PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9407551-5 1997 We therefore designed this study to investigate whether triggering of caspase activity and/or activation of PARP played a role in cerebellar granule cell (CGC) apoptosis elicited by peroxynitrite (ONOO-) or NO donors. oxido nitrite 197-202 poly (ADP-ribose) polymerase family, member 1 Mus musculus 108-112 12837848-16 2003 Secretion of PEMT-derived PC into lipoproteins was examined in vivo by injection of mice with [methyl-3H]methionine in the presence of Triton WR1339. Phosphatidylcholines 26-28 phosphatidylethanolamine N-methyltransferase Mus musculus 13-17 12837848-18 2003 Secretion of PEMT-derived PC into bile was enhanced in mice fed a HF/HC diet. Phosphatidylcholines 26-28 phosphatidylethanolamine N-methyltransferase Mus musculus 13-17 12837848-19 2003 These results demonstrate that the synthesis and targeting of PC produced by the PEMT pathway in the livers of mice differs in a gender- and diet-specific manner. Phosphatidylcholines 62-64 phosphatidylethanolamine N-methyltransferase Mus musculus 81-85 12842877-5 2003 This approach identified mutations in a single gene, YNL323W/LEM3, that conferred resistance to alkylphosphocholine drugs and inhibited internalization of NBD-labeled phosphatidylcholine. Phosphatidylcholines 167-186 Lem3p Saccharomyces cerevisiae S288C 61-65 12842877-11 2003 These data demonstrate a requirement for Lem3p expression for normal phosphatidylcholine and alkylphosphocholine drug transport across the plasma membrane of yeast. Phosphatidylcholines 69-88 Lem3p Saccharomyces cerevisiae S288C 41-46 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 39-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. Phosphatidylcholines 147-166 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 12810817-9 2003 Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile. Phosphatidylcholines 81-83 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 142-146 12810817-9 2003 Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile. Phosphatidylcholines 81-83 scavenger receptor class B, member 1 Mus musculus 151-156 12893687-0 2003 Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP, and CETP in plasma and peripheral lymph in humans. Phosphatidylcholines 42-61 lecithin-cholesterol acyltransferase Homo sapiens 71-75 12893687-1 2003 OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans. Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 53-71 12893687-1 2003 OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans. Phosphatidylcholines 72-91 apolipoprotein A1 Homo sapiens 93-102 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12799368-10 2003 Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine. Phosphatidylcholines 235-254 histone demethylase GIS1 Saccharomyces cerevisiae S288C 41-45 12813037-4 2003 Efflux of low density lipoprotein-derived, non-lipoprotein, plasma membrane, and newly synthesized pools of cell cholesterol by apoA-I was diminished in NPC1-/- cells, as was efflux of phosphatidylcholine and sphingomyelin. Phosphatidylcholines 185-204 NPC intracellular cholesterol transporter 1 Homo sapiens 153-157 12799368-10 2003 Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine. Phosphatidylcholines 235-254 histone demethylase GIS1 Saccharomyces cerevisiae S288C 71-76 12837922-9 2003 Blockade of phosphatidylcholine and phosphatidyl-ethanolamine transfer by a 60 min, 56 degrees C heating step or with anti-PLTP antibody revealed that PLTP accounts for almost 80% of the phospholipid transfer activity present in seminal plasma. Phosphatidylcholines 12-31 phospholipid transfer protein Homo sapiens 151-155 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 Csr1p Saccharomyces cerevisiae S288C 82-87 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 92-97 12869188-6 2003 In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover. Phosphatidylcholines 143-162 phospholipase D Saccharomyces cerevisiae S288C 128-133 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 15-21 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 Csr1p Saccharomyces cerevisiae S288C 45-50 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 55-60 12869188-7 2003 Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo. Phosphatidylcholines 120-139 lysophospholipase Saccharomyces cerevisiae S288C 92-97 12922169-13 2003 We demonstrate, using fluorescence resonance energy transfer, that at low concentrations, NAP-22 labeled with Texas Red binds equally well to liposomes of phosphatidylcholine either with or without the addition of 40 mol% cholesterol. Phosphatidylcholines 155-174 brain abundant membrane attached signal protein 1 Homo sapiens 90-96 12899624-0 2003 Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined. Phosphatidylcholines 157-176 phospholipase C beta 1 Homo sapiens 118-124 12899624-0 2003 Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined. Phosphatidylcholines 178-180 phospholipase C beta 1 Homo sapiens 118-124 12865160-10 2003 Moxonidine-induced induction of MKP-2 was time- and dose-dependent and could be blocked by the I(1)-antagonist efaroxan or by D609, an inhibitor of phosphatidylcholine-selective phospholipase C known to block downstream signaling events coupled to I(1)-receptors. Phosphatidylcholines 148-167 dual specificity phosphatase 4 Rattus norvegicus 32-37 12859204-5 2003 Compared to wild-type littermates, Abca1(-/-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin (SPH) (49-fold), and phosphatidylethanolamine (PE) (18-fold) showed even higher increases. Phosphatidylcholines 75-77 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 35-40 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12818350-9 2003 Messenger RNA export rate in PLA(2) (10(-3) unit/mL)- treated nuclear membrane was positively correlated with level of PC incorporation, both using ATP and GTP as substrates. Phosphatidylcholines 119-121 phospholipase A2 group IB Rattus norvegicus 29-35 12730219-9 2003 In contrast to oleic acid and sphingosine that exhibited inhibitory effects, phosphatidylcholine, phosphatidylserine, and phosphatidic acid stimulated MGAT2 activities. Phosphatidylcholines 77-96 mannoside acetylglucosaminyltransferase 2 Mus musculus 151-156 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 76-95 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 0-39 12842190-1 2003 CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction. Phosphatidylcholines 97-103 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 41-44 12842190-7 2003 These data suggest unique roles for the CCT protein isoforms in the differential regulation of PtdCho biosynthesis in specific tissues. Phosphatidylcholines 95-101 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 40-43 12940517-9 2003 In order to get more reliable results, we recommend that clinicians and researchers use NBD-phosphatidylcholines as PLA2 substrates in biological samples and start with an analytical separation of reaction products followed by image analysis of the fluorescent spots. Phosphatidylcholines 92-112 phospholipase A2 group IB Homo sapiens 116-120 12934648-7 2003 This enzyme hydrolyzed PAF and oxidatively modified phosphatidylcholine. Phosphatidylcholines 52-71 PCNA clamp associated factor Homo sapiens 23-26 12809502-2 2003 Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers. Phosphatidylcholines 198-217 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 72-75 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 interleukin 6 Homo sapiens 57-61 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 phospholipase A2 group X Homo sapiens 90-97 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 208-227 interleukin 6 Homo sapiens 62-66 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 229-231 interleukin 6 Homo sapiens 62-66 12865412-3 2003 KGF stimulated acetate incorporation into phosphatidylcholine, disaturated phosphatidylcholine, and phosphatidylglycerol more than 5% rat serum alone. Phosphatidylcholines 42-61 fibroblast growth factor 7 Homo sapiens 0-3 12872987-0 2003 Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide. Phosphatidylcholines 45-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-30 12872987-3 2003 LPS enhances expression of COX-2 mRNA and protein by activating sequentially phosphatidylcholine-specific phospholipase C (PC-PLC), protein kinase C (PKC) and phosphatidylcholine-specific phospholipase D (PC-PLD). Phosphatidylcholines 77-96 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 12809502-2 2003 Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers. Phosphatidylcholines 219-221 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 72-75 12668679-0 2003 A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. Phosphatidylcholines 80-99 phosphatidylethanolamine N-methyltransferase Mus musculus 27-71 12771001-5 2003 Dose-response curves were repeated after systemic infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) disks. Phosphatidylcholines 81-100 apolipoprotein A1 Homo sapiens 102-111 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12670959-4 2003 Measurements of cross-relaxation rates in two-dimensional nuclear Overhauser enhancement spectroscopy NMR experiments show that the five Phe rings of MARCKS-(151-175) penetrate into the acyl chain region of phosphatidylcholine bilayers containing phosphatidylglycerol or PI(4,5)P2. Phosphatidylcholines 207-226 myristoylated alanine rich protein kinase C substrate Homo sapiens 150-156 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 104-123 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12668679-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. Phosphatidylcholines 125-127 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12668679-6 2003 Moreover, female and, to a lesser extent, male Pemt-/- mice showed a striking 40% decrease in plasma PC and cholesterol in high density lipoproteins. Phosphatidylcholines 101-103 phosphatidylethanolamine N-methyltransferase Mus musculus 47-51 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 113-132 cut-like homeobox 1 Rattus norvegicus 23-26 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 301-320 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 301-320 NK2 homeobox 1 Homo sapiens 155-159 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 322-324 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. Phosphatidylcholines 322-324 NK2 homeobox 1 Homo sapiens 155-159 12771334-2 2003 In this study, it inhibited human and porcine pancreatic lipase activity in substrate emulsions containing bile salts and phosphatidylcholine, in the concentration range of 10-1000 mg/L. Phosphatidylcholines 122-141 lipase G, endothelial type Rattus norvegicus 57-63 12745074-6 2003 Furthermore, indolicidin caused significant morphological changes when tested for the membrane disrupting activity using liposomes (phosphatidylcholine/cholesterol; 10:1, w/w). Phosphatidylcholines 132-151 cathelicidin-4 Bos taurus 13-24 12962277-6 2003 Addition of a mol fraction of phosphatidylserine of 0.05 to membranes of phosphatidylcholine and cholesterol enhances the membrane binding of NAP-22. Phosphatidylcholines 73-92 brain abundant membrane attached signal protein 1 Homo sapiens 142-148 12764097-5 2003 Exposure of cortical neurons to neurotoxic concentrations of NMDA increased extracellular choline and activated hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 but did not induce significant degradation of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, or phosphatidylserine. Phosphatidylcholines 126-145 phospholipase A2 group IB Homo sapiens 174-190 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 134-136 cut-like homeobox 1 Rattus norvegicus 23-26 12743757-6 2003 Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors. Phosphatidylcholines 119-138 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 76-81 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 0-45 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 47-55 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 cut-like homeobox 1 Rattus norvegicus 185-188 12743757-6 2003 Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors. Phosphatidylcholines 119-138 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 86-91 12659848-3 2003 In this study, using fluorescence resonance energy transfer, we found that after A beta binds to raft-like membranes composed of monosialoganglioside GM1/cholesterol/sphingomyelin (1/1/1), the protein can translocate to the phosphatidylcholine membranes to which soluble A beta does not bind. Phosphatidylcholines 224-243 amyloid beta precursor protein Homo sapiens 81-87 12695484-3 2003 We show that Anx4 exhibited binding to liposomes (phosphatidylcholine:phosphatidylserine, 1:1) in the presence of Ca2+ and binding was reversible with EDTA. Phosphatidylcholines 50-69 annexin A4 Homo sapiens 13-17 12534371-1 2003 We investigated the kinetic behaviour and substrate specificity of PTEN (phosphatase and tensin homologue deleted on chromosome 10) using unilamellar vesicles containing substrate lipids in a background of phosphatidylcholine. Phosphatidylcholines 206-225 phosphatase and tensin homolog Homo sapiens 67-71 12761300-6 2003 These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway. Phosphatidylcholines 128-147 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 28-33 12761300-6 2003 These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway. Phosphatidylcholines 128-147 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 98-102 12691414-1 2003 OBJECT: In previous studies at their laboratory the authors showed that cytidinediphosphocholine (CDP-choline), an intermediate of phosphatidylcholine synthesis, decreases edema formation and blood-brain barrier disruption following traumatic brain injury (TBI). Phosphatidylcholines 131-150 cut-like homeobox 1 Rattus norvegicus 98-101 12604528-2 2003 More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA(2) at 10 micro M Ca(2+) was attenuated by these peptides while augmented product formation was observed in the presence of 5 mM Ca(2+). Phosphatidylcholines 33-52 phospholipase A2 group X Homo sapiens 81-88 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 108-112 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 144-148 12466019-7 2003 In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups. Phosphatidylcholines 41-60 phosphatidylethanolamine N-methyltransferase Mus musculus 144-148 12871410-6 2003 In contrast, addition of phosphatidylcholine/phosphatidylserine vesicles corrected prolonged clotting times caused by either anti-beta2GPI or antiprothrombin antibodies with LAC activity. Phosphatidylcholines 25-44 apolipoprotein H Homo sapiens 130-138 12633683-8 2003 The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM. Phosphatidylcholines 105-107 lipoprotein lipase Homo sapiens 26-44 12633683-8 2003 The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM. Phosphatidylcholines 105-107 lipoprotein lipase Homo sapiens 46-49 12562848-5 2003 PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho. Phosphatidylcholines 96-102 pleckstrin and Sec7 domain containing Homo sapiens 19-24 12632206-1 2003 We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes. Phosphatidylcholines 242-244 OXA1L mitochondrial inner membrane protein Homo sapiens 99-104 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). Phosphatidylcholines 74-93 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12562848-5 2003 PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho. Phosphatidylcholines 96-102 pleckstrin and Sec7 domain containing 2 Homo sapiens 29-34 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). Phosphatidylcholines 95-97 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. Phosphatidylcholines 133-152 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 8-13 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. Phosphatidylcholines 292-294 fatty acid desaturase 2 Rattus norvegicus 37-61 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. Phosphatidylcholines 292-294 fatty acid desaturase 2 Rattus norvegicus 49-60 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. Phosphatidylcholines 133-152 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 18-23 12482759-3 2003 A potential source for homocysteine is methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase in the liver. Phosphatidylcholines 92-111 phosphatidylethanolamine N-methyltransferase Mus musculus 115-159 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12547783-4 2003 For phosphatidylcholine spin-labeled at different positions down the sn-2 chain, the amplitude of the deuterium signal decreases toward the center of the membrane, and is reduced to zero from the C-12 atom position onward. Phosphatidylcholines 4-23 solute carrier family 38 member 5 Homo sapiens 69-73 12519189-4 2003 Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3. Phosphatidylcholines 61-80 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 95-99 12540796-5 2003 Cationic liposomes composed of DDAB and equimolar of a neutral lipid, egg yolk phosphatidylcholine (EPC), induced the strongest antigen-specific Th1 type immune responses among the cationic liposome investigated, whereas the liposomes composed of 2 cationic lipids, DDAB and DOEPC, induced an antigen-specific Th2 type immune response. Phosphatidylcholines 79-98 negative elongation factor complex member C/D Homo sapiens 145-148 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 transporter 1, ATP binding cassette subfamily B member Homo sapiens 22-27 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 transporter 2, ATP binding cassette subfamily B member Homo sapiens 29-34 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 SEC14 like lipid binding 4 Homo sapiens 39-44 12749692-1 2003 Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory. Phosphatidylcholines 97-116 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 134-140 12598036-5 2003 This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains. Phosphatidylcholines 88-107 brain abundant membrane attached signal protein 1 Homo sapiens 143-149 12598036-5 2003 This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains. Phosphatidylcholines 109-111 brain abundant membrane attached signal protein 1 Homo sapiens 143-149 13129817-0 2003 Apoptosis mediated by phosphatidylcholine-specific phospholipase C is associated with cAMP, p53 level, and cell-cycle distribution in vascular endothelial cells. Phosphatidylcholines 22-41 tumor protein p53 Homo sapiens 92-95 12519189-4 2003 Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3. Phosphatidylcholines 61-80 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 104-108 12244093-2 2002 The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin. Phosphatidylcholines 115-134 glucosidase II alpha subunit Homo sapiens 105-110 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Phosphatidylcholines 62-81 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 12899657-2 2003 Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC). Phosphatidylcholines 19-38 insulin Homo sapiens 0-7 12899657-2 2003 Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC). Phosphatidylcholines 40-42 insulin Homo sapiens 0-7 12359733-7 2002 A dramatic correlation exists between the ability of the sPLA(2)s to hydrolyze phosphatidylcholine-rich vesicles efficiently in vitro and the ability to release arachidonic acid when added exogenously to mammalian cells; the group V and X sPLA(2)s are uniquely efficient in this regard. Phosphatidylcholines 79-98 phospholipase A2 group IID Homo sapiens 57-65 12244093-2 2002 The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin. Phosphatidylcholines 136-138 glucosidase II alpha subunit Homo sapiens 105-110 12443983-1 2002 Citicoline, or CDP-choline, is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine that may act as a neuroprotector in several models of neurodegeneration. Phosphatidylcholines 91-110 cut like homeobox 1 Homo sapiens 15-18 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 1 Mus musculus 0-4 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 41-61 phospholipase A2 group IB Homo sapiens 98-114 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 2 Mus musculus 9-13 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. Phosphatidylcholines 140-159 phosphatidylserine synthase 1 Mus musculus 129-133 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 41-61 phospholipase A2 group IB Homo sapiens 116-120 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 63-65 phospholipase A2 group IB Homo sapiens 98-114 12472619-4 2002 As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2). Phosphatidylcholines 63-65 phospholipase A2 group IB Homo sapiens 116-120 12421918-7 2002 We found a similar frequency of phosphatidylcholine-specific CD5(+) B-1 cells in the two strains of mice. Phosphatidylcholines 32-51 CD5 antigen Mus musculus 61-64 12200438-2 2002 In this study, we have used both nutritional deprivation as well as a conditional temperature sensitive allele of PCT1 (CTP:phosphocholine cytidylyltransferase) coupled with an inactivated phosphatidylethanolamine methylation pathway to determine how cells respond to inactivation of phosphatidylcholine synthesis. Phosphatidylcholines 284-303 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 114-118 12200438-3 2002 Metabolic studies determined that phosphatidylcholine biosynthesis decreased to negligible levels within 1 h upon shift to the nonpermissive temperature for the temperature-sensitive PCT1 allele. Phosphatidylcholines 34-53 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 183-187 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 0-5 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 31-37 12200438-8 2002 Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity. Phosphatidylcholines 67-86 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 224-228 12228236-3 2002 Similarly, when apolipoprotein A-I removed cellular cholesterol, phosphatidylcholine, and sphingomyelin to generate high density lipoprotein, cholesterol synthesis from acetate subsequently increased, and sphingomyelin synthesis from acetate and serine also increased. Phosphatidylcholines 65-84 apolipoprotein A-I Mus musculus 16-34 12223447-0 2002 Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide. Phosphatidylcholines 0-19 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 108-147 12408975-3 2002 The oxidation products of 1- and/or 2-oleoyl phosphatidylcholine (PC) or phosphatidylethanolamine were the most potent compounds, while those of arachidonyl PC possessed only a weak inhibitory effect on the TFPI activity. Phosphatidylcholines 66-68 tissue factor pathway inhibitor Homo sapiens 207-211 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. Phosphatidylcholines 85-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 6-50 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. Phosphatidylcholines 85-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 52-56 12180909-1 2002 The apoptotic protein Bax, in oligomeric form, is effective in promoting both leakage and lipid mixing in liposomes composed of cardiolipin and phosphatidylethanolamine and/or phosphatidylcholine, upon the addition of calcium. Phosphatidylcholines 176-195 BCL2 associated X, apoptosis regulator Homo sapiens 22-25 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-83 choline phosphotransferase 1 Homo sapiens 0-25 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12167660-6 2002 Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation. Phosphatidylcholines 280-299 Gat1p Saccharomyces cerevisiae S288C 21-25 12167660-6 2002 Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation. Phosphatidylcholines 280-299 Gat2p Saccharomyces cerevisiae S288C 30-34 12167660-9 2002 Our results are consistent with a model whereby phosphatidic acid generated from phosphatidylcholine hydrolysis by Spo14p regulates susceptibility to choline-containing lysolipid analogs and drugs. Phosphatidylcholines 81-100 phospholipase D Saccharomyces cerevisiae S288C 115-121 12133835-6 2002 Disruption of the ROS3 gene resulted in a marked decrease in the internalization of fluorescence-labeled analogs of PE and phosphatidylcholine, whereas the uptake of fluorescence-labeled phosphatidylserine and endocytic markers was not affected. Phosphatidylcholines 123-142 Lem3p Saccharomyces cerevisiae S288C 18-22 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 108-127 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 129-131 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). Phosphatidylcholines 129-131 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12512933-2 2002 Addition of the major proteolipid (PLP) to phosphatidylcholine-cholesterol vesicles caused their clustering as determined by increase in O.D. Phosphatidylcholines 43-62 proteolipid protein 1 Homo sapiens 35-38 12442901-1 2002 We investigated the possible involvement of phosphatidylcholine-specific phospholipase C (PC-PLC) in the thyroid-stimulating hormone (TSH)-induced protein kinase C (PKC)/phospholipase D (PLD) activation in FRTL-5 thyroid cells. Phosphatidylcholines 44-63 protein kinase C, alpha Rattus norvegicus 165-168 12183451-4 2002 ALP inhibited PC synthesis at the CTP:phosphocholine cytidylyltransferase (CT) step in S49 cells, but not in S49(AR) cells. Phosphatidylcholines 14-16 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 34-73 12271462-2 2002 PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho. Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 21-39 12271462-2 2002 PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho. Phosphatidylcholines 0-6 phospholipase A2 group IB Homo sapiens 41-47 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat1p Saccharomyces cerevisiae S288C 140-144 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat2p Saccharomyces cerevisiae S288C 149-153 12167660-4 2002 To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids. Phosphatidylcholines 76-95 Gat2p Saccharomyces cerevisiae S288C 238-242 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 81-83 choline phosphotransferase 1 Homo sapiens 27-30 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 139-141 choline phosphotransferase 1 Homo sapiens 0-25 12359261-3 2002 Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells. Phosphatidylcholines 139-141 choline phosphotransferase 1 Homo sapiens 27-30 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 236-238 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 91-110 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. Phosphatidylcholines 112-114 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16