinergic neurons PLA2 controls the physico-chemical properties of neuronal membranes as well as the breakdown of phosphatidylcholine to produce choline for acetylcholine synthesis. Phosphatidylcholines 119-138 phospholipase A2 group IB Homo sapiens 23-27 7899461-1 1995 The involvement of phospholipase D (PLD) in phosphatidylcholine hydrolysis by epidermal (EGF), insulin-like (IGF-I), and basic fibroblast (bFGF) growth factors was investigated in rat pancreatic acini. Phosphatidylcholines 44-63 epidermal growth factor Rattus norvegicus 89-92 7493735-0 1995 [Phosphatidylcholine induces an increase in the production of interleukin-6 and improves survival of rats with neonatal sepsis caused by Klebsiella pneumoniae]. Phosphatidylcholines 1-20 interleukin 6 Rattus norvegicus 62-75 7559741-6 1995 The purified P-glycoprotein was reconstituted by detergent dialysis into liposomes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine. Phosphatidylcholines 95-114 ATP binding cassette subfamily B member 1 Homo sapiens 13-27 7798907-8 1995 The purified PLA2 displays a preference for phosphatidylcholine as a substrate but hydrolyzes phospholipid substrates with arachidonic acid or linoleic acid esterified at the sn-2 position to the same extent. Phosphatidylcholines 44-63 LOC104974671 Bos taurus 13-17 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. Phosphatidylcholines 127-129 phospholipase A2 group IB Rattus norvegicus 16-32 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. Phosphatidylcholines 127-129 phospholipase A2 group IB Rattus norvegicus 34-38 7869846-2 1995 As the product of the rate-limiting step in the synthesis of phosphatidylcholine from choline, CDP-choline and its hydrolysis products (cytidine and choline) play important roles in generation of phospholipids involved in membrane formation and repair. Phosphatidylcholines 61-80 cut like homeobox 1 Homo sapiens 95-98 7799956-8 1995 Treatment with the phosphatidylcholine-specific phospholipase C inhibitor D609 suppressed LPS-mediated, but not CSF-1-mediated, activation of Raf-1, MEK, and MAPK. Phosphatidylcholines 19-38 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 142-147 7799956-8 1995 Treatment with the phosphatidylcholine-specific phospholipase C inhibitor D609 suppressed LPS-mediated, but not CSF-1-mediated, activation of Raf-1, MEK, and MAPK. Phosphatidylcholines 19-38 mitogen-activated protein kinase kinase 7 Homo sapiens 149-152 7899461-1 1995 The involvement of phospholipase D (PLD) in phosphatidylcholine hydrolysis by epidermal (EGF), insulin-like (IGF-I), and basic fibroblast (bFGF) growth factors was investigated in rat pancreatic acini. Phosphatidylcholines 44-63 insulin-like growth factor 1 Rattus norvegicus 95-114 7989342-6 1994 Instead, CSF-1 enhanced the rate of exogenous arachidonic acid incorporation into phosphatidylcholine and its subsequent transfer to phosphatidylethanolamine suggesting that higher rates of arachidonic acid acylation may contribute to the suppression of prostaglandin production. Phosphatidylcholines 82-101 colony stimulating factor 1 (macrophage) Mus musculus 9-14 7539565-0 1995 [The effect of phosphatidylcholine on repair processes in liver cells in acute CCl4 damage]. Phosphatidylcholines 15-34 C-C motif chemokine ligand 4 Rattus norvegicus 79-83 7539565-1 1995 Effect of phosphatidylcholine, isolated from soy beans and sunflower seeds for laboratory use, on synthesis of RNA, DNA, albumin and content of newly synthesized mRNA in polyribosomes was studied in hepatocytes after chemical hepatectomy produced by single administration of CCl4 into rats; histological and histochemical studies of liver tissue were also carried out. Phosphatidylcholines 10-29 C-C motif chemokine ligand 4 Rattus norvegicus 275-279 7803401-4 1994 MTP was incubated with donor phosphatidylcholine vesicles of varying neutral lipid composition. Phosphatidylcholines 29-48 microsomal triglyceride transfer protein Homo sapiens 0-3 7803401-7 1994 Using phosphatidylcholine emulsions containing 60 mol % triolein as the donor particles resulted in only a slight increase in triolein binding to MTP. Phosphatidylcholines 6-25 microsomal triglyceride transfer protein Homo sapiens 146-149 7527558-3 1994 Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles. Phosphatidylcholines 117-136 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 14-19 7527658-1 1994 The effect of bovine myelin basic protein (MBP) on dimyristoylphosphatidic acid (DMPA) and phosphatidic acid prepared from egg yolk phosphatidylcholine (EPA) has been investigated by transmission and attenuated total reflectance (ATR) Fourier transform infrared spectroscopy. Phosphatidylcholines 132-151 myelin basic protein Bos taurus 21-41 7527658-1 1994 The effect of bovine myelin basic protein (MBP) on dimyristoylphosphatidic acid (DMPA) and phosphatidic acid prepared from egg yolk phosphatidylcholine (EPA) has been investigated by transmission and attenuated total reflectance (ATR) Fourier transform infrared spectroscopy. Phosphatidylcholines 132-151 myelin basic protein Bos taurus 43-46 7527558-3 1994 Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles. Phosphatidylcholines 138-140 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 14-19 7527558-6 1994 The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers. Phosphatidylcholines 88-90 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 19-22 7527558-6 1994 The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers. Phosphatidylcholines 88-90 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 37-42 7527558-6 1994 The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers. Phosphatidylcholines 163-165 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 19-22 7527558-6 1994 The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers. Phosphatidylcholines 163-165 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 37-42 7811715-0 1994 Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activity. Phosphatidylcholines 37-56 arachidonate 5-lipoxygenase Homo sapiens 6-20 7811715-1 1994 A Ca2+ and a phosphatidylcholine (PC) as stimulatory factors to human 5-lipoxygenase (5-LO) were assessed to examine aspects of the regulatory mechanism of 5-LO. Phosphatidylcholines 34-36 arachidonate 5-lipoxygenase Homo sapiens 70-84 7998990-5 1994 Ang II also caused the hydrolysis of phosphatidylinositol and phosphatidylcholine, the formation of phosphatidic acid and the formation of phosphatidylethanol (PEt) in the presence of ethanol, through activation of a PLD and a PLD-induced transphosphatidylation reaction. Phosphatidylcholines 62-81 angiotensinogen Rattus norvegicus 0-6 7998994-0 1994 Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines. Phosphatidylcholines 112-132 dynein axonemal heavy chain 8 Homo sapiens 65-71 7998998-1 1994 Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem. Phosphatidylcholines 143-162 kininogen 1 Homo sapiens 0-10 7998998-1 1994 Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 7988135-21 1994 CONCLUSIONS: a) TNF-alpha alters the amounts of phosphatidylcholine, phosphatidylinositol, and possibly phosphatidylglycerol present in the lavage-accessible space of the isolated perfused rat lung. Phosphatidylcholines 48-67 tumor necrosis factor Rattus norvegicus 16-25 7998998-1 1994 Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 34-53 superoxide dismutase 1 Homo sapiens 3-6 7964753-9 1994 Of these proteins, only MARCKS appears to be correlated with phorbol ester stimulation of phosphatidylcholine turnover in these cells. Phosphatidylcholines 90-109 myristoylated alanine rich protein kinase C substrate Homo sapiens 24-30 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 0-2 superoxide dismutase 1 Homo sapiens 132-135 7731062-0 1994 Selective activation by atrial natriuretic factor of phosphatidylcholine-specific phospholipase activities in purified heart muscle plasma membranes. Phosphatidylcholines 53-72 natriuretic peptide A Rattus norvegicus 24-49 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 34-53 superoxide dismutase 1 Homo sapiens 132-135 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 34-53 superoxide dismutase 1 Homo sapiens 132-135 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 0-2 superoxide dismutase 1 Homo sapiens 3-6 7996483-2 1994 PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique. Phosphatidylcholines 0-2 superoxide dismutase 1 Homo sapiens 132-135 7947996-0 1994 Sodium oleate-facilitated reassembly of apolipoprotein A-I with phosphatidylcholine. Phosphatidylcholines 64-83 apolipoprotein A1 Homo sapiens 40-58 7961983-3 1994 Lecithin:cholesterol acyltransferase (LCAT) cofactor function, measured as cholesterol esterification occurring when t-apo-phosphatidylcholine-cholesterol complexes were incubated with purified enzyme, decreased significantly when pairs of repeats between residues 117 and 248 were deleted and most markedly when residues 117-160 were deleted. Phosphatidylcholines 123-142 lecithin-cholesterol acyltransferase Homo sapiens 0-36 7961983-3 1994 Lecithin:cholesterol acyltransferase (LCAT) cofactor function, measured as cholesterol esterification occurring when t-apo-phosphatidylcholine-cholesterol complexes were incubated with purified enzyme, decreased significantly when pairs of repeats between residues 117 and 248 were deleted and most markedly when residues 117-160 were deleted. Phosphatidylcholines 123-142 lecithin-cholesterol acyltransferase Homo sapiens 38-42 7947996-1 1994 The influence of sodium oleate (oleate) on complexing of apolipoprotein A-I (apo A-I) with egg yolk phosphatidylcholine (EYPC) was evaluated. Phosphatidylcholines 100-119 apolipoprotein A1 Homo sapiens 57-75 7947996-1 1994 The influence of sodium oleate (oleate) on complexing of apolipoprotein A-I (apo A-I) with egg yolk phosphatidylcholine (EYPC) was evaluated. Phosphatidylcholines 100-119 apolipoprotein A1 Homo sapiens 77-84 7947780-1 1994 Surface plasmon resonance (SPR) spectroscopy has been used to follow incorporation and light-induced conformational changes in bovine rhodopsin reconstituted into an egg phosphatidylcholine bilayer deposited on a thin silver film. Phosphatidylcholines 170-189 rhodopsin Bos taurus 134-143 7947733-0 1994 Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase. Phosphatidylcholines 27-46 solute carrier family 38 member 5 Homo sapiens 8-12 7961831-2 1994 Incorporation of 32Pi into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in wild type and ept1 strains was decreased in the presence of exogenous inositol. Phosphatidylcholines 27-46 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 114-118 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 139-141 solute carrier family 38 member 3 Homo sapiens 232-236 7947997-2 1994 Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE. Phosphatidylcholines 100-119 lecithin-cholesterol acyltransferase Homo sapiens 6-42 7947997-2 1994 Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE. Phosphatidylcholines 100-119 lecithin-cholesterol acyltransferase Homo sapiens 44-48 7947997-2 1994 Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE. Phosphatidylcholines 121-123 lecithin-cholesterol acyltransferase Homo sapiens 6-42 7947997-2 1994 Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE. Phosphatidylcholines 121-123 lecithin-cholesterol acyltransferase Homo sapiens 44-48 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 257-259 lecithin-cholesterol acyltransferase Homo sapiens 22-58 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 257-259 lecithin-cholesterol acyltransferase Homo sapiens 60-64 7947733-2 1994 To understand the physicochemical basis for this altered positional specificity, we determined the effect of sn-2 acyl group of PC on the enzyme activity and utilization of 16:0 from the sn-1 position by purified human and rat LCATs. Phosphatidylcholines 128-130 solute carrier family 38 member 5 Homo sapiens 109-113 7947733-0 1994 Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase. Phosphatidylcholines 27-46 lecithin-cholesterol acyltransferase Homo sapiens 92-128 7947733-2 1994 To understand the physicochemical basis for this altered positional specificity, we determined the effect of sn-2 acyl group of PC on the enzyme activity and utilization of 16:0 from the sn-1 position by purified human and rat LCATs. Phosphatidylcholines 128-130 solute carrier family 38 member 3 Homo sapiens 187-191 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 118-137 lecithin-cholesterol acyltransferase Homo sapiens 22-58 7947733-3 1994 Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT. Phosphatidylcholines 22-24 solute carrier family 38 member 5 Homo sapiens 44-48 7947733-3 1994 Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT. Phosphatidylcholines 22-24 lecithin-cholesterol acyltransferase Homo sapiens 82-86 7947733-3 1994 Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT. Phosphatidylcholines 22-24 solute carrier family 38 member 3 Homo sapiens 110-114 7947733-3 1994 Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT. Phosphatidylcholines 22-24 lecithin cholesterol acyltransferase Rattus norvegicus 166-170 7947733-9 1994 These results show that the positional specificity of LCAT is influenced by the structure of PC, especially the chain length of the sn-2 acyl group. Phosphatidylcholines 93-95 lecithin-cholesterol acyltransferase Homo sapiens 54-58 7947733-9 1994 These results show that the positional specificity of LCAT is influenced by the structure of PC, especially the chain length of the sn-2 acyl group. Phosphatidylcholines 93-95 solute carrier family 38 member 5 Homo sapiens 132-136 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 118-137 lecithin-cholesterol acyltransferase Homo sapiens 60-64 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 118-137 solute carrier family 38 member 5 Homo sapiens 101-105 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 139-141 lecithin-cholesterol acyltransferase Homo sapiens 22-58 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 139-141 lecithin-cholesterol acyltransferase Homo sapiens 60-64 7947733-1 1994 Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species. Phosphatidylcholines 139-141 solute carrier family 38 member 5 Homo sapiens 101-105 7961735-5 1994 The CPT1 gene product was responsible for 95% of phosphatidylcholine (PC) synthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 49-68 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 4-8 7957936-0 1994 The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice. Phosphatidylcholines 56-75 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 10-14 7961735-5 1994 The CPT1 gene product was responsible for 95% of phosphatidylcholine (PC) synthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 70-72 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 4-8 7961735-6 1994 The EPT1 gene product accounted for only 5% of PC synthesis in vivo. Phosphatidylcholines 47-49 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 4-8 7957936-2 1994 Mice lacking this protein are unable to secrete phosphatidylcholine (PC) into bile, suggesting that this P-gp is a PC translocator. Phosphatidylcholines 69-71 phosphoglycolate phosphatase Mus musculus 105-109 7961735-7 1994 Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo. Phosphatidylcholines 230-232 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 9-13 7961735-7 1994 Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo. Phosphatidylcholines 230-232 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 186-190 7961735-7 1994 Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo. Phosphatidylcholines 230-232 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 191-195 7961735-12 1994 The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis. Phosphatidylcholines 49-51 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 28-32 7961735-12 1994 The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis. Phosphatidylcholines 127-129 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 28-32 7961735-12 1994 The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis. Phosphatidylcholines 127-129 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 28-32 7961445-5 1994 Such an ethanolamine-dependent reduction in bulk membrane PC content was observed for both choline kinase (cki) and choline phosphotransferase (cpt1) mutants, but it was not observed for mutants defective in cholinephosphate cytidylyltransferase, the enzyme that catalyzes the penultimate reaction of the CDP-choline pathway for PC biosynthesis. Phosphatidylcholines 58-60 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 144-148 7971987-3 1994 When reincorporated into artificial bilayers formed from phosphatidylcholine, it was able to transport a spin-labeled phosphatidylserine analogue from the inner to the outer membrane leaflet provided Mg2+ ATP was present in the incubation mixture. Phosphatidylcholines 57-76 mucin 7, secreted Homo sapiens 200-203 7977654-4 1994 These mice are unable to secrete phospholipids into bile, showing an essential role for the mdr2 P-glycoprotein in the transport of phosphatidylcholine across the canalicular membrane. Phosphatidylcholines 132-151 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 92-96 7977654-4 1994 These mice are unable to secrete phospholipids into bile, showing an essential role for the mdr2 P-glycoprotein in the transport of phosphatidylcholine across the canalicular membrane. Phosphatidylcholines 132-151 ATP binding cassette subfamily B member 1 Homo sapiens 97-111 7895399-4 1994 PLA2 activity was measured in lysates of the various cell fractions by the hydrolysis of radiolabeled lysocholine from phosphatidylcholine, L-Dipalmitoyl using thin layer chromatography. Phosphatidylcholines 119-138 phospholipase A2 group IB Homo sapiens 0-4 7853148-5 1994 Phosphatidylserine is synthesized by the two kinds of base-exchange enzymes, namely serine-exchange enzyme I and II, through the chain reactions in participation of phosphatidylserine decarboxylase; phosphatidylcholine-->phosphatidylserine-->phosphatidylethanolamine--> phosphatidylserine. Phosphatidylcholines 199-218 phosphatidylserine synthase 1 Homo sapiens 84-115 7859925-1 1994 We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 49-68 endothelin 1 Mus musculus 26-38 7859925-1 1994 We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells. Phosphatidylcholines 49-68 endothelin 1 Mus musculus 40-44 7964477-4 1994 CD69 cross-linking resulted also in phospholipase A2 activation, as detected by in vivo arachidonic acid release measurement from intact cells and by direct in vitro measurement of enzymatic activity using radiolabeled phosphatidylcholine vesicles. Phosphatidylcholines 219-238 CD69 molecule Homo sapiens 0-4 7964477-4 1994 CD69 cross-linking resulted also in phospholipase A2 activation, as detected by in vivo arachidonic acid release measurement from intact cells and by direct in vitro measurement of enzymatic activity using radiolabeled phosphatidylcholine vesicles. Phosphatidylcholines 219-238 phospholipase A2 group IB Homo sapiens 36-52 7853148-6 1994 The substrates of serine-exchange enzyme I are phosphatidylcholine, and either choline, serine, or ethanolamine, while those of serine-exchange enzyme II are phosphatidylethanolamine, and serine or ethanolamine but not choline. Phosphatidylcholines 47-66 phosphatidylserine synthase 1 Homo sapiens 18-42 7929289-1 1994 Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa. Phosphatidylcholines 87-89 coagulation factor X Homo sapiens 0-14 7524684-10 1994 Translocation of a PKC isoform could be accounted for by whether the increased DAG originated from PIP2 (accompanied by translocation) or from phosphatidylcholine (no accompanying translocation). Phosphatidylcholines 143-162 protein kinase C, alpha Rattus norvegicus 19-22 7929289-1 1994 Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa. Phosphatidylcholines 87-89 coagulation factor X Homo sapiens 184-222 7819508-1 1994 Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner. Phosphatidylcholines 117-136 coagulation factor II, thrombin Bos taurus 36-47 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. Phosphatidylcholines 36-55 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. Phosphatidylcholines 57-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7819508-1 1994 Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner. Phosphatidylcholines 138-140 coagulation factor II, thrombin Bos taurus 36-47 7931078-16 1994 Furthermore, IL-4R is not coupled to sphingomyelinase (SMase) since IL-4, unlike exogenous SMase, did not generate ceramide but induced the hydrolysis of PC to pchol that was comparable to exogenous PLC. Phosphatidylcholines 154-156 interleukin 4 receptor Homo sapiens 13-18 7931078-16 1994 Furthermore, IL-4R is not coupled to sphingomyelinase (SMase) since IL-4, unlike exogenous SMase, did not generate ceramide but induced the hydrolysis of PC to pchol that was comparable to exogenous PLC. Phosphatidylcholines 154-156 interleukin 4 Homo sapiens 13-17 7931078-6 1994 Experiments were performed using [14C-methyl]choline-labeled U937 cells and monocytes to determine whether IL-4R activated phospholipase C (PLC), PLD, or PLA2 to use membrane phosphatidylcholine (PC) to form DAG. Phosphatidylcholines 175-194 interleukin 4 receptor Homo sapiens 107-112 7931078-8 1994 The finding that the peak reduction of PC was equivalent to peak production of pchol suggested that IL-4R signaling involved the activation of a PC-specific PLC. Phosphatidylcholines 39-41 interleukin 4 receptor Homo sapiens 100-105 7931078-17 1994 In summary, IL-4R signaling in monocytes and U937 cells involves PLC and not PLD, PLA2, or SMase, and it uses PC and not PIP2 to form DAG. Phosphatidylcholines 110-112 interleukin 4 receptor Homo sapiens 12-17 7994181-4 1994 Moreover, assays of soybean AAPT1-encoded enzyme activity in yeast microsomal membranes revealed that the addition of CDP-ethanolamine to the reaction inhibited incorporation of 14C-CDP-choline into phosphatidylcholine in a manner very similar to that observed using unlabeled CDP-choline. Phosphatidylcholines 199-218 aminoalcoholphosphotransferase Glycine max 28-33 7760585-1 1994 CDP-choline participates in brain phospholipid metabolism and acts as an endogenous intermediate in a biosynthetic pathway incorporating free choline into phosphatidylcholine and choline plasmalogens in several tissues, including the central nervous system (CNS). Phosphatidylcholines 155-174 cut like homeobox 1 Homo sapiens 0-3 8001180-5 1994 The lipid mixtures sufficient to yield full photochemical function of rhodopsin include a native-like head group composition, viz, comprising phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS), in combination with polyunsaturated docosahexaenoic acid (DHA; 22:6 omega 3) chains. Phosphatidylcholines 142-161 rhodopsin Homo sapiens 70-79 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 138-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 138-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 159-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 159-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 7945188-4 1994 The PLD activators sphingosine and H2O2 were found to elicit only a slight (1.28-1.4-fold) stimulatory effect on PtdCho hydrolysis in both the MCF-7/WT and MCF-7/MDR cell types, and had only a small effect on PtdEtn hydrolysis in the MCF-7/WT cells as well. Phosphatidylcholines 113-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 8080278-2 1994 When the PC-reconstituted membranes were incubated with ascorbic acid/Fe2+, the ALP activity decreased with increases in the thiobarbituric acid-reactive substances and conjugated diene values in a time-dependent manner. Phosphatidylcholines 9-11 alkaline phosphatase, placental Homo sapiens 80-83 8075084-3 1994 Vaccinia profilin binds to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-monophosphate in micelles and large unilamellar vesicles, but not to phosphatidylserine or phosphatidylcholine. Phosphatidylcholines 183-202 profilin Saccharomyces cerevisiae S288C 9-17 8063752-5 1994 Like SCP2, recombinant SCPx also stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol from small unilamellar vesicles to acceptor membranes in vitro. Phosphatidylcholines 123-142 sterol carrier protein 2 Homo sapiens 23-27 8068732-7 1994 Interestingly, PLA2 able to induce platelet activation efficiently hydrolyse phosphatidylcholine, while those inactive on platelets did not. Phosphatidylcholines 77-96 phospholipase A2 group IIA Homo sapiens 15-19 8068732-9 1994 Moreover, the ability of PLA2 to induce platelet activation is not related to its structural group (I, II, III) but rather to its origin (venom vs. mammalian) and capacity to hydrolyse phosphatidylcholine, the major phospholipid of the outer leaflet of the plasma membrane. Phosphatidylcholines 185-204 phospholipase A2 group IIA Homo sapiens 25-29 7935319-1 1994 Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist. Phosphatidylcholines 140-159 cholinergic receptor muscarinic 3 Homo sapiens 18-40 7935319-1 1994 Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 7935319-1 1994 Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 8049194-1 1994 In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, < 30 seconds). Phosphatidylcholines 222-241 HDL3 Homo sapiens 81-85 8080441-7 1994 All PKC activators stimulated a phospholipase A2-mediated arachidonic acid release, a phospholipase D-mediated phosphatidylcholine hydrolysis, a comparable small proliferative response and an inhibition of phospholipase C-mediated inositol trisphosphate generation. Phosphatidylcholines 111-130 protein kinase C, alpha Rattus norvegicus 4-7 8068618-1 1994 We determined a detailed conformation of the honeybee venom peptide melittin when bound to phosphatidylcholine vesicles using proton NMR. Phosphatidylcholines 91-110 melittin Apis mellifera 68-76 7545943-3 1994 In vitro, MTP catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces. Phosphatidylcholines 78-97 microsomal triglyceride transfer protein Homo sapiens 10-13 8051052-10 1994 A plb1 delta mutant released wild-type levels of the soluble phosphatidylinositol metabolite glycerophosphoinositol into the growth medium but released greatly reduced levels of the corresponding phosphatidylcholine and phosphatidylethanolamine metabolites. Phosphatidylcholines 196-215 lysophospholipase Saccharomyces cerevisiae S288C 2-6 8051052-11 1994 These results indicate that PLB1 is principally responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol. Phosphatidylcholines 110-129 lysophospholipase Saccharomyces cerevisiae S288C 28-32 8049194-1 1994 In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, < 30 seconds). Phosphatidylcholines 222-241 HDL3 Homo sapiens 127-131 8049194-1 1994 In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, < 30 seconds). Phosphatidylcholines 222-241 HDL3 Homo sapiens 127-131 8049194-1 1994 In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, < 30 seconds). Phosphatidylcholines 222-241 HDL3 Homo sapiens 127-131 7857772-0 1994 Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. Phosphatidylcholines 19-38 insulin Homo sapiens 0-7 8053894-3 1994 Vesicles of PtdCho, PtdIns/PtdCho, PtdSer/PtdCho and PtdEtn/PtdCho increased thrombin-thrombomodulin-catalysed protein C activation by 1.2-, 1.9-, 4.3- and 8.4-fold respectively compared with that in the absence of phospholipid. Phosphatidylcholines 12-18 coagulation factor II, thrombin Homo sapiens 77-85 8053894-3 1994 Vesicles of PtdCho, PtdIns/PtdCho, PtdSer/PtdCho and PtdEtn/PtdCho increased thrombin-thrombomodulin-catalysed protein C activation by 1.2-, 1.9-, 4.3- and 8.4-fold respectively compared with that in the absence of phospholipid. Phosphatidylcholines 12-18 thrombomodulin Homo sapiens 86-100 7890144-4 1994 Both membrane-active peptides, cardiotoxin and thionin, inhibited the PLA2 activity on phosphatidylcholine liposomes. Phosphatidylcholines 87-106 phospholipase A2 group IB Homo sapiens 70-74 8034680-3 1994 Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis. Phosphatidylcholines 120-139 tumor necrosis factor Homo sapiens 0-27 7987266-0 1994 Induction of stearoyl-CoA desaturase 2 gene expression correlates with fatty acid changes in phosphatidylcholine. Phosphatidylcholines 93-112 stearoyl-Coenzyme A desaturase 2 Mus musculus 13-38 8034680-3 1994 Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis. Phosphatidylcholines 120-139 tumor necrosis factor Homo sapiens 29-38 8034680-3 1994 Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis. Phosphatidylcholines 120-139 interleukin 1 alpha Homo sapiens 44-57 8048539-2 1994 This increase was accompanied by an increase in CTP:phosphocholine cytidylyltransferase activity, which catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells. Phosphatidylcholines 148-167 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 48-87 8025110-2 1994 Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions. Phosphatidylcholines 52-71 microtubule associated protein 2 Homo sapiens 31-35 8025110-2 1994 Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions. Phosphatidylcholines 52-71 microtubule associated protein 2 Homo sapiens 43-48 8025110-2 1994 Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions. Phosphatidylcholines 52-71 microtubule associated protein 2 Homo sapiens 43-47 8042784-5 1994 RESULTS: Both halothane (50% effective concentration = 2.2 vol%) and propofol (50% effective concentration = 240 microM) markedly stimulated histone H1 phosphorylation by PKC in the presence of a lipid vesicle preparation consisting of phosphatidylcholine, phosphatidylserine, and diacylglycerol. Phosphatidylcholines 236-255 protein kinase C, gamma Rattus norvegicus 171-174 7912658-0 1994 Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Phosphatidylcholines 0-19 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 62-66 8037660-11 1994 We conclude that cholinephosphotransferase catalyses the formation of both phosphatidylcholine and plasmenylcholine in the guinea-pig tissues and the rate of plasmenylcholine biosynthesis is dependent on the availability of 1-alk-1"-enyl-2-acylglycerol. Phosphatidylcholines 75-94 cholinephosphotransferase 1 Cavia porcellus 17-42 7918869-4 1994 That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate. Phosphatidylcholines 162-181 phospholipase A2 group IB Rattus norvegicus 5-9 7918869-4 1994 That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate. Phosphatidylcholines 162-181 phospholipase A2 group IB Rattus norvegicus 111-115 7918869-4 1994 That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate. Phosphatidylcholines 183-185 phospholipase A2 group IB Rattus norvegicus 5-9 8040266-0 1994 Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. Phosphatidylcholines 50-69 tumor necrosis factor Homo sapiens 0-27 8063019-4 1994 PLA2 activity in sonicates from ram spermatozoa was enhanced when 1-stearoyl-2-arachidonoyl-sn-glycerol, the diacylglycerol usually generated by polyphosphoinositide breakdown, was added to a radioactive phosphatidylcholine substrate; the effect was time- and Ca(2+)-dependent. Phosphatidylcholines 204-223 phospholipase A2 group IB Homo sapiens 0-4 7943660-1 1994 UNLABELLED: Phosphatidylethanolamine N-methyltransferase participates in the synthesis of membrane phosphatidylcholine. Phosphatidylcholines 99-118 phosphatidylethanolamine N-methyltransferase Homo sapiens 12-56 8011678-1 1994 The simultaneous incorporation of a saturated fatty acid in the sn-1 position and an unsaturated fatty acid in the sn-2 position in phosphatidylcholine (PC) and ethanolamine (PE) was studied in isolated liver cells. Phosphatidylcholines 132-151 solute carrier family 38 member 5 Homo sapiens 115-119 8011678-1 1994 The simultaneous incorporation of a saturated fatty acid in the sn-1 position and an unsaturated fatty acid in the sn-2 position in phosphatidylcholine (PC) and ethanolamine (PE) was studied in isolated liver cells. Phosphatidylcholines 153-155 solute carrier family 38 member 5 Homo sapiens 115-119 8026481-3 1994 Asymmetrical distributions and translocation kinetics were very different for spin-labeled phosphatidylserine and spin-labeled phosphatidylcholine in fresh platelet plasma membranes. Phosphatidylcholines 127-146 spindlin 1 Homo sapiens 114-118 8026481-5 1994 However, spin-labeled phosphatidylcholine was mainly retained on the external leaflet. Phosphatidylcholines 22-41 spindlin 1 Homo sapiens 9-13 8003498-3 1994 Upon Ca2+ crenation of cells, surface exposure of phosphatidylserine and phosphatidylethanolamine was observed simultaneously with inward diffusion of phosphatidylcholine. Phosphatidylcholines 151-170 carbonic anhydrase 2 Homo sapiens 5-8 8204634-5 1994 The apparent enthalpy of association (delta H(assoc)) of both factor X and prothrombin with phosphatidylserine (PS)/phosphatidylcholine (PC) large unilamellar vesicles (LUVs, 120 nm diameter) was shown to be near 0 kcal/mol. Phosphatidylcholines 116-135 coagulation factor II, thrombin Homo sapiens 75-86 8199206-4 1994 Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation. Phosphatidylcholines 20-39 PCNA clamp associated factor Homo sapiens 76-79 8199206-4 1994 Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation. Phosphatidylcholines 20-39 PCNA clamp associated factor Homo sapiens 215-218 8199206-4 1994 Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation. Phosphatidylcholines 41-43 PCNA clamp associated factor Homo sapiens 76-79 8199206-4 1994 Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation. Phosphatidylcholines 41-43 PCNA clamp associated factor Homo sapiens 215-218 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 8199202-3 1994 The administration of the drug enhanced the formation in vivo of PtdCho from [3H]glycerol, which seemed to be due to the increase in activity of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 65-71 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 145-184 7943660-4 1994 Phosphatidylethanolamine N-methyltransferase activity was measured in sequential percutaneous needle liver biopsies by the conversion of phosphatidylethanolamine to phosphatidylcholine, using radioactive S-adenosylmethionine as a methyl donor. Phosphatidylcholines 165-184 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 7943660-12 1994 Phosphatidylcholine administration ameliorates the ethanol-induced decrease in phosphatidylethanolamine N-methyltransferase activity and corrects phospholipid and phosphatidylcholine depletions, thereby possibly contributing to the protection against alcoholic liver injury. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Homo sapiens 79-123 8200132-12 1994 Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues. Phosphatidylcholines 74-93 endothelin receptor type A Mus musculus 65-68 8200132-12 1994 Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues. Phosphatidylcholines 95-97 endothelin receptor type A Mus musculus 65-68 8090060-0 1994 Effects of soybean lipoxygenase-1 on phosphatidylcholines containing furan fatty acids. Phosphatidylcholines 37-57 seed linoleate 13S-lipoxygenase-1 Glycine max 19-33 8090060-6 1994 F-acids located at the sn-2 position of a synthetic phosphatidylcholine (PC), containing linoleic acid in the sn-1 position, are co-oxidized to a greater extent by incubation with soybean lipoxygenase-1 than are F-acids bound to PC with myristic acid in the sn-1 position when subjected to the enzyme in the presence of a great excess of linoleic acid. Phosphatidylcholines 52-71 seed linoleate 13S-lipoxygenase-1 Glycine max 188-202 8196611-1 1994 v-Src-induced increases in diglyceride are derived from phosphatidylcholine via a type D phospholipase (PLD) and a phosphatidic acid phosphatase. Phosphatidylcholines 56-75 Rous sarcoma oncogene Mus musculus 2-5 8090060-6 1994 F-acids located at the sn-2 position of a synthetic phosphatidylcholine (PC), containing linoleic acid in the sn-1 position, are co-oxidized to a greater extent by incubation with soybean lipoxygenase-1 than are F-acids bound to PC with myristic acid in the sn-1 position when subjected to the enzyme in the presence of a great excess of linoleic acid. Phosphatidylcholines 73-75 seed linoleate 13S-lipoxygenase-1 Glycine max 188-202 8039770-7 1994 In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed. Phosphatidylcholines 83-102 heparan sulfate proteoglycan 2 Homo sapiens 112-115 8196611-2 1994 v-Src-induced PLD activity, as measured by PLD-catalyzed transphosphatidylation of phosphatidylcholine to phosphatidylethanol, is inhibited by GDP beta S, which inhibits G-protein-mediated intracellular signals. Phosphatidylcholines 83-102 Rous sarcoma oncogene Mus musculus 2-5 8196611-4 1994 The effect of GTP gamma S on PLD activity in v-Src-transformed cells was observed only when cells were prelabeled with [3H]myristate, which is incorporated exclusively into phosphatidylcholine, the substrate for the v-Src-induced PLD. Phosphatidylcholines 173-192 Rous sarcoma oncogene Mus musculus 47-50 8196611-4 1994 The effect of GTP gamma S on PLD activity in v-Src-transformed cells was observed only when cells were prelabeled with [3H]myristate, which is incorporated exclusively into phosphatidylcholine, the substrate for the v-Src-induced PLD. Phosphatidylcholines 173-192 Rous sarcoma oncogene Mus musculus 218-221 8039770-7 1994 In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed. Phosphatidylcholines 83-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 120-123 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 52-71 kininogen 1 Homo sapiens 0-2 8182058-1 1994 Sonicated unilamellar phosphatidylcholine vesicles induce hemoglobin oxidation in erythrocytes and resealed membrane fragments (buds) at pH 5.5. Phosphatidylcholines 22-41 HGB Sus scrofa 58-68 7940575-0 1994 Exposure of phosphatidylcholine and phosphatidylinositol in plasma membranes from rat brain synaptosomes treated with phospholipase A2 toxins (beta-bungarotoxin, notexin) and enzymes (Naja nigricollis, Naja naja atra). Phosphatidylcholines 12-31 phospholipase A2 group IB Rattus norvegicus 118-134 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 73-75 kininogen 1 Homo sapiens 0-2 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8011929-11 1994 An appropriate combination (75:25) of phosphatidylcholine from rat liver with phosphatidylethanolamines from cold adapted species showed a drastic fluidization at the C-2 segment, in comparison with their phosphatidylcholines. Phosphatidylcholines 38-57 complement C2 Rattus norvegicus 167-170 8172918-1 1994 Incubation of radiolabeled vasoactive intestinal polypeptide (VIP) with preformed lipid vesicles composed of phosphatidylcholine, phosphatidylglycerol and cholesterol resulted in reversible and saturable association of the peptide with the lipid bilayer. Phosphatidylcholines 109-128 vasoactive intestinal peptide Homo sapiens 27-60 8172918-1 1994 Incubation of radiolabeled vasoactive intestinal polypeptide (VIP) with preformed lipid vesicles composed of phosphatidylcholine, phosphatidylglycerol and cholesterol resulted in reversible and saturable association of the peptide with the lipid bilayer. Phosphatidylcholines 109-128 vasoactive intestinal peptide Homo sapiens 62-65 8071599-7 1994 Phosphatidylcholine increased apoB synthesis and secretion without affecting the synthesis or secretion of apoA-I. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 30-34 7513707-4 1994 An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF. Phosphatidylcholines 187-206 TNF receptor superfamily member 8 Homo sapiens 67-75 7513707-4 1994 An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF. Phosphatidylcholines 187-206 colony stimulating factor 1 Homo sapiens 133-138 8071599-8 1994 Phosphatidylcholine also reversed the effect of A23187 on apoB secretion. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 58-62 8071599-9 1994 When phosphatidylcholine was added to the basolateral medium, apoB secretion was not altered. Phosphatidylcholines 5-24 apolipoprotein B Homo sapiens 62-66 8071599-17 1994 Phosphatidylcholine, independent of triacylglycerol flux and independent of its hydrolysis, increases the secretion of apoB by increasing apoB synthesis. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 119-123 8071599-17 1994 Phosphatidylcholine, independent of triacylglycerol flux and independent of its hydrolysis, increases the secretion of apoB by increasing apoB synthesis. Phosphatidylcholines 0-19 apolipoprotein B Homo sapiens 138-142 8071599-18 1994 Luminal phosphatidylcholine may play a role in apoB secretion in the intestine. Phosphatidylcholines 8-27 apolipoprotein B Homo sapiens 47-51 7512965-13 1994 (iii) Adhesion of alpha 5 beta 1-containing liposomes (phosphatidylcholine:cholesterol liposomes incorporating purified alpha 5 beta 1) to FN-coated plates was abolished by treatment of liposomes with endo-F/PNGase-F. Liposomes incorporating alpha 5 beta 1 pretreated with endo-F/PNGase-F also did not bind to FN. Phosphatidylcholines 55-74 fibronectin 1 Homo sapiens 139-141 8051988-5 1994 CDP-choline (cytidine-5-diphosphate-choline) participates in the phospholipid metabolism pathway incorporating free choline into phosphatidyl-choline and choline plasmalogens in several tissues, including the central nervous system. Phosphatidylcholines 129-149 cut like homeobox 1 Homo sapiens 0-3 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8161559-2 1994 Fluorescence quenching studies show that cholesterol-containing phosphatidylcholines can bind at the lipid-protein interface of the Ca(2+)-ATPase from skeletal muscle sarcoplasmic reticulum, with an affinity half that of dioleoylphosphatidylcholine. Phosphatidylcholines 64-84 dynein axonemal heavy chain 8 Homo sapiens 139-145 8161559-3 1994 The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine. Phosphatidylcholines 90-109 dynein axonemal heavy chain 8 Homo sapiens 4-10 8161559-3 1994 The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine. Phosphatidylcholines 90-109 dynein axonemal heavy chain 8 Homo sapiens 37-43 8161559-3 1994 The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine. Phosphatidylcholines 90-109 dynein axonemal heavy chain 8 Homo sapiens 37-43 8161559-4 1994 The activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing a myristoleoyl fatty acyl chain, (C14:1, CHS)PC, is less than that measured in (C18:1,CHS)PC and is comparable to that measured in dimyristoleoylphosphatidylcholine (di(C14: 1)PC. Phosphatidylcholines 83-102 dynein axonemal heavy chain 8 Homo sapiens 30-36 8144637-10 1994 In addition, the rate of 2AP transfer from A- and H-FABP was enhanced by unsaturation of the phosphatidylcholine acyl chains and was slowed by the presence of cholesterol or sphingomyelin in the acceptor membranes. Phosphatidylcholines 93-112 fatty acid binding protein 3 Homo sapiens 50-56 8166635-3 1994 ACBP was able to extract hexadecanoyl-CoA from phosphatidylcholine membranes immobilized on a nitrocellulose membrane. Phosphatidylcholines 47-66 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 0-4 8053546-9 1994 These results show that a fluorescent assay can be used to rapidly assess the activity of PLD and other phosphatidylcholine-utilizing phospholipases in cell and tissue extracts. Phosphatidylcholines 104-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 90-93 8053546-2 1994 A rapid assay for agonist-activated PLD activity in cell extracts was developed, utilizing a fluorescent derivative of phosphatidylcholine as substrate. Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 8043301-4 1994 In contrast, the rate of incorporation of labeled choline into PC, presumably via CDP-choline, was virtually identical in cells that had been preincubated in the presence or absence of 1 mM choline. Phosphatidylcholines 63-65 cut like homeobox 1 Homo sapiens 82-85 8133286-0 1994 Monogalactosyl diglyceride, a marker for myelination, activates oligodendroglial protein kinase C. Protein kinase C (PKC) is activated by 1,2-sn-diacylglycerol (DAG), the source of which can either be phosphatidylinositol bisphosphate or phosphatidylcholine. Phosphatidylcholines 238-257 protein kinase C alpha Homo sapiens 117-120 8135530-1 1994 The reaction of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and Ebselen with phospholipid and cholesterylester hydroperoxides associated with HDLox and LDLox was investigated using specific HPLC assays for the hydroperoxides of phosphatidylcholine (PCOOH) and cholesteryllinolate (Ch18:2-OOH) and for cholesteryllinolate hydroxides (Ch18:2-OH). Phosphatidylcholines 242-261 glutathione peroxidase 4 Homo sapiens 67-72 8132633-8 1994 Thin layer chromatography of the HDL3 phospholipid fraction from five normolipidemic subjects revealed that it consists of approximately 84% phosphatidylcholine, 12% sphingomyelin, and 4% phosphatidylinositol (PI) by weight. Phosphatidylcholines 141-160 HDL3 Homo sapiens 33-37 8132522-6 1994 The difference increased to 740-fold using TF relipidated in vesicles composed of 80% phosphatidylcholine and 20% phosphatidylserine (TF/PCPS). Phosphatidylcholines 86-105 coagulation factor III, tissue factor Homo sapiens 43-45 8144898-11 1994 CRP binding to complement-treated liposomes required phosphatidylcholine in addition to the MAC indicating that membrane phospholipids rather than the MAC proteins provide the binding sites for CRP. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 0-3 8118639-6 1994 The synthesis of PC by pneumocytes in both the donor (1.13 +/- 0.19 versus 3.44 +/- 0.19 pmol/micrograms protein, p < 0.01) and cancer (0.99 +/- 0.11 versus 2.15 +/- 0.15 pmol/micrograms protein, p < 0.01) groups was decreased by TNF-alpha (100 ng/ml). Phosphatidylcholines 17-19 tumor necrosis factor Homo sapiens 236-245 8203755-1 1994 A method for the determination of the relative amounts of the diacyl, alkylacyl, and alk-1-enylacyl subclasses of choline glycerophospholipids by benzoolysis is described. Phosphatidylcholines 114-142 secretory leukocyte peptidase inhibitor Homo sapiens 85-90 8141780-0 1994 Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway. Phosphatidylcholines 130-149 epidermal growth factor Homo sapiens 0-23 8166295-3 1994 ET-1 stimulated the secretion of PC in a time- and dose-dependent manner. Phosphatidylcholines 33-35 endothelin 1 Rattus norvegicus 0-4 7998342-1 1994 Peroxidation of lipids induced by methemoglobin in liposomes forms of mixtures of phosphatidylcholine and cardiolipin has been studied. Phosphatidylcholines 82-101 hemoglobin subunit gamma 2 Homo sapiens 34-47 8177371-4 1994 With choline phosphoglyceride as a substrate, phospholipase A2 activity was predominantly Ca(2+)-dependent, although a small, but measurable Ca(2+)-independent component was present. Phosphatidylcholines 5-29 phospholipase A2, group IB, pancreas Mus musculus 46-62 8177371-6 1994 These findings indicate that activity of a phospholipase A2, which utilizes choline phosphoglyceride as a substrate, is affected by the aging process. Phosphatidylcholines 76-100 phospholipase A2, group IB, pancreas Mus musculus 43-59 8123678-5 1994 Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids. Phosphatidylcholines 69-88 lipoprotein(a) Homo sapiens 0-4 8123005-3 1994 Since GH stimulates the formation of diacylglycerol from phosphatidylcholine independently of Ca2+ mobilization, the role of Ca2+ was studied in regard to LPL gene expression stimulated by GH. Phosphatidylcholines 57-76 growth hormone Mus musculus 6-8 7508929-3 1994 With unilamellar vesicles (including 20 mol% brain phosphatidylserine), increased phosphatidylcholine unsaturation potentiated basal and phorbol ester stimulated PKC activity. Phosphatidylcholines 82-101 protein kinase C, gamma Rattus norvegicus 162-165 7508929-6 1994 When the PKC activities with vesicles of varying phosphatidylcholine unsaturation, with and without phosphatidylethanolamine, were plotted as a function of the fluorescence intensity of C6-NBD-PC-labeled vesicles, a biphasic profile was obtained, which had an optimum value of intensity, relating to head group spacing, that corresponded to a maximal enzyme activity. Phosphatidylcholines 49-68 protein kinase C, gamma Rattus norvegicus 9-12 7508929-9 1994 Therefore, increasing the level of phosphatidylcholine unsaturation, phosphatidylethanolamine, or cholesterol either potentiates or attenuates PKC activity, dependent on whether the initial condition is above or below its optimum. Phosphatidylcholines 35-54 protein kinase C, gamma Rattus norvegicus 143-146 8119280-2 1994 In 1990, we reported that neutral phosphatidylcholine membranes also stimulated prothrombin activation [Gerads, I., Govers-Riemslag, J.W.P., Tans, G., Zwaal, R. F. A. Phosphatidylcholines 34-53 coagulation factor II, thrombin Homo sapiens 80-91 8119280-5 1994 In the present study, we have performed a detailed analysis of the prothrombin-converting activity of phosphatidylcholine membranes. Phosphatidylcholines 102-121 coagulation factor II, thrombin Homo sapiens 67-78 8119280-6 1994 Stimulation of prothrombin activation by phosphatidylcholine vesicles was particularly observed (a) with phosphatidylcholine molecules that contained unsaturated hydrocarbon side chains, (b) in the presence of factor Va, (c) at low ionic strength and (d) when Ca2+ were present in the reaction medium. Phosphatidylcholines 41-60 coagulation factor II, thrombin Homo sapiens 15-26 8119280-6 1994 Stimulation of prothrombin activation by phosphatidylcholine vesicles was particularly observed (a) with phosphatidylcholine molecules that contained unsaturated hydrocarbon side chains, (b) in the presence of factor Va, (c) at low ionic strength and (d) when Ca2+ were present in the reaction medium. Phosphatidylcholines 105-124 coagulation factor II, thrombin Homo sapiens 15-26 8119280-14 1994 This indicates that similar interactions may account for the assembly of prothrombinase complexes on phosphatidylcholine and an anionic lipid-containing membranes. Phosphatidylcholines 101-120 coagulation factor X Homo sapiens 73-87 8119913-0 1994 Overexpression of rat liver CTP:phosphocholine cytidylyltransferase accelerates phosphatidylcholine synthesis and degradation. Phosphatidylcholines 80-99 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 28-67 8119913-4 1994 The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction. Phosphatidylcholines 88-90 cut-like homeobox 1 Rattus norvegicus 4-7 8119913-4 1994 The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction. Phosphatidylcholines 88-90 cut-like homeobox 1 Rattus norvegicus 73-76 8123678-5 1994 Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids. Phosphatidylcholines 69-88 lipoprotein(a) Homo sapiens 12-16 8123678-5 1994 Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids. Phosphatidylcholines 69-88 lipoprotein(a) Homo sapiens 12-16 8123678-5 1994 Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids. Phosphatidylcholines 69-88 lipoprotein(a) Homo sapiens 12-16 8123681-1 1994 CTP:phosphocholine cytidylyltransferase catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine in alveolar type II cells. Phosphatidylcholines 112-131 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 8307196-2 1994 Purified cytochrome b559 relipidated with either a mixture of phosphatidylcholine and phosphatidic acid or with phosphatidylcholine only exhibits high and low superoxide (O2-) producing ability, respectively, in the absence of cytosolic activators [Koshkin, V. and Pick, E. (1993) FEBS Lett. Phosphatidylcholines 62-81 mitochondrially encoded cytochrome b Homo sapiens 9-21 8106403-6 1994 This substantial loss of activity was reconciled with the apparent retention of the integrity of the Ca(2+)-dependent conformation of this mutant by the finding that this Ca(2+)-dependent conformation of [Leu5-->Gln]r-PC interacted poorly with mixed (60:40, w/w) phosphatidylcholine/phosphatidylserine (PL) vesicles. Phosphatidylcholines 266-285 tripartite motif containing 13 Homo sapiens 205-209 8307196-2 1994 Purified cytochrome b559 relipidated with either a mixture of phosphatidylcholine and phosphatidic acid or with phosphatidylcholine only exhibits high and low superoxide (O2-) producing ability, respectively, in the absence of cytosolic activators [Koshkin, V. and Pick, E. (1993) FEBS Lett. Phosphatidylcholines 112-131 mitochondrially encoded cytochrome b Homo sapiens 9-21 8307196-6 1994 High affinity binding of FAD to cytochrome b559 relipidated with phosphatidylcholine combined with phosphatidic acid is associated with an enhanced NADPH-driven O2- producing capacity. Phosphatidylcholines 65-84 mitochondrially encoded cytochrome b Homo sapiens 32-44 8307196-6 1994 High affinity binding of FAD to cytochrome b559 relipidated with phosphatidylcholine combined with phosphatidic acid is associated with an enhanced NADPH-driven O2- producing capacity. Phosphatidylcholines 65-84 2,4-dienoyl-CoA reductase 1 Homo sapiens 148-153 8306341-6 1994 Prelabeling cells with [3H]glycerol or [3H]-choline demonstrated rapid release of [3H]phosphorylcholine and a decrease in [3H]glycerol-labeled phosphatidylcholine in response to IL-3 stimulation. Phosphatidylcholines 143-162 interleukin 3 Homo sapiens 178-182 8305444-11 1994 NOESY experiments showed that the AC2 molecules forming the micelle structures have hindered motion compared to conventional short-chain phosphatidylcholine micelles. Phosphatidylcholines 137-156 adenylate cyclase 2 Homo sapiens 34-37 8306341-0 1994 Human interleukin-3 stimulates a phosphatidylcholine specific phospholipase C and protein kinase C translocation. Phosphatidylcholines 33-52 interleukin 3 Homo sapiens 6-19 8304830-5 1994 RESULTS: The human rHDL suppressed TNF-alpha production with the products having the highest fraction of phosphatidyl choline producing the greatest suppression of TNF-alpha production. Phosphatidylcholines 105-125 tumor necrosis factor Homo sapiens 35-44 8304830-5 1994 RESULTS: The human rHDL suppressed TNF-alpha production with the products having the highest fraction of phosphatidyl choline producing the greatest suppression of TNF-alpha production. Phosphatidylcholines 105-125 tumor necrosis factor Homo sapiens 164-173 8306341-8 1994 It is thus likely that interleukin-3 is activating a phosphatidylcholine specific phospholipase C rather than a phospholipase D. Finally, genistein and herbimycin, specific tyrosine kinase inhibitors, inhibited both IL-3 induced protein kinase C translocation and the accumulation of diacylglycerol. Phosphatidylcholines 53-72 interleukin 3 Homo sapiens 23-36 8294512-4 1994 We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained. Phosphatidylcholines 183-202 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 16-22 8174753-2 1994 The differential effects of inhibitors of protein kinase (PK) or tyrosine kinase (TK) on phosphatidylcholine (PC) biosynthesis in monocyte-like U937 cells were compared in pulse-chase-studies in which the cells prelabelled with [3H]choline for 30 min were chased in the absence or presence of kinase inhibitors. Phosphatidylcholines 89-108 TXK tyrosine kinase Homo sapiens 82-84 8174753-2 1994 The differential effects of inhibitors of protein kinase (PK) or tyrosine kinase (TK) on phosphatidylcholine (PC) biosynthesis in monocyte-like U937 cells were compared in pulse-chase-studies in which the cells prelabelled with [3H]choline for 30 min were chased in the absence or presence of kinase inhibitors. Phosphatidylcholines 110-112 TXK tyrosine kinase Homo sapiens 82-84 8174753-10 1994 In contrast, TK inhibitor (genistein) markedly stimulated CT and PC biosynthesis, while erbstatin and tyrphostin No. Phosphatidylcholines 65-67 TXK tyrosine kinase Homo sapiens 13-15 8174763-8 1994 The present results suggest that PC is a unique substrate for human intestinal ALP, which may be related to the metabolism of PC or choline as part of phosphatidylcholine. Phosphatidylcholines 151-170 alkaline phosphatase, placental Homo sapiens 79-82 8294512-3 1994 The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 78-97 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 26-32 8294482-8 1994 Repression of transcription of ITR1 also requires ongoing synthesis of phosphatidylcholine, defining an additional link between synthesis of phospholipids and regulation of inositol uptake. Phosphatidylcholines 71-90 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 31-35 8294512-3 1994 The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 78-97 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 161-167 8294512-3 1994 The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 206-225 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 26-32 8294512-3 1994 The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. Phosphatidylcholines 206-225 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 161-167 8025588-5 1994 Interestingly, 90% of the sera from syphilis patients and 6% of the autoimmune patients exhibited a significant binding to platelet-activating factor (PAF), a molecule similar to the structure of phosphatidylcholine. Phosphatidylcholines 196-215 PCNA clamp associated factor Homo sapiens 123-149 8025588-5 1994 Interestingly, 90% of the sera from syphilis patients and 6% of the autoimmune patients exhibited a significant binding to platelet-activating factor (PAF), a molecule similar to the structure of phosphatidylcholine. Phosphatidylcholines 196-215 PCNA clamp associated factor Homo sapiens 151-154 8294444-1 1994 Although the site-directed C73S mutation in the ADP/ATP carrier (AAC) AAC2 gene from Saccharomyces cerevisiae produced a glycerol-positive strain, indicating that the mutant AAC is active, on isolation and reconstitution in egg yolk phosphatidylcholine, the C73S AAC had no transport activity, whereas the wild-type AAC was fully active. Phosphatidylcholines 233-252 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 70-74 8176620-6 1994 Combined antenatal low-dose dexamethasone and TRH significantly reduced mean lung glycogen concentration (P = .001), and increased mean disaturated phosphatidylcholine content (P < .005) to better than that observed with either therapy alone, without changing mean body or lung weight. Phosphatidylcholines 148-167 thyrotropin releasing hormone Homo sapiens 46-49 8294426-1 1994 Binding of cytochrome c (cyt c) to cardiolipin/phosphatidylcholine (CL/PC) and phosphatidylglycerol/PC (PG/PC) liposomes was studied at neutral pH utilizing fluorescence resonance energy transfer from a membrane-incorporated pyrene phospholipid derivative to the heme of cyt c. Phosphatidylcholines 47-66 cytochrome c, somatic Homo sapiens 11-23 8294426-1 1994 Binding of cytochrome c (cyt c) to cardiolipin/phosphatidylcholine (CL/PC) and phosphatidylglycerol/PC (PG/PC) liposomes was studied at neutral pH utilizing fluorescence resonance energy transfer from a membrane-incorporated pyrene phospholipid derivative to the heme of cyt c. Phosphatidylcholines 47-66 cytochrome c, somatic Homo sapiens 25-30 8280752-4 1994 This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT). Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Homo sapiens 116-160 7506931-1 1994 Human myelin basic protein (MBP) is shown to disrupt multilamellar phosphatidylcholine bilayers into small lipoprotein particles in a manner similar to the cytolytic peptide melittin (Dufourc, E. J., Smith, I. C. P., & Dufourcq, J. Phosphatidylcholines 67-86 myelin basic protein Homo sapiens 6-26 7506931-1 1994 Human myelin basic protein (MBP) is shown to disrupt multilamellar phosphatidylcholine bilayers into small lipoprotein particles in a manner similar to the cytolytic peptide melittin (Dufourc, E. J., Smith, I. C. P., & Dufourcq, J. Phosphatidylcholines 67-86 myelin basic protein Homo sapiens 28-31 8280752-4 1994 This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT). Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Homo sapiens 162-166 8280763-1 1994 Isolated Golgi apparatus, highly purified from rat liver, were found to contain an acyl transfer activity capable of restoring the acyl chains of the lysophospholipid products of the action of phospholipase A2 on phosphatidylcholine. Phosphatidylcholines 213-232 phospholipase A2 group IB Rattus norvegicus 193-209 8138720-4 1994 Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis. Phosphatidylcholines 12-31 lipase E, hormone sensitive type Rattus norvegicus 106-109 8264633-1 1994 In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus. Phosphatidylcholines 114-133 perlecan (heparan sulfate proteoglycan 2) Mus musculus 177-180 7864659-9 1994 The results demonstrated that lysoPC, a phospholipase A2-generated hydrolysis product of phosphatidylcholine, induced T-lymphocyte chemotaxis in vitro. Phosphatidylcholines 89-108 phospholipase A2 group IB Homo sapiens 40-56 7864659-10 1994 Because phosphatidylcholine is the major phospholipid in the epidermis, the activation of phospholipase A2 may result in the release of lysoPC in concentrations capable of inducing migration of T lymphocytes into the epidermis. Phosphatidylcholines 8-27 phospholipase A2 group IB Homo sapiens 90-106 8187205-5 1994 Fluorescent analogs of phosphatidylcholine and sphingomyelin were inserted into the surface layer of LDL and Lp(a). Phosphatidylcholines 23-42 lipoprotein(a) Homo sapiens 109-114 8187205-8 1994 Higher affinity for Lp(a) as compared with LDL was also observed with a fluorescent diether analog of phosphatidylcholine in native serum. Phosphatidylcholines 102-121 lipoprotein(a) Homo sapiens 20-25 8263514-8 1994 Bradykinin stimulated diacylglycerol production in neuroblastoma cells by increasing the hydrolysis of both phosphoinositides and phosphatidylcholine. Phosphatidylcholines 130-149 kininogen 1 Homo sapiens 0-10 8139391-0 1994 Biphasic modulation of choline uptake and phosphatidylcholine biosynthesis by vasopressin in rat cardiac myocytes. Phosphatidylcholines 42-61 arginine vasopressin Rattus norvegicus 78-89 8139391-4 1994 The biosynthesis of phosphatidylcholine was also affected by vasopressin in a biphasic manner. Phosphatidylcholines 20-39 arginine vasopressin Rattus norvegicus 61-72 8139391-5 1994 At low concentrations of vasopressin, a general increase in cytosine triphosphate:phosphocholine cytidylyltransferase activity was observed that caused an enhanced conversion of phosphocholine to phosphatidylcholine via the cytidine diphosphocholine pathway. Phosphatidylcholines 196-215 arginine vasopressin Rattus norvegicus 25-36 8264633-1 1994 In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus. Phosphatidylcholines 135-137 perlecan (heparan sulfate proteoglycan 2) Mus musculus 177-180 8264633-1 1994 In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus. Phosphatidylcholines 135-137 perlecan (heparan sulfate proteoglycan 2) Mus musculus 279-282 8264633-7 1994 Taken together, our results show that chronic stimulation of PC hydrolysis by an unregulated PC-PLC enzyme is oncogenic to NIH 3T3 cells. Phosphatidylcholines 61-63 perlecan (heparan sulfate proteoglycan 2) Mus musculus 96-99 8138720-4 1994 Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis. Phosphatidylcholines 12-31 lipase E, hormone sensitive type Rattus norvegicus 149-152 8138720-4 1994 Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis. Phosphatidylcholines 210-229 lipase E, hormone sensitive type Rattus norvegicus 106-109 8288878-4 1993 The sensitivity of RIA for PAF was notably higher than that for sn-2-short-chain PAF-like phosphatidylcholines. Phosphatidylcholines 90-110 PCNA clamp associated factor Homo sapiens 81-84 8280053-1 1993 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a phosphatidylcholine-requiring tetrameric enzyme with two thiol groups (SH-1 and SH-2) per protomer. Phosphatidylcholines 47-66 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 37-40 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 8128456-9 1993 Secreted phospholipase A2 hydrolyzed phosphatidylethanolamine at 5-12 times the rate of phosphatidylcholine when the substrates were present in pure form. Phosphatidylcholines 88-107 phospholipase A2 group IB Homo sapiens 9-25 8246981-0 1993 Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Phosphatidylcholines 14-33 zinc fingers and homeoboxes 2 Homo sapiens 63-66 8263781-6 1993 Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 8263781-6 1993 Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 8263781-9 1993 It was concluded that ACh-induced esophageal contraction depends preferentially on M2 receptors, a PTX-sensitive G13 protein, phosphatidylcholine-specific PLD and production of diacylglycerol (DAG) and is independent of IP3 formation and the release of intracellular Ca++. Phosphatidylcholines 126-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 155-158 8307580-1 1993 CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. Phosphatidylcholines 74-93 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 8246981-1 1993 We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals. Phosphatidylcholines 60-79 zinc fingers and homeoboxes 2 Homo sapiens 107-110 8246981-1 1993 We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals. Phosphatidylcholines 81-83 zinc fingers and homeoboxes 2 Homo sapiens 107-110 8251487-1 1993 A fluorescent assay based on concentration-dependent self-quenching of the fluorescent phospholipid N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine was used to measure the rate of phospholipid exchange between taurocholate/phosphatidylcholine mixed micelles. Phosphatidylcholines 237-256 OXA1L mitochondrial inner membrane protein Homo sapiens 117-122 8292693-1 1993 We measured serum phospholipase A2 (PLA2) activity in 39 schizophrenics, 26 psychiatric controls, and 26 normal controls using a radioenzymatic assay with phosphatidylcholine as precursor. Phosphatidylcholines 155-174 phospholipase A2 group IB Homo sapiens 18-34 8106172-6 1993 We conclude that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholipid flippase. Phosphatidylcholines 83-102 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 21-25 8251517-1 1993 Purified adrenocortical microsomal P-450C21 was incorporated into vesicle membranes composed of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine at a molar ratio of 5:3:1. Phosphatidylcholines 96-115 steroid 21-hydroxylase Bos taurus 35-43 8240288-0 1993 Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. Phosphatidylcholines 18-37 choline phosphotransferase 1 Homo sapiens 83-108 8240288-3 1993 PC biosynthesis was inhibited to one-quarter at the step catalysed by cholinephosphotransferase (CPT). Phosphatidylcholines 0-2 choline phosphotransferase 1 Homo sapiens 70-95 8240288-3 1993 PC biosynthesis was inhibited to one-quarter at the step catalysed by cholinephosphotransferase (CPT). Phosphatidylcholines 0-2 choline phosphotransferase 1 Homo sapiens 97-100 8292693-1 1993 We measured serum phospholipase A2 (PLA2) activity in 39 schizophrenics, 26 psychiatric controls, and 26 normal controls using a radioenzymatic assay with phosphatidylcholine as precursor. Phosphatidylcholines 155-174 phospholipase A2 group IB Homo sapiens 36-40 8298012-1 1993 The nonideal mixing of phosphatidylserine (PS) and phosphatidylcholine (PC) binary lipid mixtures was studied by computer simulation based on a model wherein the excess energy of mixing is divided between an electrostatic term and one adjustable term delta Em that includes all other nonideal interactions. Phosphatidylcholines 51-70 surfactant protein C Homo sapiens 72-74 8130082-0 1993 Epidermal growth factor increases 32P incorporation into phosphatidylcholine and protein kinase C activity in colon carcinoma cell line (HT29). Phosphatidylcholines 57-76 epidermal growth factor Homo sapiens 0-23 8268464-0 1993 Phospholipase D-mediated hydrolysis of phosphatidylcholine: role in cell signalling. Phosphatidylcholines 39-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 8293516-3 1993 The efficiency of the SOD-entrapment into the positively charged multilamellar vesicles (MLVs), comprising egg yolk phosphatidylcholine and synthetic glucosamine diesters, was enhanced by the addition of cholesterol to the membranes. Phosphatidylcholines 116-135 superoxide dismutase 1 Homo sapiens 22-25 7508272-10 1993 The human serum phospholipase A2 strongly preferred E. coli membranes as substrate to the mixed micelles containing phosphatidylcholine/phosphatidylethanolamine. Phosphatidylcholines 116-135 phospholipase A2 group IB Homo sapiens 16-32 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidylcholines 89-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidylcholines 110-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8264152-2 1993 In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid. Phosphatidylcholines 163-182 angiogenin Homo sapiens 15-18 8264152-2 1993 In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid. Phosphatidylcholines 163-182 phospholipase A2 group IB Homo sapiens 96-112 8264152-2 1993 In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid. Phosphatidylcholines 163-182 phospholipase A2 group IB Homo sapiens 114-118 8397115-1 1993 The role of Ca2+ and protein kinase C (PKC) in the regulation of phosphatidylcholine-hydrolyzing phospholipase D (PLD) was investigated in angiotensin II-stimulated mesangial cells. Phosphatidylcholines 65-84 protein kinase C, alpha Rattus norvegicus 39-42 8399288-11 1993 The present study extends this work to investigate the effects of PC and PS on platelet responses to a natural agonist, thrombin. Phosphatidylcholines 66-68 coagulation factor II, thrombin Homo sapiens 120-128 8411362-0 1993 Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. Phosphatidylcholines 0-19 nuclear factor kappa B subunit 1 Homo sapiens 41-51 8411362-1 1993 We have tested whether breakdown of phosphatidylcholine (PC) initiated by exogenous addition of a PC-specific phospholipase C (PC-PLC) from Bacillus cereus or by endogenous overexpression of PC-PLC induces functional activation of NF-kappa B and increases human immunodeficiency virus (HIV) enhancer activity. Phosphatidylcholines 36-55 nuclear factor kappa B subunit 1 Homo sapiens 231-241 8411362-1 1993 We have tested whether breakdown of phosphatidylcholine (PC) initiated by exogenous addition of a PC-specific phospholipase C (PC-PLC) from Bacillus cereus or by endogenous overexpression of PC-PLC induces functional activation of NF-kappa B and increases human immunodeficiency virus (HIV) enhancer activity. Phosphatidylcholines 57-59 nuclear factor kappa B subunit 1 Homo sapiens 231-241 8411362-2 1993 PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin. Phosphatidylcholines 0-2 nuclear factor kappa B subunit 1 Homo sapiens 64-67 8411362-2 1993 PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin. Phosphatidylcholines 0-2 RELA proto-oncogene, NF-kB subunit Homo sapiens 68-71 8411362-2 1993 PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin. Phosphatidylcholines 0-2 nuclear factor kappa B subunit 1 Homo sapiens 72-82 8399233-1 1993 The photobleaching process of iodopsin (a chicken red-sensitive cone visual pigment) purified in a detergent system containing CHAPS and phosphatidylcholine was investigated by means of nanosecond laser photolysis at room temperature. Phosphatidylcholines 137-156 opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan) Gallus gallus 30-38 8397115-1 1993 The role of Ca2+ and protein kinase C (PKC) in the regulation of phosphatidylcholine-hydrolyzing phospholipase D (PLD) was investigated in angiotensin II-stimulated mesangial cells. Phosphatidylcholines 65-84 angiotensinogen Rattus norvegicus 139-153 8227406-6 1993 With phosphatidylserine:phosphatidylcholine vesicles at a concentration of 1 microM:2 microM, beta 2 GPI began to inhibit the reaction at a concentration of 15 nM, and at 4 microM (the normal plasma concentration) the activation of protein C was reduced to 40%. Phosphatidylcholines 24-43 apolipoprotein H Homo sapiens 94-104 8286511-6 1993 RESULTS: All three cytokines, particularly TNF-alpha, inhibited the incorporation of D-glucose uniformly labelled with 14C (D-(U-14C) glucose) into phosphatidylcholine. Phosphatidylcholines 148-167 tumor necrosis factor Homo sapiens 43-52 8286511-8 1993 When palmitate uniformly labelled with 14C was used as the radiolabelled precursor, TNF-alpha stimulated the synthesis of both triacylglycerol and phosphatidylcholine, neither of which was affected by IL-1 or IL-6. Phosphatidylcholines 147-166 tumor necrosis factor Homo sapiens 84-93 8286512-6 1993 RESULTS: TNF-alpha decreased the incorporation of both D-(U-14C) glucose and (U-14C) palmitate into phospholipid fractions, particularly phosphatidylcholine, in both healthy lung tissue and that from patients with lung cancer. Phosphatidylcholines 137-156 tumor necrosis factor Homo sapiens 9-18 8242260-14 1993 The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis. Phosphatidylcholines 252-271 protein kinase C, alpha Rattus norvegicus 22-25 8239304-2 1993 Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. Phosphatidylcholines 50-69 cut-like homeobox 1 Rattus norvegicus 102-105 8399325-5 1993 (4) The pool sizes of the intermediate metabolic products of the CDP-choline-pathway for the synthesis of phosphatidylcholine were also higher in the cells isolated from exposed animals. Phosphatidylcholines 106-125 cut-like homeobox 1 Rattus norvegicus 65-68 8239319-0 1993 Comparative effects of aging process on phosphatidylcholine biosynthesis pathway: a key role for CTP-phosphocholine cytidylyltransferase? Phosphatidylcholines 40-59 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 97-136 8239304-2 1993 Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. Phosphatidylcholines 71-73 cut-like homeobox 1 Rattus norvegicus 102-105 8373761-0 1993 Polymerizable phosphatidylcholines: importance of phospholipid motions for optimum phospholipase A2 and C activity. Phosphatidylcholines 14-34 phospholipase A2 group IB Homo sapiens 83-99 8376375-7 1993 Kinetic studies suggested that: 1) LCAT binds better to substrate vesicles which contain SPH; 2) SPH competes with PC in binding to the active site of the enzyme; and 3) SPH is a more powerful competitive inhibitor than a diether analog of PC. Phosphatidylcholines 115-117 lecithin-cholesterol acyltransferase Homo sapiens 35-39 8376375-8 1993 The ability of various lipoproteins to act as substrates for purified LCAT varied inversely with the SPH/PC ratio. Phosphatidylcholines 105-107 lecithin-cholesterol acyltransferase Homo sapiens 70-74 8396134-3 1993 All of these reactions required activation by human apolipoprotein A-I, suggesting that this activation leads to the deacylation of phosphatidylcholine. Phosphatidylcholines 132-151 apolipoprotein A1 Homo sapiens 52-70 8379928-6 1993 As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages. Phosphatidylcholines 64-83 Rous sarcoma oncogene Mus musculus 110-113 8379928-6 1993 As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages. Phosphatidylcholines 64-83 Rous sarcoma oncogene Mus musculus 183-186 8379928-6 1993 As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages. Phosphatidylcholines 39-41 Rous sarcoma oncogene Mus musculus 110-113 8379928-8 1993 Taken together, these data suggest that v-Src activates a PKC-independent PLD activity that is specific for a subpopulation of PC and distinct from the PLD activity induced by PKC activity induced by phorbol esters. Phosphatidylcholines 127-129 Rous sarcoma oncogene Mus musculus 42-45 8396134-5 1993 Lysophosphatidylcholine that was endogenously generated by deacylation of phosphatidylcholine in the first step of the LCAT reaction was also a good acyl acceptor, showing that the reaction is always partly "idling." Phosphatidylcholines 4-23 lecithin-cholesterol acyltransferase Homo sapiens 119-123 8379928-9 1993 The diacylglycerol produced from PC by the action of the v-Src-induced PLD may therefore be responsible for the activation of PKC by v-Src. Phosphatidylcholines 33-35 Rous sarcoma oncogene Mus musculus 59-62 8237421-10 1993 Furthermore, VIP treatment, and the concomitant cAMP-accumulation, potentiates the acetylcholine induced phosphatidylcholine hydrolysis, demonstrating a new type of interaction between the classical transmitter acetylcholine and the co-stored neuropeptide VIP. Phosphatidylcholines 105-124 vasoactive intestinal peptide Rattus norvegicus 256-259 8379928-9 1993 The diacylglycerol produced from PC by the action of the v-Src-induced PLD may therefore be responsible for the activation of PKC by v-Src. Phosphatidylcholines 33-35 Rous sarcoma oncogene Mus musculus 135-138 8370463-2 1993 The phospholipid topology of the outer membrane of intact rat liver mitochondria and derived outer membrane vesicles was investigated by determining the accessible pool of the various phospholipid classes towards phospholipase A2, a phosphatidylcholine-specific transfer protein and by chemical labeling using trinitrobenzene sulfonic acid. Phosphatidylcholines 233-252 phospholipase A2 group IB Rattus norvegicus 213-229 8237421-10 1993 Furthermore, VIP treatment, and the concomitant cAMP-accumulation, potentiates the acetylcholine induced phosphatidylcholine hydrolysis, demonstrating a new type of interaction between the classical transmitter acetylcholine and the co-stored neuropeptide VIP. Phosphatidylcholines 105-124 vasoactive intestinal peptide Rattus norvegicus 13-16 8368329-0 1993 Pulmonary surfactant protein A-mediated uptake of phosphatidylcholine by alveolar type II cells. Phosphatidylcholines 50-69 surfactant protein A1 Homo sapiens 0-30 8241408-10 1993 A previously proposed universal relation for the perpendicular component of the rotational diffusion tensor, R perpendicular, for CSL in PC/cholesterol mixtures (i.e., R perpendicular = R0 perpendicular exp(-AS2chol/RT)) is confirmed. Phosphatidylcholines 137-139 chorionic somatomammotropin hormone like 1 Homo sapiens 130-133 8403234-10 1993 Although the PL composition of the cells remained essentially unaffected, our study shows that chronic treatment of U937 cells with n - 3 PUFA (20:5) depressed PC and PE synthesis, and 18:3 and 20:4 also caused inhibition of PE synthesis. Phosphatidylcholines 160-162 pumilio RNA binding family member 3 Homo sapiens 138-142 8344945-2 1993 Phosphatidylethanolamine N-methyltransferase catalyzes the synthesis of phosphatidylcholine from phosphatidylethanolamine and is most active in liver. Phosphatidylcholines 72-91 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 7692845-3 1993 Phosphatidylcholine, lysophosphatidylcholine, and phosphatidylethanolamine dose-dependently enhanced the enzyme activity up to 3 fold in the presence of Ca2+, calmodulin, NADPH, FAD, and (6R)-5,6,7,8-tetrahydrobiopterin. Phosphatidylcholines 0-19 calmodulin Bos taurus 159-169 8231655-1 1993 The modulation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis by sulfur-substituted fatty acid analogues has been investigated in rats. Phosphatidylcholines 18-37 procollagen C-endopeptidase enhancer Rattus norvegicus 39-41 8347671-0 1993 Spin-label studies on phosphatidylcholine-polar carotenoid membranes: effects of alkyl-chain length and unsaturation. Phosphatidylcholines 22-41 spindlin 1 Homo sapiens 0-4 8347671-1 1993 Spin-labeling methods were used to study the structure and dynamic properties of phosphatidylcholine (PC)-dihydroxycarotenoid membranes as a function of phospholipid alkyl chain length, alkyl chain saturation, temperature and mol fraction of carotenoids. Phosphatidylcholines 81-100 spindlin 1 Homo sapiens 0-4 8347671-1 1993 Spin-labeling methods were used to study the structure and dynamic properties of phosphatidylcholine (PC)-dihydroxycarotenoid membranes as a function of phospholipid alkyl chain length, alkyl chain saturation, temperature and mol fraction of carotenoids. Phosphatidylcholines 102-104 spindlin 1 Homo sapiens 0-4 8347671-4 1993 (2) The abrupt changes of spin-label motion observed at the main-phase transition of the saturated PC membranes are broadened and shifted to lower temperatures. Phosphatidylcholines 99-101 spindlin 1 Homo sapiens 26-30 8347671-6 1993 (3) In fluid-phase PC membranes possessing short alkyl chains (12-14 carbons), the activation energy of the rotational diffusion of 16-doxylstearic acid spin label (16-SASL) is significantly lower at a carotenoid concentration of 10 mol%. Phosphatidylcholines 19-21 spindlin 1 Homo sapiens 153-157 8368329-1 1993 Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated. Phosphatidylcholines 57-76 surfactant protein A1 Homo sapiens 0-30 8368329-1 1993 Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated. Phosphatidylcholines 57-76 surfactant protein A1 Homo sapiens 32-36 8368329-1 1993 Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated. Phosphatidylcholines 78-80 surfactant protein A1 Homo sapiens 0-30 8368329-1 1993 Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated. Phosphatidylcholines 78-80 surfactant protein A1 Homo sapiens 32-36 8368329-6 1993 Phosphatidylcholine that had been incorporated into lamellar bodies remained largely intact when SP-A was present. Phosphatidylcholines 0-19 surfactant protein A1 Homo sapiens 97-101 7920899-4 1993 Our previous data suggested that phosphatidylcholine which was sonicated with cholesteryl oleate as a substrate may play a crucial role in the regulation of CEase in rat adrenal. Phosphatidylcholines 33-52 carboxyl ester lipase Homo sapiens 157-162 7920899-6 1993 Acid CEase in normal tissue was increased in a dose-dependent manner by phosphatidylcholine, but not in the adenoma or hyperplasia tissues. Phosphatidylcholines 72-91 carboxyl ester lipase Homo sapiens 5-10 8375418-5 1993 The association of apolipoprotein A-I with phosphatidylcholine liposomes resulted in a more than two-fold increase in cholesterol efflux compared to free apolipoprotein A-I, while association of apolipoproteins A-II and C-I with phosphatidylcholine liposomes resulted in a very limited increase in cholesterol efflux above that achieved by the free apolipoproteins. Phosphatidylcholines 43-62 apolipoprotein A1 Homo sapiens 19-37 8344304-1 1993 In the present study the effect of changing the fatty acyl moiety of phosphatidylcholine from dilauroyl to distearoyl on the kinetic parameters of O-dealkylation of alkoxyresorufins and ethoxycoumarin dependent on reconstituted cytochromes P-450 IA1 and IIB1 has been investigated. Phosphatidylcholines 69-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 240-245 8344304-1 1993 In the present study the effect of changing the fatty acyl moiety of phosphatidylcholine from dilauroyl to distearoyl on the kinetic parameters of O-dealkylation of alkoxyresorufins and ethoxycoumarin dependent on reconstituted cytochromes P-450 IA1 and IIB1 has been investigated. Phosphatidylcholines 69-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 254-258 8393878-3 1993 Thus, other signal transduction pathways that hydrolyze phosphatidylcholine (PtdCho) or phosphatidylethanolamine (PtdEth) and form DG and phosphatidic acids (PA) through either PLC or phospholipase D (PLD) may also mediate PAF-stimulated cellular responses. Phosphatidylcholines 56-75 PCNA clamp associated factor Rattus norvegicus 223-226 7900958-4 1993 Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined. Phosphatidylcholines 88-107 heparan sulfate proteoglycan 2 Homo sapiens 117-120 8375418-5 1993 The association of apolipoprotein A-I with phosphatidylcholine liposomes resulted in a more than two-fold increase in cholesterol efflux compared to free apolipoprotein A-I, while association of apolipoproteins A-II and C-I with phosphatidylcholine liposomes resulted in a very limited increase in cholesterol efflux above that achieved by the free apolipoproteins. Phosphatidylcholines 43-62 apolipoprotein A1 Homo sapiens 154-172 7686941-8 1993 These results indicate that the phosphatidylcholine-specific PLD pathway is the main pathway for the production of 1,2-DG in SCF-stimulated rat peritoneal mast cells. Phosphatidylcholines 32-51 KIT ligand Rattus norvegicus 125-128 8504093-9 1993 This enhancement of HL activity occurred at about the same cholesterol concentration as the restoration of triacylglycerol hydrolysis observed for the triacylglycerol/phosphatidylcholine/cholesterol films. Phosphatidylcholines 167-186 lipase C, hepatic type Rattus norvegicus 20-22 8504157-8 1993 The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 349-368 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 8392931-4 1993 In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA. Phosphatidylcholines 44-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8392931-4 1993 In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA. Phosphatidylcholines 65-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8392931-5 1993 We found in bradykinin-stimulated human fibroblasts that PLD mediates transphosphatidylation from PC (donor) to the endogenous "alcohol" DG (acceptor), yielding bis(1,2-diacylglycero)-3-sn-phosphate (bisphosphatidic acid; bisPA). Phosphatidylcholines 98-100 kininogen 1 Homo sapiens 12-22 8392931-5 1993 We found in bradykinin-stimulated human fibroblasts that PLD mediates transphosphatidylation from PC (donor) to the endogenous "alcohol" DG (acceptor), yielding bis(1,2-diacylglycero)-3-sn-phosphate (bisphosphatidic acid; bisPA). Phosphatidylcholines 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 7686368-1 1993 Monoclonal antibodies (mAbs) have been used to study structure-function relationships of (R)-3-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30), a lipid-requiring mitochondrial membrane enzyme with an absolute and specific requirement for phosphatidylcholine (PC) for enzymic activity. Phosphatidylcholines 240-259 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 126-129 7686368-6 1993 Further, for BDH in bilayers containing PC, the C-terminus is protected from carboxy-peptidase cleavage, whereas in bilayers devoid of PC the C-terminus is cleaved, and subsequent activation by PC is precluded. Phosphatidylcholines 40-42 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 13-16 8392813-0 1993 Regulation of phosphatidylcholine synthesis in fetal type II cells by CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 14-33 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 70-109 8392813-3 1993 The developmental profile of the enzymes of the CDP-choline pathway suggests that CTP:choline-phosphate cytidylyltransferase catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells. Phosphatidylcholines 169-188 cut-like homeobox 1 Rattus norvegicus 48-51 7686368-7 1993 We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme. Phosphatidylcholines 152-154 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 40-43 7686368-7 1993 We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme. Phosphatidylcholines 152-154 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 199-202 8392813-7 1993 We speculate that either a subcellular translocation of CTP:phosphocholine cytidylyltransferase from cytosol to microsomes or an increase in cytidylyltransferase gene expression are responsible for the developmental increase of de novo phosphatidylcholine synthesis by fetal type II cells. Phosphatidylcholines 236-255 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 56-95 7686368-7 1993 We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme. Phosphatidylcholines 152-154 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 199-202 8514863-4 1993 The major cytosolic phospholipase A2 isoform preferentially hydrolyzes plasmalogen substrate, possesses a pH optimum of 7.0, and is chromatographically resolvable from a minor cytosolic calcium-independent phospholipase A2 isoform that hydrolyzes plasmenylcholine and phosphatidylcholine substrates at similar rates and possesses a pH optimum of 8.5. Phosphatidylcholines 268-287 phospholipase A2 group IVA Homo sapiens 10-36 7686368-7 1993 We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme. Phosphatidylcholines 248-250 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 40-43 7686368-7 1993 We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme. Phosphatidylcholines 248-250 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 40-43 8324883-4 1993 CDP-choline also did not antagonize the effect of hypoxia on phosphatidylcholine synthesis; rather it accentuated the hypoxia-induced reductions in cellular phosphocholine and phosphatidylcholine biosynthesis. Phosphatidylcholines 176-195 cut-like homeobox 1 Rattus norvegicus 0-3 8324883-5 1993 These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis. Phosphatidylcholines 159-178 cut-like homeobox 1 Rattus norvegicus 60-63 8324883-5 1993 These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis. Phosphatidylcholines 343-362 cut-like homeobox 1 Rattus norvegicus 60-63 8503884-0 1993 Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells. Phosphatidylcholines 0-19 angiotensinogen Homo sapiens 81-95 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 8503884-10 1993 Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor. Phosphatidylcholines 87-93 angiotensinogen Homo sapiens 9-23 8503884-10 1993 Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor. Phosphatidylcholines 87-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 8514863-4 1993 The major cytosolic phospholipase A2 isoform preferentially hydrolyzes plasmalogen substrate, possesses a pH optimum of 7.0, and is chromatographically resolvable from a minor cytosolic calcium-independent phospholipase A2 isoform that hydrolyzes plasmenylcholine and phosphatidylcholine substrates at similar rates and possesses a pH optimum of 8.5. Phosphatidylcholines 268-287 phospholipase A2 group IB Homo sapiens 20-36 8389049-1 1993 In human non-small cell lung cancer cells (PC-14) exposed to DHA-VC for 24 hr, a dose-dependent increase in phosphatidylcholine-specific phospholipase C (PC-PLC) activity was seen. Phosphatidylcholines 108-127 heparan sulfate proteoglycan 2 Homo sapiens 157-160 8099446-1 1993 2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC 3.1.1.4), significantly potentiate the differentiation of HL-60 cells to macrophages that is induced by either a membrane-permeant diacylglycerol or a phorbol ester. Phosphatidylcholines 6-25 phospholipase A2 group IB Homo sapiens 173-189 8388718-7 1993 For comparison we also studied the effects of sphingosine on the phospholipase A2 catalyzed hydrolysis of the pyrene-labeled acidic alkylacyl phospholipid analog 1-octacosanyl-2-[6-(pyren-1-yl)]hexanoyl-sn-glycero-3- phosphatidylmethanol (C28-O-PHPM) and the corresponding phosphatidylcholine (C28-O-PHPC). Phosphatidylcholines 273-292 phospholipase A2 group IB Homo sapiens 65-81 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. Phosphatidylcholines 66-85 cytochrome c, somatic Homo sapiens 165-177 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. Phosphatidylcholines 66-85 cytochrome c, somatic Homo sapiens 179-184 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. Phosphatidylcholines 222-241 cytochrome c, somatic Homo sapiens 165-177 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. Phosphatidylcholines 222-241 cytochrome c, somatic Homo sapiens 179-184 8388334-1 1993 Circular dichroism (CD) and acrylamide quenching studies of Na+,K(+)-ATPase from human placenta showed that its incorporation into phosphatidylcholine vesicles increased the enzymic activity by 55%. Phosphatidylcholines 131-150 dynein axonemal heavy chain 8 Homo sapiens 69-75 8504138-1 1993 The activity of soluble phospholipase A2 to hydrolyze phosphatidylcholine vesicles increases abruptly after a lag time of several minutes. Phosphatidylcholines 54-73 phospholipase A2 group IB Homo sapiens 24-40 8499444-6 1993 Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC. Phosphatidylcholines 262-281 annexin A5 Homo sapiens 143-152 8499444-6 1993 Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC. Phosphatidylcholines 283-285 annexin A5 Homo sapiens 143-152 8499444-6 1993 Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC. Phosphatidylcholines 322-324 annexin A5 Homo sapiens 143-152 8485141-5 1993 The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles. Phosphatidylcholines 337-339 annexin A5 Homo sapiens 161-170 8485141-5 1993 The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles. Phosphatidylcholines 337-339 annexin A5 Homo sapiens 304-313 8485141-5 1993 The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles. Phosphatidylcholines 441-443 annexin A5 Homo sapiens 161-170 8485141-5 1993 The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles. Phosphatidylcholines 441-443 annexin A5 Homo sapiens 304-313 8364491-1 1993 The influence of phosphatidylcholine liposomes on the tryptic digestion of insulin was studied to obtain basic information on the interaction between liposomes and peptides or proteins. Phosphatidylcholines 17-36 insulin Homo sapiens 75-82 8387776-2 1993 PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol. Phosphatidylcholines 74-93 phospholipase C delta 1 Homo sapiens 0-9 8387776-2 1993 PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol. Phosphatidylcholines 95-97 phospholipase C delta 1 Homo sapiens 0-9 8387776-2 1993 PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol. Phosphatidylcholines 134-136 phospholipase C delta 1 Homo sapiens 0-9 8387776-7 1993 These showed that 50% binding of PLC delta occurred at a level of 0.9 nmol/ml PIP2 with 80 nmol/ml PC; at 2.2 nmol/ml PIP2 with 170 nmol/ml PS; at 4.2 nmol/ml PIP2 with 320 nmol/ml PI; and at 0.26 nmol/ml PIP2 with 20 nmol/ml total liver phospholipids. Phosphatidylcholines 99-101 phospholipase C delta 1 Homo sapiens 33-42 8386549-2 1993 The integrated intensities of the saturation transfer EPR spectra from spin-labelled phosphatidylcholine are linearly dependent on the protein/lipid ratio, and correspond to a fixed stoichiometry of approximately 11 lipids per monomer associated with the protein in the gel phase. Phosphatidylcholines 85-104 spindlin 1 Homo sapiens 71-75 8481388-10 1993 In addition to the PLA2 and lyso PLA activities, we report that cPLA2 displays a relatively low, CoA-independent transacylase activity which produces phosphatidylcholine from lysophosphatidylcholine substrate. Phosphatidylcholines 150-169 phospholipase A2 group IVA Homo sapiens 64-69 8324886-7 1993 The infusion of the same dose of phosphatidylcholine without apoA-I was significantly less efficacious. Phosphatidylcholines 33-52 apolipoprotein A-I Oryctolagus cuniculus 61-67 8316043-0 1993 Phosphatidylcholine as substrate for human pancreatic phospholipase A2. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 54-70 8316043-2 1993 The long-chain phosphatidylcholine/sodium cholate aqueous system as substrate for human pancreatic phospholipase A2 (PLA2) was investigated. Phosphatidylcholines 15-34 phospholipase A2 group IB Homo sapiens 99-115 8316043-2 1993 The long-chain phosphatidylcholine/sodium cholate aqueous system as substrate for human pancreatic phospholipase A2 (PLA2) was investigated. Phosphatidylcholines 15-34 phospholipase A2 group IB Homo sapiens 117-121 8316043-10 1993 Phosphatidylcholine was preferred as substrate for human PLA2 when present in large mixed disc-like bile salt micelles. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 57-61 8386549-3 1993 The normalized saturation transfer intensities of spin-labelled phosphatidic acid, on the other hand, display a non-linear dependence on the protein/lipid ratio that can be described well by a selectivity for interaction with the protein in the gel phase with an average association constant relative to phosphatidylcholine of approx. Phosphatidylcholines 304-323 spindlin 1 Homo sapiens 50-54 8389981-2 1993 The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT). Phosphatidylcholines 43-62 cholinephosphotransferase 1 Cavia porcellus 150-175 8387269-4 1993 However, when phosphatidylcholine levels were decreased by incubation with phospholipase A2 (PLA2), there was no significant redistribution of cytidylyltransferase activity. Phosphatidylcholines 14-33 phospholipase A2 group IB Rattus norvegicus 75-91 8387269-4 1993 However, when phosphatidylcholine levels were decreased by incubation with phospholipase A2 (PLA2), there was no significant redistribution of cytidylyltransferase activity. Phosphatidylcholines 14-33 phospholipase A2 group IB Rattus norvegicus 93-97 8387269-5 1993 With PLA2 the concentration of phosphatidylethanolamine, as well as of phosphatidylcholine, was significantly decreased. Phosphatidylcholines 71-90 phospholipase A2 group IB Rattus norvegicus 5-9 8384876-5 1993 This reduction in rotational mobility is also found with purified squid rhodopsin reconstituted in egg phosphatidylcholine and in urea-washed outer segment membranes which have been treated with endoprotease-V8 to remove the C-terminal extension of squid rhodopsin. Phosphatidylcholines 103-122 rhodopsin Bos taurus 72-81 8389981-2 1993 The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT). Phosphatidylcholines 43-62 cholinephosphotransferase 1 Cavia porcellus 177-180 8386623-6 1993 Mixtures of phosphatidylcholine/phosphatidylserine or phospholipids/phosphatidylserine, in ratios of 1-4, increased the insulin-induced tyrosine kinase activation in a dose-dependent manner. Phosphatidylcholines 12-31 insulin Homo sapiens 120-127 8466950-0 1993 Lysosomal phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase: specificity for the sn-1 fatty acid of the donor and co-purification with phospholipase A1. Phosphatidylcholines 10-29 lipase H Homo sapiens 152-168 7951508-4 1993 Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine. Phosphatidylcholines 122-141 carboxyl ester lipase Rattus norvegicus 23-28 7951508-4 1993 Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine. Phosphatidylcholines 215-234 carboxyl ester lipase Rattus norvegicus 23-28 8466950-8 1993 These findings suggest that phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase is catalyzed by lysosomal phospholipase A1. Phosphatidylcholines 28-47 lipase H Homo sapiens 121-137 7951508-5 1993 We have already reported that phosphatidylcholine is an important factor for the regulation of adrenal CEase. Phosphatidylcholines 30-49 carboxyl ester lipase Rattus norvegicus 103-108 7951508-6 1993 Therefore, the present studies show that apoproteins as well as phosphatidylcholine may be important factors for the regulation of adrenal CEase. Phosphatidylcholines 64-83 carboxyl ester lipase Rattus norvegicus 139-144 7951508-4 1993 Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine. Phosphatidylcholines 215-234 carboxyl ester lipase Rattus norvegicus 23-28 8514423-5 1993 In SP, PAF-AH-like activity was Ca(++)-independent, acid and heat labile, stable to freezing, not inhibited by phosphatidylcholine, but was inhibited by 10 mM disopropylfluorophosphate (DFP) and 13 mM phenylmethylsulfonylfluoride (PMSF). Phosphatidylcholines 111-130 phospholipase A2 group VII Homo sapiens 7-13 8462457-10 1993 In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis. Phosphatidylcholines 89-108 coagulation factor II Rattus norvegicus 13-21 8462457-10 1993 In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis. Phosphatidylcholines 193-212 coagulation factor II Rattus norvegicus 13-21 8462457-10 1993 In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis. Phosphatidylcholines 193-212 angiotensinogen Rattus norvegicus 156-170 8384040-8 1993 Reconstitution of the isolated skeletal muscle SR Ca2+ ATPase in phosphatidylcholine membranes in the presence of PLN using the freezing and thawing technique yielded a preparation with lower Ca(2+)-dependent ATPase activity. Phosphatidylcholines 65-84 carbonic anhydrase 2 Homo sapiens 50-53 8514651-1 1993 Hamycin incorporated into liposomes containing phosphatidylcholine (SPC) and phosphatidic acid (PA) had reduced toxicity and an enhanced antifungal activity in experimental aspergillosis in balb/c mice. Phosphatidylcholines 47-66 sparse coat Mus musculus 68-71 8457575-5 1993 The maximum fraction of spin-labeled phospholipids translocated to the inner membrane layer was 84% for phosphatidylserine, 65% for phosphatidylethanolamine, 20-40% for phosphatidylcholine, and below 20% for sphingomyelin. Phosphatidylcholines 169-188 spindlin 1 Homo sapiens 24-28 8383672-4 1993 The stimulation of phosphatidylcholine synthesis was correlated with a decrease in phosphocholine and an increase in CDP-choline, indicating that cytidylyltransferase is regulatory under these conditions. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 117-120 8444905-6 1993 Activation of endogenous phospholipase A2 by mellitin in vivo or hydrolysis of phosphatidylcholine by purified phospholipase A2 in vitro inhibited PDGF receptor autophosphorylation similar to that of purified fatty acids. Phosphatidylcholines 79-98 phospholipase A2 group IB Homo sapiens 111-127 8464355-0 1993 Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment. Phosphatidylcholines 68-87 linoleate 9S-lipoxygenase-4 Glycine max 167-179 8441394-0 1993 Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1. Phosphatidylcholines 0-19 colony stimulating factor 1 (macrophage) Mus musculus 105-132 8441394-1 1993 Stimulation of diglyceride production via phospholipase C (PLC) hydrolysis of phosphatidylcholine was an early event in the mitogenic action of colony-stimulating factor 1 (CSF-1) in the murine macrophage cell line BAC1.2F5 and was followed by a second phase of diglyceride production that persisted throughout the G1 phase of the cell cycle. Phosphatidylcholines 78-97 colony stimulating factor 1 (macrophage) Mus musculus 144-171 8441394-1 1993 Stimulation of diglyceride production via phospholipase C (PLC) hydrolysis of phosphatidylcholine was an early event in the mitogenic action of colony-stimulating factor 1 (CSF-1) in the murine macrophage cell line BAC1.2F5 and was followed by a second phase of diglyceride production that persisted throughout the G1 phase of the cell cycle. Phosphatidylcholines 78-97 colony stimulating factor 1 (macrophage) Mus musculus 173-178 8455032-6 1993 The cell-specific translocation of MARCKS appears to correlate with previously demonstrated differential effects of phorbol esters on stimulation of phosphatidylcholine turnover in these two cell lines. Phosphatidylcholines 149-168 myristoylated alanine rich protein kinase C substrate Mus musculus 35-41 8461337-10 1993 These and previous data suggest that the stimulatory effect of ATP on phosphatidylcholine secretion in type II cells is mediated by three signal-transduction mechanisms: activation of cAMP-dependent protein kinase; activation of protein kinase C; and a calmodulin-dependent mechanism. Phosphatidylcholines 70-89 calmodulin 1 Rattus norvegicus 253-263 8448194-6 1993 Similar studies were performed with S-100a interacting with cardiolipin, phosphatidylserine or egg phosphatidylcholine, both in absence and in presence of 2 mM Ca2+. Phosphatidylcholines 99-118 S100 calcium binding protein A1 Homo sapiens 36-42 8436962-5 1993 GCP phospholipase A2 (PLA2) activity was demonstrated using [3H]-or [14C]AA-phosphatidylcholine (PC) or -PI as the substrate in vitro and GCPs or a cytosolic GCP extract as the source of enzyme. Phosphatidylcholines 76-95 phospholipase A2 group IB Rattus norvegicus 4-20 8436962-5 1993 GCP phospholipase A2 (PLA2) activity was demonstrated using [3H]-or [14C]AA-phosphatidylcholine (PC) or -PI as the substrate in vitro and GCPs or a cytosolic GCP extract as the source of enzyme. Phosphatidylcholines 76-95 phospholipase A2 group IB Rattus norvegicus 22-26 8431204-6 1993 RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls. Phosphatidylcholines 88-107 interleukin 1 beta Homo sapiens 56-65 8431438-0 1993 Effects of phosphatidylcholine fatty acyl chain length on calcium binding and other functions of the (Ca(2+)-Mg2+)-ATPase. Phosphatidylcholines 11-30 dynein axonemal heavy chain 8 Homo sapiens 115-121 8431438-1 1993 The ATPase activity of the (Ca(2+)-Mg2+)-ATPase purified from skeletal muscle sarcoplasmic reticulum and reconstituted into phosphatidylcholine bilayers of defined composition depends on the fatty acyl chain length of the surrounding phospholipid. Phosphatidylcholines 124-143 dynein axonemal heavy chain 8 Homo sapiens 4-10 8431438-1 1993 The ATPase activity of the (Ca(2+)-Mg2+)-ATPase purified from skeletal muscle sarcoplasmic reticulum and reconstituted into phosphatidylcholine bilayers of defined composition depends on the fatty acyl chain length of the surrounding phospholipid. Phosphatidylcholines 124-143 dynein axonemal heavy chain 8 Homo sapiens 41-47 8431455-3 1993 Net intervesicular transfer of the lipo-gastrins to phosphatidyl-choline model bilayers occurs at high rates whereby the chain length of the gastrin lipid moiety was found to affect the transfer rate more decisively than the nature of the acceptor vesicle. Phosphatidylcholines 52-72 gastrin Homo sapiens 40-47 8431455-5 1993 Embedment of the lipo-gastrins in phosphatidylcholine bilayers at high lipid/gastrin ratios as mimicry of the cell membrane bound state does not result in onset of ordered structure, but leads to full exposure of the gastrin in essentially randomly coiled form at the water/lipid interface. Phosphatidylcholines 34-53 gastrin Homo sapiens 22-29 8431455-6 1993 This may result from the artificial N-terminal anchorage of the gastrin molecules to the bilayers, but also from the relatively tight packing of the phosphatidylcholine vesicles. Phosphatidylcholines 149-168 gastrin Homo sapiens 64-71 8428938-6 1993 265, 8610-8617) and demonstrated that all apoA-I variants except apoA-I(Lys107-->0) form discoidal HDL particles with phosphatidylcholine analogues indistinguishable from normal apoA-I (Jonas, A., von Eckardstein, A., Kezdy, K. E., Steinmetz, A., and Assmann, G. (1991) J. Phosphatidylcholines 121-140 apolipoprotein A-I Mus musculus 42-48 8383432-3 1993 Signal transduction involved in this process includes FMLP receptor stimulation of phosphoinositide hydrolysis with formation of inositol 1,4,5-trisphosphate and diacylglycerol and phosphatidylcholine hydrolysis with formation of phosphatidic acid. Phosphatidylcholines 181-200 formyl peptide receptor 1 Homo sapiens 54-58 8383432-9 1993 generation is associated with marked inhibition of phospholipase D (PLD) activity, with limited hydrolysis of phosphatidylcholine and formation of phosphatidic acid. Phosphatidylcholines 110-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-71 8382903-1 1993 CTP:phosphocholine cytidylyltransferase (CT) is a key regulatory enzyme in phosphatidylcholine biosynthesis. Phosphatidylcholines 75-94 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 8431438-2 1993 The stoichiometry of Ca2+ binding to the ATPase is also sensitive to fatty acyl chain length, changing from the normal two Ca2+ ions bound per ATPase molecule to one Ca2+ ion bound for the ATPase reconstituted with phosphatidylcholines of chain lengths C12, C14, or C24. Phosphatidylcholines 215-235 dynein axonemal heavy chain 8 Homo sapiens 41-47 8431438-3 1993 For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase. Phosphatidylcholines 45-65 dynein axonemal heavy chain 8 Homo sapiens 8-14 8431438-3 1993 For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase. Phosphatidylcholines 45-65 dynein axonemal heavy chain 8 Homo sapiens 415-421 8431438-3 1993 For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase. Phosphatidylcholines 45-64 dynein axonemal heavy chain 8 Homo sapiens 8-14 8431438-3 1993 For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase. Phosphatidylcholines 45-64 dynein axonemal heavy chain 8 Homo sapiens 415-421 8431438-5 1993 Effects of short-chain phosphatidylcholines on Ca2+ binding stoichiometry and on ATPase activity can be reversed by addition of androstenol, oleic acid, methyl oleate, or oleyl alcohol but these molecules have no effect on the ATPase reconstituted with dinervonylphosphatidylcholine (C24:1). Phosphatidylcholines 23-43 dynein axonemal heavy chain 8 Homo sapiens 81-87 8431438-5 1993 Effects of short-chain phosphatidylcholines on Ca2+ binding stoichiometry and on ATPase activity can be reversed by addition of androstenol, oleic acid, methyl oleate, or oleyl alcohol but these molecules have no effect on the ATPase reconstituted with dinervonylphosphatidylcholine (C24:1). Phosphatidylcholines 23-43 dynein axonemal heavy chain 8 Homo sapiens 227-233 8431438-6 1993 For the ATPase reconstituted with phosphatidylcholines with chain lengths between C16 and C22, release of the two bound Ca2+ ions is sequential, with release of the second Ca2+ being inhibited by high concentrations of Ca2+ in the bathing medium. Phosphatidylcholines 34-54 dynein axonemal heavy chain 8 Homo sapiens 8-14 8382052-9 1993 These results demonstrate the kinetic mechanism of in vitro catalysis and suggest a regulatory role for CDP-choline concentration in the diacylglycerol species selectivity of cholinephosphotransferase resulting in the de novo biosynthesis of different molecular species of phosphatidylcholine. Phosphatidylcholines 273-292 cut-like homeobox 1 Mus musculus 104-107 8431204-6 1993 RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls. Phosphatidylcholines 109-111 interleukin 1 beta Homo sapiens 56-65 8431204-10 1993 Addition of quinacrine was also demonstrated to abolish the IL-1-induced hydrolysis of PC and PE but not PI, indicating that PC and PE are the preferred substrates for PLA2 enzymatic activity in human synovial cells. Phosphatidylcholines 87-89 phospholipase A2 group IB Homo sapiens 168-172 8431204-10 1993 Addition of quinacrine was also demonstrated to abolish the IL-1-induced hydrolysis of PC and PE but not PI, indicating that PC and PE are the preferred substrates for PLA2 enzymatic activity in human synovial cells. Phosphatidylcholines 125-127 phospholipase A2 group IB Homo sapiens 168-172 8431204-11 1993 CONCLUSION: Our findings strongly suggest that AA and PGE2 production by IL-1-triggered synoviocytes are largely dependent upon PLA2-mediated hydrolysis of PC and PE and to a lesser extent upon the earlier degradation of PI. Phosphatidylcholines 156-158 phospholipase A2 group IB Homo sapiens 128-132 8423794-3 1993 In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Phosphatidylcholines 121-140 insulin S homeolog Xenopus laevis 279-286 8431960-9 1993 As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid. Phosphatidylcholines 37-56 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 62-66 8431960-9 1993 As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid. Phosphatidylcholines 37-56 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 106-110 8431960-9 1993 As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid. Phosphatidylcholines 37-56 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 140-144 8381848-9 1993 We suggest that the impairment of phospholipase D-mediated metabolism of phosphatidylcholine in response to fMLP stimulation of polycythemia vera granulocytes may be of significance for the reduced superoxide anion formation induced by fMLP in those cells. Phosphatidylcholines 73-92 formyl peptide receptor 1 Homo sapiens 108-112 8381848-9 1993 We suggest that the impairment of phospholipase D-mediated metabolism of phosphatidylcholine in response to fMLP stimulation of polycythemia vera granulocytes may be of significance for the reduced superoxide anion formation induced by fMLP in those cells. Phosphatidylcholines 73-92 formyl peptide receptor 1 Homo sapiens 236-240 8423794-3 1993 In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Phosphatidylcholines 121-140 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 81-84 8423794-3 1993 In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Phosphatidylcholines 121-140 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 291-294 8423794-3 1993 In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Phosphatidylcholines 121-140 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 S homeolog Xenopus laevis 167-177 8381273-2 1993 U-PA and ATF stimulated the formation of diacylglycerol (DAG) independently of inositol lipid and phosphatidylcholine turnover, but concomitantly with de novo synthesis from glucose, thus resembling the DAG neosynthesis activated by insulin. Phosphatidylcholines 98-117 plasminogen activator, urokinase Homo sapiens 0-4 8423794-3 1993 In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Phosphatidylcholines 121-140 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 S homeolog Xenopus laevis 253-263 8386398-4 1993 Addition of phospholipid vesicles or treatment with phospholipase C inhibited annexin V binding to platelets, suggesting that phospholipid is the binding site for annexin V and that phosphatidylcholine forms at least part of this site. Phosphatidylcholines 182-201 annexin A5 Homo sapiens 78-87 8424671-1 1993 This contrasts with phosphatidylcholine/phosphatidylserine mixtures which affect the activity of PKC in a manner independent of the fatty acid composition of the phosphatidylcholine. Phosphatidylcholines 20-39 proline rich transmembrane protein 2 Homo sapiens 97-100 8422369-1 1993 Phospholipase A2-catalyzed hydrolysis of phosphatidylcholine large unilamellar vesicles is characterized by a period of slow hydrolysis followed by a rapid increase in the rate of hydrolysis. Phosphatidylcholines 41-60 phospholipase A2 group IB Homo sapiens 0-16 8417975-1 1993 An effect of annexin IV and VI on the fluidity of phosphatidylserine/phosphatidylcholine (PS/PC) membranes was studied by spin labeling technique with the use of 5-doxylstearic acid. Phosphatidylcholines 69-88 surfactant protein C Homo sapiens 90-95 8274032-3 1993 The isolated fractions of phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidyl-ethanolamine (PE) were treated with phospholipase A2 to release fatty acids in the sn-2 position. Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 131-147 8420989-11 1993 When liposomes included a moderate quantity of GM3 (0.22-0.44 micrograms (0.2-0.4 nmol)/55 micrograms of phosphatidylcholine, 33 micrograms of cholesterol, 5 micrograms of alpha 5 beta 1 in liposome), adhesion was enhanced significantly. Phosphatidylcholines 105-124 granulocyte macrophage antigen 3 Mus musculus 47-50 8424671-1 1993 This contrasts with phosphatidylcholine/phosphatidylserine mixtures which affect the activity of PKC in a manner independent of the fatty acid composition of the phosphatidylcholine. Phosphatidylcholines 162-181 proline rich transmembrane protein 2 Homo sapiens 97-100 8318606-3 1993 A deoxycholate extract of a platelet membrane fraction, with a minimum of 15 proteins including GPIb, GPIIb-IIIa and GPIV/III, was incorporated into sphingomyelin: phosphatidylcholine: monosialylganglioside or egg phosphatide small unilamellar vesicles by reverse-phase/sonication and French press extrusion. Phosphatidylcholines 164-183 CD36 molecule Rattus norvegicus 117-121 27280993-0 1993 Substrate Specificity of Rat Plasma Lecithin-cholesterol Acyltransferase towards a Molecular Species of Phosphatidylcholine. Phosphatidylcholines 104-123 lecithin cholesterol acyltransferase Rattus norvegicus 36-72 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-31 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-36 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 407-410 8388315-1 1993 The phosphatidylcholine precursor, cytidine-diphosphocholine (CDP-choline), was injected intraperitoneally (IP) at the dose of 10 or 20 mg/kg/day for 20 days to 24-month-old male rats of the Sprague-Dawley strain that showed cognitive and motor deficits. Phosphatidylcholines 4-23 cut-like homeobox 1 Rattus norvegicus 62-65 27280993-1 1993 The substrate specificity and the affinity of rat purified lecithin-cholesterol acyltransferase towards the molecular species of phosphatidylcholine (PC) were studied in comparison with the human enzyme. Phosphatidylcholines 129-148 lecithin cholesterol acyltransferase Rattus norvegicus 59-95 27280993-1 1993 The substrate specificity and the affinity of rat purified lecithin-cholesterol acyltransferase towards the molecular species of phosphatidylcholine (PC) were studied in comparison with the human enzyme. Phosphatidylcholines 150-152 lecithin cholesterol acyltransferase Rattus norvegicus 59-95 8336521-2 1993 Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine. Phosphatidylcholines 98-117 C-reactive protein Homo sapiens 29-32 8432440-8 1993 Phosphatidyl choline species composed of various acyl fatty acids in the sn-1 and sn-2 positions were used as the sole phospholipid in otherwise identical model bile solutions. Phosphatidylcholines 0-20 solute carrier family 38 member 3 Homo sapiens 73-77 8432440-8 1993 Phosphatidyl choline species composed of various acyl fatty acids in the sn-1 and sn-2 positions were used as the sole phospholipid in otherwise identical model bile solutions. Phosphatidylcholines 0-20 solute carrier family 38 member 5 Homo sapiens 82-86 8336521-3 1993 In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered. Phosphatidylcholines 128-147 C-reactive protein Homo sapiens 221-224 8418887-4 1993 A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol. Phosphatidylcholines 130-149 cut-like homeobox 1 Rattus norvegicus 64-67 8418887-4 1993 A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol. Phosphatidylcholines 277-296 cut-like homeobox 1 Rattus norvegicus 64-67 8418887-6 1993 These results suggest that CDP choline may be a key regulator of the diacylglycerol branchpoint, since diacylglycerol is primarily incorporated into phosphatidylcholine or triacylglycerol depending on whether CDP choline is or is not available. Phosphatidylcholines 149-168 cut-like homeobox 1 Rattus norvegicus 27-30 8445336-0 1993 Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 64-83 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 134-178 8412488-2 1993 A high entrapment of calcitonin (CT) was obtained when the vesicles were prepared by sonication and were composed of egg phosphatidylcholine, cholesterol and stearylamine. Phosphatidylcholines 121-140 calcitonin-related polypeptide alpha Rattus norvegicus 21-31 8336521-2 1993 Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine. Phosphatidylcholines 211-230 C-reactive protein Homo sapiens 29-32 8336521-3 1993 In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered. Phosphatidylcholines 34-53 C-reactive protein Homo sapiens 221-224 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 172-191 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 172-191 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 193-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 193-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 38-41 1451798-3 1992 We demonstrate here that membrane cholesterol initiates the activation of phosphatidyl choline phospholipase D and phosphatidic acid thus generated promotes the activation of its phospholipase A2 in the presence of extraplatelet calcium. Phosphatidylcholines 74-94 phospholipase A2 group IB Homo sapiens 179-195 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 54-57 1334462-2 1992 Previous studies have demonstrated that M-CSF stimulation is associated with phosphatidylcholine (PC) hydrolysis and increased formation of both diacylglycerol (DAG) and phosphorylcholine. Phosphatidylcholines 98-100 colony stimulating factor 1 Homo sapiens 40-45 1447171-6 1992 Lifetime distribution centers for labeled lipids were very similar except for DPH-PC in Lp(a) which was shifted to longer lifetimes, suggesting a less polar environment of PC in Lp(a) than in LDL. Phosphatidylcholines 82-84 lipoprotein(a) Homo sapiens 88-93 1444461-9 1992 The three alpha-class GSTs of lung expressed glutathione peroxidase activities toward the hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, with Km values in the range of 22 to 87 microM and Vmax values in the range of 67-120 mol/mol/min, indicating the involvement of the alpha-class GSTs in the protection mechanisms against peroxidation. Phosphatidylcholines 108-127 glutathione S-transferase kappa 1 Homo sapiens 22-26 1444461-9 1992 The three alpha-class GSTs of lung expressed glutathione peroxidase activities toward the hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, with Km values in the range of 22 to 87 microM and Vmax values in the range of 67-120 mol/mol/min, indicating the involvement of the alpha-class GSTs in the protection mechanisms against peroxidation. Phosphatidylcholines 108-127 glutathione S-transferase kappa 1 Homo sapiens 326-330 1332854-3 1992 Anti-P450RAP immunoblots a protein present in ovarian and testicular microsomes that is the same size as P450RAP and which coelutes with the P450 fraction during chromatography on an immobilized artificial membrane column made with phosphatidylcholine. Phosphatidylcholines 232-251 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 5-12 1332854-3 1992 Anti-P450RAP immunoblots a protein present in ovarian and testicular microsomes that is the same size as P450RAP and which coelutes with the P450 fraction during chromatography on an immobilized artificial membrane column made with phosphatidylcholine. Phosphatidylcholines 232-251 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 105-112 1447171-0 1992 Organization of phosphatidylcholine and sphingomyelin in the surface monolayer of low density lipoprotein and lipoprotein(a) as determined by time-resolved fluorometry. Phosphatidylcholines 16-35 lipoprotein(a) Homo sapiens 110-124 1463444-0 1992 A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung. Phosphatidylcholines 65-84 phospholipase A2 group IB Rattus norvegicus 27-43 1334462-0 1992 Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2. Phosphatidylcholines 47-66 colony stimulating factor 1 Homo sapiens 0-36 1334462-0 1992 Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2. Phosphatidylcholines 47-66 phospholipase A2 group IB Homo sapiens 93-109 1334462-2 1992 Previous studies have demonstrated that M-CSF stimulation is associated with phosphatidylcholine (PC) hydrolysis and increased formation of both diacylglycerol (DAG) and phosphorylcholine. Phosphatidylcholines 77-96 colony stimulating factor 1 Homo sapiens 40-45 1334462-4 1992 The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity. Phosphatidylcholines 36-38 colony stimulating factor 1 Homo sapiens 124-129 1334462-4 1992 The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity. Phosphatidylcholines 36-38 phospholipase A2 group IVA Homo sapiens 143-171 1334462-4 1992 The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity. Phosphatidylcholines 36-38 phospholipase A2 group IVA Homo sapiens 173-178 1447319-10 1992 Analysis of the CDP-choline pathway of PC synthesis indicated that the regulatory enzyme, CTP:phosphorylcholine cytidylyltransferase, was stimulated about twofold by PDBu in cells having normal membrane, but not in PE-deficient cells. Phosphatidylcholines 39-41 cut-like homeobox 1 Rattus norvegicus 16-19 1333428-8 1992 The acid secretagogues histamine, gastrin, and carbamylcholine stimulated mucin synthesis and PC release. Phosphatidylcholines 94-96 gastrin Canis lupus familiaris 34-41 1459142-8 1992 Phospholipase A2 also stimulated PtdEtOH and diacylglycerol formation from exogenous PtdCho. Phosphatidylcholines 85-91 phospholipase A2 group IB Rattus norvegicus 0-16 1431912-2 1992 Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-110 1431912-2 1992 Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 112-115 1479295-0 1992 Continuous fluorescence assay for lecithin:cholesterol acyltransferase using a water-soluble phosphatidylcholine. Phosphatidylcholines 93-112 lecithin-cholesterol acyltransferase Homo sapiens 34-70 1429710-2 1992 The binding of human recombinant factor VIIa to recombinant human TF incorporated into vesicles containing phosphatidylcholine (TF/PC) or phosphatidylcholine/phosphatidylserine (TF/PCPS) was studied using the increased rate of H-D-phenylalanyl L-pipecoyl L-arginine p-nitroanilide (S2238) hydrolysis as a signal for the interaction. Phosphatidylcholines 107-126 coagulation factor III, tissue factor Homo sapiens 66-68 1479295-1 1992 A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution. Phosphatidylcholines 28-47 lecithin-cholesterol acyltransferase Homo sapiens 180-216 1479295-1 1992 A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution. Phosphatidylcholines 28-47 lecithin-cholesterol acyltransferase Homo sapiens 218-222 1479295-3 1992 In contrast to the reaction of LCAT with aggregated phosphatidylcholines, the reaction of DPybPC with LCAT was not significantly affected by anions, ionic strength, nor apolipoproteins, indicating that these are only effectors of the interfacial reaction. Phosphatidylcholines 52-72 lecithin-cholesterol acyltransferase Homo sapiens 31-35 1330325-0 1992 TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Phosphatidylcholines 28-47 tumor necrosis factor Homo sapiens 0-3 1330325-0 1992 TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Phosphatidylcholines 28-47 nuclear factor kappa B subunit 1 Homo sapiens 14-24 1446736-3 1992 Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway. Phosphatidylcholines 198-217 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 185-188 1429710-2 1992 The binding of human recombinant factor VIIa to recombinant human TF incorporated into vesicles containing phosphatidylcholine (TF/PC) or phosphatidylcholine/phosphatidylserine (TF/PCPS) was studied using the increased rate of H-D-phenylalanyl L-pipecoyl L-arginine p-nitroanilide (S2238) hydrolysis as a signal for the interaction. Phosphatidylcholines 138-157 coagulation factor III, tissue factor Homo sapiens 66-68 1331066-0 1992 Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Phosphatidylcholines 15-34 coagulation factor II, thrombin Homo sapiens 48-56 1369037-0 1992 Biomimetic metal-sorbing vesicles: Cd2+ uptake by phosphatidylcholine vesicles doped with ionophore A23187. Phosphatidylcholines 50-69 CD2 molecule Homo sapiens 35-38 1369037-1 1992 Unilamellar phosphatidylcholine vesicles, harboring the ionophore, A23187, in the bilayer and the water-soluble chelating agent, nitrilotriacetate, in the vesicle interior, rapidly sequester and concentrate Cd2+ from dilute aqueous solution. Phosphatidylcholines 12-31 CD2 molecule Homo sapiens 207-210 1331121-7 1992 PAF also stimulated PGE2 as well as 3H-arachidonic acid and 3H-lyso phosphatidylcholine (PtdCho) formation. Phosphatidylcholines 89-95 PCNA clamp associated factor Rattus norvegicus 0-3 1331121-8 1992 We suggest that arachidonate released specifically from PtdCho via phospholipase A2 is a source of this PAF-elevated PGE2. Phosphatidylcholines 56-62 phospholipase A2 group IB Rattus norvegicus 67-83 1331121-8 1992 We suggest that arachidonate released specifically from PtdCho via phospholipase A2 is a source of this PAF-elevated PGE2. Phosphatidylcholines 56-62 PCNA clamp associated factor Rattus norvegicus 104-107 1464752-8 1992 Although hepatic lipase hydrolyzes both triglycerides and phosphatidylcholines, elimination of the triolein from rHDL had no effect on the uptake of rHDL cholesteryl oleate, but replacement of the rHDL phosphatidylcholine with a nonhydrolyzable phosphatidylcholine diether resulted in an 87% reduction in cholesteryl oleate uptake. Phosphatidylcholines 58-78 lipase C, hepatic type Rattus norvegicus 9-23 1464752-8 1992 Although hepatic lipase hydrolyzes both triglycerides and phosphatidylcholines, elimination of the triolein from rHDL had no effect on the uptake of rHDL cholesteryl oleate, but replacement of the rHDL phosphatidylcholine with a nonhydrolyzable phosphatidylcholine diether resulted in an 87% reduction in cholesteryl oleate uptake. Phosphatidylcholines 58-77 lipase C, hepatic type Rattus norvegicus 9-23 1390776-12 1992 The phosphorylated annexin I also bound to 20% phosphatidylserine/80% phosphatidylcholine vesicles at lower Ca2+ levels than the native form. Phosphatidylcholines 70-89 annexin A1 Bos taurus 19-28 1400459-2 1992 We report here that immune complexes activate a phosphatidylcholine-specific phospholipase A in a neutrophil only after the cytoplasmic Ca2+ transient has been initiated in the same cell, while chemotactic peptide activation does not proceed via such a phospholipase A-mediated mechanism. Phosphatidylcholines 48-67 phospholipase A and acyltransferase 1 Homo sapiens 77-92 1400459-2 1992 We report here that immune complexes activate a phosphatidylcholine-specific phospholipase A in a neutrophil only after the cytoplasmic Ca2+ transient has been initiated in the same cell, while chemotactic peptide activation does not proceed via such a phospholipase A-mediated mechanism. Phosphatidylcholines 48-67 phospholipase A and acyltransferase 1 Homo sapiens 253-268 1400459-3 1992 Measurements of [Ca2+] changes and of phosphatidylcholine-specific phospholipase A activity were made by flow cytometry, using Indo-1 for Ca2+ indication, and a new fluorescent probe, bis-BODIPY-phosphatidylcholine, localized in the inner leaflet of the plasma membrane, to measure phospholipase A activation. Phosphatidylcholines 38-57 phospholipase A and acyltransferase 1 Homo sapiens 67-82 1390857-3 1992 Using the temperature-sensitive mutant strain Saccharomyces cerevisiae sec 14, which is defective in the phosphatidylinositol transfer protein, it could be demonstrated that this protein is not involved in the transport of phosphatidylinositol and phosphatidylcholine from internal membranes to the plasma membrane. Phosphatidylcholines 248-267 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 71-77 1431573-7 1992 These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions. Phosphatidylcholines 47-49 solute carrier family 38 member 3 Homo sapiens 114-118 1417792-0 1992 Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst. Phosphatidylcholines 131-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-32 1289236-6 1992 The presence of phosphatidylcholine and phosphatidylethanolamine in the culture medium also increased the secretion of apoB into the medium. Phosphatidylcholines 16-35 apolipoprotein B Rattus norvegicus 119-123 1431573-7 1992 These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions. Phosphatidylcholines 47-49 solute carrier family 38 member 3 Homo sapiens 175-179 1431573-7 1992 These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions. Phosphatidylcholines 47-49 solute carrier family 38 member 5 Homo sapiens 184-188 1390880-6 1992 These results show that the positional specificity of human plasma LCAT is altered in the presence of sn-2-arachidonoyl PC, or sn-2-docosahexaenoyl PC, probably due to steric restrictions at the active site, and this may account for the formation of disproportionately high concentrations of saturated CE, and low concentrations of long-chain polyunsaturated CE in human plasma, relative to the composition of sn-2-acyl groups in plasma PC. Phosphatidylcholines 120-122 lecithin-cholesterol acyltransferase Homo sapiens 67-71 1417822-0 1992 Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells. Phosphatidylcholines 30-49 angiotensinogen Homo sapiens 53-67 1418772-6 1992 Apolipoprotein A-I has been used as an example of a probe to estimate the effective surface pressure in approximately 1000 A diameter egg yolk phosphatidylcholine/cholesterol/triolein emulsion particles. Phosphatidylcholines 143-162 apolipoprotein A1 Homo sapiens 0-18 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. Phosphatidylcholines 31-50 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 80-99 interferon gamma Homo sapiens 219-228 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 80-99 phospholipase A2 group IB Homo sapiens 282-298 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 259-278 interferon gamma Homo sapiens 125-134 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 259-278 interferon gamma Homo sapiens 219-228 1387643-4 1992 Half-maximal inhibition of prothrombinase on and binding of annexin V to small vesicles, composed of 20% phosphatidylserine and 80% phosphatidylcholine, requires 2-3 mM calcium. Phosphatidylcholines 132-151 annexin A5 Homo sapiens 60-69 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 80-99 interferon gamma Homo sapiens 125-134 1390642-3 1992 Analysis of the intramolecular pyrene-pyrene collision data obtained for 30 such species in terms of a simple geometrical model showed that the sn-1 acyl chain penetrates, on the average, 0.84 +/- 0.11 methylene units (0.8 A) deeper into the bilayer than the sn-2 chain at 22 degrees C. A similar value was obtained at 37 degrees C. Since the penetration difference of the sn-1 and sn-2 acyl chains is inherently coupled to the conformation of the glycerol moiety, these data mean that the glycerol moiety of phosphatidylcholine is, on the average, only moderately tilted with respect to the bilayer plane in the liquid-crystalline state. Phosphatidylcholines 509-528 solute carrier family 38 member 3 Homo sapiens 144-148 1330154-8 1992 The onset of vasopressin-stimulated inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) mass formation preceded [3H]-PtdBuOH accumulation indicating that PtdCh hydrolysis was activated subsequent to PtdIns(4,5)P2 breakdown. Phosphatidylcholines 146-151 arginine vasopressin Homo sapiens 13-24 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. Phosphatidylcholines 52-54 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1402396-12 1992 Hydrolysis of phosphatidylcholine by hepatic lipase was threefold higher in A-II-containing HDL2 when compared with HDL2 devoid of apoA-II. Phosphatidylcholines 14-33 lipase C, hepatic type Homo sapiens 37-51 1402396-12 1992 Hydrolysis of phosphatidylcholine by hepatic lipase was threefold higher in A-II-containing HDL2 when compared with HDL2 devoid of apoA-II. Phosphatidylcholines 14-33 apolipoprotein A2 Homo sapiens 131-138 1512228-10 1992 From these data, we conclude that MDCK cells contain two PLD subtypes: 1) a membrane-associated, PC-selective enzyme that responds to TPA resulting in prolonged hydrolysis of PC (the PC-PLD is Ca(2+)-independent, but requires detergent); 2) a cytosolic, PI-selective enzyme that responds rapidly but transiently to bradykinin (the PI-PLD requires Ca2+ but not detergent). Phosphatidylcholines 97-99 kininogen 1 Canis lupus familiaris 315-325 1333103-1 1992 Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG). Phosphatidylcholines 88-107 HDL3 Homo sapiens 73-77 1333103-1 1992 Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG). Phosphatidylcholines 109-111 HDL3 Homo sapiens 73-77 1333103-2 1992 In (3H) PC prelabelled platelets, phosphocholine is released into the medium during HDL3 induced PC turnover with a 1.5 to 2 fold increment, indicating that HDL3 stimulated DAG generation in platelets is likely due to phospholipase C (PLC). Phosphatidylcholines 8-10 HDL3 Homo sapiens 157-161 1512242-5 1992 By using the MIANS moiety as a fluorescent reporter group, we were able to monitor directly the binding of the MIANS-beta gamma T complex to light-activated rhodopsin, which was reconstituted into phosphatidylcholine vesicles, through an enhancement (30-50%) in the MIANS fluorescence. Phosphatidylcholines 197-216 rhodopsin Homo sapiens 157-166 1508183-1 1992 A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Phosphatidylcholines 95-114 heparan sulfate proteoglycan 2 L homeolog Xenopus laevis 119-122 1504094-0 1992 Promotion of beta-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine. Phosphatidylcholines 92-111 islet amyloid polypeptide Homo sapiens 79-85 1324124-4 1992 Superoxide formation was evidenced by SOD-inhibitable cytochrome c reduction in the reaction of NTP with egg phosphatidylcholine at molar ratio 1:1, and 1:3. Phosphatidylcholines 109-128 superoxide dismutase 1 Homo sapiens 38-41 1387325-1 1992 The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated. Phosphatidylcholines 157-176 annexin A2 Bos taurus 87-97 1387325-1 1992 The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated. Phosphatidylcholines 157-176 LOC104974671 Bos taurus 121-137 1387325-1 1992 The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated. Phosphatidylcholines 157-176 LOC104974671 Bos taurus 139-143 1387325-1 1992 The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated. Phosphatidylcholines 178-180 LOC104974671 Bos taurus 139-143 1387325-5 1992 Despite a large excess of detergent, precipitates were, at times, observed upon incubation of some PC/DOC mixtures at 37 degrees C. Such behavior is of interest in view of the numerous reports of PLA2 inhibition by annexins and annexin-derived peptides in the PC/DOC system. Phosphatidylcholines 99-101 phospholipase A2 group IB Homo sapiens 196-200 1387686-1 1992 Low-angle neutron solution scattering has been used to study the structure of annexin-V and its interaction with small single-bilayer vesicles consisting of phosphatidylserine and phosphatidylcholine at a 33:66 (mol:mol) ratio. Phosphatidylcholines 180-199 annexin A5 Homo sapiens 78-87 1500722-5 1992 However, prolonged incubation with human rIL-1 beta (30 to 180 min) inhibited in a concentration- and time-dependent manner the release of AA and the hydrolysis of phosphatidylcholine in ionophore-stimulated eosinophils. Phosphatidylcholines 164-183 interleukin 1 beta Rattus norvegicus 41-51 1510717-0 1992 In human monocytes interleukin-1 stimulates a phospholipase C active on phosphatidylcholine and inactive on phosphatidylinositol. Phosphatidylcholines 72-91 interleukin 1 alpha Homo sapiens 19-32 1510717-3 1992 Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC. Phosphatidylcholines 95-114 phospholipase A2 group IB Homo sapiens 46-62 1510717-3 1992 Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC. Phosphatidylcholines 95-114 phospholipase A2 group IB Homo sapiens 64-68 1510717-3 1992 Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC. Phosphatidylcholines 116-118 phospholipase A2 group IB Homo sapiens 46-62 1510717-3 1992 Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC. Phosphatidylcholines 116-118 phospholipase A2 group IB Homo sapiens 64-68 1510717-9 1992 In contrast, in cells labeled with [3H]AA, IL-1 causes the formation of DAG associated with the hydrolysis of PC. Phosphatidylcholines 110-112 interleukin 1 alpha Homo sapiens 43-47 1324124-4 1992 Superoxide formation was evidenced by SOD-inhibitable cytochrome c reduction in the reaction of NTP with egg phosphatidylcholine at molar ratio 1:1, and 1:3. Phosphatidylcholines 109-128 cytochrome c, somatic Homo sapiens 54-66 1323272-0 1992 Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells. Phosphatidylcholines 90-109 arginine vasopressin Homo sapiens 25-36 1323272-1 1992 The kinetics of vasopressin-stimulated PtdIns(4,5)P2 and phosphatidylcholine (PtdCho) hydrolysis in relation to sustained diacylglycerol (DAG) formation was investigated in A10 vascular-smooth-muscle cells in culture. Phosphatidylcholines 57-76 arginine vasopressin Homo sapiens 16-27 1323272-1 1992 The kinetics of vasopressin-stimulated PtdIns(4,5)P2 and phosphatidylcholine (PtdCho) hydrolysis in relation to sustained diacylglycerol (DAG) formation was investigated in A10 vascular-smooth-muscle cells in culture. Phosphatidylcholines 78-84 arginine vasopressin Homo sapiens 16-27 1323272-7 1992 Vasopressin stimulated an increase in formation of choline, but not of phosphocholine, suggesting that PLD was the major catalytic route of PtdCho hydrolysis in this cell line. Phosphatidylcholines 140-146 arginine vasopressin Homo sapiens 0-11 1323272-7 1992 Vasopressin stimulated an increase in formation of choline, but not of phosphocholine, suggesting that PLD was the major catalytic route of PtdCho hydrolysis in this cell line. Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 1627557-5 1992 We show that when the PI is sufficiently dispersed by dilution with PC, it inhibits microtubule assembly by binding to MAP2 with an apparent stoichiometry, after correction for the bilamellar nature of the liposomes, of 1:1 mol.mol-1 PI:MAP2. Phosphatidylcholines 68-70 microtubule associated protein 2 Homo sapiens 119-123 1643097-0 1992 Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 104-123 LOC104974671 Bos taurus 17-33 1643097-8 1992 There was a clear preference for PC peroxidation for all vesicle compositions tested and PC was preferentially hydrolyzed by PLA2. Phosphatidylcholines 89-91 LOC104974671 Bos taurus 125-129 1631141-7 1992 The results suggest that cis-unsaturated fatty acids, which are presumably produced from phosphatidylcholine by signal-dependent activation of phospholipase A2, may take part directly in cell signaling through the protein kinase C pathway. Phosphatidylcholines 89-108 phospholipase A2 group IB Homo sapiens 143-159 1627547-0 1992 Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase A2. Phosphatidylcholines 102-122 phospholipase A2 group IB Homo sapiens 126-142 1637307-0 1992 Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis. Phosphatidylcholines 103-122 epidermal growth factor Mus musculus 0-23 1322489-7 1992 Digestion of control heart sarcolemma with phospholipase A2 inhibited Ca2+ transport and the inhibition was reversible by phosphatidylcholine. Phosphatidylcholines 122-141 phospholipase A2 group IB Canis lupus familiaris 43-59 1637948-9 1992 It is proposed that PAF induces PC hydrolysis as a consequence of an early phospholipase D-catalyzed breakdown of PC in human secretory endometrium. Phosphatidylcholines 32-34 PCNA clamp associated factor Homo sapiens 20-23 1637948-0 1992 Platelet-activating factor mediates phosphatidylcholine hydrolysis by phospholipase D in human endometrium. Phosphatidylcholines 36-55 PCNA clamp associated factor Homo sapiens 0-26 1637948-2 1992 The mechanism of phosphatidylcholine (PC) degradation stimulated by PAF was investigated in endometrial explants prelabeled with [methyl-3H]choline or preincubated with [3H]butan-1-ol. Phosphatidylcholines 17-36 PCNA clamp associated factor Homo sapiens 68-71 1637948-2 1992 The mechanism of phosphatidylcholine (PC) degradation stimulated by PAF was investigated in endometrial explants prelabeled with [methyl-3H]choline or preincubated with [3H]butan-1-ol. Phosphatidylcholines 38-40 PCNA clamp associated factor Homo sapiens 68-71 1419482-2 1992 At 1 U/ml, phosphatidylcholine-specific phospholipase C increases DAG, alters intracellular pH and inhibits the induction of meiosis by insulin or progesterone. Phosphatidylcholines 11-30 insulin S homeolog Xenopus laevis 136-143 1315771-0 1992 Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Phosphatidylcholines 48-67 protein kinase C, beta Rattus norvegicus 82-105 1377491-0 1992 Binding of substance P to monolayers and vesicles made of phosphatidylcholine and/or phosphatidylserine. Phosphatidylcholines 58-77 tachykinin precursor 1 Homo sapiens 11-22 1377491-3 1992 Injection of SP into the aqueous subphase led to an expansion of phosphatidylcholine (PtdCho) or phosphatidylserine (PtdSer) monolayer surface area. Phosphatidylcholines 65-84 tachykinin precursor 1 Homo sapiens 13-15 1377491-3 1992 Injection of SP into the aqueous subphase led to an expansion of phosphatidylcholine (PtdCho) or phosphatidylserine (PtdSer) monolayer surface area. Phosphatidylcholines 86-92 tachykinin precursor 1 Homo sapiens 13-15 1387413-0 1992 Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position. Phosphatidylcholines 73-92 lecithin-cholesterol acyltransferase Homo sapiens 14-50 1387413-6 1992 The purpose of the present study was to directly test the influence of eicosapentaenoic acid (20:5 n-3) and docosahexaenoic acid (22:6 n-3) in the sn-2 position of phosphatidylcholine (PC) on the activity of LCAT. Phosphatidylcholines 164-183 lecithin-cholesterol acyltransferase Homo sapiens 208-212 1434119-1 1992 Recombinant human tumor necrosis factor-beta (rhTNF-beta) may be encapsulated with high efficiency in phosphatidylcholine and distearoylphosphatidylcholine liposomes, with entrapment values of 93.4% and 92.3%, respectively, by first entrapping the substance in multilamellar vesicles using a high solute-to-phospholipid ratio followed by freeze-drying and then rehydration. Phosphatidylcholines 102-121 lymphotoxin alpha Homo sapiens 18-44 1596521-3 1992 Phospholipid transfer proteins I and III transferred phosphatidylcholine (PC) and phosphatidylinositol (PI) from donor unilamellar liposomes to acceptor multilamellar liposomes; protein II transferred PC but not PI. Phosphatidylcholines 53-72 annexin A4 Homo sapiens 178-188 1577735-3 1992 We therefore used a surface balance and surface radioactivity detector to investigate the adsorption of apoA-IV to egg phosphatidylcholine monolayers spread at the air/water interface. Phosphatidylcholines 119-138 apolipoprotein A4 Homo sapiens 104-111 1566749-3 1992 Since PAF-AH is also known to hydrolyze oxidized derivatives of phosphatidylcholine and since RBCs are not effector cells of PAF, the observed activity in RBC membranes may play a potential role in degrading oxidation products of membrane phospholipids. Phosphatidylcholines 64-83 phospholipase A2 group VII Homo sapiens 6-12 1376049-1 1992 About half of the phosphatidylcholine (PtC)-binding peritoneal B cells of B10.H-2aH-4bp/Wts mice express the VH12 gene. Phosphatidylcholines 39-42 immunoglobulin heavy chain (V12 family) Mus musculus 109-113 1376071-0 1992 Characterization of expanded populations of peritoneal CD5 B cells specific for phosphatidyl choline in old B10.H-2aH-4bp/Wts mice. Phosphatidylcholines 80-100 CD5 antigen Mus musculus 55-58 1376049-1 1992 About half of the phosphatidylcholine (PtC)-binding peritoneal B cells of B10.H-2aH-4bp/Wts mice express the VH12 gene. Phosphatidylcholines 18-37 immunoglobulin heavy chain (V12 family) Mus musculus 109-113 1421279-3 1992 Specific activity of control phosphatidylcholine was about 15-fold higher than that of phosphatidylcholine from tert-butyl hydroperoxide-treated cells. Phosphatidylcholines 87-106 telomerase reverse transcriptase Mus musculus 112-116 1590762-5 1992 The synthesis of phosphatidylcholine was dependent on addition of CDP-choline. Phosphatidylcholines 17-36 cut-like homeobox 1 Rattus norvegicus 66-69 1320459-2 1992 During the period of induction, both insulin and progesterone induced an increase in 32PO4 labeling of phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 103-122 insulin S homeolog Xenopus laevis 37-44 1323686-6 1992 The 17-amino acid HA2 peptide (HA2.17) destabilized phosphatidylcholine (PC) vesicles even at neutral pH, but the rate and extent of destabilization increased at lower pH. Phosphatidylcholines 52-71 myosin IG Homo sapiens 18-21 1510877-0 1992 v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis. Phosphatidylcholines 63-82 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 2-5 1323686-6 1992 The 17-amino acid HA2 peptide (HA2.17) destabilized phosphatidylcholine (PC) vesicles even at neutral pH, but the rate and extent of destabilization increased at lower pH. Phosphatidylcholines 52-71 myosin IG Homo sapiens 31-34 1315360-6 1992 Finally, direct measurement of enzymatic activity in vitro using radiolabeled phospholipid vesicles showed that CD69 cross-linking resulted in PLA2-dependent arachidonic acid and lysophosphatidylcholine generation from phosphatidylcholine, which was sensitive to quinacrine but not to R68070. Phosphatidylcholines 183-202 CD69 molecule Homo sapiens 112-116 19431824-6 1992 The bilayer transition temperatures of saturated asymmetrical phosphatidylcholines are interpreted by assuming that the transition enthalpy and transition entropy are linearly related to the absolute value of the difference in chain length between the sn-1 and sn-2 chains, with constant end contributions. Phosphatidylcholines 62-82 solute carrier family 38 member 3 Homo sapiens 252-265 1315360-6 1992 Finally, direct measurement of enzymatic activity in vitro using radiolabeled phospholipid vesicles showed that CD69 cross-linking resulted in PLA2-dependent arachidonic acid and lysophosphatidylcholine generation from phosphatidylcholine, which was sensitive to quinacrine but not to R68070. Phosphatidylcholines 183-202 phospholipase A2 group IB Homo sapiens 143-147 1581336-1 1992 The interactions of salmon calcitonin with glycosphingolipid sulfatide are studied by right angle light scattering from the lipid suspension, by the excimer to monomer ratio (E/M) of the fluorescence intensity of pyrene phosphatidylcholine and pyrene sulfatide and by the leakage of carboxyfluorescein. Phosphatidylcholines 220-239 calcitonin related polypeptide alpha Homo sapiens 27-37 1533163-1 1992 The selectivity of phospholipase A2 from serum was evaluated using radioassays and mass analyses of fatty acids liberated from phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 127-146 phospholipase A2 group IB Homo sapiens 19-35 1304354-2 1992 Three vitamin K-dependent proteins (factor X, protein Z, and prothrombin) dissociated from small unilamellar vesicles (SUVs, 30 nm diameter) composed of 25% phosphatidylserine (PS) and 75% phosphatidylcholine (PC) at comparable pressures (midpoints of 0.3-0.6 kbar). Phosphatidylcholines 210-212 coagulation factor II, thrombin Homo sapiens 36-72 1623574-3 1992 Also a decreased [32P]phosphatidylcholine and an increased [32P]lysophosphatidylcholine labeling were observed, suggesting an increased activity of phosphatidylcholine-specific phospholipase A2. Phosphatidylcholines 22-41 phospholipase A2 group IB Rattus norvegicus 177-193 1355578-0 1992 Relationship between translocation of long-chain acyl-CoA hydrolase, phosphatidate phosphohydrolase and CTP:phosphocholine cytidylyltransferase and the synthesis of triglycerides and phosphatidylcholine in rat liver. Phosphatidylcholines 183-202 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 104-143 1576162-4 1992 In recent years the fluorescent analogue of phosphatidylcholine, C6-NBD-PC, has been used for determination of the activity of soluble and membrane-bound PLA2. Phosphatidylcholines 44-63 phospholipase A2 group IB Homo sapiens 154-158 1537086-4 1992 In sharp contrast, human mitochondrial phospholipase A2 1) accounts for only a diminutive amount of total myocardial phospholipase A2 activity (1-2%), 2) is augmented by calcium ion, 3) exhibits a higher reaction velocity using phosphatidylcholine in comparison with plasmenylcholine substrate, and 4) is not substantially inhibited by either DTNB or bromoenol lactone. Phosphatidylcholines 228-247 phospholipase A2 group IB Homo sapiens 39-55 1532578-0 1992 Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells. Phosphatidylcholines 71-90 phospholipase A2, group IB, pancreas Mus musculus 44-60 1532578-4 1992 The corresponding production of lysophosphatidylcholine suggested the involvement of a phosphatidylcholine-specific phospholipase A2. Phosphatidylcholines 36-55 phospholipase A2, group IB, pancreas Mus musculus 116-132 1532578-6 1992 These data strongly suggest that occupation of the bombesin receptor is closely coupled to activation of phospholipase A2 which results in the rapid release of arachidonic acid from phosphatidylcholine. Phosphatidylcholines 182-201 phospholipase A2, group IB, pancreas Mus musculus 105-121 1311313-4 1992 Acetylation of bovine fragment 1 in the absence of Ca(II) or Mg(II) ions results in the loss of the metal ion-promoted quenching of the intrinsic Trp fluorescence of the protein and the Ca(II)-mediated binding to phosphatidylserine/phosphatidylcholine (PS/PC) vesicles. Phosphatidylcholines 232-251 carbonic anhydrase 2 Bos taurus 186-192 1540589-8 1992 The hydrolysis of HDL-I phosphatidylcholine was approximately 3-fold higher than HDL-II, supporting the hypothesis that HL preferably hydrolyzes the phospholipids in apoE-rich HDL. Phosphatidylcholines 24-43 apolipoprotein E Homo sapiens 166-170 1563569-1 1992 Phospholipase A2 activity (EC 3.1.1.4) was estimated in low-speed supernatants of human placenta by measuring the release of arachidonic acid from phosphatidylcholine, 1-stearoyl-2-[3H]arachidonyl and other phospholipids under alkaline conditions (pH 8). Phosphatidylcholines 147-166 phospholipase A2 group IB Homo sapiens 0-16 1348227-6 1992 In conclusion, both beta 1- and beta 2-adrenoceptor subtypes mediate phosphatidylcholine secretion in rat type II pneumocytes. Phosphatidylcholines 69-88 adrenoceptor beta 1 Rattus norvegicus 20-51 1311959-9 1992 These findings suggest that the increase in PGI2 release elicited by ATP and UTP is at least partially dependent upon a phospholipase C-mediated increase in [Ca2+]i and the subsequent activation of a phosphatidylcholine-specific phospholipase A2. Phosphatidylcholines 200-219 LOC104974671 Bos taurus 229-245 1736998-0 1992 Lateral interactions of pig apolipoprotein A-1 with egg yolk phosphatidylcholine and with cholesterol in mixed monolayers at the triolein-saline interface. Phosphatidylcholines 61-80 apolipoprotein A1 Sus scrofa 28-46 1311563-6 1992 Annexin-V induced a decrease of 70% of thrombomodulin activity when thrombomodulin (5.4-214 nM) was reconstituted into phosphatidylcholine/phosphatidylserine (1:1, mol/mol) vesicles at 37.5 or 75 microM-phospholipid concentration, the apparent Ki being 0.5 microM at 75 microM-lipid. Phosphatidylcholines 119-138 annexin A5 Homo sapiens 0-9 1736998-6 1992 The large difference in lateral interaction energy with apoA-1 between PC and cholesterol in a mixed monolayer is discussed in connection with current problems in lipoprotein catabolism: reverse cholesterol transport, alterations in affinity of lipid particles to apoA-1, and formation of high-density lipoproteins and abnormal lipoproteins. Phosphatidylcholines 71-73 apolipoprotein A1 Sus scrofa 56-62 1736998-6 1992 The large difference in lateral interaction energy with apoA-1 between PC and cholesterol in a mixed monolayer is discussed in connection with current problems in lipoprotein catabolism: reverse cholesterol transport, alterations in affinity of lipid particles to apoA-1, and formation of high-density lipoproteins and abnormal lipoproteins. Phosphatidylcholines 71-73 apolipoprotein A1 Sus scrofa 264-270 1543719-5 1992 This change in Cdl was sensitive enough to monitor the course of enzymatic hydrolysis of the PC monolayer by PLD. Phosphatidylcholines 93-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 1531960-3 1992 The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway. Phosphatidylcholines 23-42 hepatocyte growth factor Rattus norvegicus 4-7 1531960-3 1992 The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway. Phosphatidylcholines 44-46 hepatocyte growth factor Rattus norvegicus 4-7 1539683-0 1992 Vasopressin and phorbol ester-stimulated phosphatidylcholine metabolism in mesangial cells. Phosphatidylcholines 41-60 arginine vasopressin Rattus norvegicus 0-11 1539683-1 1992 We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells. Phosphatidylcholines 115-134 arginine vasopressin Rattus norvegicus 95-106 1539683-1 1992 We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells. Phosphatidylcholines 115-134 arginine vasopressin Rattus norvegicus 108-110 1539683-2 1992 PMA and VP stimulate the incorporation of [3H]choline into phosphatidylcholine and the release of [3H]choline into the culture medium. Phosphatidylcholines 59-78 arginine vasopressin Rattus norvegicus 8-10 1539683-6 1992 A dual labeling study ([3H]myristic acid and [14C]arachidonic acid) suggests that phosphatidylcholine is an important source of diacylglycerol in cells treated with VP and PMA. Phosphatidylcholines 82-101 arginine vasopressin Rattus norvegicus 165-167 1541325-2 1992 In contrast, in cells labelled with [3H]myristic acid, a tracer that preferentially marks phosphatidylcholine, angiotensin II induced a delayed monophasic production of 1,2-diacylglycerol. Phosphatidylcholines 90-109 angiotensinogen Rattus norvegicus 111-125 1579054-1 1992 This report examines the distribution of n-3 and n-6 fatty acids in heart, kidney and liver phosphatidylcholine and phosphatidylethanolamine of suckling mice from dams fed a fat-supplemented diet with variable n-3/n-6 ratios. Phosphatidylcholines 92-111 notch 3 Mus musculus 41-44 1569706-0 1992 [The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini (II)]. Phosphatidylcholines 45-64 cholecystokinin Rattus norvegicus 26-41 1569706-1 1992 To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini. Phosphatidylcholines 97-116 cholecystokinin Rattus norvegicus 72-87 1569706-1 1992 To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini. Phosphatidylcholines 97-116 cholecystokinin Rattus norvegicus 89-92 1309795-12 1992 In another approach, the diacylglycerol levels were increased by an inhibitor of diacylglycerol lipase (U-57908) which also reversed the cAMP effects on diacylglycerol levels and phosphatidylcholine biosynthesis. Phosphatidylcholines 179-198 lipase G, endothelial type Rattus norvegicus 96-102 1309795-14 1992 Instead, phosphatidylcholine biosynthesis appears to be inhibited due to a decreased level of diacylglycerol, a substrate for CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. Phosphatidylcholines 9-28 cut-like homeobox 1 Rattus norvegicus 126-129 1623116-7 1992 The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation. Phosphatidylcholines 46-65 heparan sulfate proteoglycan 2 Homo sapiens 149-152 1623116-7 1992 The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 1569041-1 1992 Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate. Phosphatidylcholines 171-190 phospholipase A2 group IB Rattus norvegicus 0-16 1569041-1 1992 Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate. Phosphatidylcholines 192-194 phospholipase A2 group IB Rattus norvegicus 0-16 1569706-1 1992 To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini. Phosphatidylcholines 118-120 cholecystokinin Rattus norvegicus 89-92 1569706-5 1992 This inhibition of PC synthesis induced by CCK was accompanied by a delayed disappearance of [3H] diacylglycerol (DAG), the radioactivity of which was 225% of control at 60 min. Phosphatidylcholines 19-21 cholecystokinin Rattus norvegicus 43-46 1569706-7 1992 These results suggest that CCK inhibits PC synthesis by inducing the inhibition of CTP: phosphocholine cytidylyltransferase activity. Phosphatidylcholines 40-42 cholecystokinin Rattus norvegicus 27-30 1569706-7 1992 These results suggest that CCK inhibits PC synthesis by inducing the inhibition of CTP: phosphocholine cytidylyltransferase activity. Phosphatidylcholines 40-42 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 83-123 1569706-8 1992 The inhibition by CCK of PC synthesis may contribute to the sustained accumulation of DAG in pancreatic acinar cells. Phosphatidylcholines 25-27 cholecystokinin Rattus norvegicus 18-21 1317973-7 1992 The results suggest that the decreased binding sites of beta-adrenoceptor in lung tissue of rat during hyperthermia may be contributed to the activation of PLA2, which then accelerated the catabolism of phospholipids such as PC and PS in the cell plasma membrane, with a consequent alteration of membrane fluidity. Phosphatidylcholines 225-227 phospholipase A2 group IB Rattus norvegicus 156-160 1730636-4 1992 This effect could be entirely reproduced by incubation with phosphatidylcholine vesicles which increased apoE accumulation in the medium by 2-6-fold. Phosphatidylcholines 60-79 apolipoprotein E Homo sapiens 105-109 1731954-4 1992 We studied the effects of EGF on the incorporation of glycerol into lamellar body disaturated phosphatidylcholine (DSPC) in sex-specific fetal rabbit lung explants prepared at 21 and 24 days gestation (term 31 days). Phosphatidylcholines 94-113 pro-epidermal growth factor Oryctolagus cuniculus 26-29 1541325-3 1992 This delayed peak of 1,2-diacylglycerol generation was associated with a concomitant increase in choline formation, suggesting that stimulation of mesangial cells with angiotensin II causes a phospholipase D-mediated phosphatidylcholine hydrolysis. Phosphatidylcholines 217-236 angiotensinogen Rattus norvegicus 168-182 1541325-7 1992 These data clearly indicate that angiotensin II AT1 receptors trigger phospholipase D-mediated phosphatidylcholine hydrolysis in rat mesangial cells. Phosphatidylcholines 95-114 angiotensinogen Rattus norvegicus 33-47 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. Phosphatidylcholines 291-310 phospholipase A2, group IB, pancreas Mus musculus 0-16 1323204-11 1992 These data suggest that PKC may act as a switch, terminating inositol phospholipid hydrolysis and activating the hydrolysis of phosphatidylcholine. Phosphatidylcholines 127-146 proline rich transmembrane protein 2 Homo sapiens 24-27 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. Phosphatidylcholines 312-314 phospholipase A2, group IB, pancreas Mus musculus 0-16 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phosphatidylcholines 103-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-147 1462844-0 1992 Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts. Phosphatidylcholines 58-77 Kirsten rat sarcoma viral oncogene homolog Mus musculus 91-96 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phosphatidylcholines 103-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 149-152 1727727-8 1992 These findings demonstrate for the first time that a physiological nutrient activates a phospholipase directed against endogenous phosphatidylcholine in intact islet cells; furthermore, they indicate a role for PLD in a delayed formation of phosphatidic acid in the islet cell. Phosphatidylcholines 130-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 211-214 1662619-4 1991 Three lines of evidence indicate phospholipase A2 activity to be involved in arachidonic acid release: (a) its inhibition by mepacrine, (b) the concomitant generation of lysophosphatidylcholine from [3H]choline-labeled cells and (c) an increase in arachidonic acid release from 14C-labeled phosphatidylcholine in particulate fractions from PMA-treated and bradykinin-treated keratinocytes. Phosphatidylcholines 174-193 phospholipase A2, group IB, pancreas Mus musculus 33-49 1309592-0 1992 Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Phosphatidylcholines 39-58 transforming growth factor beta 1 Homo sapiens 74-107 1299136-3 1992 Phospholipid analysis revealed that 1-O-alkyl-2-acyl-sn-glycerophosphocholine, a stored form of PAF precursor, accounted for 61.4% of the choline glycerophospholipids. Phosphatidylcholines 138-166 PCNA clamp associated factor Homo sapiens 96-99 1659906-7 1991 These data are consistent with the hypothesis that PA produced through the hydrolysis of PC by PLD is an important mediator of O2- production in response to receptor-dependent agonists. Phosphatidylcholines 89-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-98 1660466-5 1991 Here we show that eluates of antiphosphotyrosine affinity purified lysates of colony-stimulating factor 1-stimulated cells contain elevated levels of phosphatidylcholine-specific phospholipase C activity. Phosphatidylcholines 150-169 colony stimulating factor 1 Homo sapiens 78-105 1744125-3 1991 Purified betaglycan has properties similar to betaglycan affinity-labeled in intact cells: it binds TGF-beta 1 and TGF-beta 2 with KD approximately 0.2 nM, contains heparan sulfate and chondroitin sulfate glycosaminoglycan (GAG) chains and N-linked glycans attached to a 110-kDa core protein, and can spontaneously associate with phosphatidylcholine liposomes. Phosphatidylcholines 330-349 transforming growth factor beta receptor 3 Rattus norvegicus 9-19 1796676-3 1991 In the first hour after antigen challenge with 0.5 mg nematode AChE there was a very sharp rise in Ch mainly from agonist-stimulated and phospholipase mediated phosphatidylcholine (PC) breakdown. Phosphatidylcholines 160-179 acetylcholinesterase Bos taurus 63-67 1796676-3 1991 In the first hour after antigen challenge with 0.5 mg nematode AChE there was a very sharp rise in Ch mainly from agonist-stimulated and phospholipase mediated phosphatidylcholine (PC) breakdown. Phosphatidylcholines 181-183 acetylcholinesterase Bos taurus 63-67 1756867-6 1991 Phosphatidylcholine in mast cell membranes was appreciably hydrolyzed to liberate free arachidonic acid when mast cells were incubated with 14-kDa group II phospholipase A2 added exogenously in the presence of the antigen. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 156-172 1667458-1 1991 We have developed an assay to measure the affinity of serum vitamin D binding protein for 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and vitamin D3, using uniform diameter (6.4 microns) polystyrene beads coated with phosphatidylcholine and vitamin D metabolites as the vitamin D donor. Phosphatidylcholines 221-240 GC vitamin D binding protein Homo sapiens 60-85 1667458-4 1991 Phosphatidylcholine/vitamin D metabolite-coated beads (1 microM vitamin D metabolite) were incubated with varying concentrations of serum vitamin D binding protein under conditions in which the bead surfaces were saturated with protein, but most of the protein was free in solution. Phosphatidylcholines 0-19 GC vitamin D binding protein Homo sapiens 138-163 1787343-6 1991 After TNF stimulation, the level of phosphatidylcholine (PC) decreased. Phosphatidylcholines 36-55 tumor necrosis factor Homo sapiens 6-9 1787343-6 1991 After TNF stimulation, the level of phosphatidylcholine (PC) decreased. Phosphatidylcholines 57-59 tumor necrosis factor Homo sapiens 6-9 1787343-7 1991 Concomitantly, phospholipase A2 (PLA2) hydrolyzed PC producing a transiently increased level of lysophosphatidylcholine. Phosphatidylcholines 50-52 phospholipase A2 group IB Homo sapiens 15-31 1787343-7 1991 Concomitantly, phospholipase A2 (PLA2) hydrolyzed PC producing a transiently increased level of lysophosphatidylcholine. Phosphatidylcholines 50-52 phospholipase A2 group IB Homo sapiens 33-37 1657994-0 1991 Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini. Phosphatidylcholines 25-44 cholecystokinin Rattus norvegicus 0-15 1657994-7 1991 Furthermore, W-7 or W-5, a calmodulin antagonist, reversed the inhibition by CCK8 of PC synthesis, suggesting that a Ca(2+)-calmodulin-dependent pathway may be involved in CCK-induced inhibition of PC synthesis in acini. Phosphatidylcholines 85-87 cholecystokinin Rattus norvegicus 77-80 1657994-7 1991 Furthermore, W-7 or W-5, a calmodulin antagonist, reversed the inhibition by CCK8 of PC synthesis, suggesting that a Ca(2+)-calmodulin-dependent pathway may be involved in CCK-induced inhibition of PC synthesis in acini. Phosphatidylcholines 198-200 cholecystokinin Rattus norvegicus 77-80 1657994-10 1991 The analysis of enzyme activity involved in PC synthesis via CDP-choline pathway showed that CCK treatment of acini reduced CTP:phosphocholine cytidylyltransferase activity in both cytosolic and particulate fraction, a finding consistent with the delayed disappearance of phosphocholine induced by CCK in pulse-chase study. Phosphatidylcholines 44-46 cholecystokinin Rattus norvegicus 93-96 1657994-10 1991 The analysis of enzyme activity involved in PC synthesis via CDP-choline pathway showed that CCK treatment of acini reduced CTP:phosphocholine cytidylyltransferase activity in both cytosolic and particulate fraction, a finding consistent with the delayed disappearance of phosphocholine induced by CCK in pulse-chase study. Phosphatidylcholines 44-46 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 124-163 1657994-15 1991 This inhibition of PC synthesis induced by CCK was accompanied by a delayed disappearance of [3H]diacylglycerol, the radioactivity of which was 225% of control at 60 min. Phosphatidylcholines 19-21 cholecystokinin Rattus norvegicus 43-46 1657994-16 1991 These results indicate that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP:phosphocholine cytidylyltransferase activity. Phosphatidylcholines 41-43 cholecystokinin Rattus norvegicus 28-31 1657994-16 1991 These results indicate that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP:phosphocholine cytidylyltransferase activity. Phosphatidylcholines 41-43 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 136-175 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 48-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 48-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 69-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 69-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 1932100-6 1991 Phosphatidylcholine accounted for 84.8% of the phospholipids copurified with SP-D. Phosphatidylcholines 0-19 surfactant protein D Rattus norvegicus 77-81 1774014-3 1991 1) Influence of modified membrane cholesterol contents on insulin binding to erythrocytes (in vitro experiments): The cholesterol content of human erythrocyte membranes was modified by incubating the cells with phosphatidylcholine/cholesterol and phosphatidylcholine vesicles. Phosphatidylcholines 211-230 insulin Homo sapiens 58-65 1655413-0 1991 Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis. Phosphatidylcholines 66-85 heparan sulfate proteoglycan 2 L homeolog Xenopus laevis 174-177 1655413-0 1991 Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis. Phosphatidylcholines 66-85 heparan sulfate proteoglycan 2 L homeolog Xenopus laevis 226-229 1655413-0 1991 Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis. Phosphatidylcholines 202-221 heparan sulfate proteoglycan 2 L homeolog Xenopus laevis 174-177 1655413-0 1991 Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis. Phosphatidylcholines 202-221 heparan sulfate proteoglycan 2 L homeolog Xenopus laevis 226-229 1954254-1 1991 Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae. Phosphatidylcholines 220-239 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 118-122 1954254-1 1991 Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae. Phosphatidylcholines 220-239 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 127-131 1954254-9 1991 This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway. Phosphatidylcholines 99-118 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 44-48 1954254-9 1991 This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway. Phosphatidylcholines 99-118 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 58-62 1774014-6 1991 Phosphatidylcholine spin probe showed a dual effect of cholesterol on membrane fluidity, fluidizing below but rigidifying membranes above 20 degrees C. It is suggested that membrane cholesterol affects insulin receptor behavior through alteration of membrane fluidity, depending on the phase state of the membranes. Phosphatidylcholines 0-19 insulin Homo sapiens 202-209 1918982-6 1991 Stimulation of quiescent cells with IL-3 produced an acute increase in the mass of both alkylacylglycerol and diacylglycerol, consistent with phosphatidylcholine as a significant source. Phosphatidylcholines 142-161 interleukin 3 Mus musculus 36-40 1658188-6 1991 Further extensive examination of changes in metabolically labeled phospholipids indicated that TNF-stimulated hydrolysis of PC is accompanied by the generation of phosphorylcholine and DAG. Phosphatidylcholines 124-126 tumor necrosis factor Homo sapiens 95-98 1961199-7 1991 Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding. Phosphatidylcholines 42-61 perforin 1 Homo sapiens 124-133 1961199-7 1991 Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding. Phosphatidylcholines 42-61 perforin 1 Homo sapiens 233-242 1659382-4 1991 PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 37-43 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 204-219 1659382-4 1991 PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 37-43 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 221-224 1659382-8 1991 Down-regulation of protein kinase C (PKC), by pre-treatment with phorbol 12-myristate 13-acetate, abolished both [3H]choline and [3H]PtdBut formation, suggesting that PLD-catalysed PtdCho hydrolysis may be dependent on PKC activation, supporting its dependence on prior PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 181-187 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 167-170 1655762-8 1991 Similarly, egg yolk phosphatidylcholine complexes containing CF4 (CF4.egg PC) showed higher affinity binding than CF1-egg yolk phosphatidylcholine complexes confirming the results obtained with DMPC complexes. Phosphatidylcholines 127-146 Cardiac cell morphology QTL 1 Rattus norvegicus 114-117 1748624-6 1991 Deletion experiments evidenced the prominent role of pyruvate, transferrin, and selenium in the stimulation of surfactant PC biosynthesis. Phosphatidylcholines 122-124 transferrin Homo sapiens 63-74 1783615-12 1991 The isoforms nsLTP-A, -B, -C, and -D showed similar transfer activity not only for phosphatidylcholine and phosphatidylethanolamine but also for monogalactosyldiacylglycerol, although the homology among their amino acid sequences ranged from 70 to 30%. Phosphatidylcholines 83-102 non-specific lipid-transfer protein C, cotyledon-specific isoform-like Ricinus communis 13-36 1816683-1 1991 Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates. Phosphatidylcholines 177-197 phospholipase A2 group IB Rattus norvegicus 0-16 1816683-1 1991 Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates. Phosphatidylcholines 199-201 phospholipase A2 group IB Rattus norvegicus 0-16 1936266-4 1991 We found that IL3 stimulated the formation of diacylglycerol independently of inositol lipid turnover, but concomitantly with increased turnover of phosphatidylcholine. Phosphatidylcholines 148-167 interleukin 3 Mus musculus 14-17 1918982-10 1991 These results indicate a role for DG, generated through the hydrolysis of phosphatidylcholine, in the induction of protein kinase C activity and the events leading to cell proliferation in response to IL-3. Phosphatidylcholines 74-93 interleukin 3 Mus musculus 201-205 1839615-2 1991 The phospholipid-binding properties of CPB-II were investigated by measuring the binding constants of [125I]-CPB-II using phospholipid vesicles consisting of 80% phosphatidylcholine and 20% phosphatidylserine. Phosphatidylcholines 162-181 annexin A6 Homo sapiens 39-45 1910818-7 1991 We conclude that EGF may contribute significantly to the normal onset of lung maturation by elaborating a fibroblast-derived factor that stimulates phosphatidylcholine synthesis in type II pneumocytes. Phosphatidylcholines 148-167 epidermal growth factor like 1 Rattus norvegicus 17-20 1717480-2 1991 Egg phosphatidylcholine (PC) bilayers were reconstituted with two anchorage isoforms of the adhesion molecule lymphocyte function-associated antigen 3 (LFA-3). Phosphatidylcholines 25-27 CD58 molecule Homo sapiens 152-157 1894612-4 1991 2) With [3H]cholesterol/phosphatidylcholine liposomes, the cholesterol binding parameters for L-FABP were Kd = 1.53 +/- 0.28 microM and stoichiometry 0.83 +/- 0.07 mol/mol. Phosphatidylcholines 24-43 fatty acid binding protein 1 Rattus norvegicus 94-100 1656217-0 1991 v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Phosphatidylcholines 88-107 Rous sarcoma oncogene Mus musculus 2-5 1656217-2 1991 v-Src-induced increases in radiolabeled DAG were most readily detected when phospholipids were prelabeled with myristic acid, which is incorporated predominantly into phosphatidylcholine. Phosphatidylcholines 167-186 Rous sarcoma oncogene Mus musculus 2-5 1765979-6 1991 Among the patients there was one with a variant of PAPS with hemolytic anemia and an IgM antibody to phosphatidylcholine that is akin to the natural autoantibody of normal mice encoded by germline genes VH11 and VH12. Phosphatidylcholines 101-120 immunoglobulin heavy chain (V12 family) Mus musculus 212-216 1653227-1 1991 Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5. Phosphatidylcholines 28-47 colony stimulating factor 1 (macrophage) Mus musculus 130-157 1892885-9 1991 Measurement of the activity of phospholipase A with endogenously [3H]choline-labeled PC showed that the formation of lysoPC in mitochondria isolated form choline-supplemented cells was 40% lower than in choline-deficient cells. Phosphatidylcholines 85-87 phospholipase A and acyltransferase 1 Rattus norvegicus 31-46 1892886-6 1991 Supplementation of choline-deficient rat hepatocytes, prelabeled with [3H]choline, with dimethylethanolamine increased the catabolism of PC by 1.6-fold after 6 h. This effect was accompanied by a 2.5-fold increase in the production of [3H]glycerophosphocholine (GPC). Phosphatidylcholines 137-139 glycophorin C Rattus norvegicus 262-265 1653227-1 1991 Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5. Phosphatidylcholines 49-55 colony stimulating factor 1 (macrophage) Mus musculus 130-157 1653227-1 1991 Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5. Phosphatidylcholines 49-55 colony stimulating factor 1 (macrophage) Mus musculus 159-164 1653227-4 1991 Metabolic labeling experiments pointed to CTP:phosphocholine cytidylyltransferase (CT) as the rate-controlling enzyme for PtdCho biosynthesis in BAC1.2F5 cells. Phosphatidylcholines 122-128 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 42-81 1660725-2 1991 The conversion of membrane from AChE to soluble AChE by PI-PLC depended on the presence of a detergent and of phosphatidylcholine. Phosphatidylcholines 110-129 acetylcholinesterase Bos taurus 32-36 1654115-4 1991 These results show that phospholipase A2 was activated in hypoxic myocytes and had substrate specificity towards PC and PE. Phosphatidylcholines 113-115 phospholipase A2 group IB Homo sapiens 24-40 1665301-0 1991 Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D. Phosphatidylcholines 96-115 colony stimulating factor 2 Homo sapiens 0-48 1665301-0 1991 Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D. Phosphatidylcholines 96-115 colony stimulating factor 2 Homo sapiens 50-56 1665301-0 1991 Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D. Phosphatidylcholines 96-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 129-144 1665301-2 1991 To further define the mechanism by which GM-CSF up-regulates PLD activity, we investigated the effect of GM-CSF pretreatment of neutrophils on phosphatidylcholine breakdown in response to a receptor-coupled stimulus N-formyl-methionyl-leucyl-phenylalanine (fMLP) and to a receptor-independent stimulus phorbol-myristate-acetate (PMA). Phosphatidylcholines 143-162 colony stimulating factor 2 Homo sapiens 105-111 1665301-4 1991 The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor. Phosphatidylcholines 38-57 colony stimulating factor 2 Homo sapiens 18-24 1665301-4 1991 The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor. Phosphatidylcholines 38-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 1665301-4 1991 The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor. Phosphatidylcholines 38-57 formyl peptide receptor 1 Homo sapiens 164-177 1793570-4 1991 These cells were shown to possess phosphatidylcholine-dependent BDH activity. Phosphatidylcholines 34-53 3-hydroxybutyrate dehydrogenase 1 Rattus norvegicus 64-67 1653607-6 1991 Mixed vesicles of PIP2 with phosphatidylcholine or phosphatidylethanolamine also inhibit CapZ, but addition of Triton X-100 both prevents and reverses PIP2"s inhibition of CapZ. Phosphatidylcholines 28-47 capping actin protein of muscle Z-line alpha subunit 2 Gallus gallus 89-93 1660725-2 1991 The conversion of membrane from AChE to soluble AChE by PI-PLC depended on the presence of a detergent and of phosphatidylcholine. Phosphatidylcholines 110-129 acetylcholinesterase Bos taurus 48-52 1660725-3 1991 In presence of mixed micelles containing Triton X-100 (0.05%) and phosphatidylcholine (0.5 mg/ml) the rate of AChE conversion was about 3 times higher than in presence of Triton X-100 alone. Phosphatidylcholines 66-85 acetylcholinesterase Bos taurus 110-114 1892881-3 1991 This enhancement of the cytosolic 15-lipoxygenase activity, which was reversible by EGTA, was inhibited by phosphatidyl serine and phosphatidyl choline. Phosphatidylcholines 131-151 arachidonate 15-lipoxygenase Homo sapiens 34-49 1652765-8 1991 The rate of incorporation of 14C from [14C]choline into GPC, the steady-state GPC synthesis rate, and the activity of phospholipase A2 (which can catalyze a step in the synthesis of GPC from phosphatidylcholine) are not increased by high NaCl and urea. Phosphatidylcholines 191-210 phospholipase A2 group IB Canis lupus familiaris 118-134 1788877-0 1991 [Anabolic action of prolactin on phosphatidylcholine metabolism in guinea pig adrenocorticocytes]. Phosphatidylcholines 33-52 prolactin Cavia porcellus 20-29 1788877-1 1991 Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control. Phosphatidylcholines 125-144 prolactin Cavia porcellus 64-73 1788877-1 1991 Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control. Phosphatidylcholines 125-144 prolactin Cavia porcellus 75-78 1788877-3 1991 The rate of disappearance of labelled phosphatidylcholine in adrenocortical cells prelabelled with [3H] choline was lower in cells obtained from PRL-treated animals. Phosphatidylcholines 38-57 prolactin Cavia porcellus 145-148 1788877-6 1991 The obtained data showed that prolonged influence of PRL caused a shift of the phosphatidylcholine metabolism to anabolism. Phosphatidylcholines 79-98 prolactin Cavia porcellus 53-56 1878372-9 1991 Freshly prepared Glut 1 retained high activity after separation from membrane lipids on a TSKgel G3000SW column in the presence of 40 mM octyl glucoside and 1 mM PS or PC. Phosphatidylcholines 168-170 solute carrier family 2 member 1 Homo sapiens 17-23 1878372-11 1991 The presence of a phospholipid was thus essential for retention of high activity of the Glut 1 in octyl glucoside and PC was nearly as effective as PS. Phosphatidylcholines 118-120 solute carrier family 2 member 1 Homo sapiens 88-94 1908796-2 1991 This activity is mainly distributed in the microsomal fraction (76.5% of total) and has properties similar to the mammalian PAF-acetylhydrolase since it is Ca(2+)-independent, acid-labile, is inhibited by DFP and PMSF but it is not affected by egg yolk phosphatidylcholine. Phosphatidylcholines 253-272 phospholipase A2 group VII Homo sapiens 124-143 1906891-6 1991 The rIL-1-stimulated PLA2 had an alkaline pH optimum, and phosphatidylethanolamine was preferred over phosphatidylcholine as substrate. Phosphatidylcholines 102-121 phospholipase A2 group IIA Homo sapiens 21-25 1872854-1 1991 An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 alpha-receptor expression. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 77-93 1770308-0 1991 Characterization of the discoidal complexes formed between apoA-I-CNBr fragments and phosphatidylcholine. Phosphatidylcholines 85-104 apolipoprotein A1 Homo sapiens 59-65 2061317-0 1991 Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+. Phosphatidylcholines 58-77 cut like homeobox 1 Homo sapiens 35-38 1854730-6 1991 The initial decrease in Tm (delta H or delta S) with increasing values of delta C/CL is attributed to the progressive increase in the magnitude of the chain-terminal perturbations on the conformational statistics of the adjacent hydrocarbon chains and hence the lateral chain-chain interactions of these mixed-chain phosphatidylcholines in the gel-state bilayer. Phosphatidylcholines 316-336 crystallin gamma C Homo sapiens 80-84 1854740-4 1991 The action of PLA2 on phosphatidylcholine (PC) vesicles containing a small amount of anionic phospholipid, such as phosphatidic acid (PA), was studied. Phosphatidylcholines 22-41 phospholipase A2, major isoenzyme Sus scrofa 14-18 1854740-4 1991 The action of PLA2 on phosphatidylcholine (PC) vesicles containing a small amount of anionic phospholipid, such as phosphatidic acid (PA), was studied. Phosphatidylcholines 43-45 phospholipase A2, major isoenzyme Sus scrofa 14-18 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 237-248 cut like homeobox 1 Homo sapiens 92-95 1770112-1 1991 A simple procedure is described for the purification of phosphatidylcholine-hydrolyzing phospholipase C(PLC). Phosphatidylcholines 56-75 heparan sulfate proteoglycan 2 Homo sapiens 104-107 1854804-1 1991 The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 168-171 1854804-1 1991 The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho. Phosphatidylcholines 40-46 cut like homeobox 1 Homo sapiens 168-171 2061317-11 1991 These results suggest that channeling of intermediates in the CDP-choline pathway of Ptd-choline biosynthesis in glioma cells is mediated by intracellular Ca2+ levels that may coordinately regulate the steps involved in conversion of choline to Ptd-choline. Phosphatidylcholines 85-96 cut like homeobox 1 Homo sapiens 62-65 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 92-95 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 219-222 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 40-51 cut like homeobox 1 Homo sapiens 92-95 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 40-51 cut like homeobox 1 Homo sapiens 219-222 1654818-1 1991 Cytochrome c(3+)-catalyzed peroxidation of phosphatidylcholine liposomes by hydrogen peroxide (H2O2) was indicated by the production of thiobarbituric acid reactive substances, oxygen consumption, and emission of spontaneous chemiluminescence. Phosphatidylcholines 43-62 cytochrome c, somatic Homo sapiens 0-12 2059651-1 1991 We investigate various models of the hydrolysis of gel-phase phosphatidylcholine monolayers by phospholipase A2 (Grainger et al. Phosphatidylcholines 61-80 phospholipase A2 group IB Homo sapiens 95-111 1920900-0 1991 [The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini]. Phosphatidylcholines 45-64 cholecystokinin Rattus norvegicus 26-41 1920900-3 1991 Pulse-chase study revealed that CCK reduced both the disappearance of phosphocholine and the synthesis of PC. Phosphatidylcholines 106-108 cholecystokinin Rattus norvegicus 32-35 1920900-6 1991 These results suggest that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP: phosphocholine cytidylyltransferase activity. Phosphatidylcholines 40-42 cholecystokinin Rattus norvegicus 27-30 1920900-6 1991 These results suggest that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP: phosphocholine cytidylyltransferase activity. Phosphatidylcholines 40-42 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 135-175 2059654-6 1991 The data demonstrate that, in MDCK cells: (a) PC-TP can modify the PC species present in the plasma membrane; (b) PC accounts for a significant amount of the polar lipids present in the external leaflet of the apical membrane domain. Phosphatidylcholines 67-69 phosphatidylcholine transfer protein Canis lupus familiaris 46-51 1934174-1 1991 The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied. Phosphatidylcholines 69-88 interferon gamma Homo sapiens 37-53 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 0-19 kininogen 1 Homo sapiens 90-100 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 0-19 kininogen 1 Homo sapiens 102-104 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 181-200 kininogen 1 Homo sapiens 90-100 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 181-200 kininogen 1 Homo sapiens 102-104 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 202-204 kininogen 1 Homo sapiens 90-100 2037586-2 1991 Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L. Phosphatidylcholines 202-204 kininogen 1 Homo sapiens 102-104 2037586-6 1991 Stimulation with BK resulted in the rapid and synchronous formation of [3H]choline and [3H]myristoyl-PA from the correspondingly prelabeled PC, indicative of phospholipase D (PLD) activity. Phosphatidylcholines 140-142 kininogen 1 Homo sapiens 17-19 2037586-6 1991 Stimulation with BK resulted in the rapid and synchronous formation of [3H]choline and [3H]myristoyl-PA from the correspondingly prelabeled PC, indicative of phospholipase D (PLD) activity. Phosphatidylcholines 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-173 2040620-6 1991 To identify potential substrates, we synthesized phosphatidylcholines with sn-2 residues from two to nine carbon atoms long, and found the V/k ratio decreased as the sn-2 residue was lengthened: the C5 homolog was 50%, the C6 20%, while the C9 homolog was only 2% as efficient as PAF. Phosphatidylcholines 49-69 PCNA clamp associated factor Homo sapiens 280-283 2037585-1 1991 I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA). Phosphatidylcholines 70-89 kininogen 1 Homo sapiens 161-171 2037585-1 1991 I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA). Phosphatidylcholines 70-89 kininogen 1 Homo sapiens 173-175 1934174-1 1991 The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied. Phosphatidylcholines 69-88 interferon gamma Homo sapiens 55-58 1828227-6 1991 A dose-dependent inhibition of phospholipase A2 by both annexins VI and IV, at millimolar concentrations of Ca2+ was observed when phosphatidylcholine liposomes were used as a substrate. Phosphatidylcholines 131-150 phospholipase A2 group IB Homo sapiens 31-47 1646299-8 1991 Phosphatidylcholine-mediated delivery of anti-GAP-43 antibodies (alpha GAP) into cells immediately before dbcAMP treatment arrested neuritogenesis but did not induce the retraction of existing neurites. Phosphatidylcholines 0-19 growth associated protein 43 Mus musculus 46-52 1903207-6 1991 Phosphatidylcholine (PC) and phosphatidylinositol turnover were increased by insulin (P less than 0.025 and less than 0.05, respectively). Phosphatidylcholines 0-19 insulin Homo sapiens 77-84 1903207-6 1991 Phosphatidylcholine (PC) and phosphatidylinositol turnover were increased by insulin (P less than 0.025 and less than 0.05, respectively). Phosphatidylcholines 21-23 insulin Homo sapiens 77-84 1903207-10 1991 We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC. Phosphatidylcholines 131-133 insulin Homo sapiens 17-24 1903207-10 1991 We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC. Phosphatidylcholines 244-246 insulin Homo sapiens 17-24 2036455-0 1991 Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E. Phosphatidylcholines 39-58 lipase C, hepatic type Homo sapiens 14-28 1654804-0 1991 Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells. Phosphatidylcholines 26-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-70 1903932-0 1991 Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Phosphatidylcholines 23-42 angiotensinogen Homo sapiens 0-14 1828037-1 1991 Mouse NIH 3T3 fibroblasts transfected with human colony stimulating factor-1 receptor produced diacylglycerol in response to CSF1 and this correlated with elevated phosphatidylcholine hydrolyzing activity measured in an in vitro assay. Phosphatidylcholines 164-183 colony stimulating factor 1 receptor Homo sapiens 49-85 1828037-1 1991 Mouse NIH 3T3 fibroblasts transfected with human colony stimulating factor-1 receptor produced diacylglycerol in response to CSF1 and this correlated with elevated phosphatidylcholine hydrolyzing activity measured in an in vitro assay. Phosphatidylcholines 164-183 colony stimulating factor 1 Homo sapiens 125-129 2022654-5 1991 In the presence of phosphatidylcholine/phosphatidylserine vesicles and factor Va, two of the antibodies, alpha HII-3 and alpha HII-4, inhibited prothrombin activation at a 90 and 50% level, respectively. Phosphatidylcholines 19-38 coagulation factor II, thrombin Homo sapiens 144-155 2036455-0 1991 Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E. Phosphatidylcholines 39-58 apolipoprotein E Homo sapiens 73-89 2036455-1 1991 The effect of apolipoproteins A-I, A-II, C-II, C-III and E on the hydrolysis of phosphatidylcholine and triacylglycerol by hepatic lipase was studied. Phosphatidylcholines 80-99 NLR family pyrin domain containing 3 Homo sapiens 14-39 2036455-1 1991 The effect of apolipoproteins A-I, A-II, C-II, C-III and E on the hydrolysis of phosphatidylcholine and triacylglycerol by hepatic lipase was studied. Phosphatidylcholines 80-99 lipase C, hepatic type Homo sapiens 123-137 2022747-3 1991 Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE. Phosphatidylcholines 112-131 phospholipase A2 group IB Rattus norvegicus 13-17 1910734-11 1991 Addition of bovine serum albumin (fatty acid free) to assays increased the rate of release of arachidonate from phosphatidylcholine, but not from phosphatidylethanolamine. Phosphatidylcholines 112-131 albumin Homo sapiens 19-32 2022747-3 1991 Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE. Phosphatidylcholines 133-135 phospholipase A2 group IB Rattus norvegicus 13-17 1663404-3 1991 ESR measurements of 5-doxyl stearic acid, as a spin probe, show that PAF disorients phosphatidylcholine bilayers when present at molar ratios greater than 40%. Phosphatidylcholines 84-103 PCNA clamp associated factor Homo sapiens 69-72 2016306-6 1991 The main step in the catabolism of 1-acyl-2-acetyl-GPC is the removal of the long chain at the sn-1 position; the long chain residue is subsequently incorporated either into triglycerides or into phosphatidylcholine. Phosphatidylcholines 196-215 glycophorin C (Gerbich blood group) Homo sapiens 51-54 2026154-1 1991 We have compared the action of lipoprotein lipase on liposomes of egg yolk phosphatidylcholine containing less than saturating amounts of trioleoylglycerol (less than 3%) and emulsion droplets of the same lipids. Phosphatidylcholines 75-94 lipoprotein lipase Homo sapiens 31-49 1902664-5 1991 Thrombin stimulated the decrease in PtdIns and phosphatidylcholine contents. Phosphatidylcholines 47-66 coagulation factor II, thrombin Homo sapiens 0-8 2016297-0 1991 Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. Phosphatidylcholines 55-74 insulin S homeolog Xenopus laevis 131-138 2016297-0 1991 Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. Phosphatidylcholines 55-74 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 147-150 1708286-8 1991 CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine. Phosphatidylcholines 67-86 cholecystokinin Rattus norvegicus 0-3 1708286-8 1991 CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine. Phosphatidylcholines 67-86 phospholipase A and acyltransferase 1 Rattus norvegicus 25-40 1708286-8 1991 CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine. Phosphatidylcholines 67-86 phospholipase A and acyltransferase 1 Rattus norvegicus 42-45 1708286-10 1991 The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation. Phosphatidylcholines 174-193 cholecystokinin Rattus norvegicus 51-54 1708286-10 1991 The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation. Phosphatidylcholines 174-193 phospholipase A and acyltransferase 1 Rattus norvegicus 148-151 2016297-1 1991 Recent studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine both by growth factors and by the product of ras oncogene, ras p21. Phosphatidylcholines 90-109 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 173-176 1910288-3 1991 Tumor-derived cells exhibited significant PLA2 activity(ies) with arachidonoyl containing phosphatidylcholine and phosphatidylethanolamine as substrates in cell-free assays. Phosphatidylcholines 90-109 phospholipase A2, group IB, pancreas Mus musculus 42-46 2012808-7 1991 The insertion at amino acid 379 occurs immediately after a triplet of lysine residues, suggesting that this region might be involved in an essential step in the mechanism of CE and TG transfer, such as the binding of CETP to phosphatidylcholine molecules in the lipoprotein surface. Phosphatidylcholines 225-244 cholesteryl ester transfer protein Homo sapiens 217-221 2018133-3 1991 Differences in the distribution of phosphatidylcholine and phosphatidylethanolamine, as assessed by phospholipase A2 treatment and trinitrophenylation of aminophospholipids, were, at least partially, responsible for the asymmetrical fluidity of the hemileaflets. Phosphatidylcholines 35-54 phospholipase A2 group IB Rattus norvegicus 100-116 2007582-3 1991 In the absence of added Ca2+ adriamycin caused a 3-4-fold activation of hydrolysis of this pyrenelipid whereas an inhibition of action of PLA2 on the corresponding phosphatidylcholine derivative C28-O-PHPC was observed. Phosphatidylcholines 164-183 phospholipase A2 group IB Homo sapiens 138-142 1910288-6 1991 The pH profiles for hydrolysis of phosphatidylcholine and phosphatidylethanolamine differed; all other aspects of PLA2-mediated hydrolysis of these two substrates were similar including a Ca2+ requirement for activity. Phosphatidylcholines 34-53 phospholipase A2, group IB, pancreas Mus musculus 114-118 1829383-0 1991 Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG). Phosphatidylcholines 47-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-101 1829383-0 1991 Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG). Phosphatidylcholines 47-66 phospholipase D1 Homo sapiens 147-170 1829383-0 1991 Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG). Phosphatidylcholines 231-250 phospholipase D1 Homo sapiens 147-170 1829383-0 1991 Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG). Phosphatidylcholines 252-254 phospholipase D1 Homo sapiens 147-170 2019995-5 1991 Treatment of cells with A-4, A-5 and HC-3 resulted in an increase in the incorporation of S-adenosyl-methionine into phosphatidylcholine. Phosphatidylcholines 117-136 ATPase, H+ transporting, lysosomal V0 subunit A4 Mus musculus 24-27 2059659-6 1991 Furthermore, sustained increases in 1,2-diacylglycerol in response to alpha-thrombin are regulated at least in part at the level of generation (via phosphatidylcholine hydrolysis). Phosphatidylcholines 148-167 coagulation factor II, thrombin Homo sapiens 76-84 2019995-5 1991 Treatment of cells with A-4, A-5 and HC-3 resulted in an increase in the incorporation of S-adenosyl-methionine into phosphatidylcholine. Phosphatidylcholines 117-136 laminin, alpha 5 Mus musculus 29-32 2019995-7 1991 Phosphatidylcholine turnover was decreased in cells treated with A-4 and A-5. Phosphatidylcholines 0-19 ATPase, H+ transporting, lysosomal V0 subunit A4 Mus musculus 65-68 2019995-7 1991 Phosphatidylcholine turnover was decreased in cells treated with A-4 and A-5. Phosphatidylcholines 0-19 laminin, alpha 5 Mus musculus 73-76 2019995-8 1991 A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway. Phosphatidylcholines 156-175 ATPase, H+ transporting, lysosomal V0 subunit A4 Mus musculus 0-3 2019995-8 1991 A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway. Phosphatidylcholines 156-175 laminin, alpha 5 Mus musculus 5-8 2019995-8 1991 A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway. Phosphatidylcholines 191-210 ATPase, H+ transporting, lysosomal V0 subunit A4 Mus musculus 0-3 2019995-8 1991 A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway. Phosphatidylcholines 191-210 laminin, alpha 5 Mus musculus 5-8 1999422-11 1991 Therefore, the lipid-containing vesicles derived from endoplasmic reticulum must have combined with cis Golgi apparatus membranes as the basis for Golgi apparatus-dependent phospholipase A processing of endoplasmic reticulum-derived phosphatidylcholine. Phosphatidylcholines 233-252 phospholipase A and acyltransferase 1 Rattus norvegicus 173-188 1826088-2 1991 In this study, experiments are presented that utilize a pyrene derivative of phosphatidylcholine to examine the Ca2(+)-dependent membrane binding of soluble human annexin V and other annexins. Phosphatidylcholines 77-96 annexin A5 Homo sapiens 163-172 2002032-10 1991 At a high surface pressure of 25 mN/m all apolipoproteins tested (apolipoproteins A-I, A-II, C-I, C-II, C-III, and E) inhibited the penetration into and HL activity on phosphatidylethanolamine At 18.5 mN/m all apolipoproteins except apolipoprotein E inhibited the hydrolysis of triacylglycerol in the triacylglycerol:phosphatidylcholine mixed film. Phosphatidylcholines 317-336 NLR family pyrin domain containing 3 Homo sapiens 42-96 2027529-1 1991 Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells. Phosphatidylcholines 252-271 endothelin 1 Rattus norvegicus 29-41 1907204-7 1991 Together with the observation that PC was found to decrease upon BK stimulation, these observations suggest that the late phase of DAG accumulation may involve breakdown of other phospholipids including PC. Phosphatidylcholines 35-37 kininogen 1 Homo sapiens 65-67 2027529-1 1991 Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells. Phosphatidylcholines 252-271 endothelin 1 Rattus norvegicus 43-45 1997207-1 1991 SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. Phosphatidylcholines 46-65 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-6 1997207-4 1991 The antagonistic action of the CKI gene product on SEC14p function revealed a previously unsuspected influence of biosynthetic activities of the CDP-choline pathway for PC biosynthesis on yeast Golgi function and indicated that SEC14p controls the phospholipid content of yeast Golgi membranes in vivo. Phosphatidylcholines 169-171 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 51-57 2027529-1 1991 Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells. Phosphatidylcholines 273-275 endothelin 1 Rattus norvegicus 29-41 2027529-1 1991 Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells. Phosphatidylcholines 273-275 endothelin 1 Rattus norvegicus 43-45 2027529-4 1991 In addition to other possible roles, ET may also mediate mitogenesis in the brain, presumably through a PKC-dependent activation of phospholipase C and/or D hydrolyzing PC. Phosphatidylcholines 169-171 endothelin 1 Rattus norvegicus 37-39 1993681-8 1991 In the complex of lipids and apoA-I or apoA-II, the weight ratios of apolipoprotein/cholesterol/phosphatidylcholine/sphingomyelin/lysophosphatidyl- choline were estimated as 2.2:1:0.6:0.2:0.07 and 4.0:1:0.5:0.3:0.07, respectively. Phosphatidylcholines 96-115 apolipoprotein A1 Homo sapiens 29-35 1993681-8 1991 In the complex of lipids and apoA-I or apoA-II, the weight ratios of apolipoprotein/cholesterol/phosphatidylcholine/sphingomyelin/lysophosphatidyl- choline were estimated as 2.2:1:0.6:0.2:0.07 and 4.0:1:0.5:0.3:0.07, respectively. Phosphatidylcholines 96-115 apolipoprotein A2 Homo sapiens 39-46 1993695-1 1991 Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts. Phosphatidylcholines 40-59 coagulation factor II, thrombin Homo sapiens 90-98 1985909-2 1991 PKC association to a mixed phospholipid film (phosphatidylcholine, phosphatidylserine) could be detected by an increase of the monolayer surface pressure. Phosphatidylcholines 46-65 proline rich transmembrane protein 2 Homo sapiens 0-3 1900197-1 1991 C-reactive protein was highly purified from Japanese eel (Anguilla japonica) serum by precipitation with phosphatidyl-choline and Ca2+. Phosphatidylcholines 105-125 C-reactive protein Homo sapiens 0-18 1899026-1 1991 Chromaffin granule membranes prepared from bovine adrenal medullae showed Ca2(+)-stimulated phospholipase A2 (PLA2) activity when assayed at pH 9.0 with phosphatidylcholine containing an [14C]-arachidonyl group in the 2-position. Phosphatidylcholines 153-172 LOC104974671 Bos taurus 92-108 1899026-1 1991 Chromaffin granule membranes prepared from bovine adrenal medullae showed Ca2(+)-stimulated phospholipase A2 (PLA2) activity when assayed at pH 9.0 with phosphatidylcholine containing an [14C]-arachidonyl group in the 2-position. Phosphatidylcholines 153-172 LOC104974671 Bos taurus 110-114 1898904-8 1991 Phosphorylcholine, a product of phospholipase C activity on the major lung surfactant phosphatidylcholine, was also used as a growth substrate in nutrient limitation studies. Phosphatidylcholines 86-105 phospholipase C Pseudomonas aeruginosa PAO1 32-47 1999479-8 1991 In cells labelled with [3H]choline, the water soluble phosphatidylcholine hydrolysis products, phosphorylcholine and choline, were increased 2-fold within 5 minutes of addition of EGF. Phosphatidylcholines 54-73 epidermal growth factor Homo sapiens 180-183 1999479-16 1991 Thus, the induction of 1,2-diacylglycerol by EGF may occur primarily via phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 113-132 epidermal growth factor Homo sapiens 45-48 2038071-8 1991 In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 204-223 phospholipase A2 group IB Homo sapiens 156-172 2038071-8 1991 In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 204-223 phospholipase A2 group IB Homo sapiens 174-178 2038071-8 1991 In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 89-91 phospholipase A2 group IB Homo sapiens 156-172 2038071-8 1991 In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 89-91 phospholipase A2 group IB Homo sapiens 174-178 2051995-3 1991 Direct evidence came when liposomes made of egg yolk phosphatidylcholine, containing both [14C]labeled phospholipids and [1-14C] palmitic acid were incubated with FABP. Phosphatidylcholines 53-72 glutamatic-oxaloacetic transaminase 2, mitochondrial Mus musculus 163-167 1776744-2 1991 Experimental studies have shown that the administration of CDP-choline increases the total amount of phosphatidylcholine and other related phospholipids in the brain and in some cases may enhance neurotransmission. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 59-62 1991158-8 1991 These results suggest that an eicosanoid-independent degradation of phosphatidylethanolamine via phospholipase A2 at lower collagen levels may provide a source of the initial AA for conversion to TxA2 and the subsequent deacylation of phosphatidylinositol, phosphatidylcholine, and also phosphatidylserine. Phosphatidylcholines 257-276 phospholipase A2 group IB Homo sapiens 97-113 1859438-3 1991 Comparative studies on the effects of pH, salt, and temperature on the phosphatidylcholine transfer activity revealed that PC-TP from porcine and bovine livers were similar as far as its activity is concerned. Phosphatidylcholines 71-90 phosphatidylcholine transfer protein Bos taurus 123-128 1723301-1 1991 Carbonic anhydrase (CA) from mouse erythrocyte membranes is recognised as an autoantigen in Western blotting experiments with FUB 1, a murine IgM monoclonal antibody that binds both phosphatidylcholine and bromelain-treated mouse red blood cells (BrMRBC). Phosphatidylcholines 182-201 FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens 126-131 1854590-2 1991 Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. Phosphatidylcholines 84-103 interleukin 2 Rattus norvegicus 18-31 1648354-0 1991 [Recombination of micellar complexes of apolipoprotein A1--phosphatidylcholine in the presence of complex components]. Phosphatidylcholines 59-78 apolipoprotein A1 Homo sapiens 40-57 1648355-7 1991 These data show the importance of hydrophobic protein-protein interactions for the structure of HDL and synthetic complexes of apoA1 with phosphatidyl choline. Phosphatidylcholines 138-158 apolipoprotein A1 Homo sapiens 127-132 1854590-2 1991 Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. Phosphatidylcholines 84-103 interleukin 2 Rattus norvegicus 33-37 1854590-2 1991 Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. Phosphatidylcholines 105-107 interleukin 2 Rattus norvegicus 18-31 1854590-2 1991 Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. Phosphatidylcholines 105-107 interleukin 2 Rattus norvegicus 33-37 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. Phosphatidylcholines 26-45 procollagen C-endopeptidase enhancer Rattus norvegicus 47-49 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 73-92 C-reactive protein Homo sapiens 19-22 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 66-68 C-reactive protein Homo sapiens 19-22 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 94-96 C-reactive protein Homo sapiens 19-22 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. Phosphatidylcholines 26-45 procollagen C-endopeptidase enhancer Rattus norvegicus 106-111 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. Phosphatidylcholines 26-45 procollagen C-endopeptidase enhancer Rattus norvegicus 195-200 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 160-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 1875789-4 1991 In addition, pretreatment of culture with the combination of superoxide dismutase and catalase inhibited the increase in PC secretion. Phosphatidylcholines 121-123 catalase Rattus norvegicus 86-94 27463477-9 1991 From 5-20% of normal adult CD5 B cells (and lymphomas) produce antibody reactive with phosphatidyl choline. Phosphatidylcholines 86-106 CD5 antigen Mus musculus 27-30 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 160-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 181-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 2028524-1 1991 Methemoglobin effect on the structure of phosphatidylcholine liposomes was studied using sulfophthalein dye bromthymol blue. Phosphatidylcholines 41-60 hemoglobin subunit gamma 2 Homo sapiens 0-13 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 181-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 2027252-2 1991 PLA2 activity was measured by radiochemical method using phosphatidylcholine as a substrate. Phosphatidylcholines 57-76 phospholipase A2 group IB Homo sapiens 0-4 2125219-0 1990 Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown. Phosphatidylcholines 88-107 growth hormone Mus musculus 37-51 2125219-6 1990 It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein. Phosphatidylcholines 99-118 growth hormone Mus musculus 21-35 19431774-1 1990 PYRENE FLUORESCENCE QUENCHING BY PLASTOQUINONE WAS USED TO ESTIMATE THE RATE OF PLASTOQUINONE LATERAL DIFFUSION IN SOYBEAN PHOSPHATIDYLCHOLINE PROTEOLIPOSOMES CONTAINING THE FOLLOWING INTEGRAL MEMBRANE PROTEINS: gramicidin D, spinach cytochrome bf complex, spinach cytochrome f, reaction centers from Rhodobacter sphaeroides, beef heart mitochondrial cytochrome bc(1), and beef heart mitochondrial cytochrome oxidase. Phosphatidylcholines 123-142 apocytochrome f precursor Spinacia oleracea 265-277 2257300-4 1990 In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition. Phosphatidylcholines 170-189 tissue factor pathway inhibitor Homo sapiens 41-45 2257300-4 1990 In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition. Phosphatidylcholines 170-189 coagulation factor III, tissue factor Homo sapiens 70-83 2129343-5 1990 Incubation of PT cells with D-alpha-dipalmitoyl phosphatidylcholine (0-200 micrograms/ml medium) also stimulated the activity of GalT-2, maximum stimulation (200%) occurring with 25 micrograms phosphatidylcholine/ml medium. Phosphatidylcholines 48-67 beta-1,3-galactosyltransferase 4 Homo sapiens 129-135 2246516-6 1990 When exogenous [3H]PAF was added to the two stimulated eosinophil populations subsequent analysis of the [3H]PAF metabolites by DIOL-HPLC revealed that low density eosinophils incorporated PAF into the phosphatidylcholine (PC) pool more rapidly than did normal density eosinophils or neutrophils. Phosphatidylcholines 202-221 PCNA clamp associated factor Homo sapiens 19-22 2246516-6 1990 When exogenous [3H]PAF was added to the two stimulated eosinophil populations subsequent analysis of the [3H]PAF metabolites by DIOL-HPLC revealed that low density eosinophils incorporated PAF into the phosphatidylcholine (PC) pool more rapidly than did normal density eosinophils or neutrophils. Phosphatidylcholines 223-225 PCNA clamp associated factor Homo sapiens 19-22 2246516-7 1990 Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway. Phosphatidylcholines 27-29 PCNA clamp associated factor Homo sapiens 179-182 2246516-7 1990 Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway. Phosphatidylcholines 27-29 PCNA clamp associated factor Homo sapiens 195-198 2246516-7 1990 Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway. Phosphatidylcholines 128-130 PCNA clamp associated factor Homo sapiens 179-182 2246516-7 1990 Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway. Phosphatidylcholines 128-130 PCNA clamp associated factor Homo sapiens 195-198 2257300-4 1990 In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition. Phosphatidylcholines 105-124 tissue factor pathway inhibitor Homo sapiens 41-45 2257300-4 1990 In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition. Phosphatidylcholines 105-124 coagulation factor III, tissue factor Homo sapiens 70-83 2088393-0 1990 Hemolytic anemia related to an IgM autoantibody to phosphatidylcholine that binds in vitro to stored and to bromelain-treated human erythrocytes. Phosphatidylcholines 51-70 immunoglobulin heavy constant mu Mus musculus 31-34 2088393-1 1990 Both normal and autoimmune mice have IgM natural autoantibodies to bromelain-treated erythrocytes in which phosphatidylcholine (PTC) becomes exposed. Phosphatidylcholines 107-126 immunoglobulin heavy constant mu Mus musculus 37-40 2088393-1 1990 Both normal and autoimmune mice have IgM natural autoantibodies to bromelain-treated erythrocytes in which phosphatidylcholine (PTC) becomes exposed. Phosphatidylcholines 128-131 immunoglobulin heavy constant mu Mus musculus 37-40 2093138-3 1990 This effect could be attributed to an enhancement by PGE1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e., the substrate and product of lecithin-cholesterol acyltransferase (LCAT). Phosphatidylcholines 94-113 lecithin-cholesterol acyltransferase Homo sapiens 173-209 2093138-3 1990 This effect could be attributed to an enhancement by PGE1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e., the substrate and product of lecithin-cholesterol acyltransferase (LCAT). Phosphatidylcholines 94-113 lecithin-cholesterol acyltransferase Homo sapiens 211-215 1701623-3 1990 The proportion of 18:2 in serum phosphatidylcholine correlated inversely with such acute phase proteins as orosomucoid and C reactive protein. Phosphatidylcholines 32-51 C-reactive protein Homo sapiens 123-141 2280671-0 1990 Vasopressin stimulates phospholipase D activity against phosphatidylcholine in vascular smooth muscle cells. Phosphatidylcholines 56-75 arginine vasopressin Homo sapiens 0-11 2280671-2 1990 We have investigated the production of diacylglycerol from nonphosphoinositide sources, and we demonstrated that vasopressin and other vasoactive agents stimulate hydrolysis of phosphatidylcholine in a variety of cultured vascular smooth muscle cells of rat and human origin. Phosphatidylcholines 177-196 arginine vasopressin Rattus norvegicus 113-124 2280670-2 1990 Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called sterol carrier protein), enhanced the initial rate of sterol exchange between neutral zwitterionic phosphatidylcholine small unilamellar vesicles (SUV) 2.3-fold. Phosphatidylcholines 234-253 sterol carrier protein 2 Homo sapiens 0-24 2280670-2 1990 Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called sterol carrier protein), enhanced the initial rate of sterol exchange between neutral zwitterionic phosphatidylcholine small unilamellar vesicles (SUV) 2.3-fold. Phosphatidylcholines 234-253 sterol carrier protein 2 Homo sapiens 26-30 2280671-3 1990 We used vasopressin to characterize this response and found that vasopressin stimulates phospholipase D activity against phosphatidylcholine in A-10 vascular smooth muscle cells. Phosphatidylcholines 121-140 arginine vasopressin Homo sapiens 65-76 2280671-4 1990 The vasopressin-stimulated phosphatidylcholine hydrolysis is both time- and concentration-dependent. Phosphatidylcholines 27-46 arginine vasopressin Homo sapiens 4-15 2280671-5 1990 The half-maximal dose of vasopressin required for phosphatidylcholine hydrolysis (ED50 approximately 1 nM) correlates well with vasopressin binding to A-10 cells (Kd approximately 2 nM). Phosphatidylcholines 50-69 arginine vasopressin Homo sapiens 25-36 2280671-5 1990 The half-maximal dose of vasopressin required for phosphatidylcholine hydrolysis (ED50 approximately 1 nM) correlates well with vasopressin binding to A-10 cells (Kd approximately 2 nM). Phosphatidylcholines 50-69 arginine vasopressin Homo sapiens 128-139 2280671-6 1990 The phosphatidylcholine in A-10 cells can be preferentially radiolabeled with [3H]myristic acid; subsequent treatment with vasopressin stimulates a rapid increase in 3H-labeled phosphatidate (approximately 4 X control values at 3 min), and after a short lag, 3H-labeled diacylglycerol rises and reaches maximal levels at 10 min (approximately 2 X control values). Phosphatidylcholines 4-23 arginine vasopressin Homo sapiens 123-134 2280671-11 1990 The data indicate that vasopressin stimulates phospholipase D which hydrolyzes phosphatidylcholine to phosphatidate. Phosphatidylcholines 79-98 arginine vasopressin Homo sapiens 23-34 2170380-0 1990 Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Phosphatidylcholines 45-64 arginine vasopressin Rattus norvegicus 0-11 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylcholines 78-97 arginine vasopressin Rattus norvegicus 25-27 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylcholines 99-101 arginine vasopressin Rattus norvegicus 25-27 2266956-10 1990 Equilibration of PADPH between L-FABP and phosphatidylcholine (PC) bilayers resulted in a molar partition preference of greater than 20: 1, L-FABP PC. Phosphatidylcholines 42-61 fatty acid binding protein 1 Homo sapiens 140-146 2170380-6 1990 In cells prelabeled with [3H]myristic acid, which is predominantly incorporated into cellular PC, VP elicited the generation of [3H]myristoyl phosphatidate (PA) as early as 15 s, in the absence of an increase in labeled DG. Phosphatidylcholines 94-96 arginine vasopressin Rattus norvegicus 98-100 2222467-5 1990 It is possible that SAT-1 activation involves the structurally similar hydrophobic moieties and quaternary amino groups of LDAO and phosphatidylcholine. Phosphatidylcholines 132-151 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 20-25 2266956-10 1990 Equilibration of PADPH between L-FABP and phosphatidylcholine (PC) bilayers resulted in a molar partition preference of greater than 20: 1, L-FABP PC. Phosphatidylcholines 63-65 fatty acid binding protein 1 Homo sapiens 140-146 2120207-12 1990 These results indicate that, in primed competent Balb/c 3T3 cells, IGF-I stimulates 1,2-DAG production via multiple pathways and that IGF-I may induce breakdown of phosphatidylcholine by a mechanism involving protein kinase C. Phosphatidylcholines 164-183 insulin-like growth factor 1 Mus musculus 134-139 1979609-11 1990 Pf of endosomes containing the VP-sensitive water channel decreased fourfold by increasing membrane fluidity with hexanol or chloroform (0-75 mM); Pf of phosphatidylcholine liposomes (0.002 cm/s) increased 2.5-fold under the same conditions. Phosphatidylcholines 153-172 arginine vasopressin Homo sapiens 31-33 2084499-6 1990 Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces. Phosphatidylcholines 107-126 coagulation factor X Homo sapiens 53-56 2084499-6 1990 Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces. Phosphatidylcholines 107-126 coagulation factor III, tissue factor Homo sapiens 72-74 2084499-6 1990 Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces. Phosphatidylcholines 128-130 coagulation factor X Homo sapiens 53-56 2084499-6 1990 Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces. Phosphatidylcholines 128-130 coagulation factor III, tissue factor Homo sapiens 72-74 2223864-2 1990 The hydrolysis of phosphatidylcholine in vitro catalyzed by porcine pancreatic PLA2 was inhibited by heparin. Phosphatidylcholines 18-37 phospholipase A2 group IB Homo sapiens 79-83 2223865-4 1990 Despite these observations, in view of the putative role of microsomal phospholipase A2 in remodelling phosphatidylcholines for pulmonary surfactant biosynthesis, the purification of phospholipase A2 from microsomal membranes was investigated. Phosphatidylcholines 103-123 phospholipase A2 Oryctolagus cuniculus 71-87 2171663-10 1990 The nsLTP also mediates an approximately equal rate of exchange of cholesterol and phosphatidylcholine. Phosphatidylcholines 83-102 sterol carrier protein 2 Homo sapiens 4-9 2079600-7 1990 When HDL3 was added to the culture medium, a two- to threefold increase in phosphatidylcholine synthesis and a twofold increase in sphingomyelin formation was observed after 3 h. Ca2+ antagonists of the dihydropyridine type, which down-regulate HDL-receptor activity and promote the formation and cellular release of lamellar bodies derived from the lysosomal compartment (Schmitz, G., et al. Phosphatidylcholines 75-94 high density lipoprotein (HDL) level 3 Mus musculus 5-9 2175955-0 1990 Phosphatidylcholine breakdown in HDL3 stimulated platelets. Phosphatidylcholines 0-19 HDL3 Homo sapiens 33-37 2271538-2 1990 Both the phosphatidylcholine transfer protein (PC-TP) and the phosphatidylinositol transfer protein (PI-TP) act as carriers of phosphatidylcholine (PC) molecules between membranes. Phosphatidylcholines 9-28 phosphatidylcholine transfer protein Bos taurus 47-52 2271538-2 1990 Both the phosphatidylcholine transfer protein (PC-TP) and the phosphatidylinositol transfer protein (PI-TP) act as carriers of phosphatidylcholine (PC) molecules between membranes. Phosphatidylcholines 47-49 phosphatidylcholine transfer protein Bos taurus 9-45 2175955-1 1990 Low concentrations of HDL3 stimulate a transient biphasic increase in 1,2-diacylglycerol (DAG), with an early phase peaking at 30 seconds and a late phase at 60 seconds in (3H)-phosphatidylcholine prelabelled platelets. Phosphatidylcholines 177-196 HDL3 Homo sapiens 22-26 2250200-7 1990 Films containing PC with SPA were more expanded on a subphase containing calcium compared to a subphase with no calcium. Phosphatidylcholines 17-19 surfactant protein A2 Homo sapiens 25-28 2252906-1 1990 The techniques of ultrafast freezing and freeze-etch electron microscopy have been successfully employed to visualize IgG molecules and Fab fragments specifically bound to the neutral glycosphingolipids Forssman and asialo-GM1 incorporated into phosphatidylcholine liposomes. Phosphatidylcholines 245-264 FA complementation group B Homo sapiens 136-139 2201747-9 1990 The formation of PEt associated with a concomitant decrease in PdtOH directly demonstrated that the mechanism by which GM-CSF enhances PdtOH production is activation of a PLD active on phosphatidylcholine. Phosphatidylcholines 185-204 colony stimulating factor 2 Homo sapiens 119-125 2201747-9 1990 The formation of PEt associated with a concomitant decrease in PdtOH directly demonstrated that the mechanism by which GM-CSF enhances PdtOH production is activation of a PLD active on phosphatidylcholine. Phosphatidylcholines 185-204 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 171-174 2196173-7 1990 Moreover, the results indicate that CSF-1 stimulation is associated with decreases in PC, but not in phosphatidylinositol (PI), levels. Phosphatidylcholines 86-88 colony stimulating factor 1 Homo sapiens 36-41 1697768-8 1990 The interaction between the mAbs and the hydrophobic moieties of PC molecules was further studied by analyzing the effect of the mAbs on the activities of phospholipase A2 and phospholipase C. JE-1 inhibited both enzyme activities, while JE-8 inhibited only the phospholipase C activity, indicating that JE-1 interacts more thoroughly with the hydrophobic region of the PC molecule than JE-8 does. Phosphatidylcholines 65-67 phospholipase A2 group IB Homo sapiens 155-171 2380172-1 1990 Self- or concentration quenching of octadecylrhodamine B (C18-Rh) fluorescence increases linearly in egg phosphatidylcholine (PC) vesicles but exponentially in vesicles composed of egg PC:cholesterol, 1:1, as the probe concentration is raised to 10 mol%. Phosphatidylcholines 105-124 Bardet-Biedl syndrome 9 Homo sapiens 58-61 2380172-6 1990 Decreases in the steady-state polarization of C18-Rh fluorescence as its concentration is raised to 10 mol% indicate energy transfer with emission between probe molecules in PC and to a lesser extent in PC + cholesterol membranes. Phosphatidylcholines 174-176 Bardet-Biedl syndrome 9 Homo sapiens 46-49 2386798-7 1990 Additional experiments indicated that hydroperoxides of phosphatidylcholine, cholesterol and cholesteryl esters in low-density lipoprotein are also good substrates for PHGPX. Phosphatidylcholines 56-75 glutathione peroxidase 4 Homo sapiens 168-173 2196173-9 1990 In contrast, CSF-1 stimulation was associated with increased hydrolysis of PC to phosphorylcholine and diacylglycerol (DAG) in both intact monocytes and cell-free assays. Phosphatidylcholines 75-77 colony stimulating factor 1 Homo sapiens 13-18 1699142-0 1990 An analysis of the regions of the myelin basic protein that bind to phosphatidylcholine. Phosphatidylcholines 68-87 myelin basic protein Mus musculus 34-54 2395001-3 1990 IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha. Phosphatidylcholines 26-45 interferon alpha 1 Homo sapiens 0-9 2395001-3 1990 IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha. Phosphatidylcholines 26-45 interferon alpha 1 Homo sapiens 182-191 2395001-3 1990 IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha. Phosphatidylcholines 26-45 interferon alpha 1 Homo sapiens 182-191 1699142-1 1990 The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined. Phosphatidylcholines 20-39 myelin basic protein Mus musculus 63-83 1699142-1 1990 The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined. Phosphatidylcholines 20-39 myelin basic protein Mus musculus 85-88 1699142-1 1990 The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined. Phosphatidylcholines 41-43 myelin basic protein Mus musculus 63-83 1699142-2 1990 In solid phase binding assays the nature of the binding of unilamellar vesicles of 14C-labeled phosphatidylcholine to bovine 18.5 kDa MBP, its N- and C-terminal peptide fragments, photooxidized 18.5 kDa MBP and the mouse 14 kDa protein, with an internal deletion of residues 117-157, was studied. Phosphatidylcholines 95-114 myelin basic protein Bos taurus 134-137 2166941-0 1990 Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis. Phosphatidylcholines 115-134 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 36-76 2166941-1 1990 CTP:phosphocholine cytidylyltransferase (EC 2.7.7.15) is a key regulatory enzyme in the synthesis of phosphatidylcholine in higher eukaryotes. Phosphatidylcholines 101-120 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 1699142-6 1990 The studies indicated that the sites of PC interaction with MBP are located in the N-terminal region of the protein. Phosphatidylcholines 40-42 myelin basic protein Mus musculus 60-63 2164068-8 1990 Our data indicate that phosphatidylcholine metabolism may be involved in IFN-gamma-regulated DAG accumulation. Phosphatidylcholines 23-42 interferon gamma Mus musculus 73-82 2335517-2 1990 Binding of apo-A-IV to egg phosphatidylcholine vesicles was rapid and did not cause release of encapsulated 6-carboxyfluorescein. Phosphatidylcholines 27-46 apolipoprotein A4 Homo sapiens 11-19 2386385-6 1990 There were, however, lower concentrations of phosphatidylcholine and phosphatidylcholine palmitate content in infants colonised by organisms with reported phospholipase A2 activity. Phosphatidylcholines 45-64 phospholipase A2 group IB Homo sapiens 155-171 2163209-9 1990 Although phorbol ester and bradykinin stimulated phosphatidylcholine turnover, isoproterenol did not. Phosphatidylcholines 49-68 kininogen 1 Homo sapiens 27-37 2126577-1 1990 The phosphatidylethanolamine (PE) N-methyltransferase (MT) system is known to convert PE to phosphatidylcholine by three successive N-methylations. Phosphatidylcholines 92-111 phosphatidylethanolamine N-methyltransferase Mus musculus 4-53 2344437-1 1990 Diacylglycerol was generated in phosphatidylcholine vesicles by incubation with Clostridium welchii phospholipase C. Newly formed diacylglycerol was rapidly converted to monoacylglycerol and glycerol when rat liver cytosol fraction was present in the incubation mixture, suggesting the presence of di- and monoacylglycerol lipase activities in this subcellular fraction. Phosphatidylcholines 32-51 monoglyceride lipase Rattus norvegicus 306-329 2344437-2 1990 On the other hand, 3H-labeled diacylglycerol co-emulsified with non-radioactive phosphatidylcholine was found to be a poor substrate for the diacylglycerol lipase. Phosphatidylcholines 80-99 lipase G, endothelial type Rattus norvegicus 156-162 2335511-6 1990 Using measurements of radiolabeled headgroup release and molecular species analysis, we previously determined that alpha-thrombin generates diglycerides through the hydrolysis of both the phosphoinositides and phosphatidylcholine at early times (15 s), and at later times (greater than or equal to 5 min) through the hydrolysis of primarily, if not exclusively, phosphatidylcholine (Pessin, M. S., and Raben, D. M. (1989) J. Biol. Phosphatidylcholines 210-229 coagulation factor II, thrombin Homo sapiens 121-129 2358751-0 1990 Lipopolysaccharide (LPS) alters phosphatidylcholine metabolism in elicited peritoneal macrophages. Phosphatidylcholines 32-51 toll-like receptor 4 Mus musculus 20-23 2188971-0 1990 Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Phosphatidylcholines 42-61 KRAS proto-oncogene, GTPase Homo sapiens 76-82 2188971-4 1990 Here we use a mutant of Ki-ras which is temperature-sensitive for transformation to investigate the kinetics of activation of the phosphodiesterase-mediated turnover of phosphatidylcholine. Phosphatidylcholines 169-188 KRAS proto-oncogene, GTPase Homo sapiens 24-30 2248600-6 1990 In studies with human fetal lung in organ culture, we have observed that glucocorticoids, in combination with prolactin and/or insulin, increase the rate of lamellar body phosphatidylcholine synthesis and alter lamellar body glycerophospholipid composition to one reflective of surfactant secreted by the human fetal lung at term. Phosphatidylcholines 171-190 insulin Homo sapiens 127-134 2373243-0 1990 Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism. Phosphatidylcholines 54-73 gastrin releasing peptide Homo sapiens 0-8 2116167-2 1990 Kinetic analyses showed a marked increase in the affinity of t-PA for Lys-plasminogen in the presence of heparin-inserted phosphatidylcholine (PC) liposomes. Phosphatidylcholines 122-141 plasminogen activator, tissue type Homo sapiens 61-65 2116167-2 1990 Kinetic analyses showed a marked increase in the affinity of t-PA for Lys-plasminogen in the presence of heparin-inserted phosphatidylcholine (PC) liposomes. Phosphatidylcholines 143-145 plasminogen activator, tissue type Homo sapiens 61-65 2335511-6 1990 Using measurements of radiolabeled headgroup release and molecular species analysis, we previously determined that alpha-thrombin generates diglycerides through the hydrolysis of both the phosphoinositides and phosphatidylcholine at early times (15 s), and at later times (greater than or equal to 5 min) through the hydrolysis of primarily, if not exclusively, phosphatidylcholine (Pessin, M. S., and Raben, D. M. (1989) J. Biol. Phosphatidylcholines 362-381 coagulation factor II, thrombin Homo sapiens 121-129 1693743-1 1990 Enzymatically active, detergent-solubilized purified hormone-sensitive lipase (HSL) was incorporated into phosphatidylcholine (PC) vesicles, using a detergent-dialysis procedure with small PC vesicles, obtained by sonication, as phospholipid source and CHAPS, a zwitterionic bile-salt derivative, as detergent. Phosphatidylcholines 106-125 lipase E, hormone sensitive type Homo sapiens 53-77 2159807-7 1990 A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels. Phosphatidylcholines 281-300 spindlin 1 Homo sapiens 110-114 2159807-7 1990 A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels. Phosphatidylcholines 281-300 spindlin 1 Homo sapiens 152-156 2159807-7 1990 A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels. Phosphatidylcholines 281-300 spindlin 1 Homo sapiens 152-156 2340304-6 1990 Results with human platelet cytosol were highly suggestive for the presence of an arachidonoyl-selective phospholipase A2 when separate phosphatidylcholine species were assayed. Phosphatidylcholines 136-155 phospholipase A2 group IB Homo sapiens 105-121 2159807-7 1990 A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels. Phosphatidylcholines 75-94 spindlin 1 Homo sapiens 152-156 2159807-7 1990 A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels. Phosphatidylcholines 75-94 spindlin 1 Homo sapiens 152-156 2373740-5 1990 In accordance with this, C-CAM was effectively incorporated into phosphatidylcholine liposomes by dialysis from octylglucoside-containing solutions. Phosphatidylcholines 65-84 CEA cell adhesion molecule 1 Rattus norvegicus 25-30 2398032-3 1990 Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine). Phosphatidylcholines 189-208 interleukin 1 alpha Homo sapiens 29-39 1693743-1 1990 Enzymatically active, detergent-solubilized purified hormone-sensitive lipase (HSL) was incorporated into phosphatidylcholine (PC) vesicles, using a detergent-dialysis procedure with small PC vesicles, obtained by sonication, as phospholipid source and CHAPS, a zwitterionic bile-salt derivative, as detergent. Phosphatidylcholines 106-125 lipase E, hormone sensitive type Homo sapiens 79-82 2339422-2 1990 After 5 days of ACR administration (50 mg/kg/day) an increase in the incorporation of 32P into phosphatidylinositol-4,5-bisphosphate, phosphatidylinositol-4-phosphate, and phosphatidylcholine was detected in proximal sciatic nerve segments. Phosphatidylcholines 172-191 acrosin Rattus norvegicus 16-19 2156839-0 1990 Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene. Phosphatidylcholines 8-27 Harvey rat sarcoma virus oncogene Mus musculus 79-89 2108726-1 1990 Lipid transfer between human plasma low-density lipoprotein (LDL) and an LDL-size microemulsion of triolein and phosphatidylcholine stabilized with human apolipoprotein A-I was catalyzed by the lipid transfer particle from hemolymph of the tobacco hornworm (Manduca sexta). Phosphatidylcholines 112-131 apolipoprotein A1 Homo sapiens 154-172 2322573-4 1990 HDL subfractions were then treated with or without phospholipase A2 from Crotalus adamanteus in presence of albumin leading to a 72-82% phosphatidylcholine degradation. Phosphatidylcholines 136-155 phospholipase A2 group IB Homo sapiens 51-67 2156839-1 1990 The effect of expression of the Harvey-ras oncogene on phosphatidylcholine metabolism in C3H10T1/2 mouse fibroblast cells was examined. Phosphatidylcholines 55-74 Harvey rat sarcoma virus oncogene Mus musculus 32-42 2159335-6 1990 By use of the same technique for model membranes, it was shown that in phosphatidylcholine bilayers the collision frequency of the three fluorescent phosphoinositides decreased in the order PI greater than PIP greater than PIP2. Phosphatidylcholines 71-90 prolactin induced protein Homo sapiens 206-209 2159287-6 1990 Studies of phospholipid metabolism strongly suggested that phosphatidylcholine was the source of the 1,2-diacylglycerol generated in response to EGF. Phosphatidylcholines 59-78 epidermal growth factor Homo sapiens 145-148 2159287-8 1990 This pattern of sustained 1,2-diacylglycerol formation from phosphatidylcholine may be important in the mitogenic signalling of EGF and potentially other growth factors. Phosphatidylcholines 60-79 epidermal growth factor Homo sapiens 128-131 2138608-1 1990 Studies are reported on the inhibition of phospholipase A2 (PLA2) from porcine pancreas, cobra (Naja naja) venom, and the P388D1 macrophage-like cell line by human recombinant lipocortin I and bovine lung calpactin I. Membrane vesicles prepared from 1-stearoyl,2-arachidonoyl phosphatidylcholine (PC) and other PCs were utilized as substrate. Phosphatidylcholines 297-299 phospholipase A2 group IB Homo sapiens 42-58 2138608-1 1990 Studies are reported on the inhibition of phospholipase A2 (PLA2) from porcine pancreas, cobra (Naja naja) venom, and the P388D1 macrophage-like cell line by human recombinant lipocortin I and bovine lung calpactin I. Membrane vesicles prepared from 1-stearoyl,2-arachidonoyl phosphatidylcholine (PC) and other PCs were utilized as substrate. Phosphatidylcholines 297-299 phospholipase A2 group IB Homo sapiens 60-64 2158306-1 1990 Previous studies showed that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells [Kolesnick (1987) J. Biol. Phosphatidylcholines 95-114 thyrotropin releasing hormone Rattus norvegicus 48-77 2139793-5 1990 The tryptophan fluorescence of bound lipocortin I was nearly unaffected by substituting the quencher 1-palmitoyl-2-(5-doxylstearoyl)-sn-glycero-3-phosphocholine (5-PC) for egg phosphatidylcholine, while that of the lipocortin V tryptophan was quenched significantly. Phosphatidylcholines 176-195 annexin A1 Bos taurus 37-49 2333953-1 1990 The phosphatidylcholine-specific transfer protein (PC-Tp) from bovine liver was used to replace endogeneous erythrocyte phosphatidylcholine (PC) with various amounts of five different molecular species of PC. Phosphatidylcholines 4-23 phosphatidylcholine transfer protein Bos taurus 51-56 2140896-1 1990 Expression of functionally active bovine visual rhodopsin was achieved by sequential transcription and translation in vitro of rhodopsin gene cDNA with co-translational insertion of the protein into phosphatidylcholine liposomes. Phosphatidylcholines 199-218 rhodopsin Bos taurus 48-57 2358187-2 1990 Upon interaction of CaM with egg phosphatidylcholine and asolectin BLM the parameter E perpendicular grew slightly (not more than by 10% as compared to the respective vale for nonmodified BLM), suggesting a weak effect on the ordering of the hydrophobic moiety of the lipid bilayer. Phosphatidylcholines 33-52 calmodulin 1 Homo sapiens 20-23 2337575-4 1990 PC/PS mixtures show a pronounced tendency to form metastable solutions in the presence of calcium, particularly when they contain less than equimolar proportions of PS. Phosphatidylcholines 0-2 surfactant protein C Homo sapiens 3-5 2337575-6 1990 Different PS species exhibit different apparent residual solubilities in liquid-crystalline PC bilayers, ranging from less than 10 mol % for dimyristoyl-PS to ca. Phosphatidylcholines 92-94 surfactant protein C Homo sapiens 10-12 2337575-4 1990 PC/PS mixtures show a pronounced tendency to form metastable solutions in the presence of calcium, particularly when they contain less than equimolar proportions of PS. Phosphatidylcholines 0-2 surfactant protein C Homo sapiens 165-167 2108162-3 1990 EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 139-158 epidermal growth factor like 1 Rattus norvegicus 0-3 2155032-1 1990 The effects of cholesterol on the dynamics of cholestane spin probe (CSL) in various phosphatidylcholine-cholesterol mixed model membranes are examined. Phosphatidylcholines 85-104 chorionic somatomammotropin hormone like 1 Homo sapiens 69-72 2108162-3 1990 EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 139-158 phospholipase A2 group IB Rattus norvegicus 13-17 2155238-2 1990 Mutations at the INO4 locus result in a decrease in phosphatidylcholine synthesis and an inability to derepress the structural genes for inositol-1-phosphate synthase and phosphatidylserine synthase. Phosphatidylcholines 52-71 Ino4p Saccharomyces cerevisiae S288C 17-21 2155224-0 1990 Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine. Phosphatidylcholines 122-141 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 23-62 1968928-4 1990 This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates. Phosphatidylcholines 92-111 phospholipase A2 group IB Homo sapiens 75-79 1968928-4 1990 This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates. Phosphatidylcholines 92-111 phospholipase A2 group IB Homo sapiens 280-284 1968928-4 1990 This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates. Phosphatidylcholines 92-111 phospholipase A2 group IB Homo sapiens 280-284 1968928-4 1990 This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates. Phosphatidylcholines 204-223 phospholipase A2 group IB Homo sapiens 75-79 2303476-2 1990 Equilibrium binding studies of prothrombinase complex formation were undertaken using phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine (PCPS), factor Va, and factor Xa modified with dansyl glutamylglycinylarginyl chloromethyl ketone (DEGR.Xa). Phosphatidylcholines 120-139 coagulation factor X Homo sapiens 31-45 2317195-0 1990 P2-purinoceptor regulation of surfactant phosphatidylcholine secretion. Phosphatidylcholines 41-60 pyrimidinergic receptor P2Y6 Homo sapiens 0-15 2317195-11 1990 These results are consistent with a prominent role for protein kinase C in regulation of P2-purinoceptor-induced surfactant phosphatidylcholine secretion, and indicate that Ca2+ mobilization is not a necessary step for ATP-induced surfactant phosphatidylcholine secretion. Phosphatidylcholines 124-143 pyrimidinergic receptor P2Y6 Homo sapiens 89-104 2357235-3 1990 Functional expression of bovine visual rhodopsin in the cell-free translation system with cotranslational insertion of the protein into phosphatidylcholine liposomes is described. Phosphatidylcholines 136-155 rhodopsin Bos taurus 39-48 2102782-0 1990 Effect of prolactin on phosphatidylcholine hydrolysis via phospholipase C in isolated adrenocortical cells of guinea pig. Phosphatidylcholines 23-42 prolactin Cavia porcellus 10-19 2155031-0 1990 Stimulation of CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis by incubation of rat hepatocytes with phospholipase A2. Phosphatidylcholines 60-79 phospholipase A2 group IB Rattus norvegicus 128-144 2155031-1 1990 The effect of phospholipase A2 treatment of rat hepatocytes on CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis was investigated. Phosphatidylcholines 108-127 phospholipase A2 group IB Rattus norvegicus 14-30 2155031-7 1990 Incubation of hepatocytes in the presence of phospholipase A2 (0.9 units/dish) for 10 min prior to pulse-chase experiments resulted in an increase in radiolabel incorporation into phosphatidylcholine (from 2.4 +/- 0.02.10(-5) dpm/dish to 3.1 +/- 0.1.10(-5) dpm/dish) and a corresponding decrease in radiolabel associated with the choline (from 2.5 +/- 0.05.10(-5) to 1.4 +/- 0.03.10(-5) dpm) and phosphocholine fractions (from 8.5 +/- 0.07.10(-5) to 6.9 +/- 0.05.10(-5) dpm). Phosphatidylcholines 180-199 phospholipase A2 group IB Rattus norvegicus 45-61 2155031-8 1990 We conclude that phospholipase A2 can cause a stimulation of CTP: phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in cultured rat hepatocytes. Phosphatidylcholines 115-134 phospholipase A2 group IB Rattus norvegicus 17-33 2301861-6 1990 Female fetal rat lung tissue exposed to recombinant MIS (10(-9) M, 10(-8) M) revealed depressed disaturated phosphatidylcholine content both 48 and 72 h after injection compared with female vehicle-injected littermates. Phosphatidylcholines 108-127 anti-Mullerian hormone Rattus norvegicus 52-55 2111711-6 1990 Based upon these results, we also conclude that the combined hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 serves as a major source for eicosanoid biosynthesis in thrombin-stimulated human platelets. Phosphatidylcholines 75-94 phospholipase A2 group IB Homo sapiens 123-139 2111711-6 1990 Based upon these results, we also conclude that the combined hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 serves as a major source for eicosanoid biosynthesis in thrombin-stimulated human platelets. Phosphatidylcholines 75-94 coagulation factor II, thrombin Homo sapiens 196-204 2135667-7 1990 In [3H]ethanolamine-prelabeled cells, but not in [3H]choline-prelabeled cells, PHA, CD3 and CD2 induced the breakdown of PC. Phosphatidylcholines 121-123 CD2 molecule Homo sapiens 92-95 2105749-0 1990 Interaction of apolipoprotein A-II with recombinant HDL containing egg phosphatidylcholine, unesterified cholesterol and apolipoprotein A-I. Phosphatidylcholines 71-90 apolipoprotein A1 Homo sapiens 15-33 2305899-10 1990 We suggest that adenosine deaminase stimulates phosphatidylcholine secretion by removing adenosine that occupies A1 receptors, thus reversing inhibition of cAMP-mediated secretion. Phosphatidylcholines 47-66 adenosine deaminase Rattus norvegicus 16-35 2305210-3 1990 The influence of bile salts was thus similar to that which has earlier been described for the hydrolysis of phosphatidylcholine (PC) with pig pancreatic phospholipase A2. Phosphatidylcholines 108-127 phospholipase A2 group IB Homo sapiens 153-169 2305210-3 1990 The influence of bile salts was thus similar to that which has earlier been described for the hydrolysis of phosphatidylcholine (PC) with pig pancreatic phospholipase A2. Phosphatidylcholines 129-131 phospholipase A2 group IB Homo sapiens 153-169 2369553-1 1990 We determined whether transforming growth factor-beta 1 (TGF-beta 1) encapsulated in phosphatidylcholine and phosphatidylserine liposomes could inhibit the proliferative response of mouse liver subsequent to partial hepatectomy. Phosphatidylcholines 85-104 transforming growth factor, beta 1 Mus musculus 22-55 2298300-3 1990 These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous 31P NMR studies) and histological modifications demonstrated that at early stages of TNF-induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products. Phosphatidylcholines 411-430 tumor necrosis factor Mus musculus 229-232 2105091-5 1990 This is the first time a peptide activator for LCAT that rivals the activity of apo A-I in the vesicular and discoidal egg phosphatidylcholine assay systems has been synthesized. Phosphatidylcholines 123-142 lecithin-cholesterol acyltransferase Homo sapiens 47-51 2105091-5 1990 This is the first time a peptide activator for LCAT that rivals the activity of apo A-I in the vesicular and discoidal egg phosphatidylcholine assay systems has been synthesized. Phosphatidylcholines 123-142 apolipoprotein A1 Homo sapiens 80-87 2129785-4 1990 Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures. Phosphatidylcholines 129-149 interleukin 1 beta Rattus norvegicus 17-27 2154211-2 1990 PAF ranging in concentration from 10(-6)-10(-9)M initiated the incorporation of 32P into phosphatidic acid (PA) and phosphatidylinositol (PI) with no change in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) over baseline. Phosphatidylcholines 194-213 PCNA clamp associated factor Homo sapiens 0-3 2154211-2 1990 PAF ranging in concentration from 10(-6)-10(-9)M initiated the incorporation of 32P into phosphatidic acid (PA) and phosphatidylinositol (PI) with no change in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) over baseline. Phosphatidylcholines 215-217 PCNA clamp associated factor Homo sapiens 0-3 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 24-43 cut-like homeobox 1 Rattus norvegicus 85-88 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 24-43 cut-like homeobox 1 Rattus norvegicus 177-180 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 123-142 cut-like homeobox 1 Rattus norvegicus 85-88 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 123-142 cut-like homeobox 1 Rattus norvegicus 177-180 2153111-3 1990 In the presence of phosphatidylcholine transfer protein, the incorporation of CDP-choline into phosphatidylcholine was markedly stimulated. Phosphatidylcholines 19-38 cut-like homeobox 1 Rattus norvegicus 78-81 2350485-3 1990 From 3 to 17 mol% of phosphatidylcholine, selectively deuterated at various positions along the sn-2-acyl chain, was transferred from unilamellar vesicles to VLDL using a partially purified phosphatidylcholine transfer protein. Phosphatidylcholines 21-40 CD320 antigen Mus musculus 158-162 2350485-3 1990 From 3 to 17 mol% of phosphatidylcholine, selectively deuterated at various positions along the sn-2-acyl chain, was transferred from unilamellar vesicles to VLDL using a partially purified phosphatidylcholine transfer protein. Phosphatidylcholines 190-209 CD320 antigen Mus musculus 158-162 2369553-1 1990 We determined whether transforming growth factor-beta 1 (TGF-beta 1) encapsulated in phosphatidylcholine and phosphatidylserine liposomes could inhibit the proliferative response of mouse liver subsequent to partial hepatectomy. Phosphatidylcholines 85-104 transforming growth factor, beta 1 Mus musculus 57-67 2402761-7 1990 The melittin-stimulated PLA2 activity observed in cells was primarily associated with phosphatidylcholine. Phosphatidylcholines 86-105 phospholipase A2 group IB Homo sapiens 24-28 2073400-2 1990 A novel method for determination of PLA2 activity in intact cell membranes with a fluorescent analogue of phosphatidylcholine, was employed. Phosphatidylcholines 106-125 phospholipase A2 group IIA Homo sapiens 36-40 2110108-1 1990 The role of NADPH--cytochrome P450 reductase and cytochrome P450 in NADPH- and ADP--Fe3(+)-dependent lipid peroxidation was investigated by using the purified enzymes and liposomes prepared from either total rat-liver phospholipids or a mixture of bovine phosphatidyl choline and phosphatidyl ethanolamine (PC/PE liposomes). Phosphatidylcholines 255-275 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 19-34 2307391-2 1990 Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours. Phosphatidylcholines 113-133 prolactin Mus musculus 40-43 2307391-2 1990 Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours. Phosphatidylcholines 135-137 prolactin Mus musculus 40-43 33809964-7 2021 By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine. Phosphatidylcholines 209-228 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 17-62 3233222-3 1988 Membranes composed of a mixture of phosphatidylcholine (PC) and positively charged lipids like stearylamine, sphingosine, or hexadecyltrimethylammonium bromide caused a more than 1000-fold increase of the rate of prothrombin activation. Phosphatidylcholines 35-54 coagulation factor II, thrombin Homo sapiens 213-224 3233222-3 1988 Membranes composed of a mixture of phosphatidylcholine (PC) and positively charged lipids like stearylamine, sphingosine, or hexadecyltrimethylammonium bromide caused a more than 1000-fold increase of the rate of prothrombin activation. Phosphatidylcholines 56-58 coagulation factor II, thrombin Homo sapiens 213-224 3233222-7 1988 Calcium ions strongly inhibited prothrombin activation on vesicles composed of PC and stearylamine (80/20 M/M), which indicates that the regions of prothrombin and/or factor Xa containing gamma-carboxyglutamic acid (gla) are important for the interaction of these proteins with positively charged membranes. Phosphatidylcholines 79-81 coagulation factor II, thrombin Homo sapiens 32-43 33794068-7 2021 Moreover, in the absence of SMAC/Diablo, PSD inhibited cancer cell proliferation by catalysing the overproduction of mitochondrial PE and depleting the cellular levels of PC, PE and PS. Phosphatidylcholines 171-173 F-box and leucine rich repeat protein 15 Homo sapiens 41-44 33818269-11 2021 PNPLA6-related disorders are a phenotypically highly heterogenous group where alterations in the phosphatidylcholine metabolism can lead to manifestations in different tissues with no clear genotype-phenotype correlation. Phosphatidylcholines 97-116 patatin like phospholipase domain containing 6 Homo sapiens 0-6 33794068-6 2021 As a result, PSD activity and mitochondrial PE levels were increased in the mitochondria of SMAC/Diablo-deficient cancer cells, with the total amount of cellular phospholipids and phosphatidylcholine (PC) being lower as compared to SMAC-expressing cancer cells. Phosphatidylcholines 180-199 diablo IAP-binding mitochondrial protein Homo sapiens 92-96 33794068-6 2021 As a result, PSD activity and mitochondrial PE levels were increased in the mitochondria of SMAC/Diablo-deficient cancer cells, with the total amount of cellular phospholipids and phosphatidylcholine (PC) being lower as compared to SMAC-expressing cancer cells. Phosphatidylcholines 201-203 diablo IAP-binding mitochondrial protein Homo sapiens 92-96 33809964-7 2021 By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine. Phosphatidylcholines 209-228 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 64-68 20705608-3 2010 Mouse cPLA(2)beta action on phosphatidylcholine vesicles is activated by anionic phosphoinositides and cardiolipin but displays a requirement for Ca(2+) only in the presence of cardiolipin. Phosphatidylcholines 28-47 phospholipase A2, group IVB (cytosolic) Mus musculus 6-17 24777581-8 2014 On the other hand, the loss of HL, EL, or both raised the plasma concentrations for select molecular species of phosphatidylcholine, cholesteryl ester, diacylglycerol, sphingomyelin, ceramide, plasmanylcholine, and plasmenylcholine. Phosphatidylcholines 112-131 lipase, hepatic Mus musculus 31-33 34808333-5 2022 Lipidomic analysis showed that FOXM1 increased unsaturated triglyceride (TG) and phosphatidylcholine (PC) abundance, which are the main components of lipid droplet (LD). Phosphatidylcholines 81-100 forkhead box M1 Mus musculus 31-36 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 158-177 hemoglobin subunit gamma 2 Homo sapiens 44-57 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 158-177 cytochrome c, somatic Homo sapiens 69-81 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 158-177 cytochrome c, somatic Homo sapiens 83-88 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 179-181 hemoglobin subunit gamma 2 Homo sapiens 44-57 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 179-181 cytochrome c, somatic Homo sapiens 69-81 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Phosphatidylcholines 179-181 cytochrome c, somatic Homo sapiens 83-88 19517528-5 2009 Newly synthesized PC by PEMT2 contained more acyl groups of oleic acid (P < 0.01) and was mainly located in mitochondria; pemt2 over-expression increased the mitochondrial membrane fluidity and the release of cytochrome C from the mitochondria into the cytoplasma, which in turn activated caspase-9 and caspase-3, the key molecules in the mitochondrial apoptotic pathway. Phosphatidylcholines 18-20 caspase 9 Rattus norvegicus 292-301 19517528-5 2009 Newly synthesized PC by PEMT2 contained more acyl groups of oleic acid (P < 0.01) and was mainly located in mitochondria; pemt2 over-expression increased the mitochondrial membrane fluidity and the release of cytochrome C from the mitochondria into the cytoplasma, which in turn activated caspase-9 and caspase-3, the key molecules in the mitochondrial apoptotic pathway. Phosphatidylcholines 18-20 caspase 3 Rattus norvegicus 306-315 10330032-7 1999 The MBP-induced increase in PC secretion was significantly reduced by preadministration of either H-7, a protein kinase inhibitor, or 1, 2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-AM, a chelator of intracellular Ca2+, but not by H-89, a protein kinase inhibitor. Phosphatidylcholines 28-30 myelin basic protein Rattus norvegicus 4-7 10330032-8 1999 Our results suggest that the MBP-induced increase in PC secretion may provide mechanical stability and protect against lung atelectasis. Phosphatidylcholines 53-55 myelin basic protein Rattus norvegicus 29-32 34808333-5 2022 Lipidomic analysis showed that FOXM1 increased unsaturated triglyceride (TG) and phosphatidylcholine (PC) abundance, which are the main components of lipid droplet (LD). Phosphatidylcholines 102-104 forkhead box M1 Mus musculus 31-36 34846128-7 2021 The binding of PI(4,5)P2 modified with a fluorophore to Kir3.2 can be enhanced by other lipids, such as phosphatidylcholine. Phosphatidylcholines 104-123 potassium inwardly rectifying channel subfamily J member 6 Homo sapiens 56-62 34866326-3 2022 Here, we perform quantitative phosphoproteomics and phospholipid analysis and find that PfCDPK7 promotes phosphatidylcholine (PC) synthesis by regulating two key enzymes involved in PC synthesis, phosphoethanolamine-N-methyltransferase (PMT) and ethanolamine kinase (EK). Phosphatidylcholines 105-124 choline kinase alpha Homo sapiens 246-265 34944757-4 2021 METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI). Phosphatidylcholines 204-223 low density lipoprotein receptor Homo sapiens 27-29 34944757-4 2021 METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI). Phosphatidylcholines 204-223 low density lipoprotein receptor Homo sapiens 94-106 34944757-4 2021 METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI). Phosphatidylcholines 225-227 low density lipoprotein receptor Homo sapiens 27-29 34944757-4 2021 METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI). Phosphatidylcholines 225-227 low density lipoprotein receptor Homo sapiens 94-106 34929484-5 2022 Amino acid sequence segmentation analysis indicated that the K-segment of AtHIRD11 inhibited the cryoaggregation of phosphatidylcholine (PC) liposomes but other segments did not. Phosphatidylcholines 116-135 dehydrin family protein Arabidopsis thaliana 74-82 34929484-5 2022 Amino acid sequence segmentation analysis indicated that the K-segment of AtHIRD11 inhibited the cryoaggregation of phosphatidylcholine (PC) liposomes but other segments did not. Phosphatidylcholines 137-139 dehydrin family protein Arabidopsis thaliana 74-82 34866326-3 2022 Here, we perform quantitative phosphoproteomics and phospholipid analysis and find that PfCDPK7 promotes phosphatidylcholine (PC) synthesis by regulating two key enzymes involved in PC synthesis, phosphoethanolamine-N-methyltransferase (PMT) and ethanolamine kinase (EK). Phosphatidylcholines 126-128 choline kinase alpha Homo sapiens 246-265 34322898-11 2021 Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2. Phosphatidylcholines 104-123 peroxiredoxin 1 Mus musculus 26-31 34419589-7 2021 Cellular phosphatidylcholine/phosphatidylethanolamine ratio was decreased only upon overexpression of the proteins, potentially contributing to altered ApoB100 assembly and secretion. Phosphatidylcholines 9-28 apolipoprotein B Homo sapiens 152-159 34416390-2 2021 StarD7 is a lipid transport protein involved in the phosphatidylcholine (PC) delivery to mitochondria. Phosphatidylcholines 52-71 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 34416390-2 2021 StarD7 is a lipid transport protein involved in the phosphatidylcholine (PC) delivery to mitochondria. Phosphatidylcholines 73-75 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 34416390-6 2021 StarD7.I (D7.I) stable cells were able to transport higher fluorescent PC analog to mitochondria than Ct cells, yield mitochondrial fusions, maintained the membrane potential, and produced lower levels of reactive oxygen species (ROS). Phosphatidylcholines 71-73 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 34322898-11 2021 Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2. Phosphatidylcholines 104-123 glycerophosphodiester phosphodiesterase domain containing 5 Mus musculus 90-95 34322898-11 2021 Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2. Phosphatidylcholines 104-123 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 153-158 34849527-8 2021 Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 134-153 phosphatidylethanolamine N-methyltransferase Homo sapiens 71-115 34774525-0 2021 Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity. Phosphatidylcholines 40-59 sphingomyelin synthase 1 Mus musculus 0-31 34774525-3 2021 Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity. Phosphatidylcholines 262-264 sphingomyelin synthase 1 Homo sapiens 141-145 34774525-3 2021 Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity. Phosphatidylcholines 262-264 sphingomyelin synthase 2 Homo sapiens 150-154 34774525-3 2021 Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity. Phosphatidylcholines 262-264 sphingomyelin synthase 1 Homo sapiens 292-296 34774525-3 2021 Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity. Phosphatidylcholines 262-264 sphingomyelin synthase 2 Homo sapiens 301-305 34774525-7 2021 Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine. Phosphatidylcholines 148-150 sphingomyelin synthase 1 Mus musculus 31-35 34774525-7 2021 Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine. Phosphatidylcholines 148-150 sphingomyelin synthase 2 Homo sapiens 40-44 34774525-7 2021 Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine. Phosphatidylcholines 148-150 sphingomyelin synthase 1 Mus musculus 120-124 34774525-7 2021 Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine. Phosphatidylcholines 148-150 sphingomyelin synthase 2 Homo sapiens 129-133 34849527-8 2021 Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 134-153 phosphatidylethanolamine N-methyltransferase Homo sapiens 117-121 34849527-8 2021 Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 155-157 phosphatidylethanolamine N-methyltransferase Homo sapiens 71-115 34849527-8 2021 Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 155-157 phosphatidylethanolamine N-methyltransferase Homo sapiens 117-121 34876384-6 2022 The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model. Phosphatidylcholines 54-73 phospholipase D1 Homo sapiens 11-27 34876384-6 2022 The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model. Phosphatidylcholines 54-73 phospholipase D1 Homo sapiens 29-33 34772952-6 2021 Molecular dynamics simulations revealed that a Tyr-Pro molecule was stably positioned in the two potential binding pockets (sites 1 and 2) of the seven-transmembrane receptor, AdipoR1, anchored in a virtual 1-palmitoyl-2-oleoyl-phosphatidylcholine membrane. Phosphatidylcholines 228-247 adiponectin receptor 1 Homo sapiens 176-183 34778899-8 2021 GMCSFRbeta KO mice reproduced the histopathological and biochemical features of PAP, accumulating surfactant PC in both broncho-alveolar lavage fluid (BALF) and lavaged lung tissue. Phosphatidylcholines 109-111 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) Mus musculus 0-10 34107287-1 2021 ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. Phosphatidylcholines 104-123 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34686867-5 2021 Ablation of XBP1 expression with genetic manipulation or ameliorating ER stress responses by facilitating LPCAT3-mediated incorporation of unsaturated lipids to the phosphatidylcholine hampered pro-tumorigenic phenotype and survival in TAMs. Phosphatidylcholines 165-184 X-box binding protein 1 Homo sapiens 12-16 34686867-5 2021 Ablation of XBP1 expression with genetic manipulation or ameliorating ER stress responses by facilitating LPCAT3-mediated incorporation of unsaturated lipids to the phosphatidylcholine hampered pro-tumorigenic phenotype and survival in TAMs. Phosphatidylcholines 165-184 lysophosphatidylcholine acyltransferase 3 Homo sapiens 106-112 34520050-3 2021 The requirement for PC is suppressed by monosomy of chromosome XV or by a point mutation in the ACC1 gene encoding acetyl-CoA carboxylase. Phosphatidylcholines 20-22 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 96-100 34684619-10 2021 CONCLUSIONS: The binding of aromatic acids to phosphatidylcholine increases their beneficial effect on insulin sensitivity in adipocytes and expands their potential practical application as nutraceutical health-promoting agents. Phosphatidylcholines 46-65 insulin Homo sapiens 103-110 34748631-3 2022 Evaluating the association of correlations among metabolites and/or lipids with age, we found that phosphatidylcholines correlations tend to have a positive trend associated with age in women, and monoacylglycerols and lysophosphatidylcholines correlations tend to have a negative trend associated with age in men. Phosphatidylcholines 99-119 renin binding protein Homo sapiens 80-83 34748631-3 2022 Evaluating the association of correlations among metabolites and/or lipids with age, we found that phosphatidylcholines correlations tend to have a positive trend associated with age in women, and monoacylglycerols and lysophosphatidylcholines correlations tend to have a negative trend associated with age in men. Phosphatidylcholines 99-119 renin binding protein Homo sapiens 179-182 34748631-4 2022 The association of ratio between molecular features with age reveals that the ratio between decanoyl L-carnitine and lysophosphatidylcholine in women have a negative association with age, while the ratios between L-carnitine, L-acetylcarnitine, and phosphatidylcholines in men have a positive association with age. Phosphatidylcholines 249-269 renin binding protein Homo sapiens 57-60 34748631-4 2022 The association of ratio between molecular features with age reveals that the ratio between decanoyl L-carnitine and lysophosphatidylcholine in women have a negative association with age, while the ratios between L-carnitine, L-acetylcarnitine, and phosphatidylcholines in men have a positive association with age. Phosphatidylcholines 249-269 renin binding protein Homo sapiens 310-313 34418535-1 2021 Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of phosphatidylcholine to ceramide in mammals. Phosphatidylcholines 165-184 sphingomyelin synthase 1 Homo sapiens 63-67 34418535-1 2021 Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of phosphatidylcholine to ceramide in mammals. Phosphatidylcholines 165-184 sphingomyelin synthase 2 Homo sapiens 72-76 34379812-7 2021 The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA. Phosphatidylcholines 28-47 clasper Mus musculus 13-16 34379812-7 2021 The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA. Phosphatidylcholines 28-47 clasper Mus musculus 49-52 34379812-7 2021 The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA. Phosphatidylcholines 28-47 clasper Mus musculus 106-109 34868703-0 2021 DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells. Phosphatidylcholines 13-32 peroxisome proliferator activated receptor gamma Homo sapiens 71-80 34868703-0 2021 DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells. Phosphatidylcholines 13-32 kinase insert domain receptor Homo sapiens 100-106 34868703-0 2021 DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells. Phosphatidylcholines 13-32 mitogen-activated protein kinase 1 Homo sapiens 111-114 34676404-7 2021 We propose that PMT1 and PMT2 are induced by P starvation to produce PCho mainly for leaf growth maintenance, rather than for phosphatidylcholine biosynthesis, in membrane lipid remodeling. Phosphatidylcholines 126-145 polyol/monosaccharide transporter 2 Arabidopsis thaliana 25-29 34107287-1 2021 ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. Phosphatidylcholines 125-127 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 tumor necrosis factor Homo sapiens 102-129 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 tumor necrosis factor Homo sapiens 131-140 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 143-161 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 163-166 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 interleukin 6 Homo sapiens 173-186 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 interleukin 6 Homo sapiens 188-192 34607314-9 2021 Phosphatidylcholines, cholesteryl ester, cholesterol, ceramide-1-phosphate, and CCL5 expression were significantly higher in aged WT mice than in aged Postn-null mice. Phosphatidylcholines 0-20 periostin, osteoblast specific factor Mus musculus 151-156 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 tumor necrosis factor Homo sapiens 102-129 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 tumor necrosis factor Homo sapiens 131-140 34607314-11 2021 Lysophosphatidylcholine acyltransferase 2, which converts lysophosphatidylcholine to phosphatidylcholine, was significantly higher in aged WT mice than in aged Postn-null mice. Phosphatidylcholines 85-104 lysophosphatidylcholine acyltransferase 2 Mus musculus 0-41 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 C-reactive protein Homo sapiens 143-161 34607314-11 2021 Lysophosphatidylcholine acyltransferase 2, which converts lysophosphatidylcholine to phosphatidylcholine, was significantly higher in aged WT mice than in aged Postn-null mice. Phosphatidylcholines 85-104 periostin, osteoblast specific factor Mus musculus 160-165 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 C-reactive protein Homo sapiens 163-166 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 interleukin 6 Homo sapiens 188-192 34425110-9 2021 Excess retinal de novo lipogenesis - either due to diabetes or due to FAS gain-of-function - was associated with modestly increased levels of palmitate-containing phosphatidylcholine species in synaptic membranes, a finding with as yet uncertain significance. Phosphatidylcholines 163-182 fatty acid synthase Mus musculus 70-73 34197964-5 2021 Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine. Phosphatidylcholines 214-233 lecithin cholesterol acyltransferase Mus musculus 78-114 34197964-5 2021 Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine. Phosphatidylcholines 214-233 lecithin cholesterol acyltransferase Mus musculus 116-120 34197964-5 2021 Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine. Phosphatidylcholines 214-233 lipase, endothelial Mus musculus 123-141 34197964-5 2021 Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine. Phosphatidylcholines 214-233 lipase, hepatic Mus musculus 152-166 34197964-5 2021 Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine. Phosphatidylcholines 214-233 lipase, hepatic Mus musculus 168-170 34499764-3 2021 The level of lyso-PC is regulated primarily by lyso-PC acyltransferase 3 (LPCAT3), which acylates lyso-PC to form phosphatidylcholine. Phosphatidylcholines 114-133 lysophosphatidylcholine acyltransferase 3 Mus musculus 47-72 34499764-3 2021 The level of lyso-PC is regulated primarily by lyso-PC acyltransferase 3 (LPCAT3), which acylates lyso-PC to form phosphatidylcholine. Phosphatidylcholines 114-133 lysophosphatidylcholine acyltransferase 3 Mus musculus 74-80 34324831-4 2021 After substitution of endogenous lipids with lipids having an ability to form liquid ordered (Lo) domains (sphingomyelins) or liquid disordered (Ld) domains (unsaturated phosphatidylcholines (PCs)), we found that the propensity of lipids to form ordered domains is required for high IR activity. Phosphatidylcholines 192-195 insulin receptor Homo sapiens 283-285 34403372-0 2021 A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. Phosphatidylcholines 87-106 ATPase, class VI, type 11A Mus musculus 12-18 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 apolipoprotein E Homo sapiens 173-189 34564389-5 2021 We observed that the LDL-lowering HMGCR rs12916-T allele was negatively associated with plasma phosphatidylcholines and sphingomyelins, and HMGCR expression in AT was correlated with various metabolic and mitochondrial pathways. Phosphatidylcholines 95-115 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 34-39 34490332-4 2021 The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids. Phosphatidylcholines 80-99 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 4-29 34490332-4 2021 The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids. Phosphatidylcholines 101-103 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 4-29 34385322-0 2021 Structures of ABCB4 provide insight into phosphatidylcholine translocation. Phosphatidylcholines 41-60 ATP binding cassette subfamily B member 4 Homo sapiens 14-19 34385322-1 2021 ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi. Phosphatidylcholines 51-70 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34385322-6 2021 Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 4 Homo sapiens 130-135 34385322-8 2021 Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 151-156 34421831-3 2021 Two PC synthesis pathways are known in prokaryotes: the PmtA-catalyzed trimethylation of phosphatidylethanolamine and the direct linkage of choline to CDP-diacylglycerol catalyzed by the PC synthase Pcs. Phosphatidylcholines 4-6 PCS Homo sapiens 199-202 34421831-4 2021 Previous studies have reported that B. abortus and B. melitensis possess non-functional PmtAs and that PC is synthesized exclusively via Pcs in these strains. Phosphatidylcholines 103-105 PCS Homo sapiens 137-140 34445104-7 2021 The conjugates substituted by ANISA and VA, respectively, at both the sn-1 and sn-2 positions of PC, appeared the most promising, since they were effective against the vast majority of metastatic melanoma cell lines. Phosphatidylcholines 97-99 solute carrier family 38 member 3 Homo sapiens 70-74 34445104-7 2021 The conjugates substituted by ANISA and VA, respectively, at both the sn-1 and sn-2 positions of PC, appeared the most promising, since they were effective against the vast majority of metastatic melanoma cell lines. Phosphatidylcholines 97-99 solute carrier family 38 member 5 Homo sapiens 79-83 34445104-10 2021 Again, the conjugates substituted by phenolic acid at both the sn-1 and sn-2 positions of PC seemed to be presumably most bioavailable. Phosphatidylcholines 90-92 solute carrier family 38 member 3 Homo sapiens 63-67 34445104-10 2021 Again, the conjugates substituted by phenolic acid at both the sn-1 and sn-2 positions of PC seemed to be presumably most bioavailable. Phosphatidylcholines 90-92 solute carrier family 38 member 5 Homo sapiens 72-76 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 apolipoprotein E Homo sapiens 191-195 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 amyloid beta precursor protein Homo sapiens 268-280 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 amyloid beta precursor protein Homo sapiens 282-287 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 microtubule associated protein tau Homo sapiens 301-304 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 apolipoprotein E Homo sapiens 173-189 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 apolipoprotein E Homo sapiens 191-195 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 amyloid beta precursor protein Homo sapiens 268-280 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 amyloid beta precursor protein Homo sapiens 282-287 34252282-5 2021 The results suggest that favorable electrostatic interactions of the N-terminal charged residues and the phosphatidylcholine membrane surface are crucial in Abeta-mediated membrane permeation. Phosphatidylcholines 105-124 amyloid beta precursor protein Homo sapiens 157-162 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 microtubule associated protein tau Homo sapiens 301-304 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 102-121 RAS like proto-oncogene A Homo sapiens 17-21 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 102-121 phospholipase D1 Homo sapiens 53-69 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 102-121 phospholipase D1 Homo sapiens 71-75 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 123-125 RAS like proto-oncogene A Homo sapiens 17-21 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 123-125 phospholipase D1 Homo sapiens 53-69 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidylcholines 123-125 phospholipase D1 Homo sapiens 71-75 34221998-12 2021 Majority of fecal lipids including lysophosphatidylcholine and phosphatidylcholine were upregulated in CRPC FMT treated mice, accompanied with enhanced expressions of LPCAT1, RAD51, and DNA-PKcs in mice prostate. Phosphatidylcholines 63-82 RAD51 recombinase Mus musculus 175-180 34396103-7 2021 However, higher levels of seven phosphatidylcholines (lysoPC a C18:2, PC aa C42:0, PC ae C42:3, PC ae C44:3, PC ae C44:4, PC ae C44:5 and PC ae C44:6) were associated with increased brain amyloid-beta deposition. Phosphatidylcholines 32-52 amyloid beta precursor protein Homo sapiens 188-200 34396103-9 2021 Our findings suggest that dysregulation of peripheral phosphatidylcholine metabolism is associated with earlier pathological changes noted in Alzheimer"s disease as measured by brain amyloid-beta deposition as well as later clinical features including changes in memory and executive functioning. Phosphatidylcholines 54-73 amyloid beta precursor protein Homo sapiens 183-195 34396103-10 2021 Perturbations in phosphatidylcholine metabolism may point to issues with membrane restructuring leading to the accumulation of amyloid-beta in the brain. Phosphatidylcholines 17-36 amyloid beta precursor protein Homo sapiens 127-139 34242725-3 2021 Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate. Phosphatidylcholines 156-175 epidermal growth factor receptor Homo sapiens 0-32 34242725-3 2021 Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate. Phosphatidylcholines 156-175 epidermal growth factor receptor Homo sapiens 34-38 34209301-1 2021 ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34209301-1 2021 ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 7-48 34209301-6 2021 Our results indicate that the overexpression of wild type RAB10 or its dominant-active mutant significantly increases the amount of ABCB4 at the plasma membrane expression and its phosphatidylcholine floppase function. Phosphatidylcholines 180-199 RAB10, member RAS oncogene family Homo sapiens 58-63 34209301-6 2021 Our results indicate that the overexpression of wild type RAB10 or its dominant-active mutant significantly increases the amount of ABCB4 at the plasma membrane expression and its phosphatidylcholine floppase function. Phosphatidylcholines 180-199 ATP binding cassette subfamily B member 4 Homo sapiens 132-137 34209301-8 2021 Taken together, our findings suggest that RAB10 regulates the plasma membrane targeting of ABCB4 and consequently its capacity to mediate phosphatidylcholine secretion. Phosphatidylcholines 138-157 RAB10, member RAS oncogene family Homo sapiens 42-47 34209301-8 2021 Taken together, our findings suggest that RAB10 regulates the plasma membrane targeting of ABCB4 and consequently its capacity to mediate phosphatidylcholine secretion. Phosphatidylcholines 138-157 ATP binding cassette subfamily B member 4 Homo sapiens 91-96 34205960-1 2021 Choline kinase (CK) is the enzyme catalyzing the first reaction in CDP-choline pathway for the biosynthesis of phosphatidylcholine. Phosphatidylcholines 111-130 cytidine/uridine monophosphate kinase 1 Homo sapiens 0-19 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 C-C motif chemokine ligand 2 Homo sapiens 74-78 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 C-X-C motif chemokine ligand 8 Homo sapiens 80-84 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 C-C motif chemokine ligand 4 Homo sapiens 86-90 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 vascular endothelial growth factor A Homo sapiens 132-136 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 angiopoietin 1 Homo sapiens 138-143 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 angiopoietin 2 Homo sapiens 145-150 33949005-8 2021 Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis. Phosphatidylcholines 243-262 cystathionine beta-synthase Mus musculus 77-80 34277122-6 2021 Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. Phosphatidylcholines 201-220 carnitine palmitoyltransferase 1C Homo sapiens 50-55 35381375-8 2022 Shotgun lipidomic analysis revealed that ABCA7-HDL had ~20 mol% less phosphatidylcholine and 3-5 times more serine-lipid and phosphatidylinositol than ABCA1-HDL, while ABCA1-HDL contained only ~6 mol% (or ~1.1 times) more cholesterol than ABCA7-HDL. Phosphatidylcholines 69-88 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 41-46 34063660-2 2021 The morphology of the supported lipid bilayer (SLB) consisting of PI and phosphatidylcholine (PC) on a mica substrate was observed with atomic force microscope (AFM). Phosphatidylcholines 73-92 MHC class I polypeptide-related sequence A Homo sapiens 103-107 34063660-2 2021 The morphology of the supported lipid bilayer (SLB) consisting of PI and phosphatidylcholine (PC) on a mica substrate was observed with atomic force microscope (AFM). Phosphatidylcholines 94-96 MHC class I polypeptide-related sequence A Homo sapiens 103-107 35348973-8 2022 Interestingly, the comprehensive analysis of transcriptomics and metabolomics indicated that Asiatic acid inhibited the gene expression of Gpat3 and thereby affected the biosynthesis of the metabolites (1-acyl-Sn-glycerol-3-phosphocholine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine), regulating the glycerophospholipid metabolism pathway and ultimately ameliorating hepatocyte damage. Phosphatidylcholines 240-259 glycerol-3-phosphate acyltransferase 3 Rattus norvegicus 139-144 35381375-10 2022 Overall, these results suggest that ABCA7 lacks specificity for phosphatidylcholine and releases significantly but not dramatically less cholesterol in comparison with ABCA1. Phosphatidylcholines 64-83 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 36-41 35526799-1 2022 LPCAT3, a subtype of lysophosphatidylcholine acyltransferases, is a key enzyme in phosphatidylcholine remodeling pathway and plays a significant role in mediating inflammatory response in mammals. Phosphatidylcholines 82-101 lysophospholipid acyltransferase 5 Larimichthys crocea 0-6 35584570-4 2022 Castor phospholipase A2alpha (RcPLA2) has specificity for HFA-containing phosphatidylcholine. Phosphatidylcholines 73-92 phospholipase A 2A Arabidopsis thaliana 7-28 35584957-2 2022 Egg yolk is one of the sources of phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 34-53 pyruvate carboxylase Homo sapiens 55-57 35231605-2 2022 The aim of this study was to investigate the ability of L. micdadei to utilize extracellular choline for phosphatidylcholine (PC) synthesis and its consequences for the phospholipid composition of its membrane system and the interaction with the human LL-37 peptide. Phosphatidylcholines 126-128 cathelicidin antimicrobial peptide Homo sapiens 252-257 35442170-1 2022 Development of ARDS in influenza A virus (IAV)-infected mice is associated with inhibition of alveolar type II (ATII) epithelial cell de novo phosphatidylcholine synthesis and administration of the phosphatidylcholine precursor CDP-choline attenuates IAV-induced ARDS in mice. Phosphatidylcholines 198-217 cut-like homeobox 1 Mus musculus 228-231 35416329-3 2022 The real-time quantitative polymerase chain reaction and promoter-reporter activity revealed a substantial reduction in OPI3 expression and was supported with decreased phosphatidylcholine (PC) level that is rescued with exogenous choline supplementation in gcr1 cells. Phosphatidylcholines 169-188 transcription regulator GCR1 Saccharomyces cerevisiae S288C 258-262 35380992-5 2022 Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Phosphatidylcholines 123-143 SREBF chaperone Mus musculus 50-54 35380992-5 2022 Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Phosphatidylcholines 123-143 lysophosphatidylcholine acyltransferase 3 Mus musculus 241-282 35380992-5 2022 Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Phosphatidylcholines 123-143 lysophosphatidylcholine acyltransferase 3 Mus musculus 284-290 35416329-3 2022 The real-time quantitative polymerase chain reaction and promoter-reporter activity revealed a substantial reduction in OPI3 expression and was supported with decreased phosphatidylcholine (PC) level that is rescued with exogenous choline supplementation in gcr1 cells. Phosphatidylcholines 190-192 transcription regulator GCR1 Saccharomyces cerevisiae S288C 258-262 35380992-5 2022 Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Phosphatidylcholines 217-236 SREBF chaperone Mus musculus 50-54 35380992-5 2022 Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury. Phosphatidylcholines 217-236 lysophosphatidylcholine acyltransferase 3 Mus musculus 241-282 35380992-6 2022 Supplementation of phosphatidylcholines significantly improved liver injury and ER stress induced by SCAP deletion. Phosphatidylcholines 19-39 SREBF chaperone Mus musculus 101-105 35575618-1 2022 BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues. Phosphatidylcholines 155-174 phosphatidylethanolamine N-methyltransferase Homo sapiens 78-122 35617134-4 2022 Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly. Phosphatidylcholines 61-80 vacuole membrane protein 1 Mus musculus 29-33 35617134-4 2022 Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly. Phosphatidylcholines 82-84 vacuole membrane protein 1 Mus musculus 29-33 35617134-4 2022 Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly. Phosphatidylcholines 146-148 vacuole membrane protein 1 Mus musculus 29-33 35575618-1 2022 BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues. Phosphatidylcholines 155-174 phosphatidylethanolamine N-methyltransferase Homo sapiens 124-128 35575618-1 2022 BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues. Phosphatidylcholines 176-178 phosphatidylethanolamine N-methyltransferase Homo sapiens 78-122 35575618-1 2022 BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues. Phosphatidylcholines 176-178 phosphatidylethanolamine N-methyltransferase Homo sapiens 124-128 35551349-10 2022 The main serum lipids that distinguished both Parkinson"s disease patients and LRRK2 mutation carriers from controls included species of ceramide, triacylglycerol, sphingomyelin, acylcarnitine, phosphatidylcholine and lysophosphatidylethanolamine. Phosphatidylcholines 194-213 leucine rich repeat kinase 2 Homo sapiens 79-84 35574050-2 2023 Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles (NPs) loaded with plasmid DNA (pDNA) encoding transforming growth factor-beta 1 (TGF-beta1) to engineer MSCs for enhanced OA therapy via cartilage regeneration. Phosphatidylcholines 44-63 transforming growth factor, beta 1 Mus musculus 133-166 35560202-2 2022 In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth. Phosphatidylcholines 117-119 polyol/monosaccharide transporter 1 Arabidopsis thaliana 70-74 35560202-2 2022 In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth. Phosphatidylcholines 117-119 polyol/monosaccharide transporter 2 Arabidopsis thaliana 76-80 35560202-5 2022 Here, we show that PLMT is ubiquitously expressed in different organs and localized at the endoplasmic reticulum, where PC is produced. Phosphatidylcholines 120-122 phospholipid N-methyltransferase Arabidopsis thaliana 19-23 35560202-6 2022 Overexpression of PLMT in planta increased the content of phospholipids including PC and affected vegetative but not reproductive growth. Phosphatidylcholines 82-84 phospholipid N-methyltransferase Arabidopsis thaliana 18-22 35560202-9 2022 We conclude that PLMT might be a functional enzyme in PC biosynthesis and play an organ-specific role in developing seeds, where rapid accumulation of triacylglycerol dominates the entire glycerolipid metabolic flux. Phosphatidylcholines 54-56 phospholipid N-methyltransferase Arabidopsis thaliana 17-21 35574050-2 2023 Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles (NPs) loaded with plasmid DNA (pDNA) encoding transforming growth factor-beta 1 (TGF-beta1) to engineer MSCs for enhanced OA therapy via cartilage regeneration. Phosphatidylcholines 44-63 transforming growth factor, beta 1 Mus musculus 168-177 35474485-7 2022 Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 104-123 skull morphology 20 Mus musculus 39-42 35474485-7 2022 Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 125-127 skull morphology 20 Mus musculus 39-42 35460694-7 2022 Furthermore, miR-141/200c deficiency normalizes ethanol-mediated impairment of TG secretion, which can be attributed to the restored levels of HNF1B and MTTP, as well as phosphatidylcholine abundance. Phosphatidylcholines 170-189 microRNA 141 Mus musculus 13-25 35497501-4 2022 found that the fluorescently tagged C2 domain of phospholipase A2 binds to membrane phosphatidylcholine and thus labels vesicle membrane, allowing for super-resolution and electron microscopic visualization of vesicle trafficking. Phosphatidylcholines 84-103 phospholipase A2 group IB Homo sapiens 49-65 35452693-8 2022 Mechanistically, loss of Vmp1 led to decreased hepatic levels of phosphatidylcholine and phosphatidylethanolamine as well as the changes of phospholipid composition. Phosphatidylcholines 65-84 vacuole membrane protein 1 Mus musculus 25-29 35411667-11 2022 HSD17B13 perturbs plasma phosphatidylcholines and triglycerides. Phosphatidylcholines 25-45 hydroxysteroid 17-beta dehydrogenase 13 Homo sapiens 0-8 35343224-6 2022 Plasma phosphatidylcholines increased by lipidomics after SCD1 knockout in goats. Phosphatidylcholines 7-27 stearoyl-CoA desaturase Capra hircus 58-62 35019930-5 2022 Based on the strong "N-P" tetravalent electrostatic interaction between MCP and phosphatidyl choline on the erythrocyte membranes, MCP-PEG-FA can be modified on the erythrocyte membrane encapsulated doxorubicin (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) nanosystem to form a tumor-targeting erythrocyte membrane nanosystem (FA-RBC@PLGA-DOX). Phosphatidylcholines 80-100 CD46 molecule Homo sapiens 72-75 35007755-1 2022 Cytidine triphosphate:phosphocholine cytidylyltransferase-alpha (CTalpha) is the rate limiting enzyme in the pathway for de novo phosphatidylcholine (PC) synthesis. Phosphatidylcholines 129-148 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 65-72 35007755-1 2022 Cytidine triphosphate:phosphocholine cytidylyltransferase-alpha (CTalpha) is the rate limiting enzyme in the pathway for de novo phosphatidylcholine (PC) synthesis. Phosphatidylcholines 150-152 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 65-72 35330412-8 2022 Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD. Phosphatidylcholines 140-160 inturned planar cell polarity protein Homo sapiens 85-89 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 phospholipase D1 Homo sapiens 42-46 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 phospholipase D2 Homo sapiens 51-55 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 phospholipase D1 Homo sapiens 42-46 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 phospholipase D2 Homo sapiens 51-55 35362519-2 2022 In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth. Phosphatidylcholines 117-119 polyol/monosaccharide transporter 1 Arabidopsis thaliana 70-74 35362519-2 2022 In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth. Phosphatidylcholines 117-119 polyol/monosaccharide transporter 2 Arabidopsis thaliana 76-80 35362519-5 2022 Here, we show that PLMT is ubiquitously expressed in different organs and localized at the endoplasmic reticulum, where PC is produced. Phosphatidylcholines 120-122 phospholipid N-methyltransferase Arabidopsis thaliana 19-23 35362519-6 2022 Overexpression of PLMT in planta increased the content of phospholipids including PC and affected vegetative but not reproductive growth. Phosphatidylcholines 82-84 phospholipid N-methyltransferase Arabidopsis thaliana 18-22 35362519-9 2022 We conclude that PLMT might be a functional enzyme in PC biosynthesis and play an organ-specific role in developing seeds, where rapid accumulation of triacylglycerol dominates the entire glycerolipid metabolic flux. Phosphatidylcholines 54-56 phospholipid N-methyltransferase Arabidopsis thaliana 17-21 35322809-3 2022 Using Chkb knockout mice, we reveal that at no stage of the disease is phosphatidylcholine level significantly altered. Phosphatidylcholines 71-90 choline kinase beta Mus musculus 6-10 35330412-8 2022 Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD. Phosphatidylcholines 140-160 FAT atypical cadherin 1 Homo sapiens 91-95 35330412-8 2022 Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD. Phosphatidylcholines 140-160 contactin 6 Homo sapiens 97-102 35330412-8 2022 Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD. Phosphatidylcholines 140-160 transmembrane 9 superfamily member 2 Homo sapiens 108-114 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidylcholines 76-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidylcholines 76-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 35151687-1 2022 The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC). Phosphatidylcholines 129-148 choline kinase beta Mus musculus 4-8 35151687-1 2022 The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC). Phosphatidylcholines 129-148 choline kinase beta Mus musculus 22-41 35131264-0 2022 LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling. Phosphatidylcholines 77-96 lysophosphatidylglycerol acyltransferase 1 Mus musculus 0-6 35150739-6 2022 A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant phospholipid levels due to reductions in the most abundant surfactants, phosphatidylcholine containing di-palmitic acid and phosphatidylcholine species containing the omega-3 fatty acid docosahexaenoic acid. Phosphatidylcholines 201-220 major facilitator superfamily domain containing 2A Mus musculus 61-67 35150739-6 2022 A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant phospholipid levels due to reductions in the most abundant surfactants, phosphatidylcholine containing di-palmitic acid and phosphatidylcholine species containing the omega-3 fatty acid docosahexaenoic acid. Phosphatidylcholines 253-272 major facilitator superfamily domain containing 2A Mus musculus 61-67 35150739-8 2022 Mechanistically, direct tracheal instillation of fluorescent LPC and PC probes indicated that Mfsd2a mediates the uptake of LPC generated by pulmonary phospholipase activity in the alveolar space. Phosphatidylcholines 69-71 major facilitator superfamily domain containing 2A Mus musculus 94-100 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Phosphatidylcholines 193-212 lysophosphatidylglycerol acyltransferase 1 Mus musculus 25-67 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Phosphatidylcholines 193-212 lysophosphatidylglycerol acyltransferase 1 Homo sapiens 69-75 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Phosphatidylcholines 214-216 lysophosphatidylglycerol acyltransferase 1 Mus musculus 25-67 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Phosphatidylcholines 214-216 lysophosphatidylglycerol acyltransferase 1 Homo sapiens 69-75 35151687-1 2022 The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC). Phosphatidylcholines 150-152 choline kinase beta Mus musculus 4-8 35151687-1 2022 The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC). Phosphatidylcholines 150-152 choline kinase beta Mus musculus 22-41 35163842-7 2022 omega-3 fatty acids (e.g., docosahexaenoic acid) appear to be less prevalent in obese patient RBCs, and this is the case for both the global fatty acid distribution and for the individual major lipids in the membrane phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS). Phosphatidylcholines 217-236 pyruvate carboxylase Homo sapiens 238-240 35203270-1 2022 ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 35233071-2 2022 TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT). Phosphatidylcholines 266-285 glycerol-3-phosphate acyltransferase, chloroplastic Brassica napus 82-118 35233071-2 2022 TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT). Phosphatidylcholines 266-285 glycerol-3-phosphate acyltransferase, chloroplastic Brassica napus 120-124 35233071-2 2022 TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT). Phosphatidylcholines 287-289 glycerol-3-phosphate acyltransferase, chloroplastic Brassica napus 82-118 35233071-2 2022 TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT). Phosphatidylcholines 287-289 glycerol-3-phosphate acyltransferase, chloroplastic Brassica napus 120-124 35425434-2 2022 In this study, an attempt has been made to study the interaction involving phosphatidylcholine vesicles (PHOS VES, as model cell membrane) and four different carbon quantum dots bearing different functional groups (-COOH, -NH2, -OH, and protein bovine serum albumin coated) using various tools such as PL behavior, surface charge on vesicles, QCM, ITC, TEM, LSV, and FTIR. Phosphatidylcholines 75-94 albumin Homo sapiens 252-265 35187037-2 2022 Phosphatidylcholine (PC), a form of choline mostly found in eggs, has been shown to beneficially modulate T-cell responses during the lactation period by increasing the production of IL-2. Phosphatidylcholines 0-19 interleukin 2 Rattus norvegicus 183-187 35187037-2 2022 Phosphatidylcholine (PC), a form of choline mostly found in eggs, has been shown to beneficially modulate T-cell responses during the lactation period by increasing the production of IL-2. Phosphatidylcholines 21-23 interleukin 2 Rattus norvegicus 183-187 2513324-6 1989 Inhibitors of protein kinase C prevented the stimulated recycling of phosphatidylcholine, and the simultaneous induction of platelet-activating factor synthesis, by inhibiting phospholipase A2 activation. Phosphatidylcholines 69-88 phospholipase A2 group IB Homo sapiens 176-192 35185169-4 2022 Moreover, Redundancy analysis (RDA) was used to study the relationship between fatty acids, Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), peroxide value (POV) in Egg Yolk Gel. Phosphatidylcholines 92-111 pyruvate carboxylase Homo sapiens 113-115 35203427-5 2022 A sandwich ELISA detecting oxidized phosphatidylcholine in association with apolipoprotein B-100 (oxPL/apoB) was applied to measure oxidized phospholipids in circulation. Phosphatidylcholines 36-55 apolipoprotein B Homo sapiens 76-96 35203427-5 2022 A sandwich ELISA detecting oxidized phosphatidylcholine in association with apolipoprotein B-100 (oxPL/apoB) was applied to measure oxidized phospholipids in circulation. Phosphatidylcholines 36-55 apolipoprotein B Homo sapiens 103-107 35503176-3 2022 SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. Phosphatidylcholines 22-41 sphingomyelin synthase 1 Homo sapiens 0-4 35503176-3 2022 SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. Phosphatidylcholines 43-45 sphingomyelin synthase 1 Homo sapiens 0-4 35367966-0 2022 An Association Between Saturated Fatty Acid-Containing Phosphatidylcholine in Cerebrospinal Fluid with Tau Phosphorylation. Phosphatidylcholines 55-74 microtubule associated protein tau Homo sapiens 103-106 35048323-0 2022 D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes. Phosphatidylcholines 19-38 solute carrier family 2 member 4 Homo sapiens 114-119 35048323-5 2022 Here, we show that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4. Phosphatidylcholines 19-38 insulin Homo sapiens 100-107 35048323-5 2022 Here, we show that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4. Phosphatidylcholines 19-38 solute carrier family 2 member 4 Homo sapiens 135-140 35071223-3 2021 In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3. Phosphatidylcholines 132-134 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 39-43 35071223-3 2021 In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3. Phosphatidylcholines 132-134 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 165-169 35071223-5 2021 The blockage of PC production is well known to cause endoplasmic reticulum (ER) stress and activate the ER-stress sensor, Ire1, to induce unfolded protein response (UPR). Phosphatidylcholines 16-18 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 122-126 35503176-4 2022 SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions. Phosphatidylcholines 103-105 spermine synthase Homo sapiens 0-3 35240344-8 2022 Mechanistically, protection from hepatic inflammation and fibrosis by constitutive mTORC1 occurred via promotion of the phosphatidylcholine synthesizing enzyme, CCTalpha, and enhanced very low-density lipoprotein-triglyceride export. Phosphatidylcholines 120-139 CREB regulated transcription coactivator 1 Mus musculus 83-89 35240344-8 2022 Mechanistically, protection from hepatic inflammation and fibrosis by constitutive mTORC1 occurred via promotion of the phosphatidylcholine synthesizing enzyme, CCTalpha, and enhanced very low-density lipoprotein-triglyceride export. Phosphatidylcholines 120-139 t-complex protein 1 Mus musculus 161-169 35367966-10 2022 We propose mechanisms by which saturated PC may promote tau hyperphosphorylation. Phosphatidylcholines 41-43 microtubule associated protein tau Homo sapiens 56-59 2558733-1 1989 It is shown that good estimates of the activity of cholesterol in phosphatidylcholine-cholesterol mixed model membranes are obtained by examining the orientational order parameter S of cholestane spin probe (CSL) that is obtained from electron spin resonance by spectral simulation. Phosphatidylcholines 66-85 chorionic somatomammotropin hormone like 1 Homo sapiens 208-211 2512985-9 1989 These values are at least 10-fold higher than the ratio of 1-alkyl versus 1-acyl species in the cellular phosphatidylcholine precursor for PAF. Phosphatidylcholines 105-124 PCNA clamp associated factor Homo sapiens 139-142 2690829-2 1989 Phorbol 12-myristate 13-acetate (PMA), bombesin, platelet-derived growth factor (PDGF) and vasopressin rapidly stimulated PtdCho hydrolysis, diacylglycerol (DAG) production, and PtdCho synthesis. Phosphatidylcholines 122-128 peroneal muscular atrophy Mus musculus 0-37 2690829-2 1989 Phorbol 12-myristate 13-acetate (PMA), bombesin, platelet-derived growth factor (PDGF) and vasopressin rapidly stimulated PtdCho hydrolysis, diacylglycerol (DAG) production, and PtdCho synthesis. Phosphatidylcholines 178-184 peroneal muscular atrophy Mus musculus 0-37 2480893-6 1989 Specific activities tested by the capacity to hydrolyze phosphatidylcholines at pH 8.5 decreased as follows: Pa3 greater than Pa5 greater than Pa4 greater than Pa1 greater than Pa2. Phosphatidylcholines 56-76 Paxip1-associated glutamate-rich protein 1 Rattus norvegicus 160-163 2621418-3 1989 The relative contribution of various PC species towards LCAT reaction in ABL plasma was significantly different from that found in normal plasma. Phosphatidylcholines 37-39 lecithin-cholesterol acyltransferase Homo sapiens 56-60 2516855-6 1989 The binding equilibrium of apo A-I as to DPPC vesicles at low protein concentrations, as studied by hydrophobic labeling of the bilayer-penetrating segment, is reached within about 1 h, while the formation of micellar complexes at high protein concentrations takes about 24 h at 42 degrees C. Time-dependent labeling studies involving photoreactive phosphatidylcholine (PC) with high apo A-I concentrations suggested an initial interaction with the head group region of the bilayer followed by interaction with the tail ends of the acyl chains of the lipid. Phosphatidylcholines 349-368 apolipoprotein A1 Homo sapiens 27-34 2516855-6 1989 The binding equilibrium of apo A-I as to DPPC vesicles at low protein concentrations, as studied by hydrophobic labeling of the bilayer-penetrating segment, is reached within about 1 h, while the formation of micellar complexes at high protein concentrations takes about 24 h at 42 degrees C. Time-dependent labeling studies involving photoreactive phosphatidylcholine (PC) with high apo A-I concentrations suggested an initial interaction with the head group region of the bilayer followed by interaction with the tail ends of the acyl chains of the lipid. Phosphatidylcholines 43-45 apolipoprotein A1 Homo sapiens 27-34 2793844-0 1989 Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 2624682-2 1989 Some of these regions have been identified by reassembly of the total tryptic peptides of apo B-100 with bovine brain sphingomyelin, 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) and dimyristoylphosphatidylcholine (DPMC). Phosphatidylcholines 175-179 apolipoprotein B Bos taurus 90-99 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 167-186 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 0-4 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 167-186 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 9-13 2818589-0 1989 Interleukin 3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line. Phosphatidylcholines 25-44 interleukin 3 Mus musculus 0-13 2558407-5 1989 However, a clear inhibitory effect is seen when the enzyme is "reconstituted" with sonicated phosphatidylcholine, suggesting that the inhibition of the enzymatic activity is caused by perturbation of the environment of COX in the mitochondrial membrane. Phosphatidylcholines 93-112 cytochrome c oxidase subunit 8A Homo sapiens 219-222 2597670-2 1989 Both natural and synthetic SP-B and SP-C markedly stimulated phosphatidylcholine transfer to alveolar Type II cells and Chinese hamster lung fibroblasts in a dose- and time-dependent fashion. Phosphatidylcholines 61-80 surfactant protein B Bos taurus 27-31 2597670-2 1989 Both natural and synthetic SP-B and SP-C markedly stimulated phosphatidylcholine transfer to alveolar Type II cells and Chinese hamster lung fibroblasts in a dose- and time-dependent fashion. Phosphatidylcholines 61-80 surfactant protein C Bos taurus 36-40 2818589-3 1989 Treatment of these cells with interleukin 3 rapidly stimulated both the release of water-soluble choline metabolites and the resynthesis of phosphatidylcholine. Phosphatidylcholines 140-159 interleukin 3 Mus musculus 30-43 2818589-4 1989 Therefore, a phosphatidylcholine cycle may operate as part of the signal transduction pathway in cells responding to interleukin 3. Phosphatidylcholines 13-32 interleukin 3 Mus musculus 117-130 2811608-3 1989 This depression of fusion appears to be caused by a reduction in the amount of irreversibly bound alpha-lactalbumin to vesicles containing phosphatidylcholine. Phosphatidylcholines 139-158 lactalbumin alpha Homo sapiens 98-115 2480186-3 1989 The apposition of membranes rapidly induced by myelin basic protein is enhanced by sulfatide but reduced by galactocerebroside compared to vesicles of egg phosphatidylcholine alone. Phosphatidylcholines 155-174 myelin basic protein Homo sapiens 47-67 2480186-5 1989 Our results support an important modulation by sulfatide and galactocerebroside on the interactions among membranes induced by myelin basic protein, depending on the relative proportions of the glycosphingolipids and phosphatidylcholine. Phosphatidylcholines 217-236 myelin basic protein Homo sapiens 127-147 2511018-3 1989 The patient"s LpL purified from the PHP by heparin-Sepharose and phenyl-Sepharose chromatographies hydrolysed tributryrin, but not triolein emulsified with Triton X-100 and phosphatidylcholine (PC), or in chylomicrons, whereas normal LpL hydrolysed these substrates. Phosphatidylcholines 173-192 lipoprotein lipase Homo sapiens 14-17 2511018-3 1989 The patient"s LpL purified from the PHP by heparin-Sepharose and phenyl-Sepharose chromatographies hydrolysed tributryrin, but not triolein emulsified with Triton X-100 and phosphatidylcholine (PC), or in chylomicrons, whereas normal LpL hydrolysed these substrates. Phosphatidylcholines 194-196 lipoprotein lipase Homo sapiens 14-17 2811608-0 1989 Effect of phosphatidylcholine on the alpha-lactalbumin-induced fusion of vesicles. Phosphatidylcholines 10-29 lactalbumin alpha Homo sapiens 37-54 2811608-1 1989 Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin. Phosphatidylcholines 216-235 lactalbumin alpha Homo sapiens 20-37 2590161-5 1989 ACAT activity of deoxycholate-solubilized homogenates reconstituted into phosphatidylcholine vesicles was independent of the presence of serum lipoproteins during culture and dependent on cholesterol present in the vesicles for all cell types. Phosphatidylcholines 73-92 sterol O-acyltransferase 1 Homo sapiens 0-4 2554971-5 1989 Spin-labeled monogalactosyldiacylglycerol exhibits very little preferential interaction over phosphatidylchline, which suggests that part of the role of monogalactosyldiacylglycerol in thylakoid membranes is structural, as is the case for phosphatidylcholine in mammalian membranes. Phosphatidylcholines 239-258 spindlin 1 Homo sapiens 0-4 2617942-4 1989 The diet of coast Chuchkchee land inhabitants, involving the higher level of unsaturated fatty acids n-3, resulted in the higher ratio between HDL cholesterol and apoA-I, in the higher part of unsaturated fatty acids n-3 in blood plasma lipids (phospholipids and cholesterol esters) and erythrocytes; it led to a relative increase of sphingomyelin and phosphatidyl-ethanolamine and to a decrease of phosphatidylcholine in HDL subfractions. Phosphatidylcholines 399-418 apolipoprotein A1 Homo sapiens 163-169 2549032-17 1989 These data suggest that CCK stimulates both phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis; the latter may contribute to the sustained generation of DAG and hence the maintained activation of protein kinase C. Phosphatidylcholines 86-105 cholecystokinin Rattus norvegicus 24-27 2806192-2 1989 The contribution of these phospholipids to the incorporation of 3H-labeled phosphatidylcholine (PC) liposomes into rat alveolar type II cells stimulated by SP-C was examined. Phosphatidylcholines 96-98 surfactant protein C Rattus norvegicus 156-160 2815072-9 1989 The % composition of palmitic acid in PC molecule, which is the main component of saturated fatty acid of lung surfactant, was significantly higher in hEGF group than in sham operated group (p less than 0.05). Phosphatidylcholines 38-40 epidermal growth factor Homo sapiens 151-155 2554971-6 1989 Spin-labeled phosphatidylglycerol shows a preferential interaction over the corresponding monogalactosyldiacylglycerol and phosphatidylcholine analogues, in contrast to the common behavior of this lipid in mammalian systems. Phosphatidylcholines 123-142 spindlin 1 Homo sapiens 0-4 2806192-7 1989 Thus, the ability of SP-C to stimulate liposomal PC uptake by rat type II cells could be accounted for by its phospholipid composition. Phosphatidylcholines 49-51 surfactant protein C Rattus norvegicus 21-25 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 156-175 apolipoprotein A2 Homo sapiens 0-7 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 156-175 apolipoprotein A2 Homo sapiens 102-109 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 156-175 apolipoprotein A1 Homo sapiens 102-108 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 177-179 apolipoprotein A2 Homo sapiens 0-7 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 177-179 apolipoprotein A2 Homo sapiens 102-109 2503030-3 1989 ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Phosphatidylcholines 177-179 apolipoprotein A1 Homo sapiens 102-108 2545786-4 1989 When [3H] AA-labeled neutrophils were exposed to PAF, the enhanced release of AA was observed with a concomitant decrease of radioactivity in phosphatidylinositol and phosphatidylcholine fractions. Phosphatidylcholines 167-186 PCNA clamp associated factor Homo sapiens 49-52 2546942-7 1989 From the dependence of the energy transfer upon the acceptor density and assuming kappa 2 = 2/3, the distance of closest approach between a dye in the active site of the thrombin-thrombomodulin complex and a dye at the membrane surface was determined to average 66 A (65 +/- 3 A for phosphatidylcholine vesicles without and 67 +/- 5 A for those with 20% phosphatidylserine). Phosphatidylcholines 283-302 coagulation factor II, thrombin Homo sapiens 170-178 2548919-0 1989 Spin label and microcalorimetric studies of the interaction of DNA with unilamellar phosphatidylcholine liposomes. Phosphatidylcholines 84-103 spindlin 1 like Gallus gallus 0-4 2742867-0 1989 18O isotope exchange experiments on phospholipase A2 determined by 13C-NMR: monomeric phosphatidylcholine and micellar phosphatidylethanolamine substrates. Phosphatidylcholines 86-105 phospholipase A2 group IB Homo sapiens 36-52 2545711-6 1989 The purified neutral sphingomyelinase (N-SMase) had low levels of phospholipase A1 and A2 activity when phosphatidylcholine was used as a substrate and detergents were included in the assay mixture. Phosphatidylcholines 104-123 sphingomyelin phosphodiesterase 2 Homo sapiens 13-37 2545711-6 1989 The purified neutral sphingomyelinase (N-SMase) had low levels of phospholipase A1 and A2 activity when phosphatidylcholine was used as a substrate and detergents were included in the assay mixture. Phosphatidylcholines 104-123 sphingomyelin phosphodiesterase 2 Homo sapiens 39-46 2753160-4 1989 These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 2753160-4 1989 These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 2570849-4 1989 Phosphatidic acid (PA)-specific and phosphatidylcholine (PC)-specific PLA2 activities from rat cerebral cortical synaptosomes were stimulated in incubation medium containing high concentrations of K+ or calcium ionophore A23187. Phosphatidylcholines 36-55 phospholipase A2 group IB Rattus norvegicus 70-74 2751648-1 1989 The effect of tricyclodecan-9-yl-xanthogenate on the phorbolester TPA induced changes in phosphatidylcholine metabolism was investigated. Phosphatidylcholines 89-108 plasminogen activator, tissue type Homo sapiens 66-69 2751648-3 1989 The precursor molecule [3H] choline was incorporated into phosphatidylcholine after pulse labeling in TPA/D609-treated cells. Phosphatidylcholines 58-77 plasminogen activator, tissue type Homo sapiens 102-105 2774696-1 1989 The hydrolysis of radiolabelled Escherichia coli phospholipids, and micellar dispersions of phosphatidylethanolamine and phosphatidylcholine, were used to characterise the phospholipase A2 activity in synovial fluid from patients with rheumatoid arthritis. Phosphatidylcholines 121-140 phospholipase A2 group IB Homo sapiens 172-188 2501296-1 1989 Evidence for involvement of protein kinase C. Previous studies demonstrated that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells (Kolesnick, R. N. (1987) J. Biol. Phosphatidylcholines 147-166 thyrotropin releasing hormone Rattus norvegicus 100-129 2501296-1 1989 Evidence for involvement of protein kinase C. Previous studies demonstrated that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells (Kolesnick, R. N. (1987) J. Biol. Phosphatidylcholines 147-166 thyrotropin releasing hormone Rattus norvegicus 131-134 2501296-9 1989 This correlated closely with TRH-induced phosphatidylcholine and phosphatidylinositol synthesis; EC50 congruent to 2 x 10(-10) and 1.5 x 10(-10) M TRH, respectively. Phosphatidylcholines 41-60 thyrotropin releasing hormone Rattus norvegicus 29-32 2501296-9 1989 This correlated closely with TRH-induced phosphatidylcholine and phosphatidylinositol synthesis; EC50 congruent to 2 x 10(-10) and 1.5 x 10(-10) M TRH, respectively. Phosphatidylcholines 41-60 thyrotropin releasing hormone Rattus norvegicus 147-150 2501296-13 1989 Like the effect of TRH on phosphatidylcholine synthesis, TRH-induced sphingomyelin synthesis was abolished in cells "down-modulated" for protein kinase C. In contrast, TRH-induced phosphatidylinositol synthesis still occurred in these cells. Phosphatidylcholines 26-45 thyrotropin releasing hormone Rattus norvegicus 19-22 2570849-4 1989 Phosphatidic acid (PA)-specific and phosphatidylcholine (PC)-specific PLA2 activities from rat cerebral cortical synaptosomes were stimulated in incubation medium containing high concentrations of K+ or calcium ionophore A23187. Phosphatidylcholines 57-59 phospholipase A2 group IB Rattus norvegicus 70-74 2730887-2 1989 Therefore, we studied the effects of CCl4 on the synthesis of surfactant phosphatidylcholines (PCs) in rat alveolar type II cells in vitro. Phosphatidylcholines 73-93 C-C motif chemokine ligand 4 Rattus norvegicus 37-41 2487757-4 1989 Hydrolysis of PC and PE with phospholipase A2 (EC 3.1.1.4) released about 50% of the total radioactivity as lipid moieties corresponding to fatty acids. Phosphatidylcholines 14-16 phospholipase A2 group IB Rattus norvegicus 29-45 2730887-7 1989 All of these data suggest that there is a common site(s) at which CCl4 inhibits PC synthesis and that the inhibition occurs early in the biosynthetic pathway. Phosphatidylcholines 80-82 C-C motif chemokine ligand 4 Rattus norvegicus 66-70 2730887-9 1989 Exposure of alveolar type II cells to CCl4 does cause a rapid and dramatic loss in cellular ATP, a cofactor required by some enzymes involved in PC synthesis. Phosphatidylcholines 145-147 C-C motif chemokine ligand 4 Rattus norvegicus 38-42 2730888-7 1989 These results show that lecithin-cholesterol acyltransferase has significant effects on the molecular species composition of plasma PC and the deficiency of the enzyme results in accumulation of certain PC species normally used by the enzyme, as well as in abnormal distribution of these species among the lipoproteins. Phosphatidylcholines 132-134 lecithin-cholesterol acyltransferase Homo sapiens 24-60 2730888-7 1989 These results show that lecithin-cholesterol acyltransferase has significant effects on the molecular species composition of plasma PC and the deficiency of the enzyme results in accumulation of certain PC species normally used by the enzyme, as well as in abnormal distribution of these species among the lipoproteins. Phosphatidylcholines 203-205 lecithin-cholesterol acyltransferase Homo sapiens 24-60 2540712-6 1989 The hydrophobic labeling studies with photoreactive phosphatidylcholine in the bilayer show that segments of both cytochrome c and apocytochrome c go deep into the bilayer. Phosphatidylcholines 52-71 cytochrome c, somatic Homo sapiens 114-126 2715209-8 1989 The interference of phosphatidylcholine and/or its metabolite(s) with the cerebral enzyme antioxidant system shows a characteristic specificity as regards both the time of onset and the enzyme activities involved, namely, SOD and glutathione reductase. Phosphatidylcholines 20-39 glutathione-disulfide reductase Rattus norvegicus 230-251 2722792-2 1989 Phosphatidylcholine synthesized in situ in this manner is an acyl donor for retinyl ester synthesis, demonstrating the existence of lecithin:retinol acyltransferase. Phosphatidylcholines 0-19 lecithin retinol acyltransferase Homo sapiens 132-164 2670666-2 1989 We have demonstrated that the opi3 mutations cause a deficiency in the two terminal phospholipid N-methyltransferase (PLMT) activities required for the de novo synthesis of PC (phosphatidylcholine). Phosphatidylcholines 173-175 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 30-34 2670666-2 1989 We have demonstrated that the opi3 mutations cause a deficiency in the two terminal phospholipid N-methyltransferase (PLMT) activities required for the de novo synthesis of PC (phosphatidylcholine). Phosphatidylcholines 177-196 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 30-34 2670666-13 1989 We have used the opi3 strains to demonstrate that synthesis of either PC or PD (phosphatidyldimethylethanolamine) will restore normal regulation of the INO1 gene. Phosphatidylcholines 70-72 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 17-21 2670666-13 1989 We have used the opi3 strains to demonstrate that synthesis of either PC or PD (phosphatidyldimethylethanolamine) will restore normal regulation of the INO1 gene. Phosphatidylcholines 70-72 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 152-156 2542284-2 1989 When either the solubilized Na+-Ca2+ exchanger or the Na+,K+-ATPase is reconstituted into phosphatidylcholine (PC):phosphatidylserine (30:50 by weight) vesicles, high cholesterol levels (20% by weight) are required for activity to be expressed. Phosphatidylcholines 90-109 solute carrier family 8 member A1 Homo sapiens 28-46 2542284-2 1989 When either the solubilized Na+-Ca2+ exchanger or the Na+,K+-ATPase is reconstituted into phosphatidylcholine (PC):phosphatidylserine (30:50 by weight) vesicles, high cholesterol levels (20% by weight) are required for activity to be expressed. Phosphatidylcholines 111-113 solute carrier family 8 member A1 Homo sapiens 28-46 2541791-13 1989 The discrepancies in the influence of PC on G-6-Pase were interpreted by assuming that the enzyme was a two-component system, a surface-located substrate transporter unit and a membrane integral catalytic phosphohydrolase unit. Phosphatidylcholines 38-40 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 44-52 2524476-3 1989 At 1.2 mM Ca2+, 0.50 M ionic strength, pH 7.4, 25 degrees C, fluorescein-labeled PAP-I bound to phospholipid vesicles containing 80% phosphatidylcholine, 20% phosphatidylserine with a Kd of 1.2 +/- 0.2 nM (mean +/- S.D.). Phosphatidylcholines 133-152 annexin A5 Homo sapiens 81-86 2494162-0 1989 An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma. Phosphatidylcholines 26-45 phospholipase A2 group VII Homo sapiens 69-111 2736780-1 1989 The accumulation of phosphatidylcholine (PC) in cultured fibroblasts of mucolipidosis IV (MLIV) patients was studied by subcellular fractionation on percoll gradients. Phosphatidylcholines 20-39 mucolipin TRP cation channel 1 Homo sapiens 90-94 2736780-2 1989 Labelled PC accumulated in secondary lysosomes of the MLIV cells in significantly higher rates when compared to normal controls incubated with the precursors [32P]phosphate or [14C]choline. Phosphatidylcholines 9-11 mucolipin TRP cation channel 1 Homo sapiens 54-58 2736780-6 1989 In these experiments increased labelled PC in MLIV was also noted in endosomes, which are involved in the uptake process of PC enroute to the lysosomes. Phosphatidylcholines 40-42 mucolipin TRP cation channel 1 Homo sapiens 46-50 2736780-6 1989 In these experiments increased labelled PC in MLIV was also noted in endosomes, which are involved in the uptake process of PC enroute to the lysosomes. Phosphatidylcholines 124-126 mucolipin TRP cation channel 1 Homo sapiens 46-50 2775183-8 1989 Thus phosphatidylcholine synthesis via reacylation of lysophosphatidylcholine, via the CDP-choline pathway or via methylation of phosphatidylethanolamine, will satisfy the requirements for secretion of very-low-density lipoprotein from hepatocytes. Phosphatidylcholines 5-24 cut-like homeobox 1 Rattus norvegicus 87-90 2525936-0 1989 Nuclear magnetic resonance spectroscopic studies of interaction of bis-GMA analogues with phosphatidylcholine liposomes as a model for biomembranes. Phosphatidylcholines 90-109 myelin associated glycoprotein Homo sapiens 71-74 2496984-3 1989 The hypotheses proposed in the literature for the role of phospholipids in the reconstituted cytochrome P-450 system, mainly based on the comparison of systems without phospholipid and with Lau2GroPCho, were either validated or shown to be unlikely when tested by comparing reconstituted systems with different phosphatidylcholines. Phosphatidylcholines 311-331 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-109 2496984-7 1989 From these observations it is concluded that the higher activity of the Lau2GroPCho system compared with the Ste2GroPCho system or with a system without additional phosphatidylcholine may at least in part be caused by a difference in the conformation of the cytochrome P-450 molecules in these systems. Phosphatidylcholines 164-183 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 258-274 2496984-8 1989 Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450. Phosphatidylcholines 43-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-216 2496984-8 1989 Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450. Phosphatidylcholines 43-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 310-326 2749908-0 1989 [Complexing of bovine serum albumin with phosphatidyl choline liposomes]. Phosphatidylcholines 41-61 albumin Homo sapiens 22-35 2749908-1 1989 Thermodynamic parameters of the bovine serum albumin interaction with phosphatidyl choline liposomes have been determined. Phosphatidylcholines 70-90 albumin Homo sapiens 39-52 2539188-1 1989 Neutral phospholipase A2 activity, which hydrolyzed phosphatidylcholine and phosphatidylethanolamine with the same efficiency, was identified in the nuclear matrix prepared from purified nuclei of rat ascites hepatoma cells (AH 7974). Phosphatidylcholines 52-71 phospholipase A2 group IB Rattus norvegicus 8-24 2736780-5 1989 The retention of PC in lysosomes of MLIV could also be demonstrated following incubation of cultured fibroblasts with the radioactive phospholipid itself. Phosphatidylcholines 17-19 mucolipin TRP cation channel 1 Homo sapiens 36-40 2722775-5 1989 Analysis of PDE:phosphatidylcholine product ratios indicates that the enzyme can conduct multiple methylations of enzyme-bound phospholipid. Phosphatidylcholines 16-35 aldehyde dehydrogenase 7 family member A1 Homo sapiens 12-15 2497105-7 1989 On the other hand, phosphatidylcholine vesicles containing either phosphatidylserine or phosphatidylinositol strongly interacted with synapsin I. Phosphatidylcholines 19-38 synapsin I Homo sapiens 134-144 2497105-10 1989 Photolabeling of synapsin I was performed with the phosphatidylcholine analogue 1-palmitoyl-2-[11-[4-[3-(trifluoromethyl)diazirinyl]phenyl] [2-3H]undecanoyl]-sn-glycero-3-phosphocholine; this compound generates a highly reactive carbene that selectively interacts with membrane-embedded domains of membrane proteins. Phosphatidylcholines 51-70 synapsin I Homo sapiens 17-27 2497106-3 1989 The binding of synapsin I was preserved when synaptic vesicles were solubilized and reconstituted in phosphatidylcholine. Phosphatidylcholines 101-120 synapsin I Homo sapiens 15-25 2713384-7 1989 Time-course studies showed that in the presence of an LCAT inhibitor there was considerable conversion of phosphatidylcholine to lysophosphatidylcholine in heparin-treated plasma, and that this activity was diminished by 1 M NaCl, but that no phospholipolysis was observed in control plasma. Phosphatidylcholines 106-125 lecithin cholesterol acyltransferase Rattus norvegicus 54-58 2494162-7 1989 We now have found that the purified PAF acetylhydrolase catalyzes the hydrolysis of the oxidized fragments of arachidonic acid from the sn-2 position of phosphatidylcholine. Phosphatidylcholines 153-172 phospholipase A2 group VII Homo sapiens 36-55 2705543-10 1989 The acetylhydrolase activity was different from phospholipase A2, since phosphatidylcholine was not a substrate for the enzyme. Phosphatidylcholines 72-91 phospholipase A2 group IB Homo sapiens 48-64 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. Phosphatidylcholines 111-130 phospholipase A2 group IB Homo sapiens 31-47 2470427-2 1989 In vesicles composed of phosphatidic acid and phosphatidylcholine, incubation with cytochrome c induced the reorganization of phospholipids into large phosphatidic acid-enriched domains with the exclusion of phosphatidylcholine. Phosphatidylcholines 46-65 cytochrome c, somatic Homo sapiens 83-95 2470427-2 1989 In vesicles composed of phosphatidic acid and phosphatidylcholine, incubation with cytochrome c induced the reorganization of phospholipids into large phosphatidic acid-enriched domains with the exclusion of phosphatidylcholine. Phosphatidylcholines 208-227 cytochrome c, somatic Homo sapiens 83-95 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. Phosphatidylcholines 111-130 phospholipase A2 group IIA Homo sapiens 48-52 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. Phosphatidylcholines 132-134 phospholipase A2 group IB Homo sapiens 31-47 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. Phosphatidylcholines 132-134 phospholipase A2 group IIA Homo sapiens 48-52 2646638-6 1989 Hydrolysis of phosphatidylinositol by phospholipase A2 appears to be the source of angiogenin-mobilized arachidonate; angiogenin-induced hydrolysis of phosphatidylcholine was not detected. Phosphatidylcholines 151-170 angiogenin Homo sapiens 118-128 2760017-1 1989 When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase. Phosphatidylcholines 132-151 apolipoprotein E Homo sapiens 11-27 2754332-6 1989 A rapid filtration binding assay demonstrated significant binding of cholesterol and phosphatidylcholine in vesicles to gallbladder mucin but only minimal binding of cholesterol and phosphatidylcholine in mixed micelles. Phosphatidylcholines 85-104 mucin 1, cell surface associated Bos taurus 132-137 2754332-7 1989 These data indicate that gallbladder mucin binds cholesterol and phosphatidylcholine in vesicles and accelerates the nucleation of cholesterol monohydrate crystals from these cholesterol-transporting particles in supersaturated model bile. Phosphatidylcholines 65-84 mucin 1, cell surface associated Bos taurus 37-42 2704040-2 1989 By measuring surface pressure at constant surface area, p68 was found to interact in a Ca2+ -dependent manner specifically with phosphatidylethanolamine, less so with phosphatidylserine and not at all with phosphatidylcholine. Phosphatidylcholines 206-225 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 56-59 2665826-4 1989 The insertion of LPS was probably accompanied by the expulsion of a small portion of phosphatidylcholine molecules from the outer monolayer of LDL into the aqueous medium and by an increase in the phosphatidylethanolamine concentration in LDL. Phosphatidylcholines 85-104 interferon regulatory factor 6 Homo sapiens 17-20 2723538-0 1989 Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase. Phosphatidylcholines 14-33 phospholipase A2 group VII Homo sapiens 70-112 2723538-2 1989 In this study, we have shown that this phospholipid hydrolysis is brought about by an LDL-associated phospholipase A2 that can hydrolyze oxidized but not intact LDL phosphatidylcholine. Phosphatidylcholines 165-184 phospholipase A2 group VII Homo sapiens 86-117 2760017-1 1989 When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase. Phosphatidylcholines 132-151 apolipoprotein E Homo sapiens 29-33 2466844-11 1989 However, when lipophilin was incorporated into phosphatidylcholine vesicles (50% w/w), small, optically clear suspensions of vesicles were formed. Phosphatidylcholines 47-66 proteolipid protein 1 Homo sapiens 14-24 2925651-3 1989 Similarly, phosphatidylcholine synthesis in permeable cells incubated in the presence of exogenous CDP-choline was similar to that of intact hepatocytes and at the expense of microsomal neutral lipid synthesis. Phosphatidylcholines 11-30 cut-like homeobox 1 Rattus norvegicus 99-102 2917151-0 1989 Co-ordinate control of CDP-choline and phosphatidylethanolamine methyltransferase pathways for phosphatidylcholine biosynthesis occurs in response to change in diet fat. Phosphatidylcholines 95-114 cut like homeobox 1 Homo sapiens 23-26 2917147-0 1989 Phosphatidylcholine and triacylglycerol hydrolysis in HDL as induced by hepatic lipase: modulation of the phospholipase activity by changes in the particle surface or in the lipid core. Phosphatidylcholines 0-19 lipase C, hepatic type Homo sapiens 72-86 2540823-1 1989 Ca2+ binding between lamellae of phosphatidylserine (PS) and phosphatidylcholine (PC) gives rise to a rigid phase of Ca(PS)2. Phosphatidylcholines 61-80 surfactant protein C Homo sapiens 82-84 2849934-1 1988 The ability of bradykinin to stimulate phosphodiesteratic cleavage of phosphatidylcholine (PC) was investigated in bovine pulmonary artery endothelial cells prelabeled with [3H]choline and [3H]myristic acid. Phosphatidylcholines 91-93 kininogen 1 Bos taurus 15-25 2927050-1 1989 A position-specifically labelled phosphatidylcholine is the substrate for the selective determination of Phospholipase A2 in serum, ascites and tissue samples. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 105-121 2523541-6 1989 Whereas photooxidized egg phosphatidylcholine liposomes underwent total LOOH loss when incubated with PLA2 and GSH/Gpx, no net loss was observed with photooxidized cholesterol/dimyristoyl-phosphatidylcholine liposomes. Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 102-106 2500989-4 1989 Phospholipase A2 is activated by a variety of physical and chemical agents (e.g. infection, trauma) that increase calcium concentrations in the cell; it releases arachidonic acid from phosphatidyl-choline and phosphatidyl-ethanolamine in particular. Phosphatidylcholines 184-204 phospholipase A2 group IB Homo sapiens 0-16 2702039-2 1989 TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio. Phosphatidylcholines 67-86 transforming growth factor beta 1 Homo sapiens 0-8 2702039-2 1989 TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio. Phosphatidylcholines 88-90 transforming growth factor beta 1 Homo sapiens 0-8 2702039-2 1989 TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio. Phosphatidylcholines 95-97 transforming growth factor beta 1 Homo sapiens 0-8 2495252-1 1989 Multilamellar liposomes of phosphatidylcholine and phosphatidylserine at a 7:3 molar ratio significantly inhibited activation of murine resident peritoneal macrophages by recombinant murine interferon-gamma for cytotoxicity against amastigotes of the protozoan parasite Leishmania major; other macrophage effector functions, such as particle phagocytosis or tumoricidal activity, were unaffected. Phosphatidylcholines 27-46 interferon gamma Mus musculus 190-206 2477617-1 1989 A method for measuring the activity of the red cell endogenous phospholipase A is suggested, consisting in red cell destruction, extraction of erythrocytic phospholipase, and detection of the enzymic activity by phosphatidylcholine hydrolysis in the organic phase from the degree of clarification of the lecithin emulsion. Phosphatidylcholines 212-231 phospholipase A and acyltransferase 1 Homo sapiens 63-78 2811473-1 1989 We have previously shown that interleukin-1 (IL-1) rapidly stimulates the hydrolysis of phosphatidylcholine in the human T lymphocyte cell line, Jurkat (Rosoff, et al., Cell 54: 73-81, 1988). Phosphatidylcholines 88-107 interleukin 1 alpha Homo sapiens 30-49 2916229-4 1989 Since erythrocytes from ruminant animals contain little or no phosphatidylcholine, perhaps the presence of phosphatidylcholine in the membrane is required for the hemolytic action of T-2 toxin. Phosphatidylcholines 107-126 solute carrier family 25 member 5 Homo sapiens 183-186 16347840-3 1989 The solid n-alkanes octadecane (C(18)) and hexatriacontane (C(36)) were encapsulated into phosphatidylcholine bilayers (liposomes). Phosphatidylcholines 90-109 Bardet-Biedl syndrome 9 Homo sapiens 32-37 2540142-9 1989 Interactions between the P1 and P2 pathways may explain the high potency of extracellular ATP as an agonist of PC exocytosis. Phosphatidylcholines 111-113 perforin 1 Rattus norvegicus 25-34 2922759-5 1989 In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner. Phosphatidylcholines 29-48 patatin like phospholipase domain containing 6 Gallus gallus 151-154 2922759-5 1989 In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner. Phosphatidylcholines 29-48 patatin like phospholipase domain containing 6 Gallus gallus 278-281 2912496-1 1989 The current study examined the effect of vasopressin on the secretion of phosphatidylcholine, the principal component of pulmonary surfactant, from adult rat alveolar type II pneumocytes in primary culture. Phosphatidylcholines 73-92 arginine vasopressin Rattus norvegicus 41-52 2912496-5 1989 The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9. Phosphatidylcholines 19-38 arginine vasopressin Rattus norvegicus 50-61 2912496-5 1989 The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9. Phosphatidylcholines 19-38 arginine vasopressin Rattus norvegicus 84-95 2912496-9 1989 When vasopressin and isoproterenol were added concomitantly, the effects on phosphatidylcholine secretion were additive. Phosphatidylcholines 76-95 arginine vasopressin Rattus norvegicus 5-16 2541798-0 1989 Synergistic effects in PR3+ transport mediated by ionophores across phosphatidylcholine vesicles. Phosphatidylcholines 68-87 proteinase 3 Homo sapiens 23-26 2541798-1 1989 Use of a fluorescent probe for the intravesicular pH shows that synergisms previously observed in Pr3+ transport across phosphatidylcholine vesicles are explained by an increase in the proton counter-transport. Phosphatidylcholines 120-139 proteinase 3 Homo sapiens 98-101 2647398-1 1989 Based on the cholinergic-deficiency hypothesis of tardive dyskinesia (TD), we administered cytidine diphosphoryl choline (CDP-Choline) (a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine), 500 mg twice a day orally, to four women and one man with TD for 2 to 8 weeks in a double-blind, placebo-controlled crossover trial. Phosphatidylcholines 203-222 cut like homeobox 1 Homo sapiens 122-125 2498670-2 1989 Both substances can be generated intracellularly by the action of phospholipase A2 on phosphatidylcholine. Phosphatidylcholines 86-105 phospholipase A2 group IB Homo sapiens 66-82 2849934-0 1988 Bradykinin stimulates phosphodiesteratic cleavage of phosphatidylcholine in cultured endothelial cells. Phosphatidylcholines 53-72 kininogen 1 Bos taurus 0-10 2849934-1 1988 The ability of bradykinin to stimulate phosphodiesteratic cleavage of phosphatidylcholine (PC) was investigated in bovine pulmonary artery endothelial cells prelabeled with [3H]choline and [3H]myristic acid. Phosphatidylcholines 70-89 kininogen 1 Bos taurus 15-25 2850176-3 1988 We found that its subcellular localization (mainly in microsomal and cytosolic fractions) was different from that of phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17), the enzyme of the alternative pathway for phosphatidylcholine synthesis. Phosphatidylcholines 219-238 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 117-161 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. Phosphatidylcholines 167-186 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. Phosphatidylcholines 167-186 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. Phosphatidylcholines 188-194 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. Phosphatidylcholines 188-194 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 3223955-10 1988 In the presence of endogenous substrates, the rates of PeMT-catalysed PtdCho formation within homogenates of rat mammary tissue were similar in tissue from lactating and non-lactating animals. Phosphatidylcholines 70-76 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 55-59 3196745-0 1988 Substrate specificity of human plasma lecithin-cholesterol acyltransferase towards molecular species of phosphatidylcholine in native plasma. Phosphatidylcholines 104-123 lecithin-cholesterol acyltransferase Homo sapiens 38-74 3196745-1 1988 The specificity of human plasma lecithin-cholesterol acyltransferase for molecular species of phosphatidylcholine (PC) was studied by determining the molecular species composition of whole plasma before and after incubation at 37 degrees C. Since the disappearance of PC under the conditions employed is entirely due to the activity of lecithin-cholesterol acyltransferase, its specificity can be determined from the decrease in the concentration of each species after the reaction. Phosphatidylcholines 94-113 lecithin-cholesterol acyltransferase Homo sapiens 32-68 3196745-1 1988 The specificity of human plasma lecithin-cholesterol acyltransferase for molecular species of phosphatidylcholine (PC) was studied by determining the molecular species composition of whole plasma before and after incubation at 37 degrees C. Since the disappearance of PC under the conditions employed is entirely due to the activity of lecithin-cholesterol acyltransferase, its specificity can be determined from the decrease in the concentration of each species after the reaction. Phosphatidylcholines 94-113 lecithin-cholesterol acyltransferase Homo sapiens 336-372 3196745-7 1988 These results indicate that in native plasma, lecithin-cholesterol acyltransferase prefers 16:0 greater than 18:1 greater than 18:0 at the 1-position and 18:2 greater than 18:1 greater than 22:6 greater than 20:4 at the 2-position of PC. Phosphatidylcholines 234-236 lecithin-cholesterol acyltransferase Homo sapiens 46-82 3202520-8 1988 We discovered that calcium and phosphatidylcholine both enhanced, but ATP inhibited, the 15-lipoxygenase activity of highly enriched enzyme. Phosphatidylcholines 31-50 arachidonate 15-lipoxygenase Homo sapiens 89-104 2846571-4 1988 Effects of vanadate on the function of a guanine nucleotide-binding protein were investigated in a reconstituted model system consisting of purified transducin subunits (T alpha, T beta gamma) and rhodopsin in phosphatidylcholine vesicles. Phosphatidylcholines 210-229 rhodopsin Homo sapiens 197-206 3244018-1 1988 A new method for reconstituting acyl coenzyme A: cholesterol acyltransferase (ACAT) activity from either Chinese hamster ovary (CHO) or human fibroblast cell extracts into cholesterol-phosphatidylcholine liposomes is described. Phosphatidylcholines 184-203 carboxylesterase 1 Homo sapiens 32-76 3244018-1 1988 A new method for reconstituting acyl coenzyme A: cholesterol acyltransferase (ACAT) activity from either Chinese hamster ovary (CHO) or human fibroblast cell extracts into cholesterol-phosphatidylcholine liposomes is described. Phosphatidylcholines 184-203 sterol O-acyltransferase 1 Cricetulus griseus 78-82 2851994-3 1988 In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w). Phosphatidylcholines 306-325 coagulation factor II, thrombin Homo sapiens 78-86 2851994-3 1988 In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w). Phosphatidylcholines 306-325 thrombomodulin Homo sapiens 172-186 3146971-3 1988 In studies of the effect on PA synthesis de novo, insulin stimulated [2-3H]glycerol incorporation into PA, DAG, PC/PE and total glycerolipids of BC3H-1 myocytes, regardless of whether insulin was added simultaneously with, or after 2 h or 3 or 10 days of prelabelling with, [2-3H]glycerol. Phosphatidylcholines 112-114 insulin Homo sapiens 50-57 3146971-10 1988 In addition to increases in [3H]glycerol labelling of PC/PE, insulin rapidly (within 30 s) increased PC/PE labelling by [3H]arachidonic acid, [3H]myristic acid, and [14C]choline. Phosphatidylcholines 54-56 insulin Homo sapiens 61-68 3191996-5 1988 In cells transformed with human or mouse A-raf carrying retroviruses TPA-stimulated PtdCho hydrolysis, but not CerPCho synthesis, suggesting independent regulation of these processes by the TPA-stimulated signal transduction system. Phosphatidylcholines 84-90 Araf proto-oncogene, serine/threonine kinase Mus musculus 41-46 3149286-1 1988 Apolipoprotein A-I was purified from human high density lipoprotein and complexed with polyunsaturated phosphatidylcholine (PC) in deoxycholate (Lipostabil); the bile salt was removed subsequently by dialysis. Phosphatidylcholines 124-126 apolipoprotein A1 Homo sapiens 0-18 3264481-2 1988 It was postulated that phospholipase A2 (PLA2) exposure would potentiate porcine pancreatic elastase (PPE)-induced epithelial solute permeability in a manner similar to that which was previously shown with lysophosphatidylcholine (lysoPC), a naturally occurring, membrane-perturbing agent that is formed principally through the hydrolysis of phosphatidylcholine by PLA2. Phosphatidylcholines 210-229 phospholipase A2 group IB Homo sapiens 41-45 2846391-2 1988 The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells. Phosphatidylcholines 46-65 cut like homeobox 1 Homo sapiens 4-7 2846391-2 1988 The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells. Phosphatidylcholines 67-69 cut like homeobox 1 Homo sapiens 4-7 3230188-7 1988 Comparison of fatty acid profiles for phosphatidylcholine with those for lysophosphatidylcholine and cholesterol esters indicated plasma lecithin-cholesterol acyltransferase was active in calves at all three ages studied. Phosphatidylcholines 38-57 lecithin-cholesterol acyltransferase Bos taurus 137-173 2849424-6 1988 The effects of isoprenaline, oxytocin and insulin on the incorporation of [3H]choline into phosphatidylcholine were paralleled by changes in the activity of CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 91-110 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 157-196 3199820-3 1988 GR was present at least 2 days prior to gestational day 18, from which day maternal betamethasone administration stimulated choline chloride incorporation into phosphatidylcholine, the major phospholipid in surfactant. Phosphatidylcholines 160-179 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 0-2 3170606-8 1988 Upon chromatography of the PC-stabilized enzyme on concanavalin A-agarose almost complete retention occurred at 0.4% Nonidet P-40, while no binding took place at a detergent concentration of 0.075%; this suggested that upon dilution in the presence of PC, the oligosaccharyltransferase was reconstituted into vesicles in an asymmetric fashion with its N-linked carbohydrate located internally. Phosphatidylcholines 27-29 interleukin 9 Homo sapiens 125-129 3178828-1 1988 This report demonstrates that exogenous phosphatidylcholine will serve as an acyl donor for the esterification of retinol complexed to cellular retinol-binding protein (CRBP) by human and rat liver microsomal preparations. Phosphatidylcholines 40-59 retinol binding protein 1 Homo sapiens 135-167 3178828-1 1988 This report demonstrates that exogenous phosphatidylcholine will serve as an acyl donor for the esterification of retinol complexed to cellular retinol-binding protein (CRBP) by human and rat liver microsomal preparations. Phosphatidylcholines 40-59 retinol binding protein 1 Homo sapiens 169-173 3149278-3 1988 Phosphatidylcholine or phosphatidylethanolamine with arachidonate at the sn-2 position of glycerol was cleaved efficiently by phospholipase A2 activity in homogenates as well as in the cytoplasmic fraction of human platelets, leading to the selective liberation of free arachidonate, whereas phospholipids with linoleate were hardly hydrolyzed under the same conditions. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 126-142 3139038-2 1988 The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate. Phosphatidylcholines 85-104 lactalbumin alpha Bos taurus 195-212 3139038-2 1988 The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate. Phosphatidylcholines 85-104 lactalbumin alpha Bos taurus 239-256 3139038-7 1988 The presence of phosphatidylcholine abolished the break demonstrating that full activity of the enzyme required both alpha-lactalbumin and lipid. Phosphatidylcholines 16-35 lactalbumin alpha Bos taurus 117-134 3207703-0 1988 Equilibrium and dynamic bilayer structural properties of unsaturated acyl chain phosphatidylcholine-cholesterol-rhodopsin recombinant vesicles and rod outer segment disk membranes as determined from higher order analysis of fluorescence anisotropy decay. Phosphatidylcholines 80-99 rhodopsin Bos taurus 112-121 3196662-8 1988 Owing to the high lipid aqueous partition coefficient of BaP, it is concluded that the direct adsorption of BaP on to the fibres will be negligible when PC is present in the system even at low concentrations. Phosphatidylcholines 153-155 prohibitin 2 Homo sapiens 108-111 3242951-7 1988 Our model also explains the facilitation of precipitation observed when phosphatidylcholine is contained in the palmitate-bile salt mixed micelles and the inhibitory effect of the water soluble bovine serum albumin. Phosphatidylcholines 72-91 albumin Homo sapiens 201-214 3143410-4 1988 In general, increasing the pi i of lipid monolayers reduces the adsorption of apolipoprotein A-I; for expanded egg phosphatidylcholine (PC) monolayers at pi i greater than or equal to 32 dyn/cm, gamma and delta pi are zero. Phosphatidylcholines 115-134 apolipoprotein A1 Homo sapiens 78-96 3420613-3 1988 Metyrapone also reduced the CCl4-related increase in the PLC-mediated reductions in cellular phosphatidylcholine content. Phosphatidylcholines 93-112 C-C motif chemokine ligand 4 Rattus norvegicus 28-32 2850468-5 1988 In cho2 and opi3 mutants, which are blocked in phosphatidylcholine synthesis, inositol-mediated repression of PGPS did not occur unless choline was added to the media. Phosphatidylcholines 47-66 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 12-16 3235916-0 1988 Cyclopentanoid analogs of phosphatidylcholine: susceptibility to phospholipase A2. Phosphatidylcholines 26-45 phospholipase A2 group IB Homo sapiens 65-81 3050446-1 1988 Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes. Phosphatidylcholines 153-172 G protein-coupled receptor kinase 7 Bos taurus 0-16 3050446-1 1988 Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes. Phosphatidylcholines 153-172 rhodopsin Bos taurus 120-129 3410848-6 1988 Here we report that this activity in intestinal microsomes will catalyze the transfer of acyl moieties from exogenous phosphatidylcholine (PC) to retinol-CRBP(II) to produce retinyl esters. Phosphatidylcholines 118-137 retinol binding protein 2 Rattus norvegicus 154-161 3410848-6 1988 Here we report that this activity in intestinal microsomes will catalyze the transfer of acyl moieties from exogenous phosphatidylcholine (PC) to retinol-CRBP(II) to produce retinyl esters. Phosphatidylcholines 139-141 retinol binding protein 2 Rattus norvegicus 154-161 3410848-7 1988 The microsomal activity displayed positional selectivity as only the sn-1-acyl moiety of PC was transferred to retinol-CRBP(II). Phosphatidylcholines 89-91 retinol binding protein 2 Rattus norvegicus 119-127 3166380-6 1988 Substituting the neutral phosphatidylcholine with the negatively-charged phosphatidylserine vesicles resulted in a slower rate as well as lesser total uptake of P12. Phosphatidylcholines 25-44 DNA polymerase epsilon 4, accessory subunit Homo sapiens 161-164 2840908-7 1988 Phosphatidylinositol and phosphatidylcholine hydrolysis measured upon thrombin treatment as well as phosphatidic acid production were reduced or suppressed in the presence of the drugs. Phosphatidylcholines 25-44 coagulation factor II, thrombin Homo sapiens 70-78 3137572-1 1988 Spin-labeled phospholipids have been used to study the outside----inside and inside----outside transport of phospholipids across the human erythrocyte membrane at 37 degrees C. As already shown, inward transport is much faster for aminophospholipids than for phosphatidylcholine. Phosphatidylcholines 259-278 spindlin 1 Homo sapiens 0-4 3417866-4 1988 In contrast, exogenous PLA2 treatment of hypoxic tubules resulted in a severe degree of cell injury, as demonstrated by marked declines in tubule K+ and ATP contents and significant decreases in tubule uncoupled respiratory rates, and was associated with significant phospholipid alterations, including marked declines in phosphatidylcholine (PC) and PE and significant rises in LPC, LPE, and free fatty acids (FFA). Phosphatidylcholines 322-341 phospholipase A2 Oryctolagus cuniculus 23-27 3417866-4 1988 In contrast, exogenous PLA2 treatment of hypoxic tubules resulted in a severe degree of cell injury, as demonstrated by marked declines in tubule K+ and ATP contents and significant decreases in tubule uncoupled respiratory rates, and was associated with significant phospholipid alterations, including marked declines in phosphatidylcholine (PC) and PE and significant rises in LPC, LPE, and free fatty acids (FFA). Phosphatidylcholines 343-345 phospholipase A2 Oryctolagus cuniculus 23-27 2971218-2 1988 We have measured phosphatidylinositol-specific phospholipase C and phosphatidylcholine-specific phospholipase A2 in the reproductive tract of male and female mouse (CD-I) fetuses at the 18th day of gestation. Phosphatidylcholines 67-86 phospholipase A2, group IB, pancreas Mus musculus 96-112 3403556-0 1988 Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase A2. Phosphatidylcholines 14-33 phospholipase A2 group IB Homo sapiens 96-112 3403556-0 1988 Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase A2. Phosphatidylcholines 37-56 phospholipase A2 group IB Homo sapiens 96-112 3403556-1 1988 Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates. Phosphatidylcholines 68-87 phospholipase A2 group IB Homo sapiens 11-27 3403556-1 1988 Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates. Phosphatidylcholines 68-87 phospholipase A2 group IB Homo sapiens 29-33 3403556-1 1988 Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates. Phosphatidylcholines 89-91 phospholipase A2 group IB Homo sapiens 11-27 3403556-1 1988 Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates. Phosphatidylcholines 89-91 phospholipase A2 group IB Homo sapiens 29-33 3044366-1 1988 Insulin was found to provoke simultaneous, rapid, biphasic increases in [3H]choline-labeling of phosphatidylcholine and phosphocholine in BC3H-1 myocytes. Phosphatidylcholines 96-115 insulin Homo sapiens 0-7 3178736-4 1988 After an initial lag of 30 min, the release of [3H]lysophosphatidylcholine was linear for at least 4 h. At low concentrations, albumin slightly stimulated [3H]phosphatidylcholine release. Phosphatidylcholines 55-74 albumin Rattus norvegicus 127-134 3401474-0 1988 The effect of alpha-lactalbumin on the thermotropic phase behaviour of phosphatidylcholine bilayers, studied by fluorescence polarization, differential scanning calorimetry and Raman spectroscopy. Phosphatidylcholines 71-90 lactalbumin alpha Bos taurus 14-31 3045250-0 1988 Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Phosphatidylcholines 90-110 CD5 molecule Homo sapiens 62-65 3136794-0 1988 A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo. Phosphatidylcholines 31-50 coagulation factor VIII Canis lupus familiaris 88-99 3136794-1 1988 A combination of phosphatidylcholine-phosphatidylserine lipid vesicles (PCPS), as a source of coagulant active phospholipid, when infused with factor Xa bypasses factor VIII in vivo. Phosphatidylcholines 17-36 coagulation factor VIII Canis lupus familiaris 162-173 3396665-3 1988 Therefore, we have examined the effect of TCE on the intra- and extracellular surfactant pools and the activity of phospholipase A2, an enzyme which controls the remodeling of phosphatidylcholine to dipalmitoylphosphatidylcholine, the primary constituent of the pulmonary surfactant. Phosphatidylcholines 176-195 phospholipase A2, group IB, pancreas Mus musculus 115-131 2898301-3 1988 Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells. Phosphatidylcholines 135-154 interleukin 1 alpha Homo sapiens 41-45 2847107-3 1988 Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid. Phosphatidylcholines 124-143 LOW QUALITY PROTEIN: thyrotropin-releasing hormone Ovis aries 52-55 2847107-3 1988 Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid. Phosphatidylcholines 214-233 LOW QUALITY PROTEIN: thyrotropin-releasing hormone Ovis aries 52-55 2847107-3 1988 Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid. Phosphatidylcholines 214-233 LOW QUALITY PROTEIN: thyrotropin-releasing hormone Ovis aries 52-55 2898301-3 1988 Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells. Phosphatidylcholines 156-158 interleukin 1 alpha Homo sapiens 60-64 3183519-14 1988 Lamellar body phosphatidylcholine contained four monoenoic fatty acids: 1) palmitoleic acid, 16:1 cis-9; 2) oleic acid, 18:1 cis-9; 3) cis-vaccenic acid, 18:1 cis-11; and 4) 6-hexadecenoic acid, 16:1 cis-6. Phosphatidylcholines 14-33 suppressor of cytokine signaling 5 Homo sapiens 200-205 3132984-0 1988 Transformation of large discoidal complexes of apolipoprotein A-I and phosphatidylcholine by lecithin-cholesterol acyltransferase. Phosphatidylcholines 70-89 lecithin-cholesterol acyltransferase Homo sapiens 93-129 2898301-3 1988 Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells. Phosphatidylcholines 156-158 interleukin 1 alpha Homo sapiens 41-45 2898301-3 1988 Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells. Phosphatidylcholines 135-154 interleukin 1 alpha Homo sapiens 60-64 3382674-0 1988 Regulation of the human leukocyte 5-lipoxygenase: stimulation by micromolar Ca2+ levels and phosphatidylcholine vesicles. Phosphatidylcholines 92-111 arachidonate 5-lipoxygenase Homo sapiens 34-48 3134504-5 1988 Arachidonic acid utilized in the production of eicosanoids is derived from phospholipids by the action of phospholipase A2 and phospholipase C. When U937 cells were cultured in medium supplemented with gamma-interferon, there was a striking increase in the level of phosphatidylcholine and phosphatidylethanolamine-specific phospholipase A2 activities and phosphatidylinositol-specific phospholipase C activity as compared to control cells. Phosphatidylcholines 266-285 phospholipase A2 group IB Homo sapiens 106-122 3382674-2 1988 In the present study, phosphatidylcholine (PC) vesicles, in the absence of 100,000 x g pellet, exhibited a dose-dependent stimulatory activity on the 5-lipoxygenase, which was at least as effective as the 100,000 x g pellet. Phosphatidylcholines 22-41 arachidonate 5-lipoxygenase Homo sapiens 150-164 3391168-7 1988 When bovine intact cytochrome b5 was reconstituted into egg yolk phosphatidylcholine liposomes, although separate signals due to the protein part were observed in the normal 1H-NMR spectrum, no photo-CIDNP signal could be detected. Phosphatidylcholines 65-84 cytochrome b5 type A Bos taurus 19-32 2459283-3 1988 Filipin successfully stained discoidal complexes of apoA-I-phosphatidylcholine-cholesterol, which in turn were stained poorly with oil red O. Phosphatidylcholines 59-78 apolipoprotein A1 Homo sapiens 52-58 3130896-7 1988 It is concluded that in hepatocytes vasopressin increases diacylglycerols by a process which does not principally involve the conversion of phosphoinositides to diacylglycerol or the de novo synthesis of diacylglycerol from glycerol 3-phosphate, but does involve the Ca2+-dependent conversion of phosphatidylethanolamine and phosphatidylcholine to diacylglycerol. Phosphatidylcholines 325-344 arginine vasopressin Homo sapiens 36-47 3227920-0 1988 Plasma pattern of growth hormone regulates sexual differentiation of phosphatidylcholine in rat plasma. Phosphatidylcholines 69-88 gonadotropin releasing hormone receptor Rattus norvegicus 18-32 2971392-6 1988 In one such case involving liposomes composed of PA/PS/PE/phosphatidylcholine (PC) (10:15:65:10), synexin reduced the fusion rate constant by 50%. Phosphatidylcholines 58-77 annexin A7 Homo sapiens 98-105 3131322-1 1988 The kinetics of the Ca2+-dependent, alkaline pH optimum, membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line were studied using various phosphatidylcholine (PC) and phosphatidylethanolamine (PE) substrates. Phosphatidylcholines 158-177 phospholipase A2, group IB, pancreas Mus musculus 72-88 3133132-6 1988 In hypoxic myocardium, this phospholipase A2 activity markedly increased and had substrate specificity toward phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 110-129 phospholipase A2 group IB Rattus norvegicus 28-44 2458317-3 1988 Chromatographic analysis of [3H]arachidonic acid labeled phospholipids showed that stimulation by FMLP reduced the amount of labeled phosphatidylcholine exclusively. Phosphatidylcholines 133-152 formyl peptide receptor 1 Homo sapiens 98-102 3284590-1 1988 Protein-mediated transfer of phosphatidylcholine (PC) by bovine liver phosphatidylcholine transfer protein (PC-TP) was examined using a vesicle-vesicle assay system. Phosphatidylcholines 29-48 phosphatidylcholine transfer protein Bos taurus 108-113 2835102-1 1988 The intramembrane locations of several spin labeled probes in small egg phosphatidylcholine (egg PC) vesicles were determined from the enhancement of the 13C nuclear spin lattice relaxation of the membrane phospholipid. Phosphatidylcholines 72-91 spindlin 1 Homo sapiens 39-43 2835102-1 1988 The intramembrane locations of several spin labeled probes in small egg phosphatidylcholine (egg PC) vesicles were determined from the enhancement of the 13C nuclear spin lattice relaxation of the membrane phospholipid. Phosphatidylcholines 72-91 spindlin 1 Homo sapiens 166-170 3238311-5 1988 We found that the release of both AA and NAG was coupled to a degradation of phosphatidylcholine (PC), and that the neutrophils were able to metabolise lower, but not higher, concentrations of lysoPC. Phosphatidylcholines 77-96 O-GlcNAcase Homo sapiens 41-44 3238311-5 1988 We found that the release of both AA and NAG was coupled to a degradation of phosphatidylcholine (PC), and that the neutrophils were able to metabolise lower, but not higher, concentrations of lysoPC. Phosphatidylcholines 98-100 O-GlcNAcase Homo sapiens 41-44 3238311-6 1988 Moreover, the phospholipase A2 inhibitor, nordihydroguaiaretic acid significantly inhibited PC degradation, lysoPC formation, and NAG release, whereas the lipoxygenase inhibitor, BW 755C had little effect on these parameters. Phosphatidylcholines 92-94 phospholipase A2 group IB Homo sapiens 14-30 3365445-5 1988 The results indicated that in rat platelets, PC synthesis occurred mainly via the CDP-choline pathway, and suggested that CTP:phosphocholine cytidylyltransferase was the rate-limiting step; they also indicated that the activity of this enzyme and that of choline kinase might be enhanced in SHR platelets compared to Wistar-Kyoto rat (WKY) platelets, and may thus be responsible for the enhanced PC synthesis. Phosphatidylcholines 396-398 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 122-161 3284590-1 1988 Protein-mediated transfer of phosphatidylcholine (PC) by bovine liver phosphatidylcholine transfer protein (PC-TP) was examined using a vesicle-vesicle assay system. Phosphatidylcholines 50-52 phosphatidylcholine transfer protein Bos taurus 108-113 3284590-7 1988 In addition, kinetic analysis revealed that the presence of PC in acceptor vesicles increased both the association and dissociation of PC-TP from vesicles. Phosphatidylcholines 60-62 phosphatidylcholine transfer protein Bos taurus 135-140 3284590-10 1988 The results suggest that transfer of PC by PC-TP is enhanced only when insertion of protein-bound PC occurs concurrently with the extraction of a molecule of membrane PC, i.e., a concerted, one-step catalytic mechanism for phospholipid exchange. Phosphatidylcholines 37-39 phosphatidylcholine transfer protein Bos taurus 43-48 2833508-2 1988 Under these conditions, CTP:phosphocholine cytidylyltransferase activity, which is known to catalyze the rate-limiting step in phosphatidylcholine biosynthesis, was stimulated 32% (p less than 0.001) over control cells. Phosphatidylcholines 127-146 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 24-63 3202919-3 1988 The composition of the fatty acids in phosphatidylcholine in the outer leaflet of the bilayer was determined after hydrolysis of outer leaflet phospholipids, first with phospholipase A2 and subsequently with sphingomyelinase. Phosphatidylcholines 38-57 phospholipase A2 group IB Rattus norvegicus 169-185 2833508-8 1988 We further conclude that the final step in the de novo pathway for PAF biosynthesis is under the direct control of CTP:phosphocholine cytidylyltransferase, which emphasizes the importance of this regulatory (rate-limiting) step in the biosynthesis of both phosphatidylcholine and PAF. Phosphatidylcholines 256-275 patchy fur Mus musculus 67-70 2833508-8 1988 We further conclude that the final step in the de novo pathway for PAF biosynthesis is under the direct control of CTP:phosphocholine cytidylyltransferase, which emphasizes the importance of this regulatory (rate-limiting) step in the biosynthesis of both phosphatidylcholine and PAF. Phosphatidylcholines 256-275 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 115-154 3365241-0 1988 Vasopressin is the only component of serum-free medium that stimulates phosphatidylcholine hydrolysis and accumulation of diacylglycerol in cultured REF52 cells. Phosphatidylcholines 71-90 arginine vasopressin Rattus norvegicus 0-11 3365241-1 1988 Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels). Phosphatidylcholines 23-42 arginine vasopressin Rattus norvegicus 0-11 3365241-1 1988 Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels). Phosphatidylcholines 79-98 arginine vasopressin Rattus norvegicus 0-11 3365241-2 1988 Vasopressin is the only component of a 6-component mixture of the serum-free medium for REF52 cells that induces the phosphatidylcholine hydrolysis response. Phosphatidylcholines 117-136 arginine vasopressin Rattus norvegicus 0-11 2833496-1 1988 The plasma cholesteryl ester-transfer protein (CETP, Mr 74,000) promotes exchange of both neutral lipids and phospholipids (phosphatidylcholine, PC) between lipoproteins. Phosphatidylcholines 124-143 cholesteryl ester transfer protein Homo sapiens 11-45 3365241-4 1988 Maximal levels of both phosphatidyl-choline hydrolysis and accumulation of diacylglycerol are observed between 10 and 20 min after treatment with vasopressin. Phosphatidylcholines 23-43 arginine vasopressin Rattus norvegicus 146-157 3365241-5 1988 Effects are maximal at vasopressin concentrations of 100 ng/ml; the ED50 for vasopressin-stimulated phosphatidyl-choline hydrolysis is approximately 0.7 ng/ml. Phosphatidylcholines 100-120 arginine vasopressin Rattus norvegicus 77-88 3355851-0 1988 Sex differences in fatty acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth hormone. Phosphatidylcholines 55-74 gonadotropin releasing hormone receptor Rattus norvegicus 114-128 2833521-19 1988 The results support the hypothesis that Golgi has the capacity to make certain phospholipids for lipoprotein secretion: phosphatidylcholine via the CDP-choline and methylation pathways, phosphatidylethanolamine by the CDP-ethanolamine pathway, and phosphatidylserine. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 148-151 3128333-8 1988 Similar experiments using cholesteryl linoleate/egg phosphatidylcholine liposomes showed that inclusion of apo A-I resulted in a pronounced increase in the uptake of cholesteryl linoleate and progestin synthesis. Phosphatidylcholines 52-71 apolipoprotein A1 Rattus norvegicus 107-114 2833496-1 1988 The plasma cholesteryl ester-transfer protein (CETP, Mr 74,000) promotes exchange of both neutral lipids and phospholipids (phosphatidylcholine, PC) between lipoproteins. Phosphatidylcholines 124-143 cholesteryl ester transfer protein Homo sapiens 47-51 3170511-4 1988 The L929 cells excreted the degradation products of TNF into the culture medium, and this medium showed activity for degradation of liposomes composed of phosphatidylserine and phosphatidylcholine. Phosphatidylcholines 177-196 tumor necrosis factor Mus musculus 52-55 2831902-0 1988 Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells. Phosphatidylcholines 89-108 arginine vasopressin Homo sapiens 18-29 3378037-0 1988 Kinetics of fluorescent-labeled phosphatidylcholine transfer between nonspecific lipid transfer protein and phospholipid vesicles. Phosphatidylcholines 32-51 sterol carrier protein 2 Rattus norvegicus 69-103 2454133-5 1988 However, a redistribution of both gramicidin and dansyl-labeled phospholipids was easily observed when a phase separation was induced by adding Ca2+ to vesicles made up of phosphatidylcholine and phosphatidic acid. Phosphatidylcholines 172-191 carbonic anhydrase 2 Homo sapiens 144-147 2454133-6 1988 Polarization measurements showed that in the presence of Ca2+ a rigid phosphatidic acid rich region and a more fluid phosphatidylcholine-rich region were formed. Phosphatidylcholines 117-136 carbonic anhydrase 2 Homo sapiens 57-60 2974829-3 1988 In kinetic studies, all of the above proteases stimulated the deacylation of phosphatidylcholine (PC); in fresh spermatozoa, trypsin showed a higher activation potential than kallikrein or plasmin. Phosphatidylcholines 77-96 kallikrein related peptidase 4 Homo sapiens 175-185 2830903-0 1988 Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond. Phosphatidylcholines 47-74 arginine vasopressin Rattus norvegicus 0-11 2830903-6 1988 Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium. Phosphatidylcholines 236-255 arginine vasopressin Rattus norvegicus 93-104 2830903-11 1988 Further, collateral with vasopressin-induced phosphatidylcholine hydrolysis, the cellular release of arachidonic acid occurs. Phosphatidylcholines 45-64 arginine vasopressin Rattus norvegicus 25-36 3198053-6 1988 The PA2 activity associated with normal spermatozoa exhibited a 60% decrease in activity after storage at -20 degrees C for 48 hr followed by a heating period of 10 min at 60 degrees C. Long-term storage of spermatozoa at -20 degrees C also resulted in a similar decrease in the deacylation of PC. Phosphatidylcholines 294-296 phospholipase A2 group IB Homo sapiens 4-7 3365383-4 1988 After hexane extraction of lyophilized disks, PC is the major component of the fraction of lipids that remains associated with rhodopsin, followed by phosphatidylserine, while a large proportion of the phosphatidylethanolamine is removed. Phosphatidylcholines 46-48 rhodopsin Bos taurus 127-136 3365383-7 1988 VLCPUFA-containing PCs are the most highly concentrated species in the rhodopsin-associated lipid fraction. Phosphatidylcholines 19-22 rhodopsin Bos taurus 71-80 3342232-4 1988 In the presence of 1% CHAPS, hydrolysis of exogenous phosphatidylcholine was shown to be due to an initial phospholipase A2-type attack followed by a subsequent lysophospholipase-type attack. Phosphatidylcholines 53-72 phospholipase A2 group IB Rattus norvegicus 107-123 3342232-4 1988 In the presence of 1% CHAPS, hydrolysis of exogenous phosphatidylcholine was shown to be due to an initial phospholipase A2-type attack followed by a subsequent lysophospholipase-type attack. Phosphatidylcholines 53-72 asparaginase Rattus norvegicus 161-178 2893798-4 1988 The limiting step in phosphatidylcholine biosynthesis was the formation of CDP-choline catalyzed by CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15) as monitored by the decrease in phosphocholine labeling following phospholipase C treatment of cells prelabeled with [3H]choline. Phosphatidylcholines 21-40 cut like homeobox 1 Homo sapiens 75-78 3129527-5 1988 Therefore, phospholipase A2 activity was calculated as the rate of the release of arachidonic acid from phosphatidylcholine under the conditions used. Phosphatidylcholines 104-123 phospholipase A2 group IB Homo sapiens 11-27 3342248-1 1988 The influence of variation of the phospholipid composition in model membranes composed of phosphatidylcholine and phosphatidylethanolamine on the hydrolysis of these phospholipids by rat liver mitochondrial phospholipase A2 was investigated. Phosphatidylcholines 90-109 phospholipase A2 group IB Rattus norvegicus 207-223 2974829-3 1988 In kinetic studies, all of the above proteases stimulated the deacylation of phosphatidylcholine (PC); in fresh spermatozoa, trypsin showed a higher activation potential than kallikrein or plasmin. Phosphatidylcholines 77-96 plasminogen Homo sapiens 189-196 3349060-1 1988 13C NMR spectroscopy was used to probe the structural interactions between carboxyl-13C-enriched oleic acid (18:1) and rat liver fatty acid binding protein (FABP) and the partitioning of 18:1 between FABP and unilamellar phosphatidylcholine (PC) vesicles. Phosphatidylcholines 221-240 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 157-161 3123482-2 1988 We have studied the phospholipase A2 activity in fractionated human neutrophils, employing labeled phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine as exogenous substrates. Phosphatidylcholines 121-140 phospholipase A2 group IB Homo sapiens 20-36 3123482-10 1988 Phosphatidylinositol was a better substrate for the plasma membrane enzyme, whereas phosphatidylcholine and phosphatidylethanolamine behaved as better substrates for intracellular organelle phospholipase A2 activities. Phosphatidylcholines 84-103 phospholipase A2 group IB Homo sapiens 190-206 2894457-2 1988 Previous studies have indicated that bradykinin stimulates arachidonic acid release in Swiss 3T3 cells by activating phospholipase A2 and by activating phosphatidylcholine-specific phospholipase C in CPAE cells. Phosphatidylcholines 152-171 kininogen 1 Bos taurus 37-47 2446664-4 1988 However, myelin basic protein was labeled 2-4-times more when bound to the acidic lipids phosphatidylglycerol, phosphatidylserine, phosphatidic acid, and cerebroside sulfate than when bound to phosphatidylethanolamine, or when in solution in the presence of phosphatidylcholine vesicles. Phosphatidylcholines 258-277 myelin basic protein Homo sapiens 9-29 3336410-0 1988 Prevention by choline of the depletion of membrane phosphatidylcholine by a cholinesterase inhibitor. Phosphatidylcholines 51-70 butyrylcholinesterase Homo sapiens 76-90 3337718-4 1988 In addition, ATP is shown to inhibit, and phosphatidylcholine is shown to stimulate, 15-lipoxygenase, suggesting a regulatory role for these compounds in the lipoxygenation of arachidonic acid. Phosphatidylcholines 42-61 arachidonate 15-lipoxygenase Homo sapiens 85-100 3337803-3 1988 Protein 4.1 penetrated into monolayers of brain phosphatidylserine (PS) and egg phosphatidylcholine (PC), even above surface pressures of 30 mN/m. Phosphatidylcholines 80-99 erythrocyte membrane protein band 4.1 Homo sapiens 0-11 3146672-0 1988 Influence of a beta-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung. Phosphatidylcholines 78-97 amyloid beta precursor protein Rattus norvegicus 13-19 3384576-14 1988 Phospholipase A2 detaches the fatty acid from the position of phosphatidyl choline, and the lysolecithin formed has a detergent effect that can produce membrane destabilization. Phosphatidylcholines 62-82 phospholipase A2 group IB Rattus norvegicus 0-16 2826503-2 1988 Initial phospholipid analysis by two-dimensional thin layer chromatography (2-D TLC) reveals a significant increase in the amount of 32P-labeled phosphatidylcholine in the Thy-1 capped membrane. Phosphatidylcholines 145-164 thymus cell antigen 1, theta Mus musculus 172-177 2826503-4 1988 Therefore, it is suggested that phosphatidylcholine may be involved in the organization and/or regulation of Thy-1 antigen redistribution. Phosphatidylcholines 32-51 thymus cell antigen 1, theta Mus musculus 109-122 3680298-1 1987 Phosphatidylethanolamine (PE) N-methyltransferase catalyzes the synthesis of phosphatidylcholine by the stepwise transfer of methyl groups from S-adenosylmethionine to the amino head group of PE. Phosphatidylcholines 77-96 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-49 3163212-3 1988 In addition, the increased synthesis of ara-CDP-choline associated with these high doses may serve as an alternate substrate for phosphatidyl choline synthesis, which may contribute to membrane fragility and cell lysis. Phosphatidylcholines 129-149 cut like homeobox 1 Homo sapiens 44-47 3121598-5 1987 In mixed phospholipid vesicles containing PS and phosphatidylcholine in various molar ratios, the extent of PAI-1 activation was directly related to the PS content of the phospholipid membrane. Phosphatidylcholines 49-68 serpin family E member 1 Homo sapiens 108-113 3126801-6 1987 Although apo A-I interacted spontaneously with DMPC at 25 degrees C, it was necessary to dilute mixed micellar solutions of sodium taurocholate (TC) and egg yolk phosphatidylcholine (EYPC) with apo A-I solutions to form apo A-I/EYPC mixed micelles. Phosphatidylcholines 162-181 apolipoprotein A1 Homo sapiens 194-201 3126801-6 1987 Although apo A-I interacted spontaneously with DMPC at 25 degrees C, it was necessary to dilute mixed micellar solutions of sodium taurocholate (TC) and egg yolk phosphatidylcholine (EYPC) with apo A-I solutions to form apo A-I/EYPC mixed micelles. Phosphatidylcholines 162-181 apolipoprotein A1 Homo sapiens 194-201 20501314-5 1988 For the metabolism of phosphatidylcholine the measured enzymes were CTP: phosphocholine cytidylyltransferase and CDP-choline: diacylglycerol cholinephosphotransferase. Phosphatidylcholines 22-41 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 68-108 2829843-2 1987 Reconstitution of the receptor kinase into leaky vesicles containing phosphatidylcholine and phosphatidylethanolamine (1:1, w/w) by detergent removal on Sephadex G-50 results in the complete loss of receptor kinase sensitivity to activation by insulin. Phosphatidylcholines 69-88 insulin Homo sapiens 244-251 2829843-9 1987 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. Phosphatidylcholines 221-240 insulin Homo sapiens 57-64 2829843-9 1987 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. Phosphatidylcholines 221-240 insulin Homo sapiens 160-167 2825797-6 1987 These activities co-purified during the entire purification procedure, indicating that the acid sphingomyelinase hydrolyses not only sphingomyelin but also the other two phospholipids, phosphatidylcholine and phosphatidylglycerol. Phosphatidylcholines 185-204 sphingomyelin phosphodiesterase 1 Homo sapiens 91-112 3689818-0 1987 Contamination of commercial phosphatidylcholine by phospholipase A. Phosphatidylcholines 28-47 phospholipase A and acyltransferase 1 Homo sapiens 51-66 3118953-1 1987 NADPH-cytochrome P-450 reductase, purified from bovine adrenocortical microsomes, was shown to bind in two different modes to liposomal membranes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine at a molar ratio of 5:3:1. Phosphatidylcholines 158-177 cytochrome p450 oxidoreductase Bos taurus 0-32 3427105-1 1987 Low-angle neutron scattering is used to study the binding of human prothrombin to small single-bilayer vesicles consisting of phosphatidylcholine and phosphatidylserine (1/1 w/w). Phosphatidylcholines 126-145 coagulation factor II, thrombin Homo sapiens 67-78 3315823-3 1987 Elevated phosphatidylcholine and reduced lysophosphatidylcholine fractions indicated impairment of cholesterol esterification by lecithin-cholesterol acyltransferase. Phosphatidylcholines 9-28 lecithin-cholesterol acyltransferase Homo sapiens 129-165 3479781-3 1987 Bilirubin ditaurine (BR-DT), a water-soluble model compound of conjugated bilirubin, completely prevents the peroxyl radical-induced oxidation of phosphatidylcholine in either multilamellar liposomes or micelles. Phosphatidylcholines 146-165 bromodomain testis associated Homo sapiens 0-26 3117799-9 1987 Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate. Phosphatidylcholines 5-24 arginine vasopressin Rattus norvegicus 184-195 3117799-9 1987 Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate. Phosphatidylcholines 230-249 arginine vasopressin Rattus norvegicus 184-195 3676313-0 1987 Activity of bile-salt-stimulated human milk lipase in the presence of liposomes and mixed taurocholate-phosphatidylcholine micelles. Phosphatidylcholines 103-122 carboxyl ester lipase Homo sapiens 39-50 3676318-0 1987 Leakage from egg phosphatidylcholine vesicles induced by Ca2+ and alcohols. Phosphatidylcholines 17-36 carbonic anhydrase 2 Homo sapiens 57-60 3676318-1 1987 The results shown in this paper indicate that the permeability properties of egg yolk phosphatidylcholine sonicated vesicles as detected by the leakage of carboxy fluorescein changes according to the Ca2+ content. Phosphatidylcholines 86-105 carbonic anhydrase 2 Homo sapiens 200-203 2445736-6 1987 In contrast, the membrane fraction from the transformants carrying PEM2 catalyzed the synthesis of phosphatidylcholine (PC) from PE, indicating that it contains all of the three methylation activities. Phosphatidylcholines 99-118 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 67-71 2445736-6 1987 In contrast, the membrane fraction from the transformants carrying PEM2 catalyzed the synthesis of phosphatidylcholine (PC) from PE, indicating that it contains all of the three methylation activities. Phosphatidylcholines 120-122 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 67-71 2445736-9 1987 The results of phospholipid composition analysis showed that the PEM1 transformant accumulated PMME whereas the PEM2 transformant contained a decreased amount of PC. Phosphatidylcholines 162-164 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 112-116 2959321-2 1987 The permeability of lipid bilayers to Co2+ and glucose was increased slightly by incorporation of the ATPase, and the permeability of mixed bilayers of phosphatidylethanolamine and phosphatidylcholine increased with increasing content of phosphatidylethanolamine both in the presence and absence of the ATPase. Phosphatidylcholines 181-200 dynein axonemal heavy chain 8 Homo sapiens 303-309 3427069-2 1987 The phosphatidylcholine transfer protein from bovine liver has specific binding sites for the sn-1 and sn-2 acyl chains of the phosphatidylcholine molecule [Berkhout, T.A., Visser, A.J. Phosphatidylcholines 4-23 solute carrier family 38 member 5 Bos taurus 103-107 3427069-2 1987 The phosphatidylcholine transfer protein from bovine liver has specific binding sites for the sn-1 and sn-2 acyl chains of the phosphatidylcholine molecule [Berkhout, T.A., Visser, A.J. Phosphatidylcholines 127-146 solute carrier family 38 member 5 Bos taurus 103-107 3428670-3 1987 Pretreatment with the phospholipase A2 inhibitor, quinacrine, prevented the increases in mucosal phospholipase A2 activity and lysophosphatidylcholine/phosphatidylcholine ratio after ischaemia and morphological examinations revealed that the mucosa was then also protected against ischaemic injury. Phosphatidylcholines 131-150 phospholipase A2 group IB Rattus norvegicus 22-38 3125165-4 1987 On the other hand, liposomes composed of neutral phospholipids such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin showed little increases in permeability when incubated with TNF above pH 5.0. Phosphatidylcholines 71-90 tumor necrosis factor Mus musculus 196-199 2446313-9 1987 CAT activity in RDM-4 cells from mice injected with DNA entrapped in pH-insensitive immunoliposomes (containing phosphatidylcholine in place of phosphatidylethanolamine) was approximately one-fourth that in RDM-4 cells from mice injected with pH-sensitive immunoliposomes, indicating the superior delivery efficiency of the pH-sensitive liposomes. Phosphatidylcholines 112-131 chloramphenicol acetyltransferase Escherichia coli 0-3 3654657-0 1987 Binding of fluorescent-labeled phosphatidylcholine to rat liver nonspecific lipid transfer protein. Phosphatidylcholines 31-50 sterol carrier protein 2 Rattus norvegicus 64-98 2447937-3 1987 On the other hand, gramicidin enhances the rate of cleavage of outer membrane layer phosphatidylcholine by phospholipase A2, which indicates changes in the packing of phosphatidylcholine following gramicidin binding. Phosphatidylcholines 84-103 phospholipase A2 group IB Homo sapiens 107-123 2447937-3 1987 On the other hand, gramicidin enhances the rate of cleavage of outer membrane layer phosphatidylcholine by phospholipase A2, which indicates changes in the packing of phosphatidylcholine following gramicidin binding. Phosphatidylcholines 167-186 phospholipase A2 group IB Homo sapiens 107-123 3117787-0 1987 Thyrotropin-releasing hormone and phorbol esters induce phosphatidylcholine synthesis in GH3 pituitary cells. Phosphatidylcholines 56-75 thyrotropin releasing hormone Rattus norvegicus 0-29 3117787-1 1987 Evidence for stimulation via protein kinase C. Phorbol esters have been shown to stimulate phosphatidylcholine synthesis via the CDP-choline pathway. Phosphatidylcholines 91-110 cut-like homeobox 1 Rattus norvegicus 129-132 3117787-2 1987 The present study compares the effects of phorbol esters and thyrotropin-releasing hormone (TRH) on phosphatidylcholine metabolism in GH3 pituitary cells. Phosphatidylcholines 100-119 thyrotropin releasing hormone Rattus norvegicus 61-90 2820490-5 1987 (2) Spin-labeled lipophilic cations were synthesized and the binding to liposomes of egg phosphatidylcholine was examined. Phosphatidylcholines 89-108 spindlin 1 Homo sapiens 4-8 3651600-1 1987 The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Phosphatidylcholines 4-23 phosphatidylcholine transfer protein Bos taurus 51-55 3120703-7 1987 It can be thus concluded that, in the release of arachidonic acid by antigen-stimulated mast cells, the phospholipase A2 pathway, in which phosphatidylcholine is hydrolysed, serves as the major one, the phospholipase C/diacylglycerol lipase pathway playing only a minor role. Phosphatidylcholines 139-158 phospholipase A2 group IB Rattus norvegicus 104-120 3651600-1 1987 The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Phosphatidylcholines 51-53 phosphatidylcholine transfer protein Bos taurus 4-49 3631062-2 1987 PLase A2-induced conversion of phosphatidyl choline (PC) to lysophosphatidyl choline (L-PC) was associated with a marked increase in Na+ influx and Ca2+ uptake. Phosphatidylcholines 31-51 phospholipase A2 group IB Homo sapiens 0-8 3681145-3 1987 Of all the examined liposomes prepared from cholesterol and various synthetic phosphatidylcholines, liposomes with dimyristoylphosphatidylcholine (DMPC) were found to be the most reactive in the LCAT reaction. Phosphatidylcholines 78-98 lecithin-cholesterol acyltransferase Homo sapiens 195-199 3620490-10 1987 The subcellular content of disaturated phosphatidylcholine (PC) appeared to correlate well with the activity of phospholipase A2 in the neonatal mitochondrial, microsomal and cytosolic fractions. Phosphatidylcholines 60-62 phospholipase A2 Oryctolagus cuniculus 112-128 3631062-2 1987 PLase A2-induced conversion of phosphatidyl choline (PC) to lysophosphatidyl choline (L-PC) was associated with a marked increase in Na+ influx and Ca2+ uptake. Phosphatidylcholines 53-55 phospholipase A2 group IB Homo sapiens 0-8 3655561-1 1987 The binding of phosphatidylcholine and cholesterol in model bile to human gallbladder mucin was studied by means of a rapid filtration binding assay and sucrose density gradient ultracentrifugation. Phosphatidylcholines 15-34 LOC100508689 Homo sapiens 86-91 3663914-2 1987 It has been shown that the repair effect of phosphatidylcholine liposomes was manifested in vivo by normalization of phospholipid membrane composition, reduction in the degree of cytochrome P-450 inactivation, partial normalization of its hydroxylase activity and recovery of glucose-6-phosphatase activity. Phosphatidylcholines 44-63 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 276-297 3655561-2 1987 Numerous low affinity binding sites for phosphatidylcholine and cholesterol were present on gallbladder mucin. Phosphatidylcholines 40-59 LOC100508689 Homo sapiens 104-109 3655561-3 1987 Binding of phosphatidylcholine and cholesterol to mucin increased as a function of cholesterol saturation index. Phosphatidylcholines 11-30 LOC100508689 Homo sapiens 50-55 3655561-5 1987 Proteolytic digestion also resulted in a 91% and 78% decrease, respectively, in the binding of phosphatidylcholine and cholesterol to mucin. Phosphatidylcholines 95-114 LOC100508689 Homo sapiens 134-139 3655561-9 1987 These data indicate that highly purified human gallbladder mucin binds phosphatidylcholine and cholesterol in model bile. Phosphatidylcholines 71-90 LOC100508689 Homo sapiens 59-64 3475216-1 1987 Prostaglandin (PG) E1 was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL3) to low density lipoproteins (LDL). Phosphatidylcholines 68-87 HDL3 Homo sapiens 149-153 2820405-2 1987 The highly purified reductase oxidized NADPH and generated superoxide when combined with partially purified cytochrome b559 in the presence of phosphatidylcholine. Phosphatidylcholines 143-162 2,4-dienoyl-CoA reductase 1 Homo sapiens 39-44 2820405-2 1987 The highly purified reductase oxidized NADPH and generated superoxide when combined with partially purified cytochrome b559 in the presence of phosphatidylcholine. Phosphatidylcholines 143-162 mitochondrially encoded cytochrome b Homo sapiens 108-120 3607074-9 1987 Experiments with exogenously added labeled phosphatidylcholines confirmed that chromaffin granule ghosts contain a phospholipase A2 activity (alkaline pH optimum). Phosphatidylcholines 43-63 LOC104974671 Bos taurus 115-131 3607054-3 1987 Reduction of membrane phosphatidylcholine by phospholipase A2 resulted in a marked increase in the binding of the entire HDL3 particle and a relative decrease in preferential binding of [3H]cholesteryl linoleyl ether. Phosphatidylcholines 22-41 LOC104974671 Bos taurus 45-61 3607054-3 1987 Reduction of membrane phosphatidylcholine by phospholipase A2 resulted in a marked increase in the binding of the entire HDL3 particle and a relative decrease in preferential binding of [3H]cholesteryl linoleyl ether. Phosphatidylcholines 22-41 HDL3 Homo sapiens 121-125 3111472-2 1987 Negatively charged lipids, sulfatide and phosphatidylserine (PS), lowered the Km values of t-PA for plasminogen activation (sulfatide, 20-fold; PS, 6-fold), whereas neutral lipid phosphatidylcholine raised the Km. Phosphatidylcholines 179-198 plasminogen activator, tissue type Homo sapiens 91-95 3597406-3 1987 All ester PCs were good acyl donors for the transesterification of cholesterol catalyzed by human lecithin-cholesterol acyltransferase except DPhPC, which showed no reactivity. Phosphatidylcholines 10-13 lecithin-cholesterol acyltransferase Homo sapiens 98-134 2959316-4 1987 The fusion of liposomes containing Fc gamma 2bR, which was obtained as phosphatidylcholine (PC) binding protein as previously described, with the cyc- membrane preparations resulted in the marked suppression of membrane adenylate cyclase, whereas the fusion of liposomes containing Fc gamma 2a, which was obtained as IgG-binding protein, led to about a 2.7-fold increase. Phosphatidylcholines 71-90 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 146-149 2959316-4 1987 The fusion of liposomes containing Fc gamma 2bR, which was obtained as phosphatidylcholine (PC) binding protein as previously described, with the cyc- membrane preparations resulted in the marked suppression of membrane adenylate cyclase, whereas the fusion of liposomes containing Fc gamma 2a, which was obtained as IgG-binding protein, led to about a 2.7-fold increase. Phosphatidylcholines 92-94 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 146-149 3593755-5 1987 Emulsions containing saturated phosphatidylcholines at temperatures below their melting points were poor substrates for lipoprotein lipase, compared with those stabilized by mixed chain phosphatidylcholines. Phosphatidylcholines 31-51 lipoprotein lipase Rattus norvegicus 120-138 3625042-0 1987 Synthesis of a naphthylvinyl-labeled glycerol ether analog of phosphatidylcholine and its use in the assay of phospholipase A2. Phosphatidylcholines 62-81 phospholipase A2 group IB Homo sapiens 110-126 2958081-5 1987 It was also found that the degradation of liposomal phosphatidylcholine by soluble snake venom PLA2 is inversely proportional to the solvent viscosity. Phosphatidylcholines 52-71 phospholipase A2 group IB Homo sapiens 95-99 3116710-5 1987 Apparently, AD6 inhibits the release of arachidonic acid from phosphatidylinositol and choline phosphoglycerides which are the main sources of the substrate for the synthesis of prostaglandins and thromboxanes. Phosphatidylcholines 87-112 AD6 Homo sapiens 12-15 3107616-0 1987 Properties of discoidal complexes of human apolipoprotein A-I with phosphatidylcholines containing various fatty acid chains. Phosphatidylcholines 67-87 apolipoprotein A1 Homo sapiens 43-61 3593706-6 1987 Polymerized DPL vesicles uniquely bound a protein of about 53 kDa which was not bound to other types of phosphatidylcholine liposomes. Phosphatidylcholines 104-123 prion like protein doppel Homo sapiens 12-15 3107616-1 1987 In this study we demonstrate that apolipoprotein A-I determined the common size classes of discoidal particles formed with numerous phosphatidylcholines, and with ether analogs of phosphatidylcholines. Phosphatidylcholines 132-152 apolipoprotein A1 Homo sapiens 34-52 3107616-1 1987 In this study we demonstrate that apolipoprotein A-I determined the common size classes of discoidal particles formed with numerous phosphatidylcholines, and with ether analogs of phosphatidylcholines. Phosphatidylcholines 180-200 apolipoprotein A1 Homo sapiens 34-52 3584136-7 1987 In incubations designed to simulate in vivo conditions, no more than 15% of the disappearance of 16:1-16:1 PC, one of the most rapidly cleared PCs, was due to the action of LCAT. Phosphatidylcholines 143-146 lecithin cholesterol acyltransferase Rattus norvegicus 173-177 3591946-8 1987 Kinetic analysis of phosphatidylcholine-stabilized triglyceride emulsions revealed a significant decrease in immobilized enzyme Km and an increase in Vmax when the emulsion was supplemented with apoE. Phosphatidylcholines 20-39 apolipoprotein E Homo sapiens 195-199 3113456-8 1987 Diacylglycerols were not highly labelled and the action of phospholipase A2 on labelled phosphatidylcholine was indicated. Phosphatidylcholines 88-107 phospholipase A2 group IB Rattus norvegicus 59-75 3038645-2 1987 Although phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine also increased insulin receptor autophosphorylation, only phosphatidylinositol (PtdIns) stimulated to a similar extent as the phospholipid mixture. Phosphatidylcholines 9-28 insulin receptor Homo sapiens 93-109 3108322-5 1987 Analysis of tissue phosphatidylcholine by mass spectrometric techniques revealed metabolism of PAF to 1-0-hexadecyl-2-arachidonoyl-GPC, which represented 20-23% of the administered radiolabeled hexadecyl-PAF. Phosphatidylcholines 19-38 PCNA clamp associated factor Rattus norvegicus 95-98 3032270-0 1987 Effects of vasopressin on the synthesis of phosphatidylethanolamines and phosphatidylcholines by isolated rat hepatocytes. Phosphatidylcholines 73-93 arginine vasopressin Rattus norvegicus 11-22 3032270-1 1987 The effect of vasopressin on the biosynthesis of phosphatidylcholines and phosphatidylethanolamines was investigated in freshly isolated rat hepatocytes in suspension. Phosphatidylcholines 49-69 arginine vasopressin Rattus norvegicus 14-25 3032270-2 1987 Treatment of hepatocytes with vasopressin inhibits the incorporation of [Me-14C]choline into phosphatidylcholines in a dose-dependent manner. Phosphatidylcholines 93-113 arginine vasopressin Rattus norvegicus 30-41 3032270-5 1987 In contrast with the inhibitory effect of vasopressin on the synthesis of phosphatidylcholines, this hormone stimulates the incorporation of [1,2-14C]ethanolamine into phosphatidylethanolamines in a dose-dependent manner. Phosphatidylcholines 74-94 arginine vasopressin Rattus norvegicus 42-53 3104321-3 1987 At pH values below about 5, TNF bound to phospholipid liposomes composed of mixtures of phosphatidyl-serine and phosphatidylcholine in molar ratios of 2:1 and 1:2 and caused rapid release of calcein. Phosphatidylcholines 112-131 tumor necrosis factor Homo sapiens 28-31 3032677-0 1987 De novo CDP-choline-dependent glycerophosphorylcholine synthesis and its involvement as an intermediate in phosphatidylcholine synthesis. Phosphatidylcholines 107-126 cut like homeobox 1 Homo sapiens 8-11 3598396-10 1987 However, the hepatic lipase of postheparin plasma had similar activity towards the two phosphatidylcholine species. Phosphatidylcholines 87-106 lipase C, hepatic type Bos taurus 13-27 3598396-12 1987 Antiserum to hepatic lipase inhibited the postheparin plasma hydrolysis of phosphatidylethanolamine and 3H-labeled phosphatidylcholine by about 60%, but the 14C-labeled phosphatidylcholine by only 27%. Phosphatidylcholines 115-134 lipase C, hepatic type Bos taurus 13-27 3032677-1 1987 The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver. Phosphatidylcholines 216-235 cut like homeobox 1 Homo sapiens 16-19 3828337-4 1987 The binding site for the sn-2 fatty acyl chain was investigated by incorporating in the transfer protein either phosphatidylinositol or phosphatidylcholine carrying a parinaroyl-chain attached at the sn-2 position. Phosphatidylcholines 136-155 solute carrier family 38 member 5 Bos taurus 25-29 3032677-1 1987 The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver. Phosphatidylcholines 216-235 cut like homeobox 1 Homo sapiens 75-78 3828337-5 1987 Time-resolved fluorescence spectroscopy revealed that the sn-2 fatty acyl chains for both phospholipids in the lipid-protein complex were completely immobilized (i.e., rotational correlation times of 17.4 ns for phosphatidylcholine and 16.3 ns for phosphatidylinositol). Phosphatidylcholines 212-231 solute carrier family 38 member 5 Bos taurus 58-62 3032300-3 1987 Phosphatidylcholine protective action is also manifested in an increase in the activity of glucose-6-phosphatase, a microsomal marker enzyme, up to its control level and in a 20% reduced rate of cytochrome P-450 inactivation. Phosphatidylcholines 0-19 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 91-112 3566802-0 1987 Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2. Phosphatidylcholines 47-66 phospholipase A2 group IB Homo sapiens 81-97 3032300-3 1987 Phosphatidylcholine protective action is also manifested in an increase in the activity of glucose-6-phosphatase, a microsomal marker enzyme, up to its control level and in a 20% reduced rate of cytochrome P-450 inactivation. Phosphatidylcholines 0-19 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 195-211 3829397-1 1987 Phospholipase A (PLA) activity was measured with a semi-automated photometric test system that is based on liberation of fatty acids from phosphatidylcholine by phospholipases A1 (EC 3.1.1.32) and A2 (EC 3.1.1.4). Phosphatidylcholines 138-157 phospholipase A and acyltransferase 1 Homo sapiens 0-15 3829397-1 1987 Phospholipase A (PLA) activity was measured with a semi-automated photometric test system that is based on liberation of fatty acids from phosphatidylcholine by phospholipases A1 (EC 3.1.1.32) and A2 (EC 3.1.1.4). Phosphatidylcholines 138-157 phospholipase A and acyltransferase 1 Homo sapiens 17-20 3559272-4 1987 The activities of both phospholipase A2 and C were assayed in each sample using phosphatidylcholine and phosphatidylinositol, respectively, as substrates. Phosphatidylcholines 80-99 phospholipase A2 group IB Homo sapiens 23-39 3549256-7 1987 On the other hand, as reported previously, insulin and cortisol, in combination, stimulated phosphatidylcholine synthesis. Phosphatidylcholines 92-111 insulin Homo sapiens 43-50 3112131-4 1987 The loss of [3H]arachidonate radioactivity from phosphatidylcholine was almost equivalent to the increase in released [3H]arachidonic acid, suggesting the hydrolysis of phosphatidylcholine by phospholipase A2. Phosphatidylcholines 169-188 phospholipase A2 group IB Homo sapiens 192-208 3104334-0 1987 Reaction of discoidal complexes of apolipoprotein A-I and various phosphatidylcholines with lecithin cholesterol acyltransferase. Phosphatidylcholines 66-86 lecithin-cholesterol acyltransferase Homo sapiens 92-128 2437135-4 1987 The detergent-extracted HABP from SV-3T3 membranes was reconstituted into the membrane of lipid vesicles, which were formed by addition of exogenous phosphatidylcholine and cholic acid to the extracts followed by removal of detergent by dialysis against 0.02 M Tris pH 8.0 in the presence of protease inhibitors. Phosphatidylcholines 149-168 hyaluronic acid binding protein 2 Mus musculus 24-28 3549734-3 1987 This stimulatory protein was stable for several months when frozen at -70 degrees C. The purified protein selectively stimulated phospholipase A2 when phosphatidylcholine was used as a substrate but had no effect on phospholipase A2 activity when phosphatidylethanolamine was used as a substrate. Phosphatidylcholines 151-170 phospholipase A2 group IB Homo sapiens 129-145 3545832-5 1987 The interaction of the side chains of Trp1 and Trp3 residues of alpha-mating factor with the hydrophobic interior of the bilayer contributes to the binding of this peptide with the phosphatidylcholine bilayer. Phosphatidylcholines 181-200 phosphoribosylanthranilate isomerase TRP1 Saccharomyces cerevisiae S288C 38-42 3545832-5 1987 The interaction of the side chains of Trp1 and Trp3 residues of alpha-mating factor with the hydrophobic interior of the bilayer contributes to the binding of this peptide with the phosphatidylcholine bilayer. Phosphatidylcholines 181-200 bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase Saccharomyces cerevisiae S288C 47-51 3545832-6 1987 The conformation of des-Trp1-alpha-mating-factor [(2-13)peptide] in the membrane-bound state has been found to be similar to that of (1-13)peptide from the analysis of transferred nuclear Overhauser effects in the presence of mixed vesicles of perdeuterated phosphatidylcholine and perdeuterated phosphatidylserine. Phosphatidylcholines 258-277 phosphoribosylanthranilate isomerase TRP1 Saccharomyces cerevisiae S288C 24-28 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 237-256 gastrin releasing peptide Homo sapiens 129-137 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 258-260 gastrin releasing peptide Homo sapiens 0-8 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 258-260 gastrin releasing peptide Homo sapiens 129-137 3558493-1 1987 Stimulation was blocked by the bombesin receptor antagonist, [D-Arg1, D-Pro2, D-Trp7,9, Leu11] substance P, indicating that the effects on both PI and PC were mediated through the same receptor. Phosphatidylcholines 151-153 gastrin releasing peptide Homo sapiens 31-39 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 37-56 gastrin releasing peptide Homo sapiens 0-8 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 37-56 gastrin releasing peptide Homo sapiens 129-137 3558493-0 1987 Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min. Phosphatidylcholines 237-256 gastrin releasing peptide Homo sapiens 0-8 3801511-5 1987 Whereas the snake venom phospholipase A2 preferred phosphatidylcholine as a substrate, the other phospholipases A2 preferred acidic phospholipids in the order monomethylester greater than or equal to glycerol greater than or equal to serine. Phosphatidylcholines 51-70 LOC104974671 Bos taurus 24-40 3099849-5 1987 Parallel to the liberation process, phosphatidylcholine underwent a rapid decrease of radioactivity with both agonists, suggesting the involvement of a Ca2+-dependent phospholipase A2. Phosphatidylcholines 36-55 phospholipase A2 group V Homo sapiens 152-183 3029085-4 1987 The two cholinephosphotransferases that catalyze the biosynthesis of phosphatidylcholine and PAF have similar Mg2+ or Mn2+ requirements and are inhibited by Ca2+. Phosphatidylcholines 69-88 PCNA clamp associated factor Rattus norvegicus 93-96 3104714-7 1987 Thus, HPLC methodology indicates that arachidonoyl-containing molecular species of phosphatidylcholine and phosphatidylethanolamine are the major source of arachidonic acid in thrombin-stimulated human platelets, while certain ether phospholipid molecular species become enriched in arachidonate. Phosphatidylcholines 83-102 coagulation factor II, thrombin Homo sapiens 176-184 3102469-4 1987 At high Ca2+ concentrations, phosphatidylcholine and diacylphosphatidylethanolamine were hydrolyzed after stimulation with collagen, and phosphatidylserine and alkenylacylphosphatidylethanolamine were degraded after stimulation with both thrombin and collagen. Phosphatidylcholines 29-48 coagulation factor II, thrombin Homo sapiens 238-246 3818590-6 1987 In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome. Phosphatidylcholines 233-252 AT695_RS01930 Staphylococcus aureus 26-31 3818590-6 1987 In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome. Phosphatidylcholines 233-252 AT695_RS01930 Staphylococcus aureus 172-177 3818596-3 1987 In the final purification step, partially purified CETP is incubated with a synthetic lipid emulsion consisting of phosphatidylcholine, triglyceride, and fatty acid, and the bound activity, which elutes in the void volume, is separated from nonbound proteins by gel filtration on Sepharose 4B. Phosphatidylcholines 115-134 cholesteryl ester transfer protein Homo sapiens 51-55 3828111-8 1987 The results suggest the possibility that changes in the levels of liver CTP may play a role in regulation of the cytidine pathway of liver phosphatidylcholine synthesis but not of phosphatidylethanolamine synthesis, because the latter pathway appears to be tightly controlled at the ethanolaminephosphotransferase step. Phosphatidylcholines 139-158 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 72-75 3029069-2 1987 Thrombomodulin was incorporated into vesicles ranging from neutral (100% phosphatidylcholine) to highly charged (30% phosphatidylserine and 70% phosphatidylcholine). Phosphatidylcholines 73-92 thrombomodulin Oryctolagus cuniculus 0-14 3029069-2 1987 Thrombomodulin was incorporated into vesicles ranging from neutral (100% phosphatidylcholine) to highly charged (30% phosphatidylserine and 70% phosphatidylcholine). Phosphatidylcholines 144-163 thrombomodulin Oryctolagus cuniculus 0-14 3029069-4 1987 Incorporation of thrombomodulin into phosphatidylcholine, with or without phosphatidylserine, alters the Ca2+ concentration dependence of protein C activation. Phosphatidylcholines 37-56 thrombomodulin Oryctolagus cuniculus 17-31 3029069-8 1987 Incorporation of thrombomodulin into pure phosphatidylcholine vesicles reduces the Km for protein C from 7.6 +/- 2 to 0.7 +/- 0.2 microM. Phosphatidylcholines 42-61 thrombomodulin Oryctolagus cuniculus 17-31 3029069-11 1987 The Km for protein C observed on endothelial cells is more similar to the Km observed when thrombomodulin (TM) is incorporated into pure phosphatidylcholine vesicles than into negatively charged vesicles, suggesting that the protein C-binding site on endothelial cells does not involve negatively charged phospholipids. Phosphatidylcholines 137-156 thrombomodulin Oryctolagus cuniculus 91-105 3107565-4 1987 When washed human platelets were stimulated by thrombin or A23187, the amount of PEP monitored by optical density was significantly decreased in consort with phosphatidylcholine (PC), indicating an active participation of PEP in the liberation of AA. Phosphatidylcholines 158-177 coagulation factor II, thrombin Homo sapiens 47-55 3107565-4 1987 When washed human platelets were stimulated by thrombin or A23187, the amount of PEP monitored by optical density was significantly decreased in consort with phosphatidylcholine (PC), indicating an active participation of PEP in the liberation of AA. Phosphatidylcholines 179-181 coagulation factor II, thrombin Homo sapiens 47-55 3572249-0 1987 Relation of lung fatty acid binding protein to the biosynthesis of pulmonary phosphatidic acid and phosphatidylcholine. Phosphatidylcholines 99-118 glutamic-oxaloacetic transaminase 2 Homo sapiens 17-43 3024736-4 1987 Angiotensin II also decreased the 3H radioactivity of PIP slightly only at 15 s and increased that of phosphatidic acid after 15 s, with no significant effect upon the labelings of phosphatidylinositol (PI), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) within 1 min. Phosphatidylcholines 229-231 angiotensinogen Rattus norvegicus 0-14 3801467-1 1987 The localization of the effects of DDT (5-50 mol%) addition on the acyl chain dynamics in unilamellar vesicles of two phosphatidylcholines (DPPC and egg PC) has been investigated by steady-state fluorescence polarization of a series of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12 and 16) whose fluorophore is located at a graded series of depths from the surface to the centre of the bilayer. Phosphatidylcholines 118-138 D-dopachrome tautomerase Homo sapiens 35-38 3805022-2 1987 The hydrophobicity of ligatin is also reflected by its ability to interpolate into the phosphatidylcholine bilayer as shown by a concentration-dependent change in membrane conductance. Phosphatidylcholines 87-106 ligatin Homo sapiens 22-29 3790605-1 1987 Evidence is provided in this paper to indicate that hydrolysis of exogenously added phosphatidylethanolamine and phosphatidylcholine by the membrane-bound phospholipase A2 from rat-liver mitochondria is preceded by association of the substrates with the membranes. Phosphatidylcholines 113-132 phospholipase A2 group IB Rattus norvegicus 155-171 3793726-5 1987 First-order decreases in cholesterol esterase activity effected by compound 1 or 2 are also observed in the presence of taurocholate/phosphatidylcholine micelles. Phosphatidylcholines 133-152 carboxyl ester lipase Homo sapiens 25-45 3025201-1 1987 Light stimulates phospholipase A2 activity in rod outer segments (ROS) of bovine retina as measured by the liberation of arachidonate from phosphatidylcholine, in in vitro assays of dark-adapted ROS. Phosphatidylcholines 139-158 LOC104974671 Bos taurus 17-33 20501174-9 1987 Since both of these compounds are used in the biosynthesis of phosphatidylcholine, both may be involved in the long-term effects of the CDP-choline. Phosphatidylcholines 62-81 cut-like homeobox 1 Rattus norvegicus 136-139 3032160-2 1987 This enhanced synthesis of phosphatidylcholine was accompanied by an increased conversion of choline phosphate into CDP-choline. Phosphatidylcholines 27-46 cut-like homeobox 1 Rattus norvegicus 116-119 3028505-1 1987 Temperature relationship was measured of ESR spectra of spin probes--derivatives of fatty acids whose nitroxyl fragments are incorporated into surface and inner layers of phosphatidylcholine liposomes (T = 180-260 K), as well as of the probe in model ethanol solution (T = 110-220 K). Phosphatidylcholines 171-190 spindlin 1 Homo sapiens 56-60 3593300-3 1987 Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC). Phosphatidylcholines 191-210 phospholipase A2 group IB Homo sapiens 51-67 3593300-3 1987 Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC). Phosphatidylcholines 212-214 phospholipase A2 group IB Homo sapiens 51-67 2963203-2 1987 The SR protein is solubilized with the zwitterionic detergent CHAPS in the presence of added 5-mM phosphatidylcholine and 20% glycerol, which stabilize the reconstitutable Ca2+ transport activity. Phosphatidylcholines 98-117 RNA binding protein with serine rich domain 1 Homo sapiens 4-14 3039692-4 1987 On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine. Phosphatidylcholines 31-50 proenkephalin Rattus norvegicus 106-116 16665217-1 1987 Evidence for the involvement of Ca(2+) and calmodulin in the regulation of phospholipid breakdown by microsomal membranes from bean cotyledons has been obtained by following the formation of radiolabeled degradation products from [U-(14)C]phosphatidylcholine. Phosphatidylcholines 239-258 calmodulin 1 Homo sapiens 43-53 3039692-4 1987 On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine. Phosphatidylcholines 186-205 proenkephalin Rattus norvegicus 106-116 3039692-4 1987 On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine. Phosphatidylcholines 186-205 proenkephalin Rattus norvegicus 106-116 3535899-9 1986 These findings indicate that the insulin secretagogue D-glucose induces phospholipid hydrolysis in islets and suggest that PC may be the major source of free arachidonate which accumulates in glucose-stimulated islets. Phosphatidylcholines 123-125 insulin Homo sapiens 33-40 2947479-9 1986 The inhibition of Na+-Ca2+ exchange caused by phospholipase A2 digestion in the control heart sarcolemma was completely reversible by the addition of phosphatidylcholine (0.1 mM). Phosphatidylcholines 150-169 phospholipase A2 group IB Canis lupus familiaris 46-62 2948560-1 1986 The ATPase activity of the (Ca2+-Mg2+)-ATPase reconstituted into bilayers of phosphatidylcholines depends on the fatty acyl chain length of the phospholipids. Phosphatidylcholines 77-97 dynein axonemal heavy chain 8 Homo sapiens 4-10 3032217-0 1986 The relative degradation of [14C]eicosapentaenoyl and [3H]arachidonoyl species of phosphatidylinositol and phosphatidylcholine in thrombin-stimulated human platelets. Phosphatidylcholines 107-126 coagulation factor II, thrombin Homo sapiens 130-138 3032217-4 1986 The [3H]AA/[14C]EPA dpm ratio for the loss of radioactivity from phosphatidylcholine (PC) upon thrombin stimulation, as well as that in the residual PC remaining after stimulation, was similar to that in PC in the resting platelets. Phosphatidylcholines 86-88 coagulation factor II, thrombin Homo sapiens 95-103 2948560-1 1986 The ATPase activity of the (Ca2+-Mg2+)-ATPase reconstituted into bilayers of phosphatidylcholines depends on the fatty acyl chain length of the phospholipids. Phosphatidylcholines 77-97 dynein axonemal heavy chain 8 Homo sapiens 39-45 3801440-5 1986 However, binding of C5b-6 to membranes required phosphatidylglycerol or phosphatidic acid produced from egg phosphatidylcholine while binding of C5b-6 to phosphatidylcholine, phosphatidylserine, or phosphatidylinositol was undetectable. Phosphatidylcholines 108-127 complement C5 Homo sapiens 20-23 3778900-3 1986 From all substances tested (isoproterenol, phenylephrine, adrenalin, histamine, angiotensin II, dansylcadaverine, propranolol) only isoproterenol and adrenalin slightly decreased total amount of phosphatidylcholine (PC). Phosphatidylcholines 195-214 angiotensinogen Homo sapiens 80-94 3096314-0 1986 Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phospholipase C in mammalian cells. Phosphatidylcholines 73-92 LOC100009319 Oryctolagus cuniculus 39-54 3562319-6 1986 CD reveals that BK also interacts with acidic lipids which bear a net electrical charge (e.g., cerebroside sulfate and phosphatidyl inositol) but not with lipids bearing no net charge (e.g., cerebroside and phosphatidyl choline). Phosphatidylcholines 207-227 kininogen 1 Homo sapiens 16-18 3768366-0 1986 The intramembranous domains of lipophilin in phosphatidylcholine vesicles are similar to those in the myelin membrane. Phosphatidylcholines 45-64 proteolipid protein 1 Homo sapiens 31-41 2433381-1 1986 A photometric method for the determination of phospholipase A is described, in which fatty acids are liberated from phosphatidylcholine and measured by a discontinuous enzymatic test. Phosphatidylcholines 116-135 phospholipase A and acyltransferase 1 Homo sapiens 46-61 2434471-3 1986 Purified PLA2 had absolute 2-acyl specificity, and hydrolyzed phosphatidylcholine with optimal activity at pH 7.5-8.0 and phosphatidylethanolamine with optimal activity at pH 7.0. Phosphatidylcholines 62-81 phospholipase A2 group IB Homo sapiens 9-13 3768409-4 1986 The prothrombinase activity of resting, non-activated platelets, lysed platelets and vesicles composed of phosphatidylserine and phosphatidylcholine at different molar ratios is inhibited by beta 2-glycoprotein-I in a dose-dependent manner. Phosphatidylcholines 129-148 coagulation factor X Homo sapiens 4-18 3790533-7 1986 Lysosomal phospholipase A from rat kidney hydrolyzes the sn-1 acyl group of phosphatidylcholine, does not require divalent cations for full activity, and is not inhibited by ethylenediaminetetraacetic acid. Phosphatidylcholines 76-95 phospholipase A and acyltransferase 1 Rattus norvegicus 10-25 3096314-0 1986 Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phospholipase C in mammalian cells. Phosphatidylcholines 73-92 LOC100009319 Oryctolagus cuniculus 104-119 3756214-1 1986 The phosphatidylcholine (PC) component of liposomes was structurally modified by replacing its C-1, or both C-1 and C-2, ester linkage(s) with an ether and/or carbamyl bond(s) or by changing its steric configuration. Phosphatidylcholines 4-23 complement C2 Rattus norvegicus 116-119 3756205-0 1986 Fatty acyl chain specificity of phosphatidylcholine hydrolysis catalyzed by lipoprotein lipase. Phosphatidylcholines 32-51 lipoprotein lipase Homo sapiens 76-94 3756205-9 1986 These data are consistent with a model for activation of lipoprotein lipase in which residues 56-79 bind to lipoprotein lipase and alter the interaction of the sn-2 acyl chain of the phosphatidylcholine (PC) substrate or the lysoPC product within the activated state complex. Phosphatidylcholines 183-202 lipoprotein lipase Homo sapiens 57-75 3756205-9 1986 These data are consistent with a model for activation of lipoprotein lipase in which residues 56-79 bind to lipoprotein lipase and alter the interaction of the sn-2 acyl chain of the phosphatidylcholine (PC) substrate or the lysoPC product within the activated state complex. Phosphatidylcholines 204-206 lipoprotein lipase Homo sapiens 57-75 3531198-8 1986 In the presence of 50 microM phospholipid vesicles (25% phosphatidylserine/75% phosphatidylcholine; mole/mole), the Km is 0.34 microM and the Vmax is 7.1 mumol of prothrombin activated per min/mg of venom. Phosphatidylcholines 79-98 coagulation factor II, thrombin Bos taurus 163-174 3756214-1 1986 The phosphatidylcholine (PC) component of liposomes was structurally modified by replacing its C-1, or both C-1 and C-2, ester linkage(s) with an ether and/or carbamyl bond(s) or by changing its steric configuration. Phosphatidylcholines 25-27 complement C2 Rattus norvegicus 116-119 3815624-0 1986 Pr3+ transport across phosphatidylcholine vesicles mediated by open crown synthetic ionophores. Phosphatidylcholines 22-41 proteinase 3 Homo sapiens 0-3 3815624-1 1986 Pr3+ transport experiments, varying temperature and concentration, show that open crown synthetic polyethers (podands) mediate Pr3+ translocation across phosphatidylcholine vesicles by a carrier mechanism. Phosphatidylcholines 153-172 proteinase 3 Homo sapiens 0-3 3815624-1 1986 Pr3+ transport experiments, varying temperature and concentration, show that open crown synthetic polyethers (podands) mediate Pr3+ translocation across phosphatidylcholine vesicles by a carrier mechanism. Phosphatidylcholines 153-172 proteinase 3 Homo sapiens 127-130 3741864-2 1986 Cytochrome b5 becomes firmly bound to the membrane and at the same time lysophosphatidylcholine is acylated by acyltransferases of the endoplasmic reticulum and converted into the membrane component phosphatidylcholine. Phosphatidylcholines 76-95 cytochrome b5 type A Homo sapiens 0-13 2943317-1 1986 The (Ca2+ + Mg2+)-ATPase purified from rabbit muscle sarcoplasmic reticulum has been reconstituted into a series of phosphatidylcholines in the liquid crystalline phase. Phosphatidylcholines 116-136 plasma membrane calcium-transporting ATPase 1 Oryctolagus cuniculus 5-24 3026352-4 1986 Experiments using double (3H/14C) labelling, to distinguish pools with different rates of turnover, suggest the major pool of arachidonic acid used for synthesis of lipoxygenase metabolites turns over more slowly than arachidonic acid in diacylglycerol, but at about the same rate as arachidonic acid esterified in phosphatidylcholine or phosphatidylinositol. Phosphatidylcholines 315-334 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 165-177 3781738-3 1986 The binding of tritiated Leu-enkephalin to phosphatidylserine and phosphatidylcholine vesicles, both unmodified and modified by the incorporation of free fatty acid, has been studied by steric exclusion chromatography, ultraviolet difference spectroscopy and fluorescence anisotropy. Phosphatidylcholines 66-85 prodynorphin Homo sapiens 25-39 3020142-5 1986 Angiotensin II (0.25 nmol/l to 0.25 mumol/l) highly significantly (P less than 0.01) stimulated aldosterone and corticosterone outputs, [32P] incorporation into phosphatidic acid and phosphatidylinositol (but not into phosphatidylcholine) and the production of the three [3H]inositol phosphates. Phosphatidylcholines 218-237 angiotensinogen Rattus norvegicus 0-14 3026338-3 1986 Reconstitution of thrombomodulin into phospholipid vesicles containing anionic phospholipids resulted in an increased rate of activation of protein C. Cardiolipin and vesicles containing phosphatidylcholine/phosphatidylserine (1:1, w/w) were the most effective. Phosphatidylcholines 187-206 thrombomodulin Homo sapiens 18-32 3094578-3 1986 This paper addresses the validity of this assumption on the basis of the examination of the state of self-association and binding properties with egg yolk phosphatidylcholine small unilamellar vesicles of native and iodinated apolipoprotein A-I (apoA-I). Phosphatidylcholines 155-174 apolipoprotein A1 Homo sapiens 246-252 3015212-1 1986 Gastric (H+ + K+)-ATPase was reconstituted into artificial phosphatidylcholine/cholesterol liposomes by means of a freeze-thaw-sonication technique. Phosphatidylcholines 59-78 dynein axonemal heavy chain 8 Homo sapiens 18-24 3733728-3 1986 Leukotriene D4 treatment resulted in a dose-dependent, stereospecific increase in phospholipase A2 activity with phosphatidylcholine as a substrate. Phosphatidylcholines 113-132 phospholipase A2, group IB, pancreas Mus musculus 82-98 3089288-2 1986 Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate. Phosphatidylcholines 126-145 LOC104974671 Bos taurus 26-42 3021886-2 1986 Fifteen seconds following thrombin addition (15 U/5 X 10(9) platelets), phosphatidylcholine lost 11.8 nmol of arachidonate and phosphatidylethanolamine lost 10.5 nmol. Phosphatidylcholines 72-91 coagulation factor II, thrombin Homo sapiens 26-34 3730428-0 1986 Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed. Phosphatidylcholines 209-228 phospholipase A2 group IB Homo sapiens 55-71 3730428-0 1986 Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed. Phosphatidylcholines 209-228 phospholipase A2 group IB Homo sapiens 78-94 3730428-0 1986 Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed. Phosphatidylcholines 230-232 phospholipase A2 group IB Homo sapiens 55-71 3730428-0 1986 Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed. Phosphatidylcholines 230-232 phospholipase A2 group IB Homo sapiens 78-94 3089288-2 1986 Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate. Phosphatidylcholines 147-149 LOC104974671 Bos taurus 26-42 3759928-5 1986 The partially purified cytochrome P-450 efficiently catalyzed the omega-hydroxylation of various prostaglandins such as PGE1, PGE2, PGF2 alpha, PGD2, and PGA1 in a reconstituted system containing NADPH-cytochrome P-450 reductase, cytochrome b5, and phosphatidylcholine. Phosphatidylcholines 249-268 cytochrome P-450 Oryctolagus cuniculus 23-39 3718986-6 1986 In cells pre-treated with NaNO2 to convert hemoglobin to methemoglobin, t-butyl hydroperoxide reduces [9,10-3H]oleic acid incorporation into phosphatidylcholine by erythrocytes but does not stimulate [9,10-3H]oleic acid incorporation into phosphatidylethanolamine. Phosphatidylcholines 141-160 hemoglobin subunit gamma 2 Homo sapiens 57-70 3756002-0 1986 The supply of both CDP-choline and diacylglycerol can regulate the rate of phosphatidylcholine synthesis in HeLa cells. Phosphatidylcholines 75-94 cut like homeobox 1 Homo sapiens 19-22 3756002-1 1986 The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was measured in HeLa cells permeabilized with 0.125 mg digitonin/mL. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 33-36 3756002-2 1986 The rate of phosphatidylcholine formation was influenced by the concentration of CDP-choline in the medium. Phosphatidylcholines 12-31 cut like homeobox 1 Homo sapiens 81-84 3756002-6 1986 The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was stimulated by the supply of diacylglycerol in both HeLa cells and isolated microsomes. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 33-36 3756002-11 1986 Furthermore, incubation of microsomes with [3H]diacylglycerol and [14C]CDP-choline showed that both of the substrates were incorporated into phosphatidylcholine at the same rate. Phosphatidylcholines 141-160 cut like homeobox 1 Homo sapiens 71-74 3756002-13 1986 These results suggest that both in the permeabilized cells and in isolated membranes, the biosynthesis of phosphatidylcholine can be limited by both CDP-choline and diacylglycerol. Phosphatidylcholines 106-125 cut like homeobox 1 Homo sapiens 149-152 3758663-1 1986 Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC). Phosphatidylcholines 234-254 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 89-94 3487640-5 1986 [3H]CsA bound only nonspecifically to phosphatidylcholine:cholesterol liposomes. Phosphatidylcholines 38-57 heat shock protein 9 Mus musculus 4-7 3729948-1 1986 The effect of apolipoprotein C-II (apoC-II) and a synthetic fragment of apoC-II corresponding to residues 56-79 on the lipoprotein lipase (LpL) catalyzed hydrolysis of trioleoylglycerol in a monolayer of egg phosphatidylcholine and of dipalmitoylphosphatidylcholine vesicles was examined. Phosphatidylcholines 208-227 lipoprotein lipase Homo sapiens 119-137 3729948-1 1986 The effect of apolipoprotein C-II (apoC-II) and a synthetic fragment of apoC-II corresponding to residues 56-79 on the lipoprotein lipase (LpL) catalyzed hydrolysis of trioleoylglycerol in a monolayer of egg phosphatidylcholine and of dipalmitoylphosphatidylcholine vesicles was examined. Phosphatidylcholines 208-227 lipoprotein lipase Homo sapiens 139-142 3087773-2 1986 In addition, phospholipase A2 activity was measured directly with two different substrates, phosphatidylcholine and labelled E. coli. Phosphatidylcholines 92-111 phospholipase A2 group IB Rattus norvegicus 13-29 3758663-1 1986 Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC). Phosphatidylcholines 256-258 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 89-94 3707951-3 1986 All of the PE-PC systems examined, which contained saturated or trans-unsaturated PC components, showed limited solid-phase miscibility, chiefly because the PC component can adopt more solid phases than the PE component. Phosphatidylcholines 82-84 peptidase C Homo sapiens 11-16 3487067-2 1986 We have examined the effects of this growth factor on the biochemical development of explants of fetal rat lung, cultured in serum-free medium for 48 h. EGF enhanced the rate of choline incorporation into phosphatidylcholine and disaturated phosphatidylcholine in a dose dependent fashion. Phosphatidylcholines 205-224 epidermal growth factor like 1 Rattus norvegicus 153-156 3700412-0 1986 Fluorescence quenching of cytochrome b5 in vesicles with an asymmetric transbilayer distribution of brominated phosphatidylcholine. Phosphatidylcholines 111-130 cytochrome b5 type A Homo sapiens 26-39 3085719-0 1986 Anion effects on the reaction of lecithin-cholesterol acyltransferase with discoidal complexes of phosphatidylcholines . Phosphatidylcholines 98-118 lecithin-cholesterol acyltransferase Homo sapiens 33-69 3707601-1 1986 Purified mouse liver cytochrome P-450 reconstituted with purified NADPH-cytochrome P-450 reductase and phosphatidylcholine metabolized diethylphenylphosphine to diethylphenylphosphine oxide. Phosphatidylcholines 103-122 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 21-37 3957904-2 1986 In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine). Phosphatidylcholines 10-29 cut-like homeobox 1 Rattus norvegicus 50-53 3699017-2 1986 Human gastric lipase (HGL) activity on tributyrin emulsion was detected only in the presence of amphiphiles such as bile salts, proteins (serum albumin, beta-lactoglobulin or ovalbumin) or phosphatidylcholine. Phosphatidylcholines 189-208 lipase F, gastric type Homo sapiens 6-20 3699017-2 1986 Human gastric lipase (HGL) activity on tributyrin emulsion was detected only in the presence of amphiphiles such as bile salts, proteins (serum albumin, beta-lactoglobulin or ovalbumin) or phosphatidylcholine. Phosphatidylcholines 189-208 lipase F, gastric type Homo sapiens 22-25 3707893-7 1986 There is a loss of about 20% of the intensity of the N(CH3)3 resonance from phosphatidylcholine and sphingomyelin molecules in the LDL spectrum; this is attributed to the presence of apolipoprotein B in the surface of LDL particles, which may immobilize some of the phospholipid polar groups. Phosphatidylcholines 76-95 apolipoprotein B Homo sapiens 183-199 3957904-2 1986 In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine). Phosphatidylcholines 10-29 cut-like homeobox 1 Rattus norvegicus 211-214 3949783-3 1986 In a preliminary report we showed that the distribution of cytochrome b5 among a heterogeneous population of small sonicated phosphatidylcholine vesicles (212 to about 350 A in diameter) lies in favor of the smallest vesicles by a factor of at least 20 (Greenhut, S.F. Phosphatidylcholines 125-144 cytochrome b5 type A Homo sapiens 59-72 3718526-1 1986 Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators. Phosphatidylcholines 9-28 3-hydroxybutyrate dehydrogenase 1 Bos taurus 121-155 3718526-1 1986 Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators. Phosphatidylcholines 9-28 3-hydroxybutyrate dehydrogenase 1 Bos taurus 157-160 3718526-1 1986 Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators. Phosphatidylcholines 30-32 3-hydroxybutyrate dehydrogenase 1 Bos taurus 121-155 3718526-1 1986 Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators. Phosphatidylcholines 30-32 3-hydroxybutyrate dehydrogenase 1 Bos taurus 157-160 3718526-4 1986 When different phospholipid mixtures containing PC were used to activate apo-BDH, and the reconstituted samples were subjected to cross-linking and SDS-gel electrophoresis, a direct relationship was found between the activating effect of the phospholipids used and BDH monomer concentration in the gels. Phosphatidylcholines 48-50 3-hydroxybutyrate dehydrogenase 1 Bos taurus 77-80 3718526-4 1986 When different phospholipid mixtures containing PC were used to activate apo-BDH, and the reconstituted samples were subjected to cross-linking and SDS-gel electrophoresis, a direct relationship was found between the activating effect of the phospholipids used and BDH monomer concentration in the gels. Phosphatidylcholines 48-50 3-hydroxybutyrate dehydrogenase 1 Bos taurus 265-268 3718526-7 1986 In addition to PC, which is required by BDH, other types of phospholipids play a role in activation of purified apo-BDH, possibly via enzyme disaggregation. Phosphatidylcholines 15-17 3-hydroxybutyrate dehydrogenase 1 Bos taurus 40-43 3719068-0 1986 X-ray diffraction analysis of cytochrome b5 reconstituted in egg phosphatidylcholine vesicles. Phosphatidylcholines 65-84 cytochrome b5 type A Homo sapiens 30-43 3719068-1 1986 Cytochrome b5 was reconstituted asymmetrically into large unilamellar egg phosphatidylcholine vesicles. Phosphatidylcholines 74-93 cytochrome b5 type A Homo sapiens 0-13 3964663-2 1986 Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine. Phosphatidylcholines 206-225 lipase C, hepatic type Homo sapiens 25-55 3964657-4 1986 Ca2+-induced fusion of phosphatidylserine vesicles served to test the method and was shown to have an exponential half-time of 7 s. Phase separation (between the phosphatidylserine head groups of bulk lipid and the phosphatidylcholine head groups of the probe) was monitored by DPHpPC under the same conditions used to follow lipid mixing due to fusion. Phosphatidylcholines 215-234 carbonic anhydrase 2 Homo sapiens 0-3 3964311-4 1986 Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates. Phosphatidylcholines 64-83 phospholipase A2 group IB Homo sapiens 9-13 3949762-1 1986 Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn). Phosphatidylcholines 245-264 phospholipase A2 group IIA Homo sapiens 49-53 3949762-1 1986 Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn). Phosphatidylcholines 266-272 phospholipase A2 group IIA Homo sapiens 49-53 3964663-2 1986 Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine. Phosphatidylcholines 206-225 lipase C, hepatic type Homo sapiens 57-62 3964663-2 1986 Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine. Phosphatidylcholines 206-225 lipoprotein lipase Homo sapiens 88-91 3964311-4 1986 Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates. Phosphatidylcholines 85-87 phospholipase A2 group IB Homo sapiens 9-13 3511973-6 1986 Insulin also stimulated the incorporation of choline and glucose into phosphatidylcholine and disaturated phosphatidylcholine. Phosphatidylcholines 70-89 insulin Oryctolagus cuniculus 0-7 3947653-1 1986 When 600 X g supernatants of 10% (w/v) rat lung homogenates were incubated with CDP[Me-14C]choline both saturated and unsaturated species of phosphatidylcholine were formed from endogenous diacylglycerols. Phosphatidylcholines 141-160 cut-like homeobox 1 Rattus norvegicus 80-83 3754566-5 1986 The content of phosphatidylcholine (PC) and dipalmitoylphosphatidylcholine (DPPC) after treatment with PRL was demonstrated to be significantly higher than the control. Phosphatidylcholines 15-34 prolactin Rattus norvegicus 103-106 3754566-5 1986 The content of phosphatidylcholine (PC) and dipalmitoylphosphatidylcholine (DPPC) after treatment with PRL was demonstrated to be significantly higher than the control. Phosphatidylcholines 36-38 prolactin Rattus norvegicus 103-106 3004591-5 1986 Treatment of the phosphatidylcholine fraction with phospholipase A2 released 64% of the 5-[3H]HETE with 26% remaining in the lysophosphatidylcholine fraction. Phosphatidylcholines 17-36 phospholipase A2 group IB Homo sapiens 51-67 3081034-0 1986 Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. Phosphatidylcholines 60-79 solute carrier family 38, member 5 Rattus norvegicus 38-42 3942760-5 1986 (2) The lecithin: cholesterol acyltransferase reactivity of HDL3, containing different amounts of phosphatidylcholine, as achieved by various degrees of phospholipase A2 treatment, was measured using a crude preparation of lecithin: cholesterol acyltransferase (the d 1.21-1.25 g/ml plasma fraction). Phosphatidylcholines 98-117 lecithin-cholesterol acyltransferase Homo sapiens 8-45 3002473-0 1986 Effects of chlorpromazine and other calmodulin antagonists on phosphatidylcholine-induced vesiculation of platelet plasma membranes. Phosphatidylcholines 62-81 calmodulin 1 Homo sapiens 36-46 3942763-1 1986 The effect of apolipoproteins C-II and C-III on the lipoprotein lipase-catalyzed hydrolysis of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and particles of trioleoylglycerol stabilized with a phosphatidylcholine monolayer was investigated. Phosphatidylcholines 212-231 lipoprotein lipase Homo sapiens 52-70 3942760-5 1986 (2) The lecithin: cholesterol acyltransferase reactivity of HDL3, containing different amounts of phosphatidylcholine, as achieved by various degrees of phospholipase A2 treatment, was measured using a crude preparation of lecithin: cholesterol acyltransferase (the d 1.21-1.25 g/ml plasma fraction). Phosphatidylcholines 98-117 HDL3 Homo sapiens 60-64 3942763-1 1986 The effect of apolipoproteins C-II and C-III on the lipoprotein lipase-catalyzed hydrolysis of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and particles of trioleoylglycerol stabilized with a phosphatidylcholine monolayer was investigated. Phosphatidylcholines 212-231 apolipoprotein C2 Homo sapiens 95-114 3944128-1 1986 Cytochrome P-450 (P-450C21), purified from bovine adrenocortical microsomes, was incorporated into the single bilayer liposomes of egg yolk phosphatidylcholine by gel filtration, using a high pressure liquid chromatography system. Phosphatidylcholines 140-159 steroid 21-hydroxylase Bos taurus 18-26 3944128-3 1986 The apparent dissociation constant of the P-450C21-substrate complex increased with phosphatidylcholine concentration in the system, showing the substrate to be partitioned between the aqueous and lipid phases. Phosphatidylcholines 84-103 steroid 21-hydroxylase Bos taurus 42-50 3942762-1 1986 The triacylglycerol hydrolyase and phospholipase A1 activities of bovine milk lipoprotein lipase toward long-chain fatty acyl ester substrates were investigated with monomolecular lipid films containing trioleoylglycerol and phosphatidylcholine. Phosphatidylcholines 225-244 lipoprotein lipase Bos taurus 78-96 3942762-2 1986 In a monolayer of egg phosphatidylcholine containing 3 mol% [14C]trioleoylglycerol, and in the presence of apolipoprotein C-II, a 79 amino acid activator protein for lipoprotein lipase, enzyme activity was maximal at a surface pressure of 21-22 mN X m-1 (37 mumol oleic acid released/h per mg enzyme); enzyme activity was enhanced 9-fold by apolipoprotein C-II. Phosphatidylcholines 22-41 apolipoprotein C2 Bos taurus 107-126 3948674-0 1986 [The role of cytochrome P-450 in the activation of phosphatidyl choline hydrolysis by phospholipase A2]. Phosphatidylcholines 51-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-29 3009039-1 1986 Ca2+-translocating activities of phosphatidylinositol, diacylglycerol and phosphatidic acid were investigated in phosphatidylcholine liposomes. Phosphatidylcholines 113-132 carbonic anhydrase 2 Homo sapiens 0-3 3009039-2 1986 Using a fluorescent indicator of Ca2+ concentration, quin-2, release of encapsulated Ca2+ from egg yolk phosphatidylcholine liposomes containing 2 mol% of one of these lipids was measured at 37 degrees C. The rate of Ca2+ translocation across the liposomal membrane mediated by phosphatidic acid was about 3-fold larger than those mediated by phosphatidylinositol and diacylglycerol. Phosphatidylcholines 104-123 carbonic anhydrase 2 Homo sapiens 85-88 3009039-2 1986 Using a fluorescent indicator of Ca2+ concentration, quin-2, release of encapsulated Ca2+ from egg yolk phosphatidylcholine liposomes containing 2 mol% of one of these lipids was measured at 37 degrees C. The rate of Ca2+ translocation across the liposomal membrane mediated by phosphatidic acid was about 3-fold larger than those mediated by phosphatidylinositol and diacylglycerol. Phosphatidylcholines 104-123 carbonic anhydrase 2 Homo sapiens 85-88 3700364-1 1986 Selectivity factors (Vm/Km) for human and rat lecithin: cholesterol acyltransferases (LCAT) for the transfer of various acyl groups from the 2-position of phosphatidylcholine were determined. Phosphatidylcholines 155-174 lecithin cholesterol acyltransferase Rattus norvegicus 46-84 3700364-1 1986 Selectivity factors (Vm/Km) for human and rat lecithin: cholesterol acyltransferases (LCAT) for the transfer of various acyl groups from the 2-position of phosphatidylcholine were determined. Phosphatidylcholines 155-174 lecithin cholesterol acyltransferase Rattus norvegicus 86-90 3700364-2 1986 By multiplying these values by the proportions of acyl groups at the 2-position of phosphatidylcholine, one can predict the proportions of molecular species of cholesterol ester which will be synthesized by LCAT. Phosphatidylcholines 83-102 lecithin-cholesterol acyltransferase Homo sapiens 207-211 3080314-1 1986 Lecithin: cholesterol acyltransferase (LCAT, phosphatidylcholine: sterol O-acyltransferase, EC 2.3.1.43) was purified approximately 20 000-fold from pig plasma by ultracentrifugation, phenyl-Sepharose and hydroxyapatite chromatography. Phosphatidylcholines 45-64 lecithin-cholesterol acyltransferase Sus scrofa 0-37 3080314-1 1986 Lecithin: cholesterol acyltransferase (LCAT, phosphatidylcholine: sterol O-acyltransferase, EC 2.3.1.43) was purified approximately 20 000-fold from pig plasma by ultracentrifugation, phenyl-Sepharose and hydroxyapatite chromatography. Phosphatidylcholines 45-64 lecithin-cholesterol acyltransferase Sus scrofa 39-43 3080314-13 1986 In contrast, the LCAT activity was significantly reduced by liposomes with phosphatidylcholine/cholesterol molar ratios below 3:1. Phosphatidylcholines 75-94 lecithin-cholesterol acyltransferase Homo sapiens 17-21 3002470-0 1986 Spin-label studies on phosphatidylcholine-cholesterol membranes: effects of alkyl chain length and unsaturation in the fluid phase. Phosphatidylcholines 22-41 spindlin 1 Homo sapiens 0-4 2870863-1 1986 In isotonic saline-buffered conditions, phospholipase A2 from bee venom cleaves up to 65% of the phosphatidylcholine of the rabbit RBC membrane without causing significant hemolysis; however, the volume and the osmotic fragility of the treated RBC is modified. Phosphatidylcholines 97-116 phospholipase A2 Oryctolagus cuniculus 40-56 3948674-0 1986 [The role of cytochrome P-450 in the activation of phosphatidyl choline hydrolysis by phospholipase A2]. Phosphatidylcholines 51-71 phospholipase A2 group IB Homo sapiens 86-102 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. Phosphatidylcholines 13-32 methionine adenosyltransferase 1A Rattus norvegicus 41-64 3944656-6 1986 Milk phosphatidylcholine and sphingomyelin concentrations remained relatively constant throughout lactation (100-200 nmol/ml). Phosphatidylcholines 5-24 Weaning weight-maternal milk Bos taurus 0-4 3944656-9 1986 Milk contained no phospholipase activity capable of forming free choline from phosphatidylcholine or sphingomyelin. Phosphatidylcholines 78-97 Weaning weight-maternal milk Bos taurus 0-4 4091805-1 1985 The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor, was examined in brain homogenates from rats of various ages. Phosphatidylcholines 119-138 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-60 4091805-1 1985 The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor, was examined in brain homogenates from rats of various ages. Phosphatidylcholines 140-146 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-60 3029548-1 1986 The ability of apocytochrome c and the heme containing respiratory chain component, cytochrome c, to induce fusion of phosphatidylcholine (PC) small unilamellar vesicles containing 0-50 mol % negatively charged lipids was examined. Phosphatidylcholines 118-137 cytochrome c, somatic Homo sapiens 18-30 3775794-0 1986 Hydrolysis of short-chain phosphatidylcholines by bee venom phospholipase A2. Phosphatidylcholines 26-46 phospholipase A2 group IB Homo sapiens 60-76 2865977-0 1985 Role of stearoyl-CoA desaturase and 1-acylglycerophosphorylcholine acyltransferase in the regulation of the acyl composition of phosphatidylcholine in rat liver. Phosphatidylcholines 128-147 stearoyl-CoA desaturase Rattus norvegicus 8-31 2865977-1 1985 The role of stearoyl-CoA desaturase and 1-acylglycerophosphorylcholine (1-acylGPC) acyltransferase in regulating acyl composition of microsomal phosphatidylcholine was investigated in rat liver, using rats in five different kinds of physiological state: clofibric acid-fed rats, diabetic rats, insulin-treated diabetic rats, starved rats and starved-refed rats. Phosphatidylcholines 144-163 stearoyl-CoA desaturase Rattus norvegicus 12-35 2865977-6 1985 The physiological significance of stearoyl-CoA desaturase and 1-acylGPC acyltransferase was discussed in relation to the regulation of the acyl composition of phosphatidylcholine. Phosphatidylcholines 159-178 stearoyl-CoA desaturase Rattus norvegicus 34-57 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. Phosphatidylcholines 13-32 methionine adenosyltransferase 1A Rattus norvegicus 66-72 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. Phosphatidylcholines 34-36 methionine adenosyltransferase 1A Rattus norvegicus 41-64 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. Phosphatidylcholines 34-36 methionine adenosyltransferase 1A Rattus norvegicus 66-72 4044030-2 1985 Subsequently, the methylated phosphatidylcholine was degraded by activated phospholipase A2. Phosphatidylcholines 29-48 phospholipase A2 Oryctolagus cuniculus 75-91 4054131-6 1985 With egg yolk phosphatidylcholine as acyl donor, apo E was 15-19% as efficient as apolipoprotein A-I for activation of the acyltransferase. Phosphatidylcholines 14-33 apolipoprotein E Homo sapiens 49-54 4054131-7 1985 Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control). Phosphatidylcholines 173-192 apolipoprotein E Homo sapiens 0-5 4054131-7 1985 Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control). Phosphatidylcholines 276-295 apolipoprotein E Homo sapiens 0-5 4056060-5 1985 Finally, an increase in cell recognition as determined by monocyte phagocytosis and adherence in vitro, as well as decreased phosphatidylcholine accessibility to bee venom phospholipase A2, was found in H2O2-treated erythrocytes compared with controls. Phosphatidylcholines 125-144 phospholipase A2 group IB Homo sapiens 172-188 2412585-3 1985 In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments. Phosphatidylcholines 45-64 myelin basic protein Homo sapiens 70-90 4041470-1 1985 Apolipoprotein A-IV, apolipoprotein E-2 and apolipoprotein E-3 were individually incorporated into defined phosphatidylcholine/cholesterol liposomes for study of lecithin:cholesterol acyltransferase activation. Phosphatidylcholines 107-126 apolipoprotein A4 Homo sapiens 0-39 4041470-1 1985 Apolipoprotein A-IV, apolipoprotein E-2 and apolipoprotein E-3 were individually incorporated into defined phosphatidylcholine/cholesterol liposomes for study of lecithin:cholesterol acyltransferase activation. Phosphatidylcholines 107-126 apolipoprotein E Homo sapiens 44-62 3931645-7 1985 Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 68-87 angiotensinogen Rattus norvegicus 0-14 3931645-7 1985 Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 89-91 angiotensinogen Rattus norvegicus 0-14 3931645-9 1985 Thus we assume that angiotensin II may induce a shift in phospholipid synthesis from PC and PE to phosphoinositides. Phosphatidylcholines 85-87 angiotensinogen Rattus norvegicus 20-34 2413893-1 1985 Myelin basic protein induces slow and limited fusion of phospholipid vesicles composed of a mixture of phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 103-122 myelin basic protein Homo sapiens 0-20 3932344-7 1985 The formation of complexes between vesicles and apo-A-I followed a two-step process; below or above the lipid phase transition temperature (Tc), apo-A-I bound to phosphatidylcholine vesicles but caused little leakage of contents. Phosphatidylcholines 162-181 apolipoprotein A1 Homo sapiens 48-55 3932344-7 1985 The formation of complexes between vesicles and apo-A-I followed a two-step process; below or above the lipid phase transition temperature (Tc), apo-A-I bound to phosphatidylcholine vesicles but caused little leakage of contents. Phosphatidylcholines 162-181 apolipoprotein A1 Homo sapiens 145-152 3862730-4 1985 Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN). Phosphatidylcholines 104-123 phospholipase A2 group IB Homo sapiens 68-84 3862730-4 1985 Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN). Phosphatidylcholines 125-127 phospholipase A2 group IB Homo sapiens 68-84 3002436-5 1985 With the maltosides, changing the length of the alkyl tail affected the activity of cytochrome c oxidase in a manner quite similar to that reported with synthetic phosphatidylcholines and phosphatidylethanolamines [Vik, S. B., & Capaldi, R. A. Phosphatidylcholines 163-183 zinc finger protein 655 Homo sapiens 215-218 2995357-4 1985 Fusion between the virus envelopes and phosphatidylcholine/cholesterol liposomes was absolutely dependent upon the presence of intact and active hemagglutinin/neuraminidase and fusion viral envelope glycoproteins. Phosphatidylcholines 39-58 neuraminidase 1 Homo sapiens 159-172 4084502-1 1985 Deuterium nuclear magnetic resonance (2H NMR) spectra from aqueous dispersions of phosphatidylcholines in which perdeuterated palmitic acid is esterified at the sn-1 position have several very useful features. Phosphatidylcholines 82-102 solute carrier family 38 member 3 Homo sapiens 161-165 4052568-4 1985 P-31 CP spectra of all the phosphatidylcholines and phosphatidylethanolamine revealed a decrease in intensity in the vicinity of the isotropic chemical shift as long as the lipid was above the gel-to-liquid crystalline phase transition temperature. Phosphatidylcholines 27-47 ATPase H+ transporting V1 subunit E1 Bos taurus 0-4 4041451-3 1985 In cardiolipin liposomes and in cardiolipin-phosphatidylcholine (1:1) liposomes, the drug inhibits the ability of Ca2+ to induce the hexagonal HII phase. Phosphatidylcholines 44-63 carbonic anhydrase 2 Rattus norvegicus 114-117 3930615-6 1985 Therefore, TPA probably is not involved in the turnover of PI in these cells but is involved in the activation of PC hydrolyzing phospholipase A2 and PI hydrolyzing phospholipase C in these keratinocytes releasing arachidonic acid which then undergoes oxygenation reactions to provide biologically active eicosanoids. Phosphatidylcholines 114-116 phospholipase A2, group IB, pancreas Mus musculus 129-145 3841007-1 1985 The effect of the altered polar head group of phosphatidylcholine (PC) on its transbilayer distributions in small unilamellar vesicles containing sphingomyelin (SM) was ascertained with phospholipase A2 as the external membrane probe. Phosphatidylcholines 46-65 phospholipase A2 group IB Homo sapiens 186-202 2413014-2 1985 Purified sodium channels incorporated into phosphatidylcholine (PC) vesicles mediate neurotoxin-activated 22Na+ influx but do not bind the alpha-scorpion toxin from Leiurus quinquestriatus (LqTx) with high affinity. Phosphatidylcholines 43-62 procollagen C-endopeptidase enhancer Rattus norvegicus 64-66 4082107-4 1985 For platelet-derived membranes and for equimolar, charged-lipid/phosphatidylcholine (PC) vesicles, the critical concentrations increased in the following order: platelet-derived membranes approximately equal to phosphatidylserine (PS) approximately equal to phosphatidic acid (PA) less than monomethyl PA and monoethyl PA much less than phosphatidylinositol and phosphatidylglycerol. Phosphatidylcholines 64-83 protocadherin 8 Homo sapiens 85-87 3841007-1 1985 The effect of the altered polar head group of phosphatidylcholine (PC) on its transbilayer distributions in small unilamellar vesicles containing sphingomyelin (SM) was ascertained with phospholipase A2 as the external membrane probe. Phosphatidylcholines 67-69 phospholipase A2 group IB Homo sapiens 186-202 3904950-5 1985 Phosphatidylcholine is made in liver by two alternate pathways, by the CDP-choline pathway and by the methylation of phosphatidylethanolamine. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 71-74 2412224-4 1985 These proteins could be incorporated into phosphatidylcholine liposomes and mediated the specific binding of these liposomes to vitronectin but not to fibronectin. Phosphatidylcholines 42-61 vitronectin Homo sapiens 128-139 4064223-1 1985 The phosphatidylcholine transfer protein (PC-TP) from bovine liver has a binding site for phosphatidylcholine (PC). Phosphatidylcholines 4-23 phosphatidylcholine transfer protein Bos taurus 42-47 4063348-4 1985 For both types of sn-2 acyl chain, assuming a single-exponential correlation time and that the motion is within the rapid regime, the phosphatidylcholine lipid systems are less mobile than their phosphatidylethanolamine analogues. Phosphatidylcholines 134-153 solute carrier family 38 member 5 Homo sapiens 18-22 3931627-4 1985 On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids. Phosphatidylcholines 116-135 transcription factor Maf Cavia porcellus 19-22 3931627-4 1985 On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids. Phosphatidylcholines 137-139 transcription factor Maf Cavia porcellus 19-22 4085087-3 1985 The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity. Phosphatidylcholines 123-142 lecithin-cholesterol acyltransferase Homo sapiens 31-67 4085087-3 1985 The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity. Phosphatidylcholines 123-142 lecithin-cholesterol acyltransferase Homo sapiens 69-73 4085088-2 1985 Removal of the protective group by treatment with HCl in chloroform was followed by subsequent reaction with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form the fluorescent analogue of phosphatidylcholine, 1-oleoyl-2-(NBD)aminocaproyl-sn-glycero-3-phosphocholine, in good yield and with high isomeric purity. Phosphatidylcholines 194-213 OXA1L mitochondrial inner membrane protein Homo sapiens 133-138 4019488-2 1985 The effect of cholesteryl oleate on the lipoprotein lipase-catalyzed hydrolysis of trioleoylglycerol was determined in monolayers of egg phosphatidylcholine at a constant surface pressure of 24 mN m-1. Phosphatidylcholines 137-156 lipoprotein lipase Bos taurus 40-58 3904950-6 1985 Regulation of phosphatidylcholine biosynthesis by the CDP-choline pathway in rat liver is well established. Phosphatidylcholines 14-33 cut-like homeobox 1 Rattus norvegicus 54-57 3904950-7 1985 In most instances, the rate of phosphatidylcholine synthesis is governed by the activity of CTP:phosphocholine cytidylyltransferase, which is present in the cytosol and also associated with microsomes. Phosphatidylcholines 31-50 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 92-131 2990564-1 1985 The Ca2+ dependent incorporation of [14C]ethanolamine, L-[14C]serine and [14C]choline into phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine, respectively, were investigated in membrane preparations from rat heart. Phosphatidylcholines 140-159 carbonic anhydrase 2 Rattus norvegicus 4-7 4038271-0 1985 Degradation of mono-oleoylglycerol, trioleoylglycerol and phosphatidylcholine in emulsions and lipoproteins by rat hepatic acylglycerol lipase. Phosphatidylcholines 58-77 lipase G, endothelial type Rattus norvegicus 136-142 3927906-1 1985 A cell-free human polymorphonuclear leukocyte preparation containing both 15- and 5-lipoxygenase activities was found to oxygenate phosphatidylcholine at carbon-15 of the arachidonic acid moiety. Phosphatidylcholines 131-150 arachidonate 15-lipoxygenase Homo sapiens 74-96 3926761-1 1985 In a continued investigation of lecithin cholesterol acyltransferase reaction with micellar discoidal complexes of phosphatidylcholine, cholesterol, and various water soluble apolipoproteins, we prepared complexes containing human apo-E by the cholate dialysis method. Phosphatidylcholines 115-134 apolipoprotein E Homo sapiens 231-236 4016107-1 1985 Synthetic phosphatidylcholines inhibited thrombin-induced aggregation of rabbit platelets. Phosphatidylcholines 10-30 prothrombin Oryctolagus cuniculus 41-49 4016107-6 1985 The amounts of phosphatidylcholines required for 50% inhibition of platelet aggregation correspond very well to those required for 15% exfoliation of acetylcholinesterase activity, suggesting that there is a close relationship between platelet aggregation and vesiculation of the platelet plasma membrane. Phosphatidylcholines 15-35 ACE-1 Oryctolagus cuniculus 150-170 4052389-1 1985 The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy. Phosphatidylcholines 125-144 lipoprotein lipase Homo sapiens 19-37 4052389-1 1985 The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy. Phosphatidylcholines 125-144 lipoprotein lipase Homo sapiens 39-42 4052389-1 1985 The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy. Phosphatidylcholines 125-144 apolipoprotein C2 Homo sapiens 71-90 4052389-1 1985 The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy. Phosphatidylcholines 125-144 apolipoprotein C2 Homo sapiens 92-99 4016077-1 1985 Cytochrome b5, a protein isolated from the endoplasmic reticulum by detergent extraction, interacts spontaneously with small unilamellar phosphatidylcholine vesicles. Phosphatidylcholines 137-156 cytochrome b5 type A Homo sapiens 0-13 4052389-6 1985 The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces. Phosphatidylcholines 230-249 apolipoprotein C2 Homo sapiens 69-76 4052389-6 1985 The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces. Phosphatidylcholines 230-249 lipoprotein lipase Homo sapiens 190-193 4052389-6 1985 The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces. Phosphatidylcholines 230-249 apolipoprotein C2 Homo sapiens 219-226 4052390-6 1985 Cobra venom phospholipase A2 hydrolyzes monomeric short-chain PE"s at about the same rate as short-chain PC"s but hydrolyzes long-chain PC"s much more rapidly than long-chain PE"s. Phosphatidylcholines 105-107 phospholipase A2 group IB Homo sapiens 12-28 4052390-6 1985 Cobra venom phospholipase A2 hydrolyzes monomeric short-chain PE"s at about the same rate as short-chain PC"s but hydrolyzes long-chain PC"s much more rapidly than long-chain PE"s. Phosphatidylcholines 136-138 phospholipase A2 group IB Homo sapiens 12-28 3929832-0 1985 Effects of amino group modification in discoidal apolipoprotein A-I-egg phosphatidylcholine-cholesterol complexes on their reactions with lecithin:cholesterol acyltransferase. Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 49-67 3929832-0 1985 Effects of amino group modification in discoidal apolipoprotein A-I-egg phosphatidylcholine-cholesterol complexes on their reactions with lecithin:cholesterol acyltransferase. Phosphatidylcholines 72-91 lecithin-cholesterol acyltransferase Homo sapiens 138-174 3929832-1 1985 Discoidal complexes of human apolipoprotein A-I-egg phosphatidylcholine-cholesterol were prepared by the sodium cholate dialysis procedure and were reacted to varying extents with the amino group reagents citraconic anhydride, diketene, and formaldehyde in the presence of sodium borohydride. Phosphatidylcholines 52-71 apolipoprotein A1 Homo sapiens 29-47 3998733-4 1985 The incubation of microsomes with CDP-[14C]choline or [14C]choline showed that most of the newly synthesized phosphatidylcholine molecules were localized in the external leaflet. Phosphatidylcholines 109-128 cut like homeobox 1 Homo sapiens 34-37 2988634-1 1985 Apolipoprotein A-I/phosphatidylcholine/cholesterol complexes formed in a 2-chloroethanol-water mixture. Phosphatidylcholines 19-38 apolipoprotein A1 Homo sapiens 0-18 2988634-2 1985 Apolipoprotein A-I can spontaneously associate with phosphatidylcholine and cholesterol in 2-chloroethanol-water mixture. Phosphatidylcholines 52-71 apolipoprotein A1 Homo sapiens 0-18 2988634-4 1985 The apolipoprotein A-I/phosphatidylcholine/cholesterol complexes were isolated by gel chromatography. Phosphatidylcholines 23-42 apolipoprotein A1 Homo sapiens 4-22 4005286-15 1985 This choline was derived, in part, from the degradation of phosphatidylcholine, and we suggest that phospholipase A activity was the primary initiator of choline release from this phospholipid. Phosphatidylcholines 59-78 phospholipase A and acyltransferase 1 Rattus norvegicus 100-115 2990533-4 1985 Spin-labeling and radiolabeling data show that the incorporation of (4 +/- 1) X 10(6) molecules of exogenous phosphatidylcholine per cell converts discocytes to stage 3 echinocytes with about 35 conical spicules. Phosphatidylcholines 109-128 spindlin 1 Homo sapiens 0-4 3925588-4 1985 For the activation of 0.25 microM prothrombin by factor Xa in the presence of 50 microM phospholipid (phosphatidylserine/phosphatidylcholine, 25/75; mol/mol) and 5 mM CaCl2 50% inhibition was obtained at 0.28 microM fragment 1 or fragment 1.2. Phosphatidylcholines 121-140 coagulation factor II, thrombin Bos taurus 34-45 2859892-2 1985 The pig small intestinal dipeptidyl peptidase IV was asymmetrically integrated into egg phosphatidylcholine and microvillar lipid vesicles prepared by a beta-octylglucoside dialysis method. Phosphatidylcholines 88-107 dipeptidyl peptidase 4 Sus scrofa 25-48 4041563-0 1985 Hydrolysis of phosphatidylcholine liposomes by lysosomal phospholipase A is maximal at the phase transition temperature of the lipid substrate. Phosphatidylcholines 14-33 phospholipase A and acyltransferase 1 Rattus norvegicus 57-72 4027218-4 1985 By incorporation of rhodopsin into a series of phosphatidylcholines of defined composition, we have determined the properties of the lipid environment that are responsible for the altered spectral behavior. Phosphatidylcholines 47-67 rhodopsin Homo sapiens 20-29 4024704-2 1985 Phosphatidylcholine with arachidonoyl at position 2 was cleaved preferentially by an alkaline phospholipase A2 (pH-optimum 9.0) leading to selective liberation of arachidonic acid. Phosphatidylcholines 0-19 phospholipase A2, group IB, pancreas Mus musculus 94-110 3906543-1 1985 Cortisol, in combination with prolactin and/or insulin, increases the rate of lamellar body phosphatidylcholine synthesis and markedly increases the secretion of lamellar bodies into the ductular lumens of human fetal lung explants maintained in serum-free medium. Phosphatidylcholines 92-111 insulin Homo sapiens 47-54 3995060-4 1985 As well, concentrations of plasma membrane phosphatidylcholine and phosphatidylethanolamine in thrombin-stimulated platelets decreased by 20 and 9%, respectively, when compared with their control values. Phosphatidylcholines 43-62 coagulation factor II, thrombin Homo sapiens 95-103 3855929-7 1985 NK effector cells treated with phosphatidylcholine complexed with polyvinylpyrrolidone (PVP) and bovine serum albumin (BSA) showed increased membrane fluidity. Phosphatidylcholines 31-50 albumin Homo sapiens 104-117 3986373-4 1985 It has been shown in model experiments with incorporation into the tumor cell membrane of brain ganglioside GD3 combined with thymic LacCer or with egg phosphatidylcholine that the increase in the sensitivity of the tumor cell membrane to spleen effectors is linked with a change in the properties of the lipid membrane matrix under the effect of unsaturated fatty acids (e.g. in experiments with phosphatidylcholine). Phosphatidylcholines 397-416 GRDX Homo sapiens 108-111 3885949-4 1985 The action of insulin also depends on the phosphatidylcholine: phosphatidic acid molar ratio, and buffer and vesicles concentration. Phosphatidylcholines 42-61 insulin Bos taurus 14-21 4016572-1 1985 Addition of cardiolipin or diacylglycerol to dispersions of phosphatidylcholine greatly increased hydrolysis by snake venom or pancreatic phospholipase A2, as well as by a microbial phospholipase. Phosphatidylcholines 60-79 phospholipase A2 group IB Homo sapiens 138-154 4016574-11 1985 Hydrolysis of phosphatidylcholine by phospholipase A2 leads to an enzymatic stimulation. Phosphatidylcholines 14-33 phospholipase A2 Ovis aries 37-53 3919008-0 1985 Kinetics of lecithin-cholesterol acyltransferase reaction with discoidal complexes of apolipoprotein A-I.phosphatidylcholine.ether phospholipid.cholesterol. Phosphatidylcholines 105-124 lecithin-cholesterol acyltransferase Homo sapiens 12-48 3919022-4 1985 Inhibition of platelet aggregation by CRP is accompanied by an inhibition of arachidonic acid release from both phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 112-131 C-reactive protein Homo sapiens 38-41 3921018-5 1985 Hydrolysis of PC by phospholipase A2 is likely to be the major route of arachidonic acid liberation in either IgE-mediated or non-IgE activation in mast cells. Phosphatidylcholines 14-16 phospholipase A2 group IB Rattus norvegicus 20-36 2982418-4 1985 Addition of phospholipase C resulted in increased synthesis of phosphatidylcholine from both labeled precursors; no significant changes were found in synthesis of most of the other 3H-labeled lipids. Phosphatidylcholines 63-82 LOC100009319 Oryctolagus cuniculus 12-27 3919008-0 1985 Kinetics of lecithin-cholesterol acyltransferase reaction with discoidal complexes of apolipoprotein A-I.phosphatidylcholine.ether phospholipid.cholesterol. Phosphatidylcholines 105-124 apolipoprotein A1 Homo sapiens 86-104 3972013-4 1985 These data suggest that the process of receptor-mediated endocytosis of transferrin can proceed normally in the absence of de novo phosphatidylcholine synthesis. Phosphatidylcholines 131-150 transferrin Homo sapiens 72-83 3838686-7 1985 From these results we propose a long-range attractive interaction between bound Ca2+ and the polar head groups of distant phosphatidylcholine molecules. Phosphatidylcholines 122-141 carbonic anhydrase 2 Homo sapiens 80-83 4096905-1 1985 Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows. Phosphatidylcholines 118-137 cytochrome b5 type A Homo sapiens 0-13 4096905-1 1985 Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows. Phosphatidylcholines 139-141 cytochrome b5 type A Homo sapiens 0-13 3973457-1 1985 In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol. Phosphatidylcholines 19-38 lecithin cholesterol acyltransferase Rattus norvegicus 72-108 2982398-7 1985 Among phospholipids with the same acyl moiety but different head groups, phosphatidylethanolamine was found to be more effective than phosphatidylcholine in protecting cytochrome c oxidase from thermodenaturation. Phosphatidylcholines 134-153 cytochrome c, somatic Homo sapiens 168-180 3155927-9 1985 Mixtures of phosphatidylserine and phosphatidylcholine produced intermediate ATPase activities, with the maximal value dependent on the phosphatidylserine concentration. Phosphatidylcholines 35-54 dynein axonemal heavy chain 8 Homo sapiens 77-83 3918999-7 1985 Complexes of phosphatidylcholines substituted with two saturated fatty acids served as substrate for lecithin:cholesterol acyltransferase even in the absence of any activator protein. Phosphatidylcholines 13-33 lecithin-cholesterol acyltransferase Homo sapiens 101-137 3838249-3 1985 As part of the characterization of this preparation, the surface orientation of the carbohydrates of rhodopsin, assembled from purified bovine rhodopsin and egg phosphatidylcholine was examined, and is the topic of this report. Phosphatidylcholines 161-180 rhodopsin Bos taurus 101-110 3987344-5 1985 The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine. Phosphatidylcholines 283-302 phospholipase A2 group IB Rattus norvegicus 16-32 3987344-5 1985 The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine. Phosphatidylcholines 283-302 phospholipase A2 group IB Rattus norvegicus 34-38 3973457-1 1985 In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol. Phosphatidylcholines 19-38 lecithin cholesterol acyltransferase Rattus norvegicus 110-114 3973457-1 1985 In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol. Phosphatidylcholines 41-43 lecithin cholesterol acyltransferase Rattus norvegicus 72-108 3973457-1 1985 In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol. Phosphatidylcholines 41-43 lecithin cholesterol acyltransferase Rattus norvegicus 110-114 3881128-0 1985 Rhodopsin-egg phosphatidylcholine reconstitution by an octyl glucoside dilution procedure. Phosphatidylcholines 14-33 rhodopsin Bos taurus 0-9 3992006-7 1985 Although LCAT activator (apoprotein A-I) was not markedly altered by dietary ethanol and the concentration of LCAT substrates (HDL free cholesterol and phosphatidyl choline) was significantly elevated in the High Ethanol group, subtle modifications in substrate-product composition may account for the observed reduction in cholesterol esterification. Phosphatidylcholines 152-172 lecithin-cholesterol acyltransferase Homo sapiens 110-114 2981549-2 1985 We have characterized the quenching of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine by Co2+ in egg phosphatidylcholine (PC) lipid bilayer vesicles. Phosphatidylcholines 116-135 complement C2 Homo sapiens 104-107 3881128-1 1985 The transmembrane protein bovine rhodopsin was reconstituted with egg phosphatidylcholine (PC) by using a modified detergent dilution technique employing the nonionic detergent octyl-beta-D-glucoside (octyl glucoside). Phosphatidylcholines 70-89 rhodopsin Bos taurus 33-42 3926598-4 1985 When phosphatidylcholine micelles were incubated with the enzyme in the presence of gabexate mesilate, the mode of inhibition of the enzyme action by the drug appeared to be noncompetitive and Ki of gabexate mesilate for phospholipase A2 was 0.77 mM. Phosphatidylcholines 5-24 phospholipase A2 group IB Homo sapiens 221-237 2578294-1 1985 Two lipid transfer proteins, designated lipid transfer protein-I (Mr 69 000) and lipid transfer protein-II (Mr 55 000), each of which facilitates the transfer of radiolabelled cholesteryl ester, triacylglycerol and phosphatidylcholine between plasma lipoproteins, were purified from human plasma. Phosphatidylcholines 215-234 cholesteryl ester transfer protein Homo sapiens 40-64 2578294-1 1985 Two lipid transfer proteins, designated lipid transfer protein-I (Mr 69 000) and lipid transfer protein-II (Mr 55 000), each of which facilitates the transfer of radiolabelled cholesteryl ester, triacylglycerol and phosphatidylcholine between plasma lipoproteins, were purified from human plasma. Phosphatidylcholines 215-234 phospholipid transfer protein Homo sapiens 66-106 2578294-10 1985 Most plasma phosphatidylcholine transfer activity is mediated by a protein (or proteins) other than lipid transfer protein-I and lipid transfer protein-II. Phosphatidylcholines 12-31 phospholipid transfer protein Homo sapiens 129-154 2578294-11 1985 In lipoprotein-free plasma all cholesteryl ester and triacylglycerol transfer activity, and some phosphatidylcholine transfer activity, is mediated by lipid transfer protein-I (or lipid transfer protein-I and an antigenically similar protein, lipid transfer protein-II. Phosphatidylcholines 97-116 cholesteryl ester transfer protein Homo sapiens 151-175 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. Phosphatidylcholines 55-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. Phosphatidylcholines 134-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 4084264-1 1985 Cleavage of mitochondrial phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL) by phospholipase A2 but not selective degradation of PE and PC by phospholipase C dissociates creatine kinase from rat heart mitochondria. Phosphatidylcholines 57-76 phospholipase A2 group IB Rattus norvegicus 106-122 4084264-1 1985 Cleavage of mitochondrial phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL) by phospholipase A2 but not selective degradation of PE and PC by phospholipase C dissociates creatine kinase from rat heart mitochondria. Phosphatidylcholines 78-80 phospholipase A2 group IB Rattus norvegicus 106-122 3997795-3 1985 At the same time it was metabolically converted into phosphatidylcholine (PC) and free fatty acid (FFA) plus glycerophosphorylcholine by the actions of acyltransferase and lysophospholipase, respectively. Phosphatidylcholines 53-72 phospholipase B1 Homo sapiens 172-189 4092816-1 1985 The hydrolysis of acyl esters in phosphatidylcholine by phospholipase A2 (PLA2) for human placental blood vessel was investigated. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 56-72 4092816-1 1985 The hydrolysis of acyl esters in phosphatidylcholine by phospholipase A2 (PLA2) for human placental blood vessel was investigated. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 74-78 4092816-3 1985 In contrast to rat tissues, the human placental blood vessel PLA2 showed a selective preference for arachidonate over linoleate acyl group at the sn-2 position of phosphatidylcholine. Phosphatidylcholines 163-182 phospholipase A2 group IB Homo sapiens 61-65 3839593-3 1985 Cytidine diphosphocholine (CDP-choline) is an essential intermediary in the biosynthesis of PC. Phosphatidylcholines 92-94 cut like homeobox 1 Homo sapiens 27-30 6517928-4 1984 31P-NMR of phosphatidylcholine indicates that diacylglycerol causes an isotropic component to develop in the spectrum of the bilayers which correlates approximately with the enhancement of phospholipase A2 attack. Phosphatidylcholines 11-30 phospholipase A2 group IB Homo sapiens 189-205 4001746-1 1985 Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2. Phosphatidylcholines 222-241 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-35 4001746-1 1985 Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2. Phosphatidylcholines 222-241 phosphatidylethanolamine N-methyltransferase Homo sapiens 37-41 4001746-1 1985 Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2. Phosphatidylcholines 222-241 phospholipase A2 group IB Homo sapiens 256-272 6594703-5 1984 That the lipase was functioning in the cultured brain cells was indicated by uptake and incorporation of radioactivity from tri[( 1-14C]oleoyl)glycerol into cellular triacylglycerols, and into more polar lipids, such as phosphatidylcholine. Phosphatidylcholines 220-239 lipase G, endothelial type Rattus norvegicus 9-15 6517595-5 1984 Normal-phase HPLC analysis confirmed that both PC and PE in the liver phospholipids were peroxidized after CCl4 treatment. Phosphatidylcholines 47-49 C-C motif chemokine ligand 4 Rattus norvegicus 107-111 6508805-2 1984 When liposomes containing phosphatidylcholine were incubated with prothrombin and INA, the amount of incorporated label was greater in the absence of added calcium. Phosphatidylcholines 26-45 coagulation factor II, thrombin Homo sapiens 66-77 6523448-5 1984 These results show that thrombin-induced liberation of [3H]-arachidonic acid occurs entirely by a TFP-sensitive mechanism, and suggest that the major portion of the arachidonate is liberated from phosphatidylcholine with a possible contribution from phosphatidylinositol. Phosphatidylcholines 196-215 coagulation factor II, thrombin Homo sapiens 24-32 6091780-5 1984 Thrombin caused loss of [14C]arachidonate-labelled phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol. Phosphatidylcholines 51-70 coagulation factor II, thrombin Sus scrofa 0-8 6497946-11 1984 The major phospholipids in plasma are identical in both groups and there is an identical change under the PUFA diet, sphingomyelin is increased and phosphatidylcholine is decreased, which may be related to an increase of the HDL2/HDL3 ratio. Phosphatidylcholines 148-167 junctophilin 3 Homo sapiens 225-229 6436245-3 1984 Separation of platelet phospholipids and subsequent resolution into individual molecular species by high-performance liquid chromatography revealed that the newly formed alkylacyl-GPC was exclusively alkylarachidonoyl-GPC and that the arachidonoyl group for acylation of alkyllyso-GPC was provided by phosphatidylcholine. Phosphatidylcholines 301-320 glycophorin C (Gerbich blood group) Homo sapiens 180-183 6094742-8 1984 The effect of low pH on sodium fluoride-stimulated and D-Ala enk-inhibited adenylate cyclase could be reversed by addition of either cis-vaccenic acid or phosphatidylcholine to treated membranes, but the effect on GTP regulation of binding was not reversed by lipid incorporation. Phosphatidylcholines 154-173 proenkephalin Rattus norvegicus 61-64 6392853-8 1984 In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 235-254 Ino4p Saccharomyces cerevisiae S288C 107-111 6392853-8 1984 In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 235-254 Ino2p Saccharomyces cerevisiae S288C 116-120 6095861-9 1984 Cleavage of phosphatidylcholine to lyso-phosphatidylcholine occurred in the presence of either adrenergic agonists or histamine, indicating an involvement of phospholipase A2. Phosphatidylcholines 12-31 phospholipase A2 group IB Rattus norvegicus 158-174 6085169-0 1984 Substance P: binding to unilamellar and multilamellar liposomes made from mixtures of phosphatidylcholine and phosphatidic acid. Phosphatidylcholines 86-105 tachykinin precursor 1 Homo sapiens 0-11 6441309-7 1984 These results suggest that endogenous phospholipase A2 may break membrane phosphatidyl choline into lysophosphatidyl choline and fatty acid, when the acrosome reaction occurs. Phosphatidylcholines 74-94 phospholipase A2 group IB Homo sapiens 38-54 6510702-11 1984 It has been shown by freeze-fracture electron microscopy that the addition of Ca+2, Mg+2, Mn+2 or Cd+2 to suspensions of egg phosphatidylcholine and cardiolipin (1:1 or 3:1) leads to the formation of numerous intramembrane particles (imp"s) and crater-like (stalk) structures. Phosphatidylcholines 125-144 carbonic anhydrase 2 Homo sapiens 78-82 6391991-5 1984 The phosphatidyl choline and disaturated phosphatidyl choline were also higher in the fetuses injected with insulin+hydrocortisone than in fetuses injected with insulin or hydrocortisone alone. Phosphatidylcholines 4-24 insulin Oryctolagus cuniculus 108-115 6391991-5 1984 The phosphatidyl choline and disaturated phosphatidyl choline were also higher in the fetuses injected with insulin+hydrocortisone than in fetuses injected with insulin or hydrocortisone alone. Phosphatidylcholines 4-24 insulin Oryctolagus cuniculus 161-168 6391991-6 1984 These results suggest that insulin increases the phosphatidyl choline and disaturated phosphatidyl choline content in lung tissue in fetal rabbits in vivo, and that in the presence of hydrocortisone, insulin appears to have an additive effect. Phosphatidylcholines 49-69 insulin Oryctolagus cuniculus 27-34 6391991-6 1984 These results suggest that insulin increases the phosphatidyl choline and disaturated phosphatidyl choline content in lung tissue in fetal rabbits in vivo, and that in the presence of hydrocortisone, insulin appears to have an additive effect. Phosphatidylcholines 86-106 insulin Oryctolagus cuniculus 27-34 6437832-7 1984 Phosphatidylethanolamine and phosphatidylcholine were the most significant donors of AA during thrombin stimulation. Phosphatidylcholines 29-48 coagulation factor II, thrombin Homo sapiens 95-103 6477954-5 1984 Egg phosphatidylcholine complexes of both human apolipoprotein A-I and apolipoprotein C"s competed for the HDL-binding sites, but phosphatidylcholine vesicles alone did not. Phosphatidylcholines 4-23 apolipoprotein A1 Homo sapiens 48-66 6237161-7 1984 The PC-binding proteins possessed a typical phospholipase A2 activity, which was maximal at pH 9.5, depended on Ca++, and was specific for cleavage of fatty acid from the sn-2 position of phosphatidylcholine. Phosphatidylcholines 188-207 phospholipase A2, group IB, pancreas Mus musculus 44-60 6089898-11 1984 Therefore, while in the type II pneumocyte significant amounts of phosphatidylcholine (particularly the disaturated species) and phosphatidylethanolamine may be synthesized de novo, enzymes responsible for remodeling (phospholipase A2 and acyltransferases) may play an important role in establishing the final molecular species composition of both phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 348-367 phospholipase A2 group IB Rattus norvegicus 218-234 6094205-10 1984 After cell prelabelling for 2 h in the presence of TSH, PAF-acether added for 15 min completely counteracted the hormone effects on PI and phosphatidylcholine (PC) but increased the phosphatidic acid (PA) labelling. Phosphatidylcholines 139-158 PCNA clamp associated factor Homo sapiens 56-59 6094205-10 1984 After cell prelabelling for 2 h in the presence of TSH, PAF-acether added for 15 min completely counteracted the hormone effects on PI and phosphatidylcholine (PC) but increased the phosphatidic acid (PA) labelling. Phosphatidylcholines 160-162 PCNA clamp associated factor Homo sapiens 56-59 6548158-3 1984 Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence. Phosphatidylcholines 102-121 LOC104974671 Bos taurus 19-35 6548158-3 1984 Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence. Phosphatidylcholines 102-121 lipoprotein lipase Bos taurus 52-70 6438077-1 1984 Interaction of human apolipoprotein A-II (apoA-II) with egg yolk phosphatidylcholine unilamellar vesicles (diameter, 20-26 nm) was studied. Phosphatidylcholines 65-84 apolipoprotein A2 Homo sapiens 21-40 6438077-1 1984 Interaction of human apolipoprotein A-II (apoA-II) with egg yolk phosphatidylcholine unilamellar vesicles (diameter, 20-26 nm) was studied. Phosphatidylcholines 65-84 apolipoprotein A2 Homo sapiens 42-49 6501257-7 1984 These reactions were absolutely dependent on cytochrome P-450p-2 and NADPH-cytochrome P-450 reductase, and stimulated by addition of phosphatidylcholine and cytochrome b5. Phosphatidylcholines 133-152 cytochrome P450 4A5 Oryctolagus cuniculus 45-64 6438077-10 1984 Thus the parameters represent the equilibrium binding of apoA-II to the surface of phosphatidylcholine unilamellar vesicles. Phosphatidylcholines 83-102 apolipoprotein A2 Homo sapiens 57-64 6501257-7 1984 These reactions were absolutely dependent on cytochrome P-450p-2 and NADPH-cytochrome P-450 reductase, and stimulated by addition of phosphatidylcholine and cytochrome b5. Phosphatidylcholines 133-152 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 69-101 6487589-3 1984 A symmetric and sharp wide-angle reflection at 4.11 A indicates that the hydrocarbon chains in hydrated C(18):C(10)PC bilayers are more tightly packed than in usual gel-state phosphatidylcholine bilayers and that there is no hydrocarbon chain tilt. Phosphatidylcholines 175-194 Bardet-Biedl syndrome 9 Homo sapiens 104-109 6491538-2 1984 The microbial enzyme (GCAT) catalyzed acyl transfer using phosphatidylcholine and cholesterol in all of the lipoprotein fractions, presumably because it has no apolipoprotein cofactor. Phosphatidylcholines 58-77 glycine C-acetyltransferase Homo sapiens 22-26 6468604-2 1984 Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine. Phosphatidylcholines 96-115 phospholipase A2 group IB Homo sapiens 48-64 6466698-0 1984 Lipoprotein lipase mediated uptake of non-degradable ether analogues of phosphatidylcholine and cholesteryl ester by cultured cells. Phosphatidylcholines 72-91 lipoprotein lipase Homo sapiens 0-18 6743672-4 1984 Saturated phosphatidic acid, diacylglycerol and phosphatidylglycerol were nearly equally labeled in the sn-1 and sn-2 positions, whereas saturated phosphatidylcholine was preferentially labeled in the sn-2 position. Phosphatidylcholines 147-166 solute carrier family 38, member 5 Rattus norvegicus 201-205 6746652-0 1984 Relative degradation of different molecular species of phosphatidylcholine in thrombin-stimulated human platelets. Phosphatidylcholines 55-74 coagulation factor II, thrombin Homo sapiens 78-86 6746652-2 1984 This was of interest since previous work using radioactive fatty acids had led to the conclusion that the 1-acyl-2-arachidonoyl species of phosphatidylcholine is exclusively hydrolyzed in thrombin-stimulated platelets. Phosphatidylcholines 139-158 coagulation factor II, thrombin Homo sapiens 188-196 6746652-3 1984 Within 90 s, the thrombin-dependent release of [14C]arachidonic acid from phosphatidylcholine amounted to 25% but only 3 and 6% for oleic and linoleic acids, respectively, in general agreement with previous work. Phosphatidylcholines 74-93 coagulation factor II, thrombin Homo sapiens 17-25 6746652-4 1984 However, for [3H]glycerol-labeled phosphatidylcholine, all molecular species (saturates, monoenes, dienes, trienes, tetraenes, and greater than tetraenes) were subject to significant hydrolysis in the presence of thrombin within 90 s, ranging from 12-24% across the various classes. Phosphatidylcholines 34-53 coagulation factor II, thrombin Homo sapiens 213-221 6746652-7 1984 These results indicate that the 1-acyl-2-arachidonoyl species of phosphatidylcholine are not exclusively degraded by phospholipase A2 activity in thrombin-stimulated platelets and suggest that the differential compartmentation of molecular species of phosphatidylcholine according to their metabolic origins can influence their apparent susceptibility to hydrolysis. Phosphatidylcholines 65-84 phospholipase A2 group IB Homo sapiens 117-133 6746652-7 1984 These results indicate that the 1-acyl-2-arachidonoyl species of phosphatidylcholine are not exclusively degraded by phospholipase A2 activity in thrombin-stimulated platelets and suggest that the differential compartmentation of molecular species of phosphatidylcholine according to their metabolic origins can influence their apparent susceptibility to hydrolysis. Phosphatidylcholines 65-84 coagulation factor II, thrombin Homo sapiens 146-154 6549154-0 1984 Enhanced lipid peroxidation of erythrocyte membranes and phosphatidylcholine liposomes induced by a xanthine oxidase system in the presence of catalase. Phosphatidylcholines 57-76 catalase Homo sapiens 143-151 6430345-10 1984 These reaction rates correlate well with the apolipoprotein A-I fluorescence properties and indicate that the apolipoprotein structure, reflected at the interface with phosphatidylcholine, may be the most important factor in determining complex reactivity with lecithin:cholesterol acyltransferase. Phosphatidylcholines 168-187 apolipoprotein A1 Homo sapiens 45-63 6430345-10 1984 These reaction rates correlate well with the apolipoprotein A-I fluorescence properties and indicate that the apolipoprotein structure, reflected at the interface with phosphatidylcholine, may be the most important factor in determining complex reactivity with lecithin:cholesterol acyltransferase. Phosphatidylcholines 168-187 lecithin-cholesterol acyltransferase Homo sapiens 261-297 6746620-0 1984 Effect of apolipoprotein C-II on the temperature dependence of lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholines. Phosphatidylcholines 106-126 apolipoprotein C2 Homo sapiens 10-29 6464031-2 1984 T-2 toxin significantly elevated total liver lipids, triglycerides, free cholesterol, total phospholipids and phosphatidyl choline, whereas the level of sphingomyelin + lysophosphatidyl ethanolamine was reduced. Phosphatidylcholines 110-130 brachyury 2 Rattus norvegicus 0-3 6746620-0 1984 Effect of apolipoprotein C-II on the temperature dependence of lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholines. Phosphatidylcholines 106-126 lipoprotein lipase Homo sapiens 63-81 6746620-9 1984 We propose that the apo-C-II-mediated increase in the rate of the lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine is associated with transfer of a fatty acyl chain of the substrate or product to a more hydrophobic environment within the transition state complex. Phosphatidylcholines 109-128 apolipoprotein C2 Homo sapiens 20-28 6746620-9 1984 We propose that the apo-C-II-mediated increase in the rate of the lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine is associated with transfer of a fatty acyl chain of the substrate or product to a more hydrophobic environment within the transition state complex. Phosphatidylcholines 109-128 lipoprotein lipase Homo sapiens 66-84 6428457-10 1984 Angiotensin II increased turnover of phosphatidylinositol and also phosphatidylcholine, as determined by incorporation of [14C]arachidonic acid. Phosphatidylcholines 67-86 angiotensinogen Rattus norvegicus 0-14 6373768-2 1984 Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine. Phosphatidylcholines 341-360 insulin Homo sapiens 58-65 6746804-0 1984 High-performance liquid chromatography in the analysis of the products of phospholipase A hydrolysis of phosphatidylcholine. Phosphatidylcholines 104-123 phospholipase A and acyltransferase 1 Homo sapiens 74-89 6373768-2 1984 Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine. Phosphatidylcholines 366-385 insulin Homo sapiens 58-65 6743291-0 1984 Serum albumin enhances the uptake of [3H]cholesterol from phosphatidylcholine vesicles by cultured human fibroblasts. Phosphatidylcholines 58-77 albumin Homo sapiens 0-13 6426514-1 1984 A peptide (P-9) comprising amino acids 307 to 385 of bovine serum albumin induced the fusion of small unilamellar vesicles of phosphatidylcholine at low pH. Phosphatidylcholines 126-145 exosome component 8 Homo sapiens 11-14 6723880-6 1984 Slight, but significant, differences were found between the B6 and D2 strains for the concentrations (microgram/100 mg wet weight) of sphingomyelin, phosphatidylcholine, and cerebrosides. Phosphatidylcholines 149-168 defensin beta 2 Mus musculus 60-69 6587389-1 1984 Spin-labeled analogs of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been used to study phospholipid transverse diffusion and asymmetry in the human erythrocyte membrane. Phosphatidylcholines 24-43 spindlin 1 Homo sapiens 0-4 6326825-2 1984 Microsomal glucose-6-phosphatase from rat liver is activated by phosphatidylcholine but inhibited by lysophosphatidylcholine. Phosphatidylcholines 64-83 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 11-32 24458605-5 1984 It is concluded that galactolipids and phosphatidylcholine are responsible for the stability of CP1a, CP1 and CPa, respectively. Phosphatidylcholines 39-58 carboxypeptidase A1 Homo sapiens 110-113 6427214-1 1984 Micellar, discoidal complexes of human apolipoproteins A-I, A-II, C-I, C-II, C-III-1, and C-III-2 with egg phosphatidylcholine (egg-PC) and cholesterol were prepared by the cholate dialysis method. Phosphatidylcholines 107-126 NLR family pyrin domain containing 3 Homo sapiens 39-69 6723644-2 1984 The phosphate transport protein (PTP) has been isolated from beef heart mitochondria in the presence of cardiolipin and reconstituted in asolectin and phosphatidylcholine vesicles. Phosphatidylcholines 151-170 solute carrier family 25 member 3 Homo sapiens 4-31 6723644-2 1984 The phosphate transport protein (PTP) has been isolated from beef heart mitochondria in the presence of cardiolipin and reconstituted in asolectin and phosphatidylcholine vesicles. Phosphatidylcholines 151-170 solute carrier family 25 member 3 Homo sapiens 33-36 6715338-2 1984 This phospholipase A1 activity was relatively specific for phosphatidic acid; the addition of several other phospholipids in equimolar amounts did not have a significant effect on the hydrolysis of radiolabeled phosphatidic acid, and the specific activity for phosphatidic acid hydrolysis was 20-fold higher than that of the hydrolysis of phosphatidylcholine, phosphatidylethanolamine, or phosphatidylinositol under the conditions used. Phosphatidylcholines 339-358 lipase H Homo sapiens 5-21 6722104-1 1984 Phosphatidylcholine analogues containing a cis- parinaroyl chain at the sn-1, sn-2, or both sn-1 and sn-2 positions (1-PnA-PC, 2-PnA-PC, and diPnA -PC, respectively) have been used to investigate the lipid binding site of the phosphatidylcholine transfer protein (PC-TP) from bovine liver by fluorometric techniques. Phosphatidylcholines 0-19 phosphatidylcholine transfer protein Bos taurus 264-269 6374960-0 1984 Phosphatidylcholine is the major phospholipid providing arachidonic acid for prostacyclin synthesis in thrombin-stimulated human endothelial cells. Phosphatidylcholines 0-19 coagulation factor II, thrombin Homo sapiens 103-111 6372966-0 1984 Glucagon inhibits phosphatidylcholine biosynthesis via the CDP-choline and transmethylation pathways in cultured rat hepatocytes. Phosphatidylcholines 18-37 cut-like homeobox 1 Rattus norvegicus 59-62 6372966-2 1984 Under conditions in which insulin (100 nM) stimulated [3H]acetate incorporation into fatty acid almost twofold, synthesis of phosphatidylcholine via CDP-choline and from phosphatidylethanolamine were unaffected. Phosphatidylcholines 125-144 cut-like homeobox 1 Rattus norvegicus 149-152 6367486-6 1984 Phospholipase A also plays a regulatory role in phosphatidylcholine metabolism because inhibition of this catabolic enzyme favors phospholipid accretion and kidney growth during potassium depletion, whereas stimulation of the enzyme leads to brisk phospholipid breakdown and a decrease in tissue mass during potassium repletion. Phosphatidylcholines 48-67 phospholipase A and acyltransferase 1 Rattus norvegicus 0-15 6365172-1 1984 Phosphatidylcholine (PC) biosynthesis in cultured 3T3 fibroblasts was increased in varying degrees by these mitogenic growth factors: fetal bovine serum, insulin, 12-O-tetradecanoylphorbol-13-acetate, epidermal growth factor, vasopressin, fibroblast growth factor and insulin-like growth factors I and II. Phosphatidylcholines 0-19 arginine vasopressin Homo sapiens 226-237 6365172-1 1984 Phosphatidylcholine (PC) biosynthesis in cultured 3T3 fibroblasts was increased in varying degrees by these mitogenic growth factors: fetal bovine serum, insulin, 12-O-tetradecanoylphorbol-13-acetate, epidermal growth factor, vasopressin, fibroblast growth factor and insulin-like growth factors I and II. Phosphatidylcholines 21-23 arginine vasopressin Homo sapiens 226-237 6204218-1 1984 Human myelin basic protein isolated from the brains of individuals who died with multiple sclerosis was more potent in inducing the aggregation of egg phosphatidylcholine vesicles than was the basic protein isolated from the brains of normal individuals. Phosphatidylcholines 151-170 myelin basic protein Homo sapiens 6-26 6145194-11 1984 While in adipose tissue the somatostatin only caused a strong increase in the specific activity of phosphatidylcholine. Phosphatidylcholines 99-118 somatostatin Mus musculus 28-40 6694756-3 1984 Here we show that the cytoskeletal protein known as band 4.1 specifically associates with the cytoplasmic domain of glycophorin on inside-out erythrocyte membrane vesicles and also with glycophorin reconstituted into phosphatidylcholine vesicles. Phosphatidylcholines 217-236 erythrocyte membrane protein band 4.1 Homo sapiens 52-60 6321243-3 1984 After solubilization by Nonidet-P40 and purification by affinity chromatography and HPLC the isolated receptor was reconstituted into egg phosphatidylcholine vesicles by SM-2 Bio-Bead removal of the Nonidet-P40. Phosphatidylcholines 138-157 SM2 Homo sapiens 170-174 6696448-1 1984 Complex formation between the phenobarbital-inducible form of rabbit liver microsomal cytochrome P-450 incorporated into phosphatidylcholine and detergent-solubilized cytochrome b5 is associated with a low-to-high spin transition of the former pigment. Phosphatidylcholines 121-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-102 6321096-4 1984 Incubation of rabbit young erythrocytes with phosphatidylcholine vesicles (liposomes) to obtain partial depletion of their membrane cholesterol, indicated that cholesterol depletion causes a statistically significant decrease of the (Na+,K+)-stimulated ATPase and acetylcholinesterase activities, but the NAD+ase activity remained almost unchanged. Phosphatidylcholines 45-64 ACE-1 Oryctolagus cuniculus 264-284 6421314-1 1984 Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography. Phosphatidylcholines 69-88 apolipoprotein A1 Homo sapiens 25-43 6421314-1 1984 Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography. Phosphatidylcholines 69-88 apolipoprotein A1 Homo sapiens 45-52 6206229-5 1984 Thus, the stimulated labeling in A23187-treated cells may occur secondary to the action of a phospholipase A2 that favors PC as a substrate. Phosphatidylcholines 122-124 phospholipase A2 group IB Rattus norvegicus 93-109 6724104-1 1984 Bovine luteal cytochrome P-450scc was purified and incorporated into artificial phosphatidylcholine vesicles. Phosphatidylcholines 80-99 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 14-33 6436014-0 1984 A review of plasma apolipoprotein A-I interactions with phosphatidylcholines. Phosphatidylcholines 56-76 apolipoprotein A1 Homo sapiens 19-37 6436014-1 1984 This review starts with a brief introduction to the properties of plasma high-density lipoproteins and their major protein component, apolipoprotein A-I, followed, in the following sections, by an account of experimental work from our laboratory on the interactions of apolipoprotein A-I with synthetic and natural phosphatidylcholines. Phosphatidylcholines 315-335 apolipoprotein A1 Homo sapiens 269-287 6436014-2 1984 The spontaneous reactions of phosphatidylcholine vesicles with apolipoprotein A-I are described in terms of the methods of observation, the properties of the reaction products (vesicular or micellar complexes of protein and lipid), and the kinetic controlling factors in the formation of the micellar products. Phosphatidylcholines 29-48 apolipoprotein A1 Homo sapiens 63-81 6316941-5 1983 Digestion of control liver membranes with exogenous phospholipase A2 decreased phosphatidylcholine and phosphatidylethanolamine levels by 50.6 and 51.2%, respectively, but increased lysophosphatidylcholine and lysophosphatidylethanolamine levels by 12- and 8.4-fold, respectively. Phosphatidylcholines 79-98 phospholipase A2 group IB Canis lupus familiaris 52-68 6708133-9 1984 As a consequence, the (3H)/(14C) ratio in total lipid and in isolated phosphatidylcholine and choline plasmalogen increased after CDP-choline treatment. Phosphatidylcholines 70-89 cut-like homeobox 1 Rattus norvegicus 130-133 6441310-9 1984 Phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol inhibited the phospholipase A2-induced platelet aggregation. Phosphatidylcholines 0-19 phospholipase A2 Apis mellifera 85-101 6660509-1 1983 An alkyl ether analog of phosphatidylcholine was synthesized and used as a ligand to purify acid-extracted phospholipase A2 from bovine ileum smooth muscle by affinity chromatography in the presence of cholate. Phosphatidylcholines 25-44 LOC104974671 Bos taurus 107-123 6643474-0 1983 Chain length dependence of phosphatidylcholine hydrolysis catalyzed by lipoprotein lipase. Phosphatidylcholines 27-46 lipoprotein lipase Bos taurus 71-89 6643474-2 1983 The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates. Phosphatidylcholines 145-165 apolipoprotein C2 Bos taurus 14-33 6643474-2 1983 The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates. Phosphatidylcholines 145-165 apolipoprotein C2 Bos taurus 35-42 6643474-2 1983 The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates. Phosphatidylcholines 145-165 lipoprotein lipase Bos taurus 63-81 6643474-2 1983 The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates. Phosphatidylcholines 145-165 lipoprotein lipase Bos taurus 83-86 6686250-3 1983 The simultaneous addition of PC and ethanolamine also decreased serum apoA-I and cholesterol. Phosphatidylcholines 29-31 apolipoprotein A1 Rattus norvegicus 70-76 6639953-1 1983 D-beta-Hydroxybutyrate dehydrogenase (D-3-hydroxybutyrate: NAD+ oxidoreductase, EC 1.1.1.30) is a lipid-dependent enzyme which has an absolute and specific requirement for phosphatidylcholine for function. Phosphatidylcholines 172-191 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 64-78 6229251-1 1983 Transport of Pr3+ across phosphatidyl choline vesicles, as monitored by 31P nmr, is second-order in the crown ether carboxylic acid 2, as it is with respect to lasalocid (X-537 A). Phosphatidylcholines 25-45 proteinase 3 Homo sapiens 13-16 6680524-1 1983 The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains. Phosphatidylcholines 70-89 phosphatidylethanolamine N-methyltransferase Homo sapiens 17-59 6680524-1 1983 The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains. Phosphatidylcholines 70-89 phosphatidylethanolamine N-methyltransferase Homo sapiens 61-65 6680524-1 1983 The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains. Phosphatidylcholines 91-93 phosphatidylethanolamine N-methyltransferase Homo sapiens 17-59 6680524-1 1983 The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains. Phosphatidylcholines 91-93 phosphatidylethanolamine N-methyltransferase Homo sapiens 61-65 6229251-1 1983 Transport of Pr3+ across phosphatidyl choline vesicles, as monitored by 31P nmr, is second-order in the crown ether carboxylic acid 2, as it is with respect to lasalocid (X-537 A). Phosphatidylcholines 25-45 PTOV1 extended AT-hook containing adaptor protein Homo sapiens 127-133 6680049-4 1983 Membranes prepared from phosphatidylcholines having a single cis double bond at different positions along the sn-2 acyl chain showed roughly the same changes of microviscosity or chain order upon incorporation of cholesterol. Phosphatidylcholines 24-44 solute carrier family 38 member 5 Homo sapiens 110-114 6643460-7 1983 The incubation of Factor V with Factor Xa in the presence of phosphatidylcholine/phosphatidylserine vesicles, CaCl2, and DAPA resulted in a time-dependent increase in cofactor activity. Phosphatidylcholines 61-80 coagulation factor X Homo sapiens 32-41 6644446-5 1983 Phosphatidylcholine and phosphatidylethanolamine were digested by phospholipase A2. Phosphatidylcholines 0-19 phospholipase A2 group IB Homo sapiens 66-82 6885797-10 1983 The apparent Km for AdoMet at pH 10.25 for the conversion of PE to PME was 58 microM, PME to PDE was 65 microM, and PDE to PC was 96 microM. Phosphatidylcholines 123-125 methionine adenosyltransferase 1A Rattus norvegicus 20-26 6352808-1 1983 The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min. Phosphatidylcholines 108-127 interleukin 6 Homo sapiens 34-38 6626154-2 1983 absorption spectrum of retinyl phosphate (Ret-P) solubilized in Triton X-100 micelles, phosphatidylcholine liposomes or rat liver microsomes exhibited a shift from the maximum of 330 nm to 287 nm. Phosphatidylcholines 87-106 ret proto-oncogene Rattus norvegicus 42-45 6316933-5 1983 Reactivation of phosphatidylcholine synthesis in chlorophenylthio-cyclic AMP-supplemented cells with oleate was accompanied by conversion of CTP: phosphocholine cytidylyltransferase into the membrane-bound form, since these cells released the enzyme more slowly after treatment with digitonin. Phosphatidylcholines 16-35 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 141-181 6885797-13 1983 The apparent Km for AdoMet was also estimated for the conversion of exogenous PME to PDE (50 microM) and exogenous PDE to PC (45 microM). Phosphatidylcholines 122-124 methionine adenosyltransferase 1A Rattus norvegicus 20-26 6349697-5 1983 The presence of low doses of insulin (10-25 microunits/ml) caused a significant increase in the incorporation of glucose into both surfactant and residual phosphatidylcholine. Phosphatidylcholines 155-174 insulin Homo sapiens 29-36 6309244-0 1983 Stimulation of hepatic phosphatidylcholine biosynthesis in rats fed a high cholesterol and cholate diet correlates with translocation of CTP: phosphocholine cytidylyltransferase from cytosol to microsomes. Phosphatidylcholines 23-42 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 137-177 6349697-6 1983 Insulin at levels of 100 microunits/ml or higher resulted in a significant decrease in glucose incorporation into both phosphatidylcholine fractions. Phosphatidylcholines 119-138 insulin Homo sapiens 0-7 6349697-8 1983 The addition of 400 microunits/ml of insulin to media containing 20 mM glucose, however, resulted in a 20% decrease in choline incorporation into surfactant phosphatidylcholine but had no effect on choline incorporation into residual phosphatidylcholine. Phosphatidylcholines 157-176 insulin Homo sapiens 37-44 6349697-8 1983 The addition of 400 microunits/ml of insulin to media containing 20 mM glucose, however, resulted in a 20% decrease in choline incorporation into surfactant phosphatidylcholine but had no effect on choline incorporation into residual phosphatidylcholine. Phosphatidylcholines 234-253 insulin Homo sapiens 37-44 6411128-2 1983 Each purified apolipoprotein A-I species was individually incorporated into phosphatidylcholine/cholesterol vesicles by the cholate dialysis method to form proteoliposome common substrates (apolipoprotein A-I/phosphatidylcholine/cholesterol molar ratio of 1:250:12.5) for the enzyme activity assay. Phosphatidylcholines 76-95 apolipoprotein A1 Homo sapiens 14-32 6882789-11 1983 Palmitate was cleaved from both C-1 and C-2 positions of phosphatidylcholine. Phosphatidylcholines 57-76 complement C2 Cavia porcellus 40-43 6411702-2 1983 All the phosphatidylcholine molecules in those particles were readily digested by phospholipase A2 while only the molecules in the outer leaflet of phosphatidylcholine unilamellar vesicles were hydrolyzed under the same conditions. Phosphatidylcholines 8-27 phospholipase A2 group IB Homo sapiens 82-98 6411128-2 1983 Each purified apolipoprotein A-I species was individually incorporated into phosphatidylcholine/cholesterol vesicles by the cholate dialysis method to form proteoliposome common substrates (apolipoprotein A-I/phosphatidylcholine/cholesterol molar ratio of 1:250:12.5) for the enzyme activity assay. Phosphatidylcholines 209-228 apolipoprotein A1 Homo sapiens 14-32 6863295-7 1983 At various time intervals, samples were taken and treated with phospholipase A2, which selectively degrades the PC in the outer monolayer. Phosphatidylcholines 112-114 phospholipase A2 group IB Homo sapiens 63-79 6871217-1 1983 By making use of the capacity of phospholipase A2 to degrade selectively the phospholipid in the outer half of the lipid bilayer of small unilamellar phospholipid/cholesterol vesicles without affecting the retention of a vesicle-encapsulated solute, we demonstrated that the exchange of phosphatidylcholine between such vesicles and human high density lipoprotein involves exclusively the phosphatidylcholine present in the outer monolayer of the vesicle membrane. Phosphatidylcholines 287-306 phospholipase A2 group IB Homo sapiens 33-49 6871217-1 1983 By making use of the capacity of phospholipase A2 to degrade selectively the phospholipid in the outer half of the lipid bilayer of small unilamellar phospholipid/cholesterol vesicles without affecting the retention of a vesicle-encapsulated solute, we demonstrated that the exchange of phosphatidylcholine between such vesicles and human high density lipoprotein involves exclusively the phosphatidylcholine present in the outer monolayer of the vesicle membrane. Phosphatidylcholines 389-408 phospholipase A2 group IB Homo sapiens 33-49 6863928-6 1983 Analysis of specific CsA uptake by cultured human kidney cells and phospholipid vesicles (1:1 molar ratio of phosphatidylcholine:cholesterol) showed both these targets to display a single, low affinity binding site (KD = 1 X 10(-7) M and 2 X 10(-8) M, respectively). Phosphatidylcholines 109-128 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 21-24 6860707-1 1983 Lipid peroxidation induced through cytochrome P-450 activation of cumene hydroperoxide, linolenic acid hydroperoxide and peroxidized phosphatidylcholine in rat liver microsomes is markedly inhibited by either NADH or NADPH. Phosphatidylcholines 133-152 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 35-51 6882441-1 1983 Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly. Phosphatidylcholines 101-120 coagulation factor X Homo sapiens 31-45 6882441-1 1983 Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly. Phosphatidylcholines 122-124 coagulation factor X Homo sapiens 31-45 6134645-1 1983 Chlorpromazine (25 microM) and trifluoperazine (25 microM) inhibited by 5-fold the activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme for phosphatidylcholine biosynthesis, in rat liver cytosol. Phosphatidylcholines 165-184 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 95-134 6873198-2 1983 Liposomes were prepared from various conventional lipids and from a novel photopolymerizable phosphatidylcholine derivative (DPL, bis[1,2-(methacryloyloxy)dodecanoyl]-L-alpha-phosphatidylcholine). Phosphatidylcholines 93-112 prion like protein doppel Homo sapiens 125-128 6615923-1 1983 Superoxide dismutase from erythrocytes and ceruloplasmin of serum inhibit the oxidation of phosphatidylcholine and phosphatidylethanolamine solubilized by cholate. Phosphatidylcholines 91-110 ceruloplasmin Homo sapiens 43-56 6849950-3 1983 In the presence of liver lipase serum triacylglycerol and phosphatidylcholine were hydrolyzed. Phosphatidylcholines 58-77 lipase G, endothelial type Rattus norvegicus 25-31 6863389-4 1983 Since this was observed with glycerol, choline, and orthophosphate labelings, and not with methyl labeling, it appears that the CDP-choline plus diacylglycerol pathway rather than the phosphatidylethanolamine to PC pathway was augmented. Phosphatidylcholines 212-214 cut like homeobox 1 Homo sapiens 128-131 6304057-0 1983 Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis. Phosphatidylcholines 132-151 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 37-76 6688442-14 1983 Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism. Phosphatidylcholines 43-62 lipoprotein lipase Cavia porcellus 0-18 6303434-8 1983 Certain of the phosphatidylcholine replacements produced changes in palmitoyl-CoA hydrolase, NADPH-dependent lipid peroxidase, glucose-6-phosphatase and UDPglucuronyl transferase activities, but they did not closely correlate with the alterations in acyl-CoA:cholesterol acyltransferase activity. Phosphatidylcholines 15-34 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 127-148 6853529-0 1983 Action of lipoprotein lipase on mixed triacylglycerol/phosphatidylcholine monolayers. Phosphatidylcholines 54-73 lipoprotein lipase Homo sapiens 10-28 6631221-3 1983 Approximately 28% of the HDL phosphatidylcholine was hydrolyzed by the hepatic lipase but no change was detected in the cholesterol or apoprotein content of the HDL compared to HDL incubated with heat-inactivated hepatic lipase. Phosphatidylcholines 29-48 lipase C, hepatic type Rattus norvegicus 71-85 6859870-7 1983 Furthermore, lipid hydroperoxides formed by subjecting phosphatidylcholine liposomes to iron ascorbate-induced peroxidation, or those present in aged liposomes, were effectively reduced by glutathione peroxidase when phospholipase A2 was present in the assay. Phosphatidylcholines 55-74 phospholipase A2 group IB Rattus norvegicus 217-233 6688442-0 1983 Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism. Phosphatidylcholines 43-62 lipoprotein lipase Cavia porcellus 0-18 6303406-6 1983 Order parameter values of spin labels in liposomes containing brain phosphatidylcholine and phosphatidylethanolamine increased in parallel with increases in plasmenylethanolamine concentrations, indicating that fluidity was decreasing. Phosphatidylcholines 68-87 spindlin 1 Rattus norvegicus 26-30 6852018-0 1983 Hydrolysis of mixed monomolecular films of phosphatidylcholine/triacylglycerol by pancreatic phospholipase A2. Phosphatidylcholines 43-62 phospholipase A2 group IB Homo sapiens 93-109 6298234-2 1983 Elution of purified receptor (NGF receptor) was accomplished with 0.15 M NaCl, pH 11.0, containing phosphatidylcholine and octylglucoside. Phosphatidylcholines 99-118 nerve growth factor receptor Homo sapiens 30-42 6849876-0 1983 Calorimetric and fluorescence characterization of interactions between cytochrome b5 and phosphatidylcholine bilayers. Phosphatidylcholines 89-108 cytochrome b5 type A Homo sapiens 71-84 6840096-1 1983 The lipid binding site of the phosphatidylcholine transfer protein from bovine liver has been investigated by use of phosphatidylcholine analogs which carry a diazirinophenoxy group linked to the omega-carbon of either the sn-2-[1-14C]hexanoyl (PC I) or sn-2-[1-14C]undecanoyl chain (PC II). Phosphatidylcholines 30-49 serpin family A member 5 Bos taurus 245-249 6302691-5 1983 Bradykinin caused a release of arachidonic acid from methylated phospholipids (phosphatidylcholine) and phosphatidylinositol. Phosphatidylcholines 79-98 kininogen 1 Homo sapiens 0-10 6572961-1 1983 Rat brain synaptosomes contain enzymes, phosphatidylethanolamine N-methyltransferase(s) (EC 2.1.1.17), that catalyze the methylation of endogenous phosphatidylethanolamine to form its mono-, di-, and trimethyl (i.e., phosphatidylcholine) derivatives. Phosphatidylcholines 217-236 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 40-84 6311617-5 1983 Hemoglobin encapsulated in egg phosphatidylcholine vesicles converts to methemoglobin within 2 days at 4 degrees C. By contrast, when a mixture of dimyristoyl phosphatidylcholine, cholesterol and dicetyl phosphate is used there is no acceleration in methemoglobin formation, and the preparation is stable for at least 14 days at 4 degrees C. Phosphatidylcholines 31-50 hemoglobin subunit gamma 2 Homo sapiens 72-85 6833402-1 1983 Liposomes made by sonication of egg yolk phosphatidyl choline support the proliferation of low-density bovine vascular and corneal endothelial cells, and vascular smooth muscle cells maintained on basement laminacoated dishes and exposed to a defined medium supplemented with transferrin. Phosphatidylcholines 41-61 serotransferrin Bos taurus 276-287 6838196-0 1983 Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile salt mixed micelles: kinetic studies in a lecithin-sodium cholate system. Phosphatidylcholines 60-79 phospholipase A2 group IB Homo sapiens 19-35 6838196-1 1983 Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in bile salt lecithin mixed micelles has been studied, utilizing a series of assay mixtures for which the micellar size, weight, and composition had been experimentally determined. Phosphatidylcholines 60-79 phospholipase A2 group IB Homo sapiens 19-35 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 84-103 unk zinc finger Homo sapiens 193-196 6304446-2 1983 The labeling of choline glycerophospholipid (CGP) from radioactive cytidine-5"-diphosphate choline (CDP-choline) in vitro shows a maximum at pH 8.0 (using Hepes [4-(2-hydroxyethyl)-piperazine-1-ethane-2-sulfonic acid] as a buffer) and is stimulated by Mn2+, Mg2+ and diacylglycerol. Phosphatidylcholines 45-48 cut like homeobox 1 Homo sapiens 100-103 6856033-4 1983 At short times after the isotope administration a rapid labeling of phosphatidylcholine was detected, when cells were incubated with CDP-choline. Phosphatidylcholines 68-87 cut like homeobox 1 Homo sapiens 133-136 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 84-103 membrane metalloendopeptidase Homo sapiens 198-201 16662890-6 1983 When [(14)C][unk] MME was supplied, a small amount was hydrolyzed to the free base but the major fate was conversion to [unk] DME, [unk] choline, free choline, and betaine; label also accumulated slowly in phosphatidylcholine. Phosphatidylcholines 206-225 unk zinc finger Homo sapiens 13-16 16662890-6 1983 When [(14)C][unk] MME was supplied, a small amount was hydrolyzed to the free base but the major fate was conversion to [unk] DME, [unk] choline, free choline, and betaine; label also accumulated slowly in phosphatidylcholine. Phosphatidylcholines 206-225 membrane metalloendopeptidase Homo sapiens 18-21 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 84-103 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 84-103 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 84-103 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 unk zinc finger Homo sapiens 28-31 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 membrane metalloendopeptidase Homo sapiens 198-201 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 unk zinc finger Homo sapiens 193-196 16662890-7 1983 Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME -->[unk] DME --> [unk] choline --> choline --> --> betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine. Phosphatidylcholines 334-353 unk zinc finger Homo sapiens 193-196 6337128-1 1983 The Saccharomyces cerevisiae opi3-3 mutant was shown to be defective in the synthesis of phosphatidylcholine via methylation of phosphatidylethanolamine. Phosphatidylcholines 89-108 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 29-35 6860684-0 1983 Transfer of cholesteryl linoleyl ether from phosphatidylcholine and phosphatidylethanolamine liposomes to cultured cells catalyzed by lipoprotein lipase. Phosphatidylcholines 44-63 lipoprotein lipase Homo sapiens 134-152 6337128-5 1983 When grown in the absence of exogenous choline, the opi3-3 mutant had a phospholipid composition consisting of 2 to 3% phosphatidylcholine compared with 40 to 50% in wild-type strains. Phosphatidylcholines 119-138 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 52-58 6337128-11 1983 Based upon incorporation of choline into phosphatidylcholine, it is concluded that the opi3-3 mutant has no defect in the synthesis of phosphatidylcholine from exogenous choline. Phosphatidylcholines 41-60 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 87-93 6297895-1 1983 Interactions of band 4.1 with mixed phospholipid membranes [phosphatidylserine (PtdSer), phosphatidylethanolamine, phosphatidylcholine, etc.] Phosphatidylcholines 115-134 erythrocyte membrane protein band 4.1 Homo sapiens 16-24 6401716-7 1983 It is concluded that the mechanisms of interaction between apolipoprotein A-I and either bovine brain sphingomyelin or phosphatidylcholines are similar, but that the nature of the protein-lipid interactions with BBSM are such as to produce larger and more stable complexes than are observed with the phosphatidylcholines. Phosphatidylcholines 119-139 APOAI Bos taurus 59-77 6297604-5 1983 Exposure of isolated type II cells to the phospholipase A2 inhibitors 4-bromophenacylbromide or quinacrine dihydrochloride led to a decreased synthesis of total phosphatidylcholines from various labelled precursors. Phosphatidylcholines 161-181 phospholipase A2 group IB Rattus norvegicus 42-58 6850989-5 1983 Cytochrome P-450 was phosphorylated when added as sole component and also when in the presence of P-450 reductase and phosphatidylcholine. Phosphatidylcholines 118-137 cytochrome P-450 Oryctolagus cuniculus 0-16 6684464-3 1983 --This radioactivity is detected by the labelling of phosphatidyl-choline and endogenous sphingomyelin from CDP-choline. Phosphatidylcholines 53-73 cut-like homeobox 1 Rattus norvegicus 108-111 6129245-1 1982 The membrane-permeable photoactivatable reagent 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine was used to selectively label the hydrophobic domain of the amphipathic form of gamma-glutamyl transpeptidase reconstituted into phosphatidylcholine vesicles. Phosphatidylcholines 227-246 gamma-glutamyltransferase 1 Rattus norvegicus 178-207 6831908-2 1983 Bee venom phospholipase A2 which attacks only phosphatidylcholine (PC) in the intact erythrocyte results in inhibition of cryohemolysis produced by both hypertonic sodium chloride and sucrose. Phosphatidylcholines 46-65 phospholipase A2 group IB Homo sapiens 10-26 6831908-2 1983 Bee venom phospholipase A2 which attacks only phosphatidylcholine (PC) in the intact erythrocyte results in inhibition of cryohemolysis produced by both hypertonic sodium chloride and sucrose. Phosphatidylcholines 67-69 phospholipase A2 group IB Homo sapiens 10-26 7150628-2 1982 Phosphatidylcholines and phosphatidylethanolamines with an oleoyl or a docosahexaenoyl residue at C-2 increased, while many of the species with a linoleoyl or an arachidonoyl residue at C-2 decreased throughout the experiment. Phosphatidylcholines 0-20 complement C2 Rattus norvegicus 98-101 6761591-2 1982 Lysolecithin, one of the hydrolytic products of phosphatidyl choline by phospholipase A was prepared and found able to hemolyse human red blood cells and "clear" rat skin and muscle homogenates. Phosphatidylcholines 48-68 phospholipase A and acyltransferase 1 Homo sapiens 72-87 6818987-1 1982 Micellar complexes with different phosphatidylcholine (PC) compositions were prepared by the dialysis of PC-cholesterol dispersions with cholate in the presence of human apolipoprotein A-I (apo A-I). Phosphatidylcholines 55-57 apolipoprotein A1 Homo sapiens 170-188 7150631-2 1982 The lipoprotein lipase-catalyzed hydrolysis of triacylglycerol was determined in a lipid monolayer containing egg phosphatidylcholine and tri[14C]oleoylglycerol. Phosphatidylcholines 114-133 lipoprotein lipase Bos taurus 4-22 7150631-6 1982 The addition of sphingomyelin to the phosphatidylcholine monolayer decreased lipoprotein lipase activity. Phosphatidylcholines 37-56 lipoprotein lipase Bos taurus 77-95 6130787-2 1982 We show that the binding constant for cholesterol is considerably less than that for phosphatidylcholine, so that cholesterol is effectively excluded from the phospholipid annulus around the ATPase. Phosphatidylcholines 85-104 dynein axonemal heavy chain 8 Homo sapiens 191-197 6817809-3 1982 In vitro, the association of apolipoprotein A-I with physiological phosphatidylcholines can be catalyzed by mixing the protein and lipid with sodium cholate, which is removed by chromatography. Phosphatidylcholines 67-87 apolipoprotein A1 Homo sapiens 29-47 7165723-10 1982 This stimulation of acidic phospholipase A activity by chloroquine appears to be coupled to the synthesis of disaturated phosphatidylcholine, thereby enhancing remodelling of phosphatidylcholine synthesized de novo. Phosphatidylcholines 121-140 phospholipase A and acyltransferase 1 Rattus norvegicus 27-42 6219744-5 1982 Potency of anti-CaM drugs was generally greater on the enzyme reconstituted in asolectin vesicles than on the enzyme reconstituted in phosphatidylcholine vesicles, either in the presence or absence of CaM. Phosphatidylcholines 134-153 calmodulin 1 Homo sapiens 16-19 7159628-0 1982 [Rapid transmembrane migration of phosphatidylcholine under the influence of cytochrome P-450]. Phosphatidylcholines 34-53 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 77-94 7142994-3 1982 NGF stimulates the incorporation of 32PO4 into other lipids, such as phosphatidylcholine, to a lesser extent. Phosphatidylcholines 69-88 nerve growth factor Homo sapiens 0-3 7159628-1 1982 The phosphatidylcholine exchange protein and bee venom phospholipase A2 were used to estimate the phosphatidylcholine accessibility in proteoliposome-containing cytochrome P-450. Phosphatidylcholines 4-23 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 161-177 7159628-3 1982 Incorporation of cytochrome P-450 into the liposomes resulted in a complete accessibility of phosphatidylcholine for the phosphatidylcholine exchange protein and phospholipase A2. Phosphatidylcholines 93-112 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 17-33 7159628-3 1982 Incorporation of cytochrome P-450 into the liposomes resulted in a complete accessibility of phosphatidylcholine for the phosphatidylcholine exchange protein and phospholipase A2. Phosphatidylcholines 93-112 phospholipase A2 group IB Rattus norvegicus 162-178 7159628-5 1982 It was concluded that cytochrome P-450 induces rapid transmembrane translocation of phosphatidylcholine with tau 1/2 less than 20 min. Phosphatidylcholines 84-103 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 22-38 7159628-6 1982 It is proposed that cytochrome P-450 may be responsible for rapid flip-flop of phosphatidylcholine in rat liver microsomes. Phosphatidylcholines 79-98 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-36 7160029-6 1982 In contrast to these two proteins, the presence of synexin in the solution did enhance the Ca2+-induced aggregation of phosphatidylserine vesicles, but did not seem to affect the degree of Ca2+-induced fusion between phosphatidylserine/phosphatidylcholine (1:1) and phosphatidylserine vesicles and monolayer membranes. Phosphatidylcholines 236-255 annexin A7 Homo sapiens 51-58 6295447-1 1982 Rotational diffusion of rhodopsin in reconstituted membranes of phosphatidylcholines of various alkyl chain lengths has been measured by using saturation-transfer electron spin resonance spectroscopy as a function of temperature and lipid/rhodopsin mole ratio. Phosphatidylcholines 64-84 rhodopsin Homo sapiens 24-33 27519437-10 1982 It appears that microsomal glucose-6-phosphatase is inhibited by increased phosphatidylcholine saturation. Phosphatidylcholines 75-94 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 27-48 6818955-0 1982 Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes. Phosphatidylcholines 14-33 arginine vasopressin Rattus norvegicus 47-58 6818955-1 1982 The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. Phosphatidylcholines 169-188 arginine vasopressin Rattus norvegicus 25-36 7171594-1 1982 Glycophorin A, the major sialoglycoprotein of the human erythrocyte membrane, has been incorporated in small unilamellar vesicles containing phosphatidylcholine and phosphatidylethanolamine in varying proportions. Phosphatidylcholines 141-160 glycophorin A (MNS blood group) Homo sapiens 0-13 6819423-5 1982 Radioactivity of phosphatidylcholine (2-arachidonyl-1-14C) suspended in the plasma of PRP was incorporated into 12-HETE but not to TXB2, indicating again that only lipoxygenase can utilize AA derived from plasma phospholipids. Phosphatidylcholines 17-36 proline rich protein 2-like 1 Rattus norvegicus 86-89 6185153-11 1982 The reduced synthesis of phosphatidylcholine strongly correlated with inhibition of CTP:phosphocholine cytidylyltransferase activity. Phosphatidylcholines 25-44 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 84-123 7181862-2 1982 We have found, however, that the activity of microsomal glutathione S-transferase is increased 5-fold after treatment with small unilamellar vesicles made from phosphatidylcholine. Phosphatidylcholines 160-179 hematopoietic prostaglandin D synthase Rattus norvegicus 56-81 7181862-5 1982 When this fraction of the microsomal extract is reconstituted in the form of small unilamellar vesicles, it inhibits microsomal glutathione S-transferase that had been activated by prior treatment with small unilamellar vesicles of pure phosphatidylcholine, but does not affect the activity of unactivated microsomal glutathione S-transferase. Phosphatidylcholines 237-256 hematopoietic prostaglandin D synthase Rattus norvegicus 128-153 7142127-10 1982 It catalyzed benzo(a)pyrene hydroxylation with a turnover rate of 3.63 nmol/nmol of cytochrome P-450 in a reconstituted system containing NADPH-cytochrome c reductase and phosphatidylcholine, whereas little myristate hydroxylation activity was detected. Phosphatidylcholines 171-190 cytochrome P-450 Oryctolagus cuniculus 84-100 7139847-2 1982 Furthermore, it was found that at the phase transition temperature the phosphatidylcholine bilayers are subject to rapid hydrolysis by pancreatic phospholipase A2 whereas phosphatidylethanolamine bilayers are not. Phosphatidylcholines 71-90 phospholipase A2 group IB Homo sapiens 146-162 6286659-2 1982 Binding of human fibroblast beta-hexosaminidase B to receptors reconstituted into phosphatidylcholine liposomes was 1) specifically inhibited by mannose 6-phosphate, but not mannose 1-phosphate or glucose 6-phosphate, and 2) had properties similar to the previously reported binding of enzyme to receptors on cell surfaces and isolated membranes. Phosphatidylcholines 82-101 O-GlcNAcase Homo sapiens 28-47 7126623-2 1982 [3H]Cholesteryl esters were formed by endogenous HDL3/VHDL enzyme (d greater than 1.125 g/ml) following incubation with mixed vesicles of phosphatidylcholine, unesterified cholesterol and 3H-labelled unesterified cholesterol. Phosphatidylcholines 138-157 HDL3 Homo sapiens 49-53 7126704-0 1982 [Lipid dependence of the activity of cytochrome P-450 from microsomes of rat liver by the phosphatidylcholine transfer protein from bovine liver]. Phosphatidylcholines 90-109 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 37-53 7142817-1 1982 Phosphatidylcholine synthesis from CDP-[methyl-14C]choline and membrane-bound diacyl-[U-14C]-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 35-38 7126704-1 1982 The lipid dependence of hydroxylase and demethylase activities of microsomal cytochrome P-450 was studied, using purified phosphatidylcholine transfer protein from bovine liver. Phosphatidylcholines 122-141 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 77-93 7126704-2 1982 In the presence of this protein exogeneous phosphatidylcholine was shown to reactivate cytochrome P-450 inactivated earlier with lysophosphatidylcholine. Phosphatidylcholines 43-62 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 87-103 6214785-5 1982 This effect of synexin was drastically inhibited by including 25% phosphatidylcholine (mol/mol) in the vesicle membrane. Phosphatidylcholines 66-85 annexin A7 Homo sapiens 15-22 7076675-0 1982 Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathway. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 129-132 6126513-3 1982 When this microsomal extract was combined with liposomes composed of cholesterol and egg phosphatidylcholine, the ACAT activity increased 5.4- to 6.7-fold. Phosphatidylcholines 89-108 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 114-118 6126513-5 1982 ACAT activity increased 2.9-fold when the phosphatidylcholine content of the liposomes was raised from 0.5 to 5.0 mumol/mg microsomal protein. Phosphatidylcholines 42-61 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-4 6126513-8 1982 ACAT activity was five times higher when the liposomes were prepared from dioleoylphosphatidylcholine than from saturated phosphatidylcholines, including hydrogenated egg yolk, dimyristoyl or dipalmitoyl phosphatidylcholine. Phosphatidylcholines 122-142 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-4 6126513-9 1982 Likewise, the ACAT activity with liposomes made from soybean or egg yolk phosphatidylcholine was almost 3.5-fold greater than with those prepared from the saturated phosphatidylcholines. Phosphatidylcholines 73-92 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 14-18 6126513-9 1982 Likewise, the ACAT activity with liposomes made from soybean or egg yolk phosphatidylcholine was almost 3.5-fold greater than with those prepared from the saturated phosphatidylcholines. Phosphatidylcholines 165-185 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 14-18 6806255-1 1982 Mouse peritoneal macrophages have a phospholipase A2 activity which is optimally active at pH 8.5 (PLA8.5), requires 2 mM Ca2+ and is capable of hydrolyzing arachidonic acid from phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 179-198 phospholipase A2, group IB, pancreas Mus musculus 36-52 6810941-5 1982 The binding of 125I-labeled HDL3 to the rat liver plasma membranes was competitively inhibited by unlabeled human HDL3, rat HDL, HDL from nephrotic rats enriched in apolipoprotein A-I and phosphatidylcholine complexes of human apolipoprotein A-I, but not by human or rat LDL, free human apolipoprotein A-I or phosphatidylcholine vesicles. Phosphatidylcholines 188-207 HDL3 Homo sapiens 28-32 6810941-6 1982 Human 125I-labeled apolipoprotein A-I complexed with egg phosphatidylcholine bound to rat liver plasma membranes with high affinity and saturability, and the binding constants were similar to those of human 125I-labeled HDL3. Phosphatidylcholines 57-76 apolipoprotein A1 Homo sapiens 19-37 6810947-8 1982 Deoxycholate also induces slightly the disappearance of some 14C radioactivity from phosphatidylethanolamine and phosphatidylcholine, which might reflect activation of phospholipase A2. Phosphatidylcholines 113-132 phospholipase A2 group IB Rattus norvegicus 168-184 7091020-6 1982 Concentrations of 20 to 22 carbon polyunsaturated fatty acids in the erythrocyte membrane phosphatidylethanolamine and phosphatidylcholine of SMA and Enfamil-fed infants were similar despite very significant differences in the amount of dietary 18 carbon precursor. Phosphatidylcholines 119-138 survival of motor neuron 1, telomeric Homo sapiens 142-145 7085608-4 1982 Elevated platelet cholesterol content affected thrombin-induced changes in platelet phospholipids: (a) hydrolysis of PC was more sensitive to thrombin and was markedly enhanced over a wide range of thrombin concentrations (0.1-2 units/ml); (b) hydrolysis of phosphatidylinositol (PI) was increased at thrombin concentrations greater than or equal to 0.2 unit/ml. Phosphatidylcholines 117-119 coagulation factor II, thrombin Homo sapiens 47-55 7085608-6 1982 At higher thrombin concentrations (0.2-2 units/ml) it reflected enhanced hydrolysis of predominantly PC, but also PI. Phosphatidylcholines 101-103 coagulation factor II, thrombin Homo sapiens 10-18 6809043-1 1982 Effect of apolipoprotein A-I on phosphatidylcholine polar group conformation as studied by proton nuclear magnetic resonance. Phosphatidylcholines 32-51 apolipoprotein A1 Homo sapiens 10-28 7136004-10 1982 Alterations in hepatic drug metabolism are possibly mediated via changes in microsomal phospholipids and/or the cytochrome P-450 spin-state equilibrium as as pregnancy was associated with a decrease in (a) microsomal total phospholipids, (b) the phosphatidylcholine to phosphatidylethanolamine ratio and (c) the high-spin form of ferricytochrome P-450. Phosphatidylcholines 246-265 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-128 7104306-5 1982 The half-time for dipalmitoyl-PC exchange from HDL3 to LDL is 5 +/- h, indicating that the flux of PC is much lower than that of cholesterol. Phosphatidylcholines 30-32 HDL3 Homo sapiens 47-51 7093220-3 1982 The addition of [3H]methionine to cells that were grown in 1 mM dimethylethanolamine efficiently radiolabeled phosphatidylcholine (by methylation of phosphatidyldimethylethanolamine) and sphingomyelin but not phosphocholine or CDP-choline. Phosphatidylcholines 110-129 cut like homeobox 1 Homo sapiens 227-230 6802836-0 1982 Reaction of human lecithin cholesterol acyltransferase with synthetic micellar complexes of apolipoprotein A-I, phosphatidylcholine, and cholesterol. Phosphatidylcholines 112-131 lecithin-cholesterol acyltransferase Homo sapiens 18-54 6802835-0 1982 Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions. Phosphatidylcholines 52-72 apolipoprotein A1 Homo sapiens 28-46 6802836-1 1982 Micellar, discoidal complexes of human apolipoprotein A-I (apo A-I) with phosphatidylcholines and cholesterol, prepared by the method described in the preceding paper (Matz, C. M., and Jonas, A. Phosphatidylcholines 73-93 apolipoprotein A1 Homo sapiens 39-57 6802836-1 1982 Micellar, discoidal complexes of human apolipoprotein A-I (apo A-I) with phosphatidylcholines and cholesterol, prepared by the method described in the preceding paper (Matz, C. M., and Jonas, A. Phosphatidylcholines 73-93 apolipoprotein A1 Homo sapiens 59-66 6275924-5 1982 For the phosphatidylcholine spin label there are effectively 55 +/- 5 lipids/200,000-dalton cytochrome oxidase, 58 +/- 4 mol lipid/265,000 dalton (Na+, K+)-ATPase, and 24 +/- 3 and 22 +/- 2 mol lipid/37,000 dalton rhodopsin for the bovine and frog preparations, respectively. Phosphatidylcholines 8-27 rhodopsin Bos taurus 214-223 7061453-0 1982 Kinetics of the incorporation of adrenal cytochrome P-450scc into phosphatidylcholine vesicles. Phosphatidylcholines 66-85 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 41-60 6799515-9 1982 These results suggest that the CoA-mediated, ATP-independent breakdown of phosphatidylcholine and transfer of arachidonic acid is catalyzed by the acyl-CoA:lysophosphatide acyltransferase operating in reverse. Phosphatidylcholines 74-93 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 31-34 6799515-9 1982 These results suggest that the CoA-mediated, ATP-independent breakdown of phosphatidylcholine and transfer of arachidonic acid is catalyzed by the acyl-CoA:lysophosphatide acyltransferase operating in reverse. Phosphatidylcholines 74-93 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 152-155 7087686-3 1982 In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was labeled in the 2-position with [1-14C] oleic acid. Phosphatidylcholines 123-142 LOC104974671 Bos taurus 50-66 7087686-3 1982 In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was labeled in the 2-position with [1-14C] oleic acid. Phosphatidylcholines 144-146 LOC104974671 Bos taurus 50-66 7074076-4 1982 At 37 degrees C and an internal concentration of 30 mM Ca2+, the initial flux for rhodopsin-egg phosphatidylcholine membrane vesicles was 0.25 +/- 0.11 Ca2+ per bleached rhodopsin per s. Similar fluxes were observed for the release of Co2+, Mn2+, Ni2+, and Mg2+. Phosphatidylcholines 96-115 rhodopsin Homo sapiens 82-91 7074076-4 1982 At 37 degrees C and an internal concentration of 30 mM Ca2+, the initial flux for rhodopsin-egg phosphatidylcholine membrane vesicles was 0.25 +/- 0.11 Ca2+ per bleached rhodopsin per s. Similar fluxes were observed for the release of Co2+, Mn2+, Ni2+, and Mg2+. Phosphatidylcholines 96-115 rhodopsin Homo sapiens 170-179 6799515-6 1982 Addition of CoA and lysophosphatidylethanolamine to prelabeled thymocyte homogenates induced a fast breakdown of phosphatidylcholine and transfer of arachidonic acid to phosphatidylethanolamine, as in seen during incubations of intact thymocytes or macrophages. Phosphatidylcholines 113-132 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 12-15 6804944-3 1982 The isolated IgG-binding proteins specifically bound to IgG2a, but not to IgG2b, whereas the isolated phosphatidylcholine-binding proteins specifically bound to IgG2b but not to IgG2a. Phosphatidylcholines 102-121 immunoglobulin heavy constant gamma 2B Mus musculus 161-166 6807835-3 1982 Phospholipase A2 digestion of the intact erythrocytes resulted in a diminution of exclusively phosphatidylcholine (PC) from the membrane, and an approximately parallel loss of Rh antigen activity at 37 degrees to about 50% of the original. Phosphatidylcholines 94-113 phospholipase A2 group IB Homo sapiens 0-16 6807835-3 1982 Phospholipase A2 digestion of the intact erythrocytes resulted in a diminution of exclusively phosphatidylcholine (PC) from the membrane, and an approximately parallel loss of Rh antigen activity at 37 degrees to about 50% of the original. Phosphatidylcholines 115-117 phospholipase A2 group IB Homo sapiens 0-16 6188759-1 1982 The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells. Phosphatidylcholines 103-122 interferon alpha 1 Homo sapiens 20-36 6188759-1 1982 The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells. Phosphatidylcholines 124-126 interferon alpha 1 Homo sapiens 20-36 6188759-2 1982 An inhibition of the synthesis of PC via this pathway was regularly observed with both alpha- (recombinant or natural) and beta-IFN. Phosphatidylcholines 34-36 interferon alpha 1 Homo sapiens 128-131 7070579-1 1982 The phospholipid composition and the in vitro incorporation of radioactive CDP-choline into phosphatidylcholine was studied in mitochondria and microsomal fraction obtained from liver and brain of 20 day old hyperthyroid or hypothyroid rats. Phosphatidylcholines 92-111 cut-like homeobox 1 Rattus norvegicus 75-78 6804944-4 1982 Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine. Phosphatidylcholines 0-19 phospholipase A2, group IB, pancreas Mus musculus 57-73 6804944-4 1982 Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine. Phosphatidylcholines 300-319 phospholipase A2, group IB, pancreas Mus musculus 57-73 6804944-5 1982 The noted enzymatic activity was augmented 4-fold by preincubating phosphatidylcholine-binding proteins with heat-aggregated murine IgG2b but not with IgG2a. Phosphatidylcholines 67-86 immunoglobulin heavy constant gamma 2B Mus musculus 132-137 6273120-2 1981 During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and incorporation of [3H]glycerol and [14C]palmitate into phosphatidylcholine and phosphatidylethanolamine, two major phospholipids which are derived from phosphatidic acid, but are extrinsic to the inositide pathway. Phosphatidylcholines 161-180 proopiomelanocortin Homo sapiens 57-61 7146568-5 1982 There was also observed a marked increase in specific radioactivity of sphingomyelin, which could be due to a stimulation of CDP-choline: ceramide cholinephosphotransferase reaction with subsequent diminution of the rate of phosphatidylcholine synthesis via the CDP-amine pathway (involving cytidine diphosphocholine). Phosphatidylcholines 224-243 cut-like homeobox 1 Rattus norvegicus 125-128 6275886-11 1981 The rate of phosphatidylcholine synthesis measured from incorporation of di[1-14C]palmitoyl glycerol equalled that observed with labeled CDP choline. Phosphatidylcholines 12-31 cut-like homeobox 1 Rattus norvegicus 137-140 6273120-4 1981 Similar to previously reported effects on phosphatidic acid and inositide phospholipids, cycloheximide blocked the effects of ACTH and cAMP on phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 143-162 proopiomelanocortin Homo sapiens 126-130 6271752-3 1981 Following reconstitution into phosphatidylcholine vesicles, the channel regained 125I-ScTX binding and thermal stability of [3H]STX binding. Phosphatidylcholines 30-49 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Rattus norvegicus 128-131 7299128-6 1981 FcR gamma is also induced on approximately 40% of M1- cells by incubating cells with cholesterol-phosphatidyl-choline liposomes with the concomitant increase of their membrane microviscosity. Phosphatidylcholines 97-117 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 0-9 7309711-2 1981 Fatty acid omega- and (omega-1)-hydroxylation activity was reconstituted from the partially purified cytochrome P-450 and NADPH-cytochrome c reductase, with phosphatidylethanolamine or phosphatidylcholine. Phosphatidylcholines 185-204 cytochrome P-450 Oryctolagus cuniculus 101-117 6803776-2 1981 Affinity chromatography-purified and non-purified rabbit immunoglobulin G (IgG) raised against human immunoglobulin M (IgM) or kappa chain was incorporated into carboxyfluorescein-containing small unilamellar liposomes composed of egg phosphatidylcholine, cholesterol and phosphatidic acid (molar proportions 7:7:1). Phosphatidylcholines 235-254 immunoglobulin heavy variable V1-62 Mus musculus 75-78 7338519-2 1981 Liposomes composed of phosphatidylcholine and stearylamine were agglutinated with CRP. Phosphatidylcholines 22-41 C-reactive protein Homo sapiens 82-85 7338519-5 1981 Agglutination of liposomes caused by CRP was dependent on the fatty acid composition of phosphatidylcholine, cholesterol content and temperature. Phosphatidylcholines 88-107 C-reactive protein Homo sapiens 37-40 6121556-4 1981 By using this method, microvillus aminopeptidase was inserted almost quantitatively into either phosphatidylcholine vesicles or microvillus-lipid vesicles. Phosphatidylcholines 96-115 alanyl aminopeptidase, membrane Sus scrofa 34-48 6796129-2 1981 The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in 0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7). Phosphatidylcholines 86-105 cytochrome c oxidase subunit 8A Homo sapiens 22-26 6796129-2 1981 The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in 0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7). Phosphatidylcholines 107-109 cytochrome c oxidase subunit 8A Homo sapiens 22-26 7306536-1 1981 Previous studies have revealed that the replacement of the C-2 ester group in phosphatidylcholine by the carbamyloxy function renders the resulting lipids, without affecting the properties of the liposomes, resistant to hydrolysis by phospholipase A2 (Gupta, C.M. Phosphatidylcholines 78-97 phospholipase A2 group IB Homo sapiens 234-250 7311737-0 1981 Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase. Phosphatidylcholines 25-44 phospholipase A2 group IB Homo sapiens 48-64 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 37-56 Bardet-Biedl syndrome 9 Homo sapiens 29-32 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-6 1981 The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine. Phosphatidylcholines 77-96 Bardet-Biedl syndrome 9 Homo sapiens 70-73 6895326-8 1981 The inclusion of 40 mol% cholesterol in C16 : 0 phosphatidylcholine and C18 : 0 phosphatidylcholine liposomes made these vesicles sensitive to streptolysin S. Egg phosphatidylcholine liposomes, which were unaffected at 0 degrees C and 4 degrees C became susceptible to the toxin at these temperatures when cholesterol was included. Phosphatidylcholines 80-99 Bardet-Biedl syndrome 9 Homo sapiens 72-75 6895326-8 1981 The inclusion of 40 mol% cholesterol in C16 : 0 phosphatidylcholine and C18 : 0 phosphatidylcholine liposomes made these vesicles sensitive to streptolysin S. Egg phosphatidylcholine liposomes, which were unaffected at 0 degrees C and 4 degrees C became susceptible to the toxin at these temperatures when cholesterol was included. Phosphatidylcholines 80-99 Bardet-Biedl syndrome 9 Homo sapiens 72-75 7295746-1 1981 In this study we have determined the effects of two commercial albumin preparations (Sigma and Pentex albumins) and two detergents (sodium deoxycholate and Triton X-100) on the activity of lipoprotein lipase purified from bovine milk against biosynthetically labeled triacylglycerol in very low density lipoprotein and biosynthetically labeled phosphatidylcholine in very low density and high density lipoproteins. Phosphatidylcholines 344-363 lipoprotein lipase Bos taurus 189-207 7263710-10 1981 Phosphatidylcholine might reassociate as the membrane fluid bilayer, which in turn modulated the monoamine oxidase A activity. Phosphatidylcholines 0-19 monoamine oxidase A Homo sapiens 97-116 7289798-6 1981 Phospholipase A2 action on phosphatidylcholine and phosphatidylethanolamine demonstrated enrichment of the c,c- and the c,t-18:2 products in the 2-position, whereas the 18:1 substrates were preferentially inserted into the 1-positions. Phosphatidylcholines 27-46 phospholipase A2 group IB Rattus norvegicus 0-16 6167576-1 1981 The effect of cAMP analogues on phosphatidylcholine formation via the CDP-choline pathway was investigated in cultured monolayers of rat hepatocytes. Phosphatidylcholines 32-51 cut-like homeobox 1 Rattus norvegicus 70-73 7264659-3 1981 In Trembler cells, cultivated in the presence of labelled acetate, the fatty acids were slightly altered; phosphatidylcholine was slightly reduced and phosphatidylethanolamine increased. Phosphatidylcholines 106-125 peripheral myelin protein 22 Mus musculus 3-11 7019229-5 1981 Cortisol (0.2 micrograms/ml) plus PRL (2.5 micrograms/ml), when added to the medium from the beginning of the culture period, caused a 2- to 3-fold increase in the rate of choline incorporation into phosphatidylcholine, as measured on the second, fourth, sixth, and eighth days of incubation, as well as an increase in the phosphatidylcholine content of the explants. Phosphatidylcholines 199-218 prolactin Homo sapiens 34-37 7019229-5 1981 Cortisol (0.2 micrograms/ml) plus PRL (2.5 micrograms/ml), when added to the medium from the beginning of the culture period, caused a 2- to 3-fold increase in the rate of choline incorporation into phosphatidylcholine, as measured on the second, fourth, sixth, and eighth days of incubation, as well as an increase in the phosphatidylcholine content of the explants. Phosphatidylcholines 323-342 prolactin Homo sapiens 34-37 7019229-9 1981 Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination. Phosphatidylcholines 13-32 insulin Homo sapiens 116-123 7019229-9 1981 Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination. Phosphatidylcholines 13-32 prolactin Homo sapiens 159-162 7019229-9 1981 Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination. Phosphatidylcholines 13-32 insulin Homo sapiens 186-193 6269639-0 1981 Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth. Phosphatidylcholines 99-118 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 34-37 7314059-0 1981 Enhancement of thrombin-induced degradation of phosphatidylcholine in reserpinized rabbit platelets. Phosphatidylcholines 47-66 prothrombin Oryctolagus cuniculus 15-23 7314059-3 1981 TLC analysis revealed that the stimulation of the decrease in radioactivity of phospholipids was almost exclusively attributed to that of phosphatidylcholine (PC), and that thrombin induced a slight but significant increase in radioactivity of phosphatidylethanolamine (PE) in the reserpinized platelets. Phosphatidylcholines 159-161 prothrombin Oryctolagus cuniculus 173-181 7314059-4 1981 The results suggest that thrombin-induced degradation of PC is enhanced in the reserpinized platelets, and the overproduced fatty acids would be metabolized to the larger amount of oxygenated products which result in the activation of the platelets. Phosphatidylcholines 57-59 prothrombin Oryctolagus cuniculus 25-33 7314059-5 1981 Thrombin-induced mobilization of PC to PE in the reserpinized platelet phospholipids was also suggested. Phosphatidylcholines 33-35 prothrombin Oryctolagus cuniculus 0-8 6943585-8 1981 Peripheral blood mononuclear cells were also directly shown to display phospholipase A2-like activity, as measured by the decrease in radioactive arachidonate from prelabeled phospholipids, specifically phosphatidylcholine, in effector cells. Phosphatidylcholines 203-222 phospholipase A2 group IB Homo sapiens 71-87 6973491-0 1981 CoA-dependent cleavage of arachidonic acid from phosphatidylcholine and transfer to phosphatidylethanolamine in homogenates of murine thymocytes. Phosphatidylcholines 48-67 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 0-3 6791934-3 1981 Incubation in vitro of VLDL with the lipase caused hydrolysis of VLDL-triglycerides (greater than 80%) and VLDL-phosphatidylcholine (greater than 30%). Phosphatidylcholines 112-131 lipase G, endothelial type Rattus norvegicus 37-43 6272753-11 1981 These results provide good evidence that the rate-limiting step for phosphatidylcholine biosynthesis in these cultured hepatocytes is the conversion of phosphocholine into CDP-choline. Phosphatidylcholines 68-87 cut-like homeobox 1 Rattus norvegicus 172-175 6264965-11 1981 We propose that a principal pathway for degradation of phosphatidylcholine, particularly during brain ischemia, is by reversal of cholinephosphotransferase, followed by hydrolysis of diacylglycerols by the lipase. Phosphatidylcholines 55-74 lipase G, endothelial type Rattus norvegicus 206-212 6164508-1 1981 Hydrophobic compounds influenced the accuracy of the radioimmunoassay for myelin basic protein when lipids (stearic acid, phosphatidylcholine, cholesterol, cerebroside, sulfatide, or GM1 ganglioside) or proteolipids (white-matter proteolipid apoprotein, kidney proteolipid apoproteins, or heart proteolipid apoproteins) were added to a known amount of basic protein and the samples assayed. Phosphatidylcholines 122-141 myelin basic protein Homo sapiens 74-94 7217669-0 1981 Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement. Phosphatidylcholines 50-69 C-reactive protein Homo sapiens 15-33 7217669-2 1981 Binding of CRP to multilamellar liposomes or unilamellar vesicles of egg-phosphatidylcholine required the presence of lysophosphatide in the bilayer. Phosphatidylcholines 73-92 C-reactive protein Homo sapiens 11-14 7217669-5 1981 In addition, incorporation of galactocyl cerebroside in phosphatidylcholine:lysophosphatidylcholine liposomes enhanced the binding of CRP. Phosphatidylcholines 56-75 C-reactive protein Homo sapiens 134-137 6257500-2 1981 CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcholine (PC). Phosphatidylcholines 110-129 carboxyl ester lipase Rattus norvegicus 0-5 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 192-211 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-151 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 192-211 phosphatidylethanolamine N-methyltransferase Homo sapiens 153-157 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 213-215 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-151 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 213-215 phosphatidylethanolamine N-methyltransferase Homo sapiens 153-157 6452902-5 1981 In parallel with the lipid binding studies, we have measured the sensitivity of the catalytic activity of the Ca2+ ATPase to the fatty acyl chain characteristics of the phosphatidylcholine membranes in which the enzyme was reconstituted. Phosphatidylcholines 169-188 carbonic anhydrase 2 Oryctolagus cuniculus 110-121 6452452-10 1981 With vesicles containing a mixture of phosphatidylserine with phosphatidylcholine, synexin enhances aggregation in the presence of CA2+, without promoting fusion. Phosphatidylcholines 62-81 annexin A7 Homo sapiens 83-90 7284359-4 1981 Differential scanning calorimetry experiments show a miscibility of alk(en)yl resorcinols with phosphatidylcholines. Phosphatidylcholines 95-115 ALK receptor tyrosine kinase Homo sapiens 68-71 6111345-1 1981 The activities of purified (Na+ + K+)-ATPase supported by a series of phosphatidylcholines with monounsaturated (cis-9) fatty acyl chains (di(n : 1) phosphatidylcholine) varying in length from n = 12 to n = 23 were determined by the lipid titration technique. Phosphatidylcholines 70-90 dynein axonemal heavy chain 8 Homo sapiens 38-44 6779878-10 1981 Thrombin also decreased the synthesis of phosphatidylcholine when choline was used as the radiolabeled substrate. Phosphatidylcholines 41-60 coagulation factor II, thrombin Homo sapiens 0-8 6257500-2 1981 CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcholine (PC). Phosphatidylcholines 131-133 carboxyl ester lipase Rattus norvegicus 0-5 6257500-5 1981 Both acid and alkaline CEase activities were markedly enhanced by increasing the concentration of PC, but not by phospholipids. Phosphatidylcholines 98-100 carboxyl ester lipase Rattus norvegicus 23-28 6257500-8 1981 Increases in both acid and alkaline CEase activities were observed in adrenal homogenates prepared from hypophysectomized rats treated with an iv injection of ACTH when the molar ratio of cholesteryl oleate to PC used as a substrate vesicle was 1:0.2, but not when the ratio was 1:2. Phosphatidylcholines 210-212 carboxyl ester lipase Rattus norvegicus 36-41 7462211-4 1981 Decreases in phosphatidylcholine and also phosphatidylethanolamine occur within 20 s after stimulation of platelets by thrombin. Phosphatidylcholines 13-32 coagulation factor II, thrombin Homo sapiens 119-127 6257695-4 1981 Thermal transitions were detected in Arrhenius plots of 5"-nucleotidase after detergent solubilization, in the membranes which contained the three phospholipids, but not in the purified fraction which contained only sphingomyelin; transitions were also detected after reassociation of the purified enzyme with microsomal or plasma membrane lipids and phosphatidylcholine but not with phosphatidylethanolamine. Phosphatidylcholines 351-370 5' nucleotidase, ecto Rattus norvegicus 56-71 6257695-5 1981 Phosphatidylcholines containing specific fatty acids all affected the energy of activation of 5"-nucleotidase, and the detergent Sarkosyl, which has been shown to dissociate phospholipids from 5"-nucleotidase (Evans, W. H., and Gurd, J. W. (1973) Biochem. Phosphatidylcholines 0-20 5' nucleotidase, ecto Rattus norvegicus 94-109 6257695-5 1981 Phosphatidylcholines containing specific fatty acids all affected the energy of activation of 5"-nucleotidase, and the detergent Sarkosyl, which has been shown to dissociate phospholipids from 5"-nucleotidase (Evans, W. H., and Gurd, J. W. (1973) Biochem. Phosphatidylcholines 0-20 5' nucleotidase, ecto Rattus norvegicus 193-208 7213783-2 1981 A novel class of phospholipase-resisting phosphatidylcholine analogs, in which the C-2 ester group or both C-1 and C-2 ester groups have been replaced by carbomyloxy functions (Formula--see text), have been synthesized. Phosphatidylcholines 41-60 heterogeneous nuclear ribonucleoprotein C Homo sapiens 107-118 6257695-9 1981 It is concluded that in situ, 5"-nucleotidase interacts with both sphingomyelin and phosphatidylcholine; the first apparently influences the stability of the enzyme and the second, the energy of activation. Phosphatidylcholines 84-103 5' nucleotidase, ecto Rattus norvegicus 30-45 7462211-6 1981 The concomitant increases in lysophosphatidylcholine and decreases in phosphatidylcholine, as well as the decreases in phosphatidylethanolamine, can only be explained by the stimulation of phospholipase A2 activity in platelets by thrombin. Phosphatidylcholines 33-52 phospholipase A2 group IB Homo sapiens 189-205 7213686-2 1981 13C spin-lattice relaxation times, nuclear Overhauser effects and spin-spin relaxation times have been measured for the C-4 carbon of cholesterol in phosphatidylcholine bilayers as a function of cholesterol content and temperature. Phosphatidylcholines 149-168 complement C4A (Rodgers blood group) Homo sapiens 120-123 6263136-3 1981 Increased saturated phosphatidylcholine (SPC) synthesis without an increase in synthesis of total PC, and increased SPC/PC, was observed after exposure to Sigma prolactin. Phosphatidylcholines 42-44 prolactin Oryctolagus cuniculus 161-170 6894279-1 1981 Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7). Phosphatidylcholines 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 6260171-0 1981 An in vitro ESR study of uncatalyzed rat liver protein-catalyzed spin-labeled phosphatidylcholine exchange. Phosphatidylcholines 78-97 spindlin 1 Rattus norvegicus 65-69 6260171-1 1981 ESR spectrometry has been used to study fatty acid spin-labeled phosphatidylcholine exchange from single bilayer donor vesicles to various acceptor systems, such as intact or differently treated mitochondria, phospholipid multilamellar vesicles or single bilayer vesicles. Phosphatidylcholines 64-83 spindlin 1 Homo sapiens 51-55 6174024-4 1981 A soluble ATPase extract having low phospholipid content was found to be activated by the phospholipid extracts of Vibrio el tor, phosphatidyl ethanolamine, and also by phosphatidyl choline which is not a constituent of the membrane preparation of Vibrio el tor strains. Phosphatidylcholines 169-189 dynein axonemal heavy chain 8 Homo sapiens 10-16 6894279-1 1981 Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7). Phosphatidylcholines 45-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 7195282-0 1980 Pancreatic phospholipase A2 hydrolysis of phosphatidylcholines in various physicochemical states. Phosphatidylcholines 42-62 phospholipase A2 group IB Homo sapiens 11-27 6273927-2 1981 PC formed by transmethylation is further metabolized by phospholipase A2. Phosphatidylcholines 0-2 phospholipase A2 group IB Homo sapiens 56-72 6254970-11 1980 In the most highly purified LDL receptor preparation, which had been subjected to the sequential steps of solubilization, DEAE-cellulose chromatography, agarose gel filtration, and phosphatidylcholine/acetone precipitation, the receptor was estimated to constitute about 5% of the total protein. Phosphatidylcholines 181-200 low density lipoprotein receptor Bos taurus 28-40 7219664-4 1981 There was a tendency by the neuronal phospholipase A2 to release arachidonic acid faster than linolenic acid from both phosphatidylcholine and -ethanolamine, while arachidonic acid was removed less actively from phosphatidylethanolamine by the glial enzyme. Phosphatidylcholines 119-138 phospholipase A2 Oryctolagus cuniculus 37-53 6894548-1 1980 Incubation of rat lung microsomes with CDP[Me-14C]choline resulted in formation of radioactive lysophosphatidylcholine and phosphatidylcholine. Phosphatidylcholines 99-118 cut-like homeobox 1 Rattus norvegicus 39-42 7195282-7 1980 During an extended incubation, however, nearly all intralipid phosphatidylcholines and only half the bile phosphatidylcholines were hydrolyzed by pancreatic phospholipase A2. Phosphatidylcholines 62-82 phospholipase A2 group IB Homo sapiens 157-173 6255856-6 1980 Thrombin induced aggregation results in release of arachidonic acid primarily from phosphatidyl choline and phosphatidyl inositol. Phosphatidylcholines 83-103 coagulation factor II, thrombin Homo sapiens 0-8 7430120-9 1980 Deoxycholate treatment of the particulate fractions results in cleavage by phospholipase A2 of phosphatidylcholine and phosphatidylethanolamine but not of phosphatidylinositol. Phosphatidylcholines 95-114 phospholipase A2 Equus caballus 75-91 7430120-10 1980 The preferred substrates for platelet phospholipase A2 appear to be phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, while phosphatidylinositol seems to be degraded nearly exclusively by phospholipase C. Phosphatidylcholines 94-113 phospholipase A2 Equus caballus 38-54 7407117-5 1980 50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate. Phosphatidylcholines 10-29 rhodopsin Bos taurus 60-69 6778695-5 1980 It was shown that the apparent Km values of arylsulphatase and glycerol-3-phosphate dehydrogenase were higher in liposomes prepared with negatively charged phospholipids and lower in liposomes containing positively charged organic amines, as compared with th Km value of enzymes incorporated into liposomes prepared from phosphatidylcholine alone. Phosphatidylcholines 321-340 glycerol-3-phosphate dehydrogenase 1 Rattus norvegicus 63-97 6774752-0 1980 Reassembly of human apoproteins A-I and A-II with unilamellar phosphatidylcholine-cholesterol liposomes. Phosphatidylcholines 62-81 NLR family pyrin domain containing 3 Homo sapiens 40-44 6894263-0 1980 Correlation between serum lipoamide dehydrogenase activity and phosphatidylcholine therapy in Friedreich"s ataxia. Phosphatidylcholines 63-82 dihydrolipoamide dehydrogenase Homo sapiens 26-49 7214196-4 1980 It is concluded that LCAT possesses highly specific steric and positional requirements for its phosphatidylcholine substrates and that, like phospholipase A2, it has a significant activity with the 2-sn-phosphorylcholinedicacylglycerol. Phosphatidylcholines 95-114 lecithin-cholesterol acyltransferase Homo sapiens 21-25 7214196-4 1980 It is concluded that LCAT possesses highly specific steric and positional requirements for its phosphatidylcholine substrates and that, like phospholipase A2, it has a significant activity with the 2-sn-phosphorylcholinedicacylglycerol. Phosphatidylcholines 95-114 phospholipase A2 group IB Homo sapiens 141-157 7417445-2 1980 The permeability of phosphatidylcholine vesicles to Pr3+ is increased by several orders of magnitude over the self-diffusion rate and the kinetics indicate a transbilayer movement of inverted micelles [Pr(bile salt)4]. Phosphatidylcholines 20-39 proteinase 3 Homo sapiens 52-55 6251051-0 1980 Phosphatidylcholine vesicle reconstituted cytochrome P-450scc. Phosphatidylcholines 0-19 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 42-61 6251051-2 1980 Cytochrome P-450scc from bovine adrenal cortex mitochondria was purified and reconstituted into phosphatidylcholine vesicles which varied in both cholesterol content and in the fatty acyl composition of the phospholipid. Phosphatidylcholines 96-115 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 0-19 7407117-5 1980 50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate. Phosphatidylcholines 10-29 rhodopsin Bos taurus 88-97 7236798-5 1980 Cytochrome P-450 incorporated into the artificial membranes of phosphatidyl choline and microsomal phospholipid has almost identical secondary structure as does the soluble one. Phosphatidylcholines 63-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 7407117-5 1980 50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate. Phosphatidylcholines 113-132 rhodopsin Bos taurus 60-69 7411590-0 1980 Action of phospholipase A2 on unmodified phosphatidylcholine bilayers: organizational defects are preferred sites of action. Phosphatidylcholines 41-60 phospholipase A2 group IB Homo sapiens 10-26 6783529-7 1980 Both the inner and outer leaflets of the erythrocyte membrane were accessible to this rickettsial phospholipase A activity since both phosphatidylcholine and phosphatidylethanolamine were substrates in human erythrocytes. Phosphatidylcholines 134-153 phospholipase A and acyltransferase 1 Homo sapiens 98-113 6771275-7 1980 In addition, the turnover of phosphatidylcholine is more rapid in the cho1 mutant. Phosphatidylcholines 29-48 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 70-74 7407051-2 1980 The linear peptide hormones angiotensin II and [Asn1, Val5]angiotensin II are found to mediate the transport of Mn(II) ions across phosphatidylcholine bilayers. Phosphatidylcholines 131-150 angiotensinogen Homo sapiens 28-42 7407051-2 1980 The linear peptide hormones angiotensin II and [Asn1, Val5]angiotensin II are found to mediate the transport of Mn(II) ions across phosphatidylcholine bilayers. Phosphatidylcholines 131-150 angiotensinogen Homo sapiens 59-73 7411590-1 1980 The hydrolytic action of the bee venom phospholipase A2 on phosphatidylcholine bilayers is studied under a variety of conditions that introduce alterations in the packing, such as those induced by sonication, gel to liquid crystalline phase transition, and osmotic shock. Phosphatidylcholines 59-78 phospholipase A2 group IB Homo sapiens 39-55 7364757-5 1980 On the other hand, SPF was shown to bind tightly to vesicles of anionic phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, and phosphatidic acid) but not to vesicles of phosphatidylcholine or phosphatidylethanolamine. Phosphatidylcholines 197-216 SEC14 like lipid binding 2 Homo sapiens 19-22 6158688-0 1980 Transmembrane orientation of lipophilin in phosphatidylcholine vesicles. Phosphatidylcholines 43-62 proteolipid protein 1 Homo sapiens 29-39 6158688-1 1980 Lipophilin, a hydrophobic myelin protein, was incorporated into phosphatidylcholine vesicles by dialysis from 2-chloroethanol which has been shown to produce single-layered lipid-protein vesicles. Phosphatidylcholines 64-83 proteolipid protein 1 Homo sapiens 0-10 7397160-1 1980 The kinetics of Ca2+-induced fusion of phosphatidylcholine-phosphatidic acid vesicles has been studied using the dependence of proton nuclear magnetic resonance linewidths on vesicle size. Phosphatidylcholines 39-58 carbonic anhydrase 2 Homo sapiens 16-19 7190145-0 1980 C-Reactive protein induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine. Phosphatidylcholines 102-121 C-reactive protein Homo sapiens 0-18 7190145-1 1980 CRP-induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine was studied by a newly devised quantitative method. Phosphatidylcholines 87-106 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphatidylcholines 69-88 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphatidylcholines 207-226 C-reactive protein Homo sapiens 0-3 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphatidylcholines 9-28 C-reactive protein Homo sapiens 134-137 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphatidylcholines 303-322 C-reactive protein Homo sapiens 134-137 7378381-0 1980 Mechanism of exchange of cytochrome b5 between phosphatidylcholine vesicles. Phosphatidylcholines 47-66 cytochrome b5 type A Homo sapiens 25-38 7370284-14 1980 The binding of colipase to Intralipid, an emulsion of a long-chain triacylglycerol stabilized with phosphatidylcholine and glycerol, was more complex with indications of several different binding sites with different affinity. Phosphatidylcholines 99-118 colipase Homo sapiens 15-23 6245576-2 1980 Preliminary results suggest that phosphatidylcholine synthesis via the phosphatidic acid phosphohydrolase pathway in addition to phosphatidylglycerol may be stimulated by the presence of prolactin. Phosphatidylcholines 33-52 prolactin Homo sapiens 187-196 6244061-3 1980 Axonal transport of 1,2-diacyl-glycerol:CDP-choline choline phosphotransferase (EC 2.7.8.2), required for de novo phosphatidylcholine synthesis, was not apparent in these studies. Phosphatidylcholines 114-133 cut-like homeobox 1 Rattus norvegicus 40-43 6243290-1 1980 Poliovirus increases phosphatidylcholine biosynthesis in HeLa cells by stimulation of the reaction catalyzed by CTP:phosphocholine cytidylyltransferase (Vance, D.E., Trip, E.M., and Paddon, H.B. Phosphatidylcholines 21-40 solute carrier family 25 member 1 Homo sapiens 112-115 7354136-3 1980 Lysine and aspartic acid appeared to modify the cholinephosphotransferase reaction in which cytidine 5"-diphosphocholine (CDP-choline) and 1,2-diacylglycerol react to form phosphatidylcholine, the major phospholipid of renal membranes. Phosphatidylcholines 172-191 cut-like homeobox 1 Rattus norvegicus 122-125 6243483-16 1980 The differences in the results obtained with the various phosphatidylcholines above their transition temperature suggest that the solubility of rhodopsin in bilayers depends not only on the fluidity of the lipids, but also, to some extent, on the phospholipid chain length. Phosphatidylcholines 57-77 rhodopsin Bos taurus 144-153 6243999-3 1980 Spin labels derived from five carboxylic acids of different lengths were synthesized and incorporated in varying amounts into multilamellar and unilamellar vesicles made up of four different phosphatidylcholines. Phosphatidylcholines 191-211 spindlin 1 Homo sapiens 0-4 6243290-14 1980 Moreover, it appears that the concentration of CTP in the cytoplasm can determine the rate of phosphatidylcholine biosynthesis in HeLa cells. Phosphatidylcholines 94-113 solute carrier family 25 member 1 Homo sapiens 47-50 7370002-8 1980 Liver mitochondria isolated from normal animals incubated in vitro with CDP-choline, in the presence of different concentrations of L-thyroxine, showed also a marked decrease in the incorporation of label into phosphatidylcholine, whereas no significant changes were found in the total homogenate and in the microsomal fraction compared with control experiments. Phosphatidylcholines 210-229 cut-like homeobox 1 Rattus norvegicus 72-75 6768948-0 1980 Interaction of human plasma high density lipoprotein HDL2 with synthetic saturated phosphatidylcholines. Phosphatidylcholines 83-103 junctophilin 3 Homo sapiens 53-57 6768948-4 1980 Redistributed apoA-I occurred as lipid-free apoA-I and/or as complexes of apoA-I and/or as compelxes of apoA-I with phosphatidylcholine. Phosphatidylcholines 116-135 apolipoprotein A1 Homo sapiens 14-20 6156917-3 1980 A simultaneous striking increase in prostaglandin D2 synthesis by the A23187-treated mast cells suggests that the degradation of phosphatidylcholine is associated with the activation of phospholipase A2. Phosphatidylcholines 129-148 phospholipase A2 group IB Rattus norvegicus 186-202 6775511-3 1980 Additional components are NADPH-cytochrome P-450 reductase, which binds to the cytochrome to form a tight 1:1 complex, phosphatidylcholine, and cytochrome b5, the role of which is still not clear. Phosphatidylcholines 119-138 cytochrome p450 oxidoreductase Homo sapiens 26-58 7358621-0 1980 Topological studies of the membrane-binding segment of cytochrome b5 embedded in phosphatidylcholine vesicles. Phosphatidylcholines 81-100 cytochrome b5 type A Homo sapiens 55-68 231173-0 1979 Ethanolamine kinase activity and compositions of diacylglycerols, phosphatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats. Phosphatidylcholines 66-86 choline kinase beta Rattus norvegicus 0-19 7358621-1 1980 Carboxypeptidase Y (CPY) digestion of cytochrome b5 incorporated into single-walled liposomes of egg phosphatidylcholine (PC) resulted in the release of 25 amino acid residues form each molecule of the cytochrome and concomitant detachment of the cytochrome from the vesicles. Phosphatidylcholines 101-120 cytochrome b5 type A Homo sapiens 38-51 7358621-1 1980 Carboxypeptidase Y (CPY) digestion of cytochrome b5 incorporated into single-walled liposomes of egg phosphatidylcholine (PC) resulted in the release of 25 amino acid residues form each molecule of the cytochrome and concomitant detachment of the cytochrome from the vesicles. Phosphatidylcholines 122-124 cytochrome b5 type A Homo sapiens 38-51 7243826-1 1980 Enzymatic methylation of phosphotidylethanolamine (PE) to form phosphatidylcholine (PC) is associated with translocation of the lipid from the inner cell membrane (PE) to the outer membrane (PC), a concomitant decrease in membrane viscosity, and in some cases, activation of phospholipase A and release of arachidonic acid. Phosphatidylcholines 63-82 phospholipase A and acyltransferase 1 Rattus norvegicus 275-290 7243826-1 1980 Enzymatic methylation of phosphotidylethanolamine (PE) to form phosphatidylcholine (PC) is associated with translocation of the lipid from the inner cell membrane (PE) to the outer membrane (PC), a concomitant decrease in membrane viscosity, and in some cases, activation of phospholipase A and release of arachidonic acid. Phosphatidylcholines 84-86 phospholipase A and acyltransferase 1 Rattus norvegicus 275-290 500697-2 1979 Cytochrome P-450scc can be reconstituted into a phospholipid bilayer in the absence of added detergent by incubation of purified hemoprotein with preformed phosphatidylcholine vesicles. Phosphatidylcholines 156-175 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 0-19 293667-0 1979 Lateral mobility of an amphipathic apolipoprotein, ApoC-III, bound to phosphatidylcholine bilayers with and without cholesterol. Phosphatidylcholines 70-89 apolipoprotein C3 Homo sapiens 51-59 43142-6 1979 Furthermore hydrolysis of phosphatidylcholine by the skin phospholipase A was also enhanced by low concentrations of prostaglandin E2 and prostaglandin F2 alpha. Phosphatidylcholines 26-45 phospholipase A and acyltransferase 1 Homo sapiens 58-73 387773-8 1979 We conclude that bradykinin, thrombin, and serum activate phospholipases that specifically hydrolyze arachidonyl and eicosatrienoyl phosphatidylinositol and phosphatidylcholine, whereas A23187 is less specific activator of phospholipases. Phosphatidylcholines 157-176 coagulation factor II Mus musculus 29-37 293667-3 1979 In egg phosphatidylcholine bilayers, D is about 3 x 10(-8) cm(2) sec(-1) at 20 degrees C and the Arrhenius activation energy for diffusion is 8.1 kcal mol(-1) between 15 and 35 degrees C in this system. Phosphatidylcholines 7-26 secretory blood group 1, pseudogene Homo sapiens 65-71 293667-4 1979 In bilayers prepared from an equimolar mixture of egg phosphatidylcholine and cholesterol D at 20 degrees C is about 1.4 x 10(-9) cm(2) sec(-1) and the Arrhenius activation energy for the diffusion of the protein in this system between 15 and 35 degrees C is 15.1 kcal mol(-1). Phosphatidylcholines 54-73 secretory blood group 1, pseudogene Homo sapiens 136-142 293667-1 1979 The technique of fluorescence recovery after photobleaching was used to investigate the lateral mobility of a fluorescein-labeled amphipathic apolipoprotein, ApoC-III, bound to multibilayers prepared from dipalmitoyl phosphatidylcholine, egg phosphatidylcholine, and a 1:1 (molar ratio) mixture of egg phosphatidylcholine and cholesterol. Phosphatidylcholines 217-236 apolipoprotein C3 Homo sapiens 158-166 293667-1 1979 The technique of fluorescence recovery after photobleaching was used to investigate the lateral mobility of a fluorescein-labeled amphipathic apolipoprotein, ApoC-III, bound to multibilayers prepared from dipalmitoyl phosphatidylcholine, egg phosphatidylcholine, and a 1:1 (molar ratio) mixture of egg phosphatidylcholine and cholesterol. Phosphatidylcholines 242-261 apolipoprotein C3 Homo sapiens 158-166 471064-0 1979 Interaction of C-reactive protein with artificial phosphatidylcholine bilayers. Phosphatidylcholines 50-69 C-reactive protein Homo sapiens 15-33 391228-0 1979 Asymmetry requirement for Ca2+ induced fusion of phosphatidylcholine-phosphatidic acid vesicles. Phosphatidylcholines 49-68 carbonic anhydrase 2 Homo sapiens 26-29 471064-3 1979 CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM). Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 0-3 476097-2 1979 The C15-, C17- and C19-diacyl species show gel to liquid-crystalline transitions and pretransitions like those of the even-chain phosphatidylcholines. Phosphatidylcholines 129-149 placenta associated 8 Homo sapiens 4-7 573139-1 1979 The addition of Ca2+ to small unilamellar vesicles of an equimolar mixture of egg phosphatidylcholine and cardiolipin induces fusion of these vesicles in association with the appearance of lipidic particles on the fusion sites. Phosphatidylcholines 82-101 carbonic anhydrase 2 Homo sapiens 16-19 227688-5 1979 The results are explained by assuming that the transport unit and the catalytic moiety of the glucose-6-phosphatase system have different lipid requirements, the activity of the former protein depending mainly on phosphatidylethanolamine and phosphatidylserine and that of the catalytic protein depending on phosphatidylcholine. Phosphatidylcholines 308-327 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 94-115 227688-7 1979 THis suggests that the diminished activity of glucose-6-phosphatase in hepatomas may be partly due to a low level of phosphatidylcholine. Phosphatidylcholines 117-136 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 46-67 226973-1 1979 Human beta-endorphin adopts a partial helical conformation in aqueous solutions of cerebroside sulfate, ganglioside GM1, phosphatidylserine, and phosphatidic acid, but not of cerebroside and phosphatidylcholine, as evidenced by circular dichroic spectra. Phosphatidylcholines 191-210 proopiomelanocortin Homo sapiens 6-20 476097-2 1979 The C15-, C17- and C19-diacyl species show gel to liquid-crystalline transitions and pretransitions like those of the even-chain phosphatidylcholines. Phosphatidylcholines 129-149 cytokine like 1 Homo sapiens 10-13 582621-2 1979 When 14C-glucose was used as substrate, incorporation into both phosphatidylcholine and saturated phosphatidylcholine was reduced by insulin. Phosphatidylcholines 64-83 insulin Oryctolagus cuniculus 133-140 582173-1 1979 The activity of phospholipase A2 from cobra venom toward phospholipid in single-walled, sonicated vesicles was analyzed, particularly with respect to its activity toward the saturated phosphatidylcholines in the gel and liquid crystalline states. Phosphatidylcholines 184-204 phospholipase A2 group IB Homo sapiens 16-32 447630-0 1979 Mechanism of cytochrome b5 binding to phosphatidylcholine vesicles. Phosphatidylcholines 38-57 cytochrome b5 type A Homo sapiens 13-26 454594-6 1979 From the initial velocity rate, the time required for the phosphatidylcholine pool to double was about 12 h. Agarose-linked phospholipase A2 was used to measure the relative composition of choline- and dimethylethanolamine-phosphoglycerides in the outer surface of vesicles prepared from cells with different degrees of polar head group substitution. Phosphatidylcholines 58-77 phospholipase A2 group IB Homo sapiens 124-140 223955-1 1979 Lipoprotein particles reconstituted from the apolipoprotein AII (apo AII) component of human serum high density lipoprotein, phosphatidylcholine and lysophosphatidylcholine were covalently linked to the imidoester groups of a polystyrene residue. Phosphatidylcholines 125-144 apolipoprotein A2 Homo sapiens 45-63 223955-1 1979 Lipoprotein particles reconstituted from the apolipoprotein AII (apo AII) component of human serum high density lipoprotein, phosphatidylcholine and lysophosphatidylcholine were covalently linked to the imidoester groups of a polystyrene residue. Phosphatidylcholines 125-144 apolipoprotein A2 Homo sapiens 65-72 223956-1 1979 Apolipoprotein AII isolated from human serum high density lipoproteins was recombined with phosphatidylcholine to yield homogeneous particles of 80-120 A diameter. Phosphatidylcholines 91-110 apolipoprotein A2 Homo sapiens 0-18 459721-4 1979 Three times more elaidic than oleic acid (OI) accumulated in the 1-acyl position of phosphatidylcholine, as determined by hydrolysis with phospholipase A2. Phosphatidylcholines 84-103 phospholipase A2 group IB Homo sapiens 138-154 456381-4 1979 The transition temperature from gel-crystalline to liquid-crystalline phase in 24 degrees C for the dimyristoyl-phosphatidylcholine vesicles and is shifted to around 30 degrees C in the complexes between phosphatidylcholine and apoA-I, apoA-II, apoC-I, apoC-III proteins while the cooperativity of the transition is decreased. Phosphatidylcholines 112-131 apolipoprotein A1 Homo sapiens 228-234 456381-5 1979 At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine . Phosphatidylcholines 97-116 apolipoprotein A1 Homo sapiens 122-128 456381-5 1979 At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine . Phosphatidylcholines 97-116 apolipoprotein A2 Homo sapiens 130-137 456381-5 1979 At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine . Phosphatidylcholines 97-116 apolipoprotein C1 Homo sapiens 142-148 35234-0 1979 Phospholipase A2 in rat-lung microsomes: substrate specificity towards endogenous phosphatidylcholines. Phosphatidylcholines 82-102 phospholipase A2 group IB Rattus norvegicus 0-16 465128-10 1979 Compared with NaOH-purified elastin, the other elastin samples were characterized by an increased phosphatidyl--choline content, while they all contained an almost equal amount of phosphatidylethanolamine. Phosphatidylcholines 98-119 elastin Homo sapiens 47-54 221897-2 1979 When EL4 membranes are incubated with sonicated lipid vesicles containing spin-labeled phosphatidylcholine and then purified, they exhibit paramagnetic resonance spectra characteristic of spin labels dilutely dispersed in the lipid bilayer. Phosphatidylcholines 87-106 epilepsy 4 Mus musculus 5-8 113393-7 1979 The partially purified cytochrome P-450 was active in fatty acid hydroxylation in combination with intestinal NADPH-cytochrome c reductase and phosphatidylcholine. Phosphatidylcholines 143-162 cytochrome P-450 Oryctolagus cuniculus 23-39 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylcholines 256-276 tachykinin precursor 1 Homo sapiens 60-62 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylcholines 256-276 tachykinin precursor 1 Homo sapiens 105-107 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylcholines 256-276 tachykinin precursor 1 Homo sapiens 105-107 420827-3 1979 One enzyme with phospholipase A2 specificity was found to be responsible for both phosphatidyl-ethanolamine and phosphatidylcholine degradation. Phosphatidylcholines 112-131 phospholipase A2 Ovis aries 16-32 284415-2 1979 Towards this end, we have constructed unilamellar phosphatidylcholine liposomes containing H-2 and Ia antigens. Phosphatidylcholines 50-69 relaxin 2 Homo sapiens 91-101 42250-3 1979 Phosphatidylcholine is required in the reconstituted enzyme system for rapid electron transfer from NADPH to P-450 LM, catalyzed by NADPH-cytochrome P-450 reductase, as well as for maximal hydroxylation activity with either molecular oxygen or a peroxy compound serving as oxygen donor to the substrate. Phosphatidylcholines 0-19 cytochrome p450 oxidoreductase Homo sapiens 132-164 103585-0 1979 Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. Phosphatidylcholines 93-112 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 20-52 103585-0 1979 Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. Phosphatidylcholines 93-112 cytochrome P-450 Oryctolagus cuniculus 26-42 103585-6 1979 The rate constant of the slow phase as well as the fraction of cytochrome P-450 reducible in the slow phase, on the other hand, remains essentially constant even upon alteration in the ratio of the reductase to the cytochrome or in that of the two proteins to phosphatidylcholine. Phosphatidylcholines 260-279 cytochrome P-450 Oryctolagus cuniculus 63-79 758952-0 1979 Inhibition of the binding of cytochrome b5 to phosphatidylcholine vesicles by cholesterol. Phosphatidylcholines 46-65 cytochrome b5 type A Homo sapiens 29-42 758952-1 1979 The binding of cytochrome b5 to single-walled liposomes of egg phosphatidylcholine was inhibited by the presence of cholesterol in the lipid bilayer under conditions where a limited amount of liposomes was incubated with the cytochrome. Phosphatidylcholines 63-82 cytochrome b5 type A Homo sapiens 15-28 216396-1 1978 The hydrolytic activity of a lipoprotein lipase from bovine milk against triacylglycerol and phosphatidylcholine of rat plasma very low density lipoprotein was determined and compared to that against phosphatidylcholine of high density lipoprotein. Phosphatidylcholines 93-112 lipoprotein lipase Bos taurus 29-47 583227-7 1979 It was concluded that the observed LPL and TGLH activation may account for the beneficial therapeutic effects of highly unsaturated phosphatidylcholine (EPL) in human hyperglyceridemias. Phosphatidylcholines 132-151 lipoprotein lipase Homo sapiens 35-38 486580-0 1979 [Influence of phosphatidylcholine/cholesterol molar ratios in liposomes on cholesterol reactivity with cholesterol:oxygen oxidoreductase]. Phosphatidylcholines 14-33 thioredoxin reductase 1 Homo sapiens 122-137 739004-1 1978 Rabbit cytochrome b5 was incorporated into single-walled phosphatidylcholine liposomes, and the cytochrome b5-liposome complex thus formed was digested with trypsin. Phosphatidylcholines 57-76 cytochrome b5 Oryctolagus cuniculus 7-20 32674-2 1978 Platelets, as in platelet rich plasma when labelled with arachidonic acid, washed and treated with thrombin, released radioactivity mainly from phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 144-163 coagulation factor II, thrombin Homo sapiens 99-107 27520426-0 1978 Rapid enzyme-induced hydrolysis of microgram amounts of phosphatidylcholine on phospholipase A2/celite columns. Phosphatidylcholines 56-75 phospholipase A2 group IB Homo sapiens 79-95 307491-15 1978 In infants with RDS, PC is low and PG absent. Phosphatidylcholines 21-23 peripherin 2 Homo sapiens 16-19 214141-2 1978 Thrombin-induced release of arachidonic acid from human platelet phosphatidylcholine is found to be more than 90% impaired by incubation of platelets with 1 mM dibutyryl cyclic adenosine monophosphate (Bt2 cyclic AMP) or with 0.6 mM 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate (TMB-8), an intracellular calcium antagonist. Phosphatidylcholines 65-84 coagulation factor II, thrombin Homo sapiens 0-8 689034-2 1978 1-O-Alkyl-2-acyl-3-acetyl-glycerols and 1,2-diacyl-3-acetylglycerols were prepared from the ethanolamine and choline phosphoglycerides and fractionated by AgNO3-impregnated thin-layer chromatography into seven molecular species. Phosphatidylcholines 109-134 O-acyltransferase like Mus musculus 12-18 677904-0 1978 Effect of the state of phosphatidylcholine on the rate of its hydrolysis by phospholipase A2 (bee venom). Phosphatidylcholines 23-42 phospholipase A2 group IB Homo sapiens 76-92 658423-0 1978 Reconstitution of acetylcholinesterase activity from electroplax membrane fragments into phosphatidylcholine vesicles. Phosphatidylcholines 89-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 207309-0 1978 Kinetics of lipid--protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines. Phosphatidylcholines 124-144 apolipoprotein A1 Homo sapiens 56-74 638181-8 1978 Colipase alone exhibited strong binding to phosphatidylcholine and fatty acid mixed bile salt micelles when applied together in a sample on columns eluted with pure bile salt micelles, lipase did not. Phosphatidylcholines 43-62 colipase Homo sapiens 0-8 204348-1 1978 The nature of the interaction between Sendai virus and Sil mutant cells was examined by measuring a change in ESR spectrum of spin-labeled phosphatidylcholine molecules on the viral envelope. Phosphatidylcholines 139-158 STIL centriolar assembly protein Homo sapiens 55-58 147706-13 1978 Hydrolysis of 95% of the phosphatidylcholine and 60--70% of the spingomyelin and phosphatidylethanolamine by another phospholipase C (Clostridium welchii) lowers the (Na+ + K+)-ATPase activity by about 20%. Phosphatidylcholines 25-44 LOC100009319 Oryctolagus cuniculus 117-132 565217-2 1978 We examined the action of porcine pancreatic and bee-venom phospholipase A2 towards bilayers of phosphatidylcholine as a function of several physical characteristics of the lipid-water interface. Phosphatidylcholines 96-115 phospholipase A2 group IB Homo sapiens 59-75 565217-17 1978 Vesicles composed of egg phosphatidylcholine can be degraded by pancreatic phospholipase A2 at 37 degrees C, provided that the substrate bilayer is strongly curved. Phosphatidylcholines 25-44 phospholipase A2 group IB Homo sapiens 75-91 655003-1 1978 Thrombin, within seconds after its addition, stimulated the release of 1-14C-20:4n-6 from the platelet phospholipids, phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 118-137 coagulation factor II, thrombin Homo sapiens 0-8 629969-10 1978 Treatment of co-sonicated vesicles of phosphatidylcholine and lysophosphatidylcholine containing glycophorin with the enzyme lysophospholipase results in a complete degradation of the lyso-compound. Phosphatidylcholines 38-57 phospholipase B1 Homo sapiens 125-142 656483-3 1978 When such microsomes were incubated with phosphatidylcholine in the presence of lipid exchange proteins the lysophosphatidylcholine was partly replaced by phosphatidylcholine and the inactive cytochrome P-450 was reactivated. Phosphatidylcholines 41-60 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 656483-3 1978 When such microsomes were incubated with phosphatidylcholine in the presence of lipid exchange proteins the lysophosphatidylcholine was partly replaced by phosphatidylcholine and the inactive cytochrome P-450 was reactivated. Phosphatidylcholines 112-131 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 208359-4 1978 Incubation of microsomes with labeled alkylacylglycerols and CDP-choline, in the initial absence of CDP-ethanolamine, produced labeled ethanolamine glycerophospholipids as well as labeled choline glycerophospholipids. Phosphatidylcholines 188-216 cut-like homeobox 1 Rattus norvegicus 61-64 200275-0 1977 Hydrolysis of phosphatidylcholine by phospholipase A2 does not cause dissociation of apolipoprotein C from rat plasma very low density lipoprotein. Phosphatidylcholines 14-33 phospholipase A2 group IB Rattus norvegicus 37-53 623825-2 1978 The resistance of BLM formed from phosphatidylcholine, tiophosphatidylcholine, threealkylphosphate and threealkyltiophosphate was 10(7)--10(8) Ohm.cm2. Phosphatidylcholines 34-53 BLM RecQ like helicase Homo sapiens 18-21 271994-9 1977 We conclude that (i) CRP can sensitize appropriate liposomes for complement-dependent damage via the primary complement pathway starting at the level of C1q; (ii) of those studied, liposomes that are most susceptible to membrane damage contain phosphatidylcholine, have a positive charge, and contain a ceramide glycolipid; and (iii) such liposomes also are sensitive, although to a much lesser degree, to complement-dependent lysis initiated in the absence of CRP and involving consumption of terminal in excess of early acting complement components. Phosphatidylcholines 244-263 C-reactive protein Homo sapiens 21-24 717398-7 1978 The uptake of free 14 C-arachidonic acid by the platelets was greatly diminished, as was its thrombin-induced liberation from phosphatidyl-choline and phosphatidyl inositol. Phosphatidylcholines 126-146 coagulation factor II, thrombin Homo sapiens 93-101 746344-0 1978 Phosphatidylcholine substrate specificity of lecithin:cholesterol acyltransferase. Phosphatidylcholines 0-19 lecithin-cholesterol acyltransferase Homo sapiens 45-81 746344-4 1978 It was found that the fatty acid in the 1-position of phosphatidylcholine significantly influences cholesteryl ester formation, both by its direct involvement in the LCAT reaction and its contribution to the physico-chemical properties of phosphatidylcholine. Phosphatidylcholines 54-73 lecithin-cholesterol acyltransferase Homo sapiens 166-170 271947-0 1977 Light-regulated permeability of rhodopsin:egg phosphatidylcholine recombinant membranes. Phosphatidylcholines 46-65 rhodopsin Homo sapiens 32-41 271947-1 1977 Purified rhodopsin was incorporated into phospholipid bilayers of egg phosphatidylcholine to give recombinant membrane vesicles, which were examined by proton and phosphorus nuclear magnetic resonance spectroscopy. Phosphatidylcholines 70-89 rhodopsin Homo sapiens 9-18 199582-1 1977 Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate. Phosphatidylcholines 119-138 lecithin-cholesterol acyltransferase Homo sapiens 0-37 20951-1 1977 Myelin basic protein associates with bilayer vesicles of pure egg phosphatidylcholine, L-alpha-dimyristoyl phosphatidylcholine and DL-alpha-dipalmitoyl phosphatidylcholine. Phosphatidylcholines 66-85 myelin basic protein Homo sapiens 0-20 199582-1 1977 Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate. Phosphatidylcholines 119-138 lecithin-cholesterol acyltransferase Homo sapiens 39-43 199582-1 1977 Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate. Phosphatidylcholines 119-138 apolipoprotein A1 Homo sapiens 74-92 199582-1 1977 Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate. Phosphatidylcholines 119-138 apolipoprotein A1 Homo sapiens 94-100 199582-4 1977 On the other hand, all of these phosphatidylcholines acted as substrates of LCAT when they were incorporated into HDL coupled to Sepharose. Phosphatidylcholines 32-52 lecithin-cholesterol acyltransferase Homo sapiens 76-80 142518-5 1977 Insulin treatment of normal animals 30 or 15 min prior to perfusion resulted in an approximate doubling of the incorporation of glucose into the phosphatidylcholine and phosphatidylglycerol isolated from the surfactant and residual fractions of the lung. Phosphatidylcholines 145-164 insulin Homo sapiens 0-7 197573-2 1977 The existence of marked differences in the degradation rate for each phospholipid suggests a relationship between the alteration of phosphatidylcholine containing one saturated and one unsaturated fatty acid and the decrease in activity of glucose-6-phosphatase; the inactivation of this enzyme was unrelated to the alteration of other phospholipids. Phosphatidylcholines 132-151 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 240-261 195609-0 1977 NMR and ESR studies of the interactions of cytochrome c with mixed cardiolipin-phosphatidylcholine vesicles. Phosphatidylcholines 79-98 cytochrome c, somatic Homo sapiens 43-55 196853-2 1977 The ethanols were administered to female bile fistula rats for 10 h. The hydrogen at C-2 in the glycerol moiety of newly formed phosphatidylcholine molecules in bile, liver and plasma was derived to 22-25% from the 1-pro-R position and to 5-6% from the 1-pro-S position in the ethanol. Phosphatidylcholines 128-147 complement C2 Rattus norvegicus 85-88 873919-1 1977 Detergent-extracted cytochrome b5, which binds readily to phosphatidylcholine vesicles, has been shown to exchange between vesicles by the following experiments. Phosphatidylcholines 58-77 cytochrome b5 type A Homo sapiens 20-33 874074-3 1977 Human platelets have a mechanism for incorporating arachidonic acid from plasma into their phospholipids and, in response to thrombin, they reveal mechanisms for hydrolyzing this arachidonic acid from platelet phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 210-229 coagulation factor II, thrombin Homo sapiens 125-133 861238-1 1977 The relationship between lipoprotein lipase activity and uptake of triacylglycerol, cholesterol and phosphatidylcholine from chylomicrons was studied in mammary gland and adipose tissue of rats lactating 6--7 days. Phosphatidylcholines 100-119 lipoprotein lipase Rattus norvegicus 25-43 406914-3 1977 Bovine serum albumin increased the hemolysis of human erythrocytes induced by dilauroylglycerophosphocholine or didecanoylglycerophosphocholine: it shortened the lag time of lysis and reduced the amount of phosphatidylcholine required for lysis. Phosphatidylcholines 206-225 albumin Homo sapiens 13-20 196860-1 1977 The action of lecithin:cholesterol acyltransferase (LCAT) was studied on an abnormal lipoprotein (LP-X) rich in phosphatidylcholine and cholesterol from the plasma of patients with obstructive liver disease. Phosphatidylcholines 112-131 lecithin-cholesterol acyltransferase Homo sapiens 14-50 196860-1 1977 The action of lecithin:cholesterol acyltransferase (LCAT) was studied on an abnormal lipoprotein (LP-X) rich in phosphatidylcholine and cholesterol from the plasma of patients with obstructive liver disease. Phosphatidylcholines 112-131 lecithin-cholesterol acyltransferase Homo sapiens 52-56 598786-1 1977 The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens. Phosphatidylcholines 74-93 arginine vasopressin Rattus norvegicus 97-100 598786-1 1977 The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens. Phosphatidylcholines 74-93 arginine vasopressin Rattus norvegicus 228-231 140874-1 1977 The Ca2+-ATPase of sarcoplasmic reticulum can be reversibly delipidated by precipitation with polyethyleneglycol in the presence of deoxycholate and glycerol to as low as 4 mol of phospholipid/mol of enzyme polypeptide and can then be reactivated to 90% of its original ATPase activity by the addition of phosphatidylcholine. Phosphatidylcholines 305-324 dynein axonemal heavy chain 8 Homo sapiens 9-15 837884-1 1977 The addition of prolactin to the 150,000 x g sedimented fraction of mammary gland homogenates increased by about two-fold the rate of [3H]-arachidonic acid released from phosphatidyl choline. Phosphatidylcholines 170-190 prolactin Homo sapiens 16-25 557336-3 1977 Changes in the absorption spectra of glycerol-water mixtures of rhodopsin-egg phosphatidylcholine and rhodopsin-asolectin recombinants were monitored after the sample was cooled to -196 degrees C, presented with light of wavelength greater than 440 nm, and then warmed gradually to room temperature. Phosphatidylcholines 78-97 rhodopsin Homo sapiens 64-73 856267-5 1977 Removal of cholesterol from resealed ghosts by incubation with egg phosphatidylcholine liposomes resulted in the binding of cytochrome b5 to the outer surface of the treated ghosts. Phosphatidylcholines 67-86 cytochrome b5 type A Homo sapiens 124-137 837884-3 1977 The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland. Phosphatidylcholines 51-71 prolactin Homo sapiens 86-95 837884-3 1977 The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland. Phosphatidylcholines 51-71 phospholipase A and acyltransferase 1 Homo sapiens 107-122 837884-3 1977 The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland. Phosphatidylcholines 51-71 prolactin Homo sapiens 178-187 849477-0 1977 Leakage of sucrose from phosphatidylcholine liposomes induced by interaction with serum albumin. Phosphatidylcholines 24-43 albumin Rattus norvegicus 82-95 849477-1 1977 Liposomes composed of rat-liver phosphatidylcholine rapidly lose entrapped sucrose when incubated in presence of blood or of solutions of bovine serum albumin. Phosphatidylcholines 32-51 albumin Rattus norvegicus 145-158 849774-0 1977 [Action of chlorphentermine on the hydrolysis of phosphatidyl choline by phospholipase A2 (author"s transl)]. Phosphatidylcholines 49-69 phospholipase A2 group IB Homo sapiens 73-89 190241-6 1977 Phospholipase A treatment of intact microsomes in the presence of albumin hydrolyzed all of the phosphatidylethanolamine, phosphatidylserine, and 55% of the phosphatidylcholine. Phosphatidylcholines 157-176 phospholipase A and acyltransferase 1 Homo sapiens 0-15 952985-12 1976 As in seminal plasma phospholipase A2, the activity in crude Naja naja venom towards sonicated radioactively labelled phosphatidylcholine was stimulated at low and inhibited at high concentrations of dibucaine and chloropromazine, for example. Phosphatidylcholines 118-137 phospholipase A2 group IB Homo sapiens 21-37 188457-2 1976 2H and 31P spin-lattice relaxation times (T1) were studied for inverted egg phosphatidylcholine micelles in CCl4 as functions of 2H2O concentration. Phosphatidylcholines 76-95 C-C motif chemokine ligand 4 Homo sapiens 108-112 1010852-0 1976 Release of fatty acids from phosphatidylcholine by lecithin-cholesterol acyltransferase. Phosphatidylcholines 28-47 lecithin-cholesterol acyltransferase Homo sapiens 51-87 1010852-1 1976 Partially purified lecithin-cholesterol acyltransferase [EC 2.3.1.43] from human plasma released fatty acids from phosphatidylcholine. Phosphatidylcholines 114-133 lecithin-cholesterol acyltransferase Homo sapiens 19-55 992582-5 1976 Analyses of the liver phosphatidylcholine by specific enzymatic hydrolysis with phospholipase A2, 6 h after the application, showed that in the isolated PC 9 times more labelled fatty acids from the original 1-position were present than from the corresponding 2-position. Phosphatidylcholines 22-41 proprotein convertase subtilisin/kexin type 9 Rattus norvegicus 153-157 191277-1 1976 In sympathetic ganglia stimulated in the presence of HC-3, the reduction in number of synaptic vesicles was observed to be accompanied by a significant decrease of the ganglionic phosphatidylcholine content. Phosphatidylcholines 179-198 CYCS pseudogene 24 Homo sapiens 53-57 12743-2 1976 The adsorption of [14C]carboxymethylated glyceraldehyde 3-phosphate dehydrogenase to negatively charged liposomes of phsphatidic acid/phosphatidylcholine (3:7, w/w) was investigated. Phosphatidylcholines 134-153 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 41-81 187172-4 1976 Analysis of the myelin pellet obtained after centrifugation of the myelin sample incubated with snake venom or phospholipase A alone showed conversion of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine into their corresponding lyso compounds. Phosphatidylcholines 154-173 phospholipase A and acyltransferase 1 Homo sapiens 111-126 949475-6 1976 Bilayers prepared from extracted disk lipids had a microviscosity which was about one-fourth that of the intact disk membrane, demonstrating that rhodopsin hinders the mobility of the hydrocarbon chains of the disk phospholipids or egg phosphatidylcholine had identical microviscosities despite the much higher degree of unsaturation of the disk phospholipids. Phosphatidylcholines 236-255 rhodopsin Bos taurus 146-155 952908-8 1976 Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen. Phosphatidylcholines 92-111 fibrinogen beta chain Homo sapiens 6-16 952908-8 1976 Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen. Phosphatidylcholines 179-198 fibrinogen beta chain Homo sapiens 6-16 188485-2 1976 We have studied the interaction of an apolipoprotein from human very low density lipoproteins (apoC-III) with egg yolk phosphatidylcholine in the form of single- and multi-bilayer vesicles. Phosphatidylcholines 119-138 apolipoprotein C3 Homo sapiens 95-103 1276220-4 1976 Pancreatic phospholipase A2, an enzyme unable to hydrolyse the phospholipids of intact erythrocytes, partially degrades phosphatidylcholine and phosphatidylethanolamine of erythrocytes pretreated with hexanol or SH reagents. Phosphatidylcholines 120-139 phospholipase A2 group IB Homo sapiens 11-27 178361-5 1976 These labeled phosphatidylcholine molecules were incorporated into the membrane by incubation of the red cells at 22 degrees C with sonicated spin-labed phosphatidylcholine vesicles from which all traces of free fatty acids and lyso derivatives were carefully removed by bovine serum albumin treatment. Phosphatidylcholines 153-172 spindlin 1 Homo sapiens 142-146 178361-7 1976 When spin-labeled phosphatidylcholine, having a nitroxide on the beta chain but near the polar head-group, was incorporated into the erythrocyte membrane, ascorbate treatment at 0 degrees C allows selective reduction of the signal coming from the outer layer of the membrane. Phosphatidylcholines 18-37 spindlin 1 Homo sapiens 5-9 178361-9 1976 The anisotropic distribution of spin-labeled phosphatidylcholine in the erythrocyte membrane was found to be stable at 22 and 37 degrees C for more than 4 h. It is therefore concluded that the rate of outside-inside and inside-outside transition is so slow that the anisotropic distribution of the phospholipids in the erythrocyte membrane can be maintained during cell life. Phosphatidylcholines 45-64 spindlin 1 Homo sapiens 32-36 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 13-32 spindlin 1 Rattus norvegicus 0-4 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 13-32 spindlin 1 Rattus norvegicus 169-173 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 13-32 spindlin 1 Rattus norvegicus 237-241 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 0-4 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 169-173 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 0-4 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 169-173 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 0-4 178362-3 1976 Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver. Phosphatidylcholines 182-201 spindlin 1 Rattus norvegicus 169-173 178362-6 1976 On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane. Phosphatidylcholines 36-55 spindlin 1 Rattus norvegicus 23-27 178362-6 1976 On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane. Phosphatidylcholines 36-55 spindlin 1 Rattus norvegicus 218-222 178362-6 1976 On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane. Phosphatidylcholines 231-250 spindlin 1 Rattus norvegicus 23-27 178362-6 1976 On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane. Phosphatidylcholines 231-250 spindlin 1 Rattus norvegicus 218-222 178362-8 1976 The anisotropic distribution of spin-labeled phosphatidylcholine in the mitochondrial membrane was found to be stable at 25 degrees C for more than 2 h. It is therefore concluded that the rate of outside-inside and inside-outside transitions are extremely slow (half-life greater than 24 h). Phosphatidylcholines 45-64 spindlin 1 Rattus norvegicus 32-36 1252495-2 1976 When platelets, so labelled, were washed and treated with thrombin, there was a major decrease in the radioactivity of phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 119-138 coagulation factor II, thrombin Homo sapiens 58-66 949490-0 1976 Hydrolysis of chylomicron phosphatidylcholine in vitro by lipoprotein lipase, phospholipase A2 and phospholipase C. The effects of lipoprotein lipase, phospholipase A2 and phospholipase C on chylomicron phosphatidylcholine and triacylglycerol were studied with rat lymph chylomicrons containing phosphatidylcholine labeled with [14C]oleic acid. Phosphatidylcholines 26-45 lipoprotein lipase Rattus norvegicus 58-76 949490-0 1976 Hydrolysis of chylomicron phosphatidylcholine in vitro by lipoprotein lipase, phospholipase A2 and phospholipase C. The effects of lipoprotein lipase, phospholipase A2 and phospholipase C on chylomicron phosphatidylcholine and triacylglycerol were studied with rat lymph chylomicrons containing phosphatidylcholine labeled with [14C]oleic acid. Phosphatidylcholines 26-45 phospholipase A2 group IB Rattus norvegicus 78-94 949490-4 1976 Analyses of hydrolytic products showed that lipoprotein lipase cleaved the 1-acyl ester bond of phosphatidylcholine. Phosphatidylcholines 96-115 lipoprotein lipase Rattus norvegicus 44-62 949490-7 1976 The resultant phosphatidylcholine-deficient chylomicrons, which could be concentrated by ultra-centrifugation and resuspended in incubation medium, were readily depleted of triacylglycerol when incubated with lipoprotein lipase. Phosphatidylcholines 14-33 lipoprotein lipase Rattus norvegicus 209-227 178361-3 1976 Spin labeled analogs of phosphatidylcholine were used to study the transverse diffusion (flip-flop) of phospholipids in the erythrocyte membrane. Phosphatidylcholines 24-43 spindlin 1 Homo sapiens 0-4 178361-5 1976 These labeled phosphatidylcholine molecules were incorporated into the membrane by incubation of the red cells at 22 degrees C with sonicated spin-labed phosphatidylcholine vesicles from which all traces of free fatty acids and lyso derivatives were carefully removed by bovine serum albumin treatment. Phosphatidylcholines 14-33 spindlin 1 Homo sapiens 142-146 1174523-1 1975 The phospholipases A2, C and D have been used to investigate the localization of phosphatidylcholine in the phosphatidylcholine exchange protein from beef liver. Phosphatidylcholines 81-100 phospholipase A2 group IB Homo sapiens 4-30 1194272-4 1975 Only small increases in s20 (from 2.67 up to 3.82 X 10(-13) s) and density (from 1.025 up to 1.042 g ml(-1)) were observed upon binding of the cytochrome b5 to phosphatidylcholine vesicles. Phosphatidylcholines 160-179 cytochrome b5 Oryctolagus cuniculus 143-156 1194272-6 1975 Cytochrome b5 was also incubated with phosphatidylcholine vesicles prepared with ferricyanide trapped inside. Phosphatidylcholines 38-57 cytochrome b5 Oryctolagus cuniculus 0-13 1194272-0 1975 Effect of cytochrome b5 on the size, density, and permeability of phosphatidylcholine vesicles. Phosphatidylcholines 66-85 cytochrome b5 Oryctolagus cuniculus 10-23 1194272-1 1975 Cytochrome b5, isolated from rabbit liver by a procedure using detergent, was incubated with phosphatidylcholine bilayer vesicles at 37 degrees for 30 min. Phosphatidylcholines 93-112 cytochrome b5 Oryctolagus cuniculus 0-13 1194272-2 1975 A comparison of a number of physical properties was made between the cytochrome b5-phosphatidylcholine complex (at a molar ratio of 1:1000) and the phosphatidylcholine vesicles. Phosphatidylcholines 83-102 cytochrome b5 Oryctolagus cuniculus 69-82 170257-6 1975 Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol. Phosphatidylcholines 23-43 apolipoprotein A2 Homo sapiens 49-56 170257-6 1975 Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol. Phosphatidylcholines 23-43 apolipoprotein C1 Homo sapiens 58-64 170257-6 1975 Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol. Phosphatidylcholines 23-43 apolipoprotein C3 Homo sapiens 69-77 1174523-1 1975 The phospholipases A2, C and D have been used to investigate the localization of phosphatidylcholine in the phosphatidylcholine exchange protein from beef liver. Phosphatidylcholines 108-127 phospholipase A2 group IB Homo sapiens 4-30 167813-1 1975 The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates. Phosphatidylcholines 169-188 apolipoprotein A1 Homo sapiens 29-35 167813-1 1975 The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates. Phosphatidylcholines 169-188 apolipoprotein C1 Homo sapiens 40-46 167813-1 1975 The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates. Phosphatidylcholines 169-188 lecithin-cholesterol acyltransferase Homo sapiens 91-128 167813-3 1975 The activation by apoA-I and apoC-I differed, depending upon the nature of the hydrocarbon chains of phosphatidylcholine acyl donor. Phosphatidylcholines 101-120 apolipoprotein A1 Homo sapiens 18-24 167813-3 1975 The activation by apoA-I and apoC-I differed, depending upon the nature of the hydrocarbon chains of phosphatidylcholine acyl donor. Phosphatidylcholines 101-120 apolipoprotein C1 Homo sapiens 29-35 167813-4 1975 ApoA-I was most effective with a phosphatidylcholine containing an unsaturated fatty acyl chain. Phosphatidylcholines 33-52 apolipoprotein A1 Homo sapiens 0-6 167813-5 1975 ApoC-I activated LCAT to the same extent with both saturated and unsaturated phosphatidylcholine substrates. Phosphatidylcholines 77-96 apolipoprotein C1 Homo sapiens 0-6 167813-5 1975 ApoC-I activated LCAT to the same extent with both saturated and unsaturated phosphatidylcholine substrates. Phosphatidylcholines 77-96 lecithin-cholesterol acyltransferase Homo sapiens 17-21 1123345-11 1975 Under these conditions the rate of phosphatidylcholine synthesis via this pathway was 20 to 40 percent of that via diacylglycerols and CDP-choline. Phosphatidylcholines 35-54 cut-like homeobox 1 Rattus norvegicus 135-138 173287-1 1975 Hydrolysis of phosphatidylcholine by phospholipase A2 of synaptic membranes i n Tris-CHl buffer was stimulated by cyclic AMP, cyclic GMP, cyclic CMP, cyclic UMP and adenosine (0.1 mm). Phosphatidylcholines 14-33 phospholipase A2 group IB Homo sapiens 37-53 1124312-2 1975 Thin layer and gas liquid chromatographic analysis of the fatty acid methyl esters derived from liver microsomal phosphatidylcholine from animals treated with 14CC1-4 revealed a very similar composition to that observed during the analysis of the reaction products arised by the in vitro benzoyl peroxide initiated CC1-4 chemical addition to double bonds of fatty acid methyl esters or to fatty acids in phospholipids later transformed to methyl esters. Phosphatidylcholines 113-132 C-C motif chemokine ligand 14 Homo sapiens 161-166 168873-5 1975 This indicated that CDP-choline was formed at a similar rate from phosphorylcholine and phosphatidylcholines, the latter probably through the reverse reaction of cholinephosphotransferase (EC 2.7.8.2.). Phosphatidylcholines 88-108 cut-like homeobox 1 Rattus norvegicus 20-23 1120108-0 1975 The binding of deoxycholate, Triton X-100, sodium dodecyl sulfate, and phosphatidylcholine vesicles to cytochrome b5. Phosphatidylcholines 71-90 cytochrome b5 type A Homo sapiens 103-116 1123345-5 1975 The rate of phosphatidylcholine synthesis via the CDP-ester pathway responded in a way analogous to that of phosphatidylethanolamine synthesis upon the addition of choline and fatty acid, except that a 10- to 20-fold higher concentration of choline was required for maximal stimulation, probably due to the rapid oxidation of choline to betaine. Phosphatidylcholines 12-31 cut-like homeobox 1 Rattus norvegicus 50-53 1125185-6 1975 It was, however, substantially reduced when NO3 minus was substituted for Cl minus on the side of the bilayer initially free of 36-Cl, or if I minus was added to the aquesous phases in the concentration range of 0.001-0.1 M. These results strongly suggested that the electrically silent flux of 36-Cl is primarily a carrier mediated diffusion process in which phosphatidylcholine acts as the carrier species. Phosphatidylcholines 360-379 NBL1, DAN family BMP antagonist Homo sapiens 44-47 50420-3 1975 On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine. Phosphatidylcholines 87-106 lipase H Homo sapiens 211-227 50420-3 1975 On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine. Phosphatidylcholines 292-312 lipase H Homo sapiens 211-227 16659017-10 1975 Phosphatidylcholine and phosphatidylethanolamine synthesis paralleled the activity profiles of catalase and malate synthetase, as well as the levels of endogenous diglycerides. Phosphatidylcholines 0-19 catalase isozyme 3 Cucumis sativus 95-103 4407745-0 1974 Hydrolysis of phosphatidylcholine liposomes by pancreatic phospholipase A2 at the transition temperature. Phosphatidylcholines 14-33 phospholipase A2 group IB Homo sapiens 58-74 4474005-0 1974 The activity of phospholipase A2 in reversed micelles of phosphatidylcholine in diethyl ether: effect of water and cations. Phosphatidylcholines 57-76 phospholipase A2 group IB Homo sapiens 16-32 4372633-5 1974 Apolipoprotein A-I preferentially binds phosphatidylcholine, although its lipid-binding capacity is smaller than that of apolipoprotein A-II. Phosphatidylcholines 40-59 apolipoprotein A1 Homo sapiens 0-18 4374941-10 1974 It was concluded that the dietary phosphatidylcholine is hydrolysed in the intestinal lumen by the pancreatic phospholipase A to 1-acylglycerylphosphorylcholine, which on entering the mucosal cell is partly reacylated to phosphatidylcholine, and the rest is further hydrolysed to glycerylphosphorylcholine, glycerophosphate, glycerol and P(i). Phosphatidylcholines 34-53 phospholipase A and acyltransferase 1 Rattus norvegicus 110-125 4374941-10 1974 It was concluded that the dietary phosphatidylcholine is hydrolysed in the intestinal lumen by the pancreatic phospholipase A to 1-acylglycerylphosphorylcholine, which on entering the mucosal cell is partly reacylated to phosphatidylcholine, and the rest is further hydrolysed to glycerylphosphorylcholine, glycerophosphate, glycerol and P(i). Phosphatidylcholines 221-240 phospholipase A and acyltransferase 1 Rattus norvegicus 110-125 4357738-1 1973 Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine. Phosphatidylcholines 91-110 NLR family pyrin domain containing 3 Homo sapiens 51-84 4212407-0 1974 The effect of insulin on the permeability of phosphatidyl choline bimolecular membranes to glucose. Phosphatidylcholines 45-65 insulin Homo sapiens 14-21 4428490-0 1974 Effect of pregnancy and insulin administration on fatty acid distribution in phosphatidylcholine of maternal and fetal liver and lung in the rabbit. Phosphatidylcholines 77-96 insulin Oryctolagus cuniculus 24-31 5158903-11 1971 Insulin decreased the [(14)C]glucose solubilized by phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, but not by sphingomyelin. Phosphatidylcholines 52-71 insulin Homo sapiens 0-7 4341702-2 1972 The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines. Phosphatidylcholines 50-69 rhodopsin Homo sapiens 13-22 4341702-2 1972 The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines. Phosphatidylcholines 176-196 rhodopsin Homo sapiens 13-22 4798723-0 1973 Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: surface dilution kinetics and the effect of thermotropic phase transitions. Phosphatidylcholines 34-53 phospholipase A2 group IB Homo sapiens 0-16 4349484-11 1973 Their abnormal composition is compatible with the possibility that lecithin:cholesterol acyltransferase normally decreases the triglyceride and phosphatidylcholine and increases the cholesteryl ester of very low density and low density plasma lipoproteins in vivo. Phosphatidylcholines 144-163 lecithin-cholesterol acyltransferase Homo sapiens 67-103 4187623-4 1969 This esterification was accomplished by the transfer of fatty acids from the C-2 position of lecithin (phosphatidylcholine) to cholesterol. Phosphatidylcholines 103-122 complement C2 Oryctolagus cuniculus 77-80 5166856-0 1971 [Effect of phospholipase A from snake venom on phosphatidylcholine, phosphatidylethanolamine and on the corresponding plasmalogens. Phosphatidylcholines 47-66 phospholipase A and acyltransferase 1 Homo sapiens 11-26 5388143-2 1969 The interactions between cytochrome c (native and [(14)C]carboxymethylated) and monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin at the air/water interface was investigated by measurements of surface radioactivity, pressure and potential. Phosphatidylcholines 94-113 cytochrome c, somatic Homo sapiens 25-37 5388143-4 1969 On a subphase of 10mm-or m-sodium chloride, penetration of cytochrome c into egg phosphatidylcholine monolayers, as measured by an increase of surface pressure, and the number of molecules penetrating, as judged by surface radioactivity, were inversely proportional to the initial pressure of the monolayer and became zero at 20dynes/cm. Phosphatidylcholines 81-100 cytochrome c, somatic Homo sapiens 59-71 5388143-7 1969 Penetrated cytochrome c could be removed almost entirely by compression of the phosphatidylcholine monolayer above 20dynes/cm. Phosphatidylcholines 79-98 cytochrome c, somatic Homo sapiens 11-23 33713833-4 2021 The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation. Phosphatidylcholines 108-127 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 35-40 33713833-4 2021 The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation. Phosphatidylcholines 129-131 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 35-40 33862056-0 2021 Binding of liposomes composed of phosphatidylcholine to scavenger receptor class B type 1 and its modulation by phosphatidic acid in HEK293T cells. Phosphatidylcholines 33-52 scavenger receptor class B member 1 Homo sapiens 56-89 34023500-13 2021 From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit. Phosphatidylcholines 92-111 RELA proto-oncogene, NF-kB subunit Homo sapiens 150-154 33740632-5 2021 Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-22 33740632-5 2021 Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed. Phosphatidylcholines 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-22 33705949-0 2021 Dietary phosphatidylcholine supplementation reduces atherosclerosis in Ldlr-/- male mice2. Phosphatidylcholines 8-27 low density lipoprotein receptor Mus musculus 71-75 34035440-3 2021 Here, we present the cryo-EM structures of full-length rat IP3R1 reconstituted in lipid nanodisc and detergent solubilized in the presence of phosphatidylcholine determined in ligand-free, closed states by single-particle electron cryo-microscopy. Phosphatidylcholines 142-161 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 59-64 33184906-8 2021 Additionally, chromatography assay evidenced that NTE overexpression significantly reduced the level of phosphatidylcholine (PC) of HUVECs, but NTE shRNA obviously increased the level of PC of HUVECs. Phosphatidylcholines 104-123 patatin like phospholipase domain containing 6 Homo sapiens 50-53 33184906-8 2021 Additionally, chromatography assay evidenced that NTE overexpression significantly reduced the level of phosphatidylcholine (PC) of HUVECs, but NTE shRNA obviously increased the level of PC of HUVECs. Phosphatidylcholines 125-127 patatin like phospholipase domain containing 6 Homo sapiens 50-53 34023500-13 2021 From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit. Phosphatidylcholines 92-111 RELA proto-oncogene, NF-kB subunit Homo sapiens 174-187 34023500-13 2021 From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit. Phosphatidylcholines 113-119 RELA proto-oncogene, NF-kB subunit Homo sapiens 150-154 34023500-13 2021 From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit. Phosphatidylcholines 113-119 RELA proto-oncogene, NF-kB subunit Homo sapiens 174-187 34014977-0 2021 Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways. Phosphatidylcholines 0-19 CREB-H transcription factor homolog let-607 Caenorhabditis elegans 51-58 34014977-0 2021 Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways. Phosphatidylcholines 0-19 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 63-69 34014977-6 2021 SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2. Phosphatidylcholines 63-65 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 84-90 34014977-6 2021 SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2. Phosphatidylcholines 63-65 Inositol 1,4,5-trisphosphate receptor itr-1 Caenorhabditis elegans 99-104 34014977-6 2021 SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2. Phosphatidylcholines 63-65 Protein kinase C;Protein kinase C-like 2 Caenorhabditis elegans 162-167 33545384-3 2021 SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. Phosphatidylcholines 96-115 sphingomyelin synthase 1 Mus musculus 21-51 34003451-7 2021 HSPA8 showed high selectivity for negatively charged phospholipids, such as phosphatidylserine and cardiolipin, and low affinity for phosphatidylcholine. Phosphatidylcholines 133-152 heat shock protein family A (Hsp70) member 8 Homo sapiens 0-5 33945282-8 2021 Our results show that alpha-Syn oligomers grown in the presence of phosphatidylcholine have a distinctly different structure than oligomers grown in the presence of phosphatidylserine. Phosphatidylcholines 67-86 synuclein alpha Homo sapiens 22-31 33955494-6 2021 Enzymatic analysis showed that NPC4 hydrolyzed GIPC and displayed a higher activity toward GIPC as a substrate than toward the common glycerophospholipid phosphatidylcholine. Phosphatidylcholines 154-173 non-specific phospholipase C4 Arabidopsis thaliana 31-35 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 19-48 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 19-48 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 33545384-3 2021 SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. Phosphatidylcholines 96-115 sphingomyelin synthase 1 Mus musculus 53-57 33676699-9 2021 Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 39-83 33676699-9 2021 Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation. Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 85-89 33676699-9 2021 Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Mus musculus 39-83 33676699-9 2021 Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation. Phosphatidylcholines 21-23 phosphatidylethanolamine N-methyltransferase Mus musculus 85-89 33450726-0 2021 Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY. Phosphatidylcholines 58-78 choline/ethanolamine phosphotransferase 1 Homo sapiens 23-28 33617914-2 2021 The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 104-123 patatin like phospholipase domain containing 6 Homo sapiens 52-78 33617914-2 2021 The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 104-123 patatin like phospholipase domain containing 6 Homo sapiens 80-83 33617914-2 2021 The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 125-127 patatin like phospholipase domain containing 6 Homo sapiens 52-78 33617914-2 2021 The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC). Phosphatidylcholines 125-127 patatin like phospholipase domain containing 6 Homo sapiens 80-83 33917451-7 2021 We find that, compared to its C-terminus alone, the full-length perilipin 3 has a higher affinity for both a neat oil/aqueous interface and a phosphatidylcholine (PC) coated oil/aqueous interface. Phosphatidylcholines 142-161 perilipin 3 Homo sapiens 64-75 33917451-7 2021 We find that, compared to its C-terminus alone, the full-length perilipin 3 has a higher affinity for both a neat oil/aqueous interface and a phosphatidylcholine (PC) coated oil/aqueous interface. Phosphatidylcholines 163-165 perilipin 3 Homo sapiens 64-75 33504931-9 2021 In addition, a network of 89 metabolites, primarily phosphatidylcholines, plasmalogens, sphingomyelins, and ceramides showed consistent negative correlations with insulin at visit 1 and post-challenge glucose at visit 2, while positive correlation with adiponectin at visit 2. Phosphatidylcholines 52-72 insulin Homo sapiens 163-170 33504931-9 2021 In addition, a network of 89 metabolites, primarily phosphatidylcholines, plasmalogens, sphingomyelins, and ceramides showed consistent negative correlations with insulin at visit 1 and post-challenge glucose at visit 2, while positive correlation with adiponectin at visit 2. Phosphatidylcholines 52-72 adiponectin, C1Q and collagen domain containing Homo sapiens 253-264 33665770-5 2021 Results from a sulfating activity assay of hSULT1E1 using 1-hydroxypyrene as the substrate demonstrated that Ox-LDL, LPC, and PAF markedly decreased the sulfating activity of hSULT1E1, whereas native LDL and 1-palmitoyl-2-(5"-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC) as one of the oxidized phosphatidylcholines showed the opposite effect. Phosphatidylcholines 299-319 sulfotransferase family 1E member 1 Homo sapiens 175-183 33450726-0 2021 Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY. Phosphatidylcholines 58-78 patatin like phospholipase domain containing 2 Homo sapiens 33-37 33450726-0 2021 Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY. Phosphatidylcholines 58-78 glucokinase Homo sapiens 152-155 33450726-5 2021 At false-discovery rate (FDR) < 0.05, several phosphatidylcholines (PCs) and plasmalogen PCs were specifically increased in GCK-MODY, while triacylglycerols (TAGs) and diacylglycerols (DAGs) were reduced. Phosphatidylcholines 46-66 glucokinase Homo sapiens 124-127 33722607-5 2021 Metabolic labeling experiments reveal that in the absence of exogenously supplied Cho, PE biosynthesized via Psd2 is mostly directed to the methylation pathway for PC biosynthesis and is unavailable for replenishing mitochondrial PE in Psd1-deleted cells. Phosphatidylcholines 164-166 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 109-113 33744860-9 2021 Multiomics analysis revealed glycerophospholipid metabolism to be a common pathway and phosphatidylcholine the main metabolite differentially enriched between the Rb1 and model groups. Phosphatidylcholines 87-106 RB transcriptional corepressor 1 Mus musculus 163-166 33744860-10 2021 Results from fecal transplanted germ-free mice suggest that to suppress hyperlipidemia, Rb1 regulates gut microbiota by regulating the synthesis and decomposition of phosphatidylcholine in glycerophospholipid metabolism, which in turn decreases serum total cholesterol. Phosphatidylcholines 166-185 RB transcriptional corepressor 1 Mus musculus 88-91 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 112-115 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 128-131 33722607-6 2021 In this setting, stimulating the Kennedy pathway for PC biosynthesis by Cho spares Psd2-synthesized PE from the methylation pathway and redirects it to the mitochondria. Phosphatidylcholines 53-55 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 83-87 33606602-10 2021 Daily co-administration of CDP-diacylglycerol significantly enhanced the beneficial effects of CDP-choline and also modified the ATII cell lipidome, reversing the infection-induced decrease in phosphatidylcholine and increasing levels of most other lipid classes in ATII cells. Phosphatidylcholines 193-212 cut like homeobox 1 Homo sapiens 27-30 33439214-6 2021 Moreover, de novo-synthesized phosphatidylcholine is incorporated into autophagosomes preferentially and shows symmetrical distribution in autophagosomes within 30 min after synthesis, whereas this symmetrical distribution is compromised in yeast expressing an Atg9 mutant. Phosphatidylcholines 30-49 autophagy protein ATG9 Saccharomyces cerevisiae S288C 261-265 33672718-2 2021 Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. Phosphatidylcholines 73-92 ATP binding cassette subfamily B member 11 Homo sapiens 26-32 33672718-2 2021 Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. Phosphatidylcholines 73-92 ATP binding cassette subfamily B member 4 Homo sapiens 54-59 33672718-2 2021 Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. Phosphatidylcholines 73-92 ATP binding cassette subfamily B member 1 Homo sapiens 26-31 33672718-2 2021 Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. Phosphatidylcholines 73-92 ATP binding cassette subfamily C member 2 Homo sapiens 164-169 33574922-1 2021 Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 94-113 choline kinase alpha Homo sapiens 0-14 33574922-1 2021 Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 94-113 choline kinase alpha Homo sapiens 16-19 33574922-1 2021 Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 94-113 cut like homeobox 1 Homo sapiens 53-56 33622719-9 2021 Finally, pre-ATI levels of several phosphatidylcholine species (lysophosphatidylcholine precursors) correlated strongly with higher pre-ATI levels of HIV DNA in peripheral CD4+ T cells. Phosphatidylcholines 35-54 CD4 molecule Homo sapiens 172-175 33669841-0 2021 Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFalpha Gene Expression in Macrophages via a cPLA2alpha/COX-1 Pathway. Phosphatidylcholines 0-27 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 107-117 33669841-0 2021 Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFalpha Gene Expression in Macrophages via a cPLA2alpha/COX-1 Pathway. Phosphatidylcholines 0-27 prostaglandin-endoperoxide synthase 1 Mus musculus 118-123 33670702-10 2021 There was a significant increase in cholesteryl ester and phosphatidylcholine content in STAR KO cell lipid droplets, but the most abundant increase was in the amount of diacylglycerol (DAG); DAG 38:1 was the predominantly affected species. Phosphatidylcholines 58-77 steroidogenic acute regulatory protein Mus musculus 89-93 33432959-2 2021 A phosphatidyl choline reversed choline phosphate lipid (CP-Lip) was synthesized and modified with a PD-L1 antibody (CP-alphaPDL). Phosphatidylcholines 2-22 CD274 molecule Homo sapiens 101-106 33673027-7 2021 For instance, LacCer activates an enzyme, cytosolic phospholipase A2 (cPLA2), which cleaves arachidonic acid from phosphatidylcholine. Phosphatidylcholines 114-133 phospholipase A2 group IVA Homo sapiens 42-68 33673027-7 2021 For instance, LacCer activates an enzyme, cytosolic phospholipase A2 (cPLA2), which cleaves arachidonic acid from phosphatidylcholine. Phosphatidylcholines 114-133 phospholipase A2 group IVA Homo sapiens 70-75 33673393-5 2021 A shift of the dominant phospholipid phosphatidylcholine with saturated fatty acids in the DRM to unsaturated species in the non-DRM fractions correlated with the GSL distribution. Phosphatidylcholines 37-56 cathepsin A Homo sapiens 163-166 32888232-7 2021 Finally, serum IgM autoantibodies to double stranded DNA and phosphatidylcholine were increased in resting 10-15 week-old mice lacking GPR43. Phosphatidylcholines 61-80 free fatty acid receptor 2 Mus musculus 135-140 33281496-4 2021 We discovered that phosphatidylcholine bound to rhodopsin with a greater affinity than phosphatidylserine or phosphatidylethanolamine, and that binding of all lipids was influenced by zinc but with different effects. Phosphatidylcholines 19-38 rhodopsin Homo sapiens 48-57 33406839-0 2021 DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor gamma in Lewis Lung Cancer Mice. Phosphatidylcholines 17-36 peroxisome proliferator activated receptor gamma Mus musculus 91-139 33360238-0 2021 The TOC159 null mutant of Arabidopsis thaliana is impaired in the accumulation of plastid lipids and phosphatidylcholine. Phosphatidylcholines 101-120 translocon at the outer envelope membrane of chloroplasts 159 Arabidopsis thaliana 4-10 33360238-5 2021 Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 90-109 proton pump interactor 2 Arabidopsis thaliana 36-40 33360238-5 2021 Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 111-113 proton pump interactor 2 Arabidopsis thaliana 36-40 33521992-5 2021 The promoter regions of LPCAT1 and PCYT1A were hypermethylated, accompanied by downregulation of their messenger RNA expression, which may be involved in the regulation of PCOS through downstream glycerophospholipid metabolism and phosphatidylcholine synthesis. Phosphatidylcholines 231-250 lysophosphatidylcholine acyltransferase 1 Homo sapiens 24-30 33521992-5 2021 The promoter regions of LPCAT1 and PCYT1A were hypermethylated, accompanied by downregulation of their messenger RNA expression, which may be involved in the regulation of PCOS through downstream glycerophospholipid metabolism and phosphatidylcholine synthesis. Phosphatidylcholines 231-250 phosphate cytidylyltransferase 1A, choline Homo sapiens 35-41 33525659-8 2021 However, seven lipid species, including phosphatidylcholines, phosphatidylethanolamines, and triacylglycerol, were downregulated in the ELOVL5-Mo-derived blastocysts compared with the biological control. Phosphatidylcholines 40-60 ELOVL fatty acid elongase 5 Homo sapiens 136-142 33451008-2 2021 Interactions between hBest1, sphingomyelins, phosphatidylcholines and cholesterol are crucial for hBest1 association with cell membrane domains and its biological functions. Phosphatidylcholines 45-65 bestrophin 1 Homo sapiens 98-104 33415971-8 2021 Although phosphatidylcholine (PC) is the most abundant lipid species in mammalian cells, interactions of PC with alpha-syn have been largely ignored because they are substantially weaker compared with the electrostatically driven binding of negatively charged lipids. Phosphatidylcholines 105-107 synuclein alpha Homo sapiens 113-122 33462674-8 2021 Generalised protection from HFD-induced lipid accumulation was observed in CD248 null mice compared to wildtype, with particular reduction noted in the lysophosphatidylcholines, phosphatidylcholines, cholesterol and carnitine. Phosphatidylcholines 156-176 CD248 antigen, endosialin Mus musculus 75-80 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 296-315 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 227-232 33431899-0 2021 High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Phosphatidylcholines 47-66 insulin Homo sapiens 82-89 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 145-164 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 0-45 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 145-164 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 47-52 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 296-315 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 320-337 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 145-164 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 227-232 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 145-164 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 320-337 32828847-1 2021 Sec14, a yeast phosphatidylinositol/phosphatidylcholine transfer protein, functions at the trans-Golgi membranes. Phosphatidylcholines 36-55 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 296-315 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 0-45 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). Phosphatidylcholines 296-315 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 47-52 33296468-11 2021 Negative associations of kynurenic acid, 22:1 sphingomyelin, and 38:6 phosphatidylethanolamine, as well as positive associations of 32:1 phosphatidylcholine with GI and GL were also observed. Phosphatidylcholines 137-156 G protein subunit alpha i1 Homo sapiens 162-164 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidylcholines 65-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 33107656-2 2021 The expression of Ricinus communis (castor) OLEATE 12-HYDROXYLASE (RcFAH12) in Arabidopsis has resulted in only limited accumulation of HFA in seeds, which likely results from inefficient transfer of HFAs from their site of synthesis (phosphatidylcholine; PC) to triacylglycerol (TAG), especially at the sn-1/3 positions of TAG. Phosphatidylcholines 235-254 oleate hydroxylase FAH12 Ricinus communis 67-74 33383947-2 2020 Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 11 Homo sapiens 91-97 33383947-2 2020 Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 4 Homo sapiens 133-138 32778895-5 2020 Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransferase (PEMT) pathways for PC synthesis were assessed from incorporations of deuterated methyl-D9-choline chloride. Phosphatidylcholines 127-129 phosphatidylethanolamine N-methyltransferase Homo sapiens 62-106 32778895-5 2020 Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransferase (PEMT) pathways for PC synthesis were assessed from incorporations of deuterated methyl-D9-choline chloride. Phosphatidylcholines 127-129 phosphatidylethanolamine N-methyltransferase Homo sapiens 108-112 32778895-7 2020 Direct incorporation of methyl-D9-choline demonstrated that this transition was driven by an active CDP-choline pathway that synthesized PC enriched in species containing oleic and linoleic acids. Phosphatidylcholines 137-139 cut like homeobox 1 Homo sapiens 100-103 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. Phosphatidylcholines 0-19 Ras and Rab interactor 2 Homo sapiens 76-80 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. Phosphatidylcholines 0-19 Ras and Rab interactor 2 Homo sapiens 127-131 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. Phosphatidylcholines 0-19 phospholipase A2 group V Homo sapiens 138-144 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. Phosphatidylcholines 21-23 Ras and Rab interactor 2 Homo sapiens 76-80 33060204-6 2020 The primary substrates of Dnf2 are glucosylceramide (GlcCer) and phosphatidylcholine ((PC) or their lyso-lipid derivatives), and we find that these substrates compete with each other for transport. Phosphatidylcholines 65-84 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 26-30 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. Phosphatidylcholines 171-190 cut like homeobox 1 Homo sapiens 42-45 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. Phosphatidylcholines 171-190 cut like homeobox 1 Homo sapiens 58-61 33289390-0 2020 Phosphatidylcholine Ameliorates LPS-Induced Systemic Inflammation and Cognitive Impairments via Mediating the Gut-Brain Axis Balance. Phosphatidylcholines 0-19 glucuronidase, beta Mus musculus 110-113 33289390-2 2020 Phosphatidylcholine (PC) is a phospholipid found in egg yolk that has anti-inflammatory and antioxidant properties. Phosphatidylcholines 0-19 pyruvate carboxylase Mus musculus 21-23 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidylcholines 65-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidylcholines 65-84 phospholipase D1 Homo sapiens 31-37 32917728-0 2020 Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid. Phosphatidylcholines 68-87 dynein axonemal heavy chain 8 Homo sapiens 19-25 32917728-0 2020 Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid. Phosphatidylcholines 68-87 ATP binding cassette subfamily B member 4 Homo sapiens 38-42 32917728-0 2020 Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid. Phosphatidylcholines 68-87 ATP binding cassette subfamily B member 4 Homo sapiens 43-48 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 103-105 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 103-105 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 33160274-3 2020 More intriguingly, the disruption of p53 in hESCs leads to dramatic upregulation of phosphatidylcholine and decrease of total choline in both pluripotent and differentiated state of hESCs, suggesting abnormal choline metabolism in the absence of p53. Phosphatidylcholines 84-103 tumor protein p53 Homo sapiens 37-40 32912785-5 2020 PEMT converts PE into PC using methyl group by S-adenosylmethionine (SAM) thus converted in S-adenosylhomocysteine (SAH). Phosphatidylcholines 22-24 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-4 33256620-2 2020 This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane. Phosphatidylcholines 114-133 ATP binding cassette subfamily B member 4 Homo sapiens 18-48 33256620-2 2020 This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane. Phosphatidylcholines 114-133 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 33658925-6 2020 The cytosolic phospholipase A2a (PLA2G4A), an enzyme for hydrolyzing PC to LPC, was found to be up-regulated in the colon tissue of experimental colitis mice and inflamed macrophage RAW 264.7 cells. Phosphatidylcholines 69-71 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 33-40 32943187-3 2020 In this study, we proposed 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), the main active species of PPC, as an effective substance for the treatment of obesity-mediated disorders such as impaired fat metabolism and insulin resistance. Phosphatidylcholines 106-109 insulin Homo sapiens 221-228 33227003-6 2020 Mass spectrometry analysis revealed elevated levels of major phosphatidylcholine and phosphatidylethanolamine species in fat bodies with active Toll signaling. Phosphatidylcholines 61-80 Toll Drosophila melanogaster 144-148 33141558-4 2020 We find that NPC2 binds fluorescence- and spin-labeled analogues of phosphatidylcholine (PC), phosphatidylserine, phosphatidylinositol (PI), and sphingomyelin. Phosphatidylcholines 68-87 sterol transporter Saccharomyces cerevisiae S288C 13-17 33208465-4 2021 Mechanistically, sublethal DNA damage unexpectedly suppresses apoptotic genes in C. elegans, which in turn increases the activity of the IRE-1/XBP-1 branch of the UPRER by elevating unsaturated phosphatidylcholine (PC). Phosphatidylcholines 215-217 Endoribonuclease;Serine/threonine-protein kinase Caenorhabditis elegans 137-142 33208465-4 2021 Mechanistically, sublethal DNA damage unexpectedly suppresses apoptotic genes in C. elegans, which in turn increases the activity of the IRE-1/XBP-1 branch of the UPRER by elevating unsaturated phosphatidylcholine (PC). Phosphatidylcholines 215-217 BZIP domain-containing protein Caenorhabditis elegans 143-148 33141558-6 2020 We further identify ergosterol, PC, and PI as endogenous NPC2 ligands. Phosphatidylcholines 32-34 sterol transporter Saccharomyces cerevisiae S288C 57-61 32868075-1 2020 Phosphatidylcholine-specific phospholipase Cgamma1 (PLCgamma1) is involved in regulating cell metabolism. Phosphatidylcholines 0-19 phospholipase C, gamma 1 Rattus norvegicus 52-61 33312389-13 2020 There were significant increase in the contents of several phosphatidylcholines, lysophosphatidylcholine, free fatty acids and carnitine in AR rats which detected by HPLC/MS. Phosphatidylcholines 59-79 ferredoxin reductase Rattus norvegicus 140-142 33312389-15 2020 Metabolomic studies indicated a significant increase in AR rats in the contents of several metabolites, such as phosphatidylcholines, lysophosphatidylcholine, free fatty acids and carnitine, suggesting an increasein phospholipase activity and leading to an energy metabolism imbalance with intensification of beta-oxidation. Phosphatidylcholines 112-132 ferredoxin reductase Rattus norvegicus 56-58 33312389-16 2020 DNA methylation may be associated with an increase in phosphatidylcholines, lysophosphatidylcholine and free fatty acids in AR rats, which may further affect energy metabolism by enhancing the tricarboxylic acid cycle in AR rats. Phosphatidylcholines 54-74 ferredoxin reductase Rattus norvegicus 124-126 33312389-16 2020 DNA methylation may be associated with an increase in phosphatidylcholines, lysophosphatidylcholine and free fatty acids in AR rats, which may further affect energy metabolism by enhancing the tricarboxylic acid cycle in AR rats. Phosphatidylcholines 54-74 ferredoxin reductase Rattus norvegicus 221-223 33184653-12 2021 Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans" offspring compared to placebo. Phosphatidylcholines 0-19 renin binding protein Homo sapiens 42-45 33184653-12 2021 Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans" offspring compared to placebo. Phosphatidylcholines 0-19 renin binding protein Homo sapiens 152-155 32766878-10 2020 The differential abundance of phosphatidylcholines we found can be attributed at least partially to higher expression of phosphatidylethanolamine methyl transferase (PEMT). Phosphatidylcholines 30-50 phosphatidylethanolamine N-methyltransferase Homo sapiens 121-164 33084321-0 2020 Immobilized Phospholipase A1-Catalyzed Preparation of l-alpha-Glycerylphosphorylcholine from Phosphatidylcholine. Phosphatidylcholines 93-112 lipase H Homo sapiens 12-28 33084321-1 2020 This study sought to prepare a cognitive enhancer l-alpha-glycerylphosphorylcholine (l-alpha-GPC) using an immobilized Lecitase Ultra (LU, phospholipase A1) to catalyze the hydrolysis of soy phosphatidylcholine (PC). Phosphatidylcholines 191-210 lipase H Homo sapiens 119-155 33084321-1 2020 This study sought to prepare a cognitive enhancer l-alpha-glycerylphosphorylcholine (l-alpha-GPC) using an immobilized Lecitase Ultra (LU, phospholipase A1) to catalyze the hydrolysis of soy phosphatidylcholine (PC). Phosphatidylcholines 94-96 lipase H Homo sapiens 119-155 32845134-0 2020 Identification of Phosphatidylcholine Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions. Phosphatidylcholines 18-37 gastrin Rattus norvegicus 81-84 32766878-10 2020 The differential abundance of phosphatidylcholines we found can be attributed at least partially to higher expression of phosphatidylethanolamine methyl transferase (PEMT). Phosphatidylcholines 30-50 phosphatidylethanolamine N-methyltransferase Homo sapiens 166-170 32780898-6 2020 Through lipidomic analysis, 46 lipids were differentially expressed in hyperuricemic mouse livers, and the phosphatidylcholine composition was altered, which was mediated by LPCAT3 upregulation. Phosphatidylcholines 107-126 lysophosphatidylcholine acyltransferase 3 Mus musculus 174-180 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). Phosphatidylcholines 138-157 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). Phosphatidylcholines 138-157 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). Phosphatidylcholines 159-161 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). Phosphatidylcholines 159-161 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 32735863-11 2020 We then conditioned ACAT1 with phosphatidylcholine (PC) to replace CHAPS prior to the formation of ACAT1 peptidiscs. Phosphatidylcholines 52-54 acetyl-CoA acetyltransferase 1 Homo sapiens 20-25 32917955-3 2020 By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cells, we identified a group of super enhancers (SEs) that are abnormally activated in Enz-resistant CRPC cells and associated with enhanced transcription of a subset of tumor promoting genes such as CHPT1, which catalyzes phosphatidylcholine (PtdCho) synthesis and regulates choline metabolism. Phosphatidylcholines 303-322 choline phosphotransferase 1 Mus musculus 280-285 32917955-3 2020 By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cells, we identified a group of super enhancers (SEs) that are abnormally activated in Enz-resistant CRPC cells and associated with enhanced transcription of a subset of tumor promoting genes such as CHPT1, which catalyzes phosphatidylcholine (PtdCho) synthesis and regulates choline metabolism. Phosphatidylcholines 324-330 choline phosphotransferase 1 Mus musculus 280-285 32732347-7 2020 AtDGAT1 produces TAG from a rapidly produced phosphatidylcholine (PC)-derived DAG pool. Phosphatidylcholines 45-64 membrane bound O-acyl transferase (MBOAT) family protein Arabidopsis thaliana 0-7 32732347-7 2020 AtDGAT1 produces TAG from a rapidly produced phosphatidylcholine (PC)-derived DAG pool. Phosphatidylcholines 66-68 membrane bound O-acyl transferase (MBOAT) family protein Arabidopsis thaliana 0-7 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32737074-7 2020 We reasoned that the castor LPCAT (RcLPCAT) would preferentially remove HFA from PC resulting in greater incorporation onto TAG. Phosphatidylcholines 29-31 lysophospholipid acyltransferase 1 Ricinus communis 35-42 32735863-11 2020 We then conditioned ACAT1 with phosphatidylcholine (PC) to replace CHAPS prior to the formation of ACAT1 peptidiscs. Phosphatidylcholines 52-54 acetyl-CoA acetyltransferase 1 Homo sapiens 99-104 32735863-12 2020 The results showed, when PC was included, ACAT1 was present mainly in higher-order oligomeric states with greater enzymatic activity. Phosphatidylcholines 25-27 acetyl-CoA acetyltransferase 1 Homo sapiens 42-47 32735863-13 2020 With PC present, the enzymatic activity of ACAT1 peptidiscs was protected from heat-mediated inactivation. Phosphatidylcholines 5-7 acetyl-CoA acetyltransferase 1 Homo sapiens 43-48 33083764-3 2020 Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs. Phosphatidylcholines 113-132 fatty acid synthase Homo sapiens 53-57 32966473-0 2020 Exogenous natural EPA-enriched phosphatidylcholine and phosphatidylethanolamine ameliorate lipid accumulation and insulin resistance via activation of PPARalpha/gamma in mice. Phosphatidylcholines 31-50 peroxisome proliferator activated receptor alpha Mus musculus 151-160 32966473-2 2020 Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma. Phosphatidylcholines 66-85 peroxisome proliferator activated receptor alpha Mus musculus 170-179 32966473-2 2020 Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma. Phosphatidylcholines 66-85 peroxisome proliferator activated receptor gamma Mus musculus 180-189 33083764-3 2020 Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs. Phosphatidylcholines 134-136 fatty acid synthase Homo sapiens 53-57 33083764-3 2020 Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs. Phosphatidylcholines 163-165 fatty acid synthase Homo sapiens 53-57 32471727-0 2020 MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Phosphatidylcholines 42-62 mitochondrial amidoxime reducing component 1 Homo sapiens 0-5 32705322-2 2020 In this study, the interaction between phloretin and human serum albumin (HSA) in an L-egg lecithin phosphatidylcholine (PC) liposome suspension was investigated by fluorescence and absorbance spectroscopy. Phosphatidylcholines 121-123 albumin Homo sapiens 59-72 32662451-5 2020 Distinction between normal control (NC) and acute beta-adrenergic receptor (beta-AR) activation-induced SCD groups was primarily due to the changes of diacylglycerols (DAG), phosphatidylcholine (PC), lysophosphatidylcholine (LysoPC) and sphingomyelin (SM) in positive mode. Phosphatidylcholines 195-197 adrenergic receptor, beta 1 Mus musculus 76-83 32491269-0 2020 Testosterone replacement therapy in insulin-sensitive hypogonadal men restores phosphatidylcholine levels by regulation of arachidonic acid metabolism. Phosphatidylcholines 79-98 insulin Homo sapiens 36-43 32703435-2 2020 It is emerging that PCYT1A, a rate-limiting enzyme required for the biosynthesis of phosphatidylcholine, is associated with cancer progression. Phosphatidylcholines 84-103 phosphate cytidylyltransferase 1A, choline Homo sapiens 20-26 32628014-11 2020 These results indicate that sphingomyelin and phosphatidylcholine lipids can act as charge-reducing agents when dissociated from native membrane protein-lipid complexes in the gas phase and provide a straightforward model to explain the results of several recent native mass spectrometry studies of protein-lipid complexes. Phosphatidylcholines 46-65 gastrin Homo sapiens 176-179 32304789-2 2020 Hence, chitosan nanoparticles (CS NPs), phosphatidylcholine and gentamicin were used to synthesize a novel nanodrug delivery system (GPC NPs). Phosphatidylcholines 40-59 glycophorin C (Gerbich blood group) Homo sapiens 133-136 32760418-5 2020 It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis. Phosphatidylcholines 106-125 fatty acid desaturase 2 Arabidopsis thaliana 18-22 32760418-5 2020 It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis. Phosphatidylcholines 106-125 fatty acid desaturase 2 Arabidopsis thaliana 24-47 32760418-5 2020 It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis. Phosphatidylcholines 127-129 fatty acid desaturase 2 Arabidopsis thaliana 18-22 32760418-5 2020 It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis. Phosphatidylcholines 127-129 fatty acid desaturase 2 Arabidopsis thaliana 24-47 32694752-2 2020 Given the anti-inflammatory role of the cytokine IL-10, we investigated its modulatory effect on the production of oxidized phosphatidylcholines (OxPCs) as well as lipid metabolic responses in global myocardial ischemia/reperfusion (I/R) injury. Phosphatidylcholines 124-144 interleukin 10 Homo sapiens 49-54 32708453-4 2020 Phosphatidylcholines (PC) and molecules of the sphingomyelin (SM) family exhibited the strongest anti-PAF effects, followed by phosphatidylethanolamines (PE). Phosphatidylcholines 0-20 PCNA clamp associated factor Homo sapiens 102-105 32708453-4 2020 Phosphatidylcholines (PC) and molecules of the sphingomyelin (SM) family exhibited the strongest anti-PAF effects, followed by phosphatidylethanolamines (PE). Phosphatidylcholines 22-24 PCNA clamp associated factor Homo sapiens 102-105 32708453-5 2020 PC contained higher amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and thus the lowest n-6/n-3 ratio. Phosphatidylcholines 0-2 pumilio RNA binding family member 3 Homo sapiens 72-76 32708453-6 2020 Bioactive diacyl and alkyl-acyl PC and PE molecules bearing n-3 PUFA at their sn-2 position, especially docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA) but mostly oleic acid (OA), were identified in both PC and PE subclasses. Phosphatidylcholines 32-34 pumilio RNA binding family member 3 Homo sapiens 64-68 32637097-9 2020 BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio. Phosphatidylcholines 93-112 BTN1A1 Bos taurus 0-6 32637097-9 2020 BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio. Phosphatidylcholines 114-116 BTN1A1 Bos taurus 0-6 32491269-3 2020 Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC). Phosphatidylcholines 113-132 phospholipase A2 group IB Homo sapiens 170-186 32491269-3 2020 Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC). Phosphatidylcholines 134-136 phospholipase A2 group IB Homo sapiens 170-186 31991038-5 2020 AtROD1 encodes phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), the enzyme that catalyzes a major flux of polyunsaturated fatty acids (PUFA) in oil synthesis. Phosphatidylcholines 15-34 phosphatidic acid phosphatase-related / PAP2-like protein Arabidopsis thaliana 0-6 32172343-4 2020 We established that ATP10B encodes a late endo-lysosomal lipid flippase that translocates the lipids glucosylceramide (GluCer) and phosphatidylcholine (PC) towards the cytosolic membrane leaflet. Phosphatidylcholines 131-150 ATPase phospholipid transporting 10B (putative) Homo sapiens 20-26 32666045-0 2020 Overactive EGF signaling promotes uv1 cell survival via increased phosphatidylcholine levels and suppression of SBP-1. Phosphatidylcholines 66-85 LOW QUALITY PROTEIN: pro-epidermal growth factor Cricetulus griseus 11-14 32625095-10 2020 The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups. Phosphatidylcholines 155-174 interleukin 6 Rattus norvegicus 45-49 32625095-10 2020 The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups. Phosphatidylcholines 155-174 tumor necrosis factor Rattus norvegicus 50-59 32625095-10 2020 The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups. Phosphatidylcholines 155-174 interleukin 6 Rattus norvegicus 233-237 32625095-10 2020 The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups. Phosphatidylcholines 155-174 tumor necrosis factor Rattus norvegicus 238-247 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). Phosphatidylcholines 140-159 phosphatidylethanolamine N-methyltransferase Mus musculus 57-101 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). Phosphatidylcholines 140-159 phosphatidylethanolamine N-methyltransferase Mus musculus 103-107 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). Phosphatidylcholines 161-163 phosphatidylethanolamine N-methyltransferase Mus musculus 57-101 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). Phosphatidylcholines 161-163 phosphatidylethanolamine N-methyltransferase Mus musculus 103-107 32521649-10 2020 Reduced MTHFR protein in the livers of FASD mothers and male pups resulted in choline/methyl metabolite disruptions in offspring liver (decreased betaine) and brain (decreased glycerophosphocholine and sphingomyelin in male pups, and decreased phosphatidylcholine in both sexes). Phosphatidylcholines 244-263 methylenetetrahydrofolate reductase Mus musculus 8-13 32393038-2 2020 In our previous studies, we found that even a small amount of beta-sitosteryl sulfate (PSO4) significantly affects the phase behavior, hydration properties, and liposomal properties of pure saturated phosphatidylcholines (Kafle, et al, Colloids Surf. Phosphatidylcholines 200-220 pre-mRNA processing factor 19 Homo sapiens 87-91 32393038-10 2020 Upon addition of PSO4, at room temperature, the PC fraction gradually converted into the liquid ordered (Lo) phase while the (PE + PA) fraction remained unaffected. Phosphatidylcholines 48-50 pre-mRNA processing factor 19 Homo sapiens 17-21 32172343-4 2020 We established that ATP10B encodes a late endo-lysosomal lipid flippase that translocates the lipids glucosylceramide (GluCer) and phosphatidylcholine (PC) towards the cytosolic membrane leaflet. Phosphatidylcholines 152-154 ATPase phospholipid transporting 10B (putative) Homo sapiens 20-26 31517566-2 2020 Using 13C-labeled choline and 13C-magnetic resonance spectroscopy and western blotting, we show increased de novo choline phospholipid (ChoPL) production and activation of PCYT1A (phosphate cytidylyltransferase 1, choline, alpha), the rate-limiting enzyme of phosphatidylcholine (PtdCho) synthesis, during autophagy. Phosphatidylcholines 259-278 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 172-178 31517566-2 2020 Using 13C-labeled choline and 13C-magnetic resonance spectroscopy and western blotting, we show increased de novo choline phospholipid (ChoPL) production and activation of PCYT1A (phosphate cytidylyltransferase 1, choline, alpha), the rate-limiting enzyme of phosphatidylcholine (PtdCho) synthesis, during autophagy. Phosphatidylcholines 280-286 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 172-178 32287294-8 2020 In a cell line representing HER2-overexpressing tumor subtype an elevated expression of TG (<= C-46), phosphatidylcholines (PC) and PE containing short-chained (<= C-16) saturated or monounsaturated fatty acids were observed. Phosphatidylcholines 102-122 erb-b2 receptor tyrosine kinase 2 Homo sapiens 28-32 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 104-123 phosphate cytidylyltransferase 1A, choline Homo sapiens 0-45 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 104-123 phosphate cytidylyltransferase 1A, choline Homo sapiens 47-55 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 104-123 phosphate cytidylyltransferase 1B, choline Homo sapiens 61-68 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 125-127 phosphate cytidylyltransferase 1A, choline Homo sapiens 0-45 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 125-127 phosphate cytidylyltransferase 1A, choline Homo sapiens 47-55 32186954-1 2020 CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 125-127 phosphate cytidylyltransferase 1B, choline Homo sapiens 61-68 32176333-4 2020 NPC6 is associated with the chloroplasts and microsomal membranes, and hydrolyzes phosphatidylcholine and galactolipids to produce diacylglycerol. Phosphatidylcholines 82-101 non-specific phospholipase C6 Arabidopsis thaliana 0-4 32316172-0 2020 Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia. Phosphatidylcholines 94-114 NUT midline carcinoma, family member 1 Mus musculus 6-9 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 38-42 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 85-89 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 85-89 32084434-2 2020 LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2). Phosphatidylcholines 36-55 phospholipase A2 group IB Homo sapiens 59-75 32084434-2 2020 LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2). Phosphatidylcholines 36-55 phospholipase A2 group IB Homo sapiens 77-81 32287294-8 2020 In a cell line representing HER2-overexpressing tumor subtype an elevated expression of TG (<= C-46), phosphatidylcholines (PC) and PE containing short-chained (<= C-16) saturated or monounsaturated fatty acids were observed. Phosphatidylcholines 124-126 erb-b2 receptor tyrosine kinase 2 Homo sapiens 28-32 30389273-7 2020 Rhodioloside administration showed atheroprotective effects on the apoE-/- mice with regulating the levels of 1 phosphatidylcholine, 2 phosphatidylserines, 5 alkyldiacylglycerols and 3 alkenyldiacylglycerols back to normal. Phosphatidylcholines 112-131 apolipoprotein E Mus musculus 67-71 32107839-6 2020 Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals. Phosphatidylcholines 135-154 phospholipase A2 group IVB Homo sapiens 46-53 32107839-6 2020 Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals. Phosphatidylcholines 135-154 arachidonate 15-lipoxygenase type B Homo sapiens 58-65 32107839-6 2020 Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals. Phosphatidylcholines 223-242 phospholipase A2 group IVB Homo sapiens 46-53 32107839-6 2020 Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals. Phosphatidylcholines 223-242 arachidonate 15-lipoxygenase type B Homo sapiens 58-65 32055910-10 2020 Upon stimulation, diacylglycerides, hexosylceramides, phosphatidylcholines, phosphoethanolamines, and lysophosphoethanolamines were upregulated in CD4+ cells and PMNs, whereas CD14+ cells did not show significant changes. Phosphatidylcholines 54-74 CD4 molecule Homo sapiens 147-150 32234213-5 2020 In addition to allosterically activating IQSec1, ORP3 also extracts PI4P from the PM, in exchange for phosphatidylcholine. Phosphatidylcholines 102-121 IQ motif and Sec7 domain ArfGEF 1 Homo sapiens 41-47 32234213-5 2020 In addition to allosterically activating IQSec1, ORP3 also extracts PI4P from the PM, in exchange for phosphatidylcholine. Phosphatidylcholines 102-121 oxysterol binding protein like 3 Homo sapiens 49-53 32008771-13 2020 The changes observed in muscle lysophosphatidylcholine and phosphatidylcholine concentrations may point to an alteration in phosphatidylcholine metabolism, probably resulting in an increase in membrane stiffness, which may lead to abnormalities in insulin signaling in the muscle of over-conditioned cows. Phosphatidylcholines 59-78 insulin Bos taurus 248-255 32198492-1 2020 The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. Phosphatidylcholines 66-85 phospholipase D1 Homo sapiens 31-47 32198492-1 2020 The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. Phosphatidylcholines 66-85 phospholipase D1 Homo sapiens 49-53 32198481-4 2020 The hNM lipid extract was composed of a complex mixture of phospholipids, with high amounts of phosphatidylcholines, phosphatidylinositols (PI) and cholesterol. Phosphatidylcholines 95-115 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 4-7 32020064-7 2020 Furthermore, several altered peaks on mass spectra were identified as phosphatidylcholine species in TGF-beta-stimulated HNSCC cells. Phosphatidylcholines 70-89 transforming growth factor alpha Homo sapiens 101-109 32071354-0 2020 The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts. Phosphatidylcholines 4-23 START domain containing 7 Mus musculus 41-47 31355949-2 2020 Previous studies identified phosphatidylcholines as potential endogenous agonist ligands for LRH-1. Phosphatidylcholines 28-48 nuclear receptor subfamily 5, group A, member 2 Mus musculus 93-98 31355949-3 2020 In the liver, distinct subsets of phosphatidylcholine species are generated by two different pathways: choline addition to phosphatidic acid through the Kennedy pathway and trimethylation of phosphatidylethanolamine through phosphatidylethanolamine N-methyl transferase (PEMT). Phosphatidylcholines 34-53 phosphatidylethanolamine N-methyltransferase Mus musculus 224-269 31355949-3 2020 In the liver, distinct subsets of phosphatidylcholine species are generated by two different pathways: choline addition to phosphatidic acid through the Kennedy pathway and trimethylation of phosphatidylethanolamine through phosphatidylethanolamine N-methyl transferase (PEMT). Phosphatidylcholines 34-53 phosphatidylethanolamine N-methyltransferase Mus musculus 271-275 31355949-6 2020 In contrast, activation of LRH-1 by its phosphatidylcholine agonists exerts opposite effects. Phosphatidylcholines 40-59 nuclear receptor subfamily 5, group A, member 2 Mus musculus 27-32 32121031-2 2020 To perform the assay, an aliquot of a PLD standard solution is typically added to borate buffer containing phosphatidylcholine at a certain concentration and the oxidation current of hydrogen peroxide is then measured at the rotating modified electrode by applying a detection potential of + 0.7 V vs. SCE. Phosphatidylcholines 107-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 31757360-6 2020 First, a computational modeling approach by coarse-grained molecular dynamics simulation of the whole TRPV1 embedded in a phosphatidylcholine and phosphatidylethanolamine membrane provides insight into the dynamics of this channel domain. Phosphatidylcholines 122-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 32071354-1 2020 StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration. Phosphatidylcholines 12-31 START domain containing 7 Mus musculus 0-6 32071354-1 2020 StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration. Phosphatidylcholines 33-35 START domain containing 7 Mus musculus 0-6 32071354-1 2020 StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration. Phosphatidylcholines 116-118 START domain containing 7 Mus musculus 0-6 32071354-7 2020 The reduction in mitochondrial PC levels and oxygen consumption rates, decreased expression of myomaker, myomerger and PGC-1alpha, as well as impaired myogenic differentiation, were completely restored when the protein was reintroduced into StarD7-knockout C2C12 cells. Phosphatidylcholines 31-33 START domain containing 7 Mus musculus 241-247 31647997-1 2020 Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature. Phosphatidylcholines 169-188 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 0-8 31647997-1 2020 Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature. Phosphatidylcholines 169-188 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 34-37 31647997-1 2020 Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature. Phosphatidylcholines 190-192 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 0-8 31647997-1 2020 Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature. Phosphatidylcholines 190-192 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 34-37 31864675-7 2020 The proliferation and differentiation levels of osteoprogenetor cells were enhanced and ALP was strongly expressed in the groups grafted with phosphatidylcholine and COL I. Phosphatidylcholines 142-161 alkaline phosphatase, placental Homo sapiens 88-91 32082314-10 2020 Administration of colony stimulating factor 2 (CSF-2), a critical factor in AM development and maintenance, increased AM numbers in CD44-/- mice and decreased phosphatidylcholine levels in the bronchoalveolar lavage, but was unable to decrease intracellular lipid accumulation in CD44-/- AMs. Phosphatidylcholines 159-178 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 18-45 32082314-10 2020 Administration of colony stimulating factor 2 (CSF-2), a critical factor in AM development and maintenance, increased AM numbers in CD44-/- mice and decreased phosphatidylcholine levels in the bronchoalveolar lavage, but was unable to decrease intracellular lipid accumulation in CD44-/- AMs. Phosphatidylcholines 159-178 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 47-52 31739040-6 2020 Both enzymes have improved thermostability compared to mammalian pancreatic sPLA2 since they are active and stable at 55 C, with specific activities of 320 and 190 U mg-1 measured on phosphatidylcholine, respectively. Phosphatidylcholines 184-203 phospholipase A2 group IIA Homo sapiens 76-81 31678520-4 2020 Most transferosomes contain phosphatidylcholine (C18) as it is the most abundant lipid component of the cell membrane, and hence, it is highly tolerated for the skin, decreasing the risk of undesirable effects, such as hypersensitive reactions. Phosphatidylcholines 28-47 Bardet-Biedl syndrome 9 Homo sapiens 49-52 31826940-5 2020 Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells. Phosphatidylcholines 71-90 TNF receptor-associated factor 3 Mus musculus 129-134 31826940-5 2020 Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells. Phosphatidylcholines 71-90 TNF receptor-associated factor 3 Mus musculus 170-175 31826940-7 2020 Taken together, our results indicate that enhanced phosphocholine and phosphatidylcholine synthesis supports the prolonged survival of Traf3 -/- B lymphocytes. Phosphatidylcholines 70-89 TNF receptor associated factor 3 Homo sapiens 135-140 31770533-13 2020 Furthermore, transformation from choline to phosphatidylcholine regulated by miR-106a-5p was also disrupted, resulting in phosphatidic choline synthesis disorder and reduced cell membrane synthesis. Phosphatidylcholines 44-63 microRNA 106a Homo sapiens 77-85 31918922-1 2020 OBJECTIVE: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Phosphatidylcholines 71-90 phosphatidylethanolamine N-methyltransferase Mus musculus 55-59 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidylcholines 66-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidylcholines 66-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 32086667-4 2020 PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate. Phosphatidylcholines 39-58 phospholipase D1 Homo sapiens 0-4 32086667-4 2020 PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate. Phosphatidylcholines 39-58 phospholipase D2 Homo sapiens 9-13 32086667-4 2020 PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate. Phosphatidylcholines 60-62 phospholipase D1 Homo sapiens 0-4 32086667-4 2020 PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate. Phosphatidylcholines 60-62 phospholipase D2 Homo sapiens 9-13 31918922-1 2020 OBJECTIVE: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Phosphatidylcholines 92-94 phosphatidylethanolamine N-methyltransferase Mus musculus 55-59 31348857-4 2019 Our results reveal that the PC lipids could attach to the PEO either as vesicles or as bilayers, depending on whether they were above or below TM. Phosphatidylcholines 28-30 twinkle mtDNA helicase Homo sapiens 58-61 33132268-3 2020 We have previously reported that phosphatidylcholine (PC), the predominant bile phospholipid, protects hepatocytes from the cytotoxicity of bile salts, whereas cholesterol reverses the cytoprotective effects of PC against bile salts. Phosphatidylcholines 33-52 pyruvate carboxylase Mus musculus 54-56 31835418-1 2019 : Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Phosphatidylcholines 108-127 patatin like phospholipase domain containing 6 Homo sapiens 2-28 31835418-1 2019 : Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Phosphatidylcholines 108-127 patatin like phospholipase domain containing 6 Homo sapiens 30-33 31835418-1 2019 : Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Phosphatidylcholines 129-131 patatin like phospholipase domain containing 6 Homo sapiens 2-28 31835418-1 2019 : Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Phosphatidylcholines 129-131 patatin like phospholipase domain containing 6 Homo sapiens 30-33 31844833-9 2019 Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis. Phosphatidylcholines 21-23 acyl-CoA binding protein 4 Arabidopsis thaliana 39-46 31844833-9 2019 Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis. Phosphatidylcholines 21-23 acyl-CoA binding protein 5 Arabidopsis thaliana 46-53 31844833-9 2019 Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis. Phosphatidylcholines 21-23 acyl-CoA binding protein 4 Arabidopsis thaliana 192-199 31844833-10 2019 Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds. Phosphatidylcholines 13-15 MBOAT (membrane bound O-acyl transferase) family protein Arabidopsis thaliana 105-111 31844833-10 2019 Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds. Phosphatidylcholines 13-15 phospholipase A 2A Arabidopsis thaliana 117-139 31844833-10 2019 Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds. Phosphatidylcholines 13-15 phospholipase A 2A Arabidopsis thaliana 141-150 31844833-10 2019 Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds. Phosphatidylcholines 13-15 acyl-CoA-binding protein 6 Arabidopsis thaliana 172-179 31873305-1 2020 ABCB4 is an ATP-binding cassette transporter that extrudes phosphatidylcholine into the bile canaliculi of the liver. Phosphatidylcholines 59-78 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 31836711-1 2019 Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare monogenic disease caused by mutations in the ABCB4 gene, resulting in a reduction in biliary phosphatidylcholine. Phosphatidylcholines 164-183 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 116-121 31886153-2 2019 ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane. Phosphatidylcholines 203-222 ATP binding cassette subfamily B member 11 Homo sapiens 0-6 31886153-2 2019 ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane. Phosphatidylcholines 203-222 ATP binding cassette subfamily B member 4 Homo sapiens 149-154 31815960-13 2019 Our study suggests that DENV regulates aminophospholipids, especially phosphatidylcholine and phosphatidylethanolamine, by inhibiting AGPAT1 expression to increase aminophospholipid availability for virus multiplication. Phosphatidylcholines 70-89 1-acylglycerol-3-phosphate O-acyltransferase 1 Homo sapiens 134-140 31726375-4 2019 Using this structural data, computational docking simulation predicted the putative binding sites for phosphatidylcholine (PC), an endogenous ligand that interacts with FT to modulate flowering time. Phosphatidylcholines 102-121 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 169-171 31578786-8 2019 The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC. Phosphatidylcholines 153-155 C-X-C motif chemokine ligand 8 Homo sapiens 44-62 31578786-8 2019 The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC. Phosphatidylcholines 153-155 interleukin 6 Homo sapiens 64-68 31726375-4 2019 Using this structural data, computational docking simulation predicted the putative binding sites for phosphatidylcholine (PC), an endogenous ligand that interacts with FT to modulate flowering time. Phosphatidylcholines 123-125 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 169-171 31665653-8 2019 Brain-derived neurotrophic factor was increased by di-DHA PC and DHA-LPC, but not by TAG-DHA, showing that enrichment of brain DHA correlated with its functional effect. Phosphatidylcholines 58-60 brain-derived neurotrophic factor Rattus norvegicus 0-33 31717561-6 2019 In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects. Phosphatidylcholines 105-124 apolipoprotein E Homo sapiens 185-189 31726375-6 2019 In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function. Phosphatidylcholines 121-123 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 29-31 31726375-6 2019 In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function. Phosphatidylcholines 121-123 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 64-66 31726375-6 2019 In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function. Phosphatidylcholines 121-123 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 64-66 31726375-7 2019 Our structural, biochemical, and transgenic analyses reveal the molecular mechanism of PC binding in FT-mediated flowering time control. Phosphatidylcholines 87-89 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 101-103 31717561-6 2019 In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects. Phosphatidylcholines 126-128 apolipoprotein E Homo sapiens 185-189 31681760-6 2019 In particular, NSM2 ablation resulted in increase of lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) which both govern PM biophysical properties. Phosphatidylcholines 58-77 sphingomyelin phosphodiesterase 3 Homo sapiens 15-19 31376475-6 2019 BMDMs from ACSL4-deficient mice also showed a reduced incorporation of HUFA into phosphatidylcholines. Phosphatidylcholines 81-101 acyl-CoA synthetase long-chain family member 4 Mus musculus 11-16 31439667-10 2019 Overexpression of the AtCCT1 catalytic domain in Nicotiana benthamiana leaves increased PC content, and SnRK1 co-expression reduced this effect. Phosphatidylcholines 88-90 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 22-28 31176036-7 2019 We also showed that the PC efflux from ABCB4-expressing HEK293 cells was stimulated by taurohyodeoxycholate much more strongly than the other tested bile salts. Phosphatidylcholines 24-26 ATP binding cassette subfamily B member 4 Homo sapiens 39-44 31667320-2 2019 In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC). Phosphatidylcholines 135-167 tumor necrosis factor Homo sapiens 44-71 31667320-2 2019 In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC). Phosphatidylcholines 135-167 tumor necrosis factor Homo sapiens 73-81 31667320-2 2019 In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC). Phosphatidylcholines 169-171 tumor necrosis factor Homo sapiens 44-71 31667320-2 2019 In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC). Phosphatidylcholines 169-171 tumor necrosis factor Homo sapiens 73-81 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 141-160 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 126-131 31176036-10 2019 Therefore, the enhancing effect of taurohyodeoxycholate on the ABCB4-mediated PC efflux may be due to the strong mixed micelle formation ability. Phosphatidylcholines 78-80 ATP binding cassette subfamily B member 4 Homo sapiens 63-68 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 141-160 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 179-184 31284753-1 2019 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-49 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 141-160 ATP binding cassette subfamily B member 4 Homo sapiens 234-239 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 162-164 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 126-131 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 162-164 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 179-184 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 162-164 ATP binding cassette subfamily B member 4 Homo sapiens 234-239 31284753-1 2019 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 51-55 31284753-1 2019 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 0-49 31284753-1 2019 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 51-55 31233884-2 2019 Loss of SWS in Drosophila also causes locomotion deficits, age-dependent neurodegeneration, and an increase in lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Phosphatidylcholines 115-134 swiss cheese Drosophila melanogaster 8-11 31199045-0 2019 Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression. Phosphatidylcholines 12-31 glycine N-methyltransferase Homo sapiens 90-117 31199045-2 2019 Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear. Phosphatidylcholines 106-108 phosphatidylethanolamine N-methyltransferase Homo sapiens 34-78 31199045-2 2019 Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear. Phosphatidylcholines 106-108 phosphatidylethanolamine N-methyltransferase Homo sapiens 80-84 31199045-2 2019 Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear. Phosphatidylcholines 176-178 phosphatidylethanolamine N-methyltransferase Homo sapiens 34-78 31199045-2 2019 Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear. Phosphatidylcholines 176-178 phosphatidylethanolamine N-methyltransferase Homo sapiens 80-84 31233884-2 2019 Loss of SWS in Drosophila also causes locomotion deficits, age-dependent neurodegeneration, and an increase in lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Phosphatidylcholines 137-139 swiss cheese Drosophila melanogaster 8-11 31538486-3 2019 ABCB4 encodes for a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 107-126 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 31515451-6 2019 Unbiased atomistic MD simulations with 1.4 mol% PI(4,5)P2 in a phosphatidylcholine bilayer identified 8 binding sites with significant probability of binding PI(4,5)P2 Three of these sites captured 85% of all ANO1-PI(4,5)P2 interactions. Phosphatidylcholines 63-82 anoctamin 1 Homo sapiens 209-213 31608287-8 2019 Furthermore, the DQ alpha-1, DQ beta-1 and p24 transmembrane helical domains were reconstituted into POPC or POPC/SM-C18 lipid bilayers where the fatty acyl chain of either the phosphatidylcholine or of the sphingolipid have been deuterated. Phosphatidylcholines 177-196 transmembrane p24 trafficking protein 2 Homo sapiens 43-46 30730833-3 2019 Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 70-89 ATP binding cassette subfamily B member 4 Homo sapiens 26-31 30730833-3 2019 Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 91-93 ATP binding cassette subfamily B member 4 Homo sapiens 26-31 30730833-4 2019 ABCB4 deficiency can result in altered PC to bile salt ratios, which led to intrahepatic cholestasis of pregnancy, low phospholipid associated cholelithiasis, drug induced liver injury or even progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 39-41 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 31488158-2 2019 We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio. Phosphatidylcholines 27-29 apolipoprotein B Homo sapiens 255-260 31616255-10 2019 In the retina, ELOVL4 is expressed exclusively in photoreceptors and produces VLC-PUFA that are incorporated into phosphatidylcholine and enriched in the light sensitive membrane disks of the photoreceptor outer segments. Phosphatidylcholines 114-133 ELOVL fatty acid elongase 4 Homo sapiens 15-21 31616255-10 2019 In the retina, ELOVL4 is expressed exclusively in photoreceptors and produces VLC-PUFA that are incorporated into phosphatidylcholine and enriched in the light sensitive membrane disks of the photoreceptor outer segments. Phosphatidylcholines 114-133 pumilio RNA binding family member 3 Homo sapiens 82-86 31488158-2 2019 We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio. Phosphatidylcholines 27-29 apolipoprotein B Homo sapiens 265-270 31488158-0 2019 Phosphatidylcholine and its relation to apolipoproteins A-1 and B changes after Roux-en-Y gastric bypass: a cohort study. Phosphatidylcholines 0-19 apolipoprotein A1 Homo sapiens 40-65 31488158-2 2019 We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio. Phosphatidylcholines 27-29 apolipoprotein A1 Homo sapiens 271-277 31488158-2 2019 We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio. Phosphatidylcholines 27-29 apolipoprotein A1 Homo sapiens 247-253 31565053-8 2019 Lower inflammatory cell infiltration in the ileum improved intestinal histology, and reduced serum DAO levels were observed in PC-treated cirrhotic rats. Phosphatidylcholines 127-129 amine oxidase, copper containing 1 Rattus norvegicus 99-102 31303424-5 2019 Growth factor receptor-driven cancers are found to depend on LPCAT1 to shape plasma membrane composition through enhanced saturated phosphatidylcholine content that is, in turn, required for the transduction of oncogenic signals. Phosphatidylcholines 132-151 lysophosphatidylcholine acyltransferase 1 Homo sapiens 61-67 31480447-4 2019 Sphingomyelin synthase (SMS) is the enzyme that transfers a phosphatidylcholine to ceramide to generate sphingomyelin. Phosphatidylcholines 60-79 spermine synthase Homo sapiens 0-22 31062097-6 2019 Regarding the associations between the metabolites and z-BMI, phospholipids, especially those containing polyunsaturated fatty acids, were the species most impacted by the maternal metabolic status, since numerous phosphatidylcholines-PUFA were positively associated with z-BMI in NW but negatively in OV/OB and GDM groups at birth. Phosphatidylcholines 214-234 pumilio RNA binding family member 3 Homo sapiens 235-239 31301838-15 2019 Overall, enhanced supply of choline during NEB increases hepatic activity of BHMT and MTR to regenerate methionine and PC, partly to help clear TAG. Phosphatidylcholines 119-121 betaine--homocysteine S-methyltransferase Bos taurus 77-81 31480447-4 2019 Sphingomyelin synthase (SMS) is the enzyme that transfers a phosphatidylcholine to ceramide to generate sphingomyelin. Phosphatidylcholines 60-79 spermine synthase Homo sapiens 24-27 31380624-0 2019 Impact of Cardiolipin and Phosphatidylcholine Interactions on the Conformational Ensemble of Cytochrome c. Phosphatidylcholines 26-45 cytochrome c, somatic Homo sapiens 93-105 29527950-7 2019 Therefore, incorporation of BdE into phosphatidylcholine-cholesterol liposomes improves its anti-inflammatory effect. Phosphatidylcholines 37-56 homeobox D13 Homo sapiens 28-31 31380624-2 2019 In this work, we study the conformational dynamics of Cyt c in the presence of CL and phosphatidylcholine (PC) phospholipids also present in the mitochondrial membrane to better understand how these interactions might drive transformation to the peroxidase-active protein. Phosphatidylcholines 86-105 cytochrome c, somatic Homo sapiens 54-59 31380624-2 2019 In this work, we study the conformational dynamics of Cyt c in the presence of CL and phosphatidylcholine (PC) phospholipids also present in the mitochondrial membrane to better understand how these interactions might drive transformation to the peroxidase-active protein. Phosphatidylcholines 107-109 cytochrome c, somatic Homo sapiens 54-59 31418690-4 2019 Macrophage-specific knockout of phosphocholine cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway, alleviated obesity-induced WAT inflammation and insulin resistance. Phosphatidylcholines 118-120 phosphate cytidylyltransferase 1A, choline Homo sapiens 71-79 31434800-6 2019 We conclude that human PNPLA3-I148M is a loss-of-function allele that remodels liver TGs in a polyunsaturated direction by impairing hydrolysis/transacylation of PUFAs from DAGs to feed phosphatidylcholine synthesis. Phosphatidylcholines 186-205 patatin like phospholipase domain containing 3 Homo sapiens 23-29 31450691-3 2019 Multilamellar liposomes made of natural phosphatidylcholine were used for the incorporation of a mixture of somatostatin and sorbitol dissolved in citrate buffer at pH = 5. Phosphatidylcholines 40-59 somatostatin Homo sapiens 108-120 31221730-4 2019 Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1. Phosphatidylcholines 51-70 MBOAT (membrane bound O-acyl transferase) family protein Arabidopsis thaliana 82-122 30653260-1 2019 Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). Phosphatidylcholines 110-129 lipase G, endothelial type Homo sapiens 0-18 30653260-1 2019 Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). Phosphatidylcholines 110-129 lipase G, endothelial type Homo sapiens 20-24 31216357-3 2019 The disease is caused by loss of function mutations in the choline kinase beta (CHKB) gene which results in dysfunction of the Kennedy pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 164-183 choline kinase beta Mus musculus 59-78 31216357-3 2019 The disease is caused by loss of function mutations in the choline kinase beta (CHKB) gene which results in dysfunction of the Kennedy pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 164-183 choline kinase beta Mus musculus 80-84 31273804-1 2019 Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 63-79 31273804-1 2019 Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells. Phosphatidylcholines 29-35 phospholipase A2 group IB Homo sapiens 63-79 31221730-4 2019 Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1. Phosphatidylcholines 51-70 phosphatidic acid phosphatase-related / PAP2-like protein Arabidopsis thaliana 128-156 31221730-4 2019 Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1. Phosphatidylcholines 51-70 phospholipid:diacylglycerol acyltransferase Arabidopsis thaliana 231-236 31311871-6 2019 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines 245-264 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 166-169 31311871-6 2019 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines 245-264 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 222-225 31379987-0 2019 Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity in Caenorhabditis elegans. Phosphatidylcholines 0-19 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 41-47 31379987-9 2019 Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine. Phosphatidylcholines 151-170 Heat shock protein hsp-16.2;SHSP domain-containing protein Caenorhabditis elegans 71-79 31379987-9 2019 Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine. Phosphatidylcholines 151-170 Superoxide dismutase [Mn] 2, mitochondrial Caenorhabditis elegans 84-89 31379987-10 2019 DAF-16, a transcription factor modulating stress response genes, was accumulated in the nucleus by phosphatidylcholine treatment. Phosphatidylcholines 99-118 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 0-6 31379987-13 2019 Experiments with long-lived mutants revealed that the lifespan-extending effect of phosphatidylcholine specifically overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16. Phosphatidylcholines 83-102 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 190-196 30953761-8 2019 The silencing of CCTalpha, the key enzyme in PC synthesis, prevents SFA-mediated NLRP3 activation, demonstrating the essential role of the de novo PC synthesis. Phosphatidylcholines 45-47 t-complex 1 Homo sapiens 17-25 31306056-5 2019 RESULTS: We identified an association with relative phosphatidylcholine 38:3 (%PC 38:3) concentration, which was replicated in the ORCADES (Orkney Complex Disease Study; n=951), with a pooled association across studies of 2.59 (95% CI, 1.3-3.9; P=1.1x10-4) ms PWD per mol% increase. Phosphatidylcholines 52-71 ATPase copper transporting beta Homo sapiens 260-263 31181753-1 2019 Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Phosphatidylcholines 156-176 chromatin assembly factor 1 subunit A Homo sapiens 40-44 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 31181753-1 2019 Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Phosphatidylcholines 178-181 chromatin assembly factor 1 subunit A Homo sapiens 40-44 30220058-8 2019 Through the use of specific inhibitors targeting each of the known physiological pathways of choline, synthesis of phosphatidylcholine from choline was found to be essential in bringing about the changes seen in the choline-supplemented MeCP2-knockdown neurons. Phosphatidylcholines 115-134 methyl CpG binding protein 2 Mus musculus 237-242 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 41-60 protoporphyrinogen oxidase Homo sapiens 145-148 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 41-60 protoporphyrinogen oxidase Homo sapiens 153-156 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 41-60 protoporphyrinogen oxidase Homo sapiens 153-156 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 62-66 protoporphyrinogen oxidase Homo sapiens 145-148 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 62-66 protoporphyrinogen oxidase Homo sapiens 153-156 31117745-2 2019 Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group. Phosphatidylcholines 62-66 protoporphyrinogen oxidase Homo sapiens 153-156 30753691-5 2019 Based on combined analyses of gene expression, JA biosynthesis and glycerolipid remodeling in wild-type Arabidopsis and in the coi1-16 mutant, JA signaling seems important in the determination of the basal levels of phosphatidylcholine, phosphatidic acid (PA), monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol. Phosphatidylcholines 216-235 RNI-like superfamily protein Arabidopsis thaliana 127-134 31249646-4 2019 Analysis of the lipid metabolic profiles at young adult and ten-day-old ages among wild-type N2, glp-1 defective mutant, and double mutant daf-16;glp-1 uncovered significant age-related differences in the total amount of phosphatidylcholines (PC), sphingomyelins (SM), ceramides (Cer), diglycerides (DG), and triglycerides (TG). Phosphatidylcholines 221-241 glp-1/Notch intracellular domain Caenorhabditis elegans 146-151 31086211-3 2019 The aim of the present study was to elucidate the respective importance of Chol and SM as compared to phosphatidylcholine (PC) species in the membrane-related effects of Rh2. Phosphatidylcholines 102-121 Rh associated glycoprotein Homo sapiens 170-173 31086211-3 2019 The aim of the present study was to elucidate the respective importance of Chol and SM as compared to phosphatidylcholine (PC) species in the membrane-related effects of Rh2. Phosphatidylcholines 123-125 Rh associated glycoprotein Homo sapiens 170-173 30222019-2 2019 MDR3 mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile. Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 30932478-6 2019 Results show the distribution of some identified molecular ions of the EGFR inhibitor erlotinib, a phosphatidylcholine lipid, and cholesterol, which were reconstructed in 3D and mapped to the MRI space. Phosphatidylcholines 99-118 epidermal growth factor receptor Mus musculus 71-75 31050338-2 2019 Structural insights into the cPLA2alpha preference for phosphatidylcholine (PC)-enriched membranes have remained elusive. Phosphatidylcholines 55-74 phospholipase A2 group IVA Homo sapiens 29-39 31050338-2 2019 Structural insights into the cPLA2alpha preference for phosphatidylcholine (PC)-enriched membranes have remained elusive. Phosphatidylcholines 76-78 phospholipase A2 group IVA Homo sapiens 29-39 31050338-7 2019 Mutagenesis analyses confirm that Tyr96 and Asn65 function in PC binding selectivity by the C2-domain and in the regulation of cPLA2alpha activity. Phosphatidylcholines 62-64 phospholipase A2 group IVA Homo sapiens 127-137 30790612-2 2019 In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity. Phosphatidylcholines 42-61 insulin Homo sapiens 15-22 30837243-4 2019 Specifically, stroma-derived lysophosphatidylcholines support PDAC cell synthesis of phosphatidylcholines, key components of cell membranes, and also facilitate production of the potent wound-healing mediator lysophosphatidic acid (LPA) by the extracellular enzyme autotaxin, which is overexpressed in PDAC. Phosphatidylcholines 33-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 265-274 31040306-1 2019 Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of hepatocytes. Phosphatidylcholines 104-123 ATP binding cassette subfamily B member 4 Homo sapiens 75-80 30958839-12 2019 Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling. Phosphatidylcholines 45-48 tumor necrosis factor Mus musculus 15-23 30958839-12 2019 Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling. Phosphatidylcholines 45-48 interleukin 1 alpha Mus musculus 27-35 30958839-12 2019 Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling. Phosphatidylcholines 45-48 tumor necrosis factor Mus musculus 188-196 30958839-12 2019 Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling. Phosphatidylcholines 45-48 interleukin 1 alpha Mus musculus 201-209 30639288-3 2019 Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets. Phosphatidylcholines 146-165 pleckstrin and Sec7 domain containing 2 Homo sapiens 44-48 30639288-3 2019 Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets. Phosphatidylcholines 167-171 pleckstrin and Sec7 domain containing 2 Homo sapiens 44-48 31788037-3 2019 To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles. Phosphatidylcholines 47-49 phospholipase A2 group IB Homo sapiens 53-57 31788037-3 2019 To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles. Phosphatidylcholines 139-141 phospholipase A2 group IB Homo sapiens 53-57 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). Phosphatidylcholines 149-151 phospholipase A2 group IB Homo sapiens 164-180 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). Phosphatidylcholines 149-151 phospholipase A2 group IVA Homo sapiens 182-192 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). Phosphatidylcholines 246-248 phospholipase A2 group IB Homo sapiens 164-180 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). Phosphatidylcholines 246-248 phospholipase A2 group IVA Homo sapiens 182-192 31788037-6 2019 Finally, genetic validation for the specificity of the method consisted of the downregulation of two biosynthetic enzymes responsible for the production of PE and PC, choline kinase A (CHKA) and ethanolamine kinase 1 (ETNK1). Phosphatidylcholines 163-165 choline kinase alpha Homo sapiens 185-189 31788037-7 2019 This new UPLC ESI-MS/MS method provides accurate and highly sensitive detection of PE and PC species containing AA and DHA allowing for the specific examination of the substrate utilization of these phospholipids by PLA2 in vitro and in cells. Phosphatidylcholines 90-92 phospholipase A2 group IB Homo sapiens 216-220 30773008-0 2019 Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry. Phosphatidylcholines 25-45 TOR signaling pathway regulator Homo sapiens 105-108 30773008-2 2019 In this work, we developed a novel technique termed in-tip solvent microextraction mass spectrometry for the separation and profiling of phosphatidylcholines and triglycerides within a single LD. Phosphatidylcholines 137-157 TOR signaling pathway regulator Homo sapiens 55-58 30790612-2 2019 In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity. Phosphatidylcholines 42-61 surfactant protein C Rattus norvegicus 63-66 30790612-2 2019 In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity. Phosphatidylcholines 42-61 surfactant protein C Rattus norvegicus 87-90 30266576-7 2019 In addition, the major allele of TM6SF2, a set of phosphatidylcholines and several amino acids are associated with healthy livers in obesity. Phosphatidylcholines 50-70 transmembrane 6 superfamily member 2 Homo sapiens 33-39 30615497-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30615497-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 30615497-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30615497-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 30320913-1 2019 Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 30911014-7 2019 In this work, we demonstrate that EB-3D and EB-3P interfere with phosphatidylcholine biosynthesis via both CDP-choline pathway and choline uptake by the cell. Phosphatidylcholines 65-84 natriuretic peptide A Homo sapiens 107-110 30784133-0 2019 The mechanism of phosphatidylcholine-induced interference of PAP (248-286) aggregation. Phosphatidylcholines 17-36 regenerating family member 3 alpha Homo sapiens 61-64 31231513-2 2019 We previously found that LMS is caused by de novo dominant missense mutations in the PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine. Phosphatidylcholines 194-213 phosphatidylserine synthase 1a Danio rerio 144-148 30462540-6 2019 Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis. Phosphatidylcholines 103-122 phosphate cytidylyltransferase 1B, choline Homo sapiens 66-73 30845751-5 2019 LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2). Phosphatidylcholines 43-62 phospholipase A2 group IB Homo sapiens 90-106 30845751-5 2019 LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2). Phosphatidylcholines 43-62 phospholipase A2 group IB Homo sapiens 108-112 30845751-5 2019 LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2). Phosphatidylcholines 1-3 phospholipase A2 group IB Homo sapiens 90-106 30845751-5 2019 LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2). Phosphatidylcholines 1-3 phospholipase A2 group IB Homo sapiens 108-112 30509129-8 2019 Here, we discuss the cellular functions of phosphatidylcholine flippases and suggest a model for the phenotype of progressive familial intrahepatic cholestasis 1 caused by a defect in ATP8B1.-Shin, H.-W., Takatsu, H. Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine). Phosphatidylcholines 43-62 ATPase, class I, type 8B, member 1 Mus musculus 184-190 30366030-2 2019 Phosphocholine cytidylyltransferase (CCT) is the rate-limiting enzyme responsible for catalyzing the formation of PC. Phosphatidylcholines 114-116 FLVCR heme transporter 2 Rattus norvegicus 37-40 31231513-2 2019 We previously found that LMS is caused by de novo dominant missense mutations in the PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine. Phosphatidylcholines 194-213 phosphatidylserine synthase 1a Danio rerio 86-92 31231513-2 2019 We previously found that LMS is caused by de novo dominant missense mutations in the PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine. Phosphatidylcholines 194-213 phosphatidylserine synthase 1a Danio rerio 113-142 30509129-5 2019 By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature. Phosphatidylcholines 50-69 ATPase phospholipid transporting 8B1 Homo sapiens 13-19 30509129-5 2019 By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature. Phosphatidylcholines 50-69 ATPase phospholipid transporting 8B2 Homo sapiens 21-27 30509129-5 2019 By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature. Phosphatidylcholines 50-69 ATPase phospholipid transporting 10A (putative) Homo sapiens 33-39 30509129-5 2019 By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature. Phosphatidylcholines 50-69 ATPase phospholipid transporting 8B1 Homo sapiens 157-163 30462540-6 2019 Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis. Phosphatidylcholines 124-126 phosphate cytidylyltransferase 1B, choline Homo sapiens 66-73 30462540-6 2019 Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis. Phosphatidylcholines 176-178 phosphate cytidylyltransferase 1B, choline Homo sapiens 66-73 30462540-6 2019 Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis. Phosphatidylcholines 176-178 phosphate cytidylyltransferase 1B, choline Homo sapiens 66-73 30820432-0 2019 The Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2. Phosphatidylcholines 51-70 mucin 2, oligomeric mucus/gel-forming Homo sapiens 82-89 30289748-0 2019 Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease. Phosphatidylcholines 8-27 apolipoprotein E Homo sapiens 46-51 30289748-9 2019 Dietary sources of DHA in phospholipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk of AD.-Patrick, R. P. Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease. Phosphatidylcholines 163-182 apolipoprotein E Homo sapiens 201-206 30820432-5 2019 Results: Choline-containing phospholipids, in particular PC, bind to mucin 2 as main scaffold protein of intestinal mucus to establish a hydrophobic barrier towards microbiota in the intestinal lumen. Phosphatidylcholines 57-59 mucin 2, oligomeric mucus/gel-forming Homo sapiens 69-76 30580923-1 2019 Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an appropriate and essential lipid signaling environment for membrane trafficking from trans-Golgi membranes. Phosphatidylcholines 23-42 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 30559292-0 2019 Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTalpha impair enzymatic activity and fold stability. Phosphatidylcholines 32-51 phosphate cytidylyltransferase 1A, choline Homo sapiens 70-78 30559292-3 2019 Previous analyses showed that for some disease-linked PCYT1A variants steady state levels of CCTalpha and PC synthesis were reduced in patient fibroblasts, but other variants impaired PC synthesis with little effect on CCT levels. Phosphatidylcholines 54-56 phosphate cytidylyltransferase 1A, choline Homo sapiens 93-101 30559292-3 2019 Previous analyses showed that for some disease-linked PCYT1A variants steady state levels of CCTalpha and PC synthesis were reduced in patient fibroblasts, but other variants impaired PC synthesis with little effect on CCT levels. Phosphatidylcholines 106-108 phosphate cytidylyltransferase 1A, choline Homo sapiens 54-60 30518673-7 2019 The pmt1 pmt2 double mutant enhanced the defects in root growth, cell viability, and PC content of pmt1, suggesting that PMT2 functions together with PMT1 in roots. Phosphatidylcholines 85-87 polyol/monosaccharide transporter 2 Arabidopsis thaliana 9-13 30518673-7 2019 The pmt1 pmt2 double mutant enhanced the defects in root growth, cell viability, and PC content of pmt1, suggesting that PMT2 functions together with PMT1 in roots. Phosphatidylcholines 85-87 polyol/monosaccharide transporter 2 Arabidopsis thaliana 121-125 30518673-9 2019 In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis. Phosphatidylcholines 110-112 polyol/monosaccharide transporter 2 Arabidopsis thaliana 16-20 30518673-9 2019 In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis. Phosphatidylcholines 110-112 polyol/monosaccharide transporter 1 Arabidopsis thaliana 52-61 30518673-9 2019 In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis. Phosphatidylcholines 148-150 polyol/monosaccharide transporter 2 Arabidopsis thaliana 16-20 30692541-4 2019 Oleic acid with or without tunicamycin significantly increases the formation of nucleoplasmic LDs, to which CDP-choline diacylglycerol phosphotransferase alpha (CCTalpha) is recruited, resulting in activation of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 212-231 phosphate cytidylyltransferase 1A, choline Homo sapiens 161-169 30692541-4 2019 Oleic acid with or without tunicamycin significantly increases the formation of nucleoplasmic LDs, to which CDP-choline diacylglycerol phosphotransferase alpha (CCTalpha) is recruited, resulting in activation of phosphatidylcholine (PC) synthesis. Phosphatidylcholines 233-235 phosphate cytidylyltransferase 1A, choline Homo sapiens 161-169 30629659-2 2019 During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 78-84 choline kinase alpha Homo sapiens 114-118 30629659-2 2019 During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 78-84 choline kinase alpha Homo sapiens 128-153 30629659-2 2019 During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 78-84 phosphate cytidylyltransferase 1A, choline Homo sapiens 166-172 30629659-2 2019 During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 78-84 phosphate cytidylyltransferase 1A, choline Homo sapiens 182-233 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30580923-1 2019 Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an appropriate and essential lipid signaling environment for membrane trafficking from trans-Golgi membranes. Phosphatidylcholines 44-46 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 0-5 30580923-8 2019 Finally, wild-type Sec14, but not a mixture of Sec14 proteins specifically deficient in either PC- or PI-binding activity, was able to effect a net transfer of PI or PC down opposing concentration gradients in vitro. Phosphatidylcholines 95-97 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 19-24 30243987-2 2019 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines 95-114 sphingomyelin synthase 1 Mus musculus 19-32 30610190-4 2019 The crystal structure of a representative TCR bound to CD1b-phosphatidylcholine provides a molecular mechanism for this promiscuous recognition. Phosphatidylcholines 60-79 CD1b molecule Homo sapiens 55-59 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Phosphatidylcholines 94-113 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Phosphatidylcholines 94-113 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Phosphatidylcholines 115-117 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Phosphatidylcholines 115-117 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 159-178 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 159-178 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 180-182 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 180-182 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Phosphatidylcholines 75-94 StAR related lipid transfer domain containing 10 Homo sapiens 0-38 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Phosphatidylcholines 75-94 StAR related lipid transfer domain containing 10 Homo sapiens 40-47 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Phosphatidylcholines 96-98 StAR related lipid transfer domain containing 10 Homo sapiens 0-38 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Phosphatidylcholines 96-98 StAR related lipid transfer domain containing 10 Homo sapiens 40-47 30766963-2 2019 PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 44-63 phosphatidylethanolamine N-methyltransferase Mus musculus 0-4 30766963-2 2019 PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 65-67 phosphatidylethanolamine N-methyltransferase Mus musculus 0-4 30766963-6 2019 We hypothesized that PEMT is an important supplier of PC to the canaliculus and that PEMT activity is critical for the maintenance of canalicular membrane integrity and bile formation following HFD feeding when there is an increase in overall hepatic PC demand. Phosphatidylcholines 54-56 phosphatidylethanolamine N-methyltransferase Mus musculus 21-25 30243987-2 2019 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines 95-114 sphingomyelin synthase 1 Mus musculus 34-38 30243987-2 2019 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines 95-114 beta-site APP cleaving enzyme 1 Mus musculus 198-229 30243987-2 2019 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines 95-114 beta-site APP cleaving enzyme 1 Mus musculus 231-236 30243987-2 2019 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines 95-114 amyloid beta (A4) precursor protein Mus musculus 279-284 30455469-4 2019 Genetic and in vitro characterization of the PLD from Escherichia coli MS 200-1 showed this enzyme is essential for bacterial hydrolysis of PC and prefers this substrate. Phosphatidylcholines 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 30587782-2 2018 PLDalpha1 has a substrate preference for phosphatidylcholine leading to enzymatic production of phosphatidic acid, a lipid second messenger with multiple cellular functions. Phosphatidylcholines 41-60 phospholipase D alpha 1 Arabidopsis thaliana 0-9 30159756-6 2018 Pretreatment with S117A-FGF2 protected against Dox-induced: oxidative stress; upregulation of fragmented and non-fragmented oxidized phosphatidylcholine species, measured by LC/MS/MS; and cardiomyocyte injury and cell death measured by LDH release and a live-dead assay. Phosphatidylcholines 133-152 fibroblast growth factor 2 Homo sapiens 24-28 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 21-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 21-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30103144-1 2018 Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30103144-1 2018 Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30577564-1 2018 This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property. Phosphatidylcholines 27-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 182-198 30577564-1 2018 This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property. Phosphatidylcholines 48-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 182-198 30315445-1 2018 StarD7 is a lipid binding protein involved in the delivery of phosphatidylcholine to the mitochondria whose promoter is activated by Wnt/beta-catenin signaling. Phosphatidylcholines 62-81 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 30054282-0 2018 [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Phosphatidylcholines 78-97 TSC complex subunit 1 Homo sapiens 152-155 30054282-6 2018 RESULTS: We previously reported that TSC2-deficient cells enhance phosphatidylcholine synthesis via the Kennedy pathway. Phosphatidylcholines 66-85 TSC complex subunit 2 Homo sapiens 37-41 30315445-1 2018 StarD7 is a lipid binding protein involved in the delivery of phosphatidylcholine to the mitochondria whose promoter is activated by Wnt/beta-catenin signaling. Phosphatidylcholines 62-81 catenin beta 1 Homo sapiens 137-149 30218542-4 2018 Here, we show that PMT1 and PMT3 redundantly play an essential role in phosphocholine (PCho) biosynthesis, a prerequisite for PtdCho production. Phosphatidylcholines 126-132 polyol/monosaccharide transporter 1 Arabidopsis thaliana 19-23 30218542-5 2018 A pmt1 pmt3 double mutant was devoid of PCho, which affected PtdCho biosynthesis in vivo, showing severe growth defects in post-embryonic development. Phosphatidylcholines 61-67 polyol/monosaccharide transporter 1 Arabidopsis thaliana 2-6 30218542-8 2018 We suggest that PMT1 and PMT3 are the primary enzymes for PCho biosynthesis and are involved in PtdCho biosynthesis and vascular development in Arabidopsis seedlings. Phosphatidylcholines 96-102 polyol/monosaccharide transporter 1 Arabidopsis thaliana 16-20 30305392-9 2018 The treatment inhibited lysophosphatidylcholine acyltransferase (LPCAT) activity, consistent with the aforementioned reduction in plasma phosphatidylcholine. Phosphatidylcholines 28-47 lysophosphatidylcholine acyltransferase 1 Homo sapiens 65-70 30477200-7 2018 Reducing the ratio of PC to PE increased the binding of perilipin 2 to liposomes in an in vitro experiment. Phosphatidylcholines 22-24 perilipin 2 Rattus norvegicus 56-67 30343580-3 2018 A KAT derivative of oleic acid (OA-KAT, 1) was added to a mixture of three lipid components (triolein, phosphatidyl choline, and cholesteryl oleate), which have been commonly used as substrates for lipid nanoparticles. Phosphatidylcholines 103-123 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 2-5 30281048-0 2018 Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition. Phosphatidylcholines 0-19 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 54-63 30281048-0 2018 Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition. Phosphatidylcholines 0-19 protein C receptor Homo sapiens 74-78 30281048-0 2018 Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition. Phosphatidylcholines 0-19 protein C receptor Homo sapiens 90-94 30281048-0 2018 Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition. Phosphatidylcholines 0-19 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 112-121 30281048-5 2018 Molecular dynamics simulations along with potential of mean force (PMF) calculations were carried out in order to provide molecular insight into the dynamics and free energies of EPCR-PC in the absence/presence of phospholipid, namely lysophosphatidylcholine (lysoPCh) and phosphatidylcholine (PCh) in the antigen-binding groove of the EPCR. Phosphatidylcholines 239-258 protein C receptor Homo sapiens 179-183 30281048-8 2018 With regards to the two hydrophobic tails of PCh, one lipid tail regulates EPCR conformation while the other promotes ligand recognition by interacting with the keel residue (Phe-4) of PC. Phosphatidylcholines 45-48 protein C receptor Homo sapiens 75-79 30281048-10 2018 Our studies for the first time explore the possible mode of ligand recognition by the EPCR via the involvement of phosphatidylcholine within its hydrophobic groove. Phosphatidylcholines 114-133 protein C receptor Homo sapiens 86-90 30359036-0 2018 Nonclassical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study. Phosphatidylcholines 29-48 LOC100508689 Homo sapiens 54-59 30359036-9 2018 The fact that phosphatidylcholine sustains the binding capability to enzymatically degraded mucin suggests that the direct delivery of phosphatidylcholine to the damaged mucus is a promising strategy for the better treatment of patients affected by inflammatory bowel diseases. Phosphatidylcholines 14-33 LOC100508689 Homo sapiens 92-97 30359036-9 2018 The fact that phosphatidylcholine sustains the binding capability to enzymatically degraded mucin suggests that the direct delivery of phosphatidylcholine to the damaged mucus is a promising strategy for the better treatment of patients affected by inflammatory bowel diseases. Phosphatidylcholines 135-154 LOC100508689 Homo sapiens 92-97 30360613-7 2018 The interaction with a planar lipid bilayer composed of phosphatidylcholine and cholesterol with myristoylated and nonmyristoylated recoverin is studied by in situ polarization modulation infrared reflection absorption spectroscopy. Phosphatidylcholines 56-75 recoverin Homo sapiens 132-141 30226041-2 2018 One pathway for the biosynthesis of the abundant lipid phosphatidylcholine in eukaryotes involves a membrane-integrated phospholipid methyltransferase named Opi3 in yeast. Phosphatidylcholines 55-74 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 157-161 30357767-1 2018 ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 0-41 30357767-1 2018 ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 43-48 30830399-8 2018 Phosphatidylcholines, lyso-phosphatidylcholines and fatty acids were significantly changed among pathological samples suggesting changes in phospholipase A2 and arachidonic acid metabolic pathways. Phosphatidylcholines 0-20 phospholipase A2 group IB Homo sapiens 140-156 29935094-3 2018 Soya lecithin origin phosphatidylcholine (soya PC) was identified as a natural TLR4 antagonist by computational study. Phosphatidylcholines 21-40 toll-like receptor 4 Rattus norvegicus 79-83 30226041-3 2018 A still unanswered question is whether Opi3 can catalyze phosphatidylcholine synthesis in trans, at membrane contact sites. Phosphatidylcholines 57-76 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 39-43 30226041-9 2018 Phosphatidylcholine formation was observed not only in nanodiscs containing inserted Opi3 but also in nanodiscs devoid of the enzyme containing the lipid substrate. Phosphatidylcholines 0-19 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 85-89 30199242-5 2018 In this work, we report on the observation that phosphatidylcholines form abundant doubly charged metal ion complexes during electrospray ionization (ESI) and show that these complexes can be used to assign fatty acid moieties, relatively quantify sn-isomers in MS2 experiments, and mass spectrometrically separate phosphatidylcholines from other phospholipid classes in positive ion mode. Phosphatidylcholines 48-68 MS2 Homo sapiens 262-265 30115754-4 2018 CRISPR/Cas9 knockout of CCTalpha in Caco2 cells (Caco2-KO cells) reduced PC synthesis by 50%. Phosphatidylcholines 73-75 phosphate cytidylyltransferase 1A, choline Homo sapiens 24-32 29894783-4 2018 The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS). Phosphatidylcholines 87-106 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 29894783-4 2018 The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS). Phosphatidylcholines 108-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 30284996-7 2018 After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Phosphatidylcholines 194-213 lactotransferrin Rattus norvegicus 33-35 30115754-9 2018 Thus, reduced de novo PC synthesis in Caco2 cells enhances TG storage in large LDs and inhibits apoB48 chylomicron secretion. Phosphatidylcholines 22-24 apolipoprotein B Homo sapiens 96-102 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 0-26 30281112-1 2018 Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 101-120 phosphatidylethanolamine N-methyltransferase Mus musculus 12-56 30281112-1 2018 Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 101-120 phosphatidylethanolamine N-methyltransferase Mus musculus 58-62 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 28-33 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 108-113 30228369-4 2018 Acot7 overexpression modified specific phosphatidylcholine and phosphatidylethanolamine species in tibialis muscle of chow rats to levels similar to those observed in control HFD muscle. Phosphatidylcholines 39-58 acyl-CoA thioesterase 7 Rattus norvegicus 0-5 32254972-3 2018 Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional beta-galactosidase. Phosphatidylcholines 88-107 galactosidase beta 1 Homo sapiens 157-175 29774420-1 2018 PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property. Phosphatidylcholines 13-32 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 108-117 29774420-1 2018 PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property. Phosphatidylcholines 13-32 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 119-122 29774420-1 2018 PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property. Phosphatidylcholines 35-37 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 108-117 29774420-1 2018 PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property. Phosphatidylcholines 35-37 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 119-122 30059845-10 2018 Human and Ldlr-/- mice shared 11 significant metabolites displaying the same direction of regulation: 5 phosphatidylcholines, 1 lysophosphatidylcholines, 5 sphingomyelins; ApoE-/- mice shared 10. Phosphatidylcholines 104-124 low density lipoprotein receptor Homo sapiens 10-14 29895698-0 2018 Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice. Phosphatidylcholines 68-87 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 42-47 29691610-2 2018 We have investigated the interaction of recoverin with zwitterionic phosphatidylcholine bilayers, the major lipid component of the rod outer segment disk membranes, using both 31P and 19F solid-state nuclear magnetic resonance (NMR) and infrared spectroscopy. Phosphatidylcholines 68-87 recoverin Homo sapiens 40-49 29691610-8 2018 19F NMR results allow the observation of the calcium-myristoyl switch, the myristoyl group experiencing two different environments in the absence of Ca2+ and the immobilization of the recoverin myristoyl moiety in phosphatidylcholine membranes in the presence of Ca2+. Phosphatidylcholines 214-233 recoverin Homo sapiens 184-193 29895698-1 2018 The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Phosphatidylcholines 72-91 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 37-42 29895698-1 2018 The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Phosphatidylcholines 72-91 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 43-47 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 8-27 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 47-92 29895698-1 2018 The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Phosphatidylcholines 93-95 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 37-42 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 8-27 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 94-101 29895698-1 2018 The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Phosphatidylcholines 93-95 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 43-47 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 8-27 CD320 antigen Mus musculus 119-123 29895698-8 2018 Thus, T3-via THRbeta1 as a novel transcriptional activator regulates ABCB4 to increase ABCB4 protein levels at the canalicular membrane and promote PC secretion into bile. Phosphatidylcholines 148-150 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 69-74 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 29-31 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 47-92 30148882-3 2018 Here we demonstrate that the cellular enzyme CCTalpha, responsible for the rate-limiting step in phosphatidylcholine synthesis, translocates from the nuclei to the cytoplasm upon infection and associates with the replication membranes, resulting in the rerouting of lipid synthesis from predominantly neutral lipids to phospholipids. Phosphatidylcholines 97-116 phosphate cytidylyltransferase 1A, choline Homo sapiens 45-53 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 29-31 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 94-101 30007917-1 2018 De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion. Phosphatidylcholines 29-31 CD320 antigen Mus musculus 119-123 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 111-130 heparan sulfate proteoglycan 2 Homo sapiens 35-38 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 111-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 132-134 heparan sulfate proteoglycan 2 Homo sapiens 35-38 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidylcholines 19-21 heparan sulfate proteoglycan 2 Homo sapiens 6-9 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidylcholines 66-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 30159399-6 2018 We observed that PC liposomes completely disintegrate in the presence of PLC, as conversion of PC to DAG progresses. Phosphatidylcholines 17-19 heparan sulfate proteoglycan 2 Homo sapiens 73-76 30159399-11 2018 Conversely, PLD-treated PC liposomes remain stable up to extremely high conversions to PA. Phosphatidylcholines 24-26 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 12-15 30169917-4 2018 We identified lipids in plasma from 44 healthy subjects that correlated with CES1 activity as determined by PK parameters of methylphenidate including a ceramide (q value = 0.001) and a phosphatidylcholine (q value = 0.005). Phosphatidylcholines 186-205 carboxylesterase 1 Homo sapiens 77-81 29866392-6 2018 RESULTS: Lpcat3-deficient macrophages displayed major reductions in the arachidonate content of phosphatidylcholines, phosphatidylethanolamines and, unexpectedly, plasmalogens. Phosphatidylcholines 96-116 lysophosphatidylcholine acyltransferase 3 Mus musculus 9-15 29906468-7 2018 Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice. Phosphatidylcholines 37-57 ferrochelatase Mus musculus 140-144 29906468-7 2018 Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice. Phosphatidylcholines 59-61 ferrochelatase Mus musculus 140-144 29906468-7 2018 Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice. Phosphatidylcholines 99-101 ferrochelatase Mus musculus 140-144 30169917-5 2018 Carriers of the CES1 143E allele had decreased methylphenidate metabolism and altered concentration of this phosphatidylcholine (q value = 0.040) and several high polyunsaturated fatty acid lipids (PUFAs). Phosphatidylcholines 108-127 carboxylesterase 1 Homo sapiens 16-20 29691802-9 2018 The dissociation constants for binding to PS/phosphatidylcholine (PC) liposomes of N-terminally acetylated (NAc) alpha-syn was lower than that of non NAc alpha-syn. Phosphatidylcholines 45-64 synuclein alpha Homo sapiens 113-122 29345004-1 2018 Sphingomyelin synthase (SMS) is an enzyme that generates sphingomyelin (SM) from ceramide (CER) and phosphatidylcholine. Phosphatidylcholines 100-119 spermine synthase Mus musculus 24-27 29777000-7 2018 Analysis of loss-of-function mutants demonstrates that NMT1 and NMT3 synergistically regulate PC homeostasis, phase transition at the shoot apex, coordinated organ development, and fertility through overlapping but also specific functions. Phosphatidylcholines 94-96 myristoyl-CoA:protein N-myristoyltransferase Arabidopsis thaliana 55-59 29679463-1 2018 Cytidine-5"-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Phosphatidylcholines 95-114 cut-like homeobox 1 Rattus norvegicus 30-33 29853639-0 2018 Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated alpha-synuclein. Phosphatidylcholines 11-30 synuclein alpha Homo sapiens 112-127 30108598-1 2018 Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis. Phosphatidylcholines 126-145 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 21-43 30108598-1 2018 Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis. Phosphatidylcholines 126-145 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 45-49 29853639-2 2018 Most previous studies on alpha-syn-membrane interactions have not used the physiologically relevant N-terminally acetylated (N-acetyl) alpha-syn form nor the most naturally abundant cellular lipid, i.e. phosphatidylcholine (PC). Phosphatidylcholines 224-226 synuclein alpha Homo sapiens 25-34 29635711-6 2018 A smaller group of patients might develop gallstones primarily due low phosphatidylcholine concentrations in bile as a result of loss-of-function mutations of the ABCB4 transporter (low phospholipid-associated cholelithiasis syndrome). Phosphatidylcholines 71-90 ATP binding cassette subfamily B member 4 Homo sapiens 163-168 29660601-4 2018 To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D). Phosphatidylcholines 103-122 cathelicidin antimicrobial peptide Homo sapiens 74-78 28665188-2 2018 Analysis of the changes of lysozyme secondary structure upon its interactions with the model bilayer membranes composed of phosphatidylcholine and its mixtures with phosphatidylglycerol (10, 40, and 80 mol%) within the time interval of 100 ns showed that lipid-bound protein is characterized by the increased content of beta-structures. Phosphatidylcholines 123-142 lysozyme Homo sapiens 27-35 29602217-4 2018 The (FITC-AC)-royalisin P11 bound with high specificity to ox-LDL in a dose-dependent manner, through the binding to major lipid components in ox-LDL (lysophosphatidylcholine and oxidized phosphatidylcholine). Phosphatidylcholines 155-174 defensin-1 Apis mellifera 14-23 29655284-8 2018 In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs. Phosphatidylcholines 59-78 non-specific phospholipase C2 Arabidopsis thaliana 35-39 31249994-3 2018 Sn-2 phosphatidylcholine prodrugs delivered by hemifusion of nanoparticle and cell phospholipid membranes functioned as phosphatidylcholine mimics, circumventing the challenges of endosome sequestration and release. Phosphatidylcholines 5-24 solute carrier family 38 member 5 Homo sapiens 0-4 31249994-8 2018 We have demonstrated that Sn-2 phosphatidylcholine prodrugs function as phosphatidylcholine mimics following reported pathways of phosphatidylcholine distribution and metabolism. Phosphatidylcholines 31-50 solute carrier family 38 member 5 Homo sapiens 26-30 31249994-8 2018 We have demonstrated that Sn-2 phosphatidylcholine prodrugs function as phosphatidylcholine mimics following reported pathways of phosphatidylcholine distribution and metabolism. Phosphatidylcholines 72-91 solute carrier family 38 member 5 Homo sapiens 26-30 29655284-8 2018 In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs. Phosphatidylcholines 59-78 non-specific phospholipase C6 Arabidopsis thaliana 44-48 29716960-2 2018 Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways. Phosphatidylcholines 7-26 phosphatidylethanolamine N-methyltransferase Homo sapiens 201-245 29716960-2 2018 Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways. Phosphatidylcholines 7-26 phosphatidylethanolamine N-methyltransferase Homo sapiens 247-251 29716960-2 2018 Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways. Phosphatidylcholines 28-30 phosphatidylethanolamine N-methyltransferase Homo sapiens 201-245 29716960-2 2018 Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways. Phosphatidylcholines 28-30 phosphatidylethanolamine N-methyltransferase Homo sapiens 247-251 29670126-0 2018 Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation. Phosphatidylcholines 43-62 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 95-100 29519816-1 2018 The activity of CTP:phosphocholine cytidylyltransferase (CCT), a key enzyme in phosphatidylcholine synthesis, is regulated by reversible interactions of a lipid-inducible amphipathic helix (domain M) with membrane phospholipids. Phosphatidylcholines 79-98 solute carrier family 25 member 1 Homo sapiens 16-19 29695812-0 2018 Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Phosphatidylcholines 16-35 insulin Homo sapiens 99-106 29695812-1 2018 Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity. Phosphatidylcholines 0-19 insulin Homo sapiens 110-117 29695812-1 2018 Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity. Phosphatidylcholines 21-23 insulin Homo sapiens 110-117 29728535-1 2018 The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. Phosphatidylcholines 18-37 phosphate cytidylyltransferase 1A, choline Homo sapiens 76-121 29728535-1 2018 The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. Phosphatidylcholines 18-37 phosphate cytidylyltransferase 1A, choline Homo sapiens 123-131 29728535-1 2018 The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. Phosphatidylcholines 39-41 phosphate cytidylyltransferase 1A, choline Homo sapiens 76-121 29728535-1 2018 The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. Phosphatidylcholines 39-41 phosphate cytidylyltransferase 1A, choline Homo sapiens 123-131 29578333-5 2018 The rate of phosphatidylcholine vesicle solubilization was enhanced for all variants, with approximately a threefold rate enhancement for apoA-I lacking Lys 206, 208, 238, and 239, or Glu 234 and 235. Phosphatidylcholines 12-31 apolipoprotein A-I Mus musculus 138-144 29578333-8 2018 However, this protein was more effective in releasing cellular phosphatidylcholine and sphingomyelin from Abca1-null mice macrophage foam cells. Phosphatidylcholines 63-82 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 106-111 29670126-5 2018 In this study, we found that trypsin treatment causes rapid release of phosphatidylcholine (PC) and cholesterol from BHK/ABCA1 cells, and that the time course of lipid release coincides with those of trypsin digestion of extracellular domains (ECDs) of surface ABCA1 and of release of ECD fragments into the medium. Phosphatidylcholines 71-90 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 121-126 29670126-5 2018 In this study, we found that trypsin treatment causes rapid release of phosphatidylcholine (PC) and cholesterol from BHK/ABCA1 cells, and that the time course of lipid release coincides with those of trypsin digestion of extracellular domains (ECDs) of surface ABCA1 and of release of ECD fragments into the medium. Phosphatidylcholines 92-94 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 121-126 29805971-9 2018 The greater efficacy of L-PC seen in NAFLD volunteers may reflect improved bioavailability of PC owing to better protection of the microencapsulated PC from gastrointestinal enzymes and possibly enhanced hepatic delivery of L-PC particles. Phosphatidylcholines 26-28 proprotein convertase subtilisin/kexin type 7 Homo sapiens 224-228 29178478-3 2018 The main pathway for the synthesis of PC is the Kennedy (CDP-choline) pathway. Phosphatidylcholines 38-40 cut like homeobox 1 Homo sapiens 57-60 29178478-4 2018 In this pathway, choline is converted to phosphocholine by choline kinase, phosphocholine is metabolized to CDP-choline by the rate-determining enzyme for this pathway, CTP:phosphocholine cytidylyltransferase, and cholinephosphotransferase condenses CDP-choline with diacylglycerol to produce PC. Phosphatidylcholines 293-295 cut like homeobox 1 Homo sapiens 108-111 29805971-9 2018 The greater efficacy of L-PC seen in NAFLD volunteers may reflect improved bioavailability of PC owing to better protection of the microencapsulated PC from gastrointestinal enzymes and possibly enhanced hepatic delivery of L-PC particles. Phosphatidylcholines 94-96 proprotein convertase subtilisin/kexin type 7 Homo sapiens 24-28 29655691-8 2018 All nanoformulations conserved the antioxidant potential of AE, while phosphatidylcholine interfered with MAO-A inhibition assay. Phosphatidylcholines 70-89 monoamine oxidase A Homo sapiens 106-111 29396267-7 2018 SMAC/Diablo silencing decreased the levels of phospholipids, including phosphatidylcholine. Phosphatidylcholines 71-90 diablo, IAP-binding mitochondrial protein Mus musculus 0-4 29396267-7 2018 SMAC/Diablo silencing decreased the levels of phospholipids, including phosphatidylcholine. Phosphatidylcholines 71-90 diablo, IAP-binding mitochondrial protein Mus musculus 5-11 29437858-7 2018 This work includes several examples of lipid pathways for phosphatidylcholine and phosphatidylethanolamine lipids that help elucidate the molecular mechanism of lipid binding in P-gp. Phosphatidylcholines 58-77 ATP binding cassette subfamily B member 1 Homo sapiens 178-182 29527260-1 2018 Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidylcholine. Phosphatidylcholines 101-120 ectonucleotide pyrophosphatase/phosphodiesterase 7 Homo sapiens 0-25 29132829-0 2018 The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase. Phosphatidylcholines 83-102 phospholipase A2 group IB Homo sapiens 128-144 29132829-0 2018 The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase. Phosphatidylcholines 83-102 lipase C, hepatic type Homo sapiens 149-171 29420298-4 2018 Model simulations perfectly recapitulate the measured dependence of bile salt-dependent biliary lipid extraction rates upon modulation of the membrane cholesterol (lack or overexpression of the cholesterol transporter Abcg5-Abcg8) and phosphatidylcholine (lack of Mdr2, also known as Abcb4) content. Phosphatidylcholines 235-254 ATP binding cassette subfamily G member 5 Homo sapiens 218-223 29420298-4 2018 Model simulations perfectly recapitulate the measured dependence of bile salt-dependent biliary lipid extraction rates upon modulation of the membrane cholesterol (lack or overexpression of the cholesterol transporter Abcg5-Abcg8) and phosphatidylcholine (lack of Mdr2, also known as Abcb4) content. Phosphatidylcholines 235-254 ATP binding cassette subfamily G member 8 Homo sapiens 224-229 29343537-5 2018 Previous work revealed that StarD7 is required for efficient mitochondrial import of phosphatidylcholine (PC) and serves a critical role in mitochondrial function and morphology. Phosphatidylcholines 85-104 StAR related lipid transfer domain containing 7 Homo sapiens 28-34 29343537-5 2018 Previous work revealed that StarD7 is required for efficient mitochondrial import of phosphatidylcholine (PC) and serves a critical role in mitochondrial function and morphology. Phosphatidylcholines 106-108 StAR related lipid transfer domain containing 7 Homo sapiens 28-34 29343537-6 2018 Combining site-directed mutagenesis and photoaffinity labeling experiments, we demonstrate that the steroidogenic acute regulatory transfer domain of StarD7 harbors a common binding site for PC and ceramide. Phosphatidylcholines 191-193 StAR related lipid transfer domain containing 7 Homo sapiens 150-156 29453864-6 2018 Finally, we show that in Zn deficient conditions loss of function of LPCAT1 increases the phospholipid Lyso-PhosphatidylCholine/PhosphatidylCholine ratio, the expression of the Pi transporter PHT1;1, and that this leads to shoot Pi accumulation. Phosphatidylcholines 108-127 lysophosphatidylcholine acyltransferase 1 Homo sapiens 69-75 29301859-3 2018 Here, we identify the START domain-containing protein STARD7 as an intramitochondrial lipid transfer protein for phosphatidylcholine. Phosphatidylcholines 113-132 StAR related lipid transfer domain containing 7 Homo sapiens 54-60 29301859-6 2018 Mitochondrial STARD7 is necessary and sufficient for the accumulation of phosphatidylcholine in the inner membrane and for the maintenance of respiration and cristae morphogenesis. Phosphatidylcholines 73-92 StAR related lipid transfer domain containing 7 Homo sapiens 14-20 29284086-1 2018 Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) membranes, and a mixture of the two. Phosphatidylcholines 308-327 sperm adhesion molecule 1 Homo sapiens 189-193 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 164-167 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 phospholipase D1 Homo sapiens 172-176 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 181-188 29300825-5 2018 NPC2 enzyme activity was determined using fluorescent phosphatidylcholine as a substrate. Phosphatidylcholines 54-73 non-specific phospholipase C2 Arabidopsis thaliana 0-4 29300825-9 2018 Key Results: The heterologously expressed protein possessed phospholipase C activity, being able to hydrolyse phosphatidylcholine to diacylglycerol. Phosphatidylcholines 110-129 phospholipase C1 Arabidopsis thaliana 60-75 29416063-0 2018 AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Phosphatidylcholines 21-40 aryl hydrocarbon receptor Homo sapiens 0-3 29416063-0 2018 AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Phosphatidylcholines 21-40 nuclear receptor subfamily 0 group B member 2 Homo sapiens 8-11 29416063-5 2018 Adenoviral-mediated expression of AhR in obese mice increases PC levels and exacerbates steatosis, effects that are blunted by SHP co-expression or Pemt downregulation. Phosphatidylcholines 62-64 aryl-hydrocarbon receptor Mus musculus 34-37 29416063-7 2018 This study identifies AhR and SHP as new physiological regulators of PC/SAM levels. Phosphatidylcholines 69-71 aryl hydrocarbon receptor Homo sapiens 22-25 29416063-7 2018 This study identifies AhR and SHP as new physiological regulators of PC/SAM levels. Phosphatidylcholines 69-71 nuclear receptor subfamily 0 group B member 2 Homo sapiens 30-33 29284086-1 2018 Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) membranes, and a mixture of the two. Phosphatidylcholines 329-331 sperm adhesion molecule 1 Homo sapiens 189-193 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 151-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 29353041-3 2018 FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma. Phosphatidylcholines 129-148 fatty acid desaturase 2 Mus musculus 0-5 29353041-3 2018 FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma. Phosphatidylcholines 150-152 fatty acid desaturase 2 Mus musculus 0-5 29353041-5 2018 These results supposed that Mead acid in PC is important as a component of VLDL. Phosphatidylcholines 41-43 CD320 antigen Mus musculus 75-79 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 151-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 29569242-10 2018 These results suggest that the inhibitory effect of egg-yolk CerPCho and PtdCho on cholesterol transport might be due to their interference with the physicochemical properties of micelles and their regulations on the expression of the NPC1L1 gene. Phosphatidylcholines 73-79 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 235-241 29290583-3 2018 The basis of the ER-mitochondrial PC synthesis pathway is the exclusive mitochondrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates phosphatidylethanolamine (PE). Phosphatidylcholines 34-36 pleckstrin and Sec7 domain containing Homo sapiens 157-161 29411327-9 2018 CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. Phosphatidylcholines 64-83 phosphate cytidylyltransferase 1A, choline Homo sapiens 119-124 29411327-9 2018 CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. Phosphatidylcholines 64-83 lysophosphatidylcholine acyltransferase 1 Homo sapiens 126-132 29411327-9 2018 CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. Phosphatidylcholines 64-83 choline phosphotransferase 1 Homo sapiens 134-139 29154090-2 2018 The canonical enzymes PLD1 and PLD2 enact their diverse effects through hydrolyzing the membrane lipid phosphatidylcholine to generate the second messenger and signaling lipid phosphatidic acid (PA). Phosphatidylcholines 103-122 phospholipase D1 Mus musculus 22-26 29293603-5 2018 We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs. Phosphatidylcholines 33-52 neural retina leucine zipper gene Mus musculus 142-145 29358673-4 2018 Here we show that LD content of CRC cells positively correlates with the expression of lysophosphatidylcholine acyltransferase 2 (LPCAT2), an LD-localised enzyme supporting phosphatidylcholine synthesis. Phosphatidylcholines 91-110 lysophosphatidylcholine acyltransferase 2 Homo sapiens 130-136 29293603-5 2018 We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs. Phosphatidylcholines 33-52 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 Mus musculus 149-155 29154090-2 2018 The canonical enzymes PLD1 and PLD2 enact their diverse effects through hydrolyzing the membrane lipid phosphatidylcholine to generate the second messenger and signaling lipid phosphatidic acid (PA). Phosphatidylcholines 103-122 phospholipase D2 Mus musculus 31-35 29428958-1 2018 BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Phosphatidylcholines 108-127 patatin like phospholipase domain containing 6 Homo sapiens 17-43 29428958-1 2018 BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Phosphatidylcholines 108-127 patatin like phospholipase domain containing 6 Homo sapiens 45-48 29428958-1 2018 BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Phosphatidylcholines 129-131 patatin like phospholipase domain containing 6 Homo sapiens 17-43 29428958-1 2018 BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Phosphatidylcholines 129-131 patatin like phospholipase domain containing 6 Homo sapiens 45-48 28879486-2 2018 In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios. Phosphatidylcholines 95-114 cytochrome c, somatic Homo sapiens 145-150 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 139-158 phospholipase A2 group IB Homo sapiens 32-48 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 139-158 phospholipase A2 group IB Homo sapiens 50-54 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 139-158 ectonucleotide pyrophosphatase/phosphodiesterase 6 Homo sapiens 60-109 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 139-158 ectonucleotide pyrophosphatase/phosphodiesterase 6 Homo sapiens 111-116 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 139-158 phosphoethanolamine/phosphocholine phosphatase 1 Homo sapiens 214-222 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 369-388 phospholipase A2 group IB Homo sapiens 32-48 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 369-388 phospholipase A2 group IB Homo sapiens 50-54 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 369-388 ectonucleotide pyrophosphatase/phosphodiesterase 6 Homo sapiens 60-109 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 369-388 ectonucleotide pyrophosphatase/phosphodiesterase 6 Homo sapiens 111-116 28864658-4 2018 Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization. Phosphatidylcholines 369-388 phosphoethanolamine/phosphocholine phosphatase 1 Homo sapiens 214-222 28879486-2 2018 In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios. Phosphatidylcholines 286-305 cytochrome c, somatic Homo sapiens 145-150 28879486-2 2018 In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios. Phosphatidylcholines 307-309 cytochrome c, somatic Homo sapiens 145-150 29577851-6 2018 METHODS: Recombinant human alpha-synuclein was expressed and isolated and incubated in the presence of phosphatidylcholine and phosphatidylserine (PC/PS) containing liposomes. Phosphatidylcholines 103-122 synuclein alpha Homo sapiens 27-42 29247563-13 2018 Citicoline increased choline acetyltransferase expression for phosphatidylcholine synthesis after hypoglycaemia. Phosphatidylcholines 62-81 choline O-acetyltransferase Rattus norvegicus 21-46 30109649-3 2018 However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis. Phosphatidylcholines 131-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 30109649-3 2018 However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis. Phosphatidylcholines 152-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 30109649-5 2018 This assay exhibits a strong fluorescence signal upon Ca2+ complexation with the PLD-generated PA and is not limited to PC as the substrate but allows the use of natural phospholipids with various headgroups. Phosphatidylcholines 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 30689326-9 2018 The anti-tuberculosis chemotherapy gives rise to activation of phospholipase A2 that shows membrane destructive effect on mononuclears of peripheral blood and results in disorganization of their membranes manifesting in cumulation of lysophospholipids at simultaneous decreasing of percentage content of phosphatidylserine and phosphatidylcholine. Phosphatidylcholines 327-346 phospholipase A2 group IB Homo sapiens 63-79 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 29186713-0 2018 Phosphatidylcholine Causes Lipolysis and Apoptosis in Adipocytes through the Tumor Necrosis Factor Alpha-Dependent Pathway. Phosphatidylcholines 0-19 tumor necrosis factor Mus musculus 77-104 29186713-10 2018 Through in vivo experiments, we demonstrated that PPC injection not only stimulated the local lipolysis and apoptosis, resulting in weight loss, but also induced TNFalpha mRNA expression and neutrophil infiltration. Phosphatidylcholines 50-53 tumor necrosis factor Mus musculus 162-170 29186713-12 2018 In conclusion, we suggest that PPC induces lipolysis and apoptosis in adipocytes through TNFalpha-dependent pathways. Phosphatidylcholines 31-34 tumor necrosis factor Mus musculus 89-97 29030428-1 2017 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high-density lipoproteins (HDL) from discoidal to spherical particles. Phosphatidylcholines 129-148 lecithin-cholesterol acyltransferase Homo sapiens 0-36 29258435-1 2017 BACKGROUND: Nonspecific phospholipase C (NPC), which belongs to a phospholipase C subtype, is a class of phospholipases that hydrolyzes the primary membrane phospholipids, such as phosphatidylcholine, to yield sn-1, 2-diacylglycerol and a phosphorylated head-group. Phosphatidylcholines 180-199 phosphoinositide phospholipase C 2-like Gossypium hirsutum 24-39 29258435-1 2017 BACKGROUND: Nonspecific phospholipase C (NPC), which belongs to a phospholipase C subtype, is a class of phospholipases that hydrolyzes the primary membrane phospholipids, such as phosphatidylcholine, to yield sn-1, 2-diacylglycerol and a phosphorylated head-group. Phosphatidylcholines 180-199 phosphoinositide phospholipase C 2-like Gossypium hirsutum 66-81 29030428-1 2017 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high-density lipoproteins (HDL) from discoidal to spherical particles. Phosphatidylcholines 129-148 lecithin-cholesterol acyltransferase Homo sapiens 38-42 29141586-13 2017 During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1. Phosphatidylcholines 61-80 phospholipase D P1 Arabidopsis thaliana 139-147 29199275-3 2017 Here we report a crystal structure of a LIMP-2 luminal domain dimer with bound cholesterol and phosphatidylcholine. Phosphatidylcholines 95-114 scavenger receptor class B, member 2 Mus musculus 40-46 29199275-4 2017 Binding of these lipids alters LIMP-2 from functioning as a glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine. Phosphatidylcholines 184-203 scavenger receptor class B, member 2 Mus musculus 31-37 29141586-13 2017 During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1. Phosphatidylcholines 82-84 phospholipase D P1 Arabidopsis thaliana 139-147 28988476-5 2017 This approach is demonstrated to differentiate sn-positional and double-bond-positional isomers, such as the regioisomeric phosphatidylcholines PC 16:0/18:1(n-9) and PC 18:1(n-9)/16:0, and has been integrated into an LC-MS3 workflow. Phosphatidylcholines 123-143 MS3 Homo sapiens 220-223 29142222-3 2017 In this work we have performed a biophysical study of human ATG3 interaction with membranes containing phosphatidylethanolamine, phosphatidylcholine and anionic phospholipids. Phosphatidylcholines 129-148 autophagy related 3 Homo sapiens 60-64 29093267-10 2017 Lipidomics and metabolomics revealed alterations of TG and phosphatidylcholine (PC) lipid species by miR-141/200c deficiency. Phosphatidylcholines 59-78 microRNA 141 Mus musculus 101-108 29093267-10 2017 Lipidomics and metabolomics revealed alterations of TG and phosphatidylcholine (PC) lipid species by miR-141/200c deficiency. Phosphatidylcholines 80-82 microRNA 141 Mus musculus 101-108 28855256-5 2017 The research in my lab and others demonstrated that the regulated and rate-limiting step in the choline pathway for PC biosynthesis was catalyzed by CTP:phosphocholine cytidylyltransferase. Phosphatidylcholines 116-118 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 149-188 28822686-3 2017 The present work applied simultaneous surface plasmon resonance and electrochemical impedance spectroscopy measurements to show that, in absence of the substrate, hMAGL can remove phospholipid molecules from the membrane and, thereby, disintegrate pre-formed, intact, tethered phospholipid bilayer membrane mimetics (tBLMs) composed of unsaturated phosphatidylcholines. Phosphatidylcholines 348-368 monoglyceride lipase Homo sapiens 163-168 28844900-7 2017 In further studies, NCL-240 encapsulated in phosphatidylcholine/cholesterol liposomes was combined with freely dissolved 2-DG. Phosphatidylcholines 44-63 nucleolin Homo sapiens 20-23 28114790-5 2017 Thus, the specific activities of the patient"s LPL determined with triolein emulsified with PC were significantly higher than those with PE, PS, PI or LPC as emulsifiers. Phosphatidylcholines 92-94 lipoprotein lipase Homo sapiens 47-50 29035283-0 2017 mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. Phosphatidylcholines 18-37 CREB regulated transcription coactivator 1 Mus musculus 0-6 29035283-7 2017 Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC). Phosphatidylcholines 166-185 CREB regulated transcription coactivator 1 Mus musculus 14-20 29035283-7 2017 Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC). Phosphatidylcholines 166-185 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 101-109 29035283-7 2017 Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC). Phosphatidylcholines 187-189 CREB regulated transcription coactivator 1 Mus musculus 14-20 29035283-7 2017 Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC). Phosphatidylcholines 187-189 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 101-109 29035283-8 2017 Increasing PC synthesis in mice lacking mTORC1 rescued hepatosteatosis and restored TAG secretion. Phosphatidylcholines 11-13 CREB regulated transcription coactivator 1 Mus musculus 40-46 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 134-153 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 28-38 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 134-153 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 39-45 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 155-157 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 28-38 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidylcholines 155-157 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 39-45 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 29054999-4 2017 The spectrum of self-antigens captured by CD1b skews toward abundant membrane phospholipids such as phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 100-119 CD1b molecule Homo sapiens 42-46 28855256-8 2017 The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC. Phosphatidylcholines 32-34 phosphatidylethanolamine N-methyltransferase Homo sapiens 64-108 28855256-8 2017 The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC. Phosphatidylcholines 32-34 phosphatidylethanolamine N-methyltransferase Homo sapiens 110-114 28855256-8 2017 The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC. Phosphatidylcholines 158-160 phosphatidylethanolamine N-methyltransferase Homo sapiens 64-108 28855256-8 2017 The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC. Phosphatidylcholines 158-160 phosphatidylethanolamine N-methyltransferase Homo sapiens 110-114 28687611-3 2017 A screening campaign revealed retinol (vitamin A alcohol) and all-trans retinoic acid (vitamin A acid) (RA) as hits that time-dependently (>=24 h) deplete phosphatidylcholine-bound polyunsaturated fatty acids (PUFA-PCs) from NIH-3T3 mouse fibroblasts while inducing Akt activation (EC50 0.1-1 microM). Phosphatidylcholines 158-177 thymoma viral proto-oncogene 1 Mus musculus 269-272 29044208-5 2017 TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated. Phosphatidylcholines 60-79 transforming growth factor beta 1 Homo sapiens 0-9 29044208-5 2017 TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated. Phosphatidylcholines 60-79 insulin like growth factor 1 Homo sapiens 14-19 29044208-5 2017 TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated. Phosphatidylcholines 81-83 transforming growth factor beta 1 Homo sapiens 0-9 29044208-5 2017 TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated. Phosphatidylcholines 81-83 insulin like growth factor 1 Homo sapiens 14-19 28802697-5 2017 The MP1-lipid membrane interaction was studied using Langmuir phosphatidylcholine and phosphatidylserine (PS) monolayers as model membrane systems. Phosphatidylcholines 62-81 pitrilysin metallopeptidase 1 Homo sapiens 4-7 28874751-3 2017 ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC). Phosphatidylcholines 186-205 ATPase phospholipid transporting 8A2 Homo sapiens 0-6 28676520-1 2017 BACKGROUND: PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Phosphatidylcholines 18-37 phosphatidylcholine transfer protein Homo sapiens 12-16 28874751-3 2017 ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC). Phosphatidylcholines 186-205 ATPase phospholipid transporting 8B1 Homo sapiens 126-132 28874751-3 2017 ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC). Phosphatidylcholines 207-209 ATPase phospholipid transporting 8A2 Homo sapiens 0-6 28874751-3 2017 ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC). Phosphatidylcholines 207-209 ATPase phospholipid transporting 8B1 Homo sapiens 126-132 28808571-3 2017 In addition, CRP may form a complex with oxidized low-density lipoprotein (oxLDL) via phosphatidylcholine, thus decreasing its pro-inflammatory effects within macrophages. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 13-16 28754826-0 2017 Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver. Phosphatidylcholines 45-64 secreted phosphoprotein 1 Mus musculus 0-11 28718450-4 2017 Here, all-atom molecular dynamics simulations of the mammalian StART-like PtdIns/phosphatidylcholine (PtdCho) transfer protein PITPalpha, both on membrane bilayers and in solvated systems, informed downstream biochemical analyses that tested key aspects of the hypotheses generated by the molecular dynamics simulations. Phosphatidylcholines 81-100 phosphatidylinositol transfer protein alpha Homo sapiens 127-136 28711489-7 2017 This study showed that STAT1 and interferon-regulated genes was up-regulated after the CD diet consumption and that the Stat1 mRNA level was negatively correlated with liver phosphatidylcholine level. Phosphatidylcholines 174-193 signal transducer and activator of transcription 1 Mus musculus 23-28 28711489-7 2017 This study showed that STAT1 and interferon-regulated genes was up-regulated after the CD diet consumption and that the Stat1 mRNA level was negatively correlated with liver phosphatidylcholine level. Phosphatidylcholines 174-193 signal transducer and activator of transcription 1 Mus musculus 120-125 28754826-3 2017 In mice, lack of OPN enhanced cholesterol 7alpha-hydroxylase (CYP7A1) levels and promoted loss of phosphatidylcholine (PC) content in liver; in vivo treatment with recombinant (r)OPN caused opposite effects. Phosphatidylcholines 98-117 secreted phosphoprotein 1 Mus musculus 17-20 28754826-3 2017 In mice, lack of OPN enhanced cholesterol 7alpha-hydroxylase (CYP7A1) levels and promoted loss of phosphatidylcholine (PC) content in liver; in vivo treatment with recombinant (r)OPN caused opposite effects. Phosphatidylcholines 119-121 secreted phosphoprotein 1 Mus musculus 17-20 28754826-6 2017 In vivo inhibition of cholesterogenesis normalized liver PC content in OPN-KO mice, demonstrating that OPN regulates the cross-talk between liver CHOL and PC metabolism. Phosphatidylcholines 57-59 secreted phosphoprotein 1 Mus musculus 103-106 28754826-8 2017 In conclusion, OPN regulates CYP7A1 levels and the metabolic fate of liver acetyl-CoA as a result of CHOL and PC metabolism interplay. Phosphatidylcholines 110-112 secreted phosphoprotein 1 Mus musculus 15-18 28821867-0 2017 Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer. Phosphatidylcholines 133-152 START domain containing 7 Mus musculus 57-63 28821867-1 2017 StarD7 facilitates phosphatidylcholine (PC) transfer to mitochondria, and is essential for mitochondrial homeostasis. Phosphatidylcholines 19-38 START domain containing 7 Mus musculus 0-6 28821867-5 2017 A truncated form of StarD7 lacking the TM domain is distributed in the inner space of the mitochondria, and cannot reverse mitochondrial abnormalities, such as complex formation and PC content, when re-expressed in StarD7-KO HEPA-1 cells. Phosphatidylcholines 182-184 START domain containing 7 Mus musculus 20-26 28903399-3 2017 We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells. Phosphatidylcholines 28-47 perlecan (heparan sulfate proteoglycan 2) Mus musculus 77-80 28786767-2 2017 The 10-kDa AtACBP6 is the smallest in this protein family, and recombinant AtACBP6 interacts with lipids in vitro by binding to acyl-CoA esters and phosphatidylcholine. Phosphatidylcholines 148-167 acyl-CoA-binding protein 6 Arabidopsis thaliana 11-18 28786767-2 2017 The 10-kDa AtACBP6 is the smallest in this protein family, and recombinant AtACBP6 interacts with lipids in vitro by binding to acyl-CoA esters and phosphatidylcholine. Phosphatidylcholines 148-167 acyl-CoA-binding protein 6 Arabidopsis thaliana 75-82 28551717-0 2017 Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection. Phosphatidylcholines 19-38 immunoglobulin heavy constant mu Mus musculus 39-42 28551717-3 2017 We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance. Phosphatidylcholines 43-62 immunoglobulin heavy constant mu Mus musculus 63-66 28726782-9 2017 Pretreatment with the PKCzeta activator phosphatidylcholine remarkably attenuated gut injury by suppressing apoptosis. Phosphatidylcholines 40-59 protein kinase C zeta Homo sapiens 22-29 28686226-4 2017 In DLBCL patients, overexpression of PCYT1A was in parallel with an increase in tumor MYC, as well as a decrease in serum choline metabolite phosphatidylcholine levels and an International Prognostic Index, indicating intermediate-high or high risk. Phosphatidylcholines 141-160 phosphate cytidylyltransferase 1A, choline Homo sapiens 37-43 28903399-0 2017 Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model. Phosphatidylcholines 0-19 erb-b2 receptor tyrosine kinase 2 Homo sapiens 64-68 28654865-5 2017 Of the two phosphatidylcholine-specific PLD enzymes, only PLD1, but not PLD2, mRNA was down-regulated by doxorubicin treatment. Phosphatidylcholines 11-30 phospholipase D1 Homo sapiens 58-62 28784961-9 2017 As previously observed, the PLC-delta1 PH domain is PI(4,5)P2 specific, shows weaker binding towards phosphatidylinositol 4-phosphate, and no binding to pure phosphatidylcholine SLBs. Phosphatidylcholines 158-177 phospholipase C delta 1 Homo sapiens 28-38 28903399-3 2017 We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells. Phosphatidylcholines 28-47 erb-b2 receptor tyrosine kinase 2 Homo sapiens 118-122 29450391-1 2017 Citicoline is the generic name of cytidine-5"-diphosphocholine (CDP-choline), an endogenous compound that is able to increase the levels of neurotransmitters in the central nervous system by interacting with the synthesis of cellular membranes phospholipids, especially phosphatidylcholine. Phosphatidylcholines 270-289 cut like homeobox 1 Homo sapiens 64-67 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. Phosphatidylcholines 154-173 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. Phosphatidylcholines 154-173 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 245-250 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. Phosphatidylcholines 175-177 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. Phosphatidylcholines 175-177 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 245-250 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. Phosphatidylcholines 184-186 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28385694-3 2017 Phosphatidylcholine-transfer protein (PC-TP), which exchanges phosphatidylcholines among membranes, is enriched in hepatocytes. Phosphatidylcholines 62-82 phosphatidylcholine transfer protein Mus musculus 0-36 28385694-3 2017 Phosphatidylcholine-transfer protein (PC-TP), which exchanges phosphatidylcholines among membranes, is enriched in hepatocytes. Phosphatidylcholines 62-82 phosphatidylcholine transfer protein Mus musculus 38-43 28385694-12 2017 Our current observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets. Phosphatidylcholines 109-129 phosphatidylcholine transfer protein Mus musculus 38-43 28434889-3 2017 Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine. Phosphatidylcholines 89-108 transmembrane 6 superfamily member 2 Homo sapiens 14-20 28434889-3 2017 Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine. Phosphatidylcholines 110-112 transmembrane 6 superfamily member 2 Homo sapiens 14-20 28220208-6 2017 ABCB4 flops phosphatidylcholine into the outer leaflet of the membrane to be extracted by bile salts in the canalicular space. Phosphatidylcholines 12-31 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28442572-9 2017 Finally, we demonstrated that CL activates the iPLA2gamma-mediated hydrolysis of arachidonic acid from phosphatidylcholine, thereby integrating the production of lipid messengers from different lipid classes in mitochondria. Phosphatidylcholines 103-122 patatin-like phospholipase domain containing 8 Mus musculus 47-57 28494778-5 2017 To evaluate the mRNA and protein levels of lysophosphatidylcholine acyltransferase (LPCAT), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC), qRT-PCR, western blotting and immunohistochemistry were performed. Phosphatidylcholines 47-66 lysophosphatidylcholine acyltransferase 1 Homo sapiens 84-89 28642062-0 2017 LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/beta-catenin signaling in zebrafish. Phosphatidylcholines 28-47 nuclear receptor subfamily 5, group A, member 2 Mus musculus 0-5 28642062-6 2017 Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development. Phosphatidylcholines 84-103 nuclear receptor subfamily 5, group A, member 2 Mus musculus 43-48 28642062-6 2017 Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development. Phosphatidylcholines 84-103 nuclear receptor subfamily 5, group A, member 2 Mus musculus 156-161 28642062-6 2017 Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development. Phosphatidylcholines 105-107 nuclear receptor subfamily 5, group A, member 2 Mus musculus 43-48 28642062-6 2017 Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development. Phosphatidylcholines 105-107 nuclear receptor subfamily 5, group A, member 2 Mus musculus 156-161 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 89-108 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 135-154 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 156-158 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 186-188 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28254415-7 2017 Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules. Phosphatidylcholines 106-125 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 77-82 28254415-7 2017 Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules. Phosphatidylcholines 127-129 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 77-82 28322795-1 2017 We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM). Phosphatidylcholines 282-301 interferon regulatory factor 6 Homo sapiens 49-53 28420794-3 2017 Here the results of five independent techniques-surface plasmon resonance, electrochemical impedance spectroscopy, bilayer overtone analysis, neutron reflectometry, and molecular dynamics simulations-suggest that alpha-tubulin"s amphipathic helix H10 is responsible for peripheral binding of dimeric tubulin to biomimetic "mitochondrial" membranes in a manner that differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidylethanolamine and phosphatidylcholine. Phosphatidylcholines 484-503 tubulin alpha 1b Homo sapiens 213-226 28336574-2 2017 Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane. Phosphatidylcholines 60-79 sphingomyelin synthase 2 Homo sapiens 119-130 28336574-2 2017 Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane. Phosphatidylcholines 60-79 sphingomyelin synthase 1 Homo sapiens 132-137 28336574-2 2017 Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane. Phosphatidylcholines 60-79 sphingomyelin synthase 2 Homo sapiens 155-159 28127842-2 2017 MDR3 mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 28322795-1 2017 We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM). Phosphatidylcholines 303-305 interferon regulatory factor 6 Homo sapiens 49-53 28438206-9 2017 The increased amounts of phosphatidylcholine and surfactant protein B in the lamellar body fractions were decreased in the Ad-Rab38 infected lungs. Phosphatidylcholines 25-44 RAB38, member RAS oncogene family Rattus norvegicus 123-131 28423060-0 2017 Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells. Phosphatidylcholines 0-19 C-X-C motif chemokine receptor 4 Homo sapiens 72-77 27614102-7 2017 RESULTS: Water vapour transmission rate demonstrated that as the phosphatidylcholine acyl chain length increased from C14, to C18, to C22, there was a corresponding increase in occlusive character. Phosphatidylcholines 65-84 Bardet-Biedl syndrome 9 Homo sapiens 126-129 28401922-2 2017 Although the phospholipid transfer protein Stard7 promotes uptake of PC by mitochondria, the importance of this pathway for mitochondrial and cellular homeostasis represents a significant knowledge gap. Phosphatidylcholines 69-71 START domain containing 7 Mus musculus 43-49 28401922-8 2017 These studies suggest that Stard7-mediated transfer of PC is crucial for mitochondrial homeostasis and that mitochondrial dysfunction contributes to altered barrier permeability in Stard7-deficient mice. Phosphatidylcholines 55-57 START domain containing 7 Mus musculus 27-33 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 1 Homo sapiens 37-51 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 1 Homo sapiens 53-56 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 1 Homo sapiens 58-63 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 58-61 28087695-8 2017 [14C]Choline and [3H]palmitate tracking shows that SMS1 overexpression apparently affects the partitioning of palmitate-enriched diacylglycerol between the phosphatidylcholine and triacylglycerol pathways, to the benefit of the former. Phosphatidylcholines 156-175 sphingomyelin synthase 1 Homo sapiens 51-55 28291718-4 2017 Disruption of the methionine cycle in HCU has the potential to impact multiple aspect of phospholipid (PL) metabolism by disruption of both the Kennedy pathway and phosphatidylethanolamine N-methyltransferase (PEMT) mediated synthesis of phosphatidylcholine (PC). Phosphatidylcholines 238-257 phosphatidylethanolamine N-methyltransferase Mus musculus 164-208 28291718-7 2017 A significant decrease in PC containing 20:4n6 which primarily formed by the methylation of phosphatidylethanolamine to PC was consistent with decreased flux through PEMT. Phosphatidylcholines 26-28 phosphatidylethanolamine N-methyltransferase Mus musculus 166-170 28225631-1 2017 C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 0-18 28225631-1 2017 C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 20-23 26803494-0 2017 Restrained Phosphatidylcholine Synthesis in a Cellular Model of Down"s Syndrome is Associated with the Overexpression of Dyrk1A. Phosphatidylcholines 11-30 dual specificity tyrosine phosphorylation regulated kinase 1A Homo sapiens 121-127 28119456-8 2017 An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecies of phosphatidylcholine carrying very long polyunsaturated fatty acid chains. Phosphatidylcholines 71-90 cell adhesion molecule 4 Homo sapiens 188-193 28119456-8 2017 An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecies of phosphatidylcholine carrying very long polyunsaturated fatty acid chains. Phosphatidylcholines 255-274 cell adhesion molecule 4 Homo sapiens 188-193 28277942-5 2017 These factors include the Myosin V motor protein Myo2 involved in transporting vacuolar vesicles along actin cables, the transmembrane protein Atg9 involved in the recruitment of large precursor hydrolase complexes to the vacuole, the phosphatidylinositol/ phosphatidylcholine (PI/PC) transfer protein Sec 14 and the SNARE chaperone Sec 18. Phosphatidylcholines 257-276 autophagy protein ATG9 Saccharomyces cerevisiae S288C 143-147 28177616-4 2017 Electrokinetic potential measurements of PI(4,5)P2 containing liposomes reveal that Ca2+ as well as Mg2+ reduce the zeta potential of liposomes to nearly background levels of pure phosphatidylcholine membranes. Phosphatidylcholines 180-199 carbonic anhydrase 2 Homo sapiens 84-87 26803494-10 2017 Here, we explored the potential role of Dyrk1A in the reduction of phosphatidylcholine concentrations in trisomic cells in the presence of oleic acid. Phosphatidylcholines 67-86 dual specificity tyrosine phosphorylation regulated kinase 1A Homo sapiens 40-46 26803494-11 2017 The downregulation of Dyrk1A by small interfering RNA (siRNA) in trisomic cells returned phosphatidylcholine concentrations up to similar levels to those of euploid cells in the presence of oleic acid. Phosphatidylcholines 89-108 dual specificity tyrosine phosphorylation regulated kinase 1A Homo sapiens 22-28 26803494-12 2017 Thus, our results highlight the role of Dyrk1A in brain development through the modulation of phosphatidylcholine location, levels and synthesis. Phosphatidylcholines 94-113 dual specificity tyrosine phosphorylation regulated kinase 1A Homo sapiens 40-46 28112912-3 2017 The MS2 fragments produced from protonated PC precursors and sodiated PC precursors were identified. Phosphatidylcholines 43-45 MS2 Homo sapiens 4-7 27769579-2 2017 Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 195-214 cut like homeobox 1 Homo sapiens 159-162 28196124-4 2017 The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM. Phosphatidylcholines 16-35 solute carrier family 38 member 3 Homo sapiens 123-127 28196124-4 2017 The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM. Phosphatidylcholines 16-35 solute carrier family 38 member 5 Homo sapiens 132-136 28196124-4 2017 The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM. Phosphatidylcholines 16-35 latexin Homo sapiens 204-207 27769579-2 2017 Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 216-218 cut like homeobox 1 Homo sapiens 159-162 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 155-174 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 155-174 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 176-178 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 176-178 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 28001010-5 2017 RESULTS: LBP gene expression was negatively associated with phosphatidylcholine, phosphatidylserine, and sphingomyelin relative abundance in vivo. Phosphatidylcholines 60-79 lipopolysaccharide binding protein Homo sapiens 9-12 27913621-8 2017 Finally, we have provided in vivo evidence showing that activation of PPARdelta by agonist L165041 in mice increased hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 254-273 peroxisome proliferator activator receptor delta Mus musculus 70-79 28127382-4 2017 RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). Phosphatidylcholines 118-137 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 30-34 28127382-4 2017 RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). Phosphatidylcholines 139-141 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 30-34 27760380-6 2017 ABCA1 dependent cholesterol efflux was higher than phosphatidylcholine efflux, was suppressed by probucol (ABCA1 inhibitor), AG490 (janus kinase-2 inhibitor), PD98059 (mitogen activated protein kinase kinase inhibitor) and pretreatment with beta-cyclodextrin (lowering membrane cholesterol). Phosphatidylcholines 51-70 ATP binding cassette subfamily A member 1 Bos taurus 0-5 27760380-6 2017 ABCA1 dependent cholesterol efflux was higher than phosphatidylcholine efflux, was suppressed by probucol (ABCA1 inhibitor), AG490 (janus kinase-2 inhibitor), PD98059 (mitogen activated protein kinase kinase inhibitor) and pretreatment with beta-cyclodextrin (lowering membrane cholesterol). Phosphatidylcholines 51-70 Janus kinase 2 Bos taurus 132-146 27591999-0 2016 Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice. Phosphatidylcholines 95-114 arsenite methyltransferase Mus musculus 12-58 27595588-3 2017 Here we show that PC biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PAH. Phosphatidylcholines 18-20 cell division control 2 Arabidopsis thaliana 94-121 27595588-3 2017 Here we show that PC biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PAH. Phosphatidylcholines 18-20 cell division control 2 Arabidopsis thaliana 123-129 27595588-5 2017 Expression of a CDK-insensitive version of PAH1 with a serine 162 to alanine substitution represses PC biosynthesis and also reduces the rate of cell division in early leaf development. Phosphatidylcholines 100-102 cell division control 2 Arabidopsis thaliana 16-19 27595588-5 2017 Expression of a CDK-insensitive version of PAH1 with a serine 162 to alanine substitution represses PC biosynthesis and also reduces the rate of cell division in early leaf development. Phosphatidylcholines 100-102 Lipin family protein Arabidopsis thaliana 43-47 27894770-2 2017 Three fluorogenic phosphatidylcholine analogs PC-1, PC-2, and PC-3 each containing the duo of 7-mercapto-4-methyl-coumarin fluorophore and 2,4-dinitroanaline quencher on either tail were synthesized from (R)-3-amino-1,2-propanediol and R-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol. Phosphatidylcholines 18-37 polycystin 1, transient receptor potential channel interacting Homo sapiens 46-50 29773019-2 2017 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). Phosphatidylcholines 221-240 phospholipase A2 group IB Homo sapiens 0-4 27256568-0 2017 Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages. Phosphatidylcholines 9-28 NLR family, pyrin domain containing 3 Mus musculus 55-60 27256568-4 2017 In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta. Phosphatidylcholines 48-67 NLR family, pyrin domain containing 3 Mus musculus 94-99 27256568-4 2017 In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta. Phosphatidylcholines 48-67 interleukin 1 beta Mus musculus 157-165 27256568-9 2017 Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages. Phosphatidylcholines 60-80 NLR family, pyrin domain containing 3 Mus musculus 120-125 27256568-9 2017 Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages. Phosphatidylcholines 60-80 interleukin 1 beta Mus musculus 169-177 28683445-2 2017 Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) and thereby can regulate intracellular free-AA levels. Phosphatidylcholines 35-54 lysophosphatidylcholine acyltransferase 3 Homo sapiens 74-80 28683445-2 2017 Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) and thereby can regulate intracellular free-AA levels. Phosphatidylcholines 75-77 lysophosphatidylcholine acyltransferase 3 Homo sapiens 31-72 27502364-2 2016 B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions. Phosphatidylcholines 214-220 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 28-73 27502364-2 2016 B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions. Phosphatidylcholines 214-220 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 75-83 27723344-3 2016 Using microsecond-long molecular dynamics simulations, we analyzed interaction of CYP3A4 with bilayers composed of lipids differing in their polar head groups, i.e., phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. Phosphatidylcholines 166-185 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 82-88 27645136-2 2016 It confers freezing tolerance in transgenic Arabidopsis, possibly by its interaction with lipids as indicated by the binding of acyl-CoA esters and phosphatidylcholine to recombinant AtACBP6. Phosphatidylcholines 148-167 acyl-CoA-binding protein 6 Arabidopsis thaliana 183-190 27883027-3 2016 NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC). Phosphatidylcholines 73-92 patatin like phospholipase domain containing 6 Gallus gallus 0-3 27883027-3 2016 NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC). Phosphatidylcholines 94-96 patatin like phospholipase domain containing 6 Gallus gallus 0-3 27746179-3 2016 By the mass spectrometry analysis, we demonstrate that Yor022c is actually a phospholipase displaying sn-1-specific activity toward phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid, generating 2-acyl lysophospholipids. Phosphatidylcholines 132-151 putative carboxylic ester hydrolase Saccharomyces cerevisiae S288C 55-62 27694445-0 2016 StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria. Phosphatidylcholines 48-67 START domain containing 7 Mus musculus 0-6 27694445-3 2016 In a previous study, we found that StarD7 mediates the intracellular transfer of PC to mitochondria. Phosphatidylcholines 81-83 START domain containing 7 Mus musculus 35-41 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 133-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 27575989-3 2016 In the present study, we aimed to evaluate the putative protective effect of PC on carbon tetrachloride (CCl4)-induced nephrotoxicity in ICR mice. Phosphatidylcholines 77-79 chemokine (C-C motif) ligand 4 Mus musculus 105-109 27575989-8 2016 Comparative analysis of histopathological injuries revealed that PC abrogated the nephrotoxicity of CCl4 at 7 days. Phosphatidylcholines 65-67 chemokine (C-C motif) ligand 4 Mus musculus 100-104 27575989-9 2016 Accordingly, PC also improved renal fibrosis induced by CCl4. Phosphatidylcholines 13-15 chemokine (C-C motif) ligand 4 Mus musculus 56-60 27575989-13 2016 These results strongly suggest that PC can protect against oxidative damage induced by CCl4 in the kidney and enhance recovery from renal disorders. Phosphatidylcholines 36-38 chemokine (C-C motif) ligand 4 Mus musculus 87-91 26567110-4 2016 This study originally describes that lysophosphatidylcholine (LPtdCho), either exogenously supplied or generated by the imbalance of PtdCho metabolism through the enzymatic action of cytosolic phospholipase A2, acts as a neurotrophic-like factor. Phosphatidylcholines 63-69 phospholipase A2 group IVA Homo sapiens 183-209 27436233-7 2016 Overexpression of SDC1 in planta increased levels of ethanolamine, phosphatidylethanolamine, and phosphatidylcholine both in leaves and siliques. Phosphatidylcholines 97-116 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 18-22 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 133-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 154-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 154-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 256-275 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 53-92 27731369-4 2016 PGP inactivation attenuated triosephosphate isomerase activity, increased triglyceride levels at the expense of the cellular phosphatidylcholine content, and inhibited cell proliferation. Phosphatidylcholines 125-144 phosphoglycolate phosphatase Mus musculus 0-3 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 256-275 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 94-97 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 256-275 cut-like homeobox 1 Rattus norvegicus 183-186 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 277-279 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 53-92 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 277-279 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 94-97 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 277-279 cut-like homeobox 1 Rattus norvegicus 183-186 27402832-10 2016 Instead, the dynamic TIM23 complex is destabilized when the PC levels are reduced, whereas the TIM22 complex remains intact. Phosphatidylcholines 60-62 translocase of inner mitochondrial membrane 23 Homo sapiens 21-26 27457520-4 2016 Cho phosphotransferase CHPT1, identified as a direct ERalpha-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis. Phosphatidylcholines 158-177 choline phosphotransferase 1 Danio rerio 23-28 27457520-4 2016 Cho phosphotransferase CHPT1, identified as a direct ERalpha-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis. Phosphatidylcholines 158-177 estrogen receptor 1 Danio rerio 53-60 27554972-2 2016 StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis. Phosphatidylcholines 35-54 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 27554972-2 2016 StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis. Phosphatidylcholines 56-58 StAR related lipid transfer domain containing 7 Homo sapiens 0-6 27554972-3 2016 Since inhibition of PC synthesis may lead to endoplasmic reticulum (ER) stress we hypothesized that StarD7 may be involved in maintaining cell homeostasis. Phosphatidylcholines 20-22 StAR related lipid transfer domain containing 7 Homo sapiens 100-106 27713745-0 2016 Phosphocholine-Specific Antibodies Improve T-Dependent Antibody Responses against OVA Encapsulated into Phosphatidylcholine-Containing Liposomes. Phosphatidylcholines 104-123 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 82-85 27611931-1 2016 Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG). Phosphatidylcholines 188-207 monoacylglycerol O-acyltransferase 1 Homo sapiens 0-34 27611931-1 2016 Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG). Phosphatidylcholines 188-207 monoacylglycerol O-acyltransferase 1 Homo sapiens 36-42 27436846-1 2016 RATIONALE: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 25-43 27436846-1 2016 RATIONALE: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 45-51 27402832-12 2016 We conclude that reduced PC levels differentially affect the TIM22 and TIM23 complexes in mitochondrial protein transport. Phosphatidylcholines 25-27 translocase of inner mitochondrial membrane 22 Homo sapiens 61-66 27402832-12 2016 We conclude that reduced PC levels differentially affect the TIM22 and TIM23 complexes in mitochondrial protein transport. Phosphatidylcholines 25-27 translocase of inner mitochondrial membrane 23 Homo sapiens 71-76 27317427-6 2016 Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine. Phosphatidylcholines 85-104 phospholipase A2 group VI Homo sapiens 13-19 27317427-6 2016 Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine. Phosphatidylcholines 85-104 patatin like phospholipase domain containing 6 Homo sapiens 21-27 27317427-6 2016 Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine. Phosphatidylcholines 85-104 patatin like phospholipase domain containing 4 Homo sapiens 31-37 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 113-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-175 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 113-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-175 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 27009527-7 2016 Binding assays revealed that PLD re-localized from the aqueous phase to the solvent-buffer interface, where the enzymatic reaction takes place, in the presence of both, the salt and PC. Phosphatidylcholines 182-184 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 27581838-2 2016 Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism. Phosphatidylcholines 93-112 phospholipid transfer protein Homo sapiens 0-29 27581838-2 2016 Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism. Phosphatidylcholines 93-112 phospholipid transfer protein Homo sapiens 31-35 27581838-2 2016 Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism. Phosphatidylcholines 93-112 lecithin-cholesterol acyltransferase Homo sapiens 41-77 27581838-2 2016 Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism. Phosphatidylcholines 93-112 lecithin-cholesterol acyltransferase Homo sapiens 79-83 27246581-5 2016 We also show that in addition to phosphatidylcholine alteration, there is also an effect in the ratio of phosphatidylcholine/phosphatidylethanolamine in serum of mice induced with the disease and that this change may be due to increased expression of the phosphatidylethanolamine N-methyltransferase gene. Phosphatidylcholines 105-124 phosphatidylethanolamine N-methyltransferase Mus musculus 255-299 27574784-9 2016 Desorption electrospray ionization mass spectrometry (DESI MS)-based imaging of cell lines and tumor tissues revealed changes in phosphatidylcholines levels upon treatment. Phosphatidylcholines 129-149 desumoylating isopeptidase 2 Homo sapiens 54-58 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 103-122 ATPase phospholipid transporting 10A (putative) Homo sapiens 38-44 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 13-32 lipase H Homo sapiens 82-98 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 13-32 lipase H Homo sapiens 100-104 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 34-36 lipase H Homo sapiens 82-98 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 34-36 lipase H Homo sapiens 100-104 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 139-141 lipase H Homo sapiens 82-98 27108109-1 2016 DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system. Phosphatidylcholines 139-141 lipase H Homo sapiens 100-104 27193303-0 2016 Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins. Phosphatidylcholines 150-169 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 114-119 27193303-4 2016 Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis. Phosphatidylcholines 124-143 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 41-46 27193303-4 2016 Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis. Phosphatidylcholines 124-143 Sec14p-like phosphatidylinositol transfer family protein Arabidopsis thaliana 52-58 27193303-4 2016 Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis. Phosphatidylcholines 145-151 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 41-46 27193303-4 2016 Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis. Phosphatidylcholines 145-151 Sec14p-like phosphatidylinositol transfer family protein Arabidopsis thaliana 52-58 26961241-5 2016 The POPC conjugate of the NS5B inhibitors was assumed to result from two sequential reactions: hydroxylation of the bicyclic methine to a tertiary alcohol and addition of POPC by CDP-choline: 1,2-diacylglycerol cholinephosphotransferase, an enzyme responsible for the final step in the biosynthesis of phosphatidylcholine. Phosphatidylcholines 302-321 cut like homeobox 1 Homo sapiens 179-182 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 178-197 diacylglycerol kinase beta Homo sapiens 204-207 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 178-197 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 199-201 diacylglycerol kinase beta Homo sapiens 204-207 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 199-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 27347790-0 2016 Effect of Cholesterol on the Interaction of Cytochrome P450 Substrate Drug Chlorzoxazone with the Phosphatidylcholine Bilayer. Phosphatidylcholines 98-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 27347790-6 2016 In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction. Phosphatidylcholines 154-173 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-83 27347790-6 2016 In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction. Phosphatidylcholines 175-177 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-83 26721598-6 2016 We will show that oxidative modifications of PL by HOCl have a considerable impact on the PLA2 digestibility, i.e., oxidation of the unsaturated fatty acyl residues leads to a reduced digestibility of both PC and PE. Phosphatidylcholines 206-208 phospholipase A2 group IB Homo sapiens 90-94 27383786-8 2016 This is explained by an increase in microsomal phospholipids containing polyunsaturated fatty acids, linked to an LXRalpha-dependent increase in expression of enzymes mediating phosphatidylcholine biosynthesis and incorporation of polyunsaturated fatty acids into phospholipids. Phosphatidylcholines 177-196 nuclear receptor subfamily 1, group H, member 3 Mus musculus 114-122 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 103-122 ATPase phospholipid transporting 8B1 Homo sapiens 45-51 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 103-122 ATPase phospholipid transporting 11A Homo sapiens 57-63 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 103-122 ATPase phospholipid transporting 11C Homo sapiens 64-70 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 124-126 ATPase phospholipid transporting 10A (putative) Homo sapiens 38-44 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 124-126 ATPase phospholipid transporting 8B1 Homo sapiens 45-51 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 124-126 ATPase phospholipid transporting 11A Homo sapiens 57-63 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. Phosphatidylcholines 124-126 ATPase phospholipid transporting 11C Homo sapiens 64-70 27032901-0 2016 Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. Phosphatidylcholines 16-35 insulin Homo sapiens 80-87 27165857-2 2016 Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS) 1 in the Golgi and SMS2 at the plasma membrane. Phosphatidylcholines 60-79 sphingomyelin synthase 1 Homo sapiens 119-138 27165857-2 2016 Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS) 1 in the Golgi and SMS2 at the plasma membrane. Phosphatidylcholines 60-79 sphingomyelin synthase 2 Homo sapiens 156-160 27112167-7 2016 The antifungal azoles, posaconazole, itraconazole, and ketoconazole, significantly inhibited MDR3-mediated phosphatidylcholine secretion. Phosphatidylcholines 107-126 ATP binding cassette subfamily B member 4 Homo sapiens 93-97 27073147-2 2016 Choline kinase alpha (ChoKalpha) is a key mediator of these changes, as it represents the first committed step in the Kennedy pathway of phosphatidylcholine biosynthesis and ChoKalpha expression is upregulated in many human cancers. Phosphatidylcholines 137-156 choline kinase alpha Homo sapiens 0-20 27320911-3 2016 SREBPs can be regulated in response to membrane cholesterol and we also found that low levels of phosphatidylcholine (a methylated phospholipid) led to SBP-1/SREBP-1 maturation in C. elegans or mammalian models. Phosphatidylcholines 97-116 BHLH domain-containing protein Caenorhabditis elegans 152-157 27320911-3 2016 SREBPs can be regulated in response to membrane cholesterol and we also found that low levels of phosphatidylcholine (a methylated phospholipid) led to SBP-1/SREBP-1 maturation in C. elegans or mammalian models. Phosphatidylcholines 97-116 sterol regulatory element binding transcription factor 1 Homo sapiens 158-165 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 85-104 phospholipase A2, group IB, pancreas Mus musculus 0-16 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 85-104 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 18-23 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 106-108 phospholipase A2, group IB, pancreas Mus musculus 0-16 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 106-108 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 18-23 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidylcholines 32-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidylcholines 54-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 27206796-2 2016 Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 muM and inhibited tumor xenograft growth in mice. Phosphatidylcholines 71-90 choline kinase alpha Mus musculus 14-34 27206796-2 2016 Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 muM and inhibited tumor xenograft growth in mice. Phosphatidylcholines 71-90 choline kinase alpha Mus musculus 36-40 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 0-22 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 24-28 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 46-89 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 96-101 26873001-0 2016 Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia. Phosphatidylcholines 53-72 carbonic anhydrase 1 Rattus norvegicus 92-95 26873001-7 2016 IMS detected significant molecular changes after TGI in the same CA1 domain: increase of PC (diacyl-16:0/22:6) in the superacute phase and increase of PC (diacyl-16:0/18:1) in the subacute to chronic phases. Phosphatidylcholines 89-91 carbonic anhydrase 1 Rattus norvegicus 65-68 27149373-1 2016 Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. Phosphatidylcholines 87-106 choline kinase beta Homo sapiens 0-19 27149373-1 2016 Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. Phosphatidylcholines 87-106 creatine kinase B Homo sapiens 21-27 26921317-3 2016 We propose that Prdx6 LB targeting facilitates its role in the metabolism of lung surfactant phosphatidylcholine (PC). Phosphatidylcholines 93-112 peroxiredoxin 6 Mus musculus 16-21 26695710-1 2016 Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 144-163 phospholipase D2 Homo sapiens 0-16 26695710-1 2016 Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 144-163 phospholipase D2 Homo sapiens 18-22 26695710-1 2016 Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 165-167 phospholipase D2 Homo sapiens 0-16 26695710-1 2016 Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 165-167 phospholipase D2 Homo sapiens 18-22 26454209-3 2016 Here we tested the ability of reconstituted HDL (rHDL) consisting of human apoA-I reconstituted with soy phosphatidylcholine for its ability to lower amyloid beta (Abeta) levels in symptomatic APP/PS1 mice, a well-characterized preclinical model of amyloidosis. Phosphatidylcholines 105-124 amyloid beta precursor protein Homo sapiens 150-162 26454209-3 2016 Here we tested the ability of reconstituted HDL (rHDL) consisting of human apoA-I reconstituted with soy phosphatidylcholine for its ability to lower amyloid beta (Abeta) levels in symptomatic APP/PS1 mice, a well-characterized preclinical model of amyloidosis. Phosphatidylcholines 105-124 amyloid beta precursor protein Homo sapiens 164-169 27110687-2 2016 The current study tested the possibility that increased expression of lysophosphatidylcholine acyltransferase-3 (LPCAT3), an enzyme that converts lysophosphatidylcholine to phosphatidylcholine in the liver, may alleviate the adverse effects of lysophospholipids absorbed after a lipid-glucose mixed meal. Phosphatidylcholines 74-93 lysophosphatidylcholine acyltransferase 3 Mus musculus 113-119 26651393-0 2016 Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Phosphatidylcholines 10-29 cholinergic receptor nicotinic alpha 7 subunit Homo sapiens 98-104 26921317-3 2016 We propose that Prdx6 LB targeting facilitates its role in the metabolism of lung surfactant phosphatidylcholine (PC). Phosphatidylcholines 114-116 peroxiredoxin 6 Mus musculus 16-21 26921317-8 2016 The content of total phospholipid, PC, and disaturated PC in lung tissue homogenate, bronchoalveolar lavage fluid, and lung LB was increased significantly in Prdx6-S32T mutant lungs, whereas degradation of internalized [(3)H]dipalmitoyl-PC was significantly decreased. Phosphatidylcholines 35-37 peroxiredoxin 6 Mus musculus 158-163 26921317-10 2016 These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine. Phosphatidylcholines 106-125 peroxiredoxin 6 Mus musculus 47-52 26907692-8 2016 Depletion of LB PRDX6 in AP-3- or LIMP-2/SCARB2-deficient mice correlates with phospholipid accumulation in lamellar bodies and with defective intraluminal degradation of LB disaturated phosphatidylcholine. Phosphatidylcholines 186-205 peroxiredoxin 6 Mus musculus 16-21 26821209-7 2016 Reduced membrane level of PKCepsilon and PKCdelta was associated with significant incorporation of DHA in all phospholipids, including phosphatidylcholine which is a major source of phosphatidic acid. Phosphatidylcholines 135-154 protein kinase C delta Homo sapiens 41-49 26797396-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26797396-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 86-105 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26797396-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26797396-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26921357-6 2016 Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins. Phosphatidylcholines 177-196 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 22-27 26828064-1 2016 Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylcholine remodeling in the small intestine and liver. Phosphatidylcholines 4-23 lysophosphatidylcholine acyltransferase 3 Mus musculus 43-49 26830860-6 2016 A linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that LPC generated by Prdx6 PLA2activity remained bound to the enzyme for the reacylation reaction. Phosphatidylcholines 87-89 peroxiredoxin 6 Mus musculus 123-128 26830860-6 2016 A linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that LPC generated by Prdx6 PLA2activity remained bound to the enzyme for the reacylation reaction. Phosphatidylcholines 87-89 phospholipase A2, group V Mus musculus 129-133 26830860-8 2016 Thus, Prdx6 is a complete enzyme comprising both PLA2and LPCAT activities for the remodeling pathway of PC synthesis or for repair of membrane lipid peroxidation. Phosphatidylcholines 58-60 peroxiredoxin 6 Mus musculus 6-11 26821209-7 2016 Reduced membrane level of PKCepsilon and PKCdelta was associated with significant incorporation of DHA in all phospholipids, including phosphatidylcholine which is a major source of phosphatidic acid. Phosphatidylcholines 135-154 protein kinase C epsilon Homo sapiens 26-36 26921357-6 2016 Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins. Phosphatidylcholines 177-196 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 136-141 26921357-6 2016 Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins. Phosphatidylcholines 198-204 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 22-27 26921357-6 2016 Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins. Phosphatidylcholines 198-204 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 136-141 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 0-30 26936140-7 2016 Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism. Phosphatidylcholines 25-27 interleukin 2 Rattus norvegicus 131-135 26936140-7 2016 Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism. Phosphatidylcholines 25-27 Cd28 molecule Rattus norvegicus 183-187 26936140-7 2016 Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism. Phosphatidylcholines 25-27 cytotoxic T-lymphocyte-associated protein 4 Rattus norvegicus 199-204 26773402-5 2016 RESULTS: Phosphatidylcholines, when expressed as the relative amount compared with total phospholipids and sphingolipids, were similar in both HDL2 and HDL3 in the two groups. Phosphatidylcholines 9-29 junctophilin 3 Homo sapiens 143-147 26773402-5 2016 RESULTS: Phosphatidylcholines, when expressed as the relative amount compared with total phospholipids and sphingolipids, were similar in both HDL2 and HDL3 in the two groups. Phosphatidylcholines 9-29 HDL3 Homo sapiens 152-156 26381674-0 2016 Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth. Phosphatidylcholines 84-103 scavenger receptor class B member 1 Homo sapiens 45-49 26381674-6 2016 Trafficking of a fluorescent phosphatidylcholine analogue to Chlamydia was blocked by the inhibition of CLA1 or ABCA1 function, indicating a critical role for these transporters in phosphatidylcholine acquisition by this organism. Phosphatidylcholines 29-48 scavenger receptor class B member 1 Homo sapiens 104-108 26381674-6 2016 Trafficking of a fluorescent phosphatidylcholine analogue to Chlamydia was blocked by the inhibition of CLA1 or ABCA1 function, indicating a critical role for these transporters in phosphatidylcholine acquisition by this organism. Phosphatidylcholines 181-200 scavenger receptor class B member 1 Homo sapiens 104-108 26620528-0 2016 ALA10, a Phospholipid Flippase, Controls FAD2/FAD3 Desaturation of Phosphatidylcholine in the ER and Affects Chloroplast Lipid Composition in Arabidopsis thaliana. Phosphatidylcholines 67-86 fatty acid desaturase 2 Arabidopsis thaliana 41-45 26620528-0 2016 ALA10, a Phospholipid Flippase, Controls FAD2/FAD3 Desaturation of Phosphatidylcholine in the ER and Affects Chloroplast Lipid Composition in Arabidopsis thaliana. Phosphatidylcholines 67-86 fatty acid desaturase 3 Arabidopsis thaliana 46-50 26620528-5 2016 ALA10 interacts also with FATTY ACID DESATURASE2 (FAD2), and modification of ALA10 expression affects phosphatidylcholine (PC) fatty acyl desaturation by disturbing the balance between FAD2 and FAD3 activities. Phosphatidylcholines 102-121 fatty acid desaturase 2 Arabidopsis thaliana 185-189 26620528-5 2016 ALA10 interacts also with FATTY ACID DESATURASE2 (FAD2), and modification of ALA10 expression affects phosphatidylcholine (PC) fatty acyl desaturation by disturbing the balance between FAD2 and FAD3 activities. Phosphatidylcholines 102-121 fatty acid desaturase 3 Arabidopsis thaliana 194-198 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Phosphatidylcholines 46-65 serpin family B member 3 Homo sapiens 165-168 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Phosphatidylcholines 67-69 serpin family B member 3 Homo sapiens 165-168 26971994-5 2016 We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels. Phosphatidylcholines 162-181 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 61-70 26971994-5 2016 We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels. Phosphatidylcholines 162-181 interleukin 1 beta Homo sapiens 85-93 26971994-5 2016 We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels. Phosphatidylcholines 183-185 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 61-70 26971994-5 2016 We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels. Phosphatidylcholines 183-185 interleukin 1 beta Homo sapiens 85-93 26971994-5 2016 We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels. Phosphatidylcholines 216-218 interleukin 1 beta Homo sapiens 85-93 26880640-3 2016 The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), a retinol-related enzyme that transfers an acyl group derived from an sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 209-228 lecithin retinol acyltransferase Homo sapiens 81-113 26880640-3 2016 The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), a retinol-related enzyme that transfers an acyl group derived from an sn-1 position of phosphatidylcholine to retinol. Phosphatidylcholines 209-228 lecithin retinol acyltransferase Homo sapiens 115-119 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 32-36 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 38-43 26887851-8 2016 When repeated on the isogenic strain deleted in OPI1, encoding for a transcriptional repressor of genes involved in PC biosynthesis, FTIR analysis revealed that not only the PC levels were affected but also the cell membrane/wall composition and the accumulation of protein aggregates, resulting in higher growth rate in the presence of the stressing agent. Phosphatidylcholines 116-118 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 48-52 26888014-3 2016 Here, we report that ENPP6, a choline-specific phosphodiesterase, hydrolyzes glycerophosphocholine (GPC), a degradation product of PC, as a physiological substrate and participates in choline metabolism. Phosphatidylcholines 101-103 ectonucleotide pyrophosphatase/phosphodiesterase 6 Mus musculus 21-26 26807595-3 2016 Longer-chain phosphatidylcholine lipids, which form the lining of milk ducts and milk fat globules, enhanced RCM kappa-casein fibril formation irrespective of whether the lipids were in a monomeric or micellar state, whereas shorter-chain phospholipids and triglycerides had little effect. Phosphatidylcholines 13-32 casein kappa Homo sapiens 113-125 26888014-4 2016 ENPP6 is highly expressed in liver sinusoidal endothelial cells and developing oligodendrocytes, which actively incorporate choline and synthesize PC. Phosphatidylcholines 147-149 ectonucleotide pyrophosphatase/phosphodiesterase 6 Mus musculus 0-5 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidylcholines 59-78 phospholipase D1 Homo sapiens 0-16 26888014-6 2016 The choline moiety of GPC was incorporated into PC in an ENPP6-dependent manner both in vivo and in vitro. Phosphatidylcholines 23-25 ectonucleotide pyrophosphatase/phosphodiesterase 6 Mus musculus 57-62 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidylcholines 59-78 phospholipase D1 Homo sapiens 18-22 25316339-0 2016 Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex. Phosphatidylcholines 76-95 tachykinin 1 Mus musculus 0-11 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidylcholines 80-82 phospholipase D1 Homo sapiens 0-16 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidylcholines 80-82 phospholipase D1 Homo sapiens 18-22 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. Phosphatidylcholines 94-113 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. Phosphatidylcholines 94-113 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. Phosphatidylcholines 115-117 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. Phosphatidylcholines 115-117 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 25752890-4 2016 Protein expression of lysophosphatidylcholine acyltransferase 1 (LPCAT1), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) in the presence of acyl-CoA in Lands" cycle, was immunohistochemically analyzed in 182 gastric cancer specimens. Phosphatidylcholines 26-45 lysophosphatidylcholine acyltransferase 1 Homo sapiens 65-71 25752890-4 2016 Protein expression of lysophosphatidylcholine acyltransferase 1 (LPCAT1), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) in the presence of acyl-CoA in Lands" cycle, was immunohistochemically analyzed in 182 gastric cancer specimens. Phosphatidylcholines 66-68 lysophosphatidylcholine acyltransferase 1 Homo sapiens 22-63 25316339-0 2016 Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex. Phosphatidylcholines 76-95 nitric oxide synthase 1, neuronal Mus musculus 142-146 26756862-0 2016 Impact of phosphatidylcholine liposomes on the compositional changes of VLDL during lipoprotein lipase (LPL)-mediated lipolysis. Phosphatidylcholines 10-29 lipoprotein lipase Homo sapiens 84-102 26756862-0 2016 Impact of phosphatidylcholine liposomes on the compositional changes of VLDL during lipoprotein lipase (LPL)-mediated lipolysis. Phosphatidylcholines 10-29 lipoprotein lipase Homo sapiens 104-107 26789121-1 2016 ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes. Phosphatidylcholines 65-84 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25283521-1 2016 Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Rattus norvegicus 0-30 25283521-1 2016 Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Rattus norvegicus 32-36 25283521-1 2016 Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Rattus norvegicus 50-73 25283521-1 2016 Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Rattus norvegicus 75-80 26172874-11 2016 CONCLUSION: Inhibition of ASBT reduces BA pool size and retention of hydrophobic BA, favorably alters the biliary PC/BA ratio, profoundly changes the hepatic transcriptome, attenuates recruitment of leukocytes, and abrogates progression of murine sclerosing cholangitis. Phosphatidylcholines 114-116 solute carrier family 10, member 2 Mus musculus 26-30 26153658-1 2016 BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects. Phosphatidylcholines 96-115 ATP binding cassette subfamily B member 4 Homo sapiens 46-51 26153658-1 2016 BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects. Phosphatidylcholines 96-115 ATP binding cassette subfamily B member 4 Homo sapiens 116-120 26153658-10 2016 Phosphatidylcholine efflux activity was decreased to 56-18% of reference levels for MDR3 mutants T175A, A250T and S320F. Phosphatidylcholines 0-19 ATP binding cassette subfamily B member 4 Homo sapiens 84-88 26212931-6 2016 Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels. Phosphatidylcholines 45-64 vascular endothelial growth factor A Homo sapiens 132-136 26212931-6 2016 Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels. Phosphatidylcholines 45-64 angiopoietin 2 Homo sapiens 141-155 26212931-6 2016 Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels. Phosphatidylcholines 45-64 C-X-C motif chemokine ligand 8 Homo sapiens 188-201 26789121-1 2016 ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes. Phosphatidylcholines 65-84 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 26267291-2 2016 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1). Phosphatidylcholines 82-102 nuclear receptor subfamily 5, group A, member 2 Mus musculus 144-168 26212962-0 2016 Phospholipase A1-catalyzed hydrolysis of soy phosphatidylcholine to prepare l-alpha-glycerylphosphorylcholine in organic-aqueous media. Phosphatidylcholines 45-64 lipase H Homo sapiens 0-16 26212962-1 2016 This study aimed to optimize the preparation of L-alpha-glycerylphosphorylcholine (l-alpha-GPC) via phospholipase A1 (Lecitase Ultra)-catalyzed hydrolysis of soy phosphatidylcholine (PC). Phosphatidylcholines 162-181 lipase H Homo sapiens 100-116 26212962-1 2016 This study aimed to optimize the preparation of L-alpha-glycerylphosphorylcholine (l-alpha-GPC) via phospholipase A1 (Lecitase Ultra)-catalyzed hydrolysis of soy phosphatidylcholine (PC). Phosphatidylcholines 92-94 lipase H Homo sapiens 100-116 26267291-6 2016 This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion. Phosphatidylcholines 227-229 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 120-150 26267291-6 2016 This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion. Phosphatidylcholines 227-229 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 152-156 26267291-6 2016 This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion. Phosphatidylcholines 227-229 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 157-162 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 117-136 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-22 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 117-136 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 24-28 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 117-136 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 43-85 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 117-136 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 87-92 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 138-140 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-22 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 138-140 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 24-28 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 138-140 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 43-85 26542370-1 2016 Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Phosphatidylcholines 138-140 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 87-92 26267291-2 2016 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1). Phosphatidylcholines 82-102 nuclear receptor subfamily 5, group A, member 2 Mus musculus 170-175 26267291-2 2016 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1). Phosphatidylcholines 104-107 nuclear receptor subfamily 5, group A, member 2 Mus musculus 144-168 26267291-2 2016 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1). Phosphatidylcholines 104-107 nuclear receptor subfamily 5, group A, member 2 Mus musculus 170-175 26836186-8 2016 Further phosphatidylcholine species (34:6, 36:5, 40:6) correlated with cerebrospinal fluid tau (p < 0.05), and plasmalogen ethanolamine species (34:2, 36:,4) correlated with both cerebrospinal fluid tau and brain amyloid load within the MC group (p < 0.05). Phosphatidylcholines 8-27 microtubule associated protein tau Homo sapiens 91-94 27738646-13 2016 Liposomes bearing oxidized phosphatidylcholine without pCRP promoted a uniform M1 macrophage and Th1 pro-inflammatory response. Phosphatidylcholines 27-46 negative elongation factor complex member C/D Homo sapiens 97-100 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 142-161 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 27524956-7 2016 Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations. Phosphatidylcholines 177-196 aldehyde dehydrogenase 1 family member B1 Homo sapiens 223-230 27524956-7 2016 Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations. Phosphatidylcholines 177-196 membrane bound O-acyltransferase domain containing 1 Homo sapiens 232-238 27524956-7 2016 Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations. Phosphatidylcholines 177-196 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 240-244 27524956-7 2016 Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations. Phosphatidylcholines 177-196 phospholipase B1 Homo sapiens 249-253 26470810-2 2015 An exploration of intracellular signaling pathways revealed the TRH-induced current to be insensitive to phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitors, but reduced by D609, an inhibitor of phosphatidylcholine-specific PLC (PC-PLC). Phosphatidylcholines 209-228 thyrotropin releasing hormone Rattus norvegicus 64-67 26665171-3 2015 We show that protein arginine methyltransferase 8 (PRMT8) acts as a phospholipase that directly hydrolyzes PC, generating choline and phosphatidic acid. Phosphatidylcholines 107-109 protein arginine N-methyltransferase 8 Mus musculus 13-49 26665171-3 2015 We show that protein arginine methyltransferase 8 (PRMT8) acts as a phospholipase that directly hydrolyzes PC, generating choline and phosphatidic acid. Phosphatidylcholines 107-109 protein arginine N-methyltransferase 8 Mus musculus 51-56 26665171-6 2015 Choline and acetylcholine levels were significantly decreased, whereas PC levels were increased, in the cerebellum of prmt8 (-/-) mice. Phosphatidylcholines 71-73 protein arginine N-methyltransferase 8 Mus musculus 118-123 26629827-12 2015 CONCLUSIONS: Metformin and phosphatidylcholine attenuated lipopolysaccharide induced toll-like receptor 4 overexpression and overproduction of pro-inflammatory cytokines; however, their efficacy depended on combined presence of non-alcoholic fatty liver disease, metabolic syndrome and obesity. Phosphatidylcholines 27-46 toll like receptor 4 Homo sapiens 85-105 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 81-101 phospholipase A2, group IB, pancreas Mus musculus 110-126 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 81-101 lysophosphatidylcholine acyltransferase 1 Mus musculus 158-199 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 81-101 lysophosphatidylcholine acyltransferase 1 Mus musculus 201-207 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 38-40 phospholipase A2, group IB, pancreas Mus musculus 110-126 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 38-40 lysophosphatidylcholine acyltransferase 1 Mus musculus 158-199 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 38-40 lysophosphatidylcholine acyltransferase 1 Mus musculus 201-207 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 103-105 phospholipase A2, group IB, pancreas Mus musculus 110-126 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 103-105 lysophosphatidylcholine acyltransferase 1 Mus musculus 158-199 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 103-105 lysophosphatidylcholine acyltransferase 1 Mus musculus 201-207 27245897-1 2016 In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine. Phosphatidylcholines 230-249 bromodomain containing 2 Homo sapiens 19-36 27245897-1 2016 In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine. Phosphatidylcholines 230-249 bromodomain containing 2 Homo sapiens 38-41 30191692-2 2016 SGMS1 gene encodes an essential enzyme which is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide, wich determines its participation in the regulation of intracellular vesicular transport, cholesterol metabolism, cell proliferation, apoptosis and other significant processes. Phosphatidylcholines 115-134 sphingomyelin synthase 1 Homo sapiens 0-5 26505974-8 2015 Replenishing luminal phosphatidylcholine and taurocholate (n = 9) only enhanced apoA-V secretion in bile, suggesting that the increase was not due to depletion of phospholipids or bile salts. Phosphatidylcholines 21-40 apolipoprotein A5 Rattus norvegicus 80-86 26417903-0 2015 Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Phosphatidylcholines 126-145 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 0-38 26417903-0 2015 Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Phosphatidylcholines 126-145 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 40-46 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 142-161 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 163-165 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). Phosphatidylcholines 163-165 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26390854-8 2015 In addition, dietary restriction in aged worms resulting from sarcopenia of the pharyngeal pump likely decreases the abundance of SAMS-1, possibly leading to decreased phosphatidylcholine levels, larger lipid droplets, and ER and mitochondrial stress. Phosphatidylcholines 168-187 putative S-adenosylmethionine synthase 1 Caenorhabditis elegans 130-136 26438561-5 2015 We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). Phosphatidylcholines 140-159 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 14-24 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidylcholines 220-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidylcholines 220-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-56 26438561-5 2015 We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). Phosphatidylcholines 161-163 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 14-24 26503172-2 2015 Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis. Phosphatidylcholines 72-91 choline kinase alpha Homo sapiens 0-14 26503172-2 2015 Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis. Phosphatidylcholines 72-91 choline kinase alpha Homo sapiens 16-19 26503172-2 2015 Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis. Phosphatidylcholines 93-99 choline kinase alpha Homo sapiens 0-14 26503172-2 2015 Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis. Phosphatidylcholines 93-99 choline kinase alpha Homo sapiens 16-19 27022467-8 2015 DGAT1 inhibition leads to enhancement of carbon flow to the synthesis of phosphatidylcholine within the intestine. Phosphatidylcholines 73-92 diacylglycerol O-acyltransferase 1 Mus musculus 0-5 25790072-6 2015 The levels of plastid-synthesized lipids, mono- and di-galactosyldiacylglycerol and phosphatidylglycerol were reduced more in senescence-induced LEC2 than in endoplasmic reticulum-synthesized lipids, including phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol. Phosphatidylcholines 210-229 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 145-149 26226572-2 2015 The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function. Phosphatidylcholines 162-165 lysophosphatidylcholine acyltransferase 3 Mus musculus 33-72 26438722-3 2015 Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3. Phosphatidylcholines 135-154 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 185-189 26438722-3 2015 Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3. Phosphatidylcholines 135-154 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 194-198 26552767-5 2015 RESULTS: From six female and six male cats PEMT activity was assayed directly in liver biopsies taken before and after spaying/neutering, and assessed indirectly by analyses of PEMT-specific hepatic phosphatidylcholine (PC) species and plasma choline levels. Phosphatidylcholines 199-218 phosphatidylethanolamine N-methyltransferase Felis catus 177-181 26275961-7 2015 Furthermore, we demonstrate that clustered LD in fld1 or ldb16 mutants are transformed to SLD if phosphatidylcholine synthesis is compromised by additional deletion of the phosphatidylethanolamine methyltransferase, Cho2. Phosphatidylcholines 97-116 seipin Saccharomyces cerevisiae S288C 49-53 26275961-7 2015 Furthermore, we demonstrate that clustered LD in fld1 or ldb16 mutants are transformed to SLD if phosphatidylcholine synthesis is compromised by additional deletion of the phosphatidylethanolamine methyltransferase, Cho2. Phosphatidylcholines 97-116 Ldb16p Saccharomyces cerevisiae S288C 57-62 26226572-2 2015 The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function. Phosphatidylcholines 162-165 lysophosphatidylcholine acyltransferase 3 Mus musculus 74-79 26226572-12 2015 Oral administration of PC and olive oil allowed the LPCAT3 KO mice to survive with the same body weights as controls, but the KO mice had shorter and wider small-intestinal villi and longer and bigger small intestines. Phosphatidylcholines 23-25 lysophosphatidylcholine acyltransferase 3 Mus musculus 52-58 26474149-3 2015 Here, we observed that a high positive curvature of lipid vesicles with diameters of ~30 nm enhanced the association of Abeta with anionic phosphatidylglycerol membranes in the liquid-crystalline phase and with zwitterionic phosphatidylcholine membranes in the gel phase. Phosphatidylcholines 224-243 amyloid beta precursor protein Homo sapiens 120-125 26277750-1 2015 Classical lipases are well known for being enzymes hydrolysing triacylglycerols as substrate, except the porcine pancreatic lipase (PPL) which was able to hydrolyze phosphatidylcholine. Phosphatidylcholines 165-184 pancreatic triacylglycerol lipase Meleagris gallopavo 113-130 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. Phosphatidylcholines 53-72 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 0-5 26218418-6 2015 SUMMARY: A growing body of work demonstrates that nutrients present in high-fat foods (phosphatidylcholine, choline and L-carnitine) can be metabolized by the gut microbial enzymes to generate trimethylamine, which is then further metabolized by the host enzyme FMO3 to produce proatherogenic TMAO. Phosphatidylcholines 87-106 flavin containing monooxygenase 3 Mus musculus 262-266 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. Phosphatidylcholines 53-72 acyl-CoA binding domain containing 6 Homo sapiens 10-15 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. Phosphatidylcholines 74-76 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 0-5 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. Phosphatidylcholines 74-76 acyl-CoA binding domain containing 6 Homo sapiens 10-15 26290611-8 2015 The acylation rate of lysophosphatidylcholine into PC catalyzed by the red cell lysophosphatidylcholine-acyltransferase 1 protein was limited by the transfer of the acyl-CoA substrate from ACBD6 to the acyltransferase enzyme. Phosphatidylcholines 51-53 lysophosphatidylcholine acyltransferase 1 Homo sapiens 80-121 26290611-8 2015 The acylation rate of lysophosphatidylcholine into PC catalyzed by the red cell lysophosphatidylcholine-acyltransferase 1 protein was limited by the transfer of the acyl-CoA substrate from ACBD6 to the acyltransferase enzyme. Phosphatidylcholines 51-53 acyl-CoA binding domain containing 6 Homo sapiens 189-194 26841664-8 2015 The higher is ratio cholesterol alcohol/phosphatidylcholines in mono-layer of lipoproteins of very low density the slower is lipolysis, formation of ligand lipoproteins of very low density and their absorption by cells under apoB-100-endocytosis. Phosphatidylcholines 40-60 apolipoprotein B Homo sapiens 225-233 26108622-0 2015 Nuclear-localized CTP:phosphocholine cytidylyltransferase alpha regulates phosphatidylcholine synthesis required for lipid droplet biogenesis. Phosphatidylcholines 74-93 phosphate cytidylyltransferase 1A, choline Homo sapiens 18-63 26212548-11 2015 Gene expression analysis further showed decreased expression of PC biosynthetic genes choline kinase a and b, which further accelerated conversion of lysophosphatidylcholine to phosphatidylcholines through increasing the expression of lysophosphatidylcholine acyltransferase 3. Phosphatidylcholines 177-197 lysophosphatidylcholine acyltransferase 3 Homo sapiens 235-276 26208694-5 2015 Our group and others have further demonstrated that circulating TMAO levels are elevated in patients with type 2 diabetes mellitus compared to healthy controls and gut microbiota-dependent phosphatidylcholine metabolism has been implicated in metabolic dysregulation and insulin resistance in animal models. Phosphatidylcholines 189-208 insulin Homo sapiens 271-278 26260533-2 2015 Lysophosphatidylcholine acyltransferase (LPCAT) is a critical phospholipid biosynthesis enzyme, which promotes the conversion of lysophosphatidylcholine into phosphatidylcholine in the remodeling pathway of PC biosynthesis. Phosphatidylcholines 4-23 lysophosphatidylcholine acyltransferase 1 Homo sapiens 41-46 26568975-3 2015 Topologies are provided for four phosphatidylcholines: saturated DPPC, mono-cis unsaturated POPC and DOPC, and mono-trans unsaturated PEPC. Phosphatidylcholines 33-53 peptidase C Homo sapiens 134-138 26402860-1 2015 PURPOSE: The role of phosphatidylcholine-specific phospholipase C (PC-PLC), the enzyme involved in cell differentiation and proliferation, has not yet been explored in tumor initiating cells (TICs). Phosphatidylcholines 21-40 heparan sulfate proteoglycan 2 Homo sapiens 70-73 26295742-7 2015 Phosphatidylcholine and phosphatidylethanolamine (PE) demonstrated the largest consumption of mass during thrombin stimulation. Phosphatidylcholines 0-19 coagulation factor II, thrombin Homo sapiens 106-114 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 144-174 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 176-180 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 181-186 26322888-12 2015 The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p< 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity. Phosphatidylcholines 4-23 phosphatidylethanolamine N-methyltransferase Mus musculus 128-170 26322888-12 2015 The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p< 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity. Phosphatidylcholines 4-23 phosphatidylethanolamine N-methyltransferase Mus musculus 172-176 26322888-12 2015 The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p< 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity. Phosphatidylcholines 25-27 phosphatidylethanolamine N-methyltransferase Mus musculus 128-170 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 129-148 phosphate cytidylyltransferase 1A, choline Homo sapiens 77-85 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 129-148 cut like homeobox 1 Homo sapiens 161-164 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 150-152 phosphate cytidylyltransferase 1A, choline Homo sapiens 30-75 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 150-152 phosphate cytidylyltransferase 1A, choline Homo sapiens 77-85 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 150-152 cut like homeobox 1 Homo sapiens 161-164 26108622-2 2015 Based on results with insect CCT homologues, translocation of nuclear CCTalpha onto cytoplasmic lipid droplets (LDs) is proposed to stimulate the synthesis of PC that is required for LD biogenesis and triacylglycerol (TAG) storage. Phosphatidylcholines 159-161 phosphate cytidylyltransferase 1A, choline Homo sapiens 70-78 26108622-10 2015 We conclude that CCTalpha increases PC synthesis for LD biogenesis by translocation to the nuclear envelope and not cytoplasmic LDs. Phosphatidylcholines 36-38 phosphate cytidylyltransferase 1A, choline Homo sapiens 17-25 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 129-148 phosphate cytidylyltransferase 1A, choline Homo sapiens 30-75 25409201-4 2015 We demonstrate that oxidized phospholipids accumulate within alveolar macrophages (AMs) after bleomycin injury and that murine and human AMs treated with oxidized phosphatidylcholine (oxPc) become polarized along an M2 phenotype and display enhanced production of transforming growth factor-beta1. Phosphatidylcholines 163-182 transforming growth factor beta 1 Homo sapiens 264-296 26056930-5 2015 The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains. Phosphatidylcholines 102-121 phospholipase A2 group X Homo sapiens 25-30 26056930-5 2015 The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains. Phosphatidylcholines 123-125 phospholipase A2 group X Homo sapiens 25-30 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. Phosphatidylcholines 231-233 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 82-87 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. Phosphatidylcholines 231-233 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 88-93 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. Phosphatidylcholines 231-233 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 98-103 26265748-6 2015 Moreover, PLIN4 mRNA expression levels in muscle correlated with the expression of genes involved in de novo phospholipid biosynthesis, with muscular content of phosphatidylethanolamine and phosphatidylcholine, and with the content of subsarcolemmal lipid droplets. Phosphatidylcholines 190-209 perilipin 4 Homo sapiens 10-15 25767038-9 2015 In contrast, a phase separation was distinguished for both PC mixtures by ESR and XRD, indicative that PDPC and POPC mixtures differed in micron vs nano domain organization. Phosphatidylcholines 59-61 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 103-107 25841322-3 2015 These experiments revealed a significant decrease in levels of docosahexaenoic acid (DHA)-containing phosphatidylcholines (PCs), such as PC (diacyl-16:0/22:6), PC (diacyl-18:0/22:6), and PC (diacyl-18:1/22:6) in the L5 anterior horns of terminal stage (22-week-old) SOD1(G93A) mice. Phosphatidylcholines 123-126 superoxide dismutase 1, soluble Mus musculus 266-270 26307845-3 2015 Studies have confirmed that surface-active phospholipids (SAPLs), predominantly phosphatidylcholines (PCs), are responsible for the lubricating properties of lubricin in joints. Phosphatidylcholines 80-100 proteoglycan 4 Rattus norvegicus 158-166 26307845-3 2015 Studies have confirmed that surface-active phospholipids (SAPLs), predominantly phosphatidylcholines (PCs), are responsible for the lubricating properties of lubricin in joints. Phosphatidylcholines 102-105 proteoglycan 4 Rattus norvegicus 158-166 26122953-7 2015 The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid. Phosphatidylcholines 116-135 phosphatidylglycerophosphate synthase 1 Homo sapiens 22-61 26122953-7 2015 The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid. Phosphatidylcholines 116-135 phosphatidylglycerophosphate synthase 1 Homo sapiens 63-67 26122953-7 2015 The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid. Phosphatidylcholines 137-139 phosphatidylglycerophosphate synthase 1 Homo sapiens 22-61 26122953-7 2015 The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid. Phosphatidylcholines 137-139 phosphatidylglycerophosphate synthase 1 Homo sapiens 63-67 26122953-8 2015 PGS1 overexpression also elevated the mitochondrial contents of CL and PC, but had no effect on the number of mitochondria per cell. Phosphatidylcholines 71-73 phosphatidylglycerophosphate synthase 1 Homo sapiens 0-4 26120503-1 2015 INTRODUCTION: Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol. Phosphatidylcholines 63-82 endothelin receptor type A Homo sapiens 167-170 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 26120503-1 2015 INTRODUCTION: Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol. Phosphatidylcholines 63-82 diacylglycerol kinase eta Homo sapiens 172-176 26120503-2 2015 This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms receiving supplementation of phosphatidylcholine, and a genetic study of a risk variant of DGKH gene was performed in an attempt to provide an explanation for the potential beneficial effect of phosphatidylcholine supplementation. Phosphatidylcholines 117-136 diacylglycerol kinase eta Homo sapiens 179-183 26120503-2 2015 This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms receiving supplementation of phosphatidylcholine, and a genetic study of a risk variant of DGKH gene was performed in an attempt to provide an explanation for the potential beneficial effect of phosphatidylcholine supplementation. Phosphatidylcholines 282-301 diacylglycerol kinase eta Homo sapiens 179-183 26120503-9 2015 CONCLUSIONS: This study illustrated that a 16-year-old boy with hypomania symptoms responded well to supplementation of phosphatidylcholine and the boy carries a risk genotype in DGKH gene for bipolar disorder, which provides a possible explanation for the boy"s beneficial effect at the genetic level. Phosphatidylcholines 120-139 diacylglycerol kinase eta Homo sapiens 179-183 25944098-10 2015 The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues. Phosphatidylcholines 170-172 aminoalcoholphosphotransferase 1 Arabidopsis thaliana 19-24 25783052-2 2015 The aim of this study was to evaluate the hepatoprotective effects of PC against carbon tetrachloride (CCl4), which is a well-known hepatotoxicant that causes extensive oxidative liver damage, and to investigate the mechanisms involved in this protective effect. Phosphatidylcholines 70-72 chemokine (C-C motif) ligand 4 Mus musculus 103-107 25783052-5 2015 Histopathological evaluation of the liver also revealed that PC effectively ameliorated CCl4-induced hepatic injury and fibrosis. Phosphatidylcholines 61-63 chemokine (C-C motif) ligand 4 Mus musculus 88-92 25783052-6 2015 In addition, PC significantly counteracted the increase in glutathione levels and glutathione-S-transferase activity induced by CCl4. Phosphatidylcholines 13-15 chemokine (C-C motif) ligand 4 Mus musculus 128-132 25783052-8 2015 These results suggest that PC exerts its protective effects against CCl4-induced hepatotoxicity via its activities as an anti-oxidant and free radical scavenger. Phosphatidylcholines 27-29 chemokine (C-C motif) ligand 4 Mus musculus 68-72 25524654-6 2015 Relative increases in lysophosphatidylcholines and unsaturated phosphatidylcholines (PCs) were also observed in wire-injured ApoE-/- carotid arteries. Phosphatidylcholines 85-88 apolipoprotein E Mus musculus 125-129 25944098-1 2015 Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells. Phosphatidylcholines 65-84 aminoalcoholphosphotransferase Arabidopsis thaliana 0-30 25944098-1 2015 Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells. Phosphatidylcholines 65-84 aminoalcoholphosphotransferase Arabidopsis thaliana 32-36 25944098-1 2015 Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells. Phosphatidylcholines 86-88 aminoalcoholphosphotransferase Arabidopsis thaliana 0-30 25944098-10 2015 The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues. Phosphatidylcholines 170-172 aminoalcoholphosphotransferase 1 Arabidopsis thaliana 133-138 25944098-1 2015 Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells. Phosphatidylcholines 86-88 aminoalcoholphosphotransferase Arabidopsis thaliana 32-36 25944098-10 2015 The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues. Phosphatidylcholines 170-172 aminoalcoholphosphotransferase Arabidopsis thaliana 161-166 25667315-0 2015 A small phospholipase A2-alpha from castor catalyzes the removal of hydroxy fatty acids from phosphatidylcholine in transgenic Arabidopsis seeds. Phosphatidylcholines 93-112 phospholipase A 2A Arabidopsis thaliana 8-30 25433161-1 2015 BACKGROUND & AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine biosynthesis. Phosphatidylcholines 155-174 phosphatidylethanolamine N-methyltransferase Mus musculus 23-67 25433161-1 2015 BACKGROUND & AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine biosynthesis. Phosphatidylcholines 155-174 phosphatidylethanolamine N-methyltransferase Mus musculus 69-73 25604091-0 2015 Remodeling of host phosphatidylcholine by Chlamydia acyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets. Phosphatidylcholines 19-38 acyl-CoA binding domain containing 6 Homo sapiens 109-114 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 109-128 Lipin family protein Arabidopsis thaliana 42-77 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 109-128 Lipin family protein Arabidopsis thaliana 79-83 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 109-128 phosphatidic acid phosphohydrolase 2 Arabidopsis thaliana 89-93 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 130-132 Lipin family protein Arabidopsis thaliana 42-77 25670729-10 2015 These findings support the hypothesis that differences in the ability to take up blood phosphatidylcholine from low-density lipoproteins play an important role in early lactation metabolic stability of dairy cows and indicate APOBR to contain a causative variant. Phosphatidylcholines 87-106 apolipoprotein B receptor Bos taurus 226-231 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 130-132 Lipin family protein Arabidopsis thaliana 79-83 25862304-2 2015 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Phosphatidylcholines 130-132 phosphatidic acid phosphohydrolase 2 Arabidopsis thaliana 89-93 25803864-1 2015 BACKGROUND: The relevance of lysophosphatidylcholine acyltransferase1 (LPCAT1), a cytosolic enzyme in the remodeling pathway of phosphatidylcholine metabolism, in oral squamous cell carcinoma (OSCC) is unknown. Phosphatidylcholines 33-52 lysophosphatidylcholine acyltransferase 1 Homo sapiens 71-77 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 20-22 Lipin family protein Arabidopsis thaliana 26-30 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 20-22 phosphatidic acid phosphohydrolase 2 Arabidopsis thaliana 31-35 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 20-22 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 67-107 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 20-22 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 109-113 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 173-175 Lipin family protein Arabidopsis thaliana 26-30 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 173-175 phosphatidic acid phosphohydrolase 2 Arabidopsis thaliana 31-35 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 173-175 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 67-107 25862304-4 2015 The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis. Phosphatidylcholines 173-175 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 109-113 25862304-8 2015 Our data establish that membrane homeostasis is regulated by lipid composition in Arabidopsis and reveal a mechanism through which the abundance of PA, mediated by PAH activity, modulates CCT activity to govern PC content. Phosphatidylcholines 211-213 RNA polymerase II transcription mediator Arabidopsis thaliana 188-191 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 182-201 mechanistic target of rapamycin kinase Homo sapiens 29-33 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 182-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-151 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 182-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 25601960-0 2015 ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. Phosphatidylcholines 14-33 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25497764-4 2015 To reveal the reason for this discrepancy, we have examined the effect of Abeta on the fluidity of phosphatidylcholine membranes using spectroscopic methods. Phosphatidylcholines 99-118 amyloid beta precursor protein Homo sapiens 74-79 25497764-5 2015 The fluorescence anisotropy of DPH is dramatically increased on addition of Abeta to DPH-containing phosphatidylcholine membranes. Phosphatidylcholines 100-119 amyloid beta precursor protein Homo sapiens 76-81 25497764-8 2015 The observed CD bands of DPH are induced by a chiral environment of Abeta but not by that of the lipids, because positive CD bands appear regardless of the d/l-chirality of phosphatidylcholine. Phosphatidylcholines 173-192 amyloid beta precursor protein Homo sapiens 68-73 25601960-1 2015 ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Phosphatidylcholines 91-110 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25601960-1 2015 ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Phosphatidylcholines 112-114 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25601960-7 2015 ABCB4 must have evolved to exert its maximum activity in the SM-rich membrane environment of the canalicular membrane, where it transports PC as the physiological substrate. Phosphatidylcholines 139-141 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25259654-2 2015 This study aims to investigate the regulatory effects of the activity of UGT isoforms by two important lipid components phosphatidylcholine (PC) and lysophosphatidylcholines (LPC) using in vitro incubation system. Phosphatidylcholines 120-139 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 73-76 26065260-1 2015 Sphingomyelin synthase 1 (SMS1) is an enzyme of vital importance which is responsible for the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells. Phosphatidylcholines 145-164 sphingomyelin synthase 1 Homo sapiens 0-24 26065260-1 2015 Sphingomyelin synthase 1 (SMS1) is an enzyme of vital importance which is responsible for the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells. Phosphatidylcholines 145-164 sphingomyelin synthase 1 Homo sapiens 26-30 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 82-101 phosphatidylethanolamine N-methyltransferase Homo sapiens 113-117 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 82-101 betaine--homocysteine S-methyltransferase Homo sapiens 122-126 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 164-168 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 solute carrier family 22 member 1 Homo sapiens 66-70 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 solute carrier family 44 member 1 Homo sapiens 75-79 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 phosphatidylethanolamine N-methyltransferase Homo sapiens 113-117 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 betaine--homocysteine S-methyltransferase Homo sapiens 122-126 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 ATP binding cassette subfamily B member 4 Homo sapiens 164-168 25259654-2 2015 This study aims to investigate the regulatory effects of the activity of UGT isoforms by two important lipid components phosphatidylcholine (PC) and lysophosphatidylcholines (LPC) using in vitro incubation system. Phosphatidylcholines 141-143 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 73-76 25500141-7 2015 Inhibition of ACSL4 also prevented the large increase in PUFA-TAGs in HSCs upon activation and to a lesser extent the increase of arachidonate-containing phosphatidylcholine species. Phosphatidylcholines 154-173 acyl-CoA synthetase long chain family member 4 Homo sapiens 14-19 25533467-5 2015 The ATPase activity of wild type MDR3 was stimulated 2-fold by liver PC or 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine lipids. Phosphatidylcholines 69-71 ATP binding cassette subfamily B member 4 Homo sapiens 33-37 25650664-5 2015 Tumor cell death in vivo translating into liver tumor regression was associated with augmented phosphatidylcholine synthesis by the PEMT pathway, known as a liver-specific tumor suppressor, and restored mitochondrial function and TCA cycle flux. Phosphatidylcholines 95-114 phosphatidylethanolamine N-methyltransferase Homo sapiens 132-136 25173835-7 2015 An immunohistochemical examination revealed significantly worse disease-free and overall survival rates in patients with MDR3-negative HCC, in which the intratumoral accumulation of some phosphatidylcholine species was observed under imaging mass spectrometry. Phosphatidylcholines 187-206 ATP binding cassette subfamily B member 4 Homo sapiens 121-125 25140391-7 2015 PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-2 choline kinase alpha Mus musculus 58-72 25140391-7 2015 PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-2 choline kinase alpha Mus musculus 74-78 25140391-7 2015 PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-2 phosphatidylethanolamine N-methyltransferase Mus musculus 122-171 25140391-7 2015 PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-2 phosphatidylethanolamine N-methyltransferase Mus musculus 173-177 25519895-7 2015 Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes. Phosphatidylcholines 77-96 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 27-31 25519895-7 2015 Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes. Phosphatidylcholines 77-96 Atg7p Saccharomyces cerevisiae S288C 115-119 25519895-7 2015 Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes. Phosphatidylcholines 98-100 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 27-31 25519904-1 2015 Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined. Phosphatidylcholines 81-100 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 21-53 25519904-1 2015 Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined. Phosphatidylcholines 81-100 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 55-60 25519904-1 2015 Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined. Phosphatidylcholines 102-104 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 21-53 25519904-1 2015 Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined. Phosphatidylcholines 102-104 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 55-60 25380220-0 2015 Modeling and optimization of phospholipase A1-catalyzed hydrolysis of phosphatidylcholine using response surface methodology for lysophosphatidylcholine production. Phosphatidylcholines 70-89 lipase H Homo sapiens 29-45 25451916-3 2015 Here, we identify choline kinase beta (CHKB), a kinase involved in the biosynthesis of phosphatidylcholine, as a novel regulator of bone homeostasis. Phosphatidylcholines 87-106 choline kinase beta Mus musculus 18-37 25451916-3 2015 Here, we identify choline kinase beta (CHKB), a kinase involved in the biosynthesis of phosphatidylcholine, as a novel regulator of bone homeostasis. Phosphatidylcholines 87-106 choline kinase beta Mus musculus 39-43 25406316-3 2015 Several studies have suggested that Abeta peptides also bind to phosphatidylcholine membranes, which lead to deformation of membranes and fibrillation of Abeta. Phosphatidylcholines 64-83 amyloid beta precursor protein Homo sapiens 36-41 25406316-3 2015 Several studies have suggested that Abeta peptides also bind to phosphatidylcholine membranes, which lead to deformation of membranes and fibrillation of Abeta. Phosphatidylcholines 64-83 amyloid beta precursor protein Homo sapiens 154-159 24796972-6 2015 Lipidomics analysis identified seven lipid markers including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins and ceramides that were significantly decreased in serum of HFD-fed CYP7A1-tg mice. Phosphatidylcholines 65-85 cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus 192-198 25579789-0 2015 Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1. Phosphatidylcholines 63-82 ATP binding cassette subfamily A member 1 Homo sapiens 96-101 25380220-1 2015 Modeling the phospholipase A1 (PLA1 )-catalyzed partial hydrolysis of soy phosphatidylcholine (PC) in hexane for the production of lysophosphatidylcholine (LPC) and optimizing the reaction conditions using response surface methodology were described. Phosphatidylcholines 95-97 lipase H Homo sapiens 13-29 25380220-1 2015 Modeling the phospholipase A1 (PLA1 )-catalyzed partial hydrolysis of soy phosphatidylcholine (PC) in hexane for the production of lysophosphatidylcholine (LPC) and optimizing the reaction conditions using response surface methodology were described. Phosphatidylcholines 95-97 lipase H Homo sapiens 31-35 26125130-5 2015 In this study, we show that the wild-type mice display a rhythmic accumulation of hepatic phosphatidylcholine with a peak at ZT 22-0 while clock-deficient Bmal1(-/-) mice show elevated phosphatidylcholine levels in the liver associated with an atherogenic lipoprotein profile. Phosphatidylcholines 185-204 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 155-160 30154994-3 2015 Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. Phosphatidylcholines 177-196 cytochrome c, somatic Homo sapiens 41-46 30154994-6 2015 Based on these results, we postulate that the rise of H2O2 concentrations to the submillimolar levels registered during initiation of the apoptotic program may represent one signaling event that triggers the gain in peroxidatic function of the Cyt-c molecules bound to the abundant PE and PC membrane components. Phosphatidylcholines 289-291 cytochrome c, somatic Homo sapiens 244-249 30154994-3 2015 Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. Phosphatidylcholines 198-200 cytochrome c, somatic Homo sapiens 41-46 26125130-6 2015 Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1). Phosphatidylcholines 159-178 choline kinase alpha Mus musculus 219-227 26125130-12 2015 Collectively, these data establish that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis and suggest that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism. Phosphatidylcholines 48-67 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 114-119 26125130-6 2015 Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1). Phosphatidylcholines 159-178 choline kinase beta Mus musculus 267-274 26125130-12 2015 Collectively, these data establish that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis and suggest that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism. Phosphatidylcholines 48-67 choline kinase alpha Mus musculus 133-141 26125130-6 2015 Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1). Phosphatidylcholines 159-178 phosphatidylethanolamine N-methyltransferase Mus musculus 279-283 26125130-6 2015 Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1). Phosphatidylcholines 159-178 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 299-307 26125130-6 2015 Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1). Phosphatidylcholines 159-178 choline phosphotransferase 1 Mus musculus 312-317 25742922-12 2015 Although it was suggested that cholesterol esterase accelerated esterification of cholesterol incorporated into intestinal cells and acted as a transporter at the surface of intestinal cells, our research revealed that the accelerated cholesterol absorption was caused by hydrolysis of phosphatidylcholine in bile salt micelles. Phosphatidylcholines 286-305 carboxyl ester lipase Rattus norvegicus 31-51 25472447-1 2015 BACKGROUND: Choline kinase alpha (ChoKalpha) is a critical enzyme in the synthesis of phosphatidylcholine, a major structural component of eukaryotic cell membranes. Phosphatidylcholines 86-105 choline kinase alpha Homo sapiens 12-32 26042209-0 2015 Phosphatidylcholine-Mediated Aqueous Diffusion of Cellular Cholesterol Down-Regulates the ABCA1 Transporter in Human Skin Fibroblasts. Phosphatidylcholines 0-19 ATP binding cassette subfamily A member 1 Homo sapiens 90-95 26042209-14 2015 CONCLUSION: Thus, phosphatidylcholine facilitates removal of cellular cholesterol, thereby negating the cholesterol-dependent induction of ABCA1 message, protein and function. Phosphatidylcholines 18-37 ATP binding cassette subfamily A member 1 Homo sapiens 139-144 25281863-5 2015 Moreover, ASMase modulates alterations of the methionine cycle and phosphatidylcholine homeostasis, two crucial events involved in SH that regulate methylation reactions, antioxidant defence and membrane integrity. Phosphatidylcholines 67-86 sphingomyelin phosphodiesterase 1 Homo sapiens 10-16 24594635-1 2015 OBJECTIVE: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a potentially lethal autosomal recessive liver disease associated with mutations in ABCB4, the gene encoding the canalicular translocator of phosphatidylcholine MDR3. Phosphatidylcholines 216-235 ATP binding cassette subfamily B member 4 Homo sapiens 159-164 24594635-5 2015 ABCB4 missense mutations were phenotyped in vitro by assessing their effects on MDR3 expression, subcellular localisation, and phosphatidylcholine-translocating activity. Phosphatidylcholines 127-146 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 24594635-9 2015 Phosphatidylcholine efflux assays indicated that T201M, P479L, S978P and E1118K mutations impaired MDR3 activity to variable degrees. Phosphatidylcholines 0-19 ATP binding cassette subfamily B member 4 Homo sapiens 99-103 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 26274505-1 2015 The human sphingomyelin synthase 1 gene (SGMS1) encodes an essential enzyme that is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide. Phosphatidylcholines 151-170 sphingomyelin synthase 1 Homo sapiens 10-34 26274505-1 2015 The human sphingomyelin synthase 1 gene (SGMS1) encodes an essential enzyme that is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide. Phosphatidylcholines 151-170 sphingomyelin synthase 1 Homo sapiens 41-46 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. Phosphatidylcholines 171-190 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 57-61 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. Phosphatidylcholines 171-190 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 63-67 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. Phosphatidylcholines 171-190 aminophospholipid-translocating P4-type ATPase DNF3 Saccharomyces cerevisiae S288C 69-73 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. Phosphatidylcholines 171-190 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 75-79 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. Phosphatidylcholines 171-190 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 85-89 25671705-4 2015 CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 224-243 tropomyosin 3 Homo sapiens 7-11 25671705-4 2015 CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Phosphatidylcholines 245-247 tropomyosin 3 Homo sapiens 7-11 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25281910-5 2014 Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 16-21 25201589-6 2014 Three of six structural mutations influence cholesteryl ester and phosphatidylcholine binding by CETP. Phosphatidylcholines 66-85 cholesteryl ester transfer protein Homo sapiens 97-101 25281910-5 2014 Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 26-31 25223608-5 2014 Recombinant SPLUNC1 produced in HEK 293 cells harbored several molecular species of sphingomyelin and phosphatidylcholine as its ligands. Phosphatidylcholines 102-121 BPI fold containing family A member 1 Homo sapiens 12-19 25339683-12 2014 Besides SM, ASM also cleaves liposomal phosphatidylcholine. Phosphatidylcholines 39-58 sphingomyelin phosphodiesterase 1 Homo sapiens 12-15 25490414-1 2014 Phospholipase A2 (PLA2) changes the phosphatidylcholine contained in low-density lipoprotein (LDL) to lysophosphatidylcholine (LPC), which has various proatherogenic properties. Phosphatidylcholines 36-55 phospholipase A2 group IB Homo sapiens 0-16 25490414-1 2014 Phospholipase A2 (PLA2) changes the phosphatidylcholine contained in low-density lipoprotein (LDL) to lysophosphatidylcholine (LPC), which has various proatherogenic properties. Phosphatidylcholines 36-55 phospholipase A2 group IB Homo sapiens 18-22 25339683-13 2014 Anionic phospholipids derived from the plasma membrane (phosphatidylglycerol and phosphatidic acid) stimulate SM and phosphatidylcholine hydrolysis by ASM more effectively than BMP, which is generated during endocytosis. Phosphatidylcholines 117-136 sphingomyelin phosphodiesterase 1 Homo sapiens 151-154 25319916-1 2014 OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1. Phosphatidylcholines 15-34 phospholipase A2 group IB Rattus norvegicus 97-113 25339664-4 2014 Loss of ABCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholipids, including 1-palmitoyl-2-(5"-oxovaleroyl)-sn-glycero-3-phosphocholine, in the lungs. Phosphatidylcholines 66-86 ATP binding cassette subfamily G member 1 Mus musculus 8-13 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 150-169 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 22-27 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 150-169 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 32-37 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 150-169 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 38-43 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 171-173 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 22-27 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 171-173 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 32-37 25315773-2 2014 The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively. Phosphatidylcholines 171-173 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 38-43 25315773-5 2014 We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin. Phosphatidylcholines 120-122 ATPase phospholipid transporting 11A Homo sapiens 14-20 25315773-5 2014 We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin. Phosphatidylcholines 120-122 ATPase phospholipid transporting 11C Homo sapiens 25-31 25255925-6 2014 RESULTS: Reelin interacted with the liposomes containing phosphatidylserine (PS) or phosphatidylcholine. Phosphatidylcholines 84-103 reelin Mus musculus 9-15 25544413-1 2014 ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25544413-1 2014 ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 4 Homo sapiens 14-18 25396754-8 2014 Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives. Phosphatidylcholines 176-195 E2F transcription factor 2 Mus musculus 71-75 25396754-8 2014 Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives. Phosphatidylcholines 176-195 E2F transcription factor 2 Mus musculus 125-129 25258318-0 2014 Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. Phosphatidylcholines 133-152 serine/threonine protein kinase YPK1 Saccharomyces cerevisiae S288C 8-12 25258318-2 2014 We now report that Ypk1 also impacts the turnover of the major phospholipid, phosphatidylcholine (PC). Phosphatidylcholines 77-96 serine/threonine protein kinase YPK1 Saccharomyces cerevisiae S288C 19-23 25258318-2 2014 We now report that Ypk1 also impacts the turnover of the major phospholipid, phosphatidylcholine (PC). Phosphatidylcholines 98-100 serine/threonine protein kinase YPK1 Saccharomyces cerevisiae S288C 19-23 25258318-4 2014 Deletion of PLB1, a gene encoding a B-type phospholipase that hydrolyzes PC, in a ypk1Delta mutant curtails the increased PC deacylation. Phosphatidylcholines 73-75 lysophospholipase Saccharomyces cerevisiae S288C 12-16 25258318-4 2014 Deletion of PLB1, a gene encoding a B-type phospholipase that hydrolyzes PC, in a ypk1Delta mutant curtails the increased PC deacylation. Phosphatidylcholines 122-124 lysophospholipase Saccharomyces cerevisiae S288C 12-16 25258318-8 2014 Because Plb1 lacks a consensus phosphorylation site for Ypk1, we probed other processes under the control of Ypk1 that might be linked to PC turnover. Phosphatidylcholines 138-140 serine/threonine protein kinase YPK1 Saccharomyces cerevisiae S288C 109-113 25319916-1 2014 OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1. Phosphatidylcholines 15-34 lysophosphatidylcholine acyltransferase 1 Rattus norvegicus 164-205 25319916-1 2014 OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1. Phosphatidylcholines 74-93 phospholipase A2 group IB Rattus norvegicus 97-113 25319916-1 2014 OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1. Phosphatidylcholines 74-93 lysophosphatidylcholine acyltransferase 1 Rattus norvegicus 164-205 25091896-0 2014 Human carotid plaque phosphatidylcholine specifically interacts with paraoxonase 1, increases its activity, and enhances its uptake by macrophage at the expense of its binding to HDL. Phosphatidylcholines 21-40 paraoxonase 1 Homo sapiens 69-82 24992464-2 2014 PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum. Phosphatidylcholines 23-42 phosphatidylserine synthase 1 Homo sapiens 152-181 25193995-3 2014 In the Hint1(-/-) mice, serum total and esterified cholesterol were reduced 2.5-fold, and lysophosphatidylcholines (LPCs) and lysophosphatidic acids were 10-fold elevated in serum, with a corresponding fall in phosphatidylcholines (PCs). Phosphatidylcholines 94-114 histidine triad nucleotide binding protein 1 Mus musculus 7-12 25218477-5 2014 Silencing of IDH1 expression using siRNA in astrocytes isolated from E18.5 mouse cortices led to increased incorporation of [(3)H]-palmitate into the phosphatidylcholines (PCs) and decreased the incorporation of [(3)H]-palmitate into sphingomyelin and the phosphatidylethanolamines (PEs). Phosphatidylcholines 150-170 isocitrate dehydrogenase 1 (NADP+), soluble Mus musculus 13-17 25218477-5 2014 Silencing of IDH1 expression using siRNA in astrocytes isolated from E18.5 mouse cortices led to increased incorporation of [(3)H]-palmitate into the phosphatidylcholines (PCs) and decreased the incorporation of [(3)H]-palmitate into sphingomyelin and the phosphatidylethanolamines (PEs). Phosphatidylcholines 172-175 isocitrate dehydrogenase 1 (NADP+), soluble Mus musculus 13-17 24963152-5 2014 Adult offspring (both Ts65Dn and 2N) of choline-supplemented (vs. choline-unsupplemented) dams exhibited 60% greater (P<=0.007) activity of hepatic PEMT, which functions in de novo choline synthesis and produces phosphatidylcholine (PC) enriched in docosahexaenoic acid. Phosphatidylcholines 215-234 phosphatidylethanolamine N-methyltransferase Mus musculus 151-155 24963152-5 2014 Adult offspring (both Ts65Dn and 2N) of choline-supplemented (vs. choline-unsupplemented) dams exhibited 60% greater (P<=0.007) activity of hepatic PEMT, which functions in de novo choline synthesis and produces phosphatidylcholine (PC) enriched in docosahexaenoic acid. Phosphatidylcholines 236-238 phosphatidylethanolamine N-methyltransferase Mus musculus 151-155 25069533-1 2014 BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly. Phosphatidylcholines 81-100 protein C receptor, endothelial Mus musculus 12-42 25069533-1 2014 BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly. Phosphatidylcholines 81-100 protein C receptor, endothelial Mus musculus 44-48 25069533-1 2014 BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly. Phosphatidylcholines 45-47 protein C receptor, endothelial Mus musculus 12-42 25069533-2 2014 PC can be replaced with other lipids, such as lysophosphatidylcholine or platelet-activating factor, by the action of group V secretory phospholipase A2 (sPLA2-V), an enzyme that is upregulated in a variety of inflammatory conditions. Phosphatidylcholines 0-2 phospholipase A2, group V Mus musculus 154-159 24810251-8 2014 Furthermore, UPF1 up-regulated the contents of phospholipid species identified as phosphatidylcholines and phosphatidylethanolamines in the CSC-exposed HBECs, indicating possible suppression of inflammatory processes along with an increase in spermidine as an endogenous cytoprotector. Phosphatidylcholines 82-102 UPF1 RNA helicase and ATPase Homo sapiens 13-17 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 0-69 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 71-76 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 91-113 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 115-119 24992464-2 2014 PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum. Phosphatidylcholines 23-42 phosphatidylserine synthase 2 Homo sapiens 186-215 25205869-4 2014 Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities. Phosphatidylcholines 69-88 lipase C, hepatic type Homo sapiens 24-26 25205869-4 2014 Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities. Phosphatidylcholines 69-88 carboxyl ester lipase Homo sapiens 31-33 25205869-4 2014 Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities. Phosphatidylcholines 69-88 phospholipase A and acyltransferase 1 Homo sapiens 131-146 25103814-3 2014 We have analyzed SERCA crystal structures in the presence of four different phosphatidylcholine lipids of different lengths and double-bond compositions, and we find three different binding sites for lipid head groups, which are apparently independent of the acyl moiety of the lipids used. Phosphatidylcholines 76-95 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 17-22 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 24832487-4 2014 The expression of mitopmt suppressed the choline auxotrophy of a double deletion mutant of PEM1 and PEM2 (pem1Deltapem2Delta) and enabled it to synthesize PC in the absence of choline. Phosphatidylcholines 155-157 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 91-95 24832487-4 2014 The expression of mitopmt suppressed the choline auxotrophy of a double deletion mutant of PEM1 and PEM2 (pem1Deltapem2Delta) and enabled it to synthesize PC in the absence of choline. Phosphatidylcholines 155-157 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 100-104 24832487-6 2014 The pem1Deltapem2Delta strain deleted for PSD1 encoding the mitochondrial phosphatidylserine decarboxylase was able to grow because of the expression of mitopmt in the presence of ethanolamine, implying that PE from other organelles, probably from the ER, was converted to PC by mitopmt. Phosphatidylcholines 273-275 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 4-22 24832487-6 2014 The pem1Deltapem2Delta strain deleted for PSD1 encoding the mitochondrial phosphatidylserine decarboxylase was able to grow because of the expression of mitopmt in the presence of ethanolamine, implying that PE from other organelles, probably from the ER, was converted to PC by mitopmt. Phosphatidylcholines 273-275 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 42-46 24677714-1 2014 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver. Phosphatidylcholines 84-103 phosphatidylethanolamine N-methyltransferase Mus musculus 0-49 25118676-11 2014 The anticoagulant potency of Nk-PLA2beta which is higher than that of Nk-PLA2alpha is corroborated by its superior catalytic activity, its higher capacity for binding to phosphatidylcholine, and its greater strength of thrombin inhibition. Phosphatidylcholines 170-189 phospholipase A2 group IIA Homo sapiens 32-40 25170810-1 2014 This paper presents the synthesis of structured phosphatidylcholine (PC) enriched with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) by transesterification of DHA/EPA-rich ethyl esters with PC using immobilized phospholipsase A1 (PLA1) in solvent-free medium. Phosphatidylcholines 48-67 POU class 2 homeobox 3 Homo sapiens 243-247 25170810-1 2014 This paper presents the synthesis of structured phosphatidylcholine (PC) enriched with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) by transesterification of DHA/EPA-rich ethyl esters with PC using immobilized phospholipsase A1 (PLA1) in solvent-free medium. Phosphatidylcholines 69-71 POU class 2 homeobox 3 Homo sapiens 243-247 25170810-3 2014 Secondly, the immobilized PLA1 was used to catalyze transesterification of PC and DHA/EPA-rich ethyl esters. Phosphatidylcholines 75-77 POU class 2 homeobox 3 Homo sapiens 26-30 25157578-10 2014 The changes in pattern of phosphocholine and phosphatidylcholine in milk through lactation observed in the bovine suggests that it is possible to manufacture infant formula that more closely matches these metabolites profile in human milk. Phosphatidylcholines 45-64 Weaning weight-maternal milk Bos taurus 68-72 24677714-1 2014 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver. Phosphatidylcholines 84-103 phosphatidylethanolamine N-methyltransferase Mus musculus 51-55 24677714-1 2014 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver. Phosphatidylcholines 105-107 phosphatidylethanolamine N-methyltransferase Mus musculus 0-49 24677714-1 2014 Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver. Phosphatidylcholines 105-107 phosphatidylethanolamine N-methyltransferase Mus musculus 51-55 24677714-6 2014 Mitochondrial PC levels were lower and PE levels were higher in livers from Pemt(-/-) compared with Pemt(+/+) mice, resulting in a 33% reduction of the PC-to-PE ratio. Phosphatidylcholines 14-16 phosphatidylethanolamine N-methyltransferase Mus musculus 76-80 24677714-6 2014 Mitochondrial PC levels were lower and PE levels were higher in livers from Pemt(-/-) compared with Pemt(+/+) mice, resulting in a 33% reduction of the PC-to-PE ratio. Phosphatidylcholines 152-154 phosphatidylethanolamine N-methyltransferase Mus musculus 76-80 24811005-3 2014 Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility. Phosphatidylcholines 90-109 phospholipase D1 Homo sapiens 0-16 24811005-3 2014 Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility. Phosphatidylcholines 90-109 phospholipase D1 Homo sapiens 18-22 24677714-10 2014 We observed a strong correlation between mitochondrial PC-to-PE ratio and cellular ATP levels in hepatoma cells that expressed various amounts of PEMT. Phosphatidylcholines 55-57 phosphatidylethanolamine N-methyltransferase Mus musculus 146-150 24723470-1 2014 UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Phosphatidylcholines 43-62 ATP binding cassette subfamily B member 4 Homo sapiens 16-21 24723470-1 2014 UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Phosphatidylcholines 64-66 ATP binding cassette subfamily B member 4 Homo sapiens 16-21 24723470-10 2014 ABCB4-mediated PC secretion was also increased by pharmacological activation of protein kinases A or C and decreased by inhibition of these kinases. Phosphatidylcholines 15-17 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 24723470-12 2014 CONCLUSION: We identified disease-associated variants of ABCB4 involved in the phosphorylation of its N-terminal domain and leading to decreased PC secretion. Phosphatidylcholines 145-147 ATP binding cassette subfamily B member 4 Homo sapiens 57-62 24637075-7 2014 In chondrocytes from Chkb(-/-) mice, phosphatidylcholine was slightly lower than in WT mice whereas the amount of phosphocholine was decreased by approximately 75%. Phosphatidylcholines 37-56 choline kinase beta Mus musculus 21-25 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidylcholines 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 24949573-9 2014 In summary, betaine and phosphatidylcholine could be regarded as sensitive biomarkers for the toxic responses of BFP. Phosphatidylcholines 24-43 ring finger protein 112 Rattus norvegicus 113-116 24835967-4 2014 Small-MFG milk contained more total polar lipids; however, the relative proportion of individual polar lipids did not differ with MFG size, with the exception of phosphatidylcholine, which was greater in small-MFG milk. Phosphatidylcholines 162-181 Weaning weight-maternal milk Bos taurus 214-218 24910243-4 2014 PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization. Phosphatidylcholines 18-37 phospholipase A2, group V Mus musculus 0-6 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 56-75 lysophosphatidylcholine acyltransferase 1 Mus musculus 93-100 24909405-5 2014 (15)N chemical shift solid-state NMR spectroscopy indicates that the hydrophobic domain of p24 as well as a designed sequence of 19 hydrophobic amino acid residues adopt transmembrane alignments in phosphatidylcholine membranes. Phosphatidylcholines 198-217 transmembrane p24 trafficking protein 2 Homo sapiens 91-94 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 56-75 lysophosphatidylcholine acyltransferase 2 Mus musculus 221-227 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 56-75 patchy fur Mus musculus 150-153 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 56-75 patchy fur Mus musculus 44-47 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 94-96 patchy fur Mus musculus 44-47 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 94-96 lysophosphatidylcholine acyltransferase 2 Mus musculus 221-227 24850807-3 2014 Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells. Phosphatidylcholines 94-96 patchy fur Mus musculus 150-153 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidylcholines 59-78 phospholipase D1 Homo sapiens 0-16 24983355-5 2014 Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids. Phosphatidylcholines 229-248 syntaxin 1A Homo sapiens 56-60 24983355-5 2014 Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids. Phosphatidylcholines 229-248 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 139-142 24983355-5 2014 Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids. Phosphatidylcholines 250-252 syntaxin 1A Homo sapiens 56-60 24983355-5 2014 Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids. Phosphatidylcholines 250-252 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 139-142 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidylcholines 59-78 phospholipase D1 Homo sapiens 18-22 24813107-1 2014 The phospholipases D (PLD1 and 2) are signaling enzymes that catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid, a lipid second messenger involved in cell proliferation, and choline, a precursor of acetylcholine (ACh). Phosphatidylcholines 88-107 phospholipase D1 Mus musculus 22-32 24889630-6 2014 Both patients also had lipodystrophy, severe insulin resistance, and diabetes, providing evidence for an additional and essential role for PCYT1A-generated PC in the normal function of white adipose tissue and insulin action. Phosphatidylcholines 139-141 insulin Homo sapiens 210-217 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 123-142 methionine adenosyltransferase I, alpha Mus musculus 180-186 24769283-10 2014 Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation. Phosphatidylcholines 102-121 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 58-62 24769283-10 2014 Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation. Phosphatidylcholines 102-121 choline kinase beta Rattus norvegicus 74-78 24769283-10 2014 Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation. Phosphatidylcholines 123-125 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 58-62 24769283-10 2014 Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation. Phosphatidylcholines 123-125 choline kinase beta Rattus norvegicus 74-78 24843123-4 2014 In the present study, we find that worms with mutated or depleted mdt-15 (mdt-15 worms) exhibit decreased membrane phospholipid desaturation, especially in phosphatidylcholine. Phosphatidylcholines 156-175 Mediator of RNA polymerase II transcription subunit 15 Caenorhabditis elegans 66-72 24843123-4 2014 In the present study, we find that worms with mutated or depleted mdt-15 (mdt-15 worms) exhibit decreased membrane phospholipid desaturation, especially in phosphatidylcholine. Phosphatidylcholines 156-175 Mediator of RNA polymerase II transcription subunit 15 Caenorhabditis elegans 74-80 24657456-0 2014 Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury. Phosphatidylcholines 91-110 interleukin 6 Mus musculus 12-16 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 methionine adenosyltransferase I, alpha Mus musculus 180-186 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 200-244 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 123-142 phosphatidylethanolamine N-methyltransferase Mus musculus 200-244 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 phosphatidylethanolamine N-methyltransferase Mus musculus 246-250 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 123-142 phosphatidylethanolamine N-methyltransferase Mus musculus 246-250 24556610-2 2014 It has been shown that the overexpression of ACYL-COENZYME A-BINDING PROTEIN6 (ACBP6) resulted in enhanced freezing tolerance in seedlings and rosettes accompanied by a decrease in phosphatidylcholine (PC), an increase in phosphatidic acid (PA) and an up-regulation of PHOSPHOLIPASE Ddelta(PLDdelta) in the absence of COLD-RESPONSIVE (COR)-related gene induction. Phosphatidylcholines 202-204 acyl-CoA-binding protein 6 Arabidopsis thaliana 45-77 24717363-10 2014 Women with higher fasting concentrations of leucine and isoleucine and lower fasting concentrations of sphingomyelins and phosphatidylcholines had higher insulin responses despite similar glucose concentration after all kinds of bread (cross-validated ANOVA, P = 0.048). Phosphatidylcholines 122-142 insulin Homo sapiens 154-161 24583375-3 2014 Our results show that the CDP-choline pathway is the only de novo route for PC biosynthesis in both HOB and MG-63 cells. Phosphatidylcholines 76-78 cut like homeobox 1 Homo sapiens 26-29 24556610-2 2014 It has been shown that the overexpression of ACYL-COENZYME A-BINDING PROTEIN6 (ACBP6) resulted in enhanced freezing tolerance in seedlings and rosettes accompanied by a decrease in phosphatidylcholine (PC), an increase in phosphatidic acid (PA) and an up-regulation of PHOSPHOLIPASE Ddelta(PLDdelta) in the absence of COLD-RESPONSIVE (COR)-related gene induction. Phosphatidylcholines 202-204 acyl-CoA-binding protein 6 Arabidopsis thaliana 79-84 24806754-1 2014 UNLABELLED: ABCB4 flops phosphatidylcholine into the bile canaliculus to protect the biliary tree from the detergent activity of bile salts. Phosphatidylcholines 24-43 ATP binding cassette subfamily B member 4 Homo sapiens 12-17 24480410-4 2014 Association of Hsp70 with phosphatidylcholine (PC) liposomes is weak, with insertion of its Trps into the bilayer hydrocarbon region. Phosphatidylcholines 26-45 heat shock protein family A (Hsp70) member 4 Homo sapiens 15-20 24480410-4 2014 Association of Hsp70 with phosphatidylcholine (PC) liposomes is weak, with insertion of its Trps into the bilayer hydrocarbon region. Phosphatidylcholines 47-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 15-20 24779728-0 2014 Formation of highly structured cubic micellar lipid nanoparticles of soy phosphatidylcholine and glycerol dioleate and their degradation by triacylglycerol lipase. Phosphatidylcholines 73-92 lipase C, hepatic type Homo sapiens 140-162 23845852-3 2014 In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide. Phosphatidylcholines 304-323 ceramide transporter 1 Homo sapiens 157-161 23845852-3 2014 In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide. Phosphatidylcholines 325-331 ceramide transporter 1 Homo sapiens 157-161 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidylcholines 88-107 phospholipase D1 Homo sapiens 48-64 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidylcholines 88-107 phospholipase D1 Homo sapiens 66-70 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidylcholines 109-115 phospholipase D1 Homo sapiens 48-64 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidylcholines 109-115 phospholipase D1 Homo sapiens 66-70 24045840-1 2014 The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile". Phosphatidylcholines 61-80 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 24045840-1 2014 The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile". Phosphatidylcholines 61-80 ATP binding cassette subfamily B member 4 Homo sapiens 27-31 25831888-4 2014 SMS1 enzyme, encoded by this gene, catalyzes the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide. Phosphatidylcholines 100-119 sphingomyelin synthase 1 Homo sapiens 0-4 24648496-3 2014 Mutants defective in MET regulon repression reveal that loss of Cho2, which is required for the methylation of phosphatidylethanolamine to produce phosphatidylcholine, leads to induction of the MET regulon. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 64-68 24560778-1 2014 CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Phosphatidylcholines 43-62 cut-like homeobox 1 Rattus norvegicus 0-3 25097470-8 2014 RESULTS: THE FOLLOWING PROFILE OF APL IGG OR IGM WAS OBTAINED FROM PATIENTS WITH LOS: cardiolipin 15/45, phosphatidic acid 41/45, phosphatidyl-choline 0/45, -ethanolamine 6/45, -glycerole 1/45 (patient with Lyme disease), -inositol 7/45, -serine 14/45, annexin V 34/45, beta2GPI 21/45, prothrombin 30/45. Phosphatidylcholines 130-150 coagulation factor II, thrombin Homo sapiens 286-297 24440820-4 2014 The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 97-103 choline kinase alpha Homo sapiens 137-141 24763383-1 2014 The C2 domain of PKCalpha (C2alpha) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine. Phosphatidylcholines 207-226 protein kinase C alpha Homo sapiens 17-25 24368210-3 2014 Based on a kinetic comparative study between various pancreatic lipase family members, we showed here that porcine pancreatic lipase (PPL), which was so far classified as "classical lipase", was able to hydrolyze phosphatidylcholine (PC). Phosphatidylcholines 213-232 pancreatic lipase Homo sapiens 53-70 24368210-3 2014 Based on a kinetic comparative study between various pancreatic lipase family members, we showed here that porcine pancreatic lipase (PPL), which was so far classified as "classical lipase", was able to hydrolyze phosphatidylcholine (PC). Phosphatidylcholines 213-232 pancreatic lipase Homo sapiens 115-132 24368210-5 2014 Molecular dynamics was applied to investigate PC binding modes within the catalytic cavity of PPL and human pancreatic lipase (HPL), aiming to explain the difference of specificity of these enzymes towards phospholipids. Phosphatidylcholines 46-48 pancreatic lipase Homo sapiens 108-125 24368210-5 2014 Molecular dynamics was applied to investigate PC binding modes within the catalytic cavity of PPL and human pancreatic lipase (HPL), aiming to explain the difference of specificity of these enzymes towards phospholipids. Phosphatidylcholines 46-48 galectin 1 Homo sapiens 127-130 24440820-4 2014 The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 97-103 choline kinase alpha Homo sapiens 151-176 24440820-4 2014 The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1A, choline Homo sapiens 193-199 24440820-4 2014 The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1A, choline Homo sapiens 213-264 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Phosphatidylcholines 114-133 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Phosphatidylcholines 114-133 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Phosphatidylcholines 135-137 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Phosphatidylcholines 135-137 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 24667182-2 2014 Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. Phosphatidylcholines 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 42-46 24122873-0 2014 Peroxisome proliferator-activated receptor alpha activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Phosphatidylcholines 182-201 peroxisome proliferator activated receptor alpha Homo sapiens 0-48 24491568-1 2014 A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively. Phosphatidylcholines 36-55 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 142-146 24491568-1 2014 A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively. Phosphatidylcholines 36-55 galactokinase Saccharomyces cerevisiae S288C 203-207 24491568-1 2014 A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively. Phosphatidylcholines 36-55 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 248-252 24491568-1 2014 A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively. Phosphatidylcholines 36-55 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 257-261 24491568-1 2014 A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively. Phosphatidylcholines 57-59 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 142-146 24484915-11 2014 There was increased generation of oxidized phosphatidylcholine, a marker of OS, in NOS3(-/-) female mice receiving DOX+TRZ compared with control mice. Phosphatidylcholines 43-62 nitric oxide synthase 3, endothelial cell Mus musculus 83-87 24333558-1 2014 The work introduces the quenching of silica coated Tb(III) complexes by merocyanine 540 (MC540) and copper ions as a tool to reveal the adsorption of phosphatidylcholine (PC) and phosphatidylserine (PS) at various PS:PC ratio onto silica nanoparticles doped with Tb(III) complex. Phosphatidylcholines 150-169 surfactant protein C Homo sapiens 214-219 24333558-2 2014 The binding of MC540 with PC-based bilayers and copper ions with PS-based ones are the basis of their use as organic and inorganic probes to sense PS:PC ratio in silica supported mixed bilayers. Phosphatidylcholines 26-28 surfactant protein C Homo sapiens 147-152 24357062-6 2014 Treatment with apolipoprotein A-I or reconstituted HDLs consisting of apolipoprotein A-I complexed with phosphatidylcholine 24 hours before and at days 1, 7, 9, and 11 after PG-PS administration reduced acute and chronic joint inflammation. Phosphatidylcholines 104-123 apolipoprotein A1 Rattus norvegicus 15-33 24357062-6 2014 Treatment with apolipoprotein A-I or reconstituted HDLs consisting of apolipoprotein A-I complexed with phosphatidylcholine 24 hours before and at days 1, 7, 9, and 11 after PG-PS administration reduced acute and chronic joint inflammation. Phosphatidylcholines 104-123 apolipoprotein A1 Rattus norvegicus 70-88 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 139-158 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 139-158 ATP binding cassette subfamily B member 4 Homo sapiens 95-100 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 160-162 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 160-162 ATP binding cassette subfamily B member 4 Homo sapiens 95-100 23894007-1 2014 BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology. Phosphatidylcholines 16-35 phospholipase A2 group IB Homo sapiens 98-114 24122814-1 2014 CSL112 is apoA-I purified from human plasma and reconstituted with phosphatidylcholine (PC) to form high-density lipoprotein (HDL)-particles suitable for infusion. Phosphatidylcholines 88-90 apolipoprotein A1 Homo sapiens 10-16 23894007-1 2014 BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology. Phosphatidylcholines 16-35 phospholipase A2 group IB Homo sapiens 116-120 23894007-1 2014 BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology. Phosphatidylcholines 38-40 phospholipase A2 group IB Homo sapiens 98-114 23894007-1 2014 BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology. Phosphatidylcholines 38-40 phospholipase A2 group IB Homo sapiens 116-120 23894007-7 2014 CONCLUSIONS: These data suggest that PLA2, which catalyzes the hydrolysis of PC to yield LPC and free fatty acid, is supposed to be an important etiological factor in BECs injury in pancreaticobiliary maljunction or intrahepatic cholelithiasis. Phosphatidylcholines 77-79 phospholipase A2 group IB Homo sapiens 37-41 24456402-0 2014 Monitoring phosphatidic acid formation in intact phosphatidylcholine bilayers upon phospholipase D catalysis. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 83-98 24368431-2 2014 In mammals, choline is synthesized via phosphatidylethanolamine N-methyltransferase (Pemt), which converts phosphatidylethanolamine to phosphatidylcholine. Phosphatidylcholines 135-154 phosphatidylethanolamine N-methyltransferase Mus musculus 85-89 24664753-4 2014 The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of VLC-PUFA in the retinal phosphatidylcholine (PC) fraction compared to retinas from wild-type mice. Phosphatidylcholines 111-130 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 Mus musculus 37-43 24578622-1 2014 BACKGROUND: CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator. Phosphatidylcholines 69-88 cut-like homeobox 1 Rattus norvegicus 12-15 24333423-7 2014 When the recombinant HAS2 proteins were reconstituted into liposomes composed of both saturated phosphatidylcholine and cholesterol, this provided a higher enzyme activity as compared with the liposomes formed by phosphatidylcholine alone. Phosphatidylcholines 96-115 hyaluronan synthase 2 Homo sapiens 21-25 24333423-7 2014 When the recombinant HAS2 proteins were reconstituted into liposomes composed of both saturated phosphatidylcholine and cholesterol, this provided a higher enzyme activity as compared with the liposomes formed by phosphatidylcholine alone. Phosphatidylcholines 213-232 hyaluronan synthase 2 Homo sapiens 21-25 24333423-8 2014 Cholesterol regulates HAS2 activity in a biphasic manner, depending on the molar ratio of phosphatidylcholine to cholesterol. Phosphatidylcholines 90-109 hyaluronan synthase 2 Homo sapiens 22-26 24176936-3 2014 The transcription factor Steroidogenic Factor-1 (SF-1) is an excellent model to address this question, as it forms dynamic complexes with several chemically distinct lipid species (phosphatidylinositols, phosphatidylcholines and sphingolipids). Phosphatidylcholines 204-224 splicing factor 1 Homo sapiens 25-53 23612856-1 2014 BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes. Phosphatidylcholines 205-224 solute carrier family 22 member 1 Homo sapiens 127-155 23612856-1 2014 BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes. Phosphatidylcholines 205-224 solute carrier family 22 member 1 Homo sapiens 157-161 23612856-1 2014 BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes. Phosphatidylcholines 205-224 solute carrier family 22 member 1 Homo sapiens 162-169 24387990-0 2014 Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy. Phosphatidylcholines 49-68 phosphate cytidylyltransferase 1A, choline Homo sapiens 13-19 23988655-3 2014 In addition, LC/MS lipidomics analysis of the CMOI-/- embryos showed reduced levels of four phosphatidylcholine and three phosphatidylethanolamine acyl chain species, and of eight triacylglycerol species with four or more unsaturations and fifty-two or more carbons in the acyl chains. Phosphatidylcholines 92-111 beta-carotene oxygenase 1 Mus musculus 46-50 24404395-1 2014 PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty acids. Phosphatidylcholines 157-176 phospholipase A2 group IB Homo sapiens 105-121 24404395-1 2014 PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty acids. Phosphatidylcholines 157-176 phospholipase A2 group IB Homo sapiens 123-127 24404396-3 2014 Furthermore, pathological lung conditions are associated with upregulated phospholipase A2 (PLA2), the predominant enzyme producing LPC in tissues by hydrolysis of phosphatidylcholine. Phosphatidylcholines 164-183 phospholipase A2 group IB Homo sapiens 74-90 24404396-3 2014 Furthermore, pathological lung conditions are associated with upregulated phospholipase A2 (PLA2), the predominant enzyme producing LPC in tissues by hydrolysis of phosphatidylcholine. Phosphatidylcholines 164-183 phospholipase A2 group IB Homo sapiens 92-96 24186874-8 2014 IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells. Phosphatidylcholines 84-103 interleukin 1 beta Mus musculus 0-8 24186874-8 2014 IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells. Phosphatidylcholines 84-103 interleukin 1 beta Mus musculus 215-223 24186874-8 2014 IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells. Phosphatidylcholines 147-166 interleukin 1 beta Mus musculus 0-8 24186874-8 2014 IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells. Phosphatidylcholines 147-166 interleukin 1 beta Mus musculus 215-223 24095834-6 2014 Electrospray ionization mass spectrometry of cellular phospholipids bearing AA showed that the levels of some, if not all, phosphatidylcholine (PC) and phosphatidylinositol species in Acsl4 knockdown cells were decreased after IL-1beta stimulation, while those in control cells were not so obviously decreased. Phosphatidylcholines 123-142 acyl-CoA synthetase long-chain family member 4 Rattus norvegicus 184-189 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25133187-6 2014 In the presence of bile salts, ABCB4 located in nonraft membranes mediates the efflux of phospholipids, preferentially phosphatidylcholine. Phosphatidylcholines 119-138 ATP binding cassette subfamily B member 4 Homo sapiens 31-36 24772432-5 2014 Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation. Phosphatidylcholines 13-15 mitogen-activated protein kinase kinase 7 Homo sapiens 68-71 24772432-5 2014 Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation. Phosphatidylcholines 13-15 mitogen-activated protein kinase 3 Homo sapiens 72-78 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 24062078-1 2013 Sphingomyelin synthase 1 (SMS1) is an essential enzyme that catalyses the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells. Phosphatidylcholines 125-144 sphingomyelin synthase 1 Homo sapiens 0-24 24292666-0 2014 Protective effect of phosphatidylcholine on restoration of ethanol-injured hepatocytes related with caveolin-1. Phosphatidylcholines 21-40 caveolin 1 Homo sapiens 100-110 24292666-9 2014 However, the levels of Caveolin-1 and PKC-alpha were increased by phosphatidylcholine administration. Phosphatidylcholines 66-85 caveolin 1 Homo sapiens 23-33 24204024-8 2014 Unexpectedly, in planta, E. coli CPS acts primarily on the sn-1 position of PC; coexpression of SfLPAT results in the incorporation of CPA at the sn-2 position of lysophosphatidic acid. Phosphatidylcholines 76-78 Terpenoid cyclases/Protein prenyltransferases superfamily protein Arabidopsis thaliana 33-36 24187140-0 2013 Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability. Phosphatidylcholines 37-56 Hnm1p Saccharomyces cerevisiae S288C 95-99 24292666-9 2014 However, the levels of Caveolin-1 and PKC-alpha were increased by phosphatidylcholine administration. Phosphatidylcholines 66-85 protein kinase C alpha Homo sapiens 38-47 24292666-10 2014 The results indicated that the inhibition of lipid peroxidation by phosphatidylcholine could lead to the prevention of membrane disruption, which closely correlated with the level of Caveolin-1. Phosphatidylcholines 67-86 caveolin 1 Homo sapiens 183-193 24292666-11 2014 Since the protective effects of phosphatidylcholine against ethanol-induced lipid peroxidation might be regulated by phospholipid-PKC-alpha signaling pathway, related with Caveolin-1, the potential effects of phosphatidylcholine on membranes need to be verified. Phosphatidylcholines 32-51 protein kinase C alpha Homo sapiens 130-139 24292666-11 2014 Since the protective effects of phosphatidylcholine against ethanol-induced lipid peroxidation might be regulated by phospholipid-PKC-alpha signaling pathway, related with Caveolin-1, the potential effects of phosphatidylcholine on membranes need to be verified. Phosphatidylcholines 32-51 caveolin 1 Homo sapiens 172-182 24251714-7 2013 Lysophosphatidylcholine (lysoPC), a derivative of phosphatidylcholine hydrolysis by phospholipase A2, is a highly abundant bioactive lipid mediator present in circulation as well as in bile. Phosphatidylcholines 4-23 phospholipase A2 group IB Homo sapiens 84-100 24062078-1 2013 Sphingomyelin synthase 1 (SMS1) is an essential enzyme that catalyses the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells. Phosphatidylcholines 125-144 sphingomyelin synthase 1 Homo sapiens 26-30 24097981-6 2013 ABCA1 actively exported or flipped phosphatidylcholine, phosphatidylserine, and sphingomyelin from the cytoplasmic to the exocytoplasmic leaflet of membranes, whereas ABCA7 preferentially exported phosphatidylserine. Phosphatidylcholines 35-54 ATP binding cassette subfamily A member 1 Homo sapiens 0-5 24205231-6 2013 Under fasting conditions, carriers of TCF7L2 rs7903146 exhibited a non-significant increase of plasma sphingomyelins (SMs), phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) species. Phosphatidylcholines 124-144 transcription factor 7 like 2 Homo sapiens 38-44 24287694-4 2013 Choline kinase alpha (ChoKalpha), the first enzyme in the Kennedy pathway, is responsible for the generation of phosphorylcholine (PCho) that ultimately renders phosphatidylcholine. Phosphatidylcholines 161-180 choline kinase alpha Homo sapiens 0-32 24279474-8 2013 Purified and re-folded active rPlp exhibited phospholipase A2 activity against phosphatidylcholine and no activity against phosphatidylserine, phosphatidylethanolamine, or sphingomyelin. Phosphatidylcholines 79-98 proteolipid protein 1 Rattus norvegicus 30-34 24279474-11 2013 Additionally, rPlp had strong hemolytic activity towards rainbow trout erythrocytes, but not to sheep erythrocytes suggesting that rPlp is optimized for lysis of phosphatidylcholine-rich fish erythrocytes. Phosphatidylcholines 162-181 proteolipid protein 1 Rattus norvegicus 14-18 24279474-11 2013 Additionally, rPlp had strong hemolytic activity towards rainbow trout erythrocytes, but not to sheep erythrocytes suggesting that rPlp is optimized for lysis of phosphatidylcholine-rich fish erythrocytes. Phosphatidylcholines 162-181 proteolipid protein 1 Rattus norvegicus 131-135 24279474-14 2013 CONCLUSION: The plp gene of V. anguillarum encoding a phospholipase with A2 activity is specific for phosphatidylcholine and, therefore, able to lyse fish erythrocytes, but not sheep erythrocytes. Phosphatidylcholines 101-120 proteolipid protein 1 Rattus norvegicus 16-19 24080101-2 2013 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 86-105 cut like homeobox 1 Homo sapiens 49-52 24080101-2 2013 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 107-109 cut like homeobox 1 Homo sapiens 49-52 24279474-0 2013 Characterization of Plp, a phosphatidylcholine-specific phospholipase and hemolysin of Vibrio anguillarum. Phosphatidylcholines 27-46 proteolipid protein 1 Rattus norvegicus 20-23 23963955-1 2013 Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine. Phosphatidylcholines 194-213 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-22 23963955-1 2013 Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine. Phosphatidylcholines 194-213 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 23963955-1 2013 Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine. Phosphatidylcholines 194-213 cytochrome p450 oxidoreductase Homo sapiens 102-105 24025327-2 2013 This was accomplished by studying the exposure of PMCA to surrounding phospholipids by measuring the incorporation of the photoactivatable phosphatidylcholine analog 1-O-hexadecanoyl-2-O-[9-[[[2-[(125)I]iodo-4-(trifluoromethyl-3H-diazirin-3-yl)benzyl]oxy]carbonyl]nonanoyl]-sn-glycero-3-phosphocholine to the protein. Phosphatidylcholines 139-158 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 50-54 24153306-8 2013 Unbiased metabolite profiling identifies phosphatidylcholine 18:0/18:1 (PC(18:0/18:1) as a serum lipid regulated by diurnal hepatic PPARdelta activity. Phosphatidylcholines 41-60 peroxisome proliferator activator receptor delta Mus musculus 132-141 24205231-6 2013 Under fasting conditions, carriers of TCF7L2 rs7903146 exhibited a non-significant increase of plasma sphingomyelins (SMs), phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) species. Phosphatidylcholines 146-149 transcription factor 7 like 2 Homo sapiens 38-44 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 75-94 glycine N-methyltransferase Mus musculus 206-210 23917775-2 2013 Here, we show that a systemic treatment of mice bearing skin tumors with empty phosphatidylcholine liposomes (PCL) resulted in inhibition of tumor growth, which was similar to that observed with the synthetic bacterial lipoprotein and TLR1/2 agonist Pam(3)CSK(4) (BLP). Phosphatidylcholines 79-98 gastrin releasing peptide Mus musculus 264-267 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 75-94 phosphatidylethanolamine N-methyltransferase Mus musculus 124-173 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 75-94 phosphatidylethanolamine N-methyltransferase Mus musculus 175-179 23945283-7 2013 SUMMARY: CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane. Phosphatidylcholines 107-126 choline kinase beta Homo sapiens 9-13 23945283-7 2013 SUMMARY: CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane. Phosphatidylcholines 107-126 choline kinase beta Homo sapiens 22-41 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 96-98 phosphatidylethanolamine N-methyltransferase Mus musculus 124-173 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 96-98 phosphatidylethanolamine N-methyltransferase Mus musculus 175-179 23505042-4 2013 We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice. Phosphatidylcholines 96-98 glycine N-methyltransferase Mus musculus 206-210 23505042-7 2013 We also observed that the flux from PE to PC is stimulated in the liver of Gnmt(-/-) mice and that this results in a reduction in PE content and a marked increase in DG and TG. Phosphatidylcholines 42-44 glycine N-methyltransferase Mus musculus 75-79 23505042-9 2013 Gnmt(-/-) mice with an additional deletion of perilipin2, the predominant lipid droplet protein, maintain high SAMe levels, with a concurrent increased flux from PE to PC, but do not develop liver steatosis. Phosphatidylcholines 168-170 glycine N-methyltransferase Mus musculus 0-4 23712050-8 2013 However, lipidomic analysis of the regenerating liver from Ldlr(-)(/)(-) revealed a lipid profile compatible with liver quiescence: high content of cholesterol esters and ceramide, and low levels of phosphatidylcholine. Phosphatidylcholines 199-218 low density lipoprotein receptor Mus musculus 59-63 23881110-4 2013 RESULTS: As compared with WT mice, unchallenged Abca3(+/-) mice had significantly decreased lung phosphatidylcholine (PC) and phosphatidylglycerol (PG) levels (P < 0.02) and decreased lung compliance (P < 0.05). Phosphatidylcholines 97-116 ATP-binding cassette, sub-family A (ABC1), member 3 Mus musculus 48-53 23872453-12 2013 The phthalocyanine-nitroimidazole conjugate, Pc-4 was encapsulated in phosphatidylglycerol:phosphatidylcholine unilamellar liposomes and subjected to photocytotoxicity study. Phosphatidylcholines 91-110 SUB1 regulator of transcription Homo sapiens 45-49 23881110-4 2013 RESULTS: As compared with WT mice, unchallenged Abca3(+/-) mice had significantly decreased lung phosphatidylcholine (PC) and phosphatidylglycerol (PG) levels (P < 0.02) and decreased lung compliance (P < 0.05). Phosphatidylcholines 118-120 ATP-binding cassette, sub-family A (ABC1), member 3 Mus musculus 48-53 23881110-7 2013 The ratio of PC to PG in BAL-relevant for surfactant dysfunction-was significantly elevated by oxygen exposure, with the greatest increase in Abca3(+/-) mice. Phosphatidylcholines 13-15 ATP-binding cassette, sub-family A (ABC1), member 3 Mus musculus 142-147 23897804-5 2013 Vitellogenin binds directly to phosphatidylcholine liposomes and with higher affinity to liposomes containing phosphatidylserine, a lipid of the inner leaflet of cell membranes that is exposed in damaged cells. Phosphatidylcholines 31-50 vitellogenin Apis mellifera 0-12 23872271-11 2013 COX activity was lower in pect1-4 mitochondria at 5 weeks, most probably due to reduced phosphatidylethanolamine levels and/or an altered phosphatidylethanolamine:phosphatidylcholine ratio. Phosphatidylcholines 163-182 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 26-31 23763823-3 2013 We found increased phosphatidylcholine and decreased ceramides in the brain of PGC1a-deficient mice. Phosphatidylcholines 19-38 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 79-84 24052074-0 2013 Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E-/-mice. Phosphatidylcholines 68-87 annexin A7 Mus musculus 10-20 24052074-1 2013 Phosphatidylcholine-specific phospholipase C (PC-PLC) is a key factor in apoptosis and autophagy of vascular endothelial cells (VECs), and involved in atherosclerosis in apolipoprotein E-/- (apoE-/-) mice. Phosphatidylcholines 0-19 apolipoprotein E Mus musculus 170-199 23850486-2 2013 Here, we showed that liposomes consisting of phosphatidylserine and lysophosphatidylcholine, a lipolysis product of phosphatidylcholine by PLA2, were phagocytosed by microglia, but failed to induce secretion of PGE2. Phosphatidylcholines 72-91 phospholipase A2 group IB Homo sapiens 139-143 23850486-5 2013 We thus hypothesize that free arachidonic acid is supplied through aiPLA2-mediated lipolysis of phagocytosed phosphatidylcholine, leading to the production of PGH2 and its downstream metabolites. Phosphatidylcholines 109-128 peroxiredoxin 6 Homo sapiens 67-73 23796515-3 2013 The dissociation constant of moesin FERM domain to CLS in the phosphatidylcholine liposome is about 300nM. Phosphatidylcholines 62-81 moesin Homo sapiens 29-35 23796515-4 2013 In contrast to disrupting the CaM association with CLS, inclusion of anionic phosphatidylserine lipids in the phosphatidylcholine liposome increased the apparent binding affinity of moesin FERM domain for CLS. Phosphatidylcholines 110-129 moesin Homo sapiens 182-188 23816424-9 2013 FASN inhibitor treated Y79 RB and fibroblast cells showed decrease in the cellular lipids (triglyceride, cholesterol and phosphatidyl choline) levels. Phosphatidylcholines 121-141 fatty acid synthase Homo sapiens 0-4 23639419-2 2013 Many reports exist on PLD-mediated synthesis of natural and tailor-made PLs with functional head groups, from easily available lecithin or phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 22-25 23763831-7 2013 Mt-I rapidly hydrolyzed phosphatidylcholine and phosphatidylethanolamine but not phosphatidylserine, but no phospho-lipids were hydrolyzed in the presence of Mt-II. Phosphatidylcholines 24-43 metallothionein 1 Mus musculus 0-4 23801329-11 2013 Phosphatidylcholine vesicles containing LacCer increased cPLA2alpha activity. Phosphatidylcholines 0-19 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 57-67 23931318-3 2013 Here, we determined the high-resolution structure of huntingtin 1-17 in dodecyl phosphocholine micelles and the topology of its helical domain in oriented phosphatidylcholine bilayers. Phosphatidylcholines 155-174 huntingtin Homo sapiens 53-63 23641021-5 2013 PC is mainly synthesized through the Kennedy pathway with choline kinase (ChoK) and CTP:phosphocholine cytidylyltranferase (CCT) as key regulatory enzymes. Phosphatidylcholines 0-2 choline kinase alpha Mus musculus 58-72 23135760-7 2013 ITF prebiotics also decreased Bacteroides intestinalis, Bacteroides vulgatus and Propionibacterium, an effect associated with a slight decrease in fat mass and with plasma lactate and phosphatidylcholine levels. Phosphatidylcholines 184-203 trefoil factor 3 Homo sapiens 0-3 23794138-6 2013 Using electrospray ionization-mass spectrometry, we identified the species of triacylglycerols and phosphatidylcholines that were hydrolyzed by LPL and EL, and we identified the fatty acids liberated by gas chromatography-mass spectrometry. Phosphatidylcholines 99-119 lipoprotein lipase Homo sapiens 144-147 23794138-6 2013 Using electrospray ionization-mass spectrometry, we identified the species of triacylglycerols and phosphatidylcholines that were hydrolyzed by LPL and EL, and we identified the fatty acids liberated by gas chromatography-mass spectrometry. Phosphatidylcholines 99-119 lipase G, endothelial type Homo sapiens 152-154 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 phosphatidylcholine transfer protein Mus musculus 47-52 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 phosphatidylcholine transfer protein Mus musculus 79-84 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 acyl-CoA thioesterase 13 Mus musculus 90-95 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 TSC complex subunit 2 Mus musculus 100-104 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 phosphatidylcholine transfer protein Mus musculus 79-84 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 acyl-CoA thioesterase 13 Mus musculus 134-139 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 insulin receptor substrate 2 Mus musculus 197-201 23901139-7 2013 Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1. Phosphatidylcholines 11-30 CREB regulated transcription coactivator 1 Mus musculus 206-212 23727005-0 2013 Synthesis of mixed-chain phosphatidylcholines including coumarin fluorophores for FRET-based kinetic studies of phospholipase A(2) enzymes. Phosphatidylcholines 25-45 phospholipase A2 group IB Homo sapiens 112-130 23727005-4 2013 Here we report a new synthesis of double-labeled phosphatidylcholine analogs with chain-terminal reporter groups including coumarin fluorophores for fluorescence resonance energy transfer (FRET)-based kinetic studies of PLA2 enzymes. Phosphatidylcholines 49-68 phospholipase A2 group IB Homo sapiens 220-224 23727005-8 2013 Specifically, the rate of PLA2 hydrolysis of the coumarin labeled phosphatidylcholine analogs was less than three times slower than the natural substrate dipalmitoyl phosphatidylcholine (DPPC) under the same experimental conditions. Phosphatidylcholines 66-85 phospholipase A2 group IB Homo sapiens 26-30 23564075-1 2013 The present study investigated the effects of DeltaPsi and DeltapH (pH gradient) on the interaction of cytochrome c with a mitochondrial mimetic membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) leading to vesicle fusion. Phosphatidylcholines 166-185 cytochrome c, somatic Homo sapiens 103-115 23564075-1 2013 The present study investigated the effects of DeltaPsi and DeltapH (pH gradient) on the interaction of cytochrome c with a mitochondrial mimetic membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) leading to vesicle fusion. Phosphatidylcholines 187-189 cytochrome c, somatic Homo sapiens 103-115 23811944-6 2013 The appearance of malignant changes correlated with a pronounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with activation of Akt and mTOR signaling that were attenuated by treatment with the mTOR inhibitor everolimus. Phosphatidylcholines 77-96 thymoma viral proto-oncogene 1 Mus musculus 171-174 23811944-6 2013 The appearance of malignant changes correlated with a pronounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with activation of Akt and mTOR signaling that were attenuated by treatment with the mTOR inhibitor everolimus. Phosphatidylcholines 77-96 mechanistic target of rapamycin kinase Mus musculus 237-241 23723068-3 2013 PLD catalyzes the hydrolysis of phosphatidylcholine into PA. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 23641021-5 2013 PC is mainly synthesized through the Kennedy pathway with choline kinase (ChoK) and CTP:phosphocholine cytidylyltranferase (CCT) as key regulatory enzymes. Phosphatidylcholines 0-2 choline kinase alpha Mus musculus 74-78 23700249-0 2013 Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes. Phosphatidylcholines 36-55 lysophospholipid acyltransferase 1 Ricinus communis 130-178 23228325-1 2013 BACKGROUND: Cytidine 5"-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine. Phosphatidylcholines 108-127 cut-like homeobox 1 Rattus norvegicus 42-45 23228325-10 2013 In addition, NEC damage reduced intestinal tissue membrane phospholipids, whereas CDP-choline significantly enhanced total phospholipid and phosphatidylcholine levels. Phosphatidylcholines 140-159 cut-like homeobox 1 Rattus norvegicus 82-85 23604781-2 2013 A model for delivering dietary sn-2-DHA phosphatidylcholine (PtdCho) to the brain involves phospholipase A2 based deacylation/reacylation cycle followed by delivery of DHA through high-density lipoproteins that bind to the brain capillary endothelial cells in the blood-brain barrier (BBB). Phosphatidylcholines 61-67 phospholipase A2 group IB Homo sapiens 91-107 23604781-6 2013 The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. Phosphatidylcholines 214-220 phospholipase A2 group IB Homo sapiens 57-61 23604781-6 2013 The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. Phosphatidylcholines 214-220 phospholipase A2 group IIA Homo sapiens 63-68 23604781-6 2013 The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. Phosphatidylcholines 214-220 lipase G, endothelial type Homo sapiens 181-183 23671037-7 2013 Furthermore, (13) C-fatty acid tracing studies indicate that compound K inhibition of DGAT1 increased the production of phosphatidyl choline (PC). Phosphatidylcholines 120-140 diacylglycerol O-acyltransferase 1 Mus musculus 86-91 23671037-7 2013 Furthermore, (13) C-fatty acid tracing studies indicate that compound K inhibition of DGAT1 increased the production of phosphatidyl choline (PC). Phosphatidylcholines 142-144 diacylglycerol O-acyltransferase 1 Mus musculus 86-91 23671037-9 2013 DGAT1 inhibition leads to enhanced PC production via alternative carbon channeling. Phosphatidylcholines 35-37 diacylglycerol O-acyltransferase 1 Mus musculus 0-5 23686420-4 2013 TAG accumulation in sdp1 roots requires both ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) and PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL ACYLTRANSFERASE1 and can also be strongly stimulated by the provision of exogenous sugar. Phosphatidylcholines 105-124 Patatin-like phospholipase family protein Arabidopsis thaliana 20-24 23700249-0 2013 Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes. Phosphatidylcholines 36-55 lysophospholipid acyltransferase 1 Ricinus communis 180-185 23700249-0 2013 Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes. Phosphatidylcholines 252-258 lysophospholipid acyltransferase 1 Ricinus communis 130-178 23762411-10 2013 Dramatic increases in phosphatidic acid (PA) and decreases in phosphatidylcholine (PC) during ABA-induced senescence were also suppressed in PLDdelta-KO plants. Phosphatidylcholines 62-81 phospholipase D delta Arabidopsis thaliana 141-149 23762411-10 2013 Dramatic increases in phosphatidic acid (PA) and decreases in phosphatidylcholine (PC) during ABA-induced senescence were also suppressed in PLDdelta-KO plants. Phosphatidylcholines 83-85 phospholipase D delta Arabidopsis thaliana 141-149 23501167-0 2013 Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p. Phosphatidylcholines 54-73 lysophospholipase Saccharomyces cerevisiae S288C 129-134 23501167-5 2013 The exchange of acyl chains occurred at both the sn-1 and sn-2 positions of the glycerol backbone of PC, and required the phospholipase B Plb1p for optimal efficiency. Phosphatidylcholines 101-103 lysophospholipase Saccharomyces cerevisiae S288C 138-143 23749897-5 2013 RESULTS: Sphingomyelin 34:1, phosphatidylcholine (PC) 32:0, and PC 34:1, and PC 36:2 were overexpressed in HER2-positive breast cancer compared to adjacent normal tissue (HER2 signature). Phosphatidylcholines 29-48 erb-b2 receptor tyrosine kinase 2 Homo sapiens 107-111 23474920-0 2013 Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2. Phosphatidylcholines 70-89 toll like receptor 4 Homo sapiens 15-35 23501167-6 2013 Sct1p-catalyzed acyl chain exchange, the acyl-CoA binding protein Acb1p, the Plb1p homologue Plb2p, and the glycerophospholipid:triacylglycerol transacylase Lro1p were not required for PC remodeling. Phosphatidylcholines 185-187 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 Saccharomyces cerevisiae S288C 0-5 23474920-0 2013 Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2. Phosphatidylcholines 70-89 lymphocyte antigen 96 Homo sapiens 129-132 23516040-2 2013 Data were analyzed with a new kinetic model of LCAT activity at interface that exploits the efficiency of LCAT binding to the particle, particle dimensions, and surface concentrations of phosphatidylcholine and cholesterol. Phosphatidylcholines 187-206 lecithin-cholesterol acyltransferase Homo sapiens 47-51 23776397-12 2013 The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine. Phosphatidylcholines 19-21 tumor necrosis factor Rattus norvegicus 101-110 23776397-12 2013 The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine. Phosphatidylcholines 19-21 interleukin 6 Rattus norvegicus 115-119 23776397-12 2013 The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine. Phosphatidylcholines 19-21 interleukin 10 Rattus norvegicus 214-219 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). Phosphatidylcholines 68-88 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 230-234 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). Phosphatidylcholines 68-88 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 239-243 23772401-1 2013 Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 4-23 phospholipase A2 group IB Rattus norvegicus 88-104 23772401-1 2013 Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 4-23 phospholipase A2 group IB Rattus norvegicus 106-110 23772401-1 2013 Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 26-28 phospholipase A2 group IB Rattus norvegicus 88-104 23772401-1 2013 Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC). Phosphatidylcholines 26-28 phospholipase A2 group IB Rattus norvegicus 106-110 23658780-4 2013 Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin) reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner. Phosphatidylcholines 262-281 calmodulin 1 Homo sapiens 61-71 23658780-4 2013 Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin) reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner. Phosphatidylcholines 262-281 selectin L Homo sapiens 229-239 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 16-36 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. Phosphatidylcholines 29-31 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. Phosphatidylcholines 147-149 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23456478-8 2013 Although a similar choline-phospholipid efflux is evoked by these apoA-I variants, the change in phosphatidylcholine/sphyngomyelin distribution produced by wild-type apoA-I is not observed with either K107 or K226. Phosphatidylcholines 97-116 apolipoprotein A-I Cricetulus griseus 166-172 23613812-0 2013 Human breast cancer tissues contain abundant phosphatidylcholine(36:1) with high stearoyl-CoA desaturase-1 expression. Phosphatidylcholines 45-64 stearoyl-CoA desaturase Homo sapiens 81-106 23519169-3 2013 Here, we show that plasma membrane (PM)--ER contact sites in yeast are required for phosphatidylcholine synthesis and regulate the activity of the phosphatidylethanolamine N-methyltransferase enzyme, Opi3. Phosphatidylcholines 84-103 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 200-204 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidylcholines 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidylcholines 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 38-41 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 11 Homo sapiens 79-83 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 11 Homo sapiens 84-90 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 100-130 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 132-136 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 137-142 23446897-1 2013 BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). Phosphatidylcholines 12-31 phosphatidylethanolamine N-methyltransferase Homo sapiens 136-140 23446897-1 2013 BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). Phosphatidylcholines 33-35 phosphatidylethanolamine N-methyltransferase Homo sapiens 136-140 23271056-4 2013 Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels. Phosphatidylcholines 86-105 apolipoprotein A1 Homo sapiens 121-127 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 4 Homo sapiens 24-28 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 1 Homo sapiens 209-213 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 4 Homo sapiens 277-281 23271056-4 2013 Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels. Phosphatidylcholines 86-105 C-C motif chemokine ligand 2 Homo sapiens 189-193 23271056-4 2013 Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels. Phosphatidylcholines 86-105 C-C motif chemokine ligand 5 Homo sapiens 201-205 23271056-4 2013 Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels. Phosphatidylcholines 86-105 C-X3-C motif chemokine ligand 1 Homo sapiens 217-223 23585650-5 2013 Lipid profiling revealed that 34C species of phosphatidylglycerol (PG) and monogalactosyl diacylglycerol (MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, lyso-phosphatidylcholine, and phosphatidylserine were higher than the wild type. Phosphatidylcholines 218-237 16:0delta9 desaturase 2 Arabidopsis thaliana 123-127 23349207-2 2013 The overall shape of both particles is discoidal with the low-resolution structure of apoA1 visualized as an open, contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl phosphatidylcholine without cholesterol (nHDL(DMPC)) and two arms in nascent HDL/dimyristoyl phosphatidylcholine with cholesterol (nHDL(DMPC+Chol)). Phosphatidylcholines 199-218 apolipoprotein A1 Homo sapiens 86-91 23448237-10 2013 As recombinant ACBP1 binds phosphatidic acid and phosphatidylcholine, ACBP1 probably promotes PLDalpha1 action. Phosphatidylcholines 49-68 acyl-CoA binding protein 1 Arabidopsis thaliana 15-20 23448237-10 2013 As recombinant ACBP1 binds phosphatidic acid and phosphatidylcholine, ACBP1 probably promotes PLDalpha1 action. Phosphatidylcholines 49-68 phospholipase D alpha 1 Arabidopsis thaliana 94-103 23369752-0 2013 GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine. Phosphatidylcholines 34-53 glycolipid transfer protein Homo sapiens 0-4 23369752-2 2013 Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction. Phosphatidylcholines 0-19 glycolipid transfer protein Homo sapiens 240-244 23369752-2 2013 Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction. Phosphatidylcholines 21-23 glycolipid transfer protein Homo sapiens 240-244 23349189-2 2013 Group X sPLA2 (PLA2G10) has the most potent hydrolyzing activity toward phosphatidylcholine and is believed to play a proatherogenic role. Phosphatidylcholines 72-91 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 8-13 23507753-4 2013 Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. Phosphatidylcholines 72-91 StAR related lipid transfer domain containing 7 Homo sapiens 29-35 23505262-0 2013 Retraction: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. Phosphatidylcholines 47-66 cut like homeobox 1 Homo sapiens 12-15 23505262-0 2013 Retraction: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. Phosphatidylcholines 47-66 phospholipase A2 group IB Homo sapiens 102-163 23537027-2 2013 Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation. Phosphatidylcholines 49-68 procollagen C-endopeptidase enhancer Homo sapiens 70-72 23537027-2 2013 Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation. Phosphatidylcholines 49-68 procollagen C-endopeptidase enhancer Homo sapiens 103-105 23349189-2 2013 Group X sPLA2 (PLA2G10) has the most potent hydrolyzing activity toward phosphatidylcholine and is believed to play a proatherogenic role. Phosphatidylcholines 72-91 phospholipase A2, group X Mus musculus 15-22 23269393-9 2013 The hypertonic upregulation of phosphatidylcholine (PC) synthesis, the main constituent of all cell membranes, involved the transcriptional activation of two main regulatory enzymes, choline kinase (CK) and cytidylyltransferase alpha (CCTalpha) and required ERK1/2 activation. Phosphatidylcholines 31-50 mitogen-activated protein kinase 1 Canis lupus familiaris 258-264 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 109-128 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 109-128 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 130-132 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 130-132 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 22903185-9 2013 NTE reduces levels of phosphatidylcholine (PtdCho) by degrading it to glycerophosphocholine and two free fatty acids. Phosphatidylcholines 22-41 patatin like phospholipase domain containing 6 Homo sapiens 0-3 22903185-9 2013 NTE reduces levels of phosphatidylcholine (PtdCho) by degrading it to glycerophosphocholine and two free fatty acids. Phosphatidylcholines 43-49 patatin like phospholipase domain containing 6 Homo sapiens 0-3 22903185-10 2013 The substrate for NTE may be nascent PtdCho complexed with a phospholipid-binding protein. Phosphatidylcholines 37-43 patatin like phospholipase domain containing 6 Homo sapiens 18-21 22903185-11 2013 Protein kinase A-mediated phosphorylation enhances PtdCho synthesis and may allow PtdCho accumulation by coordinate inhibition of NTE activity. Phosphatidylcholines 82-88 patatin like phospholipase domain containing 6 Homo sapiens 130-133 23277511-1 2013 Group IVA cytosolic phospholipase A2 (cPLA2alpha), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. Phosphatidylcholines 215-234 phospholipase A2 group IVA Homo sapiens 38-48 23010477-1 2013 The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 4-7 23010477-1 2013 The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Phosphatidylcholines 48-54 cut like homeobox 1 Homo sapiens 4-7 23010477-6 2013 Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Phosphatidylcholines 10-16 patatin like phospholipase domain containing 6 Homo sapiens 56-82 23010477-6 2013 Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Phosphatidylcholines 10-16 cut like homeobox 1 Homo sapiens 113-116 23262193-3 2013 We have recently shown that the C2 domain of MFG-E8 bears more specificity toward PS when compared with phosphatidylcholine (PC), another phospholipid thought to be involved in the immune function of phagocytes. Phosphatidylcholines 125-127 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 45-51 23266496-1 2013 Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. Phosphatidylcholines 75-94 cytochrome c, somatic Homo sapiens 20-32 23266496-1 2013 Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. Phosphatidylcholines 75-94 cytochrome c, somatic Homo sapiens 34-39 23266496-1 2013 Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. Phosphatidylcholines 96-98 cytochrome c, somatic Homo sapiens 20-32 23266496-1 2013 Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. Phosphatidylcholines 96-98 cytochrome c, somatic Homo sapiens 34-39 23269393-9 2013 The hypertonic upregulation of phosphatidylcholine (PC) synthesis, the main constituent of all cell membranes, involved the transcriptional activation of two main regulatory enzymes, choline kinase (CK) and cytidylyltransferase alpha (CCTalpha) and required ERK1/2 activation. Phosphatidylcholines 52-54 mitogen-activated protein kinase 1 Canis lupus familiaris 258-264 23044079-8 2013 In addition, the phosphatidylcholine/phosphatidylethanolamine liver ratio decrease was less important in TNF(-/-) mice. Phosphatidylcholines 17-36 tumor necrosis factor Mus musculus 105-108 23420493-1 2013 Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases. Phosphatidylcholines 118-137 phospholipase A2 group IID Homo sapiens 10-37 23200860-1 2013 STARD10, a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) protein family, is highly expressed in the liver and has been shown to transfer phosphatidylcholine. Phosphatidylcholines 182-201 START domain containing 10 Mus musculus 0-7 23032700-9 2013 These data indicate that cobalamin mediates down-regulation of Multidrug Resistance-1 gene expression through increased S-adenosyl-methionine and phosphatidylcholine productions and phospholipase D activation. Phosphatidylcholines 146-165 ATP binding cassette subfamily B member 1 Homo sapiens 63-85 23420493-1 2013 Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases. Phosphatidylcholines 118-137 phospholipase A2 group IID Homo sapiens 39-44 23420493-1 2013 Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases. Phosphatidylcholines 118-137 phospholipase A2 group IID Homo sapiens 47-52 22982257-3 2013 In this paper SLN were prepared using stearic acid as main lipid component, stearylamine as cationic agent and protamine as transfection promoter and adding phosphatidylcholine (PC), cholesterol (Chol) or both to obtain three different multicomponent SLN (SLN-PC, SLN-Chol and SLN-PC-Chol, respectively). Phosphatidylcholines 157-176 sarcolipin Homo sapiens 14-17 22982257-10 2013 Comparing these results to those obtained with the same kind of SLN without PC and/or Chol, it is possible to conclude that the addition of Chol and/or PC to the composition of cationic SLN modify the cell tolerance and the transfection efficiency of the gene vector in a manner strictly dependent on the cell type and the internalization pathways. Phosphatidylcholines 152-154 sarcolipin Homo sapiens 186-189 22982257-3 2013 In this paper SLN were prepared using stearic acid as main lipid component, stearylamine as cationic agent and protamine as transfection promoter and adding phosphatidylcholine (PC), cholesterol (Chol) or both to obtain three different multicomponent SLN (SLN-PC, SLN-Chol and SLN-PC-Chol, respectively). Phosphatidylcholines 178-180 sarcolipin Homo sapiens 14-17 23193974-7 2013 Furthermore, the phospholipid composition markedly influences P450 turnover and b(5) stimulation and specificity, particularly for CYP17A1, in the following order: phosphatidylserine > phosphatidylethanolamine > phosphatidylcholine. Phosphatidylcholines 218-237 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 131-138 23451176-4 2013 Immunohistochemistry of obese normal, SS and NASH liver specimens with anti-phosphatidylethanomine N-methyltransferase (PEMT) antibodies showed a progressive decrease in the zonal distribution of this PC biosynthetic enzyme. Phosphatidylcholines 201-203 phosphatidylethanolamine N-methyltransferase Homo sapiens 71-118 23074091-0 2013 Phosphatidylcholine enrichment with medium chain fatty acids by immobilized phospholipase A(1) -catalyzed acidolysis. Phosphatidylcholines 0-19 lipase H Homo sapiens 76-94 23074091-2 2013 In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568. Phosphatidylcholines 15-34 lipase H Homo sapiens 110-128 23074091-2 2013 In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568. Phosphatidylcholines 15-34 lipase H Homo sapiens 130-136 23074091-2 2013 In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568. Phosphatidylcholines 36-38 lipase H Homo sapiens 110-128 23074091-2 2013 In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568. Phosphatidylcholines 36-38 lipase H Homo sapiens 130-136 23746278-3 2013 When the phosphatidylcholine-polymer-coated peptide microarray was applied to the analysis of the kinome of HCC827 cells, hyperactivation of c-Src and EGFR were successfully detected. Phosphatidylcholines 9-28 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 141-146 23746278-3 2013 When the phosphatidylcholine-polymer-coated peptide microarray was applied to the analysis of the kinome of HCC827 cells, hyperactivation of c-Src and EGFR were successfully detected. Phosphatidylcholines 9-28 epidermal growth factor receptor Homo sapiens 151-155 23681536-5 2013 Here we provide four variations of in vitro PLD activity assays using choline-labeled phosphatidylcholine to distinguish, to the extent possible, among the different PLD classes. Phosphatidylcholines 86-105 phospholipase D alpha 1 Arabidopsis thaliana 44-47 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 C-C motif chemokine ligand 2 Homo sapiens 118-122 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 145-150 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 mitogen-activated protein kinase 3 Homo sapiens 179-185 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 phospholipase C beta 1 Homo sapiens 201-207 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 246-251 23155050-2 2013 As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation. Phosphatidylcholines 59-61 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 73-118 23155050-2 2013 As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation. Phosphatidylcholines 59-61 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 120-128 23452035-8 2013 Likewise, asthma risk alleles from the PDED3 and MED24 genes at the asthma susceptibility locus 17q21 were associated with increased concentrations of various phosphatidylcholines with consistent effect directions. Phosphatidylcholines 159-179 mediator complex subunit 24 Homo sapiens 49-54 24068966-2 2013 By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). Phosphatidylcholines 88-107 Progestin and AdipoQ Receptor family Caenorhabditis elegans 23-29 24068966-2 2013 By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). Phosphatidylcholines 88-107 Choline/EthanolaminePhosphoTransferase Caenorhabditis elegans 119-125 24068966-2 2013 By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). Phosphatidylcholines 88-107 CTP_transf_like domain-containing protein;Putative choline-phosphate cytidylyltransferase Caenorhabditis elegans 127-133 24068966-2 2013 By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). Phosphatidylcholines 88-107 putative S-adenosylmethionine synthase 1 Caenorhabditis elegans 138-144 23451176-4 2013 Immunohistochemistry of obese normal, SS and NASH liver specimens with anti-phosphatidylethanomine N-methyltransferase (PEMT) antibodies showed a progressive decrease in the zonal distribution of this PC biosynthetic enzyme. Phosphatidylcholines 201-203 phosphatidylethanolamine N-methyltransferase Homo sapiens 120-124 23043861-6 2012 Phosphatidylcholine vesicles containing C2-DE-C1P reduced cPLA(2)alpha activity in vitro. Phosphatidylcholines 0-19 phospholipase A2 group IVA Homo sapiens 58-70 24291895-2 2013 Based upon the similarity in the pathological features to rmd mouse which has a recessive mutation in Chkb gene encoding the choline kinase beta that catalyzes first enzymatic step in a biosynthetic pathway for phosphatidylcholine, we have sequenced the CHKB gene in 15 patients with the disease and identified identified biallelic mutations in all patients. Phosphatidylcholines 211-230 choline kinase beta Mus musculus 102-106 24291895-2 2013 Based upon the similarity in the pathological features to rmd mouse which has a recessive mutation in Chkb gene encoding the choline kinase beta that catalyzes first enzymatic step in a biosynthetic pathway for phosphatidylcholine, we have sequenced the CHKB gene in 15 patients with the disease and identified identified biallelic mutations in all patients. Phosphatidylcholines 211-230 choline kinase beta Mus musculus 125-144 22970809-2 2012 Although Ybt1p was originally identified as a bile acid transporter, it has also been found to function in other capacities, including the translocation of phosphatidylcholine to the vacuole lumen, and the regulation of Ca2+ homoeostasis. Phosphatidylcholines 156-175 bile acid-transporting ATPase YBT1 Saccharomyces cerevisiae S288C 9-14 23091059-6 2012 Both cholesterol and sphingomyelin were required for the formation of TCR dimers in phosphatidylcholine-containing large unilamellar vesicles. Phosphatidylcholines 84-103 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 70-73 22921758-3 2012 RVVA-PLA2-I preferentially hydrolyzed phospholipids (phosphatidylcholine) of erythrocyte membrane compared to the liver mitochondrial membrane. Phosphatidylcholines 53-72 phospholipase A2, group V Mus musculus 5-9 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 318-338 phospholipase A2 group VII Homo sapiens 19-60 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 318-338 phospholipase A2 group VII Homo sapiens 62-71 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 340-342 phospholipase A2 group VII Homo sapiens 19-60 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 340-342 phospholipase A2 group VII Homo sapiens 62-71 22921758-8 2012 Our study advocates that the presence of a large number of PLA2-sensitive phospholipid domains/composition, rather than only the phosphatidylcholine (PC) content of that particular membrane may determine the extent of membrane damage by a particular venom PLA2 enzyme. Phosphatidylcholines 129-148 phospholipase A2, group V Mus musculus 256-260 22888116-5 2012 Furthermore, phosphatidylcholine increased the binding affinity of the substrates to the CYP1B1. Phosphatidylcholines 13-32 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 89-95 23000394-0 2012 Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. Phosphatidylcholines 0-19 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 45-66 23000394-0 2012 Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. Phosphatidylcholines 0-19 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 68-73 23000394-0 2012 Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. Phosphatidylcholines 0-19 BTG anti-proliferation factor 2 Rattus norvegicus 96-123 22991194-2 2012 It is well established that cPLA(2)alpha binds zwitterionic lipids such as phosphatidylcholine in a Ca(2+)-dependent manner through its N-terminal C2 domain, which regulates its translocation to cellular membranes. Phosphatidylcholines 75-94 phospholipase A2 group IVA Homo sapiens 28-40 22988242-1 2012 CTP:phosphocholine cytidylyltransferase (CCT), an amphitropic enzyme that regulates phosphatidylcholine synthesis, is composed of a catalytic head domain and a regulatory tail. Phosphatidylcholines 84-103 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-39 22988242-1 2012 CTP:phosphocholine cytidylyltransferase (CCT), an amphitropic enzyme that regulates phosphatidylcholine synthesis, is composed of a catalytic head domain and a regulatory tail. Phosphatidylcholines 84-103 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 41-44 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidylcholines 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidylcholines 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22221492-5 2012 Compared to the control group, significant increases of DHA, EPA+DHA and total n-3 PUFA in plasma choline phosphoglyceride were observed in the three oily fish groups. Phosphatidylcholines 98-122 pumilio RNA binding family member 3 Homo sapiens 83-87 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23032920-5 2012 The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases. Phosphatidylcholines 13-33 amyloid beta precursor protein Rattus norvegicus 63-68 23032920-5 2012 The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases. Phosphatidylcholines 13-33 phospholipase A2 group IB Rattus norvegicus 146-164 23032920-5 2012 The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases. Phosphatidylcholines 35-38 amyloid beta precursor protein Rattus norvegicus 63-68 23032920-5 2012 The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases. Phosphatidylcholines 35-38 phospholipase A2 group IB Rattus norvegicus 146-164 23074967-2 2012 Cytidine triphosphate (CTP):phosphocholine cytidylyltransferase alpha (CTalpha) regulates the primary pathway of PC biosynthesis in the liver. Phosphatidylcholines 113-115 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 71-78 22743636-1 2012 Group V secretory phospholipase A2 (sPLA2-V) hydrolyzes phosphatidylcholine in low-density lipoprotein (LDL) to increase lysophosphatidylcholine (LPC) content. Phosphatidylcholines 56-75 phospholipase A2 group X Homo sapiens 36-41 22607224-7 2012 Efflux to PC-containing rHDL was stimulated by transfection of a nonfunctional ABCA1 mutant (W590S), suggesting that binding to ABCA1 represents a competing interaction. Phosphatidylcholines 10-12 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 79-84 22607224-7 2012 Efflux to PC-containing rHDL was stimulated by transfection of a nonfunctional ABCA1 mutant (W590S), suggesting that binding to ABCA1 represents a competing interaction. Phosphatidylcholines 10-12 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 128-133 23038705-5 2012 Tunicamycin administration induced BiP/GRP78 and GRP94 expression more potently in the p53-deficient mice than in controls and elevated phosphatidylcholine, the major lipid of ER, by a p53-dependent mechanism. Phosphatidylcholines 136-155 transformation related protein 53, pseudogene Mus musculus 185-188