PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30284996-7	2018	After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%.	Phosphatidylcholines	194-213	lactotransferrin	Rattus norvegicus	33-35
29894783-4	2018	The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS).	Phosphatidylcholines	87-106	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-19
29894783-4	2018	The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS).	Phosphatidylcholines	108-110	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-19
30115754-4	2018	CRISPR/Cas9 knockout of CCTalpha in Caco2 cells (Caco2-KO cells) reduced PC synthesis by 50%.	Phosphatidylcholines	73-75	phosphate cytidylyltransferase 1A, choline	Homo sapiens	24-32
30115754-9	2018	Thus, reduced de novo PC synthesis in Caco2 cells enhances TG storage in large LDs and inhibits apoB48 chylomicron secretion.	Phosphatidylcholines	22-24	apolipoprotein B	Homo sapiens	96-102
30281112-1	2018	Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	101-120	phosphatidylethanolamine N-methyltransferase	Mus musculus	12-56
30281112-1	2018	Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	101-120	phosphatidylethanolamine N-methyltransferase	Mus musculus	58-62
29374817-1	2018	Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes.	Phosphatidylcholines	177-196	phospholipase A2 group X	Homo sapiens	0-26
29374817-1	2018	Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes.	Phosphatidylcholines	177-196	phospholipase A2 group X	Homo sapiens	28-33
29374817-1	2018	Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes.	Phosphatidylcholines	177-196	phospholipase A2 group X	Homo sapiens	108-113
32254972-3	2018	Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional beta-galactosidase.	Phosphatidylcholines	88-107	galactosidase beta 1	Homo sapiens	157-175
29774420-1	2018	PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property.	Phosphatidylcholines	13-32	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	108-117
29774420-1	2018	PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property.	Phosphatidylcholines	13-32	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	119-122
29774420-1	2018	PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property.	Phosphatidylcholines	35-37	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	108-117
29774420-1	2018	PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property.	Phosphatidylcholines	35-37	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	119-122
29691610-2	2018	We have investigated the interaction of recoverin with zwitterionic phosphatidylcholine bilayers, the major lipid component of the rod outer segment disk membranes, using both 31P and 19F solid-state nuclear magnetic resonance (NMR) and infrared spectroscopy.	Phosphatidylcholines	68-87	recoverin	Homo sapiens	40-49
30228369-4	2018	Acot7 overexpression modified specific phosphatidylcholine and phosphatidylethanolamine species in tibialis muscle of chow rats to levels similar to those observed in control HFD muscle.	Phosphatidylcholines	39-58	acyl-CoA thioesterase 7	Rattus norvegicus	0-5
30059845-10	2018	Human and Ldlr-/- mice shared 11 significant metabolites displaying the same direction of regulation: 5 phosphatidylcholines, 1 lysophosphatidylcholines, 5 sphingomyelins; ApoE-/- mice shared 10.	Phosphatidylcholines	104-124	low density lipoprotein receptor	Homo sapiens	10-14
29691610-8	2018	19F NMR results allow the observation of the calcium-myristoyl switch, the myristoyl group experiencing two different environments in the absence of Ca2+ and the immobilization of the recoverin myristoyl moiety in phosphatidylcholine membranes in the presence of Ca2+.	Phosphatidylcholines	214-233	recoverin	Homo sapiens	184-193
29895698-0	2018	Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice.	Phosphatidylcholines	68-87	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	42-47
29895698-1	2018	The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes.	Phosphatidylcholines	72-91	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	37-42
29895698-1	2018	The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes.	Phosphatidylcholines	72-91	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	43-47
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	8-27	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	94-101
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	8-27	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	47-92
29895698-1	2018	The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes.	Phosphatidylcholines	93-95	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	37-42
29895698-1	2018	The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes.	Phosphatidylcholines	93-95	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	43-47
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	8-27	CD320 antigen	Mus musculus	119-123
29895698-8	2018	Thus, T3-via THRbeta1 as a novel transcriptional activator regulates ABCB4 to increase ABCB4 protein levels at the canalicular membrane and promote PC secretion into bile.	Phosphatidylcholines	148-150	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	69-74
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	29-31	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	47-92
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	29-31	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	94-101
30007917-1	2018	De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) is required for VLDL secretion.	Phosphatidylcholines	29-31	CD320 antigen	Mus musculus	119-123
30148882-3	2018	Here we demonstrate that the cellular enzyme CCTalpha, responsible for the rate-limiting step in phosphatidylcholine synthesis, translocates from the nuclei to the cytoplasm upon infection and associates with the replication membranes, resulting in the rerouting of lipid synthesis from predominantly neutral lipids to phospholipids.	Phosphatidylcholines	97-116	phosphate cytidylyltransferase 1A, choline	Homo sapiens	45-53
29906468-7	2018	Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice.	Phosphatidylcholines	37-57	ferrochelatase	Mus musculus	140-144
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Phosphatidylcholines	111-130	heparan sulfate proteoglycan 2	Homo sapiens	35-38
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Phosphatidylcholines	111-130	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-46
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Phosphatidylcholines	132-134	heparan sulfate proteoglycan 2	Homo sapiens	35-38
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Phosphatidylcholines	132-134	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-46
30159399-4	2018	While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA).	Phosphatidylcholines	19-21	heparan sulfate proteoglycan 2	Homo sapiens	6-9
30159399-4	2018	While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA).	Phosphatidylcholines	66-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	74-77
30159399-6	2018	We observed that PC liposomes completely disintegrate in the presence of PLC, as conversion of PC to DAG progresses.	Phosphatidylcholines	17-19	heparan sulfate proteoglycan 2	Homo sapiens	73-76
30159399-11	2018	Conversely, PLD-treated PC liposomes remain stable up to extremely high conversions to PA.	Phosphatidylcholines	24-26	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	12-15
29866392-6	2018	RESULTS: Lpcat3-deficient macrophages displayed major reductions in the arachidonate content of phosphatidylcholines, phosphatidylethanolamines and, unexpectedly, plasmalogens.	Phosphatidylcholines	96-116	lysophosphatidylcholine acyltransferase 3	Mus musculus	9-15
29906468-7	2018	Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice.	Phosphatidylcholines	59-61	ferrochelatase	Mus musculus	140-144
29906468-7	2018	Furthermore, we found that the major phosphatidylcholines (PC) in the liver and the ratio of total PC to PPIX in the bile were decreased in Fech-mut mice compared to wild type mice.	Phosphatidylcholines	99-101	ferrochelatase	Mus musculus	140-144
29691802-9	2018	The dissociation constants for binding to PS/phosphatidylcholine (PC) liposomes of N-terminally acetylated (NAc) alpha-syn was lower than that of non NAc alpha-syn.	Phosphatidylcholines	45-64	synuclein alpha	Homo sapiens	113-122
30169917-4	2018	We identified lipids in plasma from 44 healthy subjects that correlated with CES1 activity as determined by PK parameters of methylphenidate including a ceramide (q value = 0.001) and a phosphatidylcholine (q value = 0.005).	Phosphatidylcholines	186-205	carboxylesterase 1	Homo sapiens	77-81
30169917-5	2018	Carriers of the CES1 143E allele had decreased methylphenidate metabolism and altered concentration of this phosphatidylcholine (q value = 0.040) and several high polyunsaturated fatty acid lipids (PUFAs).	Phosphatidylcholines	108-127	carboxylesterase 1	Homo sapiens	16-20
29345004-1	2018	Sphingomyelin synthase (SMS) is an enzyme that generates sphingomyelin (SM) from ceramide (CER) and phosphatidylcholine.	Phosphatidylcholines	100-119	spermine synthase	Mus musculus	24-27
29777000-7	2018	Analysis of loss-of-function mutants demonstrates that NMT1 and NMT3 synergistically regulate PC homeostasis, phase transition at the shoot apex, coordinated organ development, and fertility through overlapping but also specific functions.	Phosphatidylcholines	94-96	myristoyl-CoA:protein N-myristoyltransferase	Arabidopsis thaliana	55-59
29679463-1	2018	Cytidine-5"-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes.	Phosphatidylcholines	95-114	cut-like homeobox 1	Rattus norvegicus	30-33
29655284-8	2018	In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs.	Phosphatidylcholines	59-78	non-specific phospholipase C2	Arabidopsis thaliana	35-39
29853639-0	2018	Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated alpha-synuclein.	Phosphatidylcholines	11-30	synuclein alpha	Homo sapiens	112-127
28665188-2	2018	Analysis of the changes of lysozyme secondary structure upon its interactions with the model bilayer membranes composed of phosphatidylcholine and its mixtures with phosphatidylglycerol (10, 40, and 80 mol%) within the time interval of 100 ns showed that lipid-bound protein is characterized by the increased content of beta-structures.	Phosphatidylcholines	123-142	lysozyme	Homo sapiens	27-35
30108598-1	2018	Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis.	Phosphatidylcholines	126-145	Pyridoxal phosphate (PLP)-dependent transferases superfamily protein	Arabidopsis thaliana	21-43
30108598-1	2018	Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis.	Phosphatidylcholines	126-145	Pyridoxal phosphate (PLP)-dependent transferases superfamily protein	Arabidopsis thaliana	45-49
29853639-2	2018	Most previous studies on alpha-syn-membrane interactions have not used the physiologically relevant N-terminally acetylated (N-acetyl) alpha-syn form nor the most naturally abundant cellular lipid, i.e. phosphatidylcholine (PC).	Phosphatidylcholines	224-226	synuclein alpha	Homo sapiens	25-34
29660601-4	2018	To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D).	Phosphatidylcholines	103-122	cathelicidin antimicrobial peptide	Homo sapiens	74-78
29635711-6	2018	A smaller group of patients might develop gallstones primarily due low phosphatidylcholine concentrations in bile as a result of loss-of-function mutations of the ABCB4 transporter (low phospholipid-associated cholelithiasis syndrome).	Phosphatidylcholines	71-90	ATP binding cassette subfamily B member 4	Homo sapiens	163-168
29655284-8	2018	In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs.	Phosphatidylcholines	59-78	non-specific phospholipase C6	Arabidopsis thaliana	44-48
29578333-5	2018	The rate of phosphatidylcholine vesicle solubilization was enhanced for all variants, with approximately a threefold rate enhancement for apoA-I lacking Lys 206, 208, 238, and 239, or Glu 234 and 235.	Phosphatidylcholines	12-31	apolipoprotein A-I	Mus musculus	138-144
29602217-4	2018	The (FITC-AC)-royalisin P11 bound with high specificity to ox-LDL in a dose-dependent manner, through the binding to major lipid components in ox-LDL (lysophosphatidylcholine and oxidized phosphatidylcholine).	Phosphatidylcholines	155-174	defensin-1	Apis mellifera	14-23
29519816-1	2018	The activity of CTP:phosphocholine cytidylyltransferase (CCT), a key enzyme in phosphatidylcholine synthesis, is regulated by reversible interactions of a lipid-inducible amphipathic helix (domain M) with membrane phospholipids.	Phosphatidylcholines	79-98	solute carrier family 25 member 1	Homo sapiens	16-19
29670126-0	2018	Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation.	Phosphatidylcholines	43-62	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	95-100
29670126-5	2018	In this study, we found that trypsin treatment causes rapid release of phosphatidylcholine (PC) and cholesterol from BHK/ABCA1 cells, and that the time course of lipid release coincides with those of trypsin digestion of extracellular domains (ECDs) of surface ABCA1 and of release of ECD fragments into the medium.	Phosphatidylcholines	71-90	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	121-126
29670126-5	2018	In this study, we found that trypsin treatment causes rapid release of phosphatidylcholine (PC) and cholesterol from BHK/ABCA1 cells, and that the time course of lipid release coincides with those of trypsin digestion of extracellular domains (ECDs) of surface ABCA1 and of release of ECD fragments into the medium.	Phosphatidylcholines	92-94	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	121-126
31249994-3	2018	Sn-2 phosphatidylcholine prodrugs delivered by hemifusion of nanoparticle and cell phospholipid membranes functioned as phosphatidylcholine mimics, circumventing the challenges of endosome sequestration and release.	Phosphatidylcholines	5-24	solute carrier family 38 member 5	Homo sapiens	0-4
31249994-8	2018	We have demonstrated that Sn-2 phosphatidylcholine prodrugs function as phosphatidylcholine mimics following reported pathways of phosphatidylcholine distribution and metabolism.	Phosphatidylcholines	31-50	solute carrier family 38 member 5	Homo sapiens	26-30
31249994-8	2018	We have demonstrated that Sn-2 phosphatidylcholine prodrugs function as phosphatidylcholine mimics following reported pathways of phosphatidylcholine distribution and metabolism.	Phosphatidylcholines	72-91	solute carrier family 38 member 5	Homo sapiens	26-30
29716960-2	2018	Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways.	Phosphatidylcholines	7-26	phosphatidylethanolamine N-methyltransferase	Homo sapiens	201-245
29716960-2	2018	Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways.	Phosphatidylcholines	7-26	phosphatidylethanolamine N-methyltransferase	Homo sapiens	247-251
29716960-2	2018	Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways.	Phosphatidylcholines	28-30	phosphatidylethanolamine N-methyltransferase	Homo sapiens	201-245
29716960-2	2018	Plasma phosphatidylcholine (PC), the major phospholipid of circulating lipoproteins, is synthesized in human liver by two biologically diverse pathways: the cytidine diphosphocholine (CDP):choline and phosphatidylethanolamine N-methyltransferase (PEMT) pathways.	Phosphatidylcholines	28-30	phosphatidylethanolamine N-methyltransferase	Homo sapiens	247-251
29728535-1	2018	The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain.	Phosphatidylcholines	18-37	phosphate cytidylyltransferase 1A, choline	Homo sapiens	76-121
29728535-1	2018	The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain.	Phosphatidylcholines	18-37	phosphate cytidylyltransferase 1A, choline	Homo sapiens	123-131
29728535-1	2018	The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain.	Phosphatidylcholines	39-41	phosphate cytidylyltransferase 1A, choline	Homo sapiens	76-121
29728535-1	2018	The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain.	Phosphatidylcholines	39-41	phosphate cytidylyltransferase 1A, choline	Homo sapiens	123-131
29695812-0	2018	Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men.	Phosphatidylcholines	16-35	insulin	Homo sapiens	99-106
29695812-1	2018	Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity.	Phosphatidylcholines	0-19	insulin	Homo sapiens	110-117
29695812-1	2018	Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity.	Phosphatidylcholines	21-23	insulin	Homo sapiens	110-117
29578333-8	2018	However, this protein was more effective in releasing cellular phosphatidylcholine and sphingomyelin from Abca1-null mice macrophage foam cells.	Phosphatidylcholines	63-82	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	106-111
29805971-9	2018	The greater efficacy of L-PC seen in NAFLD volunteers may reflect improved bioavailability of PC owing to better protection of the microencapsulated PC from gastrointestinal enzymes and possibly enhanced hepatic delivery of L-PC particles.	Phosphatidylcholines	26-28	proprotein convertase subtilisin/kexin type 7	Homo sapiens	224-228
29178478-3	2018	The main pathway for the synthesis of PC is the Kennedy (CDP-choline) pathway.	Phosphatidylcholines	38-40	cut like homeobox 1	Homo sapiens	57-60
29178478-4	2018	In this pathway, choline is converted to phosphocholine by choline kinase, phosphocholine is metabolized to CDP-choline by the rate-determining enzyme for this pathway, CTP:phosphocholine cytidylyltransferase, and cholinephosphotransferase condenses CDP-choline with diacylglycerol to produce PC.	Phosphatidylcholines	293-295	cut like homeobox 1	Homo sapiens	108-111
29805971-9	2018	The greater efficacy of L-PC seen in NAFLD volunteers may reflect improved bioavailability of PC owing to better protection of the microencapsulated PC from gastrointestinal enzymes and possibly enhanced hepatic delivery of L-PC particles.	Phosphatidylcholines	94-96	proprotein convertase subtilisin/kexin type 7	Homo sapiens	24-28
29132829-0	2018	The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase.	Phosphatidylcholines	83-102	phospholipase A2 group IB	Homo sapiens	128-144
29437858-7	2018	This work includes several examples of lipid pathways for phosphatidylcholine and phosphatidylethanolamine lipids that help elucidate the molecular mechanism of lipid binding in P-gp.	Phosphatidylcholines	58-77	ATP binding cassette subfamily B member 1	Homo sapiens	178-182
29655691-8	2018	All nanoformulations conserved the antioxidant potential of AE, while phosphatidylcholine interfered with MAO-A inhibition assay.	Phosphatidylcholines	70-89	monoamine oxidase A	Homo sapiens	106-111
29396267-7	2018	SMAC/Diablo silencing decreased the levels of phospholipids, including phosphatidylcholine.	Phosphatidylcholines	71-90	diablo, IAP-binding mitochondrial protein	Mus musculus	0-4
29396267-7	2018	SMAC/Diablo silencing decreased the levels of phospholipids, including phosphatidylcholine.	Phosphatidylcholines	71-90	diablo, IAP-binding mitochondrial protein	Mus musculus	5-11
29132829-0	2018	The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase.	Phosphatidylcholines	83-102	lipase C, hepatic type	Homo sapiens	149-171
29420298-4	2018	Model simulations perfectly recapitulate the measured dependence of bile salt-dependent biliary lipid extraction rates upon modulation of the membrane cholesterol (lack or overexpression of the cholesterol transporter Abcg5-Abcg8) and phosphatidylcholine (lack of Mdr2, also known as Abcb4) content.	Phosphatidylcholines	235-254	ATP binding cassette subfamily G member 5	Homo sapiens	218-223
29420298-4	2018	Model simulations perfectly recapitulate the measured dependence of bile salt-dependent biliary lipid extraction rates upon modulation of the membrane cholesterol (lack or overexpression of the cholesterol transporter Abcg5-Abcg8) and phosphatidylcholine (lack of Mdr2, also known as Abcb4) content.	Phosphatidylcholines	235-254	ATP binding cassette subfamily G member 8	Homo sapiens	224-229
29527260-1	2018	Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidylcholine.	Phosphatidylcholines	101-120	ectonucleotide pyrophosphatase/phosphodiesterase 7	Homo sapiens	0-25
29343537-5	2018	Previous work revealed that StarD7 is required for efficient mitochondrial import of phosphatidylcholine (PC) and serves a critical role in mitochondrial function and morphology.	Phosphatidylcholines	85-104	StAR related lipid transfer domain containing 7	Homo sapiens	28-34
29343537-5	2018	Previous work revealed that StarD7 is required for efficient mitochondrial import of phosphatidylcholine (PC) and serves a critical role in mitochondrial function and morphology.	Phosphatidylcholines	106-108	StAR related lipid transfer domain containing 7	Homo sapiens	28-34
29343537-6	2018	Combining site-directed mutagenesis and photoaffinity labeling experiments, we demonstrate that the steroidogenic acute regulatory transfer domain of StarD7 harbors a common binding site for PC and ceramide.	Phosphatidylcholines	191-193	StAR related lipid transfer domain containing 7	Homo sapiens	150-156
29453864-6	2018	Finally, we show that in Zn deficient conditions loss of function of LPCAT1 increases the phospholipid Lyso-PhosphatidylCholine/PhosphatidylCholine ratio, the expression of the Pi transporter PHT1;1, and that this leads to shoot Pi accumulation.	Phosphatidylcholines	108-127	lysophosphatidylcholine acyltransferase 1	Homo sapiens	69-75
29301859-3	2018	Here, we identify the START domain-containing protein STARD7 as an intramitochondrial lipid transfer protein for phosphatidylcholine.	Phosphatidylcholines	113-132	StAR related lipid transfer domain containing 7	Homo sapiens	54-60
29301859-6	2018	Mitochondrial STARD7 is necessary and sufficient for the accumulation of phosphatidylcholine in the inner membrane and for the maintenance of respiration and cristae morphogenesis.	Phosphatidylcholines	73-92	StAR related lipid transfer domain containing 7	Homo sapiens	14-20
29416063-0	2018	AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.	Phosphatidylcholines	21-40	aryl hydrocarbon receptor	Homo sapiens	0-3
29300825-5	2018	NPC2 enzyme activity was determined using fluorescent phosphatidylcholine as a substrate.	Phosphatidylcholines	54-73	non-specific phospholipase C2	Arabidopsis thaliana	0-4
29300825-9	2018	Key Results: The heterologously expressed protein possessed phospholipase C activity, being able to hydrolyse phosphatidylcholine to diacylglycerol.	Phosphatidylcholines	110-129	phospholipase C1	Arabidopsis thaliana	60-75
29560412-2	2018	Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2).	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	30-33
29560412-2	2018	Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2).	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	164-167
29560412-2	2018	Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2).	Phosphatidylcholines	135-154	phospholipase D1	Homo sapiens	172-176
29560412-2	2018	Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2).	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	181-188
29416063-0	2018	AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.	Phosphatidylcholines	21-40	nuclear receptor subfamily 0 group B member 2	Homo sapiens	8-11
29416063-5	2018	Adenoviral-mediated expression of AhR in obese mice increases PC levels and exacerbates steatosis, effects that are blunted by SHP co-expression or Pemt downregulation.	Phosphatidylcholines	62-64	aryl-hydrocarbon receptor	Mus musculus	34-37
29416063-7	2018	This study identifies AhR and SHP as new physiological regulators of PC/SAM levels.	Phosphatidylcholines	69-71	aryl hydrocarbon receptor	Homo sapiens	22-25
29284086-1	2018	Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) membranes, and a mixture of the two.	Phosphatidylcholines	308-327	sperm adhesion molecule 1	Homo sapiens	189-193
29284086-1	2018	Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) membranes, and a mixture of the two.	Phosphatidylcholines	329-331	sperm adhesion molecule 1	Homo sapiens	189-193
29416063-7	2018	This study identifies AhR and SHP as new physiological regulators of PC/SAM levels.	Phosphatidylcholines	69-71	nuclear receptor subfamily 0 group B member 2	Homo sapiens	30-33
29353041-3	2018	FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma.	Phosphatidylcholines	129-148	fatty acid desaturase 2	Mus musculus	0-5
29353041-3	2018	FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma.	Phosphatidylcholines	150-152	fatty acid desaturase 2	Mus musculus	0-5
29353041-5	2018	These results supposed that Mead acid in PC is important as a component of VLDL.	Phosphatidylcholines	41-43	CD320 antigen	Mus musculus	75-79
29290583-3	2018	The basis of the ER-mitochondrial PC synthesis pathway is the exclusive mitochondrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates phosphatidylethanolamine (PE).	Phosphatidylcholines	34-36	pleckstrin and Sec7 domain containing	Homo sapiens	157-161
29032301-5	2018	Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles.	Phosphatidylcholines	151-170	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
29032301-5	2018	Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles.	Phosphatidylcholines	151-170	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
29032301-5	2018	Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles.	Phosphatidylcholines	172-174	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
29032301-5	2018	Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles.	Phosphatidylcholines	172-174	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
29569242-10	2018	These results suggest that the inhibitory effect of egg-yolk CerPCho and PtdCho on cholesterol transport might be due to their interference with the physicochemical properties of micelles and their regulations on the expression of the NPC1L1 gene.	Phosphatidylcholines	73-79	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	235-241
29411327-9	2018	CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome.	Phosphatidylcholines	64-83	phosphate cytidylyltransferase 1A, choline	Homo sapiens	119-124
29411327-9	2018	CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome.	Phosphatidylcholines	64-83	lysophosphatidylcholine acyltransferase 1	Homo sapiens	126-132
29411327-9	2018	CONCLUSIONS: The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome.	Phosphatidylcholines	64-83	choline phosphotransferase 1	Homo sapiens	134-139
29358673-4	2018	Here we show that LD content of CRC cells positively correlates with the expression of lysophosphatidylcholine acyltransferase 2 (LPCAT2), an LD-localised enzyme supporting phosphatidylcholine synthesis.	Phosphatidylcholines	91-110	lysophosphatidylcholine acyltransferase 2	Homo sapiens	130-136
29293603-5	2018	We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs.	Phosphatidylcholines	33-52	neural retina leucine zipper gene	Mus musculus	142-145
29154090-2	2018	The canonical enzymes PLD1 and PLD2 enact their diverse effects through hydrolyzing the membrane lipid phosphatidylcholine to generate the second messenger and signaling lipid phosphatidic acid (PA).	Phosphatidylcholines	103-122	phospholipase D1	Mus musculus	22-26
29293603-5	2018	We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs.	Phosphatidylcholines	33-52	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	149-155
29154090-2	2018	The canonical enzymes PLD1 and PLD2 enact their diverse effects through hydrolyzing the membrane lipid phosphatidylcholine to generate the second messenger and signaling lipid phosphatidic acid (PA).	Phosphatidylcholines	103-122	phospholipase D2	Mus musculus	31-35
29428958-1	2018	BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B.	Phosphatidylcholines	108-127	patatin like phospholipase domain containing 6	Homo sapiens	17-43
29428958-1	2018	BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B.	Phosphatidylcholines	108-127	patatin like phospholipase domain containing 6	Homo sapiens	45-48
29428958-1	2018	BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B.	Phosphatidylcholines	129-131	patatin like phospholipase domain containing 6	Homo sapiens	17-43
29428958-1	2018	BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B.	Phosphatidylcholines	129-131	patatin like phospholipase domain containing 6	Homo sapiens	45-48
28879486-2	2018	In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios.	Phosphatidylcholines	95-114	cytochrome c, somatic	Homo sapiens	145-150
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	139-158	phospholipase A2 group IB	Homo sapiens	32-48
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	139-158	phospholipase A2 group IB	Homo sapiens	50-54
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	139-158	ectonucleotide pyrophosphatase/phosphodiesterase 6	Homo sapiens	60-109
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	139-158	ectonucleotide pyrophosphatase/phosphodiesterase 6	Homo sapiens	111-116
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	139-158	phosphoethanolamine/phosphocholine phosphatase 1	Homo sapiens	214-222
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	369-388	phospholipase A2 group IB	Homo sapiens	32-48
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	369-388	phospholipase A2 group IB	Homo sapiens	50-54
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	369-388	ectonucleotide pyrophosphatase/phosphodiesterase 6	Homo sapiens	60-109
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	369-388	ectonucleotide pyrophosphatase/phosphodiesterase 6	Homo sapiens	111-116
28864658-4	2018	Here, we propose that 2 enzymes-phospholipase A2 (PLA2) and ectonucleotide pyrophophatase/phosphodiesterase 6 (ENPP6)-act in sequence upon phosphatidylcholine found in MV membranes to produce phosphocholine, which PHOSPHO1 can hydrolyze to liberate Pi This hypothesis is supported by evidence that both enzymes are expressed in mineralizing cells and data showing that phosphatidylcholine is broken down in MVs during mineralization.	Phosphatidylcholines	369-388	phosphoethanolamine/phosphocholine phosphatase 1	Homo sapiens	214-222
28879486-2	2018	In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios.	Phosphatidylcholines	286-305	cytochrome c, somatic	Homo sapiens	145-150
28879486-2	2018	In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios.	Phosphatidylcholines	307-309	cytochrome c, somatic	Homo sapiens	145-150
30689326-9	2018	The anti-tuberculosis chemotherapy gives rise to activation of phospholipase A2 that shows membrane destructive effect on mononuclears of peripheral blood and results in disorganization of their membranes manifesting in cumulation of lysophospholipids at simultaneous decreasing of percentage content of phosphatidylserine and phosphatidylcholine.	Phosphatidylcholines	327-346	phospholipase A2 group IB	Homo sapiens	63-79
29247563-13	2018	Citicoline increased choline acetyltransferase expression for phosphatidylcholine synthesis after hypoglycaemia.	Phosphatidylcholines	62-81	choline O-acetyltransferase	Rattus norvegicus	21-46
29258435-1	2017	BACKGROUND: Nonspecific phospholipase C (NPC), which belongs to a phospholipase C subtype, is a class of phospholipases that hydrolyzes the primary membrane phospholipids, such as phosphatidylcholine, to yield sn-1, 2-diacylglycerol and a phosphorylated head-group.	Phosphatidylcholines	180-199	phosphoinositide phospholipase C 2-like	Gossypium hirsutum	24-39
30109649-3	2018	However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis.	Phosphatidylcholines	131-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17
30109649-3	2018	However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis.	Phosphatidylcholines	152-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17
30109649-5	2018	This assay exhibits a strong fluorescence signal upon Ca2+ complexation with the PLD-generated PA and is not limited to PC as the substrate but allows the use of natural phospholipids with various headgroups.	Phosphatidylcholines	120-122	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	81-84
28780751-1	2018	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
28780751-1	2018	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
29186713-0	2018	Phosphatidylcholine Causes Lipolysis and Apoptosis in Adipocytes through the Tumor Necrosis Factor Alpha-Dependent Pathway.	Phosphatidylcholines	0-19	tumor necrosis factor	Mus musculus	77-104
29186713-10	2018	Through in vivo experiments, we demonstrated that PPC injection not only stimulated the local lipolysis and apoptosis, resulting in weight loss, but also induced TNFalpha mRNA expression and neutrophil infiltration.	Phosphatidylcholines	50-53	tumor necrosis factor	Mus musculus	162-170
29186713-12	2018	In conclusion, we suggest that PPC induces lipolysis and apoptosis in adipocytes through TNFalpha-dependent pathways.	Phosphatidylcholines	31-34	tumor necrosis factor	Mus musculus	89-97
29577851-6	2018	METHODS: Recombinant human alpha-synuclein was expressed and isolated and incubated in the presence of phosphatidylcholine and phosphatidylserine (PC/PS) containing liposomes.	Phosphatidylcholines	103-122	synuclein alpha	Homo sapiens	27-42
29258435-1	2017	BACKGROUND: Nonspecific phospholipase C (NPC), which belongs to a phospholipase C subtype, is a class of phospholipases that hydrolyzes the primary membrane phospholipids, such as phosphatidylcholine, to yield sn-1, 2-diacylglycerol and a phosphorylated head-group.	Phosphatidylcholines	180-199	phosphoinositide phospholipase C 2-like	Gossypium hirsutum	66-81
28988476-5	2017	This approach is demonstrated to differentiate sn-positional and double-bond-positional isomers, such as the regioisomeric phosphatidylcholines PC 16:0/18:1(n-9) and PC 18:1(n-9)/16:0, and has been integrated into an LC-MS3 workflow.	Phosphatidylcholines	123-143	MS3	Homo sapiens	220-223
29030428-1	2017	Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high-density lipoproteins (HDL) from discoidal to spherical particles.	Phosphatidylcholines	129-148	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
29030428-1	2017	Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high-density lipoproteins (HDL) from discoidal to spherical particles.	Phosphatidylcholines	129-148	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
29199275-3	2017	Here we report a crystal structure of a LIMP-2 luminal domain dimer with bound cholesterol and phosphatidylcholine.	Phosphatidylcholines	95-114	scavenger receptor class B, member 2	Mus musculus	40-46
29199275-4	2017	Binding of these lipids alters LIMP-2 from functioning as a glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine.	Phosphatidylcholines	184-203	scavenger receptor class B, member 2	Mus musculus	31-37
29141586-13	2017	During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1.	Phosphatidylcholines	61-80	phospholipase D P1	Arabidopsis thaliana	139-147
29141586-13	2017	During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1.	Phosphatidylcholines	82-84	phospholipase D P1	Arabidopsis thaliana	139-147
29142222-3	2017	In this work we have performed a biophysical study of human ATG3 interaction with membranes containing phosphatidylethanolamine, phosphatidylcholine and anionic phospholipids.	Phosphatidylcholines	129-148	autophagy related 3	Homo sapiens	60-64
28822686-3	2017	The present work applied simultaneous surface plasmon resonance and electrochemical impedance spectroscopy measurements to show that, in absence of the substrate, hMAGL can remove phospholipid molecules from the membrane and, thereby, disintegrate pre-formed, intact, tethered phospholipid bilayer membrane mimetics (tBLMs) composed of unsaturated phosphatidylcholines.	Phosphatidylcholines	348-368	monoglyceride lipase	Homo sapiens	163-168
29093267-10	2017	Lipidomics and metabolomics revealed alterations of TG and phosphatidylcholine (PC) lipid species by miR-141/200c deficiency.	Phosphatidylcholines	59-78	microRNA 141	Mus musculus	101-108
29093267-10	2017	Lipidomics and metabolomics revealed alterations of TG and phosphatidylcholine (PC) lipid species by miR-141/200c deficiency.	Phosphatidylcholines	80-82	microRNA 141	Mus musculus	101-108
28114790-5	2017	Thus, the specific activities of the patient"s LPL determined with triolein emulsified with PC were significantly higher than those with PE, PS, PI or LPC as emulsifiers.	Phosphatidylcholines	92-94	lipoprotein lipase	Homo sapiens	47-50
29054999-4	2017	The spectrum of self-antigens captured by CD1b skews toward abundant membrane phospholipids such as phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	100-119	CD1b molecule	Homo sapiens	42-46
29035283-0	2017	mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion.	Phosphatidylcholines	18-37	CREB regulated transcription coactivator 1	Mus musculus	0-6
29035283-7	2017	Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	166-185	CREB regulated transcription coactivator 1	Mus musculus	14-20
29035283-7	2017	Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	166-185	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	101-109
29035283-7	2017	Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	187-189	CREB regulated transcription coactivator 1	Mus musculus	14-20
29035283-7	2017	Additionally, mTORC1 promoted TAG secretion by regulating phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	187-189	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	101-109
29035283-8	2017	Increasing PC synthesis in mice lacking mTORC1 rescued hepatosteatosis and restored TAG secretion.	Phosphatidylcholines	11-13	CREB regulated transcription coactivator 1	Mus musculus	40-46
28807933-1	2017	We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	134-153	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	28-38
28807933-1	2017	We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	134-153	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	39-45
28807933-1	2017	We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	155-157	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	28-38
28807933-1	2017	We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	155-157	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	39-45
28844900-7	2017	In further studies, NCL-240 encapsulated in phosphatidylcholine/cholesterol liposomes was combined with freely dissolved 2-DG.	Phosphatidylcholines	44-63	nucleolin	Homo sapiens	20-23
29104923-2	2017	Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine.	Phosphatidylcholines	140-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
29104923-2	2017	Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine.	Phosphatidylcholines	140-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
28855256-5	2017	The research in my lab and others demonstrated that the regulated and rate-limiting step in the choline pathway for PC biosynthesis was catalyzed by CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	116-118	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	149-188
28855256-8	2017	The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC.	Phosphatidylcholines	32-34	phosphatidylethanolamine N-methyltransferase	Homo sapiens	64-108
28855256-8	2017	The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC.	Phosphatidylcholines	32-34	phosphatidylethanolamine N-methyltransferase	Homo sapiens	110-114
28855256-8	2017	The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC.	Phosphatidylcholines	158-160	phosphatidylethanolamine N-methyltransferase	Homo sapiens	64-108
28855256-8	2017	The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC.	Phosphatidylcholines	158-160	phosphatidylethanolamine N-methyltransferase	Homo sapiens	110-114
28802697-5	2017	The MP1-lipid membrane interaction was studied using Langmuir phosphatidylcholine and phosphatidylserine (PS) monolayers as model membrane systems.	Phosphatidylcholines	62-81	pitrilysin metallopeptidase 1	Homo sapiens	4-7
29044208-5	2017	TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated.	Phosphatidylcholines	60-79	transforming growth factor beta 1	Homo sapiens	0-9
29044208-5	2017	TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated.	Phosphatidylcholines	60-79	insulin like growth factor 1	Homo sapiens	14-19
29044208-5	2017	TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated.	Phosphatidylcholines	81-83	transforming growth factor beta 1	Homo sapiens	0-9
29044208-5	2017	TGF-beta1 and IGF-1 markedly stimulated the biosynthesis of phosphatidylcholine (PC) before sphingomyelin (SM) and lysophosphatidylcholine (LPC) species were stimulated.	Phosphatidylcholines	81-83	insulin like growth factor 1	Homo sapiens	14-19
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylcholines	186-205	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
28676520-1	2017	BACKGROUND: PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine.	Phosphatidylcholines	18-37	phosphatidylcholine transfer protein	Homo sapiens	12-16
28687611-3	2017	A screening campaign revealed retinol (vitamin A alcohol) and all-trans retinoic acid (vitamin A acid) (RA) as hits that time-dependently (>=24 h) deplete phosphatidylcholine-bound polyunsaturated fatty acids (PUFA-PCs) from NIH-3T3 mouse fibroblasts while inducing Akt activation (EC50   0.1-1 microM).	Phosphatidylcholines	158-177	thymoma viral proto-oncogene 1	Mus musculus	269-272
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylcholines	186-205	ATPase phospholipid transporting 8B1	Homo sapiens	126-132
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylcholines	207-209	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylcholines	207-209	ATPase phospholipid transporting 8B1	Homo sapiens	126-132
28718450-4	2017	Here, all-atom molecular dynamics simulations of the mammalian StART-like PtdIns/phosphatidylcholine (PtdCho) transfer protein PITPalpha, both on membrane bilayers and in solvated systems, informed downstream biochemical analyses that tested key aspects of the hypotheses generated by the molecular dynamics simulations.	Phosphatidylcholines	81-100	phosphatidylinositol transfer protein alpha	Homo sapiens	127-136
28808571-3	2017	In addition, CRP may form a complex with oxidized low-density lipoprotein (oxLDL) via phosphatidylcholine, thus decreasing its pro-inflammatory effects within macrophages.	Phosphatidylcholines	86-105	C-reactive protein	Homo sapiens	13-16
28821867-0	2017	Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer.	Phosphatidylcholines	133-152	START domain containing 7	Mus musculus	57-63
28711489-7	2017	This study showed that STAT1 and interferon-regulated genes was up-regulated after the CD diet consumption and that the Stat1 mRNA level was negatively correlated with liver phosphatidylcholine level.	Phosphatidylcholines	174-193	signal transducer and activator of transcription 1	Mus musculus	23-28
28711489-7	2017	This study showed that STAT1 and interferon-regulated genes was up-regulated after the CD diet consumption and that the Stat1 mRNA level was negatively correlated with liver phosphatidylcholine level.	Phosphatidylcholines	174-193	signal transducer and activator of transcription 1	Mus musculus	120-125
28754826-0	2017	Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.	Phosphatidylcholines	45-64	secreted phosphoprotein 1	Mus musculus	0-11
28754826-3	2017	In mice, lack of OPN enhanced cholesterol 7alpha-hydroxylase (CYP7A1) levels and promoted loss of phosphatidylcholine (PC) content in liver; in vivo treatment with recombinant (r)OPN caused opposite effects.	Phosphatidylcholines	98-117	secreted phosphoprotein 1	Mus musculus	17-20
28754826-3	2017	In mice, lack of OPN enhanced cholesterol 7alpha-hydroxylase (CYP7A1) levels and promoted loss of phosphatidylcholine (PC) content in liver; in vivo treatment with recombinant (r)OPN caused opposite effects.	Phosphatidylcholines	119-121	secreted phosphoprotein 1	Mus musculus	17-20
28754826-6	2017	In vivo inhibition of cholesterogenesis normalized liver PC content in OPN-KO mice, demonstrating that OPN regulates the cross-talk between liver CHOL and PC metabolism.	Phosphatidylcholines	57-59	secreted phosphoprotein 1	Mus musculus	103-106
28754826-8	2017	In conclusion, OPN regulates CYP7A1 levels and the metabolic fate of liver acetyl-CoA as a result of CHOL and PC metabolism interplay.	Phosphatidylcholines	110-112	secreted phosphoprotein 1	Mus musculus	15-18
28821867-1	2017	StarD7 facilitates phosphatidylcholine (PC) transfer to mitochondria, and is essential for mitochondrial homeostasis.	Phosphatidylcholines	19-38	START domain containing 7	Mus musculus	0-6
28821867-5	2017	A truncated form of StarD7 lacking the TM domain is distributed in the inner space of the mitochondria, and cannot reverse mitochondrial abnormalities, such as complex formation and PC content, when re-expressed in StarD7-KO HEPA-1 cells.	Phosphatidylcholines	182-184	START domain containing 7	Mus musculus	20-26
28786767-2	2017	The 10-kDa AtACBP6 is the smallest in this protein family, and recombinant AtACBP6 interacts with lipids in vitro by binding to acyl-CoA esters and phosphatidylcholine.	Phosphatidylcholines	148-167	acyl-CoA-binding protein 6	Arabidopsis thaliana	11-18
28786767-2	2017	The 10-kDa AtACBP6 is the smallest in this protein family, and recombinant AtACBP6 interacts with lipids in vitro by binding to acyl-CoA esters and phosphatidylcholine.	Phosphatidylcholines	148-167	acyl-CoA-binding protein 6	Arabidopsis thaliana	75-82
28903399-3	2017	We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells.	Phosphatidylcholines	28-47	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	77-80
28551717-0	2017	Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection.	Phosphatidylcholines	19-38	immunoglobulin heavy constant mu	Mus musculus	39-42
28551717-3	2017	We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance.	Phosphatidylcholines	43-62	immunoglobulin heavy constant mu	Mus musculus	63-66
28654865-5	2017	Of the two phosphatidylcholine-specific PLD enzymes, only PLD1, but not PLD2, mRNA was down-regulated by doxorubicin treatment.	Phosphatidylcholines	11-30	phospholipase D1	Homo sapiens	58-62
28784961-9	2017	As previously observed, the PLC-delta1 PH domain is PI(4,5)P2 specific, shows weaker binding towards phosphatidylinositol 4-phosphate, and no binding to pure phosphatidylcholine SLBs.	Phosphatidylcholines	158-177	phospholipase C delta 1	Homo sapiens	28-38
28726782-9	2017	Pretreatment with the PKCzeta activator phosphatidylcholine remarkably attenuated gut injury by suppressing apoptosis.	Phosphatidylcholines	40-59	protein kinase C zeta	Homo sapiens	22-29
28686226-4	2017	In DLBCL patients, overexpression of PCYT1A was in parallel with an increase in tumor MYC, as well as a decrease in serum choline metabolite phosphatidylcholine levels and an International Prognostic Index, indicating intermediate-high or high risk.	Phosphatidylcholines	141-160	phosphate cytidylyltransferase 1A, choline	Homo sapiens	37-43
28903399-0	2017	Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model.	Phosphatidylcholines	0-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
28903399-3	2017	We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells.	Phosphatidylcholines	28-47	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-122
28385694-3	2017	Phosphatidylcholine-transfer protein (PC-TP), which exchanges phosphatidylcholines among membranes, is enriched in hepatocytes.	Phosphatidylcholines	62-82	phosphatidylcholine transfer protein	Mus musculus	0-36
28385694-3	2017	Phosphatidylcholine-transfer protein (PC-TP), which exchanges phosphatidylcholines among membranes, is enriched in hepatocytes.	Phosphatidylcholines	62-82	phosphatidylcholine transfer protein	Mus musculus	38-43
28385694-12	2017	Our current observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets.	Phosphatidylcholines	109-129	phosphatidylcholine transfer protein	Mus musculus	38-43
28220208-6	2017	ABCB4 flops phosphatidylcholine into the outer leaflet of the membrane to be extracted by bile salts in the canalicular space.	Phosphatidylcholines	12-31	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
28434889-3	2017	Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine.	Phosphatidylcholines	89-108	transmembrane 6 superfamily member 2	Homo sapiens	14-20
28434889-3	2017	Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine.	Phosphatidylcholines	110-112	transmembrane 6 superfamily member 2	Homo sapiens	14-20
28373057-7	2017	Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC.	Phosphatidylcholines	154-173	LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7	Mesocricetus auratus	138-143
28373057-7	2017	Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC.	Phosphatidylcholines	154-173	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	245-250
28373057-7	2017	Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC.	Phosphatidylcholines	175-177	LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7	Mesocricetus auratus	138-143
28373057-7	2017	Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC.	Phosphatidylcholines	175-177	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	245-250
28373057-7	2017	Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC.	Phosphatidylcholines	184-186	LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7	Mesocricetus auratus	138-143
28642062-0	2017	LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/beta-catenin signaling in zebrafish.	Phosphatidylcholines	28-47	nuclear receptor subfamily 5, group A, member 2	Mus musculus	0-5
29450391-1	2017	Citicoline is the generic name of cytidine-5"-diphosphocholine (CDP-choline), an endogenous compound that is able to increase the levels of neurotransmitters in the central nervous system by interacting with the synthesis of cellular membranes phospholipids, especially phosphatidylcholine.	Phosphatidylcholines	270-289	cut like homeobox 1	Homo sapiens	64-67
28442572-9	2017	Finally, we demonstrated that CL activates the iPLA2gamma-mediated hydrolysis of arachidonic acid from phosphatidylcholine, thereby integrating the production of lipid messengers from different lipid classes in mitochondria.	Phosphatidylcholines	103-122	patatin-like phospholipase domain containing 8	Mus musculus	47-57
28642062-6	2017	Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development.	Phosphatidylcholines	84-103	nuclear receptor subfamily 5, group A, member 2	Mus musculus	43-48
28642062-6	2017	Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development.	Phosphatidylcholines	84-103	nuclear receptor subfamily 5, group A, member 2	Mus musculus	156-161
28642062-6	2017	Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development.	Phosphatidylcholines	105-107	nuclear receptor subfamily 5, group A, member 2	Mus musculus	43-48
28642062-6	2017	Screening the specific ligand(s) sensed by LRH-1 during organogenesis revealed that phosphatidylcholine (PC), a potential ligand, is the upstream target of LRH-1 during endoderm development.	Phosphatidylcholines	105-107	nuclear receptor subfamily 5, group A, member 2	Mus musculus	156-161
28494778-5	2017	To evaluate the mRNA and protein levels of lysophosphatidylcholine acyltransferase (LPCAT), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC), qRT-PCR, western blotting and immunohistochemistry were performed.	Phosphatidylcholines	47-66	lysophosphatidylcholine acyltransferase 1	Homo sapiens	84-89
28315318-0	2017	Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine.	Phosphatidylcholines	89-108	heparan sulfate proteoglycan 2	Homo sapiens	189-192
28315318-0	2017	Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine.	Phosphatidylcholines	135-154	heparan sulfate proteoglycan 2	Homo sapiens	189-192
28315318-0	2017	Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine.	Phosphatidylcholines	156-158	heparan sulfate proteoglycan 2	Homo sapiens	189-192
28315318-0	2017	Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine.	Phosphatidylcholines	186-188	heparan sulfate proteoglycan 2	Homo sapiens	189-192
28254415-7	2017	Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules.	Phosphatidylcholines	106-125	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	77-82
28420794-3	2017	Here the results of five independent techniques-surface plasmon resonance, electrochemical impedance spectroscopy, bilayer overtone analysis, neutron reflectometry, and molecular dynamics simulations-suggest that alpha-tubulin"s amphipathic helix H10 is responsible for peripheral binding of dimeric tubulin to biomimetic "mitochondrial" membranes in a manner that differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidylethanolamine and phosphatidylcholine.	Phosphatidylcholines	484-503	tubulin alpha 1b	Homo sapiens	213-226
28254415-7	2017	Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules.	Phosphatidylcholines	127-129	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	77-82
28423060-0	2017	Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells.	Phosphatidylcholines	0-19	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
28336574-2	2017	Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane.	Phosphatidylcholines	60-79	sphingomyelin synthase 2	Homo sapiens	119-130
28336574-2	2017	Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane.	Phosphatidylcholines	60-79	sphingomyelin synthase 1	Homo sapiens	132-137
28336574-2	2017	Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane.	Phosphatidylcholines	60-79	sphingomyelin synthase 2	Homo sapiens	155-159
28127842-2	2017	MDR3 mediates the translocation of phosphatidylcholine into bile.	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
28322795-1	2017	We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM).	Phosphatidylcholines	282-301	interferon regulatory factor 6	Homo sapiens	49-53
28322795-1	2017	We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM).	Phosphatidylcholines	303-305	interferon regulatory factor 6	Homo sapiens	49-53
28438206-9	2017	The increased amounts of phosphatidylcholine and surfactant protein B in the lamellar body fractions were decreased in the Ad-Rab38 infected lungs.	Phosphatidylcholines	25-44	RAB38, member RAS oncogene family	Rattus norvegicus	123-131
28401922-2	2017	Although the phospholipid transfer protein Stard7 promotes uptake of PC by mitochondria, the importance of this pathway for mitochondrial and cellular homeostasis represents a significant knowledge gap.	Phosphatidylcholines	69-71	START domain containing 7	Mus musculus	43-49
28401922-8	2017	These studies suggest that Stard7-mediated transfer of PC is crucial for mitochondrial homeostasis and that mitochondrial dysfunction contributes to altered barrier permeability in Stard7-deficient mice.	Phosphatidylcholines	55-57	START domain containing 7	Mus musculus	27-33
27614102-7	2017	RESULTS: Water vapour transmission rate demonstrated that as the phosphatidylcholine acyl chain length increased from C14, to C18, to C22, there was a corresponding increase in occlusive character.	Phosphatidylcholines	65-84	Bardet-Biedl syndrome 9	Homo sapiens	126-129
27693344-1	2017	It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 1	Homo sapiens	37-51
27693344-1	2017	It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 1	Homo sapiens	53-56
27693344-1	2017	It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 1	Homo sapiens	58-63
27693344-1	2017	It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	58-61
28177616-4	2017	Electrokinetic potential measurements of PI(4,5)P2 containing liposomes reveal that Ca2+ as well as Mg2+ reduce the zeta potential of liposomes to nearly background levels of pure phosphatidylcholine membranes.	Phosphatidylcholines	180-199	carbonic anhydrase 2	Homo sapiens	84-87
28291718-4	2017	Disruption of the methionine cycle in HCU has the potential to impact multiple aspect of phospholipid (PL) metabolism by disruption of both the Kennedy pathway and phosphatidylethanolamine N-methyltransferase (PEMT) mediated synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	238-257	phosphatidylethanolamine N-methyltransferase	Mus musculus	164-208
28291718-7	2017	A significant decrease in PC containing 20:4n6 which primarily formed by the methylation of phosphatidylethanolamine to PC was consistent with decreased flux through PEMT.	Phosphatidylcholines	26-28	phosphatidylethanolamine N-methyltransferase	Mus musculus	166-170
28225631-1	2017	C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site.	Phosphatidylcholines	86-105	C-reactive protein	Homo sapiens	0-18
28225631-1	2017	C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site.	Phosphatidylcholines	86-105	C-reactive protein	Homo sapiens	20-23
28087695-8	2017	[14C]Choline and [3H]palmitate tracking shows that SMS1 overexpression apparently affects the partitioning of palmitate-enriched diacylglycerol between the phosphatidylcholine and triacylglycerol pathways, to the benefit of the former.	Phosphatidylcholines	156-175	sphingomyelin synthase 1	Homo sapiens	51-55
28112912-3	2017	The MS2 fragments produced from protonated PC precursors and sodiated PC precursors were identified.	Phosphatidylcholines	43-45	MS2	Homo sapiens	4-7
28119456-8	2017	An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecies of phosphatidylcholine carrying very long polyunsaturated fatty acid chains.	Phosphatidylcholines	71-90	cell adhesion molecule 4	Homo sapiens	188-193
28119456-8	2017	An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecies of phosphatidylcholine carrying very long polyunsaturated fatty acid chains.	Phosphatidylcholines	255-274	cell adhesion molecule 4	Homo sapiens	188-193
28277942-5	2017	These factors include the Myosin V motor protein Myo2 involved in transporting vacuolar vesicles along actin cables, the transmembrane protein Atg9 involved in the recruitment of large precursor hydrolase complexes to the vacuole, the phosphatidylinositol/ phosphatidylcholine (PI/PC) transfer protein Sec 14 and the SNARE chaperone Sec 18.	Phosphatidylcholines	257-276	autophagy protein ATG9	Saccharomyces cerevisiae S288C	143-147
26803494-0	2017	Restrained Phosphatidylcholine Synthesis in a Cellular Model of Down"s Syndrome is Associated with the Overexpression of Dyrk1A.	Phosphatidylcholines	11-30	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	121-127
26803494-10	2017	Here, we explored the potential role of Dyrk1A in the reduction of phosphatidylcholine concentrations in trisomic cells in the presence of oleic acid.	Phosphatidylcholines	67-86	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	40-46
26803494-11	2017	The downregulation of Dyrk1A by small interfering RNA (siRNA) in trisomic cells returned phosphatidylcholine concentrations up to similar levels to those of euploid cells in the presence of oleic acid.	Phosphatidylcholines	89-108	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	22-28
26803494-12	2017	Thus, our results highlight the role of Dyrk1A in brain development through the modulation of phosphatidylcholine location, levels and synthesis.	Phosphatidylcholines	94-113	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	40-46
28012258-1	2017	ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion.	Phosphatidylcholines	155-174	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
28196124-4	2017	The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM.	Phosphatidylcholines	16-35	solute carrier family 38 member 3	Homo sapiens	123-127
28196124-4	2017	The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM.	Phosphatidylcholines	16-35	solute carrier family 38 member 5	Homo sapiens	132-136
28196124-4	2017	The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 muM.	Phosphatidylcholines	16-35	latexin	Homo sapiens	204-207
27769579-2	2017	Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	195-214	cut like homeobox 1	Homo sapiens	159-162
27769579-2	2017	Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	216-218	cut like homeobox 1	Homo sapiens	159-162
28012258-1	2017	ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion.	Phosphatidylcholines	155-174	ATP binding cassette subfamily B member 4	Homo sapiens	7-11
28012258-1	2017	ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion.	Phosphatidylcholines	176-178	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
28012258-1	2017	ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion.	Phosphatidylcholines	176-178	ATP binding cassette subfamily B member 4	Homo sapiens	7-11
29773019-2	2017	PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA).	Phosphatidylcholines	221-240	phospholipase A2 group IB	Homo sapiens	0-4
27913621-8	2017	Finally, we have provided in vivo evidence showing that activation of PPARdelta by agonist L165041 in mice increased hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	254-273	peroxisome proliferator activator receptor delta	Mus musculus	70-79
27760380-6	2017	ABCA1 dependent cholesterol efflux was higher than phosphatidylcholine efflux, was suppressed by probucol (ABCA1 inhibitor), AG490 (janus kinase-2 inhibitor), PD98059 (mitogen activated protein kinase kinase inhibitor) and pretreatment with beta-cyclodextrin (lowering membrane cholesterol).	Phosphatidylcholines	51-70	ATP binding cassette subfamily A member 1	Bos taurus	0-5
27760380-6	2017	ABCA1 dependent cholesterol efflux was higher than phosphatidylcholine efflux, was suppressed by probucol (ABCA1 inhibitor), AG490 (janus kinase-2 inhibitor), PD98059 (mitogen activated protein kinase kinase inhibitor) and pretreatment with beta-cyclodextrin (lowering membrane cholesterol).	Phosphatidylcholines	51-70	Janus kinase 2	Bos taurus	132-146
28001010-5	2017	RESULTS: LBP gene expression was negatively associated with phosphatidylcholine, phosphatidylserine, and sphingomyelin relative abundance in vivo.	Phosphatidylcholines	60-79	lipopolysaccharide binding protein	Homo sapiens	9-12
28127382-4	2017	RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM).	Phosphatidylcholines	118-137	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	30-34
28127382-4	2017	RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM).	Phosphatidylcholines	139-141	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	30-34
27894770-2	2017	Three fluorogenic phosphatidylcholine analogs PC-1, PC-2, and PC-3 each containing the duo of 7-mercapto-4-methyl-coumarin fluorophore and 2,4-dinitroanaline quencher on either tail were synthesized from (R)-3-amino-1,2-propanediol and R-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol.	Phosphatidylcholines	18-37	polycystin 1, transient receptor potential channel interacting	Homo sapiens	46-50
27645136-2	2016	It confers freezing tolerance in transgenic Arabidopsis, possibly by its interaction with lipids as indicated by the binding of acyl-CoA esters and phosphatidylcholine to recombinant AtACBP6.	Phosphatidylcholines	148-167	acyl-CoA-binding protein 6	Arabidopsis thaliana	183-190
27591999-0	2016	Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice.	Phosphatidylcholines	95-114	arsenite methyltransferase	Mus musculus	12-58
27256568-0	2017	Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.	Phosphatidylcholines	9-28	NLR family, pyrin domain containing 3	Mus musculus	55-60
27256568-4	2017	In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta.	Phosphatidylcholines	48-67	NLR family, pyrin domain containing 3	Mus musculus	94-99
27256568-4	2017	In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta.	Phosphatidylcholines	48-67	interleukin 1 beta	Mus musculus	157-165
27256568-9	2017	Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages.	Phosphatidylcholines	60-80	NLR family, pyrin domain containing 3	Mus musculus	120-125
27256568-9	2017	Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages.	Phosphatidylcholines	60-80	interleukin 1 beta	Mus musculus	169-177
28683445-2	2017	Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) and thereby can regulate intracellular free-AA levels.	Phosphatidylcholines	35-54	lysophosphatidylcholine acyltransferase 3	Homo sapiens	74-80
28683445-2	2017	Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) and thereby can regulate intracellular free-AA levels.	Phosphatidylcholines	75-77	lysophosphatidylcholine acyltransferase 3	Homo sapiens	31-72
27595588-3	2017	Here we show that PC biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PAH.	Phosphatidylcholines	18-20	cell division control 2	Arabidopsis thaliana	94-121
27595588-3	2017	Here we show that PC biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PAH.	Phosphatidylcholines	18-20	cell division control 2	Arabidopsis thaliana	123-129
27595588-5	2017	Expression of a CDK-insensitive version of PAH1 with a serine 162 to alanine substitution represses PC biosynthesis and also reduces the rate of cell division in early leaf development.	Phosphatidylcholines	100-102	cell division control 2	Arabidopsis thaliana	16-19
27595588-5	2017	Expression of a CDK-insensitive version of PAH1 with a serine 162 to alanine substitution represses PC biosynthesis and also reduces the rate of cell division in early leaf development.	Phosphatidylcholines	100-102	Lipin family protein	Arabidopsis thaliana	43-47
27502364-2	2016	B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions.	Phosphatidylcholines	214-220	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	28-73
27502364-2	2016	B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions.	Phosphatidylcholines	214-220	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	75-83
27723344-3	2016	Using microsecond-long molecular dynamics simulations, we analyzed interaction of CYP3A4 with bilayers composed of lipids differing in their polar head groups, i.e., phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol.	Phosphatidylcholines	166-185	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
27694445-0	2016	StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria.	Phosphatidylcholines	48-67	START domain containing 7	Mus musculus	0-6
27694445-3	2016	In a previous study, we found that StarD7 mediates the intracellular transfer of PC to mitochondria.	Phosphatidylcholines	81-83	START domain containing 7	Mus musculus	35-41
27883027-3	2016	NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC).	Phosphatidylcholines	73-92	patatin like phospholipase domain containing 6	Gallus gallus	0-3
27883027-3	2016	NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC).	Phosphatidylcholines	94-96	patatin like phospholipase domain containing 6	Gallus gallus	0-3
27746179-3	2016	By the mass spectrometry analysis, we demonstrate that Yor022c is actually a phospholipase displaying sn-1-specific activity toward phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid, generating 2-acyl lysophospholipids.	Phosphatidylcholines	132-151	putative carboxylic ester hydrolase	Saccharomyces cerevisiae S288C	55-62
27575989-3	2016	In the present study, we aimed to evaluate the putative protective effect of PC on carbon tetrachloride (CCl4)-induced nephrotoxicity in ICR mice.	Phosphatidylcholines	77-79	chemokine (C-C motif) ligand 4	Mus musculus	105-109
27575989-8	2016	Comparative analysis of histopathological injuries revealed that PC abrogated the nephrotoxicity of CCl4 at 7 days.	Phosphatidylcholines	65-67	chemokine (C-C motif) ligand 4	Mus musculus	100-104
27575989-9	2016	Accordingly, PC also improved renal fibrosis induced by CCl4.	Phosphatidylcholines	13-15	chemokine (C-C motif) ligand 4	Mus musculus	56-60
27575989-13	2016	These results strongly suggest that PC can protect against oxidative damage induced by CCl4 in the kidney and enhance recovery from renal disorders.	Phosphatidylcholines	36-38	chemokine (C-C motif) ligand 4	Mus musculus	87-91
26567110-4	2016	This study originally describes that lysophosphatidylcholine (LPtdCho), either exogenously supplied or generated by the imbalance of PtdCho metabolism through the enzymatic action of cytosolic phospholipase A2, acts as a neurotrophic-like factor.	Phosphatidylcholines	63-69	phospholipase A2 group IVA	Homo sapiens	183-209
27554972-2	2016	StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis.	Phosphatidylcholines	35-54	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
27731369-4	2016	PGP inactivation attenuated triosephosphate isomerase activity, increased triglyceride levels at the expense of the cellular phosphatidylcholine content, and inhibited cell proliferation.	Phosphatidylcholines	125-144	phosphoglycolate phosphatase	Mus musculus	0-3
27436233-7	2016	Overexpression of SDC1 in planta increased levels of ethanolamine, phosphatidylethanolamine, and phosphatidylcholine both in leaves and siliques.	Phosphatidylcholines	97-116	Pyridoxal phosphate (PLP)-dependent transferases superfamily protein	Arabidopsis thaliana	18-22
27666314-1	2016	The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system.	Phosphatidylcholines	133-152	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44
27666314-1	2016	The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system.	Phosphatidylcholines	133-152	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
27666314-1	2016	The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system.	Phosphatidylcholines	154-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44
27666314-1	2016	The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system.	Phosphatidylcholines	154-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	256-275	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	53-92
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	256-275	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	94-97
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	256-275	cut-like homeobox 1	Rattus norvegicus	183-186
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	277-279	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	53-92
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	277-279	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	94-97
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	277-279	cut-like homeobox 1	Rattus norvegicus	183-186
27457520-4	2016	Cho phosphotransferase CHPT1, identified as a direct ERalpha-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis.	Phosphatidylcholines	158-177	choline phosphotransferase 1	Danio rerio	23-28
27457520-4	2016	Cho phosphotransferase CHPT1, identified as a direct ERalpha-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis.	Phosphatidylcholines	158-177	estrogen receptor 1	Danio rerio	53-60
27554972-2	2016	StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis.	Phosphatidylcholines	56-58	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
27554972-3	2016	Since inhibition of PC synthesis may lead to endoplasmic reticulum (ER) stress we hypothesized that StarD7 may be involved in maintaining cell homeostasis.	Phosphatidylcholines	20-22	StAR related lipid transfer domain containing 7	Homo sapiens	100-106
27436846-1	2016	RATIONALE: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL).	Phosphatidylcholines	72-91	apolipoprotein A1	Homo sapiens	25-43
27713745-0	2016	Phosphocholine-Specific Antibodies Improve T-Dependent Antibody Responses against OVA Encapsulated into Phosphatidylcholine-Containing Liposomes.	Phosphatidylcholines	104-123	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	82-85
27611931-1	2016	Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG).	Phosphatidylcholines	188-207	monoacylglycerol O-acyltransferase 1	Homo sapiens	0-34
27611931-1	2016	Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG).	Phosphatidylcholines	188-207	monoacylglycerol O-acyltransferase 1	Homo sapiens	36-42
27402832-10	2016	Instead, the dynamic TIM23 complex is destabilized when the PC levels are reduced, whereas the TIM22 complex remains intact.	Phosphatidylcholines	60-62	translocase of inner mitochondrial membrane 23	Homo sapiens	21-26
27402832-12	2016	We conclude that reduced PC levels differentially affect the TIM22 and TIM23 complexes in mitochondrial protein transport.	Phosphatidylcholines	25-27	translocase of inner mitochondrial membrane 22	Homo sapiens	61-66
27402832-12	2016	We conclude that reduced PC levels differentially affect the TIM22 and TIM23 complexes in mitochondrial protein transport.	Phosphatidylcholines	25-27	translocase of inner mitochondrial membrane 23	Homo sapiens	71-76
27436846-1	2016	RATIONALE: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL).	Phosphatidylcholines	72-91	apolipoprotein A1	Homo sapiens	45-51
27317427-6	2016	Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine.	Phosphatidylcholines	85-104	phospholipase A2 group VI	Homo sapiens	13-19
27317427-6	2016	Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine.	Phosphatidylcholines	85-104	patatin like phospholipase domain containing 6	Homo sapiens	21-27
27317427-6	2016	Knockdown of PNPLA9, PNPLA6 or PNPLA4 significantly (30-50%) reduced the turnover of phosphatidylcholine, -ethanolamine and -serine.	Phosphatidylcholines	85-104	patatin like phospholipase domain containing 4	Homo sapiens	31-37
26721598-6	2016	We will show that oxidative modifications of PL by HOCl have a considerable impact on the PLA2 digestibility, i.e., oxidation of the unsaturated fatty acyl residues leads to a reduced digestibility of both PC and PE.	Phosphatidylcholines	206-208	phospholipase A2 group IB	Homo sapiens	90-94
27574784-9	2016	Desorption electrospray ionization mass spectrometry (DESI MS)-based imaging of cell lines and tumor tissues revealed changes in phosphatidylcholines levels upon treatment.	Phosphatidylcholines	129-149	desumoylating isopeptidase 2	Homo sapiens	54-58
26961241-5	2016	The POPC conjugate of the NS5B inhibitors was assumed to result from two sequential reactions: hydroxylation of the bicyclic methine to a tertiary alcohol and addition of POPC by CDP-choline: 1,2-diacylglycerol cholinephosphotransferase, an enzyme responsible for the final step in the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	302-321	cut like homeobox 1	Homo sapiens	179-182
27347790-0	2016	Effect of Cholesterol on the Interaction of Cytochrome P450 Substrate Drug Chlorzoxazone with the Phosphatidylcholine Bilayer.	Phosphatidylcholines	98-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59
27347790-6	2016	In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction.	Phosphatidylcholines	154-173	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-83
27347790-6	2016	In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction.	Phosphatidylcholines	175-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-83
27193303-0	2016	Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins.	Phosphatidylcholines	150-169	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	114-119
27193303-4	2016	Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis.	Phosphatidylcholines	124-143	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	41-46
27193303-4	2016	Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis.	Phosphatidylcholines	124-143	Sec14p-like phosphatidylinositol transfer family protein	Arabidopsis thaliana	52-58
27193303-4	2016	Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis.	Phosphatidylcholines	145-151	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	41-46
27009527-1	2016	The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation.	Phosphatidylcholines	113-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	160-175
27009527-1	2016	The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation.	Phosphatidylcholines	113-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	177-180
27009527-1	2016	The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation.	Phosphatidylcholines	134-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	160-175
27009527-1	2016	The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation.	Phosphatidylcholines	134-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	177-180
27009527-7	2016	Binding assays revealed that PLD re-localized from the aqueous phase to the solvent-buffer interface, where the enzymatic reaction takes place, in the presence of both, the salt and PC.	Phosphatidylcholines	182-184	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-32
27581838-2	2016	Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism.	Phosphatidylcholines	93-112	phospholipid transfer protein	Homo sapiens	0-29
27581838-2	2016	Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism.	Phosphatidylcholines	93-112	phospholipid transfer protein	Homo sapiens	31-35
27581838-2	2016	Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism.	Phosphatidylcholines	93-112	lecithin-cholesterol acyltransferase	Homo sapiens	41-77
27581838-2	2016	Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism.	Phosphatidylcholines	93-112	lecithin-cholesterol acyltransferase	Homo sapiens	79-83
27246581-5	2016	We also show that in addition to phosphatidylcholine alteration, there is also an effect in the ratio of phosphatidylcholine/phosphatidylethanolamine in serum of mice induced with the disease and that this change may be due to increased expression of the phosphatidylethanolamine N-methyltransferase gene.	Phosphatidylcholines	105-124	phosphatidylethanolamine N-methyltransferase	Mus musculus	255-299
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	13-32	lipase H	Homo sapiens	82-98
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	13-32	lipase H	Homo sapiens	100-104
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	34-36	lipase H	Homo sapiens	82-98
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	34-36	lipase H	Homo sapiens	100-104
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	139-141	lipase H	Homo sapiens	82-98
27108109-1	2016	DHA/EPA-rich phosphatidylcholine (PC) was successfully synthesized by immobilized phospholipase A1 (PLA1)-catalyzed transesterification of PC and DHA/EPA-rich ethyl esters in a solvent-free system.	Phosphatidylcholines	139-141	lipase H	Homo sapiens	100-104
27403735-3	2016	Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively.	Phosphatidylcholines	178-197	diacylglycerol kinase beta	Homo sapiens	204-207
27403735-3	2016	Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively.	Phosphatidylcholines	178-197	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	212-215
27403735-3	2016	Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively.	Phosphatidylcholines	199-201	diacylglycerol kinase beta	Homo sapiens	204-207
27403735-3	2016	Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively.	Phosphatidylcholines	199-201	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	212-215
27193303-4	2016	Here we demonstrate that, like the yeast Sec14, the AtSfh1 PITP domain requires both its phosphatidylinositol (PtdIns)- and phosphatidylcholine (PtdCho)-binding properties to stimulate PtdIns-4-phosphate [PtdIns(4)P] synthesis.	Phosphatidylcholines	145-151	Sec14p-like phosphatidylinositol transfer family protein	Arabidopsis thaliana	52-58
27383786-8	2016	This is explained by an increase in microsomal phospholipids containing polyunsaturated fatty acids, linked to an LXRalpha-dependent increase in expression of enzymes mediating phosphatidylcholine biosynthesis and incorporation of polyunsaturated fatty acids into phospholipids.	Phosphatidylcholines	177-196	nuclear receptor subfamily 1, group H, member 3	Mus musculus	114-122
27320911-3	2016	SREBPs can be regulated in response to membrane cholesterol and we also found that low levels of phosphatidylcholine (a methylated phospholipid) led to SBP-1/SREBP-1 maturation in C. elegans or mammalian models.	Phosphatidylcholines	97-116	BHLH domain-containing protein	Caenorhabditis elegans	152-157
27165857-2	2016	Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS) 1 in the Golgi and SMS2 at the plasma membrane.	Phosphatidylcholines	60-79	sphingomyelin synthase 1	Homo sapiens	119-138
27165857-2	2016	Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS) 1 in the Golgi and SMS2 at the plasma membrane.	Phosphatidylcholines	60-79	sphingomyelin synthase 2	Homo sapiens	156-160
27073147-2	2016	Choline kinase alpha (ChoKalpha) is a key mediator of these changes, as it represents the first committed step in the Kennedy pathway of phosphatidylcholine biosynthesis and ChoKalpha expression is upregulated in many human cancers.	Phosphatidylcholines	137-156	choline kinase alpha	Homo sapiens	0-20
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	103-122	ATPase phospholipid transporting 10A (putative)	Homo sapiens	38-44
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	103-122	ATPase phospholipid transporting 8B1	Homo sapiens	45-51
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	103-122	ATPase phospholipid transporting 11A	Homo sapiens	57-63
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	103-122	ATPase phospholipid transporting 11C	Homo sapiens	64-70
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	124-126	ATPase phospholipid transporting 10A (putative)	Homo sapiens	38-44
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	124-126	ATPase phospholipid transporting 8B1	Homo sapiens	45-51
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	124-126	ATPase phospholipid transporting 11A	Homo sapiens	57-63
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylcholines	124-126	ATPase phospholipid transporting 11C	Homo sapiens	64-70
27112167-7	2016	The antifungal azoles, posaconazole, itraconazole, and ketoconazole, significantly inhibited MDR3-mediated phosphatidylcholine secretion.	Phosphatidylcholines	107-126	ATP binding cassette subfamily B member 4	Homo sapiens	93-97
27320911-3	2016	SREBPs can be regulated in response to membrane cholesterol and we also found that low levels of phosphatidylcholine (a methylated phospholipid) led to SBP-1/SREBP-1 maturation in C. elegans or mammalian models.	Phosphatidylcholines	97-116	sterol regulatory element binding transcription factor 1	Homo sapiens	158-165
27032901-0	2016	Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans.	Phosphatidylcholines	16-35	insulin	Homo sapiens	80-87
27206796-2	2016	Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 muM and inhibited tumor xenograft growth in mice.	Phosphatidylcholines	71-90	choline kinase alpha	Mus musculus	14-34
27206796-2	2016	Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 muM and inhibited tumor xenograft growth in mice.	Phosphatidylcholines	71-90	choline kinase alpha	Mus musculus	36-40
27282246-1	2016	Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC).	Phosphatidylcholines	85-104	phospholipase A2, group IB, pancreas	Mus musculus	0-16
27282246-1	2016	Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC).	Phosphatidylcholines	85-104	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	18-23
27282246-1	2016	Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC).	Phosphatidylcholines	106-108	phospholipase A2, group IB, pancreas	Mus musculus	0-16
27282246-1	2016	Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC).	Phosphatidylcholines	106-108	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	18-23
27058440-3	2016	PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline.	Phosphatidylcholines	32-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
27058440-3	2016	PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline.	Phosphatidylcholines	54-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
27256251-1	2016	Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	174-193	ATP binding cassette subfamily B member 4	Homo sapiens	0-22
27256251-1	2016	Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	174-193	ATP binding cassette subfamily B member 4	Homo sapiens	24-28
27256251-1	2016	Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	174-193	ATP binding cassette subfamily B member 4	Homo sapiens	46-89
27256251-1	2016	Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	174-193	ATP binding cassette subfamily B member 4	Homo sapiens	96-101
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase D2	Homo sapiens	0-16
27149373-1	2016	Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	87-106	choline kinase beta	Homo sapiens	0-19
27149373-1	2016	Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	87-106	creatine kinase B	Homo sapiens	21-27
26873001-0	2016	Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia.	Phosphatidylcholines	53-72	carbonic anhydrase 1	Rattus norvegicus	92-95
26873001-7	2016	IMS detected significant molecular changes after TGI in the same CA1 domain: increase of PC (diacyl-16:0/22:6) in the superacute phase and increase of PC (diacyl-16:0/18:1) in the subacute to chronic phases.	Phosphatidylcholines	89-91	carbonic anhydrase 1	Rattus norvegicus	65-68
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase D2	Homo sapiens	18-22
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	165-167	phospholipase D2	Homo sapiens	0-16
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	165-167	phospholipase D2	Homo sapiens	18-22
26454209-3	2016	Here we tested the ability of reconstituted HDL (rHDL) consisting of human apoA-I reconstituted with soy phosphatidylcholine for its ability to lower amyloid beta (Abeta) levels in symptomatic APP/PS1 mice, a well-characterized preclinical model of amyloidosis.	Phosphatidylcholines	105-124	amyloid beta precursor protein	Homo sapiens	150-162
26454209-3	2016	Here we tested the ability of reconstituted HDL (rHDL) consisting of human apoA-I reconstituted with soy phosphatidylcholine for its ability to lower amyloid beta (Abeta) levels in symptomatic APP/PS1 mice, a well-characterized preclinical model of amyloidosis.	Phosphatidylcholines	105-124	amyloid beta precursor protein	Homo sapiens	164-169
26797396-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
27110687-2	2016	The current study tested the possibility that increased expression of lysophosphatidylcholine acyltransferase-3 (LPCAT3), an enzyme that converts lysophosphatidylcholine to phosphatidylcholine in the liver, may alleviate the adverse effects of lysophospholipids absorbed after a lipid-glucose mixed meal.	Phosphatidylcholines	74-93	lysophosphatidylcholine acyltransferase 3	Mus musculus	113-119
26907692-8	2016	Depletion of LB PRDX6 in AP-3- or LIMP-2/SCARB2-deficient mice correlates with phospholipid accumulation in lamellar bodies and with defective intraluminal degradation of LB disaturated phosphatidylcholine.	Phosphatidylcholines	186-205	peroxiredoxin 6	Mus musculus	16-21
26651393-0	2016	Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation.	Phosphatidylcholines	10-29	cholinergic receptor nicotinic alpha 7 subunit	Homo sapiens	98-104
26921317-3	2016	We propose that Prdx6 LB targeting facilitates its role in the metabolism of lung surfactant phosphatidylcholine (PC).	Phosphatidylcholines	93-112	peroxiredoxin 6	Mus musculus	16-21
26921317-3	2016	We propose that Prdx6 LB targeting facilitates its role in the metabolism of lung surfactant phosphatidylcholine (PC).	Phosphatidylcholines	114-116	peroxiredoxin 6	Mus musculus	16-21
26921317-8	2016	The content of total phospholipid, PC, and disaturated PC in lung tissue homogenate, bronchoalveolar lavage fluid, and lung LB was increased significantly in Prdx6-S32T mutant lungs, whereas degradation of internalized [(3)H]dipalmitoyl-PC was significantly decreased.	Phosphatidylcholines	35-37	peroxiredoxin 6	Mus musculus	158-163
26921317-10	2016	These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine.	Phosphatidylcholines	106-125	peroxiredoxin 6	Mus musculus	47-52
26797396-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
26797396-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
26797396-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
26821209-7	2016	Reduced membrane level of PKCepsilon and PKCdelta was associated with significant incorporation of DHA in all phospholipids, including phosphatidylcholine which is a major source of phosphatidic acid.	Phosphatidylcholines	135-154	protein kinase C delta	Homo sapiens	41-49
26830860-6	2016	A linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that LPC generated by Prdx6 PLA2activity remained bound to the enzyme for the reacylation reaction.	Phosphatidylcholines	87-89	peroxiredoxin 6	Mus musculus	123-128
26828064-1	2016	Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylcholine remodeling in the small intestine and liver.	Phosphatidylcholines	4-23	lysophosphatidylcholine acyltransferase 3	Mus musculus	43-49
26821209-7	2016	Reduced membrane level of PKCepsilon and PKCdelta was associated with significant incorporation of DHA in all phospholipids, including phosphatidylcholine which is a major source of phosphatidic acid.	Phosphatidylcholines	135-154	protein kinase C epsilon	Homo sapiens	26-36
26830860-6	2016	A linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that LPC generated by Prdx6 PLA2activity remained bound to the enzyme for the reacylation reaction.	Phosphatidylcholines	87-89	phospholipase A2, group V	Mus musculus	129-133
26921357-6	2016	Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins.	Phosphatidylcholines	177-196	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	22-27
26921357-6	2016	Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins.	Phosphatidylcholines	177-196	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	136-141
26921357-6	2016	Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins.	Phosphatidylcholines	198-204	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	22-27
26921357-6	2016	Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins.	Phosphatidylcholines	198-204	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	136-141
26830860-8	2016	Thus, Prdx6 is a complete enzyme comprising both PLA2and LPCAT activities for the remodeling pathway of PC synthesis or for repair of membrane lipid peroxidation.	Phosphatidylcholines	58-60	peroxiredoxin 6	Mus musculus	6-11
26381674-0	2016	Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth.	Phosphatidylcholines	84-103	scavenger receptor class B member 1	Homo sapiens	45-49
26566624-3	2016	In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS).	Phosphatidylcholines	46-65	serpin family B member 3	Homo sapiens	165-168
26566624-3	2016	In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS).	Phosphatidylcholines	67-69	serpin family B member 3	Homo sapiens	165-168
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	162-181	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	61-70
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	162-181	interleukin 1 beta	Homo sapiens	85-93
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	183-185	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	61-70
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	183-185	interleukin 1 beta	Homo sapiens	85-93
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	216-218	interleukin 1 beta	Homo sapiens	85-93
26773402-5	2016	RESULTS: Phosphatidylcholines, when expressed as the relative amount compared with total phospholipids and sphingolipids, were similar in both HDL2 and HDL3 in the two groups.	Phosphatidylcholines	9-29	junctophilin 3	Homo sapiens	143-147
26773402-5	2016	RESULTS: Phosphatidylcholines, when expressed as the relative amount compared with total phospholipids and sphingolipids, were similar in both HDL2 and HDL3 in the two groups.	Phosphatidylcholines	9-29	HDL3	Homo sapiens	152-156
26936140-7	2016	Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism.	Phosphatidylcholines	25-27	interleukin 2	Rattus norvegicus	131-135
26936140-7	2016	Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism.	Phosphatidylcholines	25-27	Cd28 molecule	Rattus norvegicus	183-187
26936140-7	2016	Increasing the supply of PC in the form of lysophosphatidylcholine to splenocytes in vitro increased the rate of proliferation and IL-2 production and the surface expression of CD25, CD28, CD71, and CD152 on CD8+ T cells, suggesting 1 possible mechanism.	Phosphatidylcholines	25-27	cytotoxic T-lymphocyte-associated protein 4	Rattus norvegicus	199-204
26381674-6	2016	Trafficking of a fluorescent phosphatidylcholine analogue to Chlamydia was blocked by the inhibition of CLA1 or ABCA1 function, indicating a critical role for these transporters in phosphatidylcholine acquisition by this organism.	Phosphatidylcholines	29-48	scavenger receptor class B member 1	Homo sapiens	104-108
26381674-6	2016	Trafficking of a fluorescent phosphatidylcholine analogue to Chlamydia was blocked by the inhibition of CLA1 or ABCA1 function, indicating a critical role for these transporters in phosphatidylcholine acquisition by this organism.	Phosphatidylcholines	181-200	scavenger receptor class B member 1	Homo sapiens	104-108
26807595-3	2016	Longer-chain phosphatidylcholine lipids, which form the lining of milk ducts and milk fat globules, enhanced RCM kappa-casein fibril formation irrespective of whether the lipids were in a monomeric or micellar state, whereas shorter-chain phospholipids and triglycerides had little effect.	Phosphatidylcholines	13-32	casein kappa	Homo sapiens	113-125
26880640-3	2016	The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), a retinol-related enzyme that transfers an acyl group derived from an sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	209-228	lecithin retinol acyltransferase	Homo sapiens	81-113
26880640-3	2016	The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), a retinol-related enzyme that transfers an acyl group derived from an sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	209-228	lecithin retinol acyltransferase	Homo sapiens	115-119
26620528-0	2016	ALA10, a Phospholipid Flippase, Controls FAD2/FAD3 Desaturation of Phosphatidylcholine in the ER and Affects Chloroplast Lipid Composition in Arabidopsis thaliana.	Phosphatidylcholines	67-86	fatty acid desaturase 2	Arabidopsis thaliana	41-45
26620528-0	2016	ALA10, a Phospholipid Flippase, Controls FAD2/FAD3 Desaturation of Phosphatidylcholine in the ER and Affects Chloroplast Lipid Composition in Arabidopsis thaliana.	Phosphatidylcholines	67-86	fatty acid desaturase 3	Arabidopsis thaliana	46-50
26620528-5	2016	ALA10 interacts also with FATTY ACID DESATURASE2 (FAD2), and modification of ALA10 expression affects phosphatidylcholine (PC) fatty acyl desaturation by disturbing the balance between FAD2 and FAD3 activities.	Phosphatidylcholines	102-121	fatty acid desaturase 2	Arabidopsis thaliana	185-189
26620528-5	2016	ALA10 interacts also with FATTY ACID DESATURASE2 (FAD2), and modification of ALA10 expression affects phosphatidylcholine (PC) fatty acyl desaturation by disturbing the balance between FAD2 and FAD3 activities.	Phosphatidylcholines	102-121	fatty acid desaturase 3	Arabidopsis thaliana	194-198
26900700-1	2016	Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 4	Homo sapiens	0-30
26900700-1	2016	Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 4	Homo sapiens	32-36
26900700-1	2016	Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 4	Homo sapiens	38-43
26887851-8	2016	When repeated on the isogenic strain deleted in OPI1, encoding for a transcriptional repressor of genes involved in PC biosynthesis, FTIR analysis revealed that not only the PC levels were affected but also the cell membrane/wall composition and the accumulation of protein aggregates, resulting in higher growth rate in the presence of the stressing agent.	Phosphatidylcholines	116-118	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	48-52
26883475-4	2016	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth.	Phosphatidylcholines	59-78	phospholipase D1	Homo sapiens	0-16
26883475-4	2016	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth.	Phosphatidylcholines	59-78	phospholipase D1	Homo sapiens	18-22
26888014-3	2016	Here, we report that ENPP6, a choline-specific phosphodiesterase, hydrolyzes glycerophosphocholine (GPC), a degradation product of PC, as a physiological substrate and participates in choline metabolism.	Phosphatidylcholines	101-103	ectonucleotide pyrophosphatase/phosphodiesterase 6	Mus musculus	21-26
26883475-4	2016	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth.	Phosphatidylcholines	80-82	phospholipase D1	Homo sapiens	0-16
26888014-4	2016	ENPP6 is highly expressed in liver sinusoidal endothelial cells and developing oligodendrocytes, which actively incorporate choline and synthesize PC.	Phosphatidylcholines	147-149	ectonucleotide pyrophosphatase/phosphodiesterase 6	Mus musculus	0-5
26883475-4	2016	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth.	Phosphatidylcholines	80-82	phospholipase D1	Homo sapiens	18-22
26888014-6	2016	The choline moiety of GPC was incorporated into PC in an ENPP6-dependent manner both in vivo and in vitro.	Phosphatidylcholines	23-25	ectonucleotide pyrophosphatase/phosphodiesterase 6	Mus musculus	57-62
25316339-0	2016	Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.	Phosphatidylcholines	76-95	tachykinin 1	Mus musculus	0-11
25752890-4	2016	Protein expression of lysophosphatidylcholine acyltransferase 1 (LPCAT1), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) in the presence of acyl-CoA in Lands" cycle, was immunohistochemically analyzed in 182 gastric cancer specimens.	Phosphatidylcholines	26-45	lysophosphatidylcholine acyltransferase 1	Homo sapiens	65-71
25752890-4	2016	Protein expression of lysophosphatidylcholine acyltransferase 1 (LPCAT1), which converts lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) in the presence of acyl-CoA in Lands" cycle, was immunohistochemically analyzed in 182 gastric cancer specimens.	Phosphatidylcholines	66-68	lysophosphatidylcholine acyltransferase 1	Homo sapiens	22-63
26603903-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	94-113	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
26603903-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	94-113	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
26603903-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	115-117	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
26603903-1	2016	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	115-117	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
25316339-0	2016	Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.	Phosphatidylcholines	76-95	nitric oxide synthase 1, neuronal	Mus musculus	142-146
26756862-0	2016	Impact of phosphatidylcholine liposomes on the compositional changes of VLDL during lipoprotein lipase (LPL)-mediated lipolysis.	Phosphatidylcholines	10-29	lipoprotein lipase	Homo sapiens	84-102
26756862-0	2016	Impact of phosphatidylcholine liposomes on the compositional changes of VLDL during lipoprotein lipase (LPL)-mediated lipolysis.	Phosphatidylcholines	10-29	lipoprotein lipase	Homo sapiens	104-107
26267291-6	2016	This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion.	Phosphatidylcholines	227-229	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	120-150
25283521-1	2016	Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation.	Phosphatidylcholines	143-162	ATP binding cassette subfamily B member 4	Rattus norvegicus	0-30
25283521-1	2016	Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation.	Phosphatidylcholines	143-162	ATP binding cassette subfamily B member 4	Rattus norvegicus	32-36
25283521-1	2016	Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation.	Phosphatidylcholines	143-162	ATP binding cassette subfamily B member 4	Rattus norvegicus	50-73
25283521-1	2016	Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation.	Phosphatidylcholines	143-162	ATP binding cassette subfamily B member 4	Rattus norvegicus	75-80
26172874-11	2016	CONCLUSION: Inhibition of ASBT reduces BA pool size and retention of hydrophobic BA, favorably alters the biliary PC/BA ratio, profoundly changes the hepatic transcriptome, attenuates recruitment of leukocytes, and abrogates progression of murine sclerosing cholangitis.	Phosphatidylcholines	114-116	solute carrier family 10, member 2	Mus musculus	26-30
26153658-1	2016	BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects.	Phosphatidylcholines	96-115	ATP binding cassette subfamily B member 4	Homo sapiens	46-51
26153658-1	2016	BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects.	Phosphatidylcholines	96-115	ATP binding cassette subfamily B member 4	Homo sapiens	116-120
26153658-10	2016	Phosphatidylcholine efflux activity was decreased to 56-18% of reference levels for MDR3 mutants T175A, A250T and S320F.	Phosphatidylcholines	0-19	ATP binding cassette subfamily B member 4	Homo sapiens	84-88
26212962-0	2016	Phospholipase A1-catalyzed hydrolysis of soy phosphatidylcholine to prepare l-alpha-glycerylphosphorylcholine in organic-aqueous media.	Phosphatidylcholines	45-64	lipase H	Homo sapiens	0-16
26212962-1	2016	This study aimed to optimize the preparation of L-alpha-glycerylphosphorylcholine (l-alpha-GPC) via phospholipase A1 (Lecitase Ultra)-catalyzed hydrolysis of soy phosphatidylcholine (PC).	Phosphatidylcholines	162-181	lipase H	Homo sapiens	100-116
26212962-1	2016	This study aimed to optimize the preparation of L-alpha-glycerylphosphorylcholine (l-alpha-GPC) via phospholipase A1 (Lecitase Ultra)-catalyzed hydrolysis of soy phosphatidylcholine (PC).	Phosphatidylcholines	92-94	lipase H	Homo sapiens	100-116
26267291-2	2016	Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1).	Phosphatidylcholines	82-102	nuclear receptor subfamily 5, group A, member 2	Mus musculus	144-168
26267291-2	2016	Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1).	Phosphatidylcholines	82-102	nuclear receptor subfamily 5, group A, member 2	Mus musculus	170-175
26267291-2	2016	Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1).	Phosphatidylcholines	104-107	nuclear receptor subfamily 5, group A, member 2	Mus musculus	144-168
26267291-2	2016	Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog-1 (LRH-1).	Phosphatidylcholines	104-107	nuclear receptor subfamily 5, group A, member 2	Mus musculus	170-175
26212931-6	2016	Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels.	Phosphatidylcholines	45-64	vascular endothelial growth factor A	Homo sapiens	132-136
26212931-6	2016	Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels.	Phosphatidylcholines	45-64	angiopoietin 2	Homo sapiens	141-155
26212931-6	2016	Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels.	Phosphatidylcholines	45-64	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
26789121-1	2016	ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes.	Phosphatidylcholines	65-84	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
26789121-1	2016	ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes.	Phosphatidylcholines	65-84	ATP binding cassette subfamily B member 4	Homo sapiens	6-10
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	117-136	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-22
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	117-136	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	24-28
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	117-136	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	43-85
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	117-136	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	87-92
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	138-140	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-22
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	138-140	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	24-28
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	138-140	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	43-85
26542370-1	2016	Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation.	Phosphatidylcholines	138-140	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	87-92
26267291-6	2016	This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion.	Phosphatidylcholines	227-229	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	152-156
26267291-6	2016	This includes reduced expression of the highly active glycine-n-methyltransferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting in reduced consumption of methyl groups and biliary PC secretion.	Phosphatidylcholines	227-229	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	157-162
26836186-8	2016	Further phosphatidylcholine species (34:6, 36:5, 40:6) correlated with cerebrospinal fluid tau (p <  0.05), and plasmalogen ethanolamine species (34:2, 36:,4) correlated with both cerebrospinal fluid tau and brain amyloid load within the MC group (p <  0.05).	Phosphatidylcholines	8-27	microtubule associated protein tau	Homo sapiens	91-94
27738646-13	2016	Liposomes bearing oxidized phosphatidylcholine without pCRP promoted a uniform M1 macrophage and Th1 pro-inflammatory response.	Phosphatidylcholines	27-46	negative elongation factor complex member C/D	Homo sapiens	97-100
27524956-7	2016	Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations.	Phosphatidylcholines	177-196	aldehyde dehydrogenase 1 family member B1	Homo sapiens	223-230
27524956-7	2016	Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations.	Phosphatidylcholines	177-196	membrane bound O-acyltransferase domain containing 1	Homo sapiens	232-238
27524956-7	2016	Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations.	Phosphatidylcholines	177-196	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	240-244
27524956-7	2016	Using workflow based exploitation of pathway databases and by integrating our metabolomics data with our gene expression data from the same patients we identified 4 deregulated phosphatidylcholine metabolism related genes (ALDH1B1, MBOAT1, MTRR and PLB1) that showed significant association with the changes in metabolite concentrations.	Phosphatidylcholines	177-196	phospholipase B1	Homo sapiens	249-253
27245897-1	2016	In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine.	Phosphatidylcholines	230-249	bromodomain containing 2	Homo sapiens	19-36
27245897-1	2016	In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine.	Phosphatidylcholines	230-249	bromodomain containing 2	Homo sapiens	38-41
26505974-8	2015	Replenishing luminal phosphatidylcholine and taurocholate (n = 9) only enhanced apoA-V secretion in bile, suggesting that the increase was not due to depletion of phospholipids or bile salts.	Phosphatidylcholines	21-40	apolipoprotein A5	Rattus norvegicus	80-86
30191692-2	2016	SGMS1 gene encodes an essential enzyme which is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide, wich determines its participation in the regulation of intracellular vesicular transport, cholesterol metabolism, cell proliferation, apoptosis and other significant processes.	Phosphatidylcholines	115-134	sphingomyelin synthase 1	Homo sapiens	0-5
26470810-2	2015	An exploration of intracellular signaling pathways revealed the TRH-induced current to be insensitive to phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitors, but reduced by D609, an inhibitor of phosphatidylcholine-specific PLC (PC-PLC).	Phosphatidylcholines	209-228	thyrotropin releasing hormone	Rattus norvegicus	64-67
26629827-12	2015	CONCLUSIONS: Metformin and phosphatidylcholine attenuated lipopolysaccharide induced toll-like receptor 4 overexpression and overproduction of pro-inflammatory cytokines; however, their efficacy depended on combined presence of non-alcoholic fatty liver disease, metabolic syndrome and obesity.	Phosphatidylcholines	27-46	toll like receptor 4	Homo sapiens	85-105
26665171-3	2015	We show that protein arginine methyltransferase 8 (PRMT8) acts as a phospholipase that directly hydrolyzes PC, generating choline and phosphatidic acid.	Phosphatidylcholines	107-109	protein arginine N-methyltransferase 8	Mus musculus	13-49
26665171-3	2015	We show that protein arginine methyltransferase 8 (PRMT8) acts as a phospholipase that directly hydrolyzes PC, generating choline and phosphatidic acid.	Phosphatidylcholines	107-109	protein arginine N-methyltransferase 8	Mus musculus	51-56
26665171-6	2015	Choline and acetylcholine levels were significantly decreased, whereas PC levels were increased, in the cerebellum of prmt8 (-/-) mice.	Phosphatidylcholines	71-73	protein arginine N-methyltransferase 8	Mus musculus	118-123
26417903-0	2015	Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels.	Phosphatidylcholines	126-145	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	0-38
26391255-2	2015	Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	142-161	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
26391255-2	2015	Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	142-161	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
26391255-2	2015	Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	163-165	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
26391255-2	2015	Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	163-165	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	81-101	phospholipase A2, group IB, pancreas	Mus musculus	110-126
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	81-101	lysophosphatidylcholine acyltransferase 1	Mus musculus	158-199
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	81-101	lysophosphatidylcholine acyltransferase 1	Mus musculus	201-207
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	38-40	phospholipase A2, group IB, pancreas	Mus musculus	110-126
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	38-40	lysophosphatidylcholine acyltransferase 1	Mus musculus	158-199
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	38-40	lysophosphatidylcholine acyltransferase 1	Mus musculus	201-207
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	103-105	phospholipase A2, group IB, pancreas	Mus musculus	110-126
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	103-105	lysophosphatidylcholine acyltransferase 1	Mus musculus	158-199
26708397-1	2015	BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1).	Phosphatidylcholines	103-105	lysophosphatidylcholine acyltransferase 1	Mus musculus	201-207
26417903-0	2015	Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels.	Phosphatidylcholines	126-145	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	Mus musculus	40-46
25926691-1	2015	Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms.	Phosphatidylcholines	220-239	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-51
26390854-8	2015	In addition, dietary restriction in aged worms resulting from sarcopenia of the pharyngeal pump likely decreases the abundance of SAMS-1, possibly leading to decreased phosphatidylcholine levels, larger lipid droplets, and ER and mitochondrial stress.	Phosphatidylcholines	168-187	putative S-adenosylmethionine synthase 1	Caenorhabditis elegans	130-136
25926691-1	2015	Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms.	Phosphatidylcholines	220-239	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
25790072-6	2015	The levels of plastid-synthesized lipids, mono- and di-galactosyldiacylglycerol and phosphatidylglycerol were reduced more in senescence-induced LEC2 than in endoplasmic reticulum-synthesized lipids, including phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol.	Phosphatidylcholines	210-229	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	145-149
26438561-5	2015	We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6).	Phosphatidylcholines	140-159	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-24
26438561-5	2015	We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6).	Phosphatidylcholines	161-163	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-24
26503172-2	2015	Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis.	Phosphatidylcholines	72-91	choline kinase alpha	Homo sapiens	0-14
26503172-2	2015	Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis.	Phosphatidylcholines	72-91	choline kinase alpha	Homo sapiens	16-19
26503172-2	2015	Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis.	Phosphatidylcholines	93-99	choline kinase alpha	Homo sapiens	0-14
26503172-2	2015	Choline kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis.	Phosphatidylcholines	93-99	choline kinase alpha	Homo sapiens	16-19
26552767-5	2015	RESULTS: From six female and six male cats PEMT activity was assayed directly in liver biopsies taken before and after spaying/neutering, and assessed indirectly by analyses of PEMT-specific hepatic phosphatidylcholine (PC) species and plasma choline levels.	Phosphatidylcholines	199-218	phosphatidylethanolamine N-methyltransferase	Felis catus	177-181
27022467-8	2015	DGAT1 inhibition leads to enhancement of carbon flow to the synthesis of phosphatidylcholine within the intestine.	Phosphatidylcholines	73-92	diacylglycerol O-acyltransferase 1	Mus musculus	0-5
26275961-7	2015	Furthermore, we demonstrate that clustered LD in fld1 or ldb16 mutants are transformed to SLD if phosphatidylcholine synthesis is compromised by additional deletion of the phosphatidylethanolamine methyltransferase, Cho2.	Phosphatidylcholines	97-116	seipin	Saccharomyces cerevisiae S288C	49-53
26438722-3	2015	Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3.	Phosphatidylcholines	135-154	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	185-189
26438722-3	2015	Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3.	Phosphatidylcholines	135-154	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	194-198
26275961-7	2015	Furthermore, we demonstrate that clustered LD in fld1 or ldb16 mutants are transformed to SLD if phosphatidylcholine synthesis is compromised by additional deletion of the phosphatidylethanolamine methyltransferase, Cho2.	Phosphatidylcholines	97-116	Ldb16p	Saccharomyces cerevisiae S288C	57-62
26226572-2	2015	The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function.	Phosphatidylcholines	162-165	lysophosphatidylcholine acyltransferase 3	Mus musculus	33-72
26226572-2	2015	The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function.	Phosphatidylcholines	162-165	lysophosphatidylcholine acyltransferase 3	Mus musculus	74-79
26226572-12	2015	Oral administration of PC and olive oil allowed the LPCAT3 KO mice to survive with the same body weights as controls, but the KO mice had shorter and wider small-intestinal villi and longer and bigger small intestines.	Phosphatidylcholines	23-25	lysophosphatidylcholine acyltransferase 3	Mus musculus	52-58
26277750-1	2015	Classical lipases are well known for being enzymes hydrolysing triacylglycerols as substrate, except the porcine pancreatic lipase (PPL) which was able to hydrolyze phosphatidylcholine.	Phosphatidylcholines	165-184	pancreatic triacylglycerol lipase	Meleagris gallopavo	113-130
26290611-7	2015	ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane.	Phosphatidylcholines	53-72	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-5
26474149-3	2015	Here, we observed that a high positive curvature of lipid vesicles with diameters of ~30 nm enhanced the association of Abeta with anionic phosphatidylglycerol membranes in the liquid-crystalline phase and with zwitterionic phosphatidylcholine membranes in the gel phase.	Phosphatidylcholines	224-243	amyloid beta precursor protein	Homo sapiens	120-125
26218418-6	2015	SUMMARY: A growing body of work demonstrates that nutrients present in high-fat foods (phosphatidylcholine, choline and L-carnitine) can be metabolized by the gut microbial enzymes to generate trimethylamine, which is then further metabolized by the host enzyme FMO3 to produce proatherogenic TMAO.	Phosphatidylcholines	87-106	flavin containing monooxygenase 3	Mus musculus	262-266
26290611-7	2015	ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane.	Phosphatidylcholines	53-72	acyl-CoA binding domain containing 6	Homo sapiens	10-15
26290611-7	2015	ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane.	Phosphatidylcholines	74-76	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-5
26290611-7	2015	ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane.	Phosphatidylcholines	74-76	acyl-CoA binding domain containing 6	Homo sapiens	10-15
26290611-8	2015	The acylation rate of lysophosphatidylcholine into PC catalyzed by the red cell lysophosphatidylcholine-acyltransferase 1 protein was limited by the transfer of the acyl-CoA substrate from ACBD6 to the acyltransferase enzyme.	Phosphatidylcholines	51-53	lysophosphatidylcholine acyltransferase 1	Homo sapiens	80-121
26290611-8	2015	The acylation rate of lysophosphatidylcholine into PC catalyzed by the red cell lysophosphatidylcholine-acyltransferase 1 protein was limited by the transfer of the acyl-CoA substrate from ACBD6 to the acyltransferase enzyme.	Phosphatidylcholines	51-53	acyl-CoA binding domain containing 6	Homo sapiens	189-194
26568975-3	2015	Topologies are provided for four phosphatidylcholines: saturated DPPC, mono-cis unsaturated POPC and DOPC, and mono-trans unsaturated PEPC.	Phosphatidylcholines	33-53	peptidase C	Homo sapiens	134-138
26260533-2	2015	Lysophosphatidylcholine acyltransferase (LPCAT) is a critical phospholipid biosynthesis enzyme, which promotes the conversion of lysophosphatidylcholine into phosphatidylcholine in the remodeling pathway of PC biosynthesis.	Phosphatidylcholines	4-23	lysophosphatidylcholine acyltransferase 1	Homo sapiens	41-46
26841664-8	2015	The higher is ratio cholesterol alcohol/phosphatidylcholines in mono-layer of lipoproteins of very low density the slower is lipolysis, formation of ligand lipoproteins of very low density and their absorption by cells under apoB-100-endocytosis.	Phosphatidylcholines	40-60	apolipoprotein B	Homo sapiens	225-233
26295742-7	2015	Phosphatidylcholine and phosphatidylethanolamine (PE) demonstrated the largest consumption of mass during thrombin stimulation.	Phosphatidylcholines	0-19	coagulation factor II, thrombin	Homo sapiens	106-114
26402860-1	2015	PURPOSE: The role of phosphatidylcholine-specific phospholipase C (PC-PLC), the enzyme involved in cell differentiation and proliferation, has not yet been explored in tumor initiating cells (TICs).	Phosphatidylcholines	21-40	heparan sulfate proteoglycan 2	Homo sapiens	70-73
26212548-11	2015	Gene expression analysis further showed decreased expression of PC biosynthetic genes choline kinase a and b, which further accelerated conversion of lysophosphatidylcholine to phosphatidylcholines through increasing the expression of lysophosphatidylcholine acyltransferase 3.	Phosphatidylcholines	177-197	lysophosphatidylcholine acyltransferase 3	Homo sapiens	235-276
26256905-1	2015	INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes.	Phosphatidylcholines	247-266	ATP binding cassette subfamily B member 4	Homo sapiens	144-174
26256905-1	2015	INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes.	Phosphatidylcholines	247-266	ATP binding cassette subfamily B member 4	Homo sapiens	176-180
26256905-1	2015	INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes.	Phosphatidylcholines	247-266	ATP binding cassette subfamily B member 4	Homo sapiens	181-186
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	129-148	phosphate cytidylyltransferase 1A, choline	Homo sapiens	77-85
26208694-5	2015	Our group and others have further demonstrated that circulating TMAO levels are elevated in patients with type 2 diabetes mellitus compared to healthy controls and gut microbiota-dependent phosphatidylcholine metabolism has been implicated in metabolic dysregulation and insulin resistance in animal models.	Phosphatidylcholines	189-208	insulin	Homo sapiens	271-278
26322888-12	2015	The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p&lt; 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity.	Phosphatidylcholines	4-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	128-170
26322888-12	2015	The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p&lt; 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity.	Phosphatidylcholines	4-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	172-176
26322888-12	2015	The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p&lt; 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity.	Phosphatidylcholines	25-27	phosphatidylethanolamine N-methyltransferase	Mus musculus	128-170
26108622-0	2015	Nuclear-localized CTP:phosphocholine cytidylyltransferase alpha regulates phosphatidylcholine synthesis required for lipid droplet biogenesis.	Phosphatidylcholines	74-93	phosphate cytidylyltransferase 1A, choline	Homo sapiens	18-63
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	129-148	cut like homeobox 1	Homo sapiens	161-164
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	129-148	phosphate cytidylyltransferase 1A, choline	Homo sapiens	30-75
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	150-152	phosphate cytidylyltransferase 1A, choline	Homo sapiens	30-75
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	150-152	phosphate cytidylyltransferase 1A, choline	Homo sapiens	77-85
26108622-1	2015	The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.	Phosphatidylcholines	150-152	cut like homeobox 1	Homo sapiens	161-164
26108622-2	2015	Based on results with insect CCT homologues, translocation of nuclear CCTalpha onto cytoplasmic lipid droplets (LDs) is proposed to stimulate the synthesis of PC that is required for LD biogenesis and triacylglycerol (TAG) storage.	Phosphatidylcholines	159-161	phosphate cytidylyltransferase 1A, choline	Homo sapiens	70-78
26108622-10	2015	We conclude that CCTalpha increases PC synthesis for LD biogenesis by translocation to the nuclear envelope and not cytoplasmic LDs.	Phosphatidylcholines	36-38	phosphate cytidylyltransferase 1A, choline	Homo sapiens	17-25
26241051-2	2015	Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation.	Phosphatidylcholines	231-233	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	82-87
26241051-2	2015	Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation.	Phosphatidylcholines	231-233	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	88-93
26241051-2	2015	Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation.	Phosphatidylcholines	231-233	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	98-103
25409201-4	2015	We demonstrate that oxidized phospholipids accumulate within alveolar macrophages (AMs) after bleomycin injury and that murine and human AMs treated with oxidized phosphatidylcholine (oxPc) become polarized along an M2 phenotype and display enhanced production of transforming growth factor-beta1.	Phosphatidylcholines	163-182	transforming growth factor beta 1	Homo sapiens	264-296
26056930-5	2015	The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains.	Phosphatidylcholines	102-121	phospholipase A2 group X	Homo sapiens	25-30
26056930-5	2015	The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains.	Phosphatidylcholines	123-125	phospholipase A2 group X	Homo sapiens	25-30
26265748-6	2015	Moreover, PLIN4 mRNA expression levels in muscle correlated with the expression of genes involved in de novo phospholipid biosynthesis, with muscular content of phosphatidylethanolamine and phosphatidylcholine, and with the content of subsarcolemmal lipid droplets.	Phosphatidylcholines	190-209	perilipin 4	Homo sapiens	10-15
26307845-3	2015	Studies have confirmed that surface-active phospholipids (SAPLs), predominantly phosphatidylcholines (PCs), are responsible for the lubricating properties of lubricin in joints.	Phosphatidylcholines	80-100	proteoglycan 4	Rattus norvegicus	158-166
26307845-3	2015	Studies have confirmed that surface-active phospholipids (SAPLs), predominantly phosphatidylcholines (PCs), are responsible for the lubricating properties of lubricin in joints.	Phosphatidylcholines	102-105	proteoglycan 4	Rattus norvegicus	158-166
25524654-6	2015	Relative increases in lysophosphatidylcholines and unsaturated phosphatidylcholines (PCs) were also observed in wire-injured ApoE-/- carotid arteries.	Phosphatidylcholines	85-88	apolipoprotein E	Mus musculus	125-129
26122953-7	2015	The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid.	Phosphatidylcholines	116-135	phosphatidylglycerophosphate synthase 1	Homo sapiens	22-61
26122953-7	2015	The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid.	Phosphatidylcholines	116-135	phosphatidylglycerophosphate synthase 1	Homo sapiens	63-67
26122953-7	2015	The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid.	Phosphatidylcholines	137-139	phosphatidylglycerophosphate synthase 1	Homo sapiens	22-61
26122953-7	2015	The overexpression of phosphatidylglycerophosphate synthase 1 (PGS1) increased the cellular contents of PG + CL and phosphatidylcholine (PC), and reduced that of phosphatidic acid.	Phosphatidylcholines	137-139	phosphatidylglycerophosphate synthase 1	Homo sapiens	63-67
26122953-8	2015	PGS1 overexpression also elevated the mitochondrial contents of CL and PC, but had no effect on the number of mitochondria per cell.	Phosphatidylcholines	71-73	phosphatidylglycerophosphate synthase 1	Homo sapiens	0-4
25767038-9	2015	In contrast, a phase separation was distinguished for both PC mixtures by ESR and XRD, indicative that PDPC and POPC mixtures differed in micron vs nano domain organization.	Phosphatidylcholines	59-61	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	103-107
25841322-3	2015	These experiments revealed a significant decrease in levels of docosahexaenoic acid (DHA)-containing phosphatidylcholines (PCs), such as PC (diacyl-16:0/22:6), PC (diacyl-18:0/22:6), and PC (diacyl-18:1/22:6) in the L5 anterior horns of terminal stage (22-week-old) SOD1(G93A) mice.	Phosphatidylcholines	123-126	superoxide dismutase 1, soluble	Mus musculus	266-270
26020241-3	2015	Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms.	Phosphatidylcholines	27-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
26020241-3	2015	Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms.	Phosphatidylcholines	27-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
26120503-1	2015	INTRODUCTION: Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol.	Phosphatidylcholines	63-82	endothelin receptor type A	Homo sapiens	167-170
26120503-1	2015	INTRODUCTION: Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol.	Phosphatidylcholines	63-82	diacylglycerol kinase eta	Homo sapiens	172-176
26120503-2	2015	This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms receiving supplementation of phosphatidylcholine, and a genetic study of a risk variant of DGKH gene was performed in an attempt to provide an explanation for the potential beneficial effect of phosphatidylcholine supplementation.	Phosphatidylcholines	117-136	diacylglycerol kinase eta	Homo sapiens	179-183
26120503-2	2015	This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms receiving supplementation of phosphatidylcholine, and a genetic study of a risk variant of DGKH gene was performed in an attempt to provide an explanation for the potential beneficial effect of phosphatidylcholine supplementation.	Phosphatidylcholines	282-301	diacylglycerol kinase eta	Homo sapiens	179-183
26120503-9	2015	CONCLUSIONS: This study illustrated that a 16-year-old boy with hypomania symptoms responded well to supplementation of phosphatidylcholine and the boy carries a risk genotype in DGKH gene for bipolar disorder, which provides a possible explanation for the boy"s beneficial effect at the genetic level.	Phosphatidylcholines	120-139	diacylglycerol kinase eta	Homo sapiens	179-183
25783052-2	2015	The aim of this study was to evaluate the hepatoprotective effects of PC against carbon tetrachloride (CCl4), which is a well-known hepatotoxicant that causes extensive oxidative liver damage, and to investigate the mechanisms involved in this protective effect.	Phosphatidylcholines	70-72	chemokine (C-C motif) ligand 4	Mus musculus	103-107
25783052-5	2015	Histopathological evaluation of the liver also revealed that PC effectively ameliorated CCl4-induced hepatic injury and fibrosis.	Phosphatidylcholines	61-63	chemokine (C-C motif) ligand 4	Mus musculus	88-92
25783052-6	2015	In addition, PC significantly counteracted the increase in glutathione levels and glutathione-S-transferase activity induced by CCl4.	Phosphatidylcholines	13-15	chemokine (C-C motif) ligand 4	Mus musculus	128-132
25783052-8	2015	These results suggest that PC exerts its protective effects against CCl4-induced hepatotoxicity via its activities as an anti-oxidant and free radical scavenger.	Phosphatidylcholines	27-29	chemokine (C-C motif) ligand 4	Mus musculus	68-72
25944098-1	2015	Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells.	Phosphatidylcholines	65-84	aminoalcoholphosphotransferase	Arabidopsis thaliana	0-30
25944098-1	2015	Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells.	Phosphatidylcholines	65-84	aminoalcoholphosphotransferase	Arabidopsis thaliana	32-36
25944098-10	2015	The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues.	Phosphatidylcholines	170-172	aminoalcoholphosphotransferase 1	Arabidopsis thaliana	19-24
25944098-1	2015	Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells.	Phosphatidylcholines	86-88	aminoalcoholphosphotransferase	Arabidopsis thaliana	0-30
25944098-10	2015	The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues.	Phosphatidylcholines	170-172	aminoalcoholphosphotransferase 1	Arabidopsis thaliana	133-138
25944098-1	2015	Aminoalcoholphosphotransferase (AAPT) catalyzes the synthesis of phosphatidylcholine (PC) and phosphotidylethanolamine (PE), which are the most prevalent membrane phospholipids in all eukaryotic cells.	Phosphatidylcholines	86-88	aminoalcoholphosphotransferase	Arabidopsis thaliana	32-36
25944098-10	2015	The data show that AAPT1 and AAPT2 are essential to plant vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more than AAPT2 to PC production in vegetative tissues.	Phosphatidylcholines	170-172	aminoalcoholphosphotransferase	Arabidopsis thaliana	161-166
25433161-1	2015	BACKGROUND &amp; AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine biosynthesis.	Phosphatidylcholines	155-174	phosphatidylethanolamine N-methyltransferase	Mus musculus	23-67
25433161-1	2015	BACKGROUND &amp; AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine biosynthesis.	Phosphatidylcholines	155-174	phosphatidylethanolamine N-methyltransferase	Mus musculus	69-73
25604091-0	2015	Remodeling of host phosphatidylcholine by Chlamydia acyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets.	Phosphatidylcholines	19-38	acyl-CoA binding domain containing 6	Homo sapiens	109-114
25667315-0	2015	A small phospholipase A2-alpha from castor catalyzes the removal of hydroxy fatty acids from phosphatidylcholine in transgenic Arabidopsis seeds.	Phosphatidylcholines	93-112	phospholipase A 2A	Arabidopsis thaliana	8-30
25670729-10	2015	These findings support the hypothesis that differences in the ability to take up blood phosphatidylcholine from low-density lipoproteins play an important role in early lactation metabolic stability of dairy cows and indicate APOBR to contain a causative variant.	Phosphatidylcholines	87-106	apolipoprotein B receptor	Bos taurus	226-231
25803864-1	2015	BACKGROUND: The relevance of lysophosphatidylcholine acyltransferase1 (LPCAT1), a cytosolic enzyme in the remodeling pathway of phosphatidylcholine metabolism, in oral squamous cell carcinoma (OSCC) is unknown.	Phosphatidylcholines	33-52	lysophosphatidylcholine acyltransferase 1	Homo sapiens	71-77
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	109-128	Lipin family protein	Arabidopsis thaliana	42-77
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	109-128	Lipin family protein	Arabidopsis thaliana	79-83
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	109-128	phosphatidic acid phosphohydrolase 2	Arabidopsis thaliana	89-93
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	130-132	Lipin family protein	Arabidopsis thaliana	42-77
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	130-132	Lipin family protein	Arabidopsis thaliana	79-83
25862304-2	2015	We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana.	Phosphatidylcholines	130-132	phosphatidic acid phosphohydrolase 2	Arabidopsis thaliana	89-93
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	20-22	Lipin family protein	Arabidopsis thaliana	26-30
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	20-22	phosphatidic acid phosphohydrolase 2	Arabidopsis thaliana	31-35
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	20-22	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	67-107
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	20-22	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	109-113
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	173-175	Lipin family protein	Arabidopsis thaliana	26-30
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	173-175	phosphatidic acid phosphohydrolase 2	Arabidopsis thaliana	31-35
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	173-175	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	67-107
25862304-4	2015	The accumulation of PC in pah1 pah2 is suppressed by disruption of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE1 (CCT1), which encodes a key enzyme in the nucleotide pathway for PC biosynthesis.	Phosphatidylcholines	173-175	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	109-113
25862304-8	2015	Our data establish that membrane homeostasis is regulated by lipid composition in Arabidopsis and reveal a mechanism through which the abundance of PA, mediated by PAH activity, modulates CCT activity to govern PC content.	Phosphatidylcholines	211-213	RNA polymerase II transcription mediator	Arabidopsis thaliana	188-191
25632961-4	2015	A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine.	Phosphatidylcholines	182-201	mechanistic target of rapamycin kinase	Homo sapiens	29-33
25632961-4	2015	A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine.	Phosphatidylcholines	182-201	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-151
25632961-4	2015	A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine.	Phosphatidylcholines	182-201	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
25497764-4	2015	To reveal the reason for this discrepancy, we have examined the effect of Abeta on the fluidity of phosphatidylcholine membranes using spectroscopic methods.	Phosphatidylcholines	99-118	amyloid beta precursor protein	Homo sapiens	74-79
25497764-5	2015	The fluorescence anisotropy of DPH is dramatically increased on addition of Abeta to DPH-containing phosphatidylcholine membranes.	Phosphatidylcholines	100-119	amyloid beta precursor protein	Homo sapiens	76-81
25497764-8	2015	The observed CD bands of DPH are induced by a chiral environment of Abeta but not by that of the lipids, because positive CD bands appear regardless of the d/l-chirality of phosphatidylcholine.	Phosphatidylcholines	173-192	amyloid beta precursor protein	Homo sapiens	68-73
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	82-101	phosphatidylethanolamine N-methyltransferase	Homo sapiens	113-117
25601960-0	2015	ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner.	Phosphatidylcholines	14-33	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
25601960-1	2015	ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile.	Phosphatidylcholines	91-110	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
25601960-1	2015	ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile.	Phosphatidylcholines	112-114	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
25601960-7	2015	ABCB4 must have evolved to exert its maximum activity in the SM-rich membrane environment of the canalicular membrane, where it transports PC as the physiological substrate.	Phosphatidylcholines	139-141	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	82-101	betaine--homocysteine S-methyltransferase	Homo sapiens	122-126
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	82-101	ATP binding cassette subfamily B member 4	Homo sapiens	164-168
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	133-152	solute carrier family 22 member 1	Homo sapiens	66-70
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	133-152	solute carrier family 44 member 1	Homo sapiens	75-79
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	133-152	phosphatidylethanolamine N-methyltransferase	Homo sapiens	113-117
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	133-152	betaine--homocysteine S-methyltransferase	Homo sapiens	122-126
24620780-8	2015	The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers.	Phosphatidylcholines	133-152	ATP binding cassette subfamily B member 4	Homo sapiens	164-168
25259654-2	2015	This study aims to investigate the regulatory effects of the activity of UGT isoforms by two important lipid components phosphatidylcholine (PC) and lysophosphatidylcholines (LPC) using in vitro incubation system.	Phosphatidylcholines	120-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	73-76
26065260-1	2015	Sphingomyelin synthase 1 (SMS1) is an enzyme of vital importance which is responsible for the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells.	Phosphatidylcholines	145-164	sphingomyelin synthase 1	Homo sapiens	0-24
26065260-1	2015	Sphingomyelin synthase 1 (SMS1) is an enzyme of vital importance which is responsible for the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells.	Phosphatidylcholines	145-164	sphingomyelin synthase 1	Homo sapiens	26-30
25259654-2	2015	This study aims to investigate the regulatory effects of the activity of UGT isoforms by two important lipid components phosphatidylcholine (PC) and lysophosphatidylcholines (LPC) using in vitro incubation system.	Phosphatidylcholines	141-143	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	73-76
25533467-5	2015	The ATPase activity of wild type MDR3 was stimulated 2-fold by liver PC or 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine lipids.	Phosphatidylcholines	69-71	ATP binding cassette subfamily B member 4	Homo sapiens	33-37
25140391-7	2015	PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-2	choline kinase alpha	Mus musculus	58-72
25650664-5	2015	Tumor cell death in vivo translating into liver tumor regression was associated with augmented phosphatidylcholine synthesis by the PEMT pathway, known as a liver-specific tumor suppressor, and restored mitochondrial function and TCA cycle flux.	Phosphatidylcholines	95-114	phosphatidylethanolamine N-methyltransferase	Homo sapiens	132-136
25500141-7	2015	Inhibition of ACSL4 also prevented the large increase in PUFA-TAGs in HSCs upon activation and to a lesser extent the increase of arachidonate-containing phosphatidylcholine species.	Phosphatidylcholines	154-173	acyl-CoA synthetase long chain family member 4	Homo sapiens	14-19
25140391-7	2015	PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-2	choline kinase alpha	Mus musculus	74-78
25140391-7	2015	PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-2	phosphatidylethanolamine N-methyltransferase	Mus musculus	122-171
25140391-7	2015	PC is mainly synthesized through the Kennedy pathway with Choline Kinase (ChoK) as a key regulatory enzyme or through the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-2	phosphatidylethanolamine N-methyltransferase	Mus musculus	173-177
25519895-7	2015	Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes.	Phosphatidylcholines	77-96	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	27-31
25519895-7	2015	Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes.	Phosphatidylcholines	77-96	Atg7p	Saccharomyces cerevisiae S288C	115-119
25519895-7	2015	Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes.	Phosphatidylcholines	98-100	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	27-31
25173835-7	2015	An immunohistochemical examination revealed significantly worse disease-free and overall survival rates in patients with MDR3-negative HCC, in which the intratumoral accumulation of some phosphatidylcholine species was observed under imaging mass spectrometry.	Phosphatidylcholines	187-206	ATP binding cassette subfamily B member 4	Homo sapiens	121-125
25519904-1	2015	Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined.	Phosphatidylcholines	81-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	21-53
25519904-1	2015	Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined.	Phosphatidylcholines	81-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-60
25519904-1	2015	Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined.	Phosphatidylcholines	102-104	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	21-53
25519904-1	2015	Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined.	Phosphatidylcholines	102-104	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-60
25579789-0	2015	Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1.	Phosphatidylcholines	63-82	ATP binding cassette subfamily A member 1	Homo sapiens	96-101
25451916-3	2015	Here, we identify choline kinase beta (CHKB), a kinase involved in the biosynthesis of phosphatidylcholine, as a novel regulator of bone homeostasis.	Phosphatidylcholines	87-106	choline kinase beta	Mus musculus	18-37
25451916-3	2015	Here, we identify choline kinase beta (CHKB), a kinase involved in the biosynthesis of phosphatidylcholine, as a novel regulator of bone homeostasis.	Phosphatidylcholines	87-106	choline kinase beta	Mus musculus	39-43
25406316-3	2015	Several studies have suggested that Abeta peptides also bind to phosphatidylcholine membranes, which lead to deformation of membranes and fibrillation of Abeta.	Phosphatidylcholines	64-83	amyloid beta precursor protein	Homo sapiens	36-41
25406316-3	2015	Several studies have suggested that Abeta peptides also bind to phosphatidylcholine membranes, which lead to deformation of membranes and fibrillation of Abeta.	Phosphatidylcholines	64-83	amyloid beta precursor protein	Homo sapiens	154-159
24796972-6	2015	Lipidomics analysis identified seven lipid markers including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins and ceramides that were significantly decreased in serum of HFD-fed CYP7A1-tg mice.	Phosphatidylcholines	65-85	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	192-198
25380220-0	2015	Modeling and optimization of phospholipase A1-catalyzed hydrolysis of phosphatidylcholine using response surface methodology for lysophosphatidylcholine production.	Phosphatidylcholines	70-89	lipase H	Homo sapiens	29-45
25380220-1	2015	Modeling the phospholipase A1 (PLA1 )-catalyzed partial hydrolysis of soy phosphatidylcholine (PC) in hexane for the production of lysophosphatidylcholine (LPC) and optimizing the reaction conditions using response surface methodology were described.	Phosphatidylcholines	95-97	lipase H	Homo sapiens	13-29
25380220-1	2015	Modeling the phospholipase A1 (PLA1 )-catalyzed partial hydrolysis of soy phosphatidylcholine (PC) in hexane for the production of lysophosphatidylcholine (LPC) and optimizing the reaction conditions using response surface methodology were described.	Phosphatidylcholines	95-97	lipase H	Homo sapiens	31-35
30154994-6	2015	Based on these results, we postulate that the rise of H2O2 concentrations to the submillimolar levels registered during initiation of the apoptotic program may represent one signaling event that triggers the gain in peroxidatic function of the Cyt-c molecules bound to the abundant PE and PC membrane components.	Phosphatidylcholines	289-291	cytochrome c, somatic	Homo sapiens	244-249
26125130-12	2015	Collectively, these data establish that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis and suggest that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.	Phosphatidylcholines	48-67	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	114-119
26125130-5	2015	In this study, we show that the wild-type mice display a rhythmic accumulation of hepatic phosphatidylcholine with a peak at ZT 22-0 while clock-deficient Bmal1(-/-) mice show elevated phosphatidylcholine levels in the liver associated with an atherogenic lipoprotein profile.	Phosphatidylcholines	185-204	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	155-160
26125130-6	2015	Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1).	Phosphatidylcholines	159-178	choline kinase alpha	Mus musculus	219-227
26125130-6	2015	Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1).	Phosphatidylcholines	159-178	choline kinase beta	Mus musculus	267-274
26125130-6	2015	Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1).	Phosphatidylcholines	159-178	phosphatidylethanolamine N-methyltransferase	Mus musculus	279-283
26125130-6	2015	Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1).	Phosphatidylcholines	159-178	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	299-307
30154994-3	2015	Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes.	Phosphatidylcholines	177-196	cytochrome c, somatic	Homo sapiens	41-46
30154994-3	2015	Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes.	Phosphatidylcholines	198-200	cytochrome c, somatic	Homo sapiens	41-46
26125130-12	2015	Collectively, these data establish that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis and suggest that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.	Phosphatidylcholines	48-67	choline kinase alpha	Mus musculus	133-141
26125130-6	2015	Profiling of the mRNA expression of enzymes from the Kennedy and phosphatidylethanolamine N-methyltransferase pathways which control the production of hepatic phosphatidylcholine revealed a robust circadian pattern for Chkalpha while other mRNA showed low amplitude (Chkbeta and Pemt) or no rhythm (Cctalpha and Chpt1).	Phosphatidylcholines	159-178	choline phosphotransferase 1	Mus musculus	312-317
24594635-1	2015	OBJECTIVE: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a potentially lethal autosomal recessive liver disease associated with mutations in ABCB4, the gene encoding the canalicular translocator of phosphatidylcholine MDR3.	Phosphatidylcholines	216-235	ATP binding cassette subfamily B member 4	Homo sapiens	159-164
25472447-1	2015	BACKGROUND: Choline kinase alpha (ChoKalpha) is a critical enzyme in the synthesis of phosphatidylcholine, a major structural component of eukaryotic cell membranes.	Phosphatidylcholines	86-105	choline kinase alpha	Homo sapiens	12-32
24594635-5	2015	ABCB4 missense mutations were phenotyped in vitro by assessing their effects on MDR3 expression, subcellular localisation, and phosphatidylcholine-translocating activity.	Phosphatidylcholines	127-146	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
24594635-9	2015	Phosphatidylcholine efflux assays indicated that T201M, P479L, S978P and E1118K mutations impaired MDR3 activity to variable degrees.	Phosphatidylcholines	0-19	ATP binding cassette subfamily B member 4	Homo sapiens	99-103
25523098-1	2014	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival.	Phosphatidylcholines	75-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-40
25281863-5	2015	Moreover, ASMase modulates alterations of the methionine cycle and phosphatidylcholine homeostasis, two crucial events involved in SH that regulate methylation reactions, antioxidant defence and membrane integrity.	Phosphatidylcholines	67-86	sphingomyelin phosphodiesterase 1	Homo sapiens	10-16
25742922-12	2015	Although it was suggested that cholesterol esterase accelerated esterification of cholesterol incorporated into intestinal cells and acted as a transporter at the surface of intestinal cells, our research revealed that the accelerated cholesterol absorption was caused by hydrolysis of phosphatidylcholine in bile salt micelles.	Phosphatidylcholines	286-305	carboxyl ester lipase	Rattus norvegicus	31-51
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylcholines	171-190	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	57-61
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylcholines	171-190	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	63-67
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylcholines	171-190	aminophospholipid-translocating P4-type ATPase DNF3	Saccharomyces cerevisiae S288C	69-73
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylcholines	171-190	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	75-79
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylcholines	171-190	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	85-89
25671705-4	2015	CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	224-243	tropomyosin 3	Homo sapiens	7-11
25671705-4	2015	CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	245-247	tropomyosin 3	Homo sapiens	7-11
26042209-0	2015	Phosphatidylcholine-Mediated Aqueous Diffusion of Cellular Cholesterol Down-Regulates the ABCA1 Transporter in Human Skin Fibroblasts.	Phosphatidylcholines	0-19	ATP binding cassette subfamily A member 1	Homo sapiens	90-95
26042209-14	2015	CONCLUSION: Thus, phosphatidylcholine facilitates removal of cellular cholesterol, thereby negating the cholesterol-dependent induction of ABCA1 message, protein and function.	Phosphatidylcholines	18-37	ATP binding cassette subfamily A member 1	Homo sapiens	139-144
26274505-1	2015	The human sphingomyelin synthase 1 gene (SGMS1) encodes an essential enzyme that is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide.	Phosphatidylcholines	151-170	sphingomyelin synthase 1	Homo sapiens	10-34
26274505-1	2015	The human sphingomyelin synthase 1 gene (SGMS1) encodes an essential enzyme that is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide.	Phosphatidylcholines	151-170	sphingomyelin synthase 1	Homo sapiens	41-46
25523098-1	2014	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival.	Phosphatidylcholines	75-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-45
25523098-1	2014	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival.	Phosphatidylcholines	96-98	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-40
25523098-1	2014	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival.	Phosphatidylcholines	96-98	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-45
25201589-6	2014	Three of six structural mutations influence cholesteryl ester and phosphatidylcholine binding by CETP.	Phosphatidylcholines	66-85	cholesteryl ester transfer protein	Homo sapiens	97-101
25281910-5	2014	Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4.	Phosphatidylcholines	48-67	apolipoprotein E	Homo sapiens	16-21
25281910-5	2014	Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4.	Phosphatidylcholines	48-67	apolipoprotein E	Homo sapiens	26-31
25490414-1	2014	Phospholipase A2 (PLA2) changes the phosphatidylcholine contained in low-density lipoprotein (LDL) to lysophosphatidylcholine (LPC), which has various proatherogenic properties.	Phosphatidylcholines	36-55	phospholipase A2 group IB	Homo sapiens	0-16
25223608-5	2014	Recombinant SPLUNC1 produced in HEK 293 cells harbored several molecular species of sphingomyelin and phosphatidylcholine as its ligands.	Phosphatidylcholines	102-121	BPI fold containing family A member 1	Homo sapiens	12-19
25490414-1	2014	Phospholipase A2 (PLA2) changes the phosphatidylcholine contained in low-density lipoprotein (LDL) to lysophosphatidylcholine (LPC), which has various proatherogenic properties.	Phosphatidylcholines	36-55	phospholipase A2 group IB	Homo sapiens	18-22
25339683-12	2014	Besides SM, ASM also cleaves liposomal phosphatidylcholine.	Phosphatidylcholines	39-58	sphingomyelin phosphodiesterase 1	Homo sapiens	12-15
25339683-13	2014	Anionic phospholipids derived from the plasma membrane (phosphatidylglycerol and phosphatidic acid) stimulate SM and phosphatidylcholine hydrolysis by ASM more effectively than BMP, which is generated during endocytosis.	Phosphatidylcholines	117-136	sphingomyelin phosphodiesterase 1	Homo sapiens	151-154
25339664-4	2014	Loss of ABCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholipids, including 1-palmitoyl-2-(5"-oxovaleroyl)-sn-glycero-3-phosphocholine, in the lungs.	Phosphatidylcholines	66-86	ATP binding cassette subfamily G member 1	Mus musculus	8-13
25544413-1	2014	ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features.	Phosphatidylcholines	48-67	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
25255925-6	2014	RESULTS: Reelin interacted with the liposomes containing phosphatidylserine (PS) or phosphatidylcholine.	Phosphatidylcholines	84-103	reelin	Mus musculus	9-15
25544413-1	2014	ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features.	Phosphatidylcholines	48-67	ATP binding cassette subfamily B member 4	Homo sapiens	14-18
25218477-5	2014	Silencing of IDH1 expression using siRNA in astrocytes isolated from E18.5 mouse cortices led to increased incorporation of [(3)H]-palmitate into the phosphatidylcholines (PCs) and decreased the incorporation of [(3)H]-palmitate into sphingomyelin and the phosphatidylethanolamines (PEs).	Phosphatidylcholines	150-170	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	13-17
25396754-8	2014	Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives.	Phosphatidylcholines	176-195	E2F transcription factor 2	Mus musculus	71-75
25396754-8	2014	Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives.	Phosphatidylcholines	176-195	E2F transcription factor 2	Mus musculus	125-129
25258318-0	2014	Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.	Phosphatidylcholines	133-152	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	8-12
25258318-2	2014	We now report that Ypk1 also impacts the turnover of the major phospholipid, phosphatidylcholine (PC).	Phosphatidylcholines	77-96	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	19-23
25258318-2	2014	We now report that Ypk1 also impacts the turnover of the major phospholipid, phosphatidylcholine (PC).	Phosphatidylcholines	98-100	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	19-23
25258318-4	2014	Deletion of PLB1, a gene encoding a B-type phospholipase that hydrolyzes PC, in a ypk1Delta mutant curtails the increased PC deacylation.	Phosphatidylcholines	73-75	lysophospholipase	Saccharomyces cerevisiae S288C	12-16
25258318-4	2014	Deletion of PLB1, a gene encoding a B-type phospholipase that hydrolyzes PC, in a ypk1Delta mutant curtails the increased PC deacylation.	Phosphatidylcholines	122-124	lysophospholipase	Saccharomyces cerevisiae S288C	12-16
25258318-8	2014	Because Plb1 lacks a consensus phosphorylation site for Ypk1, we probed other processes under the control of Ypk1 that might be linked to PC turnover.	Phosphatidylcholines	138-140	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	109-113
25319916-1	2014	OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1.	Phosphatidylcholines	15-34	phospholipase A2 group IB	Rattus norvegicus	97-113
25319916-1	2014	OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1.	Phosphatidylcholines	15-34	lysophosphatidylcholine acyltransferase 1	Rattus norvegicus	164-205
25319916-1	2014	OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1.	Phosphatidylcholines	74-93	phospholipase A2 group IB	Rattus norvegicus	97-113
25319916-1	2014	OBJECTIVE: Lysophosphatidylcholine is generated through the hydrolysis of phosphatidylcholine by phospholipase A2 and reversely converted to phosphatidylcholine by lysophosphatidylcholine acyltransferase 1.	Phosphatidylcholines	74-93	lysophosphatidylcholine acyltransferase 1	Rattus norvegicus	164-205
25091896-0	2014	Human carotid plaque phosphatidylcholine specifically interacts with paraoxonase 1, increases its activity, and enhances its uptake by macrophage at the expense of its binding to HDL.	Phosphatidylcholines	21-40	paraoxonase 1	Homo sapiens	69-82
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	150-169	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	22-27
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	150-169	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	32-37
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	150-169	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	38-43
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	171-173	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	22-27
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	171-173	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	32-37
25315773-2	2014	The yeast P4-ATPases, Drs2p and Dnf1p/Dnf2p, flip nitrobenzoxadiazole-labeled phosphatidylserine at the Golgi complex and nitrobenzoxadiazole-labeled phosphatidylcholine (PC) at the plasma membrane, respectively.	Phosphatidylcholines	171-173	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	38-43
25315773-5	2014	We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin.	Phosphatidylcholines	120-122	ATPase phospholipid transporting 11A	Homo sapiens	14-20
25315773-5	2014	We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin.	Phosphatidylcholines	120-122	ATPase phospholipid transporting 11C	Homo sapiens	25-31
25193995-3	2014	In the Hint1(-/-) mice, serum total and esterified cholesterol were reduced 2.5-fold, and lysophosphatidylcholines (LPCs) and lysophosphatidic acids were 10-fold elevated in serum, with a corresponding fall in phosphatidylcholines (PCs).	Phosphatidylcholines	94-114	histidine triad nucleotide binding protein 1	Mus musculus	7-12
25069533-1	2014	BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly.	Phosphatidylcholines	81-100	protein C receptor, endothelial	Mus musculus	12-42
25069533-1	2014	BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly.	Phosphatidylcholines	81-100	protein C receptor, endothelial	Mus musculus	44-48
25069533-1	2014	BACKGROUND: Endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PC) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly.	Phosphatidylcholines	45-47	protein C receptor, endothelial	Mus musculus	12-42
25069533-2	2014	PC can be replaced with other lipids, such as lysophosphatidylcholine or platelet-activating factor, by the action of group V secretory phospholipase A2 (sPLA2-V), an enzyme that is upregulated in a variety of inflammatory conditions.	Phosphatidylcholines	0-2	phospholipase A2, group V	Mus musculus	154-159
25218477-5	2014	Silencing of IDH1 expression using siRNA in astrocytes isolated from E18.5 mouse cortices led to increased incorporation of [(3)H]-palmitate into the phosphatidylcholines (PCs) and decreased the incorporation of [(3)H]-palmitate into sphingomyelin and the phosphatidylethanolamines (PEs).	Phosphatidylcholines	172-175	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	13-17
25197053-4	2014	We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-112
24963152-5	2014	Adult offspring (both Ts65Dn and 2N) of choline-supplemented (vs. choline-unsupplemented) dams exhibited 60% greater (P&lt;=0.007) activity of hepatic PEMT, which functions in de novo choline synthesis and produces phosphatidylcholine (PC) enriched in docosahexaenoic acid.	Phosphatidylcholines	215-234	phosphatidylethanolamine N-methyltransferase	Mus musculus	151-155
24963152-5	2014	Adult offspring (both Ts65Dn and 2N) of choline-supplemented (vs. choline-unsupplemented) dams exhibited 60% greater (P&lt;=0.007) activity of hepatic PEMT, which functions in de novo choline synthesis and produces phosphatidylcholine (PC) enriched in docosahexaenoic acid.	Phosphatidylcholines	236-238	phosphatidylethanolamine N-methyltransferase	Mus musculus	151-155
24992464-2	2014	PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.	Phosphatidylcholines	23-42	phosphatidylserine synthase 1	Homo sapiens	152-181
24992464-2	2014	PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.	Phosphatidylcholines	23-42	phosphatidylserine synthase 2	Homo sapiens	186-215
24810251-8	2014	Furthermore, UPF1 up-regulated the contents of phospholipid species identified as phosphatidylcholines and phosphatidylethanolamines in the CSC-exposed HBECs, indicating possible suppression of inflammatory processes along with an increase in spermidine as an endogenous cytoprotector.	Phosphatidylcholines	82-102	UPF1 RNA helicase and ATPase	Homo sapiens	13-17
24953525-1	2014	Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile.	Phosphatidylcholines	284-303	ATP binding cassette subfamily B member 4	Homo sapiens	0-69
24953525-1	2014	Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile.	Phosphatidylcholines	284-303	ATP binding cassette subfamily B member 4	Homo sapiens	71-76
24953525-1	2014	Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile.	Phosphatidylcholines	284-303	ATP binding cassette subfamily B member 4	Homo sapiens	91-113
24953525-1	2014	Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile.	Phosphatidylcholines	284-303	ATP binding cassette subfamily B member 4	Homo sapiens	115-119
25197053-4	2014	We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	114-117
24832487-4	2014	The expression of mitopmt suppressed the choline auxotrophy of a double deletion mutant of PEM1 and PEM2 (pem1Deltapem2Delta) and enabled it to synthesize PC in the absence of choline.	Phosphatidylcholines	155-157	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	91-95
25205869-4	2014	Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities.	Phosphatidylcholines	69-88	lipase C, hepatic type	Homo sapiens	24-26
25205869-4	2014	Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities.	Phosphatidylcholines	69-88	carboxyl ester lipase	Homo sapiens	31-33
25205869-4	2014	Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities.	Phosphatidylcholines	69-88	phospholipase A and acyltransferase 1	Homo sapiens	131-146
24832487-4	2014	The expression of mitopmt suppressed the choline auxotrophy of a double deletion mutant of PEM1 and PEM2 (pem1Deltapem2Delta) and enabled it to synthesize PC in the absence of choline.	Phosphatidylcholines	155-157	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	100-104
24832487-6	2014	The pem1Deltapem2Delta strain deleted for PSD1 encoding the mitochondrial phosphatidylserine decarboxylase was able to grow because of the expression of mitopmt in the presence of ethanolamine, implying that PE from other organelles, probably from the ER, was converted to PC by mitopmt.	Phosphatidylcholines	273-275	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	4-22
24832487-6	2014	The pem1Deltapem2Delta strain deleted for PSD1 encoding the mitochondrial phosphatidylserine decarboxylase was able to grow because of the expression of mitopmt in the presence of ethanolamine, implying that PE from other organelles, probably from the ER, was converted to PC by mitopmt.	Phosphatidylcholines	273-275	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	42-46
25157578-10	2014	The changes in pattern of phosphocholine and phosphatidylcholine in milk through lactation observed in the bovine suggests that it is possible to manufacture infant formula that more closely matches these metabolites profile in human milk.	Phosphatidylcholines	45-64	Weaning weight-maternal milk	Bos taurus	68-72
25103814-3	2014	We have analyzed SERCA crystal structures in the presence of four different phosphatidylcholine lipids of different lengths and double-bond compositions, and we find three different binding sites for lipid head groups, which are apparently independent of the acyl moiety of the lipids used.	Phosphatidylcholines	76-95	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	17-22
25170810-1	2014	This paper presents the synthesis of structured phosphatidylcholine (PC) enriched with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) by transesterification of DHA/EPA-rich ethyl esters with PC using immobilized phospholipsase A1 (PLA1) in solvent-free medium.	Phosphatidylcholines	48-67	POU class 2 homeobox 3	Homo sapiens	243-247
25170810-1	2014	This paper presents the synthesis of structured phosphatidylcholine (PC) enriched with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) by transesterification of DHA/EPA-rich ethyl esters with PC using immobilized phospholipsase A1 (PLA1) in solvent-free medium.	Phosphatidylcholines	69-71	POU class 2 homeobox 3	Homo sapiens	243-247
25170810-3	2014	Secondly, the immobilized PLA1 was used to catalyze transesterification of PC and DHA/EPA-rich ethyl esters.	Phosphatidylcholines	75-77	POU class 2 homeobox 3	Homo sapiens	26-30
24723470-1	2014	UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases.	Phosphatidylcholines	43-62	ATP binding cassette subfamily B member 4	Homo sapiens	16-21
25118676-11	2014	The anticoagulant potency of Nk-PLA2beta which is higher than that of Nk-PLA2alpha is corroborated by its superior catalytic activity, its higher capacity for binding to phosphatidylcholine, and its greater strength of thrombin inhibition.	Phosphatidylcholines	170-189	phospholipase A2 group IIA	Homo sapiens	32-40
24677714-1	2014	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	84-103	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-49
24677714-1	2014	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	84-103	phosphatidylethanolamine N-methyltransferase	Mus musculus	51-55
24677714-1	2014	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	105-107	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-49
24677714-1	2014	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) catalyzes the synthesis of phosphatidylcholine (PC) in the liver.	Phosphatidylcholines	105-107	phosphatidylethanolamine N-methyltransferase	Mus musculus	51-55
24677714-6	2014	Mitochondrial PC levels were lower and PE levels were higher in livers from Pemt(-/-) compared with Pemt(+/+) mice, resulting in a 33% reduction of the PC-to-PE ratio.	Phosphatidylcholines	14-16	phosphatidylethanolamine N-methyltransferase	Mus musculus	76-80
24677714-6	2014	Mitochondrial PC levels were lower and PE levels were higher in livers from Pemt(-/-) compared with Pemt(+/+) mice, resulting in a 33% reduction of the PC-to-PE ratio.	Phosphatidylcholines	152-154	phosphatidylethanolamine N-methyltransferase	Mus musculus	76-80
24677714-10	2014	We observed a strong correlation between mitochondrial PC-to-PE ratio and cellular ATP levels in hepatoma cells that expressed various amounts of PEMT.	Phosphatidylcholines	55-57	phosphatidylethanolamine N-methyltransferase	Mus musculus	146-150
24811005-3	2014	Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility.	Phosphatidylcholines	90-109	phospholipase D1	Homo sapiens	0-16
24811005-3	2014	Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility.	Phosphatidylcholines	90-109	phospholipase D1	Homo sapiens	18-22
24723470-1	2014	UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases.	Phosphatidylcholines	64-66	ATP binding cassette subfamily B member 4	Homo sapiens	16-21
24723470-10	2014	ABCB4-mediated PC secretion was also increased by pharmacological activation of protein kinases A or C and decreased by inhibition of these kinases.	Phosphatidylcholines	15-17	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
24723470-12	2014	CONCLUSION: We identified disease-associated variants of ABCB4 involved in the phosphorylation of its N-terminal domain and leading to decreased PC secretion.	Phosphatidylcholines	145-147	ATP binding cassette subfamily B member 4	Homo sapiens	57-62
24949573-9	2014	In summary, betaine and phosphatidylcholine could be regarded as sensitive biomarkers for the toxic responses of BFP.	Phosphatidylcholines	24-43	ring finger protein 112	Rattus norvegicus	113-116
24637075-7	2014	In chondrocytes from Chkb(-/-) mice, phosphatidylcholine was slightly lower than in WT mice whereas the amount of phosphocholine was decreased by approximately 75%.	Phosphatidylcholines	37-56	choline kinase beta	Mus musculus	21-25
24995811-4	2014	The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking.	Phosphatidylcholines	62-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
24995811-4	2014	The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking.	Phosphatidylcholines	83-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	Phosphatidylcholines	229-248	syntaxin 1A	Homo sapiens	56-60
24835967-4	2014	Small-MFG milk contained more total polar lipids; however, the relative proportion of individual polar lipids did not differ with MFG size, with the exception of phosphatidylcholine, which was greater in small-MFG milk.	Phosphatidylcholines	162-181	Weaning weight-maternal milk	Bos taurus	214-218
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	56-75	lysophosphatidylcholine acyltransferase 2	Mus musculus	221-227
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	56-75	patchy fur	Mus musculus	150-153
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	94-96	patchy fur	Mus musculus	44-47
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	94-96	lysophosphatidylcholine acyltransferase 2	Mus musculus	221-227
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	94-96	patchy fur	Mus musculus	150-153
24910243-4	2014	PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization.	Phosphatidylcholines	18-37	phospholipase A2, group V	Mus musculus	0-6
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	56-75	lysophosphatidylcholine acyltransferase 1	Mus musculus	93-100
24850807-3	2014	Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and phosphatidylcholine (PC) in the inflammatory cells.	Phosphatidylcholines	56-75	patchy fur	Mus musculus	44-47
24909405-5	2014	(15)N chemical shift solid-state NMR spectroscopy indicates that the hydrophobic domain of p24 as well as a designed sequence of 19 hydrophobic amino acid residues adopt transmembrane alignments in phosphatidylcholine membranes.	Phosphatidylcholines	198-217	transmembrane p24 trafficking protein 2	Homo sapiens	91-94
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	Phosphatidylcholines	229-248	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	139-142
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	Phosphatidylcholines	250-252	syntaxin 1A	Homo sapiens	56-60
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	Phosphatidylcholines	250-252	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	139-142
24802400-3	2014	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy.	Phosphatidylcholines	59-78	phospholipase D1	Homo sapiens	0-16
24802400-3	2014	Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy.	Phosphatidylcholines	59-78	phospholipase D1	Homo sapiens	18-22
24813107-1	2014	The phospholipases D (PLD1 and 2) are signaling enzymes that catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid, a lipid second messenger involved in cell proliferation, and choline, a precursor of acetylcholine (ACh).	Phosphatidylcholines	88-107	phospholipase D1	Mus musculus	22-32
24889630-6	2014	Both patients also had lipodystrophy, severe insulin resistance, and diabetes, providing evidence for an additional and essential role for PCYT1A-generated PC in the normal function of white adipose tissue and insulin action.	Phosphatidylcholines	139-141	insulin	Homo sapiens	210-217
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	methionine adenosyltransferase I, alpha	Mus musculus	180-186
24769283-10	2014	Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation.	Phosphatidylcholines	102-121	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	58-62
24769283-10	2014	Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation.	Phosphatidylcholines	102-121	choline kinase beta	Rattus norvegicus	74-78
24769283-10	2014	Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation.	Phosphatidylcholines	123-125	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	58-62
24769283-10	2014	Also, taurine added to CDD caused decreased expression of PEMT, CHKa, and CHKb, key genes involved in phosphatidylcholine (PC) synthesis and liver fat accumulation.	Phosphatidylcholines	123-125	choline kinase beta	Rattus norvegicus	74-78
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	123-142	methionine adenosyltransferase I, alpha	Mus musculus	180-186
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	123-142	phosphatidylethanolamine N-methyltransferase	Mus musculus	200-244
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	123-142	phosphatidylethanolamine N-methyltransferase	Mus musculus	246-250
24657456-0	2014	Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury.	Phosphatidylcholines	91-110	interleukin 6	Mus musculus	12-16
24843123-4	2014	In the present study, we find that worms with mutated or depleted mdt-15 (mdt-15 worms) exhibit decreased membrane phospholipid desaturation, especially in phosphatidylcholine.	Phosphatidylcholines	156-175	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	66-72
24843123-4	2014	In the present study, we find that worms with mutated or depleted mdt-15 (mdt-15 worms) exhibit decreased membrane phospholipid desaturation, especially in phosphatidylcholine.	Phosphatidylcholines	156-175	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	74-80
24583375-3	2014	Our results show that the CDP-choline pathway is the only de novo route for PC biosynthesis in both HOB and MG-63 cells.	Phosphatidylcholines	76-78	cut like homeobox 1	Homo sapiens	26-29
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	200-244
24184426-1	2014	Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	246-250
24556610-2	2014	It has been shown that the overexpression of ACYL-COENZYME A-BINDING PROTEIN6 (ACBP6) resulted in enhanced freezing tolerance in seedlings and rosettes accompanied by a decrease in phosphatidylcholine (PC), an increase in phosphatidic acid (PA) and an up-regulation of PHOSPHOLIPASE Ddelta(PLDdelta) in the absence of COLD-RESPONSIVE (COR)-related gene induction.	Phosphatidylcholines	202-204	acyl-CoA-binding protein 6	Arabidopsis thaliana	45-77
24717363-10	2014	Women with higher fasting concentrations of leucine and isoleucine and lower fasting concentrations of sphingomyelins and phosphatidylcholines had higher insulin responses despite similar glucose concentration after all kinds of bread (cross-validated ANOVA, P = 0.048).	Phosphatidylcholines	122-142	insulin	Homo sapiens	154-161
24556610-2	2014	It has been shown that the overexpression of ACYL-COENZYME A-BINDING PROTEIN6 (ACBP6) resulted in enhanced freezing tolerance in seedlings and rosettes accompanied by a decrease in phosphatidylcholine (PC), an increase in phosphatidic acid (PA) and an up-regulation of PHOSPHOLIPASE Ddelta(PLDdelta) in the absence of COLD-RESPONSIVE (COR)-related gene induction.	Phosphatidylcholines	202-204	acyl-CoA-binding protein 6	Arabidopsis thaliana	79-84
23845852-3	2014	In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide.	Phosphatidylcholines	304-323	ceramide transporter 1	Homo sapiens	157-161
24779728-0	2014	Formation of highly structured cubic micellar lipid nanoparticles of soy phosphatidylcholine and glycerol dioleate and their degradation by triacylglycerol lipase.	Phosphatidylcholines	73-92	lipase C, hepatic type	Homo sapiens	140-162
24480410-4	2014	Association of Hsp70 with phosphatidylcholine (PC) liposomes is weak, with insertion of its Trps into the bilayer hydrocarbon region.	Phosphatidylcholines	26-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
24480410-4	2014	Association of Hsp70 with phosphatidylcholine (PC) liposomes is weak, with insertion of its Trps into the bilayer hydrocarbon region.	Phosphatidylcholines	47-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
23845852-3	2014	In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide.	Phosphatidylcholines	325-331	ceramide transporter 1	Homo sapiens	157-161
24556997-4	2014	Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer.	Phosphatidylcholines	88-107	phospholipase D1	Homo sapiens	48-64
24556997-4	2014	Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer.	Phosphatidylcholines	88-107	phospholipase D1	Homo sapiens	66-70
24556997-4	2014	Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer.	Phosphatidylcholines	109-115	phospholipase D1	Homo sapiens	48-64
24556997-4	2014	Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer.	Phosphatidylcholines	109-115	phospholipase D1	Homo sapiens	66-70
24667182-1	2014	Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.	Phosphatidylcholines	114-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
24045840-1	2014	The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile".	Phosphatidylcholines	61-80	ATP binding cassette subfamily B member 4	Homo sapiens	4-9
24045840-1	2014	The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile".	Phosphatidylcholines	61-80	ATP binding cassette subfamily B member 4	Homo sapiens	27-31
24806754-1	2014	UNLABELLED: ABCB4 flops phosphatidylcholine into the bile canaliculus to protect the biliary tree from the detergent activity of bile salts.	Phosphatidylcholines	24-43	ATP binding cassette subfamily B member 4	Homo sapiens	12-17
24648496-3	2014	Mutants defective in MET regulon repression reveal that loss of Cho2, which is required for the methylation of phosphatidylethanolamine to produce phosphatidylcholine, leads to induction of the MET regulon.	Phosphatidylcholines	147-166	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	64-68
24560778-1	2014	CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis.	Phosphatidylcholines	43-62	cut-like homeobox 1	Rattus norvegicus	0-3
24763383-1	2014	The C2 domain of PKCalpha (C2alpha) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine.	Phosphatidylcholines	207-226	protein kinase C alpha	Homo sapiens	17-25
24368210-3	2014	Based on a kinetic comparative study between various pancreatic lipase family members, we showed here that porcine pancreatic lipase (PPL), which was so far classified as "classical lipase", was able to hydrolyze phosphatidylcholine (PC).	Phosphatidylcholines	213-232	pancreatic lipase	Homo sapiens	53-70
24368210-3	2014	Based on a kinetic comparative study between various pancreatic lipase family members, we showed here that porcine pancreatic lipase (PPL), which was so far classified as "classical lipase", was able to hydrolyze phosphatidylcholine (PC).	Phosphatidylcholines	213-232	pancreatic lipase	Homo sapiens	115-132
24368210-5	2014	Molecular dynamics was applied to investigate PC binding modes within the catalytic cavity of PPL and human pancreatic lipase (HPL), aiming to explain the difference of specificity of these enzymes towards phospholipids.	Phosphatidylcholines	46-48	pancreatic lipase	Homo sapiens	108-125
24368210-5	2014	Molecular dynamics was applied to investigate PC binding modes within the catalytic cavity of PPL and human pancreatic lipase (HPL), aiming to explain the difference of specificity of these enzymes towards phospholipids.	Phosphatidylcholines	46-48	galectin 1	Homo sapiens	127-130
25831888-4	2014	SMS1 enzyme, encoded by this gene, catalyzes the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide.	Phosphatidylcholines	100-119	sphingomyelin synthase 1	Homo sapiens	0-4
25097470-8	2014	RESULTS: THE FOLLOWING PROFILE OF APL IGG OR IGM WAS OBTAINED FROM PATIENTS WITH LOS: cardiolipin 15/45, phosphatidic acid 41/45, phosphatidyl-choline 0/45, -ethanolamine 6/45, -glycerole 1/45 (patient with Lyme disease), -inositol 7/45, -serine 14/45, annexin V 34/45, beta2GPI 21/45, prothrombin 30/45.	Phosphatidylcholines	130-150	coagulation factor II, thrombin	Homo sapiens	286-297
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	97-103	choline kinase alpha	Homo sapiens	137-141
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	97-103	choline kinase alpha	Homo sapiens	151-176
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1A, choline	Homo sapiens	193-199
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1A, choline	Homo sapiens	213-264
24667182-1	2014	Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.	Phosphatidylcholines	114-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
24667182-1	2014	Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.	Phosphatidylcholines	135-137	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
24667182-1	2014	Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.	Phosphatidylcholines	135-137	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
24667182-2	2014	Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	42-46
24333558-1	2014	The work introduces the quenching of silica coated Tb(III) complexes by merocyanine 540 (MC540) and copper ions as a tool to reveal the adsorption of phosphatidylcholine (PC) and phosphatidylserine (PS) at various PS:PC ratio onto silica nanoparticles doped with Tb(III) complex.	Phosphatidylcholines	150-169	surfactant protein C	Homo sapiens	214-219
24357062-6	2014	Treatment with apolipoprotein A-I or reconstituted HDLs consisting of apolipoprotein A-I complexed with phosphatidylcholine 24 hours before and at days 1, 7, 9, and 11 after PG-PS administration reduced acute and chronic joint inflammation.	Phosphatidylcholines	104-123	apolipoprotein A1	Rattus norvegicus	15-33
24357062-6	2014	Treatment with apolipoprotein A-I or reconstituted HDLs consisting of apolipoprotein A-I complexed with phosphatidylcholine 24 hours before and at days 1, 7, 9, and 11 after PG-PS administration reduced acute and chronic joint inflammation.	Phosphatidylcholines	104-123	apolipoprotein A1	Rattus norvegicus	70-88
24484915-11	2014	There was increased generation of oxidized phosphatidylcholine, a marker of OS, in NOS3(-/-) female mice receiving DOX+TRZ compared with control mice.	Phosphatidylcholines	43-62	nitric oxide synthase 3, endothelial cell	Mus musculus	83-87
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Phosphatidylcholines	36-55	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	142-146
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Phosphatidylcholines	36-55	galactokinase	Saccharomyces cerevisiae S288C	203-207
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Phosphatidylcholines	36-55	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	248-252
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Phosphatidylcholines	36-55	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	257-261
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Phosphatidylcholines	57-59	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	142-146
24333558-2	2014	The binding of MC540 with PC-based bilayers and copper ions with PS-based ones are the basis of their use as organic and inorganic probes to sense PS:PC ratio in silica supported mixed bilayers.	Phosphatidylcholines	26-28	surfactant protein C	Homo sapiens	147-152
24368431-2	2014	In mammals, choline is synthesized via phosphatidylethanolamine N-methyltransferase (Pemt), which converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	135-154	phosphatidylethanolamine N-methyltransferase	Mus musculus	85-89
24122873-0	2014	Peroxisome proliferator-activated receptor alpha activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.	Phosphatidylcholines	182-201	peroxisome proliferator activated receptor alpha	Homo sapiens	0-48
24122873-1	2014	UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion.	Phosphatidylcholines	139-158	ATP binding cassette subfamily B member 4	Homo sapiens	90-94
24122873-1	2014	UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion.	Phosphatidylcholines	139-158	ATP binding cassette subfamily B member 4	Homo sapiens	95-100
24122873-1	2014	UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion.	Phosphatidylcholines	160-162	ATP binding cassette subfamily B member 4	Homo sapiens	90-94
24122873-1	2014	UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion.	Phosphatidylcholines	160-162	ATP binding cassette subfamily B member 4	Homo sapiens	95-100
24122814-1	2014	CSL112 is apoA-I purified from human plasma and reconstituted with phosphatidylcholine (PC) to form high-density lipoprotein (HDL)-particles suitable for infusion.	Phosphatidylcholines	88-90	apolipoprotein A1	Homo sapiens	10-16
23894007-1	2014	BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology.	Phosphatidylcholines	16-35	phospholipase A2 group IB	Homo sapiens	98-114
23894007-1	2014	BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology.	Phosphatidylcholines	16-35	phospholipase A2 group IB	Homo sapiens	116-120
23894007-1	2014	BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology.	Phosphatidylcholines	38-40	phospholipase A2 group IB	Homo sapiens	98-114
23894007-1	2014	BACKGROUND: Lysophosphatidylcholine (LPC), a derivative of phosphatidylcholine (PC) hydrolyzed by phospholipase A2 (PLA2), is reported to be increased in bile of the patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis, both of which are major risk factors for biliary tract cancers with undefined etiology.	Phosphatidylcholines	38-40	phospholipase A2 group IB	Homo sapiens	116-120
23894007-7	2014	CONCLUSIONS: These data suggest that PLA2, which catalyzes the hydrolysis of PC to yield LPC and free fatty acid, is supposed to be an important etiological factor in BECs injury in pancreaticobiliary maljunction or intrahepatic cholelithiasis.	Phosphatidylcholines	77-79	phospholipase A2 group IB	Homo sapiens	37-41
24456402-0	2014	Monitoring phosphatidic acid formation in intact phosphatidylcholine bilayers upon phospholipase D catalysis.	Phosphatidylcholines	49-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	83-98
23612856-1	2014	BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes.	Phosphatidylcholines	205-224	solute carrier family 22 member 1	Homo sapiens	127-155
23612856-1	2014	BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes.	Phosphatidylcholines	205-224	solute carrier family 22 member 1	Homo sapiens	157-161
23612856-1	2014	BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes.	Phosphatidylcholines	205-224	solute carrier family 22 member 1	Homo sapiens	162-169
24664753-4	2014	The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of VLC-PUFA in the retinal phosphatidylcholine (PC) fraction compared to retinas from wild-type mice.	Phosphatidylcholines	111-130	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	37-43
24333423-7	2014	When the recombinant HAS2 proteins were reconstituted into liposomes composed of both saturated phosphatidylcholine and cholesterol, this provided a higher enzyme activity as compared with the liposomes formed by phosphatidylcholine alone.	Phosphatidylcholines	96-115	hyaluronan synthase 2	Homo sapiens	21-25
24333423-7	2014	When the recombinant HAS2 proteins were reconstituted into liposomes composed of both saturated phosphatidylcholine and cholesterol, this provided a higher enzyme activity as compared with the liposomes formed by phosphatidylcholine alone.	Phosphatidylcholines	213-232	hyaluronan synthase 2	Homo sapiens	21-25
24333423-8	2014	Cholesterol regulates HAS2 activity in a biphasic manner, depending on the molar ratio of phosphatidylcholine to cholesterol.	Phosphatidylcholines	90-109	hyaluronan synthase 2	Homo sapiens	22-26
24387990-0	2014	Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy.	Phosphatidylcholines	49-68	phosphate cytidylyltransferase 1A, choline	Homo sapiens	13-19
24578622-1	2014	BACKGROUND: CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator.	Phosphatidylcholines	69-88	cut-like homeobox 1	Rattus norvegicus	12-15
24176936-3	2014	The transcription factor Steroidogenic Factor-1 (SF-1) is an excellent model to address this question, as it forms dynamic complexes with several chemically distinct lipid species (phosphatidylinositols, phosphatidylcholines and sphingolipids).	Phosphatidylcholines	204-224	splicing factor 1	Homo sapiens	25-53
24404395-1	2014	PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty acids.	Phosphatidylcholines	157-176	phospholipase A2 group IB	Homo sapiens	105-121
24404395-1	2014	PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty acids.	Phosphatidylcholines	157-176	phospholipase A2 group IB	Homo sapiens	123-127
24404396-3	2014	Furthermore, pathological lung conditions are associated with upregulated phospholipase A2 (PLA2), the predominant enzyme producing LPC in tissues by hydrolysis of phosphatidylcholine.	Phosphatidylcholines	164-183	phospholipase A2 group IB	Homo sapiens	74-90
24404396-3	2014	Furthermore, pathological lung conditions are associated with upregulated phospholipase A2 (PLA2), the predominant enzyme producing LPC in tissues by hydrolysis of phosphatidylcholine.	Phosphatidylcholines	164-183	phospholipase A2 group IB	Homo sapiens	92-96
23988655-3	2014	In addition, LC/MS lipidomics analysis of the CMOI-/- embryos showed reduced levels of four phosphatidylcholine and three phosphatidylethanolamine acyl chain species, and of eight triacylglycerol species with four or more unsaturations and fifty-two or more carbons in the acyl chains.	Phosphatidylcholines	92-111	beta-carotene oxygenase 1	Mus musculus	46-50
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	84-103	interleukin 1 beta	Mus musculus	0-8
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	84-103	interleukin 1 beta	Mus musculus	215-223
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	147-166	interleukin 1 beta	Mus musculus	0-8
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	147-166	interleukin 1 beta	Mus musculus	215-223
25133187-6	2014	In the presence of bile salts, ABCB4 located in nonraft membranes mediates the efflux of phospholipids, preferentially phosphatidylcholine.	Phosphatidylcholines	119-138	ATP binding cassette subfamily B member 4	Homo sapiens	31-36
24095834-6	2014	Electrospray ionization mass spectrometry of cellular phospholipids bearing AA showed that the levels of some, if not all, phosphatidylcholine (PC) and phosphatidylinositol species in Acsl4 knockdown cells were decreased after IL-1beta stimulation, while those in control cells were not so obviously decreased.	Phosphatidylcholines	123-142	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	184-189
24292666-0	2014	Protective effect of phosphatidylcholine on restoration of ethanol-injured hepatocytes related with caveolin-1.	Phosphatidylcholines	21-40	caveolin 1	Homo sapiens	100-110
25036123-1	2014	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA).	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
25036123-1	2014	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA).	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
25036123-1	2014	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA).	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
25036123-1	2014	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA).	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
24292666-9	2014	However, the levels of Caveolin-1 and PKC-alpha were increased by phosphatidylcholine administration.	Phosphatidylcholines	66-85	protein kinase C alpha	Homo sapiens	38-47
24772432-5	2014	Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation.	Phosphatidylcholines	13-15	mitogen-activated protein kinase kinase 7	Homo sapiens	68-71
24772432-5	2014	Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation.	Phosphatidylcholines	13-15	mitogen-activated protein kinase 3	Homo sapiens	72-78
24292666-10	2014	The results indicated that the inhibition of lipid peroxidation by phosphatidylcholine could lead to the prevention of membrane disruption, which closely correlated with the level of Caveolin-1.	Phosphatidylcholines	67-86	caveolin 1	Homo sapiens	183-193
24292666-9	2014	However, the levels of Caveolin-1 and PKC-alpha were increased by phosphatidylcholine administration.	Phosphatidylcholines	66-85	caveolin 1	Homo sapiens	23-33
24292666-11	2014	Since the protective effects of phosphatidylcholine against ethanol-induced lipid peroxidation might be regulated by phospholipid-PKC-alpha signaling pathway, related with Caveolin-1, the potential effects of phosphatidylcholine on membranes need to be verified.	Phosphatidylcholines	32-51	protein kinase C alpha	Homo sapiens	130-139
24204024-8	2014	Unexpectedly, in planta, E. coli CPS acts primarily on the sn-1 position of PC; coexpression of SfLPAT results in the incorporation of CPA at the sn-2 position of lysophosphatidic acid.	Phosphatidylcholines	76-78	Terpenoid cyclases/Protein prenyltransferases superfamily protein	Arabidopsis thaliana	33-36
24292666-11	2014	Since the protective effects of phosphatidylcholine against ethanol-induced lipid peroxidation might be regulated by phospholipid-PKC-alpha signaling pathway, related with Caveolin-1, the potential effects of phosphatidylcholine on membranes need to be verified.	Phosphatidylcholines	32-51	caveolin 1	Homo sapiens	172-182
24251714-7	2013	Lysophosphatidylcholine (lysoPC), a derivative of phosphatidylcholine hydrolysis by phospholipase A2, is a highly abundant bioactive lipid mediator present in circulation as well as in bile.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	84-100
24187140-0	2013	Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.	Phosphatidylcholines	37-56	Hnm1p	Saccharomyces cerevisiae S288C	95-99
24279474-8	2013	Purified and re-folded active rPlp exhibited phospholipase A2 activity against phosphatidylcholine and no activity against phosphatidylserine, phosphatidylethanolamine, or sphingomyelin.	Phosphatidylcholines	79-98	proteolipid protein 1	Rattus norvegicus	30-34
24287694-4	2013	Choline kinase alpha (ChoKalpha), the first enzyme in the Kennedy pathway, is responsible for the generation of phosphorylcholine (PCho) that ultimately renders phosphatidylcholine.	Phosphatidylcholines	161-180	choline kinase alpha	Homo sapiens	0-32
24062078-1	2013	Sphingomyelin synthase 1 (SMS1) is an essential enzyme that catalyses the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells.	Phosphatidylcholines	125-144	sphingomyelin synthase 1	Homo sapiens	0-24
24062078-1	2013	Sphingomyelin synthase 1 (SMS1) is an essential enzyme that catalyses the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide in eukaryotic cells.	Phosphatidylcholines	125-144	sphingomyelin synthase 1	Homo sapiens	26-30
24097981-6	2013	ABCA1 actively exported or flipped phosphatidylcholine, phosphatidylserine, and sphingomyelin from the cytoplasmic to the exocytoplasmic leaflet of membranes, whereas ABCA7 preferentially exported phosphatidylserine.	Phosphatidylcholines	35-54	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
24279474-0	2013	Characterization of Plp, a phosphatidylcholine-specific phospholipase and hemolysin of Vibrio anguillarum.	Phosphatidylcholines	27-46	proteolipid protein 1	Rattus norvegicus	20-23
24279474-11	2013	Additionally, rPlp had strong hemolytic activity towards rainbow trout erythrocytes, but not to sheep erythrocytes suggesting that rPlp is optimized for lysis of phosphatidylcholine-rich fish erythrocytes.	Phosphatidylcholines	162-181	proteolipid protein 1	Rattus norvegicus	14-18
24279474-11	2013	Additionally, rPlp had strong hemolytic activity towards rainbow trout erythrocytes, but not to sheep erythrocytes suggesting that rPlp is optimized for lysis of phosphatidylcholine-rich fish erythrocytes.	Phosphatidylcholines	162-181	proteolipid protein 1	Rattus norvegicus	131-135
24279474-14	2013	CONCLUSION: The plp gene of V. anguillarum encoding a phospholipase with A2 activity is specific for phosphatidylcholine and, therefore, able to lyse fish erythrocytes, but not sheep erythrocytes.	Phosphatidylcholines	101-120	proteolipid protein 1	Rattus norvegicus	16-19
24205231-6	2013	Under fasting conditions, carriers of TCF7L2 rs7903146 exhibited a non-significant increase of plasma sphingomyelins (SMs), phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) species.	Phosphatidylcholines	124-144	transcription factor 7 like 2	Homo sapiens	38-44
23963955-1	2013	Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine.	Phosphatidylcholines	194-213	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-22
23963955-1	2013	Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine.	Phosphatidylcholines	194-213	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	11-15
23963955-1	2013	Cytochrome P450 (P450) function requires the interaction of P450 and NADPH-cytochrome P450 reductase (CPR) in membranes, and is frequently studied using reconstituted systems composed solely of phosphatidylcholine.	Phosphatidylcholines	194-213	cytochrome p450 oxidoreductase	Homo sapiens	102-105
24153306-8	2013	Unbiased metabolite profiling identifies phosphatidylcholine 18:0/18:1 (PC(18:0/18:1) as a serum lipid regulated by diurnal hepatic PPARdelta activity.	Phosphatidylcholines	41-60	peroxisome proliferator activator receptor delta	Mus musculus	132-141
24080101-2	2013	Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes.	Phosphatidylcholines	86-105	cut like homeobox 1	Homo sapiens	49-52
24080101-2	2013	Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes.	Phosphatidylcholines	107-109	cut like homeobox 1	Homo sapiens	49-52
24025327-2	2013	This was accomplished by studying the exposure of PMCA to surrounding phospholipids by measuring the incorporation of the photoactivatable phosphatidylcholine analog 1-O-hexadecanoyl-2-O-[9-[[[2-[(125)I]iodo-4-(trifluoromethyl-3H-diazirin-3-yl)benzyl]oxy]carbonyl]nonanoyl]-sn-glycero-3-phosphocholine to the protein.	Phosphatidylcholines	139-158	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	50-54
24205231-6	2013	Under fasting conditions, carriers of TCF7L2 rs7903146 exhibited a non-significant increase of plasma sphingomyelins (SMs), phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) species.	Phosphatidylcholines	146-149	transcription factor 7 like 2	Homo sapiens	38-44
23945283-7	2013	SUMMARY: CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane.	Phosphatidylcholines	107-126	choline kinase beta	Homo sapiens	9-13
23917775-2	2013	Here, we show that a systemic treatment of mice bearing skin tumors with empty phosphatidylcholine liposomes (PCL) resulted in inhibition of tumor growth, which was similar to that observed with the synthetic bacterial lipoprotein and TLR1/2 agonist Pam(3)CSK(4) (BLP).	Phosphatidylcholines	79-98	gastrin releasing peptide	Mus musculus	264-267
23945283-7	2013	SUMMARY: CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane.	Phosphatidylcholines	107-126	choline kinase beta	Homo sapiens	22-41
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	75-94	phosphatidylethanolamine N-methyltransferase	Mus musculus	124-173
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	75-94	phosphatidylethanolamine N-methyltransferase	Mus musculus	175-179
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	75-94	glycine N-methyltransferase	Mus musculus	206-210
23872453-12	2013	The phthalocyanine-nitroimidazole conjugate, Pc-4 was encapsulated in phosphatidylglycerol:phosphatidylcholine unilamellar liposomes and subjected to photocytotoxicity study.	Phosphatidylcholines	91-110	SUB1 regulator of transcription	Homo sapiens	45-49
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	96-98	phosphatidylethanolamine N-methyltransferase	Mus musculus	124-173
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	96-98	phosphatidylethanolamine N-methyltransferase	Mus musculus	175-179
23505042-4	2013	We hypothesized that as an adaptive response to hepatic SAMe accumulation, phosphatidylcholine (PC) synthesis by way of the phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is stimulated in Gnmt(-/-) mice.	Phosphatidylcholines	96-98	glycine N-methyltransferase	Mus musculus	206-210
23505042-7	2013	We also observed that the flux from PE to PC is stimulated in the liver of Gnmt(-/-) mice and that this results in a reduction in PE content and a marked increase in DG and TG.	Phosphatidylcholines	42-44	glycine N-methyltransferase	Mus musculus	75-79
23505042-9	2013	Gnmt(-/-) mice with an additional deletion of perilipin2, the predominant lipid droplet protein, maintain high SAMe levels, with a concurrent increased flux from PE to PC, but do not develop liver steatosis.	Phosphatidylcholines	168-170	glycine N-methyltransferase	Mus musculus	0-4
23712050-8	2013	However, lipidomic analysis of the regenerating liver from Ldlr(-)(/)(-) revealed a lipid profile compatible with liver quiescence: high content of cholesterol esters and ceramide, and low levels of phosphatidylcholine.	Phosphatidylcholines	199-218	low density lipoprotein receptor	Mus musculus	59-63
23796515-3	2013	The dissociation constant of moesin FERM domain to CLS in the phosphatidylcholine liposome is about 300nM.	Phosphatidylcholines	62-81	moesin	Homo sapiens	29-35
23872271-11	2013	COX activity was lower in pect1-4 mitochondria at 5 weeks, most probably due to reduced phosphatidylethanolamine levels and/or an altered phosphatidylethanolamine:phosphatidylcholine ratio.	Phosphatidylcholines	163-182	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	26-31
23897804-5	2013	Vitellogenin binds directly to phosphatidylcholine liposomes and with higher affinity to liposomes containing phosphatidylserine, a lipid of the inner leaflet of cell membranes that is exposed in damaged cells.	Phosphatidylcholines	31-50	vitellogenin	Apis mellifera	0-12
23881110-4	2013	RESULTS: As compared with WT mice, unchallenged Abca3(+/-) mice had significantly decreased lung phosphatidylcholine (PC) and phosphatidylglycerol (PG) levels (P &lt; 0.02) and decreased lung compliance (P &lt; 0.05).	Phosphatidylcholines	97-116	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	48-53
23881110-4	2013	RESULTS: As compared with WT mice, unchallenged Abca3(+/-) mice had significantly decreased lung phosphatidylcholine (PC) and phosphatidylglycerol (PG) levels (P &lt; 0.02) and decreased lung compliance (P &lt; 0.05).	Phosphatidylcholines	118-120	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	48-53
23881110-7	2013	The ratio of PC to PG in BAL-relevant for surfactant dysfunction-was significantly elevated by oxygen exposure, with the greatest increase in Abca3(+/-) mice.	Phosphatidylcholines	13-15	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	142-147
23796515-4	2013	In contrast to disrupting the CaM association with CLS, inclusion of anionic phosphatidylserine lipids in the phosphatidylcholine liposome increased the apparent binding affinity of moesin FERM domain for CLS.	Phosphatidylcholines	110-129	moesin	Homo sapiens	182-188
24052074-0	2013	Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E-/-mice.	Phosphatidylcholines	68-87	annexin A7	Mus musculus	10-20
24052074-1	2013	Phosphatidylcholine-specific phospholipase C (PC-PLC) is a key factor in apoptosis and autophagy of vascular endothelial cells (VECs), and involved in atherosclerosis in apolipoprotein E-/- (apoE-/-) mice.	Phosphatidylcholines	0-19	apolipoprotein E	Mus musculus	170-199
23639419-2	2013	Many reports exist on PLD-mediated synthesis of natural and tailor-made PLs with functional head groups, from easily available lecithin or phosphatidylcholine.	Phosphatidylcholines	139-158	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	22-25
23816424-9	2013	FASN inhibitor treated Y79 RB and fibroblast cells showed decrease in the cellular lipids (triglyceride, cholesterol and phosphatidyl choline) levels.	Phosphatidylcholines	121-141	fatty acid synthase	Homo sapiens	0-4
23763823-3	2013	We found increased phosphatidylcholine and decreased ceramides in the brain of PGC1a-deficient mice.	Phosphatidylcholines	19-38	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	79-84
23850486-2	2013	Here, we showed that liposomes consisting of phosphatidylserine and lysophosphatidylcholine, a lipolysis product of phosphatidylcholine by PLA2, were phagocytosed by microglia, but failed to induce secretion of PGE2.	Phosphatidylcholines	72-91	phospholipase A2 group IB	Homo sapiens	139-143
23850486-5	2013	We thus hypothesize that free arachidonic acid is supplied through aiPLA2-mediated lipolysis of phagocytosed phosphatidylcholine, leading to the production of PGH2 and its downstream metabolites.	Phosphatidylcholines	109-128	peroxiredoxin 6	Homo sapiens	67-73
23801329-11	2013	Phosphatidylcholine vesicles containing LacCer increased cPLA2alpha activity.	Phosphatidylcholines	0-19	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	57-67
23135760-7	2013	ITF prebiotics also decreased Bacteroides intestinalis, Bacteroides vulgatus and Propionibacterium, an effect associated with a slight decrease in fat mass and with plasma lactate and phosphatidylcholine levels.	Phosphatidylcholines	184-203	trefoil factor 3	Homo sapiens	0-3
23931318-3	2013	Here, we determined the high-resolution structure of huntingtin 1-17 in dodecyl phosphocholine micelles and the topology of its helical domain in oriented phosphatidylcholine bilayers.	Phosphatidylcholines	155-174	huntingtin	Homo sapiens	53-63
23763831-7	2013	Mt-I rapidly hydrolyzed phosphatidylcholine and phosphatidylethanolamine but not phosphatidylserine, but no phospho-lipids were hydrolyzed in the presence of Mt-II.	Phosphatidylcholines	24-43	metallothionein 1	Mus musculus	0-4
23700249-0	2013	Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes.	Phosphatidylcholines	36-55	lysophospholipid acyltransferase 1	Ricinus communis	130-178
23794138-6	2013	Using electrospray ionization-mass spectrometry, we identified the species of triacylglycerols and phosphatidylcholines that were hydrolyzed by LPL and EL, and we identified the fatty acids liberated by gas chromatography-mass spectrometry.	Phosphatidylcholines	99-119	lipoprotein lipase	Homo sapiens	144-147
23794138-6	2013	Using electrospray ionization-mass spectrometry, we identified the species of triacylglycerols and phosphatidylcholines that were hydrolyzed by LPL and EL, and we identified the fatty acids liberated by gas chromatography-mass spectrometry.	Phosphatidylcholines	99-119	lipase G, endothelial type	Homo sapiens	152-154
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	phosphatidylcholine transfer protein	Mus musculus	47-52
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	phosphatidylcholine transfer protein	Mus musculus	79-84
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	acyl-CoA thioesterase 13	Mus musculus	90-95
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	TSC complex subunit 2	Mus musculus	100-104
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	phosphatidylcholine transfer protein	Mus musculus	79-84
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	acyl-CoA thioesterase 13	Mus musculus	134-139
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	insulin receptor substrate 2	Mus musculus	197-201
23901139-7	2013	Preventing phosphatidylcholine from binding to PC-TP disrupted interactions of PC-TP with THEM2 and TSC2, and disruption of the PC-TP-THEM2 complex was associated with increased activation of both IRS2 and mTORC1.	Phosphatidylcholines	11-30	CREB regulated transcription coactivator 1	Mus musculus	206-212
23811944-6	2013	The appearance of malignant changes correlated with a pronounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with activation of Akt and mTOR signaling that were attenuated by treatment with the mTOR inhibitor everolimus.	Phosphatidylcholines	77-96	thymoma viral proto-oncogene 1	Mus musculus	171-174
23811944-6	2013	The appearance of malignant changes correlated with a pronounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with activation of Akt and mTOR signaling that were attenuated by treatment with the mTOR inhibitor everolimus.	Phosphatidylcholines	77-96	mechanistic target of rapamycin kinase	Mus musculus	237-241
23727005-0	2013	Synthesis of mixed-chain phosphatidylcholines including coumarin fluorophores for FRET-based kinetic studies of phospholipase A(2) enzymes.	Phosphatidylcholines	25-45	phospholipase A2 group IB	Homo sapiens	112-130
23727005-4	2013	Here we report a new synthesis of double-labeled phosphatidylcholine analogs with chain-terminal reporter groups including coumarin fluorophores for fluorescence resonance energy transfer (FRET)-based kinetic studies of PLA2 enzymes.	Phosphatidylcholines	49-68	phospholipase A2 group IB	Homo sapiens	220-224
23727005-8	2013	Specifically, the rate of PLA2 hydrolysis of the coumarin labeled phosphatidylcholine analogs was less than three times slower than the natural substrate dipalmitoyl phosphatidylcholine (DPPC) under the same experimental conditions.	Phosphatidylcholines	66-85	phospholipase A2 group IB	Homo sapiens	26-30
23641021-5	2013	PC is mainly synthesized through the Kennedy pathway with choline kinase (ChoK) and CTP:phosphocholine cytidylyltranferase (CCT) as key regulatory enzymes.	Phosphatidylcholines	0-2	choline kinase alpha	Mus musculus	58-72
23641021-5	2013	PC is mainly synthesized through the Kennedy pathway with choline kinase (ChoK) and CTP:phosphocholine cytidylyltranferase (CCT) as key regulatory enzymes.	Phosphatidylcholines	0-2	choline kinase alpha	Mus musculus	74-78
23604781-2	2013	A model for delivering dietary sn-2-DHA phosphatidylcholine (PtdCho) to the brain involves phospholipase A2 based deacylation/reacylation cycle followed by delivery of DHA through high-density lipoproteins that bind to the brain capillary endothelial cells in the blood-brain barrier (BBB).	Phosphatidylcholines	61-67	phospholipase A2 group IB	Homo sapiens	91-107
23604781-6	2013	The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB.	Phosphatidylcholines	214-220	phospholipase A2 group IB	Homo sapiens	57-61
23604781-6	2013	The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB.	Phosphatidylcholines	214-220	phospholipase A2 group IIA	Homo sapiens	63-68
23604781-6	2013	The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB.	Phosphatidylcholines	214-220	lipase G, endothelial type	Homo sapiens	181-183
23564075-1	2013	The present study investigated the effects of DeltaPsi and DeltapH (pH gradient) on the interaction of cytochrome c with a mitochondrial mimetic membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) leading to vesicle fusion.	Phosphatidylcholines	166-185	cytochrome c, somatic	Homo sapiens	103-115
23564075-1	2013	The present study investigated the effects of DeltaPsi and DeltapH (pH gradient) on the interaction of cytochrome c with a mitochondrial mimetic membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) leading to vesicle fusion.	Phosphatidylcholines	187-189	cytochrome c, somatic	Homo sapiens	103-115
23723068-3	2013	PLD catalyzes the hydrolysis of phosphatidylcholine into PA.	Phosphatidylcholines	32-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
23228325-1	2013	BACKGROUND: Cytidine 5"-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine.	Phosphatidylcholines	108-127	cut-like homeobox 1	Rattus norvegicus	42-45
23228325-10	2013	In addition, NEC damage reduced intestinal tissue membrane phospholipids, whereas CDP-choline significantly enhanced total phospholipid and phosphatidylcholine levels.	Phosphatidylcholines	140-159	cut-like homeobox 1	Rattus norvegicus	82-85
23700249-0	2013	Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes.	Phosphatidylcholines	36-55	lysophospholipid acyltransferase 1	Ricinus communis	180-185
23700249-0	2013	Molecular characterization of a lysophosphatidylcholine acyltransferase gene belonging to the MBOAT family in Ricinus communis L. Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) catalyzes acylation of lysophosphatidylcholine (lysoPtdCho) to produce phosphatidylcholine (PtdCho), the main phospholipid in cellular membranes.	Phosphatidylcholines	252-258	lysophospholipid acyltransferase 1	Ricinus communis	130-178
23501167-0	2013	Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p.	Phosphatidylcholines	54-73	lysophospholipase	Saccharomyces cerevisiae S288C	129-134
23749897-5	2013	RESULTS: Sphingomyelin 34:1, phosphatidylcholine (PC) 32:0, and PC 34:1, and PC 36:2 were overexpressed in HER2-positive breast cancer compared to adjacent normal tissue (HER2 signature).	Phosphatidylcholines	29-48	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
23671037-7	2013	Furthermore, (13) C-fatty acid tracing studies indicate that compound K inhibition of DGAT1 increased the production of phosphatidyl choline (PC).	Phosphatidylcholines	120-140	diacylglycerol O-acyltransferase 1	Mus musculus	86-91
23671037-7	2013	Furthermore, (13) C-fatty acid tracing studies indicate that compound K inhibition of DGAT1 increased the production of phosphatidyl choline (PC).	Phosphatidylcholines	142-144	diacylglycerol O-acyltransferase 1	Mus musculus	86-91
23671037-9	2013	DGAT1 inhibition leads to enhanced PC production via alternative carbon channeling.	Phosphatidylcholines	35-37	diacylglycerol O-acyltransferase 1	Mus musculus	0-5
23686420-4	2013	TAG accumulation in sdp1 roots requires both ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) and PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL ACYLTRANSFERASE1 and can also be strongly stimulated by the provision of exogenous sugar.	Phosphatidylcholines	105-124	Patatin-like phospholipase family protein	Arabidopsis thaliana	20-24
23762411-10	2013	Dramatic increases in phosphatidic acid (PA) and decreases in phosphatidylcholine (PC) during ABA-induced senescence were also suppressed in PLDdelta-KO plants.	Phosphatidylcholines	62-81	phospholipase D delta	Arabidopsis thaliana	141-149
23762411-10	2013	Dramatic increases in phosphatidic acid (PA) and decreases in phosphatidylcholine (PC) during ABA-induced senescence were also suppressed in PLDdelta-KO plants.	Phosphatidylcholines	83-85	phospholipase D delta	Arabidopsis thaliana	141-149
23501167-5	2013	The exchange of acyl chains occurred at both the sn-1 and sn-2 positions of the glycerol backbone of PC, and required the phospholipase B Plb1p for optimal efficiency.	Phosphatidylcholines	101-103	lysophospholipase	Saccharomyces cerevisiae S288C	138-143
23501167-6	2013	Sct1p-catalyzed acyl chain exchange, the acyl-CoA binding protein Acb1p, the Plb1p homologue Plb2p, and the glycerophospholipid:triacylglycerol transacylase Lro1p were not required for PC remodeling.	Phosphatidylcholines	185-187	bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1	Saccharomyces cerevisiae S288C	0-5
23474920-0	2013	Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2.	Phosphatidylcholines	70-89	toll like receptor 4	Homo sapiens	15-35
23474920-0	2013	Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2.	Phosphatidylcholines	70-89	lymphocyte antigen 96	Homo sapiens	129-132
23776397-12	2013	The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine.	Phosphatidylcholines	19-21	tumor necrosis factor	Rattus norvegicus	101-110
23776397-12	2013	The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine.	Phosphatidylcholines	19-21	interleukin 6	Rattus norvegicus	115-119
23776397-12	2013	The treatment with PC or HC resulted in a significant attenuation on the increase in serum levels of TNF-alpha and IL-6, pro-inflammatory cytokines, while neither PC nor HC significantly attenuated serum levels of IL-10, anti-inflammatory cytokine.	Phosphatidylcholines	19-21	interleukin 10	Rattus norvegicus	214-219
23456478-8	2013	Although a similar choline-phospholipid efflux is evoked by these apoA-I variants, the change in phosphatidylcholine/sphyngomyelin distribution produced by wild-type apoA-I is not observed with either  K107 or  K226.	Phosphatidylcholines	97-116	apolipoprotein A-I	Cricetulus griseus	166-172
23516040-2	2013	Data were analyzed with a new kinetic model of LCAT activity at interface that exploits the efficiency of LCAT binding to the particle, particle dimensions, and surface concentrations of phosphatidylcholine and cholesterol.	Phosphatidylcholines	187-206	lecithin-cholesterol acyltransferase	Homo sapiens	47-51
23656565-4	2013	Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO).	Phosphatidylcholines	68-88	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	230-234
23656565-4	2013	Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO).	Phosphatidylcholines	68-88	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	239-243
23658780-4	2013	Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin) reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner.	Phosphatidylcholines	262-281	selectin L	Homo sapiens	229-239
23519169-3	2013	Here, we show that plasma membrane (PM)--ER contact sites in yeast are required for phosphatidylcholine synthesis and regulate the activity of the phosphatidylethanolamine N-methyltransferase enzyme, Opi3.	Phosphatidylcholines	84-103	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	200-204
23644991-4	2013	On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid.	Phosphatidylcholines	80-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-54
23644991-4	2013	On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid.	Phosphatidylcholines	80-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
23772401-1	2013	Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	4-23	phospholipase A2 group IB	Rattus norvegicus	88-104
23772401-1	2013	Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	4-23	phospholipase A2 group IB	Rattus norvegicus	106-110
23772401-1	2013	Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	26-28	phospholipase A2 group IB	Rattus norvegicus	88-104
23772401-1	2013	Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	26-28	phospholipase A2 group IB	Rattus norvegicus	106-110
23658780-4	2013	Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin) reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner.	Phosphatidylcholines	262-281	calmodulin 1	Homo sapiens	61-71
23468132-5	2013	The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes.	Phosphatidylcholines	76-95	ATP binding cassette subfamily B member 4	Homo sapiens	18-23
23468132-5	2013	The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes.	Phosphatidylcholines	97-99	ATP binding cassette subfamily B member 4	Homo sapiens	18-23
23468132-6	2013	The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC.	Phosphatidylcholines	29-31	ATP binding cassette subfamily B member 4	Homo sapiens	4-9
23468132-6	2013	The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC.	Phosphatidylcholines	147-149	ATP binding cassette subfamily B member 4	Homo sapiens	4-9
23446897-1	2013	BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA).	Phosphatidylcholines	12-31	phosphatidylethanolamine N-methyltransferase	Homo sapiens	136-140
23613812-0	2013	Human breast cancer tissues contain abundant phosphatidylcholine(36:1) with high stearoyl-CoA desaturase-1 expression.	Phosphatidylcholines	45-64	stearoyl-CoA desaturase	Homo sapiens	81-106
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	16-36
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	38-41
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 11	Homo sapiens	84-90
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 4	Homo sapiens	100-130
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 4	Homo sapiens	132-136
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 4	Homo sapiens	137-142
23446897-1	2013	BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA).	Phosphatidylcholines	33-35	phosphatidylethanolamine N-methyltransferase	Homo sapiens	136-140
23369752-0	2013	GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine.	Phosphatidylcholines	34-53	glycolipid transfer protein	Homo sapiens	0-4
23305784-1	2013	Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile.	Phosphatidylcholines	290-309	ATP binding cassette subfamily B member 1	Homo sapiens	15-19
23305784-1	2013	Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile.	Phosphatidylcholines	290-309	ATP binding cassette subfamily B member 4	Homo sapiens	24-28
23305784-1	2013	Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile.	Phosphatidylcholines	290-309	ATP binding cassette subfamily B member 1	Homo sapiens	209-213
23305784-1	2013	Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile.	Phosphatidylcholines	290-309	ATP binding cassette subfamily B member 4	Homo sapiens	277-281
23271056-4	2013	Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels.	Phosphatidylcholines	86-105	apolipoprotein A1	Homo sapiens	121-127
23271056-4	2013	Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels.	Phosphatidylcholines	86-105	C-C motif chemokine ligand 2	Homo sapiens	189-193
23271056-4	2013	Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels.	Phosphatidylcholines	86-105	C-C motif chemokine ligand 5	Homo sapiens	201-205
23271056-4	2013	Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels.	Phosphatidylcholines	86-105	C-X3-C motif chemokine ligand 1	Homo sapiens	217-223
23349207-2	2013	The overall shape of both particles is discoidal with the low-resolution structure of apoA1 visualized as an open, contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl phosphatidylcholine without cholesterol (nHDL(DMPC)) and two arms in nascent HDL/dimyristoyl phosphatidylcholine with cholesterol (nHDL(DMPC+Chol)).	Phosphatidylcholines	199-218	apolipoprotein A1	Homo sapiens	86-91
23369752-2	2013	Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction.	Phosphatidylcholines	0-19	glycolipid transfer protein	Homo sapiens	240-244
23369752-2	2013	Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction.	Phosphatidylcholines	21-23	glycolipid transfer protein	Homo sapiens	240-244
23585650-5	2013	Lipid profiling revealed that 34C species of phosphatidylglycerol (PG) and monogalactosyl diacylglycerol (MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, lyso-phosphatidylcholine, and phosphatidylserine were higher than the wild type.	Phosphatidylcholines	218-237	16:0delta9 desaturase 2	Arabidopsis thaliana	123-127
23010477-1	2013	The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago.	Phosphatidylcholines	27-46	cut like homeobox 1	Homo sapiens	4-7
23507753-4	2013	Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria.	Phosphatidylcholines	72-91	StAR related lipid transfer domain containing 7	Homo sapiens	29-35
23537027-2	2013	Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation.	Phosphatidylcholines	49-68	procollagen C-endopeptidase enhancer	Homo sapiens	70-72
23537027-2	2013	Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation.	Phosphatidylcholines	49-68	procollagen C-endopeptidase enhancer	Homo sapiens	103-105
22877991-1	2013	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	109-128	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
22877991-1	2013	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	109-128	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
22877991-1	2013	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	130-132	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
22877991-1	2013	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	130-132	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
22903185-9	2013	NTE reduces levels of phosphatidylcholine (PtdCho) by degrading it to glycerophosphocholine and two free fatty acids.	Phosphatidylcholines	22-41	patatin like phospholipase domain containing 6	Homo sapiens	0-3
22903185-9	2013	NTE reduces levels of phosphatidylcholine (PtdCho) by degrading it to glycerophosphocholine and two free fatty acids.	Phosphatidylcholines	43-49	patatin like phospholipase domain containing 6	Homo sapiens	0-3
22903185-10	2013	The substrate for NTE may be nascent PtdCho complexed with a phospholipid-binding protein.	Phosphatidylcholines	37-43	patatin like phospholipase domain containing 6	Homo sapiens	18-21
23448237-10	2013	As recombinant ACBP1 binds phosphatidic acid and phosphatidylcholine, ACBP1 probably promotes PLDalpha1 action.	Phosphatidylcholines	49-68	acyl-CoA binding protein 1	Arabidopsis thaliana	15-20
23448237-10	2013	As recombinant ACBP1 binds phosphatidic acid and phosphatidylcholine, ACBP1 probably promotes PLDalpha1 action.	Phosphatidylcholines	49-68	phospholipase D alpha 1	Arabidopsis thaliana	94-103
23505262-0	2013	Retraction: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.	Phosphatidylcholines	47-66	cut like homeobox 1	Homo sapiens	12-15
23505262-0	2013	Retraction: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.	Phosphatidylcholines	47-66	phospholipase A2 group IB	Homo sapiens	102-163
23349189-2	2013	Group X sPLA2 (PLA2G10) has the most potent hydrolyzing activity toward phosphatidylcholine and is believed to play a proatherogenic role.	Phosphatidylcholines	72-91	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	8-13
23349189-2	2013	Group X sPLA2 (PLA2G10) has the most potent hydrolyzing activity toward phosphatidylcholine and is believed to play a proatherogenic role.	Phosphatidylcholines	72-91	phospholipase A2, group X	Mus musculus	15-22
22903185-11	2013	Protein kinase A-mediated phosphorylation enhances PtdCho synthesis and may allow PtdCho accumulation by coordinate inhibition of NTE activity.	Phosphatidylcholines	82-88	patatin like phospholipase domain containing 6	Homo sapiens	130-133
23010477-1	2013	The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago.	Phosphatidylcholines	48-54	cut like homeobox 1	Homo sapiens	4-7
23010477-6	2013	Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle.	Phosphatidylcholines	10-16	patatin like phospholipase domain containing 6	Homo sapiens	56-82
23010477-6	2013	Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle.	Phosphatidylcholines	10-16	cut like homeobox 1	Homo sapiens	113-116
23269393-9	2013	The hypertonic upregulation of phosphatidylcholine (PC) synthesis, the main constituent of all cell membranes, involved the transcriptional activation of two main regulatory enzymes, choline kinase (CK) and cytidylyltransferase alpha (CCTalpha) and required ERK1/2 activation.	Phosphatidylcholines	31-50	mitogen-activated protein kinase 1	Canis lupus familiaris	258-264
23262193-3	2013	We have recently shown that the C2 domain of MFG-E8 bears more specificity toward PS when compared with phosphatidylcholine (PC), another phospholipid thought to be involved in the immune function of phagocytes.	Phosphatidylcholines	125-127	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	45-51
23266496-1	2013	Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry.	Phosphatidylcholines	75-94	cytochrome c, somatic	Homo sapiens	20-32
23266496-1	2013	Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry.	Phosphatidylcholines	75-94	cytochrome c, somatic	Homo sapiens	34-39
23266496-1	2013	Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry.	Phosphatidylcholines	96-98	cytochrome c, somatic	Homo sapiens	20-32
23266496-1	2013	Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry.	Phosphatidylcholines	96-98	cytochrome c, somatic	Homo sapiens	34-39
23277511-1	2013	Group IVA cytosolic phospholipase A2 (cPLA2alpha), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine.	Phosphatidylcholines	215-234	phospholipase A2 group IVA	Homo sapiens	38-48
23269393-9	2013	The hypertonic upregulation of phosphatidylcholine (PC) synthesis, the main constituent of all cell membranes, involved the transcriptional activation of two main regulatory enzymes, choline kinase (CK) and cytidylyltransferase alpha (CCTalpha) and required ERK1/2 activation.	Phosphatidylcholines	52-54	mitogen-activated protein kinase 1	Canis lupus familiaris	258-264
22982257-10	2013	Comparing these results to those obtained with the same kind of SLN without PC and/or Chol, it is possible to conclude that the addition of Chol and/or PC to the composition of cationic SLN modify the cell tolerance and the transfection efficiency of the gene vector in a manner strictly dependent on the cell type and the internalization pathways.	Phosphatidylcholines	152-154	sarcolipin	Homo sapiens	186-189
23200860-1	2013	STARD10, a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) protein family, is highly expressed in the liver and has been shown to transfer phosphatidylcholine.	Phosphatidylcholines	182-201	START domain containing 10	Mus musculus	0-7
23044079-8	2013	In addition, the phosphatidylcholine/phosphatidylethanolamine liver ratio decrease was less important in TNF(-/-) mice.	Phosphatidylcholines	17-36	tumor necrosis factor	Mus musculus	105-108
22982257-3	2013	In this paper SLN were prepared using stearic acid as main lipid component, stearylamine as cationic agent and protamine as transfection promoter and adding phosphatidylcholine (PC), cholesterol (Chol) or both to obtain three different multicomponent SLN (SLN-PC, SLN-Chol and SLN-PC-Chol, respectively).	Phosphatidylcholines	157-176	sarcolipin	Homo sapiens	14-17
22982257-3	2013	In this paper SLN were prepared using stearic acid as main lipid component, stearylamine as cationic agent and protamine as transfection promoter and adding phosphatidylcholine (PC), cholesterol (Chol) or both to obtain three different multicomponent SLN (SLN-PC, SLN-Chol and SLN-PC-Chol, respectively).	Phosphatidylcholines	178-180	sarcolipin	Homo sapiens	14-17
23032700-9	2013	These data indicate that cobalamin mediates down-regulation of Multidrug Resistance-1 gene expression through increased S-adenosyl-methionine and phosphatidylcholine productions and phospholipase D activation.	Phosphatidylcholines	146-165	ATP binding cassette subfamily B member 1	Homo sapiens	63-85
23420493-1	2013	Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases.	Phosphatidylcholines	118-137	phospholipase A2 group IID	Homo sapiens	10-37
23420493-1	2013	Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases.	Phosphatidylcholines	118-137	phospholipase A2 group IID	Homo sapiens	39-44
23420493-1	2013	Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases.	Phosphatidylcholines	118-137	phospholipase A2 group IID	Homo sapiens	47-52
23074091-0	2013	Phosphatidylcholine enrichment with medium chain fatty acids by immobilized phospholipase A(1) -catalyzed acidolysis.	Phosphatidylcholines	0-19	lipase H	Homo sapiens	76-94
23155050-2	2013	As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation.	Phosphatidylcholines	59-61	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	73-118
23155050-2	2013	As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation.	Phosphatidylcholines	59-61	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	120-128
23452035-8	2013	Likewise, asthma risk alleles from the PDED3 and MED24 genes at the asthma susceptibility locus 17q21 were associated with increased concentrations of various phosphatidylcholines with consistent effect directions.	Phosphatidylcholines	159-179	mediator complex subunit 24	Homo sapiens	49-54
23193974-7	2013	Furthermore, the phospholipid composition markedly influences P450 turnover and b(5) stimulation and specificity, particularly for CYP17A1, in the following order: phosphatidylserine &gt; phosphatidylethanolamine &gt; phosphatidylcholine.	Phosphatidylcholines	218-237	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	131-138
23074091-2	2013	In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568.	Phosphatidylcholines	15-34	lipase H	Homo sapiens	110-128
23074091-2	2013	In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568.	Phosphatidylcholines	15-34	lipase H	Homo sapiens	130-136
23074091-2	2013	In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568.	Phosphatidylcholines	36-38	lipase H	Homo sapiens	110-128
23074091-2	2013	In this study, phosphatidylcholine (PC) was enriched with medium-chain fatty acids (MCFAs) by acidolysis with phospholipase A(1) (PLA(1) ) immobilized on Duolite A568.	Phosphatidylcholines	36-38	lipase H	Homo sapiens	130-136
24068966-2	2013	By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1).	Phosphatidylcholines	88-107	Progestin and AdipoQ Receptor family	Caenorhabditis elegans	23-29
23746278-3	2013	When the phosphatidylcholine-polymer-coated peptide microarray was applied to the analysis of the kinome of HCC827 cells, hyperactivation of c-Src and EGFR were successfully detected.	Phosphatidylcholines	9-28	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	141-146
23746278-3	2013	When the phosphatidylcholine-polymer-coated peptide microarray was applied to the analysis of the kinome of HCC827 cells, hyperactivation of c-Src and EGFR were successfully detected.	Phosphatidylcholines	9-28	epidermal growth factor receptor	Homo sapiens	151-155
23681536-5	2013	Here we provide four variations of in vitro PLD activity assays using choline-labeled phosphatidylcholine to distinguish, to the extent possible, among the different PLD classes.	Phosphatidylcholines	86-105	phospholipase D alpha 1	Arabidopsis thaliana	44-47
23681537-1	2013	Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine.	Phosphatidylcholines	63-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
23681537-1	2013	Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine.	Phosphatidylcholines	63-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
23681537-1	2013	Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine.	Phosphatidylcholines	84-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
23681537-1	2013	Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine.	Phosphatidylcholines	84-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
24068966-2	2013	By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1).	Phosphatidylcholines	88-107	Choline/EthanolaminePhosphoTransferase	Caenorhabditis elegans	119-125
24068966-2	2013	By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1).	Phosphatidylcholines	88-107	CTP_transf_like domain-containing protein;Putative choline-phosphate cytidylyltransferase	Caenorhabditis elegans	127-133
24068966-2	2013	By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1).	Phosphatidylcholines	88-107	putative S-adenosylmethionine synthase 1	Caenorhabditis elegans	138-144
23555755-5	2013	Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120.	Phosphatidylcholines	9-28	C-C motif chemokine ligand 2	Homo sapiens	118-122
23555755-5	2013	Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120.	Phosphatidylcholines	9-28	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	145-150
23555755-5	2013	Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120.	Phosphatidylcholines	9-28	mitogen-activated protein kinase 3	Homo sapiens	179-185
23555755-5	2013	Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120.	Phosphatidylcholines	9-28	phospholipase C beta 1	Homo sapiens	201-207
23555755-5	2013	Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120.	Phosphatidylcholines	9-28	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	246-251
23451176-4	2013	Immunohistochemistry of obese normal, SS and NASH liver specimens with anti-phosphatidylethanomine N-methyltransferase (PEMT) antibodies showed a progressive decrease in the zonal distribution of this PC biosynthetic enzyme.	Phosphatidylcholines	201-203	phosphatidylethanolamine N-methyltransferase	Homo sapiens	71-118
23451176-4	2013	Immunohistochemistry of obese normal, SS and NASH liver specimens with anti-phosphatidylethanomine N-methyltransferase (PEMT) antibodies showed a progressive decrease in the zonal distribution of this PC biosynthetic enzyme.	Phosphatidylcholines	201-203	phosphatidylethanolamine N-methyltransferase	Homo sapiens	120-124
22970809-2	2012	Although Ybt1p was originally identified as a bile acid transporter, it has also been found to function in other capacities, including the translocation of phosphatidylcholine to the vacuole lumen, and the regulation of Ca2+ homoeostasis.	Phosphatidylcholines	156-175	bile acid-transporting ATPase YBT1	Saccharomyces cerevisiae S288C	9-14
24291895-2	2013	Based upon the similarity in the pathological features to rmd mouse which has a recessive mutation in Chkb gene encoding the choline kinase beta that catalyzes first enzymatic step in a biosynthetic pathway for phosphatidylcholine, we have sequenced the CHKB gene in 15 patients with the disease and identified identified biallelic mutations in all patients.	Phosphatidylcholines	211-230	choline kinase beta	Mus musculus	102-106
24291895-2	2013	Based upon the similarity in the pathological features to rmd mouse which has a recessive mutation in Chkb gene encoding the choline kinase beta that catalyzes first enzymatic step in a biosynthetic pathway for phosphatidylcholine, we have sequenced the CHKB gene in 15 patients with the disease and identified identified biallelic mutations in all patients.	Phosphatidylcholines	211-230	choline kinase beta	Mus musculus	125-144
23043861-6	2012	Phosphatidylcholine vesicles containing C2-DE-C1P reduced cPLA(2)alpha activity in vitro.	Phosphatidylcholines	0-19	phospholipase A2 group IVA	Homo sapiens	58-70
23091059-6	2012	Both cholesterol and sphingomyelin were required for the formation of TCR dimers in phosphatidylcholine-containing large unilamellar vesicles.	Phosphatidylcholines	84-103	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	70-73
22921758-3	2012	RVVA-PLA2-I preferentially hydrolyzed phospholipids (phosphatidylcholine) of erythrocyte membrane compared to the liver mitochondrial membrane.	Phosphatidylcholines	53-72	phospholipase A2, group V	Mus musculus	5-9
23148485-1	2012	Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC).	Phosphatidylcholines	318-338	phospholipase A2 group VII	Homo sapiens	19-60
23148485-1	2012	Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC).	Phosphatidylcholines	318-338	phospholipase A2 group VII	Homo sapiens	62-71
23148485-1	2012	Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC).	Phosphatidylcholines	340-342	phospholipase A2 group VII	Homo sapiens	19-60
23148485-1	2012	Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC).	Phosphatidylcholines	340-342	phospholipase A2 group VII	Homo sapiens	62-71
22921758-8	2012	Our study advocates that the presence of a large number of PLA2-sensitive phospholipid domains/composition, rather than only the phosphatidylcholine (PC) content of that particular membrane may determine the extent of membrane damage by a particular venom PLA2 enzyme.	Phosphatidylcholines	129-148	phospholipase A2, group V	Mus musculus	256-260
22991194-2	2012	It is well established that cPLA(2)alpha binds zwitterionic lipids such as phosphatidylcholine in a Ca(2+)-dependent manner through its N-terminal C2 domain, which regulates its translocation to cellular membranes.	Phosphatidylcholines	75-94	phospholipase A2 group IVA	Homo sapiens	28-40
23000394-0	2012	Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells.	Phosphatidylcholines	0-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	45-66
23000394-0	2012	Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells.	Phosphatidylcholines	0-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	68-73
23000394-0	2012	Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells.	Phosphatidylcholines	0-19	BTG anti-proliferation factor 2	Rattus norvegicus	96-123
22622287-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid.	Phosphatidylcholines	94-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-55
22888116-5	2012	Furthermore, phosphatidylcholine increased the binding affinity of the substrates to the CYP1B1.	Phosphatidylcholines	13-32	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	89-95
22988242-1	2012	CTP:phosphocholine cytidylyltransferase (CCT), an amphitropic enzyme that regulates phosphatidylcholine synthesis, is composed of a catalytic head domain and a regulatory tail.	Phosphatidylcholines	84-103	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
22988242-1	2012	CTP:phosphocholine cytidylyltransferase (CCT), an amphitropic enzyme that regulates phosphatidylcholine synthesis, is composed of a catalytic head domain and a regulatory tail.	Phosphatidylcholines	84-103	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	41-44
22622287-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid.	Phosphatidylcholines	94-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
23032920-5	2012	The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases.	Phosphatidylcholines	13-33	amyloid beta precursor protein	Rattus norvegicus	63-68
22824913-1	2012	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
22824913-1	2012	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
23032920-5	2012	The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases.	Phosphatidylcholines	13-33	phospholipase A2 group IB	Rattus norvegicus	146-164
23032920-5	2012	The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases.	Phosphatidylcholines	35-38	amyloid beta precursor protein	Rattus norvegicus	63-68
23032920-5	2012	The elevated phosphatidylcholines (PCs) levels observed in the Abeta-treated PC12 cells were quite probably the integrated results of the reduced phospholipase A(2) (PLA(2)) activity and the enhanced activity of lysophospholipid acyltransferases.	Phosphatidylcholines	35-38	phospholipase A2 group IB	Rattus norvegicus	146-164
22819818-5	2012	Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation.	Phosphatidylcholines	0-19	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	109-114
22221492-5	2012	Compared to the control group, significant increases of DHA, EPA+DHA and total n-3 PUFA in plasma choline phosphoglyceride were observed in the three oily fish groups.	Phosphatidylcholines	98-122	pumilio RNA binding family member 3	Homo sapiens	83-87
23038705-5	2012	Tunicamycin administration induced BiP/GRP78 and GRP94 expression more potently in the p53-deficient mice than in controls and elevated phosphatidylcholine, the major lipid of ER, by a p53-dependent mechanism.	Phosphatidylcholines	136-155	transformation related protein 53, pseudogene	Mus musculus	185-188
22743636-1	2012	Group V secretory phospholipase A2 (sPLA2-V) hydrolyzes phosphatidylcholine in low-density lipoprotein (LDL) to increase lysophosphatidylcholine (LPC) content.	Phosphatidylcholines	56-75	phospholipase A2 group X	Homo sapiens	36-41
22607224-7	2012	Efflux to PC-containing rHDL was stimulated by transfection of a nonfunctional ABCA1 mutant (W590S), suggesting that binding to ABCA1 represents a competing interaction.	Phosphatidylcholines	10-12	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	79-84
22607224-7	2012	Efflux to PC-containing rHDL was stimulated by transfection of a nonfunctional ABCA1 mutant (W590S), suggesting that binding to ABCA1 represents a competing interaction.	Phosphatidylcholines	10-12	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	128-133
23074967-2	2012	Cytidine triphosphate (CTP):phosphocholine cytidylyltransferase alpha (CTalpha) regulates the primary pathway of PC biosynthesis in the liver.	Phosphatidylcholines	113-115	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	71-78
22819818-5	2012	Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation.	Phosphatidylcholines	0-19	tumor necrosis factor	Mus musculus	118-127
22819818-5	2012	Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation.	Phosphatidylcholines	0-19	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	168-205
22819818-5	2012	Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-alpha, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation.	Phosphatidylcholines	0-19	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	207-213
22995497-7	2012	Finally, our measurements suggest an unexpectedly strong preferential enrichment of the anionic lipid phosphatidylglycerol around the cationic KALP peptide in ternary mixtures with PC.	Phosphatidylcholines	181-183	anosmin 2, pseudogene	Homo sapiens	143-147
22822086-2	2012	The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule.	Phosphatidylcholines	205-224	phosphatidylinositol transfer protein alpha	Homo sapiens	62-71
22822086-2	2012	The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule.	Phosphatidylcholines	205-224	phosphatidylinositol transfer protein alpha	Homo sapiens	73-79
22822086-2	2012	The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule.	Phosphatidylcholines	205-224	phosphatidylinositol transfer protein beta	Homo sapiens	85-93
22822086-2	2012	The best characterized mammalian PITPs are the Class I PITPs, PITPalpha (PITPNA) and PITPbeta (PITPNB), which are single domain proteins with a hydrophobic cavity that binds a phosphatidylinositol (PI) or phosphatidylcholine molecule.	Phosphatidylcholines	205-224	phosphatidylinositol transfer protein beta	Homo sapiens	95-101
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylcholines	129-148	microtubule associated protein tau	Homo sapiens	74-77
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylcholines	129-148	keratin 19	Homo sapiens	84-87
22539676-6	2012	Similarly to BSP proteins from other species, rec-BSPH1 bound to gelatin, heparin, phosphatidylcholine liposomes, and sperm.	Phosphatidylcholines	83-102	binder of sperm protein homolog 1	Mus musculus	50-55
23141892-2	2012	It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile.	Phosphatidylcholines	156-175	ATP binding cassette subfamily B member 4	Homo sapiens	39-44
23141892-2	2012	It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile.	Phosphatidylcholines	156-175	ATP binding cassette subfamily B member 4	Homo sapiens	84-89
23141892-2	2012	It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile.	Phosphatidylcholines	156-175	ATP binding cassette subfamily B member 4	Homo sapiens	90-94
22583846-2	2012	First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, solubility study, TEM, etc.	Phosphatidylcholines	68-87	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	169-172
22583846-2	2012	First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, solubility study, TEM, etc.	Phosphatidylcholines	135-154	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	169-172
22706677-2	2012	We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages.	Phosphatidylcholines	99-118	phospholipase A2 group X	Homo sapiens	38-45
22706677-2	2012	We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages.	Phosphatidylcholines	99-118	phospholipase A2 group X	Homo sapiens	47-56
22609605-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	94-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-55
22609605-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	94-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
22609605-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	115-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-55
22609605-2	2012	At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	115-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
22791820-1	2012	In Arabidopsis thaliana, XIPOTL1 encodes a phosphoethanolamine N-methyltransferase with a central role in phosphatidylcholine biosynthesis via the methylation pathway.	Phosphatidylcholines	106-125	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	25-32
22683603-7	2012	Furthermore, when cyt c was associated with liposomes composed of cardiolipin/phosphatidylcholine, and incubated with RNA and H(2)O(2), it was found cross-linked with the oxidized RNA and dissociated from the liposome.	Phosphatidylcholines	78-97	cytochrome c, somatic	Homo sapiens	18-23
24027600-1	2012	It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes.	Phosphatidylcholines	43-62	C-reactive protein	Homo sapiens	85-103
24027600-1	2012	It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes.	Phosphatidylcholines	43-62	C-reactive protein	Homo sapiens	105-108
24027600-1	2012	It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes.	Phosphatidylcholines	64-66	C-reactive protein	Homo sapiens	85-103
24027600-1	2012	It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes.	Phosphatidylcholines	64-66	C-reactive protein	Homo sapiens	105-108
22465066-2	2012	In the present study we have re-evaluated lipid-protein interactions of SP-B by analysing Forster resonance energy transfer (FRET) efficiencies, obtained from time-resolved measurements, from the single tryptophan in SP-B to different fluorescently labelled phospholipids in matrix bilayers made of either pure phosphatidylcholine (POPC) or the full lipid extract obtained from purified surfactant.	Phosphatidylcholines	311-330	surfactant protein B	Homo sapiens	72-76
22730894-5	2012	Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain.	Phosphatidylcholines	91-110	apolipoprotein E	Homo sapiens	78-83
22730894-5	2012	Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain.	Phosphatidylcholines	91-110	apolipoprotein E	Homo sapiens	181-186
22465066-2	2012	In the present study we have re-evaluated lipid-protein interactions of SP-B by analysing Forster resonance energy transfer (FRET) efficiencies, obtained from time-resolved measurements, from the single tryptophan in SP-B to different fluorescently labelled phospholipids in matrix bilayers made of either pure phosphatidylcholine (POPC) or the full lipid extract obtained from purified surfactant.	Phosphatidylcholines	332-336	surfactant protein B	Homo sapiens	72-76
22511767-3	2012	One key enzyme in the Lands" cycle is fatty acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT), which utilizes lysophosphatidylcholine (LysoPC) and fatty acyl-CoA to produce various phosphatidylcholine (PC) species.	Phosphatidylcholines	57-76	lysophosphatidylcholine acyltransferase 3	Mus musculus	94-99
23075452-3	2012	While the cellular phosphatidylethanolamine (PE) content remained unaltered, cellular phosphatidylcholine (PC)-, LPC- and TG-contents were significantly increased upon EL overexpression.	Phosphatidylcholines	86-105	lipase, endothelial	Mus musculus	168-170
23075452-3	2012	While the cellular phosphatidylethanolamine (PE) content remained unaltered, cellular phosphatidylcholine (PC)-, LPC- and TG-contents were significantly increased upon EL overexpression.	Phosphatidylcholines	107-109	lipase, endothelial	Mus musculus	168-170
23075452-8	2012	Incorporation of [(3)H]-Choline into cellular PC was 56% lower in EL compared with LacZ cells, indicating decreased endogenous PC synthesis.	Phosphatidylcholines	46-48	lipase, endothelial	Mus musculus	66-68
23075452-10	2012	Based on our results, we conclude that EL not only supplies cells with FFA as found previously, but also with HDL-derived LPC and LPE species resulting in increased cellular TG and PC content as well as decreased endogenous PC synthesis.	Phosphatidylcholines	123-125	lipase, endothelial	Mus musculus	39-41
23075452-10	2012	Based on our results, we conclude that EL not only supplies cells with FFA as found previously, but also with HDL-derived LPC and LPE species resulting in increased cellular TG and PC content as well as decreased endogenous PC synthesis.	Phosphatidylcholines	181-183	lipase, endothelial	Mus musculus	39-41
22511767-3	2012	One key enzyme in the Lands" cycle is fatty acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT), which utilizes lysophosphatidylcholine (LysoPC) and fatty acyl-CoA to produce various phosphatidylcholine (PC) species.	Phosphatidylcholines	95-97	lysophosphatidylcholine acyltransferase 3	Mus musculus	44-92
22494626-2	2012	Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins.	Phosphatidylcholines	91-110	phospholipase A2 group IID	Homo sapiens	6-14
22676268-0	2012	Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell.	Phosphatidylcholines	0-19	lysophosphatidylcholine acyltransferase 1	Homo sapiens	33-39
22676268-2	2012	De-acylated lipids are then re-acylated by lysophospholipid acyltransferase enzymes such as LPCAT1 which catalyses the formation of phosphatidylcholine (PC) from lysoPC and long-chain acyl-CoA.	Phosphatidylcholines	132-151	lysophosphatidylcholine acyltransferase 1	Homo sapiens	92-98
22173044-5	2012	RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC).	Phosphatidylcholines	176-195	phospholipase A2 group IIA	Homo sapiens	13-18
22173044-5	2012	RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC).	Phosphatidylcholines	197-199	phospholipase A2 group IIA	Homo sapiens	13-18
22494626-2	2012	Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins.	Phosphatidylcholines	91-110	phospholipase A2 group IIA	Homo sapiens	6-13
22494626-2	2012	Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins.	Phosphatidylcholines	112-114	phospholipase A2 group IID	Homo sapiens	6-14
22494626-2	2012	Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins.	Phosphatidylcholines	112-114	phospholipase A2 group IIA	Homo sapiens	6-13
22647268-2	2012	The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	104-123	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	132-154
22647268-2	2012	The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	104-123	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	156-160
22647268-2	2012	The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	125-127	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	132-154
22647268-2	2012	The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	125-127	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	156-160
22647268-3	2012	It has been suggested that PC synthesis by PEMT plays an important role in the transport of polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) from the liver to plasma and possibly other tissues.	Phosphatidylcholines	27-29	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	43-47
22403410-9	2012	Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	151-170	Ups1p	Saccharomyces cerevisiae S288C	67-72
22860206-6	2012	Among different phospholipids tested, choline- or ethanolamine-containing phospholipids showed potent effects, and 1 mM phosphatidylcholine increased NAAA activity by 6.6-fold.	Phosphatidylcholines	120-139	N-acylethanolamine acid amidase	Mus musculus	150-154
22403410-9	2012	Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	151-170	Ups2p	Saccharomyces cerevisiae S288C	77-82
22333571-0	2012	Distinction between phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) and phosphatidylinositol (PI)-specific phospolipase C (PI-PLC) needs clarification.	Phosphatidylcholines	41-43	heparan sulfate proteoglycan 2	Homo sapiens	74-77
22430035-2	2012	We reconstituted the catalytic core of the human neutrophil NADPH oxidase, flavocytochrome b (Cyt b) in 99% phosphatidylcholine vesicles in order to correlate anionic lipid-dependent conformational changes in membrane-bound Cyt b and oxidase activity.	Phosphatidylcholines	108-127	mitochondrially encoded cytochrome b	Homo sapiens	94-99
22226181-11	2012	IMS revealed an abnormal accumulation of lysophosphatidylcholine (LPC; 1-acyl 16:0) and phosphatidylcholine (diacyl 16:0/20:4) in the VV intima and media.	Phosphatidylcholines	45-64	annexin A1	Homo sapiens	66-72
22278967-1	2012	Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine, the major phospholipid in eukaryotic cell membranes.	Phosphatidylcholines	86-105	cut like homeobox 1	Homo sapiens	49-52
22859919-4	2012	There are two mechanisms to protect the canalicular membrane from solubilization by bile salts; ABCB4 secretes phosphatidylcholine into bile to form mixed micelles with bile salts, and ATP8B1 maintains the canalicular membrane in a liquid-ordered state.	Phosphatidylcholines	111-130	ATP binding cassette subfamily B member 4	Homo sapiens	96-101
22015962-3	2012	Here we show that an unusual phosphatidylcholine species with two saturated 12 carbon fatty acid acyl sidechains (dilauroyl phosphatidylcholine (DLPC)) is an LRH-1 agonist ligand in vitro.	Phosphatidylcholines	29-48	nuclear receptor subfamily 5, group A, member 2	Mus musculus	158-163
22015962-7	2012	These findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis.	Phosphatidylcholines	43-62	nuclear receptor subfamily 5, group A, member 2	Mus musculus	27-32
22212660-1	2012	Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling.	Phosphatidylcholines	27-47	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
22212660-1	2012	Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling.	Phosphatidylcholines	27-47	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
22212660-1	2012	Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling.	Phosphatidylcholines	49-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
22212660-1	2012	Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling.	Phosphatidylcholines	49-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
22167755-5	2012	We identified phosphatidylcholine (PCh) as the major phospholipid bound to human soluble EPCR (sEPCR).	Phosphatidylcholines	14-33	protein C receptor	Homo sapiens	89-93
22167755-5	2012	We identified phosphatidylcholine (PCh) as the major phospholipid bound to human soluble EPCR (sEPCR).	Phosphatidylcholines	35-38	protein C receptor	Homo sapiens	89-93
22167755-6	2012	PCh in EPCR could be exchanged for lysophosphatidylcholine (lysoPCh) and platelet activating factor (PAF).	Phosphatidylcholines	0-3	protein C receptor	Homo sapiens	7-11
22407999-7	2012	Thereby, flow cytometry revealed high cellular association and internalization of anti-IGF1-R immunoliposomes (soy phosphatidylcholine (SPC)/cholesterol (Chol)-polyethyleneglycol (PEG)-1H7, 50.1+-2.2%).	Phosphatidylcholines	115-134	insulin like growth factor 1 receptor	Homo sapiens	87-93
22101393-2	2012	D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC).	Phosphatidylcholines	49-68	heparan sulfate proteoglycan 2	Homo sapiens	103-106
22101393-2	2012	D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC).	Phosphatidylcholines	70-72	heparan sulfate proteoglycan 2	Homo sapiens	103-106
22101976-0	2012	Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine.	Phosphatidylcholines	95-114	catalase-3	Glycine max	36-44
21822308-5	2012	The first enzyme of the phosphatidyl choline production pathway, CHKA, is overexpressed in many cancers, and the product of the enzyme, phosphocholine, is also increased in tumor cells.	Phosphatidylcholines	24-44	choline kinase alpha	Homo sapiens	65-69
23449275-7	2012	C-reactive protein showed positive correlations with phosphatidylcholine, phosphatidylserine, phosphatidylinositol and total phospholipids in membranes from control subjects.	Phosphatidylcholines	53-72	C-reactive protein	Homo sapiens	0-18
22358145-1	2012	The combination of data obtained from isothermal mixing calorimetry and light scattering allowed us to reveal the relationships between the character of the interactions of casein (beta-casein and sodium caseinate (SCN) particles) with phosphatidylcholine (PC) liposomes and their specific properties, such as, the hydrophilic-lipophilic balance of the surface properties, the size, and the architecture.	Phosphatidylcholines	236-255	casein beta	Homo sapiens	181-192
22223861-4	2012	Lack of L-FABP selectively increased cholesterol, phospholipid (especially phosphatidylcholine), and branched-chain FA accumulation in the cholesterol-rich microdomains.	Phosphatidylcholines	75-94	fatty acid binding protein 1	Homo sapiens	8-14
22308393-3	2012	Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	167-186	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	84-88
22184139-1	2012	The ATP-binding cassette transporter ABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous to the multidrug transporter ABCB1.	Phosphatidylcholines	48-67	ATP binding cassette subfamily B member 4	Canis lupus familiaris	37-42
22184139-1	2012	The ATP-binding cassette transporter ABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous to the multidrug transporter ABCB1.	Phosphatidylcholines	48-67	ATP binding cassette subfamily B member 1	Canis lupus familiaris	200-205
22308393-3	2012	Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	167-186	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	93-97
22070544-8	2012	LC-MS based lipidomic analysis identified significantly higher levels of phospholipids, especially phosphatidylcholines in GPAM protein positive tumors.	Phosphatidylcholines	99-119	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	123-127
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylcholines	116-118	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	56-60
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylcholines	116-118	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	66-70
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylcholines	116-118	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	106-110
22079326-3	2012	To investigate whether a reduced PC:PE ratio influences cellular growth and apoptosis, we utilized the MT58 cell line, which contains a thermo-sensitive mutation in CTP:phosphocholine cytidylyltransferase-alpha, the rate-limiting enzyme for PC biosynthesis.	Phosphatidylcholines	241-243	choline-phosphate cytidylyltransferase A	Cricetulus griseus	165-210
22101258-1	2012	BACKGROUND: Lysophosphatidylcholine acyltransferase 1 (LPCAT1), the enzyme catalyzing the reaction in remodeling of phosphatidylcholine (PC) has been reported to express in prostate.	Phosphatidylcholines	16-35	lysophosphatidylcholine acyltransferase 1	Homo sapiens	55-61
22101258-1	2012	BACKGROUND: Lysophosphatidylcholine acyltransferase 1 (LPCAT1), the enzyme catalyzing the reaction in remodeling of phosphatidylcholine (PC) has been reported to express in prostate.	Phosphatidylcholines	56-58	lysophosphatidylcholine acyltransferase 1	Homo sapiens	12-53
23049600-2	2012	This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy.	Phosphatidylcholines	92-111	pumilio RNA binding family member 3	Homo sapiens	53-57
22128164-10	2012	PAH1-encoded phosphatidate phosphatase catalyzes the penultimate step in triacylglycerol synthesis, and the diacylglycerol generated in the reaction may also be used for phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	170-189	phosphatidate phosphatase PAH1	Saccharomyces cerevisiae S288C	0-4
22037357-8	2012	When supplemented into pure lipid vesicles and monomolecular films composed of PG and PC mixtures, SP-B also inhibited hydrolysis by both PLA2G1B and Group IIA sPLA2 (PLA2G2A).	Phosphatidylcholines	86-88	surfactant protein B	Bos taurus	99-103
22679365-2	2012	METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA, leading to the formation of a thioether bond between free SH-groups of the polymer and maleimide groups of the liposome.	Phosphatidylcholines	33-52	T-box transcription factor 1	Homo sapiens	126-129
21968070-3	2012	The accumulation of PUFAs in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine correlated with an induced lysophosphatidic acid acyltransferase (LPAAT)3 mRNA expression, increased microsomal LPAAT3 activity, and shift of LPAAT specificity to PUFA-coenzyme A.	Phosphatidylcholines	29-48	1-acylglycerol-3-phosphate O-acyltransferase 3	Mus musculus	165-172
22679365-2	2012	METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA, leading to the formation of a thioether bond between free SH-groups of the polymer and maleimide groups of the liposome.	Phosphatidylcholines	54-58	T-box transcription factor 1	Homo sapiens	126-129
22348006-4	2012	METHODOLOGY: We used isothermal titration calorimetry (ITC) and enzyme-linked immunosorbent assay (ELISA) to examine binding of Stx1 and Stx2 to various glycans, glycosphingolipids, and glycosphingolipid mixtures in the presence or absence of membrane components, phosphatidylcholine, and cholesterol.	Phosphatidylcholines	264-283	syntaxin-2	Chlorocebus sabaeus	137-141
22768255-7	2012	In particular, short chain saturated fatty acids and the phosphatidylcholine (PC) lipids into which these fatty acids are incorporated were specifically reduced by Nampt inhibition.	Phosphatidylcholines	57-76	nicotinamide phosphoribosyltransferase	Homo sapiens	164-169
22768255-7	2012	In particular, short chain saturated fatty acids and the phosphatidylcholine (PC) lipids into which these fatty acids are incorporated were specifically reduced by Nampt inhibition.	Phosphatidylcholines	78-80	nicotinamide phosphoribosyltransferase	Homo sapiens	164-169
22348006-9	2012	In the presence of phosphatidylcholine and cholesterol, both Stx1 and Stx2 bound well to Gb3 or Gb4 alone or mixed with other neutral glycolipids.	Phosphatidylcholines	19-38	syntaxin-2	Chlorocebus sabaeus	70-74
22348006-9	2012	In the presence of phosphatidylcholine and cholesterol, both Stx1 and Stx2 bound well to Gb3 or Gb4 alone or mixed with other neutral glycolipids.	Phosphatidylcholines	19-38	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	89-92
22348006-10	2012	Pre-incubation with Gb3 in the presence of phosphatidylcholine and cholesterol neutralized Stx1, but not Stx2 toxicity to Vero cells.	Phosphatidylcholines	43-62	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	20-23
21908590-0	2011	An albumin-associated PLA2-like activity inactivates surfactant phosphatidylcholine secreted from fetal type II pneumocytes.	Phosphatidylcholines	64-83	phospholipase A2 group IIA	Homo sapiens	22-26
21958442-0	2011	The role of glycerol and phosphatidylcholine in solubilizing and enhancing insulin stability in reverse hexagonal mesophases.	Phosphatidylcholines	25-44	insulin	Homo sapiens	75-82
21958070-3	2011	Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	46-65	phosphatidylethanolamine N-methyltransferase	Sus scrofa	87-131
21745592-2	2011	CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis.	Phosphatidylcholines	106-108	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-40
21745592-2	2011	CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis.	Phosphatidylcholines	106-108	cut-like homeobox 1	Mus musculus	82-85
22020259-9	2011	A similar BRSK1-activating effect was obtained with synthetic SMV made with phosphatidylcholine, cholesterol and sphingomyelin, mixed in the same molar ratio at which these three major lipids are present in rafts.	Phosphatidylcholines	76-95	BR serine/threonine kinase 1	Homo sapiens	10-15
21958070-3	2011	Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	46-65	phosphatidylethanolamine N-methyltransferase	Sus scrofa	133-137
21958070-3	2011	Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	67-69	phosphatidylethanolamine N-methyltransferase	Sus scrofa	87-131
21958070-3	2011	Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	67-69	phosphatidylethanolamine N-methyltransferase	Sus scrofa	133-137
21958070-5	2011	By using enzymatic assays, we showed that the expression of PEMT increased the cellular PC content, lowered the PE content, but had no effect on the sphingomyelin content.	Phosphatidylcholines	88-90	phosphatidylethanolamine N-methyltransferase	Sus scrofa	60-64
21958070-6	2011	Consequently, PEMT expression led to reductions in PE/PC and sphingomyelin/PC ratios.	Phosphatidylcholines	54-56	phosphatidylethanolamine N-methyltransferase	Sus scrofa	14-18
21958070-6	2011	Consequently, PEMT expression led to reductions in PE/PC and sphingomyelin/PC ratios.	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Sus scrofa	14-18
21855891-2	2011	The main conclusions from our experimental data indicate that phosphatidylcholine monolayers (PC), in contrast to phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), were resistant to the hydrolysis by human intestinal sPLA2.	Phosphatidylcholines	62-81	phospholipase A2 group X	Homo sapiens	228-233
21837751-6	2011	In 3-KO mouse liver, there is a potent effect of MAT1A deletion on lipid handling, decreasing mobilization of TG stores, TG secretion in VLDL and phosphatidylcholine synthesis via phosphatidylethanolamine N-methyltransferase.	Phosphatidylcholines	146-165	methionine adenosyltransferase I, alpha	Mus musculus	49-54
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	215-234	ATP binding cassette subfamily B member 11	Rattus norvegicus	181-185
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 11	Rattus norvegicus	158-179
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 11	Rattus norvegicus	181-185
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 4	Rattus norvegicus	248-278
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 4	Rattus norvegicus	280-284
21703191-1	2011	BACKGROUND &amp; AIMS: Canalicular phosphatidylcholine and cholesterol secretion requires the coordinate action of the ATP binding cassette transporters: the bile salt export pump (Bsep) for bile salts (BS) and the phosphatidylcholine translocator multidrug resistance protein 2 (Mdr2).	Phosphatidylcholines	215-234	ATP binding cassette subfamily B member 11	Rattus norvegicus	158-179
22057011-4	2011	LDs of fld1Delta and WT cells exhibited similar phospholipid profiles, whereas LDs of cds1 and ino2Delta strains had a higher (cds1) or lower (ino2Delta) percentage of phosphatidylcholine than those of WT, respectively.	Phosphatidylcholines	168-187	CDP-diacylglycerol synthase 1	Homo sapiens	86-90
22078872-3	2011	(2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity.	Phosphatidylcholines	105-124	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	46-51
22035958-0	2011	A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.	Phosphatidylcholines	20-39	sterol regulatory element binding transcription factor 1	Homo sapiens	12-19
22078872-3	2011	(2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity.	Phosphatidylcholines	126-128	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	46-51
22035958-4	2011	Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation.	Phosphatidylcholines	45-64	sterol regulatory element binding transcription factor 1	Homo sapiens	206-213
21787361-8	2011	In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence.	Phosphatidylcholines	87-106	lysophosphatidylcholine acyltransferase 2	Homo sapiens	75-81
22035958-4	2011	Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation.	Phosphatidylcholines	66-68	sterol regulatory element binding transcription factor 1	Homo sapiens	206-213
22035958-4	2011	Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation.	Phosphatidylcholines	133-135	sterol regulatory element binding transcription factor 1	Homo sapiens	206-213
22035958-6	2011	Thus, nutritional or genetic conditions limiting SAMe or PC production may activate SREBP-1, contributing to human metabolic disorders.	Phosphatidylcholines	57-59	sterol regulatory element binding transcription factor 1	Homo sapiens	84-91
21787361-8	2011	In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence.	Phosphatidylcholines	87-106	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	186-223
21787361-8	2011	In differentiated Caco-2/TC7 enterocytes, we identified for the first time LPCAT2 (lysophosphatidylcholine acyltransferase 2), involved in PC (phosphatidylcholine) synthesis, and 3BHS1 (3-beta-hydroxysteroid dehydrogenase 1), involved in steroid metabolism, and confirmed their partial CLD localization by immunofluorescence.	Phosphatidylcholines	87-106	lipase maturation factor 1	Mus musculus	286-289
21820390-2	2011	ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts.	Phosphatidylcholines	12-31	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-5
21820390-4	2011	Abcb4(-/-) mice lack biliary secretion of phosphatidylcholine, whereas Atp8b1-deficient mice have increased excretion of phosphatidylserine into bile.	Phosphatidylcholines	42-61	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-5
21820390-11	2011	This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine.	Phosphatidylcholines	162-181	transmembrane protein 30A	Mus musculus	78-84
21820390-11	2011	This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine.	Phosphatidylcholines	162-181	ATPase, class I, type 8B, member 1	Mus musculus	71-77
21820390-11	2011	This is most likely because the phosphatidylserine flippase complex of ATP8B1-CDC50A counteracts the destabilization of the membrane that occurs when ABCB4 flops phosphatidylcholine.	Phosphatidylcholines	162-181	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	150-155
21880860-4	2011	The homogenates of COS-7 cells overexpressing recombinant A-C1s from human, mouse, and rat showed a phospholipase A1/2 (PLA1/2) activity toward phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase A2 group IB	Rattus norvegicus	100-118
21846716-0	2011	Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis.	Phosphatidylcholines	101-120	ATP binding cassette subfamily A member 1	Homo sapiens	42-47
21846716-1	2011	Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation.	Phosphatidylcholines	51-70	ATP binding cassette subfamily A member 1	Homo sapiens	34-39
21880860-4	2011	The homogenates of COS-7 cells overexpressing recombinant A-C1s from human, mouse, and rat showed a phospholipase A1/2 (PLA1/2) activity toward phosphatidylcholine (PC).	Phosphatidylcholines	144-163	lipase H	Homo sapiens	120-124
21846716-1	2011	Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation.	Phosphatidylcholines	51-70	apolipoprotein A1	Homo sapiens	148-154
21948389-1	2011	The kinetics of lecithin:cholesterol acyltransferase(LCAT, EC 2.3.1.43)-catalyzed generation of cholesteryl ester in discoidal high density lipoproteins (HDL) was analyzed in terms of initial binding of LCAT to the disc surface followed by a three-state reaction of the hydrolysis of phosphatidylcholine sn-2 ester bond and acyl-enzyme formation.	Phosphatidylcholines	284-303	lecithin-cholesterol acyltransferase	Homo sapiens	16-52
21846716-1	2011	Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation.	Phosphatidylcholines	51-70	apolipoprotein A1	Homo sapiens	183-189
21846716-3	2011	Interestingly, phosphatidylcholine (PtdCho) was selectively removed from nonraft domains by apoA-I, whereas sphingomyelin and cholesterol were desorbed from both detergent-resistant membranes and nonraft domains.	Phosphatidylcholines	15-34	apolipoprotein A1	Homo sapiens	92-98
21846716-3	2011	Interestingly, phosphatidylcholine (PtdCho) was selectively removed from nonraft domains by apoA-I, whereas sphingomyelin and cholesterol were desorbed from both detergent-resistant membranes and nonraft domains.	Phosphatidylcholines	36-42	apolipoprotein A1	Homo sapiens	92-98
21846716-7	2011	Finally, we obtained evidence that apoA-I interaction with ABCA1 promoted the activation and gene expression of key enzymes in the PtdCho biosynthesis pathway.	Phosphatidylcholines	131-137	apolipoprotein A1	Homo sapiens	35-41
21846716-7	2011	Finally, we obtained evidence that apoA-I interaction with ABCA1 promoted the activation and gene expression of key enzymes in the PtdCho biosynthesis pathway.	Phosphatidylcholines	131-137	ATP binding cassette subfamily A member 1	Homo sapiens	59-64
21984187-2	2011	At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-51
21984187-2	2011	At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA).	Phosphatidylcholines	105-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-51
21948389-1	2011	The kinetics of lecithin:cholesterol acyltransferase(LCAT, EC 2.3.1.43)-catalyzed generation of cholesteryl ester in discoidal high density lipoproteins (HDL) was analyzed in terms of initial binding of LCAT to the disc surface followed by a three-state reaction of the hydrolysis of phosphatidylcholine sn-2 ester bond and acyl-enzyme formation.	Phosphatidylcholines	284-303	lecithin-cholesterol acyltransferase	Homo sapiens	53-57
21900497-9	2011	SAM is used as a methyl donor in three Opi1p-regulated reactions to create the abundant membrane phospholipid, phosphatidylcholine.	Phosphatidylcholines	111-130	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	39-44
21902184-3	2011	Recombinant TF was relipidated in liposomes of phosphatidylserine/phosphatidylcholine/biotin-linked phosphatidylethanolamine (20:79:1 PS/PC/bPE molar ratio).	Phosphatidylcholines	66-85	coagulation factor III, tissue factor	Homo sapiens	12-14
21937953-9	2011	Phosphatidylcholine pretreatment reduced the plasma TNF-alpha and hippocampal NOx changes and prevented the decreased neurogenesis.	Phosphatidylcholines	0-19	tumor necrosis factor	Rattus norvegicus	52-61
21937953-11	2011	Phosphatidylcholine supplementation did not reduce the overall extent of peripheral inflammatory activation, but efficiently counteracted the disturbed hippocampal neurogenesis by lowering circulating TNF-alpha concentrations.	Phosphatidylcholines	0-19	tumor necrosis factor	Rattus norvegicus	201-210
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	82-102	phospholipase A2 group IB	Homo sapiens	168-186
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	82-102	phospholipase A2 group IB	Homo sapiens	189-195
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	4-6	phospholipase A2 group IB	Homo sapiens	168-186
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	4-6	phospholipase A2 group IB	Homo sapiens	189-195
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	104-106	phospholipase A2 group IB	Homo sapiens	168-186
21575006-2	2011	LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2)  (PLA(2) ).	Phosphatidylcholines	104-106	phospholipase A2 group IB	Homo sapiens	189-195
22102037-1	2011	Sec14 is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the yeast Saccharomyces cerevisiae and is the founding member of the Sec14 protein superfamily.	Phosphatidylcholines	49-68	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
21982710-0	2011	Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	0-19	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	97-136
21982710-5	2011	The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces.	Phosphatidylcholines	24-26	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	185-224
21982710-5	2011	The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces.	Phosphatidylcholines	24-26	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	226-229
22102037-1	2011	Sec14 is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the yeast Saccharomyces cerevisiae and is the founding member of the Sec14 protein superfamily.	Phosphatidylcholines	49-68	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	167-172
22076776-6	2011	Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor).	Phosphatidylcholines	241-260	mitogen-activated protein kinase 3	Homo sapiens	13-20
22076776-6	2011	Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor).	Phosphatidylcholines	241-260	mitogen-activated protein kinase 1	Homo sapiens	25-28
22076776-6	2011	Acid-induced ERK 1/2 and p38 MAPK activation was inhibited by pertussis toxin (PTX-sensitive G(i/o) protein inhibitor), DEDA (phospholipase (PL) A(2) inhibitor), rhoCMB (PLD inhibitor), GF109203X (protein kinase C (PKC) inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor).	Phosphatidylcholines	241-260	mitogen-activated protein kinase 3	Homo sapiens	29-33
21801087-1	2011	INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile.	Phosphatidylcholines	224-243	ATP binding cassette subfamily B member 4	Homo sapiens	14-36
21722629-5	2011	We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM.	Phosphatidylcholines	145-164	interleukin 3	Mus musculus	82-95
21722629-5	2011	We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM.	Phosphatidylcholines	145-164	interleukin 3	Mus musculus	97-101
21722629-5	2011	We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM.	Phosphatidylcholines	166-168	interleukin 3	Mus musculus	82-95
21722629-5	2011	We found that the increase in proliferation rate driven by high concentrations of interleukin-3 (IL-3) is associated with a decrease in membrane phosphatidylcholine (PC) 18:0/20:4 and sphingomyelin (SM) together with an increase in PC 18:0/18:2 and dihydro SM.	Phosphatidylcholines	166-168	interleukin 3	Mus musculus	97-101
21736954-0	2011	Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in axonal phosphatidylcholine synthesis and branching of neurons.	Phosphatidylcholines	71-90	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	15-54
21736954-0	2011	Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in axonal phosphatidylcholine synthesis and branching of neurons.	Phosphatidylcholines	71-90	hemoglobin, beta adult minor chain	Mus musculus	55-60
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	14-33	cut-like homeobox 1	Mus musculus	61-64
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	14-33	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	145-184
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	14-33	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	191-198
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	35-37	cut-like homeobox 1	Mus musculus	61-64
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	35-37	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	145-184
21736954-1	2011	In the brain, phosphatidylcholine (PC) is synthesized by the CDP-choline pathway in which the rate-limiting step is catalyzed by two isoforms of CTP:phosphocholine cytidylyltransferase (CT): CTalpha and CTbeta2.	Phosphatidylcholines	35-37	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	191-198
21801087-1	2011	INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile.	Phosphatidylcholines	224-243	ATP binding cassette subfamily B member 4	Homo sapiens	38-42
21801087-1	2011	INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile.	Phosphatidylcholines	224-243	ATP binding cassette subfamily B member 1	Homo sapiens	44-58
21801087-1	2011	INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile.	Phosphatidylcholines	224-243	ATP binding cassette subfamily B member 4	Homo sapiens	102-144
21801087-1	2011	INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile.	Phosphatidylcholines	224-243	ATP binding cassette subfamily B member 4	Homo sapiens	146-151
21649806-0	2011	Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1.	Phosphatidylcholines	19-38	bile acid-transporting ATPase YBT1	Saccharomyces cerevisiae S288C	85-89
21682565-4	2011	METHODS: LOX1-targeted rho-kinase inhibitor fasudil-containing liposomes, composed of hydrogenated soy phosphatidylcholine/cholesterol/PEG(2000)-DSPE, were prepared by conjugating anti-LOX1 antibodies on the surface and by remote loading of fasudil.	Phosphatidylcholines	103-122	oxidized low density lipoprotein receptor 1	Rattus norvegicus	9-13
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Phosphatidylcholines	119-138	protein kinase C alpha	Homo sapiens	35-56
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Phosphatidylcholines	119-138	protein kinase C alpha	Homo sapiens	58-66
21600318-1	2011	GuHCl-induced denaturation of human plasma apoA-I, apoA-II, apoA-IV, apoE3 and three recombinant apoE isoforms in solution and discoidal complexes with phosphatidylcholine (only plasma proteins) was studied.	Phosphatidylcholines	152-171	apolipoprotein A1	Homo sapiens	43-49
21649806-4	2011	Four ABC transporter proteins are found on the limiting membrane of the yeast vacuole and loss of one of these vacuolar ABC transporters, Ybt1, caused a major defect in the normal delivery of the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) to the lumen of the vacuole.	Phosphatidylcholines	196-215	bile acid-transporting ATPase YBT1	Saccharomyces cerevisiae S288C	138-142
21649806-4	2011	Four ABC transporter proteins are found on the limiting membrane of the yeast vacuole and loss of one of these vacuolar ABC transporters, Ybt1, caused a major defect in the normal delivery of the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) to the lumen of the vacuole.	Phosphatidylcholines	217-219	bile acid-transporting ATPase YBT1	Saccharomyces cerevisiae S288C	138-142
21721951-7	2011	ADRP-LDs concomitantly stimulate saturated phosphatidylcholine (satPC) synthesis by A549 cells, which is inhibited by ADRP antibody, indicating that this is a receptor-mediated mechanism.	Phosphatidylcholines	43-62	perilipin 2	Rattus norvegicus	0-4
21683785-2	2011	Anaphylatoxin C3a also binds and breaks bacterial lipid membranes and phosphatidylcholine liposomes.	Phosphatidylcholines	70-89	complement C3	Homo sapiens	14-17
21688815-0	2011	Bovine insulin-phosphatidylcholine mixed Langmuir monolayers: behavior at the air-water interface.	Phosphatidylcholines	15-34	insulin	Bos taurus	7-14
21688815-4	2011	Our results indicate that intermolecular interactions between INS and PC depend on both the monolayer state and the structural characteristics of INS at the interface, which are strongly influenced by the subphase pH and salt content.	Phosphatidylcholines	70-72	insulin	Bos taurus	62-65
21688815-4	2011	Our results indicate that intermolecular interactions between INS and PC depend on both the monolayer state and the structural characteristics of INS at the interface, which are strongly influenced by the subphase pH and salt content.	Phosphatidylcholines	70-72	insulin	Bos taurus	146-149
21721951-7	2011	ADRP-LDs concomitantly stimulate saturated phosphatidylcholine (satPC) synthesis by A549 cells, which is inhibited by ADRP antibody, indicating that this is a receptor-mediated mechanism.	Phosphatidylcholines	43-62	perilipin 2	Rattus norvegicus	118-122
21549185-2	2011	The primary structure of the peptide that we predicted coincided completely with the amino acid sequence of the later identified sphingomyelin synthase 1 protein (SMS1), which catalyses the transfer of a phosphorylcholine moiety from phosphatidylcholine to ceramide, producing sphingomyelin and diacylglycerol (Huitema et al., 2004; Yamaoka et al., 2004).	Phosphatidylcholines	234-253	sphingomyelin synthase 1	Homo sapiens	129-161
21511545-2	2011	Phospholipase A(2) (PLA(2)) quantitation in real-time, using (7-nitro-2-1,3-benzoxadiazol-4-yl)amino-derivatives of phosphatidylcholine (NBD-PCs) as substrates, is influenced by high protein content, color or turbidity.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Homo sapiens	0-18
21549185-2	2011	The primary structure of the peptide that we predicted coincided completely with the amino acid sequence of the later identified sphingomyelin synthase 1 protein (SMS1), which catalyses the transfer of a phosphorylcholine moiety from phosphatidylcholine to ceramide, producing sphingomyelin and diacylglycerol (Huitema et al., 2004; Yamaoka et al., 2004).	Phosphatidylcholines	234-253	sphingomyelin synthase 1	Homo sapiens	163-167
21423211-2	2011	The product of choline kinase-alpha, phosphocholine, serves as an essential metabolic reservoir for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the production of lipid second messengers.	Phosphatidylcholines	118-137	choline kinase alpha	Homo sapiens	15-35
21525137-0	2011	The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress.	Phosphatidylcholines	4-23	phospholipase C1	Arabidopsis thaliana	36-51
21525137-0	2011	The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress.	Phosphatidylcholines	4-23	non-specific phospholipase C4	Arabidopsis thaliana	52-56
21525137-1	2011	Phosphatidylcholine-hydrolysing phospholipase C, also known as non-specific phospholipase C (NPC), is a new member of the plant phospholipase family that reacts to environmental stresses such as phosphate deficiency and aluminium toxicity, and has a role in root development and brassinolide signalling.	Phosphatidylcholines	0-19	phospholipase C1	Arabidopsis thaliana	32-47
21525137-1	2011	Phosphatidylcholine-hydrolysing phospholipase C, also known as non-specific phospholipase C (NPC), is a new member of the plant phospholipase family that reacts to environmental stresses such as phosphate deficiency and aluminium toxicity, and has a role in root development and brassinolide signalling.	Phosphatidylcholines	0-19	phospholipase C1	Arabidopsis thaliana	76-91
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	146-165	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	146-165	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-55
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	167-169	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	167-169	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-55
21386858-7	2011	Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P&lt;0.05) but negatively with leptin (r=-0.252, P&lt;0.05), insulin (r=-0.335, P&lt;0.01) and insulin resistance (r=-0.322, P&lt;0.01).	Phosphatidylcholines	19-38	adiponectin, C1Q and collagen domain containing	Homo sapiens	87-98
21386858-7	2011	Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P&lt;0.05) but negatively with leptin (r=-0.252, P&lt;0.05), insulin (r=-0.335, P&lt;0.01) and insulin resistance (r=-0.322, P&lt;0.01).	Phosphatidylcholines	19-38	leptin	Homo sapiens	140-146
21386858-7	2011	Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P&lt;0.05) but negatively with leptin (r=-0.252, P&lt;0.05), insulin (r=-0.335, P&lt;0.01) and insulin resistance (r=-0.322, P&lt;0.01).	Phosphatidylcholines	19-38	insulin	Homo sapiens	170-177
21386858-7	2011	Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r=0.290, P&lt;0.05) but negatively with leptin (r=-0.252, P&lt;0.05), insulin (r=-0.335, P&lt;0.01) and insulin resistance (r=-0.322, P&lt;0.01).	Phosphatidylcholines	19-38	insulin	Homo sapiens	204-211
21413027-3	2011	Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs.	Phosphatidylcholines	34-53	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21413027-3	2011	Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs.	Phosphatidylcholines	34-53	C-C motif chemokine ligand 2	Homo sapiens	112-117
21511545-2	2011	Phospholipase A(2) (PLA(2)) quantitation in real-time, using (7-nitro-2-1,3-benzoxadiazol-4-yl)amino-derivatives of phosphatidylcholine (NBD-PCs) as substrates, is influenced by high protein content, color or turbidity.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Homo sapiens	20-26
21312053-0	2011	Oxidized phosphatidylcholine induces migration of bone marrow-derived mesenchymal stem cells through Kruppel-like factor 4-dependent mechanism.	Phosphatidylcholines	9-28	Kruppel like factor 4	Homo sapiens	101-122
21614002-3	2011	Here we show that an unusual phosphatidylcholine species with two saturated 12 carbon fatty acid acyl side chains (dilauroyl phosphatidylcholine (DLPC)) is an LRH-1 agonist ligand in vitro.	Phosphatidylcholines	29-48	nuclear receptor subfamily 5, group A, member 2	Mus musculus	159-164
21638239-1	2011	The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 4	Homo sapiens	25-29
21638239-1	2011	The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile.	Phosphatidylcholines	145-164	ATP binding cassette subfamily B member 4	Homo sapiens	44-49
21454645-1	2011	The exposure of the plasma membrane calcium pump (PMCA) to the surrounding phospholipids was assessed by measuring the incorporation of the photoactivatable phosphatidylcholine analog [(125)I]TID-PC/16 to the protein.	Phosphatidylcholines	157-176	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	20-48
21454645-1	2011	The exposure of the plasma membrane calcium pump (PMCA) to the surrounding phospholipids was assessed by measuring the incorporation of the photoactivatable phosphatidylcholine analog [(125)I]TID-PC/16 to the protein.	Phosphatidylcholines	157-176	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	50-54
21614002-7	2011	These findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis.	Phosphatidylcholines	43-62	nuclear receptor subfamily 5, group A, member 2	Mus musculus	27-32
21454708-6	2011	Activity and protein of PE N-methyltransferase (PEMT), which produces PC by methylation of PE, are absent in 3T3-L1 fibroblasts but were induced at day 5.	Phosphatidylcholines	70-72	phosphatidylethanolamine N-methyltransferase	Mus musculus	24-46
21454708-6	2011	Activity and protein of PE N-methyltransferase (PEMT), which produces PC by methylation of PE, are absent in 3T3-L1 fibroblasts but were induced at day 5.	Phosphatidylcholines	70-72	phosphatidylethanolamine N-methyltransferase	Mus musculus	48-52
21521793-5	2011	We investigated possible participation of each of the three arms of the UPR and found that only the activating transcription factor 6 (ATF6) arm was selectively activated after induction of GFP-b(5)tail expression; peak ATF6alpha activation preceded the increase in phosphatidylcholine synthesis.	Phosphatidylcholines	266-285	activating transcription factor 6	Homo sapiens	100-133
21521793-5	2011	We investigated possible participation of each of the three arms of the UPR and found that only the activating transcription factor 6 (ATF6) arm was selectively activated after induction of GFP-b(5)tail expression; peak ATF6alpha activation preceded the increase in phosphatidylcholine synthesis.	Phosphatidylcholines	266-285	activating transcription factor 6	Homo sapiens	135-139
21389045-8	2011	Thus, both SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions.	Phosphatidylcholines	83-85	putative S-adenosylmethionine synthase 1	Caenorhabditis elegans	11-17
21411618-0	2011	Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.	Phosphatidylcholines	31-50	phosphatidylethanolamine N-methyltransferase	Homo sapiens	89-133
21411618-3	2011	Previously, we showed that mice that lack functional PEMT have dramatically reduced concentrations of docosahexaenoic acid (DHA; 22:6n-3) in plasma and of liver phosphatidylcholine (PtdCho)-a phospholipid formed by PEMT.	Phosphatidylcholines	161-180	phosphatidylethanolamine N-methyltransferase	Mus musculus	53-57
21411618-3	2011	Previously, we showed that mice that lack functional PEMT have dramatically reduced concentrations of docosahexaenoic acid (DHA; 22:6n-3) in plasma and of liver phosphatidylcholine (PtdCho)-a phospholipid formed by PEMT.	Phosphatidylcholines	182-188	phosphatidylethanolamine N-methyltransferase	Mus musculus	53-57
21411618-4	2011	OBJECTIVE: The objective was to evaluate plasma PtdCho-DHA concentrations as a noninvasive marker of liver PEMT activity in humans.	Phosphatidylcholines	48-54	phosphatidylethanolamine N-methyltransferase	Homo sapiens	107-111
21290121-2	2011	Here the effect of the peptide hormone angiotensin II (Ang II), an agonist of the angiotensin receptors, on the structure of unilamellar and multilamellar dimyristoyl phosphatidylcholine vesicles was studied by small angle neutron scattering, dynamic light scattering and differential scanning calorimetry.	Phosphatidylcholines	167-186	angiotensinogen	Homo sapiens	39-53
21290121-2	2011	Here the effect of the peptide hormone angiotensin II (Ang II), an agonist of the angiotensin receptors, on the structure of unilamellar and multilamellar dimyristoyl phosphatidylcholine vesicles was studied by small angle neutron scattering, dynamic light scattering and differential scanning calorimetry.	Phosphatidylcholines	167-186	angiotensinogen	Homo sapiens	55-61
21389045-8	2011	Thus, both SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions.	Phosphatidylcholines	83-85	Phosphoethanolamine N-methyltransferase 1	Caenorhabditis elegans	22-27
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylcholines	49-51	prolactin induced protein	Homo sapiens	20-23
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylcholines	49-51	secretoglobin family 2B member 3, pseudogene	Homo sapiens	152-155
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylcholines	49-51	secretoglobin family 2B member 3, pseudogene	Homo sapiens	193-196
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Phosphatidylcholines	31-50	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	0-4
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Phosphatidylcholines	31-50	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	5-9
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Phosphatidylcholines	31-50	ATP binding cassette subfamily G member 5	Mus musculus	14-19
21118090-5	2011	MDR3/Mdr2 and ABCG5/G8 secrete phosphatidylcholine and cholesterol, respectively, in coordination with BSEP-mediated bile acid secretion to mask the detergent/toxic effects of bile acids in the bile ductular space.	Phosphatidylcholines	31-50	ATP-binding cassette, sub-family B (MDR/TAP), member 11	Mus musculus	103-107
20937607-2	2011	The signaling of these receptors change phosphatidylcholine-specific phospholipase C (PC-PLC) activity, but there have been no reported PC-PLC studies in migraine.	Phosphatidylcholines	40-59	heparan sulfate proteoglycan 2	Homo sapiens	89-92
21273556-0	2011	Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice.	Phosphatidylcholines	9-28	apolipoprotein E	Mus musculus	112-116
21085975-3	2011	Complex of curcumin with phosphatidyl choline (PC) was prepared and characterized on the basis of TLC, DSC, melting point and IR spectroscopic analysis.	Phosphatidylcholines	25-45	declival sulcus of cerebellum	Mus musculus	103-106
21085975-3	2011	Complex of curcumin with phosphatidyl choline (PC) was prepared and characterized on the basis of TLC, DSC, melting point and IR spectroscopic analysis.	Phosphatidylcholines	47-49	declival sulcus of cerebellum	Mus musculus	103-106
21266973-12	2011	CONCLUSIONS: The transition to tumourigenesis in prostate epithelial cell lines results in major changes to Cho metabolite release into the medium and PKC signalling to phosphatidylcholine turnover.	Phosphatidylcholines	169-188	protein kinase C alpha	Homo sapiens	151-154
21149645-4	2011	Phosphatidylcholines (PCs) composing saturated and monounsaturated fatty acids (PC 32:0, PC 32:1, and PC 34:1) were detected mainly in the outer and inner plexiform layers (OPL and IPL), whereas PCs containing polyunsaturated fatty acids (PC 36:4, PC 38:6, and PC 40:6) composed the inner segment (IS) and outer segment (OS).	Phosphatidylcholines	0-20	pleckstrin homology like domain family A member 2	Homo sapiens	181-184
21149645-4	2011	Phosphatidylcholines (PCs) composing saturated and monounsaturated fatty acids (PC 32:0, PC 32:1, and PC 34:1) were detected mainly in the outer and inner plexiform layers (OPL and IPL), whereas PCs containing polyunsaturated fatty acids (PC 36:4, PC 38:6, and PC 40:6) composed the inner segment (IS) and outer segment (OS).	Phosphatidylcholines	22-25	pleckstrin homology like domain family A member 2	Homo sapiens	181-184
21149645-5	2011	The presence of PCs containing polyunsaturated fatty acids in the OS layer implied that these phospholipids form flexible lipid bilayers, which facilitate phototransduction process occurring in the rhodopsin rich OS layer.	Phosphatidylcholines	16-19	rhodopsin	Homo sapiens	198-207
21270363-5	2011	More than one-half of premenopausal women may be resistant to choline deficiency-induced organ dysfunction, because estrogen induces the gene [phosphatidylethanolamine-N-methyltransferase (PEMT)] that catalyzes endogenous synthesis of phosphatidylcholine, which can subsequently yield choline.	Phosphatidylcholines	235-254	phosphatidylethanolamine N-methyltransferase	Homo sapiens	143-187
21270363-5	2011	More than one-half of premenopausal women may be resistant to choline deficiency-induced organ dysfunction, because estrogen induces the gene [phosphatidylethanolamine-N-methyltransferase (PEMT)] that catalyzes endogenous synthesis of phosphatidylcholine, which can subsequently yield choline.	Phosphatidylcholines	235-254	phosphatidylethanolamine N-methyltransferase	Homo sapiens	189-193
21291330-1	2011	BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids.	Phosphatidylcholines	119-139	phospholipase A2 group VII	Homo sapiens	12-51
21291330-1	2011	BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids.	Phosphatidylcholines	119-139	phospholipase A2 group VII	Homo sapiens	53-60
21177434-2	2011	Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils.	Phosphatidylcholines	156-175	arachidonate 5-lipoxygenase	Homo sapiens	13-18
21080035-6	2011	Binding of prothrombin to a surface containing 20% phosphatidylserine/80% phosphatidylcholine was detected by surface plasmon resonance, whereas no interaction with gla-domainless prothrombin was observed.	Phosphatidylcholines	74-93	coagulation factor II, thrombin	Homo sapiens	11-22
21210202-0	2011	Phosphatidylcholine-rich nanoliposomes: potential tools for serum C-reactive protein reduction?	Phosphatidylcholines	0-19	C-reactive protein	Homo sapiens	66-84
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-19	cut-like homeobox 1	Rattus norvegicus	79-82
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	245-289
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	291-295
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	21-23	cut-like homeobox 1	Rattus norvegicus	79-82
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	245-289
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	291-295
21068006-1	2011	Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	203-205	cut-like homeobox 1	Rattus norvegicus	79-82
22022488-6	2011	The affinity of PDC-109 for phosphatidylcholine increased at higher pH, which is physiologically relevant in view of the basic nature of the seminal plasma.	Phosphatidylcholines	28-47	seminal plasma protein PDC-109	Bos taurus	16-23
21315271-2	2011	[(18)F]FECH is actively transported into mammalian cells, becomes phosphorylated by choline kinase and gets incorporated into the cell membrane after being metabolized to phosphatidylcholine.	Phosphatidylcholines	171-190	ferrochelatase	Homo sapiens	7-11
21173026-7	2011	Analysis of HFA-triacylglycerol molecular species and regiochemistry, along with analysis of the HFA content of phosphatidylcholine, indicates that RcPDAT1A functions as a PDAT in vivo.	Phosphatidylcholines	112-131	phospholipid:diacylglycerol acyltransferase	Arabidopsis thaliana	150-154
21415529-3	2011	When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL&gt;PS&gt;PE&gt;PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids.	Phosphatidylcholines	57-76	microsomal glutathione S-transferase 1	Homo sapiens	5-10
21415529-3	2011	When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL&gt;PS&gt;PE&gt;PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids.	Phosphatidylcholines	78-80	microsomal glutathione S-transferase 1	Homo sapiens	5-10
21415529-3	2011	When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL&gt;PS&gt;PE&gt;PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids.	Phosphatidylcholines	103-105	microsomal glutathione S-transferase 1	Homo sapiens	5-10
20601268-2	2011	After a 24-hour reaction of phosphatidylcholine (PC) and tyrosol with PLD, a new product was detected by TLC and identified to phosphatidyl-tyrosol by high-resolution MS and NMR analyses.	Phosphatidylcholines	28-47	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
20732453-10	2010	This data indicated that during the interaction between human HDL and phosphatidylcholine liposome apo A-II participates both in structural modification of liposomes and in the generation of pre-beta mobility fraction of constant content of PL, apo A-I and apo A-II.	Phosphatidylcholines	70-89	apolipoprotein A2	Homo sapiens	99-107
21738695-0	2011	Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of betaI-spectrin.	Phosphatidylcholines	70-89	spectrin beta, erythrocytic	Homo sapiens	112-126
20974857-4	2010	Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	125-144	phospholipase A2 group X	Homo sapiens	10-19
21126034-1	2010	Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively).	Phosphatidylcholines	233-252	lysozyme	Homo sapiens	173-181
21126034-1	2010	Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively).	Phosphatidylcholines	233-252	lysozyme	Homo sapiens	183-185
21126034-1	2010	Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively).	Phosphatidylcholines	254-256	lysozyme	Homo sapiens	173-181
21126034-1	2010	Intermolecular time-resolved and single-molecule Forster resonance energy transfer (FRET) have been applied to detect quantitatively the aggregation of polycationic protein lysozyme (Lz) in the presence of lipid vesicles composed of phosphatidylcholine (PC) and its mixture with 5, 10, 20, or 40 mol % of phosphatidylglycerol (PG) (PG5, PG10, PG20, or PG40, respectively).	Phosphatidylcholines	254-256	lysozyme	Homo sapiens	183-185
21126034-2	2010	Upon binding to PC, PG5, or PG10 model membranes, Lz was found to retain its native monomeric conformation, while increasing content of anionic lipid up to 20 or 40 mol % resulted in the formation of Lz aggregates.	Phosphatidylcholines	16-18	lysozyme	Homo sapiens	50-52
24061892-1	2010	Secreted group X phospholipase A2 (sPLA2-X) is one of the most effective mammalian PLA2 enzymes at hydrolyzing plasma lipoproteins and phospholipids in the membranes of intact cells, due in particular to its relatively high binding affinity to zwitterionic phospholipid substrates, such as phosphatidylcholine.	Phosphatidylcholines	290-309	phospholipase A2 group X	Homo sapiens	35-42
24061892-1	2010	Secreted group X phospholipase A2 (sPLA2-X) is one of the most effective mammalian PLA2 enzymes at hydrolyzing plasma lipoproteins and phospholipids in the membranes of intact cells, due in particular to its relatively high binding affinity to zwitterionic phospholipid substrates, such as phosphatidylcholine.	Phosphatidylcholines	290-309	phospholipase A2 group IIA	Homo sapiens	36-40
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	101-105
21074554-1	2011	A phospholipase A2 was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol.	Phosphatidylcholines	122-141	phospholipase A2 group IB	Canis lupus familiaris	2-18
21094990-3	2011	PLA(2) activity in TEU-2 cells was measured using (16:0, [(3)H]18:1) plasmenylcholine and phosphatidylcholine substrates in the presence and absence of calcium.	Phosphatidylcholines	90-109	phospholipase A2 group IB	Homo sapiens	0-6
21156133-4	2010	We used optical tweezers to measure the strength and attachment lifetime of single myo1c molecules as they bind beads coated with a bilayer of 2% phosphatidylinositol 4,5-bisphosphate and 98% phosphatidylcholine.	Phosphatidylcholines	192-211	myosin IC	Homo sapiens	83-88
20732453-10	2010	This data indicated that during the interaction between human HDL and phosphatidylcholine liposome apo A-II participates both in structural modification of liposomes and in the generation of pre-beta mobility fraction of constant content of PL, apo A-I and apo A-II.	Phosphatidylcholines	70-89	apolipoprotein A1	Homo sapiens	245-265
20861172-2	2010	Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Homo sapiens	47-91
20858845-1	2010	In a previous report, we identified the receptor for activated C-kinase 1 (RACK1) as a positive regulator of the cellular localization and expression of ATP-binding cassette B4, a phosphatidylcholine translocator expressed on the bile canalicular membrane.	Phosphatidylcholines	180-199	receptor for activated C kinase 1	Homo sapiens	40-73
20858845-1	2010	In a previous report, we identified the receptor for activated C-kinase 1 (RACK1) as a positive regulator of the cellular localization and expression of ATP-binding cassette B4, a phosphatidylcholine translocator expressed on the bile canalicular membrane.	Phosphatidylcholines	180-199	receptor for activated C kinase 1	Homo sapiens	75-80
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	107-129
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	75-77	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	101-105
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	107-129
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20860552-1	2010	The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT).	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Homo sapiens	156-160
20861172-2	2010	Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Homo sapiens	93-97
20925360-5	2010	Possible lipid binding sites on the surface of Osh4 were identified by docking four lipid moieties modeled from different lipid head groups (phosphatidylcholine, phosphatidylserine, phosphatidylinositol(4,5)biphosphate, and phosphatidylinositol(3,4,5)triphosphate).	Phosphatidylcholines	141-160	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	47-51
21117173-5	2010	AFM results are consistent with the above findings and show that addition of PDC-109 leads to a complete breakdown of PC membranes.	Phosphatidylcholines	118-120	seminal plasma protein PDC-109	Bos taurus	77-84
21117173-2	2010	Additionally, the effect of cholesterol on the binding of PDC-109 to phosphatidylcholine (PC) membranes was studied.	Phosphatidylcholines	69-88	seminal plasma protein PDC-109	Bos taurus	58-65
21117173-2	2010	Additionally, the effect of cholesterol on the binding of PDC-109 to phosphatidylcholine (PC) membranes was studied.	Phosphatidylcholines	90-92	seminal plasma protein PDC-109	Bos taurus	58-65
20620034-1	2010	Total internal reflection fluorescence microscopy (TIRFM) has been utilized to explore the effect of cationic protein lysozyme (Lz) on the morphology of solid-supported lipid bilayers (SLBs) comprised of zwitterionic lipid phosphatidylcholine (PC) and its mixture with anionic lipid cardiolipin (CL).	Phosphatidylcholines	223-242	lysozyme	Homo sapiens	128-130
20853818-6	2010	The donor chain length limit of C10 coincides with the phosphatidylcholine transition from displaying bilayer to micellar properties in water, but the detergent inhibitor lauryldimethylamine N-oxide also gradually became ineffective in a micellar assay as the selected acyl chains were shortened to C10.	Phosphatidylcholines	55-74	chromosome 12 open reading frame 57	Homo sapiens	32-35
20620034-1	2010	Total internal reflection fluorescence microscopy (TIRFM) has been utilized to explore the effect of cationic protein lysozyme (Lz) on the morphology of solid-supported lipid bilayers (SLBs) comprised of zwitterionic lipid phosphatidylcholine (PC) and its mixture with anionic lipid cardiolipin (CL).	Phosphatidylcholines	244-246	lysozyme	Homo sapiens	128-130
20642808-3	2010	Cytosolic phospholipase A2 (cPLA(2) ) is an enzyme that is responsible for the hydrolysis of membrane phospholipids such as phosphatidylcholine.	Phosphatidylcholines	124-143	phospholipase A2 group IVA	Homo sapiens	0-35
20642808-4	2010	Following activation, cPLA(2) cleaves phosphatidylcholine to yield free fatty acid and lysophosphatidylcholine.	Phosphatidylcholines	38-57	phospholipase A2 group IVA	Homo sapiens	22-29
20570648-5	2010	Here we investigate the structure and aggregation properties of hIAPP(1-19) in relation to membrane damage in vitro by using membranes of the zwitterionic lipid phosphatidylcholine (PC), the anionic lipid phosphatidylserine (PS) and mixtures of these lipids to mimic membranes of islet cells.	Phosphatidylcholines	161-180	islet amyloid polypeptide	Homo sapiens	64-69
20858419-1	2010	Resonance energy transfer (RET) from anthrylvinyl-labeled phosphatidylcholine (AV-PC) or cardiolipin (AV-CL) to cytochrome c (cyt c) heme moiety was employed to assess the molecular-level details of protein interactions with lipid bilayers composed of PC with 2.5 (CL2.5), 5 (CL5), 10 (CL10), or 20 (CL20) mol % CL under conditions of varying ionic strength and lipid/protein molar ratio.	Phosphatidylcholines	58-77	cytochrome c, somatic	Homo sapiens	112-124
20858419-1	2010	Resonance energy transfer (RET) from anthrylvinyl-labeled phosphatidylcholine (AV-PC) or cardiolipin (AV-CL) to cytochrome c (cyt c) heme moiety was employed to assess the molecular-level details of protein interactions with lipid bilayers composed of PC with 2.5 (CL2.5), 5 (CL5), 10 (CL10), or 20 (CL20) mol % CL under conditions of varying ionic strength and lipid/protein molar ratio.	Phosphatidylcholines	58-77	cytochrome c, somatic	Homo sapiens	126-131
20735042-1	2010	Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
20735042-1	2010	Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
20628054-2	2010	Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	164-183	lecithin retinol acyltransferase	Homo sapiens	0-32
20628054-2	2010	Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	164-183	lecithin retinol acyltransferase	Homo sapiens	34-38
20628054-4	2010	Detailed mass spectrometry analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine substrates.	Phosphatidylcholines	134-153	lecithin retinol acyltransferase	Homo sapiens	50-54
20628054-7	2010	Additionally, we examined the effect of increasing fatty acyl side chain length in phosphatidylcholine on substrate accessibility in this reaction, which provided insights into the function of the single membrane-spanning domain of LRAT.	Phosphatidylcholines	83-102	lecithin retinol acyltransferase	Homo sapiens	232-236
20153493-2	2010	In humans, ABCB4 appears to be exclusively expressed on the apical membrane of hepatocytes where it translocates phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	113-132	ATP binding cassette subfamily B member 4	Homo sapiens	11-16
20380879-1	2010	As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	92-111	patatin like phospholipase domain containing 6	Homo sapiens	22-48
20380879-1	2010	As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	92-111	patatin like phospholipase domain containing 6	Homo sapiens	50-53
20380879-1	2010	As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	113-115	patatin like phospholipase domain containing 6	Homo sapiens	22-48
20380879-1	2010	As a phospholipase B, neuropathy target esterase (NTE) is responsible for the conversion of phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	113-115	patatin like phospholipase domain containing 6	Homo sapiens	50-53
20525991-3	2010	We demonstrate that during retinoic acid (RA)-induced differentiation of Neuro-2a cells, PtdCho synthesis was promoted by an ordered and sequential activation of choline kinase alpha (CK(alpha)) and choline cytidylyltransferase alpha (CCT(alpha)).	Phosphatidylcholines	89-95	choline kinase alpha	Mus musculus	162-193
20525991-3	2010	We demonstrate that during retinoic acid (RA)-induced differentiation of Neuro-2a cells, PtdCho synthesis was promoted by an ordered and sequential activation of choline kinase alpha (CK(alpha)) and choline cytidylyltransferase alpha (CCT(alpha)).	Phosphatidylcholines	89-95	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	235-245
20651827-4	2010	Sec14 was first identified as a phosphatidylcholine (PC) - phosphatidylinositol (PI) transfer protein required for viability, with reduced Sec14 function resulting in diminished vesicular transport out of the trans-Golgi.	Phosphatidylcholines	32-51	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
20651827-4	2010	Sec14 was first identified as a phosphatidylcholine (PC) - phosphatidylinositol (PI) transfer protein required for viability, with reduced Sec14 function resulting in diminished vesicular transport out of the trans-Golgi.	Phosphatidylcholines	53-55	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
20699392-6	2010	PEAMT catalyzes the first committed step of choline synthesis in Arabidopsis and defines a variant pathway for PC synthesis not found in yeasts or mammals.	Phosphatidylcholines	111-113	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	0-5
20579106-2	2010	PLD1 preferentially hydrolyzes phosphatidylcholine to phosphatidic acid.	Phosphatidylcholines	31-50	phospholipase D	Saccharomyces cerevisiae S288C	0-4
20674552-3	2010	The present work demonstrates that the interactions between the protein BSP1 and model membranes composed with phosphatidylcholine lead to drastic changes in the morphology of the lipidic self-assemblies.	Phosphatidylcholines	111-130	seminal plasma protein PDC-109	Bos taurus	72-76
20891039-3	2010	In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to.	Phosphatidylcholines	133-152	C-reactive protein	Homo sapiens	17-20
20891039-3	2010	In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to.	Phosphatidylcholines	133-152	phospholipase A and acyltransferase 1	Homo sapiens	47-62
20891039-3	2010	In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to.	Phosphatidylcholines	133-152	C-reactive protein	Homo sapiens	235-238
20891039-6	2010	For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane.	Phosphatidylcholines	61-80	phospholipase A and acyltransferase 1	Homo sapiens	33-48
20891039-6	2010	For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane.	Phosphatidylcholines	61-80	C-reactive protein	Homo sapiens	125-128
20891039-6	2010	For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane.	Phosphatidylcholines	61-80	C-reactive protein	Homo sapiens	236-239
27713341-1	2010	Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine.	Phosphatidylcholines	74-93	phospholipase D2	Mus musculus	0-16
20452975-2	2010	Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	32-34	phosphatidylethanolamine N-methyltransferase	Mus musculus	108-152
20452975-2	2010	Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	32-34	phosphatidylethanolamine N-methyltransferase	Mus musculus	154-158
20623096-1	2010	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
20623096-1	2010	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
20489212-6	2010	Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells.	Phosphatidylcholines	4-23	lysophosphatidylcholine acyltransferase 3	Homo sapiens	43-49
20489212-6	2010	Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells.	Phosphatidylcholines	4-23	stearoyl-CoA desaturase	Homo sapiens	160-164
20598156-1	2010	BACKGROUND: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi.	Phosphatidylcholines	33-52	ATP binding cassette subfamily B member 4	Canis lupus familiaris	12-17
20598156-1	2010	BACKGROUND: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi.	Phosphatidylcholines	76-95	ATP binding cassette subfamily B member 4	Canis lupus familiaris	12-17
27713341-1	2010	Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine.	Phosphatidylcholines	74-93	phospholipase D2	Mus musculus	18-22
19684306-1	2010	CTP:phosphocholine cytidylyltransferase (CCTalpha) plays a key role in the biosynthesis of surfactant phosphatidylcholine.	Phosphatidylcholines	102-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
19684306-1	2010	CTP:phosphocholine cytidylyltransferase (CCTalpha) plays a key role in the biosynthesis of surfactant phosphatidylcholine.	Phosphatidylcholines	102-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-49
19684306-11	2010	Only overexpression of CCTalpha(1-367) increased surfactant phosphatidylcholine synthesis.	Phosphatidylcholines	60-79	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	23-31
20452604-4	2010	We selected the specific detection approach by neutral loss survey-dependent MS3, for the identification of molecular species of phosphatidylcholine, sphingomyelin and phosphatidylserine.	Phosphatidylcholines	129-148	minisatellites detected by probe MMS3	Mus musculus	77-80
20346413-0	2010	Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts.	Phosphatidylcholines	101-120	plasminogen	Homo sapiens	26-37
20346413-0	2010	Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts.	Phosphatidylcholines	101-120	lipoprotein(a)	Homo sapiens	64-81
20346413-1	2010	Human apolipoprotein(a) (apo(a)), synthesized in the liver, contains oxidized phosphatidylcholine (oxPtdPC) adducts probably generated at the hepatic site.	Phosphatidylcholines	78-97	lipoprotein(a)	Homo sapiens	6-23
20519644-4	2010	We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro.	Phosphatidylcholines	179-198	CD1b molecule	Bos taurus	73-77
20519644-4	2010	We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro.	Phosphatidylcholines	179-198	CD1b molecule	Bos taurus	88-93
20338778-1	2010	Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro.	Phosphatidylcholines	67-87	phosphatidylcholine transfer protein	Mus musculus	0-36
20338778-1	2010	Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro.	Phosphatidylcholines	67-87	phosphatidylcholine transfer protein	Mus musculus	38-43
20338778-1	2010	Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro.	Phosphatidylcholines	67-87	phosphatidylcholine transfer protein	Mus musculus	53-59
20338778-6	2010	Because PC-TP discriminates between phosphatidylcholines within lipid bilayers, it might function as a sensor that links metabolic regulation to membrane composition.	Phosphatidylcholines	36-56	phosphatidylcholine transfer protein	Mus musculus	8-13
20144678-7	2010	Much higher concentrations of sPLA(2)-IIA are required for its action on host cell membranes and surfactant both of which are mainly composed by phosphatidylcholine, a poor substrate for sPLA(2)-IIA.	Phosphatidylcholines	145-164	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	30-41
20153800-8	2010	Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis.	Phosphatidylcholines	96-115	phospholipase A2 group IIA	Homo sapiens	15-20
20153800-8	2010	Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis.	Phosphatidylcholines	96-115	phospholipase A2 group IIA	Homo sapiens	22-27
20153800-8	2010	Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of LDL, became an attractive target in atherosclerosis.	Phosphatidylcholines	96-115	phospholipase A2 group IIA	Homo sapiens	42-47
19937605-9	2010	This difference was attributed to the tenfold reduction in phosphatidylcholine concentration in the infant model limiting the protective effect of this phospholipid on beta-Lg digestion.	Phosphatidylcholines	59-78	beta-lactoglobulin	Bos taurus	168-175
20185359-6	2010	However, it is equally clear that a holistic understanding of plant lipid metabolism is still lacking, mainly owing to the continually emerging complexity and interplay between pathways, recently exemplified by the identification of the ROD1 phosphatidylcholine:diacylglycerol cholinephosphotransferase involved in the channelling of unsaturated fatty acids into storage oil.	Phosphatidylcholines	242-261	polypyrimidine tract binding protein 3	Homo sapiens	237-241
20503434-2	2010	In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively.	Phosphatidylcholines	26-28	cut like homeobox 1	Homo sapiens	144-147
20503434-2	2010	In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively.	Phosphatidylcholines	26-28	cut like homeobox 1	Homo sapiens	159-162
19940811-3	2010	We proposed that sPLA2 acted on the gastric hydrophobic barrier, composed primarily of phosphatidylcholine (PC), to degrade it and produce lyso-PC, an agent that is damaging to the mucosa.	Phosphatidylcholines	87-106	phospholipase A2 group IIA	Rattus norvegicus	17-22
20345604-8	2010	Detailed analyses of acyl lipid composition indicated that all suppressors alleviated the increase in the level of linoleic acid esterified to phosphatidylcholine (PC-18:2) in LT-treated vte2, and this alleviation significantly correlated with their extent of suppression of photoassimilate export.	Phosphatidylcholines	143-162	homogentisate phytyltransferase 1	Arabidopsis thaliana	187-191
20345632-6	2010	*On lipid and acyl-CoA analyses, the siliques, but not the leaves, of the acbp1 mutant accumulated galactolipid monogalactosyldiacylglycerol and 18:0-CoA, but the levels of most polyunsaturated species of phospholipid, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine, declined.	Phosphatidylcholines	227-246	acyl-CoA binding protein 1	Arabidopsis thaliana	74-79
19940811-3	2010	We proposed that sPLA2 acted on the gastric hydrophobic barrier, composed primarily of phosphatidylcholine (PC), to degrade it and produce lyso-PC, an agent that is damaging to the mucosa.	Phosphatidylcholines	108-110	phospholipase A2 group IIA	Rattus norvegicus	17-22
20507939-0	2010	Plant phosphatidylcholine-hydrolyzing phospholipases C NPC3 and NPC4 with roles in root development and brassinolide signaling in Arabidopsis thaliana.	Phosphatidylcholines	6-25	non-specific phospholipase C3	Arabidopsis thaliana	55-59
20332534-8	2010	Moreover, deletion of TGL4 in Saccharomyces cerevisiae showed an altered pattern of phosphatidylcholine and PA molecular species.	Phosphatidylcholines	84-103	triacylglycerol lipase	Saccharomyces cerevisiae S288C	22-26
20053799-9	2010	We find that AtPLAIVA and AtPLAIVB are phosphorylated by calcium-dependent protein kinases in vitro and this enhances their activities on phosphatidylcholine but not on phosphatidylglycerol.	Phosphatidylcholines	138-157	PATATIN-like protein 5	Arabidopsis thaliana	26-34
20438709-1	2010	Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines.	Phosphatidylcholines	99-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-69
20438709-1	2010	Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines.	Phosphatidylcholines	99-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	71-74
20424323-5	2010	During epididymal transit, phosphatidylcholine in the membrane of Pla2g3+/+ sperm underwent a dramatic shift in its acyl groups from oleic, linoleic, and arachidonic acids to docosapentaenoic and docosahexaenoic acids, whereas this membrane lipid remodeling event was compromised in sperm from Pla2g3-/- mice.	Phosphatidylcholines	27-46	phospholipase A2, group III	Mus musculus	66-72
20424323-5	2010	During epididymal transit, phosphatidylcholine in the membrane of Pla2g3+/+ sperm underwent a dramatic shift in its acyl groups from oleic, linoleic, and arachidonic acids to docosapentaenoic and docosahexaenoic acids, whereas this membrane lipid remodeling event was compromised in sperm from Pla2g3-/- mice.	Phosphatidylcholines	27-46	phospholipase A2, group III	Mus musculus	294-300
20507939-0	2010	Plant phosphatidylcholine-hydrolyzing phospholipases C NPC3 and NPC4 with roles in root development and brassinolide signaling in Arabidopsis thaliana.	Phosphatidylcholines	6-25	non-specific phospholipase C4	Arabidopsis thaliana	64-68
20332109-0	2010	Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.	Phosphatidylcholines	26-45	phosphatidylinositol transfer protein beta	Homo sapiens	67-75
20422496-1	2010	Class III multidrug resistance P-glycoproteins, Mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.	Phosphatidylcholines	157-176	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	48-52
20422496-1	2010	Class III multidrug resistance P-glycoproteins, Mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.	Phosphatidylcholines	157-176	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	65-69
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 4	Homo sapiens	112-116
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	121-125
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 4	Homo sapiens	215-219
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 4	Homo sapiens	222-227
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	233-237
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	240-246
20364851-0	2010	C-reactive protein induced rearrangement of phosphatidylcholine on nanoparticle mimics of lipoprotein particles.	Phosphatidylcholines	44-63	C-reactive protein	Homo sapiens	0-18
20150657-2	2010	Another major pathway for phosphatidylcholine biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	26-45	phosphatidylethanolamine N-methyltransferase	Mus musculus	84-128
20150657-2	2010	Another major pathway for phosphatidylcholine biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	26-45	phosphatidylethanolamine N-methyltransferase	Mus musculus	130-134
20442372-8	2010	Observations that recombinant ACBP3 binds PC, PE, and unsaturated acyl-CoAs in vitro and that ACBP3 overexpression enhances degradation of the autophagy (ATG)-related protein ATG8 and disrupts autophagosome formation suggest a role for ACBP3 as a phospholipid binding protein involved in the regulation of leaf senescence by modulating membrane phospholipid metabolism and ATG8 stability in Arabidopsis.	Phosphatidylcholines	42-44	acyl-CoA-binding domain 3	Arabidopsis thaliana	30-35
20332109-2	2010	Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear.	Phosphatidylcholines	125-144	phosphatidylinositol transfer protein beta	Homo sapiens	0-42
20332109-2	2010	Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear.	Phosphatidylcholines	125-144	phosphatidylinositol transfer protein beta	Homo sapiens	44-52
20332109-2	2010	Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear.	Phosphatidylcholines	146-152	phosphatidylinositol transfer protein beta	Homo sapiens	0-42
20332109-2	2010	Phosphatidylinositol transfer protein beta (PITPbeta), an essential protein that possesses phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho) lipid transfer activity is known to localise to the Golgi and ER but its role in these membrane systems is not clear.	Phosphatidylcholines	146-152	phosphatidylinositol transfer protein beta	Homo sapiens	44-52
20210361-3	2010	In this study, turbidity measurements were conducted to provide a detailed description of the binding reaction between IAPP fibrils and lipid vesicles made from phosphatidylcholine.	Phosphatidylcholines	161-180	islet amyloid polypeptide	Homo sapiens	119-123
20026284-6	2010	Although choline kinase activity is decreased in forelimb muscles of Chkb(-/-) mice, the activity of CTP:phosphocholine cytidylyltransferase is increased, resulting in enhanced phosphatidylcholine biosynthesis.	Phosphatidylcholines	177-196	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	101-140
19892352-2	2010	Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT).	Phosphatidylcholines	0-19	lecithin-cholesterol acyltransferase	Homo sapiens	194-230
19892352-2	2010	Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT).	Phosphatidylcholines	0-19	lecithin-cholesterol acyltransferase	Homo sapiens	232-236
19892352-2	2010	Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT).	Phosphatidylcholines	21-23	lecithin-cholesterol acyltransferase	Homo sapiens	194-230
19892352-2	2010	Phosphatidylcholine (PC) is the most important phospholipid in RCT because it is the essential cholesterol-binding component of lipoproteins and is the acyl donor in the esterification of FC by lecithin:cholesterol acyltransferase (LCAT).	Phosphatidylcholines	21-23	lecithin-cholesterol acyltransferase	Homo sapiens	232-236
20045741-2	2010	The rate-limiting step for phosphatidylcholine biosynthesis by the CDP-choline pathway is also the second step, which is catalyzed by CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	27-46	cut-like homeobox 1	Mus musculus	67-70
20045741-2	2010	The rate-limiting step for phosphatidylcholine biosynthesis by the CDP-choline pathway is also the second step, which is catalyzed by CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	27-46	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	134-173
20096375-1	2010	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a key enzyme for phosphatidylcholine biosynthesis in mammalian cells.	Phosphatidylcholines	77-96	phosphate cytidylyltransferase 1A, choline	Homo sapiens	0-45
20193962-6	2010	The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes.	Phosphatidylcholines	112-114	BCL2 apoptosis regulator	Homo sapiens	47-52
20096375-1	2010	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a key enzyme for phosphatidylcholine biosynthesis in mammalian cells.	Phosphatidylcholines	77-96	phosphate cytidylyltransferase 1A, choline	Homo sapiens	47-55
20096375-8	2010	In conclusion, the present results allowed us to portray the clearest picture of the CCTalpha-gene expression in proliferating cells, and understand the mechanism by which cells coordinate cell cycle progression with the requirement for phosphatidylcholine.	Phosphatidylcholines	237-256	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	85-93
20193962-6	2010	The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes.	Phosphatidylcholines	112-114	BCL2 like 1	Homo sapiens	57-63
20193962-6	2010	The peptide corresponding to the BH4 domain of Bcl-2 and Bcl-xL proteins stimulated the BI-1 activities in 100% PC membranes.	Phosphatidylcholines	112-114	transmembrane BAX inhibitor motif containing 6	Homo sapiens	88-92
20114052-8	2010	When incubated with reconstituted phosphatidylcholine bilayers, the E46K protein formed channels that are five times less conductive than those formed by wild-type alpha-syn, exhibit a higher selectivity for cations, and present an asymmetrical response to voltage and nonstop single-channel activity.	Phosphatidylcholines	34-53	synuclein alpha	Homo sapiens	164-173
20392582-4	2010	The group provides now a solid evidence that endogenous lipid synthesis generates a discrete phosphatidylcholine species, 1-palmitoyl 2-oleyl phosphatidylcholine (16:0/18:1 PC), that serves as an endogenous ligand for PPARalpha.	Phosphatidylcholines	93-112	peroxisome proliferator activated receptor alpha	Homo sapiens	218-227
20007511-2	2010	Phosphatidylcholine, an indispensible membrane component, requires the enzyme CCTalpha for its biosynthesis.	Phosphatidylcholines	0-19	t-complex 1	Homo sapiens	78-86
20007511-8	2010	14-3-3zeta was critically involved in preserving phosphatidylcholine synthesis and cell viability in a model of Pseudomonas aeruginosa infection where Ca(2+) concentrations increase within epithelia.	Phosphatidylcholines	49-68	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	0-10
19778326-14	2010	CONCLUSION: This is the first report to show the presence of apolipoprotein B and apolipoprotein B- oxidized phosphatidylcholine complex, which correspond to LDL and OxLDL, respectively, in gingival crevicular fluid.	Phosphatidylcholines	109-128	apolipoprotein B	Homo sapiens	82-98
19878733-7	2010	On day 7 mRNA expression of inducible NO synthase and nitrite/nitrate levels in BALF were higher in VENT than in ECMO, interleukin-8 mRNA expression and lung apoptosis were lower in ENOS than in ECMO; disaturated phosphatidylcholine and mRNA expression of hepatocyte growth factor were higher, interleukin-8 content, NO synthase mRNA expression and malondialdehyde in lung tissue were lower, and morphologically lung injury and apoptosis were milder, in ENOS than in VENT.	Phosphatidylcholines	213-232	nitric oxide synthase 2	Homo sapiens	28-49
20371992-3	2010	We have demonstrated that Abeta binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the liquid crystalline phase by using fluorescence and circular dichroism spectroscopy.	Phosphatidylcholines	45-64	amyloid beta precursor protein	Homo sapiens	26-31
20371992-5	2010	Tightly packed phosphatidylcholine membranes appear to serve as a platform for non-electrostatic binding and self-association of Abeta.	Phosphatidylcholines	15-34	amyloid beta precursor protein	Homo sapiens	129-134
20166680-6	2010	Incorporation of linoleic acid into phosphatidylcholine-containing model vesicles enabled them to interact with the C1q globular domain and to trigger C1 activation, and cholesterol enhanced both processes by facilitating incorporation of the fatty acid into the vesicles.	Phosphatidylcholines	36-55	complement C1q A chain	Homo sapiens	116-119
20303856-6	2010	Although dianionic PA does not play a role in nAChR function, we found that both the stabilization of monoanionic PA and the concentration of other cations at the bilayer surface can account for changes in bilayer physical properties that are observed upon incorporation of the nAChR into 3:2 PC/PA membranes.	Phosphatidylcholines	293-295	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	278-283
19931432-3	2010	PLD incubation of EY mainly converts phosphatidylcholine into phosphatidic acid (PA).	Phosphatidylcholines	37-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
20338039-5	2010	Likewise, treatment with miltefosine produces an interference with the biosynthesis of phosphatidylcholine via both CDP-choline and phosphatidylethanolamine methylation.	Phosphatidylcholines	87-106	cut like homeobox 1	Homo sapiens	116-119
20042613-0	2010	StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria.	Phosphatidylcholines	49-68	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
20107029-4	2010	ACBP1 overexpressors showed reduction in several species of diunsaturated phosphatidylcholine (PC), prompting us to investigate if they were altered in response to freezing stress.	Phosphatidylcholines	95-97	acyl-CoA binding protein 1	Arabidopsis thaliana	0-5
20107029-5	2010	ACBP1 overexpressors demonstrated increased freezing sensitivity accompanied by a decrease in PC and an increase in phosphatidic acid (PA), while acbp1 mutant plants showed enhanced freezing tolerance associated with PC accumulation and PA reduction.	Phosphatidylcholines	94-96	acyl-CoA binding protein 1	Arabidopsis thaliana	0-5
20107029-5	2010	ACBP1 overexpressors demonstrated increased freezing sensitivity accompanied by a decrease in PC and an increase in phosphatidic acid (PA), while acbp1 mutant plants showed enhanced freezing tolerance associated with PC accumulation and PA reduction.	Phosphatidylcholines	217-219	acyl-CoA binding protein 1	Arabidopsis thaliana	146-151
20024669-7	2010	Transient expression of GFP-fused TaAAPT1 and TaAAPT2 proteins in wheat and onion cells indicated they are localized to both the endoplasmic reticulum and Golgi apparatus, suggesting that the final synthesis of PE and PC via the CDP-choline/ethanolamine pathway occurs in these organella.	Phosphatidylcholines	218-220	choline/ethanolaminephosphotransferase 1	Triticum aestivum	34-41
20107029-7	2010	Since phospholipase Dalpha1 (PLDalpha1) is a major enzyme promoting the hydrolysis of PC to PA, PLDalpha1 expression was examined and was observed to be higher in ACBP1 overexpressors than in acbp1 mutant plants.	Phosphatidylcholines	86-88	phospholipase D alpha 1	Arabidopsis thaliana	29-38
20107029-7	2010	Since phospholipase Dalpha1 (PLDalpha1) is a major enzyme promoting the hydrolysis of PC to PA, PLDalpha1 expression was examined and was observed to be higher in ACBP1 overexpressors than in acbp1 mutant plants.	Phosphatidylcholines	86-88	acyl-CoA binding protein 1	Arabidopsis thaliana	163-168
20018880-2	2010	Overexpression of the remodeling enzyme, LPCAT1 (acyl-CoA:lysophosphatidylcholine acyltransferase) in epithelia decreased de novo PtdCho synthesis without significantly altering cellular PtdCho mass.	Phosphatidylcholines	130-136	lysophosphatidylcholine acyltransferase 1	Homo sapiens	41-47
20018880-5	2010	CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis.	Phosphatidylcholines	183-189	choline phosphotransferase 1	Homo sapiens	0-4
19931543-3	2010	For the ErbB2 TM helix inserted into phosphatidylcholine vesicles, the activating V664E mutation was found to induce a transverse shift involving the movement of the E residue toward the membrane surface.	Phosphatidylcholines	37-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-13
19880295-2	2010	In this study the influence of microenvironments such as pH, salt concentration, and surface charge on the secondary structure of a model protein, lysozyme, either in solution or entrapped in liposomes with various molar ratios of phosphatidylcholine (PC):cholesterol (Chol) was investigated.	Phosphatidylcholines	252-254	lysozyme	Homo sapiens	147-155
19895904-7	2010	To assess whether the reduced cellular association mediated by Lp-PLA2 was due to the hydrolysis of oxidized phosphatidylcholine (oxPC), we measured the concentration of lysophosphatidylcholine (lysoPC) in lipoprotein fractions after Lp-PLA2 treatment.	Phosphatidylcholines	109-128	phospholipase A2 group VII	Homo sapiens	63-70
20044023-0	2010	Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme.	Phosphatidylcholines	9-28	phospholipase A2 group IIA	Homo sapiens	85-88
19880374-0	2010	Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS.	Phosphatidylcholines	80-99	solute carrier family 38, member 3	Mus musculus	33-37
19880374-0	2010	Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS.	Phosphatidylcholines	80-99	solute carrier family 38, member 5	Mus musculus	42-46
19880374-1	2010	Endogenous phosphatidylcholine in biological membranes exists as isomers with acyl moieties at the sn-1 or sn-2 positions of the glycerol backbone.	Phosphatidylcholines	11-30	solute carrier family 38, member 3	Mus musculus	99-103
19880374-1	2010	Endogenous phosphatidylcholine in biological membranes exists as isomers with acyl moieties at the sn-1 or sn-2 positions of the glycerol backbone.	Phosphatidylcholines	11-30	solute carrier family 38, member 5	Mus musculus	107-111
19889625-2	2010	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene.	Phosphatidylcholines	82-101	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
19857456-2	2010	Among anionic phospholipids, phosphatidic acid (PA) and cardiolipin specifically increased the catalytic activities, membrane binding affinities, and thermal stabilities of both CYP1B1 proteins when phosphatidylcholine matrix was gradually replaced with these anionic phospholipids.	Phosphatidylcholines	199-218	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	178-184
19889625-2	2010	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene.	Phosphatidylcholines	82-101	phosphatidylethanolamine N-methyltransferase	Homo sapiens	46-50
19889625-2	2010	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene.	Phosphatidylcholines	82-101	phosphatidylethanolamine N-methyltransferase	Homo sapiens	209-213
20410607-0	2010	Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.	Phosphatidylcholines	107-126	solute carrier family 44 member 1	Homo sapiens	50-54
19855431-5	2010	Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways.	Phosphatidylcholines	52-71	phospholipase D2	Homo sapiens	75-91
19855431-5	2010	Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways.	Phosphatidylcholines	52-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	166-195
21079819-10	2010	We demonstrate that recombinant hACBP effectively binds palmitoyl-CoA in vitro, undergoing a shift from a monomeric to a dimeric state, and that this ligand-binding ability is involved in erythrocytic membrane phosphatidylcholine (PC) remodeling but not in protein acylation.	Phosphatidylcholines	210-229	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	32-37
21079819-10	2010	We demonstrate that recombinant hACBP effectively binds palmitoyl-CoA in vitro, undergoing a shift from a monomeric to a dimeric state, and that this ligand-binding ability is involved in erythrocytic membrane phosphatidylcholine (PC) remodeling but not in protein acylation.	Phosphatidylcholines	231-233	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	32-37
20410607-0	2010	Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.	Phosphatidylcholines	107-126	solute carrier family 44 member 2	Homo sapiens	59-63
20462431-0	2010	Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.	Phosphatidylcholines	14-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
19837049-0	2010	Synthesis of oligo(ethylene glycol) substituted phosphatidylcholines: secretory PLA2-targeted precursors of NSAID prodrugs.	Phosphatidylcholines	48-68	phospholipase A2 group IB	Homo sapiens	80-84
19851720-2	2010	The aim of this study was to determine the effectiveness of two types of OMP-associated phosphatidylcholine (PC) liposomal formulations (OMPs-PC, PC-OMPs) and of Zwittergent-based proteomicelles (OMPs-Z) in potentiating an anti-OMP systemic immune response in mice.	Phosphatidylcholines	88-107	olfactory marker protein	Mus musculus	73-76
19841481-1	2009	The Saccharomyces cerevisiae NTE1 gene encodes an evolutionarily conserved phospholipase B localized to the endoplasmic reticulum (ER) that degrades phosphatidylcholine (PC) generating glycerophosphocholine and free fatty acids.	Phosphatidylcholines	149-168	lysophospholipase	Saccharomyces cerevisiae S288C	29-33
21614211-0	2010	Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A2under basal conditions.	Phosphatidylcholines	31-50	plasminogen	Mus musculus	6-17
21614211-1	2010	We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein.	Phosphatidylcholines	125-144	plasminogen	Homo sapiens	26-37
21614211-1	2010	We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein.	Phosphatidylcholines	125-144	plasminogen	Homo sapiens	39-42
20552438-11	2010	Although Rpe65 utilizes an all-trans-RE such as all-trans-retinyl palmitate (all-trans-RP) as substrate, it can be assayed in RPE homogenates by providing all-trans-ROL substrate and allowing the endogenous lecithin:retinol acyl transferase (LRAT) to synthesize all-trans-REs using fatty acids from phosphatidylcholine in the membranes.	Phosphatidylcholines	299-318	RPE65, retinoid isomerohydrolase	Gallus gallus	9-14
19841481-2	2009	We show here that the activity of NTE1-encoded phospholipase B (Nte1p) prevents the attenuation of transcription of genes encoding enzymes involved in phospholipid synthesis in response to increased rates of PC synthesis by affecting the nuclear localization of the transcriptional repressor Opi1p.	Phosphatidylcholines	208-210	lysophospholipase	Saccharomyces cerevisiae S288C	34-38
19841481-2	2009	We show here that the activity of NTE1-encoded phospholipase B (Nte1p) prevents the attenuation of transcription of genes encoding enzymes involved in phospholipid synthesis in response to increased rates of PC synthesis by affecting the nuclear localization of the transcriptional repressor Opi1p.	Phosphatidylcholines	208-210	lysophospholipase	Saccharomyces cerevisiae S288C	64-69
19888882-10	2009	SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride.	Phosphatidylcholines	17-36	sarcolipin	Mus musculus	0-3
19710104-8	2009	However, PC supplementation prevented the TNF-alpha-induced DNA fragmentation, cytochrome-c release and caspase-3 activity in control and CD hepatocytes.	Phosphatidylcholines	9-11	tumor necrosis factor	Rattus norvegicus	42-51
19710104-8	2009	However, PC supplementation prevented the TNF-alpha-induced DNA fragmentation, cytochrome-c release and caspase-3 activity in control and CD hepatocytes.	Phosphatidylcholines	9-11	caspase 3	Rattus norvegicus	104-113
19710104-10	2009	Furthermore, PC is identified as a new survival agent that reverses several TNFalpha-inducible responses that are likely to promote steatosis and necrosis.	Phosphatidylcholines	13-15	tumor necrosis factor	Rattus norvegicus	76-84
19615464-4	2009	The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity.	Phosphatidylcholines	38-58	POU class 2 homeobox 3	Homo sapiens	133-139
19615464-4	2009	The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity.	Phosphatidylcholines	38-58	phospholipase A2 group IB	Homo sapiens	174-180
19615464-4	2009	The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity.	Phosphatidylcholines	60-63	POU class 2 homeobox 3	Homo sapiens	133-139
19615464-4	2009	The proteins were active with various phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), and for most of substrates the PLA(1) activity was much higher than the PLA(2) activity.	Phosphatidylcholines	60-63	phospholipase A2 group IB	Homo sapiens	174-180
19615464-5	2009	In addition, HRASLS2 catalyzed N-acylation of PE to form N-acyl-PE and O-acylation of lyso PC to form PC.	Phosphatidylcholines	91-93	phospholipase A and acyltransferase 2	Homo sapiens	13-20
19888882-10	2009	SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride.	Phosphatidylcholines	17-36	sarcolipin	Mus musculus	38-41
19888882-10	2009	SLN with soybean phosphatidylcholine (SLN-PC) as the lipophilic emulsifier showed a higher drug/prodrug delivery across the skin compared to SLN with Myverol, a palmitinic acid monoglyceride.	Phosphatidylcholines	17-36	sarcolipin	Mus musculus	38-41
19667981-4	2009	RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids.	Phosphatidylcholines	109-128	phospholipase A2 group VII	Homo sapiens	17-24
19766625-7	2009	The perivascular infiltration of the neutrophil leukocytes and the intercellular adhesion molecule-1 (ICAM-1) expressions were reduced only by PC treatment.	Phosphatidylcholines	143-145	intercellular adhesion molecule 1	Rattus norvegicus	67-100
19766625-7	2009	The perivascular infiltration of the neutrophil leukocytes and the intercellular adhesion molecule-1 (ICAM-1) expressions were reduced only by PC treatment.	Phosphatidylcholines	143-145	intercellular adhesion molecule 1	Rattus norvegicus	102-108
19454128-5	2009	Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6.	Phosphatidylcholines	85-104	C-reactive protein	Homo sapiens	53-71
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	interleukin 1 beta	Homo sapiens	209-213
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	interleukin 6	Homo sapiens	215-218
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	C-C motif chemokine ligand 2	Homo sapiens	220-224
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	C-C motif chemokine ligand 5	Homo sapiens	226-230
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	C-X-C motif chemokine ligand 10	Homo sapiens	232-238
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	intercellular adhesion molecule 1	Homo sapiens	244-249
19833868-5	2009	Here we show that a previously unrecognized enzyme, phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), encoded by the Arabidopsis ROD1 gene, is a major reaction for the transfer of 18:1 into PC for desaturation and also for the reverse transfer of 18:2 and 18:3 into the TAG synthesis pathway.	Phosphatidylcholines	52-71	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	148-152
19833868-5	2009	Here we show that a previously unrecognized enzyme, phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), encoded by the Arabidopsis ROD1 gene, is a major reaction for the transfer of 18:1 into PC for desaturation and also for the reverse transfer of 18:2 and 18:3 into the TAG synthesis pathway.	Phosphatidylcholines	209-211	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	148-152
19674157-1	2009	AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3.	Phosphatidylcholines	147-166	ATP binding cassette subfamily B member 4	Homo sapiens	5-35
19674157-1	2009	AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3.	Phosphatidylcholines	147-166	ATP binding cassette subfamily B member 4	Homo sapiens	37-41
19674157-1	2009	AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3.	Phosphatidylcholines	147-166	ATP binding cassette subfamily B member 4	Homo sapiens	42-47
19674157-8	2009	Consequently, ABCB4-mediated phosphatidylcholine translocation activity was significantly reduced when endogenous RACK1 expression was suppressed in HeLa cells.	Phosphatidylcholines	29-48	ATP binding cassette subfamily B member 4	Homo sapiens	14-19
19674157-8	2009	Consequently, ABCB4-mediated phosphatidylcholine translocation activity was significantly reduced when endogenous RACK1 expression was suppressed in HeLa cells.	Phosphatidylcholines	29-48	receptor for activated C kinase 1	Homo sapiens	114-119
19712054-5	2009	The ratios of the lyso derivatives of phosphatidyl choline, ethanolamine and serine obtained here together with the known distribution of these phospholipids among cell membranes, suggest that most PLA(2) hydrolysis takes place on the cell surface.	Phosphatidylcholines	38-58	phospholipase A2 group IIA	Homo sapiens	198-204
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	22-41	interleukin 1 beta	Homo sapiens	154-162
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	22-41	C-C motif chemokine ligand 2	Homo sapiens	171-175
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	43-45	interleukin 1 beta	Homo sapiens	154-162
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	43-45	C-C motif chemokine ligand 2	Homo sapiens	171-175
19501189-6	2009	Purified recombinant cPLA2gamma catalyzed an acyltransferase reaction from one molecule of lysophosphatidylcholine (LPC) to another, forming phosphatidylcholine (PC).	Phosphatidylcholines	95-114	phospholipase A2 group IVC	Homo sapiens	21-31
19501189-6	2009	Purified recombinant cPLA2gamma catalyzed an acyltransferase reaction from one molecule of lysophosphatidylcholine (LPC) to another, forming phosphatidylcholine (PC).	Phosphatidylcholines	117-119	phospholipase A2 group IVC	Homo sapiens	21-31
19667981-4	2009	RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids.	Phosphatidylcholines	109-128	phospholipase A2 group VII	Homo sapiens	40-82
19602573-1	2009	Among mammalian secreted phospholipases A2 (sPLA(2)s), the group X enzyme has the most potent hydrolyzing capacity toward phosphatidylcholine, the major phospholipid of cell membrane and lipoproteins.	Phosphatidylcholines	122-141	phospholipase A2 group IID	Homo sapiens	44-52
19589686-0	2009	Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester.	Phosphatidylcholines	97-116	acyl-CoA binding protein 4	Arabidopsis thaliana	28-33
19589686-0	2009	Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester.	Phosphatidylcholines	97-116	acyl-CoA binding protein 5	Arabidopsis thaliana	38-43
19700561-6	2009	A lipidomics approach revealed that At4g24160 has additional triacylglycerol lipase and phosphatidylcholine hydrolyzing enzymatic activities.	Phosphatidylcholines	88-107	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	36-45
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Phosphatidylcholines	123-125	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	22-26
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Phosphatidylcholines	123-125	phosphorylcholine cytidylyltransferase2	Arabidopsis thaliana	31-35
19667100-9	2009	PC levels were similarly maintained in both mutants and WS plants after 14 d at 2 degrees C, suggesting that either of the CCT genes is sufficient for PC biosynthesis at low temperature.	Phosphatidylcholines	151-153	RNA polymerase II transcription mediator	Arabidopsis thaliana	123-126
19589686-6	2009	Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine.	Phosphatidylcholines	80-99	acyl-CoA binding protein 4	Arabidopsis thaliana	24-29
19589686-6	2009	Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine.	Phosphatidylcholines	80-99	acyl-CoA binding protein 5	Arabidopsis thaliana	34-39
19589686-6	2009	Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine.	Phosphatidylcholines	80-99	acyl-CoA-binding protein 6	Arabidopsis thaliana	49-54
19589686-6	2009	Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine.	Phosphatidylcholines	180-199	acyl-CoA binding protein 4	Arabidopsis thaliana	24-29
19589686-6	2009	Nonetheless, His-tagged ACBP4 and ACBP5 resemble ACBP6 in their ability to bind phosphatidylcholine suggesting that all three ACBPs are available for the intracellular transfer of phosphatidylcholine.	Phosphatidylcholines	180-199	acyl-CoA binding protein 5	Arabidopsis thaliana	34-39
19632995-2	2009	The current view is that cPLA(2)alpha associates with intracellular/phosphatidylcholine-rich membranes strictly via hydrophobic interactions in response to an increase of intracellular calcium.	Phosphatidylcholines	68-87	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	25-37
19345277-1	2009	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
19759306-1	2009	The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho).	Phosphatidylcholines	114-133	patatin-like phospholipase domain containing 6	Mus musculus	11-37
19759306-1	2009	The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho).	Phosphatidylcholines	114-133	patatin-like phospholipase domain containing 6	Mus musculus	39-42
19759306-1	2009	The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho).	Phosphatidylcholines	135-141	patatin-like phospholipase domain containing 6	Mus musculus	11-37
19759306-1	2009	The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho).	Phosphatidylcholines	135-141	patatin-like phospholipase domain containing 6	Mus musculus	39-42
19264150-2	2009	PLD catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA).	Phosphatidylcholines	32-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
19497293-5	2009	Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed.	Phosphatidylcholines	124-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-80
19497293-5	2009	Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed.	Phosphatidylcholines	124-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-85
19720032-0	2009	Interactions of the GM2 activator protein with phosphatidylcholine bilayers: a site-directed spin-labeling power saturation study.	Phosphatidylcholines	47-66	ganglioside GM2 activator	Homo sapiens	20-41
19720032-3	2009	Here, we used site-directed spin labeling with power saturation electron paramagnetic resonance to determine the surface-bound orientation of GM2AP upon phosphatidylcholine vesicles.	Phosphatidylcholines	153-172	ganglioside GM2 activator	Homo sapiens	142-147
19520976-2	2009	We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis.	Phosphatidylcholines	131-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	50-94
19520976-2	2009	We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis.	Phosphatidylcholines	131-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	96-100
19520976-7	2009	The molar ratio of PC/phosphatidylethanolamine in nascent VLDLs produced by Pemt(-/-)/Ldlr(-/-) mice was lower than in VLDLs in Pemt(+/+)/Ldlr(-/-) mice.	Phosphatidylcholines	19-21	phosphatidylethanolamine N-methyltransferase	Mus musculus	76-80
19520976-7	2009	The molar ratio of PC/phosphatidylethanolamine in nascent VLDLs produced by Pemt(-/-)/Ldlr(-/-) mice was lower than in VLDLs in Pemt(+/+)/Ldlr(-/-) mice.	Phosphatidylcholines	19-21	low density lipoprotein receptor	Mus musculus	86-90
19416650-1	2009	Phosphatidylinositol 4,5-bisphosphate-regulated phosphatidylcholine-specific phospholipase D is conserved from yeast to man.	Phosphatidylcholines	48-67	phospholipase D	Saccharomyces cerevisiae S288C	77-92
19345277-1	2009	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
19540357-2	2009	PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion.	Phosphatidylcholines	15-34	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
19527682-4	2009	Bax-C slightly shifted upfield the (31)P resonances coming from phosphatidylglycerol and phosphatidylcholine.	Phosphatidylcholines	89-108	BCL2 associated X, apoptosis regulator	Homo sapiens	0-5
19264893-7	2009	Levels of C32 and C34 n-3 pentaenoic and hexaenoic VLCFA in phosphatidylcholine increased whereas n-6 VLCFAs were depleted.	Phosphatidylcholines	60-79	chemokine-like factor	Mus musculus	10-13
19527682-6	2009	Bax-C substantially decreased the T(1) relaxation times of phosphatidylglycerol and those of phosphatidylcholine when mixtured with phosphatidylglycerol, but T(1) values were not decreased when phosphatidylcholine was the only phospholipid present in the membrane.	Phosphatidylcholines	93-112	BCL2 associated X, apoptosis regulator	Homo sapiens	0-5
19527682-7	2009	(13)C-MAS-NMR showed that T(1) values were decreased when Bax-C was incorporated into the lipid vesicles and this reduction affected similarly to carbons located in different regions of the membrane when the only phospholipid present was phosphatidylcholine.	Phosphatidylcholines	238-257	BCL2 associated X, apoptosis regulator	Homo sapiens	58-63
19540356-2	2009	PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	89-104
19540356-2	2009	PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	106-109
19540356-2	2009	PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely.	Phosphatidylcholines	158-160	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	89-104
19540356-2	2009	PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely.	Phosphatidylcholines	158-160	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	106-109
19620706-0	2009	Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis.	Phosphatidylcholines	88-107	patatin-like phospholipase domain containing 6	Mus musculus	24-50
19620706-2	2009	The authors investigate the effect of neuropathy target esterase inhibition in mouse nervous tissues in vitro on the homeostasis of phosphatidylcholine and lysophosphatidylcholine by treating the homogenates with tri-ortho-cresyl phosphate, paraoxon, paraoxon plus mipafox, and phenylmethylsulfonyl fluoride.	Phosphatidylcholines	132-151	patatin-like phospholipase domain containing 6	Mus musculus	38-64
18989753-1	2009	The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	165-184	lipin 2	Homo sapiens	26-31
19794933-8	2009	On the other hand, PC only increased the secretion of apoA-IV in the presence of lipid micelles.	Phosphatidylcholines	19-21	apolipoprotein A4	Homo sapiens	54-61
19383981-0	2009	Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1.	Phosphatidylcholines	16-35	lysophosphatidylcholine acyltransferase 1	Homo sapiens	45-86
18989753-1	2009	The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	165-184	lipin 3	Homo sapiens	36-41
19215923-0	2009	Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.	Phosphatidylcholines	4-23	toll-like receptor 4	Mus musculus	34-38
19702754-0	2009	A 10-kDa acyl-CoA-binding protein (ACBP) from Brassica napus enhances acyl exchange between acyl-CoA and phosphatidylcholine.	Phosphatidylcholines	105-124	acyl-CoA-binding protein	Brassica napus	35-39
19702754-3	2009	In vitro assays demonstrated that recombinant B. napus ACBP (rBnACBP) strongly increases the formation of phosphatidylcholine (PC) in the absence of added lysophosphatidylcholine in microsomes from DeltaYOR175c yeast expressing A. thaliana lysophosphatidylcholine acyltransferase (AthLPCAT) cDNA or in microsomes from microspore-derived cell suspension cultures of B. napus L. cv.	Phosphatidylcholines	106-125	acyl-CoA-binding protein	Brassica napus	55-59
19657017-4	2009	When expressed in Saccharomyces cerevisiae, FetA localizes partially to the plasma membrane resulting in increased internalization of NBD-labeled phosphatidylethanolamine and phosphatidylcholine, supporting a role for FetA in the inward lipid translocation across cellular membranes.	Phosphatidylcholines	175-194	ATPase, class I, type 8B, member 5	Mus musculus	44-48
19646743-7	2009	Knockdown of Cept1, required for phosphatidylcholine synthesis, suppressed PPARalpha-dependent gene expression.	Phosphatidylcholines	33-52	choline/ethanolamine phosphotransferase 1	Homo sapiens	13-18
19646743-7	2009	Knockdown of Cept1, required for phosphatidylcholine synthesis, suppressed PPARalpha-dependent gene expression.	Phosphatidylcholines	33-52	peroxisome proliferator activated receptor alpha	Homo sapiens	75-84
19215923-3	2009	The aims of this study are to confirm the role of SFAs in TLR4-mediated inflammatory signaling in vascular cells and to propose soy phosphatidylcholine (SPC) as an effective inhibitor against TLR4-mediated agonists.	Phosphatidylcholines	132-151	toll-like receptor 4	Rattus norvegicus	192-196
19215923-0	2009	Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.	Phosphatidylcholines	4-23	mast cell protease 1	Mus musculus	48-53
19074371-4	2009	However, Cav1(-/-)-deficient cells did have a higher proportion of sphingomyelin, decreased abundance of unsaturated phospholipids, and a trend toward shorter fatty acid chains in phosphatidylcholine.	Phosphatidylcholines	180-199	caveolin 1, caveolae protein	Mus musculus	9-13
19351971-7	2009	Electrospray ionization mass spectrometric analysis of phospholipids in Sf9 cells expressing LPCAT3 showed a relative increase in phosphatidylcholine containing saturated acyl chains and a decrease in phosphatidylcholine containing unsaturated acyl chains.	Phosphatidylcholines	130-149	lysophosphatidylcholine acyltransferase 3	Homo sapiens	93-99
19351971-7	2009	Electrospray ionization mass spectrometric analysis of phospholipids in Sf9 cells expressing LPCAT3 showed a relative increase in phosphatidylcholine containing saturated acyl chains and a decrease in phosphatidylcholine containing unsaturated acyl chains.	Phosphatidylcholines	201-220	lysophosphatidylcholine acyltransferase 3	Homo sapiens	93-99
19289606-4	2009	Moreover, the interaction of Hsp70 with PS was demonstrated in artificial unilamellar phosphatidylcholine/ phosphatidylserine (PC/PS) liposomes at the physiological ratio of 8/2.	Phosphatidylcholines	86-105	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
19289606-6	2009	In contrast, only a weak Hsp70 interaction was detected in phosphatidylcholine/phosphatidylglycerol (PC/PG) liposomes, thus demonstrating that the interaction was not a charge-related effect.	Phosphatidylcholines	59-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
19219625-1	2009	Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis.	Phosphatidylcholines	67-86	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	110-152
19542364-4	2009	Pyk2 was activated through phosphatidylcholine-specific phospholipase C (PC-PLC)-, protein kinase C (PKC)-, and Src-regulated pathways.	Phosphatidylcholines	27-46	protein tyrosine kinase 2 beta	Homo sapiens	0-4
19594939-0	2009	TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells.	Phosphatidylcholines	76-95	tumor necrosis factor	Homo sapiens	0-9
19594939-5	2009	It could be demonstrated that the exogenous application of PC inhibits membrane-dependent actin assembly and TNF-alpha-induced nuclear NF-kappaB activation.	Phosphatidylcholines	59-61	tumor necrosis factor	Homo sapiens	109-118
19594939-11	2009	RESULTS: The exogenous addition of all PC species tested significantly inhibited TNF-alpha-induced pro-inflammatory signalling.	Phosphatidylcholines	39-41	tumor necrosis factor	Homo sapiens	81-90
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	intercellular adhesion molecule 1	Homo sapiens	31-37
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	C-X-C motif chemokine ligand 10	Homo sapiens	39-44
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	C-C motif chemokine ligand 2	Homo sapiens	46-51
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	tumor necrosis factor	Homo sapiens	53-62
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	matrix metallopeptidase 1	Homo sapiens	67-72
19594939-16	2009	CONCLUSION: PC induces a prolonged inhibition of TNF-alpha-induced pro-inflammatory signalling.	Phosphatidylcholines	12-14	tumor necrosis factor	Homo sapiens	49-58
19219625-1	2009	Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis.	Phosphatidylcholines	67-86	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	154-158
19219625-1	2009	Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis.	Phosphatidylcholines	88-90	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	110-152
19219625-1	2009	Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis.	Phosphatidylcholines	88-90	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	154-158
19219625-6	2009	To conclude, chronic ethanol consumption impairs PC generation via the PEMT pathway resulting in diminished VLDL secretion which contributes to the development of hepatic steatosis.	Phosphatidylcholines	49-51	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	71-75
19219625-7	2009	By increasing PEMT-mediated PC generation, betaine results in increased fat export from the liver and attenuates the development of alcoholic fatty liver.	Phosphatidylcholines	28-30	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	14-18
19366698-1	2009	Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho).	Phosphatidylcholines	184-203	phospholipid N-methyltransferase	Glycine max	0-32
19540431-7	2009	In addition, the ORX-A- and ghrelin-induced depolarizations were both blocked by D609, a phosphatidylcholine-specific phospholipase C (PLC) inhibitor.	Phosphatidylcholines	89-108	hypocretin neuropeptide precursor	Rattus norvegicus	17-20
19540431-7	2009	In addition, the ORX-A- and ghrelin-induced depolarizations were both blocked by D609, a phosphatidylcholine-specific phospholipase C (PLC) inhibitor.	Phosphatidylcholines	89-108	ghrelin and obestatin prepropeptide	Rattus norvegicus	28-35
19366698-1	2009	Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho).	Phosphatidylcholines	184-203	phospholipid N-methyltransferase	Glycine max	34-38
19366698-1	2009	Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho).	Phosphatidylcholines	205-211	phospholipid N-methyltransferase	Glycine max	0-32
19366698-1	2009	Phospholipid N-methyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho).	Phosphatidylcholines	205-211	phospholipid N-methyltransferase	Glycine max	34-38
19349639-3	2009	It is hypothesized that homeostasis of phosphatidylcholine (PC) and/or lysophosphatidylcholine (LPC) in mice might be disrupted by the OPs since NTE and other phospholipases could be inhibited.	Phosphatidylcholines	60-62	patatin-like phospholipase domain containing 6	Mus musculus	145-148
19327342-0	2009	Cytochrome c induces lipid demixing in weakly charged phosphatidylcholine/phosphatidylglycerol model membranes as evidenced by resonance energy transfer.	Phosphatidylcholines	54-73	cytochrome c, somatic	Homo sapiens	0-12
19327342-1	2009	Resonance energy transfer (RET) between anthrylvinyl-labeled phosphatidylcholine (AV-PC) or phosphatidylglycerol (AV-PG) as donors and the heme groups of cytochrome c (cyt c) as acceptors was examined in PC/PG model membranes containing 10, 20 or 40 mol% PG with an emphasis on evaluating lipid demixing caused by this protein.	Phosphatidylcholines	61-80	cytochrome c, somatic	Homo sapiens	154-166
18837012-5	2009	The MDR1-MDCKII cell membrane has lower ratios of: phospholipid to cholesterol, unsaturated to saturated acyl chains, and phosphatidyl-choline (PC) to sphingomyelin (SM) than brain endothelial cells, making it a poor passive permeability model for BBB.	Phosphatidylcholines	122-142	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
18837012-5	2009	The MDR1-MDCKII cell membrane has lower ratios of: phospholipid to cholesterol, unsaturated to saturated acyl chains, and phosphatidyl-choline (PC) to sphingomyelin (SM) than brain endothelial cells, making it a poor passive permeability model for BBB.	Phosphatidylcholines	144-146	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
19425005-0	2009	Investigation of C-reactive protein binding to phosphatidyl choline by CZE and ESI-mass analysis.	Phosphatidylcholines	47-67	C-reactive protein	Homo sapiens	17-35
19420237-3	2009	We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis.	Phosphatidylcholines	229-248	X-box binding protein 1	Homo sapiens	50-54
19420237-3	2009	We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis.	Phosphatidylcholines	229-248	X-box binding protein 1	Homo sapiens	78-82
19420237-3	2009	We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis.	Phosphatidylcholines	250-256	X-box binding protein 1	Homo sapiens	50-54
19420237-3	2009	We previously demonstrated that overexpression of XBP1(S), the active form of XBP1 generated by UPR-mediated splicing of Xbp1 mRNA, augments the activity of the cytidine diphosphocholine (CDP-choline) pathway for biosynthesis of phosphatidylcholine (PtdCho) and induces ER biogenesis.	Phosphatidylcholines	250-256	X-box binding protein 1	Homo sapiens	78-82
19420237-6	2009	Overexpression of active ATF6alpha induces PtdCho biosynthesis and modulates the CDP-choline pathway differently than does enforced expression of XBP1(S).	Phosphatidylcholines	43-49	activating transcription factor 6	Homo sapiens	25-34
19236939-4	2009	The biosynthesis of phosphatidylcholine (PC) is impaired in the hindlimbs of Chkb -/- mice, with an accumulation of choline and decreased amount of phosphocholine.	Phosphatidylcholines	20-39	choline kinase beta	Mus musculus	77-81
19236939-4	2009	The biosynthesis of phosphatidylcholine (PC) is impaired in the hindlimbs of Chkb -/- mice, with an accumulation of choline and decreased amount of phosphocholine.	Phosphatidylcholines	41-43	choline kinase beta	Mus musculus	77-81
19236939-10	2009	Injection of CDP-choline increased PC content of hindlimb muscle and decreased creatine kinase activity in plasma of Chkb -/- mice.	Phosphatidylcholines	35-37	cut-like homeobox 1	Mus musculus	13-16
19236939-11	2009	We conclude that the hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated PC biosynthesis and enhanced catabolism of PC.	Phosphatidylcholines	87-89	choline kinase beta	Mus musculus	52-56
19236939-11	2009	We conclude that the hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated PC biosynthesis and enhanced catabolism of PC.	Phosphatidylcholines	130-132	choline kinase beta	Mus musculus	52-56
19184454-6	2009	This last result was obtained through the study of structured phosphatidylcholine selective deacylation using a phospholipase A2.	Phosphatidylcholines	62-81	phospholipase A2 group IB	Homo sapiens	112-128
19098306-1	2009	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.	Phosphatidylcholines	114-133	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
19098306-2	2009	However, CCTalpha is cytoplasmic in cells with increased capacity for PtdCho synthesis and following acute activation, suggesting that nuclear export is linked to activation.	Phosphatidylcholines	70-76	choline-phosphate cytidylyltransferase A	Cricetulus griseus	9-17
19098306-1	2009	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.	Phosphatidylcholines	114-133	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-55
19098306-1	2009	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.	Phosphatidylcholines	135-141	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
19098306-1	2009	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.	Phosphatidylcholines	135-141	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-55
19114730-5	2009	Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion.	Phosphatidylcholines	52-54	GLI family zinc finger 2	Homo sapiens	72-77
19415669-0	2009	Physiological phosphatidylcholine protects bovine beta-lactoglobulin from simulated gastrointestinal proteolysis.	Phosphatidylcholines	14-33	beta-lactoglobulin	Bos taurus	50-68
19114730-5	2009	Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion.	Phosphatidylcholines	52-54	intercellular adhesion molecule 1	Homo sapiens	95-101
18937360-3	2009	P-gp was reconstituted in egg-phosphatidylcholine (PhC) liposomes with or without cholesterol, 1,2-dipalmitoyl-phosphatidylcholine (DPPC), alpha-tocopherol (alpha-Toc) or 2,2,5,7,8-pentamethyl-6-chromanol (PMC).	Phosphatidylcholines	30-49	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
19018976-1	2009	BACKGROUND AND AIMS: Mutations in the gene encoding the ABCB4 [adenosine triphosphate (ATP)-binding cassette, sub-family B (MDR/TAP), member 4] transporter lower phosphatidylcholine output into bile and contribute to cholesterol gallstone formation by decreasing the solubility of cholesterol in bile.	Phosphatidylcholines	162-181	ATP binding cassette subfamily B member 4	Homo sapiens	56-61
19415669-1	2009	We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis.	Phosphatidylcholines	35-54	beta-lactoglobulin	Bos taurus	88-106
19415669-1	2009	We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis.	Phosphatidylcholines	35-54	beta-lactoglobulin	Bos taurus	108-115
19415669-1	2009	We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis.	Phosphatidylcholines	56-58	beta-lactoglobulin	Bos taurus	88-106
19415669-1	2009	We have investigated the effect of phosphatidylcholine (PC) on the resistance of bovine beta-lactoglobulin (beta-Lg) to simulated in vitro gastrointestinal proteolysis.	Phosphatidylcholines	56-58	beta-lactoglobulin	Bos taurus	108-115
19342656-5	2009	By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline.	Phosphatidylcholines	156-176	CD1d molecule	Homo sapiens	59-63
19389349-1	2009	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid and choline.	Phosphatidylcholines	33-52	Phospholipase D	Drosophila melanogaster	17-20
19342656-5	2009	By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline.	Phosphatidylcholines	289-309	CD1d molecule	Homo sapiens	59-63
19342656-5	2009	By using multiple mass spectrometry methods, we found that CD1d retained in the ER is predominantly loaded with the most abundant phospholipid in the cell, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline.	Phosphatidylcholines	289-309	CD1d molecule	Homo sapiens	218-222
19342656-6	2009	The secreted soluble version of CD1d, in contrast, lacks detectable phosphatidyl choline and the only detectable associated lipid is sphingomyelin.	Phosphatidylcholines	68-88	CD1d molecule	Homo sapiens	32-36
19714900-0	2009	Specular neutron reflectivity studies of the interaction of cytochrome c with supported phosphatidylcholine bilayers doped with phosphatidylserine.	Phosphatidylcholines	88-107	cytochrome c, somatic	Homo sapiens	60-72
19129178-1	2009	A protein known to regulate both lipid metabolism and vesicular transport is the phosphatidylcholine/phosphatidylinositol transfer protein Sec14 of Saccharomyces cerevisiae.	Phosphatidylcholines	81-100	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	139-144
19164803-5	2009	Phosphatidylcholine on LDL from LDLR(-/-) mice fed either a chow or Western diet was hydrolyzed to a greater extent (61.1+/-0.4% and 45.3+/-4.6%) than the corresponding fractions from apoE(-/-) mice (41.7+/-3.6% and 39.4+/-1.2%).	Phosphatidylcholines	0-19	low density lipoprotein receptor	Mus musculus	32-36
19164803-5	2009	Phosphatidylcholine on LDL from LDLR(-/-) mice fed either a chow or Western diet was hydrolyzed to a greater extent (61.1+/-0.4% and 45.3+/-4.6%) than the corresponding fractions from apoE(-/-) mice (41.7+/-3.6% and 39.4+/-1.2%).	Phosphatidylcholines	0-19	apolipoprotein E	Mus musculus	184-188
19416660-4	2009	Here we show that purified recombinant Drosophila tafazzin exchanges acyl groups between cardiolipin and phosphatidylcholine by a combination of forward and reverse transacylations.	Phosphatidylcholines	105-124	Tafazzin	Drosophila melanogaster	50-58
19185004-3	2009	The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion.	Phosphatidylcholines	236-255	ATP binding cassette subfamily B member 4	Homo sapiens	121-143
19185004-3	2009	The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion.	Phosphatidylcholines	236-255	ATP binding cassette subfamily B member 4	Homo sapiens	145-149
19302798-2	2009	The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1).	Phosphatidylcholines	88-107	synaptotagmin 1	Homo sapiens	24-28
19302798-2	2009	The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1).	Phosphatidylcholines	88-107	secretoglobin family 2B member 3, pseudogene	Homo sapiens	30-33
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	125-144	Lem3p	Saccharomyces cerevisiae S288C	13-17
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	125-144	Lem3p	Saccharomyces cerevisiae S288C	18-22
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	125-144	Lem3p	Saccharomyces cerevisiae S288C	71-76
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	146-148	Lem3p	Saccharomyces cerevisiae S288C	13-17
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	146-148	Lem3p	Saccharomyces cerevisiae S288C	18-22
19270412-3	2009	Mutations in LEM3/ROS3 impaired growth in that medium, indicating that Lem3p is involved in the utilization of extracellular phosphatidylcholine (PC) with short acyl chains.	Phosphatidylcholines	146-148	Lem3p	Saccharomyces cerevisiae S288C	71-76
19141610-0	2009	The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis.	Phosphatidylcholines	55-74	karyopherin alpha	Saccharomyces cerevisiae S288C	4-9
19351232-1	2009	Citicoline (cytidine-5"-diphosphocholine or CDP-choline) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischemia to free fatty acids and free radicals.	Phosphatidylcholines	103-122	cut like homeobox 1	Homo sapiens	44-47
19185004-3	2009	The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion.	Phosphatidylcholines	236-255	ATP binding cassette subfamily B member 4	Homo sapiens	113-118
19047760-3	2009	Here, we show that recombinant H-Rev107s from rat, human, and mouse possess phospholipase (PL) A1 or A2 activity toward phosphatidylcholine (PC).	Phosphatidylcholines	120-139	phospholipase A and acyltransferase 3	Rattus norvegicus	31-39
19047760-3	2009	Here, we show that recombinant H-Rev107s from rat, human, and mouse possess phospholipase (PL) A1 or A2 activity toward phosphatidylcholine (PC).	Phosphatidylcholines	141-143	phospholipase A and acyltransferase 3	Rattus norvegicus	31-39
19346733-9	2009	The present study shows that the common SNP (C to T substitution) in the first intron of the FACL4 gene is associated with altered FA composition of plasma phosphatidylcholines in patients with MetS.	Phosphatidylcholines	156-176	acyl-CoA synthetase long chain family member 4	Homo sapiens	93-98
19270412-0	2009	Involvement of LEM3/ROS3 in the uptake of phosphatidylcholine with short acyl chains in Saccharomyces cerevisiae.	Phosphatidylcholines	42-61	Lem3p	Saccharomyces cerevisiae S288C	15-19
19270412-0	2009	Involvement of LEM3/ROS3 in the uptake of phosphatidylcholine with short acyl chains in Saccharomyces cerevisiae.	Phosphatidylcholines	42-61	Lem3p	Saccharomyces cerevisiae S288C	20-24
19141610-0	2009	The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis.	Phosphatidylcholines	55-74	karyopherin beta	Saccharomyces cerevisiae S288C	10-15
19159281-8	2009	Phospholipase A2, which hydrolyses phosphatidylcholine to Acyl-GPC, is a known modifier gene of the model phenotype (Mom1), and altered expression of choline phospholipid enzymes has been reported in gut tissue from Apc(Min/+) mice.	Phosphatidylcholines	35-54	phospholipase A2, group IB, pancreas	Mus musculus	0-16
19141610-3	2009	In S. cerevisiae, the rate-determining step in the synthesis of phosphatidylcholine via the CDP-choline pathway is catalyzed by Pct1.	Phosphatidylcholines	64-83	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	128-132
19141610-9	2009	Diminution of Kap95 function resulted in almost complete ablation of phosphatidylcholine synthesis under conditions where Pct1 was extranuclear.	Phosphatidylcholines	69-88	karyopherin beta	Saccharomyces cerevisiae S288C	14-19
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	172-174	phosphatidylserine synthase 1	Homo sapiens	97-101
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	172-174	phosphatidylserine synthase 1	Homo sapiens	103-116
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	172-174	phosphatidylserine synthase 2	Homo sapiens	122-126
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	176-195	phosphatidylserine synthase 1	Homo sapiens	97-101
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	176-195	phosphatidylserine synthase 1	Homo sapiens	103-116
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylcholines	176-195	phosphatidylserine synthase 2	Homo sapiens	122-126
19014349-4	2009	The purified PSS2 was shown to catalyse the conversion of PE, but not PC, into PS, this being consistent with the substrate specificity observed in intact cells.	Phosphatidylcholines	70-72	phosphatidylserine synthase 2	Homo sapiens	13-17
19014349-5	2009	On the other hand, the purified PSS1 was shown to catalyse the conversion of both PC and PE into PS, although PSS1 in intact cells had been shown not to contribute to the conversion of PE into PS to a significant extent.	Phosphatidylcholines	82-84	phosphatidylserine synthase 1	Homo sapiens	32-36
19250629-5	2009	Abhd2 deficiency resulted in a decreased level of phosphatidylcholine in the bronchoalveolar lavage.	Phosphatidylcholines	50-69	abhydrolase domain containing 2	Mus musculus	0-5
18983994-1	2009	The effect of cytochrome c (cyt c) on degradation of cardiolipin in its polar part was investigated in cardiolipin/phosphatidylcholine (CL/PC) liposomes incubated with cyt c/H(2)O(2)/and (or) ascorbate by high-performance thin layer chromatography and MALDI-TOF mass spectrometry.	Phosphatidylcholines	115-134	cytochrome c, somatic	Homo sapiens	14-26
18983994-1	2009	The effect of cytochrome c (cyt c) on degradation of cardiolipin in its polar part was investigated in cardiolipin/phosphatidylcholine (CL/PC) liposomes incubated with cyt c/H(2)O(2)/and (or) ascorbate by high-performance thin layer chromatography and MALDI-TOF mass spectrometry.	Phosphatidylcholines	115-134	cytochrome c, somatic	Homo sapiens	28-33
19579625-5	2009	Expressions of caspase-8, -3 and PARP after phosphatidylcholine stimulation were examined by immunoblotting.	Phosphatidylcholines	44-63	caspase 8	Homo sapiens	15-28
19579625-5	2009	Expressions of caspase-8, -3 and PARP after phosphatidylcholine stimulation were examined by immunoblotting.	Phosphatidylcholines	44-63	collagen type XI alpha 2 chain	Homo sapiens	33-37
19579625-9	2009	Fas or TNF-alpha ligand followed by phosphatidylcholine stimulation significantly increased apoptotic cells more than by phosphatidylcholine alone (p &lt; 0.05).	Phosphatidylcholines	121-140	tumor necrosis factor	Homo sapiens	7-16
19579625-11	2009	Phosphatidylcholine was assumed to reduce hepatic carcinogenesis by apoptosis induction via the death ligands (Fas and/or TNF-alpha) pathway followed by caspase-8 and -3 inductions.	Phosphatidylcholines	0-19	tumor necrosis factor	Homo sapiens	122-131
19579625-11	2009	Phosphatidylcholine was assumed to reduce hepatic carcinogenesis by apoptosis induction via the death ligands (Fas and/or TNF-alpha) pathway followed by caspase-8 and -3 inductions.	Phosphatidylcholines	0-19	caspase 8	Homo sapiens	153-169
18983488-5	2009	In eight of these volunteers, an infusion of human apoAI reconstituted with phosphatidylcholine (apoAI-PC; 80 mg kg(-1) body weight) preceded rhCRP infusion.	Phosphatidylcholines	76-95	apolipoprotein A1	Homo sapiens	51-56
18980580-3	2009	[(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope).	Phosphatidylcholines	150-156	choline-phosphate cytidylyltransferase A	Cricetulus griseus	195-203
18980580-3	2009	[(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope).	Phosphatidylcholines	150-156	choline-phosphate cytidylyltransferase A	Cricetulus griseus	205-250
18980580-7	2009	25OH activated CCTalpha in CHO-SCAP D443N cells leading to a transient increase in PtdCho synthesis and accumulation of CDP-choline.	Phosphatidylcholines	83-89	choline-phosphate cytidylyltransferase A	Cricetulus griseus	15-23
18980580-7	2009	25OH activated CCTalpha in CHO-SCAP D443N cells leading to a transient increase in PtdCho synthesis and accumulation of CDP-choline.	Phosphatidylcholines	83-89	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	31-35
18980580-0	2009	Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope.	Phosphatidylcholines	24-43	choline-phosphate cytidylyltransferase A	Cricetulus griseus	63-108
19146388-4	2009	Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline.	Phosphatidylcholines	105-124	synuclein alpha	Homo sapiens	44-52
19146388-4	2009	Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline.	Phosphatidylcholines	105-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-80
19146388-4	2009	Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline.	Phosphatidylcholines	105-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-85
19059204-4	2009	It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA.	Phosphatidylcholines	233-252	phospholamban	Homo sapiens	169-172
19059204-4	2009	It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA.	Phosphatidylcholines	233-252	phospholamban	Homo sapiens	174-181
19059204-4	2009	It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA.	Phosphatidylcholines	254-256	phospholamban	Homo sapiens	169-172
19059204-4	2009	It is shown using solid-state NMR and isothermal titration calorimetry (ITC) that an N-terminally acetylated peptide representing the first 23 N-terminal amino acids of PLB (PLB1-23) interacts with membranes composed of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylglycerol (PG) lipids in the absence and presence of SERCA.	Phosphatidylcholines	254-256	phospholamban	Homo sapiens	174-181
19059204-5	2009	Functional measurements of SERCA in sarcoplasmic reticulum (SR) vesicles, planar SR membranes and reconstituted into PC/PG membranes indicate that PLB1-23 lowers the maximal rate of ATP hydrolysis by acting at the cytoplasmic face of the enzyme.	Phosphatidylcholines	117-119	phospholamban	Homo sapiens	147-154
18983488-5	2009	In eight of these volunteers, an infusion of human apoAI reconstituted with phosphatidylcholine (apoAI-PC; 80 mg kg(-1) body weight) preceded rhCRP infusion.	Phosphatidylcholines	76-95	apolipoprotein A1	Homo sapiens	97-102
19059242-3	2009	Cytochrome c peroxidase activity and Trp59 fluorescence increase in the sequence of phosphatidyl choline (PC)--&gt;phosphatidylserine (PS)--&gt;cardiolipin (CL)--&gt;phosphatidic acid (PA).	Phosphatidylcholines	84-104	cytochrome c, somatic	Homo sapiens	0-12
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	steroidogenic acute regulatory protein	Homo sapiens	112-118
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 3	Homo sapiens	119-127
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 5	Homo sapiens	129-135
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	phosphatidylcholine transfer protein	Homo sapiens	137-143
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 10	Homo sapiens	144-151
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 10	Homo sapiens	153-160
19239851-6	2009	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	ceramide transporter 1	Homo sapiens	165-172
19059242-3	2009	Cytochrome c peroxidase activity and Trp59 fluorescence increase in the sequence of phosphatidyl choline (PC)--&gt;phosphatidylserine (PS)--&gt;cardiolipin (CL)--&gt;phosphatidic acid (PA).	Phosphatidylcholines	106-108	cytochrome c, somatic	Homo sapiens	0-12
19102680-4	2009	Analysis of the data using a kinetic model has suggested an allosteric mechanism for the rate increase of hPLA2 by cholate and also for the rate-lowering effect by certain bile salts or cembranoids on the cholate-activated hPLA2 hydrolysis of phosphatidylcholine vesicles.	Phosphatidylcholines	243-262	phospholipase A2 group IB	Homo sapiens	106-111
18988890-9	2009	Moreover, EL expression was positively associated with lysophosphatidylcholine production and inversely with phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin levels.	Phosphatidylcholines	59-78	lipase G, endothelial type	Homo sapiens	10-12
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	48-52
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	65-69
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	202-206
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	208-213
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	339-344
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	202-206
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	479-484
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	202-206
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	202-206
19273348-1	2009	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future.	Phosphatidylcholines	157-176	ATP binding cassette subfamily B member 4	Homo sapiens	479-484
18974965-3	2009	In the present study, we report that lysophosphatidylcholine acyltransferase 1 (LPCAT1; NM_024830.3), the enzyme that converts lysophosphatidylcholine into phosphatidylcholine, was highly overexpressed in colorectal adenocarcinomas when compared to normal mucosas.	Phosphatidylcholines	41-60	lysophosphatidylcholine acyltransferase 1	Homo sapiens	80-86
18974965-7	2009	In cultured cells, overexpressed LPCAT1 enhanced the incorporation of [(14)C]palmitate into phosphatidylcholine.	Phosphatidylcholines	92-111	lysophosphatidylcholine acyltransferase 1	Homo sapiens	33-39
18974965-9	2009	We conclude that LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy.	Phosphatidylcholines	84-103	lysophosphatidylcholine acyltransferase 1	Homo sapiens	17-23
19102680-4	2009	Analysis of the data using a kinetic model has suggested an allosteric mechanism for the rate increase of hPLA2 by cholate and also for the rate-lowering effect by certain bile salts or cembranoids on the cholate-activated hPLA2 hydrolysis of phosphatidylcholine vesicles.	Phosphatidylcholines	243-262	phospholipase A2 group IB	Homo sapiens	223-228
18988706-4	2009	Here, we report the first crystal structure of the SF-1 LBD bound by the exchanged phosphatidylcholine.	Phosphatidylcholines	83-102	splicing factor 1	Homo sapiens	51-55
18495456-8	2009	However, the MTHFR C677T genotype, alone or together with a diet, influenced betaine (P=.03) and phosphatidylcholine (P=.03).	Phosphatidylcholines	97-116	methylenetetrahydrofolate reductase	Homo sapiens	13-18
19160674-1	2009	Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine.	Phosphatidylcholines	97-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
19160674-1	2009	Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine.	Phosphatidylcholines	97-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
19016452-11	2009	In addition, this study presents evidence suggesting a specific role for phospholipase A2-mediated PtdCho catabolism.	Phosphatidylcholines	99-105	phospholipase A2, group IB, pancreas	Mus musculus	73-89
18842580-5	2008	mpk1Delta cells also exhibit severe defects in lipid metabolism, including an abnormal accumulation of phosphatidylcholine, diacylglycerol, triacylglycerol, and free sterols, as well as aberrant turnover of phosphatidylcholine.	Phosphatidylcholines	103-122	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	0-4
18842588-1	2008	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	121-140	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
18842588-1	2008	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	121-140	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
18842588-1	2008	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	142-144	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
18842588-1	2008	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	142-144	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
18842588-2	2008	Mice that lack PEMT have reduced plasma levels of PC and cholesterol in high density lipoproteins (HDL).	Phosphatidylcholines	50-52	phosphatidylethanolamine N-methyltransferase	Mus musculus	15-19
18842588-6	2008	Moreover, hepatocytes isolated from Pemt(-/-) mice released cholesterol and PC into the medium as efficiently as did hepatocytes from Pemt(+/+) mice.	Phosphatidylcholines	76-78	phosphatidylethanolamine N-methyltransferase	Mus musculus	36-40
18931395-7	2008	The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p.	Phosphatidylcholines	77-96	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	284-289
18931395-7	2008	The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p.	Phosphatidylcholines	77-96	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	294-299
19116882-8	2009	DHA and DHA-rich phosphatidylcholine decreased Bcl-2 level in HT-29 and Caco-2 cells.	Phosphatidylcholines	17-36	BCL2 apoptosis regulator	Homo sapiens	47-52
18835908-0	2008	Behavioral differences between phosphatidic acid and phosphatidylcholine in the presence of the nicotinic acetylcholine receptor.	Phosphatidylcholines	53-72	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	96-128
18842580-5	2008	mpk1Delta cells also exhibit severe defects in lipid metabolism, including an abnormal accumulation of phosphatidylcholine, diacylglycerol, triacylglycerol, and free sterols, as well as aberrant turnover of phosphatidylcholine.	Phosphatidylcholines	207-226	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	0-4
18629440-5	2008	hPLSCR1 showed higher rates of scrambling activity for phosphatidylethanolamine than phosphatidylcholine.	Phosphatidylcholines	85-104	phospholipid scramblase 1	Homo sapiens	0-7
18762160-1	2008	Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro.	Phosphatidylcholines	161-181	phosphatidylcholine transfer protein	Mus musculus	0-36
18762160-1	2008	Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro.	Phosphatidylcholines	161-181	phosphatidylcholine transfer protein	Mus musculus	38-43
18762160-1	2008	Phosphatidylcholine transfer protein (PC-TP, also referred to as StarD2) is a highly specific intracellular lipid-binding protein that catalyzes the transfer of phosphatidylcholines between membranes in vitro.	Phosphatidylcholines	161-181	phosphatidylcholine transfer protein	Mus musculus	65-71
18762160-3	2008	To begin to address the relationship between activity in vitro and biological function, we undertook a high-throughput screen to identify small-molecule inhibitors of the phosphatidylcholine transfer activity of PC-TP.	Phosphatidylcholines	171-190	phosphatidylcholine transfer protein	Mus musculus	212-217
19017977-11	2008	LPLA(2)(-/-) alveolar macrophages are characterized by marked accumulation of phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	78-97	phospholipase A2, group XV	Mus musculus	0-7
18791037-2	2008	Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine.	Phosphatidylcholines	188-207	lipin 1	Homo sapiens	0-27
18791037-2	2008	Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine.	Phosphatidylcholines	188-207	lipin 1	Homo sapiens	29-33
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	169-188	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
19012176-1	2008	Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
19012176-1	2008	Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
19012176-1	2008	Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	142-145
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2 group IID	Homo sapiens	90-96
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group III	Mus musculus	185-191
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group V	Mus musculus	206-212
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group X	Mus musculus	217-224
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group IIF	Mus musculus	248-255
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	279-286
18801741-5	2008	In vitro incubation of low density (LDL) and high density (HDL) lipoproteins with several sPLA2s showed that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E.	Phosphatidylcholines	109-128	phospholipase A2, group IIE	Mus musculus	291-298
18773301-6	2008	Lipid profile analysis further revealed that an acbp4 knockout mutant showed decreases in membrane lipids (digalactosyldiacylglycerol, monogalactosyldiacylglycerol, phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol) while acbp4-complemented lines attained levels similar to wild type, suggesting that ACBP4 plays a role in the biosynthesis of membrane lipids including galactolipids and phospholipids.	Phosphatidylcholines	165-184	acyl-CoA binding protein 4	Arabidopsis thaliana	48-53
18784085-2	2008	When protein S was added to phosphatidylcholine/phosphatidylserine (PC/PS, 4:1) vesicle-bound DEGR-fXa(i), the anisotropy of the dansyl moiety was altered from 0.219 +/- 0.002 to 0.245 +/- 0.003.	Phosphatidylcholines	28-47	coagulation factor X	Homo sapiens	99-102
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	169-188	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	190-192	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	190-192	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
18755140-3	2008	Fluorescence and circular dichroism spectra have clearly shown that Abeta binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the ripple gel or liquid crystalline phase, indicating the importance of the tight lipid packing characteristic of the lamellar gel phase.	Phosphatidylcholines	87-106	amyloid beta precursor protein	Homo sapiens	68-73
19002082-1	2008	Phosphatidylcholine-specific phospholipase C (PC-PLC) catalyzes the hydrolysis of the ester linkage between glycerol and phosphate in phosphocholine (PC) and other phosphatides, such as sphingomylin (SM) and phosphatidylethanolamine (PE).	Phosphatidylcholines	0-19	heparan sulfate proteoglycan 2	Homo sapiens	49-52
18755140-6	2008	The flat surface of tightly packed phosphatidylcholine membranes appears to serve as a platform for non-electrostatic binding and self-association of Abeta.	Phosphatidylcholines	35-54	amyloid beta precursor protein	Homo sapiens	150-155
18587072-1	2008	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown.	Phosphatidylcholines	105-124	phospholipase A2 group X	Homo sapiens	137-171
18930839-0	2008	Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways.	Phosphatidylcholines	106-125	phospholipid phosphatase 6	Homo sapiens	28-63
18930839-8	2008	PA-PSP overexpression, but not LPRP-A, accelerated the synthesis of phosphatidylcholine and caused accumulation of triacylglycerol with concomitant decrease in the rate of phosphatidylinositol synthesis.	Phosphatidylcholines	68-87	phospholipid phosphatase 6	Homo sapiens	0-6
18930839-9	2008	Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol.	Phosphatidylcholines	113-132	phosphate cytidylyltransferase 1A, choline	Homo sapiens	22-67
18930839-9	2008	Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol.	Phosphatidylcholines	113-132	phospholipid phosphatase 6	Homo sapiens	73-79
18930839-9	2008	Coexpression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhanced the effect of PA-PSP on phosphatidylcholine levels, yet attenuated its effect on triacylglycerol.	Phosphatidylcholines	113-132	phospholipid phosphatase 6	Homo sapiens	103-109
18645209-3	2008	Pure phosphatidylcholine liposomes were persistent against apoA-I at pH levels above 5.0, but were progressively transformed into reconstituted HDLs (rHDLs) by apoA-I at lower pH.	Phosphatidylcholines	5-24	apolipoprotein A1	Homo sapiens	59-65
18645209-3	2008	Pure phosphatidylcholine liposomes were persistent against apoA-I at pH levels above 5.0, but were progressively transformed into reconstituted HDLs (rHDLs) by apoA-I at lower pH.	Phosphatidylcholines	5-24	apolipoprotein A1	Homo sapiens	160-166
18781607-10	2008	Bile from a mutation homozygote showed a reduced phosphatidylcholine/bile acid ratio, consistent with reduced ABCB4 phosphatidylcholine transport activity.	Phosphatidylcholines	116-135	ATP binding cassette subfamily B member 4	Homo sapiens	110-115
19704440-3	2008	Lipid analyses on cold-acclimated freezing-treated ACBP6-overexpressors revealed a decline in phosphatidylcholine (PC) and an elevation of phosphatidic acid (PA) in comparison to wild type.	Phosphatidylcholines	94-113	acyl-CoA-binding protein 6	Arabidopsis thaliana	51-56
19704440-3	2008	Lipid analyses on cold-acclimated freezing-treated ACBP6-overexpressors revealed a decline in phosphatidylcholine (PC) and an elevation of phosphatidic acid (PA) in comparison to wild type.	Phosphatidylcholines	115-117	acyl-CoA-binding protein 6	Arabidopsis thaliana	51-56
19704440-4	2008	Furthermore, the His-tagged ACBP6 recombinant protein was observed using in vitro filter-binding assays to bind PC, but not PA or lysophosphatidylcholine.	Phosphatidylcholines	112-114	acyl-CoA-binding protein 6	Arabidopsis thaliana	28-33
18789905-4	2008	A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	156-175	phosphatidylethanolamine N-methyltransferase	Homo sapiens	189-233
18789905-4	2008	A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	156-175	phosphatidylethanolamine N-methyltransferase	Homo sapiens	235-239
18821587-3	2008	G2A-deficient (G2A(-/-)) mice fed chow had a 25% reduction in biliary phosphatidylcholine content, reduced hepatic gene expression of the phosphatidylcholine transporter adenosine triphosphate-binding cassette B4, and an 8-fold increase in expression of the nuclear receptor liver X receptor (LXR).	Phosphatidylcholines	70-89	G protein-coupled receptor 132	Mus musculus	0-3
18821587-3	2008	G2A-deficient (G2A(-/-)) mice fed chow had a 25% reduction in biliary phosphatidylcholine content, reduced hepatic gene expression of the phosphatidylcholine transporter adenosine triphosphate-binding cassette B4, and an 8-fold increase in expression of the nuclear receptor liver X receptor (LXR).	Phosphatidylcholines	70-89	G protein-coupled receptor 132	Mus musculus	15-18
18587072-1	2008	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown.	Phosphatidylcholines	105-124	phospholipase A2 group X	Homo sapiens	173-178
18587072-1	2008	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown.	Phosphatidylcholines	126-132	phospholipase A2 group X	Homo sapiens	137-171
18587072-1	2008	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown.	Phosphatidylcholines	126-132	phospholipase A2 group X	Homo sapiens	173-178
18587072-1	2008	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown.	Phosphatidylcholines	126-132	phospholipase A2 group X	Homo sapiens	280-285
18587072-4	2008	Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively.	Phosphatidylcholines	78-84	phospholipase A2 group X	Homo sapiens	8-13
18672068-5	2008	The orientation of Bax-C in membranes was also affected by negatively charged lipids, the presence of phosphatidylglycerol reduced the angle it forms with the normal to the germanium plate from 45 degrees in phosphatidylcholine to 27 degrees in phosphatidylglycerol vesicles.	Phosphatidylcholines	208-227	BCL2 associated X, apoptosis regulator	Homo sapiens	19-24
18667535-8	2008	Our analysis revealed that overexpression of Hmg2p caused significant and specific growth defects in nulls of the methylation pathway for phosphatidylcholine biosynthesis that includes the Psd1p enzyme.	Phosphatidylcholines	138-157	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	45-50
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	155-174	lysophosphatidylcholine acyltransferase 3	Homo sapiens	61-66
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	155-174	lysophosphatidylcholine acyltransferase 3	Homo sapiens	68-74
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	176-182	lysophosphatidylcholine acyltransferase 3	Homo sapiens	61-66
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	176-182	lysophosphatidylcholine acyltransferase 3	Homo sapiens	68-74
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	236-242	lysophosphatidylcholine acyltransferase 3	Homo sapiens	61-66
18781350-2	2008	Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and modulating fatty acid composition of PtdCho.	Phosphatidylcholines	236-242	lysophosphatidylcholine acyltransferase 3	Homo sapiens	68-74
18667535-8	2008	Our analysis revealed that overexpression of Hmg2p caused significant and specific growth defects in nulls of the methylation pathway for phosphatidylcholine biosynthesis that includes the Psd1p enzyme.	Phosphatidylcholines	138-157	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	189-194
18564386-7	2008	Expression in Escherichia coli revealed that NPC5 shows phospholipase C activity on phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	84-103	non-specific phospholipase C5	Arabidopsis thaliana	45-49
18779284-7	2008	Phosphatidylcholine was modified by MTHFR genotype (P = 0.035; 677TT &lt; 677CC).	Phosphatidylcholines	0-19	methylenetetrahydrofolate reductase	Homo sapiens	36-41
18614529-1	2008	Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTalpha).	Phosphatidylcholines	13-32	phosphate cytidylyltransferase 1A, choline	Homo sapiens	129-137
18614794-6	2008	The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin.	Phosphatidylcholines	74-93	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	111-115
18614794-6	2008	The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin.	Phosphatidylcholines	74-93	oxysterol binding protein	Homo sapiens	158-162
18614794-6	2008	The effect of VAPs on PI4P levels is mediated by the phosphatidylinositol/phosphatidylcholine transfer protein Nir2, which is required for Golgi targeting of OSBP and CERT and the subsequent production of diacylglycerol and sphingomyelin.	Phosphatidylcholines	74-93	ceramide transporter 1	Homo sapiens	167-171
18591246-3	2008	Here we show that down-regulation of SAH1 expression in yeast leads to accumulation of S-adenosyl-L-homocysteine and decreased de novo PC synthesis in vivo.	Phosphatidylcholines	135-137	adenosylhomocysteinase	Saccharomyces cerevisiae S288C	37-41
18523140-1	2008	The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists.	Phosphatidylcholines	4-23	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	47-50
18523140-1	2008	The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists.	Phosphatidylcholines	4-23	phospholipase D2	Homo sapiens	60-64
18523140-1	2008	The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists.	Phosphatidylcholines	4-23	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	30-45
18949627-4	2008	It is shown that asyn increases the permeability to Mn(2+) of both large (200 nm diameter) and small (50 nm diameter) vesicles composed of zwitterionic phosphatidylcholine and anionic phosphatidylglycerol at protein/lipid molar ratios as low as 1:2000.	Phosphatidylcholines	152-171	synuclein alpha	Homo sapiens	17-21
18621979-8	2008	Lipid profiling analyses of rosettes from cold-acclimated, freezing-treated (-8 degrees C) transgenic Arabidopsis plants overexpressing ACBP6 showed a decline in phosphatidylcholine (-36% and -46%) and an elevation of phosphatidic acid (73% and 67%) in comparison with wild-type plants.	Phosphatidylcholines	162-181	acyl-CoA-binding protein 6	Arabidopsis thaliana	136-141
18621979-9	2008	From our comparison, the gain in freezing tolerance in ACBP6 overexpressors that was accompanied by decreases in phosphatidylcholine and an accumulation of phosphatidic acid is consistent with previous findings on phospholipase Ddelta-overexpressing transgenic Arabidopsis.	Phosphatidylcholines	113-132	acyl-CoA-binding protein 6	Arabidopsis thaliana	55-60
18621979-10	2008	In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine.	Phosphatidylcholines	76-95	acyl-CoA-binding protein 6	Arabidopsis thaliana	64-69
18591246-5	2008	TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction.	Phosphatidylcholines	114-116	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	36-40
18591246-5	2008	TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction.	Phosphatidylcholines	114-116	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	45-49
18591246-5	2008	TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction.	Phosphatidylcholines	134-136	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	36-40
18591246-5	2008	TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction.	Phosphatidylcholines	134-136	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	45-49
18423905-3	2008	Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline.	Phosphatidylcholines	6-25	cut-like homeobox 1	Rattus norvegicus	107-110
18667693-2	2008	We previously found that its synthesis from phosphatidylcholine is catalyzed by tonicity-regulated activity of the phospholipase B, neuropathy target esterase.	Phosphatidylcholines	44-63	patatin like phospholipase domain containing 6	Homo sapiens	132-158
18423905-3	2008	Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline.	Phosphatidylcholines	6-25	cut-like homeobox 1	Rattus norvegicus	164-167
18423905-3	2008	Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline.	Phosphatidylcholines	27-29	cut-like homeobox 1	Rattus norvegicus	107-110
18423905-3	2008	Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline.	Phosphatidylcholines	27-29	cut-like homeobox 1	Rattus norvegicus	164-167
18437350-4	2008	METHODS: Inhibition of ApoA-I glycation was assessed by incubating aminoguanidine, pyridoxamine, metformin and alagebrium with mixtures of methylglyoxal and discoidal reconstituted HDL (rHDL) containing phosphatidylcholine and ApoA-I, ([A-I]rHDL).	Phosphatidylcholines	203-222	apolipoprotein A1	Homo sapiens	23-29
18782225-4	2008	In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans.	Phosphatidylcholines	152-171	Lysophospholipid acyltransferase 5	Caenorhabditis elegans	98-104
18782225-4	2008	In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans.	Phosphatidylcholines	173-175	Lysophospholipid acyltransferase 5	Caenorhabditis elegans	98-104
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	18-37	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-68
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	18-37	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	39-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-68
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	39-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
18559668-2	2008	Here, we demonstrate that CCT alpha-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex.	Phosphatidylcholines	45-64	phosphate cytidylyltransferase 1A, choline	Homo sapiens	26-35
18522808-8	2008	Compared to wildtype littermate controls, hearts from Gpat1(-/-)(-/-) mice contained a lower amount of 16:0 in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine/phosphatidylinositol and significantly more C20:4n6.	Phosphatidylcholines	111-130	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	54-59
18522808-9	2008	Phosphatidylcholine and phosphatidylethanolamine from Gpat1(-/-)(-/-) hearts also contained higher amounts of 18:0 and 18:1.	Phosphatidylcholines	0-19	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	54-59
18511424-2	2008	Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis.	Phosphatidylcholines	35-54	phospholipase A2, group X	Mus musculus	153-162
18511424-2	2008	Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis.	Phosphatidylcholines	56-58	phospholipase A2, group X	Mus musculus	153-162
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	92-111	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	17-47
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	92-111	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	49-54
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	92-111	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	76-80
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	113-115	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	17-47
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	113-115	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	49-54
18410282-1	2008	BACKGROUND/AIMS: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2(-/-)) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas.	Phosphatidylcholines	113-115	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	76-80
18410282-8	2008	CONCLUSIONS: Mdr2(-/-) mice maintain stable hepatic, serum and biliary PL metabolism in response to dietary PC manipulations.	Phosphatidylcholines	108-110	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	13-17
18723500-6	2008	Furthermore, we have determined that FASN inhibition results not only in lower phosphatidylcholine levels but also in a 59% drop in the phospholipid precursor phosphocholine (PCho).	Phosphatidylcholines	79-98	fatty acid synthase	Homo sapiens	37-41
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	118-120	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-68
18422860-1	2008	The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA).	Phosphatidylcholines	118-120	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
18398221-5	2008	Using electrospray ionization-mass spectrometry, primarily phosphatidylcholines and phosphatidylethanolamines were increased in iPLA(2)gamma-shRNA-treated cells.	Phosphatidylcholines	59-79	patatin like phospholipase domain containing 8	Homo sapiens	128-140
18506007-1	2008	BACKGROUND: Group X secretory phospholipase A(2) (sPLA(2)-X) has the most potent hydrolyzing activity toward phosphatidylcholine and elicits a marked release of arachidonic acid among several types of sPLA(2).	Phosphatidylcholines	109-128	phospholipase A2, group X	Mus musculus	50-59
18460912-4	2008	ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1.	Phosphatidylcholines	45-64	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
18460912-4	2008	ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1.	Phosphatidylcholines	45-64	apolipoprotein A1	Homo sapiens	68-85
18460912-4	2008	ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1.	Phosphatidylcholines	45-64	apolipoprotein A1	Homo sapiens	121-138
18472009-2	2008	When the content of cardiolipin (CL) in membranes at the expense of phosphatidylcholine matrix was increased, the ROS produced by recombinant human CYP2E1 was decreased as a function of CL concentration.	Phosphatidylcholines	68-87	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	148-154
18343815-3	2008	PSS1 exchanges serine for choline of phosphatidylcholine, whereas PSS2 exchanges ethanolamine of phosphatidylethanolamine for serine.	Phosphatidylcholines	37-56	phosphatidylserine synthase 1	Mus musculus	0-4
18276583-1	2008	In the yeast Saccharomyces cerevisiae, the CKI1-encoded choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine via the CDP-choline branch of the Kennedy pathway.	Phosphatidylcholines	120-139	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	43-47
18423385-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway.	Phosphatidylcholines	76-95	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
18423385-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway.	Phosphatidylcholines	76-95	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
18423385-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
18423385-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis by the Kennedy pathway.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
18423386-1	2008	Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG).	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-52
18423386-1	2008	Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG).	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
18276583-8	2008	The induction of CKI1 expression in zinc-depleted cells translated into increased choline kinase activity in vitro and in vivo, and an increase in phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	147-166	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	17-21
18190795-1	2008	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
18190795-1	2008	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
18164931-2	2008	A chitosan-egg phosphatidylcholine (chitosan-ePC) implant system containing PLA-b-PEG/PLA nanoparticles has been developed for the delivery of paclitaxel to treat ovarian cancer.	Phosphatidylcholines	15-34	transcription factor 21	Mus musculus	45-48
18064630-3	2008	We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN.	Phosphatidylcholines	81-100	fibronectin 1	Homo sapiens	267-269
18064630-3	2008	We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN.	Phosphatidylcholines	102-104	fibronectin 1	Homo sapiens	267-269
18064630-7	2008	We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM.	Phosphatidylcholines	53-55	fibronectin 1	Homo sapiens	205-207
18064630-7	2008	We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM.	Phosphatidylcholines	187-189	fibronectin 1	Homo sapiens	205-207
18335268-9	2008	Additionally, phosphatidylcholines (PCs) with an oxidized acyl chain at sn-2 position were found to be efficient as 1-palmitoyl LPC as substrates of lysoPLD.	Phosphatidylcholines	14-34	ectonucleotide pyrophosphatase/phosphodiesterase 2	Bos taurus	149-156
18335268-9	2008	Additionally, phosphatidylcholines (PCs) with an oxidized acyl chain at sn-2 position were found to be efficient as 1-palmitoyl LPC as substrates of lysoPLD.	Phosphatidylcholines	36-39	ectonucleotide pyrophosphatase/phosphodiesterase 2	Bos taurus	149-156
18432522-1	2008	Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets.	Phosphatidylcholines	40-59	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
18432522-1	2008	Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets.	Phosphatidylcholines	40-59	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
18451614-2	2008	Here, we used apoA-I and its model peptide, Ac-18A-NH(2), to investigate their interaction with mixed membranes of phosphatidylcholine (PC) with phosphatidylethanolamine (PE) or sphingomyelin (SM).	Phosphatidylcholines	115-134	apolipoprotein A1	Homo sapiens	14-20
18451614-2	2008	Here, we used apoA-I and its model peptide, Ac-18A-NH(2), to investigate their interaction with mixed membranes of phosphatidylcholine (PC) with phosphatidylethanolamine (PE) or sphingomyelin (SM).	Phosphatidylcholines	136-138	apolipoprotein A1	Homo sapiens	14-20
18203956-0	2008	Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages.	Phosphatidylcholines	0-19	C-C motif chemokine receptor 5	Homo sapiens	72-76
18166145-3	2008	Although both LL-37 and the mutant intercalated effectively into zwitterionic phosphatidylcholine membranes the presence of acidic phospholipids caused augmented membrane binding.	Phosphatidylcholines	78-97	cathelicidin antimicrobial peptide	Homo sapiens	14-19
18203956-0	2008	Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages.	Phosphatidylcholines	0-19	C-C motif chemokine ligand 2	Homo sapiens	101-105
18203956-0	2008	Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages.	Phosphatidylcholines	0-19	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	146-151
18203956-3	2008	In this study, we show for the first time that the phosphatidylcholine-specific phospholipase C (PC-PLC) is required for the production of CCL2 triggered by gp120 in human monocyte-derived macrophages (MDMs).	Phosphatidylcholines	51-70	C-C motif chemokine ligand 2	Homo sapiens	139-143
18203956-3	2008	In this study, we show for the first time that the phosphatidylcholine-specific phospholipase C (PC-PLC) is required for the production of CCL2 triggered by gp120 in human monocyte-derived macrophages (MDMs).	Phosphatidylcholines	51-70	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	157-162
18081857-4	2008	OBJECTIVE: To evaluate the capability of phosphatidylcholine + deoxycholate + ethanol (PPC/DC/E) to reduce body fat with a half-side pilot study for the reduction of saddlebag trochanteric bulges.	Phosphatidylcholines	41-60	phosphopantothenoylcysteine decarboxylase	Homo sapiens	87-95
18398117-9	2008	Eosinophils, so prominent in asthmatic patients, synthesize the enzyme lysophospholipase, which, together with the enzyme phospholipase A(2), catalyzes the hydrolysis of the main component of the surfactant, phosphatidylcholine.	Phosphatidylcholines	208-227	phospholipase A2 group IVA	Homo sapiens	71-88
18336573-7	2008	The iPLA(2)-VIA effects were found to be independent of the generation of free arachidonic acid or one of its oxygenated metabolites, and may work through regulation of the cellular level of phosphatidylcholine, a structural lipid that is required for cell growth/membrane expansion.	Phosphatidylcholines	191-210	phospholipase A2 group VI	Homo sapiens	4-15
17993484-5	2008	The binding of peptides to membranes was confirmed by surface pressure (Langmuir film balance) measurements using phosphatidylcholine/phosphatidylserine monolayers, which show a significant increase after injection of rat annexin A1 N-terminal peptides.	Phosphatidylcholines	114-133	annexin A1	Rattus norvegicus	222-232
17985365-0	2008	Nonpolar interactions between trans-membrane helical EGF peptide and phosphatidylcholines, sphingomyelins and cholesterol.	Phosphatidylcholines	69-89	epidermal growth factor	Homo sapiens	53-56
18180163-2	2008	Membrane-permeabilizing activities of AM2, AM3, and AM6 were examined using fluorescent-dye leakage experiments with various phosphatidylcholines (PCs) and sterols.	Phosphatidylcholines	125-145	adrenomedullin 2	Homo sapiens	38-41
18180163-2	2008	Membrane-permeabilizing activities of AM2, AM3, and AM6 were examined using fluorescent-dye leakage experiments with various phosphatidylcholines (PCs) and sterols.	Phosphatidylcholines	147-150	adrenomedullin 2	Homo sapiens	38-41
18180163-5	2008	In liposomes consisting of unsaturated PC, AM2, which possesses an additional ether ring in a polyhydroxyl chain, showed membrane-permeabilizing activities with a moderate efficacy, while AM3 or AM6 did not.	Phosphatidylcholines	39-41	adrenomedullin 2	Homo sapiens	43-46
18165686-4	2008	Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL.	Phosphatidylcholines	135-154	phospholipase A2 group VII	Homo sapiens	108-117
18165686-4	2008	Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL.	Phosphatidylcholines	156-158	phospholipase A2 group VII	Homo sapiens	108-117
17588738-9	2008	The response of phosphatidylcholine to folate intake appeared to be influenced by MTHFR C677T genotype.	Phosphatidylcholines	16-35	methylenetetrahydrofolate reductase	Homo sapiens	82-87
18036176-2	2008	PLD1 hydrolyzes phosphatidylcholine to produce phosphatidic acid (PA) and a free choline headgroup.	Phosphatidylcholines	16-35	phospholipase D	Saccharomyces cerevisiae S288C	0-4
18036206-7	2008	In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine.	Phosphatidylcholines	170-189	sinapine esterase	Brassica napus	15-32
18055762-2	2008	Infrared difference spectra show that concentrations of tetracaine consistent with binding to the ion channel (&lt;50 microM) stabilize a resting-like state when the nAChR is reconstituted into phosphatidylcholine membranes containing the anionic lipid, phosphatidic acid, but have no effect on the nAChR reconstituted into membranes lacking phosphatidic acid, either in the presence or absence of cholesterol.	Phosphatidylcholines	194-213	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	166-171
18242748-1	2008	The hepatic transporter Mdr2 is an ATP-binding cassette transporter which excretes phosphatidylcholine into the bile.	Phosphatidylcholines	83-102	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	24-28
18287365-3	2008	The objective of this study was to determine whether homocysteine lowering with a B vitamin supplement affects the proportion of (n-3) long-chain PUFA in plasma phosphatidylcholine.	Phosphatidylcholines	161-180	pumilio RNA binding family member 3	Homo sapiens	146-150
18036206-7	2008	In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine.	Phosphatidylcholines	170-189	sinapine esterase	Brassica napus	72-78
18036206-7	2008	In addition to sinapine esterase activity, the native B. napus protein (BnSCE3/BnLIP2) showed broad substrate specificity towards various other choline esters, including phosphatidylcholine.	Phosphatidylcholines	170-189	sinapine esterase	Brassica napus	79-85
17951297-3	2008	Substitution of 20-60% phosphatidylethanolamine (DOPE) for phosphatidylcholine in the v-SNARE vesicle with either 0 or 20% DOPE included in the t-SNARE bilayer gives rise to hemifusion events.	Phosphatidylcholines	59-78	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	86-93
17951297-3	2008	Substitution of 20-60% phosphatidylethanolamine (DOPE) for phosphatidylcholine in the v-SNARE vesicle with either 0 or 20% DOPE included in the t-SNARE bilayer gives rise to hemifusion events.	Phosphatidylcholines	59-78	small NF90 (ILF3) associated RNA E	Homo sapiens	88-93
17624579-0	2008	Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells.	Phosphatidylcholines	54-73	solute carrier family 6 member 8	Rattus norvegicus	95-114
18243114-1	2008	Sec14, the major yeast phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein, regulates essential interfaces between lipid metabolism and membrane trafficking from the trans-Golgi network (TGN).	Phosphatidylcholines	53-72	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
17982138-1	2008	Sphingomyelin synthase (SMS), the last enzyme in the sphingomyelin (SM) biosynthetic pathway, uses ceramide and phosphatidylcholine as substrates to produce SM and diacylglycerol (DAG).	Phosphatidylcholines	112-131	spermine synthase	Homo sapiens	0-22
17982138-1	2008	Sphingomyelin synthase (SMS), the last enzyme in the sphingomyelin (SM) biosynthetic pathway, uses ceramide and phosphatidylcholine as substrates to produce SM and diacylglycerol (DAG).	Phosphatidylcholines	112-131	spermine synthase	Homo sapiens	24-27
18042552-1	2008	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	125-144	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
18042552-1	2008	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	125-144	cut-like homeobox 1	Mus musculus	81-84
18042552-1	2008	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	146-148	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
18042552-1	2008	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC).	Phosphatidylcholines	146-148	cut-like homeobox 1	Mus musculus	81-84
18042552-8	2008	When knock-out hepatocytes were infected with an adenovirus expressing CTalpha, apoAI-dependent PC efflux returned partially, whereas cholesterol efflux and ABCA1 levels were not restored to normal levels.	Phosphatidylcholines	96-98	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	71-78
18042552-11	2008	The observations demonstrate that hepatic PC biosynthesis is a key player in maintaining plasma VLDL and HDL, and further underscores the importance of the liver in HDL formation.	Phosphatidylcholines	42-44	CD320 antigen	Mus musculus	96-100
18029352-0	2008	Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	105-124	choline kinase alpha	Mus musculus	63-83
18029352-1	2008	Choline kinase alpha (CK-alpha) is one of two mammalian enzymes that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid, phosphatidylcholine.	Phosphatidylcholines	183-202	choline kinase alpha	Homo sapiens	0-30
18029352-9	2008	Thus, Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine.	Phosphatidylcholines	144-163	choline kinase alpha	Mus musculus	6-10
17662254-5	2008	The "newly formed" phosphatidylcholine is felt to induce alterations in the membrane fluidity, which might favor vesicular fusion with the plasma membrane for the exocytosis of insulin.	Phosphatidylcholines	19-38	insulin	Homo sapiens	177-184
18003621-0	2008	Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.	Phosphatidylcholines	42-61	acyl-CoA synthetase long chain family member 3	Homo sapiens	0-32
18003621-4	2008	In cultured human hepatoma Huh7 cells, ACSL3 is specifically required for incorporation of fatty acids into phosphatidylcholine.	Phosphatidylcholines	108-127	acyl-CoA synthetase long chain family member 3	Homo sapiens	39-44
18156367-9	2008	Characterization of the product of the Aytl2 gene as the phosphatidylcholine reacylating enzyme in RBCs represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein.	Phosphatidylcholines	57-76	lysophosphatidylcholine acyltransferase 1	Homo sapiens	39-44
17890138-4	2008	Our results showed that suppressing phosphatidylcholine-specific phospholipase C in the presence of basic fibroblast growth factor could induce cell neuronal differentiation and the viability of the differentiated cells was obviously increased.	Phosphatidylcholines	36-55	fibroblast growth factor 2	Rattus norvegicus	100-130
17964533-1	2008	Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes.	Phosphatidylcholines	46-66	phospholipase A2 group X	Homo sapiens	0-26
17964533-1	2008	Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes.	Phosphatidylcholines	46-66	phospholipase A2 group X	Homo sapiens	28-33
17964533-1	2008	Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes.	Phosphatidylcholines	68-70	phospholipase A2 group X	Homo sapiens	0-26
17964533-1	2008	Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes.	Phosphatidylcholines	68-70	phospholipase A2 group X	Homo sapiens	28-33
17981627-7	2008	TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes.	Phosphatidylcholines	122-141	tumor necrosis factor	Homo sapiens	0-9
17981627-7	2008	TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes.	Phosphatidylcholines	122-141	interleukin 1 alpha	Homo sapiens	14-23
17981627-8	2008	Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling.	Phosphatidylcholines	50-69	tumor necrosis factor	Homo sapiens	138-147
17981627-8	2008	Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling.	Phosphatidylcholines	50-69	interleukin 1 alpha	Homo sapiens	151-160
18061140-6	2008	In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	222-241	transthyretin	Homo sapiens	38-41
18061140-6	2008	In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	243-245	transthyretin	Homo sapiens	38-41
17627030-2	2007	Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types.	Phosphatidylcholines	64-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-108
17890067-4	2007	SIF containing 5mM sodium taurocholate and 1.25 mM phosphatidylcholine or lysophosphatidylcholine in Leibovitz"s L-15 induced less release of lactate dehydrogenase than the traditional transport medium, HBSS.	Phosphatidylcholines	51-70	immunoglobulin kappa variable 1D-16	Homo sapiens	113-117
18826063-2	2008	The polar choline head groups on immobilized phosphatidylcholine were used for the affinity purification of phospholipase A (PLA).	Phosphatidylcholines	45-64	phospholipase A and acyltransferase 1	Homo sapiens	108-123
18826063-2	2008	The polar choline head groups on immobilized phosphatidylcholine were used for the affinity purification of phospholipase A (PLA).	Phosphatidylcholines	45-64	phospholipase A and acyltransferase 1	Homo sapiens	125-128
18052211-5	2007	In a mixed 70% phosphatidylcholine/30% dilaurin environment, colipase adsorbs to but does not penetrate deeply into the film.	Phosphatidylcholines	15-34	colipase	Homo sapiens	61-69
18221610-1	2007	ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	42-61	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
18221610-1	2007	ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane.	Phosphatidylcholines	42-61	ATP binding cassette subfamily B member 4	Homo sapiens	7-11
17726488-2	2007	ABCB4 is the liver-specific membrane transporter of phosphatidylcholine, a major and exclusive component of mammalian bile.	Phosphatidylcholines	52-71	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
17627030-2	2007	Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types.	Phosphatidylcholines	64-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	110-113
17996202-0	2007	The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover.	Phosphatidylcholines	82-101	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	39-43
18032786-10	2007	Our findings establish that cells can regulate the levels of polyunsaturated fatty acids in phospholipids through iPLA(2)-mediated deacylation of PCs.	Phosphatidylcholines	146-149	phospholipase A2 group VI	Homo sapiens	114-121
18032786-11	2007	Disruption of this regulation increases the proportions of PCs containing polyunsaturated fatty acids and activates the ATR-p53 signalling pathway.	Phosphatidylcholines	59-62	ATR serine/threonine kinase	Homo sapiens	120-123
18032786-11	2007	Disruption of this regulation increases the proportions of PCs containing polyunsaturated fatty acids and activates the ATR-p53 signalling pathway.	Phosphatidylcholines	59-62	tumor protein p53	Homo sapiens	124-127
16996649-5	2007	The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues.	Phosphatidylcholines	113-132	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-20
16996649-5	2007	The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues.	Phosphatidylcholines	134-136	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-20
18032786-0	2007	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.	Phosphatidylcholines	32-52	tumor protein p53	Homo sapiens	127-130
18032786-0	2007	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.	Phosphatidylcholines	32-52	ATR serine/threonine kinase	Homo sapiens	153-156
18032786-7	2007	Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2).	Phosphatidylcholines	66-86	phospholipase A2 group VI	Homo sapiens	226-233
18032786-7	2007	Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2).	Phosphatidylcholines	88-91	phospholipase A2 group VI	Homo sapiens	226-233
18032786-7	2007	Moreover, we identify in cell membranes a significant increase of phosphatidylcholines (PCs) containing chains of polyunsaturated fatty acids and a decrease of PCs containing saturated fatty acids in response to inhibition of iPLA(2).	Phosphatidylcholines	160-163	phospholipase A2 group VI	Homo sapiens	226-233
17996202-4	2007	We further show that disruption of LCA1 caused an enhanced production of glycerophosphorylcholine, a product of phosphatidylcholine (PC) deacylation and that the lysophosphatidic acid acyltransferase SLC1 was not involved in this process.	Phosphatidylcholines	112-131	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	35-39
17996202-4	2007	We further show that disruption of LCA1 caused an enhanced production of glycerophosphorylcholine, a product of phosphatidylcholine (PC) deacylation and that the lysophosphatidic acid acyltransferase SLC1 was not involved in this process.	Phosphatidylcholines	133-135	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	35-39
17974980-10	2007	Wild-type and bax(-/-)bak(-/-) cells showed similar patterns of phosphatidylcholine and protein synthesis inhibition, despite their differences in drug sensitivity.	Phosphatidylcholines	64-83	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	290-309	phospholipase A2 group IIA	Homo sapiens	16-43
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	290-309	phospholipase A2 group IIA	Homo sapiens	45-52
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	290-309	phospholipase A2 group IID	Homo sapiens	96-104
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	290-309	phospholipase A2 group IID	Homo sapiens	150-158
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	311-313	phospholipase A2 group IIA	Homo sapiens	16-43
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	311-313	phospholipase A2 group IIA	Homo sapiens	45-52
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	311-313	phospholipase A2 group IID	Homo sapiens	96-104
17980167-2	2007	Of 10 mammalian secreted phospholipase A(2) (sPLA(2)) enzymes identified to date, group V and X sPLA(2)s, which are two potent plasma membrane-acting sPLA(2)s, are capable of preventing host cells from being infected with adenovirus, and this anti-viral action depends on the conversion of phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) in the host cell membrane.	Phosphatidylcholines	311-313	phospholipase A2 group IID	Homo sapiens	150-158
17804406-1	2007	CTP:phosphocholine cytidylyltransferase (CCTalpha) is a proteolytically sensitive enzyme essential for production of phosphatidylcholine, the major phospholipid of animal cell membranes.	Phosphatidylcholines	117-136	phosphate cytidylyltransferase 1A, choline	Homo sapiens	41-49
17974980-10	2007	Wild-type and bax(-/-)bak(-/-) cells showed similar patterns of phosphatidylcholine and protein synthesis inhibition, despite their differences in drug sensitivity.	Phosphatidylcholines	64-83	BCL2 antagonist/killer 1	Homo sapiens	22-25
17656736-10	2007	Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles.	Phosphatidylcholines	37-56	apolipoprotein A1	Homo sapiens	153-159
17656736-10	2007	Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles.	Phosphatidylcholines	37-56	apolipoprotein A1	Homo sapiens	173-179
17656736-10	2007	Importantly, treatment of cells with phosphatidylcholine-specific phospholipase C, but not sphingomyelinase, concomitantly reduced the binding of (125)I-apoA-I to the HCBS, apoA-I-mediated cholesterol efflux, and the formation of nascent apoA-I-containing particles.	Phosphatidylcholines	37-56	apolipoprotein A1	Homo sapiens	173-179
17497080-2	2007	To study the influence of cholesterol on P-gp in a well defined lipid environment, we reconstituted P-gp in egg phosphatidylcholine (PhC) and PhC/cholesterol proteoliposomes with negligible residual amounts of detergents.	Phosphatidylcholines	133-136	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
17761632-2	2007	We have shown that ABCG1 mediates the efflux of not only cholesterol but also sphingomyelin (SM) and phosphatidylcholine.	Phosphatidylcholines	101-120	ATP-binding cassette sub-family G member 1	Cricetulus griseus	19-24
17914593-1	2007	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
17914593-1	2007	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
17994285-4	2007	Elevation of the lung surfactant phosphatidylcholine (PC) has previously been reported in the Hexb mouse, a model of Sandhoff disease.	Phosphatidylcholines	33-52	hexosaminidase B	Mus musculus	94-98
17994285-4	2007	Elevation of the lung surfactant phosphatidylcholine (PC) has previously been reported in the Hexb mouse, a model of Sandhoff disease.	Phosphatidylcholines	54-56	hexosaminidase B	Mus musculus	94-98
18053412-4	2007	One clone displaying the peptide SVSVGMKPSPRP (designated as PS3-10) bound to PS approximately 4-fold better than its binding to phosphatidylcholine and 18-fold better than to bovine serum albumin in a solid-phase binding assay.	Phosphatidylcholines	129-148	taste 2 receptor member 6 pseudogene	Homo sapiens	61-64
17914593-1	2007	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
17914593-1	2007	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline.	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
17601877-2	2007	Inactivation of the CDP-choline pathway for phosphatidylcholine synthesis allows cells to survive in the absence of Sec14p function through restoration of Golgi vesicular transport capability.	Phosphatidylcholines	44-63	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	116-122
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	72-91	Spo20p	Saccharomyces cerevisiae S288C	16-22
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	72-91	phospholipase D	Saccharomyces cerevisiae S288C	53-59
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	93-95	Spo20p	Saccharomyces cerevisiae S288C	16-22
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	93-95	phospholipase D	Saccharomyces cerevisiae S288C	53-59
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	138-140	Spo20p	Saccharomyces cerevisiae S288C	16-22
17714435-4	2007	The function of Spo20p requires enzymatically active Spo14p, which is a phosphatidylcholine (PC)-specific phospholipase D that hydrolyzes PC to generate phosphatidic acid (PA).	Phosphatidylcholines	138-140	phospholipase D	Saccharomyces cerevisiae S288C	53-59
17701359-8	2007	We demonstrated also that myeloperoxidase is eluted together with pure phosphatidylserine liposomes or liposomes composed of phosphatidylserine and phosphatidylcholine in gel filtration, but not with pure phosphatidylcholine liposomes.	Phosphatidylcholines	148-167	myeloperoxidase	Homo sapiens	26-41
17917852-1	2007	CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis.	Phosphatidylcholines	43-62	cut-like homeobox 1	Rattus norvegicus	0-3
17704541-4	2007	PC-TP, which binds phosphatidylcholine exclusively, is expressed during embryonic development and in several tissues of the adult mouse, including liver.	Phosphatidylcholines	19-38	phosphatidylcholine transfer protein	Mus musculus	0-5
17704541-12	2007	These findings suggest that PC-TP functions as a phosphatidylcholine-sensing molecule that engages in diverse regulatory activities that depend upon the cellular expression of distinct interacting proteins.	Phosphatidylcholines	49-68	phosphatidylcholine transfer protein	Mus musculus	28-33
17626977-1	2007	A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned.	Phosphatidylcholines	98-117	phospholipase A2 group XV	Homo sapiens	8-36
17899539-0	2007	Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells.	Phosphatidylcholines	19-38	Fc gamma receptor IIIa	Homo sapiens	78-82
17899539-2	2007	Our recent findings indicate that CD16 expression on the outer membrane surface of NK cells is correlated with the membrane expression of phosphatidylcholine-specific phospholipase C (PC-PLC).	Phosphatidylcholines	138-157	Fc gamma receptor IIIa	Homo sapiens	34-38
17626977-1	2007	A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned.	Phosphatidylcholines	98-117	phospholipase A2 group XV	Homo sapiens	38-43
17895836-5	2007	The enzyme presented a penetration power value into an egg phosphatidylcholine monomolecular film that was comparable to that of HPL and lower than that of TPL.	Phosphatidylcholines	59-78	pancreatic triacylglycerol lipase	Meleagris gallopavo	156-159
17722906-4	2007	POR-null mice had drastic increases in hepatic lipid content (diacylglycerols, triacylglycerols, phosphatidylcholine, and cholesterol esters) and a specific enrichment in n-7 and n-9 monounsaturated fatty acids (FAs).	Phosphatidylcholines	97-116	cytochrome p450 oxidoreductase	Mus musculus	0-3
18050888-2	2007	Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho).	Phosphatidylcholines	97-116	patatin-like phospholipase domain containing 6	Mus musculus	0-26
17881569-1	2007	The Saccharomyces cerevisiae phosphatidylcholine/phosphatidylinositol transfer protein Sec14p is required for Golgi apparatus-derived vesicular transport through coordinate regulation of phospholipid metabolism.	Phosphatidylcholines	29-48	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	87-93
17881569-3	2007	The essential requirement for SEC14 can be bypassed by inactivation of (i) the CDP-choline pathway for phosphatidylcholine synthesis or (ii) KES1, which encodes an oxysterol binding protein.	Phosphatidylcholines	103-122	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	30-35
17852852-1	2007	OBJECTIVE: Abcb4 (-/-) mice secrete phosphatidylcholine-free, cytotoxic bile and develop chronic cholangitis.	Phosphatidylcholines	36-55	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	11-16
18050888-2	2007	Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho).	Phosphatidylcholines	97-116	patatin-like phospholipase domain containing 6	Mus musculus	28-31
18050888-2	2007	Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho).	Phosphatidylcholines	118-124	patatin-like phospholipase domain containing 6	Mus musculus	0-26
18050888-2	2007	Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho).	Phosphatidylcholines	118-124	patatin-like phospholipase domain containing 6	Mus musculus	28-31
17608770-4	2007	MDR2, the amino acid sequence of which has 86% similarity to that of MDR1, excretes phosphatidylcholine and cholesterol in the presence of bile salts.	Phosphatidylcholines	84-103	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
17616479-10	2007	We measured cellular lipid levels, including SM, ceramide, phosphatidylcholine, and diacylglycerol and found that SMS1 and SMS2 siRNA treatment caused a significant decrease of SM levels (20% and 11%, respectively), compared to control siRNA treatment; SMS1 but not SMS2 siRNA treatment caused a significant increase of ceramide levels (10%).	Phosphatidylcholines	59-78	sphingomyelin synthase 1	Homo sapiens	114-118
17616479-10	2007	We measured cellular lipid levels, including SM, ceramide, phosphatidylcholine, and diacylglycerol and found that SMS1 and SMS2 siRNA treatment caused a significant decrease of SM levels (20% and 11%, respectively), compared to control siRNA treatment; SMS1 but not SMS2 siRNA treatment caused a significant increase of ceramide levels (10%).	Phosphatidylcholines	59-78	sphingomyelin synthase 2	Homo sapiens	123-127
18050660-0	2007	[Depth-dependent investigation of the apolar zone of lipid membranes using a series of fluorescent probes, Me4-BODIPY-8-labeled phosphatidylcholines].	Phosphatidylcholines	128-148	protocadherin beta 17 pseudogene	Homo sapiens	107-110
18050660-1	2007	A series of lipid probes, phosphatidylcholines labeled with Me4-BODIPY-8 (4,4-difluoro-1,3,5,7- tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl) fluorophore attached to the end of an acyl residue at different distances from the polar head, were used as depth-dependent probes for the apolar zone of model membrane systems, large unilamellar vesicles (LUVs).	Phosphatidylcholines	26-46	protocadherin beta 17 pseudogene	Homo sapiens	60-63
17827718-9	2007	In addition, PAF-AH selectively hydrolyzed oxidatively modified phosphatidylcholine.	Phosphatidylcholines	64-83	phospholipase A2 group VII	Homo sapiens	13-19
17608770-4	2007	MDR2, the amino acid sequence of which has 86% similarity to that of MDR1, excretes phosphatidylcholine and cholesterol in the presence of bile salts.	Phosphatidylcholines	84-103	ATP binding cassette subfamily B member 1	Homo sapiens	69-73
17608770-5	2007	ABCA1 transfers phospholipids, preferentially phosphatidylcholine, and cholesterol to lipid-free apoA-I to generate pre-beta-HDL, and ABCG1 excretes phospholipids, preferentially sphingomyelin, and cholesterol.	Phosphatidylcholines	46-65	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
17381426-13	2007	AKR1A4, B1, B7 and B8 catalysed the reduction of aldehydes generated in oxidized C(16:0-20:4) phosphatidylcholine with acyl, plasmenyl or alkyl linkage at the sn-1 position or C(16:0-20:4) phosphatidylglycerol or phosphatidic acid.	Phosphatidylcholines	94-113	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	0-6
17683117-0	2007	PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding.	Phosphatidylcholines	103-122	programmed cell death 1 ligand 2	Mus musculus	0-5
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	273-275	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	16-55
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	273-275	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	151-181
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	273-275	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	183-187
17561512-1	2007	StarD10 is a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes in vitro.	Phosphatidylcholines	74-93	StAR related lipid transfer domain containing 10	Homo sapiens	0-7
17570332-2	2007	In the presence of 30% cholesterol in a noncharged phosphatidylcholine (PC) phospholipid membrane, KA1 (binding affinity constant) and KA2 (insertion affinity constant) derived from a two-step model decreased significantly.	Phosphatidylcholines	51-70	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	99-102
17570332-2	2007	In the presence of 30% cholesterol in a noncharged phosphatidylcholine (PC) phospholipid membrane, KA1 (binding affinity constant) and KA2 (insertion affinity constant) derived from a two-step model decreased significantly.	Phosphatidylcholines	51-70	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	135-138
17591919-2	2007	Recruitment and activation of PKD at the TGN is mediated by the lipid diacylglycerol, a pool of which is generated by sphingomyelin synthase from ceramide and phosphatidylcholine.	Phosphatidylcholines	159-178	protein kinase D1	Homo sapiens	30-33
17614848-1	2007	Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	161-205
17614848-1	2007	Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	207-211
17614848-7	2007	The observed increase in PEMT-specific activity in the residual intestine suggests that extensive enterectomy stimulates the synthesis of phosphatidylcholine by the PEMT-controlled pathway.	Phosphatidylcholines	138-157	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	25-29
17614848-7	2007	The observed increase in PEMT-specific activity in the residual intestine suggests that extensive enterectomy stimulates the synthesis of phosphatidylcholine by the PEMT-controlled pathway.	Phosphatidylcholines	138-157	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	165-169
17729124-1	2007	A new potentially antioxidant compound, spin-labelled lutein (SL-lut), was synthesized and incorporated into egg yolk phosphatidylcholine (EYPC) liposome membrane.	Phosphatidylcholines	118-137	spindlin 1	Homo sapiens	40-44
17595447-1	2007	The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.	Phosphatidylcholines	67-86	phosphatidylethanolamine N-methyltransferase	Mus musculus	4-48
17595447-1	2007	The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.	Phosphatidylcholines	67-86	phosphatidylethanolamine N-methyltransferase	Mus musculus	50-54
17595447-1	2007	The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.	Phosphatidylcholines	88-90	phosphatidylethanolamine N-methyltransferase	Mus musculus	4-48
17595447-1	2007	The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.	Phosphatidylcholines	88-90	phosphatidylethanolamine N-methyltransferase	Mus musculus	50-54
17595447-2	2007	We evaluated whether the PEMT pathway is quantitatively important for biliary PC secretion in mice under various experimental conditions.	Phosphatidylcholines	78-80	phosphatidylethanolamine N-methyltransferase	Mus musculus	25-29
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	85-87	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	16-55
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	85-87	cut-like homeobox 1	Mus musculus	109-112
17595447-4	2007	The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined.	Phosphatidylcholines	85-87	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	151-181
17472963-6	2007	The mutational effect was specific for C1P as all of the cationic mutants of cPLA(2)alpha demonstrated normal basal activity as well as normal affinities for phosphatidylcholine and phosphatidylinositol-4,5-bisphosphate as compared with wild-type cPLA(2)alpha.	Phosphatidylcholines	158-177	phospholipase A2 group IVA	Homo sapiens	77-89
17499576-3	2007	In this study the membrane properties of sphingomyelin and phosphatidylcholine containing elaidic acid (N-E-SM and PEPC) were determined in bilayer membranes with special emphasis on their interaction with cholesterol and participation in ordered domain formation.	Phosphatidylcholines	59-78	peptidase C	Homo sapiens	115-119
17381426-13	2007	AKR1A4, B1, B7 and B8 catalysed the reduction of aldehydes generated in oxidized C(16:0-20:4) phosphatidylcholine with acyl, plasmenyl or alkyl linkage at the sn-1 position or C(16:0-20:4) phosphatidylglycerol or phosphatidic acid.	Phosphatidylcholines	94-113	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	8-21
17513168-5	2007	Plasma PC levels in high-density lipoproteins (HDLs) were higher in male Pemt(-/-) mice than those in females before choline deprivation.	Phosphatidylcholines	7-9	phosphatidylethanolamine N-methyltransferase	Mus musculus	73-77
17531529-7	2007	In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I.	Phosphatidylcholines	137-139	apolipoprotein A1	Homo sapiens	24-30
17531529-2	2007	Although both cell models differed significantly in their cellular lipid composition, a higher apoA-I specific efflux was found for monounsaturated phosphatidylcholine (PC) species together with a decreased contribution of polyunsaturated PC species in both cell types.	Phosphatidylcholines	169-171	apolipoprotein A1	Homo sapiens	95-101
17531529-7	2007	In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I.	Phosphatidylcholines	137-139	ATP binding cassette subfamily A member 1	Homo sapiens	31-36
17531529-7	2007	In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I.	Phosphatidylcholines	137-139	HDL3	Homo sapiens	41-47
17531529-7	2007	In summary, analysis of apoA-I/ABCA1 and HDL(3) mediated lipid efflux by ESI-MS/MS demonstrated a preferential efflux of monounsaturated PC and medium chain SPM to apoA-I.	Phosphatidylcholines	137-139	apolipoprotein A1	Homo sapiens	164-170
17482853-2	2007	We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis.	Phosphatidylcholines	236-238	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	187-190
17482853-2	2007	We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis.	Phosphatidylcholines	236-238	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	146-185
17482853-5	2007	Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology.	Phosphatidylcholines	53-55	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	85-93
17482853-5	2007	Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology.	Phosphatidylcholines	53-55	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	139-147
17523162-2	2007	ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane.	Phosphatidylcholines	40-59	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
17523162-2	2007	ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane.	Phosphatidylcholines	61-63	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
17523162-11	2007	Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin.	Phosphatidylcholines	106-108	EPH receptor A3	Homo sapiens	66-69
17523162-2	2007	ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane.	Phosphatidylcholines	108-110	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
17523162-11	2007	Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin.	Phosphatidylcholines	106-108	ATP binding cassette subfamily B member 4	Homo sapiens	70-75
17613109-1	2007	Cytidine-5"-diphosphocholine (citicoline or CDP-choline) is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	120-139	cut-like homeobox 1	Mus musculus	44-47
17520483-1	2007	Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules.	Phosphatidylcholines	158-160	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-4
17520483-0	2007	Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae.	Phosphatidylcholines	0-19	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	80-114
17520483-1	2007	Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules.	Phosphatidylcholines	158-160	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	24-58
17520483-0	2007	Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae.	Phosphatidylcholines	0-19	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	115-119
17520483-1	2007	Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules.	Phosphatidylcholines	137-156	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-4
17520483-2	2007	In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered.	Phosphatidylcholines	73-75	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	41-45
17520483-1	2007	Gut2, the mitochondrial glycerol-3-phosphate dehydrogenase, was previously shown to become preferentially labelled with photoactivatable phosphatidylcholine (PC), pointing to a functional relation between these molecules.	Phosphatidylcholines	137-156	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	24-58
17520483-2	2007	In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered.	Phosphatidylcholines	106-108	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	41-45
17520483-2	2007	In the present study we analyzed whether Gut2 functioning depends on the PC content of yeast cells, using PC biosynthetic mutants in which the PC content was lowered.	Phosphatidylcholines	106-108	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	41-45
17520483-3	2007	PC depletion was found to reduce growth on glycerol and to increase glycerol excretion, both indicating that PC is needed for optimal Gut2 functioning in vivo.	Phosphatidylcholines	0-2	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	134-138
17520483-3	2007	PC depletion was found to reduce growth on glycerol and to increase glycerol excretion, both indicating that PC is needed for optimal Gut2 functioning in vivo.	Phosphatidylcholines	109-111	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	134-138
17520483-4	2007	Using several in vitro approaches the nature of the dependence of Gut2 functioning on cellular PC contents was investigated.	Phosphatidylcholines	95-97	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	66-70
17520483-6	2007	The in vivo effects are more likely an indirect result of PC depletion-induced changes in the cellular context in which Gut2 functions, that are not manifested in the in vitro systems used.	Phosphatidylcholines	58-60	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	120-124
17218027-1	2007	We previously reported that vasoactive intestinal peptide (VIP) promoted synthesis of phosphatidylcholine (PC) in alveolar type II (ATII) cells.	Phosphatidylcholines	86-105	vasoactive intestinal peptide	Homo sapiens	59-62
17462583-12	2007	These results are in agreement with previously reported DSC and (2)H NMR spectroscopy study of the interaction of the L(24) and structurally related peptides with phosphatidylcholine bilayers.	Phosphatidylcholines	163-182	immunoglobulin kappa variable 1D-8	Homo sapiens	118-123
17409096-8	2007	These results suggest that the function of ABCA1 could be divided into two steps: (i) a flopping step to move phosphatidylcholine and cholesterol from the inner to outer leaflet of the plasma membrane, where cholesterol becomes available to cold MbetaCD extraction, and (ii) a loading step to load phosphatidylcholine and cholesterol onto apoA-I to generate HDL.	Phosphatidylcholines	110-129	phospholipid-transporting ATPase ABCA1	Cricetulus griseus	43-48
17409096-8	2007	These results suggest that the function of ABCA1 could be divided into two steps: (i) a flopping step to move phosphatidylcholine and cholesterol from the inner to outer leaflet of the plasma membrane, where cholesterol becomes available to cold MbetaCD extraction, and (ii) a loading step to load phosphatidylcholine and cholesterol onto apoA-I to generate HDL.	Phosphatidylcholines	298-317	phospholipid-transporting ATPase ABCA1	Cricetulus griseus	43-48
17325006-1	2007	Sec14p promotes the energy-independent transfer of either phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between lipid bilayers in vitro and represents the major PtdIns/PtdCho transfer protein in the budding yeast Saccharomyces cerevisiae.	Phosphatidylcholines	91-110	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-6
17325006-2	2007	Herein, we employ multi-frequency high-field electron paramagnetic resonance (EPR) to analyze the electrostatic and hydrogen-bonding microenvironments for series of doxyl-labeled PtdCho molecules bound by Sec14p in a soluble protein-PtdCho complex.	Phosphatidylcholines	179-185	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	205-211
17325006-6	2007	Partially resolved 130-GHz EPR spectra from n-doxyl-PtdCho bound to Sec14p were analyzed using this two-component model and allowed quantification of two parameters.	Phosphatidylcholines	52-58	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	68-74
17490911-3	2007	Mammalian phosphatidylinositol transfer proteins, PITPalpha and PITPbeta are paralogs that share 77% sequence identity and contain a hydrophobic cavity that can sequester either phosphatidylinositol or phosphatidylcholine.	Phosphatidylcholines	202-221	phosphatidylinositol transfer protein alpha	Homo sapiens	50-59
17490911-3	2007	Mammalian phosphatidylinositol transfer proteins, PITPalpha and PITPbeta are paralogs that share 77% sequence identity and contain a hydrophobic cavity that can sequester either phosphatidylinositol or phosphatidylcholine.	Phosphatidylcholines	202-221	phosphatidylinositol transfer protein beta	Homo sapiens	64-72
17499021-1	2007	Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro.	Phosphatidylcholines	111-130	phosphatidylcholine transfer protein	Mus musculus	0-36
17499021-1	2007	Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro.	Phosphatidylcholines	111-130	phosphatidylcholine transfer protein	Mus musculus	38-43
17499021-4	2007	Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypothesis that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism.	Phosphatidylcholines	281-300	phosphatidylcholine transfer protein	Mus musculus	50-54
17613168-3	2007	A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	156-175	phosphatidylethanolamine N-methyltransferase	Homo sapiens	189-233
17613168-3	2007	A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver.	Phosphatidylcholines	156-175	phosphatidylethanolamine N-methyltransferase	Homo sapiens	235-239
17430887-6	2007	We measured the binding of catalytically competent mouse PLC-zeta to phospholipid vesicles: for 2:1 phosphatidylcholine/phosphatidylserine (PC/PS) vesicles, the molar partition coefficient, K, is too weak to be of physiological significance.	Phosphatidylcholines	100-119	phospholipase C, zeta 1	Mus musculus	57-65
17405772-5	2007	Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD).	Phosphatidylcholines	135-154	phosphatase and tensin homolog	Homo sapiens	10-14
17405772-5	2007	Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD).	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-205
17405772-5	2007	Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD).	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	207-210
17218027-1	2007	We previously reported that vasoactive intestinal peptide (VIP) promoted synthesis of phosphatidylcholine (PC) in alveolar type II (ATII) cells.	Phosphatidylcholines	107-109	vasoactive intestinal peptide	Homo sapiens	59-62
17218027-3	2007	In this work, we investigated the intracellular signal transduction pathway for VIP promoted synthesis of PC, the major lipid component of pulmonary surfactant (PS), by using an antagonist of VIP receptors, inhibitor of protein kinase C (PKC) and antisense oligonucleotides (AS-ODN) for c-fos oncogene.	Phosphatidylcholines	106-108	vasoactive intestinal peptide	Homo sapiens	80-83
17218027-6	2007	These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC.	Phosphatidylcholines	161-163	vasoactive intestinal peptide	Homo sapiens	32-35
17218027-6	2007	These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC.	Phosphatidylcholines	161-163	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
17218027-6	2007	These results demonstrated that VIP receptors, PKC and c-Fos protein played important roles in the signaling pathway through which VIP promoted the synthesis of PC.	Phosphatidylcholines	161-163	vasoactive intestinal peptide	Homo sapiens	131-134
17272829-5	2007	HDL from hA-ITg SR-BI-/- mice was enriched in sphingomyelin (SM), relative to phosphatidylcholine, and had less associated [35S]LCAT radiolabel and endogenous LCAT activity compared with HDL from hA-ITg mice.	Phosphatidylcholines	78-97	scavenger receptor class B member 1	Homo sapiens	16-21
17465727-1	2007	Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline.	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-25
17465727-1	2007	Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline.	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
17158358-2	2007	In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model.	Phosphatidylcholines	42-61	tumor necrosis factor	Rattus norvegicus	130-139
17158358-2	2007	In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model.	Phosphatidylcholines	42-61	interleukin 1 beta	Rattus norvegicus	144-152
17391797-2	2007	A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	165-184	phosphatidylethanolamine N-methyltransferase	Homo sapiens	52-96
17391797-2	2007	A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	165-184	phosphatidylethanolamine N-methyltransferase	Homo sapiens	98-102
17283071-2	2007	Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	51-70	phosphatidylethanolamine N-methyltransferase	Mus musculus	146-190
17344474-1	2007	Molecular dynamics simulations coupled with functional analyses of the major yeast phosphatidylinositol/phosphatidylcholine transfer protein Sec14p identify structural elements involved in regulating the ability of Sec14p to execute phospholipid exchange.	Phosphatidylcholines	104-123	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	141-147
17344474-1	2007	Molecular dynamics simulations coupled with functional analyses of the major yeast phosphatidylinositol/phosphatidylcholine transfer protein Sec14p identify structural elements involved in regulating the ability of Sec14p to execute phospholipid exchange.	Phosphatidylcholines	104-123	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	215-221
17169434-0	2007	A colorimetric assay for measuring phospholipase A2 degradation of phosphatidylcholine at physiological pH.	Phosphatidylcholines	67-86	phospholipase A2 group IB	Homo sapiens	35-51
17367165-7	2007	For the cPLA2alpha C2 domain, the target lipid phosphatidylcholine (PC) appears to be sufficient to drive membrane targeting to an internal membrane mimic at physiological Ca2+ levels, although the results do not rule out a second, unknown target molecule.	Phosphatidylcholines	47-66	phospholipase A2 group IVA	Homo sapiens	8-18
17367165-7	2007	For the cPLA2alpha C2 domain, the target lipid phosphatidylcholine (PC) appears to be sufficient to drive membrane targeting to an internal membrane mimic at physiological Ca2+ levels, although the results do not rule out a second, unknown target molecule.	Phosphatidylcholines	68-70	phospholipase A2 group IVA	Homo sapiens	8-18
17311918-1	2007	Snake presynaptic phospholipase A2 neurotoxins (SPANs) bind to the presynaptic membrane and hydrolyze phosphatidylcholine with generation of lysophosphatidylcholine (LysoPC) and fatty acid (FA).	Phosphatidylcholines	102-121	phospholipase A2 group IB	Homo sapiens	18-34
17388516-1	2007	Achatin-I (Gly1-d-Phe2-Ala3-Asp4), known as a neuropeptide containing a d-amino acid, binds to the surface of a zwitterionic phosphatidylcholine (PC) membrane only when the peptide N-terminal amino group is in the ionized state, NH3+ (Kimura, T.; Okamura, E.; Matubayasi, N.; Asami, K.; Nakahara, M. Biophys.	Phosphatidylcholines	125-144	threonine aldolase 1, pseudogene	Homo sapiens	11-15
17388516-1	2007	Achatin-I (Gly1-d-Phe2-Ala3-Asp4), known as a neuropeptide containing a d-amino acid, binds to the surface of a zwitterionic phosphatidylcholine (PC) membrane only when the peptide N-terminal amino group is in the ionized state, NH3+ (Kimura, T.; Okamura, E.; Matubayasi, N.; Asami, K.; Nakahara, M. Biophys.	Phosphatidylcholines	125-144	napsin A aspartic peptidase	Homo sapiens	28-32
17283071-2	2007	Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	51-70	phosphatidylethanolamine N-methyltransferase	Mus musculus	192-196
17349923-0	2007	Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation.	Phosphatidylcholines	23-42	interferon gamma	Homo sapiens	89-105
17292664-2	2007	Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	64-83	phosphatidylethanolamine N-methyltransferase	Mus musculus	92-136
17292664-2	2007	Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	64-83	phosphatidylethanolamine N-methyltransferase	Mus musculus	138-142
17066268-1	2007	The bovine seminal plasma protein PDC-109 modulates the maturation of bull sperm cells by removing lipids, mainly phosphatidylcholine and cholesterol, from their cellular membrane.	Phosphatidylcholines	114-133	seminal plasma protein PDC-109	Bos taurus	11-41
17066268-5	2007	From these cells, PDC-109 extracted phosphatidylcholine and sphingomyelin that contained an enrichment of mono- and di-unsaturated fatty acids as well as short-chain and lyso-phosphatidylcholine species.	Phosphatidylcholines	36-55	seminal plasma protein PDC-109	Bos taurus	18-25
17258706-4	2007	Mitochondrial phosphatidylethanolamine and phosphatidylcholine from Gpat1-/- liver contained 21% and 67% more arachidonate, respectively, than wildtype controls, and higher amounts of 4-hydroxynonenal, a product of arachidonate peroxidation.	Phosphatidylcholines	43-62	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	68-73
17349923-2	2007	Phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes.	Phosphatidylcholines	50-69	surfactant protein C	Homo sapiens	71-73
17148553-4	2007	In liposomes containing synthetic phosphatidylcholines (PCs), sPLA(2)X showed no clear selectivity among the various sn-2 unsaturated fatty acids.	Phosphatidylcholines	56-59	phospholipase A2 group X	Homo sapiens	62-70
17213183-3	2007	We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and enhanced activities of the choline cytidylyltransferase (CCT) and cholinephosphotransferase enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis.	Phosphatidylcholines	112-131	X-box binding protein 1	Homo sapiens	26-31
17213183-3	2007	We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and enhanced activities of the choline cytidylyltransferase (CCT) and cholinephosphotransferase enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis.	Phosphatidylcholines	133-139	X-box binding protein 1	Homo sapiens	26-31
17178780-0	2007	The Psa fimbriae of Yersinia pestis interact with phosphatidylcholine on alveolar epithelial cells and pulmonary surfactant.	Phosphatidylcholines	50-69	aminopeptidase puromycin sensitive	Homo sapiens	4-7
17178780-4	2007	The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays.	Phosphatidylcholines	35-54	aminopeptidase puromycin sensitive	Homo sapiens	4-7
17178780-4	2007	The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays.	Phosphatidylcholines	56-58	aminopeptidase puromycin sensitive	Homo sapiens	4-7
17178780-4	2007	The Psa receptor was identified as phosphatidylcholine (PC) by TLC using alkali treatment, molybdenum blue staining, and Psa overlays.	Phosphatidylcholines	56-58	aminopeptidase puromycin sensitive	Homo sapiens	121-124
17178780-5	2007	The Psa fimbriae bound to PC in a dose-dependent manner, and binding was inhibited by phosphorylcholine (ChoP) and choline.	Phosphatidylcholines	26-28	aminopeptidase puromycin sensitive	Homo sapiens	4-7
17142808-7	2007	Mass spectrometry measurement of &gt;300 phospholipids in lung tissue taken from Abca3(-/-) mice showed a dramatic reduction of phosphatidylglycerol (PG) levels as well as selective reductions in phosphatidylcholine species containing short acyl chains.	Phosphatidylcholines	196-215	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	81-86
17321580-3	2007	Phosphatidylcholine, the principal component of pulmonary surfactant that maintains small airway patency, is hydrolyzed by sPLA(2).	Phosphatidylcholines	0-19	phospholipase A2 group IIA	Homo sapiens	123-130
17321580-11	2007	The combined actions of sPLA(2) and lysophospholipase produced dose-dependent and time-dependent losses of surfactant function, concomitant with hydrolysis of phosphatidylcholine and lysophosphatidylcholine.	Phosphatidylcholines	159-178	phospholipase A2 group IIA	Homo sapiens	24-53
17207856-4	2007	VH12 anti-phosphatidylcholine (PtC) IgH transgenic mice provide a model for the induced differentiation of B-1 cells.	Phosphatidylcholines	10-29	immunoglobulin heavy chain complex	Mus musculus	36-39
17267394-5	2007	TLC and electrospray ionization mass spectrometry analyses of lipids in the pulmonary interstitium showed that phosphatidylcholine and phosphatidylglycerol, which contain palmitic acid and are abundant in normal surfactant lipids, were dramatically decreased in Abca3(-/-) lung.	Phosphatidylcholines	111-130	ATP binding cassette subfamily A member 3	Homo sapiens	262-267
17213195-6	2007	In contrast, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) protein, a key control point in phosphatidylcholine biosynthesis, increased because of stabilization of protein turnover rather than transcriptional activation.	Phosphatidylcholines	102-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	13-58
17213195-6	2007	In contrast, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) protein, a key control point in phosphatidylcholine biosynthesis, increased because of stabilization of protein turnover rather than transcriptional activation.	Phosphatidylcholines	102-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	60-68
17344490-2	2007	Previously, we showed an association between elevated plasma homocysteine, reduced ratios of S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) and of phosphatidylcholine to phosphatidylethanolamine, and phospholipid malabsorption in children with CF.	Phosphatidylcholines	157-176	acyl-CoA synthetase medium chain family member 3	Homo sapiens	145-148
16731034-2	2007	This concept is illustrated in this review by summarizing recent evidence on Nte1p, a yeast endoplasmic reticulum resident phospholipase B that deacylates PtdCho producing intracellular glycerophosphocholine.	Phosphatidylcholines	155-161	lysophospholipase	Saccharomyces cerevisiae S288C	77-82
17260960-4	2007	In Langmuir monolayer studies high-activity (HA) and low-activity (LA) forms of PLTP associated with fluid phosphatidylcholine monolayers spread at the air/buffer interphase.	Phosphatidylcholines	107-126	phospholipid transfer protein	Homo sapiens	80-84
17204250-4	2007	Treatment with TNF-alpha antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA2 IIA protein expression, PLA2 activity and significantly restored phosphatidylcholine levels after tMCAO.	Phosphatidylcholines	177-196	tumor necrosis factor	Rattus norvegicus	15-24
17179149-1	2007	5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes.	Phosphatidylcholines	148-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-130
17179149-1	2007	5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes.	Phosphatidylcholines	148-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	132-136
17179149-1	2007	5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes.	Phosphatidylcholines	169-171	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-130
17179149-1	2007	5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes.	Phosphatidylcholines	169-171	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	132-136
17179149-2	2007	In all nucleated mammalian cells, PC is synthesized from choline via the Kennedy (CDP-choline) pathway.	Phosphatidylcholines	34-36	cut like homeobox 1	Homo sapiens	82-85
17179149-3	2007	The purpose of our study was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to elucidate the mechanism(s) by which AMPK inhibits hepatic PC synthesis.	Phosphatidylcholines	167-169	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	61-65
17179149-3	2007	The purpose of our study was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to elucidate the mechanism(s) by which AMPK inhibits hepatic PC synthesis.	Phosphatidylcholines	167-169	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	145-149
17158102-5	2007	Upon overexpression in COS-7 cells, one protein, named rat LRAT-like protein (RLP)-1, catalyzed transfer of a radioactive acyl group from phosphatidylcholine (PC) to PE, resulting in the formation of radioactive NAPE.	Phosphatidylcholines	138-157	lecithin retinol acyltransferase	Rattus norvegicus	59-63
17158102-5	2007	Upon overexpression in COS-7 cells, one protein, named rat LRAT-like protein (RLP)-1, catalyzed transfer of a radioactive acyl group from phosphatidylcholine (PC) to PE, resulting in the formation of radioactive NAPE.	Phosphatidylcholines	159-161	lecithin retinol acyltransferase	Rattus norvegicus	59-63
16963094-2	2007	In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline.	Phosphatidylcholines	124-143	patatin like phospholipase domain containing 6	Homo sapiens	35-38
16963094-2	2007	In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline.	Phosphatidylcholines	124-143	phospholamban	Homo sapiens	62-77
16963094-2	2007	In yeast and mammalian cell lines, NTE has been shown to have phospholipase B (PLB) activity which deacylates intracellular phosphatidylcholine to glycerophosphocholine (GroPCho) and can be detected by metabolic labeling with [(14)C]choline.	Phosphatidylcholines	124-143	phospholamban	Homo sapiens	79-82
17189248-10	2007	In addition, the T455A mutation caused a 44% decrease in the amount of human CTP synthetase 1 that was phosphorylated in S. cerevisiae cells, and this was accompanied by a 2.5-fold increase in the cellular concentration of CTP and a 1.5-fold increase in the choline-dependent synthesis of phosphatidylcholine.	Phosphatidylcholines	289-308	CTP synthase 1	Homo sapiens	77-93
17184749-1	2007	The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain.	Phosphatidylcholines	55-74	cut-like homeobox 1	Rattus norvegicus	174-177
17184749-1	2007	The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain.	Phosphatidylcholines	76-82	cut-like homeobox 1	Rattus norvegicus	174-177
17184936-3	2007	It has been suggested that NTE is responsible for phosphatidylcholine homeostasis, although its role in neuropathy induction remains unclear.	Phosphatidylcholines	50-69	patatin like phospholipase domain containing 6	Bos taurus	27-30
17156888-5	2007	RESULTS: We observed that ethanol feeding resulted in decreased phosphatidylcholine (PC) production by a PEMT-catalyzed reaction.	Phosphatidylcholines	64-83	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	105-109
17138935-2	2007	METHODS AND RESULTS: Cultured human aortic endothelial cells were stimulated with tumor necrosis factor (TNF)-alpha in the presence of human recombinant apoE3 solubilized in dimyristoyl phosphatidylcholine liposomes.	Phosphatidylcholines	186-205	tumor necrosis factor	Homo sapiens	82-115
17138935-2	2007	METHODS AND RESULTS: Cultured human aortic endothelial cells were stimulated with tumor necrosis factor (TNF)-alpha in the presence of human recombinant apoE3 solubilized in dimyristoyl phosphatidylcholine liposomes.	Phosphatidylcholines	186-205	apolipoprotein E	Homo sapiens	153-158
17156888-5	2007	RESULTS: We observed that ethanol feeding resulted in decreased phosphatidylcholine (PC) production by a PEMT-catalyzed reaction.	Phosphatidylcholines	85-87	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	105-109
17093292-1	2007	Basic polysaccharide strongly inhibited the hydrolysis of trioleoylglycerol (TO) emulsified with phosphatidylcholine and taurocholate by either pancreatic lipase or carboxylester lipase.	Phosphatidylcholines	97-116	lipase G, endothelial type	Rattus norvegicus	155-161
17237796-3	2007	Here we describe the structure of CETP at 2.2-A resolution, revealing a 60-A-long tunnel filled with two hydrophobic cholesteryl esters and plugged by an amphiphilic phosphatidylcholine at each end.	Phosphatidylcholines	166-185	cholesteryl ester transfer protein	Homo sapiens	34-38
17126953-3	2007	On the other hand, phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes.	Phosphatidylcholines	69-88	surfactant protein C	Homo sapiens	90-92
17020537-9	2007	Hsp22 binds more strongly to vesicles made of lipids containing a phosphatidic acid, phosphatidylinositol or phosphatidylserine headgroup (known to be present in the inner leaflet of plasma membrane) compared with lipid vesicles made of a phosphatidylcholine head-group alone.	Phosphatidylcholines	239-258	heat shock protein family B (small) member 8	Homo sapiens	0-5
17184757-1	2007	Neuropathy target esterase (NTE) is a membrane protein present in various tissues whose physiological function has been recently suggested to be the maintenance of phosphatidylcholine homeostasis.	Phosphatidylcholines	164-183	patatin like phospholipase domain containing 6	Bos taurus	0-26
17184757-1	2007	Neuropathy target esterase (NTE) is a membrane protein present in various tissues whose physiological function has been recently suggested to be the maintenance of phosphatidylcholine homeostasis.	Phosphatidylcholines	164-183	patatin like phospholipase domain containing 6	Bos taurus	28-31
17245604-1	2007	Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-52
17245604-1	2007	Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
17114808-2	2007	Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, acts by transferring an acyl group from the sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	159-178	lecithin retinol acyltransferase	Homo sapiens	0-32
17114808-2	2007	Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, acts by transferring an acyl group from the sn-1 position of phosphatidylcholine to retinol.	Phosphatidylcholines	159-178	lecithin retinol acyltransferase	Homo sapiens	34-38
17209172-4	2007	The available evidence indicates that the quantitatively most important pathways for S-adenosylmethionine-dependent transmethylation in mammals are the syntheses of creatine by guanidinoacetate methyltransferase, of phosphatidylcholine by phosphatidylethanolamine methyltransferase, and of sarcosine by glycine N-methyltransferase.	Phosphatidylcholines	216-235	glycine N-methyltransferase	Homo sapiens	303-330
16554055-6	2007	However, the apoA-I secreted by PLTP-KO hepatocytes contained less choline PL, differing also in phosphatidylcholine/sphingomyelin ratio and fatty acyl species composition when compared to apoA-I from WT hepatocytes.	Phosphatidylcholines	97-116	apolipoprotein A-I	Mus musculus	13-19
17038637-4	2007	METHODS AND RESULTS: Among inhibitors specific to PKC activators, phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609 limited apoCIII-induced PKC alpha activation and THP-1 cell adhesion.	Phosphatidylcholines	66-85	apolipoprotein C3	Homo sapiens	143-150
17038637-4	2007	METHODS AND RESULTS: Among inhibitors specific to PKC activators, phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609 limited apoCIII-induced PKC alpha activation and THP-1 cell adhesion.	Phosphatidylcholines	66-85	protein kinase C alpha	Homo sapiens	159-168
16554055-6	2007	However, the apoA-I secreted by PLTP-KO hepatocytes contained less choline PL, differing also in phosphatidylcholine/sphingomyelin ratio and fatty acyl species composition when compared to apoA-I from WT hepatocytes.	Phosphatidylcholines	97-116	phospholipid transfer protein	Mus musculus	32-36
17174597-0	2007	Phosphatidylcholine transfer activity of yeast Sec14p is not essential for its function in vivo.	Phosphatidylcholines	0-19	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	47-53
17174597-1	2007	Yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, Sec14p, is essential for protein transport from the Golgi apparatus and for the cell viability.	Phosphatidylcholines	32-51	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	75-81
17174597-5	2007	Thus, in vitro PC transfer ability of Sec14p is not required for its essential function(s) in living cells, however, yeast cells having PC transfer deficient Sec14p(D115G) as a sole Sec14p display regulatory abnormalities, including increased phospholipase D mediated PC turnover.	Phosphatidylcholines	15-17	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	38-44
17197234-3	2007	In contrast to PtdCho, which was readily hydrolyzed by group V and X sPLA(2)s, and to a lesser extent by group IIA sPLA(2), the minor ethanolamine, inositol and serine glycerophospholipids exhibited marked resistance to hydrolysis by all three sPLA(2)s.	Phosphatidylcholines	15-21	phospholipase A2 group IID	Homo sapiens	69-77
17233594-1	2007	Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival.	Phosphatidylcholines	86-105	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-43
17197234-3	2007	In contrast to PtdCho, which was readily hydrolyzed by group V and X sPLA(2)s, and to a lesser extent by group IIA sPLA(2), the minor ethanolamine, inositol and serine glycerophospholipids exhibited marked resistance to hydrolysis by all three sPLA(2)s.	Phosphatidylcholines	15-21	phospholipase A2 group IIA	Homo sapiens	69-75
17233594-1	2007	Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival.	Phosphatidylcholines	86-105	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-60
18176897-2	2007	Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively.	Phosphatidylcholines	107-126	synuclein alpha	Rattus norvegicus	24-27
17436686-3	2007	LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids.	Phosphatidylcholines	90-109	selectin E	Homo sapiens	26-36
18176897-2	2007	Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively.	Phosphatidylcholines	128-130	synuclein alpha	Rattus norvegicus	24-27
17169600-5	2007	Ghrelin appeared to activate extracellular signal-regulated kinases 1/2 through a calcium-independent novel protein kinase C isoform which may utilize diacylglycerol derived from hydrolysis of phosphatidylcholine rather than from phosphatidylinositol.	Phosphatidylcholines	193-212	mitogen-activated protein kinase 3	Homo sapiens	29-71
17273143-1	2007	The ABCB4 gene codes for a protein involved in the transport of phosphatidylcholine across the canalicular membrane of the hepatocyte.	Phosphatidylcholines	64-83	ATP binding cassette subfamily B member 4	Homo sapiens	4-9
17176081-1	2006	A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC).	Phosphatidylcholines	176-195	proopiomelanocortin	Homo sapiens	29-43
17210739-1	2007	Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to cellular lipid metabolism.	Phosphatidylcholines	78-97	sphingomyelin synthase 2	Rattus norvegicus	0-24
17210739-1	2007	Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to cellular lipid metabolism.	Phosphatidylcholines	78-97	sphingomyelin synthase 2	Rattus norvegicus	26-30
17046062-3	2007	Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%.	Phosphatidylcholines	123-142	phospholipase A2 group VI	Homo sapiens	20-25
17046062-3	2007	Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%.	Phosphatidylcholines	144-150	phospholipase A2 group VI	Homo sapiens	20-25
17046062-3	2007	Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 microM) decreased the expression of 14:0-16:0 phosphatidylcholine (PtdCho) 15% and increased 18:0-18:1-PtdCho expression 15%.	Phosphatidylcholines	180-186	phospholipase A2 group VI	Homo sapiens	20-25
18084901-10	2007	The phospholipase A2 activity plays an important role in lung surfactant homeostasis and is responsible for the bulk of the degradation of internalized phosphatidylcholine and its resynthesis by the reacylation pathway.	Phosphatidylcholines	152-171	phospholipase A2 group IB	Homo sapiens	4-20
17176081-1	2006	A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC).	Phosphatidylcholines	197-199	proopiomelanocortin	Homo sapiens	29-43
17046831-6	2006	Reconstituted HDL composed mainly of apolipoprotein A-I and phosphatidylcholine mimicked the SR-BI-sensitive part of HDL-induced actions.	Phosphatidylcholines	60-79	scavenger receptor class B member 1	Homo sapiens	93-98
17082194-5	2006	An affinity-purified tafazzin construct, tagged with the maltose-binding protein, catalyzed both forward and reverse transacylations between cardiolipin and phosphatidylcholine, but was unable to utilize CoA or acyl-CoA as substrates.	Phosphatidylcholines	157-176	Tafazzin	Drosophila melanogaster	21-29
17082194-6	2006	Whereas tafazzin supported transacylations between various phospholipid-lysophospholipid pairs, it showed the highest rate for the phosphatidylcholine-cardiolipin transacylation.	Phosphatidylcholines	131-150	Tafazzin	Drosophila melanogaster	8-16
17082194-8	2006	The data show that Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine.	Phosphatidylcholines	147-166	Tafazzin	Drosophila melanogaster	30-38
17077289-2	2006	Among sPLA2s, the human group X (hGX) enzyme has the highest catalytic activity toward phosphatidylcholine, one of the major phospholipid species of cell membranes and low-density lipoprotein (LDL).	Phosphatidylcholines	87-106	phospholipase A2 group IID	Homo sapiens	6-12
17132109-3	2006	The aim of this study was to investigate whether methionine, its precursors or metabolites [phosphatidylcholine, choline, betaine, S-adenosylmethionine (SAM)] have a modulating effect on tumor necrosis factor alpha (TNF-alpha) production by endotoxin-stimulated human mononuclear leukocytes and whether SAM-dependent polyamines (spermidine, spermine) are mediators of SAM-induced inhibition of TNF-alpha synthesis.	Phosphatidylcholines	92-111	tumor necrosis factor	Homo sapiens	187-214
16824732-6	2006	Vesicles of phosphatidylcholine (PtdCho) stimulated only twofold PtdIns(3,4,5)P(3) 5-phosphatase activity of SHIP2.	Phosphatidylcholines	12-31	inositol polyphosphate phosphatase like 1	Homo sapiens	109-114
16824732-6	2006	Vesicles of phosphatidylcholine (PtdCho) stimulated only twofold PtdIns(3,4,5)P(3) 5-phosphatase activity of SHIP2.	Phosphatidylcholines	33-39	inositol polyphosphate phosphatase like 1	Homo sapiens	109-114
17121526-4	2006	Plasma PLTP activity was determined as the transfer of radiolabelled phosphatidylcholine from small unilamellar phosphatidylcholine vesicles to ultracentrifugally isolated HDL.	Phosphatidylcholines	69-88	phospholipid transfer protein	Homo sapiens	7-11
17121526-4	2006	Plasma PLTP activity was determined as the transfer of radiolabelled phosphatidylcholine from small unilamellar phosphatidylcholine vesicles to ultracentrifugally isolated HDL.	Phosphatidylcholines	112-131	phospholipid transfer protein	Homo sapiens	7-11
17096689-3	2006	Interestingly, these recombinant proteins were able to reduce H2O2, cumene hydroperoxide, phosphatidylcholine and linoleic acid hydroperoxides using thioredoxin but not glutathione or NADPH as an electron donor.	Phosphatidylcholines	90-109	thioredoxin	Homo sapiens	149-160
17008322-4	2006	This severe pulmonary defect in sPLA2-V Tg mice was attributable to marked reduction of the lung surfactant phospholipids, phosphatidylcholine and phosphatidylglycerol.	Phosphatidylcholines	123-142	phospholipase A2, group X	Mus musculus	32-37
17116711-1	2006	Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	cut-like homeobox 1	Rattus norvegicus	98-101
17116711-1	2006	Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	169-213
17116711-1	2006	Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	215-219
17432083-9	2006	Phosphatidylcholine treatment decreased the leukocyte rolling and sticking, preserved the FCD and improved the RBCV The mast cell degranulation and MPO activity diminished significantly in the muscle layer.	Phosphatidylcholines	0-19	myeloperoxidase	Rattus norvegicus	148-151
17005997-7	2006	TG-lipase was able to hydrolyze the major phospholipid components of the lipid droplets, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	89-108	uncharacterized protein	Drosophila melanogaster	0-9
17189343-7	2006	PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine.	Phosphatidylcholines	219-238	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	81-86
17189343-7	2006	PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine.	Phosphatidylcholines	219-238	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	81-86
16997918-5	2006	Herein, we describe the application of EPR spectroscopy to probe the local dynamics and the electrostatic microenvironment of phosphatidylcholine (PtdCho) bound by Sec14p in a soluble protein-PtdCho complex.	Phosphatidylcholines	126-145	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	164-170
17077504-1	2006	Sec14p is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the budding yeast Saccharomyces cerevisiae and is the founding member of a large eukaryotic protein superfamily.	Phosphatidylcholines	50-69	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-6
17087498-1	2006	Recent publications described the formation of millimeter-length fibers by diverse lipid-binding proteins (e.g., histone H1, cytochrome c, indolicidin, and endostatin) when they are mixed with 80:20 phosphatidylcholine/phosphatidylserine vesicles.	Phosphatidylcholines	199-218	collagen type XVIII alpha 1 chain	Homo sapiens	156-166
17046758-4	2006	Consistent with the structure-based predictions, functional studies demonstrated that Arg120His PC-TP was inactive, suggesting that this mutation contributes to the deficiencies in phosphatidylcholine metabolism observed in NZO mice.	Phosphatidylcholines	181-200	phosphatidylcholine transfer protein	Mus musculus	96-101
17030901-1	2006	We have previously provided evidence suggesting that phosphatidic acid, possibly derived from the hydrolysis of phosphatidylcholine by phospholipase D (PLD), is involved in platelet-derived growth factor (PDGF)-mediated increases in extracellular signal-regulated kinase (ERK) activity and DNA synthesis in rat hepatic stellate cells (HSC), the primary fibrogenic cells of the liver.	Phosphatidylcholines	112-131	Eph receptor B1	Rattus norvegicus	233-270
16807087-1	2006	Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme.	Phosphatidylcholines	182-201	phospholipase A2 group VII	Homo sapiens	7-55
16807087-1	2006	Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme.	Phosphatidylcholines	182-201	phospholipase A2 group VII	Homo sapiens	57-63
16807087-1	2006	Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme.	Phosphatidylcholines	182-201	phospholipase A2 group VII	Homo sapiens	97-105
17042754-4	2006	Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals.	Phosphatidylcholines	0-19	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	45-49
17042754-4	2006	Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals.	Phosphatidylcholines	0-19	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	54-58
17042754-4	2006	Phosphatidylcholine content was decreased in erg2 and erg3 mutants; however, it was increased in erg6 strains as compared to normals.	Phosphatidylcholines	0-19	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	97-101
16828950-4	2006	Based on this model, the enhanced interaction power of TPL, as compared to that of HPL, into a phosphatidylcholine monolayer film, could be explained.	Phosphatidylcholines	95-114	pancreatic triacylglycerol lipase	Meleagris gallopavo	55-58
17015841-4	2006	Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine.	Phosphatidylcholines	114-133	patatin-like phospholipase domain containing 6	Mus musculus	0-26
17015841-4	2006	Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine.	Phosphatidylcholines	114-133	patatin-like phospholipase domain containing 6	Mus musculus	28-31
16962105-1	2006	C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface.	Phosphatidylcholines	85-104	C-reactive protein	Homo sapiens	0-18
16962105-1	2006	C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface.	Phosphatidylcholines	85-104	C-reactive protein	Homo sapiens	20-23
16854530-1	2006	The MDR3 protein is a transporter of phosphatidylcholine on the canalicular membrane of human hepatocytes.	Phosphatidylcholines	37-56	ATP binding cassette subfamily B member 4	Homo sapiens	4-8
16828950-4	2006	Based on this model, the enhanced interaction power of TPL, as compared to that of HPL, into a phosphatidylcholine monolayer film, could be explained.	Phosphatidylcholines	95-114	galectin 1	Homo sapiens	83-86
16837646-11	2006	Thus, Lpla2 has broad positional specificity for the sn-1 and sn-2 acyl groups in phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	82-101	phospholipase A2, group XV	Mus musculus	6-11
16779768-4	2006	The phosphatidylcholine/cholesterol/galactocerebroside lipid composition (PC/Chol/GalC, 1:0.35:0.125) was deposited onto the chitosan films.	Phosphatidylcholines	4-23	galactosylceramidase	Homo sapiens	82-86
16891548-8	2006	Disruption of both PLD zeta1 and PLD zeta2 function resulted in a smaller decrease in phosphatidylcholine and a smaller increase in digalactosyldiacylglycerol in phosphorus-starved roots.	Phosphatidylcholines	86-105	phospholipase D P1	Arabidopsis thaliana	19-42
16927188-2	2006	METHODS: AFM images of phosphatidylcholine/cholesterol vesicles were obtained using a mucin-coated mica substrate.	Phosphatidylcholines	23-42	LOC100508689	Homo sapiens	86-91
16763094-9	2006	Selective inhibition of iPLA(2)beta, but not iPLA(2)gamma, decreased several arachidonic acid-containing phospholipids, including 16:1-20:4, 16:0-20:4, 18:1-20:4, and 18:0-20:4 phosphatidylcholine, showing that the ability of iPLA(2)beta inhibitors to decrease cell growth correlates with their ability to decrease arachidonic acid-containing phospholipids.	Phosphatidylcholines	177-196	phospholipase A2 group VI	Homo sapiens	24-35
16961322-4	2006	The obtained fluorinated phosphatidylcholine poly(carbonate urethane)s (FPCPCU) possessed high molecular weight, narrower molecular weight distribution, and good mechanical properties as characterized by GPC and Instron, showing an increased hydrophilicity and a possible arrangement of surface structure as characterized by water contact angle.	Phosphatidylcholines	25-44	glycophorin C (Gerbich blood group)	Homo sapiens	204-207
16962371-5	2006	Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins.	Phosphatidylcholines	71-90	phospholipase A2 group X	Homo sapiens	16-23
16962371-5	2006	Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins.	Phosphatidylcholines	92-94	phospholipase A2 group X	Homo sapiens	16-23
16769123-1	2006	The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway.	Phosphatidylcholines	107-126	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	29-32
16769123-1	2006	The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway.	Phosphatidylcholines	107-126	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	82-85
17171187-1	2006	Cytidine 5"-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the biosynthetic pathway of structural phospholipids in cell membranes, particularly phosphatidylcholine.	Phosphatidylcholines	174-193	cut like homeobox 1	Homo sapiens	30-33
16857758-9	2006	IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes.	Phosphatidylcholines	67-86	interleukin-1 alpha	Ovis aries	0-9
17025673-9	2006	For comparison with similar phospholipids, the zeta potential of phosphatidylcholine interacting with Gd3+ was measured, showing an analogous behavior.	Phosphatidylcholines	65-84	GRDX	Homo sapiens	102-105
16924104-7	2006	Second, CLP gives a considerable (3-fold) increase in the amount of LTA(4) formed by 5LO, when present together with phosphatidylcholine.	Phosphatidylcholines	117-136	coactosin like F-actin binding protein 1	Homo sapiens	8-11
16777854-5	2006	Phosphatidylcholine turnover increased rapidly following inositol addition, a response that requires the participation of Nte1p, an endoplasmic reticulum-localized phospholipase B.	Phosphatidylcholines	0-19	lysophospholipase	Saccharomyces cerevisiae S288C	122-127
31627634-4	2006	In children, DM-1 was ascertained to be accompanied by not only atherogenic serum lipid metabolic disturbances (the elevated levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol), but also by the impaired lipid spectrum of erythrocytic membranes (reductions in the level of total lipids and the fraction of phosphatidylcholine (PC) with an increase in the level of fractions of tysophosphatidylcholine and phosphaUdylinositol; elevated levels of saturated fatty acids and decreased levels of unsaturated fatty acids in the fractions of PC and phosphatidylethanolamlne; the enhanced microviscosity of deep membranous layers and the modified outer membranous ones).	Phosphatidylcholines	348-367	immunoglobulin heavy diversity 1-7	Homo sapiens	13-17
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylcholines	204-223	FYN binding protein 1	Homo sapiens	93-97
16874306-0	2006	Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.	Phosphatidylcholines	11-30	CD1b molecule	Homo sapiens	94-98
16874306-5	2006	Using isoelectric focusing, native mass spectrometry and resolving the crystal structure at 1.8 A resolution, we found that human CD1b is simultaneously associated with endogenous phosphatidylcholine (PC) and a 41-44 carbon atoms-long spacer molecule.	Phosphatidylcholines	180-199	CD1b molecule	Homo sapiens	130-134
16874306-5	2006	Using isoelectric focusing, native mass spectrometry and resolving the crystal structure at 1.8 A resolution, we found that human CD1b is simultaneously associated with endogenous phosphatidylcholine (PC) and a 41-44 carbon atoms-long spacer molecule.	Phosphatidylcholines	201-203	CD1b molecule	Homo sapiens	130-134
16766520-3	2006	As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading.	Phosphatidylcholines	50-69	cut like homeobox 1	Homo sapiens	89-92
16766520-3	2006	As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading.	Phosphatidylcholines	71-73	cut like homeobox 1	Homo sapiens	89-92
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylcholines	204-223	PML-RARA regulated adaptor molecule 1	Homo sapiens	103-109
16879426-3	2006	Sphingomyelin synthase 1 functions by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol.	Phosphatidylcholines	80-99	sphingomyelin synthase 1	Mus musculus	0-24
16916782-1	2006	Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline.	Phosphatidylcholines	99-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
16843818-5	2006	PLD catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA).	Phosphatidylcholines	32-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
16820874-1	2006	Choline kinase alpha (ChoKalpha) is a metabolic enzyme involved in the synthesis of phosphatidylcholine, recently implicated in cancer onset since it is overexpressed in a variety of human cancers such as mammary, lung, colorectal and prostate adenocarcinomas.	Phosphatidylcholines	84-103	choline kinase alpha	Homo sapiens	0-20
16916782-1	2006	Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline.	Phosphatidylcholines	99-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
16756957-1	2006	Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine.	Phosphatidylcholines	115-134	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	0-44
16702602-0	2006	Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.	Phosphatidylcholines	42-61	ATP binding cassette subfamily G member 1	Homo sapiens	65-70
16702602-6	2006	Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1.	Phosphatidylcholines	102-121	ATP binding cassette subfamily G member 1	Homo sapiens	36-41
16702602-6	2006	Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1.	Phosphatidylcholines	102-121	ATP binding cassette subfamily A member 1	Homo sapiens	46-51
16702602-6	2006	Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1.	Phosphatidylcholines	123-125	ATP binding cassette subfamily G member 1	Homo sapiens	36-41
16702602-6	2006	Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted by ABCG1, whereas PCs were preferentially secreted by ABCA1.	Phosphatidylcholines	123-125	ATP binding cassette subfamily A member 1	Homo sapiens	46-51
16732058-2	2006	It has also been suggested that iPLA(2)beta is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate incorporation into phosphatidylcholine (PC).	Phosphatidylcholines	95-114	phospholipase A2, group VI	Mus musculus	32-43
16732058-2	2006	It has also been suggested that iPLA(2)beta is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate incorporation into phosphatidylcholine (PC).	Phosphatidylcholines	117-119	phospholipase A2, group VI	Mus musculus	32-43
16754725-0	2006	Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14.	Phosphatidylcholines	0-19	CD14 molecule	Homo sapiens	113-117
16880524-1	2006	A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	108-127	phospholipase A2, group XV	Mus musculus	2-28
16880524-1	2006	A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	108-127	phospholipase A2, group XV	Mus musculus	30-35
16880524-8	2006	A marked accumulation of phospholipids, in particular phosphatidylethanolamine and phosphatidylcholine, was found in the alveolar macrophages, the peritoneal macrophages, and the spleens of Lpla2-/- mice.	Phosphatidylcholines	83-102	phospholipase A2, group XV	Mus musculus	190-195
16756957-1	2006	Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine.	Phosphatidylcholines	115-134	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	46-50
16737317-0	2006	Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C. Fluorogenic analogues of phosphatidylcholine and lysophosphatidylcholine, DDPB and lysoDDPB, were synthesized by an enzyme-assisted strategy.	Phosphatidylcholines	117-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-70
16389649-5	2006	METHODS: Plasma PLTP activity was assayed by measuring the transfer of radiolabelled phosphatidylcholine from liposomes to HDL; apo AI and B by rate nephelometry and apo E by a 2-point turbidimetric assay.	Phosphatidylcholines	85-104	phospholipid transfer protein	Homo sapiens	16-20
16638972-1	2006	Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme.	Phosphatidylcholines	39-58	ras homolog family member A	Homo sapiens	127-131
16638972-1	2006	Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme.	Phosphatidylcholines	39-58	cell division cycle 42	Homo sapiens	133-138
16638972-1	2006	Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in complex regulation of this enzyme.	Phosphatidylcholines	39-58	Rac family small GTPase 1	Homo sapiens	144-148
16565064-0	2006	Cytochrome C interaction with cardiolipin/phosphatidylcholine model membranes: effect of cardiolipin protonation.	Phosphatidylcholines	42-61	cytochrome c, somatic	Homo sapiens	0-12
16709158-1	2006	The major PI (phosphatidylinositol)/PC (phosphatidylcholine)-transfer protein in yeast, Sec14p, co-ordinates lipid metabolism with protein transport from the Golgi complex.	Phosphatidylcholines	40-59	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	88-94
16565064-1	2006	Resonance energy transfer between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cytochrome c (cyt c) as an acceptor has been employed to explore the protein binding to model membranes, composed of phosphatidylcholine and cardiolipin (CL).	Phosphatidylcholines	222-241	cytochrome c, somatic	Homo sapiens	105-117
16565064-1	2006	Resonance energy transfer between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cytochrome c (cyt c) as an acceptor has been employed to explore the protein binding to model membranes, composed of phosphatidylcholine and cardiolipin (CL).	Phosphatidylcholines	222-241	cytochrome c, somatic	Homo sapiens	119-124
16461407-5	2006	By using phosphatidylcholine/phosphatidylglycerol model systems, we show that local enrichment of anionic lipids into fluid domains triggers PLA2-IIA activity.	Phosphatidylcholines	9-28	phospholipase A2 group IIA	Homo sapiens	141-145
16631150-4	2006	It is shown that the spectral peaks assigned to the methyl head groups of phosphatidylcholine and sphingomyelin in the (1)H spectra of LDL exhibit line broadening when otherwise free thiol groups of apoB are covalently modified by methanethiosulfonate spin label.	Phosphatidylcholines	74-93	apolipoprotein B	Homo sapiens	199-203
16582425-10	2006	It has previously been shown that defects in phosphatidylcholine synthesis (cho2 and opi3) yield the Opi(-) phenotype because of a buildup of PA.	Phosphatidylcholines	45-64	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	76-80
16582425-10	2006	It has previously been shown that defects in phosphatidylcholine synthesis (cho2 and opi3) yield the Opi(-) phenotype because of a buildup of PA.	Phosphatidylcholines	45-64	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	85-89
16669622-3	2006	Wide line 2H and 31P NMR spectra of phospholipid vesicles revealed that alpha-syn associates with membranes containing lipids with anionic headgroups and can disrupt the integrity of the lipid bilayer, but the protein has little effect on membranes of zwitterionic phosphatidylcholine.	Phosphatidylcholines	265-284	synuclein alpha	Homo sapiens	72-81
16925521-3	2006	Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA.	Phosphatidylcholines	167-186	macrophage scavenger receptor 1	Mus musculus	10-36
16925521-3	2006	Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA.	Phosphatidylcholines	167-186	macrophage scavenger receptor 1	Mus musculus	38-41
16925521-3	2006	Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA.	Phosphatidylcholines	167-186	macrophage scavenger receptor 1	Mus musculus	116-119
16925521-3	2006	Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA.	Phosphatidylcholines	167-186	macrophage scavenger receptor 1	Mus musculus	116-119
16641205-6	2006	Phosphatidylcholine comprised 41 +/- 19% of the total phospholipid in the BAL fluid of the ABCA3 group compared with 78 +/- 3% and 68 +/- 18%, p = 0.008 and 0.05, of the CON and SP-B groups, respectively.	Phosphatidylcholines	0-19	ATP binding cassette subfamily A member 3	Homo sapiens	91-96
16641205-6	2006	Phosphatidylcholine comprised 41 +/- 19% of the total phospholipid in the BAL fluid of the ABCA3 group compared with 78 +/- 3% and 68 +/- 18%, p = 0.008 and 0.05, of the CON and SP-B groups, respectively.	Phosphatidylcholines	0-19	surfactant protein B	Homo sapiens	178-182
16641205-8	2006	We conclude that mutations in ABCA3 are associated with surfactant that is deficient in phosphatidylcholine and has decreased function, suggesting that ABCA3 plays an important role in pulmonary surfactant phospholipid homeostasis.	Phosphatidylcholines	88-107	ATP binding cassette subfamily A member 3	Homo sapiens	30-35
16641205-8	2006	We conclude that mutations in ABCA3 are associated with surfactant that is deficient in phosphatidylcholine and has decreased function, suggesting that ABCA3 plays an important role in pulmonary surfactant phospholipid homeostasis.	Phosphatidylcholines	88-107	ATP binding cassette subfamily A member 3	Homo sapiens	152-157
16618126-6	2006	The purified Atp8a1 is inactive in detergent micelles or in micelles containing phosphatidylcholine, phosphatidic acid, or phosphatidylinositol, is minimally activated by phosphatidylglycerol or phosphatidylethanolamine (PE), and is maximally activated by PS.	Phosphatidylcholines	80-99	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	13-19
16611377-8	2006	The phosphatidylcholine:phosphatidylethanolamine ratio in rat liver increased with rising dietary methionine concentration; the relative mRNA concentrations of phosphatidylethanolamine N-methyltransferase and cystathionine beta-synthase remained unaffected.	Phosphatidylcholines	4-23	cystathionine beta synthase	Rattus norvegicus	209-236
16679290-2	2006	In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	10-12	phosphatidylethanolamine N-methyltransferase	Mus musculus	80-124
16679290-2	2006	In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	10-12	phosphatidylethanolamine N-methyltransferase	Mus musculus	126-130
16679290-4	2006	Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile.	Phosphatidylcholines	112-114	phosphatidylethanolamine N-methyltransferase	Mus musculus	48-52
16679290-4	2006	Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile.	Phosphatidylcholines	112-114	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	57-90
16679290-4	2006	Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile.	Phosphatidylcholines	112-114	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	92-96
16840176-1	2006	In the authors" previous studies, they found that phosphatidylcholine-specific phospholipase C (PC-PLC) and phosphatidylinositol-specific phospholipase C (PI-PLC) played contrary roles in the apoptosis of vascular endothelial cells (VECs), but the mechanism underlying the phenomenon remains unclear.	Phosphatidylcholines	50-69	phospholipase C beta 1	Homo sapiens	155-161
16754327-2	2006	The PC and other glycerophospholipid compositions of membranes change dynamically through stimulus-dependent and independent pathways, principally by the action of two different types of enzymes; phospholipase A2 [EC 3.1.1.4] and acyl-CoA:lysophospholipid acyltransferase [EC 2.3.1.23].	Phosphatidylcholines	4-6	phospholipase A2 group IB	Homo sapiens	196-212
16732739-6	2006	Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br-) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine.	Phosphatidylcholines	226-245	myeloperoxidase	Homo sapiens	99-102
16732739-6	2006	Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br-) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine.	Phosphatidylcholines	226-245	myeloperoxidase	Homo sapiens	176-179
16415354-8	2006	Silencing of ABCA3 expression also reduced vesicular uptake of surfactant lipids phosphatidylcholine, sphingomyelin, and cholesterol but not phosphatidylethanolamine.	Phosphatidylcholines	81-100	ATP binding cassette subfamily A member 3	Homo sapiens	13-18
16500904-2	2006	Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL).	Phosphatidylcholines	85-104	apolipoprotein A1	Homo sapiens	0-18
16500904-2	2006	Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL).	Phosphatidylcholines	85-104	ATP binding cassette subfamily A member 1	Homo sapiens	28-33
16500904-2	2006	Apolipoprotein A-I binds to ABCA1 and cellular cholesterol and phospholipids, mainly phosphatidylcholine, are loaded onto apoA-I to form pre-beta high density lipoprotein (HDL).	Phosphatidylcholines	85-104	apolipoprotein A1	Homo sapiens	122-128
16500904-6	2006	Purified ABCA1 showed robust ATPase activity when reconstituted in liposomes made of synthetic phosphatidylcholine.	Phosphatidylcholines	95-114	ATP binding cassette subfamily A member 1	Homo sapiens	9-14
16500904-6	2006	Purified ABCA1 showed robust ATPase activity when reconstituted in liposomes made of synthetic phosphatidylcholine.	Phosphatidylcholines	95-114	dynein axonemal heavy chain 8	Homo sapiens	29-35
16500904-11	2006	These results suggest that the ATPase activity of ABCA1 is stimulated preferentially by phospholipids with choline head groups, phosphatidylcholine and sphingomyelin.	Phosphatidylcholines	128-147	dynein axonemal heavy chain 8	Homo sapiens	31-37
16500904-11	2006	These results suggest that the ATPase activity of ABCA1 is stimulated preferentially by phospholipids with choline head groups, phosphatidylcholine and sphingomyelin.	Phosphatidylcholines	128-147	ATP binding cassette subfamily A member 1	Homo sapiens	50-55
16466701-2	2006	We reported in a previous study that HePC interferes with phosphatidylcholine (PC) synthesis in HepG2 cells via both CDP-choline and phosphatidylethanolamine (PE) methylation.	Phosphatidylcholines	39-41	cut like homeobox 1	Homo sapiens	117-120
16415354-9	2006	We conclude that ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures.	Phosphatidylcholines	60-79	ATP binding cassette subfamily A member 3	Homo sapiens	17-22
16674912-0	2006	Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position.	Phosphatidylcholines	56-76	paraoxonase 1	Homo sapiens	26-30
16674912-6	2006	In contrast, phosphatidylserine and phosphatidic acid (&gt; or =0.1 mM) inhibited both activities Further, such a preferable stimulation of arylesterase activity by phosphatidylcholines was also reproduced with VLDL-bound PON1, although to a less extent.	Phosphatidylcholines	165-185	paraoxonase 1	Homo sapiens	222-226
16609691-0	2006	Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity.	Phosphatidylcholines	114-133	phospholipid transfer protein	Homo sapiens	7-36
16309859-4	2006	NTE is localised to the cytoplasmic face of the endoplasmic reticulum (ER) and catalyses the deacylation of ER-membrane phosphatidylcholine (PtdCho) to soluble products-glycerophosphocholine and fatty acids.	Phosphatidylcholines	120-139	patatin-like phospholipase domain containing 6	Mus musculus	0-3
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylcholines	169-188	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	22-27
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylcholines	169-188	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	32-37
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylcholines	190-192	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	22-27
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylcholines	190-192	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	32-37
16445898-3	2006	In this paper a simple model system was used: unsaturated phosphatidylcholine (PC) vesicles were treated with HOCl in the presence of varying NaNO2 concentrations and the yield of reaction products was determined by MALDI-TOF MS: the extent of chlorohydrin generation was significantly reduced in the presence of NaNO2 because HOCl is consumed by the oxidation of NO2- to NO3-.	Phosphatidylcholines	79-81	NBL1, DAN family BMP antagonist	Homo sapiens	372-375
16553452-2	2006	Steady-state fluorescence anisotropy measurements of diphenylhexatriene (DPH) chain-labeled phosphatidylcholine (DPH-PC) revealed significant dips at several POPE-to-phospholipid mole fractions (X(PE)"s) when the cholesterol-to-lipid mole fraction (X(CHOL)) was fixed at 0.00, 0.35, 0.40, and 0.50.	Phosphatidylcholines	92-111	damage specific DNA binding protein 1	Homo sapiens	195-200
16445995-0	2006	Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	89-108	chromogranin A	Sus scrofa	16-30
16309859-4	2006	NTE is localised to the cytoplasmic face of the endoplasmic reticulum (ER) and catalyses the deacylation of ER-membrane phosphatidylcholine (PtdCho) to soluble products-glycerophosphocholine and fatty acids.	Phosphatidylcholines	141-147	patatin-like phospholipase domain containing 6	Mus musculus	0-3
16309859-6	2006	Yeast mutants lacking NTE are viable because they maintain membrane homeostasis by reducing the rate of PtdCho synthesis.	Phosphatidylcholines	104-110	patatin-like phospholipase domain containing 6	Mus musculus	22-25
16412504-7	2006	PMCA activity was two to three times higher when the surrounding phosphatidylcholine molecules contained acyl chains that were ordered (stiff) compared to disordered (fluid) acyl chains.	Phosphatidylcholines	65-84	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	0-4
16466687-1	2006	CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	92-111	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
16466687-1	2006	CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	92-111	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-49
16466687-1	2006	CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	113-119	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
16466687-1	2006	CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	113-119	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-49
16380371-0	2006	CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.	Phosphatidylcholines	35-54	phospholipase A2 group IB	Homo sapiens	90-106
16380371-3	2006	PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).	Phosphatidylcholines	0-6	phospholipase A2 group IB	Homo sapiens	24-40
16380371-3	2006	PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).	Phosphatidylcholines	0-6	phospholipase A2 group IB	Homo sapiens	42-46
16380371-3	2006	PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).	Phosphatidylcholines	0-6	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	98-113
16380371-3	2006	PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).	Phosphatidylcholines	0-6	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	115-118
16453359-4	2006	These compounds contain alpha-D-glucose in the sn-2 position of the glycerol backbone of phosphatidylcholine (PC) and platelet-activating factor (PAF), which gives rise to 2-glucophosphatidylcholine (Glc-PC) and 1-O-octadecyl-2-O-alpha-d-glucopyranosyl-sn-2-glycero-3-phosphatidylcholine (Glc-PAF), respectively.	Phosphatidylcholines	89-108	PCNA clamp associated factor	Homo sapiens	293-296
16453359-4	2006	These compounds contain alpha-D-glucose in the sn-2 position of the glycerol backbone of phosphatidylcholine (PC) and platelet-activating factor (PAF), which gives rise to 2-glucophosphatidylcholine (Glc-PC) and 1-O-octadecyl-2-O-alpha-d-glucopyranosyl-sn-2-glycero-3-phosphatidylcholine (Glc-PAF), respectively.	Phosphatidylcholines	110-112	PCNA clamp associated factor	Homo sapiens	293-296
16412504-9	2006	PMCA associates much more strongly with phosphatidylcholine containing disordered hydrocarbon chains than ordered hydrocarbon chains.	Phosphatidylcholines	40-59	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	0-4
16482629-11	2006	In contrast, phosphatidylcholine pretreatment prevented the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity and the mast cell degranulation increased.	Phosphatidylcholines	13-32	myeloperoxidase	Canis lupus familiaris	128-143
16376450-2	2006	The multidrug resistant 2 (Mdr2) P-glycoprotein encodes for the canalicular phospholipid transporter, and Mdr2 (+/-) mice secrete 40% less phosphatidylcholine than wild-type mice.	Phosphatidylcholines	139-158	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	27-31
16376450-2	2006	The multidrug resistant 2 (Mdr2) P-glycoprotein encodes for the canalicular phospholipid transporter, and Mdr2 (+/-) mice secrete 40% less phosphatidylcholine than wild-type mice.	Phosphatidylcholines	139-158	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	106-110
16371353-0	2006	A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	97-116	choline kinase beta	Mus musculus	56-75
16371353-5	2006	CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine.	Phosphatidylcholines	193-212	choline kinase beta	Homo sapiens	0-4
16371353-5	2006	CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine.	Phosphatidylcholines	193-212	choline kinase alpha	Homo sapiens	29-43
16371353-5	2006	CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid phosphatidylcholine.	Phosphatidylcholines	193-212	choline kinase alpha	Homo sapiens	0-3
16259620-4	2006	CA-C had a greater affinity for negatively charged lipids (phosphatidic acid and phosphatidylserine) than for zwitterionic lipids [PC/Cho/SM (equimolar mixture of phosphatidylcholine, cholesterol and sphingomyelin) and phosphatidylcholine].	Phosphatidylcholines	163-182	carbonic anhydrase 2	Homo sapiens	0-4
16259620-4	2006	CA-C had a greater affinity for negatively charged lipids (phosphatidic acid and phosphatidylserine) than for zwitterionic lipids [PC/Cho/SM (equimolar mixture of phosphatidylcholine, cholesterol and sphingomyelin) and phosphatidylcholine].	Phosphatidylcholines	219-238	carbonic anhydrase 2	Homo sapiens	0-4
16146428-4	2006	In the present paper, we report that alpha-syn bound to small unilamellar liposomes composed of phosphatidylcholine/phosphatidic acid is resistant to oxidation and nitration when compared with soluble alpha-syn.	Phosphatidylcholines	96-115	synuclein alpha	Homo sapiens	37-46
16286468-1	2006	Studies involving pharmacologic inhibition or transient reduction of Group VIA phospholipase A2 (iPLA2beta) expression have suggested that it is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels, rates of arachidonate incorporation into phospholipids, and degradation of excess phosphatidylcholine (PC).	Phosphatidylcholines	193-212	phospholipase A2 group IB	Rattus norvegicus	79-95
16286468-1	2006	Studies involving pharmacologic inhibition or transient reduction of Group VIA phospholipase A2 (iPLA2beta) expression have suggested that it is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels, rates of arachidonate incorporation into phospholipids, and degradation of excess phosphatidylcholine (PC).	Phosphatidylcholines	193-212	phospholipase A2 group VI	Rattus norvegicus	97-106
16024567-3	2006	AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway.	Phosphatidylcholines	41-43	phospholipase A2	Oryctolagus cuniculus	82-98
16024567-3	2006	AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway.	Phosphatidylcholines	41-43	phospholipase A2	Oryctolagus cuniculus	100-104
16679530-4	2006	PMCA was photolabeled in mixed micelles containing detergent, the phosphatidylcholine photoactivatable analog 1-palmitoyl-2-[9-[2"-[125I]iodo-4"- (trifluoromethyldiazirinyl)-benzyloxycarbonyl]-nonaoyl]-sn-glycero-3-phosphocholine, and different amounts of dimyristoyl phosphatidylcholine (PC).	Phosphatidylcholines	66-85	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	0-4
16845888-0	2006	Regulation of phosphatidylcholine homeostasis by Sec14.	Phosphatidylcholines	14-33	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	49-54
16845888-3	2006	Yeast studies have determined that the phosphatidylcholine and (or) phosphatidylinositol binding protein, Sec14, is a major regulator of phosphatidylcholine homeostasis.	Phosphatidylcholines	39-58	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	106-111
16845888-3	2006	Yeast studies have determined that the phosphatidylcholine and (or) phosphatidylinositol binding protein, Sec14, is a major regulator of phosphatidylcholine homeostasis.	Phosphatidylcholines	137-156	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	106-111
16845888-4	2006	Sec14 itself regulates vesicular transport from the Golgi, and the interrelationship between phosphatidylcholine metabolism and membrane movement within the cell is described in detail.	Phosphatidylcholines	93-112	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
16679530-4	2006	PMCA was photolabeled in mixed micelles containing detergent, the phosphatidylcholine photoactivatable analog 1-palmitoyl-2-[9-[2"-[125I]iodo-4"- (trifluoromethyldiazirinyl)-benzyloxycarbonyl]-nonaoyl]-sn-glycero-3-phosphocholine, and different amounts of dimyristoyl phosphatidylcholine (PC).	Phosphatidylcholines	289-291	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	0-4
16679530-6	2006	We determined a maximum number of 17 +/- 1 molecules of PC in close contact with the transmembrane surface per PMCA molecule.	Phosphatidylcholines	56-58	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	111-115
16719778-2	2006	ChoK is important for the generation of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM) and subsequently for the cell division.	Phosphatidylcholines	74-93	choline kinase alpha	Mus musculus	0-4
16719778-2	2006	ChoK is important for the generation of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM) and subsequently for the cell division.	Phosphatidylcholines	95-97	choline kinase alpha	Mus musculus	0-4
16679769-3	2006	PS can be decarboxylated to PE, and PC is synthesized from PE by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	36-38	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	65-109
16679769-3	2006	PS can be decarboxylated to PE, and PC is synthesized from PE by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	36-38	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	111-115
16400173-2	2006	PLD catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid (PA) and choline.	Phosphatidylcholines	32-51	phospholipase D	Saccharomyces cerevisiae S288C	0-3
16332136-2	2005	The kinetics of breakdown of the bovine milk allergen alpha-lactalbumin during in vitro gastrointestinal digestion was found to be altered by interactions with physiologically relevant levels of phosphatidylcholine (PC), a surfactant that is abundant both in milk and is actively secreted by the stomach.	Phosphatidylcholines	195-214	lactalbumin alpha	Bos taurus	54-71
16878701-1	2006	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
16878701-1	2006	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
16054134-9	2006	We show that this activity uses palmitoyl coenzyme A as an acyl donor, unlike LRAT which uses phosphatidylcholine.	Phosphatidylcholines	94-113	lecithin retinol acyltransferase	Homo sapiens	78-82
17047345-8	2006	The increased PC content was attributed to an increased synthesis, as measured by [methyl-(14)C]choline incorporation into PC and high CTP:phosphocholine cytidylyltransferase-alpha mRNA expression.	Phosphatidylcholines	14-16	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	135-180
16226406-1	2005	Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG).	Phosphatidylcholines	176-195	sphingomyelin synthase 1	Mus musculus	0-24
16226406-1	2005	Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG).	Phosphatidylcholines	176-195	sphingomyelin synthase 1	Mus musculus	26-30
16332136-2	2005	The kinetics of breakdown of the bovine milk allergen alpha-lactalbumin during in vitro gastrointestinal digestion was found to be altered by interactions with physiologically relevant levels of phosphatidylcholine (PC), a surfactant that is abundant both in milk and is actively secreted by the stomach.	Phosphatidylcholines	216-218	lactalbumin alpha	Bos taurus	54-71
16144842-1	2005	In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation.	Phosphatidylcholines	115-134	phosphatidylethanolamine N-methyltransferase	Mus musculus	143-187
16157598-1	2005	Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes.	Phosphatidylcholines	0-19	cut-like homeobox 1	Mus musculus	41-44
16157598-1	2005	Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes.	Phosphatidylcholines	0-19	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	87-126
16157598-1	2005	Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes.	Phosphatidylcholines	0-19	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	147-153
16157598-1	2005	Phosphatidylcholine biosynthesis via the CDP-choline pathway is primarily regulated by CTP:phosphocholine cytidylyltransferase (CT) encoded by the Pcyt1a and Pcyt1b genes.	Phosphatidylcholines	0-19	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	158-164
16550803-10	2005	In contrast, PC pretreatment reversed the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity increases, and the mast cell degranulation.	Phosphatidylcholines	13-15	myeloperoxidase	Canis lupus familiaris	110-125
16172116-1	2005	In eukaryotes, neuropathy target esterase (Nte1p in yeast) deacylates phosphatidylcholine derived exclusively from the CDP-choline pathway to produce glycerophosphocholine (GroPCho) and release two fatty acids.	Phosphatidylcholines	70-89	lysophospholipase	Saccharomyces cerevisiae S288C	43-48
16274224-0	2005	Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.	Phosphatidylcholines	38-57	phosphatidylinositol transfer protein, beta	Rattus norvegicus	13-21
16204231-1	2005	Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast.	Phosphatidylcholines	23-42	Lem3p	Saccharomyces cerevisiae S288C	99-104
16204231-1	2005	Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast.	Phosphatidylcholines	23-42	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	106-111
16204231-1	2005	Acyl chain-labeled NBD-phosphatidylcholine (NBD-PC) has been used to identify three gene products (Lem3p, Dnf1p, and Dnf2p) that are required for normal levels of inward-directed phospholipid transport (flip) across the plasma membrane of yeast.	Phosphatidylcholines	23-42	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	117-122
16236715-8	2005	Oxidized phosphatidylcholine (1-palmitoyl-2-linoleoyl) when hydrolyzed with phospholipase A(2) also evoked intracellular calcium mobilization in G2A-expressing cells.	Phosphatidylcholines	9-28	G protein-coupled receptor 132	Homo sapiens	145-148
16236715-9	2005	These results indicate that G2A is activated by oxidized free fatty acids produced by oxidation and subsequent hydrolysis of phosphatidylcholine or cholesteryl linoleate.	Phosphatidylcholines	125-144	G protein-coupled receptor 132	Homo sapiens	28-31
16099870-1	2005	Phosphatidylcholine transfer protein (PC-TP) is a steroidogenic acute regulatory-related transfer domain protein that is enriched in liver cytosol and binds phosphatidylcholines with high specificity.	Phosphatidylcholines	157-177	phosphatidylcholine transfer protein	Mus musculus	0-36
16099870-1	2005	Phosphatidylcholine transfer protein (PC-TP) is a steroidogenic acute regulatory-related transfer domain protein that is enriched in liver cytosol and binds phosphatidylcholines with high specificity.	Phosphatidylcholines	157-177	phosphatidylcholine transfer protein	Mus musculus	38-43
16099870-2	2005	In tissue culture systems, PC-TP promotes ATP-binding cassette protein A1-mediated efflux of cholesterol and phosphatidylcholine molecules as nascent pre-beta-high-density lipoprotein (HDL) particles.	Phosphatidylcholines	109-128	phosphatidylcholine transfer protein	Mus musculus	27-32
16109976-11	2005	Anti-CD18 antibody administration inhibited only endotoxin-induced but not IL-1-induced increases in surfactant protein mRNA and surfactant saturated phosphatidylcholine.	Phosphatidylcholines	150-169	integrin beta-2	Ovis aries	5-9
16144842-1	2005	In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation.	Phosphatidylcholines	115-134	phosphatidylethanolamine N-methyltransferase	Mus musculus	189-193
16144842-1	2005	In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation.	Phosphatidylcholines	136-138	phosphatidylethanolamine N-methyltransferase	Mus musculus	143-187
16144842-1	2005	In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation.	Phosphatidylcholines	136-138	phosphatidylethanolamine N-methyltransferase	Mus musculus	189-193
16216074-3	2005	To investigate the structural basis of phospholipid binding further, GM2AP was cocrystallized with phosphatidylcholine (PC), known to interact with GM2AP.	Phosphatidylcholines	99-118	GM2 ganglioside activator protein	Mus musculus	148-153
16201749-5	2005	Surface plasmon resonance was employed to quantitate the interaction between PP1c gamma and immobilized mixed lipid vesicles of PA/phosphatidylcholine (PC) or PC alone.	Phosphatidylcholines	131-150	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	77-81
16137924-5	2005	Unlike wild-type yeast, mutants lacking NTE activity cannot deacylate CDP-choline pathway-synthesized phosphatidylcholine (PtdCho) to glycerophosphocholine (GroPCho) and fatty acids.	Phosphatidylcholines	102-121	patatin like phospholipase domain containing 6	Homo sapiens	40-43
16153613-5	2005	CDP-choline liposomes deliver the agent intact to the brain, circumventing the rate-limiting, cytidine triphosphate:phosphocholine cytidylyltransferase in phosphatidylcholine synthesis.	Phosphatidylcholines	155-174	cut-like homeobox 1	Rattus norvegicus	0-3
16179605-1	2005	Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules.	Phosphatidylcholines	57-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
16179605-1	2005	Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules.	Phosphatidylcholines	57-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
16156665-3	2005	The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC).	Phosphatidylcholines	281-300	phospholipase A2 group IID	Homo sapiens	53-61
16156665-3	2005	The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC).	Phosphatidylcholines	302-304	phospholipase A2 group IID	Homo sapiens	53-61
16137924-5	2005	Unlike wild-type yeast, mutants lacking NTE activity cannot deacylate CDP-choline pathway-synthesized phosphatidylcholine (PtdCho) to glycerophosphocholine (GroPCho) and fatty acids.	Phosphatidylcholines	123-129	patatin like phospholipase domain containing 6	Homo sapiens	40-43
16137924-7	2005	A complex of PtdCho and Sec14p, a yeast phospholipid-binding protein, both inhibits the rate-limiting step in PtdCho synthesis and enhances deacylation of PtdCho by NTE.	Phosphatidylcholines	13-19	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	24-30
16137924-7	2005	A complex of PtdCho and Sec14p, a yeast phospholipid-binding protein, both inhibits the rate-limiting step in PtdCho synthesis and enhances deacylation of PtdCho by NTE.	Phosphatidylcholines	13-19	patatin like phospholipase domain containing 6	Homo sapiens	165-168
16142924-4	2005	Using a freeze-thaw procedure, purified rOCT1 was reconstituted into proteoliposomes formed from phosphatidylcholine, phosphatidylserine, and cholesterol.	Phosphatidylcholines	97-116	solute carrier family 22 member 1	Rattus norvegicus	40-45
16166305-8	2005	In particular, TRAIL-induced alteration of mitochondrial lipids follows an imbalance in the cellular homeostasis of phosphatidylcholine, which results in an elevation in diacylglycerol (DAG).	Phosphatidylcholines	116-135	TNF superfamily member 10	Homo sapiens	15-20
16195591-1	2005	Lymphatic recovery of cholesterol infused into the duodenum as bile salt micelles containing phosphatidylcholine (PC) was accelerated by the co-administration of phospholipase A2 in bile and pancreatic juice diverted rats.	Phosphatidylcholines	93-112	phospholipase A2 group IB	Rattus norvegicus	162-178
16131098-4	2005	The conversion efficiency of phosphatidyl choline to choline was 50% at 0.2 mL min(-1).	Phosphatidylcholines	29-49	CD59 molecule (CD59 blood group)	Homo sapiens	79-85
16195591-1	2005	Lymphatic recovery of cholesterol infused into the duodenum as bile salt micelles containing phosphatidylcholine (PC) was accelerated by the co-administration of phospholipase A2 in bile and pancreatic juice diverted rats.	Phosphatidylcholines	114-116	phospholipase A2 group IB	Rattus norvegicus	162-178
15901801-1	2005	Our previous study showed that rilmenidine, a selective I(1)-imidazoline receptor agonist, enhanced the phosphorylation of mitogen-activated protein kinase (MAPK)(p42/44), via the phosphatidylcholine-specific phospholipase C pathway in the pheochromocytoma cell line (PC12).	Phosphatidylcholines	180-199	mitogen activated protein kinase 3	Rattus norvegicus	157-161
16463138-2	2005	We investigated Bax and tBid interactions with (i) phosphatidylcholine (PC) monolayer as the main component of the outer leaflet of the outer membrane, (ii) with phosphatidylethanolamine (PE) and phosphatidylserine (PS) that are present in the inner leaflet and (iii) with a mixed PC/PE/Cardiolipin (CL) monolayer of the contact sites between the outer and inner membranes.	Phosphatidylcholines	51-70	BCL2 associated X, apoptosis regulator	Homo sapiens	16-19
15911624-3	2005	We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement.	Phosphatidylcholines	52-71	StAR related lipid transfer domain containing 10	Homo sapiens	29-36
16213900-1	2005	BACKGROUND: Lysophosphatidylcholine (LysoPC) is a product of phosphatidylcholine hydrolysis by phospholipase A2, which is associated with atherosclerosis.	Phosphatidylcholines	16-35	phospholipase A2 group IB	Homo sapiens	95-111
15979580-0	2005	GPI-alkaline phosphatase insertion into phosphatidylcholine monolayers: phase behavior and morphology changes.	Phosphatidylcholines	40-59	glucose-6-phosphate isomerase	Bos taurus	0-3
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylcholines	152-171	coagulation factor X	Homo sapiens	77-86
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylcholines	173-175	coagulation factor X	Homo sapiens	77-86
16092060-4	2005	The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I).	Phosphatidylcholines	4-24	apolipoprotein A1	Homo sapiens	84-91
16092060-4	2005	The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I).	Phosphatidylcholines	4-24	apolipoprotein A1	Homo sapiens	151-158
16092060-4	2005	The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I).	Phosphatidylcholines	26-29	apolipoprotein A1	Homo sapiens	84-91
16092060-4	2005	The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I).	Phosphatidylcholines	26-29	apolipoprotein A1	Homo sapiens	151-158
16051517-5	2005	Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells.	Phosphatidylcholines	141-160	phospholipase A2 activating protein	Homo sapiens	47-51
16051517-5	2005	Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells.	Phosphatidylcholines	162-164	phospholipase A2 activating protein	Homo sapiens	47-51
16051693-1	2005	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis.	Phosphatidylcholines	62-81	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
16051693-1	2005	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis.	Phosphatidylcholines	62-81	phosphatidylethanolamine N-methyltransferase	Homo sapiens	46-50
16200394-8	2005	Thus, using information on the known molecular structures of tested phospholipids, a phosphatidylcholine residue in alpha-position and a short chain length fatty acid esterified in beta-position seem essential for activation of ecto-5"-nucleotidase by glycerophospholipids.	Phosphatidylcholines	85-104	5'-nucleotidase ecto	Homo sapiens	228-248
15936720-5	2005	Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC.	Phosphatidylcholines	87-89	choline phosphotransferase 1	Homo sapiens	0-25
15936720-5	2005	Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC.	Phosphatidylcholines	87-89	choline phosphotransferase 1	Homo sapiens	27-30
15936720-12	2005	Furthermore, the activity of CPT in forming PC is increased in the breast cancer cell lines cultured for 24 h. Additionally, we examined the CPT activity in the presence of nanomolar concentrations of Ro5-4864.	Phosphatidylcholines	44-46	choline phosphotransferase 1	Homo sapiens	29-32
15911624-3	2005	We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement.	Phosphatidylcholines	73-75	StAR related lipid transfer domain containing 10	Homo sapiens	29-36
15911624-7	2005	StarD10 was further shown to bind lipids in vivo by cross-linking of protein expressed in transfected HEK-293T cells with photoactivable phosphatidylcholine.	Phosphatidylcholines	137-156	StAR related lipid transfer domain containing 10	Homo sapiens	0-7
16002697-0	2005	Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.	Phosphatidylcholines	57-76	CD1d1 antigen	Mus musculus	27-31
15919656-1	2005	The Saccharomyces cerevisiae CKI1-encoded choline kinase catalyzes the committed step in phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	89-108	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	29-33
16002697-2	2005	In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine.	Phosphatidylcholines	79-98	CD1d1 antigen	Mus musculus	65-69
15982005-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the rate-limiting step in phosphatidylcholine (PC) synthesis, and its activity is regulated by reversible association with membranes, mediated by an amphipathic helical domain M. Here we describe a new feature of the CCTalpha isoform, vesicle tethering.	Phosphatidylcholines	82-101	phosphate cytidylyltransferase 1A, choline	Homo sapiens	273-281
15982005-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the rate-limiting step in phosphatidylcholine (PC) synthesis, and its activity is regulated by reversible association with membranes, mediated by an amphipathic helical domain M. Here we describe a new feature of the CCTalpha isoform, vesicle tethering.	Phosphatidylcholines	103-105	phosphate cytidylyltransferase 1A, choline	Homo sapiens	273-281
15849246-2	2005	In this work isothermal titration calorimetry, circular dichroism spectroscopy, and two-photon microscopy are used to study the interaction of lipid-free apolipoprotein A-I (apoA-I) with small unilamellar vesicles (SUVs) of 1-palmitoyl, 2-oleoyl phosphatidylcholine (POPC) and sphingomyelin (SM), with and without cholesterol.	Phosphatidylcholines	267-271	apolipoprotein A1	Homo sapiens	154-172
15764643-2	2005	Secretion of saturated phosphatidylcholine was decreased 40-60% by expression of TGF-alpha.	Phosphatidylcholines	23-42	transforming growth factor alpha	Mus musculus	81-90
15849246-2	2005	In this work isothermal titration calorimetry, circular dichroism spectroscopy, and two-photon microscopy are used to study the interaction of lipid-free apolipoprotein A-I (apoA-I) with small unilamellar vesicles (SUVs) of 1-palmitoyl, 2-oleoyl phosphatidylcholine (POPC) and sphingomyelin (SM), with and without cholesterol.	Phosphatidylcholines	267-271	apolipoprotein A1	Homo sapiens	174-180
15834125-1	2005	We assessed the ability of endothelial lipase (EL) to hydrolyze the sn-1 and sn-2 fatty acids (FAs) from HDL phosphatidylcholine.	Phosphatidylcholines	109-128	lipase G, endothelial type	Homo sapiens	27-45
15866882-10	2005	In contrast to cPLA(2)alpha, cPLA(2)zeta preferred phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	79-98	phospholipase A2, group IVF	Mus musculus	29-40
15924269-3	2005	Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center.	Phosphatidylcholines	84-103	proline rich transmembrane protein 2	Homo sapiens	42-45
15924269-3	2005	Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center.	Phosphatidylcholines	105-107	proline rich transmembrane protein 2	Homo sapiens	42-45
15924269-3	2005	Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific phospholipase D, and cross-talk exists between the glycerolipid and sphingolipid pathways, with PKC at the center.	Phosphatidylcholines	105-107	proline rich transmembrane protein 2	Homo sapiens	214-217
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	steroidogenic acute regulatory protein	Homo sapiens	112-118
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 3	Homo sapiens	119-125
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 5	Homo sapiens	126-132
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 5	Homo sapiens	134-140
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	phosphatidylcholine transfer protein	Homo sapiens	142-148
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 10	Homo sapiens	149-156
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	StAR related lipid transfer domain containing 10	Homo sapiens	158-165
15976441-3	2005	Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.	Phosphatidylcholines	36-55	ceramide transporter 1	Homo sapiens	170-177
15834125-6	2005	The lack of phospholipase A(2) activity of EL and its ability to liberate [(14)C]FA from [(14)C]lysophosphatidylcholine (lyso-PC) led us to conclude that EL-mediated deacylation of phosphatidylcholine (PC) is initiated at the sn-1 position, followed by the release of the remaining FA from the lyso-PC intermediate.	Phosphatidylcholines	100-119	lipase G, endothelial type	Homo sapiens	43-45
15834125-6	2005	The lack of phospholipase A(2) activity of EL and its ability to liberate [(14)C]FA from [(14)C]lysophosphatidylcholine (lyso-PC) led us to conclude that EL-mediated deacylation of phosphatidylcholine (PC) is initiated at the sn-1 position, followed by the release of the remaining FA from the lyso-PC intermediate.	Phosphatidylcholines	126-128	lipase G, endothelial type	Homo sapiens	43-45
15834125-1	2005	We assessed the ability of endothelial lipase (EL) to hydrolyze the sn-1 and sn-2 fatty acids (FAs) from HDL phosphatidylcholine.	Phosphatidylcholines	109-128	lipase G, endothelial type	Homo sapiens	47-49
15829484-0	2005	Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.	Phosphatidylcholines	125-144	stearoyl-Coenzyme A desaturase 1	Mus musculus	0-25
15966743-2	2005	When 100% phosphatidylcholine (PC) in standard vesicles was gradually replaced with either DG or PE, the stability of CYP1A2 increased; the incubation time-dependent destruction of spectrally detectable P450, decrease of catalytic activity, reduction of intrinsic fluorescence, and increased sensitivity to trypsin digestion were significantly alleviated.	Phosphatidylcholines	10-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124
15966743-2	2005	When 100% phosphatidylcholine (PC) in standard vesicles was gradually replaced with either DG or PE, the stability of CYP1A2 increased; the incubation time-dependent destruction of spectrally detectable P450, decrease of catalytic activity, reduction of intrinsic fluorescence, and increased sensitivity to trypsin digestion were significantly alleviated.	Phosphatidylcholines	31-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124
15953354-5	2005	Overexpression of EL resulted in enhanced hydrolysis of extracellular high-density lipoprotein (HDL)-associated sn-2-labeled [(14)C]20 : 4 phosphatidylcholine.	Phosphatidylcholines	139-158	lipase G, endothelial type	Homo sapiens	18-20
15829484-4	2005	The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice.	Phosphatidylcholines	15-34	stearoyl-Coenzyme A desaturase 1	Mus musculus	260-264
15829484-4	2005	The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice.	Phosphatidylcholines	36-38	stearoyl-Coenzyme A desaturase 1	Mus musculus	260-264
15829484-8	2005	The incorporation of [(3)H]glycerol into PC was increased by 2.5-fold in Scd1-/- primary hepatocytes compared with those of wild type mice.	Phosphatidylcholines	41-43	stearoyl-Coenzyme A desaturase 1	Mus musculus	73-77
15829484-10	2005	Our study revealed that SCD1 deficiency specifically increases CCT activity by promoting its translocation into membrane and enhances PC biosynthesis in liver.	Phosphatidylcholines	134-136	stearoyl-Coenzyme A desaturase 1	Mus musculus	24-28
15938614-7	2005	Alpha-synuclein deficiency decreased the incorporation rate and fractional turnover of 16:0 in a number of phospholipid classes, but also increased the incorporation rate and fractional turnover of 16:0 in the choline glycerophospholipids.	Phosphatidylcholines	210-238	synuclein, alpha	Mus musculus	0-15
15788406-0	2005	Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	19-38	mitogen-activated protein kinase 1	Homo sapiens	53-56
15788406-6	2005	Expression of truncated CCTalpha mutants lacking proline-directed sites within the C-terminal phosphorylation domain partially blocked oxysterol-mediated inhibition of PtdCho synthesis.	Phosphatidylcholines	168-174	phosphate cytidylyltransferase 1A, choline	Homo sapiens	24-32
15788406-7	2005	Mutagenesis of Ser315 within CCTalpha was both required and sufficient to confer significant resistance to 22-HC/9-cis-RA inhibition of PtdCho synthesis.	Phosphatidylcholines	136-142	phosphate cytidylyltransferase 1A, choline	Homo sapiens	29-37
15772421-8	2005	These results demonstrate that LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate PtdCho metabolism in pulmonary epithelia.	Phosphatidylcholines	140-146	ceramide synthase 5	Homo sapiens	31-36
15617515-3	2005	Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p.	Phosphatidylcholines	152-171	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	38-43
15806137-5	2005	The complementary nature of the fatty acid alterations in CL and PC suggested that fatty acid transfer between these two lipids was inhibited in BTHS.	Phosphatidylcholines	65-67	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	145-149
15949677-3	2005	In this report, we studied the synergistic antioxidant role of zeaxanthin and GSTP1 in egg yolk phosphatidylcholine (EYPC) liposomes using hydrophilic 2,2"-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) and lipophilic 2,2"-azobis(2,4-dimethylvaleronitrile) (AMVN) as lipid peroxyl radical generators.	Phosphatidylcholines	96-115	glutathione S-transferase pi 1	Homo sapiens	78-83
15713672-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) is a multi-domain enzyme that regulates phosphatidylcholine synthesis.	Phosphatidylcholines	86-105	CCT	Homo sapiens	41-44
15628972-2	2005	PC-TP (phosphatidylcholine transfer protein) is a START (steroidogenic acute regulatory protein-related lipid transfer) domain protein that catalyses the intermembrane transfer of phosphatidylcholines and promotes apolipoprotein AI-mediated lipid efflux when overexpressed in the cytosol of Chinese-hamster ovary cells.	Phosphatidylcholines	180-200	phosphatidylcholine transfer protein	Cricetulus griseus	0-5
15628972-2	2005	PC-TP (phosphatidylcholine transfer protein) is a START (steroidogenic acute regulatory protein-related lipid transfer) domain protein that catalyses the intermembrane transfer of phosphatidylcholines and promotes apolipoprotein AI-mediated lipid efflux when overexpressed in the cytosol of Chinese-hamster ovary cells.	Phosphatidylcholines	180-200	apolipoprotein A-I	Cricetulus griseus	214-231
15617515-3	2005	Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p.	Phosphatidylcholines	152-171	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	189-195
15516491-7	2005	Phosphatidylcholine, the major phospholipid in surfactant and the greatest potential source for generation of lysophospholipids, was susceptible to hydrolysis by group IB, group V, and group X sPLA(2)s, but not group IIA or IID.	Phosphatidylcholines	0-19	phospholipase A2 group IID	Homo sapiens	193-201
15588231-6	2005	At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)&gt;PtdIns&gt;PtdCho (phosphatidylcholine&gt;PtdEtn (phosphatidylethanolamine).	Phosphatidylcholines	135-154	lysophospholipase	Saccharomyces cerevisiae S288C	67-72
15588231-6	2005	At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)&gt;PtdIns&gt;PtdCho (phosphatidylcholine&gt;PtdEtn (phosphatidylethanolamine).	Phosphatidylcholines	135-154	lysophospholipase	Saccharomyces cerevisiae S288C	77-82
15863370-2	2005	Such modification of the molecular species of these lipid classes requires deacylation and reacylation reactions and for phosphatidylcholines, lysophosphatidylcholine acyltransferase (LPCAT) and a coenzyme A-independent transacylase (CoAIT) can each be involved.	Phosphatidylcholines	121-141	lysophosphatidylcholine acyltransferase 1	Homo sapiens	143-182
15863370-3	2005	Since previous studies have shown a significant IFNgamma- and TNFalpha-induced modification of phosphatidylcholine species, we have examined whether these inflammatory cytokines alter the activity of reacylation enzymes in the human monocyte cell line MonoMac 6 (MM6).	Phosphatidylcholines	95-114	tumor necrosis factor	Homo sapiens	62-70
15846601-1	2005	BACKGROUND: CDP-choline (cytidine 5"-diphosphocholine) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischaemia to free fatty acids and free radicals.	Phosphatidylcholines	101-120	cut like homeobox 1	Homo sapiens	12-15
15794656-3	2005	Insertion of TH1 into large unilamellar phosphatidylcholine vesicles was followed by monitoring tryptophan fluorescence.	Phosphatidylcholines	40-59	negative elongation factor complex member C/D	Homo sapiens	13-16
15772346-0	2005	Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.	Phosphatidylcholines	78-97	swiss cheese	Drosophila melanogaster	8-20
15736058-9	2005	We have confirmed the presence of PC in the lower joint cavity of rat TMJs as well as on the mandibular condylar surface layer, which was colocalized with hyaluronic acid and fibronectin respectively.	Phosphatidylcholines	34-36	fibronectin 1	Rattus norvegicus	175-186
15798219-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	103-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
15798219-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	103-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
15798219-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	124-130	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
15798219-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	124-130	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
15692104-2	2005	METHODS AND RESULTS: We found that CRP and annexin A5 at physiological concentrations bind Ca++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL.	Phosphatidylcholines	120-139	C-reactive protein	Homo sapiens	35-38
15692104-2	2005	METHODS AND RESULTS: We found that CRP and annexin A5 at physiological concentrations bind Ca++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL.	Phosphatidylcholines	120-139	annexin A5	Homo sapiens	43-53
16010981-6	2005	During receptor-coupled cell activation, phospholipase A2 (PLA2) converts PC and PA to lysoPC and lysoPA, respectively; PI is converted to PIP2 by successive enzymatic phosphorylation by PI 4-kinase and PIP 5-kinase; and phospholipase C (PLC) degrades PIP2 to diacylglycerol and inositol 1,4,5-trisphosphate.	Phosphatidylcholines	74-76	LOC104974671	Bos taurus	41-57
16010981-6	2005	During receptor-coupled cell activation, phospholipase A2 (PLA2) converts PC and PA to lysoPC and lysoPA, respectively; PI is converted to PIP2 by successive enzymatic phosphorylation by PI 4-kinase and PIP 5-kinase; and phospholipase C (PLC) degrades PIP2 to diacylglycerol and inositol 1,4,5-trisphosphate.	Phosphatidylcholines	74-76	LOC104974671	Bos taurus	59-63
15772346-0	2005	Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.	Phosphatidylcholines	78-97	patatin like phospholipase domain containing 6	Homo sapiens	21-47
15772346-3	2005	NTE reacts with organophosphate compounds that cause a paralyzing axonal degeneration in humans and has been shown to degrade endoplasmic reticulum-associated phosphatidylcholine (PtdCho) in cultured mammalian cells.	Phosphatidylcholines	180-186	patatin like phospholipase domain containing 6	Homo sapiens	0-3
15618226-4	2005	Based on amino acid sequence similarity to a bacterial phosphatidylcholine-hydrolyzing phospholipase C, six putative phospholipase Cs were identified in the Arabidopsis genome, one of which, NPC4, showed significant transcriptional activation upon phosphate limitation.	Phosphatidylcholines	55-74	phospholipase C1	Arabidopsis thaliana	87-102
15611060-0	2005	Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p.	Phosphatidylcholines	30-49	lysophospholipase	Saccharomyces cerevisiae S288C	0-5
15611060-0	2005	Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p.	Phosphatidylcholines	30-49	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	78-84
15611060-3	2005	Nte1p, the product of open reading frame YML059c, is an integral membrane phospholipase against CDP-Cho-derived PC producing intracellular glycerophosphocholine (GPCho) and free fatty acids.	Phosphatidylcholines	112-114	lysophospholipase	Saccharomyces cerevisiae S288C	0-5
15611060-6	2005	Instead, newly synthesized PC was degraded by phospholipase D (Spo14p).	Phosphatidylcholines	27-29	phospholipase D	Saccharomyces cerevisiae S288C	46-61
15611060-6	2005	Instead, newly synthesized PC was degraded by phospholipase D (Spo14p).	Phosphatidylcholines	27-29	phospholipase D	Saccharomyces cerevisiae S288C	63-69
15618226-4	2005	Based on amino acid sequence similarity to a bacterial phosphatidylcholine-hydrolyzing phospholipase C, six putative phospholipase Cs were identified in the Arabidopsis genome, one of which, NPC4, showed significant transcriptional activation upon phosphate limitation.	Phosphatidylcholines	55-74	non-specific phospholipase C4	Arabidopsis thaliana	191-195
15611060-9	2005	Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p.	Phosphatidylcholines	60-62	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	102-108
15618226-0	2005	A novel phosphatidylcholine-hydrolyzing phospholipase C induced by phosphate starvation in Arabidopsis.	Phosphatidylcholines	8-27	phospholipase C1	Arabidopsis thaliana	40-55
15618226-2	2005	We report a novel phospholipase C that hydrolyzes phosphatidylcholine and is greatly induced in response to phosphate deprivation in Arabidopsis.	Phosphatidylcholines	50-69	phospholipase C1	Arabidopsis thaliana	18-33
15611060-9	2005	Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p.	Phosphatidylcholines	60-62	lysophospholipase	Saccharomyces cerevisiae S288C	110-115
15618226-5	2005	Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity.	Phosphatidylcholines	102-121	non-specific phospholipase C4	Arabidopsis thaliana	47-51
15611060-9	2005	Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p.	Phosphatidylcholines	60-62	phospholipase D	Saccharomyces cerevisiae S288C	134-140
15618226-3	2005	Since phosphatidylcholine-hydrolyzing activity by phospholipase C was highly up-regulated in phosphate-deprived plants, gene expression of some phospholipase C was expected to be induced during phosphate starvation.	Phosphatidylcholines	6-25	phospholipase C1	Arabidopsis thaliana	50-65
15618226-3	2005	Since phosphatidylcholine-hydrolyzing activity by phospholipase C was highly up-regulated in phosphate-deprived plants, gene expression of some phospholipase C was expected to be induced during phosphate starvation.	Phosphatidylcholines	6-25	phospholipase C1	Arabidopsis thaliana	144-159
15611060-9	2005	Furthermore, our analyses revealed a profound alteration of PC metabolism triggered by the absence of Sec14p: Nte1p unresponsiveness, Spo14p activation, and deregulation of Pct1p.	Phosphatidylcholines	60-62	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	173-178
15618226-5	2005	Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity.	Phosphatidylcholines	102-121	non-specific phospholipase C4	Arabidopsis thaliana	71-75
15618226-5	2005	Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca(2+) for its activity.	Phosphatidylcholines	102-121	phospholipase C1	Arabidopsis thaliana	134-149
15618226-7	2005	Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation.	Phosphatidylcholines	102-121	non-specific phospholipase C4	Arabidopsis thaliana	35-39
15618226-7	2005	Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation.	Phosphatidylcholines	102-121	non-specific phospholipase C4	Arabidopsis thaliana	76-80
15618226-7	2005	Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation.	Phosphatidylcholines	102-121	phospholipase C1	Arabidopsis thaliana	134-149
15611060-12	2005	Beyond the new PC metabolic control features we ascribe to Sfh2p and Sfh4p we also describe a second role for Sec14p in mediating PC homeostasis.	Phosphatidylcholines	15-17	Csr1p	Saccharomyces cerevisiae S288C	59-64
15576839-1	2005	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	157-177	phosphatidylcholine transfer protein	Mus musculus	0-36
15611060-12	2005	Beyond the new PC metabolic control features we ascribe to Sfh2p and Sfh4p we also describe a second role for Sec14p in mediating PC homeostasis.	Phosphatidylcholines	130-132	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	110-116
15728476-12	2005	Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression.	Phosphatidylcholines	72-91	CD38 antigen	Mus musculus	27-31
15728476-12	2005	Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression.	Phosphatidylcholines	72-91	CD38 antigen	Mus musculus	194-198
15728476-12	2005	Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression.	Phosphatidylcholines	72-91	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	231-244
15576839-1	2005	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	157-177	phosphatidylcholine transfer protein	Mus musculus	38-43
15728476-12	2005	Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression.	Phosphatidylcholines	72-91	cyclin D2	Mus musculus	262-271
15635091-2	2005	Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	245-264	choline-phosphate cytidylyltransferase A	Cricetulus griseus	119-164
15728476-12	2005	Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IkappaB-alpha degradation, and cyclin-D2 expression.	Phosphatidylcholines	93-95	CD38 antigen	Mus musculus	27-31
15635091-2	2005	Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	245-264	choline-phosphate cytidylyltransferase A	Cricetulus griseus	166-174
15635091-2	2005	Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	266-272	choline-phosphate cytidylyltransferase A	Cricetulus griseus	119-164
15635091-2	2005	Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis.	Phosphatidylcholines	266-272	choline-phosphate cytidylyltransferase A	Cricetulus griseus	166-174
15754464-4	2005	Plasma PLTP activity was assayed by measuring the transfer of radiolabeled phosphatidylcholine from liposomes to HDL and high-sensitivity C-reactive protein (CRP) by immunoturbidimetric assay in 280 type 2 diabetic patients and 105 controls.	Phosphatidylcholines	75-94	phospholipid transfer protein	Homo sapiens	7-11
15550377-0	2005	Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.	Phosphatidylcholines	41-60	ATP-binding cassette, sub-family A (ABC1), member 7	Mus musculus	0-5
15686962-1	2005	BACKGROUND AND PURPOSE: Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial effects in a number of CNS injury models including cerebral ischemia.	Phosphatidylcholines	121-140	cut-like homeobox 1	Rattus norvegicus	68-71
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylcholines	174-193	synaptotagmin 1	Homo sapiens	117-132
15607900-4	2005	We originally reported that PON1 had phospholipase activity toward oxidized phosphatidylcholine (J. Biol.	Phosphatidylcholines	76-95	paraoxonase 1	Homo sapiens	28-32
15607900-17	2005	PON1 preparations free of PAF-AH activity showed no phospholipase activity when reconstituted into apolipoprotein AI-phosphatidylcholine complexes.	Phosphatidylcholines	117-136	apolipoprotein A1	Homo sapiens	99-116
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylcholines	174-193	secretoglobin family 2B member 3, pseudogene	Homo sapiens	134-137
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylcholines	195-197	synaptotagmin 1	Homo sapiens	117-132
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylcholines	195-197	secretoglobin family 2B member 3, pseudogene	Homo sapiens	134-137
15628842-9	2005	EPR spectroscopy indicates that the C2B domain has different interactions with PC/PS membranes containing 1 mol % phosphatidylinositol 4,5-bisphosphate.	Phosphatidylcholines	79-81	secretoglobin family 2B member 3, pseudogene	Homo sapiens	36-39
15652523-4	2005	Fluorescence analyses demonstrated that the BODIPY fatty acid--albumin complex was translocated into the lens, where the BODIPY fatty acid was incorporated in a time dependent manner into numerous lipids, including phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin.	Phosphatidylcholines	215-234	albumin	Homo sapiens	63-70
15588906-5	2005	We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	194-213	fibronectin 1	Homo sapiens	108-119
15588906-5	2005	We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	194-213	fibronectin 1	Homo sapiens	121-123
15588906-5	2005	We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	215-217	fibronectin 1	Homo sapiens	108-119
15588906-5	2005	We have therefore used fluorescence resonance energy transfer (FRET) to measure changes in the structure of fibronectin (Fn)--a key serum protein involved in phagocytosis--upon interaction with phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	215-217	fibronectin 1	Homo sapiens	121-123
15665518-5	2005	PLD-catalyzed conversion of phosphatidylcholine to phosphatydilethanol (PetOH), in the presence of ethanol, was monitored by thin layer chromatography.	Phosphatidylcholines	28-47	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
15501933-3	2005	Octylglucoside-solubilized rhodopsin was incorporated by detergent dilution into solid-supported bilayers composed either of egg phosphatidylcholine or various mixtures of a nonlamellar-forming lipid (dioleoylphosphatidylethanolamine; DOPE) together with a lamellar-forming lipid (dioleoylphosphatidylcholine; DOPC).	Phosphatidylcholines	129-148	rhodopsin	Homo sapiens	27-36
15956784-0	2005	C2C12 skeletal muscle cells exposure to phosphatidylcholine triggers IGF-1 like-responses.	Phosphatidylcholines	40-59	insulin-like growth factor 1	Mus musculus	69-74
16127297-0	2005	Anionic peptide factor/phosphatidylcholine particles promote the inhibition of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells.	Phosphatidylcholines	23-42	vascular cell adhesion molecule 1	Homo sapiens	79-112
16055952-2	2005	PC synthesis is controlled by cellular levels of its precursor, cytidine-5"-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine.	Phosphatidylcholines	0-2	cut-like homeobox 1	Rattus norvegicus	97-100
15756928-5	2005	CDP-choline might increase the PC levels by attenuating PLA(2) stimulation and loss of CCT activity.	Phosphatidylcholines	31-33	cut like homeobox 1	Homo sapiens	0-3
15756928-5	2005	CDP-choline might increase the PC levels by attenuating PLA(2) stimulation and loss of CCT activity.	Phosphatidylcholines	31-33	phospholipase A2 group IB	Homo sapiens	56-62
16127297-5	2005	METHODS: We examined the effects of two HDL apolipoproteins A-I and APF, either in presence or absence of phosphatidylcholines (PCs), or free PCs, on the expression of VCAM-1 by HUVEC.	Phosphatidylcholines	106-126	vascular cell adhesion molecule 1	Homo sapiens	168-174
15475361-1	2004	Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes.	Phosphatidylcholines	67-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-26
15498769-0	2004	Increased phosphatidylcholine production but disrupted glycogen metabolism in fetal type II cells of mice that overexpress CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	10-29	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	123-162
15498769-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	103-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
15498769-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	103-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
15498769-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	124-130	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
15498769-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in the de novo synthesis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	124-130	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
15475361-1	2004	Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes.	Phosphatidylcholines	67-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	28-31
15385540-1	2004	Homeostasis of phosphatidylcholine (PC) is regulated by the opposing actions between CTP:phosphocholine cytidylyltransferase (CT) and the group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)).	Phosphatidylcholines	15-34	phospholipase A2 group VI	Homo sapiens	187-194
15385540-1	2004	Homeostasis of phosphatidylcholine (PC) is regulated by the opposing actions between CTP:phosphocholine cytidylyltransferase (CT) and the group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)).	Phosphatidylcholines	36-38	phospholipase A2 group VI	Homo sapiens	187-194
15385540-6	2004	The accumulation of PC correlates with decreased iPLA(2) activity, suggesting that regulation of this enzyme contributes to phospholipid accumulation.	Phosphatidylcholines	20-22	phospholipase A2 group VI	Homo sapiens	49-56
15522829-8	2004	Taken together with our previous observations that both Abeta peptides may induce hydrolysis of phosphatidylcholine, the present results provide evidence that this process is cooperatively mediated by cPLA(2) activation/translocation and iPLA(2) activation.	Phosphatidylcholines	96-115	phospholipase A2 group IVA	Bos taurus	201-208
15310557-1	2004	C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system.	Phosphatidylcholines	61-80	C-reactive protein	Bos taurus	0-18
15310557-1	2004	C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system.	Phosphatidylcholines	61-80	C-reactive protein	Bos taurus	20-23
15310557-1	2004	C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system.	Phosphatidylcholines	61-80	pulmonary surfactant-associated protein A	Bos taurus	29-49
15310557-1	2004	C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system.	Phosphatidylcholines	61-80	pulmonary surfactant-associated protein A	Bos taurus	51-55
15310557-9	2004	These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films.	Phosphatidylcholines	60-62	pulmonary surfactant-associated protein A	Bos taurus	37-41
15310557-9	2004	These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films.	Phosphatidylcholines	60-62	C-reactive protein	Bos taurus	46-49
15466370-1	2004	The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected.	Phosphatidylcholines	158-177	lecithin-cholesterol acyltransferase	Homo sapiens	74-78
15466370-1	2004	The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected.	Phosphatidylcholines	179-181	lecithin-cholesterol acyltransferase	Homo sapiens	74-78
15466370-2	2004	To explain these discrepancies, we proposed that LCAT transfers some saturated fatty acids from the sn-1 position of PC species that contain 20:4 or 22:6 at sn-2.	Phosphatidylcholines	117-119	lecithin-cholesterol acyltransferase	Homo sapiens	49-53
15322105-8	2004	Phosphorylated PITPalpha was unable to deliver its PI cargo, although it could deliver phosphatidylcholine.	Phosphatidylcholines	87-106	phosphatidylinositol transfer protein alpha	Homo sapiens	15-24
15569411-4	2004	(2) VIP (10(-8) mol/L) enhanced the contents of total phospholipids and phosphatidylcholine in lung explants.	Phosphatidylcholines	72-91	vasoactive intestinal peptide	Homo sapiens	4-7
15569411-8	2004	CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway.	Phosphatidylcholines	43-62	vasoactive intestinal peptide	Homo sapiens	12-15
15569411-8	2004	CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway.	Phosphatidylcholines	43-62	phosphate cytidylyltransferase 1A, choline	Homo sapiens	150-158
15569411-8	2004	CONCLUSION: VIP could enhance synthesis of phosphatidylcholine, the major component of pulmonary surfactants by enhancing microsomal CCT activity and CCTalpha mRNA level via VIP receptor-mediated pathway.	Phosphatidylcholines	43-62	vasoactive intestinal peptide	Homo sapiens	174-177
15522822-0	2004	Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha.	Phosphatidylcholines	85-104	phosphatidylinositol transfer protein alpha	Homo sapiens	108-151
15522822-1	2004	Mammalian phosphatidylinositol transfer protein alpha (PITP) is an intracellular lipid transporter with a binding site that can accommodate a single molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC).	Phosphatidylcholines	190-209	phosphatidylinositol transfer protein alpha	Homo sapiens	10-53
15522822-1	2004	Mammalian phosphatidylinositol transfer protein alpha (PITP) is an intracellular lipid transporter with a binding site that can accommodate a single molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC).	Phosphatidylcholines	211-213	phosphatidylinositol transfer protein alpha	Homo sapiens	10-53
15522822-5	2004	Lipids extracted from the PITPalpha were analysed by tandem electrospray ionisation mass spectrometry (ESI-MS) and showed total exchange of acquired bacterial lipids for HL60 cellular PI and PC.	Phosphatidylcholines	191-193	phosphatidylinositol transfer protein alpha	Homo sapiens	26-35
15522832-7	2004	PtdEtn formed by Psd2p is the preferred substrate for PtdCho synthesis.	Phosphatidylcholines	54-60	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	17-22
15560781-3	2004	The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis).	Phosphatidylcholines	102-121	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	4-8
15481031-2	2004	We have used atomic force microscopy (AFM) to study the interaction of synapsin I with negatively charged lipid domains in phase-separated supported lipid bilayers prepared from mixtures of phosphatidylcholines (PCs) and phosphatidylserines (PSs).	Phosphatidylcholines	190-210	synapsin I	Homo sapiens	71-81
15331603-1	2004	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	125-144	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
15331603-1	2004	CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	125-144	cut-like homeobox 1	Mus musculus	81-84
15331603-2	2004	Hepatic cells express both an alpha and a beta2 isoform of CT and can also synthesize phosphatidylcholine via the sequential methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase.	Phosphatidylcholines	86-105	histocompatibility 2, O region beta locus	Mus musculus	40-47
15331603-6	2004	The plasma phosphatidylcholine concentration was reduced in the CTalpha knockout (independent of gender), as were levels of high density lipoproteins (cholesterol and apoAI) and very low density lipoproteins (triacylglycerols and apoB100).	Phosphatidylcholines	11-30	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	64-71
15560781-3	2004	The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis).	Phosphatidylcholines	123-129	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	4-8
15560781-3	2004	The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis).	Phosphatidylcholines	331-337	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	4-8
15466483-2	2004	Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane.	Phosphatidylcholines	188-207	X-box binding protein 1	Homo sapiens	44-48
15308634-0	2004	Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release.	Phosphatidylcholines	214-233	glutathione peroxidase 4	Homo sapiens	18-67
15308634-0	2004	Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release.	Phosphatidylcholines	214-233	matrix metallopeptidase 1	Homo sapiens	169-195
15466483-2	2004	Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane.	Phosphatidylcholines	188-207	X-box binding protein 1	Homo sapiens	76-80
15466483-2	2004	Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient to induce synthesis of phosphatidylcholine, the primary phospholipid of the ER membrane.	Phosphatidylcholines	188-207	X-box binding protein 1	Homo sapiens	76-80
15466483-3	2004	Cells overexpressing XBP1(S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the cytidine diphosphocholine pathway of phosphatidylcholine biosynthesis.	Phosphatidylcholines	193-212	X-box binding protein 1	Homo sapiens	21-25
15280390-0	2004	Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36.	Phosphatidylcholines	42-61	scavenger receptor class B member 1	Homo sapiens	114-148
15294901-3	2004	Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	94-113	phospholipase A2, group XV	Mus musculus	28-54
15294901-3	2004	Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	94-113	phospholipase A2, group XV	Mus musculus	63-68
15258140-2	2004	In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p.	Phosphatidylcholines	81-83	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	216-221
15258199-0	2004	Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.	Phosphatidylcholines	63-65	peroxisome proliferator activated receptor alpha	Homo sapiens	84-93
15258199-0	2004	Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.	Phosphatidylcholines	63-65	ATP binding cassette subfamily B member 4	Homo sapiens	121-126
15258199-8	2004	These findings suggest that BF may enhance the capacity of human hepatocytes to direct PC into bile canaliculi via PPARalpha-mediated redistribution of ABCB4 to the canalicular membrane.	Phosphatidylcholines	87-89	peroxisome proliferator activated receptor alpha	Homo sapiens	115-124
15752119-0	2004	Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii.	Phosphatidylcholines	0-19	C-C motif chemokine ligand 2	Homo sapiens	112-133
15752119-0	2004	Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii.	Phosphatidylcholines	0-19	C-C motif chemokine ligand 2	Homo sapiens	135-140
15258140-2	2004	In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p.	Phosphatidylcholines	81-83	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	226-231
15139854-1	2004	We examined the effects of the bioactive lipid, sphingosine, on the expression of the rate-limiting enzyme involved in surfactant phosphatidylcholine synthesis, CCTalpha (CTP:phosphocholine cytidylyltransferase alpha).	Phosphatidylcholines	130-149	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	171-216
15306175-1	2004	We have previously shown that intravenous apolipoprotein (apo) A-I/phosphatidylcholine (apo A-I/PC) discs increase plasma high-density lipoprotein (HDL) concentration in humans.	Phosphatidylcholines	67-86	apolipoprotein A1	Homo sapiens	88-93
15342124-0	2004	Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells.	Phosphatidylcholines	77-96	scavenger receptor class B member 1	Cricetulus griseus	0-34
15342124-2	2004	In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins.	Phosphatidylcholines	75-94	scavenger receptor class B member 1	Cricetulus griseus	45-50
15342124-2	2004	In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins.	Phosphatidylcholines	96-98	scavenger receptor class B member 1	Cricetulus griseus	45-50
15450473-3	2004	In adult lung, PTHrP stimulates disaturated phosphatidylcholine secretion, inhibits type II cell growth, and sensitizes them to apoptosis.	Phosphatidylcholines	44-63	parathyroid hormone like hormone	Homo sapiens	15-20
15306175-0	2004	Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid.	Phosphatidylcholines	42-61	paraoxonase 1	Homo sapiens	71-82
15306175-0	2004	Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid.	Phosphatidylcholines	42-61	phospholipase A2 group VII	Homo sapiens	87-129
15139854-2	2004	Sphingosine decreased phosphatidylcholine synthesis by inhibiting CCT activity in primary alveolar type II epithelia.	Phosphatidylcholines	22-41	t-complex protein 1	Mus musculus	66-69
15450206-8	2004	Phosphatidylcholine, phosphatidylethanolamine, and LPE plasmalogen (LPEP), but not choline, also activated TGF-beta1.	Phosphatidylcholines	0-19	transforming growth factor, beta 1	Rattus norvegicus	107-116
15355352-7	2004	Phosphatidylethanolamine and phosphatidic acid were shown to be also hydrolysed by AtLCAT3, although less efficiently than phosphatidylcholine.	Phosphatidylcholines	123-142	lecithin:cholesterol acyltransferase 3	Arabidopsis thaliana	83-90
15210848-3	2004	Stable overexpression of CCTalpha in lung epithelial cell lines increased rates of PC synthesis and cellular DSPC mass without altering total cellular PC content.	Phosphatidylcholines	83-85	phosphate cytidylyltransferase 1A, choline	Homo sapiens	25-33
15210848-3	2004	Stable overexpression of CCTalpha in lung epithelial cell lines increased rates of PC synthesis and cellular DSPC mass without altering total cellular PC content.	Phosphatidylcholines	111-113	phosphate cytidylyltransferase 1A, choline	Homo sapiens	25-33
15249196-0	2004	p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis.	Phosphatidylcholines	67-86	interferon induced protein 44	Homo sapiens	0-3
15175345-3	2004	In the present paper, we optimized two independent assays for the translocation of natural phosphatidylcholine (PC) to the cell surface based on the hydrolysis of outer leaflet phosphoglycerolipids by exogenous phospholipase A2 and the exchange of outer leaflet PC by a transfer protein.	Phosphatidylcholines	91-110	phospholipase A2 group IB	Homo sapiens	211-227
15249196-0	2004	p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis.	Phosphatidylcholines	67-86	mitogen-activated protein kinase 3	Homo sapiens	7-13
15175345-3	2004	In the present paper, we optimized two independent assays for the translocation of natural phosphatidylcholine (PC) to the cell surface based on the hydrolysis of outer leaflet phosphoglycerolipids by exogenous phospholipase A2 and the exchange of outer leaflet PC by a transfer protein.	Phosphatidylcholines	112-114	phospholipase A2 group IB	Homo sapiens	211-227
15249196-0	2004	p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis.	Phosphatidylcholines	67-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	24-27
15242816-3	2004	We found that addition of phosphatidylcholine-specific phospholipase D (PLD) stabilized CYP3A in this system, but that phosphatidylinositol-specific phospholipase C (PLC) was without effect.	Phosphatidylcholines	26-45	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	88-93
15670660-11	2004	The endotoxin-stimulated tumor necrosis factor-alpha release is decreased by dilinoleoylphosphatidylcholine, the active phosphatidylcholine (PC) species of polyenylphosphatidylcholine (PPC).	Phosphatidylcholines	88-107	tumor necrosis factor	Homo sapiens	25-52
15670660-11	2004	The endotoxin-stimulated tumor necrosis factor-alpha release is decreased by dilinoleoylphosphatidylcholine, the active phosphatidylcholine (PC) species of polyenylphosphatidylcholine (PPC).	Phosphatidylcholines	141-143	tumor necrosis factor	Homo sapiens	25-52
15130088-1	2004	PtdSer (phosphatidylserine) synthesis in mammalian cells occurs through the exchange of L-serine with the base moieties of phosphatidylcholine and phosphatidylethanolamine, which is catalysed by PSS (PtdSer synthase) 1 and 2 respectively.	Phosphatidylcholines	123-142	phosphatidylserine synthase 1	Homo sapiens	200-224
15255942-3	2004	In this study, we investigated whether inhibition by ethanol of this signal transduction pathway in 1321N1 human astrocytoma cells may be due, at least in part, to inhibition of the formation of the PKC zeta activator phosphatidic acid (PA), which is formed by hydrolysis of phosphatidylcholine by phospholipase D (PLD).	Phosphatidylcholines	275-294	protein kinase C zeta	Homo sapiens	199-207
15298909-2	2004	We used a well-characterized peptide corresponding to the basic effector domain of myristoylated alanine-rich C kinase substrate, MARCKS(151-175), that was fluorescently labeled with Alexa488, and measured its binding to large unilamellar vesicles (diameter approximately 100 nm) composed of phosphatidylcholine and phosphatidylserine or phosphatidylinositol 4,5-bisphosphate.	Phosphatidylcholines	292-311	myristoylated alanine rich protein kinase C substrate	Homo sapiens	130-136
15225629-0	2004	The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast.	Phosphatidylcholines	84-103	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	125-130
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Phosphatidylcholines	81-100	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Phosphatidylcholines	81-100	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Phosphatidylcholines	102-104	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Phosphatidylcholines	102-104	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
15225629-0	2004	The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast.	Phosphatidylcholines	84-103	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	135-140
15225629-1	2004	In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	180-199	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	47-52
15225629-1	2004	In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	180-199	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	57-62
15225629-1	2004	In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	201-203	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	47-52
15225629-1	2004	In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively.	Phosphatidylcholines	201-203	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	57-62
15225629-3	2004	Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo.	Phosphatidylcholines	37-39	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	131-136
15225629-3	2004	Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo.	Phosphatidylcholines	37-39	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	141-146
15225629-3	2004	Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo.	Phosphatidylcholines	116-118	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	131-136
15225629-3	2004	Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo.	Phosphatidylcholines	116-118	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	141-146
15220446-2	2004	We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine.	Phosphatidylcholines	125-144	phospholipase A2 group IB	Homo sapiens	21-37
15236176-5	2004	The gastric injury induced by aspirin/HCl in cyclooxygenase-1 knockout mice could be prevented if the animals were treated with phosphatidylcholine-associated aspirin.	Phosphatidylcholines	128-147	prostaglandin-endoperoxide synthase 1	Mus musculus	45-61
15272209-5	2004	Long-term pretreatment with NE or CT-1 increased the incorporation of (3)H-myristic acid into PC, which was blocked by atenolol.	Phosphatidylcholines	94-96	cardiotrophin 1	Rattus norvegicus	34-38
15220446-2	2004	We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine.	Phosphatidylcholines	125-144	phospholipase A2 group IB	Homo sapiens	39-43
15231944-3	2004	After the first case, we hypothesized that abnormally high BA levels could have reversed the action of phospholipase A2 in the lungs, causing a degradation of phosphatidylcholines to lysophosphatidylcholines and the consequent lack of surfactant activity, leading to the severe respiratory distress.	Phosphatidylcholines	159-179	phospholipase A2 group IB	Homo sapiens	103-119
15202762-1	2004	Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	48-64
15202762-1	2004	Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	66-70
15202762-1	2004	Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation.	Phosphatidylcholines	30-33	phospholipase A2 group IB	Homo sapiens	48-64
15202762-1	2004	Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation.	Phosphatidylcholines	30-33	phospholipase A2 group IB	Homo sapiens	66-70
15455713-0	2004	[Bromoacyl analogues of phosphatidylcholine with intramolecular fluorescence quenching and their use as substrates for continuous monitoring of phospholipase A2 activity].	Phosphatidylcholines	24-43	phospholipase A2 group IB	Homo sapiens	144-160
15020600-2	2004	Using a series of deletion mutants lacking different regions along the molecule, we examined the contribution of alpha-helix formation in apoA-I to the binding to egg phosphatidylcholine (PC) small unilamellar vesicles (SUV).	Phosphatidylcholines	167-186	apolipoprotein A1	Homo sapiens	138-144
15044461-0	2004	Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells.	Phosphatidylcholines	59-78	patatin like phospholipase domain containing 6	Homo sapiens	0-26
15024002-9	2004	Rather, there was a trend toward increased phosphatidylcholine synthesis that might be explained by enhanced CTP:phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	43-62	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	109-148
15246991-4	2004	CDP-choline is a well-known intermediate in the biosynthesis of phosphatidylcholine, a phospholipid essential for neuronal membrane preservation and function; thus, this compound would attenuate the process of neuronal aging.	Phosphatidylcholines	64-83	cut-like homeobox 1	Mus musculus	0-3
14996830-1	2004	Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC), a bacterial model for the catalytic domain of mammalian PI-PLC enzymes, was cross-linked by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride to probe for the aggregation and/or conformational changes of PI-PLC when bound to activating phosphatidylcholine (PC) interfaces.	Phosphatidylcholines	325-344	phospholipase C beta 1	Homo sapiens	23-68
14996830-0	2004	Cross-linking phosphatidylinositol-specific phospholipase C traps two activating phosphatidylcholine molecules on the enzyme.	Phosphatidylcholines	81-100	phospholipase C beta 1	Homo sapiens	14-59
14996830-1	2004	Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC), a bacterial model for the catalytic domain of mammalian PI-PLC enzymes, was cross-linked by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride to probe for the aggregation and/or conformational changes of PI-PLC when bound to activating phosphatidylcholine (PC) interfaces.	Phosphatidylcholines	325-344	phospholipase C beta 1	Homo sapiens	70-76
15165145-7	2004	The compound showed high reactivity with 1,1-diphenyl-2-picryl hydrazyl (DPPH), IC(50) of 84.0 +/- 7.8 microM, inhibited myeloperoxidase activity with K(0.5) = 86 +/- 9.9 microM, and decreased lipid peroxidation, induced by ascorbyl radical either in microsomes or in asolectin and phosphatidylcholine liposomes, with IC(50)"s of 320 +/- 14.1, 223 +/- 8.3, and 112 +/- 8.8 microM, respectively.	Phosphatidylcholines	282-301	myeloperoxidase	Rattus norvegicus	121-136
14751545-3	2004	Tyrosine kinase inhibitor (genistein), phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D-609) and PKC inhibitor (GF109203X) attenuated TNF-alpha-induced COX-2 expression and PGE2 synthesis in HTSMCs.	Phosphatidylcholines	39-58	tumor necrosis factor	Homo sapiens	152-161
14754909-3	2004	Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P &lt; 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P &lt; 0.0001).	Phosphatidylcholines	70-89	selectin P ligand	Homo sapiens	103-106
15079868-1	2004	Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia.	Phosphatidylcholines	97-116	cut like homeobox 1	Homo sapiens	30-33
15079868-1	2004	Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia.	Phosphatidylcholines	118-124	cut like homeobox 1	Homo sapiens	30-33
15079868-3	2004	Phospholipase A(2) (PLA(2)) hydrolyzes PtdCho to produce free fatty acids and lyso-PtdCho, an inhibitor of CCT.	Phosphatidylcholines	39-45	phospholipase A2 group IB	Homo sapiens	0-18
15079868-3	2004	Phospholipase A(2) (PLA(2)) hydrolyzes PtdCho to produce free fatty acids and lyso-PtdCho, an inhibitor of CCT.	Phosphatidylcholines	39-45	phospholipase A2 group IB	Homo sapiens	20-26
15003397-1	2004	Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+).	Phosphatidylcholines	116-135	cut like homeobox 1	Homo sapiens	72-75
15003397-1	2004	Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+).	Phosphatidylcholines	137-139	cut like homeobox 1	Homo sapiens	72-75
14976195-7	2004	WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide.	Phosphatidylcholines	201-220	sphingomyelin synthase 1	Mus musculus	33-37
14976195-7	2004	WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide.	Phosphatidylcholines	201-220	sphingomyelin synthase 1	Mus musculus	50-58
14761980-9	2004	Concentrations of ATPe effective in inducing cell death also increase phosphatidylcholine-hydrolyzing phospholipase D (PC-PLD) activity in BALB/c thymocytes through the stimulation of P2X7R.	Phosphatidylcholines	70-89	ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit	Mus musculus	18-22
15065867-9	2004	(v) The SP-A2 variant (1A(0)) and the coexpressed protein 1A(0)/6A(2) inhibit ATP-stimulated PC secretion from alveolar type II cells to a greater extent than SP-A1 (6A(2)), a biologic activity that was susceptible to ozone treatment.	Phosphatidylcholines	93-95	surfactant protein A2	Homo sapiens	8-13
15049706-5	2004	Sedimentation assays using mixed phosphatidylserine/phosphatidylcholine (PS/PC) vesicles confirmed that the C2C domains of tricalbin 1 and 3 bind membranes in a calcium-responsive manner and showed that they are more sensitive to calcium than the C2A domain of synaptotagmin I.	Phosphatidylcholines	52-71	tricalbin	Saccharomyces cerevisiae S288C	123-132
14754909-3	2004	Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P &lt; 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P &lt; 0.0001).	Phosphatidylcholines	70-89	selectin P ligand	Homo sapiens	126-129
15079868-10	2004	These data indicate that PtdCho synthesis is impaired after brain ischemia, and CDP-choline may increase PtdCho levels by attenuating the loss of CCT activity and lyso-PtdCho formation.	Phosphatidylcholines	105-111	cut like homeobox 1	Homo sapiens	80-83
14752108-1	2004	Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change.	Phosphatidylcholines	20-39	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	136-168
14752108-1	2004	Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change.	Phosphatidylcholines	20-39	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	170-175
14752108-1	2004	Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change.	Phosphatidylcholines	41-43	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	136-168
14752108-1	2004	Bilayers containing phosphatidylcholine (PC) and the anionic lipid phosphatidic acid (PA) are particularly effective at stabilizing the nicotinic acetylcholine receptor (nAChR) in a functional conformation that undergoes agonist-induced conformational change.	Phosphatidylcholines	41-43	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	170-175
14752108-2	2004	The physical properties of PC membranes containing PA are also substantially altered upon incorporation of the nAChR.	Phosphatidylcholines	27-29	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	111-116
14752108-6	2004	These results show that a net negative charge alone is not sufficient to account for the unique interactions that occur between the nAChR and PC/PA membranes.	Phosphatidylcholines	142-144	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	132-137
14962950-2	2004	Group V sPLA2 is expressed in cultured macrophage cells and has high affinity for phosphatidyl choline-containing substrates.	Phosphatidylcholines	82-102	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	8-13
15294123-4	2004	Elastase and myeloperoxidase (MPO) release was measured for the parameters of neutrophil activation, neutrophil PLD activity was determined by quantitation of choline produced from the stable product of phosphatidylcholine catalyzed by PLD.	Phosphatidylcholines	203-222	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	236-239
14729861-6	2004	Prebeta LpA-I contained one to four molecules of phosphatidylcholine per molecule of apoA-I, whereas LFA-I contained less than one.	Phosphatidylcholines	49-68	apolipoprotein A-I	Mus musculus	85-91
14754909-3	2004	Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P &lt; 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P &lt; 0.0001).	Phosphatidylcholines	70-89	selectin P ligand	Homo sapiens	126-129
14754909-3	2004	Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P &lt; 0.0001) and cholesteryl ester (CE) (c9,t11 CLA r = 0.706, t10,c12 CLA r = 0.788; P &lt; 0.0001).	Phosphatidylcholines	70-89	selectin P ligand	Homo sapiens	126-129
14755582-0	2004	Exploring the interaction of the surfactant N-terminal domain of gamma-Zein with soybean phosphatidylcholine liposomes.	Phosphatidylcholines	89-108	prolamin 50 kDa gamma zein	Zea mays	65-75
15023079-3	2004	In the present study, PWR has been used to monitor the incorporation of the human beta(2)-adrenergic receptor into a solid-supported egg phosphatidylcholine lipid bilayer and to follow the binding of full agonists (isoproterenol, epinephrine), a partial agonist (dobutamine), an antagonist (alprenolol), and an inverse agonist (ICI-118,551) to the receptor.	Phosphatidylcholines	137-156	adrenoceptor beta 2	Homo sapiens	82-109
14697697-0	2004	Excluded volume effect of rat intestinal mucin on taurocholate/phosphatidylcholine mixed micelles.	Phosphatidylcholines	63-82	solute carrier family 13 member 2	Rattus norvegicus	41-46
14962392-1	2004	Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers.	Phosphatidylcholines	134-153	phosphatidylinositol transfer protein alpha	Homo sapiens	0-43
14985460-4	2004	Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	77-79	choline phosphotransferase 1	Homo sapiens	0-25
14985460-4	2004	Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	77-79	choline phosphotransferase 1	Homo sapiens	27-30
14985460-4	2004	Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	135-137	choline phosphotransferase 1	Homo sapiens	0-25
14985460-4	2004	Cholinephosphotransferase (CPT), the terminal enzyme in de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	135-137	choline phosphotransferase 1	Homo sapiens	27-30
14962392-1	2004	Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers.	Phosphatidylcholines	134-153	phosphatidylinositol transfer protein alpha	Homo sapiens	45-54
14962392-1	2004	Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers.	Phosphatidylcholines	155-157	phosphatidylinositol transfer protein alpha	Homo sapiens	0-43
14962392-1	2004	Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers.	Phosphatidylcholines	155-157	phosphatidylinositol transfer protein alpha	Homo sapiens	45-54
14698037-0	2004	COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue.	Phosphatidylcholines	40-59	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
14698037-10	2004	All together, the present results demonstrated that COX-2-mediated PGD(2) synthesis is a PC biosynthesis regulator in rat renal papilla.	Phosphatidylcholines	89-91	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	52-57
14757231-0	2004	Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1.	Phosphatidylcholines	21-40	ATP binding cassette subfamily C member 1	Homo sapiens	116-120
14757231-1	2004	Multidrug resistance-associated protein (MRP1) may function as a floppase in human red blood cells to translocate phosphatidylserine and/or phosphatidylcholine from inner membrane leaflet to outer leaflet.	Phosphatidylcholines	140-159	ATP binding cassette subfamily C member 1	Homo sapiens	0-45
14757231-2	2004	Here we report that the purified and reconstituted MRP1 protein into asolectin proteoliposomes is mainly in an inside-out configuration and possesses the ability to flop a fluorescent labeled phosphatidylcholine (NBD-PC) from outer leaflet (protoplasmic) to inner leaflet (extracytoplasmic).	Phosphatidylcholines	192-211	ATP binding cassette subfamily C member 1	Homo sapiens	51-55
14698037-5	2004	PC synthesis was highly sensitive to COX-2 inhibition, while COX-1 inhibition only reduced PC synthesis at high SC-560 concentration.	Phosphatidylcholines	0-2	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	37-42
14698037-5	2004	PC synthesis was highly sensitive to COX-2 inhibition, while COX-1 inhibition only reduced PC synthesis at high SC-560 concentration.	Phosphatidylcholines	91-93	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	61-66
14698037-7	2004	The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition.	Phosphatidylcholines	18-20	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	88-127
14698037-7	2004	The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition.	Phosphatidylcholines	18-20	cut-like homeobox 1	Rattus norvegicus	147-150
14698037-7	2004	The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition.	Phosphatidylcholines	18-20	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	88-91
15218538-5	2004	These are guanidinoacetate methyltransferase (that produces creatine) and phosphatidylethanolamine N-methyltransferase (that produces phosphatidylcholine).	Phosphatidylcholines	134-153	phosphatidylethanolamine N-methyltransferase	Homo sapiens	74-118
14592540-0	2004	Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells.	Phosphatidylcholines	33-52	cut like homeobox 1	Homo sapiens	120-123
15844632-1	2004	Lysophosphatidylcholine (lysoPC) is generated by the action of phospholipase A2 on membrane phosphatidylcholine, the most abundant cellular phospholipid.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	63-79
15319526-4	2004	Here we show that the cation-over-anion selectivity of reconstituted ICln channels can be varied by the thickness of a bilayer build of phosphatidylcholines.	Phosphatidylcholines	136-156	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	69-73
14592540-1	2004	We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	194-213	cut like homeobox 1	Homo sapiens	223-226
14592540-1	2004	We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	68-70	cut like homeobox 1	Homo sapiens	223-226
14592540-7	2004	These results constitute the first experimental evidence that the inhibition of the synthesis of PC via CDP-choline by HePC is not counterbalanced by any increase in its formation via methylation.	Phosphatidylcholines	97-99	cut like homeobox 1	Homo sapiens	104-107
14675982-2	2004	In Group A (oestrogen alone) HDL2 phosphatidylcholine increased (P&lt;0.001), while there was a decrease in HDL2 phosphatidylinositol (P&lt;0.05) and HDL2 phosphatidylethanolamine (P&lt;0.05) compared to controls (baseline).	Phosphatidylcholines	34-53	junctophilin 3	Homo sapiens	29-33
15622860-3	2004	To exemplify the method application to the membrane studies, energy transfer from anthrylvinyl-labeled phosphatidylcholine incorporated into mixed phosphatidylcholine/cardiolipin unilamellar vesicles to heme group of cytochrome c is analyzed.	Phosphatidylcholines	103-122	cytochrome c, somatic	Homo sapiens	217-229
15669680-5	2004	In the Hexb mouse, a model of Sandhoff disease, lipid phosphate levels were elevated in surfactant from 3- and 4-month-old mice, which was mainly due to elevated levels of phosphatidylcholine.	Phosphatidylcholines	172-191	hexosaminidase B	Mus musculus	7-11
15669680-6	2004	In the ASM mouse, a model of Niemann-Pick A disease, levels of the primary storage material, sphingomyelin, were elevated as expected, and levels of phosphatidylcholine and two other phospholipids were also significantly elevated in pulmonary surfactant and in lung tissue from 5-, 6- and 7-month-old mice.	Phosphatidylcholines	149-168	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	7-10
14675982-5	2004	In the same group, an increase in HDL3 phosphatidylcholine (P&lt;0.001) and a reduction in HDL3 phosphatidylinositol (P&lt;0.05) were observed as well as a decrease in HDL3 phosphatidylethanolamine (P&lt;0.01) and HDL3 diphosphatidylglycerol (P&lt;0.05).	Phosphatidylcholines	39-58	HDL3	Homo sapiens	34-38
14675982-3	2004	In the same group, HDL3 phosphatidylcholine increased (P&lt;0.001) and HDL3 phosphatidylethanolamine decreased (P&lt;0.01).	Phosphatidylcholines	24-43	HDL3	Homo sapiens	19-23
14675982-4	2004	In Group B (raloxifene) HDL2 phosphatidylcholine increased (P&lt;0.001) as well as HDL2 diphosphatidylglycerol (P&lt;0.01) while there were decreases in HDL2 sphingomyelin (P&lt;0.01) and HDL2 phosphatidylethanolamine (P&lt;0.05).	Phosphatidylcholines	29-48	junctophilin 3	Homo sapiens	24-28
14528019-2	2004	Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline.	Phosphatidylcholines	152-171	phospholipase D	Saccharomyces cerevisiae S288C	37-43
14501041-1	2004	Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline.	Phosphatidylcholines	52-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-25
14501041-1	2004	Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline.	Phosphatidylcholines	52-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
14501041-1	2004	Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline.	Phosphatidylcholines	73-75	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-25
15173620-3	2004	The assay for cPLA2alpha involves measuring the calcium-dependent release of radiolabeled sn-2 arachidonic acid from small unilamellar vesicles of phosphatidylcholine.	Phosphatidylcholines	147-166	phospholipase A2 group IVA	Homo sapiens	14-24
14528019-2	2004	Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline.	Phosphatidylcholines	152-171	phospholipase D	Saccharomyces cerevisiae S288C	112-127
14501041-1	2004	Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline.	Phosphatidylcholines	73-75	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
14528019-2	2004	Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline.	Phosphatidylcholines	173-179	phospholipase D	Saccharomyces cerevisiae S288C	37-43
14528019-2	2004	Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline.	Phosphatidylcholines	173-179	phospholipase D	Saccharomyces cerevisiae S288C	112-127
15696852-7	2004	The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile.	Phosphatidylcholines	76-95	ATP binding cassette subfamily B member 4	Homo sapiens	28-33
15517554-1	2004	Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS).	Phosphatidylcholines	60-79	protocadherin 8	Homo sapiens	54-58
15696852-7	2004	The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile.	Phosphatidylcholines	76-95	ATP binding cassette subfamily B member 4	Homo sapiens	35-39
15696852-7	2004	The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile.	Phosphatidylcholines	97-99	ATP binding cassette subfamily B member 4	Homo sapiens	28-33
15696852-7	2004	The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile.	Phosphatidylcholines	97-99	ATP binding cassette subfamily B member 4	Homo sapiens	35-39
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	102-104	choline phosphotransferase 1	Homo sapiens	0-25
14557258-1	2003	Lipoprotein(a), Lp(a), an athero-thrombotic risk factor, reacts with EO6, a natural monoclonal autoantibody that recognizes the phophorylcholine (PC) group of oxidized phosphatidylcholine (oxPtdPC) either as a lipid or linked by a Schiff base to lysine residues of peptides/proteins.	Phosphatidylcholines	168-187	lipoprotein(a)	Homo sapiens	16-21
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	81-100	choline phosphotransferase 1	Homo sapiens	0-25
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	81-100	choline phosphotransferase 1	Homo sapiens	27-30
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phosphatidylcholines	40-59	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phosphatidylcholines	40-59	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	102-104	choline phosphotransferase 1	Homo sapiens	27-30
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	161-163	choline phosphotransferase 1	Homo sapiens	0-25
14651986-1	2003	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of phosphatidylcholine (PC), has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	161-163	choline phosphotransferase 1	Homo sapiens	27-30
14646617-4	2003	Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines.	Phosphatidylcholines	27-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
14729069-1	2003	Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	168-187	phosphatidylinositol transfer protein alpha	Homo sapiens	0-43
14729069-1	2003	Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	168-187	phosphatidylinositol transfer protein alpha	Homo sapiens	45-55
14729069-1	2003	Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	189-195	phosphatidylinositol transfer protein alpha	Homo sapiens	0-43
14729069-1	2003	Phosphatidylinositol transfer protein alpha (PITP-alpha) is a bifunctional phospholipid transfer protein that is highly selective for phosphatidylinositol (PtdIns) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	189-195	phosphatidylinositol transfer protein alpha	Homo sapiens	45-55
14729069-3	2003	In this study, polar lipid metabolites of PtdIns and PtdCho were tested for their ability to influence PITP-alpha activity.	Phosphatidylcholines	53-59	phosphatidylinositol transfer protein alpha	Homo sapiens	103-113
14729069-4	2003	GroPCho inhibited the ability of PITP-alpha to transfer PtdIns or PtdCho between liposomes.	Phosphatidylcholines	66-72	phosphatidylinositol transfer protein alpha	Homo sapiens	33-43
14729070-3	2003	When platelets were preesterified with either 25 microM 9t, 11t-CLA or 9c, 11c-CLA, CLA incorporation in total platelet lipids increased from 0.24% to 0.31% and 0.38%, and most of this increase was found to be in the phosphatidyl choline and phosphatidyl ethanolamine subclasses.	Phosphatidylcholines	217-237	olfactory receptor family 1 subfamily L member 1	Homo sapiens	68-73
12922983-2	2003	Parathyroid hormone-related protein (PTHrP) 1-34 could have a regulatory role in this process because it stimulates phosphatidylcholine secretion and inhibits type II cell growth.	Phosphatidylcholines	116-135	parathyroid hormone like hormone	Homo sapiens	0-35
12922983-2	2003	Parathyroid hormone-related protein (PTHrP) 1-34 could have a regulatory role in this process because it stimulates phosphatidylcholine secretion and inhibits type II cell growth.	Phosphatidylcholines	116-135	parathyroid hormone like hormone	Homo sapiens	37-42
12922983-6	2003	Reversing the decline in PTHrP 1-34 or PTHrP 67-86 with one intratracheal dose and four daily subcutaneous doses of PTHrP 1-34 or PTHrP 67-86 stimulated bronchoalveolar lavage disaturated phosphatidylcholine (DSPC) levels.	Phosphatidylcholines	188-207	parathyroid hormone like hormone	Homo sapiens	25-30
14514684-7	2003	Moreover, we demonstrate for the first time that phosphatidylcholine and phosphatidylethanolamine, which are the main components of the mitochondrial outer membrane, are potent activators of both enzymatic activities of CoA synthase in vitro.	Phosphatidylcholines	49-68	Coenzyme A synthase	Homo sapiens	220-232
14636062-0	2003	Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.	Phosphatidylcholines	134-153	lecithin-cholesterol acyltransferase	Homo sapiens	92-129
14636062-1	2003	We previously described a point mutation in human LCAT (E to A at residue 149; hE149A) that demonstrated greater activity with phosphatidylcholine (PC) substrate containing 20:4 in the sn-2 position compared with the wild-type enzyme [hLCAT; Wang et al.	Phosphatidylcholines	127-146	lecithin-cholesterol acyltransferase	Homo sapiens	50-54
14636062-1	2003	We previously described a point mutation in human LCAT (E to A at residue 149; hE149A) that demonstrated greater activity with phosphatidylcholine (PC) substrate containing 20:4 in the sn-2 position compared with the wild-type enzyme [hLCAT; Wang et al.	Phosphatidylcholines	148-150	lecithin-cholesterol acyltransferase	Homo sapiens	50-54
14636062-7	2003	In the second experiment, we found that hE149A compared with hLCAT demonstrated higher activity with PC species containing 20-carbon, but not 18-carbon, sn-2 fatty acyl chains.	Phosphatidylcholines	101-103	lecithin-cholesterol acyltransferase	Homo sapiens	61-66
14636062-9	2003	Substitution of different amino acids in the 149 position of hLCAT showed that activation of the enzyme with sn-2 20:4 containing PC substrate was only observed when the negative charge at residue 149 was removed.	Phosphatidylcholines	130-132	lecithin-cholesterol acyltransferase	Homo sapiens	61-66
14597574-0	2003	Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis.	Phosphatidylcholines	8-27	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-4
14597574-3	2003	Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine.	Phosphatidylcholines	212-231	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	80-120
14597574-3	2003	Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine.	Phosphatidylcholines	212-231	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	122-125
14646617-4	2003	Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines.	Phosphatidylcholines	27-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	311-314
14608048-8	2003	These findings indicate that PEMT activity functions beyond its recognized role as a compensatory pathway for PC biosynthesis and that, in contrast, PEMT activity is involved in many physiologic processes including the flux of lipid between liver and plasma and the delivery of essential fatty acids to blood and peripheral tissues via the liver-derived lipoproteins.	Phosphatidylcholines	110-112	phosphatidylethanolamine N-methyltransferase	Mus musculus	29-33
14583784-5	2003	In addition, both U-73122, which inhibits agonist-induced phospholipase C (PLC) activation and D609, a specific inhibitor of phosphatidylcholine-specific PLC also inhibited PIF-induced proteasome activity.	Phosphatidylcholines	125-144	Pif	Mus musculus	173-176
14580712-0	2003	Linkage identity is a major factor in determining the effect of PEG-ylated surfactants on permeability of phosphatidylcholine liposomes.	Phosphatidylcholines	106-125	progestagen associated endometrial protein	Homo sapiens	64-67
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	114-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
14596606-10	2003	Alpha-synuclein exhibits a selectivity of interaction with different phospholipid spin labels when bound to phosphatidylglycerol membranes in the following order: stearic acid &gt; cardiolipin &gt; phosphatidylcholine &gt; phosphatidylglycerol approximately phosphatidylethanolamine &gt; phosphatidic acid approximately phosphatidylserine &gt; N-acyl phosphatidylethanolamine &gt; diglyceride.	Phosphatidylcholines	198-217	synuclein alpha	Homo sapiens	0-15
12928431-3	2003	We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	24-26	nerve growth factor	Rattus norvegicus	35-54
12928431-3	2003	We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	24-26	nerve growth factor	Rattus norvegicus	56-59
12928431-3	2003	We hypothesized that in PC12 cells nerve growth factor (NGF) would up-regulate the activity and expression of the rate-limiting enzyme in PC biosynthesis, CTP:phosphocholine cytidylyltransferase (CT).	Phosphatidylcholines	24-26	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	155-194
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	114-133	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
14664823-1	2003	Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid.	Phosphatidylcholines	39-58	phospholipase A2, group IB, pancreas	Mus musculus	0-18
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	135-137	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	135-137	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	188-190	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
14608048-1	2003	Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis.	Phosphatidylcholines	188-190	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
14608048-2	2003	Mice with a homozygous disruption of the PEMT gene are dependent on the 1,2-diacylglycerol cholinephosphotransferase (CDP-choline) pathway for the synthesis of PC and develop severe liver steatosis when fed a diet deficient in choline.	Phosphatidylcholines	160-162	phosphatidylethanolamine N-methyltransferase	Mus musculus	41-45
14608048-2	2003	Mice with a homozygous disruption of the PEMT gene are dependent on the 1,2-diacylglycerol cholinephosphotransferase (CDP-choline) pathway for the synthesis of PC and develop severe liver steatosis when fed a diet deficient in choline.	Phosphatidylcholines	160-162	cut-like homeobox 1	Mus musculus	118-121
14664823-1	2003	Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid.	Phosphatidylcholines	39-58	phospholipase A2, group IB, pancreas	Mus musculus	20-26
12917409-4	2003	ABCA7 expression increased cellular phosphatidylcholine and sphingomyelin efflux to apoA-I in a manner similar to ABCA1 but had no effect on cholesterol efflux.	Phosphatidylcholines	36-55	ATP binding cassette subfamily A member 7	Homo sapiens	0-5
12913002-7	2003	The appearance of this surface suggests a putative binding region for membrane-derived SP-A ligands such as phosphatidylcholine and lipid A, the endotoxic lipid component of bacterial lipopolysaccharide that mediates the potentially lethal effects of Gram-negative bacterial infection.	Phosphatidylcholines	108-127	surfactant protein A1	Homo sapiens	87-91
12915713-10	2003	The inhibition of diacylglycerol lipase partially blocked and the selective inhibition of Src kinases and phosphatidylcholine-specific phospholipase C (PC-PLC) completely blocked the inhibitory effects of the noncoplanar PCB on GJIC, indicating that PC-PLC or sphingomyelinase and Src might be upstream regulators of noncoplanar PCB-induced inhibition of GJIC.	Phosphatidylcholines	106-125	pyruvate carboxylase	Rattus norvegicus	221-224
12917409-4	2003	ABCA7 expression increased cellular phosphatidylcholine and sphingomyelin efflux to apoA-I in a manner similar to ABCA1 but had no effect on cholesterol efflux.	Phosphatidylcholines	36-55	apolipoprotein A1	Homo sapiens	84-90
14530366-3	2003	We investigated the potential role of phosphoinositide 3-kinase (PI3K) in the activation of gIV-PLA(2) and the hydrolysis of membrane phosphatidylcholine in fMLP-stimulated human blood eosinophils.	Phosphatidylcholines	134-153	formyl peptide receptor 1	Homo sapiens	157-161
12912985-1	2003	Phosphatidylserine (PtdSer) in mammalian cells is synthesized through the action of PtdSer synthase (PSS) 1 and 2, which catalyze the conversion of phosphatidylcholine and phosphatidylethanolamine, respectively, to PtdSer.	Phosphatidylcholines	148-167	phosphatidylserine synthase 1	Homo sapiens	84-113
12857760-0	2003	Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	41-60	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	104-143
14530343-0	2003	Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6.	Phosphatidylcholines	0-19	signal transducer and activator of transcription 6	Homo sapiens	89-94
14530343-5	2003	We discovered that inhibitors of phosphatidylcholine-specific phospholipase C (PC-PLC), but not other lipases, blocked the activation of STAT6 by IL-4.	Phosphatidylcholines	33-52	signal transducer and activator of transcription 6	Homo sapiens	137-142
14530343-5	2003	We discovered that inhibitors of phosphatidylcholine-specific phospholipase C (PC-PLC), but not other lipases, blocked the activation of STAT6 by IL-4.	Phosphatidylcholines	33-52	interleukin 4	Homo sapiens	146-150
12796497-5	2003	As low a concentration as 10 nm exogenous hVPLA2 was able to elicit the significant release of AA and LTC4 from unstimulated eosinophils, which depended on its ability to act on phosphatidylcholine membranes.	Phosphatidylcholines	178-197	phospholipase A2 group V	Homo sapiens	42-48
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	0-19	cut-like homeobox 1	Mus musculus	53-56
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	81-125
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	127-131
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	21-23	cut-like homeobox 1	Mus musculus	53-56
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	81-125
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	127-131
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	196-198	phosphatidylethanolamine N-methyltransferase	Mus musculus	81-125
12837848-1	2003	Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.	Phosphatidylcholines	196-198	phosphatidylethanolamine N-methyltransferase	Mus musculus	127-131
12837848-16	2003	Secretion of PEMT-derived PC into lipoproteins was examined in vivo by injection of mice with [methyl-3H]methionine in the presence of Triton WR1339.	Phosphatidylcholines	26-28	phosphatidylethanolamine N-methyltransferase	Mus musculus	13-17
12837848-18	2003	Secretion of PEMT-derived PC into bile was enhanced in mice fed a HF/HC diet.	Phosphatidylcholines	26-28	phosphatidylethanolamine N-methyltransferase	Mus musculus	13-17
12837848-19	2003	These results demonstrate that the synthesis and targeting of PC produced by the PEMT pathway in the livers of mice differs in a gender- and diet-specific manner.	Phosphatidylcholines	62-64	phosphatidylethanolamine N-methyltransferase	Mus musculus	81-85
14536058-3	2003	Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels.	Phosphatidylcholines	100-102	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	65-69
14536058-3	2003	Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels.	Phosphatidylcholines	171-173	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	65-69
14536058-7	2003	A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic.	Phosphatidylcholines	23-25	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	105-110
14536058-7	2003	A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic.	Phosphatidylcholines	23-25	Epidermal growth factor receptor	Drosophila melanogaster	116-120
14536058-7	2003	A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic.	Phosphatidylcholines	23-25	Notch	Drosophila melanogaster	122-127
12842877-5	2003	This approach identified mutations in a single gene, YNL323W/LEM3, that conferred resistance to alkylphosphocholine drugs and inhibited internalization of NBD-labeled phosphatidylcholine.	Phosphatidylcholines	167-186	Lem3p	Saccharomyces cerevisiae S288C	61-65
12842877-11	2003	These data demonstrate a requirement for Lem3p expression for normal phosphatidylcholine and alkylphosphocholine drug transport across the plasma membrane of yeast.	Phosphatidylcholines	69-88	Lem3p	Saccharomyces cerevisiae S288C	41-46
12893687-0	2003	Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP, and CETP in plasma and peripheral lymph in humans.	Phosphatidylcholines	42-61	lecithin-cholesterol acyltransferase	Homo sapiens	71-75
12842883-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions.	Phosphatidylcholines	147-166	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
12842883-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions.	Phosphatidylcholines	147-166	phosphatidylethanolamine N-methyltransferase	Homo sapiens	46-50
12893687-1	2003	OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans.	Phosphatidylcholines	72-91	apolipoprotein A1	Homo sapiens	53-71
12893687-1	2003	OBJECTIVE: We have previously shown that intravenous apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs increase plasma pre-beta HDL concentration and stimulate reverse cholesterol transport (RCT) in humans.	Phosphatidylcholines	72-91	apolipoprotein A1	Homo sapiens	93-102
12810817-9	2003	Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile.	Phosphatidylcholines	81-83	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	142-146
12810817-9	2003	Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile.	Phosphatidylcholines	81-83	scavenger receptor class B, member 1	Mus musculus	151-156
14517341-2	2003	PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis.	Phosphatidylcholines	39-58	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
14517341-2	2003	PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis.	Phosphatidylcholines	60-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
12922169-13	2003	We demonstrate, using fluorescence resonance energy transfer, that at low concentrations, NAP-22 labeled with Texas Red binds equally well to liposomes of phosphatidylcholine either with or without the addition of 40 mol% cholesterol.	Phosphatidylcholines	155-174	brain abundant membrane attached signal protein 1	Homo sapiens	90-96
12813037-4	2003	Efflux of low density lipoprotein-derived, non-lipoprotein, plasma membrane, and newly synthesized pools of cell cholesterol by apoA-I was diminished in NPC1-/- cells, as was efflux of phosphatidylcholine and sphingomyelin.	Phosphatidylcholines	185-204	NPC intracellular cholesterol transporter 1	Homo sapiens	153-157
12799368-10	2003	Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine.	Phosphatidylcholines	235-254	histone demethylase GIS1	Saccharomyces cerevisiae S288C	41-45
12799368-10	2003	Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine.	Phosphatidylcholines	235-254	histone demethylase GIS1	Saccharomyces cerevisiae S288C	71-76
12869188-6	2003	In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover.	Phosphatidylcholines	143-162	Csr1p	Saccharomyces cerevisiae S288C	82-87
12865160-10	2003	Moxonidine-induced induction of MKP-2 was time- and dose-dependent and could be blocked by the I(1)-antagonist efaroxan or by D609, an inhibitor of phosphatidylcholine-selective phospholipase C known to block downstream signaling events coupled to I(1)-receptors.	Phosphatidylcholines	148-167	dual specificity phosphatase 4	Rattus norvegicus	32-37
12899624-0	2003	Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined.	Phosphatidylcholines	157-176	phospholipase C beta 1	Homo sapiens	118-124
12899624-0	2003	Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C. The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined.	Phosphatidylcholines	178-180	phospholipase C beta 1	Homo sapiens	118-124
12869188-6	2003	In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover.	Phosphatidylcholines	143-162	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	92-97
12869188-6	2003	In contrast to Sec14p, which inhibits phospholipase D1 (Pld1p), overproduction of Sfh2p and Sfh4p resulted in the activation of Pld1p-mediated phosphatidylcholine turnover.	Phosphatidylcholines	143-162	phospholipase D	Saccharomyces cerevisiae S288C	128-133
12869188-7	2003	Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo.	Phosphatidylcholines	120-139	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	15-21
12869188-7	2003	Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo.	Phosphatidylcholines	120-139	Csr1p	Saccharomyces cerevisiae S288C	45-50
12869188-7	2003	Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo.	Phosphatidylcholines	120-139	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	55-60
12869188-7	2003	Interestingly, Sec14p and the two homologues Sfh2p and Sfh4p downregulate phospholipase B1 (Plb1p)-mediated turnover of phosphatidylcholine in vivo.	Phosphatidylcholines	120-139	lysophospholipase	Saccharomyces cerevisiae S288C	92-97
12859204-5	2003	Compared to wild-type littermates, Abca1(-/-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin (SPH) (49-fold), and phosphatidylethanolamine (PE) (18-fold) showed even higher increases.	Phosphatidylcholines	75-77	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	35-40
12837922-9	2003	Blockade of phosphatidylcholine and phosphatidyl-ethanolamine transfer by a 60 min, 56 degrees C heating step or with anti-PLTP antibody revealed that PLTP accounts for almost 80% of the phospholipid transfer activity present in seminal plasma.	Phosphatidylcholines	12-31	phospholipid transfer protein	Homo sapiens	151-155
12818350-9	2003	Messenger RNA export rate in PLA(2) (10(-3) unit/mL)- treated nuclear membrane was positively correlated with level of PC incorporation, both using ATP and GTP as substrates.	Phosphatidylcholines	119-121	phospholipase A2 group IB	Rattus norvegicus	29-35
12842190-1	2003	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction.	Phosphatidylcholines	76-95	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
12730219-9	2003	In contrast to oleic acid and sphingosine that exhibited inhibitory effects, phosphatidylcholine, phosphatidylserine, and phosphatidic acid stimulated MGAT2 activities.	Phosphatidylcholines	77-96	mannoside acetylglucosaminyltransferase 2	Mus musculus	151-156
12842190-1	2003	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction.	Phosphatidylcholines	76-95	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
12842190-1	2003	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
12842190-1	2003	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PtdCho) biosynthesis, and in mammals, there are two distinct genes that encode enzymes that catalyze this reaction.	Phosphatidylcholines	97-103	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
12842190-7	2003	These data suggest unique roles for the CCT protein isoforms in the differential regulation of PtdCho biosynthesis in specific tissues.	Phosphatidylcholines	95-101	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	40-43
12865412-3	2003	KGF stimulated acetate incorporation into phosphatidylcholine, disaturated phosphatidylcholine, and phosphatidylglycerol more than 5% rat serum alone.	Phosphatidylcholines	42-61	fibroblast growth factor 7	Homo sapiens	0-3
12934648-7	2003	This enzyme hydrolyzed PAF and oxidatively modified phosphatidylcholine.	Phosphatidylcholines	52-71	PCNA clamp associated factor	Homo sapiens	23-26
12940517-9	2003	In order to get more reliable results, we recommend that clinicians and researchers use NBD-phosphatidylcholines as PLA2 substrates in biological samples and start with an analytical separation of reaction products followed by image analysis of the fluorescent spots.	Phosphatidylcholines	92-112	phospholipase A2 group IB	Homo sapiens	116-120
12732938-2	2003	We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model.	Phosphatidylcholines	115-134	interleukin 6	Homo sapiens	57-61
12732938-2	2003	We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model.	Phosphatidylcholines	115-134	phospholipase A2 group X	Homo sapiens	90-97
12732938-8	2003	Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p&lt;0.05).	Phosphatidylcholines	208-227	interleukin 6	Homo sapiens	62-66
12732938-8	2003	Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p&lt;0.05).	Phosphatidylcholines	229-231	interleukin 6	Homo sapiens	62-66
12809502-2	2003	Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers.	Phosphatidylcholines	198-217	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-75
12809502-2	2003	Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers.	Phosphatidylcholines	219-221	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-75
12771001-5	2003	Dose-response curves were repeated after systemic infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) disks.	Phosphatidylcholines	81-100	apolipoprotein A1	Homo sapiens	102-111
12872987-0	2003	Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide.	Phosphatidylcholines	45-64	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-30
12872987-3	2003	LPS enhances expression of COX-2 mRNA and protein by activating sequentially phosphatidylcholine-specific phospholipase C (PC-PLC), protein kinase C (PKC) and phosphatidylcholine-specific phospholipase D (PC-PLD).	Phosphatidylcholines	77-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	27-32
12668679-0	2003	A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice.	Phosphatidylcholines	80-99	phosphatidylethanolamine N-methyltransferase	Mus musculus	27-71
12668679-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver.	Phosphatidylcholines	104-123	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
12670959-4	2003	Measurements of cross-relaxation rates in two-dimensional nuclear Overhauser enhancement spectroscopy NMR experiments show that the five Phe rings of MARCKS-(151-175) penetrate into the acyl chain region of phosphatidylcholine bilayers containing phosphatidylglycerol or PI(4,5)P2.	Phosphatidylcholines	207-226	myristoylated alanine rich protein kinase C substrate	Homo sapiens	150-156
12668679-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver.	Phosphatidylcholines	104-123	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
12668679-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver.	Phosphatidylcholines	125-127	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
12668679-1	2003	Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver.	Phosphatidylcholines	125-127	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
12668679-6	2003	Moreover, female and, to a lesser extent, male Pemt-/- mice showed a striking 40% decrease in plasma PC and cholesterol in high density lipoproteins.	Phosphatidylcholines	101-103	phosphatidylethanolamine N-methyltransferase	Mus musculus	47-51
12771334-2	2003	In this study, it inhibited human and porcine pancreatic lipase activity in substrate emulsions containing bile salts and phosphatidylcholine, in the concentration range of 10-1000 mg/L.	Phosphatidylcholines	122-141	lipase G, endothelial type	Rattus norvegicus	57-63
12787934-8	2003	Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively.	Phosphatidylcholines	301-320	NK2 homeobox 1	Homo sapiens	77-81
12787934-8	2003	Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively.	Phosphatidylcholines	301-320	NK2 homeobox 1	Homo sapiens	155-159
12787934-8	2003	Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively.	Phosphatidylcholines	322-324	NK2 homeobox 1	Homo sapiens	77-81
12787934-8	2003	Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively.	Phosphatidylcholines	322-324	NK2 homeobox 1	Homo sapiens	155-159
12962277-6	2003	Addition of a mol fraction of phosphatidylserine of 0.05 to membranes of phosphatidylcholine and cholesterol enhances the membrane binding of NAP-22.	Phosphatidylcholines	73-92	brain abundant membrane attached signal protein 1	Homo sapiens	142-148
12706232-1	2003	Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC).	Phosphatidylcholines	113-132	cut-like homeobox 1	Rattus norvegicus	23-26
12745074-6	2003	Furthermore, indolicidin caused significant morphological changes when tested for the membrane disrupting activity using liposomes (phosphatidylcholine/cholesterol; 10:1, w/w).	Phosphatidylcholines	132-151	cathelicidin-4	Bos taurus	13-24
12764097-5	2003	Exposure of cortical neurons to neurotoxic concentrations of NMDA increased extracellular choline and activated hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 but did not induce significant degradation of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, or phosphatidylserine.	Phosphatidylcholines	126-145	phospholipase A2 group IB	Homo sapiens	174-190
12706232-1	2003	Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC).	Phosphatidylcholines	134-136	cut-like homeobox 1	Rattus norvegicus	23-26
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Phosphatidylcholines	229-248	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-45
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Phosphatidylcholines	229-248	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	47-55
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Phosphatidylcholines	229-248	cut-like homeobox 1	Rattus norvegicus	185-188
12534371-1	2003	We investigated the kinetic behaviour and substrate specificity of PTEN (phosphatase and tensin homologue deleted on chromosome 10) using unilamellar vesicles containing substrate lipids in a background of phosphatidylcholine.	Phosphatidylcholines	206-225	phosphatase and tensin homolog	Homo sapiens	67-71
12743757-6	2003	Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors.	Phosphatidylcholines	119-138	diacylglycerol O-acyltransferase	Saccharomyces cerevisiae S288C	76-81
12743757-6	2003	Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors.	Phosphatidylcholines	119-138	phospholipid:diacylglycerol acyltransferase	Saccharomyces cerevisiae S288C	86-91
12761300-6	2003	These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway.	Phosphatidylcholines	128-147	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	28-33
12695484-3	2003	We show that Anx4 exhibited binding to liposomes (phosphatidylcholine:phosphatidylserine, 1:1) in the presence of Ca2+ and binding was reversible with EDTA.	Phosphatidylcholines	50-69	annexin A4	Homo sapiens	13-17
12659848-3	2003	In this study, using fluorescence resonance energy transfer, we found that after A beta binds to raft-like membranes composed of monosialoganglioside GM1/cholesterol/sphingomyelin (1/1/1), the protein can translocate to the phosphatidylcholine membranes to which soluble A beta does not bind.	Phosphatidylcholines	224-243	amyloid beta precursor protein	Homo sapiens	81-87
12761300-6	2003	These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway.	Phosphatidylcholines	128-147	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	98-102
12871410-6	2003	In contrast, addition of phosphatidylcholine/phosphatidylserine vesicles corrected prolonged clotting times caused by either anti-beta2GPI or antiprothrombin antibodies with LAC activity.	Phosphatidylcholines	25-44	apolipoprotein H	Homo sapiens	130-138
12691414-1	2003	OBJECT: In previous studies at their laboratory the authors showed that cytidinediphosphocholine (CDP-choline), an intermediate of phosphatidylcholine synthesis, decreases edema formation and blood-brain barrier disruption following traumatic brain injury (TBI).	Phosphatidylcholines	131-150	cut-like homeobox 1	Rattus norvegicus	98-101
12633683-8	2003	The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM.	Phosphatidylcholines	105-107	lipoprotein lipase	Homo sapiens	26-44
12633683-8	2003	The stimulatory effect of lipoprotein lipase (LPL) on emulsion uptake was decreased by replacing surface PC with SM.	Phosphatidylcholines	105-107	lipoprotein lipase	Homo sapiens	46-49
12632206-1	2003	We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes.	Phosphatidylcholines	242-244	OXA1L mitochondrial inner membrane protein	Homo sapiens	99-104
12604528-2	2003	More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA(2) at 10 micro M Ca(2+) was attenuated by these peptides while augmented product formation was observed in the presence of 5 mM Ca(2+).	Phosphatidylcholines	33-52	phospholipase A2 group X	Homo sapiens	81-88
12466019-7	2003	In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups.	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Mus musculus	108-112
12466019-7	2003	In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups.	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Mus musculus	144-148
12466019-7	2003	In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt (-/-) choline deficient and in Pemt (-/-) choline control groups but returned to normal in Pemt (-/-) choline supplemented groups.	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Mus musculus	144-148
12603829-3	2003	Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS).	Phosphatidylcholines	74-93	palmitoyl-protein thioesterase 1	Homo sapiens	32-36
12562848-5	2003	PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho.	Phosphatidylcholines	96-102	pleckstrin and Sec7 domain containing	Homo sapiens	19-24
12562848-5	2003	PtdEtn produced by Psd1p and Psd2p can be transported to the ER, where it is methylated to form PtdCho.	Phosphatidylcholines	96-102	pleckstrin and Sec7 domain containing 2	Homo sapiens	29-34
12603829-3	2003	Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS).	Phosphatidylcholines	95-97	palmitoyl-protein thioesterase 1	Homo sapiens	32-36
12612149-5	2003	The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio.	Phosphatidylcholines	292-294	fatty acid desaturase 2	Rattus norvegicus	37-61
12612149-5	2003	The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio.	Phosphatidylcholines	292-294	fatty acid desaturase 2	Rattus norvegicus	49-60
12482759-3	2003	A potential source for homocysteine is methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase in the liver.	Phosphatidylcholines	92-111	phosphatidylethanolamine N-methyltransferase	Mus musculus	115-159
12631737-4	2003	Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected.	Phosphatidylcholines	133-152	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	8-13
12631737-4	2003	Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected.	Phosphatidylcholines	133-152	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	18-23
12749692-1	2003	Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory.	Phosphatidylcholines	97-116	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	22-27
12547783-4	2003	For phosphatidylcholine spin-labeled at different positions down the sn-2 chain, the amplitude of the deuterium signal decreases toward the center of the membrane, and is reduced to zero from the C-12 atom position onward.	Phosphatidylcholines	4-23	solute carrier family 38 member 5	Homo sapiens	69-73
12546662-1	2003	Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
12546662-1	2003	Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
12540796-5	2003	Cationic liposomes composed of DDAB and equimolar of a neutral lipid, egg yolk phosphatidylcholine (EPC), induced the strongest antigen-specific Th1 type immune responses among the cationic liposome investigated, whereas the liposomes composed of 2 cationic lipids, DDAB and DOEPC, induced an antigen-specific Th2 type immune response.	Phosphatidylcholines	79-98	negative elongation factor complex member C/D	Homo sapiens	145-148
12749692-1	2003	Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory.	Phosphatidylcholines	97-116	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	29-34
12749692-1	2003	Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory.	Phosphatidylcholines	97-116	SEC14 like lipid binding 4	Homo sapiens	39-44
12749692-1	2003	Three human proteins (hTAP1, hTAP2 and hTAP3) that are related to the yeast phosphatidylinositol/phosphatidylcholine transfer protein SEC14p were recently cloned in our laboratory.	Phosphatidylcholines	97-116	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	134-140
12931022-1	2003	OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate.	Phosphatidylcholines	62-81	phosphatidylethanolamine N-methyltransferase	Homo sapiens	96-140
13129817-0	2003	Apoptosis mediated by phosphatidylcholine-specific phospholipase C is associated with cAMP, p53 level, and cell-cycle distribution in vascular endothelial cells.	Phosphatidylcholines	22-41	tumor protein p53	Homo sapiens	92-95
12598036-5	2003	This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains.	Phosphatidylcholines	88-107	brain abundant membrane attached signal protein 1	Homo sapiens	143-149
12598036-5	2003	This finding, along with effects of the protein on the phase transitions of mixtures of phosphatidylcholine (PC) and cholesterol indicate that NAP-22 facilitates the formation of cholesterol-rich domains.	Phosphatidylcholines	109-111	brain abundant membrane attached signal protein 1	Homo sapiens	143-149
12519189-4	2003	Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3.	Phosphatidylcholines	61-80	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	95-99
12519189-4	2003	Finally, valproate, but not lithium, increases expression of phosphatidylcholine pathway genes CHO1 and OPI3.	Phosphatidylcholines	61-80	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	104-108
12931022-1	2003	OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate.	Phosphatidylcholines	62-81	phosphatidylethanolamine N-methyltransferase	Homo sapiens	142-146
12361952-2	2002	Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine.	Phosphatidylcholines	140-159	phosphatidylserine synthase 1	Mus musculus	0-4
12899657-2	2003	Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC).	Phosphatidylcholines	19-38	insulin	Homo sapiens	0-7
12899657-2	2003	Insulin stimulated phosphatidylcholine (PC) and phosphatidyl-inositol (PI) degradation through the activation of specific phospholipases C (PLC).	Phosphatidylcholines	40-42	insulin	Homo sapiens	0-7
12359733-7	2002	A dramatic correlation exists between the ability of the sPLA(2)s to hydrolyze phosphatidylcholine-rich vesicles efficiently in vitro and the ability to release arachidonic acid when added exogenously to mammalian cells; the group V and X sPLA(2)s are uniquely efficient in this regard.	Phosphatidylcholines	79-98	phospholipase A2 group IID	Homo sapiens	57-65
12244093-2	2002	The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin.	Phosphatidylcholines	115-134	glucosidase II alpha subunit	Homo sapiens	105-110
12244093-2	2002	The much higher enzymatic activity of human group X sPLA(2) (hGX) compared with human group IIA sPLA(2) (hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol and sphingomyelin.	Phosphatidylcholines	136-138	glucosidase II alpha subunit	Homo sapiens	105-110
12443983-1	2002	Citicoline, or CDP-choline, is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine that may act as a neuroprotector in several models of neurodegeneration.	Phosphatidylcholines	91-110	cut like homeobox 1	Homo sapiens	15-18
12361952-2	2002	Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine.	Phosphatidylcholines	140-159	phosphatidylserine synthase 2	Mus musculus	9-13
12361952-2	2002	Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine.	Phosphatidylcholines	140-159	phosphatidylserine synthase 1	Mus musculus	129-133
12228236-3	2002	Similarly, when apolipoprotein A-I removed cellular cholesterol, phosphatidylcholine, and sphingomyelin to generate high density lipoprotein, cholesterol synthesis from acetate subsequently increased, and sphingomyelin synthesis from acetate and serine also increased.	Phosphatidylcholines	65-84	apolipoprotein A-I	Mus musculus	16-34
12472619-4	2002	As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2).	Phosphatidylcholines	41-61	phospholipase A2 group IB	Homo sapiens	98-114
12472619-4	2002	As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2).	Phosphatidylcholines	41-61	phospholipase A2 group IB	Homo sapiens	116-120
12472619-4	2002	As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2).	Phosphatidylcholines	63-65	phospholipase A2 group IB	Homo sapiens	98-114
12472619-4	2002	As a model system, liposomes composed of phosphatidylcholines (PC) from egg yolk were digested by phospholipase A2 (PLA2).	Phosphatidylcholines	63-65	phospholipase A2 group IB	Homo sapiens	116-120
12200438-2	2002	In this study, we have used both nutritional deprivation as well as a conditional temperature sensitive allele of PCT1 (CTP:phosphocholine cytidylyltransferase) coupled with an inactivated phosphatidylethanolamine methylation pathway to determine how cells respond to inactivation of phosphatidylcholine synthesis.	Phosphatidylcholines	284-303	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	114-118
12200438-3	2002	Metabolic studies determined that phosphatidylcholine biosynthesis decreased to negligible levels within 1 h upon shift to the nonpermissive temperature for the temperature-sensitive PCT1 allele.	Phosphatidylcholines	34-53	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	183-187
12200438-8	2002	Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity.	Phosphatidylcholines	67-86	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	0-5
12200438-8	2002	Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity.	Phosphatidylcholines	67-86	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	31-37
12200438-8	2002	Pct1p activity is regulated by Sec14p, a cytoplasm/Golgi localized phosphatidylcholine/phosphatidylinositol binding protein that regulates Golgi-derived vesicle transport partially through its ligand-dependent regulation of PCT1 derived enzyme activity.	Phosphatidylcholines	67-86	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	224-228
12193594-1	2002	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	108-127	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
12421918-7	2002	We found a similar frequency of phosphatidylcholine-specific CD5(+) B-1 cells in the two strains of mice.	Phosphatidylcholines	32-51	CD5 antigen	Mus musculus	61-64
12408975-3	2002	The oxidation products of 1- and/or 2-oleoyl phosphatidylcholine (PC) or phosphatidylethanolamine were the most potent compounds, while those of arachidonyl PC possessed only a weak inhibitory effect on the TFPI activity.	Phosphatidylcholines	66-68	tissue factor pathway inhibitor	Homo sapiens	207-211
12414547-1	2002	AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine.	Phosphatidylcholines	85-104	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	6-50
12414547-1	2002	AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine.	Phosphatidylcholines	85-104	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	52-56
12180909-1	2002	The apoptotic protein Bax, in oligomeric form, is effective in promoting both leakage and lipid mixing in liposomes composed of cardiolipin and phosphatidylethanolamine and/or phosphatidylcholine, upon the addition of calcium.	Phosphatidylcholines	176-195	BCL2 associated X, apoptosis regulator	Homo sapiens	22-25
12223447-0	2002	Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide.	Phosphatidylcholines	0-19	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	108-147
12193594-1	2002	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	108-127	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
12193594-1	2002	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	129-131	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
12193594-1	2002	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC).	Phosphatidylcholines	129-131	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
12512933-2	2002	Addition of the major proteolipid (PLP) to phosphatidylcholine-cholesterol vesicles caused their clustering as determined by increase in O.D.	Phosphatidylcholines	43-62	proteolipid protein 1	Homo sapiens	35-38
12429836-1	2002	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
12429836-1	2002	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
12442901-1	2002	We investigated the possible involvement of phosphatidylcholine-specific phospholipase C (PC-PLC) in the thyroid-stimulating hormone (TSH)-induced protein kinase C (PKC)/phospholipase D (PLD) activation in FRTL-5 thyroid cells.	Phosphatidylcholines	44-63	protein kinase C, alpha	Rattus norvegicus	165-168
12271462-2	2002	PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho.	Phosphatidylcholines	0-6	phospholipase A2 group IB	Homo sapiens	21-39
12183451-4	2002	ALP inhibited PC synthesis at the CTP:phosphocholine cytidylyltransferase (CT) step in S49 cells, but not in S49(AR) cells.	Phosphatidylcholines	14-16	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	34-73
12271462-2	2002	PtdCho hydrolysis by phospholipase A(2) (PLA(2)) after cerebral ischemia and reperfusion yields arachidonic acid (ArAc) and lyso-PtdCho.	Phosphatidylcholines	0-6	phospholipase A2 group IB	Homo sapiens	41-47
12133835-6	2002	Disruption of the ROS3 gene resulted in a marked decrease in the internalization of fluorescence-labeled analogs of PE and phosphatidylcholine, whereas the uptake of fluorescence-labeled phosphatidylserine and endocytic markers was not affected.	Phosphatidylcholines	123-142	Lem3p	Saccharomyces cerevisiae S288C	18-22
12167660-4	2002	To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids.	Phosphatidylcholines	76-95	Gat1p	Saccharomyces cerevisiae S288C	140-144
12167660-4	2002	To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids.	Phosphatidylcholines	76-95	Gat2p	Saccharomyces cerevisiae S288C	149-153
12167660-4	2002	To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids.	Phosphatidylcholines	76-95	Gat2p	Saccharomyces cerevisiae S288C	238-242
12167660-6	2002	Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation.	Phosphatidylcholines	280-299	Gat1p	Saccharomyces cerevisiae S288C	21-25
12167660-6	2002	Our data showed that gat1 and gat2 yeast were resistant and sensitive to lysoplatelet activating factor, platelet activating factor, and the anti-tumor lipid edelfosine, respectively, indicating that their sensitivity to these compounds was not because of differences in rates of phosphatidylcholine deacylation.	Phosphatidylcholines	280-299	Gat2p	Saccharomyces cerevisiae S288C	30-34
12167660-9	2002	Our results are consistent with a model whereby phosphatidic acid generated from phosphatidylcholine hydrolysis by Spo14p regulates susceptibility to choline-containing lysolipid analogs and drugs.	Phosphatidylcholines	81-100	phospholipase D	Saccharomyces cerevisiae S288C	115-121
12471472-2	2002	We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	60-79	phospholipase A2 group IB	Homo sapiens	26-32
12359261-3	2002	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	81-83	choline phosphotransferase 1	Homo sapiens	0-25
12359261-3	2002	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	81-83	choline phosphotransferase 1	Homo sapiens	27-30
12359261-3	2002	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	139-141	choline phosphotransferase 1	Homo sapiens	0-25
12359261-3	2002	Cholinephosphotransferase (CPT), the terminal enzyme in the de novo synthesis of PC, has an important role in regulating the acyl group of PC in mammalian cells.	Phosphatidylcholines	139-141	choline phosphotransferase 1	Homo sapiens	27-30
12323087-7	2002	However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations.	Phosphatidylcholines	236-238	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	13-16
12355253-5	2002	This is consistent with the preferential interaction between PDC-109 and phosphatidylcholine.	Phosphatidylcholines	73-92	seminal plasma protein PDC-109	Bos taurus	61-68
12355253-6	2002	It is concluded that a stronger association and interaction of PDC-109 with phosphatidylcholine leads to an enhanced fraction of immobilized cholesterol analogues, but not to a phospholipid-dependent specific interaction between the protein and cholesterol.	Phosphatidylcholines	76-95	seminal plasma protein PDC-109	Bos taurus	63-70
12355253-7	2002	Moreover, the interaction of PDC-109 with various spin-labelled analogues of phosphatidylcholine (lysoPC, diacylPC) was investigated.	Phosphatidylcholines	77-96	seminal plasma protein PDC-109	Bos taurus	29-36
12353276-5	2002	The molar ratio of PTC to PC increased fourfold in differentiated 3T3 F442A cells compared to undifferentiated cells, suggesting a substantial increase in CTP:phosphocholine cytidylyltransferase activity with differentiation.	Phosphatidylcholines	19-22	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	155-194
12323087-7	2002	However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations.	Phosphatidylcholines	91-110	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	13-16
12323087-7	2002	However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations.	Phosphatidylcholines	112-114	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	13-16
12471472-2	2002	We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	60-79	proprotein convertase subtilisin/kexin type 7	Homo sapiens	88-117
12244213-9	2002	These data suggest that CRP binds OxLDL and apoptotic cells by recognition of a PC moiety that becomes accessible as a result of oxidation of PtC molecule.	Phosphatidylcholines	142-145	C-reactive protein	Homo sapiens	24-27
12471472-2	2002	We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	81-83	phospholipase A2 group IB	Homo sapiens	26-32
12471472-2	2002	We recently reported that PLA(2) mediates the hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultures enterocyte monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	81-83	proprotein convertase subtilisin/kexin type 7	Homo sapiens	88-117
12213494-2	2002	Hydrolysis of SL phosphatidylcholine (PC) by PLD2 produces phosphatidic acid (PA), which is then converted to 1,2 diacylglycerol (DAG) by the action of phosphatidate phosphohydrolase type 2 (PAP2).	Phosphatidylcholines	17-36	phospholipase D2	Rattus norvegicus	45-49
12297311-0	2002	Effect of cholesterol on the interaction of seminal plasma protein, PDC-109 with phosphatidylcholine membranes.	Phosphatidylcholines	81-100	seminal plasma protein PDC-109	Bos taurus	44-75
12213494-2	2002	Hydrolysis of SL phosphatidylcholine (PC) by PLD2 produces phosphatidic acid (PA), which is then converted to 1,2 diacylglycerol (DAG) by the action of phosphatidate phosphohydrolase type 2 (PAP2).	Phosphatidylcholines	38-40	phospholipase D2	Rattus norvegicus	45-49
12217395-1	2002	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA).	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
12217395-1	2002	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA).	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
12023904-2	2002	In addition to transferring phosphatidylinositol (PI) and phosphatidylcholine (PC), PITPbeta has been shown to transfer sphingomyelin (SM), and this has led to the suggestion that PITPbeta is important for the regulation of SM metabolism.	Phosphatidylcholines	58-77	phosphatidylinositol transfer protein beta	Homo sapiens	180-188
12221122-4	2002	Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways.	Phosphatidylcholines	102-121	choline/ethanolamine phosphotransferase 1	Homo sapiens	17-22
12221122-4	2002	Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways.	Phosphatidylcholines	102-121	carnitine palmitoyltransferase 1A	Homo sapiens	27-31
12221122-5	2002	CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively.	Phosphatidylcholines	111-130	choline/ethanolamine phosphotransferase 1	Homo sapiens	0-5
12221122-5	2002	CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively.	Phosphatidylcholines	186-205	choline/ethanolamine phosphotransferase 1	Homo sapiens	0-5
12221122-5	2002	CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively.	Phosphatidylcholines	186-205	carnitine palmitoyltransferase 1A	Homo sapiens	169-173
12221122-8	2002	The rate-limiting step for phosphatidylcholine synthesis is catalyzed by the amphitropic CTP:phosphocholine cytidylyltransferase alpha, which is found in the nucleus in most cell types.	Phosphatidylcholines	27-46	phosphate cytidylyltransferase 1A, choline	Homo sapiens	89-134
12221122-10	2002	Thus, substrate channeling of the CDP-choline produced by CTP:phosphocholine cytidylyltransferase alpha to nuclear located CEPT1 is the mechanism by which upregulation of the CDP-choline pathway increases de novo phosphatidylcholine biosynthesis.	Phosphatidylcholines	213-232	phosphate cytidylyltransferase 1A, choline	Homo sapiens	58-103
12221122-10	2002	Thus, substrate channeling of the CDP-choline produced by CTP:phosphocholine cytidylyltransferase alpha to nuclear located CEPT1 is the mechanism by which upregulation of the CDP-choline pathway increases de novo phosphatidylcholine biosynthesis.	Phosphatidylcholines	213-232	choline/ethanolamine phosphotransferase 1	Homo sapiens	123-128
12077151-7	2002	These data suggest that PC, rather than PE and PG, is the major in vivo substrate of PLD alpha.	Phosphatidylcholines	24-26	phospholipase D alpha 1	Arabidopsis thaliana	85-88
12100999-0	2002	CTP:phosphocholine cytidylyltransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcholine.	Phosphatidylcholines	151-170	proline rich transmembrane protein 2	Homo sapiens	44-60
12039969-6	2002	Purified His-cPLA(2)gamma does not exhibit phospholipase A(1) activity, but sequentially hydrolyzes fatty acid from the sn-2 and sn-1 positions of phosphatidylcholine.	Phosphatidylcholines	147-166	phospholipase A2 group IVC	Homo sapiens	13-25
12226489-6	2002	The enzymatic activity of the purified recombinant AtPLA IVA toward phosphatidylcholine was dependent on Ca(2+), saturated at 0.5 mM, and had a pH optimum of about 7.0.	Phosphatidylcholines	68-87	Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein	Arabidopsis thaliana	51-60
12044149-6	2002	Strikingly, the effective length of KALP peptides in the lipid systems investigated here is much smaller than that previously found for the same peptides in phosphatidylcholine.	Phosphatidylcholines	157-176	anosmin 2, pseudogene	Homo sapiens	36-40
12016218-5	2002	Furthermore, the extracellular domain of rat SR-BI fused with human Fc (SRBIecd-Fc) bound to PS with a dissociation equilibrium constant of 2.4 x 10(-7) m in a cell-free solid-phase assay, whereas other phospholipids including phosphatidylethanolamine, phosphatidylinositol, and phosphatidylcholine were poor binding targets.	Phosphatidylcholines	279-298	scavenger receptor class B, member 1	Rattus norvegicus	45-50
12172641-6	2002	Annexin VI purified from rabbit skeletal muscle displayed Ca2+-dependent binding to liposomes containing phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine.	Phosphatidylcholines	147-166	annexin A6	Oryctolagus cuniculus	0-10
12117562-11	2002	The study of PC biosynthetic enzymes showed that PLC inhibitors affect CTP:phosphocholine cytidylyltransferase (CCT) activity while PGD(2) operates on CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CPT), both activities associated to papillary enriched-nuclei fraction.	Phosphatidylcholines	13-15	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	71-110
12117562-11	2002	The study of PC biosynthetic enzymes showed that PLC inhibitors affect CTP:phosphocholine cytidylyltransferase (CCT) activity while PGD(2) operates on CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CPT), both activities associated to papillary enriched-nuclei fraction.	Phosphatidylcholines	13-15	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	112-115
12134061-2	2002	This essential Sec14p requirement for Golgi function is bypassed by mutations in any one of seven genes that control phosphatidylcholine or phosphoinositide metabolism.	Phosphatidylcholines	117-136	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	15-21
11923286-9	2002	For the first time direct observations by atomic force microscopy show (i) that a certain minimal concentration of SP-B is required for the formation of layered protrusions upon film compression, (ii) that protrusion height depends on whether the phospholipids contain an unsaturated fatty acyl chain, and (iii) that protrusion height also depends on whether the unsaturated acyl chain is present in phosphatidylcholine or in phosphatidylglycerol.	Phosphatidylcholines	400-419	surfactant protein B	Homo sapiens	115-119
12021277-4	2002	sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s.	Phosphatidylcholines	49-68	phospholipase A2, group X	Mus musculus	0-7
12021277-4	2002	sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s.	Phosphatidylcholines	49-68	ATPase, class II, type 9A	Mus musculus	290-293
11955950-6	2002	Recently, an oxidized phosphatidylcholine was identified as a potent alternative (patho)physiological natural ligand of PPARgamma.	Phosphatidylcholines	22-41	peroxisome proliferator activated receptor gamma	Homo sapiens	120-129
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Phosphatidylcholines	179-198	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Phosphatidylcholines	179-198	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-56
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Phosphatidylcholines	200-206	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Phosphatidylcholines	200-206	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-56
12052891-10	2002	Activation and nuclear export of CCT alpha were early events in FOH-induced apoptosis that contributed to altered PtdCho synthesis and, in conjunction with caspase cleavage, excluded CCT alpha from the nucleus.	Phosphatidylcholines	114-120	choline-phosphate cytidylyltransferase A	Cricetulus griseus	33-42
12780970-7	2002	MAIN RESULTS: High-intensity xanthine oxidase stress significantly increased type II cell DNA strand breakage, inhibited de novo phosphatidyl choline synthesis, diminished mitochondrial integrity, and enhanced lipid peroxidation in the absence of overt cytolysis.	Phosphatidylcholines	129-149	xanthine dehydrogenase	Mus musculus	29-45
12034570-1	2002	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant.	Phosphatidylcholines	119-138	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
12034570-1	2002	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant.	Phosphatidylcholines	140-142	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
12031288-2	2002	Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic juice.	Phosphatidylcholines	78-97	carboxyl ester lipase	Rattus norvegicus	162-182
12111845-5	2002	Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids.	Phosphatidylcholines	181-200	phospholipase A2 group IIA	Homo sapiens	82-89
12111845-5	2002	Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids.	Phosphatidylcholines	202-204	phospholipase A2 group IIA	Homo sapiens	82-89
12031288-2	2002	Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic juice.	Phosphatidylcholines	99-101	carboxyl ester lipase	Rattus norvegicus	162-182
12031288-4	2002	Cholesterol esterase dose-dependently accelerated the incorporation of cholesterol into differentiated Caco-2 cells, only when cholesterol was solubilized in PC-containing micelles.	Phosphatidylcholines	158-160	carboxyl ester lipase	Homo sapiens	0-20
12031288-9	2002	The addition of cholesterol esterase to bile salt micelles accelerated the release of micellar cholesterol in a dose-dependent manner, only when the micelles contained PC.	Phosphatidylcholines	168-170	carboxyl ester lipase	Homo sapiens	16-36
12054536-6	2002	This is the first evidence for phosphatidylcholine-hydrolyzing phospholipase C in plant signal transduction.	Phosphatidylcholines	31-50	phosphoinositide phospholipase C 2-like	Nicotiana tabacum	63-78
11980474-0	2002	Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria.	Phosphatidylcholines	48-67	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	72-106
11980474-0	2002	Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria.	Phosphatidylcholines	48-67	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	108-113
11980474-9	2002	The significance of the observed interactions between Gut2p and PC is discussed.	Phosphatidylcholines	64-66	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	54-59
12054536-0	2002	Down-regulation by elicitors of phosphatidylcholine-hydrolyzing phospholipase C and up-regulation of phospholipase A in plant cells.	Phosphatidylcholines	32-51	phosphoinositide phospholipase C 2-like	Nicotiana tabacum	64-79
12162465-1	2002	Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline.	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
12054536-4	2002	As phosphatidic acid was only a very minor fluorescent metabolite DAG is hypothesized to arise by the action of a phosphatidylcholine-hydrolyzing phospholipase C which was down-regulated by elicitors.	Phosphatidylcholines	114-133	phosphoinositide phospholipase C 2-like	Nicotiana tabacum	146-161
12059777-5	2002	An enzymatic system is proposed for a cascade of enzymatic reactions simulating lipohydroperoxide metabolism in living cells, including successive free radical oxidation of phosphatidylcholine polyenoic acyls, reduction of their hydroperoxy-derivatives, and hydrolysis of fatty acid residues in the course of catalysis mediated by animal C-15 lipoxygenase, glutathione S-transferase, and phospholipase A(2), respectively.	Phosphatidylcholines	173-192	glutathione S-transferase kappa 1	Homo sapiens	357-382
12162465-1	2002	Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline.	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
12575328-6	2002	CONCLUSION: VIP in the lung may be one of the key regulators involved in the synthesis of phosphatidylcholine mediated by PKC and calmodulin.	Phosphatidylcholines	90-109	vasoactive intestinal peptide	Rattus norvegicus	12-15
12021827-2	2002	Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss.	Phosphatidylcholines	115-134	cut like homeobox 1	Homo sapiens	62-65
12021827-2	2002	Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss.	Phosphatidylcholines	136-142	cut like homeobox 1	Homo sapiens	62-65
12575328-6	2002	CONCLUSION: VIP in the lung may be one of the key regulators involved in the synthesis of phosphatidylcholine mediated by PKC and calmodulin.	Phosphatidylcholines	90-109	calmodulin 1	Rattus norvegicus	130-140
11973292-1	2002	Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation.	Phosphatidylcholines	34-53	phospholipase D	Saccharomyces cerevisiae S288C	25-30
11919088-10	2002	These data suggest that the cell-cycle changes in PC synthesis are likely not due to alterations in CCTalpha expression and degradation but are primarily a consequence of changes in CCTalpha activity, phosphorylation, and membrane affinity.	Phosphatidylcholines	50-52	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	182-190
11796736-3	2002	The model building, electrostatic potential calculation, and in vitro membrane binding studies of the isolated C2-like domain of 5-LO and selected mutants show that this Ca(2+)-dependent domain selectively binds zwitterionic phosphatidylcholine, which is conferred by tryptophan residues (Trp(13), Trp(75), and Trp(102)) located in the putative Ca(2+)-binding loops.	Phosphatidylcholines	225-244	arachidonate 5-lipoxygenase	Homo sapiens	129-133
11796736-4	2002	The spatiotemporal dynamics of the enhanced green fluorescence protein-tagged C2-like domain of 5-LO and mutants in living cells also show that the phosphatidylcholine selectivity of the C2-like domain accounts for the specific targeting of 5-LO to the nuclear envelope.	Phosphatidylcholines	148-167	arachidonate 5-lipoxygenase	Homo sapiens	96-100
11796736-4	2002	The spatiotemporal dynamics of the enhanced green fluorescence protein-tagged C2-like domain of 5-LO and mutants in living cells also show that the phosphatidylcholine selectivity of the C2-like domain accounts for the specific targeting of 5-LO to the nuclear envelope.	Phosphatidylcholines	148-167	arachidonate 5-lipoxygenase	Homo sapiens	241-245
11880299-1	2002	Tumor necrosis factor (TNF)-alpha is a major cytokine implicated in inducing acute and chronic lung injury, conditions associated with surfactant phosphatidylcholine (PtdCho) deficiency.	Phosphatidylcholines	146-165	tumor necrosis factor	Mus musculus	0-33
11880299-1	2002	Tumor necrosis factor (TNF)-alpha is a major cytokine implicated in inducing acute and chronic lung injury, conditions associated with surfactant phosphatidylcholine (PtdCho) deficiency.	Phosphatidylcholines	167-173	tumor necrosis factor	Mus musculus	0-33
11880299-2	2002	Acutely, TNF-alpha decreases PtdCho synthesis but stimulates surfactant secretion.	Phosphatidylcholines	29-35	tumor necrosis factor	Mus musculus	9-18
11880299-9	2002	Reduced parenchymal PtdCho synthesis appears to be attributed to CCT enzyme that is physiologically inactivated by ceramide or by diminished availability of activating lipids.	Phosphatidylcholines	20-26	t-complex protein 1	Mus musculus	65-68
11951953-1	2002	The interaction of the chemical carcinogen benzo[a]pyrene (BaP) with phosphatidylcholine membranes has been investigated by using various physical techniques.	Phosphatidylcholines	69-88	prohibitin 2	Homo sapiens	59-62
11919173-7	2002	ET-18-OCH3 also inhibited PtdCho synthesis.	Phosphatidylcholines	26-32	ochre	Mus musculus	6-9
11973292-1	2002	Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation.	Phosphatidylcholines	34-53	phospholipase D	Saccharomyces cerevisiae S288C	114-129
11973292-1	2002	Saccharomyces cerevisiae Spo14, a phosphatidylcholine-specific, phosphatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spore formation.	Phosphatidylcholines	34-53	phospholipase D	Saccharomyces cerevisiae S288C	131-134
12013527-0	2002	Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.	Phosphatidylcholines	38-57	PCNA clamp associated factor	Rattus norvegicus	8-34
12024107-2	2002	In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs).	Phosphatidylcholines	67-86	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	269-275
12024107-2	2002	In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs).	Phosphatidylcholines	67-86	matrix metallopeptidase 13	Rattus norvegicus	281-308
12024107-2	2002	In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs).	Phosphatidylcholines	67-86	matrix metallopeptidase 13	Rattus norvegicus	310-316
12191592-2	2002	PLD metabolizes phosphatidylcholine to generate phosphatidic acid (PA).	Phosphatidylcholines	16-35	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
11916983-3	2002	Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast phosphatidylinositol/phosphatidylcholine Sec14p.	Phosphatidylcholines	182-201	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	0-5
11916983-3	2002	Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast phosphatidylinositol/phosphatidylcholine Sec14p.	Phosphatidylcholines	182-201	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	202-208
12013527-2	2002	PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted).	Phosphatidylcholines	14-33	PCNA clamp associated factor	Rattus norvegicus	0-3
12013527-2	2002	PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted).	Phosphatidylcholines	128-147	PCNA clamp associated factor	Rattus norvegicus	0-3
12013527-2	2002	PAF increased phosphatidylcholine secretion in a concentration-dependent manner in the 10(-5) - 10(-10) M range, with a maximum phosphatidylcholine secretion of up to 3.3 fold the basal values (3.4 +/- 0.3% phosphatidylcholine secreted).	Phosphatidylcholines	128-147	PCNA clamp associated factor	Rattus norvegicus	0-3
12013527-4	2002	A study of the mechanism through which PAF exerts its stimulatory effect was carried out adding different agents that are well known stimulants of phosphatidylcholine secretion.	Phosphatidylcholines	147-166	PCNA clamp associated factor	Rattus norvegicus	39-42
12013527-5	2002	Thus, PAF increased the TPA- and terbutaline-stimulated phosphatidylcholine secretion, that are PKC and PKA activators respectively, suggesting the involvement of both protein kinases in the process.	Phosphatidylcholines	56-75	PCNA clamp associated factor	Rattus norvegicus	6-9
12449015-4	2002	The PAFR recognizes the short residue, an acetate residue, at the 2-position of the phospholipid, and this sharp specificity precludes receptor activation by other related phosphatidylcholines.	Phosphatidylcholines	172-192	platelet activating factor receptor	Homo sapiens	4-8
12449015-7	2002	Oxidation of LDLs fragments and derivatizes the fatty acid residues at the 2-position of the phosphatidylcholines that comprise the shell of LDLs, an event that allows certain oxidized phospholipids to interact with and activate the PAFR.	Phosphatidylcholines	93-113	platelet activating factor receptor	Homo sapiens	233-237
11960751-1	2002	Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver.	Phosphatidylcholines	119-138	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-46
11960751-1	2002	Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver.	Phosphatidylcholines	119-138	phosphatidylethanolamine N-methyltransferase	Homo sapiens	48-53
11960751-1	2002	Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver.	Phosphatidylcholines	119-138	phosphatidylethanolamine N-methyltransferase	Homo sapiens	48-52
11855861-1	2002	The phosphatidylcholine transfer protein (PC-TP) is a specific transporter of phosphatidylcholine (PC) between membranes.	Phosphatidylcholines	4-23	phosphatidylcholine transfer protein	Homo sapiens	42-47
11841283-2	2002	Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine.	Phosphatidylcholines	160-179	polypyrimidine tract binding protein 3	Homo sapiens	38-43
11839534-5	2002	IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose.	Phosphatidylcholines	81-100	interleukin-1 alpha	Ovis aries	0-10
11839534-5	2002	IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose.	Phosphatidylcholines	81-100	interleukin-1 beta	Ovis aries	15-24
11891260-1	2002	Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains.	Phosphatidylcholines	46-65	phospholipase D P1	Arabidopsis thaliana	76-86
11880242-1	2002	Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways.	Phosphatidylcholines	65-84	cut-like homeobox 1	Rattus norvegicus	140-143
11880242-1	2002	Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways.	Phosphatidylcholines	65-84	cut-like homeobox 1	Rattus norvegicus	156-159
11880242-1	2002	Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways.	Phosphatidylcholines	86-90	cut-like homeobox 1	Rattus norvegicus	140-143
11880242-1	2002	Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways.	Phosphatidylcholines	86-90	cut-like homeobox 1	Rattus norvegicus	156-159
11880242-2	2002	In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT).	Phosphatidylcholines	40-44	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	48-72
11880242-2	2002	In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT).	Phosphatidylcholines	40-44	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	74-78
11751880-1	2002	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein of unknown function that catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	129-149	phosphatidylcholine transfer protein	Cricetulus griseus	0-36
11751880-1	2002	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein of unknown function that catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	129-149	phosphatidylcholine transfer protein	Cricetulus griseus	38-43
11751880-8	2002	These findings suggest that a physiological function of PC-TP is to replenish the plasma membrane with phosphatidylcholines that are removed during pre-beta-HDL particle formation due to the activity of ATP-binding cassette A1.	Phosphatidylcholines	103-123	phosphatidylcholine transfer protein	Cricetulus griseus	56-61
12033451-3	2002	In this study we investigated the oxidation of various substrates (linoleic acid, methyl linoleate, phosphatidylcholine, isolated LDL, and human plasma) by the arachidonate 15-lipoxygenases from rabbit reticulocytes and soybeans aiming at elucidating the effects of substrate, lipoxygenase and reaction milieu on the contribution and mechanism of random oxidation and also the effect of antioxidant.	Phosphatidylcholines	100-119	linoleate 9S-lipoxygenase-4	Glycine max	176-188
12033451-6	2002	When phosphatidylcholine liposomes and LDL were oxygenated by soybean lipoxygenase, the product pattern was found to be exclusively regio-, stereo-, and enantio-random.	Phosphatidylcholines	5-24	linoleate 9S-lipoxygenase-4	Glycine max	70-82
11880242-7	2002	Of the newly synthesized PtdC, about 70% was derived de novo and 30% was by PEMT.	Phosphatidylcholines	25-29	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	76-80
11829742-0	2002	Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter.	Phosphatidylcholines	39-58	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	122-161
11829742-1	2002	Lipid-deprived mice increase alveolar surfactant disaturated phosphatidylcholine (DSPtdCho) synthesis compared with mice fed a standard diet by increasing expression of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme for DSPtdCho synthesis.	Phosphatidylcholines	61-80	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	169-208
12186778-4	2002	Phosphatidylcholine and phosphatidylethanolamine, the major constituents of the mitochondrial inner membrane, stimulated purified Endo G activity 5- to 10-fold.	Phosphatidylcholines	0-19	endonuclease G	Homo sapiens	130-136
11853701-2	2002	A significant increase in phosphatidylcholine (PC) labeling was observed when cortical slices, prelabeled with [32P]orthophosphate, were incubated for 30 min in the presence of Ang-(1-7) (1 pM to 100 nM).	Phosphatidylcholines	26-45	angiogenin	Rattus norvegicus	177-185
11853701-2	2002	A significant increase in phosphatidylcholine (PC) labeling was observed when cortical slices, prelabeled with [32P]orthophosphate, were incubated for 30 min in the presence of Ang-(1-7) (1 pM to 100 nM).	Phosphatidylcholines	47-49	angiogenin	Rattus norvegicus	177-185
11853701-5	2002	However, losartan potentiated the effect of 100 nM Ang-(1-7) on PC biosynthesis.	Phosphatidylcholines	64-66	angiogenin	Rattus norvegicus	51-59
11772399-3	2002	Fluorescence emission spectra for the single Trp residue of SLN suggest that SLN incorporates fully into bilayers of dioleoylphosphatidylcholine, but only partially into bilayers of phosphatidylcholines with long (C(22) or C(24)) fatty acyl chains.	Phosphatidylcholines	182-202	sarcolipin	Homo sapiens	60-63
11802709-3	2002	The cooperative binding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces docking to phosphatidylcholine (PC) membranes.	Phosphatidylcholines	127-146	phospholipase A2 group IVA	Homo sapiens	63-91
11802709-3	2002	The cooperative binding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces docking to phosphatidylcholine (PC) membranes.	Phosphatidylcholines	148-150	phospholipase A2 group IVA	Homo sapiens	63-91
11805144-10	2002	In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression.	Phosphatidylcholines	210-229	platelet-activating factor receptor	Mus musculus	99-111
11805144-10	2002	In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression.	Phosphatidylcholines	210-229	patchy fur	Mus musculus	99-102
11805144-10	2002	In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression.	Phosphatidylcholines	210-229	patchy fur	Mus musculus	99-102
11772399-3	2002	Fluorescence emission spectra for the single Trp residue of SLN suggest that SLN incorporates fully into bilayers of dioleoylphosphatidylcholine, but only partially into bilayers of phosphatidylcholines with long (C(22) or C(24)) fatty acyl chains.	Phosphatidylcholines	182-202	sarcolipin	Homo sapiens	77-80
11673871-4	2001	In addition to requiring Smad activity, based upon the effects of specific inhibitors, the TGF-beta intracellular signaling pathway requires the activity of a phosphatidylcholine-specific phospholipase C, a protein kinase C, and one or more tyrosine kinases.	Phosphatidylcholines	159-178	transforming growth factor beta 1	Homo sapiens	91-99
11796739-1	2002	Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain.	Phosphatidylcholines	97-116	cut like homeobox 1	Homo sapiens	44-47
11796739-1	2002	Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain.	Phosphatidylcholines	118-124	cut like homeobox 1	Homo sapiens	44-47
11741598-1	2001	Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A(2) (sPLA(2)-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types.	Phosphatidylcholines	45-64	phospholipase A2, group X	Mus musculus	66-101
11741598-1	2001	Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A(2) (sPLA(2)-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types.	Phosphatidylcholines	45-64	phospholipase A2, group X	Mus musculus	104-113
11814059-1	2001	A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate.	Phosphatidylcholines	82-102	phospholipid transfer protein	Oryctolagus cuniculus	9-38
11814059-1	2001	A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate.	Phosphatidylcholines	82-102	phospholipid transfer protein	Oryctolagus cuniculus	40-48
11814059-1	2001	A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate.	Phosphatidylcholines	104-106	phospholipid transfer protein	Oryctolagus cuniculus	9-38
11814059-1	2001	A 36-kDa phospholipid transfer protein (PLT-P(R)), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate.	Phosphatidylcholines	104-106	phospholipid transfer protein	Oryctolagus cuniculus	40-48
11546763-5	2001	In GPAT-overexpressing cells, the incorporation of label into phospholipid, particularly phosphatidylcholine, decreased 30%, despite normal growth rate and phospholipid content, suggesting that exogenous oleate was directed primarily toward triacylglycerol synthesis.	Phosphatidylcholines	89-108	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	3-7
11779181-0	2002	Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite.	Phosphatidylcholines	58-77	paraoxonase 1	Homo sapiens	24-37
11779181-7	2002	In addition, PON-1 hydrolyzed the phosphatidylcholine core aldehydes 1-palmitoyl-2-(9-oxo)nonanoyl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-(5-oxo)valeroyl-sn-glycero-3-phosphocholine to lysophosphatidylcholine.	Phosphatidylcholines	34-53	paraoxonase 1	Homo sapiens	13-18
11779181-10	2002	We conclude that PON-1 minimizes the accumulation of phosphatidylcholine oxidation products by the hydrolysis of phosphatidylcholine isoprostanes and core aldehydes to lysophosphatidylcholine with a serine esterase-independent mechanism.	Phosphatidylcholines	53-72	paraoxonase 1	Homo sapiens	17-22
11902115-7	2002	Of special interest was the prevalence of phospholipids (phosphatidylcholine, diacyl-phosphatidylethanolamine, and phosphatidylserine) with 22:6n-3 in both the sn-1 and sn-2 positions of SPM and these phospholipid species were significantly higher in apoE-deficient mice as compared to control mice.	Phosphatidylcholines	57-76	solute carrier family 38, member 3	Mus musculus	160-164
12043230-3	2002	sPLA2 was measured with enzyme immunoassay, catalytic activity--using aqueous emulsion of 14C-labelled phosphatidylcholine.	Phosphatidylcholines	103-122	phospholipase A2 group X	Homo sapiens	0-5
11583989-1	2001	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	99-118	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
11583989-1	2001	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	99-118	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
11583989-1	2001	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	120-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
11583989-1	2001	CTP:phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo synthesis of phosphatidylcholine (PC).	Phosphatidylcholines	120-122	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	41-44
11583989-5	2001	The unusual requirements of the lung for PC synthesis and, therefore, CCT activity suggest a unique mechanism of regulation and possibly localization of CCT.	Phosphatidylcholines	41-43	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	153-156
11721001-3	2001	Colipase adsorption rates to phosphatidylcholine/reactant mixed monolayers depended strongly on lipid composition and packing.	Phosphatidylcholines	29-48	colipase	Homo sapiens	0-8
11721001-4	2001	Paradoxically, reactants lowered colipase adsorption rates only if phosphatidylcholine was present.	Phosphatidylcholines	67-86	colipase	Homo sapiens	33-41
11721001-5	2001	This suggests that interactions between phosphatidylcholine and reactants create dynamic complexes that impede colipase adsorption.	Phosphatidylcholines	40-59	colipase	Homo sapiens	111-119
11721001-7	2001	Colipase binding rate depends nonlinearly on the two-dimensional concentration of phosphatidylcholine.	Phosphatidylcholines	82-101	colipase	Homo sapiens	0-8
11908825-2	2001	Ethanolic solution of Gb3 containing cholesterol and phosphatidylcholine was passively adsorbed onto the wells of microtiter plate, and Gb3-bound VT1 and VT2 were detected by anti-VT1 and anti-VT2 mAbs, respectively.	Phosphatidylcholines	53-72	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	22-25
11750883-10	2001	Repeated washing of the microsomal freeze-dried fraction with benzene resulted in a complete loss of DAGAT activity in the standard assay, but the activity was restored by the addition of DAG plus phosphatidylcholine or Tween 20 in benzene.	Phosphatidylcholines	197-216	Diacylglycerol O-acyltransferase 1-2	Zea mays	101-106
11564739-10	2001	Catabolism of all major HDL lipids can occur via SR-BI with the relative selective uptake rate constants for CE, free cholesterol, triglycerides (triolein), and phosphatidylcholine being 1, 1.6, 0.7, and 0.2, respectively.	Phosphatidylcholines	161-180	scavenger receptor class B member 1	Homo sapiens	49-54
11533033-3	2001	To better understand apoE-lipid interactions on lipoprotein surfaces, we determined the thermodynamic parameters for binding of apoE4 and its 22- and 10-kDa fragments to triolein-egg phosphatidylcholine emulsions using a centrifugation assay and titration calorimetry.	Phosphatidylcholines	183-202	apolipoprotein E	Homo sapiens	128-133
11694619-5	2001	Uptake of micellar beta-carotene and lutein was greatly suppressed by phosphatidylcholine (PC) in a dose-dependent manner, whereas lysophosphatidylcholine (lysoPC), the lipolysis product of PC by phospholipase A2 (PLA2), markedly enhanced both beta-carotene and lutein uptake.	Phosphatidylcholines	91-93	phospholipase A2 group IB	Homo sapiens	196-212
11694619-6	2001	The addition of PLA2 from porcine pancreas to the medium also enhanced the uptake of carotenoids from micelles containing PC.	Phosphatidylcholines	122-124	phospholipase A2 group IB	Homo sapiens	16-20
11694619-5	2001	Uptake of micellar beta-carotene and lutein was greatly suppressed by phosphatidylcholine (PC) in a dose-dependent manner, whereas lysophosphatidylcholine (lysoPC), the lipolysis product of PC by phospholipase A2 (PLA2), markedly enhanced both beta-carotene and lutein uptake.	Phosphatidylcholines	91-93	phospholipase A2 group IB	Homo sapiens	214-218
11758754-0	2001	Distribution and diffusion of sodium taurocholate and egg phosphatidylcholine aggregates in rat intestinal mucin.	Phosphatidylcholines	58-77	solute carrier family 13 member 2	Rattus norvegicus	107-112
11762137-5	2001	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction.	Phosphatidylcholines	102-121	phosphatidylethanolamine N-methyltransferase	Homo sapiens	11-53
11762137-5	2001	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction.	Phosphatidylcholines	102-121	phosphatidylethanolamine N-methyltransferase	Homo sapiens	55-59
11762137-5	2001	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction.	Phosphatidylcholines	123-125	phosphatidylethanolamine N-methyltransferase	Homo sapiens	11-53
11762137-5	2001	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction.	Phosphatidylcholines	123-125	phosphatidylethanolamine N-methyltransferase	Homo sapiens	55-59
11758754-1	2001	PURPOSE: The permeability of rat intestinal mucin (RIM) to sodium taurocholate/egg phosphatidylcholine (TC/PC)-mixed micelles has been investigated.	Phosphatidylcholines	83-102	solute carrier family 13 member 2	Rattus norvegicus	44-49
11504713-4	2001	Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates.	Phosphatidylcholines	27-46	surfactant associated protein A1	Mus musculus	76-80
11745043-1	2001	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.	Phosphatidylcholines	158-177	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	48-52
11745043-1	2001	Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.	Phosphatidylcholines	158-177	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	65-69
11504713-4	2001	Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates.	Phosphatidylcholines	27-46	surfactant protein A1	Rattus norvegicus	85-90
11504713-4	2001	Tissue levels of saturated phosphatidylcholine were slightly reduced in the SP-A(-/-,rSP-A) mice compared with SP-A(-/-) littermates.	Phosphatidylcholines	27-46	surfactant associated protein A1	Mus musculus	86-90
11591753-1	2001	We have recently shown that IL-3R occupancy activates a phosphatidylcholine-specific phospholipase C, and the sustained diacylglycerol accumulation subsequently activates protein kinase C (PKC).	Phosphatidylcholines	56-75	interleukin 3 receptor subunit alpha	Homo sapiens	28-33
11580285-1	2001	The conformation and amide proton exchangeability of the peptide acetyl-K(2)-A(24)-K(2)-amide (A(24)) and its interaction with phosphatidylcholine bilayers were examined by a variety of physical techniques.	Phosphatidylcholines	127-146	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	77-82
11580285-1	2001	The conformation and amide proton exchangeability of the peptide acetyl-K(2)-A(24)-K(2)-amide (A(24)) and its interaction with phosphatidylcholine bilayers were examined by a variety of physical techniques.	Phosphatidylcholines	127-146	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	95-100
11580285-6	2001	Also, when dispersed with phosphatidylcholine in aqueous media, the conformation and thermal stability of A(24) are not significantly altered by the presence of the phospholipid or by its gel/liquid-crystalline phase transition.	Phosphatidylcholines	26-45	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	106-111
11590214-2	2001	The principal acceptors of unesterified cholesterol (UC) from cultured cells are small pre-beta-HDL, which we have shown increase in plasma during intravenous infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs in humans.	Phosphatidylcholines	190-209	apolipoprotein A1	Homo sapiens	211-220
11557604-8	2001	[(3)H]choline incorporation into total phosphatidylcholine was increased by VEGF treatment, but incorporation into disaturated phosphatidylcholine was not affected by exogenous VEGF.	Phosphatidylcholines	39-58	vascular endothelial growth factor A	Homo sapiens	76-80
11706993-1	2001	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11706993-1	2001	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11563837-0	2001	Role of calcium-independent phospholipases (iPLA(2)) in phosphatidylcholine metabolism.	Phosphatidylcholines	56-75	phospholipase A2, group VI	Mus musculus	44-51
11590219-1	2001	We have previously identified a single amino acid mutation (hE149A) in human LCAT that increases its in vitro reactivity with phosphatidylcholine species containing sn-2 arachidonate (Wang et al.	Phosphatidylcholines	126-145	lecithin-cholesterol acyltransferase	Homo sapiens	77-81
11768152-2	2001	In general, monoenoic and dienoic acids are found in the sn-2 acyl chain of phosphatidylcholine (PtdCho), whereas polyenoic acids are in phosphatidylethanolamine (PtdEth).	Phosphatidylcholines	76-95	solute carrier family 38 member 5	Homo sapiens	57-61
11768161-6	2001	The c9,t11-CLA isomer decreased (P &lt; 0.05) uptake of 14C-AA into phosphatidylcholine while increasing (P &lt; 0.05) uptake into phosphatidylethanolamine in both cell lines.	Phosphatidylcholines	68-87	complement C9	Homo sapiens	4-14
11563837-1	2001	The proposed role of calcium-independent phospholipase A(2) (iPLA(2)) in membrane phospholipid homeostasis was tested by examining the perturbation of phosphatidylcholine metabolism by enzyme overexpression.	Phosphatidylcholines	151-170	phospholipase A2, group VI	Mus musculus	21-59
11563837-1	2001	The proposed role of calcium-independent phospholipase A(2) (iPLA(2)) in membrane phospholipid homeostasis was tested by examining the perturbation of phosphatidylcholine metabolism by enzyme overexpression.	Phosphatidylcholines	151-170	phospholipase A2, group VI	Mus musculus	61-68
11530878-2	2001	One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD).	Phosphatidylcholines	196-215	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	219-234
11523993-6	2001	Differential scanning calorimetry results demonstrate that NAP-22 promotes domain formation in liposomes composed of cholesterol and phosphatidylcholine.	Phosphatidylcholines	133-152	brain abundant membrane attached signal protein 1	Homo sapiens	59-65
11523993-7	2001	This is shown by NAP-22-promoted changes in the shape and enthalpy of the phase transition of phosphatidylcholine as well as by the appearance of cholesterol crystallite transitions in membranes composed of phosphatidylcholine with either saturated or unsaturated acyl chains.	Phosphatidylcholines	94-113	brain abundant membrane attached signal protein 1	Homo sapiens	17-23
11549244-5	2001	APF/CBP (0.1 to 2.4 microg/ml) inhibited ApoA-1 (2 microg/ml) mediated cholesterol efflux from normal fibroblasts in a dose dependent manner but had no effect on aspecific efflux to methyl-beta-cyclodextrin or phosphatidylcholine liposomes.	Phosphatidylcholines	210-229	CREB binding protein	Homo sapiens	4-7
11420051-3	2001	Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase.	Phosphatidylcholines	30-32	phospholipase A2 group IB	Rattus norvegicus	184-200
11420051-3	2001	Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase.	Phosphatidylcholines	30-32	phospholipase A2 group IB	Rattus norvegicus	202-206
11530878-2	2001	One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD).	Phosphatidylcholines	196-215	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	236-239
11536170-6	2001	Recruitment of the gamma chain either by FcgammaRI in cytokine-primed cells or by FcalphaRI in dbcAMP-induced cells couples ligand binding to the activation of phosphatidyl choline-specific phospholipase D.	Phosphatidylcholines	160-180	Fc alpha receptor	Homo sapiens	82-91
11470084-4	2001	In the fluid phase region, the outer hyperfine splitting increases for all phosphatidylcholine spin-label positional isomers, indicating that the chain mobility is decreased by binding avidin.	Phosphatidylcholines	75-94	spindlin 1	Homo sapiens	95-99
11552739-6	2001	Treated cells processed pro-SP-B and pro-SP-C proteins to mature forms and had a higher rate of phosphatidylcholine (PC) synthesis (2-fold) and higher saturation of PC (approximately 34% versus 27%) than controls.	Phosphatidylcholines	117-119	surfactant protein C	Homo sapiens	41-45
11566147-3	2001	The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+).	Phosphatidylcholines	75-94	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	106-150
11566147-3	2001	The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+).	Phosphatidylcholines	75-94	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	152-156
11566147-3	2001	The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+).	Phosphatidylcholines	96-99	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	106-150
11566147-3	2001	The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+).	Phosphatidylcholines	96-99	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	152-156
11478786-1	2001	Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD.	Phosphatidylcholines	35-54	superoxide dismutase 1	Homo sapiens	86-106
11478786-1	2001	Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD.	Phosphatidylcholines	35-54	superoxide dismutase 1	Homo sapiens	149-152
11478786-1	2001	Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD.	Phosphatidylcholines	35-54	superoxide dismutase 1	Homo sapiens	108-111
11478786-1	2001	Covalent binding of 4 molecules of phosphatidylcholine palmitoyl to human recombinant superoxide dismutase (SOD) results in a compound (lecithinized SOD) that has a longer half-life and greater affinity to the cell membrane than unmodified SOD.	Phosphatidylcholines	35-54	superoxide dismutase 1	Homo sapiens	149-152
11483407-4	2001	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D 609) attenuated TNF-alpha-induced ICAM-1 expression.	Phosphatidylcholines	59-78	tumor necrosis factor	Homo sapiens	142-151
11502229-5	2001	SAMP8 fed the PC combined with vitamin B12 diet had an increased PKC activity and a higher proportion of 22 : 6n-3 than SAMP8 fed the control diet.	Phosphatidylcholines	14-16	protein kinase C, beta	Mus musculus	65-68
11483407-4	2001	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D 609) attenuated TNF-alpha-induced ICAM-1 expression.	Phosphatidylcholines	59-78	intercellular adhesion molecule 1	Homo sapiens	160-166
11514437-1	2001	In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid.	Phosphatidylcholines	107-126	phospholipase D	Saccharomyces cerevisiae S288C	29-44
11514437-7	2001	Choline and phosphatidic acid molecular species profiles during Sec14-independent secretion and meiosis reveal that while strains harboring one of these alleles, spo14S-11, hydrolyze phosphatidylcholine in Sec14-independent secretion, they fail to do so during sporulation or normal vegetative growth.	Phosphatidylcholines	183-202	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	64-69
11551535-3	2001	An essential factor in the activation of PC-TP was phosphatidylcholine (PC) present in the folding buffer.	Phosphatidylcholines	51-70	phosphatidylcholine transfer protein	Bos taurus	41-46
11514437-7	2001	Choline and phosphatidic acid molecular species profiles during Sec14-independent secretion and meiosis reveal that while strains harboring one of these alleles, spo14S-11, hydrolyze phosphatidylcholine in Sec14-independent secretion, they fail to do so during sporulation or normal vegetative growth.	Phosphatidylcholines	183-202	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	206-211
11514437-8	2001	These results demonstrate that Spo14 PLD catalytic activity and cellular function can be differentially regulated at the level of phosphatidylcholine hydrolysis.	Phosphatidylcholines	130-149	phospholipase D	Saccharomyces cerevisiae S288C	31-36
11514437-8	2001	These results demonstrate that Spo14 PLD catalytic activity and cellular function can be differentially regulated at the level of phosphatidylcholine hydrolysis.	Phosphatidylcholines	130-149	phospholipase D	Saccharomyces cerevisiae S288C	37-40
11514437-1	2001	In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid.	Phosphatidylcholines	107-126	phospholipase D	Saccharomyces cerevisiae S288C	46-49
11514437-1	2001	In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid.	Phosphatidylcholines	107-126	phospholipase D	Saccharomyces cerevisiae S288C	67-72
11320081-2	2001	However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified.	Phosphatidylcholines	71-90	paraoxonase 1	Homo sapiens	61-66
11535107-2	2001	A variety of in vitro and in vivo studies, performed by multiple laboratories, suggest that the lipid substrates of this enzyme, PAF and oxidised derivatives of phosphatidylcholines, play important roles as causative factors in many diseases including asthma.	Phosphatidylcholines	161-181	PCNA clamp associated factor	Homo sapiens	129-132
11331277-7	2001	In cell culture experiments, phosphatidylcholine-containing liposomes competed efficiently with LDL for binding to LPL.	Phosphatidylcholines	29-48	lipoprotein lipase	Homo sapiens	115-118
11320081-0	2001	Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.	Phosphatidylcholines	45-64	apolipoprotein A1	Homo sapiens	0-18
11320081-8	2001	Incubation of apolipoprotein A-I with 1-palmitoyl-2-linoleoyl glycerophosphocholine proteoliposomes in the presence of 3-morpholinosydnonimine or apoAI with phosphatidylcholine hydroperoxides resulted in a significant increase in phosphatidylcholine core aldehydes with no formation of lysophosphatidylcholine.	Phosphatidylcholines	157-176	apolipoprotein A1	Homo sapiens	14-32
11320081-0	2001	Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.	Phosphatidylcholines	45-64	paraoxonase 1	Homo sapiens	116-121
11320081-10	2001	Purified PON-1 hydrolyzed phosphatidylcholine core aldehydes to lysophosphatidylcholine.	Phosphatidylcholines	26-45	paraoxonase 1	Homo sapiens	9-14
11320081-2	2001	However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified.	Phosphatidylcholines	71-90	apolipoprotein A1	Homo sapiens	23-41
11320081-2	2001	However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified.	Phosphatidylcholines	71-90	paraoxonase 1	Homo sapiens	46-59
11320081-11	2001	We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1.	Phosphatidylcholines	102-121	apolipoprotein A1	Homo sapiens	57-74
11320081-11	2001	We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1.	Phosphatidylcholines	102-121	paraoxonase 1	Homo sapiens	173-177
11312259-6	2001	Stern-Volmer analysis of the quenching of PT-(1-46)F4W in the presence and absence of 80% phosphatidylcholine/20% PS vesicles suggested that Trp-4 is positioned within the membrane and protected from aqueous quenching agents whereas Trp-41 remains solvent-accessible in the presence of PS-containing vesicles.	Phosphatidylcholines	90-109	transient receptor potential cation channel subfamily C member 4	Homo sapiens	141-146
11435917-8	2001	These results indicate that orexin-A increases [Ca2+]i in VTA dopamine neurons via phosphatidylcholine-specific PLC- and PKC-mediated activation of L- and N-type Ca2+ channels.	Phosphatidylcholines	83-102	hypocretin neuropeptide precursor	Rattus norvegicus	28-36
11404253-2	2001	Am J Physiol Lung Cell Mol Physiol 281: L98-L107, 2001), we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin.	Phosphatidylcholines	237-256	tumor necrosis factor	Homo sapiens	78-111
11404253-2	2001	Am J Physiol Lung Cell Mol Physiol 281: L98-L107, 2001), we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin.	Phosphatidylcholines	258-260	tumor necrosis factor	Homo sapiens	78-111
11423412-7	2001	A large fraction (~75%) of the reconstituted t-SNARE was laterally mobile with a lateral diffusion coefficient of 7.5 x 10(-9) cm(2)/s in a phosphatidylcholine lipid background.	Phosphatidylcholines	140-159	small NF90 (ILF3) associated RNA E	Homo sapiens	47-52
11518575-1	2001	The interaction of sodium taurocholate/egg phosphatidylcholine (TC/PC) micelles with mucin was determined to investigate the exclusion of lipids by mucus in the absorption process.	Phosphatidylcholines	43-62	solute carrier family 13 member 2	Rattus norvegicus	85-90
11521966-0	2001	Regulation of intestinal apolipoprotein A-I synthesis by dietary phosphatidylcholine in newborn swine.	Phosphatidylcholines	65-84	apolipoprotein A1	Sus scrofa	25-43
11416880-2	2001	During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and glucocorticoids stimulate the production of surfactant-associated proteins and increase phospholipid synthesis by enhancing the activity of phosphatidylcholine.	Phosphatidylcholines	228-247	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-51
11442029-1	2001	We have modified a reversed-phase (RP8) column by passing through it an aqueous solution of phosphatidylcholine-based liposomes.	Phosphatidylcholines	92-111	programmed cell death 2	Homo sapiens	35-38
11294854-2	2001	Analysis of erythrocyte phospholipid metabolism by thin-layer chromatography revealed significant hydrolysis of both phosphatidylcholine and phosphatidylethanolamine during incubation with ionomycin and sPLA(2).	Phosphatidylcholines	117-136	phospholipase A2 group X	Homo sapiens	203-210
11500953-12	2001	In conclusion, the results of the present study indicate that in MC3T3-E1 osteoblast-like cells, ET-1 acting through ET receptor links to a stimulation of Pi transport via activation of PKC through both phosphoinositide and phosphatidylcholine hydrolyses.	Phosphatidylcholines	224-243	endothelin 1	Mus musculus	97-101
11376003-1	2001	Previous studies suggest that the steps of the CDP- choline pathway of phosphatidylcholine synthesis are tightly linked in a so-called metabolon.	Phosphatidylcholines	71-90	cut like homeobox 1	Homo sapiens	47-50
11389609-6	2001	P-Glycoprotein exhibited a broad specificity for phospholipids, and translocated phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin.	Phosphatidylcholines	81-100	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
11410291-10	2001	In addition, we examined the effect of several known enzyme modulators, namely carbenoxolone, phenylarsine oxide and phosphatidylcholine, on 11-cis-retinol dehydrogenase activity.	Phosphatidylcholines	117-136	retinol dehydrogenase 5	Homo sapiens	141-169
11400861-0	2001	Metabolism of surfactant phosphatidylcholine molecular species in cftr(tm1HGU/tm1HGU) mice compared to MF-1 mice.	Phosphatidylcholines	25-44	cystic fibrosis transmembrane conductance regulator	Mus musculus	66-70
11400861-8	2001	In BALF from cftr(tmIHGU/m1HGU) mice, the [methyl-3H]choline label of total PC and individual PC species was significantly increased over control values after 24 hours, but not after 1.5 to 6 hours.	Phosphatidylcholines	76-78	cystic fibrosis transmembrane conductance regulator	Mus musculus	13-17
11400861-8	2001	In BALF from cftr(tmIHGU/m1HGU) mice, the [methyl-3H]choline label of total PC and individual PC species was significantly increased over control values after 24 hours, but not after 1.5 to 6 hours.	Phosphatidylcholines	94-96	cystic fibrosis transmembrane conductance regulator	Mus musculus	13-17
11336647-8	2001	Liposomes of phosphatidylcholine, phosphatidylserine and their mixture increased secondary structure of 63-193 StAR at pH 7, as monitored by far-UV CD, and stable protein-liposome complexes were identified by gel-permeation chromatography.	Phosphatidylcholines	13-32	steroidogenic acute regulatory protein	Homo sapiens	111-115
11404395-4	2001	The JBT3002-induced production of nitric oxide and TNF-alpha was significantly inhibited by tricyclodecan-9-yl xanthogenate (D609), a selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (PC-PLC).	Phosphatidylcholines	157-176	tumor necrosis factor	Mus musculus	51-60
11279152-4	2001	Mixing StAR with dansyl-labeled vesicles composed of phosphatidylcholine increased the fluorescence intensity of dansyl emission excited at 280 nm by 10-40%.	Phosphatidylcholines	53-72	steroidogenic acute regulatory protein	Homo sapiens	7-11
11369799-3	2001	Here we applied proton NMR spectroscopy to probe surface phospholipids phosphatidylcholine (PC) and sphingomyelin (SM) of LDL particles during proteolytic degradation of apolipoprotein B-100 (apoB-100).	Phosphatidylcholines	71-90	apolipoprotein B	Homo sapiens	170-190
11369799-3	2001	Here we applied proton NMR spectroscopy to probe surface phospholipids phosphatidylcholine (PC) and sphingomyelin (SM) of LDL particles during proteolytic degradation of apolipoprotein B-100 (apoB-100).	Phosphatidylcholines	92-94	apolipoprotein B	Homo sapiens	170-190
11369799-4	2001	Initiation of apoB-100 degradation was accompanied by the abruptly increased intensity of the choline -N(CH(3))(3) resonance of PC molecules, indicating disruption of their interactions with apoB-100.	Phosphatidylcholines	128-130	apolipoprotein B	Homo sapiens	14-22
11409160-2	2001	We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	54-73	phospholipase A2 group IB	Homo sapiens	26-30
11358821-4	2001	Addition of 0.1-10 microM doxorubicin to these cells led to a concentration- and time-dependent inhibition of total iPLA(2), as measured using (16:0, [(3)H]18:1) plasmenylcholine and phosphatidylcholine substrates in the presence or absence of calcium.	Phosphatidylcholines	183-202	phospholipase A2 group VI	Rattus norvegicus	116-123
11432454-1	2001	Phospholipase A2, which is linked to a protein kinase C pathway, hydrolyzes phosphatidylcholine into cis-unsaturated free fatty acids and lysophosphatidylcholine (lysoPC).	Phosphatidylcholines	76-95	phospholipase A2 group IB	Rattus norvegicus	0-16
11313316-2	2001	MDR3 is the phosphatidylcholine translocator across the hepatocyte canalicular membrane.	Phosphatidylcholines	12-31	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
11350180-9	2001	Analysis of urinary sulfatides in arylsulfatase A pseudodeficiency patients showed a mild elevation in some individuals when related to urinary phosphatidylcholine.	Phosphatidylcholines	144-163	arylsulfatase A	Homo sapiens	34-49
11342631-4	2001	A murine monoclonal anti-prothrombin Ab and three of three LA IgGs enhanced prothrombin binding to 75:25 phosphatidyl choline:phosphatidyl serine vesicles measured by either ultracentrifugation or right-angle light scattering.	Phosphatidylcholines	105-125	coagulation factor II, thrombin	Homo sapiens	25-36
11342631-4	2001	A murine monoclonal anti-prothrombin Ab and three of three LA IgGs enhanced prothrombin binding to 75:25 phosphatidyl choline:phosphatidyl serine vesicles measured by either ultracentrifugation or right-angle light scattering.	Phosphatidylcholines	105-125	coagulation factor II, thrombin	Homo sapiens	76-87
11409160-2	2001	We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	54-73	proprotein convertase subtilisin/kexin type 7	Homo sapiens	82-111
11409160-2	2001	We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	75-77	phospholipase A2 group IB	Homo sapiens	26-30
11409160-2	2001	We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resulting in increased bacterial translocation (BT) and decreased transepithelial electrical resistance (TEER).	Phosphatidylcholines	75-77	proprotein convertase subtilisin/kexin type 7	Homo sapiens	82-111
11409160-5	2001	PLA2 may also mediate the hydrolysis of luminal phospholipids other than PC.	Phosphatidylcholines	73-75	phospholipase A2 group IB	Homo sapiens	0-4
11368160-0	2001	Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	307-326	fibroblast growth factor 2	Mus musculus	22-52
11278673-2	2001	Many potential iPLA(2)beta functions have been proposed, including a signaling role in beta-cell insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid incorporation into P388D1 cell phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase A2, group VI	Mus musculus	15-26
11278673-2	2001	Many potential iPLA(2)beta functions have been proposed, including a signaling role in beta-cell insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid incorporation into P388D1 cell phosphatidylcholine (PC).	Phosphatidylcholines	247-249	phospholipase A2, group VI	Mus musculus	15-26
11368160-0	2001	Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	307-326	fibroblast growth factor 2	Mus musculus	168-198
11368160-0	2001	Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. In a previous study we showed that basic fibroblast growth factor (bFGF) stimulates activation of protein kinase C through phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	307-326	fibroblast growth factor 2	Mus musculus	200-204
11294911-0	2001	Evidence for an intrinsic toxicity of phosphatidylcholine to Sec14p-dependent protein transport from the yeast Golgi complex.	Phosphatidylcholines	38-57	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	61-67
11254505-7	2001	Exogenous EGF significantly increased surface hydrophobicity and phosphatidylcholine concentration in the mucus layer.	Phosphatidylcholines	65-84	epidermal growth factor like 1	Rattus norvegicus	10-13
11290831-5	2001	We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation.	Phosphatidylcholines	35-54	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
11290831-5	2001	We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation.	Phosphatidylcholines	35-54	C-C motif chemokine ligand 4	Rattus norvegicus	149-153
11290831-5	2001	We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation.	Phosphatidylcholines	35-54	platelet activating factor receptor	Homo sapiens	241-282
11294898-1	2001	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11294898-1	2001	Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid.	Phosphatidylcholines	33-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11290831-5	2001	We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation.	Phosphatidylcholines	35-55	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
11290831-5	2001	We found that oxidatively modified phosphatidylcholines were present in the livers of CCl4-exposed rats and not in livers from control animals, that CCl4 metabolism generated lipids that activated 293 cells stably transfected with the human platelet-activating factor (PAF) receptor, and that this PAF-like activity was formed as rapidly as isoprostane-containing phosphatidylcholine (iPC) during oxidation.	Phosphatidylcholines	35-55	platelet activating factor receptor	Homo sapiens	241-282
11283284-1	2001	The phosphatidylcholine-specific phospholipase D1 (PLD1) in Saccharomyces cerevisiae is involved in vesicle transport and is essential for sporulation.	Phosphatidylcholines	4-23	phospholipase D	Saccharomyces cerevisiae S288C	51-55
11285138-3	2001	Some fluorescent PC was transported in vesicles to a subapical compartment (SAC) or apical recycling compartment (ARC) in polarized HepG2 cells as shown by colocalization with fluorescent sphingomyelin (C6-NBD-SM) and fluorescent transferrin, respectively.	Phosphatidylcholines	17-19	transferrin	Homo sapiens	230-241
11084049-1	2001	In mammalian cells, phosphatidylserine is synthesized by two different enzymes, phosphatidylserine synthase (PSS)-1 and -2, via a base exchange reaction in which the head group of a phospholipid (phosphatidylcholine or phosphatidylethanolamine) is replaced by l-serine.	Phosphatidylcholines	196-215	phosphatidylserine synthase 1	Homo sapiens	80-122
11106649-4	2001	Heparin nonbinding sPLA(2)-X liberates arachidonic acid most likely from the phosphatidylcholine-rich outer plasma membrane in a glypican-independent manner.	Phosphatidylcholines	77-96	phospholipase A2, group X	Rattus norvegicus	19-28
11106649-5	2001	In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor.	Phosphatidylcholines	130-149	RB transcriptional corepressor like 2	Rattus norvegicus	19-24
11106649-5	2001	In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor.	Phosphatidylcholines	130-149	glypican 1	Homo sapiens	43-51
11106649-5	2001	In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor.	Phosphatidylcholines	130-149	phospholipase A2 group IIA	Rattus norvegicus	53-69
11223016-2	2001	CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns.	Phosphatidylcholines	69-75	cut like homeobox 1	Homo sapiens	0-3
11243703-1	2001	From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells.	Phosphatidylcholines	206-225	tumor necrosis factor	Mus musculus	28-37
11243703-1	2001	From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells.	Phosphatidylcholines	206-225	tumor necrosis factor	Mus musculus	285-294
11243703-1	2001	From the hypothesis that in TNF-alpha-resistant cells the activity of mitochondrial phospholipase A2 could be reversed by a lysophospholipid acyltransferase, we report that the mitochondrial reacylation of phosphatidylcholine as phosphatidylethanolamine was considerably higher in C6 (TNF-alpha-resistant) than in WEHI-164 (TNF-alpha-sensitive) cells.	Phosphatidylcholines	206-225	tumor necrosis factor	Mus musculus	285-294
11223016-2	2001	CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns.	Phosphatidylcholines	120-126	cut like homeobox 1	Homo sapiens	0-3
11282754-2	2001	In these cells, GLP-1(7-36) amide and exendin-4 stimulated phosphatidylcholine secretion (PC) and cAMP formation in a concentration-dependent manner; these effects were reversed by exendin(9-39).	Phosphatidylcholines	59-78	glucagon like peptide 1 receptor	Homo sapiens	16-21
11251067-0	2001	Phosphatidylcholine synthesis influences the diacylglycerol homeostasis required for SEC14p-dependent Golgi function and cell growth.	Phosphatidylcholines	0-19	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	85-91
11248688-10	2001	TMR transport by Pgp reconstituted into proteoliposomes composed of two synthetic phosphatidylcholines showed a highly unusual biphasic temperature dependence.	Phosphatidylcholines	82-102	phosphoglycolate phosphatase	Homo sapiens	17-20
11251067-2	2001	In yeast, diacylglycerol accepts a phosphocholine moiety through a CPT1-derived cholinephosphotransferase activity to directly synthesize phosphatidylcholine.	Phosphatidylcholines	138-157	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	67-71
11251067-4	2001	In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	167-186	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	29-33
11251067-4	2001	In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	167-186	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	39-43
11251067-4	2001	In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	167-186	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	133-137
11251067-5	2001	Alterations in the level of diacylglycerol consumption through alterations in phosphatidylcholine synthesis directly correlated with the level of SEC14-dependent invertase secretion and affected cell viability.	Phosphatidylcholines	78-97	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	146-151
11239826-6	2001	The acyl composition of the PA generated by wounding suggests that the major in vivo substrate of PLD in wild-type leaves was PC, and that PG hydrolysis accounted for 10-15% of the wound-induced PA in wild-type leaves.	Phosphatidylcholines	126-128	phospholipase D alpha 1	Arabidopsis thaliana	98-101
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	30-49	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	218-222
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	160-179	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	199-203
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	30-49	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	199-203
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	160-179	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	213-217
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	30-49	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	204-208
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	160-179	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	218-222
11078727-4	2001	In contrast, the induction of phosphatidylcholine deacylation does occur in a strain bearing mutations in genes encoding enzymes of the methylation pathway for phosphatidylcholine biosynthesis (i.e. CHO2/PEM1 and OPI3/PEM2).	Phosphatidylcholines	30-49	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	213-217
11341959-5	2001	In accordance with its higher hydrolyzing activity toward phosphatidylcholine, mouse sPLA(2)-X induced a potent production of lysophosphatidylcholine.	Phosphatidylcholines	58-77	phospholipase A2, group X	Mus musculus	85-94
11159007-9	2001	IA endotoxin caused rapid and sustained increases in SP mRNAs that preceded the increase in alveolar saturated phosphatidylcholine processing of SP-B and improved lung compliance in prematurely delivered lambs.	Phosphatidylcholines	111-130	pulmonary surfactant-associated protein B	Ovis aries	145-149
11172815-4	2001	In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist.	Phosphatidylcholines	212-231	ADP ribosylation factor GTPase activating protein 3	Homo sapiens	43-50
11172815-4	2001	In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist.	Phosphatidylcholines	212-231	ADP ribosylation factor GTPase activating protein 3	Homo sapiens	115-122
11159449-0	2001	Dynamics of membrane penetration of the fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) group attached to an acyl chain of phosphatidylcholine.	Phosphatidylcholines	127-146	OXA1L mitochondrial inner membrane protein	Homo sapiens	66-71
11133741-4	2001	Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC).	Phosphatidylcholines	90-109	tumor necrosis factor	Homo sapiens	18-26
11314866-4	2001	Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine.	Phosphatidylcholines	134-153	annexin A5	Homo sapiens	11-20
11314866-4	2001	Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine.	Phosphatidylcholines	134-153	annexin A5	Homo sapiens	86-95
11314866-4	2001	Binding of annexin V to anionic phospholipid is Ca(+2)-dependent and, in its absence, annexin V was found to bind most avidly to 100% phosphatidylcholine in a saturable manner, followed by decreasing percentages of phosphatidylcholine.	Phosphatidylcholines	215-234	annexin A5	Homo sapiens	11-20
11133741-4	2001	Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC).	Phosphatidylcholines	90-109	C-C motif chemokine ligand 2	Homo sapiens	35-40
21331729-1	2001	Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2).	Phosphatidylcholines	65-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11347966-2	2001	Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids.	Phosphatidylcholines	28-47	phospholipase A2 group VII	Homo sapiens	77-84
11347966-2	2001	Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids.	Phosphatidylcholines	49-51	phospholipase A2 group VII	Homo sapiens	77-84
11123317-6	2001	Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5.	Phosphatidylcholines	98-117	CD5 molecule	Homo sapiens	85-88
11123317-6	2001	Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5.	Phosphatidylcholines	98-117	CD5 molecule	Homo sapiens	234-237
11734063-1	2001	BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh).	Phosphatidylcholines	54-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
11734063-1	2001	BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh).	Phosphatidylcholines	75-77	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
11329616-5	2001	Western blot analysis showed a significant increase in I- and L-FABP expression following an 8-hour incubation period with butyric acid, oleic acid, and phosphatidylcholine.	Phosphatidylcholines	153-172	fatty acid binding protein 1	Homo sapiens	62-68
11136854-4	2001	In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation.	Phosphatidylcholines	90-109	Phospholipase C at 21C	Drosophila melanogaster	115-118
11136854-4	2001	In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation.	Phosphatidylcholines	90-109	transient receptor potential-like	Drosophila melanogaster	150-154
11136854-4	2001	In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation.	Phosphatidylcholines	111-113	Phospholipase C at 21C	Drosophila melanogaster	115-118
11136854-4	2001	In fura-2 assays, extracellular application of bacterial phosphatidylinositol (PI)-PLC or phosphatidylcholine (PC)-PLC caused a transient increase in TrpL channel activity, the magnitude of which was significantly less than that observed following receptor stimulation.	Phosphatidylcholines	111-113	transient receptor potential-like	Drosophila melanogaster	150-154
11269664-0	2001	Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity.	Phosphatidylcholines	30-49	cut-like homeobox 1	Rattus norvegicus	54-57
11269664-1	2001	We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline.	Phosphatidylcholines	105-124	cut-like homeobox 1	Rattus norvegicus	134-137
11269664-1	2001	We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline.	Phosphatidylcholines	126-128	cut-like homeobox 1	Rattus norvegicus	134-137
21331729-1	2001	Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2).	Phosphatidylcholines	65-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11147995-1	2000	Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion.	Phosphatidylcholines	133-152	ATP binding cassette subfamily B member 4	Homo sapiens	101-105
11147995-1	2000	Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion.	Phosphatidylcholines	133-152	ATP binding cassette subfamily B member 1	Homo sapiens	106-120
11147995-1	2000	Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion.	Phosphatidylcholines	154-156	ATP binding cassette subfamily B member 4	Homo sapiens	101-105
11147995-1	2000	Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion.	Phosphatidylcholines	154-156	ATP binding cassette subfamily B member 1	Homo sapiens	106-120
11090971-1	2000	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11007780-6	2000	Results obtained with phagocyte membrane vesicles can be reproduced fully by replacing these with partially purified cytochrome b(559), incorporated in phosphatidylcholine vesicles.	Phosphatidylcholines	152-171	mitochondrially encoded cytochrome b	Homo sapiens	117-129
11007780-7	2000	Prenylated, but not nonprenylated, Rac1 binds spontaneously to phagocyte membrane vesicles and also to artificial, protein-free, phosphatidylcholine vesicles, a process counteracted by GDP dissociation inhibitor for Rho.	Phosphatidylcholines	129-148	Rac family small GTPase 1	Homo sapiens	35-39
11007780-9	2000	Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1.	Phosphatidylcholines	135-154	inhibitor of growth family member 1	Homo sapiens	15-18
11007780-9	2000	Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1.	Phosphatidylcholines	135-154	Rac family small GTPase 1	Homo sapiens	76-80
11007780-9	2000	Amphiphile and p47(phox)-independent NADPH oxidase activation by prenylated Rac1 is inhibited by Rho GDP dissociation inhibitor and by phosphatidylcholine vesicles, both competing with membrane for prenylated Rac1.	Phosphatidylcholines	135-154	Rac family small GTPase 1	Homo sapiens	209-213
11090971-1	2000	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11090971-1	2000	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline.	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11090971-1	2000	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline.	Phosphatidylcholines	71-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11192332-5	2000	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction.	Phosphatidylcholines	102-121	phosphatidylethanolamine N-methyltransferase	Homo sapiens	11-53
11112525-2	2000	To probe mechanisms for membrane interactions and phosphatidylcholine binding, we expressed recombinant human PC-TP in Escherichia coli using a synthetic gene.	Phosphatidylcholines	50-69	phosphatidylcholine transfer protein	Homo sapiens	110-115
11112525-10	2000	These studies suggest that tandem alpha-helices located near the C-terminus of PC-TP facilitate membrane binding and extraction of phosphatidylcholines.	Phosphatidylcholines	131-151	phosphatidylcholine transfer protein	Homo sapiens	79-84
11111093-2	2000	LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins.	Phosphatidylcholines	55-75	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
11112443-6	2000	Finally, recombinant expression of hGIIF sPLA(2) in Escherichia coli shows that the enzyme is Ca(2+)-dependent, maximally active at pH 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.	Phosphatidylcholines	183-202	phospholipase A2 group IIA	Homo sapiens	41-48
11152958-4	2000	When phosphatidylcholine-specific phospholipase C (PC-PLC) was inhibited by D609, the Fas-induced changes in PLD activity, DAG content, and PKC translocation were inhibited.	Phosphatidylcholines	5-24	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-112
11152958-4	2000	When phosphatidylcholine-specific phospholipase C (PC-PLC) was inhibited by D609, the Fas-induced changes in PLD activity, DAG content, and PKC translocation were inhibited.	Phosphatidylcholines	5-24	protein kinase C beta	Homo sapiens	140-143
11112525-1	2000	Phosphatidylcholine transfer protein (PC-TP) is a 214-amino acid cytosolic protein that promotes intermembrane transfer of phosphatidylcholines, but no other phospholipid class.	Phosphatidylcholines	123-143	phosphatidylcholine transfer protein	Homo sapiens	0-36
11112525-1	2000	Phosphatidylcholine transfer protein (PC-TP) is a 214-amino acid cytosolic protein that promotes intermembrane transfer of phosphatidylcholines, but no other phospholipid class.	Phosphatidylcholines	123-143	phosphatidylcholine transfer protein	Homo sapiens	38-43
11106499-2	2000	Our earlier studies demonstrated that high-density lipoproteins (HDLs) stimulate multiple signaling pathways, including activation of phosphatidylcholine-specific phospholipases C and D (PC-PLs) and phosphatidylinositol-specific phospholipase C (PI-PLC).	Phosphatidylcholines	134-153	phospholipase C beta 1	Homo sapiens	246-252
11106499-15	2000	Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation.	Phosphatidylcholines	19-38	apolipoprotein A1	Homo sapiens	0-5
11192332-5	2000	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction.	Phosphatidylcholines	102-121	phosphatidylethanolamine N-methyltransferase	Homo sapiens	55-59
11192332-5	2000	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction.	Phosphatidylcholines	123-125	phosphatidylethanolamine N-methyltransferase	Homo sapiens	11-53
11192332-5	2000	Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction.	Phosphatidylcholines	123-125	phosphatidylethanolamine N-methyltransferase	Homo sapiens	55-59
11108734-7	2000	In HepG2 cells, the expression of the human SR-BI homolog was reduced when the vitE content was increased by incubating the cells with vitE-loaded HDL or with phosphatidylcholine/vitE vesicles.	Phosphatidylcholines	159-178	scavenger receptor class B member 1	Homo sapiens	44-49
11080206-10	2000	These data suggest multiple beneficial effects of CDP-choline: (1) stabilizing the cell membrane by restoring PtdCho and sphingomyelin (prominent components of outer cell membrane), (2) attenuating the release of ArAc and limiting its oxidative metabolism, and (3) restoring cardiolipin levels.	Phosphatidylcholines	110-116	cut like homeobox 1	Homo sapiens	50-53
11108844-0	2000	Cholecystokinin octapeptide CCK-8 and carbachol reduce [(32)P]orthophosphate labeling of phosphatidylcholine without modifying phospholipase D activity in rat pancreatic acini.	Phosphatidylcholines	89-108	cholecystokinin	Rattus norvegicus	0-15
11108844-3	2000	However, the secretagogues cholecystokinin octapeptide and carbachol did not enhance basal accumulation of (32)P-phosphatidylalcohol, yet they decreased [(32)P]phosphatidylcholine content and stimulated the generation of [(32)P]phosphatidic acid.	Phosphatidylcholines	160-179	cholecystokinin	Rattus norvegicus	27-42
11108736-2	2000	Lecithin:retinol acyltransferase (LRAT), present in microsomes, catalyzes the transfer of the sn-1 fatty acid of phosphatidylcholine to retinol bound to a cellular retinol-binding protein.	Phosphatidylcholines	113-132	lecithin retinol acyltransferase	Rattus norvegicus	0-32
11108736-2	2000	Lecithin:retinol acyltransferase (LRAT), present in microsomes, catalyzes the transfer of the sn-1 fatty acid of phosphatidylcholine to retinol bound to a cellular retinol-binding protein.	Phosphatidylcholines	113-132	lecithin retinol acyltransferase	Rattus norvegicus	34-38
11115895-1	2000	Saccharomyces cerevisiae opi3 mutant strains do not have the phospholipid N-methyltransferase that catalyzes the two terminal methylations in the phosphatidylcholine (PC) biosynthetic pathway.	Phosphatidylcholines	146-165	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	25-29
11101661-7	2000	Unexpectedly, PC-PLC inhibited HBL lysis of sheep erythrocytes (&lt;2% PC) and enhanced the discontinuous haemolysis pattern that is characteristic of HBL in sheep blood agar.	Phosphatidylcholines	14-16	heparan sulfate proteoglycan 2	Homo sapiens	17-20
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Phosphatidylcholines	59-78	interleukin 1 beta	Homo sapiens	132-140
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Phosphatidylcholines	59-78	intercellular adhesion molecule 1	Homo sapiens	149-155
11093788-12	2000	Taken together, IL-1beta activates phosphatidylcholine-specific phospholipase C and induces activation of PKCalpha and protein tyrosine kinase, resulting in the stimulation of NIK, IKK2, and NF-kappaB in the ICAM-1 promoter, then initiation of ICAM-1 expression.	Phosphatidylcholines	35-54	interleukin 1 beta	Homo sapiens	16-24
11115895-1	2000	Saccharomyces cerevisiae opi3 mutant strains do not have the phospholipid N-methyltransferase that catalyzes the two terminal methylations in the phosphatidylcholine (PC) biosynthetic pathway.	Phosphatidylcholines	167-169	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	25-29
11082530-7	2000	A new molecular interaction model for the beta-sheet structure and phosphatidylcholine headgroups is introduced and an overall view of the tertiary structure of apolipoprotein B-100 in the LDL particles is presented.	Phosphatidylcholines	67-86	apolipoprotein B	Homo sapiens	161-181
10944538-4	2000	Previous work by us showed that at early stages of FC loading, when macrophages are still healthy, there is activation of the phosphatidylcholine (PC) biosynthetic enzyme, CTP:phosphocholine cytidylyltransferase (CT), and accumulation of PC mass.	Phosphatidylcholines	126-145	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	172-211
10903316-8	2000	Consistently, in vitro biomolecular interaction between PS/phosphatidylethanolamine /phosphatidylcholine liposomes, and Raf-1 increased in a PS concentration-dependent manner.	Phosphatidylcholines	85-104	v-raf-leukemia viral oncogene 1	Mus musculus	120-125
10938271-3	2000	Taking advantage of the substrate specificity of PSS1, we showed that (i) MAM contain choline exchange activity, whereas this activity is very low in the bulk of the ER, (ii) serine exchange activity is inhibited by choline to a much greater extent in MAM than in ER, and (iii) MAM use phosphatidylcholine and phosphatidylethanolamine as substrates for phosphatidylserine biosynthesis, whereas the ER utilizes only phosphatidylethanolamine.	Phosphatidylcholines	286-305	phosphatidylserine synthase 1	Cricetulus griseus	49-53
11023832-2	2000	The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha.	Phosphatidylcholines	85-104	CD34 molecule	Homo sapiens	188-192
11099795-4	2000	Colipase, a surface-active cofactor of lipase, relieves inhibition by phosphatidylcholine in several ways.	Phosphatidylcholines	70-89	colipase	Homo sapiens	0-45
11052674-3	2000	Phospholipid vesicles composed of PE, phosphatidylserine (PS), and phosphatidylcholine support factor Xa generation.	Phosphatidylcholines	67-86	coagulation factor X	Homo sapiens	95-104
11053135-0	2000	PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study.	Phosphatidylcholines	106-125	proteolipid ATPase	Saccharomyces cerevisiae S288C	0-4
11060354-7	2000	We also demonstrated that organic cation transport by mOct1/Slc22a1 is inhibited by several organic cations, and that the gene is expressed in the perinatal period, at a time when phosphatidylcholine synthesis increases.	Phosphatidylcholines	180-199	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	54-59
11060354-7	2000	We also demonstrated that organic cation transport by mOct1/Slc22a1 is inhibited by several organic cations, and that the gene is expressed in the perinatal period, at a time when phosphatidylcholine synthesis increases.	Phosphatidylcholines	180-199	solute carrier family 22 member 1	Homo sapiens	60-67
11053518-1	2000	An aqueous extract of Platycodi radix inhibited the hydrolysis of triolein emulsified with phosphatidylcholine by pancreatic lipase in vitro and it reduced the elevation of rat plasma triacylglycerol level 2-4 h after oral administration of a lipid emulsion containing corn oil.	Phosphatidylcholines	91-110	lipase G, endothelial type	Rattus norvegicus	125-131
11080676-3	2000	gVPLA(2) is homologous to other group II PLA(2) family members but has distinctive enzymatic properties, including its activity to effectively hydrolyze phosphatidylcholine (PC) vesicles and the outer plasma membrane of mammalian cells.	Phosphatidylcholines	153-172	phospholipase A2 group V	Homo sapiens	0-8
11080676-3	2000	gVPLA(2) is homologous to other group II PLA(2) family members but has distinctive enzymatic properties, including its activity to effectively hydrolyze phosphatidylcholine (PC) vesicles and the outer plasma membrane of mammalian cells.	Phosphatidylcholines	153-172	phospholipase A2 group IB	Homo sapiens	2-8
11080676-4	2000	Mutational studies showed that gVPLA(2) has a unique structure that allows effective binding to PC membranes and efficient catalysis of an active-site-bound PC substrate.	Phosphatidylcholines	96-98	phospholipase A2 group V	Homo sapiens	31-39
11080676-4	2000	Mutational studies showed that gVPLA(2) has a unique structure that allows effective binding to PC membranes and efficient catalysis of an active-site-bound PC substrate.	Phosphatidylcholines	157-159	phospholipase A2 group V	Homo sapiens	31-39
11023832-2	2000	The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha.	Phosphatidylcholines	85-104	CD38 molecule	Homo sapiens	196-200
11023832-2	2000	The present study was aimed at evaluating the respective role of two phospholipases, phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) in the response of the CD34(+) CD38(-) KG1a cells to TNFalpha.	Phosphatidylcholines	85-104	tumor necrosis factor	Homo sapiens	218-226
11129952-6	2000	The mechanism for the reduction in radiolabelled fatty acid incorporation into phosphatidylcholine was a 64% (p &lt; 0.05) reduction in membrane phospholipase A2 activity.	Phosphatidylcholines	79-98	phospholipase A2 group IB	Homo sapiens	145-161
11009606-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	119-138	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
11009606-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	140-142	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-35
11009606-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	140-142	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
11009606-3	2000	Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients.	Phosphatidylcholines	131-133	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	29-32
11009606-3	2000	Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients.	Phosphatidylcholines	131-133	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	34-47
11012677-4	2000	Our differential scanning calorimetry results reveal that P17 slightly perturbs the phase behaviour of neutral phosphatidylcholine and negatively charged multilamellar vesicles.	Phosphatidylcholines	111-130	assembly	Enterobacteria phage PRD1	58-61
11015229-2	2000	Comparison of the positional dependences of the spectral data for the two series of spin-labeled lipids suggests that the N-acyl chain is positioned at approximately the same level as the sn-2 chain of the phosphatidylcholine spin-label.	Phosphatidylcholines	206-225	spindlin 1	Homo sapiens	84-88
11015229-2	2000	Comparison of the positional dependences of the spectral data for the two series of spin-labeled lipids suggests that the N-acyl chain is positioned at approximately the same level as the sn-2 chain of the phosphatidylcholine spin-label.	Phosphatidylcholines	206-225	spindlin 1	Homo sapiens	226-230
11015229-3	2000	Further, similar conclusions are reached when the ESR spectra of the N-acyl PE spin-labels in dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylethanolamine (DMPE) host matrixes are compared with those of phosphatidylcholine spin-labels in these two lipids.	Phosphatidylcholines	105-124	spindlin 1	Homo sapiens	79-83
11009606-0	2000	(R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain.	Phosphatidylcholines	47-66	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-35
11009606-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme that has a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	119-138	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-35
11000525-2	2000	To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned.	Phosphatidylcholines	32-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64
10889195-4	2000	The bovine LDL receptor has been purified and reconstituted into egg yolk phosphatidylcholine vesicle bilayers.	Phosphatidylcholines	74-93	low density lipoprotein receptor	Bos taurus	11-23
11000525-2	2000	To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned.	Phosphatidylcholines	32-51	phospholipase D1	Homo sapiens	86-91
11018472-1	2000	Our previous studies have shown that parathyroid hormone (PTH) stimulates phosphatidylcholine (PC) hydrolysis by phospholipase D (PLD) and transphosphatidylation in UMR-106 osteoblastic cells.	Phosphatidylcholines	95-97	parathyroid hormone	Rattus norvegicus	37-56
11000525-2	2000	To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned.	Phosphatidylcholines	32-51	phospholipase D2	Homo sapiens	96-101
10893425-1	2000	A cholinephosphotransferase activity catalyzes the final step in the de novo synthesis of phosphatidylcholine via the transfer of a phosphocholine moiety from CDP choline to diacylglycerol.	Phosphatidylcholines	90-109	cut like homeobox 1	Homo sapiens	159-162
11018469-0	2000	Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis.	Phosphatidylcholines	208-227	receptor for activated C kinase 1	Mus musculus	35-66
11018469-0	2000	Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis.	Phosphatidylcholines	208-227	receptor for activated C kinase 1	Mus musculus	68-73
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Phosphatidylcholines	52-71	Phospholipase D	Drosophila melanogaster	107-110
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Phosphatidylcholines	73-79	Phospholipase D	Drosophila melanogaster	107-110
10889208-2	2000	We have investigated the basis for the protein substrate specificity of Xase using TF reconstituted into vesicles of phosphatidylcholine, phosphatidylserine, or pure phosphatidylcholine.	Phosphatidylcholines	117-136	coagulation factor III, tissue factor	Homo sapiens	83-85
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Phosphatidylcholines	73-79	Phospholipase D	Drosophila melanogaster	217-220
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Phosphatidylcholines	73-79	Receptor of activated protein kinase C 1	Drosophila melanogaster	318-323
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Phosphatidylcholines	293-299	Phospholipase D	Drosophila melanogaster	44-47
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Phosphatidylcholines	293-299	Receptor of activated protein kinase C 1	Drosophila melanogaster	124-129
11018472-1	2000	Our previous studies have shown that parathyroid hormone (PTH) stimulates phosphatidylcholine (PC) hydrolysis by phospholipase D (PLD) and transphosphatidylation in UMR-106 osteoblastic cells.	Phosphatidylcholines	74-93	parathyroid hormone	Rattus norvegicus	37-56
11045596-7	2000	However, the phosphatidylcholine (PC)-specific phospholipase C (PLC) inhibitor D609 decreased the KCN-induced IL-1alpha mRNA and protein in PC12 cells suggests that PC-PLC might play a role in cytokine induction during hypoxia.	Phosphatidylcholines	13-32	interleukin 1 alpha	Rattus norvegicus	110-119
11045596-7	2000	However, the phosphatidylcholine (PC)-specific phospholipase C (PLC) inhibitor D609 decreased the KCN-induced IL-1alpha mRNA and protein in PC12 cells suggests that PC-PLC might play a role in cytokine induction during hypoxia.	Phosphatidylcholines	34-36	interleukin 1 alpha	Rattus norvegicus	110-119
11033981-6	2000	RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine.	Phosphatidylcholines	137-156	pancreatic lipase	Mus musculus	60-77
10973618-0	2000	Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes.	Phosphatidylcholines	25-44	adrenomedullin	Rattus norvegicus	0-14
10973618-4	2000	Adrenomedullin increased the secretion of phosphatidylcholine, the predominant component of pulmonary surfactant, by type II pneumocytes.	Phosphatidylcholines	42-61	adrenomedullin	Rattus norvegicus	0-14
10964416-6	2000	Catalytically, DAGK showed a strong preference for bicelles containing 3-(cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate (CHAPSO) as the detergentcomponent relative to short-chained phosphatidylcholine.DAGK also exhibited a preference for dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine bicelles relative to those of dilauroylphosphatidylcholine.	Phosphatidylcholines	196-215	diacylglycerol kinase alpha	Homo sapiens	15-19
10973866-15	2000	01) between plasma PLTP and plasma phosphatidylcholine transfer activity (range, 3.5-10.5 micromol.	Phosphatidylcholines	35-54	phospholipid transfer protein	Homo sapiens	19-23
10973058-1	2000	Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5"-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT).	Phosphatidylcholines	0-19	CCT	Homo sapiens	146-149
10973058-1	2000	Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5"-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT).	Phosphatidylcholines	21-23	CCT	Homo sapiens	146-149
10973058-3	2000	The membrane-binding domain of CCT is a long amphipathic alpha helix that responds to changes in the physical properties of PC-deficient membranes.	Phosphatidylcholines	124-126	CCT	Homo sapiens	31-34
10956052-0	2000	Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol.	Phosphatidylcholines	71-90	apolipoprotein A1	Homo sapiens	52-70
10956052-0	2000	Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol.	Phosphatidylcholines	190-209	apolipoprotein A1	Homo sapiens	52-70
10956053-4	2000	Formation of the complex between G(t) and photoactivated rhodopsin reconstituted into phosphatidylcholine vesicles caused prominent infrared absorption increases at 1641, 1550, and 1517 cm(-)(1).	Phosphatidylcholines	86-105	rhodopsin	Homo sapiens	57-66
10956052-5	2000	In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC).	Phosphatidylcholines	153-172	apolipoprotein A1	Homo sapiens	110-128
10956052-5	2000	In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC).	Phosphatidylcholines	153-172	apolipoprotein A1	Homo sapiens	130-136
10956052-5	2000	In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC).	Phosphatidylcholines	174-176	apolipoprotein A1	Homo sapiens	110-128
10956052-5	2000	In this paper, we show that ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I (apoA-I) complexed with phosphatidylcholine (PC).	Phosphatidylcholines	174-176	apolipoprotein A1	Homo sapiens	130-136
10956052-6	2000	Ethanol significantly inhibited binding of PC to apoA-I, inhibited incorporation of cholesterol only when apoA-I contained PC, and did not alter incorporation of cholesterol into HDL.	Phosphatidylcholines	43-45	apolipoprotein A1	Homo sapiens	49-55
10956052-6	2000	Ethanol significantly inhibited binding of PC to apoA-I, inhibited incorporation of cholesterol only when apoA-I contained PC, and did not alter incorporation of cholesterol into HDL.	Phosphatidylcholines	123-125	apolipoprotein A1	Homo sapiens	106-112
10852916-11	2000	PLD2 regulates the breakdown of phosphatidylcholine and has been implicated in vesicular trafficking.	Phosphatidylcholines	32-51	phospholipase D2	Homo sapiens	0-4
10843997-2	2000	Transient expression of ARF-1(T31N), a GDP-restrictive mutant, significantly inhibited apolipoprotein B-100 (apoB-100) VLDL production without influencing the biosynthesis of apoB-100 low density lipoproteins or total apoB production (indicating that it inhibited the second step of VLDL assembly) and without altering total protein production or biosynthesis of transferrin, phosphatidylcholine, or triglycerides.	Phosphatidylcholines	376-395	ADP-ribosylation factor 1	Rattus norvegicus	24-29
11004609-0	2000	Arachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytes.	Phosphatidylcholines	28-47	interleukin 2	Rattus norvegicus	96-109
11004609-0	2000	Arachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytes.	Phosphatidylcholines	28-47	interferon gamma	Rattus norvegicus	114-130
10918072-2	2000	The MDR3 P-glycoprotein is a transmembrane protein that translocates phosphatidylcholine.	Phosphatidylcholines	69-88	ATP binding cassette subfamily B member 4	Homo sapiens	4-8
10933785-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	115-134	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
10933785-1	2000	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	136-138	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
10827200-7	2000	Analysis of molecular species of microsomal phosphatidylcholine and phosphatidylethanolamine by electron spray tandem mass spectrometry revealed that the enrichment of oleoyl moieties was altered by the treatment of iPLA(2) antagonist.	Phosphatidylcholines	44-63	phospholipase A2 group VI	Rattus norvegicus	216-223
10918072-2	2000	The MDR3 P-glycoprotein is a transmembrane protein that translocates phosphatidylcholine.	Phosphatidylcholines	69-88	ATP binding cassette subfamily B member 1	Homo sapiens	9-23
10918072-8	2000	MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp.	Phosphatidylcholines	57-76	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
10918072-8	2000	MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp.	Phosphatidylcholines	57-76	ATP binding cassette subfamily B member 1	Homo sapiens	5-19
10918072-8	2000	MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp.	Phosphatidylcholines	57-76	ATP binding cassette subfamily B member 4	Homo sapiens	210-214
10918072-8	2000	MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp.	Phosphatidylcholines	57-76	phosphoglycolate phosphatase	Homo sapiens	215-219
10946014-1	2000	The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated.	Phosphatidylcholines	25-44	vascular cell adhesion molecule 1	Homo sapiens	100-133
10931974-2	2000	CAP18 intercalates into lipid matrices composed of LPS from sensitive strains, weaker into those made of LPS from a resistant strain (Proteus mirabilis strain R45) or negatively charged phospholipids, but not into those composed of neutral phosphatidylcholine.	Phosphatidylcholines	240-259	antimicrobial protein CAP18	Oryctolagus cuniculus	0-5
10946014-1	2000	The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated.	Phosphatidylcholines	25-44	vascular cell adhesion molecule 1	Homo sapiens	135-141
10946014-1	2000	The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated.	Phosphatidylcholines	46-48	vascular cell adhesion molecule 1	Homo sapiens	100-133
10946014-1	2000	The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated.	Phosphatidylcholines	46-48	vascular cell adhesion molecule 1	Homo sapiens	135-141
10921856-1	2000	We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques.	Phosphatidylcholines	170-189	tachykinin precursor 1	Homo sapiens	73-84
11055744-4	2000	The incubation of LA-N-1 nuclei with radioactive choline, phosphocholine or CDP-choline led to the production of labelled phosphatidylcholine.	Phosphatidylcholines	122-141	cut like homeobox 1	Homo sapiens	76-79
10972869-8	2000	Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate.	Phosphatidylcholines	149-168	patatin-like protein 2	Nicotiana tabacum	12-18
10972869-8	2000	Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate.	Phosphatidylcholines	149-168	patatin-like protein 3	Nicotiana tabacum	23-29
10972869-8	2000	Recombinant NtPat1 and NtPat3 enzymes were active in an assay using labelled bacterial membranes, and also displayed high bona fide PLA2 activity on phosphatidylcholine substrate.	Phosphatidylcholines	149-168	phospholipase A2 group IB	Homo sapiens	132-136
11040375-5	2000	Pyrene labeled phosphatidylcholine was added to 50 microg of cytosolic protein in Tris buffer (pH 8.0) containing fatty acid free-bovine serum albumin for a final assay volume of 2 ml.	Phosphatidylcholines	15-34	albumin	Mus musculus	137-150
10801835-3	2000	Phosphorylation of charge isomers of recombinant mouse PI-TPalpha confirmed that the PC-containing isomer was the better substrate.	Phosphatidylcholines	85-87	phosphatidylinositol transfer protein, alpha	Mus musculus	55-65
10801878-4	2000	270, 16277-16282) showed that expression of wild-type CT-alpha rescued the cells at 40 degrees C, whereas expression of phosphatidylethanolamine N-methyltransferase-2 (PEMT2) did not, even though PC levels appeared to be maintained at wild-type levels after 24 h at the restrictive temperature.	Phosphatidylcholines	196-198	choline-phosphate cytidylyltransferase A	Cricetulus griseus	54-62
10748000-8	2000	We conclude that GH rapidly increases the beta-cell cytoplasmic free [Ca(2+)] and also evokes a similar increase in DAG content via a phosphatidylcholine-specific phospholipase C, but does not affect mitogen-activated protein kinases, phospholipase D, or the cAMP signaling pathway.	Phosphatidylcholines	134-153	growth hormone 1	Homo sapiens	17-19
10921856-1	2000	We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques.	Phosphatidylcholines	191-193	tachykinin precursor 1	Homo sapiens	73-84
10941873-4	2000	L-FABP expression increased the masses of choline glycerophospholipids (ChoGpl) 1.5-fold, phosphatidylserine (PtdSer) 5.6-fold, ethanolamine glycerophospholipids 1.4-fold, sphingomyelin 1.7-fold, and phosphatidylinositol 2.6-fold.	Phosphatidylcholines	72-78	fatty acid binding protein 1	Homo sapiens	0-6
10918482-4	2000	Egg yolk phosphatidylcholine- and dipalmitoylphosphatidylcholine-based PCL were as effective as dioleoylphosphatidylethanolamine-based PCLs for gene transfer.	Phosphatidylcholines	9-28	polycystic kidney disease 2-like 1	Mus musculus	71-74
10933130-10	2000	Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates.	Phosphatidylcholines	54-73	surfactant protein C	Homo sapiens	75-80
10933130-10	2000	Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates.	Phosphatidylcholines	54-73	cytochrome c oxidase subunit 8A	Homo sapiens	135-139
10839997-2	2000	We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells.	Phosphatidylcholines	33-52	phospholipase A2 group V	Homo sapiens	15-23
10777500-9	2000	Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion.	Phosphatidylcholines	27-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-13
10777500-9	2000	Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion.	Phosphatidylcholines	48-50	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-13
10856718-1	2000	Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.	Phosphatidylcholines	126-145	ATP binding cassette subfamily B member 4	Homo sapiens	59-63
10856718-1	2000	Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.	Phosphatidylcholines	126-145	ATP binding cassette subfamily B member 4	Homo sapiens	65-69
10856718-1	2000	Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.	Phosphatidylcholines	126-145	ATP binding cassette subfamily B member 4	Homo sapiens	94-98
10856718-1	2000	Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.	Phosphatidylcholines	126-145	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	248-251
10873602-5	2000	Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM).	Phosphatidylcholines	69-88	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-42
10873602-5	2000	Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM).	Phosphatidylcholines	69-88	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
10839997-2	2000	We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells.	Phosphatidylcholines	33-52	phospholipase A2 group IIA	Homo sapiens	17-23
10839997-2	2000	We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells.	Phosphatidylcholines	77-96	phospholipase A2 group V	Homo sapiens	15-23
10860542-10	2000	The inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), D609 (100 microM), decreased fMLP-mediated AA release by approximately 35%.	Phosphatidylcholines	17-36	formyl peptide receptor 1	Homo sapiens	101-105
10839997-2	2000	We showed that hVPLA(2) can bind phosphatidylcholine membranes and hydrolyse phosphatidylcholine molecules much more efficiently than human group-IIa PLA(2), which accounts for its high activity on the outer plasma membrane of mammalian cells.	Phosphatidylcholines	77-96	phospholipase A2 group IIA	Homo sapiens	17-23
10839997-3	2000	To understand the molecular basis of the high phosphatidylcholine specificity of hVPLA(2), we mutated several residues (Gly-53, Glu-56 and Glu-57) that might be involved in interaction with an active-site-bound phospholipid molecule.	Phosphatidylcholines	46-65	phospholipase A2 group V	Homo sapiens	81-89
10839997-6	2000	Together, these steric and electrostatic properties of the active site of hVPLA(2) allow for effective binding and hydrolysis of a bulky cationic choline head group of phosphatidylcholine, which is unique among mammalian secretory PLA(2)s.	Phosphatidylcholines	168-187	phospholipase A2 group V	Homo sapiens	74-82
10839997-6	2000	Together, these steric and electrostatic properties of the active site of hVPLA(2) allow for effective binding and hydrolysis of a bulky cationic choline head group of phosphatidylcholine, which is unique among mammalian secretory PLA(2)s.	Phosphatidylcholines	168-187	phospholipase A2 group IIA	Homo sapiens	231-238
10873862-4	2000	PLD also catalyses a transphosphatidylation reaction in the presence of phosphatidylcholine and a short-chained primary or secondary alcohol.	Phosphatidylcholines	72-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
10835321-4	2000	At 1-2 days of age, lung saturated phosphatidylcholine (Sat PC) pool sizes were higher in wild-type, beta(c)(-/-), and GM(-/-) mice compared with wild-type adult mice.	Phosphatidylcholines	35-54	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Mus musculus	101-108
10845833-2	2000	Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD).	Phosphatidylcholines	0-20	superoxide dismutase 1	Homo sapiens	27-30
10845833-2	2000	Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD).	Phosphatidylcholines	0-20	superoxide dismutase 1	Homo sapiens	35-38
10845833-2	2000	Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD).	Phosphatidylcholines	0-20	superoxide dismutase 1	Homo sapiens	35-38
10861856-3	2000	Previous work from this laboratory using pharmacologic agents suggested that a phosphatidylcholine-specific phospholipase C and protein kinase C may be involved in early aspects of TGF-beta signaling.	Phosphatidylcholines	79-98	transforming growth factor beta 1	Homo sapiens	181-189
10856534-3	2000	Such an investigation was important because Lp-PLA(2) participates in the oxidative modification of low density lipoprotein by cleaving oxidised phosphatidylcholines, generating lysophosphatidylcholine and oxidised free fatty acids.	Phosphatidylcholines	145-165	phospholipase A2 group VII	Homo sapiens	44-53
10837365-6	2000	The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression.	Phosphatidylcholines	135-154	tumor necrosis factor	Homo sapiens	218-227
10837365-6	2000	The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression.	Phosphatidylcholines	135-154	tumor necrosis factor	Homo sapiens	338-347
10837365-6	2000	The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) because D609, a specific PC-PLC inhibitor, attenuated TNF-alpha-induced increases in production of diacyl-glycerol (DAG), a hydrolysis product of PC-PLC, and also attenuated TNF-alpha enhancement of ICAM-1 surface and gene expression.	Phosphatidylcholines	135-154	intercellular adhesion molecule 1	Homo sapiens	363-369
10843891-1	2000	Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates.	Phosphatidylcholines	250-269	prothrombin	Oryctolagus cuniculus	0-8
10843891-1	2000	Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates.	Phosphatidylcholines	250-269	phospholipase A2	Oryctolagus cuniculus	104-122
10843891-1	2000	Thrombin stimulation of rabbit ventricular myocytes activates a membrane-associated, Ca(2+)-independent phospholipase A(2) (PLA(2)) capable of hydrolyzing plasmenylcholine (choline plasmalogen), plasmanylcholine (alkylacyl choline phospholipid), and phosphatidylcholine substrates.	Phosphatidylcholines	250-269	phospholipase A2	Oryctolagus cuniculus	124-130
10845873-5	2000	Consistent with the reduction in cholesterol and phospholipid efflux in Tangier fibroblasts, downregulation of ABC1 expression by IFN-gamma also resulted in reduced phosphatidylcholine and sphingomyelin efflux to apolipoprotein A-I.	Phosphatidylcholines	165-184	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	111-115
10845873-5	2000	Consistent with the reduction in cholesterol and phospholipid efflux in Tangier fibroblasts, downregulation of ABC1 expression by IFN-gamma also resulted in reduced phosphatidylcholine and sphingomyelin efflux to apolipoprotein A-I.	Phosphatidylcholines	165-184	interferon gamma	Mus musculus	130-139
10809752-6	2000	The GM3-dependent c-Src phosphorylation response was enhanced when cholesterol and phosphatidylcholine were added.	Phosphatidylcholines	83-102	granulocyte macrophage antigen 3	Mus musculus	4-7
11401344-1	2000	The adsorption of lysozyme and cytochrome C on phosphatidylcholine liposomes essentially changes the physical properties of the phospholipid membranes and under certain circumstances greatly affects the stability of the colloid dispersion by inducing bridging liposome flocculation.	Phosphatidylcholines	47-66	lysozyme	Homo sapiens	18-26
11401344-1	2000	The adsorption of lysozyme and cytochrome C on phosphatidylcholine liposomes essentially changes the physical properties of the phospholipid membranes and under certain circumstances greatly affects the stability of the colloid dispersion by inducing bridging liposome flocculation.	Phosphatidylcholines	47-66	cytochrome c, somatic	Homo sapiens	31-43
10827979-6	2000	The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+).	Phosphatidylcholines	52-71	procollagen C-endopeptidase enhancer	Homo sapiens	140-148
10827979-6	2000	The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+).	Phosphatidylcholines	73-75	procollagen C-endopeptidase enhancer	Homo sapiens	140-148
10828088-9	2000	One of the PAF-like PC with an aldehydic terminal was found to be bioactive; it inhibited the production of nitric oxide induced by lipopolysaccharide and interferon-gamma in vascular smooth muscle cells from rat aorta.	Phosphatidylcholines	20-22	interferon gamma	Rattus norvegicus	155-171
10848624-4	2000	Yet, SFH proteins sharing low primary sequence similarity with Sec14p (i.e., Sfh2p, Sfh3p, Sfh4p, and Sfh5p) represent novel phosphatidylinositol transfer proteins (PITPs) that exhibit phosphatidylinositol- but not phosphatidylcholine-transfer activity in vitro.	Phosphatidylcholines	215-234	Csr1p	Saccharomyces cerevisiae S288C	77-82
10887963-3	2000	Here, we have studied the effects of increasing concentrations of bovine MBP charge isomer C1 (MBP/C1) on large unilamellar vesicles (LUVs) composed of phosphatidylcholine and phosphatidylserine (92:8 molar ratio), or with a lipid composition similar to that of the myelin membrane in vivo (Cyt-LUVs).	Phosphatidylcholines	152-171	myelin basic protein	Bos taurus	73-76
10799527-0	2000	A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14.	Phosphatidylcholines	169-188	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	87-92
10799527-0	2000	A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14.	Phosphatidylcholines	169-188	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	207-212
10799527-5	2000	The PSTB2 gene is allelic to the pleiotropic drug resistance gene, PDR17, and is homologous to SEC14, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein.	Phosphatidylcholines	139-158	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	67-72
10799527-5	2000	The PSTB2 gene is allelic to the pleiotropic drug resistance gene, PDR17, and is homologous to SEC14, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein.	Phosphatidylcholines	139-158	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	95-100
10887963-3	2000	Here, we have studied the effects of increasing concentrations of bovine MBP charge isomer C1 (MBP/C1) on large unilamellar vesicles (LUVs) composed of phosphatidylcholine and phosphatidylserine (92:8 molar ratio), or with a lipid composition similar to that of the myelin membrane in vivo (Cyt-LUVs).	Phosphatidylcholines	152-171	myelin basic protein	Bos taurus	95-98
10760824-1	2000	Phosphatidylethanolamine N-methyltransferase(PEMT) is an enzyme in liver that catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline.	Phosphatidylcholines	144-163	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	45-49
10760824-1	2000	Phosphatidylethanolamine N-methyltransferase(PEMT) is an enzyme in liver that catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline.	Phosphatidylcholines	214-233	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	45-49
10757993-7	2000	Nevertheless, aqueous TMX-1 partitioned strongly into membrane vesicles with apparent mole-fraction free-energy values of -7.1 kcal mol(-1) for phosphatidylcholine (POPC) vesicles and -8.2 kcal mol(-1) for phosphatidylglycerol (POPG) vesicles.	Phosphatidylcholines	144-163	thioredoxin related transmembrane protein 1	Homo sapiens	22-27
11200461-2	2000	These changes are conditioned by activation of phospholipase A2, which catalyses the deacylation of PL-glycerides predominantly phosphatidylcholines with the formation of high concentrations of lysophosphatidylcholines.	Phosphatidylcholines	128-148	phospholipase A2 group IB	Rattus norvegicus	47-63
10717249-9	2000	These are phosphatidylinositol-4, 5-bisphosphate-specific phospholipase C and phosphatidylethanolamine-specific phospholipase D. A positive feedback mechanism for DG production which includes these phospholipases, a phosphatidylcholine-specific phospholipase C and a phosphatidylcholine-specific phospholipase A2 has also been suggested.	Phosphatidylcholines	216-235	phospholipase A2 group IB	Homo sapiens	296-312
10764624-13	2000	In contrast, PFDA-treated rats showed a preference for ethanolamine, and PtdC was predominately synthesized through the PEMT pathway.	Phosphatidylcholines	73-77	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	120-124
10744775-0	2000	Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity.	Phosphatidylcholines	0-19	lecithin-cholesterol acyltransferase	Homo sapiens	50-86
10744775-6	2000	Even though fluidity was similar among the PC ether-containing rHDL, the order of PC reactivity with LCAT was significantly correlated (r(2) = 0.71) with that of 100% PC rHDL containing the same 18 carbon sn-2 fatty acyl chain species, suggesting that PC structure in the active site of LCAT determines reactivity in the absence of measurable differences in bilayer fluidity.	Phosphatidylcholines	82-84	lecithin-cholesterol acyltransferase	Homo sapiens	101-105
10744786-5	2000	The AOFA transfer rate from phosphatidylcholine-containing vesicles (POPC) to L-FABP is similar to that observed with another diffusional process, namely inter-membrane AOFA transfer.	Phosphatidylcholines	28-47	fatty acid binding protein 1	Homo sapiens	78-84
10744775-6	2000	Even though fluidity was similar among the PC ether-containing rHDL, the order of PC reactivity with LCAT was significantly correlated (r(2) = 0.71) with that of 100% PC rHDL containing the same 18 carbon sn-2 fatty acyl chain species, suggesting that PC structure in the active site of LCAT determines reactivity in the absence of measurable differences in bilayer fluidity.	Phosphatidylcholines	82-84	lecithin-cholesterol acyltransferase	Homo sapiens	287-291
10702314-7	2000	The treatment with phosphatidylcholine-specific phospholipase C (PC-PLC) inhibited macrophage proliferation, induced the expression of cytokines, and triggered a pattern of ERK activation equivalent to that induced by LPS.	Phosphatidylcholines	19-38	mitogen-activated protein kinase 1	Homo sapiens	173-176
10734122-1	2000	We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12).	Phosphatidylcholines	128-147	tumor necrosis factor	Mus musculus	31-58
10734122-1	2000	We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12).	Phosphatidylcholines	128-147	tumor necrosis factor	Mus musculus	60-68
10734122-1	2000	We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12).	Phosphatidylcholines	149-155	tumor necrosis factor	Mus musculus	31-58
10734122-1	2000	We investigated the effects of tumor necrosis factor alpha (TNFalpha), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine alveolar type II epithelial cell line (MLE-12).	Phosphatidylcholines	149-155	tumor necrosis factor	Mus musculus	60-68
10734122-7	2000	Addition of N-acetyl-Leu-Leu-Nle-CHO (ALLN), the calpain I inhibitor, or lactacystin, the 20 S proteasome inhibitor, blocked the inhibition of PtdCho biosynthesis mediated by TNFalpha.	Phosphatidylcholines	143-149	tumor necrosis factor	Mus musculus	175-183
10734122-11	2000	Thus, TNFalpha inhibits PtdCho synthesis by modulating CCT protein stability via the ubiquitin-proteasome and calpain-mediated proteolytic pathways.	Phosphatidylcholines	24-30	tumor necrosis factor	Mus musculus	6-14
10734122-11	2000	Thus, TNFalpha inhibits PtdCho synthesis by modulating CCT protein stability via the ubiquitin-proteasome and calpain-mediated proteolytic pathways.	Phosphatidylcholines	24-30	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	55-58
10720470-5	2000	Moreover, the rate of oxidation of pure phosphatidylcholine by Mb-H was found to be at least sevenfold greater than that observed for native myoglobin.	Phosphatidylcholines	40-59	myoglobin	Homo sapiens	141-150
10888232-5	2000	Since phosphatidylcholine is metabolized mainly by the action of phospholipase A2, with the release of arachidonic acid and other fatty acids, the effect of phosphocholine on arachidonic acid release in endothelial cells was also examined.	Phosphatidylcholines	6-25	phospholipase A2 group IB	Homo sapiens	65-81
10706593-1	2000	Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells.	Phosphatidylcholines	59-78	choline kinase beta	Mus musculus	0-27
10754262-3	2000	In this study LC-MS of phosphatidylcholines in human LDL treated either with HOCl or the myeloperoxidase system was used as a specific method to detect chlorohydrin and peroxide formation simultaneously, and with comparable sensitivity.	Phosphatidylcholines	23-43	myeloperoxidase	Homo sapiens	89-104
10692455-2	2000	The photosystem II core dimers were treated with phospholipase A2 (PL-A2), which cuts phosphatidylglycerol (PG) and phosphatidylcholine molecules at the sn-2 position.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Homo sapiens	49-65
10692455-2	2000	The photosystem II core dimers were treated with phospholipase A2 (PL-A2), which cuts phosphatidylglycerol (PG) and phosphatidylcholine molecules at the sn-2 position.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Homo sapiens	67-72
10706593-1	2000	Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells.	Phosphatidylcholines	59-78	choline kinase beta	Mus musculus	29-34
10677235-0	2000	Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid.	Phosphatidylcholines	72-91	mucin 7, secreted	Homo sapiens	0-3
10693931-4	2000	Our results showed that exogenously added apoE promoted the efflux of cholesterol and phosphatidylcholine from both astrocytes and neurons in culture, resulting in the generation of high-density lipoprotein-like particles.	Phosphatidylcholines	86-105	apolipoprotein E	Homo sapiens	42-46
10693931-7	2000	In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively.	Phosphatidylcholines	48-67	apolipoprotein E	Homo sapiens	80-84
10693931-7	2000	In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively.	Phosphatidylcholines	48-67	apolipoprotein E	Homo sapiens	182-186
10693931-7	2000	In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively.	Phosphatidylcholines	48-67	LDL receptor related protein 1	Homo sapiens	283-286
10684648-4	2000	We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS).	Phosphatidylcholines	232-251	apolipoprotein H	Homo sapiens	75-85
10684648-4	2000	We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS).	Phosphatidylcholines	253-255	apolipoprotein H	Homo sapiens	75-85
10737702-2	2000	All myeloma cell lines express a PAF acetylhydrolase activity and metabolize [3H]PAF and [3H]lyso PAF in 1-alkyl-2-acyl analogue of phosphatidylcholine.	Phosphatidylcholines	132-151	PCNA clamp associated factor	Homo sapiens	33-36
10751643-4	2000	Supplementation of THP-1 with AA (25 microM, 1 week) or EPA (25 microM, 1 week) led to their efficient incorporation, in comparable quantities and with similar distributions, into phosphatidylcholine and phosphatidylethanolamine, and to a lesser extent into phosphatidylinositol.	Phosphatidylcholines	180-199	GLI family zinc finger 2	Homo sapiens	19-24
10677235-0	2000	Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid.	Phosphatidylcholines	72-91	arachidonate 5-lipoxygenase	Homo sapiens	15-29
10842920-7	2000	The Fourier transform-infrared (FT-IR) study indicated in comparison with the model compounds that the CCl4-injected rats accumulated DAG in addition to phosphatidylcholine, phosphatidylethanolamine and triglyceride (TG) in the lipid membrane fraction of the liver homogenate.	Phosphatidylcholines	153-172	C-C motif chemokine ligand 4	Rattus norvegicus	103-107
10666121-8	2000	Selective expression of SP-D in the respiratory epithelium had no adverse effects on lung function, correcting surfactant phospholipid content and decreasing phosphatidylcholine incorporation significantly.	Phosphatidylcholines	158-177	surfactant associated protein D	Mus musculus	24-28
10666123-14	2000	Third, HGF is capable of significantly inhibiting the synthesis and secretion of the phosphatidylcholines of pulmonary surfactant.	Phosphatidylcholines	85-105	hepatocyte growth factor	Homo sapiens	7-10
10666123-15	2000	Fourth, HGF inhibits the rate-limiting enzyme in de novo phosphatidylcholine synthesis, CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15).	Phosphatidylcholines	57-76	hepatocyte growth factor	Homo sapiens	8-11
10666123-16	2000	Our data indicate that fibroblast-derived HGF could be partially responsible for the changes in surfactant dysfunction seen in adult respiratory distress syndrome, including the decreases seen in surfactant phosphatidylcholines.	Phosphatidylcholines	207-227	hepatocyte growth factor	Homo sapiens	42-45
10642495-1	2000	Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	92-107
10642495-1	2000	Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid.	Phosphatidylcholines	137-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-112
10898226-2	2000	Recently, we reported that lysophosphatidylcholine (L-PC), the PLA2 hydrolysis product of phosphatidylcholine (PC), stimulates bacterial translocation (BT) in an enterocyte cell-culture model.	Phosphatidylcholines	31-50	phospholipase A2 group IIA	Homo sapiens	63-67
10642356-4	2000	Cells isolated from rats given TNF-alpha had 26% lower levels of phosphatidylcholine compared with control.	Phosphatidylcholines	65-84	tumor necrosis factor	Rattus norvegicus	31-40
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Phosphatidylcholines	68-87	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Phosphatidylcholines	68-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	189-194
10821420-2	2000	The stimulatory effect of lipopolysaccharide on phosphatidylcholine secretion was additive to those of terbutaline and TPA (protein kinase A and C activators respectively) and this effect was not suppressed by inhibitors of both protein kinases.	Phosphatidylcholines	48-67	plasminogen activator, tissue type	Rattus norvegicus	119-122
10821420-2	2000	The stimulatory effect of lipopolysaccharide on phosphatidylcholine secretion was additive to those of terbutaline and TPA (protein kinase A and C activators respectively) and this effect was not suppressed by inhibitors of both protein kinases.	Phosphatidylcholines	48-67	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	124-140
10612714-6	2000	Phospholipid hydrolysis is less dependent on activator than triglycerides hydrolysis (100% and 300% of increase with apo CII for phosphatidyl-choline and triglycerides respectively).	Phosphatidylcholines	129-149	apolipoprotein C2	Bos taurus	117-124
10625607-2	2000	The difference between spectra recorded in the presence and absence of agonist from the nAChR reconstituted into 3:1:1 egg phosphatidylcholine (EPC)/DOPA/Chol membranes exhibits positive and negative bands that serve as markers of the structural changes associated with the resting to desensitized conformational change.	Phosphatidylcholines	123-142	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	88-93
10660303-1	2000	The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway.	Phosphatidylcholines	173-192	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	127-142
10660303-1	2000	The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway.	Phosphatidylcholines	173-192	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	144-147
11996112-5	2000	Electrospray mass spectrometry provided direct evidence that chlorohydrins rather than peroxides are the major products of HOCl- or MPO-treated LDL phosphatidylcholines.	Phosphatidylcholines	148-168	myeloperoxidase	Homo sapiens	132-135
11237195-4	2000	These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF.	Phosphatidylcholines	13-15	PCNA clamp associated factor	Homo sapiens	231-257
11237195-4	2000	These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF.	Phosphatidylcholines	13-15	PCNA clamp associated factor	Homo sapiens	259-262
11237195-4	2000	These unique PCs, formed by oxidative fragmentation of the polyunsaturated acyl group of the parent PC in liposomes, low density lipoproteins and blood plasma, induce platelet aggregation through the activation of the receptor for platelet-activating factor (PAF), due to their resemblance in structure with PAF.	Phosphatidylcholines	13-15	PCNA clamp associated factor	Homo sapiens	308-311
10898226-2	2000	Recently, we reported that lysophosphatidylcholine (L-PC), the PLA2 hydrolysis product of phosphatidylcholine (PC), stimulates bacterial translocation (BT) in an enterocyte cell-culture model.	Phosphatidylcholines	54-56	phospholipase A2 group IIA	Homo sapiens	63-67
10898226-8	2000	Thin-layer chromatography (TLC) was utilized to verify PLA2 hydrolysis of PC to L-PC.	Phosphatidylcholines	74-76	phospholipase A2 group IIA	Homo sapiens	55-59
10898226-13	2000	PLA2 mediates hydrolysis of PC to L-PC when both are applied to the apical surface of cultured enterocyte monolayers, resulting in increased BT and increased TEER with no damage to monolayer integrity.	Phosphatidylcholines	28-30	phospholipase A2 group IIA	Homo sapiens	0-4
10600179-6	1999	Finally, resveratrol inhibited PKCalpha when activated by phosphatidylcholine/phosphatidylserine vesicles with an IC(50) of 30 microM, whereas when the enzyme was activated by Triton X-100 micelles the IC(50) was 300 microM.	Phosphatidylcholines	58-77	protein kinase C alpha	Homo sapiens	31-39
10638197-2	1999	MTP catalyzes the transfer of triglyceride, cholesteryl ester and phosphatidylcholine between membranes and lipoproteins.	Phosphatidylcholines	66-85	microsomal triglyceride transfer protein	Rattus norvegicus	0-3
10591668-1	1999	We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions.	Phosphatidylcholines	194-214	phospholipase A2 group VII	Homo sapiens	29-70
10591668-1	1999	We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions.	Phosphatidylcholines	194-214	phospholipase A2 group VII	Homo sapiens	72-81
10591668-8	1999	It is concluded that (1) macrophages in both human and rabbit atherosclerotic lesions express Lp-PLA(2), which could cleave any oxidatively modified phosphatidylcholine present in the lesion area, and (2) modulation of Lp-PLA(2) activity could lead to antiatherogenic effects in the vessel wall.	Phosphatidylcholines	149-168	phospholipase A2 group VII	Homo sapiens	94-103
10561698-1	1999	CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane.	Phosphatidylcholines	67-86	cut like homeobox 1	Homo sapiens	0-3
10561698-1	1999	CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane.	Phosphatidylcholines	88-94	cut like homeobox 1	Homo sapiens	0-3
10561698-3	1999	Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid (AA), after ischemia/reperfusion.	Phosphatidylcholines	48-54	cut like homeobox 1	Homo sapiens	25-28
10561698-10	1999	CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4).	Phosphatidylcholines	34-40	cut like homeobox 1	Homo sapiens	0-3
10561698-10	1999	CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4).	Phosphatidylcholines	110-116	cut like homeobox 1	Homo sapiens	0-3
10746170-4	1999	The addition of P-9 to phosphatidylcholine (PC) liposomes containing cholesterol (Chol) gave rise to an increase of absorption intensity at around pH 4.0.	Phosphatidylcholines	23-42	exosome component 8	Homo sapiens	16-19
10746170-4	1999	The addition of P-9 to phosphatidylcholine (PC) liposomes containing cholesterol (Chol) gave rise to an increase of absorption intensity at around pH 4.0.	Phosphatidylcholines	44-46	exosome component 8	Homo sapiens	16-19
10746170-5	1999	The increase of turbidity by P-9 addition did not decrease with increasing pH, indicating P-9-mediated fusion of PC liposomes.	Phosphatidylcholines	113-115	exosome component 8	Homo sapiens	90-93
10746170-7	1999	The membrane fluidity close to the polar head groups of the fatty acyl chains of PC affected markedly the extent of P-9-mediated liposome fusion.	Phosphatidylcholines	81-83	exosome component 8	Homo sapiens	116-119
10783747-5	1999	Phosphatidylcholine, phosphatidylethanolamine and cardiolipin were decreased significantly by 40%, 49% and 60% respectively in CCl4 treated rats.	Phosphatidylcholines	0-19	C-C motif chemokine ligand 4	Rattus norvegicus	127-131
10562546-0	1999	Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling.	Phosphatidylcholines	105-124	phospholipase D1	Homo sapiens	33-49
10562546-0	1999	Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling.	Phosphatidylcholines	105-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154
10537140-0	1999	Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	320-339	interleukin 1 complex	Mus musculus	71-75
10537140-0	1999	Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	320-339	interleukin 6	Mus musculus	85-89
10567392-6	1999	The mature sPLA(2)-X induced the release of arachidonic acid from phosphatidylcholine more efficiently than other human sPLA(2) groups (IB, IIA, IID, and V) and elicited a prompt and marked release of arachidonic acid from human monocytic THP-1 cells compared with sPLA(2)-IB and -IIA with concomitant production of prostaglandin E(2).	Phosphatidylcholines	66-85	phospholipase A2 group X	Homo sapiens	11-20
10533050-5	1999	Analysis of the microsomal membrane fraction P(3) revealed that, in apoE-deficient mice, these membranes contain significantly lower levels of phosphatidylcholine (PC) than those of control mice.	Phosphatidylcholines	143-162	apolipoprotein E	Mus musculus	68-72
10533050-5	1999	Analysis of the microsomal membrane fraction P(3) revealed that, in apoE-deficient mice, these membranes contain significantly lower levels of phosphatidylcholine (PC) than those of control mice.	Phosphatidylcholines	164-166	apolipoprotein E	Mus musculus	68-72
10542105-3	1999	ApoC-II(19-39) forms approximately 60% alpha-helix upon binding to model egg yolk phosphatidylcholine small unilamellar vesicles.	Phosphatidylcholines	82-101	apolipoprotein C2	Homo sapiens	0-7
10707279-1	1999	Using fluorescent probes DSM and DSP-12, the effect of ribonuclease and lysozyme on the structural state of liposomes composed of phosphatidylcholine and diphosphatidylglycerol was studied.	Phosphatidylcholines	130-149	lysozyme	Homo sapiens	72-80
10548476-1	1999	Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups.	Phosphatidylcholines	105-124	phosphatidylethanolamine N-methyltransferase	Bos taurus	0-44
10548476-1	1999	Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups.	Phosphatidylcholines	105-124	phosphatidylethanolamine N-methyltransferase	Bos taurus	46-56
10604109-4	1999	The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 11	Homo sapiens	62-76
10552998-7	1999	As in vitro studies revealed that Mdr2 Pgp is not able to translocate these lipid analogues, we hypothesized that Mdr2 -/- mice had a reduced PC content of the exoplasmic canalicular membrane leaflet so that extraction of the short-chain lipid probes from this membrane by canalicular bile salts was impaired.	Phosphatidylcholines	142-144	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	114-118
10552998-11	1999	These data confirm that the efficiency of NBD-SM extraction depends on the lipid composition and suggest that the canalicular membrane outer leaflet of Mdr2 -/- mice has a reduced PC content.	Phosphatidylcholines	180-182	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	152-156
10529371-1	1999	Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP).	Phosphatidylcholines	67-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
10529371-1	1999	Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP).	Phosphatidylcholines	67-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
10529371-1	1999	Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP).	Phosphatidylcholines	88-90	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
10529371-1	1999	Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP).	Phosphatidylcholines	88-90	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
10529371-4	1999	Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC.	Phosphatidylcholines	257-259	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
10529371-4	1999	Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC.	Phosphatidylcholines	257-259	formyl peptide receptor 1	Homo sapiens	117-121
10654293-8	1999	Phosphorus NMR spectroscopy shows that phosphatidylcholine, phosphatidylinositol, sphingomyelin, and phosphatidylserine increase steadily from F15 to P21.	Phosphatidylcholines	39-58	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	150-153
10542325-1	1999	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	109-129	phosphatidylcholine transfer protein	Homo sapiens	0-36
10542325-1	1999	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro.	Phosphatidylcholines	109-129	phosphatidylcholine transfer protein	Homo sapiens	38-43
10529238-0	1999	Change in the positional specificity of lipoxygenase 1 due to insertion of fatty acids into phosphatidylcholine deoxycholate mixed micelles.	Phosphatidylcholines	92-111	seed linoleate 13S-lipoxygenase-1	Glycine max	40-54
10529238-3	1999	The fatty acids inserted into phosphatidylcholine micelles were better substrates for soybean lipoxygenase 1 (LOX1) with two distinct pH optima at 7.0 and 10.0.	Phosphatidylcholines	30-49	seed linoleate 13S-lipoxygenase-1	Glycine max	94-108
10529238-3	1999	The fatty acids inserted into phosphatidylcholine micelles were better substrates for soybean lipoxygenase 1 (LOX1) with two distinct pH optima at 7.0 and 10.0.	Phosphatidylcholines	30-49	seed linoleate 13S-lipoxygenase-1	Glycine max	110-114
10497177-4	1999	FXa generation at a rotating disc coated with TF embedded in a membrane composed of pure phosphatidylcholine (TF.PC) or 25% phosphatidylserine and 75% phosphatidylcholine (TF.PSPC) was measured in the presence of preformed complexes of FXa.TFPI(FL) or FXa.TFPI(1-161) (TFPI lacking the third Kunitz domain and C terminus).	Phosphatidylcholines	89-108	coagulation factor X	Homo sapiens	0-3
10497177-4	1999	FXa generation at a rotating disc coated with TF embedded in a membrane composed of pure phosphatidylcholine (TF.PC) or 25% phosphatidylserine and 75% phosphatidylcholine (TF.PSPC) was measured in the presence of preformed complexes of FXa.TFPI(FL) or FXa.TFPI(1-161) (TFPI lacking the third Kunitz domain and C terminus).	Phosphatidylcholines	151-170	coagulation factor X	Homo sapiens	0-3
10497200-10	1999	These results show that quite minor constituents of the LDL phosphatidylcholine pool are the exclusive precursors for PAF-like bioactivity in oxidized LDL.	Phosphatidylcholines	60-79	PCNA clamp associated factor	Homo sapiens	118-121
10604109-4	1999	The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2.	Phosphatidylcholines	140-159	phosphoglycolate phosphatase	Homo sapiens	77-80
10473578-0	1999	Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) --&gt; G(1) transition.	Phosphatidylcholines	123-142	solute carrier family 25 member 1	Homo sapiens	13-52
10500206-1	1999	Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function.	Phosphatidylcholines	77-96	phosphatidylcholine transfer protein	Mus musculus	0-36
10500206-1	1999	Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function.	Phosphatidylcholines	77-96	phosphatidylcholine transfer protein	Mus musculus	38-43
10504221-4	1999	Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide.	Phosphatidylcholines	38-57	surfactant protein C	Homo sapiens	59-61
10504221-4	1999	Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide.	Phosphatidylcholines	38-57	myristoylated alanine rich protein kinase C substrate	Homo sapiens	120-126
10473578-2	1999	We examined the rates of phosphatidylcholine (PC) synthesis and the activity, membrane affinity, and intracellular localization of the rate-limiting enzyme in the synthesis of PC, CTP:phosphocholine cytidylyltransferase (CT) during this transition.	Phosphatidylcholines	176-178	solute carrier family 25 member 1	Homo sapiens	180-219
10484608-6	1999	The addition of phosphatidylcholine liposomes substantially increased cholesterol efflux from apoE-expressing and non-expressing J774 cells.	Phosphatidylcholines	16-35	apolipoprotein E	Mus musculus	94-98
10465754-1	1999	The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques.	Phosphatidylcholines	91-110	proopiomelanocortin	Homo sapiens	55-69
10462379-1	1999	The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	43-45	phosphatidylethanolamine N-methyltransferase	Mus musculus	190-194
10462379-4	1999	The PC concentration in gallbladder bile of mice that synthesize PC mainly via the CDP-choline pathway was comparable with control mice that synthesize PC via both pathways, whereas it was reduced by approximately 40% in mice that synthesize PC via the PEMT pathway.	Phosphatidylcholines	4-6	phosphatidylethanolamine N-methyltransferase	Mus musculus	253-257
10412048-1	1999	We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	166-185	fibroblast growth factor 2	Mus musculus	26-56
10412048-1	1999	We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	166-185	fibroblast growth factor 2	Mus musculus	58-62
10412048-1	1999	We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	166-185	interleukin 6	Mus musculus	225-238
10412048-1	1999	We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	166-185	interleukin 6	Mus musculus	240-244
10412048-1	1999	We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	166-185	fibroblast growth factor 2	Mus musculus	259-263
10462379-1	1999	The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway.	Phosphatidylcholines	22-41	phosphatidylethanolamine N-methyltransferase	Mus musculus	190-194
10484608-8	1999	On the other hand, even in the presence of phosphatidylcholine liposomes, cholesterol efflux rates remained significantly higher from apoE-expressing macrophages than non-expressing cells.	Phosphatidylcholines	43-62	apolipoprotein E	Homo sapiens	134-138
10507691-1	1999	We describe the inhibitory effect of A beta (25-35) fragment of amyloid-beta peptide and bradykinin (BK) on phosphatidylcholine (PtdCho) metabolism in immortalized rat brain GP8.39 endothelial cells (EC).	Phosphatidylcholines	108-127	amyloid beta precursor protein	Rattus norvegicus	37-43
10461922-4	1999	Under optimal conditions, the iPLA2 revealed the following substrate preference toward the fatty acid chain in the sn-2 position of phosphatidylcholine: linoleoyl &gt; palmitoyl &gt; oleoyl &gt; arachidonoyl.	Phosphatidylcholines	132-151	phospholipase A2 group VI	Rattus norvegicus	30-35
10507691-1	1999	We describe the inhibitory effect of A beta (25-35) fragment of amyloid-beta peptide and bradykinin (BK) on phosphatidylcholine (PtdCho) metabolism in immortalized rat brain GP8.39 endothelial cells (EC).	Phosphatidylcholines	129-135	amyloid beta precursor protein	Rattus norvegicus	37-43
10507691-3	1999	The BK (10 microM) stimulation of cells brought about an increase in conjugated dienes and LDH release only after 4 h. Following 24 h treatment with 50 microM A beta peptide, the [Me-3H]choline incorporation into PtdCho strongly decreased while the [3H]choline release increased, indicating PtdCho hydrolysis.	Phosphatidylcholines	213-219	amyloid beta precursor protein	Rattus norvegicus	159-165
10448079-0	1999	Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.	Phosphatidylcholines	13-32	ATP binding cassette subfamily B member 4	Homo sapiens	36-40
10446298-1	1999	We have investigated the wasp venom peptides mastoparan X and polistes mastoparan regarding their apparent potential to induce pore-like defects in phosphatidylcholine unilamellar vesicles.	Phosphatidylcholines	148-167	WASP actin nucleation promoting factor	Homo sapiens	25-29
10446285-1	1999	Resonance energy transfer between a series of lipid-bound fluorescent probes as donors and the heme group of cytochrome c as acceptor has been used to obtain structural information on the protein complexes with model membranes, composed of phosphatidylcholine and cardiolipin.	Phosphatidylcholines	240-259	cytochrome c, somatic	Homo sapiens	109-121
10448079-0	1999	Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.	Phosphatidylcholines	13-32	ATP binding cassette subfamily B member 1	Homo sapiens	89-93
10448079-2	1999	We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics.	Phosphatidylcholines	41-60	ATP binding cassette subfamily B member 1	Homo sapiens	28-32
10448079-2	1999	We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics.	Phosphatidylcholines	41-60	phosphoglycolate phosphatase	Homo sapiens	33-37
10448079-2	1999	We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics.	Phosphatidylcholines	41-60	ATP binding cassette subfamily B member 4	Homo sapiens	74-78
10448079-6	1999	Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low.	Phosphatidylcholines	92-111	ATP binding cassette subfamily B member 1	Homo sapiens	46-50
10448079-6	1999	Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low.	Phosphatidylcholines	92-111	phosphoglycolate phosphatase	Homo sapiens	51-55
10448079-6	1999	Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low.	Phosphatidylcholines	92-111	ATP binding cassette subfamily B member 1	Homo sapiens	133-137
10486736-4	1999	Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was also utilized to confirm the phosphatidylcholine, a substrate of sPLA2.	Phosphatidylcholines	110-129	phospholipase A2 group X	Homo sapiens	146-151
10448079-6	1999	Comparison of C12-NBD-PC to that of the model MDR1 P-gp substrate, rhodamine-123, indicated phosphatidylcholine turnover kinetics by MDR1 P-gp to be relatively low.	Phosphatidylcholines	92-111	phosphoglycolate phosphatase	Homo sapiens	138-142
10448079-7	1999	The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype.	Phosphatidylcholines	30-49	ATP binding cassette subfamily B member 1	Homo sapiens	17-21
10448079-7	1999	The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype.	Phosphatidylcholines	30-49	phosphoglycolate phosphatase	Homo sapiens	22-26
10448079-7	1999	The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype.	Phosphatidylcholines	30-49	phosphoglycolate phosphatase	Homo sapiens	100-104
10448079-7	1999	The transport by MDR1 P-gp of phosphatidylcholine from inner to outer membrane leaflet may regulate P-gp function and fulfill a role in the MDR1 multidrug-resistant phenotype.	Phosphatidylcholines	30-49	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
10441140-0	1999	Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles.	Phosphatidylcholines	27-47	phospholipase A2, major isoenzyme	Sus scrofa	51-67
10432300-1	1999	Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn).	Phosphatidylcholines	131-150	phosphatidylserine synthase 1	Homo sapiens	92-115
10441140-1	1999	Hydrolysis of monodisperse short chain phosphatidylcholines, far below their critical micelle concentration, by phospholipase A2 (PLA2) and other interfacial enzymes is characterized.	Phosphatidylcholines	39-59	phospholipase A2, major isoenzyme	Sus scrofa	112-128
10441140-1	1999	Hydrolysis of monodisperse short chain phosphatidylcholines, far below their critical micelle concentration, by phospholipase A2 (PLA2) and other interfacial enzymes is characterized.	Phosphatidylcholines	39-59	phospholipase A2, major isoenzyme	Sus scrofa	130-134
10425393-1	1999	While yeast contain multiple phospholipase D activities, only one, encoded by SPO14, appears to be a member of the phosphatidylcholine-specific phospholipase D gene family.	Phosphatidylcholines	115-134	phospholipase D	Saccharomyces cerevisiae S288C	78-83
10469152-3	1999	Phosphatidylcholine liposomes were treated by octylglucoside to insert a glycosyl-PtdIns-protein, alkaline phosphatase (ALP), some cholesterol, and a GlySph, the lactocerebroside.	Phosphatidylcholines	0-19	alkaline phosphatase, placental	Homo sapiens	98-118
10469152-3	1999	Phosphatidylcholine liposomes were treated by octylglucoside to insert a glycosyl-PtdIns-protein, alkaline phosphatase (ALP), some cholesterol, and a GlySph, the lactocerebroside.	Phosphatidylcholines	0-19	alkaline phosphatase, placental	Homo sapiens	120-123
10517269-1	1999	In cholinergic neurons choline is directed to three main pathways; (1) conversion to phosphorylcholine (PCh) and cytidine diphosphate choline (CDP-choline) for the synthesis of phosphatidylcholine, (2) acylation to the neurotransmitter acetylcholine and (3) oxidation to betaine for the formation of methionine.	Phosphatidylcholines	177-196	cut like homeobox 1	Homo sapiens	143-146
10419523-2	1999	The rate of PLCdelta1 hydrolysis of phosphatidylinositol 4,5-bisphosphate was stimulated 20-fold by phosphatidylserine (PS), 4-fold by phosphatidic acid (PA), and not at all by phosphatidylethanolamine or phosphatidylcholine (PC).	Phosphatidylcholines	205-224	phospholipase C delta 1	Homo sapiens	12-21
10425391-2	1999	Virtually every cell uses phosphatidylcholine as substrate to produce phosphatidic acid in a controlled reaction catalyzed by specific PLD isoforms.	Phosphatidylcholines	26-45	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
10425393-1	1999	While yeast contain multiple phospholipase D activities, only one, encoded by SPO14, appears to be a member of the phosphatidylcholine-specific phospholipase D gene family.	Phosphatidylcholines	115-134	phospholipase D	Saccharomyces cerevisiae S288C	144-159
10409698-6	1999	Purified NAP-22 bound to the liposomes that were made from phosphatidylcholine and cholesterol.	Phosphatidylcholines	59-78	brain abundant membrane attached signal protein 1	Homo sapiens	9-15
10395737-5	1999	For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively.	Phosphatidylcholines	64-83	glutathione S-transferase alpha 1	Homo sapiens	51-59
10415339-1	1999	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that promotes intermembrane transfer of phosphatidylcholines but no other phospholipids.	Phosphatidylcholines	123-143	phosphatidylcholine transfer protein	Rattus norvegicus	0-36
10415339-1	1999	Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that promotes intermembrane transfer of phosphatidylcholines but no other phospholipids.	Phosphatidylcholines	123-143	phosphatidylcholine transfer protein	Rattus norvegicus	38-43
10413522-1	1999	Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption.	Phosphatidylcholines	247-266	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	223-230
10413522-1	1999	Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption.	Phosphatidylcholines	247-266	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	235-242
10395737-5	1999	For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively.	Phosphatidylcholines	64-83	glutathione S-transferase alpha 2	Homo sapiens	241-249
10411684-7	1999	"Flip flop" was gauged by preferential decrements in phosphatidylserine (PS) versus phosphatidylcholine (PC; PS/PC ratios) in response to extracellular (Naja) PLA2 exposure.	Phosphatidylcholines	84-103	phospholipase A2, group IB, pancreas	Mus musculus	159-163
10383445-1	1999	We have developed a simple fluorescent assay for detection of phospholipase A2 (PLA2) activity in zebrafish embryos that utilizes a fluorescent phosphatidylcholine substrate.	Phosphatidylcholines	144-163	phospholipase A2, group IB (pancreas)	Danio rerio	62-78
10383445-1	1999	We have developed a simple fluorescent assay for detection of phospholipase A2 (PLA2) activity in zebrafish embryos that utilizes a fluorescent phosphatidylcholine substrate.	Phosphatidylcholines	144-163	phospholipase A2, group IB (pancreas)	Danio rerio	80-84
10383445-8	1999	By using a quenched BODIPY-labeled phosphatidylcholine that fluoresces only upon cleavage by PLA2, lipase activity was visualized in the cells of living embryos where it localized to perinuclear membranes.	Phosphatidylcholines	35-54	phospholipase A2, group IB (pancreas)	Danio rerio	93-97
10375402-2	1999	Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline.	Phosphatidylcholines	135-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	44-48
10375402-2	1999	Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline.	Phosphatidylcholines	135-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-54
10375402-2	1999	Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline.	Phosphatidylcholines	135-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-54
10375402-2	1999	Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline.	Phosphatidylcholines	135-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-54
10375402-2	1999	Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline.	Phosphatidylcholines	135-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-112
10393333-0	1999	Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase.	Phosphatidylcholines	23-43	lecithin-cholesterol acyltransferase	Homo sapiens	90-126
10393333-1	1999	The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated.	Phosphatidylcholines	102-121	lecithin-cholesterol acyltransferase	Homo sapiens	28-64
10393333-1	1999	The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated.	Phosphatidylcholines	102-121	lecithin-cholesterol acyltransferase	Homo sapiens	66-70
10393333-1	1999	The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated.	Phosphatidylcholines	123-125	lecithin-cholesterol acyltransferase	Homo sapiens	28-64
10393333-1	1999	The possible involvement of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of oxidized phosphatidylcholine (PC) in plasma was investigated.	Phosphatidylcholines	123-125	lecithin-cholesterol acyltransferase	Homo sapiens	66-70
10393333-4	1999	In the present study, we found that LCAT produces various metabolites from oxidized PC and that oxidized PC molecules in LDL particles serve as substrates.	Phosphatidylcholines	84-86	lecithin-cholesterol acyltransferase	Homo sapiens	36-40
10393333-13	1999	These results suggest that LCAT is capable of metabolizing a variety of oxidized products of PC and preventing the accumulation of oxidized PC in circulating LDL particles.	Phosphatidylcholines	93-95	lecithin-cholesterol acyltransferase	Homo sapiens	27-31
10393333-13	1999	These results suggest that LCAT is capable of metabolizing a variety of oxidized products of PC and preventing the accumulation of oxidized PC in circulating LDL particles.	Phosphatidylcholines	140-142	lecithin-cholesterol acyltransferase	Homo sapiens	27-31
10395967-0	1999	Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2.	Phosphatidylcholines	14-33	phospholipase A2	Cricetulus griseus	69-85
10395967-9	1999	Glycerophosphocholine is the PtdCho catabolite that accumulates in the transfected cells, which suggests that PtdCho turnover is mediated by a phospholipase A2 (PLA2).	Phosphatidylcholines	29-35	phospholipase A2	Cricetulus griseus	143-159
10395967-9	1999	Glycerophosphocholine is the PtdCho catabolite that accumulates in the transfected cells, which suggests that PtdCho turnover is mediated by a phospholipase A2 (PLA2).	Phosphatidylcholines	29-35	phospholipase A2	Cricetulus griseus	161-165
10395969-1	1999	To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects.	Phosphatidylcholines	170-190	phospholipase A2 group VII	Homo sapiens	40-82
10395969-1	1999	To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects.	Phosphatidylcholines	170-190	phospholipase A2 group VII	Homo sapiens	84-90
10395969-1	1999	To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects.	Phosphatidylcholines	170-190	lecithin-cholesterol acyltransferase	Homo sapiens	96-132
10395969-1	1999	To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects.	Phosphatidylcholines	170-190	lecithin-cholesterol acyltransferase	Homo sapiens	134-138
10347126-0	1999	Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin-treated rat.	Phosphatidylcholines	72-91	ATP binding cassette subfamily B member 4	Rattus norvegicus	15-19
10397762-4	1999	We now report that, in addition to a dramatic accumulation of phosphatidylinositol-4-phosphate, sac1 mutants also exhibit a specific acceleration of phosphatidylcholine biosynthesis via the CDP-choline pathway.	Phosphatidylcholines	149-168	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	96-100
10397762-5	1999	This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase.	Phosphatidylcholines	5-24	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	114-120
10397762-5	1999	This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase.	Phosphatidylcholines	5-24	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	124-128
10397762-5	1999	This phosphatidylcholine metabolic phenotype is sensitive to the two physiological challenges that abolish bypass Sec14p in sac1 strains; i.e. phospholipase D inactivation and expression of bacterial diacylglycerol (DAG) kinase.	Phosphatidylcholines	5-24	phospholipase D	Saccharomyces cerevisiae S288C	143-158
10411659-10	1999	The rate of phosphatidylcholine synthesis was barely affected, but mass was moderately reduced by a 48-h treatment of cells with IL-1beta.	Phosphatidylcholines	12-31	interleukin 1 beta	Homo sapiens	129-137
10411659-11	1999	Finally, the efflux of cell [3H]cholesterol, [3H]sphingomyelin, and [3H]phosphatidylcholine to lipid-free apolipoprotein A-I was markedly increased from cells treated with IL-1beta for 24 and 48 h. We conclude that long-term exposure of cells to IL-1beta had marked effects on the cellular homeostasis of cholesterol and choline-containing phospholipids.	Phosphatidylcholines	72-91	interleukin 1 beta	Homo sapiens	172-180
10336610-2	1999	PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns).	Phosphatidylcholines	48-67	phospholipase C delta 3	Homo sapiens	0-10
10336610-2	1999	PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns).	Phosphatidylcholines	69-75	phospholipase C delta 3	Homo sapiens	0-10
10336610-2	1999	PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns).	Phosphatidylcholines	80-86	phospholipase C delta 3	Homo sapiens	0-10
10341225-8	1999	ATP also stimulated a rapid increase in choline, and inhibition of phosphatidylcholine hydrolysis blocked ATP-evoked ERK activation.	Phosphatidylcholines	67-86	Eph receptor B1	Rattus norvegicus	117-120
10341225-9	1999	These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors.	Phosphatidylcholines	231-250	Eph receptor B1	Rattus norvegicus	166-169
10341225-9	1999	These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors.	Phosphatidylcholines	231-250	Eph receptor B1	Rattus norvegicus	166-169
10341225-9	1999	These results indicate that P2Y receptors in astrocytes are coupled independently to PI-PLC/calcium and ERK pathways and suggest that signaling from P2Y receptors to ERK involves a calcium-independent PKC isoform and hydrolysis of phosphatidylcholine by phospholipase D. In addition, we found that inhibition of ERK activation blocked extracellular ATP-stimulated DNA synthesis, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y receptors.	Phosphatidylcholines	231-250	Eph receptor B1	Rattus norvegicus	166-169
10320809-8	1999	In the sn-1 to -2 transfer, the sn-1 acyl residue of 1-acyl-sn-glycero-3-phosphocholine was transferred to not only the sn-2 positions of 1-acyl-sn-glycero-3-phosphocholine, but also 1-acyl-sn-glycero-3-phosphoethanolamine, producing phosphatidylcholine and phosphatidylethanolamine, respectively.	Phosphatidylcholines	234-253	heterogeneous nuclear ribonucleoprotein U	Rattus norvegicus	7-17
10230818-9	1999	The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters.	Phosphatidylcholines	72-91	phospholipase A2, group IB, pancreas	Mus musculus	57-61
10318801-2	1999	A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells.	Phosphatidylcholines	48-67	phospholipase A2, group VI	Mus musculus	24-29
10318801-2	1999	A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells.	Phosphatidylcholines	48-67	phospholipase A2, group VI	Mus musculus	175-180
10318801-2	1999	A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells.	Phosphatidylcholines	70-72	phospholipase A2, group VI	Mus musculus	24-29
10318801-2	1999	A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells.	Phosphatidylcholines	70-72	phospholipase A2, group VI	Mus musculus	175-180
10329685-12	1999	Whereas the EKI1 gene product was primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, the CKI1 gene product was primarily responsible for phosphatidylcholine synthesis via the CDP-choline pathway.	Phosphatidylcholines	181-200	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	133-137
10224048-7	1999	Together, our data provide a long sought mechanism as to how defects in Sac1p overcome certain actin mutants and bypass the requirement for yeast phosphatidylinositol/phosphatidylcholine transfer protein, Sec14p.	Phosphatidylcholines	167-186	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	72-77
10224048-7	1999	Together, our data provide a long sought mechanism as to how defects in Sac1p overcome certain actin mutants and bypass the requirement for yeast phosphatidylinositol/phosphatidylcholine transfer protein, Sec14p.	Phosphatidylcholines	167-186	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	205-211
10381281-1	1999	Phosphatidylcholines (1-O-alcoxy-2-amino-2-desoxy-phosphocholines and 1-pyrene-labeled analogs) were synthesized and used to examine interactions with recombinant human PAF-acetylhydrolase (PAF-AH), an enzyme purified from plasma, and with macrophage-like U937 cells.	Phosphatidylcholines	0-20	phospholipase A2 group VII	Homo sapiens	169-188
10230818-9	1999	The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters.	Phosphatidylcholines	51-53	phospholipase A2, group IB, pancreas	Mus musculus	57-61
10207008-2	1999	We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem.	Phosphatidylcholines	65-84	phospholipase A2 group IIA	Homo sapiens	40-44
10198439-5	1999	Specifically, the response to nitrogen limitation is dependent upon the presence of a functional OPI1 gene product, it requires ongoing phosphatidylcholine biosynthesis and it is mediated by the repeated element, UASINO, found in the promoter of INO1 and other co-regulated genes of phospholipid biosynthesis.	Phosphatidylcholines	136-155	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	97-101
10198439-5	1999	Specifically, the response to nitrogen limitation is dependent upon the presence of a functional OPI1 gene product, it requires ongoing phosphatidylcholine biosynthesis and it is mediated by the repeated element, UASINO, found in the promoter of INO1 and other co-regulated genes of phospholipid biosynthesis.	Phosphatidylcholines	136-155	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	246-250
10207000-5	1999	Dimeric Ymt was shown to have PLD-like activity as demonstrated by the hydrolysis of phosphatidylcholine.	Phosphatidylcholines	85-104	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	30-33
10207008-2	1999	We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem.	Phosphatidylcholines	65-84	phospholipase A2 group IIA	Homo sapiens	48-52
10207008-2	1999	We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem.	Phosphatidylcholines	86-88	phospholipase A2 group IIA	Homo sapiens	40-44
10207008-2	1999	We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and Cho, W. (1998) Biochem.	Phosphatidylcholines	86-88	phospholipase A2 group IIA	Homo sapiens	48-52
10191259-1	1999	Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol.	Phosphatidylcholines	71-90	cut like homeobox 1	Homo sapiens	163-166
10216289-1	1999	CTP:phosphocholine cytidylyltransferase plays a key role in regulating the rate of phosphatidylcholine biosynthesis.	Phosphatidylcholines	83-102	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
10086319-3	1999	The administration of tiadenol, DEHP, or clofibric acid slightly, but significantly, increased, in common, the activity of CTP:phosphocholine cytidylyltransferase, a key enzyme for the synthesis de novo of PtdCho, and suppressed the activity of PtdEtn N-methyltransferase.	Phosphatidylcholines	206-212	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	123-162
10191259-1	1999	Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol.	Phosphatidylcholines	92-98	cut like homeobox 1	Homo sapiens	163-166
10198353-6	1999	Cessation of aerosolized GM-CSF for 5 wk resulted in increased saturated phosphatidylcholine pool sizes that returned to pretreatment levels.	Phosphatidylcholines	73-92	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	25-31
10196168-7	1999	Similarly, treatment of acetyl LDL with phospholipase A2 converted more than 90% of the initial content of phosphatidylcholine (PC) to lyso-PC, but the phospholipase A2-treated acetyl LDL was nearly 10-fold less potent than oxidized LDL at stimulating growth.	Phosphatidylcholines	128-130	phospholipase A2 group IB	Homo sapiens	40-56
10092620-11	1999	Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC.	Phosphatidylcholines	23-29	glycophorin E (MNS blood group)	Homo sapiens	124-127
10092620-11	1999	Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC.	Phosphatidylcholines	78-84	glycophorin E (MNS blood group)	Homo sapiens	124-127
10196168-7	1999	Similarly, treatment of acetyl LDL with phospholipase A2 converted more than 90% of the initial content of phosphatidylcholine (PC) to lyso-PC, but the phospholipase A2-treated acetyl LDL was nearly 10-fold less potent than oxidized LDL at stimulating growth.	Phosphatidylcholines	107-126	phospholipase A2 group IB	Homo sapiens	40-56
10096907-1	1999	We determined the orientation of a biotinylated version of the pore-forming peptide GALA (WEAALAEALAEALAEHLAEALAEALEALAA) at pH 5.0 in large unilamellar phosphatidylcholine vesicles, using the enhancement of BODIPY-avidin fluorescence subsequent to its irreversible binding to a biotin moiety.	Phosphatidylcholines	153-172	galactosidase alpha	Homo sapiens	84-88
10353318-4	1999	The sialidase-treated LPL also showed similar hydrolyzing activity for triolein emulsified with Triton X-100, phosphatidylcholine and phosphatidylethanolamine, whereas it showed significantly increased hydrolyzing activity for triolein emulsified with phosphatidylserine and cardiolipin (152% and 183%, compared with untreated LPL, respectively).	Phosphatidylcholines	110-129	lipoprotein lipase	Homo sapiens	22-25
10194607-6	1999	Although both types of tested liposomes induced similar cellular changes, only liposomes made of pure egg yolk phosphatidylcholine induced a transient increase in serum TNF-alpha levels.	Phosphatidylcholines	111-130	tumor necrosis factor	Mus musculus	169-178
10319417-3	1999	When linoleic acids micelles or phosphatidylcholine liposomes were incubated with Cu,Zn-SOD and H2O2, lipid peroxidation was gradually increased in a time-dependent manner.	Phosphatidylcholines	32-51	superoxide dismutase 1	Homo sapiens	88-91
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	93-112	lipoprotein(a)	Homo sapiens	29-43
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	93-112	lipoprotein(a)	Homo sapiens	45-49
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	93-112	phospholipase A2 group IB	Homo sapiens	55-71
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	93-112	phospholipase A2 group IB	Homo sapiens	73-77
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	114-116	lipoprotein(a)	Homo sapiens	29-43
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	114-116	lipoprotein(a)	Homo sapiens	45-49
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	114-116	phospholipase A2 group IB	Homo sapiens	55-71
10191282-1	1999	In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold.	Phosphatidylcholines	114-116	phospholipase A2 group IB	Homo sapiens	73-77
10322420-4	1999	These processes involve the regulation of the CDP-choline and phosphatidylethanolamine-methylation pathways of phosphatidylcholine synthesis, CTP synthetase, phospholipase D and the phospholipid-transfer protein Sec14p.	Phosphatidylcholines	111-130	cut like homeobox 1	Homo sapiens	46-49
10101272-3	1999	In addition, we have found a PPAR-independent mechanism in which fibrates, known peroxisome proliferators, decrease hepatic secretion of very low density lipoproteins (VLDL) through inhibition of phosphatidylcholine synthesis via methylation of phosphatidylethanolamine (PE) (T. Nishimaki-Mogami et al., Biochim.	Phosphatidylcholines	196-215	peroxisome proliferator activated receptor alpha	Rattus norvegicus	29-33
10101264-1	1999	CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading.	Phosphatidylcholines	98-117	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
10218592-3	1999	The reaction kinetics of lecithin-cholesterol acyltransferase with reconstitued high density lipoproteins were studied in the presence of 0.6 and 1.2 microM hydroperoxides of phosphatidylcholine.	Phosphatidylcholines	175-194	lecithin-cholesterol acyltransferase	Homo sapiens	25-61
10101264-1	1999	CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading.	Phosphatidylcholines	119-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
10082883-1	1999	Cytidine and choline, present in cytidine 5"-diphosphate choline (CDP-choline), are major precursors of the phosphatidylcholine found in cell membranes and important regulatory elements in phosphatide biosynthesis.	Phosphatidylcholines	108-127	cut-like homeobox 1	Rattus norvegicus	66-69
10082883-2	1999	Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine.	Phosphatidylcholines	215-234	cut-like homeobox 1	Rattus norvegicus	18-21
10082883-2	1999	Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine.	Phosphatidylcholines	215-234	cut-like homeobox 1	Rattus norvegicus	136-139
10218592-6	1999	Nevertheless, hydroperoxides of phosphatidylcholine altered the reactivity of lecithin-cholesterol acyltransferase for reconstitued high density lipoproteins suggesting either an alteration of the binding of lecithin-cholesterol acyltransferase to the reconstitued high density lipoproteins or a competitive inhibition mechanism.	Phosphatidylcholines	32-51	lecithin-cholesterol acyltransferase	Homo sapiens	78-114
10218592-6	1999	Nevertheless, hydroperoxides of phosphatidylcholine altered the reactivity of lecithin-cholesterol acyltransferase for reconstitued high density lipoproteins suggesting either an alteration of the binding of lecithin-cholesterol acyltransferase to the reconstitued high density lipoproteins or a competitive inhibition mechanism.	Phosphatidylcholines	32-51	lecithin-cholesterol acyltransferase	Homo sapiens	208-244
10037681-1	1999	Mammalian phosphatidylcholine-specific phospholipase D1 (PLD1) is a signal transduction-activated enzyme thought to function in multiple cell biological settings including the regulation of membrane vesicular trafficking.	Phosphatidylcholines	10-29	phospholipase D1	Homo sapiens	39-55
10037681-1	1999	Mammalian phosphatidylcholine-specific phospholipase D1 (PLD1) is a signal transduction-activated enzyme thought to function in multiple cell biological settings including the regulation of membrane vesicular trafficking.	Phosphatidylcholines	10-29	phospholipase D1	Homo sapiens	57-61
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	152-171	protein kinase C alpha	Homo sapiens	38-41
10037768-2	1999	Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles.	Phosphatidylcholines	77-96	protein C receptor	Homo sapiens	21-25
10037768-2	1999	Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles.	Phosphatidylcholines	77-96	thrombomodulin	Homo sapiens	30-44
10037768-2	1999	Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles.	Phosphatidylcholines	77-96	thrombomodulin	Homo sapiens	46-48
10049506-7	1999	Interestingly, although PKC-alpha also mediates the stimulatory effect of PMA on the synthesis of PtdCho by a phosphorylation mechanism, overexpression of holo PKC-epsilon or its regulatory domain fragments did not affect PMA-induced PtdCho synthesis.	Phosphatidylcholines	98-104	protein kinase C alpha	Homo sapiens	24-33
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	152-171	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	152-171	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	152-171	protein kinase C alpha	Homo sapiens	222-231
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	173-179	protein kinase C alpha	Homo sapiens	38-41
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	173-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
10073990-10	1999	Moreover, this phenomenon appears to result not only from the significantly elevated PC to free cholesterol ratio (1.54:1) in dense LDL particles (1.15:1 to 1.25:1 for other LDL subclasses) but also from their unique structural features, including a distinct apoB100 conformation, which may facilitate covalent bond formation between oxidized CE and apoB100.	Phosphatidylcholines	85-87	apolipoprotein B	Homo sapiens	259-266
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Phosphatidylcholines	173-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
10073990-10	1999	Moreover, this phenomenon appears to result not only from the significantly elevated PC to free cholesterol ratio (1.54:1) in dense LDL particles (1.15:1 to 1.25:1 for other LDL subclasses) but also from their unique structural features, including a distinct apoB100 conformation, which may facilitate covalent bond formation between oxidized CE and apoB100.	Phosphatidylcholines	85-87	apolipoprotein B	Homo sapiens	350-357
10217630-3	1999	The reciprocal nature of the decrease in phosphatidylcholine concentration, compared with the increase in the concentration of 1-lysophosphatidylcholine and 2-lysophosphatidylcholine, suggested a substrate/product relationship consistent with the activities of phospholipase A1 and phospholipase A2, respectively.	Phosphatidylcholines	41-60	lipase H	Homo sapiens	261-277
10217630-3	1999	The reciprocal nature of the decrease in phosphatidylcholine concentration, compared with the increase in the concentration of 1-lysophosphatidylcholine and 2-lysophosphatidylcholine, suggested a substrate/product relationship consistent with the activities of phospholipase A1 and phospholipase A2, respectively.	Phosphatidylcholines	41-60	phospholipase A2 group IB	Homo sapiens	282-298
10072552-0	1999	A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages.	Phosphatidylcholines	2-21	cyclin dependent kinase 20	Homo sapiens	71-74
10087440-1	1999	Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	74-93	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
10087440-1	1999	Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	74-93	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	80-99	heparan sulfate proteoglycan 2	Homo sapiens	134-137
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	80-99	cyclin dependent kinase 20	Homo sapiens	170-173
10194059-2	1999	These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells.	Phosphatidylcholines	124-143	Rac family small GTPase 1	Homo sapiens	262-266
10194059-2	1999	These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells.	Phosphatidylcholines	124-143	H3 histone pseudogene 16	Homo sapiens	268-271
10079112-3	1999	Analysis of plasma of F2 homozygous PLTP-/- mice showed complete loss of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, sphingomyelin, and partial loss of free cholesterol transfer activities.	Phosphatidylcholines	73-92	phospholipid transfer protein	Mus musculus	36-40
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	80-99	mitogen-activated protein kinase 1	Homo sapiens	178-181
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidylcholines	91-110	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	101-103	heparan sulfate proteoglycan 2	Homo sapiens	134-137
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	101-103	cyclin dependent kinase 20	Homo sapiens	170-173
10072552-1	1999	This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS.	Phosphatidylcholines	101-103	mitogen-activated protein kinase 1	Homo sapiens	178-181
10094474-2	1999	It was confirmed that the oxidation of human low density lipoprotein (LDL) by 15-LOX from rabbit reticulocytes gave phosphatidylcholine (PC) and cholesteryl ester (CE) hydroperoxides regio-, stereo- and enantio-specifically.	Phosphatidylcholines	116-135	arachidonate 15-lipoxygenase	Homo sapiens	78-84
10094474-2	1999	It was confirmed that the oxidation of human low density lipoprotein (LDL) by 15-LOX from rabbit reticulocytes gave phosphatidylcholine (PC) and cholesteryl ester (CE) hydroperoxides regio-, stereo- and enantio-specifically.	Phosphatidylcholines	137-139	arachidonate 15-lipoxygenase	Homo sapiens	78-84
10094474-3	1999	15-LOX also oxidized human plasma to give specific PC and CE hydroperoxides in spite of the presence of high concentrations of antioxidants.	Phosphatidylcholines	51-53	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-6
9989927-2	1999	This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine.	Phosphatidylcholines	139-158	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-106
9989927-2	1999	This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine.	Phosphatidylcholines	139-158	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
10026263-4	1999	TF reconstituted into phosphatidylcholine vesicles was ineffective as a cofactor for the factor VIIa cleavage of factor V. However, incorporation of phosphatidylethanolamine in the vesicles had little effect over the presence of 20% phosphatidylserine.	Phosphatidylcholines	22-41	coagulation factor III, tissue factor	Homo sapiens	0-2
10082810-3	1999	Among cells exposed to NGF (0-116 h), the labeling of DAG from [3H]glycerol peaked earlier than that of [3H]PC, and the specific radioactivity of [3H]glycerol-labeled DAG was much higher than those of the [3H]phospholipids, indicating that [3H]DAG synthesis precedes [3H]phospholipid synthesis.	Phosphatidylcholines	108-110	nerve growth factor	Rattus norvegicus	23-26
10082810-4	1999	NGF treatment also increased (by 50-330%) the incorporation of monounsaturated ([3H]oleic acid) and polyunsaturated ([14C]linoleic acid or [3H]arachidonic acid) fatty acids into DAG, and, by 15-70%, into PC.	Phosphatidylcholines	204-206	nerve growth factor	Rattus norvegicus	0-3
9920915-1	1999	Activation of phosphatidylcholine-specific phospholipase D (PLD) has been proposed to play roles in numerous cellular pathways including signal transduction and membrane vesicular trafficking.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-63
10030391-4	1999	In contrast with CETP, serum PLTP activity, as measured as the rate of radiolabeled phosphatidylcholine transferred from liposomes toward serum HDL, was significantly higher with the lauric acid diet (23.5+/2.6%) than with the palmitic acid diet (22.5+/-2.5%) (P = 0.0013), while no significant differences were noted when comparing the saturated diets versus the oleic acid diet (23.0+/-2.3%).	Phosphatidylcholines	84-103	phospholipid transfer protein	Homo sapiens	29-33
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidylcholines	91-110	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10048791-3	1999	No studies have examined phospholipase D hydrolysis of the three subclasses of phosphatidylcholine in interleukin-8-stimulated neutrophils.	Phosphatidylcholines	79-98	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
10048791-7	1999	Our findings suggest that phospholipase D catalyses the hydrolysis of diacyl, alkylacyl and alkenylacyl subclasses of phosphatidylcholine in neutrophils upon IL-8 stimulation.	Phosphatidylcholines	118-137	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
9873061-1	1999	The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine.	Phosphatidylcholines	112-131	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	30-45
9914152-6	1999	For this study, the fluorescent sterol cholestatrienol (C-3) was incorporated into platelet membranes by exchange from cholesterol-containing phosphatidylcholine small unilamellar vesicles.	Phosphatidylcholines	142-161	complement C3	Homo sapiens	56-59
10075017-3	1999	When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609.	Phosphatidylcholines	113-133	interleukin 1 beta	Mus musculus	21-29
10075017-3	1999	When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609.	Phosphatidylcholines	113-133	transforming growth factor, beta 1	Mus musculus	31-39
10075017-3	1999	When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609.	Phosphatidylcholines	113-133	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	164-167
9878788-9	1999	D609 which inhibits phosphatidylcholine-specific phospholipase-C (PLC), potently inhibited both CDP-DG accumulation and inositol phosphate formation.	Phosphatidylcholines	20-39	cut-like homeobox 1	Rattus norvegicus	96-99
9873061-1	1999	The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine.	Phosphatidylcholines	112-131	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	47-50
9989271-1	1999	Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Homo sapiens	94-138
9989271-1	1999	Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Homo sapiens	140-144
9915331-8	1999	Propofol inhibited vasopressin-induced activation of phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D, but this effect of propofol was significant only at supraclinical concentration (0.1 mM).	Phosphatidylcholines	102-121	arginine vasopressin	Rattus norvegicus	19-30
10728571-9	1999	PC biosynthesis seemed to be carried out through the CDP-choline pathway, which was stimulated in the oncogenic cells, whereas PE was more likely, a product of phosphatidylserine decarboxylation rather than the CDP-ethanolamine pathway.	Phosphatidylcholines	0-2	cut like homeobox 1	Homo sapiens	53-56
10216475-1	1999	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis.	Phosphatidylcholines	75-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-40
10216475-1	1999	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis.	Phosphatidylcholines	75-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-45
10216475-1	1999	Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis.	Phosphatidylcholines	75-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	198-201
9888879-7	1999	HDL3- and apolipoprotein (apo) A-I-mediated cellular cholesterol and phosphatidylcholine efflux was examined by labeling cells with [3H]cholesterol and [3H]choline, respectively, during growth and cholesterol loading during growth arrest.	Phosphatidylcholines	69-88	HDL3	Homo sapiens	0-4
9854020-1	1999	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine.	Phosphatidylcholines	123-142	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
9854020-1	1999	Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine.	Phosphatidylcholines	123-142	phosphatidylethanolamine N-methyltransferase	Homo sapiens	46-50
9854020-8	1999	PEMT activity decreased, the levels of PEMT2 mRNA decreased and there was an increase in the activity of CTP:phosphocholine cytidylyltransferase, a key regulatory enzyme in the CDP-choline pathway of phosphatidylcholine biosynthesis.	Phosphatidylcholines	200-219	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-4
9867870-1	1999	The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-63
9886817-1	1999	Studies were performed to determine the effects of PTH and related compounds on phosphatidylcholine (PC) hydrolysis in UMR-106 cells and the pathway by which the PTH effects occurred.	Phosphatidylcholines	80-99	parathyroid hormone	Rattus norvegicus	51-54
9867870-1	1999	The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments.	Phosphatidylcholines	14-33	phospholipase D1	Homo sapiens	73-77
9867870-1	1999	The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments.	Phosphatidylcholines	14-33	phospholipase D2	Homo sapiens	82-86
10025671-6	1999	The cytosolic PLA2 (cPLA2) inhibitor, arachidonyl trifluoromethyl ketone, was found to inhibit ATP-stimulated PC secretion, whereas the secretory PLA2 inhibitors, oleoyloxyethylphosphocholine, aristolochic acid, or p-bromophenacyl bromide, and the Ca2+-independent PLA2 inhibitors, palmitoyl trifluoromethyl ketone, or haloenol lactone suicide substrate, had no effect.	Phosphatidylcholines	110-112	phospholipase A2 group IVA	Rattus norvegicus	4-18
10025671-6	1999	The cytosolic PLA2 (cPLA2) inhibitor, arachidonyl trifluoromethyl ketone, was found to inhibit ATP-stimulated PC secretion, whereas the secretory PLA2 inhibitors, oleoyloxyethylphosphocholine, aristolochic acid, or p-bromophenacyl bromide, and the Ca2+-independent PLA2 inhibitors, palmitoyl trifluoromethyl ketone, or haloenol lactone suicide substrate, had no effect.	Phosphatidylcholines	110-112	phospholipase A2 group IVA	Rattus norvegicus	20-25
10027763-3	1999	In lecithinized SOD, 4 molecules of a phosphatidylcholine derivative were covalently bound to each dimer of recombinant human copper-zinc SOD to facilitate tissue accumulation.	Phosphatidylcholines	38-57	superoxide dismutase 1	Homo sapiens	16-19
9886255-6	1999	However, the phosphatidylcholine-specific PLC inhibitor D609 abrogates cell spreading without affecting adhesion to fibronectin in these cells as well as the CD3/CD28-activated T cells.	Phosphatidylcholines	13-32	CD28 molecule	Homo sapiens	162-166
10050072-0	1999	Endothelin-1 stimulates hydrolysis of phosphatidylcholine by phospholipases C and D in intact rat mesenteric arteries.	Phosphatidylcholines	38-57	endothelin 1	Rattus norvegicus	0-12
10027763-3	1999	In lecithinized SOD, 4 molecules of a phosphatidylcholine derivative were covalently bound to each dimer of recombinant human copper-zinc SOD to facilitate tissue accumulation.	Phosphatidylcholines	38-57	superoxide dismutase 1	Homo sapiens	138-141
9841875-3	1998	Here it is shown that only in the presence of both Ca2+ and phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine can a prothrombin dimer be chemically cross-linked.	Phosphatidylcholines	94-113	coagulation factor II, thrombin	Homo sapiens	143-154
10100195-9	1999	It is plausible that the decreased activity of phosphatidylethanolamine-N-methyltransferase and its low compensating ability could relate to the modification of phosphatidylcholine in brain tissues from Alzheimer"s disease patients.	Phosphatidylcholines	161-180	phosphatidylethanolamine N-methyltransferase	Homo sapiens	47-91
12114973-1	1999	The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells.	Phosphatidylcholines	149-168	protein kinase C alpha	Homo sapiens	117-120
12114973-1	1999	The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells.	Phosphatidylcholines	149-168	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	194-197
12114973-1	1999	The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells.	Phosphatidylcholines	149-168	protein kinase C alpha	Homo sapiens	117-120
12114973-1	1999	The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells.	Phosphatidylcholines	149-168	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	301-304
9857049-7	1998	Pure ACAT-1 dispersed in mixed micelles containing sodium taurocholate, phosphatidylcholine, and cholesterol remains catalytically active.	Phosphatidylcholines	72-91	acetyl-CoA acetyltransferase 1	Homo sapiens	5-11
10192509-3	1999	LPC is formed by hydrolysis of phosphatidylcholine (PC) in LDL and cell membranes, induced by phospholipase A2 or by oxidation.	Phosphatidylcholines	31-50	phospholipase A2 group IB	Homo sapiens	94-110
10192509-3	1999	LPC is formed by hydrolysis of phosphatidylcholine (PC) in LDL and cell membranes, induced by phospholipase A2 or by oxidation.	Phosphatidylcholines	1-3	phospholipase A2 group IB	Homo sapiens	94-110
9861024-8	1998	Hepatic lipase may prevent such vesicular lipoproteins from accumulating in apo E-deficient mice by hydrolyzing phosphatidyl choline as scavenger receptor B1 removes the cholesteryl esters and by gradual endocytosis of lipoproteins bound to hepatic lipase on the surface of hepatocytes.	Phosphatidylcholines	112-132	lipase, hepatic	Mus musculus	0-14
9861024-8	1998	Hepatic lipase may prevent such vesicular lipoproteins from accumulating in apo E-deficient mice by hydrolyzing phosphatidyl choline as scavenger receptor B1 removes the cholesteryl esters and by gradual endocytosis of lipoproteins bound to hepatic lipase on the surface of hepatocytes.	Phosphatidylcholines	112-132	lipase, hepatic	Mus musculus	241-255
9826612-4	1998	For phosphatidylcholine also spin-labeled at the 8 position of the sn-2 chain, this ratio was reversed: the relaxation enhancement by Ni2+ ions was half that induced by molecular oxygen.	Phosphatidylcholines	4-23	spindlin 1	Homo sapiens	29-33
9858696-3	1998	Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight.	Phosphatidylcholines	149-168	proteolipid protein 1	Homo sapiens	37-40
9858696-3	1998	Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight.	Phosphatidylcholines	170-172	proteolipid protein 1	Homo sapiens	37-40
9858696-3	1998	Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight.	Phosphatidylcholines	195-197	proteolipid protein 1	Homo sapiens	37-40
9924985-4	1998	The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect.	Phosphatidylcholines	57-76	phospholipase A2, group IB, pancreas	Mus musculus	92-96
9924985-4	1998	The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect.	Phosphatidylcholines	78-80	phospholipase A2, group IB, pancreas	Mus musculus	92-96
9924985-6	1998	The results demonstrated that the arachidonic acid-containing PC and PA molecules induced a more pronounced increase of membrane-associated PLA2 activity in ras-transformed cells compared to the corresponding palmitate-stearate- or oleate- containing molecular species.	Phosphatidylcholines	62-64	phospholipase A2, group IB, pancreas	Mus musculus	140-144
9826612-6	1998	For a double-labeled system, in which both N-biotinyl phosphatidylethanolamine and phosphatidylcholine were spin-labeled on the 12 C atom of the sn-2 chain, the relaxation rate in the absence of avidin was greater than that predicted from linear additivity of the corresponding singly labeled systems, because of mutual spin-spin interactions between the two labeled lipid species.	Phosphatidylcholines	83-102	spindlin 1	Homo sapiens	108-112
10081149-2	1998	The result demonstrated the necessity of phosphatidylcholine (PC) for optimal ATPase activity and phosphatidylethanolamine (PE) for the optimal calcium transport activity.	Phosphatidylcholines	41-60	dynein axonemal heavy chain 8	Homo sapiens	78-84
10081149-2	1998	The result demonstrated the necessity of phosphatidylcholine (PC) for optimal ATPase activity and phosphatidylethanolamine (PE) for the optimal calcium transport activity.	Phosphatidylcholines	62-64	dynein axonemal heavy chain 8	Homo sapiens	78-84
9874205-1	1998	The SEC14 gene of Saccharomyces cerevisiae codes for a phosphatidylinositol-transfer protein (Sec14p(sc)) which is capable of transferring both phosphatidylinositol and phosphatidylcholine between membranes in vitro.	Phosphatidylcholines	169-188	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	4-9
9885772-9	1998	In general, PC appears to promote the translocation of apo B from the cytosol to the lumen of the endoplasmic reticulum, a step that is crucial in the early stages of VLDL assembly.	Phosphatidylcholines	12-14	apolipoprotein B	Homo sapiens	55-60
9874205-1	1998	The SEC14 gene of Saccharomyces cerevisiae codes for a phosphatidylinositol-transfer protein (Sec14p(sc)) which is capable of transferring both phosphatidylinositol and phosphatidylcholine between membranes in vitro.	Phosphatidylcholines	169-188	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	94-100
9831630-0	1998	Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I.	Phosphatidylcholines	73-92	apolipoprotein A1	Homo sapiens	154-172
9831631-1	1998	The microsomal triglyceride transfer protein (MTP) catalyzes the transfer of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces.	Phosphatidylcholines	114-133	microsomal triglyceride transfer protein	Homo sapiens	4-44
9831631-1	1998	The microsomal triglyceride transfer protein (MTP) catalyzes the transfer of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces.	Phosphatidylcholines	114-133	microsomal triglyceride transfer protein	Homo sapiens	46-49
9879668-0	1998	The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.	Phosphatidylcholines	87-106	tumor necrosis factor	Rattus norvegicus	27-54
9879668-0	1998	The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.	Phosphatidylcholines	87-106	interleukin 1 beta	Rattus norvegicus	59-76
9879668-5	1998	These results suggest that tumor necrosis factor alpha or interleukin-1beta stimulate phosphatidylcholine secretion via protein kinase C activation in a Ca2+-independent manner.	Phosphatidylcholines	86-105	tumor necrosis factor	Rattus norvegicus	27-54
9879668-5	1998	These results suggest that tumor necrosis factor alpha or interleukin-1beta stimulate phosphatidylcholine secretion via protein kinase C activation in a Ca2+-independent manner.	Phosphatidylcholines	86-105	interleukin 1 beta	Rattus norvegicus	58-75
9822688-11	1998	With this assay, we showed for the first time that rPLRP2 prefers phosphatidylglycerol and ethanolamine over phosphatidylcholine.	Phosphatidylcholines	109-128	pancreatic lipase related protein 2	Rattus norvegicus	51-57
9804870-1	1998	The complexes of hemoglobin and cytochrome c with liposomes composed of phosphatidylcholine and its mixtures with cardiolipin and cholesterol have been studied by monitoring resonance energy transfer between fluorescent probe 3-methoxybenzanthrone as donor and heme groups of the proteins as acceptors.	Phosphatidylcholines	72-91	cytochrome c, somatic	Homo sapiens	32-44
9862448-2	1998	Incorporation of [3H]palmitic acid into phosphatidylcholine (PC) and sphingomyelin (SM) was altered within 15-30 min after modifying the extracellular Mg2+ ion level ([Mg2+]o).	Phosphatidylcholines	61-63	mucin 7, secreted	Homo sapiens	151-154
9862448-2	1998	Incorporation of [3H]palmitic acid into phosphatidylcholine (PC) and sphingomyelin (SM) was altered within 15-30 min after modifying the extracellular Mg2+ ion level ([Mg2+]o).	Phosphatidylcholines	61-63	mucin 7, secreted	Homo sapiens	168-171
9819208-2	1998	We report here new data concerning the nature of the interaction of apoA-I with condensed phospholipid (PL) monolayers (phosphatidylcholine and phosphatidylserine).	Phosphatidylcholines	120-139	apolipoprotein A1	Homo sapiens	68-74
9792687-4	1998	We now report that the IGF-I-dependent increase in nuclear DAG production can be inhibited by the specific phosphatidylinositol phospholipase C inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine or by neomycin sulfate but not by the purported phosphatidylcholine-phospholipase C specific inhibitor D609 or by inhibitors of phospholipase D-mediated DAG generation.	Phosphatidylcholines	254-273	insulin-like growth factor 1	Mus musculus	23-28
9813240-1	1998	Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
9774404-8	1998	This conclusion is based on the finding that binding of the monoclonal antibody ESH8 to the C2 domain, which is known to prevent this conformational transition, resulted in fVIIIa binding to PS/phosphatidylcholine/phosphatidylethanolamine vesicles (4/76/20) with a lower affinity similar to that of fVIII.	Phosphatidylcholines	194-213	coagulation factor VIII	Homo sapiens	173-178
9815113-9	1998	In both control and dexamethasone-treated explants, TGF-beta1 (10 ng/ml) also decreased fatty acid synthetase mRNA, protein, and enzyme activity and the rate of [3H]choline incorporation into phosphatidylcholine.	Phosphatidylcholines	192-211	transforming growth factor beta 1	Homo sapiens	52-61
9848395-10	1998	Furthermore, Rb1 reduces the phosphatidylcholine production by inhibiting the methyl-transferase I and II, and the reduction of phosphatidylcholine production inhibits leukotriene release.	Phosphatidylcholines	29-48	LOW QUALITY PROTEIN: retinoblastoma-associated protein	Cavia porcellus	13-16
9802889-3	1998	Mdr2-deficient mice lack Mdr2 P-glycoprotein, the canalicular translocator for phosphatidylcholine, and secrete virtually no phospholipid and cholesterol in bile.	Phosphatidylcholines	79-98	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-4
9807043-8	1998	Simultaneously, we investigated sequential changes in the activities of phospholipase A2 and phospholipase C, which release peroxidized membrane phospholipids into the cytoplasm via hydrolysis, as well as the relationship between changes in the kidney tissue phospholipid composition (sphingomyelin/phosphatidylcholine ratio) and renal function.	Phosphatidylcholines	299-318	phospholipase A2 group IB	Rattus norvegicus	72-108
9786921-3	1998	Sphingomyelinase (SMase) and phospholipase A2 (PLA2) have been found in the arterial wall, and, moreover, lesional LDL shows signs of hydrolysis of both sphingomyelin and phosphatidylcholine.	Phosphatidylcholines	171-190	phospholipase A2 group IB	Homo sapiens	29-45
9786921-3	1998	Sphingomyelinase (SMase) and phospholipase A2 (PLA2) have been found in the arterial wall, and, moreover, lesional LDL shows signs of hydrolysis of both sphingomyelin and phosphatidylcholine.	Phosphatidylcholines	171-190	phospholipase A2 group IB	Homo sapiens	47-51
9774472-4	1998	Whereas no abnormalities were observed in SP-D (+/-) mice, alveolar and tissue phosphatidylcholine pool sizes were markedly increased in SP-D (-/-) mice.	Phosphatidylcholines	79-98	surfactant associated protein D	Mus musculus	137-141
9774404-2	1998	We found that binding of heterotrimeric fVIIIa (A1.A2.A3-C1-C2) to synthetic vesicles with a physiologic content of 4% phosphatidylserine (PS), 76% phosphatidylcholine, and 20% phosphatidylethanolamine occurs with a 10-fold higher affinity than that of factor VIII (fVIII).	Phosphatidylcholines	148-167	coagulation factor VIII	Homo sapiens	40-45
9778355-5	1998	The greatest degree of peptide 1H/2H exchange (95%) under nondenaturing conditions was found for the nAChR reconstituted into the highly fluid egg phosphatidylcholine membranes lacking cholesterol and anionic lipids at pH 9.0.	Phosphatidylcholines	147-166	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	101-106
9767142-0	1998	Unmyristoylated MARCKS-related protein (MRP) binds to supported planar phosphatidylcholine membranes.	Phosphatidylcholines	71-90	MARCKS like 1	Homo sapiens	16-38
9765216-2	1998	Hepatocytes have a second pathway for the synthesis of phosphatidylcholine, a stepwise methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase and encoded by the Pempt gene.	Phosphatidylcholines	55-74	phosphatidylethanolamine N-methyltransferase	Mus musculus	205-210
9765216-3	1998	We report that when Pempt-deficient mice were fed a choline-deficient diet for 3 days, severe liver pathology occurred apparently due to a lack of phosphatidylcholine biosynthesis.	Phosphatidylcholines	147-166	phosphatidylethanolamine N-methyltransferase	Mus musculus	20-25
9765216-6	1998	We suggest that the Pempt gene has been maintained during evolution to provide phosphatidylcholine when dietary choline is insufficient, as might occur during starvation or pregnancy.	Phosphatidylcholines	79-98	phosphatidylethanolamine N-methyltransferase	Mus musculus	20-25
9767142-0	1998	Unmyristoylated MARCKS-related protein (MRP) binds to supported planar phosphatidylcholine membranes.	Phosphatidylcholines	71-90	MARCKS like 1	Homo sapiens	40-43
9788614-2	1998	After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids.	Phosphatidylcholines	178-197	phospholipase A2, group IB, pancreas	Mus musculus	102-118
9788614-2	1998	After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids.	Phosphatidylcholines	178-197	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	120-125
9755106-5	1998	Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin.	Phosphatidylcholines	64-83	phospholipase A2 group X	Homo sapiens	47-52
9767089-1	1998	The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues.	Phosphatidylcholines	189-208	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	4-8
9767089-1	1998	The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues.	Phosphatidylcholines	210-212	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	4-8
9767089-1	1998	The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues.	Phosphatidylcholines	239-241	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	4-8
9767089-5	1998	These results suggest that PCs with short acyl residues were taken up by the cho1/pss mutant and remodeled as they were used, and that PCs with short acyl residues do not inhibit conversion of PE to PC.	Phosphatidylcholines	27-29	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	77-81
9746498-5	1998	With phosphatidylcholine as substrate, TNF-alpha decreased both cytosolic and membrane-associated iPLA2 activities.	Phosphatidylcholines	5-24	tumor necrosis factor	Rattus norvegicus	39-48
9746498-5	1998	With phosphatidylcholine as substrate, TNF-alpha decreased both cytosolic and membrane-associated iPLA2 activities.	Phosphatidylcholines	5-24	phospholipase A2 group VI	Rattus norvegicus	98-103
9748300-8	1998	Moreover, geranylgeraniol and farnesol induced a rapid inhibition of phosphatidylcholine biosynthesis at the last step of the CDP-choline pathway controlled by choline phosphotransferase and not at the level of CTP:phosphocholine cytidylyltransferase, the key enzyme of the pathway.	Phosphatidylcholines	69-88	cut like homeobox 1	Homo sapiens	126-129
9755106-5	1998	Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin.	Phosphatidylcholines	85-87	phospholipase A2 group X	Homo sapiens	47-52
9726932-5	1998	Reconstitution of rhodopsin into phosphatidylcholine vesicles has little influence on the spectral properties of the rhodopsin-transducin complex, whereas pH affects the intensity of the carbonyl stretching band.	Phosphatidylcholines	33-52	rhodopsin	Bos taurus	18-27
9763531-11	1998	Over 24 hours, human apolipoprotein (apo) A-I, apoHDL reconstituted with phosphatidylcholine, and HDL3 respectively removed 46.6+/-3.7%, 61.	Phosphatidylcholines	73-92	apolipoprotein A1	Homo sapiens	21-45
9761774-1	1998	Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes.	Phosphatidylcholines	30-49	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
9761774-1	1998	Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes.	Phosphatidylcholines	30-49	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
9788244-0	1998	Submicellar bile salts stimulate phosphatidylcholine transfer activity of sterol carrier protein 2.	Phosphatidylcholines	33-52	sterol carrier protein 2	Homo sapiens	74-98
9798980-3	1998	The interaction of beta2-GPI with unilamellar vesicles containing varying amounts of acidic phospholipids with phosphatidylcholine (PC) was measured at equilibrium via relative light scattering.	Phosphatidylcholines	111-130	apolipoprotein H	Homo sapiens	19-28
9798980-3	1998	The interaction of beta2-GPI with unilamellar vesicles containing varying amounts of acidic phospholipids with phosphatidylcholine (PC) was measured at equilibrium via relative light scattering.	Phosphatidylcholines	132-134	apolipoprotein H	Homo sapiens	19-28
9753449-0	1998	Modulation of the positional specificity of lecithin-cholesterol acyltransferase by the acyl group composition of its phosphatidylcholine substrate: role of the sn-1-acyl group.	Phosphatidylcholines	118-137	lecithin-cholesterol acyltransferase	Homo sapiens	44-80
9753449-1	1998	Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6.	Phosphatidylcholines	103-122	lecithin-cholesterol acyltransferase	Homo sapiens	6-42
9753449-1	1998	Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6.	Phosphatidylcholines	103-122	lecithin-cholesterol acyltransferase	Homo sapiens	44-48
9753449-1	1998	Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6.	Phosphatidylcholines	124-126	lecithin-cholesterol acyltransferase	Homo sapiens	6-42
9753449-1	1998	Human lecithin-cholesterol acyltransferase (LCAT), which is normally specific for the sn-2 position of phosphatidylcholine (PC), derives a significant percentage of acyl groups from the sn-1 position, when sn-2 is occupied by 18:0, 20:4, or 22:6.	Phosphatidylcholines	124-126	lecithin-cholesterol acyltransferase	Homo sapiens	44-48
9735345-2	1998	On phosphatidylcholine or especially dipalmitoylphosphatidylcholine monolayers, SP-A at roughly 0.005 mg/ml formed large numbers of fibers and elaborate fibrous networks.	Phosphatidylcholines	3-22	pulmonary surfactant-associated protein A	Bos taurus	80-84
9724516-8	1998	Studies on the influence of quinacrine on the activity of PLA2 toward pyrene-labeled phospholipid analogues revealed that the hydrolysis of phosphatidylcholine was progressively reduced as a function of increasing [quinacrine].	Phosphatidylcholines	140-159	phospholipase A2 group IB	Homo sapiens	58-62
9876331-11	1998	During stimulation with endothelin-1 and phorbolester, but not phenylephrine, phosphatidylcholine becomes an increasingly important source for 1,2-diacylglycerol due to sustained activation of phospholipase D. The 1,2-diacylglycerol level remains relatively constant during agonist stimulation which strongly indicates that particular molecular species of 1,2-diacylglycerol more than its total concentration determine the activation of protein kinase C isoenzymes.	Phosphatidylcholines	78-97	endothelin 1	Rattus norvegicus	24-36
9799116-5	1998	Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	138-157	phospholipase C delta 3	Homo sapiens	47-57
9799116-5	1998	Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho).	Phosphatidylcholines	159-165	phospholipase C delta 3	Homo sapiens	47-57
9802015-9	1998	The proportion of the predominant phospholipid, phosphatidylcholine, exhibited a profile that was the inverse of the phosphatidylinositol content: phosphatidylcholine content was lowest in opi1 cells in stationary phase.	Phosphatidylcholines	48-67	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	189-193
9802015-9	1998	The proportion of the predominant phospholipid, phosphatidylcholine, exhibited a profile that was the inverse of the phosphatidylinositol content: phosphatidylcholine content was lowest in opi1 cells in stationary phase.	Phosphatidylcholines	147-166	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	189-193
9873837-1	1998	Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation by GPC: choline phosphodiesterase (GPC: choline PDE).	Phosphatidylcholines	113-132	phospholipase A2 group IB	Canis lupus familiaris	164-180
9873837-1	1998	Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation by GPC: choline phosphodiesterase (GPC: choline PDE).	Phosphatidylcholines	113-132	phospholipase A2 group IB	Canis lupus familiaris	182-186
9748327-8	1998	Although this enzyme shows a modest ( approximately 50%) reduction in activity when anionic substrates are used under standard assay conditions, the activity of the enzyme on phosphatidylcholine vesicles and cell membranes is dramatically increased compared with human sPLA2.	Phosphatidylcholines	175-194	phospholipase A2 group IIA	Homo sapiens	269-274
9729268-1	1998	Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses.	Phosphatidylcholines	237-256	nerve growth factor	Rattus norvegicus	84-103
9705332-6	1998	Interestingly, cPLA2-gamma demonstrates a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.	Phosphatidylcholines	98-117	phospholipase A2 group IVC	Homo sapiens	15-26
9727944-3	1998	The most significant changes were increases in the concentration of the glycolytic intermediate, fructose-1,6-bisphosphate and in the concentration of CDP-choline, which is an intermediate in phosphatidylcholine biosynthesis.	Phosphatidylcholines	192-211	cut like homeobox 1	Homo sapiens	151-154
9729268-1	1998	Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses.	Phosphatidylcholines	237-256	nerve growth factor	Rattus norvegicus	105-108
9729268-1	1998	Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses.	Phosphatidylcholines	67-69	nerve growth factor	Rattus norvegicus	84-103
9729268-1	1998	Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses.	Phosphatidylcholines	67-69	nerve growth factor	Rattus norvegicus	105-108
9820649-2	1998	The activation of phospholipases A2, C and D (PLA2, PLC and PLD) acting on phosphatidylcholine and phosphatidylethanolamine was determined by high performance liquid chromatography (HPLC) separation and liquid scintillation counting of water- and lipid-soluble phospholipid metabolites.	Phosphatidylcholines	75-94	LOC104974671	Bos taurus	18-44
9696021-0	1998	Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice.	Phosphatidylcholines	90-109	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	44-48
9696021-1	1998	Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile.	Phosphatidylcholines	176-195	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	40-44
9784877-1	1998	The structural features of apolipoprotein A1 (apoA1) that provide for the formation of its stable micellar complexes with phosphatidylcholine are discussed.	Phosphatidylcholines	122-141	apolipoprotein A1	Homo sapiens	27-44
9784877-1	1998	The structural features of apolipoprotein A1 (apoA1) that provide for the formation of its stable micellar complexes with phosphatidylcholine are discussed.	Phosphatidylcholines	122-141	apolipoprotein A1	Homo sapiens	46-51
9784877-3	1998	The preparation procedures for discoidal micellar complexes of apoA1 with phosphatidylcholine are discussed, and the characteristics of the complexes are described.	Phosphatidylcholines	74-93	apolipoprotein A1	Homo sapiens	63-68
9683538-10	1998	Treatment of F3II cells, with phorbol myristate acetate (PMA) or phosphatidic acid (PA, the product of PLD-dependent hydrolysis of phosphatidylcholine), significantly enhanced CD44 expression.	Phosphatidylcholines	131-150	CD44 antigen	Mus musculus	176-180
9685717-0	1998	Reactivity of soybean lipoxygenase-1 to linoleic acid entrapped in phosphatidylcholine vesicles.	Phosphatidylcholines	67-86	seed linoleate 13S-lipoxygenase-1	Glycine max	22-36
9733153-7	1998	The intake of n-3 PUFA was checked by red blood cell (RBC) phosphatidylcholine (PC) fatty acid composition.	Phosphatidylcholines	59-78	pumilio RNA binding family member 3	Homo sapiens	18-22
9733153-7	1998	The intake of n-3 PUFA was checked by red blood cell (RBC) phosphatidylcholine (PC) fatty acid composition.	Phosphatidylcholines	80-83	pumilio RNA binding family member 3	Homo sapiens	18-22
9692961-1	1998	Bilayers composed of phosphatidylcholine initially resist catalysis by phospholipase A2.	Phosphatidylcholines	21-40	phospholipase A2 group IB	Homo sapiens	71-87
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	11-15
9668079-6	1998	Cells expressing the E161K mutation in the URA7-encoded CTP synthetase exhibited an increase (1.5-fold) in the utilization of the Kennedy pathway for phosphatidylcholine synthesis when compared with control cells.	Phosphatidylcholines	150-169	CTP synthase URA7	Saccharomyces cerevisiae S288C	43-47
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	17-21
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	27-31
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	107-112
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	169-173
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	189-193
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Phosphatidylcholines	64-83	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-8	1998	We also propose that phospholipase D1-mediated phosphatidylcholine turnover generates a signal that activates transcription of INO1, the structural gene for inositol 1-phosphate synthase.	Phosphatidylcholines	47-66	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	127-131
9688933-5	1998	A2R inhibited cell association of 125I-SP-A to type II cells plated on Transwell membranes as well as those plated on plastic dishes and also inhibited the SP-A-stimulated incorporation of phosphatidylcholine liposomes into type II cells.	Phosphatidylcholines	189-208	surfactant protein A1	Homo sapiens	156-160
9639664-3	1998	Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals.	Phosphatidylcholines	14-20	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	24-39
9681053-9	1998	The HPLAPs were selectively incorporated into liposomes consisting of phosphatidylcholine/cholesterol, and most of the PIPL-D-treated PLAP could from HPLAPs, while a small amount of PLAP could not form HPLAPs.	Phosphatidylcholines	70-89	alkaline phosphatase, placental	Homo sapiens	5-9
9681053-9	1998	The HPLAPs were selectively incorporated into liposomes consisting of phosphatidylcholine/cholesterol, and most of the PIPL-D-treated PLAP could from HPLAPs, while a small amount of PLAP could not form HPLAPs.	Phosphatidylcholines	70-89	alkaline phosphatase, placental	Homo sapiens	134-138
9639664-3	1998	Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals.	Phosphatidylcholines	14-20	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-44
9721630-1	1998	The interaction of the amphoteric surfactant N-dodecyl-N,N-dimethylbetaine (C12-Bet) with phosphatidylcholine (PC) liposomes was investigated.	Phosphatidylcholines	90-109	delta/notch like EGF repeat containing	Homo sapiens	80-83
9721630-1	1998	The interaction of the amphoteric surfactant N-dodecyl-N,N-dimethylbetaine (C12-Bet) with phosphatidylcholine (PC) liposomes was investigated.	Phosphatidylcholines	111-113	delta/notch like EGF repeat containing	Homo sapiens	80-83
9684747-2	1998	We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA.	Phosphatidylcholines	241-260	lecithin-cholesterol acyltransferase	Homo sapiens	75-111
9684747-2	1998	We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA.	Phosphatidylcholines	241-260	lecithin-cholesterol acyltransferase	Homo sapiens	113-117
9684747-2	1998	We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA.	Phosphatidylcholines	262-264	lecithin-cholesterol acyltransferase	Homo sapiens	75-111
9684747-2	1998	We tested the hypothesis that the decreased HDL is due to an inhibition of lecithin:cholesterol acyltransferase (LCAT), the enzyme essential for the formation of HDL, by determining the activity of purified LCAT in the presence of synthetic phosphatidylcholine (PC) substrates containing TUFA.	Phosphatidylcholines	262-264	lecithin-cholesterol acyltransferase	Homo sapiens	113-117
9684747-7	1998	Thus, for human LCAT, 18:1t was more inhibitory when present at sn-2 position of PC, than at sn-1, when paired with 16:0.	Phosphatidylcholines	81-83	lecithin-cholesterol acyltransferase	Homo sapiens	16-20
9748733-4	1998	The objective of the present study was to assess how the fatty acid composition in plasma phosphatidyl choline affects the total and LDL cholesterol, triglyceride and apolipoprotein B concentrations in subjects with primary hyperlipoproteinaemia and dyslipidaemia.	Phosphatidylcholines	90-110	apolipoprotein B	Homo sapiens	167-183
9649332-1	1998	Pulmonary surfactant-associated protein B (SP-B) has been isolated from porcine lungs and reconstituted in bilayers of dipalmitoylphosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) to characterize the extent of insertion of the protein into phospholipid bilayers.	Phosphatidylcholines	130-149	surfactant protein B	Homo sapiens	0-41
9649332-1	1998	Pulmonary surfactant-associated protein B (SP-B) has been isolated from porcine lungs and reconstituted in bilayers of dipalmitoylphosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) to characterize the extent of insertion of the protein into phospholipid bilayers.	Phosphatidylcholines	153-155	surfactant protein B	Homo sapiens	0-41
9748733-10	1998	CONCLUSIONS: The submitted results indicate that the fatty acid concentrations of PC in plasma are significantly and markedly correlated with concentrations of total cholesterol, triglycerides, LDL-cholesterol and apolipoprotein B.	Phosphatidylcholines	82-84	apolipoprotein B	Homo sapiens	214-230
9649332-2	1998	The parameters for the interaction of SP-B with DPPC or PC using different reconstitution protocols have been estimated from the changes induced in the fluorescence emission spectrum of the single protein tryptophan.	Phosphatidylcholines	50-52	surfactant protein B	Homo sapiens	38-42
9622488-2	1998	This facilitates lipase adsorption to phosphatidylcholine-rich interfaces, presumably as a consequence of the higher affinity of colipase for such interfaces.	Phosphatidylcholines	38-57	colipase	Homo sapiens	129-137
9649332-5	1998	SP-B tryptophan was found to be located 10-13 A from the center of bilayers, which is consistent with a superficial location of SP-B in phosphatidylcholine membranes.	Phosphatidylcholines	136-155	surfactant protein B	Homo sapiens	0-4
9649332-5	1998	SP-B tryptophan was found to be located 10-13 A from the center of bilayers, which is consistent with a superficial location of SP-B in phosphatidylcholine membranes.	Phosphatidylcholines	136-155	surfactant protein B	Homo sapiens	128-132
9636222-1	1998	Phosphatidylcholine-specific phospholipase C (PC-PLC) is a necessary intermediate in transducing apoptotic signals for tumor necrosis factor and Fas/Apo-1 ligands in nonneuronal cells.	Phosphatidylcholines	0-19	Fas cell surface death receptor	Homo sapiens	149-154
9630635-9	1998	The results indicate that TNF specifically modulates the kinetics of membrane-bound enzymes of the rate determining steps in phosphatidylcholine biosynthesis, possibly as part of early events involved in apoptosis.	Phosphatidylcholines	125-144	tumor necrosis factor	Homo sapiens	26-29
9622504-4	1998	The binding of cPLA2 to phosphatidylcholine vesicles is mostly governed by its C2 domain; binding is relatively weak, and calcium enhances binding and interfacial catalysis by about 10-fold.	Phosphatidylcholines	24-43	phospholipase A2 group IVA	Homo sapiens	15-20
9581864-1	1998	In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively.	Phosphatidylcholines	115-134	interleukin 6	Mus musculus	278-291
9601059-2	1998	Previously we showed that stimulation of phosphatidylcholine (PtdCho) synthesis by PMA in SK-N-MC human neuroblastoma cells required overexpression of MARCKS, whereas PKCalpha alone was insufficient.	Phosphatidylcholines	41-60	myristoylated alanine rich protein kinase C substrate	Homo sapiens	151-157
9601059-2	1998	Previously we showed that stimulation of phosphatidylcholine (PtdCho) synthesis by PMA in SK-N-MC human neuroblastoma cells required overexpression of MARCKS, whereas PKCalpha alone was insufficient.	Phosphatidylcholines	62-68	myristoylated alanine rich protein kinase C substrate	Homo sapiens	151-157
9601059-7	1998	The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD.	Phosphatidylcholines	62-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-43
9601059-7	1998	The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD.	Phosphatidylcholines	130-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-43
9601059-7	1998	The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD.	Phosphatidylcholines	130-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	201-204
9601059-10	1998	Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response.	Phosphatidylcholines	84-90	myristoylated alanine rich protein kinase C substrate	Homo sapiens	22-28
9601059-10	1998	Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response.	Phosphatidylcholines	84-90	protein kinase C alpha	Homo sapiens	57-60
9601059-10	1998	Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response.	Phosphatidylcholines	84-90	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	100-103
9787801-12	1998	These results indicate isolation from bovine lung of a 29 kDa acidic Ca(2+)-independent phospholipase A2 homologue of the rat and human enzyme and provide evidence for specificity in the metabolism of lung surfactant phosphatidylcholine.	Phosphatidylcholines	217-236	LOC104974671	Bos taurus	88-104
9572479-5	1998	Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling.	Phosphatidylcholines	23-42	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	72-78
9572479-5	1998	Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling.	Phosphatidylcholines	23-42	early growth response 1	Rattus norvegicus	83-88
9572479-5	1998	Instead, inhibition of phosphatidylcholine-specific PLC interfered with PGHS-2 and egr-1 mRNA induction, suggesting this enzyme as a link between 5-HT2A receptors and protein kinase C, an essential part of 5-HT-mediated signaling.	Phosphatidylcholines	23-42	5-hydroxytryptamine receptor 2A	Rattus norvegicus	146-152
9581864-1	1998	In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively.	Phosphatidylcholines	115-134	interleukin 6	Mus musculus	293-297
9643351-0	1998	Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2.	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	0-16
9626147-10	1998	Lyso PtdCho, a product derived from phospholipase A2 action on peroxidized phosphatidylcholine and a potent chemotactic factor for monocytes and T-lymphocytes, is elevated in endometriosis.	Phosphatidylcholines	75-94	phospholipase A2 group IB	Homo sapiens	36-52
9593849-0	1998	Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D.	Phosphatidylcholines	29-48	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	114-129
11324575-2	1998	The results showed that ET-1 (10(-12) and 10(-10) mol/L) increased the basal secretion of total phospholipids (TP) and phosphatidylcholine (PC), and potentiated the stimulatory effect of intermittent lung inflation on the secretion of TP and PC.	Phosphatidylcholines	140-142	endothelin 1	Rattus norvegicus	24-28
9593672-2	1998	Guinea pig intestinal phospholipase B is a calcium-independent phospholipase hydrolyzing sequentially the acyl ester bonds at sn-2 and sn-1 positions of glycerophospholipids, promoting the formation of sn-glycero-3-phosphocholine from phosphatidylcholine.	Phosphatidylcholines	235-254	phospholipase B1, membrane-associated	Cavia porcellus	22-37
9593849-4	1998	In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold).	Phosphatidylcholines	85-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
11324575-2	1998	The results showed that ET-1 (10(-12) and 10(-10) mol/L) increased the basal secretion of total phospholipids (TP) and phosphatidylcholine (PC), and potentiated the stimulatory effect of intermittent lung inflation on the secretion of TP and PC.	Phosphatidylcholines	119-138	endothelin 1	Rattus norvegicus	24-28
9593753-1	1998	CTP:phosphocholine cytidylyltransferase (CCT) is a key regulator of phosphatidylcholine biosynthesis, and only a single isoform of this enzyme, CCTalpha, is known.	Phosphatidylcholines	68-87	phosphate cytidylyltransferase 1A, choline	Homo sapiens	144-152
9593753-8	1998	Transfection of COS-7 cells with a CCTbeta expression construct led to the overexpression of CCT activity, the accumulation of cellular CDP-choline, and enhanced radiolabeling of phosphatidylcholine.	Phosphatidylcholines	179-198	phosphate cytidylyltransferase 1B, choline	Homo sapiens	35-42
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	154-173	protein kinase C alpha	Homo sapiens	22-25
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	154-173	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	154-173	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	175-181	protein kinase C alpha	Homo sapiens	22-25
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	175-181	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Phosphatidylcholines	175-181	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
9593849-2	1998	Here, attached and suspended NIH 3T3 fibroblasts as well as variants of the MCF-7 human breast carcinoma cell line expressing PKC-alpha and a PtdCho-specific PLD activity at widely different levels were used to determine the possible role of PKC-alpha, PtdCho hydrolysis, and choline uptake in the mediation of PMA effect on PtdCho synthesis.	Phosphatidylcholines	142-148	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	158-161
9585574-4	1998	In the present study, Fourier transform infrared spectroscopy (FTIR) has been used to monitor the hydrolysis of phosphatidylcholine by phospholipase A2 (PLA2) from Naja mocambique mocambique venom in the presence of various aminoglycosides and/or daptomycin.	Phosphatidylcholines	112-131	phospholipase A2 group IB	Homo sapiens	135-151
9648220-5	1998	This Amadori product formation was also confirmed in PE/phosphate buffer dispersions and in phosphatidylcholine-PE liposome/phosphate buffer suspensions in the presence of D-glucose at 37 degrees C. gPE was degraded by phospholipase A2, C and D.	Phosphatidylcholines	92-111	phospholipase A2 group IB	Homo sapiens	219-244
9585574-4	1998	In the present study, Fourier transform infrared spectroscopy (FTIR) has been used to monitor the hydrolysis of phosphatidylcholine by phospholipase A2 (PLA2) from Naja mocambique mocambique venom in the presence of various aminoglycosides and/or daptomycin.	Phosphatidylcholines	112-131	phospholipase A2 group IB	Homo sapiens	153-157
9575167-2	1998	The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer.	Phosphatidylcholines	81-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	26-41
9575167-2	1998	The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer.	Phosphatidylcholines	81-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-46
9560313-1	1998	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, generating phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
9648224-7	1998	iii) Oxidized phosphatidylcholine, but not oxidized cholesterol, in the vesicles affected LCAT activity.	Phosphatidylcholines	14-33	lecithin-cholesterol acyltransferase	Homo sapiens	90-94
9564846-4	1998	GLP-1(7-36)amide stimulated phosphatidylcholine secretion in a concentration-dependent manner in the 1-100 nM range; the concentration of the peptide that produced a half-maximal response was 10 nM.	Phosphatidylcholines	28-47	glucagon	Rattus norvegicus	0-5
9648224-9	1998	These results suggest that the esterification of cholesterol by LCAT may be affected by the oxidation of substrate phosphatidylcholine via free radical generation in the plasma.	Phosphatidylcholines	115-134	lecithin-cholesterol acyltransferase	Homo sapiens	64-68
9564846-8	1998	A study of the mechanism through which GLP-1-(7-36)amide exerts its stimulatory effect was carried out using different agents that are well known stimulants of phosphatidylcholine secretion.	Phosphatidylcholines	160-179	glucagon	Rattus norvegicus	39-44
9573065-3	1998	Incubation of isolated neutrophils with [3H]AA resulted in incorporation of radioactivity in the PLA2 substrates phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine.	Phosphatidylcholines	113-132	LOC104974671	Bos taurus	97-101
9596995-5	1998	In addition, we have found that D609, a specific inhibitor of phosphatidylcholine-specific phospholipase C, also inhibits IL-3-induced expression of the bcl-2 gene without affecting IL-3-induced tyrosine phosphorylation.	Phosphatidylcholines	62-81	interleukin 3	Homo sapiens	122-126
9596995-5	1998	In addition, we have found that D609, a specific inhibitor of phosphatidylcholine-specific phospholipase C, also inhibits IL-3-induced expression of the bcl-2 gene without affecting IL-3-induced tyrosine phosphorylation.	Phosphatidylcholines	62-81	BCL2 apoptosis regulator	Homo sapiens	153-158
9556620-7	1998	PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1.	Phosphatidylcholines	204-223	serpin family A member 5	Homo sapiens	0-3
9562607-1	1998	The interaction and orientation of a membrane protein ion channel model, an alpha-aminoisobutyric acid analogue of gramicidin B (GBA), in egg yolk phosphatidylcholine vesicles was studied by means of fluorescence spectroscopic techniques.	Phosphatidylcholines	147-166	glucosylceramidase beta	Homo sapiens	129-132
9585013-2	1998	PTHrP stimulates phosphatidylcholine synthesis in rat fetal lung explants, suggesting a role in fetal type II alveolar maturation and surfactant production.	Phosphatidylcholines	17-36	parathyroid hormone-like hormone	Rattus norvegicus	0-5
9643439-1	1998	The aim of this study was to investigate if the effective in-situ permeability (Peff) of a new growth hormone-releasing peptide, hexarelin, along rat intestine was enhanced by a lipid matrix drug-delivery system comprising a mixture of soybean phosphatidyl choline and medium-chain monoacylglycerol (PC-MG).	Phosphatidylcholines	244-264	ghrelin and obestatin prepropeptide	Rattus norvegicus	95-127
9610765-10	1998	Compared to eight normal fibroblast cell lines, homogenates and culture media of four TD fibroblast cell lines were reduced by 40-50% and 30-35%, respectively, in their activity to transfer PC, PI, or PE onto apoA-I.	Phosphatidylcholines	190-192	apolipoprotein A1	Homo sapiens	209-215
9535891-7	1998	APC and the chimera bound to phosphatidylserine:phosphatidylcholine vesicles with similar affinity (Kd approximately 500 nM), and PE increased affinity 2-3-fold.	Phosphatidylcholines	48-67	APC regulator of WNT signaling pathway	Homo sapiens	0-3
9848183-1	1998	Kinetics of methemoglobin structural changes in the complex with liposomes composed of phosphatidylcholine and its mixtures with cardiolipin has been studied.	Phosphatidylcholines	87-106	hemoglobin subunit gamma 2	Homo sapiens	12-25
9553075-11	1998	A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles.	Phosphatidylcholines	175-194	secretoglobin family 2B member 3, pseudogene	Homo sapiens	47-50
9553075-11	1998	A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles.	Phosphatidylcholines	175-194	rabphilin 3A	Homo sapiens	160-171
9531469-4	1998	First, hV-PLA2 can catalyse the hydrolysis of phosphatidylcholine more effectively than hIIa-PLA2 by two orders of magnitude.	Phosphatidylcholines	46-65	phospholipase A2 group V	Homo sapiens	7-14
9531469-4	1998	First, hV-PLA2 can catalyse the hydrolysis of phosphatidylcholine more effectively than hIIa-PLA2 by two orders of magnitude.	Phosphatidylcholines	46-65	phospholipase A2 group IB	Homo sapiens	10-14
9531469-5	1998	Secondly, hV-PLA2 has much higher binding affinity and activity for compactly packed phosphatidylcholine bilayers than hIIa-PLA2.	Phosphatidylcholines	85-104	phospholipase A2 group V	Homo sapiens	10-17
9531469-5	1998	Secondly, hV-PLA2 has much higher binding affinity and activity for compactly packed phosphatidylcholine bilayers than hIIa-PLA2.	Phosphatidylcholines	85-104	phospholipase A2 group IB	Homo sapiens	13-17
9538008-1	1998	Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified.	Phosphatidylcholines	31-50	phospholipase D1	Homo sapiens	83-86
9555096-7	1998	Hydrolysis of mixed vesicles containing phosphatidylserine and phosphatidylcholine by the venom and pancreatic enzymes were differentially inhibited by annexin V.	Phosphatidylcholines	63-82	annexin A5	Homo sapiens	152-161
9555096-9	1998	In contrast, the venom enzyme is able to readily hydrolyse phosphatidylcholine domains that would be minimally affected by annexin V.	Phosphatidylcholines	59-78	annexin A5	Homo sapiens	123-132
9555099-6	1998	After extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at 2490 cm-1 as a B-H band in the mixture of BSH with phosphatidylcholine, which is attributed to a BSH-phosphatidylcholine complex, which could dissolve well in CCl4.	Phosphatidylcholines	141-160	C-C motif chemokine ligand 4	Homo sapiens	44-48
9555099-6	1998	After extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at 2490 cm-1 as a B-H band in the mixture of BSH with phosphatidylcholine, which is attributed to a BSH-phosphatidylcholine complex, which could dissolve well in CCl4.	Phosphatidylcholines	141-160	C-C motif chemokine ligand 4	Homo sapiens	249-253
9555099-7	1998	The molar ratio of BSH to phosphatidylcholine in the CCl4 solution was at most one mole of BSH to two moles of phosphatidylcholine independent of the excess BSH.	Phosphatidylcholines	26-45	C-C motif chemokine ligand 4	Homo sapiens	53-57
9555099-7	1998	The molar ratio of BSH to phosphatidylcholine in the CCl4 solution was at most one mole of BSH to two moles of phosphatidylcholine independent of the excess BSH.	Phosphatidylcholines	111-130	C-C motif chemokine ligand 4	Homo sapiens	53-57
9538008-1	1998	Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified.	Phosphatidylcholines	31-50	phospholipase D1	Homo sapiens	89-93
9538008-1	1998	Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified.	Phosphatidylcholines	31-50	phospholipase D2	Homo sapiens	98-102
9556135-0	1998	Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C. We previously showed that prostaglandin E2 (PGE2) stimulates multiple intracellular signaling pathways as follows: by activation of adenylate cyclase; phosphoinositide (PI)-hydrolyzing phospholipase C and phosphatidylcholine (PC)-hydrolyzing phospholipase D; and by induction of Ca2+ influx in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	322-324	interleukin 6	Mus musculus	0-13
9555056-1	1998	Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma).	Phosphatidylcholines	0-19	fibroblast growth factor 2	Rattus norvegicus	47-77
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylcholines	135-154	mannose binding lectin 2	Homo sapiens	6-27
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylcholines	135-154	mannose binding lectin 2	Homo sapiens	29-32
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylcholines	156-158	mannose binding lectin 2	Homo sapiens	6-27
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylcholines	156-158	mannose binding lectin 2	Homo sapiens	29-32
9551426-4	1998	MDR2 Pgp is exclusively a phosphatidylcholine translocase.	Phosphatidylcholines	26-45	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
9551426-4	1998	MDR2 Pgp is exclusively a phosphatidylcholine translocase.	Phosphatidylcholines	26-45	phosphoglycolate phosphatase	Homo sapiens	5-8
9535751-2	1998	The PLD activity was measured by phosphatidylethanol produced from radiolabeled phosphatidylcholine or myristic acid in the presence of ethanol.	Phosphatidylcholines	80-99	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
9516439-7	1998	In membranes of HEK-293 cells pretreated with TcdB-1470 or TcsL, basal and stable GTP analog-stimulated PLD activities measured with exogenous phosphatidylcholine, in the presence or absence of phosphatidylinositol 4,5-bisphosphate, were not altered.	Phosphatidylcholines	143-162	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
9559647-1	1998	The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals.	Phosphatidylcholines	46-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-95
9559647-1	1998	The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals.	Phosphatidylcholines	46-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
9559647-1	1998	The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals.	Phosphatidylcholines	67-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-95
9559647-1	1998	The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals.	Phosphatidylcholines	67-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
9555056-1	1998	Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma).	Phosphatidylcholines	0-19	fibroblast growth factor 2	Rattus norvegicus	79-83
9555056-1	1998	Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma).	Phosphatidylcholines	21-23	fibroblast growth factor 2	Rattus norvegicus	47-77
9555056-1	1998	Phosphatidylcholine (PC) hydrolysis induced by basic fibroblast growth factor (bFGF) was studied in rat L6 myoblasts expressing the wild-type FGF receptor-1 (FGFR-1) or a mutant (Y766F) that is incapable of activating phospholipase C-gamma (PLCgamma).	Phosphatidylcholines	21-23	fibroblast growth factor 2	Rattus norvegicus	79-83
9497326-6	1998	Here we demonstrate that this reducing activity extended to hydroperoxides of phosphatidylcholine, was similar in HDL2 and HDL3, was independent of arylesterase and lecithin:cholesteryl acyltransferase activity, was unaffected by sulfhydryl reagents, and was expressed by reconstituted particles containing apoAI or apoAII only, as well as isolated human apoAI.	Phosphatidylcholines	78-97	apolipoprotein A2	Homo sapiens	316-322
9506985-1	1998	Lysophosphatidylcholine (lyso-PC) is a product of phosphatidylcholine hydrolysis by phospholipase A2 (PLA2) and is present in cell membranes, oxidized lipoproteins, and atherosclerotic tissues.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	84-100
9506985-1	1998	Lysophosphatidylcholine (lyso-PC) is a product of phosphatidylcholine hydrolysis by phospholipase A2 (PLA2) and is present in cell membranes, oxidized lipoproteins, and atherosclerotic tissues.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	102-106
9494101-6	1998	Like LDL-PLA2, HSD-PLA2 was able to hydrolyse oxidatively modified phosphatidylcholines when supplemented to human LDL prior to copper-stimulated oxidation.	Phosphatidylcholines	67-87	phospholipase A2 group VII	Homo sapiens	5-13
9494101-6	1998	Like LDL-PLA2, HSD-PLA2 was able to hydrolyse oxidatively modified phosphatidylcholines when supplemented to human LDL prior to copper-stimulated oxidation.	Phosphatidylcholines	67-87	platelet activating factor acetylhydrolase 2	Homo sapiens	15-23
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	Phosphatidylcholines	187-206	nuclear factor kappa B subunit 1	Homo sapiens	98-107
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	Phosphatidylcholines	187-206	tumor necrosis factor	Homo sapiens	135-144
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	Phosphatidylcholines	187-206	interleukin 1 beta	Homo sapiens	149-157
9497326-13	1998	We conclude that the oxidation of specific Met residues of apoAI and apoAII to Met(O) plays a significant role in the 2-electron reduction of hydroperoxides of cholesteryl esters and phosphatidylcholine associated with human HDL.	Phosphatidylcholines	183-202	apolipoprotein A2	Homo sapiens	69-75
9488694-8	1998	Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM.	Phosphatidylcholines	16-35	apolipoprotein E	Homo sapiens	72-76
9488694-8	1998	Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM.	Phosphatidylcholines	16-35	apolipoprotein E	Homo sapiens	131-135
9547904-3	1998	Its enzymatic properties are distinct from those of well characterized phospholipase A2 enzymes; by using a series of synthetic phosphatidylcholines, the enzyme cleaved oleic, linoleic, and arachidonic acids like phospholipase A2, and released palmitic and stearic acids like phospholipase A1.	Phosphatidylcholines	128-148	phospholipase A2 group IB	Rattus norvegicus	71-87
9518571-1	1998	The effect of methemoglobin on the structure of model membranes composed of phosphatidylcholine and diphosphatidylglycerol (18 : 1, mol : mol) was studied with the help of pH-indicator dye bromothymol blue.	Phosphatidylcholines	76-95	hemoglobin subunit gamma 2	Homo sapiens	14-27
9521652-1	1998	The interaction of tissue factor pathway inhibitor (TFPI), factor Xa, and TFPI-factor Xa complexes with negatively charged phospholipid membranes composed of 25 mol % phosphatidylserine and 75 mol % phosphatidylcholine was studied by ellipsometry.	Phosphatidylcholines	199-218	coagulation factor X	Homo sapiens	79-88
9547904-3	1998	Its enzymatic properties are distinct from those of well characterized phospholipase A2 enzymes; by using a series of synthetic phosphatidylcholines, the enzyme cleaved oleic, linoleic, and arachidonic acids like phospholipase A2, and released palmitic and stearic acids like phospholipase A1.	Phosphatidylcholines	128-148	phospholipase A2 group IB	Rattus norvegicus	213-229
9473293-7	1998	Mouse ACBP also inhibited microsomal phospholipid acyl chain remodeling of choline-containing phospholipids, phosphatidylcholine and sphingomyelin, by 50 and 64%, respectively.	Phosphatidylcholines	109-128	diazepam binding inhibitor	Mus musculus	6-10
9487137-0	1998	Cucumber root lipoxygenase can act on acyl groups in phosphatidylcholine.	Phosphatidylcholines	53-72	LOW QUALITY PROTEIN: linoleate 9S-lipoxygenase 6	Cucumis sativus	14-26
9477969-0	1998	Influence of annexin V on the structure and dynamics of phosphatidylcholine/phosphatidylserine bilayers: a fluorescence and NMR study.	Phosphatidylcholines	56-75	annexin A5	Homo sapiens	13-22
9507109-1	1998	Phosphatidyl-choline (PC) vesicles and normal cell membranes are resistant to hydrolysis by human group II secreted PLA2, an enzyme that can attain high concentrations in extracellular fluids during many inflammatory processes.	Phosphatidylcholines	0-20	phospholipase A2 group IIA	Homo sapiens	116-120
9507109-1	1998	Phosphatidyl-choline (PC) vesicles and normal cell membranes are resistant to hydrolysis by human group II secreted PLA2, an enzyme that can attain high concentrations in extracellular fluids during many inflammatory processes.	Phosphatidylcholines	22-24	phospholipase A2 group IIA	Homo sapiens	116-120
9487144-3	1998	We examined involvement of PLD and PKC in the hydrolysis and resynthesis of PtdCho and phosphatidylethanolamine stimulated by beta-TPA, bryostatin (a non-phorbol PKC activator) and oleic acid (18:1n-9) in the four cell lines.	Phosphatidylcholines	76-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
9487144-10	1998	Thus, activation of PLD hydrolysis preceding resynthesis is involved in the stimulatory effects of beta-TPA on PtdCho synthesis in some but not all of these neural derived cells.	Phosphatidylcholines	111-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-23
9475519-5	1998	The following signal transduction mechanisms, reported to be induced in other systems by IL-1 beta, were investigated in U373 cells: (1) activation of phosphatidylcholine-specific phospholipase C as assayed by incorporation of tritiated choline into cellular phospholipids, (2) production of diacylglycerol, a lipid second messenger, (3) activation of sphingomyelinase, and (4) activation of mitogen-activated protein kinase (MAPK).	Phosphatidylcholines	151-170	interleukin 1 beta	Homo sapiens	89-98
9533699-7	1998	The degree of orientational order dropped dramatically in the dipolyunsaturated species compared with the mixed-chain phosphatidylcholines, which contained a polyunsaturated sn-2 chain.	Phosphatidylcholines	118-138	solute carrier family 38 member 5	Homo sapiens	174-178
9533708-5	1998	The relatively low sensitivity of halothane quenching of Trp fluorescence to the concentration of phosphatidylcholine and detergent in the PMCA preparation concurs with the quenching resulting from anesthetic binding in the PMCA molecule.	Phosphatidylcholines	98-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	139-143
9569615-1	1998	Porcine pancreatic phospholipase A2 (PLA2) hydrolyses phosphatidylcholine when in the lamellar state as well as in the micellar state.	Phosphatidylcholines	54-73	phospholipase A2 group IB	Homo sapiens	19-35
9569615-1	1998	Porcine pancreatic phospholipase A2 (PLA2) hydrolyses phosphatidylcholine when in the lamellar state as well as in the micellar state.	Phosphatidylcholines	54-73	phospholipase A2 group IB	Homo sapiens	37-41
9430672-1	1998	Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol.	Phosphatidylcholines	0-20	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	216-223
9442060-2	1998	Specifically, the presence of 1 mol% PtdIns(4,5)P2 in phosphatidylcholine vesicles results in a 20-fold increase in the binding affinity of cPLA2.	Phosphatidylcholines	54-73	phospholipase A2 group IVA	Homo sapiens	140-145
9578154-4	1998	Furthermore, pretreatment with PKA activators prevented much of the AIF4(-)-induced loss of [3H]AA from phosphatidylcholine and phosphatidylethanolamine in prelabeled osteoblasts.	Phosphatidylcholines	104-123	itchy E3 ubiquitin protein ligase	Homo sapiens	68-72
9578155-7	1998	In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine.	Phosphatidylcholines	60-79	arginine vasopressin	Rattus norvegicus	3-6
9578155-7	1998	In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine.	Phosphatidylcholines	60-79	arginine vasopressin	Rattus norvegicus	144-147
9461221-1	1998	The yeast phosphatidylinositol-transfer protein (Sec14) catalyses exchange of phosphatidylinositol and phosphatidylcholine between membrane bilayers in vitro.	Phosphatidylcholines	103-122	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	49-54
9430672-1	1998	Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol.	Phosphatidylcholines	0-20	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	225-232
9430672-1	1998	Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol.	Phosphatidylcholines	22-25	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	216-223
9430672-1	1998	Phosphatidylcholines (PCs) with branched fatty acyl chains substituted in the two positions of the main chains (branched PCs) have been shown to be potent activators of the side chain cleavage activity of cytochrome P450SCC (CYP11A1) (Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., and Schmid, R. D. (1996) J. Biol.	Phosphatidylcholines	22-25	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	225-232
9430672-9	1998	The data suggest that different properties of P450SCC in membrane systems including cholesterol binding, membrane integration, and protein exchange are affected by branched PCs and probably by other phospholipids, too, and therefore must be considered in an explanation of the observed high stimulation of activity.	Phosphatidylcholines	173-176	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	46-53
19570017-6	1998	Administration of insulin entrapped in positively charged liposomes composed of egg phosphatidylcholine with cholesterol and stearylamine (10: 2:1, in weight ratio) to normal rabbits produced substantial reduction in blood glucose concentration 90-120 min after the instillation of the formulation.	Phosphatidylcholines	84-103	insulin	Oryctolagus cuniculus	18-25
9526092-2	1998	LPC is produced as a result of PC hydrolysis by several isoforms of phospholipase A2 (PLA2) and in the reaction mediated by lecithin-cholesterol acyltransferase that transfers the fatty acid residue from PC to cholesterol.	Phosphatidylcholines	1-3	phospholipase A2 group IB	Homo sapiens	68-84
9526092-2	1998	LPC is produced as a result of PC hydrolysis by several isoforms of phospholipase A2 (PLA2) and in the reaction mediated by lecithin-cholesterol acyltransferase that transfers the fatty acid residue from PC to cholesterol.	Phosphatidylcholines	1-3	phospholipase A2 group IB	Homo sapiens	86-90
10347747-5	1998	Addition of 0.075% egg phosphatidylcholine (PC) to the four different solubilized rhodopsin samples significantly enhanced light-stimulated GTP hydrolysis by transducin, with initial rates increasing from 0 to 1, 1 to 2, and 5 to 30 pmol of Pi released/min/pmol of rhodopsin, respectively.	Phosphatidylcholines	44-46	rhodopsin	Homo sapiens	82-91
10347747-5	1998	Addition of 0.075% egg phosphatidylcholine (PC) to the four different solubilized rhodopsin samples significantly enhanced light-stimulated GTP hydrolysis by transducin, with initial rates increasing from 0 to 1, 1 to 2, and 5 to 30 pmol of Pi released/min/pmol of rhodopsin, respectively.	Phosphatidylcholines	44-46	rhodopsin	Homo sapiens	265-274
9448723-2	1998	Treatment of cells with Naja mocambique mocambique phospholipase A2 reduced the pool sizes of phosphatidylcholine and phosphatidylethanolamine compared with controls.	Phosphatidylcholines	94-113	phospholipase A2 group IB	Rattus norvegicus	51-67
9425156-1	1998	Phospholipase D (PLD) enzymes catalyze the hydrolysis of phosphatidylcholine and are involved in membrane trafficking and cytoskeletal reorganization.	Phosphatidylcholines	57-76	phospholipase D	Saccharomyces cerevisiae S288C	0-15
9425156-1	1998	Phospholipase D (PLD) enzymes catalyze the hydrolysis of phosphatidylcholine and are involved in membrane trafficking and cytoskeletal reorganization.	Phosphatidylcholines	57-76	phospholipase D	Saccharomyces cerevisiae S288C	17-20
9419367-1	1998	Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.	Phosphatidylcholines	120-139	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	61-65
9419367-1	1998	Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.	Phosphatidylcholines	120-139	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	78-82
9503164-1	1998	We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles.	Phosphatidylcholines	124-143	angiotensinogen	Homo sapiens	31-46
9503164-1	1998	We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles.	Phosphatidylcholines	124-143	angiotensinogen	Homo sapiens	69-74
9503164-1	1998	We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles.	Phosphatidylcholines	124-143	angiotensinogen	Homo sapiens	81-95
9503164-1	1998	We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles.	Phosphatidylcholines	124-143	angiotensinogen	Homo sapiens	97-103
9580032-1	1998	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
9463889-8	1998	Incorporation of phosphatidylethanolamine or phosphatidylserine into phosphatidylcholine vesicles reduced the binding of PDC-109, suggesting that both the density of phosphorylcholine groups and the surface charge determine the interaction of the seminal plasma protein with the surface of the membrane.	Phosphatidylcholines	69-88	seminal plasma protein PDC-109	Bos taurus	121-128
9463889-9	1998	Electron spin resonance measurements showed that binding of PDC-109 to phosphatidylcholine vesicles caused a rigidification of the membrane.	Phosphatidylcholines	71-90	seminal plasma protein PDC-109	Bos taurus	60-67
9436177-2	1998	The present study was performed to examine more fully the developmental biology of the effects of SP-A on phosphatidylcholine (PC) uptake, to determine the effect of SP-A on the cellular location of bound and internalized phospholipid and on the metabolism of internalized phospholipid by morphologically undifferentiated (18-day) and morphologically differentiated (19-day) fetal type II cells.	Phosphatidylcholines	106-125	surfactant protein A1	Rattus norvegicus	98-102
9436177-2	1998	The present study was performed to examine more fully the developmental biology of the effects of SP-A on phosphatidylcholine (PC) uptake, to determine the effect of SP-A on the cellular location of bound and internalized phospholipid and on the metabolism of internalized phospholipid by morphologically undifferentiated (18-day) and morphologically differentiated (19-day) fetal type II cells.	Phosphatidylcholines	127-129	surfactant protein A1	Rattus norvegicus	98-102
9580032-1	1998	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
9752720-8	1998	Similarities in the role of phospholipase D-mediated phosphatidylcholine turnover in the secretory process in yeast and mammals lend further credence to yeast as a model system.	Phosphatidylcholines	53-72	phospholipase D	Saccharomyces cerevisiae S288C	28-43
9405398-3	1997	Incubation of p37 with phosphatidylcholine labeled in the fatty acyl side chains resulted in the production of multiple lipid products that were identified by thin layer chromatography and mass spectrometry as diacylglycerol, free fatty acid, monoacylglycerol, and lysophosphatidylcholine.	Phosphatidylcholines	23-42	nucleoporin 37	Homo sapiens	14-17
9407098-4	1997	Unlike recombinant retinol dehydrogenase isozymes, recombinant CRAD was inhibited by 4-methylpyrazole, was not stimulated by ethanol, and did not require phosphatidylcholine for optimal activity.	Phosphatidylcholines	154-173	retinol dehydrogenase 16	Mus musculus	63-67
9405440-7	1997	Moreover, this GST-Nedd4-C2 domain was able to mediate Ca2+-dependent interactions with phosphatidylserine, phosphatidylinositol, and phosphatidylcholine liposomes in vitro.	Phosphatidylcholines	134-153	NEDD4 E3 ubiquitin protein ligase	Canis lupus familiaris	19-24
9393676-10	1997	We present strong evidence for a stimulation of hydrolysis of phosphatidyl-choline by human non-pancreatic sPLA2 in the presence of as little as 1 mol% phosphatidyl-methanol (&lt;40 fold total rate enhancement).	Phosphatidylcholines	62-82	phospholipase A2 group X	Homo sapiens	107-112
9437199-6	1997	As PAF:acetylhydrolase inactivates PAF and oxidized forms of phosphatidylcholine, we evaluated the relationship of lipoprotein-associated PAF:acetylhydrolase to PAF formation.	Phosphatidylcholines	61-80	phospholipase A2 group VII	Homo sapiens	3-22
9403543-11	1997	Zinc-protoporphyrin type IX, an inhibitor of heme oxygenase, and all 3 antioxidants, which inhibited CO production, also antagonized the TNF-alpha effect on cGMP and phosphatidylcholine synthesis.	Phosphatidylcholines	166-185	tumor necrosis factor	Homo sapiens	137-146
9437199-6	1997	As PAF:acetylhydrolase inactivates PAF and oxidized forms of phosphatidylcholine, we evaluated the relationship of lipoprotein-associated PAF:acetylhydrolase to PAF formation.	Phosphatidylcholines	61-80	PCNA clamp associated factor	Homo sapiens	3-6
9472552-1	1997	We have redesigned cationic liposomes by using a combination of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol to enhance the in vitro and in vivo effectiveness of antisense raf oligodeoxyribonucleotide (ODN).	Phosphatidylcholines	102-121	zinc fingers and homeoboxes 2	Homo sapiens	201-204
9394256-1	1997	Calcitonin-loading was studied in liposomes composed of phosphatidylcholine, cholesterol and stearylamine in relation to the vesicle preparation method.	Phosphatidylcholines	56-75	calcitonin related polypeptide alpha	Homo sapiens	0-10
9398170-7	1997	Here is reported the analysis in the other limit, PLA2-catalyzed hydrolysis of zwitterionic micelles of short-chain phosphatidylcholines, at which substrate and products are in rapid exchange.	Phosphatidylcholines	116-136	phospholipase A2, major isoenzyme	Sus scrofa	50-54
9371769-2	1997	Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	42-61	phosphatidylethanolamine N-methyltransferase	Mus musculus	126-170
9371769-2	1997	Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	42-61	phosphatidylethanolamine N-methyltransferase	Mus musculus	172-176
9371769-10	1997	This experiment also demonstrated that the choline moiety derived from PEMT in the liver can be distributed via the plasma throughout the mouse where it is found as phosphatidylcholine, lysophosphatidylcholine, and sphingomyelin.	Phosphatidylcholines	165-184	phosphatidylethanolamine N-methyltransferase	Mus musculus	71-75
9360946-7	1997	Our results also indicate that Galpha12QL-Ras stimulation of Na+/H+ exchange involves a D609-sensitive phospholipase and protein kinase C. These studies, for the first time, describe a novel Galpha12-specific signaling pathway involving Ras, phosphatidylcholine hydrolysis, and protein kinase C in the regulation of Na+/H+ exchange.	Phosphatidylcholines	242-261	G protein subunit alpha 12	Homo sapiens	31-41
9360946-7	1997	Our results also indicate that Galpha12QL-Ras stimulation of Na+/H+ exchange involves a D609-sensitive phospholipase and protein kinase C. These studies, for the first time, describe a novel Galpha12-specific signaling pathway involving Ras, phosphatidylcholine hydrolysis, and protein kinase C in the regulation of Na+/H+ exchange.	Phosphatidylcholines	242-261	G protein subunit alpha 12	Homo sapiens	31-39
9428661-0	1997	Characterization and optimization of phospholipase A2 catalyzed synthesis of phosphatidylcholine.	Phosphatidylcholines	77-96	phospholipase A2 group IB	Homo sapiens	37-53
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Phosphatidylcholines	66-85	phospholipase A2 group IB	Homo sapiens	4-20
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Phosphatidylcholines	66-85	phospholipase A2 group IB	Homo sapiens	22-26
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Phosphatidylcholines	87-89	phospholipase A2 group IB	Homo sapiens	4-20
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Phosphatidylcholines	87-89	phospholipase A2 group IB	Homo sapiens	22-26
9344462-2	1997	In contrast, stimulation of phosphatidylcholine synthesis by PKC activators, known to be mediated by PKC-alpha, is widespread in mammalian cells.	Phosphatidylcholines	28-47	protein kinase C alpha	Homo sapiens	61-64
9344462-2	1997	In contrast, stimulation of phosphatidylcholine synthesis by PKC activators, known to be mediated by PKC-alpha, is widespread in mammalian cells.	Phosphatidylcholines	28-47	protein kinase C alpha	Homo sapiens	101-110
9359829-15	1997	The binding of Go alpha and mutants translated in vitro to liposomes indicates that Go alpha preferentially binds to neutral phospholipids (phosphatidylcholine).	Phosphatidylcholines	140-159	tripartite motif containing 47	Homo sapiens	15-23
9359829-15	1997	The binding of Go alpha and mutants translated in vitro to liposomes indicates that Go alpha preferentially binds to neutral phospholipids (phosphatidylcholine).	Phosphatidylcholines	140-159	tripartite motif containing 47	Homo sapiens	84-92
9370429-1	1997	In reconstituted high-density lipoproteins, apolipoprotein A-I and phosphatidylcholines combine to form disks in which the amphipathic alpha-helices of apolipoprotein A-1 bind to the edge of a lipid bilayer core, shielding the hydrophic lipid tails from the aqueous environment.	Phosphatidylcholines	67-87	apolipoprotein A1	Homo sapiens	152-170
9379026-5	1997	We hereby identify two independent mechanisms of CD5-mediated diacylglycerol release by virtue of their different kinetics: 1) an early and transient diacylglycerol increase that results from the activation of a phosphatidylcholine-specific phospholipase C, and 2) a late and sustained increase that requires de novo phospholipid synthesis.	Phosphatidylcholines	212-231	CD5 molecule	Homo sapiens	49-52
9379026-6	1997	Studies performed on a TCR/CD3-deficient Jurkat cell variant indicate that only the CD5-mediated phosphatidylcholine-specific phospholipase C activation is dependent on TCR/CD3 expression.	Phosphatidylcholines	97-116	CD5 molecule	Homo sapiens	84-87
9394256-4	1997	Interactions of calcitonin with the liposomal membranes were evaluated by studying the fixation of radiolabelled calcitonin to the outer surface of empty liposomes, and by preparing calcitonin-loaded LDL-like nanoparticles composed of phosphatidylcholine and cholesteryloleate.	Phosphatidylcholines	235-254	calcitonin related polypeptide alpha	Homo sapiens	16-26
9405162-1	1997	Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD).	Phosphatidylcholines	61-80	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	106-121
9366248-2	1997	When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed.	Phosphatidylcholines	158-177	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
9405162-1	1997	Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD).	Phosphatidylcholines	61-80	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	123-126
9408022-10	1997	Thus, the platelet inhibitory activity of LM-PLA2 was shown to be dependent on the hydrolysis of plasma phospholipids and/or lipoproteins, most probably those rich in phosphatidylcholine.	Phosphatidylcholines	167-186	phospholipase A2, group V	Mus musculus	45-49
9366248-2	1997	When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed.	Phosphatidylcholines	179-181	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylcholines	41-60	phospholipase C beta 1	Homo sapiens	110-119
9334202-9	1997	Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation.	Phosphatidylcholines	215-234	phospholipase C beta 1	Homo sapiens	61-106
9334202-9	1997	Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation.	Phosphatidylcholines	215-234	phospholipase C beta 1	Homo sapiens	108-114
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylcholines	41-60	phospholipase C beta 2	Homo sapiens	124-133
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylcholines	160-179	phospholipase C beta 1	Homo sapiens	110-119
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylcholines	160-179	phospholipase C beta 2	Homo sapiens	124-133
9312108-4	1997	FRET was observed when Fl-FPR-APC was titrated in the presence of Ca2+ ions with phosphatidylcholine/phosphatidylserine (4:1) vesicles containing the FRET acceptor, octadecylrhodamine (OR).	Phosphatidylcholines	81-100	APC regulator of WNT signaling pathway	Homo sapiens	30-33
9355744-1	1997	Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution.	Phosphatidylcholines	100-119	surfactant protein B	Homo sapiens	0-41
9315860-0	1997	Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein.	Phosphatidylcholines	14-33	lipase C, hepatic type	Homo sapiens	37-51
9315860-1	1997	Hepatic lipase (HL) hydrolysis of phosphatidylcholine (PC) was studied in recombinant high-density lipoprotein particles (r-HDL).	Phosphatidylcholines	34-53	lipase C, hepatic type	Homo sapiens	0-14
9315860-1	1997	Hepatic lipase (HL) hydrolysis of phosphatidylcholine (PC) was studied in recombinant high-density lipoprotein particles (r-HDL).	Phosphatidylcholines	55-57	lipase C, hepatic type	Homo sapiens	0-14
9315860-10	1997	The hydrolysis of different species of PC [dipalmitoyl (DPPC), dioleoyl(DOPC), palmitoylarachidonoyl (PAPC), and palmitoyloleoyl (POPC)] in r-HDL was also investigated.	Phosphatidylcholines	39-41	protocadherin 8	Homo sapiens	102-106
9312119-0	1997	Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. We investigated the mechanism of interleukin-6 (IL-6) synthesis induced by tumor necrosis factor-alpha (TNF) in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	142-161	tumor necrosis factor	Mus musculus	0-27
9312119-8	1997	D-609, an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed the TNF-induced diacylglycerol production.	Phosphatidylcholines	23-42	tumor necrosis factor	Mus musculus	84-87
9312119-13	1997	These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for TNF-induced IL-6 synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells.	Phosphatidylcholines	189-208	tumor necrosis factor	Mus musculus	130-133
9312119-13	1997	These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for TNF-induced IL-6 synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells.	Phosphatidylcholines	189-208	interleukin 6	Mus musculus	148-152
9355744-0	1997	Different modes of interaction of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers.	Phosphatidylcholines	71-90	surfactant protein B	Homo sapiens	63-67
9355744-1	1997	Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution.	Phosphatidylcholines	100-119	surfactant protein B	Homo sapiens	43-47
9355744-1	1997	Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution.	Phosphatidylcholines	123-125	surfactant protein B	Homo sapiens	0-41
9355744-1	1997	Pulmonary surfactant-associated protein B (SP-B) has been incorporated into vesicles of dipalmitoyl phosphatidylcholine (DPPC) or egg yolk phosphatidylcholine (PC) by two different procedures to characterize the dependence of lipid-protein interactions on the method of reconstitution.	Phosphatidylcholines	123-125	surfactant protein B	Homo sapiens	43-47
9355744-4	1997	Both methods of reconstitution led to the extensive interaction of SP-B with PC bilayers as demonstrated by co-migration during centrifugation, marked protection against proteolysis, change in the fluorescence emission intensity of SP-B, and protection of SP-B tryptophan fluorescence from quenching by acrylamide.	Phosphatidylcholines	77-79	surfactant protein B	Homo sapiens	67-71
9355744-7	1997	Electron microscopy showed that the injection of SP-B into an aqueous phase containing PC or DPPC vesicles (method A) induced a rapid aggregation of vesicles.	Phosphatidylcholines	87-89	surfactant protein B	Homo sapiens	49-53
9307024-1	1997	Activation of phosphatidylcholine-specific phospholipase D(PLD) occurs as part of the complex signal-transduction cascade initiated by agonist stimulation of tyrosine kinase and G-protein-coupled receptors.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	59-62
9328844-7	1997	D-609, an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed the IL-1-induced diacylglycerol production.	Phosphatidylcholines	23-42	interleukin 1 complex	Mus musculus	84-88
9328844-9	1997	These results indicate that IL-1 activates PKC via phosphatidylcholine-specific phospholipase C in osteoblast-like cells, and the PKC activation then limits IL-6 synthesis induced by IL-1 itself.	Phosphatidylcholines	51-70	interleukin 1 complex	Mus musculus	28-32
9328844-9	1997	These results indicate that IL-1 activates PKC via phosphatidylcholine-specific phospholipase C in osteoblast-like cells, and the PKC activation then limits IL-6 synthesis induced by IL-1 itself.	Phosphatidylcholines	51-70	interleukin 1 complex	Mus musculus	183-187
9326304-3	1997	The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40).	Phosphatidylcholines	95-114	amyloid beta precursor protein	Homo sapiens	134-140
9326304-3	1997	The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40).	Phosphatidylcholines	116-118	amyloid beta precursor protein	Homo sapiens	134-140
9326304-3	1997	The purpose of the experiments reported here was to determine if cholesterol, fatty acids, and phosphatidylcholine (PC) would bind to A beta(1-40) and if such binding would be dependent on aggregation of A beta(1-40).	Phosphatidylcholines	116-118	amyloid beta precursor protein	Homo sapiens	204-210
9299527-1	1997	Synthetic melittin inhibited the enzymatic activity of secretory phospholipase A2 (PLA2) from various sources, including bee and snake venoms, bovine pancreas, and synovial fluid from rheumatoid arthritis patients, irrespective of substrate (e.g., [14C]-phosphatidylcholine or phosphatidylethanolamine vesicles and [3H]-oleic acid-labeled E.coli).	Phosphatidylcholines	254-273	phospholipase A2 group IIA	Homo sapiens	83-87
9468621-5	1997	It has been reported in particular that expression of the human MDR3 and mouse mdr2 genes promote translocation of long chain phosphatidylcholine, while expression of the MDR1 gene stimulates the outward motion of phospholipids possessing at least one short chain.	Phosphatidylcholines	126-145	ATP binding cassette subfamily B member 4	Homo sapiens	64-68
9468621-5	1997	It has been reported in particular that expression of the human MDR3 and mouse mdr2 genes promote translocation of long chain phosphatidylcholine, while expression of the MDR1 gene stimulates the outward motion of phospholipids possessing at least one short chain.	Phosphatidylcholines	126-145	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	79-83
9321809-0	1997	Complexes of apoA-1 with phosphatidylcholine suppress dysregulation of arterial tone by oxidized LDL.	Phosphatidylcholines	25-44	apolipoprotein A1	Homo sapiens	13-19
9278459-3	1997	In the present study, we show that MAP1B purified from young rat brain can bind to acidic phospholipids, such as phosphatidylserine, but not to a neutral phospholipid, phosphatidylcholine.	Phosphatidylcholines	168-187	microtubule-associated protein 1B	Rattus norvegicus	35-40
9370319-1	1997	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis.	Phosphatidylcholines	107-126	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
9370319-1	1997	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis.	Phosphatidylcholines	107-126	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	41-44
9370319-1	1997	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis.	Phosphatidylcholines	107-126	cut-like homeobox 1	Rattus norvegicus	73-76
9370322-8	1997	Significant differences exist in the behavior of the cholinephosphotransferase activities responsible for the synthesis of PAF and phosphatidylcholine.	Phosphatidylcholines	131-150	PCNA clamp associated factor	Homo sapiens	123-126
9370325-8	1997	Like the mammalian PEMT gene products, the S. cerevisiae class I enzyme can catalyze all three methylation steps to PC biosynthesis.	Phosphatidylcholines	116-118	phosphatidylethanolamine N-methyltransferase	Homo sapiens	19-23
9370326-1	1997	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	89-108	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	0-44
9370326-1	1997	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	89-108	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	46-50
9370326-7	1997	Deletion of the PEMT gene eliminates all activity in liver that converts phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	101-120	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	16-20
9370326-10	1997	There is reciprocal regulation of the Kennedy pathway for phosphatidylcholine biosynthesis (via CDP-choline) and phosphatidylethanolamine N-methyltransferase.	Phosphatidylcholines	58-77	cut-like homeobox 1	Rattus norvegicus	96-99
9370326-10	1997	There is reciprocal regulation of the Kennedy pathway for phosphatidylcholine biosynthesis (via CDP-choline) and phosphatidylethanolamine N-methyltransferase.	Phosphatidylcholines	58-77	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	113-157
9281306-0	1997	Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts.	Phosphatidylcholines	51-70	coagulation factor II	Mus musculus	0-8
9281306-0	1997	Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts.	Phosphatidylcholines	51-70	interleukin 6	Mus musculus	19-32
9281306-1	1997	We previously reported that thrombin stimulates Ca2+ influx and activates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	74-93	coagulation factor II	Mus musculus	28-36
9294443-11	1997	In yeast, phosphatidylcholine (PC) biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol.	Phosphatidylcholines	10-29	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	133-137
9294443-11	1997	In yeast, phosphatidylcholine (PC) biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol.	Phosphatidylcholines	31-33	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	133-137
9323586-4	1997	The SM content of microsomes from NADe-fed rats was about one-third lower than for the control, and phosphatidylcholine (PC) was reduced by &lt; 10%; there was also a small decrease in PC, but not SM, in plasma membranes.	Phosphatidylcholines	121-123	brain expressed X-linked 3	Rattus norvegicus	34-38
9266766-6	1997	An ensuing generation of lysoPC and arachidonic acid, which paralleled the occurrence of exocytosis, revealed that the newly synthesized PC was hydrolyzed by phospholipase A2.	Phosphatidylcholines	29-31	phospholipase A2 group IB	Homo sapiens	158-174
9307942-0	1997	Preparation of Schiff base adducts of phosphatidylcholine core aldehydes and aminophospholipids, amino acids, and myoglobin.	Phosphatidylcholines	38-57	myoglobin	Homo sapiens	114-123
9252414-7	1997	Misregulation of the INO1 gene has been observed in many strains with altered phospholipid metabolism, and the relationship between phosphatidylcholine turnover and regulation of INO1 and other co-regulated genes of phospholipid biosynthesis is discussed.	Phosphatidylcholines	132-151	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	179-183
9252414-0	1997	Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation.	Phosphatidylcholines	39-58	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	77-83
9252414-0	1997	Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation.	Phosphatidylcholines	39-58	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	121-125
9305796-6	1997	We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG).	Phosphatidylcholines	62-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-106
9305796-6	1997	We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG).	Phosphatidylcholines	62-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
9254602-0	1997	Lateral packing of the pancreatic lipase cofactor, colipase, with phosphatidylcholine and substrates.	Phosphatidylcholines	66-85	colipase	Homo sapiens	51-59
9254602-6	1997	Phosphatidylcholine, diacylglycerols, and free fatty acid remain in the monolayer phase up to &lt;/=25 lipid chain:colipase ratios.	Phosphatidylcholines	0-19	colipase	Homo sapiens	115-123
9254602-11	1997	Phosphatidylcholine also remains in the interface at lipid chain:colipase ratios &gt;3 but shows little additional interaction with colipase.	Phosphatidylcholines	0-19	colipase	Homo sapiens	65-73
9295162-1	1997	Phosphatidylcholine is the major phospholipid in mammalian tissues and the biosynthesis of phosphatidylcholine in H9c2 cells was previously shown to be stimulated by angiotensin II.	Phosphatidylcholines	0-19	angiotensinogen	Rattus norvegicus	166-180
9295162-1	1997	Phosphatidylcholine is the major phospholipid in mammalian tissues and the biosynthesis of phosphatidylcholine in H9c2 cells was previously shown to be stimulated by angiotensin II.	Phosphatidylcholines	91-110	angiotensinogen	Rattus norvegicus	166-180
9295162-2	1997	In this study, we used the potent AT1 receptor antagonist, losartan, to determine if the angiotensin II-mediated stimulation of phosphatidylcholine biosynthesis was mediated by AT1 receptors.	Phosphatidylcholines	128-147	angiotensinogen	Rattus norvegicus	89-103
9295162-8	1997	High concentrations of losartan caused a translocation of CTP:phosphocholine cytidylyltransferase from the cytosolic (inactive) to the membrane (active) fraction likely as a compensatory mechanism for the losartan-mediated reduction in new phosphatidylcholine biosynthesis.	Phosphatidylcholines	240-259	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	58-97
9295162-10	1997	The results suggest that angiotensin II stimulates phosphatidylcholine biosynthesis independent of AT1- and AT2-receptor activation and losartan inhibits phosphatidylcholine biosynthesis by reducing choline uptake in H9c2 cells.	Phosphatidylcholines	51-70	angiotensinogen	Rattus norvegicus	25-39
9252414-1	1997	In yeast, mutations in the CDP-choline pathway for phosphatidylcholine biosynthesis permit the cell to grow even when the SEC14 gene is completely deleted (Cleves, A., McGee, T., Whitters, E., Champion, K., Aitken, J., Dowhan, W., Goebl, M., and Bankaitis, V. (1991) Cell 64, 789-800).	Phosphatidylcholines	51-70	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	122-127
9252414-2	1997	We report that strains carrying mutations in the CDP-choline pathway, such as cki1, exhibit a choline excretion phenotype due to production of choline during normal turnover of phosphatidylcholine.	Phosphatidylcholines	177-196	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	78-82
9252414-4	1997	We show that the increased choline excretion in sec14(ts) cki1 cells is due to increased turnover of phosphatidylcholine via a mechanism consistent with phospholipase D-mediated turnover.	Phosphatidylcholines	101-120	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	48-53
9252414-4	1997	We show that the increased choline excretion in sec14(ts) cki1 cells is due to increased turnover of phosphatidylcholine via a mechanism consistent with phospholipase D-mediated turnover.	Phosphatidylcholines	101-120	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	58-62
9267689-1	1997	We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	59-78	endothelin 1	Mus musculus	28-40
9252414-5	1997	We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated.	Phosphatidylcholines	37-56	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	69-74
9252414-5	1997	We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated.	Phosphatidylcholines	37-56	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	79-83
9252414-5	1997	We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated.	Phosphatidylcholines	37-56	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	175-181
9252414-6	1997	As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-).	Phosphatidylcholines	3-22	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	45-50
9252414-6	1997	As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-).	Phosphatidylcholines	3-22	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	55-59
9252414-6	1997	As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-).	Phosphatidylcholines	3-22	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	110-114
9271075-1	1997	Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	59-78	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
9271075-1	1997	Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	59-78	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
9267689-1	1997	We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	59-78	endothelin 1	Mus musculus	42-46
9267689-7	1997	The results strongly suggest that ETA receptor mediates the three intracellular signaling pathways of ET-1: (1) phosphoinositide hydrolysis by phospholipase C; (2) phosphatidylcholine hydrolysis by phospholipase D; (3) arachidonic acid release in osteoblast-like cells.	Phosphatidylcholines	164-183	endothelin 1	Mus musculus	102-106
9360016-4	1997	The activity of delta 5-desaturase was higher in the upper than in the lower portions of the villus, and was greater in P than in S. The activity of delta 9- and delta 6-desaturases did not vary along the villus or with changes in dietary S or P. The two predominant EMM phospholipids were phosphatidylcholine and phosphatidylethanolamine, and these did not vary along the villus or with changes in diet.	Phosphatidylcholines	290-309	fatty acid desaturase 1	Rattus norvegicus	16-34
9224204-6	1997	Through the use of specific inhibitors, we demonstrate that phosphatidylcholine (PC)-specific phospholipase C (PLC) and protein kinase C (PKC) are involved in mediating the elastin message stabilization.	Phosphatidylcholines	60-79	elastin	Homo sapiens	173-180
9260748-7	1997	The phospholipid asymmetry of NF1T plasma membrane followed the general features of phospholipid asymmetry in eukaryotic cells: sphingomyelin and phosphatidylcholine were preferentially located in the outer leaflet (90% and 89%, respectively) while the aminophospholipids phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol were in the inner half of the membrane (85%, 96%, and 69%, respectively).	Phosphatidylcholines	146-165	neurofibromin 1	Homo sapiens	30-33
9256237-2	1997	The nociceptin receptor-mediated MAPK activation was partially blocked by down-regulation or inhibition of protein kinase C, and suppressed by pretreatment with a phosphatidylcholine-specific phospholipase C inhibitor, D609.	Phosphatidylcholines	163-182	nociceptin receptor	Cricetulus griseus	4-23
9211897-3	1997	HDL and dimyristoyl phosphatidylcholine binding assays using the variant apoA-I forms have shown that replacement of specific carboxyl-terminal hydrophobic residues Leu222, Phe225, and Phe229 with lysines, as well as replacement of Leu211, Leu214, Leu218, and Leu219 with valines, diminished the ability of apoA-I to bind to HDL and to lyse dimyristoyl phosphatidylcholine liposomes.	Phosphatidylcholines	20-39	apolipoprotein A1	Homo sapiens	73-79
9224204-6	1997	Through the use of specific inhibitors, we demonstrate that phosphatidylcholine (PC)-specific phospholipase C (PLC) and protein kinase C (PKC) are involved in mediating the elastin message stabilization.	Phosphatidylcholines	81-83	elastin	Homo sapiens	173-180
9224650-7	1997	These results suggest that the production of DAG from phosphatidylcholine was upstream of NFkappaB activation in response to a CD14-mediated LPS stimulus.	Phosphatidylcholines	54-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-98
9201967-4	1997	The demonstration that Class II P-gps function as phosphatidylcholine (PC) translocators raise the possibility that other ABC transporters may also interact with physiological lipids.	Phosphatidylcholines	50-69	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	122-125
9201967-4	1997	The demonstration that Class II P-gps function as phosphatidylcholine (PC) translocators raise the possibility that other ABC transporters may also interact with physiological lipids.	Phosphatidylcholines	71-73	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	122-125
9201967-5	1997	We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6.	Phosphatidylcholines	56-58	phosphoglycolate phosphatase	Mus musculus	127-131
9201967-5	1997	We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6.	Phosphatidylcholines	56-58	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	190-193
9201967-5	1997	We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6.	Phosphatidylcholines	56-58	ATP binding cassette subfamily C member 3	Homo sapiens	207-210
9201966-2	1997	The interactions of recombinant SP-D with monolayers of phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylinositol (PI) spread at the air-water interface have been characterized.	Phosphatidylcholines	56-75	surfactant protein D	Rattus norvegicus	32-36
9201966-2	1997	The interactions of recombinant SP-D with monolayers of phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylinositol (PI) spread at the air-water interface have been characterized.	Phosphatidylcholines	77-79	surfactant protein D	Rattus norvegicus	32-36
9224650-7	1997	These results suggest that the production of DAG from phosphatidylcholine was upstream of NFkappaB activation in response to a CD14-mediated LPS stimulus.	Phosphatidylcholines	54-73	CD14 antigen	Mus musculus	127-131
9201967-5	1997	We report the identification of the synthetic lipid and PC analog ET-18-OCH3 (edelfosine) as a substrate for not only Class II P-gp but also for Class I P-gps and surprisingly for the other ABC transporters MRP, Pgh-1, and STE6.	Phosphatidylcholines	56-58	ATP-binding cassette a-factor transporter STE6	Saccharomyces cerevisiae S288C	223-227
9263748-2	1997	There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	280-299	phospholipase A2 group VII	Homo sapiens	141-183
9201967-11	1997	These results suggest that the group of cytotoxic synthetic PC analogs studied reveal possible structural and functional aspects common to the ABC transporters tested.	Phosphatidylcholines	60-62	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	143-146
9201967-12	1997	Furthermore, the studies with BSA and MAMO suggest that the mechanism of transport of ET-18-OCH3 by these ABC transporters may be related to the flippase mechanism of PC transport by Mdr2.	Phosphatidylcholines	167-169	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	106-109
9298595-8	1997	These results suggest that 2H2O behaves similarly to previously reported inhibitors of Na+/H+ exchange, disclosing also a novel role for PtdCho metabolism in the regulation on hepatic pHi.	Phosphatidylcholines	137-143	glucose-6-phosphate isomerase 1	Mus musculus	184-187
9263748-2	1997	There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	280-299	phospholipase A2 group VII	Homo sapiens	185-191
9263748-2	1997	There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	301-303	phospholipase A2 group VII	Homo sapiens	141-183
9263748-2	1997	There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	301-303	phospholipase A2 group VII	Homo sapiens	185-191
9188469-9	1997	hGX sPLA2 prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.	Phosphatidylcholines	47-66	phospholipase A2 group X	Homo sapiens	4-9
9237867-3	1997	The AA liberated by ET-1 appears to derive mainly from the phosphoinositides and phosphatidylcholine.	Phosphatidylcholines	81-100	endothelin 1	Homo sapiens	20-24
9211348-6	1997	Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P &lt; 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P &lt; 0.001).	Phosphatidylcholines	155-175	cytosolic phospholipase A2	Oryctolagus cuniculus	72-77
9211348-6	1997	Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P &lt; 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P &lt; 0.001).	Phosphatidylcholines	155-175	phospholipase A2	Oryctolagus cuniculus	66-70
9185174-7	1997	Bat PKC, however, made use of other phospholipids and showed relative activities of 100:81:33:42 for euthermic PKC and 100:91:45:35 for hibernator PKC with phosphatidylserine, phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine (each at 50 microM), respectively.	Phosphatidylcholines	198-217	protein kinase C, gamma	Rattus norvegicus	4-7
9194753-6	1997	Injection of a neutralizing CETP monoclonal antibody (MAb) (TP2) into natural flanking region CETP Tg mice resulted in an increase in plasma free cholesterol (FC) concentration, FC/CE ratio, FC/phosphatidylcholine ratio, and hepatic CETP mRNA.	Phosphatidylcholines	194-213	cholesteryl ester transfer protein	Homo sapiens	28-32
9219902-6	1997	Whereas venom PLA2 was cytolytic in the presence of either phosphatidylcholine or phosphatidylethanolamine (PE), rh-sPLA2 caused cell death only in the presence of PE.	Phosphatidylcholines	59-78	phospholipase A2 group IIA	Homo sapiens	14-18
9227534-6	1997	Immunohistochemical localization of P-selectin and intercellular adhesion molecule-1 (ICAM-1) expression on mesenteric venules was significantly increased after exposure to LPC compared with mesenteries superfused with phosphatidylcholine (P &lt; 0.001).	Phosphatidylcholines	219-238	selectin P	Rattus norvegicus	36-46
9227534-6	1997	Immunohistochemical localization of P-selectin and intercellular adhesion molecule-1 (ICAM-1) expression on mesenteric venules was significantly increased after exposure to LPC compared with mesenteries superfused with phosphatidylcholine (P &lt; 0.001).	Phosphatidylcholines	219-238	intercellular adhesion molecule 1	Rattus norvegicus	86-92
9200687-1	1997	The specific binding of hen egg white avidin to phosphatidylcholine lipid membranes containing spin-labeled N-biotinylphosphatidylethanolamines (biotin-PESLs) was investigated by using ESR spectroscopy.	Phosphatidylcholines	48-67	spindlin 1	Homo sapiens	95-99
9194753-6	1997	Injection of a neutralizing CETP monoclonal antibody (MAb) (TP2) into natural flanking region CETP Tg mice resulted in an increase in plasma free cholesterol (FC) concentration, FC/CE ratio, FC/phosphatidylcholine ratio, and hepatic CETP mRNA.	Phosphatidylcholines	194-213	transition protein 2	Mus musculus	60-63
9194753-7	1997	In hamsters, CETP inhibition also resulted in an increase in plasma FC/phosphatidylcholine ratio and increased CETP mRNA in adipose tissue.	Phosphatidylcholines	71-90	cholesteryl ester transfer protein	Homo sapiens	13-17
9178697-6	1997	Increased biliary immunoreactive PLA2-II levels in multiple cholesterol stones were associated with a concomitant increase in the lysophosphatidylcholine to phosphatidylcholine ratio; free arachidonate, protein, and hexosamine concentrations; and gallbladder bile viscosity.	Phosphatidylcholines	134-153	phospholipase A2 group IIA	Homo sapiens	33-37
9220345-1	1997	The physiological activator of protein kinase C (PKC), diacylglycerol, is formed by hydrolysis of phosphoinositides (PI) by phospholipase C (PLC) or phosphatidylcholine by phospholipase D (PLD).	Phosphatidylcholines	149-168	protein kinase C, delta	Rattus norvegicus	49-52
9437256-3	1997	The antioxidant effect of NAF was about 3 times less potent than that of alpha-tocopherol (alpha-TOC) in phosphatidylcholine liposomes, and NAF was about 2-4 times more efficient to decrease peroxidation of LDL than alpha-TOC.	Phosphatidylcholines	105-124	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
9215538-1	1997	Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system.	Phosphatidylcholines	151-170	lecithin-cholesterol acyltransferase	Homo sapiens	49-85
9215538-1	1997	Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system.	Phosphatidylcholines	151-170	lecithin-cholesterol acyltransferase	Homo sapiens	87-91
9223659-1	1997	In a previous study, we have reported that thrombin stimulates phosphatidylcholine hydrolysis by phospholipase (PL) D, but has little effect on phosphoinositide hydrolysis by PLC in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	63-82	coagulation factor II	Mus musculus	43-51
9215538-1	1997	Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system.	Phosphatidylcholines	151-170	apolipoprotein A1	Homo sapiens	97-115
9215538-1	1997	Interfacial binding affinities and capacities of lecithin:cholesterol acyltransferase (LCAT) and apolipoprotein A-I (apoA-I) for surfaces of different phosphatidylcholine (PC) composition, cholesterol content, and apolipoprotein content were measured with a vesicle model system.	Phosphatidylcholines	151-170	apolipoprotein A1	Homo sapiens	117-123
9148961-0	1997	Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells.	Phosphatidylcholines	0-19	carboxyl ester lipase	Homo sapiens	47-78
10024494-1	1997	Phospholipase D catalyses the hydrolysis of phosphatidylcholine to generate phosphatidate.	Phosphatidylcholines	44-63	phospholipase D	Saccharomyces cerevisiae S288C	0-15
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Phosphatidylcholines	103-105	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Phosphatidylcholines	103-105	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-2
9153219-1	1997	Lysophosphatidylcholine (lyso-PC), a natural lipid generated through the action of phospholipase A2 on membrane phosphatidylcholine, has been implicated in atherogenesis and the inflammatory process.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	83-99
9148961-0	1997	Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	84-100
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Phosphatidylcholines	178-180	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Phosphatidylcholines	178-180	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-2
9148961-8	1997	We demonstrate that both phospholipase A2 and cholesterol esterase increase cholesterol uptake by hydrolyzing the phosphatidylcholine that is used to prepare the cholesterol-containing micelles.	Phosphatidylcholines	114-133	phospholipase A2 group IB	Homo sapiens	25-41
9148961-8	1997	We demonstrate that both phospholipase A2 and cholesterol esterase increase cholesterol uptake by hydrolyzing the phosphatidylcholine that is used to prepare the cholesterol-containing micelles.	Phosphatidylcholines	114-133	carboxyl ester lipase	Homo sapiens	46-66
9176249-2	1997	In fetal lung, glucocorticoids increase synthesis of phosphatidylcholine, the principal lipid component of surfactant, and there is evidence that this effect is mediated by increased expression of the FAS gene.	Phosphatidylcholines	53-72	fatty acid synthase	Rattus norvegicus	201-204
9153408-0	1997	Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein.	Phosphatidylcholines	0-19	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
9187296-7	1997	Enhanced biosynthesis of phosphatidylcholine after partial hepatectomy was due to increased activity and amount of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	25-44	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	115-154
9115289-6	1997	Phosphatidylcholine/cholesterol liposomes containing purified Thy-1 in their membranes were much more sensitive to aerolysin than protein-free liposomes.	Phosphatidylcholines	0-19	Thy-1 cell surface antigen	Homo sapiens	62-67
9101422-5	1997	Experiments with [3H]lyso PAF indicate that human mononuclear bone marrow cells and marrow stromal cells actively acylate lyso PAF into a 1-alkyl analogue of phosphatidylcholine.	Phosphatidylcholines	158-177	PCNA clamp associated factor	Homo sapiens	26-29
9218127-7	1997	The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC.	Phosphatidylcholines	157-159	heparan sulfate proteoglycan 2	Homo sapiens	121-124
9218127-7	1997	The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC.	Phosphatidylcholines	157-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	130-133
9149106-1	1997	Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation.	Phosphatidylcholines	4-23	protein kinase C iota	Homo sapiens	276-279
9149106-1	1997	Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation.	Phosphatidylcholines	29-35	protein kinase C iota	Homo sapiens	276-279
9109516-7	1997	Stretch-induced increases in PC biosynthesis and PCT activity correlated well (r = 0.983) and were significantly reduced by pretreating (1 h) the cells with an iron chelator (deferoxamine) or scavengers of reactive oxygen species such as superoxide dismutase and catalase.	Phosphatidylcholines	29-31	catalase	Rattus norvegicus	263-271
9101422-5	1997	Experiments with [3H]lyso PAF indicate that human mononuclear bone marrow cells and marrow stromal cells actively acylate lyso PAF into a 1-alkyl analogue of phosphatidylcholine.	Phosphatidylcholines	158-177	PCNA clamp associated factor	Homo sapiens	127-130
9109447-5	1997	LPL induction of lipoprotein uptake significantly increased the rates of choline incorporation into phosphatidylcholine (PC) and disaturated PC, and these effects were associated with a three-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase.	Phosphatidylcholines	100-119	lipoprotein lipase	Rattus norvegicus	0-3
9139830-2	1997	This requirement can be relieved by inactivation of the cytosine 5"-diphosphate (CDP)-choline pathway for phosphatidylcholine biosynthesis, indicating that Sec14p is an essential component of a regulatory pathway linking phospholipid metabolism with vesicle trafficking (the Sec14p pathway).	Phosphatidylcholines	106-125	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	156-162
9205947-6	1997	RESULTS: Type II NOS production by both human and mouse cells could be prevented by the addition of the specific inhibitor of phosphatidylcholine-specific phospholipase C, D609, and of agents that interfere with the activation of NF-kappa B.	Phosphatidylcholines	126-145	nitric oxide synthase 2	Homo sapiens	9-20
9111071-0	1997	Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein kinase/extracellular signal-regulated kinase activity.	Phosphatidylcholines	22-41	mitogen-activated protein kinase 1	Mus musculus	255-292
9111071-5	1997	Reversion of v-Ras- or PC-PLC-induced transformation by expression of dominant negative lambdaPKC abolished the nuclear ERK activation suggesting lambdaPKC as a novel, direct or indirect, activator of mitogen-activated protein kinase/ERK kinase in response to activated Ras or elevated levels of phosphatidylcholine-derived diacylglycerol.	Phosphatidylcholines	296-315	mitogen-activated protein kinase 1	Mus musculus	120-123
9103463-3	1997	In this work, we show that the phospholipid component of HDL, phosphatidylcholine (PC), is both necessary and sufficient for LBP-catalyzed neutralization of LPS through either mechanism.	Phosphatidylcholines	62-81	lipopolysaccharide binding protein	Homo sapiens	125-128
9103463-3	1997	In this work, we show that the phospholipid component of HDL, phosphatidylcholine (PC), is both necessary and sufficient for LBP-catalyzed neutralization of LPS through either mechanism.	Phosphatidylcholines	83-85	lipopolysaccharide binding protein	Homo sapiens	125-128
9155155-4	1997	The other subclass, MDR3, which does not show the multidrug resistance, translocates phosphatidyl choline selectively into the outer leaflet of the liver canalicular membrane, and may protect the liver from the detergent effect of bile acids.	Phosphatidylcholines	85-105	ATP binding cassette subfamily B member 4	Homo sapiens	20-24
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Phosphatidylcholines	171-190	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Phosphatidylcholines	171-190	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Phosphatidylcholines	192-198	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Phosphatidylcholines	192-198	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
9109447-5	1997	LPL induction of lipoprotein uptake significantly increased the rates of choline incorporation into phosphatidylcholine (PC) and disaturated PC, and these effects were associated with a three-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase.	Phosphatidylcholines	121-123	lipoprotein lipase	Rattus norvegicus	0-3
9065474-2	1997	Synthesis of phosphatidylcholine and triacylglycerols was reconstituted in freshly isolated microsomes by the addition of precursors of these glycerolipids (acylcoenzyme A, glycerol 3-phosphate, and CDP-choline) before, during, or after translation.	Phosphatidylcholines	13-32	cut like homeobox 1	Canis lupus familiaris	199-202
9100011-0	1997	Pulmonary surfactant protein SP-B interacts similarly with dipalmitoylphosphatidylglycerol and dipalmitoylphosphatidylcholine in phosphatidylcholine/phosphatidylglycerol mixtures.	Phosphatidylcholines	106-125	surfactant protein B	Homo sapiens	29-33
9175129-1	1997	The role of phosphatidylcholine (PC) and phosphatidylinositol (PI) specific phospholipase C (PLC) enzymes in the release of immunoreactive arginine vasopressin (ir-AVP) from rat hypothalami in vitro was examined.	Phosphatidylcholines	12-31	arginine vasopressin	Rattus norvegicus	148-159
9054384-6	1997	Determination of the label profiles showed that cholesterol as well as phosphatidylcholine were transferred from the vesicles to PLTP.	Phosphatidylcholines	71-90	phospholipid transfer protein	Homo sapiens	129-133
9132017-9	1997	In contrast to spontaneous transfer, PLTP mediates the accumulation of PC in small rHDL particles.	Phosphatidylcholines	71-73	phospholipid transfer protein	Homo sapiens	37-41
9115999-4	1997	Slowing of cPLA2-catalyzed hydrolysis of substrates present in phosphatidylmethanol and phosphatidylcholine vesicles is primarily due to apparent inactivation rather than to substrate depletion.	Phosphatidylcholines	88-107	phospholipase A2 group IVA	Homo sapiens	11-16
9054396-5	1997	This new PLD activity was partially stimulated by phosphatidylinositol 4-phosphate, but not by other phospholipids, including phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, or phosphatidylcholine.	Phosphatidylcholines	212-231	phospholipase D alpha 1	Arabidopsis thaliana	9-12
9054384-0	1997	Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins.	Phosphatidylcholines	60-79	phospholipid transfer protein	Homo sapiens	0-29
9054384-0	1997	Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins.	Phosphatidylcholines	106-125	phospholipid transfer protein	Homo sapiens	0-29
9054384-1	1997	Phospholipid transfer protein (PLTP) purified from human plasma was found to enhance the transfer of cholesterol from single bilayer vesicles containing phosphatidylcholine and cholesterol to high density lipoprotein-3.	Phosphatidylcholines	153-172	phospholipid transfer protein	Homo sapiens	0-29
9054384-1	1997	Phospholipid transfer protein (PLTP) purified from human plasma was found to enhance the transfer of cholesterol from single bilayer vesicles containing phosphatidylcholine and cholesterol to high density lipoprotein-3.	Phosphatidylcholines	153-172	phospholipid transfer protein	Homo sapiens	31-35
9054384-7	1997	The reversible nature of the binding was shown by the transfer of labeled cholesterol and phosphatidylcholine bound to PLTP to the acceptor vesicles or low density lipoprotein.	Phosphatidylcholines	90-109	phospholipid transfer protein	Homo sapiens	119-123
9054384-5	1997	To determine the binding of cholesterol and phosphatidylcholine to PLTP, the mixtures of PLTP and the vesicles containing 3H-labeled phosphatidylcholine and 14C-labeled cholesterol were incubated and subjected to sucrose density gradient centrifugation.	Phosphatidylcholines	44-63	phospholipid transfer protein	Homo sapiens	67-71
9054384-8	1997	Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol.	Phosphatidylcholines	59-78	phospholipid transfer protein	Homo sapiens	91-95
9054384-8	1997	Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol.	Phosphatidylcholines	162-181	phospholipid transfer protein	Homo sapiens	34-38
9054384-8	1997	Isothermal equilibrium binding of PLTP for cholesterol and phosphatidylcholine showed that PLTP possessed a considerably higher affinity and binding capacity for phosphatidylcholine than for cholesterol.	Phosphatidylcholines	162-181	phospholipid transfer protein	Homo sapiens	91-95
9054384-9	1997	The phosphatidylcholine binding affinity and capacity were greater when PLTP was incubated with phosphatidylcholine vesicles without cholesterol.	Phosphatidylcholines	4-23	phospholipid transfer protein	Homo sapiens	72-76
9054384-9	1997	The phosphatidylcholine binding affinity and capacity were greater when PLTP was incubated with phosphatidylcholine vesicles without cholesterol.	Phosphatidylcholines	96-115	phospholipid transfer protein	Homo sapiens	72-76
9054396-4	1997	However, both the antisense transgenic and wild-type plants showed comparable PLD activity in the presence of submicromolar concentrations of calcium and phosphatidylinositol 4, 5-bisphosphate using phosphatidylcholine as a substrate.	Phosphatidylcholines	199-218	phospholipase D alpha 1	Arabidopsis thaliana	78-81
9057095-8	1997	These results strongly suggest that phosphatidylcholine hydrolysis by phospholipase D is involved in the arachidonic acid release induced by ET-1 in osteoblast-like cells.	Phosphatidylcholines	36-55	endothelin 1	Mus musculus	141-145
9117002-2	1997	We investigated whether human recombinant KGF (rKGF) could increase alveolar and lung-tissue saturated phosphatidyl-choline (Sat PC) in preterm rabbits delivered at 28.5 d gestation.	Phosphatidylcholines	103-123	fibroblast growth factor 7	Homo sapiens	42-45
9045633-4	1997	Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa.	Phosphatidylcholines	216-235	thrombomodulin	Homo sapiens	78-92
9045633-4	1997	Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa.	Phosphatidylcholines	216-235	thrombomodulin	Homo sapiens	94-96
9117002-2	1997	We investigated whether human recombinant KGF (rKGF) could increase alveolar and lung-tissue saturated phosphatidyl-choline (Sat PC) in preterm rabbits delivered at 28.5 d gestation.	Phosphatidylcholines	103-123	fibroblast growth factor 7	Rattus norvegicus	47-51
9084877-6	1997	We also performed inhibition assays of carbohydrate binding and of phosphatidylserine/phosphatidylcholine liposome binding of recombinant p33/41 (annexin IV) with anti-p33/41 monoclonal antibodies (AS11 and AS17).	Phosphatidylcholines	86-105	annexin A4	Bos taurus	146-156
9138891-1	1997	Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce a specific vesicle aggregation in lipid-vesicle reconstituted systems.	Phosphatidylcholines	0-20	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	195-213
9101426-13	1997	269: 2852-2862), we conclude that only apoB-truncations that assemble a neutral lipid core require phosphatidylcholine synthesis.	Phosphatidylcholines	99-118	apolipoprotein B	Rattus norvegicus	39-43
9066784-0	1997	Phosphatidylinositol- and phosphatidylcholine-dependent phospholipases C are involved in the mechanism of action of atrial natriuretic factor in cultured rat aortic smooth muscle cells.	Phosphatidylcholines	26-45	natriuretic peptide A	Rattus norvegicus	116-141
9066784-2	1997	Our results indicate that ANF initially stimulates a phosphatidylinositol-dependent phospholipase C (PI-PLC) with a significant increase of DAG, enriched in arachidonate, and inositol trisphosphate (IP3) and then a phosphatidylcholine-dependent phospholipase C (PC-PLC) with formation of DAG, enriched in myristate, and phosphocholine (Pcho).	Phosphatidylcholines	215-234	natriuretic peptide A	Rattus norvegicus	26-29
9101426-14	1997	Other experiments established that the requirement of phosphatidylcholine for apoB secretion is related to the presence of neutral lipid associated with a truncation, rather than the length of apoB.	Phosphatidylcholines	54-73	apolipoprotein B	Rattus norvegicus	78-82
9101429-7	1997	Stimulation of cells with interleukin-1 beta enhanced the synthesis of both fluorescent PI (approximately 88%) and PC (approximately 250%) compared to non-stimulated cells, but with less incorporation of 32Pi into fluorescent PI.	Phosphatidylcholines	115-117	interleukin 1 beta	Homo sapiens	26-44
9138891-1	1997	Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce a specific vesicle aggregation in lipid-vesicle reconstituted systems.	Phosphatidylcholines	0-20	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	206-213
9138891-3	1997	Because branched phosphatidylcholines containing 2-alkyl substituted fatty acid chains belong to a new class of phosphatidylcholines forming inverted nonbilayer phases the results indicate that nonbilayer lipids might play an important role in the function of mitochondrial P450SCC.	Phosphatidylcholines	17-37	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	274-281
9138891-3	1997	Because branched phosphatidylcholines containing 2-alkyl substituted fatty acid chains belong to a new class of phosphatidylcholines forming inverted nonbilayer phases the results indicate that nonbilayer lipids might play an important role in the function of mitochondrial P450SCC.	Phosphatidylcholines	112-132	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	274-281
9047367-2	1997	A three-dimensional (3D) reconstruction of BBMI was made from images of negatively stained, two-dimensional (2D) crystals grown on lipid monolayers formed from mixtures of phosphatidylserine and phosphatidylcholine.	Phosphatidylcholines	195-214	myosin IA	Homo sapiens	43-47
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	198-217	phospholipase A2 group IB	Homo sapiens	32-39
9048565-10	1997	Apolipoprotein A-IV strongly stimulated the hydrolysis of phosphatidylcholine and phosphatidylethanolamine in both lipoproteins, while the hydrolysis of triglycerides was completely inhibited.	Phosphatidylcholines	58-77	apolipoprotein A4	Homo sapiens	0-19
9070263-3	1997	Therefore, we investigated whether mdr2 P-glycoprotein is involved in the transport of a water-soluble short chain phosphatidylcholine analogue L-alpha-dibutyroyl-PC (diC4PC) induced by expression of liver mRNA in Xenopus laevis oocytes.	Phosphatidylcholines	115-134	ATP binding cassette subfamily B member 4	Rattus norvegicus	35-39
9070263-7	1997	The present data prove the existence of a specific mRNA for a non-mdr2-coded cell membrane PC carrier in mouse, rat, and human liver which exhibits similar transport affinity for diC4PC as the PC carrier in rat liver canalicular membranes.	Phosphatidylcholines	91-93	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	66-70
9124287-2	1997	PLA2 activity was measured in isolated membrane and cytosol fractions with (16:0,[3H]18:1) plasmenylcholine and (16:0,[3H]18:1) phosphatidylcholine in the absence and presence of Ca2+.	Phosphatidylcholines	128-147	phospholipase A2 group IB	Rattus norvegicus	0-4
9124287-4	1997	In the presence of Ca2+ with phosphatidylcholine, IL-1beta had no effect on membrane-associated PLA2 but decreased cytosolic PLA2 activity.	Phosphatidylcholines	29-48	interleukin 1 beta	Rattus norvegicus	50-58
9048565-4	1997	The effect of apolipoprotein A-IV on hepatic lipase-catalyzed dolichol acylation and phospholipid hydrolysis was studied in model membranes and compared with the effects of apolipoprotein A-I and E. Apolipoprotein A-IV strongly stimulated dolichol acylation and phosphatidylethanolamine hydrolysis but partly inhibited phosphatidylcholine hydrolysis.	Phosphatidylcholines	319-338	lipase C, hepatic type	Homo sapiens	37-51
9020094-8	1997	Here we show that incubation of serum-starved CHO cells with D609, a purported inhibitor of phosphatidylcholine-specific phospholipase C, also results in a mobility shift of Raf-1 that is due to hyperphosphorylation on sites identical to those observed following mitogen stimulation.	Phosphatidylcholines	92-111	RAF proto-oncogene serine/threonine-protein kinase	Cricetulus griseus	174-179
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	198-217	phospholipase A2 group IB	Homo sapiens	58-65
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	219-221	phospholipase A2 group IB	Homo sapiens	32-39
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	219-221	phospholipase A2 group IB	Homo sapiens	58-65
9032461-9	1997	Thus it appears that Lys-69 is at least partially involved in the PA specificity of hs-PLA2 and Glu-56 in the distinction between PE and PC.	Phosphatidylcholines	137-139	phospholipase A2 group IB	Homo sapiens	84-91
9017186-6	1997	As shown by CD experiments, helical conformer was induced for NG(28-43) in vesicular solution containing phosphatidyl serine (PS), whereas no helix can be discerned for the peptide in phosphatidyl choline (PC)-containing vesicular solution.	Phosphatidylcholines	206-208	neurogranin	Homo sapiens	62-64
8995259-1	1997	Human LCAT prefers phosphatidylcholine (PC) with sn-1-palmitoyl-2-oleoyl PC (POPC) as substrate for cholesteryl ester synthesis, whereas rat LCAT (which is 92% similar in amino acid sequence) prefers sn-1-palmitoyl-2-arachidonoyl PC (PAPC).	Phosphatidylcholines	19-38	lecithin cholesterol acyltransferase	Rattus norvegicus	6-10
9116917-9	1997	These results strongly suggest that the AA metabolite release induced by Ang II is mediated, at least in part, through phosphatidylcholine hydrolysis by phospholipase D activation in aortic smooth muscle cells.	Phosphatidylcholines	119-138	angiotensinogen	Rattus norvegicus	73-79
9162746-0	1997	Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction.	Phosphatidylcholines	63-82	apolipoprotein A1	Homo sapiens	146-164
9162746-0	1997	Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction.	Phosphatidylcholines	63-82	lecithin-cholesterol acyltransferase	Homo sapiens	198-234
9162746-5	1997	The activation energy of LCAT was lower for rHDL containing long chain polyunsaturated fatty acids (PUFA) compared to rHDL containing 100% POPC or 10% PC/90% OPPC ether.	Phosphatidylcholines	141-143	lecithin-cholesterol acyltransferase	Homo sapiens	25-29
9001227-3	1997	Previous studies implicated hydrolysis of phosphatidylcholine (PC) in Raf activation; therefore, we investigated the role of the epsilon isotype of protein kinase C (PKC), which is stimulated by PC-derived diacylglycerol, as a Raf activator.	Phosphatidylcholines	63-65	zinc fingers and homeoboxes 2	Mus musculus	70-73
9075205-6	1997	The concentration of phosphatidylcholine, the acyl donor in the LCAT reaction, was decreased significantly, whereas all other phospholipids were unaffected.	Phosphatidylcholines	21-40	lecithin-cholesterol acyltransferase	Homo sapiens	64-68
9108688-0	1997	Electron transfer between myoglobin and electrodes in thin films of phosphatidylcholines and dihexadecylphosphate.	Phosphatidylcholines	68-88	myoglobin	Homo sapiens	26-35
9108688-1	1997	Myoglobin (Mb) in thin films of phosphatidyl cholines (PC) or dihexadecyl phosphate (DHP) gave direct, reversible electron transfer between pyrolytic graphite electrodes and the heme Fe(III)/Fe(II) redox couple of the protein.	Phosphatidylcholines	32-53	myoglobin	Homo sapiens	0-9
9108688-1	1997	Myoglobin (Mb) in thin films of phosphatidyl cholines (PC) or dihexadecyl phosphate (DHP) gave direct, reversible electron transfer between pyrolytic graphite electrodes and the heme Fe(III)/Fe(II) redox couple of the protein.	Phosphatidylcholines	55-57	myoglobin	Homo sapiens	0-9
9116917-0	1997	Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells.	Phosphatidylcholines	209-228	angiotensinogen	Rattus norvegicus	13-27
9116917-0	1997	Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells.	Phosphatidylcholines	209-228	angiotensinogen	Rattus norvegicus	175-189
9116917-0	1997	Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D. In a previous study, we have shown that angiotensin II (Ang II) activates phosphatidylcholine-hydrolyzing phospholipase D due to Ang II-induced Ca2+ influx from extracellular space in subcultured rat aortic smooth muscle cells.	Phosphatidylcholines	209-228	angiotensinogen	Rattus norvegicus	191-197
9162748-2	1997	ApoA-I bound to phosphatidylcholine (PC) vesicles with higher affinity and lower capacity compared to triglyceride-PC emulsions.	Phosphatidylcholines	16-35	apolipoprotein A1	Homo sapiens	0-6
9074950-0	1997	Dexamethasone increases beta 2-adrenoceptor-regulated phosphatidylcholine secretion in rat alveolar type II cells.	Phosphatidylcholines	54-73	adrenoceptor beta 2	Rattus norvegicus	24-43
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	218-237	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	218-237	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	239-241	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	239-241	interleukin 1 beta	Homo sapiens	44-53
9006000-5	1997	Phosphatidylinositol (PI), phosphatidylcholine, and a fluorescently labeled derivative of phosphatidylethanolamine (R-PE) are each transferred by LBP from membranes to HDL particles.	Phosphatidylcholines	27-46	lipopolysaccharide binding protein	Homo sapiens	146-149
8995259-1	1997	Human LCAT prefers phosphatidylcholine (PC) with sn-1-palmitoyl-2-oleoyl PC (POPC) as substrate for cholesteryl ester synthesis, whereas rat LCAT (which is 92% similar in amino acid sequence) prefers sn-1-palmitoyl-2-arachidonoyl PC (PAPC).	Phosphatidylcholines	40-42	lecithin cholesterol acyltransferase	Rattus norvegicus	6-10
9096895-2	1997	An increase in the arachidonic acid content of a particular fraction of phosphatidylcholine (PC2), phosphatidylethanolamine and phosphatidylinositol between 10 and 20 days of age could be observed in the papilla, and these levels were maintained into adulthood, while in the 20:4 content of phosphatidylserine changes were found between 30-day-old rats and adults.	Phosphatidylcholines	72-91	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	93-96
9013799-7	1997	In a reconstituted system with heparin and phosphatidylcholine, 15-HPETE decreased the ability of heparin to inactivate thrombin activity.	Phosphatidylcholines	43-62	coagulation factor II, thrombin	Homo sapiens	120-128
9096895-3	1997	In the other fraction of phosphatidylcholine (PC1), saturated fatty acids such as 16:0 and 14:0 decreased, while no changes occurred in the stearic acid (18:0) content.	Phosphatidylcholines	25-44	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	46-49
9202883-2	1997	PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA).	Phosphatidylcholines	221-240	phospholipase A2 group IB	Homo sapiens	0-4
9101129-6	1997	Since PC appears to promote the breakdown of collagen, there is reasonable hope that this treatment may affect not only the progression of the disease, but may also reverse preexisting fibrosis, as demonstrated for CCl4-induced cirrhosis in the rat.	Phosphatidylcholines	6-8	C-C motif chemokine ligand 4	Rattus norvegicus	215-219
22358535-0	1997	Evidence that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of gene expression from human cytomegalovirus promoter in CHO cells.	Phosphatidylcholines	14-33	insulin	Cricetulus griseus	87-94
22358535-4	1997	These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C.	Phosphatidylcholines	39-58	insulin	Cricetulus griseus	112-119
22358535-4	1997	These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C.	Phosphatidylcholines	39-58	interleukin 6	Homo sapiens	143-148
22358535-4	1997	These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C.	Phosphatidylcholines	39-58	insulin	Cricetulus griseus	291-298
22358535-4	1997	These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C.	Phosphatidylcholines	39-58	interleukin 6	Homo sapiens	433-438
9453451-4	1997	To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats.	Phosphatidylcholines	107-126	phospholipase A2 group IB	Rattus norvegicus	66-82
8977419-5	1997	Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine).	Phosphatidylcholines	152-171	interleukin 1 beta	Rattus norvegicus	15-24
9120762-2	1997	IL-6 was lecithinized by covalently binding it with a phosphatidylcholine (lecithin, PC) derivative.	Phosphatidylcholines	54-73	interleukin 6	Mus musculus	0-4
9297603-3	1997	A mixed micelle (phosphatidylcholine (PC):lysoPC (LPC):oleic acid (OA): 2:1:1) significantly increased the release of radiolabelled products from a C-labelled poly(ester-urethane) (TDI/PCL/ED) caused by CE.	Phosphatidylcholines	17-36	carboxyl ester lipase	Homo sapiens	203-205
9297603-3	1997	A mixed micelle (phosphatidylcholine (PC):lysoPC (LPC):oleic acid (OA): 2:1:1) significantly increased the release of radiolabelled products from a C-labelled poly(ester-urethane) (TDI/PCL/ED) caused by CE.	Phosphatidylcholines	38-40	carboxyl ester lipase	Homo sapiens	203-205
9297603-6	1997	PLA caused a small but significant release of radiolabel from TDI/PCL/ED which was enhanced in the presence of its substrate, PC, and a mixture of PC with its breakdown products, LPC and OA.	Phosphatidylcholines	66-68	phospholipase A2 group IB	Homo sapiens	0-3
9297603-6	1997	PLA caused a small but significant release of radiolabel from TDI/PCL/ED which was enhanced in the presence of its substrate, PC, and a mixture of PC with its breakdown products, LPC and OA.	Phosphatidylcholines	126-128	phospholipase A2 group IB	Homo sapiens	0-3
9453451-4	1997	To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats.	Phosphatidylcholines	107-126	phospholipase A2 group IB	Rattus norvegicus	84-88
9453451-5	1997	In SOC rats the activity of phosphatidylcholine-PLA2 and PE-PLA2, the activity of PLC, and the mass of COX were significantly greater in medullary tubules than in cortical tubules.	Phosphatidylcholines	28-47	phospholipase A2 group IB	Rattus norvegicus	48-52
8981360-6	1997	The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation.	Phosphatidylcholines	19-38	FBJ osteosarcoma oncogene	Mus musculus	86-91
9553941-7	1997	The electrokinetic data for PS and PC liposomes are in good agreement with the modified theory and correlate well with the Gd3+ association constants of 5.10(4) and 10(3) M-1, respectively.	Phosphatidylcholines	35-37	GRDX	Homo sapiens	123-126
8981360-0	1997	Phosphatidylcholine signaling in response to CSF-1.	Phosphatidylcholines	0-19	colony stimulating factor 1 (macrophage)	Mus musculus	45-50
8981360-6	1997	The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation.	Phosphatidylcholines	19-38	jun B proto-oncogene	Mus musculus	96-100
8981360-4	1997	Degradation of phosphatidylcholine after CSF-1 stimulation is mediated by a phospholipase C, and the release of diacylglycerol during G1 phase is biphasic.	Phosphatidylcholines	15-34	colony stimulating factor 1 (macrophage)	Mus musculus	41-46
8981360-6	1997	The degradation of phosphatidylcholine during G1 signals the downstream activation of c-fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C. In contrast, the expression of c-myc transcripts normally associated with CSF-1 stimulation is severely compromised in phospholipase C-treated cells, indicating that the diacylglycerol signals a pathway distinct from the pathway that governs c-myc activation.	Phosphatidylcholines	19-38	colony stimulating factor 1 (macrophage)	Mus musculus	289-294
9007991-5	1997	As monitored by anti-factor IX:Ca (II)-specific antibodies and by the quenching of intrinsic fluorescence, all these factor IX species underwent the Ca(II)-induced conformational transition required for phospholipid membrane binding and bound equivalently to phospholipid vesicles composed of phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine.	Phosphatidylcholines	313-332	carbonic anhydrase 2	Homo sapiens	149-155
9454375-0	1997	[Effects of fatty acid amides on phosphatidylcholine hydrolysis catalyzed by phospholipase A2 in micelles].	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	77-93
16793657-2	1997	The adhesion of platelets stimulated with thrombin or ADP was dramatically increased when the platelet cholesterol content was enriched by incubation with cholesterol containing phosphatidylcholine vesicles.	Phosphatidylcholines	178-197	coagulation factor II, thrombin	Homo sapiens	42-50
9454375-1	1997	The effect of fatty acid amides on the hydrolysis of natural phosphatidylcholine and its semisynthetic analog, dioleoyl phosphatidylcholine, catalyzed by phospholipase A2 in mixed micelles with Triton X-100 has been studied.	Phosphatidylcholines	61-80	phospholipase A2 group IB	Homo sapiens	154-170
8978464-9	1996	These results strongly suggest that bFGF activates phosphatidylcholine-hydrolyzing phospholipase D through the activation of tyrosine kinase, but independently of PKC activated by phosphoinositide hydrolysis in osteoblast-like cells.	Phosphatidylcholines	51-70	fibroblast growth factor 2	Mus musculus	36-40
9060137-3	1997	In addition to the decrease in LCAT activity, the concentrations of phosphatidylcholine (a fatty aryl donor for esterification of free cholesterol) and of cholesteryl esters (products of the LCAT reaction) were reduced in the high-density lipoprotein fractions from cows with fatty livers.	Phosphatidylcholines	68-87	lecithin-cholesterol acyltransferase	Homo sapiens	191-195
9060137-5	1997	These results suggest that the decreased LCAT activity, which may be attributable to impaired hepatic secretion or to the suppression of the activity in the plasma by reduced concentrations of phosphatidylcholine and apolipoprotein A-I, resulted in the lower concentrations of cholesteryl esters.	Phosphatidylcholines	193-212	lecithin-cholesterol acyltransferase	Bos taurus	41-45
9003363-5	1996	Analysis of the fractions using exogenous phosphatidylcholine as substrate confirmed the presence of ARF1-dependent PLD activity in endomembranes and plasma membrane, and also identified an additional activity in the cytosol.	Phosphatidylcholines	42-61	ADP ribosylation factor 1	Homo sapiens	101-105
9003363-5	1996	Analysis of the fractions using exogenous phosphatidylcholine as substrate confirmed the presence of ARF1-dependent PLD activity in endomembranes and plasma membrane, and also identified an additional activity in the cytosol.	Phosphatidylcholines	42-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	116-119
8978464-0	1996	Basic fibroblast growth factor stimulates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells.	Phosphatidylcholines	42-61	fibroblast growth factor 2	Mus musculus	0-30
8978464-1	1996	We examined the effect of basic fibroblast growth factor (bFGF) on the activation of phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	85-104	fibroblast growth factor 2	Mus musculus	26-56
8978464-1	1996	We examined the effect of basic fibroblast growth factor (bFGF) on the activation of phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	85-104	fibroblast growth factor 2	Mus musculus	58-62
8940040-5	1996	Only the apoE-secreting cells and only in the presence of 8-Br-cAMP released large amounts of labeled cholesterol or phosphatidylcholine into the medium.	Phosphatidylcholines	117-136	apolipoprotein E	Homo sapiens	9-13
8978672-1	1996	The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis.	Phosphatidylcholines	238-257	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	49-55
8997228-0	1996	Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase.	Phosphatidylcholines	27-47	lecithin cholesterol acyltransferase	Rattus norvegicus	81-85
8997228-0	1996	Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase.	Phosphatidylcholines	27-47	lipase C, hepatic type	Rattus norvegicus	90-104
8996638-0	1996	Role of stearoyl-CoA desaturase in the modification of acyl composition of hepatic phosphatidylcholine by peroxisome proliferators.	Phosphatidylcholines	83-102	stearoyl-CoA desaturase	Rattus norvegicus	8-31
8996638-3	1996	With administration of these peroxisome proliferators, the proportion of oleic acid in C-2 position of PtdCho in hepatic microsomes was increased in commensurate with the increase in activities of stearoyl-CoA desaturase and 1-acyl-GPC acyltransferase.	Phosphatidylcholines	103-109	stearoyl-CoA desaturase	Rattus norvegicus	197-220
9131406-7	1996	By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and <protein-id="291987">UTP.	Phosphatidylcholines	302-321	protein kinase C, alpha	Rattus norvegicus	90-99
9131406-7	1996	By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and <protein-id="291987">UTP.	Phosphatidylcholines	302-321	protein kinase C, alpha	Rattus norvegicus	90-93
8931495-1	1996	Nerve growth cones isolated from fetal rat brain exhibit in their cytosol a robust level of phospholipase A2 activity hydrolyzing phosphatidylinositol (PI) and phosphatidylethanolamine (PE) but not phosphatidylcholine (PC).	Phosphatidylcholines	219-221	phospholipase A2 group IB	Rattus norvegicus	92-108
8961931-9	1996	Using flavocytochrome b558 reconstituted into phosphatidylcholine vesicles, the EC50 for Rac1 but not Rac2 decreased (increased binding) when an acidic phospholipid (phosphatidylinositol) was present, supporting a role for the Rac1 polybasic C terminus in binding to the membrane.	Phosphatidylcholines	46-65	Rac family small GTPase 1	Homo sapiens	89-93
8938187-2	1996	After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet.	Phosphatidylcholines	202-221	spindlin 1	Homo sapiens	52-56
8938187-2	1996	After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet.	Phosphatidylcholines	223-225	spindlin 1	Homo sapiens	52-56
8940023-3	1996	The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A).	Phosphatidylcholines	261-280	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	108-113
8940023-3	1996	The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A).	Phosphatidylcholines	261-280	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	108-113
8940023-3	1996	The inhibition is not due to a general toxicity of v-H-Ras(G60A) to oocytes because oocytes injected with v-H-Ras(G60A) can be readily induced to mature by other mitogenic agents, such as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-specific phospholipase C. The dominant negative effect of v-H-Ras(G60A) requires proper membrane attachment of v-H-Ras(G60A).	Phosphatidylcholines	261-280	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	108-113
8944749-9	1996	A novel method for continuous assay of phospholipase A2 activity with BSA-HCA and a mixed phosphatidylcholine/CHAPS micellar substrate is reported.	Phosphatidylcholines	90-109	phospholipase A2 group IB	Homo sapiens	39-55
8941338-1	1996	The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV).	Phosphatidylcholines	68-87	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	38-53
8941338-1	1996	The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV).	Phosphatidylcholines	68-87	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	55-61
8941338-1	1996	The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV).	Phosphatidylcholines	89-91	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	38-53
8941338-1	1996	The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV).	Phosphatidylcholines	89-91	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	55-61
8941649-4	1996	In addition, we have recently shown that HDL3 stimulates the hydrolysis of phosphatidylcholine (PC) in cholesterol-loaded fibroblasts.	Phosphatidylcholines	75-94	HDL3	Homo sapiens	41-45
8941649-4	1996	In addition, we have recently shown that HDL3 stimulates the hydrolysis of phosphatidylcholine (PC) in cholesterol-loaded fibroblasts.	Phosphatidylcholines	96-98	HDL3	Homo sapiens	41-45
8941649-5	1996	To investigate whether this cell signaling pathway is involved in cholesterol efflux mechanisms, we compared the HDL3-induced PC hydrolysis in normal fibroblasts and in fibroblasts from a TD kindred, in whom the HDL3- and apolipoprotein A-I (apo A-I)-induced mobilization of cellular cholesterol was found to be reduced by 50%.	Phosphatidylcholines	126-128	HDL3	Homo sapiens	113-117
8939917-12	1996	D609, an inhibitor of phosphatidylcholine-specific phospholipase C, completely prevented the killing by TNF, but not by ceramide, in the presence of ActD.	Phosphatidylcholines	22-41	tumor necrosis factor	Homo sapiens	104-107
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	60-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-30
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	60-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	32-35
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	60-79	protein kinase C alpha	Homo sapiens	214-217
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	81-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-30
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	81-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	32-35
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Phosphatidylcholines	81-87	protein kinase C alpha	Homo sapiens	214-217
8910539-4	1996	Stable expression of PKC-alpha in MCF-7 cells, which was accompanied by increased levels of the betaI- and theta-isoforms as well, greatly enhanced both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydrolysis of PtdEtn (2.5-2.9-fold) and PtdCho (5.5-7.2-fold).	Phosphatidylcholines	282-288	protein kinase C alpha	Homo sapiens	21-30
8961306-4	1996	In the present report we demonstrate by immunofluorescence that short-treatment of C 6 glial cells with phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC), changes the intracellular localization of protein kinase C (PKC) zeta from the cytoplasm to a perinuclear region.	Phosphatidylcholines	104-123	protein kinase C zeta	Homo sapiens	222-225
8824283-8	1996	All glycosaminoglycans tested, at concentrations up to 100 microM, increased the activity of phospholipase A2 toward phosphatidylcholine liposomes.	Phosphatidylcholines	117-136	phospholipase A2 group IB	Homo sapiens	93-109
8914830-1	1996	Electron spin resonance (ESR) spectroscopy and spin label techniques have been used to study the effects of fumonisin B1 (FB1) and hydrolyzed fumonisin backbone (AP1) on the structural and dynamic properties of phosphatidylcholine membranes at the molecular level.	Phosphatidylcholines	211-230	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-165
8898203-0	1996	MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
8898203-0	1996	MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 1	Homo sapiens	5-19
8898203-0	1996	MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 4	Homo sapiens	71-75
8898203-0	1996	MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.	Phosphatidylcholines	117-136	ATP binding cassette subfamily B member 1	Homo sapiens	76-90
8898203-2	1996	The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile.	Phosphatidylcholines	40-59	ATP binding cassette subfamily B member 4	Homo sapiens	15-19
8898203-2	1996	The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile.	Phosphatidylcholines	40-59	ATP binding cassette subfamily B member 1	Homo sapiens	20-23
8898203-6	1996	MDR3 cells exclusively released a short-chain phosphatidylcholine.	Phosphatidylcholines	46-65	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
8978486-1	1996	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations.	Phosphatidylcholines	108-127	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
8978486-1	1996	Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations.	Phosphatidylcholines	108-127	phosphatidylethanolamine N-methyltransferase	Homo sapiens	46-50
8901526-2	1996	We used ellipsometry to study the binding of beta 2GPI and the beta 2GPI-mediated binding of ACA to planar membranes composed of phosphatidylcholine (PC) and 5-20 mol % phosphatidylserine (PS).	Phosphatidylcholines	129-148	apolipoprotein H	Homo sapiens	63-72
8901526-2	1996	We used ellipsometry to study the binding of beta 2GPI and the beta 2GPI-mediated binding of ACA to planar membranes composed of phosphatidylcholine (PC) and 5-20 mol % phosphatidylserine (PS).	Phosphatidylcholines	150-152	apolipoprotein H	Homo sapiens	63-72
8957238-4	1996	We show that both drugs inhibit, in an equimolar manner, the activity of phospholipase A1 (assayed for phosphatidylcholine, included in negatively charged liposomes), in a way consistent with the model of "charge neutralization" proposed already for gentamicin (Mingeot-Leclercq et al., 1988, Biochem.	Phosphatidylcholines	103-122	lipase H	Homo sapiens	73-89
8930892-3	1996	Thrombin and carbachol induce comparable changes in phosphoinositide and phosphatidylcholine hydrolysis, mobilization of intracellular Ca2+, diglyceride generation, and redistribution of protein kinase C; thus, activation of these Gq-signaling pathways appears to be insufficient for gene expression and mitogenesis.	Phosphatidylcholines	73-92	coagulation factor II, thrombin	Homo sapiens	0-8
8876250-1	1996	The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes.	Phosphatidylcholines	167-186	microsomal triglyceride transfer protein	Homo sapiens	51-54
8810347-0	1996	The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast.	Phosphatidylcholines	12-31	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	70-74
8810270-4	1996	Association of as little as 5 mol of phosphatidylcholine with apoA-I is sufficient to transform lipid-free apoA-I into a distinct lipoprotein-like particle that is a significantly better acceptor of cellular cholesterol.	Phosphatidylcholines	37-56	apolipoprotein A1	Homo sapiens	62-68
8810270-4	1996	Association of as little as 5 mol of phosphatidylcholine with apoA-I is sufficient to transform lipid-free apoA-I into a distinct lipoprotein-like particle that is a significantly better acceptor of cellular cholesterol.	Phosphatidylcholines	37-56	apolipoprotein A1	Homo sapiens	107-113
8810347-7	1996	Rather, we report that when the rate of synthesis of PC becomes growth limiting, the addition of inositol fails to repress the phospholipid biosynthetic genes, but when the rate of PC synthesis is sufficient to sustain normal growth, the addition of inositol to the growth medium has the effect of repressing INO1 and other phospholipid biosynthetic genes.	Phosphatidylcholines	53-55	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	309-313
8810347-2	1996	In yeast, PC biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol.	Phosphatidylcholines	10-12	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	111-115
8810347-4	1996	We report that repression of INO1 transcription in response to inositol is clearly dependent on ongoing PC biosynthesis, but it is independent of the route of synthesis.	Phosphatidylcholines	104-106	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	29-33
8897886-5	1996	Lysophosphatidylcholine (lysoPC) (0.01-5,000 ng/ml), one of the products of phosphatidylcholine by PLA2, dose-dependently enhanced IEC-6 cell migration as well.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Rattus norvegicus	99-103
8798752-2	1996	In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol.	Phosphatidylcholines	106-125	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-68
8857918-1	1996	Triglycerides (TGs), cholesteryl esters (CEs), cholesterol, and phosphatidylcholine have been independently proposed as playing regulatory roles in apoB-100 secretion; the results depended on the cellular model used.	Phosphatidylcholines	64-83	apolipoprotein B	Homo sapiens	148-156
8894140-0	1996	Function of Ca2+ in phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblast-like cells.	Phosphatidylcholines	20-39	carbonic anhydrase 2	Mus musculus	12-15
8894140-1	1996	We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	58-77	carbonic anhydrase 2	Mus musculus	32-35
8894140-1	1996	We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	79-81	carbonic anhydrase 2	Mus musculus	32-35
8855796-9	1996	The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho.	Phosphatidylcholines	89-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	169-172
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	116-135	interleukin 1 beta	Rattus norvegicus	33-42
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Rattus norvegicus	69-85
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Rattus norvegicus	87-91
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	137-139	interleukin 1 beta	Rattus norvegicus	33-42
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	137-139	phospholipase A2 group IB	Rattus norvegicus	69-85
8828503-3	1996	We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells.	Phosphatidylcholines	137-139	phospholipase A2 group IB	Rattus norvegicus	87-91
8855796-9	1996	The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho.	Phosphatidylcholines	184-190	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	169-172
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Phosphatidylcholines	102-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-82
8794341-13	1996	Liposomes composed of phosphatidylcholine and microsomes (to simulate ER membranes) were broken when observed by electron microscopy after incubation with NSP4 or the NSP4(114-135) peptide.	Phosphatidylcholines	22-41	serine protease 57	Homo sapiens	155-159
8794341-13	1996	Liposomes composed of phosphatidylcholine and microsomes (to simulate ER membranes) were broken when observed by electron microscopy after incubation with NSP4 or the NSP4(114-135) peptide.	Phosphatidylcholines	22-41	serine protease 57	Homo sapiens	167-171
8798386-0	1996	Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis.	Phosphatidylcholines	187-206	mitogen-activated protein kinase 1	Homo sapiens	50-54
8798386-9	1996	Our data suggest that phosphatidylinositol 3-kinase and phosphatidylcholine-specific phospholipase C represent components of different, but partly overlapping pathways that can account almost entirely for the activation of ERK2 by the 5-HT1A receptor.	Phosphatidylcholines	56-75	mitogen-activated protein kinase 1	Homo sapiens	223-227
8798386-9	1996	Our data suggest that phosphatidylinositol 3-kinase and phosphatidylcholine-specific phospholipase C represent components of different, but partly overlapping pathways that can account almost entirely for the activation of ERK2 by the 5-HT1A receptor.	Phosphatidylcholines	56-75	5-hydroxytryptamine receptor 1A	Homo sapiens	235-250
9414418-6	1996	HePC inhibited fMLP induced phosphatidylinositol-specific PLC activation in HL60 cells and TNF-alpha induced activation of phosphatidylcholine-specific PLC in U937 cells.	Phosphatidylcholines	123-142	tumor necrosis factor	Homo sapiens	91-100
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Phosphatidylcholines	102-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Phosphatidylcholines	123-129	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-82
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Phosphatidylcholines	123-129	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
8905167-4	1996	Circulating [3H]PAM is incorporated into sn-1 positions of brain phospholipids, mainly phosphatidylcholine, and its rate of turnover is thought to reflect turnover of neuronal and glial membranes.	Phosphatidylcholines	87-106	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	16-19
8856074-7	1996	In membranes of toxin-B-treated cells, basal and GTP[S]-stimulated PLD activities were reduced, when measured with exogenous phosphatidylcholine as enzyme substrate.	Phosphatidylcholines	125-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-70
8856074-8	1996	Inclusion of PtdIns(4,5)P2 with phosphatidylcholine in the substrate vesicles or addition of PtdIns(4,5)P2 fully restored basal and GTP[S]-stimulated PLD activities in membranes of toxin-B-treated cells.	Phosphatidylcholines	32-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	150-153
8843783-0	1996	TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes is sequentially mediated by PGE2 and NO.	Phosphatidylcholines	32-34	tumor necrosis factor	Homo sapiens	0-9
8843783-5	1996	The D-[U-14C] glucose incorporation into phosphatidylcholine (PC) was selectively inhibited by TNF-alpha, PGE2, sodium nitroprusside (SNP), or 8-bromoguanosine 3",5"-cyclic monophosphate.	Phosphatidylcholines	41-60	tumor necrosis factor	Homo sapiens	95-104
8843783-5	1996	The D-[U-14C] glucose incorporation into phosphatidylcholine (PC) was selectively inhibited by TNF-alpha, PGE2, sodium nitroprusside (SNP), or 8-bromoguanosine 3",5"-cyclic monophosphate.	Phosphatidylcholines	62-64	tumor necrosis factor	Homo sapiens	95-104
8843783-10	1996	Our results suggest that NO generation, secondary to PGE2 production, is responsible for the TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes.	Phosphatidylcholines	125-127	tumor necrosis factor	Homo sapiens	93-102
9011184-1	1996	Using fluorescent probe 4-(dimethylaminostyryl)-1-methylpridine n-toluenesulfonate (DSM) the effect of ribonuslease and lysozyme on the structure of liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been studied.	Phosphatidylcholines	171-190	lysozyme	Homo sapiens	120-128
8906563-2	1996	Correlation with metabolism of membrane phospholipids suggests that PKC-alpha and MARCKS may be required to mediate phosphatidylcholine turnover stimulated by phorbol ester (beta-TPA).	Phosphatidylcholines	116-135	protein kinase C alpha	Homo sapiens	68-77
8906563-2	1996	Correlation with metabolism of membrane phospholipids suggests that PKC-alpha and MARCKS may be required to mediate phosphatidylcholine turnover stimulated by phorbol ester (beta-TPA).	Phosphatidylcholines	116-135	myristoylated alanine rich protein kinase C substrate	Homo sapiens	82-88
8906563-8	1996	Thus, induced differentiation of human neuroblastoma cells involved increased expression of PKC-alpha and MARCKS and synthesis of phosphatidylcholine, consistent with involvement of PKC-alpha and MARCKS in regulation of phosphatidylcholine turnover during neurite growth.	Phosphatidylcholines	220-239	protein kinase C alpha	Homo sapiens	182-191
8906563-8	1996	Thus, induced differentiation of human neuroblastoma cells involved increased expression of PKC-alpha and MARCKS and synthesis of phosphatidylcholine, consistent with involvement of PKC-alpha and MARCKS in regulation of phosphatidylcholine turnover during neurite growth.	Phosphatidylcholines	220-239	myristoylated alanine rich protein kinase C substrate	Homo sapiens	196-202
8877882-10	1996	Phosphatidylcholine, a substrate for the gene product of the class III P-gp gene, produced significant inhibition of [3H]DNM transport (30.6% at a 10-fold-higher substrate concentration), suggesting that transport may be mediated, at least in part, by this P-gp gene product.	Phosphatidylcholines	0-19	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	71-75
8877882-10	1996	Phosphatidylcholine, a substrate for the gene product of the class III P-gp gene, produced significant inhibition of [3H]DNM transport (30.6% at a 10-fold-higher substrate concentration), suggesting that transport may be mediated, at least in part, by this P-gp gene product.	Phosphatidylcholines	0-19	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	257-261
8888372-8	1996	These results suggest that the cytidine moiety of CDP-choline stimulates phosphatidylcholine synthesis in human brain cell membranes in older subjects.	Phosphatidylcholines	73-92	cut like homeobox 1	Homo sapiens	50-53
8962916-2	1996	The data indicate that in lymphocyte membranes, enzymatic system of cascade deacylation of the phosphatidylcholine fraction includes calcium-activated phospholipase A1 and lysophospholipase.	Phosphatidylcholines	95-114	phospholipase A2 group IVA	Homo sapiens	172-189
8831934-12	1996	An extensive hydrolysis of the endogenous phosphatidylcholine (PC) to lysophosphatidylcholine (lyso-PC) was observed during Lp(a) oxidation, since the Lyso-PC/sphingomyelin molar ratio at the end of oxidation (0.55 +/- 0.09) was significantly higher than that before oxidation (0.19 +/- 0.01, P &lt; 0.001).	Phosphatidylcholines	42-61	lipoprotein(a)	Homo sapiens	124-129
8831934-12	1996	An extensive hydrolysis of the endogenous phosphatidylcholine (PC) to lysophosphatidylcholine (lyso-PC) was observed during Lp(a) oxidation, since the Lyso-PC/sphingomyelin molar ratio at the end of oxidation (0.55 +/- 0.09) was significantly higher than that before oxidation (0.19 +/- 0.01, P &lt; 0.001).	Phosphatidylcholines	63-65	lipoprotein(a)	Homo sapiens	124-129
8831934-15	1996	During Lp(a) oxidation, the PAF-AH activity decreases whereas an extensive hydrolysis of the endogenous PC to Lyso-PC is observed which is possibly due to the PAF-AH activity.	Phosphatidylcholines	104-106	lipoprotein(a)	Homo sapiens	7-12
8831934-15	1996	During Lp(a) oxidation, the PAF-AH activity decreases whereas an extensive hydrolysis of the endogenous PC to Lyso-PC is observed which is possibly due to the PAF-AH activity.	Phosphatidylcholines	104-106	phospholipase A2 group VII	Homo sapiens	159-165
8842223-2	1996	Binding of cytochrome c to cardiolipin/phosphatidylcholine membranes in the absence of oxidase.	Phosphatidylcholines	39-58	LOC104968582	Bos taurus	11-23
8842223-3	1996	The mechanism of interaction between cytochrome c and a solid-supported planar phosphatidylcholine membrane containing varying amounts of cardiolipin (0-20 mol%) has been studied over a wide range of protein concentrations (0-450 microM) and ionic strength conditions (10-150 mM), by direct measurement of protein binding using surface plasmon resonance (SPR) spectroscopy.	Phosphatidylcholines	79-98	LOC104968582	Bos taurus	37-49
8842224-2	1996	Binding of cytochrome c to oxidase-containing cardiolipin/phosphatidylcholine membranes.	Phosphatidylcholines	58-77	LOC104968582	Bos taurus	11-23
8842224-3	1996	Complex formation between horse heart cytochrome c (cyt c) and bovine cytochrome c oxidase (cco) incorporated into a supported planar egg phosphatidylcholine membrane containing varying amounts of cardiolipin (CL) (0-20 mol%) has been studied under low (10 mM) and medium (160 mM) ionic strength conditions by surface plasmon resonance (SPR) spectroscopy.	Phosphatidylcholines	138-157	cytochrome c, somatic	Equus caballus	52-57
8842224-3	1996	Complex formation between horse heart cytochrome c (cyt c) and bovine cytochrome c oxidase (cco) incorporated into a supported planar egg phosphatidylcholine membrane containing varying amounts of cardiolipin (CL) (0-20 mol%) has been studied under low (10 mM) and medium (160 mM) ionic strength conditions by surface plasmon resonance (SPR) spectroscopy.	Phosphatidylcholines	138-157	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	70-90
8760826-0	1996	Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock.	Phosphatidylcholines	78-97	tumor necrosis factor	Mus musculus	20-41
8960386-2	1996	In the present study, we investigated the susceptibility of the phosphatidylcholine component of two exogenous surfactants, Exosurf and Survanta, to secretory-type phospholipase A2 (PLA2) deacylation in vitro.	Phosphatidylcholines	64-83	phospholipase A2 group IB	Homo sapiens	164-180
8960386-2	1996	In the present study, we investigated the susceptibility of the phosphatidylcholine component of two exogenous surfactants, Exosurf and Survanta, to secretory-type phospholipase A2 (PLA2) deacylation in vitro.	Phosphatidylcholines	64-83	phospholipase A2 group IB	Homo sapiens	182-186
8960386-4	1996	The phosphatidylcholine component of Survanta was readily deacylated by PLA2, whereas the dipalmitoylphosphatidycholine (DPPC) component of Exosurf was resistant over the entire duration of the assay.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	72-76
8760826-0	1996	Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock.	Phosphatidylcholines	78-97	tumor necrosis factor	Mus musculus	124-145
8760826-0	1996	Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock.	Phosphatidylcholines	78-97	tumor necrosis factor	Mus musculus	147-150
8760826-1	1996	We have investigated the role of a TNF-responsive phosphatidylcholine-specific phospholipase C (PC-PLC) for the cytotoxic and proinflammatory activity of TNF.	Phosphatidylcholines	50-69	tumor necrosis factor	Mus musculus	35-38
8760826-1	1996	We have investigated the role of a TNF-responsive phosphatidylcholine-specific phospholipase C (PC-PLC) for the cytotoxic and proinflammatory activity of TNF.	Phosphatidylcholines	50-69	tumor necrosis factor	Mus musculus	154-157
8764605-1	1996	Phospholipase D activity of rat brain neuronal nuclei, measured with exogenous phosphatidylcholine as substrate, was characterized.	Phosphatidylcholines	79-98	RNA binding fox-1 homolog 3	Rattus norvegicus	38-53
8804611-2	1996	Here we have used SPR spectroscopy for the first time to monitor the binding and activation of G-protein (transducin or Gt) by bovine rhodopsin incorporated into an egg phosphatidylcholine bilayer deposited on a silver film.	Phosphatidylcholines	169-188	rhodopsin	Bos taurus	134-143
8768693-8	1996	These data suggest that phosphatidylcholine-specific phospholipase C is involved in the ANG II signaling pathway leading to stimulation of L-type Ca++ channels by protein kinase C.	Phosphatidylcholines	24-43	angiotensinogen	Rattus norvegicus	88-94
8755731-1	1996	Glycophorin A was reconstituted into large unilamellar vesicles of egg phosphatidylcholine by detergent dialysis.	Phosphatidylcholines	71-90	glycophorin A (MNS blood group)	Homo sapiens	0-13
8695654-2	1996	Inhibition of cholesterol esterification in HepG2 cells, by the ACAT inhibitor 447C88, partially reduced the secretion of labelled total cholesterol, but the secretion of apoprotein B mass, and of radiolabelled triacylglycerol and phosphatidylcholine were unaffected.	Phosphatidylcholines	231-250	sterol O-acyltransferase 1	Homo sapiens	64-68
8695654-4	1996	In contrast, the less potent ACAT inhibitor, CL277,082, significantly decreased secretion of labelled triacylglycerol, phosphatidylcholine and total cholesterol, in a manner which mirrored the decreases in secretion of apoB.	Phosphatidylcholines	119-138	sterol O-acyltransferase 1	Homo sapiens	29-33
8783331-9	1996	In addition, the inhibitory effect of TNF alpha on phosphatidylcholine labeling was attenuated in cryopreserved islets compared with noncryopreserved islets.	Phosphatidylcholines	51-70	tumor necrosis factor	Homo sapiens	38-47
8647917-0	1996	Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis.	Phosphatidylcholines	64-83	coagulation factor II	Mus musculus	0-8
8647917-1	1996	We examined the effect of thrombin on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	38-57	coagulation factor II	Mus musculus	26-34
8647917-14	1996	These results suggest that thrombin stimulates phosphatidylcholine-hydrolyzing phospholipase D due to self-induced Ca2+ influx independently of protein kinase C activation in osteoblast-like cells and that its proliferative effect depends on phospholipase D activation.	Phosphatidylcholines	47-66	coagulation factor II	Mus musculus	27-35
8770926-0	1996	Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes.	Phosphatidylcholines	45-64	insulin	Homo sapiens	0-7
8770926-0	1996	Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes.	Phosphatidylcholines	45-64	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	19-34
8770926-2	1996	In particular, insulin effects on the hydrolysis of phosphatidylcholine (PC) and subsequent activation of protein kinase C (PKC) have not been apparent in some studies.	Phosphatidylcholines	52-71	insulin	Homo sapiens	15-22
8770926-2	1996	In particular, insulin effects on the hydrolysis of phosphatidylcholine (PC) and subsequent activation of protein kinase C (PKC) have not been apparent in some studies.	Phosphatidylcholines	73-75	insulin	Homo sapiens	15-22
8770926-4	1996	We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol.	Phosphatidylcholines	96-98	insulin	Homo sapiens	14-21
8770926-4	1996	We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol.	Phosphatidylcholines	96-98	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-65
8770926-4	1996	We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol.	Phosphatidylcholines	96-98	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-70
8679568-1	1996	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	115-134	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
8679568-1	1996	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC) for function.	Phosphatidylcholines	136-138	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
8679568-8	1996	Endogenous PC in the insect cells fulfills the lipid requirement for the expressed BDH since enzymatic activity is lost upon digestion with phospholipase A2 and restored selectively by reconstitution with PC vesicles.	Phosphatidylcholines	11-13	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	83-86
8679568-8	1996	Endogenous PC in the insect cells fulfills the lipid requirement for the expressed BDH since enzymatic activity is lost upon digestion with phospholipase A2 and restored selectively by reconstitution with PC vesicles.	Phosphatidylcholines	11-13	phospholipase A2 group IB	Homo sapiens	140-156
8664328-9	1996	L-FABP expression also selectively stimulated [3H]oleic acid incorporation into choline glycerophospholipids.	Phosphatidylcholines	80-108	fatty acid binding protein 1	Homo sapiens	0-6
8663014-2	1996	The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB.	Phosphatidylcholines	57-76	sphingomyelin phosphodiesterase 1	Homo sapiens	4-27
8663014-2	1996	The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB.	Phosphatidylcholines	57-76	sphingomyelin phosphodiesterase 1	Homo sapiens	29-36
8663014-2	1996	The acidic sphingomyelinase (A-SMase) pathway involves a phosphatidylcholine-specific phospholipase C, an endosomal A-SMase, and controls expression of multiple TNF-responsive genes through induction of transcription factors such as NF-kappaB.	Phosphatidylcholines	57-76	tumor necrosis factor	Homo sapiens	161-164
8666200-1	1996	Cells of the pel1 mutant of Saccharomyces cerevisiae were found to contain an extremely low content of cardiolipin, a decreased level of phosphatidylcholine and an increased level of phosphatidylinositol.	Phosphatidylcholines	137-156	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	Saccharomyces cerevisiae S288C	13-17
8679658-4	1996	Removal of endogenous lipids from OG-Glut1 abolished the activity unless phosphatidylcholine was included in the eluent.	Phosphatidylcholines	73-92	solute carrier family 2 member 1	Homo sapiens	37-42
8649360-0	1996	D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.	Phosphatidylcholines	8-27	interleukin 1 beta	Homo sapiens	71-89
8662812-3	1996	Treatment of macrophages with inhibitors of proteoglycan synthesis (4-methylumbelliferyl-beta-D-xyloside) or sulfation (sodium chlorate) enhanced the release of apoE from cells and significantly attenuated the increase in secretion produced by incubation with phosphatidylcholine vesicles (PV).	Phosphatidylcholines	260-279	apolipoprotein E	Homo sapiens	161-165
8808758-3	1996	Pretreatment of neutrophils with TNF-alpha caused a rapid increase in the incorporation of [1-14C]20:4(n-6) substrate into cellular phosphatidylinositol and phosphatidic acid and a slower rise in the incorporation into phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	219-238	tumor necrosis factor	Homo sapiens	33-42
8679706-6	1996	The fifth pig Pgp gene shows similarity to the phosphatidylcholine-translocating Class III isoform.	Phosphatidylcholines	47-66	phosphoglycolate phosphatase	Sus scrofa	14-17
8808758-12	1996	These data collectively provide evidence that TNF-alpha specifically induces the turnover of neutrophil phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine, which are enriched with 20:4(n-6) by the activation of phospholipase A2.	Phosphatidylcholines	126-145	tumor necrosis factor	Homo sapiens	46-55
8649360-0	1996	D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.	Phosphatidylcholines	8-27	vascular cell adhesion molecule 1	Homo sapiens	98-131
8649360-3	1996	We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta.	Phosphatidylcholines	28-47	vascular cell adhesion molecule 1	Homo sapiens	93-99
8649360-3	1996	We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta.	Phosphatidylcholines	28-47	interleukin 1 beta	Homo sapiens	119-137
8649360-4	1996	D609, a phosphatidylcholine-specific phospholipase C inhibitor, reduced VCAM-1 cell surface expression and VCAM-1 promoter activity in human endothelial cells in a dose-dependent manner.	Phosphatidylcholines	8-27	vascular cell adhesion molecule 1	Homo sapiens	72-78
8649360-6	1996	The results of this study indicate that phosphatidylcholine-specific phospholipase C is required for activation of nuclear factor-kappa B and cytokine induction of VCAM-1 gene expression in endothelial cells.	Phosphatidylcholines	40-59	vascular cell adhesion molecule 1	Homo sapiens	164-170
8639617-1	1996	The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy.	Phosphatidylcholines	145-165	cystathionine beta-synthase	Homo sapiens	115-118
8681425-2	1996	Phosphatidylcholine is the major substrate for PLD.	Phosphatidylcholines	0-19	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	47-50
8681431-3	1996	A phosphatidylcholine-specific PLD activity was recently purified from pig lung, but its possible regulation by PKC has not been reported yet.	Phosphatidylcholines	2-21	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
8694508-0	1996	Detection of phosphatidylcholine-specific phospholipase C in NIH-3T3 fibroblasts and their H-ras transformants: NMR and immunochemical studies.	Phosphatidylcholines	13-32	HRas proto-oncogene, GTPase	Homo sapiens	91-96
8662615-10	1996	Mature TC II-R dimerized upon insertion into synthetic phosphatidylcholine vesicles of different fatty acyl chain length (dimyristoyl, dipalmitoyl, and disteroyl phosphatidylcholine) in the absence or the presence of cholesterol at temperatures below or above their transition temperatures, respectively.	Phosphatidylcholines	55-74	transcobalamin 2	Homo sapiens	7-12
8662651-3	1996	14C-Labeled PC was introduced into the OMV from small unilamellar vesicles by a PC-specific transfer protein (PCTP).	Phosphatidylcholines	12-14	phosphatidylcholine transfer protein	Rattus norvegicus	80-108
8662651-3	1996	14C-Labeled PC was introduced into the OMV from small unilamellar vesicles by a PC-specific transfer protein (PCTP).	Phosphatidylcholines	12-14	phosphatidylcholine transfer protein	Rattus norvegicus	110-114
8662651-4	1996	The membrane topology of the newly introduced PC was determined from its accessibility to phospholipase A2.	Phosphatidylcholines	46-48	phospholipase A2 group IB	Rattus norvegicus	90-106
8662651-5	1996	Under conditions where the OMV stay intact, externally added phospholipase A2 is able to hydrolyze up to 50% of both the introduced [14C]PC and the endogenous PC.	Phosphatidylcholines	137-139	phospholipase A2 group IB	Rattus norvegicus	61-77
8662651-5	1996	Under conditions where the OMV stay intact, externally added phospholipase A2 is able to hydrolyze up to 50% of both the introduced [14C]PC and the endogenous PC.	Phosphatidylcholines	159-161	phospholipase A2 group IB	Rattus norvegicus	61-77
8694509-1	1996	Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	91-135
8645147-2	1996	Here we demonstrate by two independent methods that Akt-1 from L6 myotubes binds to PtdIns(3,4,5)P3, PtdIns(3,4)P2 and PtdIns(4,5)P2 when presented against a background of phosphatidylserine (PtdSer) or a 1:1 mixture of PtdSer and phosphatidylcholine (PtdCho).	Phosphatidylcholines	231-250	AKT serine/threonine kinase 1	Homo sapiens	52-57
8694509-1	1996	Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	41-60	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	137-141
8645147-2	1996	Here we demonstrate by two independent methods that Akt-1 from L6 myotubes binds to PtdIns(3,4,5)P3, PtdIns(3,4)P2 and PtdIns(4,5)P2 when presented against a background of phosphatidylserine (PtdSer) or a 1:1 mixture of PtdSer and phosphatidylcholine (PtdCho).	Phosphatidylcholines	252-258	AKT serine/threonine kinase 1	Homo sapiens	52-57
8694509-4	1996	Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis.	Phosphatidylcholines	187-206	cut-like homeobox 1	Rattus norvegicus	163-166
8847457-12	1996	Phosphatidylcholine containing [14C]-AA in Sn-2 (150,000 dpm) was incubated with cytosol of uterine myometrium and the amounts of [14C]-AA released were calculated as Phospholipase A2 activity.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	167-183
8792123-4	1996	BALF PLA2 showed marked selectivity for phosphatidylcholine containing arachidonic acid (AA) over linoleic or palmitic acids.	Phosphatidylcholines	40-59	phospholipase A2 group IB	Homo sapiens	5-9
8805276-1	1996	BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA).	Phosphatidylcholines	81-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-46
8805276-1	1996	BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA).	Phosphatidylcholines	81-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	48-51
8725726-2	1996	TFPI was shown to bind calcium-independently to an acidic phospholipid surface composed of phosphatidylserine, but not a surface composed of the neutral phosphatidylcholine.	Phosphatidylcholines	153-172	tissue factor pathway inhibitor	Homo sapiens	0-4
8633059-1	1996	Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins.	Phosphatidylcholines	121-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-29
9273720-1	1996	Using fluorescent probes DSM, DSP-6 and DSP-12 interaction of methemoglobin with liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been investigated.	Phosphatidylcholines	103-122	hemoglobin subunit gamma 2	Homo sapiens	62-75
8633059-1	1996	Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins.	Phosphatidylcholines	121-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
8633059-1	1996	Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins.	Phosphatidylcholines	142-148	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-29
8633059-1	1996	Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins.	Phosphatidylcholines	142-148	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
8633059-3	1996	This PLD preferentially used PtdCho as substrate.	Phosphatidylcholines	29-35	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	5-8
8633059-8	1996	The results suggest that mammalian PLD reacts nearly selectively with PtdCho in the form of mixed micelles or membranes with other phospholipids, especially PtdEtn.	Phosphatidylcholines	70-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-38
8670105-7	1996	Calmodulin activates the enzyme 1.5-1.8-fold in the presence of phosphatidylcholine but not in the presence of phosphatidylserine.	Phosphatidylcholines	64-83	calmodulin-3	Sus scrofa	0-10
8664287-1	1996	Bilayers composed of phosphatidylcholine initially resist catalysis by phospholipase A2.	Phosphatidylcholines	21-40	phospholipase A2 group IB	Homo sapiens	71-87
8626542-7	1996	In addition, the C2A domain of synaptotagmin IV cannot bind liposomes consisting of PS (or PI) and phosphatidylcholine, PC (or phosphatidylethanolamine, PE) (1:1, w/w), indicating that the binding to negatively charged phospholipids is inhibited by the presence of PC or PE.	Phosphatidylcholines	99-118	synaptotagmin 4	Homo sapiens	31-47
8743192-5	1996	However, the potentiating effect of HDL3 was completely blocked in the presence of the protein kinase C inhibitor, bisindoylmaleimide and the phosphatidylcholine-specific phospholipase C inhibitor, D609.	Phosphatidylcholines	142-161	HDL3	Homo sapiens	36-40
8613911-8	1996	Furthermore, PKC-mediated contraction may be augmented by additional diacylglycerol production arising from the hydrolysis of phosphatidylcholine by phosphatidylcholine-specific phospholipase C.	Phosphatidylcholines	126-145	proline rich transmembrane protein 2	Homo sapiens	13-16
8613911-8	1996	Furthermore, PKC-mediated contraction may be augmented by additional diacylglycerol production arising from the hydrolysis of phosphatidylcholine by phosphatidylcholine-specific phospholipase C.	Phosphatidylcholines	149-168	proline rich transmembrane protein 2	Homo sapiens	13-16
8627336-0	1996	Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells.	Phosphatidylcholines	106-125	myristoylated alanine rich protein kinase C substrate	Homo sapiens	18-24
8627336-0	1996	Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells.	Phosphatidylcholines	106-125	hedgehog acyltransferase	Homo sapiens	135-139
8627336-2	1996	In five clones with a less than fivefold increase in MARCKS protein level, the synthesis of PtdCho from [methyl-3H] choline was stimulated 1.88-2.34-fold in the presence of 100-200 nM TPA.	Phosphatidylcholines	92-98	myristoylated alanine rich protein kinase C substrate	Homo sapiens	53-59
8627336-2	1996	In five clones with a less than fivefold increase in MARCKS protein level, the synthesis of PtdCho from [methyl-3H] choline was stimulated 1.88-2.34-fold in the presence of 100-200 nM TPA.	Phosphatidylcholines	92-98	plasminogen activator, tissue type	Homo sapiens	184-187
8615772-0	1996	Regulation of phosphatidylcholine synthesis in maturing type II cells: increased mRNA stability of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	14-33	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	99-138
8608156-3	1996	ApoA-IV bound to the surface of the microemulsion in equilibrium with a similar affinity to that of other helical apolipoproteins, and activated the transfer reaction by CETP of cholesteryl ester, triacylglycerol and phosphatidylcholine between the emulsions.	Phosphatidylcholines	217-236	apolipoprotein A4	Homo sapiens	0-7
8615772-2	1996	This increase is accompanied by an increase in gene and protein expression of CTP:phosphocholine cytidylyltransferase (CT; EC 2.7.7.15), which catalyses a regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells.	Phosphatidylcholines	182-201	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	78-117
8670072-8	1996	Phosphatidylcholine also increased the basolateral secretion of apolipoprotein B (apoB) mass without altering apoB mRNA levels.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	64-80
8621399-7	1996	The C-terminal part of the 80-kDa protein (amino acids 597-737) is similar to sterol carrier protein 2 and facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes in vitro.	Phosphatidylcholines	160-179	sterol carrier protein 2	Homo sapiens	78-102
8615695-2	1996	(R)-3-Hydroxybutyrate dehydrogenase (BDH; EC 1.1.1.30) is a lipid-requiring enzyme with a specific requirement of phosphatidylcholine for optimal function.	Phosphatidylcholines	114-133	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	37-40
8615695-9	1996	These results suggest that the binding of BDH to the phosphatidylcholine head group is independent of its interaction with the apolar core of the phospholipid bilayer.	Phosphatidylcholines	53-72	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	42-45
8678916-10	1996	These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis.	Phosphatidylcholines	45-64	angiotensinogen	Rattus norvegicus	27-33
8678916-10	1996	These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis.	Phosphatidylcholines	45-64	angiotensinogen	Rattus norvegicus	212-218
8678916-10	1996	These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis.	Phosphatidylcholines	270-289	angiotensinogen	Rattus norvegicus	27-33
8678916-10	1996	These results suggest that Ang II stimulates phosphatidylcholine-hydrolyzing phospholipase D due to Ca2+ influx from the extracellular space in rat aortic SMC, and that protein tyrosine kinase is involved in the Ang II-induced Ca2+ influx, resulting in the promotion of phosphatidylcholine hydrolysis.	Phosphatidylcholines	270-289	angiotensinogen	Rattus norvegicus	212-218
8670072-8	1996	Phosphatidylcholine also increased the basolateral secretion of apolipoprotein B (apoB) mass without altering apoB mRNA levels.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	82-86
8670072-9	1996	Disruption of the Golgi apparatus by monensin or brefeldin A prevented the increase in apoB secretion by phosphatidylcholine.	Phosphatidylcholines	105-124	apolipoprotein B	Homo sapiens	87-91
8670072-10	1996	Compared with microsomes prepared from control cells, those from cells incubated with phosphatidylcholine contained more newly synthesized apoB.	Phosphatidylcholines	86-105	apolipoprotein B	Homo sapiens	139-143
8670072-12	1996	Thus in CaCo-2 cells incubated with phosphatidylcholine, the transport of apoB and triacylglycerols is increased whereas cholesteryl ester synthesis and secretion are decreased.	Phosphatidylcholines	36-55	apolipoprotein B	Homo sapiens	74-78
8678916-1	1996	In the present study, we examined the effect of angiotensin II (Ang II) on phosphatidylcholine-hydrolyzing phospholipase D activity in subcultured rat aortic smooth muscle cells (SMC).	Phosphatidylcholines	75-94	angiotensinogen	Rattus norvegicus	48-62
8724608-7	1996	The presence in HETSR cells of p60-src whose synthesis is not controlled by dexamethasone may be responsible for increased phosphatidylcholine metabolism and sustaining cell growth under conditions of limited activity of growth-promoting compounds.	Phosphatidylcholines	123-142	sequestosome 1	Homo sapiens	31-34
8723652-1	1996	Competitive binding of fluorescent probe 4-(n-dimethylaminostyryl)-1-methylpyiridinium n-toluenesulfonate and lysozyme to liposomes composed of phosphatidylcholine and diphosphatidylglycerol has been investigated.	Phosphatidylcholines	144-163	lysozyme	Homo sapiens	110-118
8678916-1	1996	In the present study, we examined the effect of angiotensin II (Ang II) on phosphatidylcholine-hydrolyzing phospholipase D activity in subcultured rat aortic smooth muscle cells (SMC).	Phosphatidylcholines	75-94	angiotensinogen	Rattus norvegicus	64-70
8868466-6	1996	Small unilamellar phosphatidyl choline:cholesterol vesicles loaded with FGF-2 increased uPA production in GM 7373 cells in the absence of a mitogenic response.	Phosphatidylcholines	18-38	fibroblast growth factor 2	Bos taurus	72-77
8612652-4	1996	Under these conditions, TNF-alpha induced the hydrolysis of PtdCho but did not promote the hydrolysis of 3H-labeled sphingomyelin, suggesting that the sphingomyelin signaling pool resides in a compartment distal to the Golgi apparatus, and possibly in the plasma membrane.	Phosphatidylcholines	60-66	tumor necrosis factor	Homo sapiens	24-33
8612652-6	1996	However, TNF caused PtdCho and sphingomyelin degradation in fibroblasts that had been treated with bacterial sphingomyelinase to degrade the sphingomyelin pool of the external leaflet of the plasma membrane.	Phosphatidylcholines	20-26	tumor necrosis factor	Homo sapiens	9-12
8612652-9	1996	In addition, when [3H]choline-labeled fibroblasts were treated under non-lytic conditions with bacterial phospholipase C to degrade the external pool of PtdCho, TNF was still able to stimulate the hydrolysis of PtdCho.	Phosphatidylcholines	153-159	tumor necrosis factor	Homo sapiens	161-164
8612652-9	1996	In addition, when [3H]choline-labeled fibroblasts were treated under non-lytic conditions with bacterial phospholipase C to degrade the external pool of PtdCho, TNF was still able to stimulate the hydrolysis of PtdCho.	Phosphatidylcholines	211-217	tumor necrosis factor	Homo sapiens	161-164
8728318-2	1996	We compared glycosylation structure, enzyme kinetics, and phosphatidylcholine (PC) acyl specificity of human LCAT from four sources: human plasma (pLCAT), media from HepG2 cells (HepG2 LCAT), media from SF21 cells infected with a recombinant baculovirus (bLCAT) and media from stably transfected Chinese hamster ovary (CHO) cells (CHO LCAT).	Phosphatidylcholines	58-77	lecithin-cholesterol acyltransferase	Homo sapiens	109-113
8868466-6	1996	Small unilamellar phosphatidyl choline:cholesterol vesicles loaded with FGF-2 increased uPA production in GM 7373 cells in the absence of a mitogenic response.	Phosphatidylcholines	18-38	plasminogen activator, urokinase	Bos taurus	88-91
8576263-5	1996	We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	106-125	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	127-166
8867924-7	1996	fMLP, but not tBuBHQ, caused BAPTA/AM-sensitive activation of phospholipase A2 and D. tBuBHQ caused O2- production by interacting with phosphatidylcholine in a cell-free system.	Phosphatidylcholines	135-154	formyl peptide receptor 1	Homo sapiens	0-4
8867924-7	1996	fMLP, but not tBuBHQ, caused BAPTA/AM-sensitive activation of phospholipase A2 and D. tBuBHQ caused O2- production by interacting with phosphatidylcholine in a cell-free system.	Phosphatidylcholines	135-154	phospholipase A2 group IB	Homo sapiens	62-78
8597585-7	1996	Second, human and guinea pig LCAT were purified and used in phosphatidylcholine-reconstituted vesicles containing human apoAI to show their ability to esterify tritiated cholesterol, PREG, and DHEA in the absence of unlabeled steroid.	Phosphatidylcholines	60-79	phosphatidylcholine-sterol acyltransferase	Cavia porcellus	29-33
8576189-2	1996	We have named this open reading frame, PLD1, and show that yeast bearing a disruption in this gene are unable to catalyze the hydrolysis of phosphatidylcholine.	Phosphatidylcholines	140-159	phospholipase D	Saccharomyces cerevisiae S288C	39-43
8576189-7	1996	This is the first identification of a eukaryotic, nonplant, phosphatidylcholine-hydrolyzing phospholipase D gene.	Phosphatidylcholines	60-79	phospholipase D	Saccharomyces cerevisiae S288C	92-107
8597587-0	1996	Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions.	Phosphatidylcholines	46-65	solute carrier family 38 member 5	Bos taurus	108-112
8576263-5	1996	We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	106-125	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	176-220
8576263-5	1996	We screened the major tissues for the activities of two important enzymes involved in the biosynthesis of phosphatidylcholine, CTP:phosphocholine cytidylyltransferase (CT) and phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylcholines	106-125	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	222-226
8576263-9	1996	The labeling of phosphatidylcholine in isolated hepatocytes from CD rats was consistent with the conversion of PE to PC being increased as a result of a higher expression of liver PEMT.	Phosphatidylcholines	16-35	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	180-184
8850316-1	1996	After the administration of the recombinant human tumor necrosis factor (rHuTNF), plasma concentration could be controlled from egg yolk phosphatidylcholine (eggPC)-egg yolk phosphatidic acid (eggPA) liposome (EggPA liposome).	Phosphatidylcholines	137-156	tumor necrosis factor	Homo sapiens	50-71
8611143-2	1996	Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane.	Phosphatidylcholines	60-79	protein kinase C, alpha	Rattus norvegicus	185-194
8611143-2	1996	Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane.	Phosphatidylcholines	60-79	protein kinase C, beta	Rattus norvegicus	199-207
8611143-2	1996	Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane.	Phosphatidylcholines	81-83	protein kinase C, alpha	Rattus norvegicus	185-194
8611143-2	1996	Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane.	Phosphatidylcholines	81-83	protein kinase C, beta	Rattus norvegicus	199-207
8611148-13	1996	Phosphatidylcholine (and its structural analogue sphingomyelin) were the best lipid activators of Cpt1p, the main biologically relevant CPT activity in S. cerevisiae.	Phosphatidylcholines	0-19	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	98-103
9034754-2	1996	Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner.	Phosphatidylcholines	12-31	heparan sulfate proteoglycan 2	Homo sapiens	66-69
8882734-4	1996	Similar immunogenicity was displayed by free Gfpt1 in muramyldipeptide-phosphoethanolamine-containing phosphatidyl-choline, -serine (PC,PS) liposomes.	Phosphatidylcholines	102-122	glutamine fructose-6-phosphate transaminase 1	Mus musculus	45-50
9386267-2	1996	PEMT catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in hepatocytes.	Phosphatidylcholines	61-80	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	0-4
8770209-0	1996	Calorimetry of apolipoprotein-A1 binding to phosphatidylcholine-triolein-cholesterol emulsions.	Phosphatidylcholines	44-63	apolipoprotein A1	Homo sapiens	15-32
8770209-17	1996	This value indicates that apo-A1 binding to a fluid surface like egg yolk phosphatidylcholine or probably DPPC at 45 degrees C is hydrophobic and is consistent with hydrocarbon lipid or protein moities coming together and excluding water.	Phosphatidylcholines	74-93	apolipoprotein A1	Homo sapiens	26-32
9034754-2	1996	Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner.	Phosphatidylcholines	33-35	heparan sulfate proteoglycan 2	Homo sapiens	66-69
8618893-2	1995	When assayed by measuring the phosphatidyl transfer reaction to ethanol with exogenously added radioactive phosphatidylcholine as substrate, the PLD required a high concentration (1.6 M) of ammonium sulfate to exhibit high enzymatic activity.	Phosphatidylcholines	107-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	145-148
8699936-4	1996	Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP.	Phosphatidylcholines	73-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-36
8699936-4	1996	Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP.	Phosphatidylcholines	73-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	38-41
8699936-4	1996	Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP.	Phosphatidylcholines	73-92	formyl peptide receptor 1	Homo sapiens	121-125
8554602-1	1995	Lysophosphatidylcholine (LysoPC), which is formed by phospholipase A2 (PLA2)-mediated phosphatidylcholine hydrolysis, is involved in enhancement of the diacylglycerol- or phorbol ester-dependent protein kinase C (PKC) activation.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Rattus norvegicus	53-69
8554602-1	1995	Lysophosphatidylcholine (LysoPC), which is formed by phospholipase A2 (PLA2)-mediated phosphatidylcholine hydrolysis, is involved in enhancement of the diacylglycerol- or phorbol ester-dependent protein kinase C (PKC) activation.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Rattus norvegicus	71-75
11725084-4	1996	A cellular phospholipase A(2) with an arachidonyl specificity at the sn-2 position of phosphatidylcholine, which required submicromolar calcium, was identified as a cytosolic phospholipase A(2) by immunoblot analysis.	Phosphatidylcholines	86-105	LOC104974671	Bos taurus	11-28
11725084-4	1996	A cellular phospholipase A(2) with an arachidonyl specificity at the sn-2 position of phosphatidylcholine, which required submicromolar calcium, was identified as a cytosolic phospholipase A(2) by immunoblot analysis.	Phosphatidylcholines	86-105	LOC104974671	Bos taurus	175-192
8820101-7	1996	The epitope of this antibody resides in oxidized products of phosphatidylcholine that can form complexes with polypeptides, including apolipoprotein B.	Phosphatidylcholines	61-80	apolipoprotein B	Homo sapiens	134-150
8820107-0	1996	Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates.	Phosphatidylcholines	122-141	lecithin-cholesterol acyltransferase	Canis lupus familiaris	52-88
8554325-6	1995	The lipid which tended to be associated with rhodopsin in protein-lipid-detergent mixed micelles was also consistently richer in PC than that present in lipid-detergent micelles.	Phosphatidylcholines	129-131	rhodopsin	Bos taurus	45-54
8541336-0	1995	The enhancement of phosphatidylcholine biosynthesis by angiotensin II in H9c2 cells.	Phosphatidylcholines	19-38	angiotensinogen	Rattus norvegicus	55-69
8530346-1	1995	Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-58
8530346-1	1995	Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.	Phosphatidylcholines	14-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-63
8530346-3	1995	Characterization of recombinant human PLD1 reveals that it is membrane-associated, selective for phosphatidylcholine, stimulated by phosphatidylinositol 4,5-bisphosphate, activated by the monomeric G-protein ADP-ribosylation factor-1, and inhibited by oleate.	Phosphatidylcholines	97-116	phospholipase D1	Homo sapiens	38-42
8541336-1	1995	The effect of angiotensin II on the biosynthesis of phosphatidylcholine in rat heart myoblastic (H9c2) cells was investigated.	Phosphatidylcholines	52-71	angiotensinogen	Rattus norvegicus	14-28
8541336-3	1995	When cells were pretreated with angiotensin II, a significant increase in the labelling of phosphatidylcholine was observed.	Phosphatidylcholines	91-110	angiotensinogen	Rattus norvegicus	32-46
8541336-4	1995	Analysis of the labelled phosphatidylcholine precursors indicated that the conversion of phosphocholine to CDP-choline was enhanced by angiotensin II treatment.	Phosphatidylcholines	25-44	angiotensinogen	Rattus norvegicus	135-149
8541336-9	1995	We conclude that the increase in phosphatidylcholine biosynthesis by angiotensin II was a direct result of the enhancement of the cytidylyltransferase activity.	Phosphatidylcholines	33-52	angiotensinogen	Rattus norvegicus	69-83
7492275-7	1995	RESULTS: The incorporation of 14C-labeled glucose (D-[U-14C]glucose) into phosphatidylcholine and phosphatidylglycerol was selectively inhibited either by 8-Br-cGMP or in the presence of TNF-alpha, PGE2, or nitroprusside, all of which caused an increase in the intracellular levels of cGMP.	Phosphatidylcholines	74-93	tumor necrosis factor	Homo sapiens	187-196
11854811-5	1995	We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	102-121	taxilin alpha	Homo sapiens	17-22
11854811-5	1995	We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	102-121	phospholipase A2 group IB	Homo sapiens	31-49
11854811-5	1995	We observed that IL-14 induces phospholipase A(2) (PLA(2))-dependent release of arachidonic acid from phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	102-121	phospholipase A2 group IB	Homo sapiens	51-57
7498535-3	1995	At physiological ionic strength (130 mM KCl) ezrin interacts strongly with liposomes containing &gt; or = 5% phosphatidylinositol-4,5-bisphosphate (PIP2), the residual being phosphatidylcholine (PC).	Phosphatidylcholines	174-193	ezrin	Homo sapiens	45-50
7498535-3	1995	At physiological ionic strength (130 mM KCl) ezrin interacts strongly with liposomes containing &gt; or = 5% phosphatidylinositol-4,5-bisphosphate (PIP2), the residual being phosphatidylcholine (PC).	Phosphatidylcholines	195-197	ezrin	Homo sapiens	45-50
7492275-14	1995	CONCLUSIONS: The NO generation, secondary to PGE2 production, seems responsible for the TNF-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes.	Phosphatidylcholines	120-139	tumor necrosis factor	Homo sapiens	88-97
8618786-1	1995	CTP:phosphocholine cytidylyltransferase (CT) catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine (PC).	Phosphatidylcholines	117-136	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
8846779-0	1995	Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.	Phosphatidylcholines	88-107	Fas cell surface death receptor	Homo sapiens	39-44
8846779-0	1995	Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.	Phosphatidylcholines	88-107	Fas cell surface death receptor	Homo sapiens	46-50
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	sphingomyelin phosphodiesterase 1	Homo sapiens	138-161
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	sphingomyelin phosphodiesterase 1	Homo sapiens	163-169
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	Fas cell surface death receptor	Homo sapiens	223-228
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	sphingomyelin phosphodiesterase 1	Homo sapiens	237-243
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	Fas cell surface death receptor	Homo sapiens	268-273
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	sphingomyelin phosphodiesterase 2	Homo sapiens	282-306
8846779-3	1995	Activation of a phosphatidylcholine-specific phospholipase C (PC-PLC) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1-induced aSMase activation, but not Fas/APO-1-induced neutral sphingomyelinase (nSMase) activation.	Phosphatidylcholines	16-35	sphingomyelin phosphodiesterase 2	Homo sapiens	308-314
8547181-4	1995	In addition, a purified recombinant peptide derived from the SCP2-related domain of the 17 beta-HSD type IV has about 30% of the transfer activities for 7-dehydrocholesterol and phosphatidylcholine seen with purified recombinant human SCP2.	Phosphatidylcholines	178-197	sterol carrier protein 2	Homo sapiens	61-65
8653540-3	1995	Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL.	Phosphatidylcholines	12-31	lipase E, hormone sensitive type	Rattus norvegicus	106-109
8653540-4	1995	These results suggest that the active HSL is already present in the fat cell even in the absence of lipolytic hormone, and phosphatidylcholine on the surface of endogenous lipid droplets causes inhibition toward lipolytic action of HSL.	Phosphatidylcholines	123-142	lipase E, hormone sensitive type	Rattus norvegicus	232-235
8789601-6	1995	We investigated whether expression of specific PKC isoforms might correlate with these effects of phorbol esters on PtdCho synthesis.	Phosphatidylcholines	116-122	protein kinase C alpha	Homo sapiens	47-50
8789601-13	1995	Accordingly, stimulation of PtdCho turnover by phorbol esters correlated only with expression of PKC-alpha; presence of PKC-beta alone was insufficient for a TPA response.	Phosphatidylcholines	28-34	protein kinase C alpha	Homo sapiens	97-106
8618786-1	1995	CTP:phosphocholine cytidylyltransferase (CT) catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine (PC).	Phosphatidylcholines	138-140	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
7499345-8	1995	Similar to microsomal RoDH and RoDH(I), RoDH(II) had higher activity with NADP rather than NAD, was stimulated by ethanol and phosphatidyl choline, was not inhibited by the medium-chain alcohol dehydrogenase inhibitor 4-methylpyrazole, but was inhibited by phenylarsine oxide and the short-chain dehydrogenase/reductase inhibitor carbenoxolone.	Phosphatidylcholines	126-146	retinol dehydrogenase 7	Rattus norvegicus	31-38
7499345-8	1995	Similar to microsomal RoDH and RoDH(I), RoDH(II) had higher activity with NADP rather than NAD, was stimulated by ethanol and phosphatidyl choline, was not inhibited by the medium-chain alcohol dehydrogenase inhibitor 4-methylpyrazole, but was inhibited by phenylarsine oxide and the short-chain dehydrogenase/reductase inhibitor carbenoxolone.	Phosphatidylcholines	126-146	retinol dehydrogenase 16	Rattus norvegicus	40-48
8600835-2	1995	Phosphatidylcholines containing an arachidonyl chain at the sn-2 position and either a 10-pyrenedecyl or a 10-pyrenedecanoyl chain at the sn-1 position were synthesized and shown to be substrates for cPLA2 in a fluorescence-based assay.	Phosphatidylcholines	0-20	phospholipase A2 group IVA	Homo sapiens	200-205
7475000-1	1995	Reconstituted high-density lipoprotein (rHDL), an artificial lipoprotein consisting of apolipoprotein A-I and phosphatidylcholine (1:150, molar ratios) dose-dependently reduces lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF) production in in vitro, ex-vivo, and in-vivo model systems.	Phosphatidylcholines	110-129	tumor necrosis factor	Oryctolagus cuniculus	210-237
7583579-2	1995	HDL3 elicited phosphatidylcholine (PC) and phosphatidylinositol (PI) turnover and activated multiple phospholipases.	Phosphatidylcholines	14-33	HDL3	Homo sapiens	0-4
7583579-2	1995	HDL3 elicited phosphatidylcholine (PC) and phosphatidylinositol (PI) turnover and activated multiple phospholipases.	Phosphatidylcholines	35-37	HDL3	Homo sapiens	0-4
7583579-3	1995	In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol.	Phosphatidylcholines	13-15	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	115-118
7487093-1	1995	The effects of expression of the H-ras oncogene on phosphatidylcholine metabolism were examined in C3H10T1/2 and NIH3T3 cells expressing ras constitutively or under the control of inducible promoters.	Phosphatidylcholines	51-70	Harvey rat sarcoma virus oncogene	Mus musculus	33-38
8593248-0	1995	Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29).	Phosphatidylcholines	0-19	epidermal growth factor	Homo sapiens	87-90
8593248-3	1995	), we have shown that epidermal growth factor (EGF) increased protein kinase C (PKC) activities in colon carcinoma cell line (HT29), possibly through the increased 1,2-diacylglycerol (1,2-DAG) production via phosphatidylcholine (PC).	Phosphatidylcholines	208-227	epidermal growth factor	Homo sapiens	22-51
8593248-3	1995	), we have shown that epidermal growth factor (EGF) increased protein kinase C (PKC) activities in colon carcinoma cell line (HT29), possibly through the increased 1,2-diacylglycerol (1,2-DAG) production via phosphatidylcholine (PC).	Phosphatidylcholines	229-231	epidermal growth factor	Homo sapiens	22-51
8593248-4	1995	Here we investigate the effect of well-known PKC activator 12-O-tetradecanoyl-2 phorbol-13-acetate (TPA), on the levels of 32P incorporation into EGF induced phosphatidylinositols (PI, PI4P, PI4, 5P2) and different phospholipids (PC, PA, PS) as well as on induced tyrosine kinase activity.	Phosphatidylcholines	230-232	epidermal growth factor	Homo sapiens	146-149
8593248-5	1995	TPA significantly decreased the effects of EGF and it had the biggest inhibitory effect on EGF induced PC level.	Phosphatidylcholines	103-105	epidermal growth factor	Homo sapiens	91-94
8593248-6	1995	These data support our contention that PC plays an important role in the activation of PKC via 1,2-DAG production in the EGF stimulated pathway.	Phosphatidylcholines	39-41	epidermal growth factor	Homo sapiens	121-124
7475000-1	1995	Reconstituted high-density lipoprotein (rHDL), an artificial lipoprotein consisting of apolipoprotein A-I and phosphatidylcholine (1:150, molar ratios) dose-dependently reduces lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF) production in in vitro, ex-vivo, and in-vivo model systems.	Phosphatidylcholines	110-129	tumor necrosis factor	Oryctolagus cuniculus	239-242
8788774-1	1995	The influence of chronic administration of cytidine-5"-diphosphate choline (CDP-choline), a precursor of the membrane lipid phosphatidylcholine, was studied in neurosecretory neurons (NSNs) of the supraoptic nucleus (SON) of aged mouse hypothalamus.	Phosphatidylcholines	124-143	cut-like homeobox 1	Mus musculus	76-79
7592669-2	1995	We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells.	Phosphatidylcholines	93-112	tumor necrosis factor	Homo sapiens	38-47
7577962-7	1995	Concentrations of K+ above 150 mM caused dissociation of MBP from LUVs containing PC and a single acidic lipid.	Phosphatidylcholines	82-84	myelin basic protein	Homo sapiens	57-60
7577961-2	1995	Prothrombinase was assembled at a macroscopic phospholipid membrane, composed of 25 mol % phosphatidylserine and 75 mol % phosphatidylcholine, deposited on the inner wall of a glass capillary, by perfusion with a factor Xa-factor Va mixture.	Phosphatidylcholines	122-141	coagulation factor X	Homo sapiens	0-14
7577962-3	1995	Therefore, the effect of K+ concentration on the ability of MBP to aggregate large unilamellar vesicles (LUVs) containing phosphatidylcholine (PC) and 10-20% acidic lipid was investigated.	Phosphatidylcholines	122-141	myelin basic protein	Homo sapiens	60-63
7577962-3	1995	Therefore, the effect of K+ concentration on the ability of MBP to aggregate large unilamellar vesicles (LUVs) containing phosphatidylcholine (PC) and 10-20% acidic lipid was investigated.	Phosphatidylcholines	143-145	myelin basic protein	Homo sapiens	60-63
7487907-0	1995	Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol.	Phosphatidylcholines	22-41	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	178-181
7487907-0	1995	Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol.	Phosphatidylcholines	135-154	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	178-181
7487907-0	1995	Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. The regulation of phosphatidylcholine (PtdCho) hydrolysis by Ca2+ and protein kinase C (PKC) was measured in [3H]palmitate-labelled cultured guinea-pig airway smooth-muscle cells as phosphatidylbutanol ([3H]PtdBut) and phosphatidate ([3H]PtdOH) formation in the presence of butanol.	Phosphatidylcholines	156-162	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	178-181
7487907-6	1995	Ionomycin, a Ca2+ ionophore, induced PtdCho hydrolysis to a greater extent than bradykinin, also in an extracellular-Ca(2+)-dependent manner.	Phosphatidylcholines	37-43	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	13-16
7592669-2	1995	We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells.	Phosphatidylcholines	93-112	interleukin 1 beta	Homo sapiens	52-61
8584016-5	1995	When the cells were pulse labelled with [3H]-choline, vasopressin stimulation caused a decrease in the labelled phosphatidylcholine with a corresponding increase in the labelled choline.	Phosphatidylcholines	112-131	arginine vasopressin	Rattus norvegicus	54-65
8640350-0	1995	Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.	Phosphatidylcholines	19-38	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-68
8584016-7	1995	Alternatively, the labelled choline produced by vasopressin stimulation was released into the medium, thus reducing the recycling of label precursor back into the phospholipid and making the decrease in the labelling of phosphatidylcholine readily detectable.	Phosphatidylcholines	220-239	arginine vasopressin	Rattus norvegicus	48-59
8825031-3	1995	Phosphatidylcholines with short (C14) or long (C24) fatty acyl chains have marked effects on the activity of the ATPase, including a change in the stoichiometry of Ca binding.	Phosphatidylcholines	0-20	dynein axonemal heavy chain 8	Homo sapiens	113-119
8640350-17	1995	These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins.	Phosphatidylcholines	46-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	99-102
8640350-17	1995	These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins.	Phosphatidylcholines	67-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	99-102
8575813-2	1995	The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline.	Phosphatidylcholines	129-149	lecithin cholesterol acyltransferase	Rattus norvegicus	11-48
8575813-2	1995	The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline.	Phosphatidylcholines	129-149	lecithin cholesterol acyltransferase	Rattus norvegicus	50-54
8576100-5	1995	On the other hand, liposomes composed of phosphatidylcholine (PC) showed no increase in permeability when incubated with IL-1 alpha, suggesting the importance of acidic phospholipids in the interaction of IL-1 alpha with the membrane.	Phosphatidylcholines	41-60	interleukin 1 alpha	Homo sapiens	205-215
8578536-9	1995	Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	146-165	phospholipase A2 group IB	Homo sapiens	23-39
8564710-3	1995	Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system.	Phosphatidylcholines	104-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-53
8564710-3	1995	Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system.	Phosphatidylcholines	125-129	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-53
8538377-4	1995	While both L-FABP and I-FABP increased esterification of [3H]-oleic acid into ethanolamine glycerophospholipids, these proteins had opposite effect on esterification into choline glycerophospholipids.	Phosphatidylcholines	171-199	fatty acid binding protein 1, liver	Mus musculus	11-17
8538377-4	1995	While both L-FABP and I-FABP increased esterification of [3H]-oleic acid into ethanolamine glycerophospholipids, these proteins had opposite effect on esterification into choline glycerophospholipids.	Phosphatidylcholines	171-199	fatty acid binding protein 2, intestinal	Mus musculus	22-28
7559399-0	1995	Phosphatidylcholines with sn-1 saturated and sn-2 cis-monounsaturated acyl chains.	Phosphatidylcholines	0-20	solute carrier family 38 member 3	Homo sapiens	26-30
8590265-4	1995	An arachidonoyl-dependent phospholipase A2 is activated to release arachidonic acid from membrane phospholipids, especially phosphatidylcholine and ethanolamine.	Phosphatidylcholines	124-143	phospholipase A2	Oryctolagus cuniculus	26-42
8709678-1	1995	Cytidine 5"-diphosphocholine, CDP-choline or citicoline, is an essential intermediate in the biosynthetic pathway of the structural phospholipids of cell membranes, especially in that of phosphatidylcholine.	Phosphatidylcholines	187-206	natriuretic peptide A	Homo sapiens	30-33
8578536-9	1995	Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	146-165	phospholipase A2 group IB	Homo sapiens	41-45
7559399-12	1995	In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart.	Phosphatidylcholines	112-131	solute carrier family 38 member 3	Homo sapiens	72-76
8578536-9	1995	Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	167-169	phospholipase A2 group IB	Homo sapiens	23-39
7559399-12	1995	In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart.	Phosphatidylcholines	112-131	solute carrier family 38 member 5	Homo sapiens	87-91
7559399-12	1995	In this communication, we also propose that in the gel-state bilayer of sn-1 saturated/sn-2 cis-monounsaturated phosphatidylcholine the entire length of the shorter segment of the sn-2 acyl chain acts as a structural perturbing element; hence, it is mainly responsible for the large lower Tm of the monoenoic lipid relative to the saturated counterpart.	Phosphatidylcholines	112-131	solute carrier family 38 member 5	Homo sapiens	180-184
8578536-9	1995	Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	167-169	phospholipase A2 group IB	Homo sapiens	41-45
8578536-10	1995	Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	95-114	phospholipase A2 group IB	Homo sapiens	9-13
8578536-10	1995	Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%.	Phosphatidylcholines	116-118	phospholipase A2 group IB	Homo sapiens	9-13
7673165-6	1995	These results clearly implicate both Raf-1 and zeta PKC as necessary downstream components for transduction of the mitogenic/oncogenic signal generated by PLC-mediated hydrolysis of phosphatidylcholine and suggest, together with other recent evidence, a bifurcation in the signaling pathway downstream of PC-PLC.	Phosphatidylcholines	182-201	v-raf-leukemia viral oncogene 1	Mus musculus	37-55
7673165-6	1995	These results clearly implicate both Raf-1 and zeta PKC as necessary downstream components for transduction of the mitogenic/oncogenic signal generated by PLC-mediated hydrolysis of phosphatidylcholine and suggest, together with other recent evidence, a bifurcation in the signaling pathway downstream of PC-PLC.	Phosphatidylcholines	182-201	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	155-158
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Phosphatidylcholines	193-212	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Phosphatidylcholines	193-212	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Phosphatidylcholines	214-220	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Phosphatidylcholines	214-220	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
7654192-0	1995	Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry.	Phosphatidylcholines	83-102	cytochrome c oxidase subunit 8A	Homo sapiens	36-40
7654206-4	1995	As observed for PI-TP alpha, PI-TP beta has a distinct preference for phosphatidylinositol over phosphatidylcholine.	Phosphatidylcholines	96-115	phosphatidylinositol transfer protein beta	Bos taurus	29-39
8519996-6	1995	The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation.	Phosphatidylcholines	191-210	proline rich transmembrane protein 2	Homo sapiens	95-111
8519996-6	1995	The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation.	Phosphatidylcholines	191-210	proline rich transmembrane protein 2	Homo sapiens	113-117
8519996-6	1995	The DAG-induced changes in alpha-deuteron splittings were found to correlate with DAG-enhanced protein kinase C (PK-C) activity, suggesting that the DAG-induced conformational changes of the phosphatidylcholine headgroups are either directly or indirectly related to a mechanism of PK-C activation.	Phosphatidylcholines	191-210	proline rich transmembrane protein 2	Homo sapiens	282-286
7650054-8	1995	Moreover, we have demonstrated that the extracellular Ca(2+)-dependent increase in diacylglycerol levels in response to EGF is associated with an increase in extracellular choline release, which is indicative of an activation of a phosphatidylcholine-linked phospholipase D. These results suggest that diacylglycerol sources other than PtdIns"s may be important in the extracellular Ca(2+)-dependent regulation of EGF-mediated cell replication.	Phosphatidylcholines	231-250	epidermal growth factor	Homo sapiens	120-123
7544643-8	1995	These antibodies also inhibited the binding of fVIII to synthetic phospholipid membranes of PS and phosphatidylcholine, confirming that the blocked epitopes contribute to membrane binding as well as binding to PS.	Phosphatidylcholines	99-118	coagulation factor VIII	Homo sapiens	47-52
7650054-8	1995	Moreover, we have demonstrated that the extracellular Ca(2+)-dependent increase in diacylglycerol levels in response to EGF is associated with an increase in extracellular choline release, which is indicative of an activation of a phosphatidylcholine-linked phospholipase D. These results suggest that diacylglycerol sources other than PtdIns"s may be important in the extracellular Ca(2+)-dependent regulation of EGF-mediated cell replication.	Phosphatidylcholines	231-250	epidermal growth factor	Homo sapiens	414-417
7480083-4	1995	The major long-chain polyunsaturated fatty acids (LC-PUFA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are found primarily in PC, PE, and PI.	Phosphatidylcholines	167-169	pumilio RNA binding family member 3	Homo sapiens	53-57
7657619-6	1995	This was verified by demonstrating that the phospholipids, phosphatidylcholine and phosphatidylinositol, were hydrolyzed to glycerophosphocholine and glycerophosphoinositol by incubation with recombinant 85-kDa PLA2.	Phosphatidylcholines	59-78	phospholipase A2, group IB, pancreas	Mus musculus	211-215
7545008-9	1995	At a given lipase concentration in the water subphase, the interfacial binding of HGL to the nonhydrolyzable egg yolk phosphatidylcholine (egg PC) monolayers was found to be 10 times lower than that in the case of dicaprin monolayers.	Phosphatidylcholines	118-137	lipase F, gastric type	Homo sapiens	82-85
7650001-4	1995	The partition coefficient, Kp, describing the affinity of myristoylated MRP for acidic lipid vesicles (20% phosphatidylserine, 80% phosphatidylcholine) is 5-8 x 10(3) M-1, which is only 2-4 times larger than the partition coefficient for the unmyristoylated protein.	Phosphatidylcholines	131-150	MARCKS-like 1	Mus musculus	72-75
7650001-9	1995	Since only a marginal binding could be observed with neutral phosphatidylcholine vesicles, we propose that electrostatic interactions are the major determinant of the binding of MRP to pure lipid membranes.	Phosphatidylcholines	61-80	MARCKS-like 1	Mus musculus	178-181
7616250-6	1995	When the oral CDP-choline treatment was prolonged for 42 and 90 days, brain phosphatidylcholine concentrations increased significantly (by 22-25%; p &lt; 0.05) in rats consuming 500 mg/kg/day.	Phosphatidylcholines	76-95	cut-like homeobox 1	Rattus norvegicus	14-17
8562872-4	1995	The activity of the phospholipid-free, detergent-solubilized enzyme was almost fully restored by phosphatidyl serine (PS) and its sensitivity to calmodulin was restored in the presence of phosphatidyl choline (PC).	Phosphatidylcholines	188-208	calmodulin 1	Homo sapiens	145-155
8562872-4	1995	The activity of the phospholipid-free, detergent-solubilized enzyme was almost fully restored by phosphatidyl serine (PS) and its sensitivity to calmodulin was restored in the presence of phosphatidyl choline (PC).	Phosphatidylcholines	210-212	calmodulin 1	Homo sapiens	145-155
8588979-4	1995	This suggests that a synergistic involvement of phosphatidylinositol-bis-phosphate (PIP2) hydrolysis and phosphatidylcholine (PC) breakdown provide early molecular events upon the interaction between interferon beta and its cell surface receptors.	Phosphatidylcholines	105-124	interferon beta 1	Homo sapiens	200-215
8588979-4	1995	This suggests that a synergistic involvement of phosphatidylinositol-bis-phosphate (PIP2) hydrolysis and phosphatidylcholine (PC) breakdown provide early molecular events upon the interaction between interferon beta and its cell surface receptors.	Phosphatidylcholines	126-128	interferon beta 1	Homo sapiens	200-215
7631805-9	1995	This form of PLA2 exhibited a neutral and broad pH optimum (pH 6.0-8.0) and hydrolyzed both phosphatidylethanolamine and phosphatidylcholine effectively.	Phosphatidylcholines	121-140	phospholipase A2 group IB	Homo sapiens	13-17
7579706-4	1995	Also, phospholipase D activity, estimated by the production of phosphatidylethanol from phosphatidylcholine in the presence of ethanol, was stimulated by GnRH but not ET-1.	Phosphatidylcholines	88-107	gonadotropin releasing hormone 1	Homo sapiens	154-158
7477743-3	1995	Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis.	Phosphatidylcholines	143-162	cut like homeobox 1	Homo sapiens	28-31
7481876-5	1995	Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding.	Phosphatidylcholines	167-186	phospholipase A2 group IB	Rattus norvegicus	56-72
7481876-5	1995	Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding.	Phosphatidylcholines	188-190	phospholipase A2 group IB	Rattus norvegicus	56-72
7542869-3	1995	We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates.	Phosphatidylcholines	151-170	serum amyloid A1	Homo sapiens	35-38
7542869-3	1995	We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates.	Phosphatidylcholines	151-170	phospholipase A2 group X	Homo sapiens	115-120
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	126-145	interleukin 1 alpha	Mus musculus	0-19
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	126-145	interleukin 1 alpha	Mus musculus	21-30
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	126-145	tumor necrosis factor	Mus musculus	36-63
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	126-145	tumor necrosis factor	Mus musculus	65-74
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	147-149	interleukin 1 alpha	Mus musculus	0-19
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	147-149	interleukin 1 alpha	Mus musculus	21-30
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	147-149	tumor necrosis factor	Mus musculus	36-63
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylcholines	147-149	tumor necrosis factor	Mus musculus	65-74
8537301-3	1995	We found that at neutral pH and low ionic strength, beta 2-GPI became bound to liposome membranes containing cardiolipin, phosphatidylglycerol, phosphatidylserine, phosphatidylserine, phosphatidic acid, or phosphatidylinositol, but not phosphatidylcholine alone.	Phosphatidylcholines	236-255	apolipoprotein H	Bos taurus	52-62
7551690-5	1995	Codispersion with the semi-synthetic phosphatidylcholine of cholesterol or unsaturated fluid lecithin modulated both excimer formation and the susceptibility of the fluorescent probe to hydrolysis by venom phospholipase A2 at 22 degrees C. Similar results were obtained with hydrolysis of a radiolabelled substrate, 1-palmitoyl-sn-2-[1-14C]linoleoylphosphatidylethanolamine, codispersed with the semi-synthetic phosphatidylcholine.	Phosphatidylcholines	411-430	phospholipase A2 group IB	Rattus norvegicus	206-222
7615839-3	1995	With fibroblasts from normal subjects, purified apo A-I cleared cells of cholesteryl esters, depleted cellular free cholesterol pools available for esterification, and stimulated efflux of radiolabeled cholesterol, phosphatidylcholine, and sphingomyelin.	Phosphatidylcholines	215-234	apolipoprotein A1	Homo sapiens	48-55
7564919-4	1995	We find that both GM-CSF and SLF induced increased phosphatidylcholine (PC) turnover rates (biosynthesis and degradation) as measured by increased [3H]-choline labelling, with SLF being more potent than GM-CSF after 6 h of stimulation, but equipotent at 24 h of stimulation.	Phosphatidylcholines	51-70	colony stimulating factor 2	Homo sapiens	18-24
7551686-3	1995	Plasma phospholipids demonstrated three distinct PAF inhibitory fractions in TLC regions corresponding to those of sphingomyelin, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	130-149	PCNA clamp associated factor	Homo sapiens	49-52
7551690-5	1995	Codispersion with the semi-synthetic phosphatidylcholine of cholesterol or unsaturated fluid lecithin modulated both excimer formation and the susceptibility of the fluorescent probe to hydrolysis by venom phospholipase A2 at 22 degrees C. Similar results were obtained with hydrolysis of a radiolabelled substrate, 1-palmitoyl-sn-2-[1-14C]linoleoylphosphatidylethanolamine, codispersed with the semi-synthetic phosphatidylcholine.	Phosphatidylcholines	37-56	phospholipase A2 group IB	Rattus norvegicus	206-222
7564919-4	1995	We find that both GM-CSF and SLF induced increased phosphatidylcholine (PC) turnover rates (biosynthesis and degradation) as measured by increased [3H]-choline labelling, with SLF being more potent than GM-CSF after 6 h of stimulation, but equipotent at 24 h of stimulation.	Phosphatidylcholines	51-70	KIT ligand	Homo sapiens	29-32
7626201-0	1995	Transmembrane Ca2+ gradient-mediated phosphatidylcholine modulating sarcoplasmic reticulum C(a2+)-ATPase.	Phosphatidylcholines	37-56	dynein axonemal heavy chain 8	Homo sapiens	98-104
8524695-6	1995	Decreased phosphatidylethanolamine, phosphatidylinositol and phosphatidylcholine levels were shown in patients before EPO treatment, compares with the control group.	Phosphatidylcholines	61-80	erythropoietin	Homo sapiens	118-121
7794891-1	1995	The recombinant human 85-kDa cytosolic phospholipase A2 (cPLA2), when assayed in the presence of glycerol, catalyzes the transfer of acyl chains of radiolabeled phosphatidylcholine and para-substituted phenyl esters of fatty acids to glycerol, in addition to hydrolyzing these substrates.	Phosphatidylcholines	161-180	phospholipase A2 group IVA	Homo sapiens	57-62
7647244-1	1995	Solid-state 2H nuclear magnetic resonance spectroscopy was used to determine the orientational order parameter profiles for a series of phosphatidylcholines with perdeuterated stearic acid, 18:0d35, in position sn-1 and 18:1 omega 9, 18:2 omega 6, 18:3 omega 3, 20:4 omega 6, 20:5 omega 3, or 22:6 omega 3 in position sn-2.	Phosphatidylcholines	136-156	solute carrier family 38 member 3	Homo sapiens	211-288
7794891-8	1995	Thus, cPLA2 has phospholipase A1 activity but only if an ether linkage rather than an ester linkage is present at the sn-2 position, and it is shown that the sn-1 acyl chains of both enantiomers of phosphatidylcholine are hydrolyzed.	Phosphatidylcholines	198-217	phospholipase A2 group IVA	Homo sapiens	6-11
7768909-3	1995	The chemotactic peptide fMLP and the phorbol ester, phorbol 12-myristate 13-acetate, are known to stimulate phosphatidylcholine degradation by phospholipase D in human neutrophils.	Phosphatidylcholines	108-127	formyl peptide receptor 1	Homo sapiens	24-28
7768909-4	1995	fMLP alone triggered phosphatidylcholine breakdown into phosphatidic acid, but did not stimulate phosphatidylcholine synthesis or activation of the rate-limiting enzyme CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	21-40	formyl peptide receptor 1	Homo sapiens	0-4
7768909-5	1995	Adding cytochalasin B to fMLP led to some conversion of phosphatidic acid into diglyceride, and fMLP was then able to trigger choline incorporation into phosphatidylcholine, and cytidylyltransferase translocation from cytosol to membranes.	Phosphatidylcholines	153-172	formyl peptide receptor 1	Homo sapiens	96-100
7772034-4	1995	The presence of certain membrane-bound anions can enhance hydrolysis of PC by the mammalian secreted PLA2S.	Phosphatidylcholines	72-74	phospholipase A2 group IIA	Homo sapiens	101-106
7626201-2	1995	The role of phospholipids, especially phosphatidylcholine (PC), in the modulation of C(a2+)-ATPase by transmembrane Ca2+ gradient was investigated.	Phosphatidylcholines	59-61	dynein axonemal heavy chain 8	Homo sapiens	92-98
7626201-4	1995	(i) Incubated with phospholipids, the enzyme activity of the delipidated C(a2+)-ATPase is inhibited by Ca2+ and the highest inhibition is observed in the presence of PC.	Phosphatidylcholines	166-168	dynein axonemal heavy chain 8	Homo sapiens	80-86
7758586-1	1995	Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF.	Phosphatidylcholines	12-31	nerve growth factor	Homo sapiens	117-136
7744831-1	1995	In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I.	Phosphatidylcholines	196-216	lecithin-cholesterol acyltransferase	Homo sapiens	22-58
7744831-1	1995	In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I.	Phosphatidylcholines	196-216	lecithin-cholesterol acyltransferase	Homo sapiens	60-64
7744831-5	1995	When DBP preparations containing 27-hydroxycholesterol and various phosphatidylcholines were used for the LCAT reaction, both monoesters and diesters were produced.	Phosphatidylcholines	67-87	lecithin-cholesterol acyltransferase	Homo sapiens	106-110
7758577-2	1995	Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho).	Phosphatidylcholines	80-99	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
7758577-2	1995	Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho).	Phosphatidylcholines	101-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
7758586-1	1995	Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF.	Phosphatidylcholines	12-31	nerve growth factor	Homo sapiens	138-141
7758586-1	1995	Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF.	Phosphatidylcholines	12-31	nerve growth factor	Homo sapiens	180-183
7766652-11	1995	Both cPLA2 and cPLA2S505A were purified from infected Sf9 cells and the specific activity for each of the enzymes was measured in a phosphatidylcholine vesicle fluorescence assay using 1-(10-pyrenedecanyl)arachidonyl-sn-glycero-3-phosphocholine as substrate.	Phosphatidylcholines	132-151	phospholipase A2 group IVA	Homo sapiens	5-10
7762680-8	1995	Phosphatidylcholine was rapidly degraded by macrophages and the degradation occurred both in the presence and absence of SP-A.	Phosphatidylcholines	0-19	surfactant protein A1	Homo sapiens	121-125
7538427-4	1995	VCAM-1 induction is regulated by activation of nuclear factor-kappa B, which can be mediated by a TNF-alpha-responsive phosphatidylcholine-specific phospholipase C (PC-PLC).	Phosphatidylcholines	119-138	vascular cell adhesion molecule 1	Homo sapiens	0-6
7538427-4	1995	VCAM-1 induction is regulated by activation of nuclear factor-kappa B, which can be mediated by a TNF-alpha-responsive phosphatidylcholine-specific phospholipase C (PC-PLC).	Phosphatidylcholines	119-138	tumor necrosis factor	Homo sapiens	98-107
7538076-5	1995	PAF is an acetylated derivative of phosphatidylcholine which is produced by EC and may act in an autocrine manner.	Phosphatidylcholines	35-54	PCNA clamp associated factor	Homo sapiens	0-3
7742350-6	1995	We concluded that the delta 6-desaturase has an associated lipid surrounding of PC and cholesterol at an approx.	Phosphatidylcholines	80-82	fatty acid desaturase 2	Rattus norvegicus	22-40
7551680-4	1995	Phosphatidylcholine and sphingomyelin were found to be the most effective activators of protein kinase A and tyrosine kinase.	Phosphatidylcholines	0-19	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	88-104
7702604-0	1995	A novel phosphatidylcholine hydrolysing action of C-reactive protein.	Phosphatidylcholines	8-27	C-reactive protein	Rattus norvegicus	50-68
7721742-3	1995	GTP gamma S-stimulated PLD activity was detected in the membranes when exogenous labeled phosphatidylcholine was used in the presence of phosphatidylethanolamine and phosphatidylinositol 4,5-bisphosphate, but not when [3H]myristic acid-labeled endogenous substrate was used.	Phosphatidylcholines	89-108	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	23-26
7703251-2	1995	Overnight treatment with either PC or SM liposomes causes a substantial enhancement of antigen-stimulated degranulation and phospholipase A2 activity, whereas treatment with a PC/chol mixture results in partial inhibition of the antigen-stimulated response.	Phosphatidylcholines	32-34	phospholipase A2 group IB	Rattus norvegicus	124-140
7703252-4	1995	The reactivity of the apoA-I-pre-beta-HDL particles with LCAT was in the same order as that in human plasma HDL and in phosphatidylcholine/cholesterol unilamellar vesicles activated by apoA-I when compared on the rate of percent cholesterol esterification.	Phosphatidylcholines	119-138	apolipoprotein A1	Homo sapiens	22-28
7703252-4	1995	The reactivity of the apoA-I-pre-beta-HDL particles with LCAT was in the same order as that in human plasma HDL and in phosphatidylcholine/cholesterol unilamellar vesicles activated by apoA-I when compared on the rate of percent cholesterol esterification.	Phosphatidylcholines	119-138	apolipoprotein A1	Homo sapiens	185-191
7696254-3	1995	Acyl-labeled N-4-nitrobenzo-2-oxa-1,3-diazole (NBD) -phosphatidylcholine (-PC), -phosphatidylethanolamine (-PE), or -phosphatidylserine (-PS) were incorporated into sperm cells, and the transbilayer location was determined by extraction of probe from cell with excess bovine serum albumin (BSA) or by chemical destruction of probe by sodium dithionite.	Phosphatidylcholines	53-72	albumin	Homo sapiens	275-288
8846880-3	1995	The results showed that CT Vc5 inhibits PLA2 activity on phosphatidylcholine liposomes.	Phosphatidylcholines	57-76	phospholipase A2 group IB	Homo sapiens	40-44
7626245-8	1995	The peptide was confined to the bilayer headgroup/water region, similar to that reported from neutron diffraction measurement of tripeptides bound to the phosphatidylcholine bilayer surface (Ref 1).	Phosphatidylcholines	154-173	tissue factor pathway inhibitor 2	Homo sapiens	191-196
7532666-8	1995	These findings support the idea that the human MIP-1 alpha receptor is coupled to phospholipid and cAMP metabolism in a manner similar to other 7-transmembrane, G-protein-linked receptors and suggest that a phosphatidylcholine hydrolytic cycle and an associated increase in cAMP are part of the mechanisms of action of MIP-1 alpha.	Phosphatidylcholines	207-226	C-C motif chemokine ligand 3	Homo sapiens	47-58
7706325-0	1995	Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step.	Phosphatidylcholines	4-23	cut-like homeobox 1	Mus musculus	94-97
7706325-0	1995	Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step.	Phosphatidylcholines	4-23	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	154-193
7896791-7	1995	Addition of one acyl chain from diglyceride to triglyceride, lysophosphatidylcholine to phosphatidylcholine, or cholesterol to cholesteryl ester increased the rate of MTP-mediated transport 10-fold.	Phosphatidylcholines	65-84	microsomal triglyceride transfer protein	Homo sapiens	167-170
7576493-1	1995	In the present study, we examined the effect of vasopressin (AVP) on phosphatidylcholine-hydrolyzing phospholipase D activity in primary cultured rat aortic smooth muscle cells.	Phosphatidylcholines	69-88	arginine vasopressin	Rattus norvegicus	48-59
7532666-0	1995	Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.	Phosphatidylcholines	74-93	C-C motif chemokine ligand 3	Homo sapiens	0-39
7532666-4	1995	We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly.	Phosphatidylcholines	249-268	C-C motif chemokine ligand 3	Homo sapiens	115-126
7893681-0	1995	Effect of cholesterol, fatty acyl chain composition, and bilayer curvature on the interaction of cytochrome b5 with liposomes of phosphatidylcholines.	Phosphatidylcholines	129-149	cytochrome b5 type A	Homo sapiens	97-110
7532666-4	1995	We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly.	Phosphatidylcholines	249-268	C-C motif chemokine ligand 3	Homo sapiens	168-179
7876145-7	1995	The inhibitor also enhanced EGF-stimulated [3H]diacylglycerol formation in cells preincubated with [3H]arachidonic acid, which labeled predominantly phosphatidylinositol, but inhibited [3H]diacylglycerol production in cells preincubated with [3H]myristic acid, which labeled mainly phosphatidylcholine.	Phosphatidylcholines	282-301	epidermal growth factor	Mus musculus	28-31
7532666-4	1995	We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly.	Phosphatidylcholines	270-272	C-C motif chemokine ligand 3	Homo sapiens	115-126
7532666-4	1995	We show here that the human factor-dependent cell line M07e is responsive to the cell cycle-suppressive effects of MIP-1 alpha, has specific membrane-binding sites for MIP-1 alpha, and that treatment of these cells with this chemokine increases the phosphatidylcholine (PC) and phosphocholine turnover rates in cells that are synergistically stimulated by the combination of granulocyte-macrophage colony-stimulating factor and steel factor but not these factors acting singly.	Phosphatidylcholines	270-272	C-C motif chemokine ligand 3	Homo sapiens	168-179
7532666-6	1995	Both exogenous PC and dibutyryl cAMP were found to suppress the proliferation of M07e colony-forming cells to a level similar to that of MIP-1 alpha, further implicating cAMP and PC metabolism in MIP-1 alpha-induced M07e suppression.	Phosphatidylcholines	15-17	C-C motif chemokine ligand 3	Homo sapiens	196-207
7876145-8	1995	These data support the conclusion that EGF can stimulate diacylglycerol formation from PtdIns(4,5)P2 and that PKC performs the dual role of down-regulating this response as well as mediating phosphatidylcholine hydrolysis.	Phosphatidylcholines	191-210	epidermal growth factor	Mus musculus	39-42
7876145-8	1995	These data support the conclusion that EGF can stimulate diacylglycerol formation from PtdIns(4,5)P2 and that PKC performs the dual role of down-regulating this response as well as mediating phosphatidylcholine hydrolysis.	Phosphatidylcholines	191-210	protein kinase C, alpha	Mus musculus	110-113
7857976-1	1995	The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	66-82
7836750-0	1995	Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells.	Phosphatidylcholines	50-69	interleukin 3	Homo sapiens	6-10
7836750-14	1995	These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction.	Phosphatidylcholines	203-222	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-64
7836750-14	1995	These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction.	Phosphatidylcholines	203-222	interleukin 3	Homo sapiens	78-82
7836750-14	1995	These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction.	Phosphatidylcholines	203-222	interleukin 3 receptor subunit alpha	Homo sapiens	196-201
7836750-14	1995	These data, combined with our previous report showing that c-jun induction by IL-3 is dependent on protein kinase C, suggest that, in hematopoietic and nonhematopoietic cells expressing the human IL-3R, phosphatidylcholine hydrolysis and protein kinase C are downstream effectors of tyrosine phosphorylation in the IL-3 signal transduction cascade resulting in immediate early response gene induction.	Phosphatidylcholines	203-222	interleukin 3	Homo sapiens	196-200
7857976-1	1995	The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC).	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	84-88
7857307-4	1995	As a potent inhibitor of S-adenosylhomocysteine hydrolase, aristeromycin inhibited methylation of phosphatidylethanolamine to form phosphatidylcholine in K562 cells.	Phosphatidylcholines	131-150	adenosylhomocysteinase	Homo sapiens	25-57
7751812-4	1995	In low density lipoprotein (LDL) and high density lipoprotein-3 (HDL3) the fluorescent PC analog showed only monomer fluorescence, whereas in Lp[a] and HDL2 monomer and excimer fluorescence were observed, indicating that the fluorescent phosphatidylcholine analog was incorporated into the respective lipoproteins to a different extent.	Phosphatidylcholines	87-89	HDL3	Homo sapiens	37-63
7864076-1	1995	Previous studies from this laboratory have shown that in cultured rat mesangial cells (MC), angiotensin II (ANG II) mediates its effects via activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PC-PLD).	Phosphatidylcholines	214-233	angiotensinogen	Rattus norvegicus	92-106
7864076-1	1995	Previous studies from this laboratory have shown that in cultured rat mesangial cells (MC), angiotensin II (ANG II) mediates its effects via activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PC-PLD).	Phosphatidylcholines	214-233	angiotensinogen	Rattus norvegicus	108-114
8529867-1	1995	Monohydrochloride of [2-(decyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C10A) has a biphasic effect on the fluidity of egg yolk phosphatidylcholine (EYPC) model membranes as detected by the methyl ester of stearic acid spin probe, with the paramagnetic doxyl group bound to C-16.	Phosphatidylcholines	145-164	endogenous retrovirus group K member 16	Homo sapiens	89-93
7751812-13	1995	The use of a fluorescent dialkyl- instead of diacyl-glycerophosphocholine for transfer studies was mandatory, as we found that lipoproteins contained phospholipase A2 activity toward long-chain phosphatidylcholine.	Phosphatidylcholines	194-213	phospholipase A2 group IB	Homo sapiens	150-166
7751812-4	1995	In low density lipoprotein (LDL) and high density lipoprotein-3 (HDL3) the fluorescent PC analog showed only monomer fluorescence, whereas in Lp[a] and HDL2 monomer and excimer fluorescence were observed, indicating that the fluorescent phosphatidylcholine analog was incorporated into the respective lipoproteins to a different extent.	Phosphatidylcholines	87-89	HDL3	Homo sapiens	65-69
7757108-3	1995	We found that at neutral pH and low ionic strength beta 2-GPI bound to liposome membranes containing cardiolipin with a dissociation constant (Kd) of 10(-8) M. Phosphatidylglycerol, phosphatidylserine, phosphatidic acid or phosphatidylinositol bound to beta 2-GPI, but phosphatidylcholine did not.	Phosphatidylcholines	269-288	apolipoprotein H	Bos taurus	51-61
7751815-8	1995	The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P &lt; 0.0001).	Phosphatidylcholines	116-118	phosphatidylcholine-sterol acyltransferase	Macaca fascicularis	30-66
7751815-8	1995	The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P &lt; 0.0001).	Phosphatidylcholines	116-118	phosphatidylcholine-sterol acyltransferase	Macaca fascicularis	68-72
7751815-8	1995	The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P &lt; 0.0001).	Phosphatidylcholines	169-171	phosphatidylcholine-sterol acyltransferase	Macaca fascicularis	30-66
7751815-8	1995	The reaction rate of purified lecithin:cholesterol acyltransferase (LCAT) with particles made from n-3 Poly-derived PC was 50% of that determined using rHDL formed with PC from other dietary groups (P &lt; 0.0001).	Phosphatidylcholines	169-171	phosphatidylcholine-sterol acyltransferase	Macaca fascicularis	68-72
7751815-9	1995	When the distribution of LCAT-derived rHDL cholesteryl esters was analyzed, LCAT demonstrated little selectivity for certain PC molecular species except in n-3 Poly-derived rHDL where 18:2-containing PC was selectively utilized.	Phosphatidylcholines	125-127	phosphatidylcholine-sterol acyltransferase	Macaca fascicularis	76-80
7784893-1	1995	Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid.	Phosphatidylcholines	190-209	phospholipase A2 group IB	Rattus norvegicus	58-74
7784893-1	1995	Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid.	Phosphatidylcholines	190-209	phospholipase A2 group IB	Rattus norvegicus	76-80
7493735-0	1995	[Phosphatidylcholine induces an increase in the production of interleukin-6 and improves survival of rats with neonatal sepsis caused by Klebsiella pneumoniae].	Phosphatidylcholines	1-20	interleukin 6	Rattus norvegicus	62-75
7836412-1	1995	Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	192-211	cholecystokinin	Rattus norvegicus	48-63
7836412-1	1995	Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	192-211	cholecystokinin	Rattus norvegicus	65-68
7836412-1	1995	Stimulation of rat pancreatic acinar cells with cholecystokinin (CCK) is known to result in a significant inhibition of CTP:phosphocholine cytidylyltransferase (CT), a rate-limiting enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	192-211	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	120-159
7832781-8	1995	This concentration of PMA significantly increased [14C]PtdCho levels in both control and PKC alpha-over-expressing lines, although the effect in the latter was significantly greater.	Phosphatidylcholines	55-61	protein kinase C, alpha	Mus musculus	89-98
7832781-11	1995	Although additional PKC subtypes appear to participate in the control of PtdCho synthesis in these cells, PMA-stimulated choline uptake in Swiss 3T3 fibroblasts is almost entirely dependent on the presence of PKC alpha.	Phosphatidylcholines	73-79	protein kinase C, alpha	Mus musculus	20-23
7814396-1	1995	CTP:phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells.	Phosphatidylcholines	77-96	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
7816798-6	1995	Finally, whereas the SEC14p-dependent inhibition of CCTase in vitro was markedly reduced under assay conditions that were expected to increase levels of phosphatidylinositol-bound SEC14p, assay conditions expected to increase levels of phosphatidylcholine-bound SEC14p resulted in significant potentiation of CCTase inhibition.	Phosphatidylcholines	236-255	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	21-27
7816798-6	1995	Finally, whereas the SEC14p-dependent inhibition of CCTase in vitro was markedly reduced under assay conditions that were expected to increase levels of phosphatidylinositol-bound SEC14p, assay conditions expected to increase levels of phosphatidylcholine-bound SEC14p resulted in significant potentiation of CCTase inhibition.	Phosphatidylcholines	236-255	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	52-58
7816798-7	1995	The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled.	Phosphatidylcholines	37-56	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	71-77
7816798-7	1995	The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled.	Phosphatidylcholines	37-56	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	175-181
7816798-7	1995	The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled.	Phosphatidylcholines	37-56	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	237-243
7816798-7	1995	The collective data suggest that the phosphatidylcholine-bound form of SEC14p effects an essential repression of CDP-choline pathway activity in Golgi membranes by inhibiting CCTase and that the phospholipid-binding/exchange activity of SEC14p represents a mechanism by which the regulatory activity of SEC14p is itself controlled.	Phosphatidylcholines	37-56	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	237-243
7893853-2	1995	In cholinergic neurons PLA2 controls the physico-chemical properties of neuronal membranes as well as the breakdown of phosphatidylcholine to produce choline for acetylcholine synthesis.	Phosphatidylcholines	119-138	phospholipase A2 group IB	Homo sapiens	23-27
7798907-8	1995	The purified PLA2 displays a preference for phosphatidylcholine as a substrate but hydrolyzes phospholipid substrates with arachidonic acid or linoleic acid esterified at the sn-2 position to the same extent.	Phosphatidylcholines	44-63	LOC104974671	Bos taurus	13-17
7559741-6	1995	The purified P-glycoprotein was reconstituted by detergent dialysis into liposomes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine.	Phosphatidylcholines	95-114	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
8725048-3	1995	The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate.	Phosphatidylcholines	127-129	phospholipase A2 group IB	Rattus norvegicus	16-32
8725048-3	1995	The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate.	Phosphatidylcholines	127-129	phospholipase A2 group IB	Rattus norvegicus	34-38
7799956-8	1995	Treatment with the phosphatidylcholine-specific phospholipase C inhibitor D609 suppressed LPS-mediated, but not CSF-1-mediated, activation of Raf-1, MEK, and MAPK.	Phosphatidylcholines	19-38	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	142-147
7869846-2	1995	As the product of the rate-limiting step in the synthesis of phosphatidylcholine from choline, CDP-choline and its hydrolysis products (cytidine and choline) play important roles in generation of phospholipids involved in membrane formation and repair.	Phosphatidylcholines	61-80	cut like homeobox 1	Homo sapiens	95-98
7799956-8	1995	Treatment with the phosphatidylcholine-specific phospholipase C inhibitor D609 suppressed LPS-mediated, but not CSF-1-mediated, activation of Raf-1, MEK, and MAPK.	Phosphatidylcholines	19-38	mitogen-activated protein kinase kinase 7	Homo sapiens	149-152
7998998-1	1994	Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem.	Phosphatidylcholines	143-162	kininogen 1	Homo sapiens	0-10
7899461-1	1995	The involvement of phospholipase D (PLD) in phosphatidylcholine hydrolysis by epidermal (EGF), insulin-like (IGF-I), and basic fibroblast (bFGF) growth factors was investigated in rat pancreatic acini.	Phosphatidylcholines	44-63	epidermal growth factor	Rattus norvegicus	89-92
7899461-1	1995	The involvement of phospholipase D (PLD) in phosphatidylcholine hydrolysis by epidermal (EGF), insulin-like (IGF-I), and basic fibroblast (bFGF) growth factors was investigated in rat pancreatic acini.	Phosphatidylcholines	44-63	insulin-like growth factor 1	Rattus norvegicus	95-114
7539565-0	1995	[The effect of phosphatidylcholine on repair processes in liver cells in acute CCl4 damage].	Phosphatidylcholines	15-34	C-C motif chemokine ligand 4	Rattus norvegicus	79-83
7539565-1	1995	Effect of phosphatidylcholine, isolated from soy beans and sunflower seeds for laboratory use, on synthesis of RNA, DNA, albumin and content of newly synthesized mRNA in polyribosomes was studied in hepatocytes after chemical hepatectomy produced by single administration of CCl4 into rats; histological and histochemical studies of liver tissue were also carried out.	Phosphatidylcholines	10-29	C-C motif chemokine ligand 4	Rattus norvegicus	275-279
7527658-1	1994	The effect of bovine myelin basic protein (MBP) on dimyristoylphosphatidic acid (DMPA) and phosphatidic acid prepared from egg yolk phosphatidylcholine (EPA) has been investigated by transmission and attenuated total reflectance (ATR) Fourier transform infrared spectroscopy.	Phosphatidylcholines	132-151	myelin basic protein	Bos taurus	21-41
7527658-1	1994	The effect of bovine myelin basic protein (MBP) on dimyristoylphosphatidic acid (DMPA) and phosphatidic acid prepared from egg yolk phosphatidylcholine (EPA) has been investigated by transmission and attenuated total reflectance (ATR) Fourier transform infrared spectroscopy.	Phosphatidylcholines	132-151	myelin basic protein	Bos taurus	43-46
7527558-3	1994	Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles.	Phosphatidylcholines	117-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
7527558-3	1994	Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles.	Phosphatidylcholines	138-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylcholines	88-90	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-22
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylcholines	88-90	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylcholines	163-165	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-22
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylcholines	163-165	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
7811715-0	1994	Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activity.	Phosphatidylcholines	37-56	arachidonate 5-lipoxygenase	Homo sapiens	6-20
7811715-1	1994	A Ca2+ and a phosphatidylcholine (PC) as stimulatory factors to human 5-lipoxygenase (5-LO) were assessed to examine aspects of the regulatory mechanism of 5-LO.	Phosphatidylcholines	34-36	arachidonate 5-lipoxygenase	Homo sapiens	70-84
7803401-4	1994	MTP was incubated with donor phosphatidylcholine vesicles of varying neutral lipid composition.	Phosphatidylcholines	29-48	microsomal triglyceride transfer protein	Homo sapiens	0-3
7803401-7	1994	Using phosphatidylcholine emulsions containing 60 mol % triolein as the donor particles resulted in only a slight increase in triolein binding to MTP.	Phosphatidylcholines	6-25	microsomal triglyceride transfer protein	Homo sapiens	146-149
7989342-6	1994	Instead, CSF-1 enhanced the rate of exogenous arachidonic acid incorporation into phosphatidylcholine and its subsequent transfer to phosphatidylethanolamine suggesting that higher rates of arachidonic acid acylation may contribute to the suppression of prostaglandin production.	Phosphatidylcholines	82-101	colony stimulating factor 1 (macrophage)	Mus musculus	9-14
7998990-5	1994	Ang II also caused the hydrolysis of phosphatidylinositol and phosphatidylcholine, the formation of phosphatidic acid and the formation of phosphatidylethanol (PEt) in the presence of ethanol, through activation of a PLD and a PLD-induced transphosphatidylation reaction.	Phosphatidylcholines	62-81	angiotensinogen	Rattus norvegicus	0-6
7998994-0	1994	Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines.	Phosphatidylcholines	112-132	dynein axonemal heavy chain 8	Homo sapiens	65-71
7998998-1	1994	Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem.	Phosphatidylcholines	143-162	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-112
7998998-1	1994	Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem.	Phosphatidylcholines	143-162	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	114-117
7988135-21	1994	CONCLUSIONS: a) TNF-alpha alters the amounts of phosphatidylcholine, phosphatidylinositol, and possibly phosphatidylglycerol present in the lavage-accessible space of the isolated perfused rat lung.	Phosphatidylcholines	48-67	tumor necrosis factor	Rattus norvegicus	16-25
7964753-9	1994	Of these proteins, only MARCKS appears to be correlated with phorbol ester stimulation of phosphatidylcholine turnover in these cells.	Phosphatidylcholines	90-109	myristoylated alanine rich protein kinase C substrate	Homo sapiens	24-30
7731062-0	1994	Selective activation by atrial natriuretic factor of phosphatidylcholine-specific phospholipase activities in purified heart muscle plasma membranes.	Phosphatidylcholines	53-72	natriuretic peptide A	Rattus norvegicus	24-49
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	0-2	superoxide dismutase 1	Homo sapiens	132-135
7947780-1	1994	Surface plasmon resonance (SPR) spectroscopy has been used to follow incorporation and light-induced conformational changes in bovine rhodopsin reconstituted into an egg phosphatidylcholine bilayer deposited on a thin silver film.	Phosphatidylcholines	170-189	rhodopsin	Bos taurus	134-143
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	34-53	superoxide dismutase 1	Homo sapiens	3-6
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	34-53	superoxide dismutase 1	Homo sapiens	132-135
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	34-53	superoxide dismutase 1	Homo sapiens	132-135
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	0-2	superoxide dismutase 1	Homo sapiens	3-6
7996483-2	1994	PC-SOD, in which 4 molecules of a phosphatidylcholine (PC) derivative were covalently bound to each dimer of recombinant human CuZn-SOD (rhCuZn-SOD), was shown to have a high membrane affinity using a laser confocal imaging technique.	Phosphatidylcholines	0-2	superoxide dismutase 1	Homo sapiens	132-135
7961983-3	1994	Lecithin:cholesterol acyltransferase (LCAT) cofactor function, measured as cholesterol esterification occurring when t-apo-phosphatidylcholine-cholesterol complexes were incubated with purified enzyme, decreased significantly when pairs of repeats between residues 117 and 248 were deleted and most markedly when residues 117-160 were deleted.	Phosphatidylcholines	123-142	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
7961983-3	1994	Lecithin:cholesterol acyltransferase (LCAT) cofactor function, measured as cholesterol esterification occurring when t-apo-phosphatidylcholine-cholesterol complexes were incubated with purified enzyme, decreased significantly when pairs of repeats between residues 117 and 248 were deleted and most markedly when residues 117-160 were deleted.	Phosphatidylcholines	123-142	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	257-259	lecithin-cholesterol acyltransferase	Homo sapiens	22-58
7947996-0	1994	Sodium oleate-facilitated reassembly of apolipoprotein A-I with phosphatidylcholine.	Phosphatidylcholines	64-83	apolipoprotein A1	Homo sapiens	40-58
7961831-2	1994	Incorporation of 32Pi into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in wild type and ept1 strains was decreased in the presence of exogenous inositol.	Phosphatidylcholines	27-46	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	114-118
7947996-1	1994	The influence of sodium oleate (oleate) on complexing of apolipoprotein A-I (apo A-I) with egg yolk phosphatidylcholine (EYPC) was evaluated.	Phosphatidylcholines	100-119	apolipoprotein A1	Homo sapiens	57-75
7947996-1	1994	The influence of sodium oleate (oleate) on complexing of apolipoprotein A-I (apo A-I) with egg yolk phosphatidylcholine (EYPC) was evaluated.	Phosphatidylcholines	100-119	apolipoprotein A1	Homo sapiens	77-84
7947997-2	1994	Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE.	Phosphatidylcholines	100-119	lecithin-cholesterol acyltransferase	Homo sapiens	6-42
7947997-2	1994	Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE.	Phosphatidylcholines	100-119	lecithin-cholesterol acyltransferase	Homo sapiens	44-48
7947997-2	1994	Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE.	Phosphatidylcholines	121-123	lecithin-cholesterol acyltransferase	Homo sapiens	6-42
7947997-2	1994	Human lecithin-cholesterol acyltransferase (LCAT) preferentially attacks sn-1 position of 16:0-20:4 phosphatidylcholine (PC), producing more 16:0 cholesteryl ester (CE) than 20:4 CE.	Phosphatidylcholines	121-123	lecithin-cholesterol acyltransferase	Homo sapiens	44-48
7947733-0	1994	Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase.	Phosphatidylcholines	27-46	solute carrier family 38 member 5	Homo sapiens	8-12
7947733-0	1994	Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase.	Phosphatidylcholines	27-46	lecithin-cholesterol acyltransferase	Homo sapiens	92-128
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	118-137	lecithin-cholesterol acyltransferase	Homo sapiens	22-58
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	118-137	lecithin-cholesterol acyltransferase	Homo sapiens	60-64
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	118-137	solute carrier family 38 member 5	Homo sapiens	101-105
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	139-141	lecithin-cholesterol acyltransferase	Homo sapiens	22-58
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	139-141	lecithin-cholesterol acyltransferase	Homo sapiens	60-64
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	139-141	solute carrier family 38 member 3	Homo sapiens	232-236
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	139-141	solute carrier family 38 member 5	Homo sapiens	101-105
7947733-1	1994	Although human plasma lecithin-cholesterol acyltransferase (LCAT) is believed to be specific for the sn-2 position of phosphatidylcholine (PC), our recent studies showed that it derives a significant percent of acyl groups from the sn-1 position of certain PC species.	Phosphatidylcholines	257-259	lecithin-cholesterol acyltransferase	Homo sapiens	60-64
7947733-2	1994	To understand the physicochemical basis for this altered positional specificity, we determined the effect of sn-2 acyl group of PC on the enzyme activity and utilization of 16:0 from the sn-1 position by purified human and rat LCATs.	Phosphatidylcholines	128-130	solute carrier family 38 member 5	Homo sapiens	109-113
7947733-2	1994	To understand the physicochemical basis for this altered positional specificity, we determined the effect of sn-2 acyl group of PC on the enzyme activity and utilization of 16:0 from the sn-1 position by purified human and rat LCATs.	Phosphatidylcholines	128-130	solute carrier family 38 member 3	Homo sapiens	187-191
7947733-3	1994	Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT.	Phosphatidylcholines	22-24	solute carrier family 38 member 5	Homo sapiens	44-48
7947733-3	1994	Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT.	Phosphatidylcholines	22-24	lecithin-cholesterol acyltransferase	Homo sapiens	82-86
7947733-3	1994	Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT.	Phosphatidylcholines	22-24	solute carrier family 38 member 3	Homo sapiens	110-114
7947733-3	1994	Positional isomers of PC containing 16:0 at sn-2 were better substrates for human LCAT than the corresponding sn-1-16:0 isomers, whereas the reverse was true for rat LCAT.	Phosphatidylcholines	22-24	lecithin cholesterol acyltransferase	Rattus norvegicus	166-170
7947733-9	1994	These results show that the positional specificity of LCAT is influenced by the structure of PC, especially the chain length of the sn-2 acyl group.	Phosphatidylcholines	93-95	lecithin-cholesterol acyltransferase	Homo sapiens	54-58
7947733-9	1994	These results show that the positional specificity of LCAT is influenced by the structure of PC, especially the chain length of the sn-2 acyl group.	Phosphatidylcholines	93-95	solute carrier family 38 member 5	Homo sapiens	132-136
7957936-0	1994	The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice.	Phosphatidylcholines	56-75	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	10-14
7957936-2	1994	Mice lacking this protein are unable to secrete phosphatidylcholine (PC) into bile, suggesting that this P-gp is a PC translocator.	Phosphatidylcholines	69-71	phosphoglycolate phosphatase	Mus musculus	105-109
7961735-5	1994	The CPT1 gene product was responsible for 95% of phosphatidylcholine (PC) synthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	49-68	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	4-8
7961735-5	1994	The CPT1 gene product was responsible for 95% of phosphatidylcholine (PC) synthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	70-72	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	4-8
7971987-3	1994	When reincorporated into artificial bilayers formed from phosphatidylcholine, it was able to transport a spin-labeled phosphatidylserine analogue from the inner to the outer membrane leaflet provided Mg2+ ATP was present in the incubation mixture.	Phosphatidylcholines	57-76	mucin 7, secreted	Homo sapiens	200-203
7961735-6	1994	The EPT1 gene product accounted for only 5% of PC synthesis in vivo.	Phosphatidylcholines	47-49	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	4-8
7961735-7	1994	Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo.	Phosphatidylcholines	230-232	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	9-13
7961735-7	1994	Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo.	Phosphatidylcholines	230-232	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	186-190
7961735-7	1994	Chimeric CPT1/EPT1 enzymes with diacylglycerol and CDP-aminoalcohol specificities both similar and distinct from the parental enzymes were used to determine the specific segments of the CPT1/EPT1 gene products required to restore PC synthesis to cpt- cells in vivo.	Phosphatidylcholines	230-232	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	191-195
7961735-12	1994	The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis.	Phosphatidylcholines	49-51	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	28-32
7961735-12	1994	The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis.	Phosphatidylcholines	127-129	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	28-32
7961735-12	1994	The data also implicate the CPT1 gene product in PC biosynthesis from an endogenous source of choline derived from turnover of PC via the phosphatidylserine-dependent route for PC synthesis.	Phosphatidylcholines	127-129	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	28-32
7961445-5	1994	Such an ethanolamine-dependent reduction in bulk membrane PC content was observed for both choline kinase (cki) and choline phosphotransferase (cpt1) mutants, but it was not observed for mutants defective in cholinephosphate cytidylyltransferase, the enzyme that catalyzes the penultimate reaction of the CDP-choline pathway for PC biosynthesis.	Phosphatidylcholines	58-60	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	144-148
7895399-4	1994	PLA2 activity was measured in lysates of the various cell fractions by the hydrolysis of radiolabeled lysocholine from phosphatidylcholine, L-Dipalmitoyl using thin layer chromatography.	Phosphatidylcholines	119-138	phospholipase A2 group IB	Homo sapiens	0-4
7977654-4	1994	These mice are unable to secrete phospholipids into bile, showing an essential role for the mdr2 P-glycoprotein in the transport of phosphatidylcholine across the canalicular membrane.	Phosphatidylcholines	132-151	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	92-96
7977654-4	1994	These mice are unable to secrete phospholipids into bile, showing an essential role for the mdr2 P-glycoprotein in the transport of phosphatidylcholine across the canalicular membrane.	Phosphatidylcholines	132-151	ATP binding cassette subfamily B member 1	Homo sapiens	97-111
7964477-4	1994	CD69 cross-linking resulted also in phospholipase A2 activation, as detected by in vivo arachidonic acid release measurement from intact cells and by direct in vitro measurement of enzymatic activity using radiolabeled phosphatidylcholine vesicles.	Phosphatidylcholines	219-238	CD69 molecule	Homo sapiens	0-4
7964477-4	1994	CD69 cross-linking resulted also in phospholipase A2 activation, as detected by in vivo arachidonic acid release measurement from intact cells and by direct in vitro measurement of enzymatic activity using radiolabeled phosphatidylcholine vesicles.	Phosphatidylcholines	219-238	phospholipase A2 group IB	Homo sapiens	36-52
7853148-5	1994	Phosphatidylserine is synthesized by the two kinds of base-exchange enzymes, namely serine-exchange enzyme I and II, through the chain reactions in participation of phosphatidylserine decarboxylase; phosphatidylcholine--&gt;phosphatidylserine--&gt;phosphatidylethanolamine--&gt; phosphatidylserine.	Phosphatidylcholines	199-218	phosphatidylserine synthase 1	Homo sapiens	84-115
7859925-1	1994	We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	49-68	endothelin 1	Mus musculus	26-38
7859925-1	1994	We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	49-68	endothelin 1	Mus musculus	40-44
7853148-6	1994	The substrates of serine-exchange enzyme I are phosphatidylcholine, and either choline, serine, or ethanolamine, while those of serine-exchange enzyme II are phosphatidylethanolamine, and serine or ethanolamine but not choline.	Phosphatidylcholines	47-66	phosphatidylserine synthase 1	Homo sapiens	18-42
7524684-10	1994	Translocation of a PKC isoform could be accounted for by whether the increased DAG originated from PIP2 (accompanied by translocation) or from phosphatidylcholine (no accompanying translocation).	Phosphatidylcholines	143-162	protein kinase C, alpha	Rattus norvegicus	19-22
7929289-1	1994	Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa.	Phosphatidylcholines	87-89	coagulation factor X	Homo sapiens	0-14
7929289-1	1994	Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa.	Phosphatidylcholines	87-89	coagulation factor X	Homo sapiens	184-222
7944397-4	1994	Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC.	Phosphatidylcholines	36-55	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
7944397-4	1994	Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC.	Phosphatidylcholines	57-63	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
7931078-16	1994	Furthermore, IL-4R is not coupled to sphingomyelinase (SMase) since IL-4, unlike exogenous SMase, did not generate ceramide but induced the hydrolysis of PC to pchol that was comparable to exogenous PLC.	Phosphatidylcholines	154-156	interleukin 4 receptor	Homo sapiens	13-18
7819508-1	1994	Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner.	Phosphatidylcholines	117-136	coagulation factor II, thrombin	Bos taurus	36-47
7819508-1	1994	Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner.	Phosphatidylcholines	138-140	coagulation factor II, thrombin	Bos taurus	36-47
7931078-16	1994	Furthermore, IL-4R is not coupled to sphingomyelinase (SMase) since IL-4, unlike exogenous SMase, did not generate ceramide but induced the hydrolysis of PC to pchol that was comparable to exogenous PLC.	Phosphatidylcholines	154-156	interleukin 4	Homo sapiens	13-17
7931078-6	1994	Experiments were performed using [14C-methyl]choline-labeled U937 cells and monocytes to determine whether IL-4R activated phospholipase C (PLC), PLD, or PLA2 to use membrane phosphatidylcholine (PC) to form DAG.	Phosphatidylcholines	175-194	interleukin 4 receptor	Homo sapiens	107-112
7931078-8	1994	The finding that the peak reduction of PC was equivalent to peak production of pchol suggested that IL-4R signaling involved the activation of a PC-specific PLC.	Phosphatidylcholines	39-41	interleukin 4 receptor	Homo sapiens	100-105
7931078-17	1994	In summary, IL-4R signaling in monocytes and U937 cells involves PLC and not PLD, PLA2, or SMase, and it uses PC and not PIP2 to form DAG.	Phosphatidylcholines	110-112	interleukin 4 receptor	Homo sapiens	12-17
7760585-1	1994	CDP-choline participates in brain phospholipid metabolism and acts as an endogenous intermediate in a biosynthetic pathway incorporating free choline into phosphatidylcholine and choline plasmalogens in several tissues, including the central nervous system (CNS).	Phosphatidylcholines	155-174	cut like homeobox 1	Homo sapiens	0-3
7945188-1	1994	The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells.	Phosphatidylcholines	138-157	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-19
7994181-4	1994	Moreover, assays of soybean AAPT1-encoded enzyme activity in yeast microsomal membranes revealed that the addition of CDP-ethanolamine to the reaction inhibited incorporation of 14C-CDP-choline into phosphatidylcholine in a manner very similar to that observed using unlabeled CDP-choline.	Phosphatidylcholines	199-218	aminoalcoholphosphotransferase	Glycine max	28-33
7945188-1	1994	The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells.	Phosphatidylcholines	138-157	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
7945188-1	1994	The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells.	Phosphatidylcholines	159-165	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-19
7945188-1	1994	The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells.	Phosphatidylcholines	159-165	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
7945188-4	1994	The PLD activators sphingosine and H2O2 were found to elicit only a slight (1.28-1.4-fold) stimulatory effect on PtdCho hydrolysis in both the MCF-7/WT and MCF-7/MDR cell types, and had only a small effect on PtdEtn hydrolysis in the MCF-7/WT cells as well.	Phosphatidylcholines	113-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
8001180-5	1994	The lipid mixtures sufficient to yield full photochemical function of rhodopsin include a native-like head group composition, viz, comprising phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS), in combination with polyunsaturated docosahexaenoic acid (DHA; 22:6 omega 3) chains.	Phosphatidylcholines	142-161	rhodopsin	Homo sapiens	70-79
8068732-7	1994	Interestingly, PLA2 able to induce platelet activation efficiently hydrolyse phosphatidylcholine, while those inactive on platelets did not.	Phosphatidylcholines	77-96	phospholipase A2 group IIA	Homo sapiens	15-19
8080278-2	1994	When the PC-reconstituted membranes were incubated with ascorbic acid/Fe2+, the ALP activity decreased with increases in the thiobarbituric acid-reactive substances and conjugated diene values in a time-dependent manner.	Phosphatidylcholines	9-11	alkaline phosphatase, placental	Homo sapiens	80-83
8075084-3	1994	Vaccinia profilin binds to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-monophosphate in micelles and large unilamellar vesicles, but not to phosphatidylserine or phosphatidylcholine.	Phosphatidylcholines	183-202	profilin	Saccharomyces cerevisiae S288C	9-17
7935319-1	1994	Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist.	Phosphatidylcholines	140-159	cholinergic receptor muscarinic 3	Homo sapiens	18-40
7935319-1	1994	Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist.	Phosphatidylcholines	140-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-109
7935319-1	1994	Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist.	Phosphatidylcholines	140-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	111-114
8068732-9	1994	Moreover, the ability of PLA2 to induce platelet activation is not related to its structural group (I, II, III) but rather to its origin (venom vs. mammalian) and capacity to hydrolyse phosphatidylcholine, the major phospholipid of the outer leaflet of the plasma membrane.	Phosphatidylcholines	185-204	phospholipase A2 group IIA	Homo sapiens	25-29
8068618-1	1994	We determined a detailed conformation of the honeybee venom peptide melittin when bound to phosphatidylcholine vesicles using proton NMR.	Phosphatidylcholines	91-110	melittin	Apis mellifera	68-76
8063752-5	1994	Like SCP2, recombinant SCPx also stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol from small unilamellar vesicles to acceptor membranes in vitro.	Phosphatidylcholines	123-142	sterol carrier protein 2	Homo sapiens	23-27
7545943-3	1994	In vitro, MTP catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces.	Phosphatidylcholines	78-97	microsomal triglyceride transfer protein	Homo sapiens	10-13
8080441-7	1994	All PKC activators stimulated a phospholipase A2-mediated arachidonic acid release, a phospholipase D-mediated phosphatidylcholine hydrolysis, a comparable small proliferative response and an inhibition of phospholipase C-mediated inositol trisphosphate generation.	Phosphatidylcholines	111-130	protein kinase C, alpha	Rattus norvegicus	4-7
8053894-3	1994	Vesicles of PtdCho, PtdIns/PtdCho, PtdSer/PtdCho and PtdEtn/PtdCho increased thrombin-thrombomodulin-catalysed protein C activation by 1.2-, 1.9-, 4.3- and 8.4-fold respectively compared with that in the absence of phospholipid.	Phosphatidylcholines	12-18	coagulation factor II, thrombin	Homo sapiens	77-85
7987266-0	1994	Induction of stearoyl-CoA desaturase 2 gene expression correlates with fatty acid changes in phosphatidylcholine.	Phosphatidylcholines	93-112	stearoyl-Coenzyme A desaturase 2	Mus musculus	13-38
8051052-10	1994	A plb1 delta mutant released wild-type levels of the soluble phosphatidylinositol metabolite glycerophosphoinositol into the growth medium but released greatly reduced levels of the corresponding phosphatidylcholine and phosphatidylethanolamine metabolites.	Phosphatidylcholines	196-215	lysophospholipase	Saccharomyces cerevisiae S288C	2-6
8051052-11	1994	These results indicate that PLB1 is principally responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol.	Phosphatidylcholines	110-129	lysophospholipase	Saccharomyces cerevisiae S288C	28-32
8049194-1	1994	In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, &lt; 30 seconds).	Phosphatidylcholines	222-241	HDL3	Homo sapiens	81-85
8049194-1	1994	In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, &lt; 30 seconds).	Phosphatidylcholines	222-241	HDL3	Homo sapiens	127-131
8049194-1	1994	In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, &lt; 30 seconds).	Phosphatidylcholines	222-241	HDL3	Homo sapiens	127-131
8049194-1	1994	In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose dependent (IC50, 150 +/- 20 micrograms/mL, n = 6) and time dependent (t1/2, &lt; 30 seconds).	Phosphatidylcholines	222-241	HDL3	Homo sapiens	127-131
8053894-3	1994	Vesicles of PtdCho, PtdIns/PtdCho, PtdSer/PtdCho and PtdEtn/PtdCho increased thrombin-thrombomodulin-catalysed protein C activation by 1.2-, 1.9-, 4.3- and 8.4-fold respectively compared with that in the absence of phospholipid.	Phosphatidylcholines	12-18	thrombomodulin	Homo sapiens	86-100
8048539-2	1994	This increase was accompanied by an increase in CTP:phosphocholine cytidylyltransferase activity, which catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells.	Phosphatidylcholines	148-167	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	48-87
7857772-0	1994	Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes.	Phosphatidylcholines	19-38	insulin	Homo sapiens	0-7
7890144-4	1994	Both membrane-active peptides, cardiotoxin and thionin, inhibited the PLA2 activity on phosphatidylcholine liposomes.	Phosphatidylcholines	87-106	phospholipase A2 group IB	Homo sapiens	70-74
8042784-5	1994	RESULTS: Both halothane (50% effective concentration = 2.2 vol%) and propofol (50% effective concentration = 240 microM) markedly stimulated histone H1 phosphorylation by PKC in the presence of a lipid vesicle preparation consisting of phosphatidylcholine, phosphatidylserine, and diacylglycerol.	Phosphatidylcholines	236-255	protein kinase C, gamma	Rattus norvegicus	171-174
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Phosphatidylcholines	120-139	tumor necrosis factor	Homo sapiens	0-27
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Phosphatidylcholines	120-139	tumor necrosis factor	Homo sapiens	29-38
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Phosphatidylcholines	120-139	interleukin 1 alpha	Homo sapiens	44-57
8025110-2	1994	Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions.	Phosphatidylcholines	52-71	microtubule associated protein 2	Homo sapiens	31-35
8025110-2	1994	Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions.	Phosphatidylcholines	52-71	microtubule associated protein 2	Homo sapiens	43-48
8025110-2	1994	Examinations of the binding of MAP2 and/or MAP2C to phosphatidylcholine vesicles doped with phosphatidylinositol or to phosphatidylserine vesicles and of thrombin-digested MAP2C to phosphatidylinositol vesicles demonstrates that the observed high affinity of the MAP2: phosphatidylinositol binding is due to the contributions of two separate interactions.	Phosphatidylcholines	52-71	microtubule associated protein 2	Homo sapiens	43-47
8037660-11	1994	We conclude that cholinephosphotransferase catalyses the formation of both phosphatidylcholine and plasmenylcholine in the guinea-pig tissues and the rate of plasmenylcholine biosynthesis is dependent on the availability of 1-alk-1"-enyl-2-acylglycerol.	Phosphatidylcholines	75-94	cholinephosphotransferase 1	Cavia porcellus	17-42
7918869-4	1994	That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate.	Phosphatidylcholines	162-181	phospholipase A2 group IB	Rattus norvegicus	5-9
7918869-4	1994	That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate.	Phosphatidylcholines	162-181	phospholipase A2 group IB	Rattus norvegicus	111-115
7918869-4	1994	That PLA2 was the main enzyme responsible for cleavage of AA from membrane phospholipids was directly shown by PLA2 activity assay using vesicles of radiolabeled phosphatidylcholine (PC) as substrate.	Phosphatidylcholines	183-185	phospholipase A2 group IB	Rattus norvegicus	5-9
8026481-3	1994	Asymmetrical distributions and translocation kinetics were very different for spin-labeled phosphatidylserine and spin-labeled phosphatidylcholine in fresh platelet plasma membranes.	Phosphatidylcholines	127-146	spindlin 1	Homo sapiens	114-118
8063019-4	1994	PLA2 activity in sonicates from ram spermatozoa was enhanced when 1-stearoyl-2-arachidonoyl-sn-glycerol, the diacylglycerol usually generated by polyphosphoinositide breakdown, was added to a radioactive phosphatidylcholine substrate; the effect was time- and Ca(2+)-dependent.	Phosphatidylcholines	204-223	phospholipase A2 group IB	Homo sapiens	0-4
7912658-0	1994	Phosphatidylcholine translocase: a physiological role for the mdr2 gene.	Phosphatidylcholines	0-19	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	62-66
8040266-0	1994	Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins.	Phosphatidylcholines	50-69	tumor necrosis factor	Homo sapiens	0-27
8011678-1	1994	The simultaneous incorporation of a saturated fatty acid in the sn-1 position and an unsaturated fatty acid in the sn-2 position in phosphatidylcholine (PC) and ethanolamine (PE) was studied in isolated liver cells.	Phosphatidylcholines	132-151	solute carrier family 38 member 5	Homo sapiens	115-119
8011678-1	1994	The simultaneous incorporation of a saturated fatty acid in the sn-1 position and an unsaturated fatty acid in the sn-2 position in phosphatidylcholine (PC) and ethanolamine (PE) was studied in isolated liver cells.	Phosphatidylcholines	153-155	solute carrier family 38 member 5	Homo sapiens	115-119
8026481-5	1994	However, spin-labeled phosphatidylcholine was mainly retained on the external leaflet.	Phosphatidylcholines	22-41	spindlin 1	Homo sapiens	9-13
8204634-5	1994	The apparent enthalpy of association (delta H(assoc)) of both factor X and prothrombin with phosphatidylserine (PS)/phosphatidylcholine (PC) large unilamellar vesicles (LUVs, 120 nm diameter) was shown to be near 0 kcal/mol.	Phosphatidylcholines	116-135	coagulation factor II, thrombin	Homo sapiens	75-86
8003498-3	1994	Upon Ca2+ crenation of cells, surface exposure of phosphatidylserine and phosphatidylethanolamine was observed simultaneously with inward diffusion of phosphatidylcholine.	Phosphatidylcholines	151-170	carbonic anhydrase 2	Homo sapiens	5-8
8207217-3	1994	These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD.	Phosphatidylcholines	76-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-46
8207217-3	1994	These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD.	Phosphatidylcholines	76-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	48-51
8207217-3	1994	These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD.	Phosphatidylcholines	76-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
8199206-4	1994	Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation.	Phosphatidylcholines	20-39	PCNA clamp associated factor	Homo sapiens	76-79
8199202-3	1994	The administration of the drug enhanced the formation in vivo of PtdCho from [3H]glycerol, which seemed to be due to the increase in activity of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	65-71	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	145-184
8199206-4	1994	Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation.	Phosphatidylcholines	20-39	PCNA clamp associated factor	Homo sapiens	215-218
8199206-4	1994	Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation.	Phosphatidylcholines	41-43	PCNA clamp associated factor	Homo sapiens	76-79
8199206-4	1994	Peroxidation of the phosphatidylcholine (PC) content of native LDL produces PAF-like aggregating activity much lower than that produced when intact LDL is oxidized and is not inhibited by BN 52021 as effectively as PAF produced by LDL peroxidation.	Phosphatidylcholines	41-43	PCNA clamp associated factor	Homo sapiens	215-218
7943660-1	1994	UNLABELLED: Phosphatidylethanolamine N-methyltransferase participates in the synthesis of membrane phosphatidylcholine.	Phosphatidylcholines	99-118	phosphatidylethanolamine N-methyltransferase	Homo sapiens	12-56
8196611-1	1994	v-Src-induced increases in diglyceride are derived from phosphatidylcholine via a type D phospholipase (PLD) and a phosphatidic acid phosphatase.	Phosphatidylcholines	56-75	Rous sarcoma oncogene	Mus musculus	2-5
7943660-4	1994	Phosphatidylethanolamine N-methyltransferase activity was measured in sequential percutaneous needle liver biopsies by the conversion of phosphatidylethanolamine to phosphatidylcholine, using radioactive S-adenosylmethionine as a methyl donor.	Phosphatidylcholines	165-184	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-44
7943660-12	1994	Phosphatidylcholine administration ameliorates the ethanol-induced decrease in phosphatidylethanolamine N-methyltransferase activity and corrects phospholipid and phosphatidylcholine depletions, thereby possibly contributing to the protection against alcoholic liver injury.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Homo sapiens	79-123
8200132-12	1994	Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues.	Phosphatidylcholines	74-93	endothelin receptor type A	Mus musculus	65-68
8090060-0	1994	Effects of soybean lipoxygenase-1 on phosphatidylcholines containing furan fatty acids.	Phosphatidylcholines	37-57	seed linoleate 13S-lipoxygenase-1	Glycine max	19-33
8090060-6	1994	F-acids located at the sn-2 position of a synthetic phosphatidylcholine (PC), containing linoleic acid in the sn-1 position, are co-oxidized to a greater extent by incubation with soybean lipoxygenase-1 than are F-acids bound to PC with myristic acid in the sn-1 position when subjected to the enzyme in the presence of a great excess of linoleic acid.	Phosphatidylcholines	52-71	seed linoleate 13S-lipoxygenase-1	Glycine max	188-202
8090060-6	1994	F-acids located at the sn-2 position of a synthetic phosphatidylcholine (PC), containing linoleic acid in the sn-1 position, are co-oxidized to a greater extent by incubation with soybean lipoxygenase-1 than are F-acids bound to PC with myristic acid in the sn-1 position when subjected to the enzyme in the presence of a great excess of linoleic acid.	Phosphatidylcholines	73-75	seed linoleate 13S-lipoxygenase-1	Glycine max	188-202
8200132-12	1994	Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues.	Phosphatidylcholines	95-97	endothelin receptor type A	Mus musculus	65-68
8196611-2	1994	v-Src-induced PLD activity, as measured by PLD-catalyzed transphosphatidylation of phosphatidylcholine to phosphatidylethanol, is inhibited by GDP beta S, which inhibits G-protein-mediated intracellular signals.	Phosphatidylcholines	83-102	Rous sarcoma oncogene	Mus musculus	2-5
8196611-4	1994	The effect of GTP gamma S on PLD activity in v-Src-transformed cells was observed only when cells were prelabeled with [3H]myristate, which is incorporated exclusively into phosphatidylcholine, the substrate for the v-Src-induced PLD.	Phosphatidylcholines	173-192	Rous sarcoma oncogene	Mus musculus	47-50
8196611-4	1994	The effect of GTP gamma S on PLD activity in v-Src-transformed cells was observed only when cells were prelabeled with [3H]myristate, which is incorporated exclusively into phosphatidylcholine, the substrate for the v-Src-induced PLD.	Phosphatidylcholines	173-192	Rous sarcoma oncogene	Mus musculus	218-221
8011929-11	1994	An appropriate combination (75:25) of phosphatidylcholine from rat liver with phosphatidylethanolamines from cold adapted species showed a drastic fluidization at the C-2 segment, in comparison with their phosphatidylcholines.	Phosphatidylcholines	38-57	complement C2	Rattus norvegicus	167-170
8182058-1	1994	Sonicated unilamellar phosphatidylcholine vesicles induce hemoglobin oxidation in erythrocytes and resealed membrane fragments (buds) at pH 5.5.	Phosphatidylcholines	22-41	HGB	Sus scrofa	58-68
8039770-7	1994	In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed.	Phosphatidylcholines	83-102	heparan sulfate proteoglycan 2	Homo sapiens	112-115
8039770-7	1994	In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed.	Phosphatidylcholines	83-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	120-123
7940575-0	1994	Exposure of phosphatidylcholine and phosphatidylinositol in plasma membranes from rat brain synaptosomes treated with phospholipase A2 toxins (beta-bungarotoxin, notexin) and enzymes (Naja nigricollis, Naja naja atra).	Phosphatidylcholines	12-31	phospholipase A2 group IB	Rattus norvegicus	118-134
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	52-71	kininogen 1	Homo sapiens	0-2
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	52-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	52-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	73-75	kininogen 1	Homo sapiens	0-2
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	73-75	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
8176221-6	1994	BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells.	Phosphatidylcholines	73-75	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
8172918-1	1994	Incubation of radiolabeled vasoactive intestinal polypeptide (VIP) with preformed lipid vesicles composed of phosphatidylcholine, phosphatidylglycerol and cholesterol resulted in reversible and saturable association of the peptide with the lipid bilayer.	Phosphatidylcholines	109-128	vasoactive intestinal peptide	Homo sapiens	27-60
8172918-1	1994	Incubation of radiolabeled vasoactive intestinal polypeptide (VIP) with preformed lipid vesicles composed of phosphatidylcholine, phosphatidylglycerol and cholesterol resulted in reversible and saturable association of the peptide with the lipid bilayer.	Phosphatidylcholines	109-128	vasoactive intestinal peptide	Homo sapiens	62-65
8051988-5	1994	CDP-choline (cytidine-5-diphosphate-choline) participates in the phospholipid metabolism pathway incorporating free choline into phosphatidyl-choline and choline plasmalogens in several tissues, including the central nervous system.	Phosphatidylcholines	129-149	cut like homeobox 1	Homo sapiens	0-3
7513707-4	1994	An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF.	Phosphatidylcholines	187-206	TNF receptor superfamily member 8	Homo sapiens	67-75
7513707-4	1994	An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF.	Phosphatidylcholines	187-206	colony stimulating factor 1	Homo sapiens	133-138
8071599-7	1994	Phosphatidylcholine increased apoB synthesis and secretion without affecting the synthesis or secretion of apoA-I.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	30-34
8071599-8	1994	Phosphatidylcholine also reversed the effect of A23187 on apoB secretion.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	58-62
8071599-9	1994	When phosphatidylcholine was added to the basolateral medium, apoB secretion was not altered.	Phosphatidylcholines	5-24	apolipoprotein B	Homo sapiens	62-66
8071599-17	1994	Phosphatidylcholine, independent of triacylglycerol flux and independent of its hydrolysis, increases the secretion of apoB by increasing apoB synthesis.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	119-123
8071599-17	1994	Phosphatidylcholine, independent of triacylglycerol flux and independent of its hydrolysis, increases the secretion of apoB by increasing apoB synthesis.	Phosphatidylcholines	0-19	apolipoprotein B	Homo sapiens	138-142
8071599-18	1994	Luminal phosphatidylcholine may play a role in apoB secretion in the intestine.	Phosphatidylcholines	8-27	apolipoprotein B	Homo sapiens	47-51
8161559-2	1994	Fluorescence quenching studies show that cholesterol-containing phosphatidylcholines can bind at the lipid-protein interface of the Ca(2+)-ATPase from skeletal muscle sarcoplasmic reticulum, with an affinity half that of dioleoylphosphatidylcholine.	Phosphatidylcholines	64-84	dynein axonemal heavy chain 8	Homo sapiens	139-145
8161559-3	1994	The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine.	Phosphatidylcholines	90-109	dynein axonemal heavy chain 8	Homo sapiens	4-10
8161559-3	1994	The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine.	Phosphatidylcholines	90-109	dynein axonemal heavy chain 8	Homo sapiens	37-43
8161559-3	1994	The ATPase activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing an oleoyl fatty acyl chain, (C18:1, CHS)PC, is less than that measured for the ATPase reconstituted with dioleoylphosphatidylcholine.	Phosphatidylcholines	90-109	dynein axonemal heavy chain 8	Homo sapiens	37-43
8161559-4	1994	The activity measured for the ATPase reconstituted with the cholesterol-containing phosphatidylcholine containing a myristoleoyl fatty acyl chain, (C14:1, CHS)PC, is less than that measured in (C18:1,CHS)PC and is comparable to that measured in dimyristoleoylphosphatidylcholine (di(C14: 1)PC.	Phosphatidylcholines	83-102	dynein axonemal heavy chain 8	Homo sapiens	30-36
8144637-10	1994	In addition, the rate of 2AP transfer from A- and H-FABP was enhanced by unsaturation of the phosphatidylcholine acyl chains and was slowed by the presence of cholesterol or sphingomyelin in the acceptor membranes.	Phosphatidylcholines	93-112	fatty acid binding protein 3	Homo sapiens	50-56
8185671-2	1994	In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990).	Phosphatidylcholines	119-138	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	69-84
8185671-2	1994	In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990).	Phosphatidylcholines	119-138	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-89
8185671-2	1994	In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990).	Phosphatidylcholines	140-146	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	69-84
8185671-2	1994	In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990).	Phosphatidylcholines	140-146	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-89
7512965-13	1994	(iii) Adhesion of alpha 5 beta 1-containing liposomes (phosphatidylcholine:cholesterol liposomes incorporating purified alpha 5 beta 1) to FN-coated plates was abolished by treatment of liposomes with endo-F/PNGase-F. Liposomes incorporating alpha 5 beta 1 pretreated with endo-F/PNGase-F also did not bind to FN.	Phosphatidylcholines	55-74	fibronectin 1	Homo sapiens	139-141
8053546-9	1994	These results show that a fluorescent assay can be used to rapidly assess the activity of PLD and other phosphatidylcholine-utilizing phospholipases in cell and tissue extracts.	Phosphatidylcholines	104-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	90-93
8166635-3	1994	ACBP was able to extract hexadecanoyl-CoA from phosphatidylcholine membranes immobilized on a nitrocellulose membrane.	Phosphatidylcholines	47-66	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-4
8053546-2	1994	A rapid assay for agonist-activated PLD activity in cell extracts was developed, utilizing a fluorescent derivative of phosphatidylcholine as substrate.	Phosphatidylcholines	119-138	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
8043301-4	1994	In contrast, the rate of incorporation of labeled choline into PC, presumably via CDP-choline, was virtually identical in cells that had been preincubated in the presence or absence of 1 mM choline.	Phosphatidylcholines	63-65	cut like homeobox 1	Homo sapiens	82-85
8166295-3	1994	ET-1 stimulated the secretion of PC in a time- and dose-dependent manner.	Phosphatidylcholines	33-35	endothelin 1	Rattus norvegicus	0-4
8132522-6	1994	The difference increased to 740-fold using TF relipidated in vesicles composed of 80% phosphatidylcholine and 20% phosphatidylserine (TF/PCPS).	Phosphatidylcholines	86-105	coagulation factor III, tissue factor	Homo sapiens	43-45
8141780-0	1994	Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway.	Phosphatidylcholines	130-149	epidermal growth factor	Homo sapiens	0-23
8118639-6	1994	The synthesis of PC by pneumocytes in both the donor (1.13 +/- 0.19 versus 3.44 +/- 0.19 pmol/micrograms protein, p &lt; 0.01) and cancer (0.99 +/- 0.11 versus 2.15 +/- 0.15 pmol/micrograms protein, p &lt; 0.01) groups was decreased by TNF-alpha (100 ng/ml).	Phosphatidylcholines	17-19	tumor necrosis factor	Homo sapiens	236-245
8133286-0	1994	Monogalactosyl diglyceride, a marker for myelination, activates oligodendroglial protein kinase C. Protein kinase C (PKC) is activated by 1,2-sn-diacylglycerol (DAG), the source of which can either be phosphatidylinositol bisphosphate or phosphatidylcholine.	Phosphatidylcholines	238-257	protein kinase C alpha	Homo sapiens	117-120
8132633-8	1994	Thin layer chromatography of the HDL3 phospholipid fraction from five normolipidemic subjects revealed that it consists of approximately 84% phosphatidylcholine, 12% sphingomyelin, and 4% phosphatidylinositol (PI) by weight.	Phosphatidylcholines	141-160	HDL3	Homo sapiens	33-37
8144898-11	1994	CRP binding to complement-treated liposomes required phosphatidylcholine in addition to the MAC indicating that membrane phospholipids rather than the MAC proteins provide the binding sites for CRP.	Phosphatidylcholines	53-72	C-reactive protein	Homo sapiens	0-3
8123005-3	1994	Since GH stimulates the formation of diacylglycerol from phosphatidylcholine independently of Ca2+ mobilization, the role of Ca2+ was studied in regard to LPL gene expression stimulated by GH.	Phosphatidylcholines	57-76	growth hormone	Mus musculus	6-8
8203755-1	1994	A method for the determination of the relative amounts of the diacyl, alkylacyl, and alk-1-enylacyl subclasses of choline glycerophospholipids by benzoolysis is described.	Phosphatidylcholines	114-142	secretory leukocyte peptidase inhibitor	Homo sapiens	85-90
8177371-4	1994	With choline phosphoglyceride as a substrate, phospholipase A2 activity was predominantly Ca(2+)-dependent, although a small, but measurable Ca(2+)-independent component was present.	Phosphatidylcholines	5-29	phospholipase A2, group IB, pancreas	Mus musculus	46-62
8177371-6	1994	These findings indicate that activity of a phospholipase A2, which utilizes choline phosphoglyceride as a substrate, is affected by the aging process.	Phosphatidylcholines	76-100	phospholipase A2, group IB, pancreas	Mus musculus	43-59
8119913-0	1994	Overexpression of rat liver CTP:phosphocholine cytidylyltransferase accelerates phosphatidylcholine synthesis and degradation.	Phosphatidylcholines	80-99	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	28-67
8119913-4	1994	The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction.	Phosphatidylcholines	88-90	cut-like homeobox 1	Rattus norvegicus	4-7
8119913-4	1994	The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction.	Phosphatidylcholines	88-90	cut-like homeobox 1	Rattus norvegicus	73-76
8135530-1	1994	The reaction of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and Ebselen with phospholipid and cholesterylester hydroperoxides associated with HDLox and LDLox was investigated using specific HPLC assays for the hydroperoxides of phosphatidylcholine (PCOOH) and cholesteryllinolate (Ch18:2-OOH) and for cholesteryllinolate hydroxides (Ch18:2-OH).	Phosphatidylcholines	242-261	glutathione peroxidase 4	Homo sapiens	67-72
7998342-1	1994	Peroxidation of lipids induced by methemoglobin in liposomes forms of mixtures of phosphatidylcholine and cardiolipin has been studied.	Phosphatidylcholines	82-101	hemoglobin subunit gamma 2	Homo sapiens	34-47
8123678-5	1994	Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids.	Phosphatidylcholines	69-88	lipoprotein(a)	Homo sapiens	0-4
7508929-3	1994	With unilamellar vesicles (including 20 mol% brain phosphatidylserine), increased phosphatidylcholine unsaturation potentiated basal and phorbol ester stimulated PKC activity.	Phosphatidylcholines	82-101	protein kinase C, gamma	Rattus norvegicus	162-165
7508929-6	1994	When the PKC activities with vesicles of varying phosphatidylcholine unsaturation, with and without phosphatidylethanolamine, were plotted as a function of the fluorescence intensity of C6-NBD-PC-labeled vesicles, a biphasic profile was obtained, which had an optimum value of intensity, relating to head group spacing, that corresponded to a maximal enzyme activity.	Phosphatidylcholines	49-68	protein kinase C, gamma	Rattus norvegicus	9-12
7508929-9	1994	Therefore, increasing the level of phosphatidylcholine unsaturation, phosphatidylethanolamine, or cholesterol either potentiates or attenuates PKC activity, dependent on whether the initial condition is above or below its optimum.	Phosphatidylcholines	35-54	protein kinase C, gamma	Rattus norvegicus	143-146
8119280-2	1994	In 1990, we reported that neutral phosphatidylcholine membranes also stimulated prothrombin activation [Gerads, I., Govers-Riemslag, J.W.P., Tans, G., Zwaal, R. F. A.	Phosphatidylcholines	34-53	coagulation factor II, thrombin	Homo sapiens	80-91
8119280-5	1994	In the present study, we have performed a detailed analysis of the prothrombin-converting activity of phosphatidylcholine membranes.	Phosphatidylcholines	102-121	coagulation factor II, thrombin	Homo sapiens	67-78
8119280-6	1994	Stimulation of prothrombin activation by phosphatidylcholine vesicles was particularly observed (a) with phosphatidylcholine molecules that contained unsaturated hydrocarbon side chains, (b) in the presence of factor Va, (c) at low ionic strength and (d) when Ca2+ were present in the reaction medium.	Phosphatidylcholines	41-60	coagulation factor II, thrombin	Homo sapiens	15-26
8119280-6	1994	Stimulation of prothrombin activation by phosphatidylcholine vesicles was particularly observed (a) with phosphatidylcholine molecules that contained unsaturated hydrocarbon side chains, (b) in the presence of factor Va, (c) at low ionic strength and (d) when Ca2+ were present in the reaction medium.	Phosphatidylcholines	105-124	coagulation factor II, thrombin	Homo sapiens	15-26
8119280-14	1994	This indicates that similar interactions may account for the assembly of prothrombinase complexes on phosphatidylcholine and an anionic lipid-containing membranes.	Phosphatidylcholines	101-120	coagulation factor X	Homo sapiens	73-87
8123678-5	1994	Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids.	Phosphatidylcholines	69-88	lipoprotein(a)	Homo sapiens	12-16
8123678-5	1994	Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids.	Phosphatidylcholines	69-88	lipoprotein(a)	Homo sapiens	12-16
8123678-5	1994	Lp A-IV and Lp A-I: A-IV: A-II contained more sphingomyelin and less phosphatidylcholine than Lp A-I and Lp A-I: A-II and were richer in (16:0 + 18:0) saturated fatty acids.	Phosphatidylcholines	69-88	lipoprotein(a)	Homo sapiens	12-16
8123681-1	1994	CTP:phosphocholine cytidylyltransferase catalyses a rate regulatory step in the de novo synthesis of surfactant phosphatidylcholine in alveolar type II cells.	Phosphatidylcholines	112-131	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
8307196-2	1994	Purified cytochrome b559 relipidated with either a mixture of phosphatidylcholine and phosphatidic acid or with phosphatidylcholine only exhibits high and low superoxide (O2-) producing ability, respectively, in the absence of cytosolic activators [Koshkin, V. and Pick, E. (1993) FEBS Lett.	Phosphatidylcholines	62-81	mitochondrially encoded cytochrome b	Homo sapiens	9-21
8106403-6	1994	This substantial loss of activity was reconciled with the apparent retention of the integrity of the Ca(2+)-dependent conformation of this mutant by the finding that this Ca(2+)-dependent conformation of [Leu5--&gt;Gln]r-PC interacted poorly with mixed (60:40, w/w) phosphatidylcholine/phosphatidylserine (PL) vesicles.	Phosphatidylcholines	266-285	tripartite motif containing 13	Homo sapiens	205-209
8307196-2	1994	Purified cytochrome b559 relipidated with either a mixture of phosphatidylcholine and phosphatidic acid or with phosphatidylcholine only exhibits high and low superoxide (O2-) producing ability, respectively, in the absence of cytosolic activators [Koshkin, V. and Pick, E. (1993) FEBS Lett.	Phosphatidylcholines	112-131	mitochondrially encoded cytochrome b	Homo sapiens	9-21
8307196-6	1994	High affinity binding of FAD to cytochrome b559 relipidated with phosphatidylcholine combined with phosphatidic acid is associated with an enhanced NADPH-driven O2- producing capacity.	Phosphatidylcholines	65-84	mitochondrially encoded cytochrome b	Homo sapiens	32-44
8307196-6	1994	High affinity binding of FAD to cytochrome b559 relipidated with phosphatidylcholine combined with phosphatidic acid is associated with an enhanced NADPH-driven O2- producing capacity.	Phosphatidylcholines	65-84	2,4-dienoyl-CoA reductase 1	Homo sapiens	148-153
8305444-11	1994	NOESY experiments showed that the AC2 molecules forming the micelle structures have hindered motion compared to conventional short-chain phosphatidylcholine micelles.	Phosphatidylcholines	137-156	adenylate cyclase 2	Homo sapiens	34-37
8304830-5	1994	RESULTS: The human rHDL suppressed TNF-alpha production with the products having the highest fraction of phosphatidyl choline producing the greatest suppression of TNF-alpha production.	Phosphatidylcholines	105-125	tumor necrosis factor	Homo sapiens	35-44
8304830-5	1994	RESULTS: The human rHDL suppressed TNF-alpha production with the products having the highest fraction of phosphatidyl choline producing the greatest suppression of TNF-alpha production.	Phosphatidylcholines	105-125	tumor necrosis factor	Homo sapiens	164-173
8306341-6	1994	Prelabeling cells with [3H]glycerol or [3H]-choline demonstrated rapid release of [3H]phosphorylcholine and a decrease in [3H]glycerol-labeled phosphatidylcholine in response to IL-3 stimulation.	Phosphatidylcholines	143-162	interleukin 3	Homo sapiens	178-182
8306341-0	1994	Human interleukin-3 stimulates a phosphatidylcholine specific phospholipase C and protein kinase C translocation.	Phosphatidylcholines	33-52	interleukin 3	Homo sapiens	6-19
8306341-8	1994	It is thus likely that interleukin-3 is activating a phosphatidylcholine specific phospholipase C rather than a phospholipase D. Finally, genistein and herbimycin, specific tyrosine kinase inhibitors, inhibited both IL-3 induced protein kinase C translocation and the accumulation of diacylglycerol.	Phosphatidylcholines	53-72	interleukin 3	Homo sapiens	23-36
8174753-2	1994	The differential effects of inhibitors of protein kinase (PK) or tyrosine kinase (TK) on phosphatidylcholine (PC) biosynthesis in monocyte-like U937 cells were compared in pulse-chase-studies in which the cells prelabelled with [3H]choline for 30 min were chased in the absence or presence of kinase inhibitors.	Phosphatidylcholines	89-108	TXK tyrosine kinase	Homo sapiens	82-84
8174753-2	1994	The differential effects of inhibitors of protein kinase (PK) or tyrosine kinase (TK) on phosphatidylcholine (PC) biosynthesis in monocyte-like U937 cells were compared in pulse-chase-studies in which the cells prelabelled with [3H]choline for 30 min were chased in the absence or presence of kinase inhibitors.	Phosphatidylcholines	110-112	TXK tyrosine kinase	Homo sapiens	82-84
8174753-10	1994	In contrast, TK inhibitor (genistein) markedly stimulated CT and PC biosynthesis, while erbstatin and tyrphostin No.	Phosphatidylcholines	65-67	TXK tyrosine kinase	Homo sapiens	13-15
8174763-8	1994	The present results suggest that PC is a unique substrate for human intestinal ALP, which may be related to the metabolism of PC or choline as part of phosphatidylcholine.	Phosphatidylcholines	151-170	alkaline phosphatase, placental	Homo sapiens	79-82
8176620-6	1994	Combined antenatal low-dose dexamethasone and TRH significantly reduced mean lung glycogen concentration (P = .001), and increased mean disaturated phosphatidylcholine content (P &lt; .005) to better than that observed with either therapy alone, without changing mean body or lung weight.	Phosphatidylcholines	148-167	thyrotropin releasing hormone	Homo sapiens	46-49
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	78-97	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	26-32
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	78-97	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	161-167
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	206-225	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	26-32
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Phosphatidylcholines	206-225	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	161-167
8025588-5	1994	Interestingly, 90% of the sera from syphilis patients and 6% of the autoimmune patients exhibited a significant binding to platelet-activating factor (PAF), a molecule similar to the structure of phosphatidylcholine.	Phosphatidylcholines	196-215	PCNA clamp associated factor	Homo sapiens	123-149
8025588-5	1994	Interestingly, 90% of the sera from syphilis patients and 6% of the autoimmune patients exhibited a significant binding to platelet-activating factor (PAF), a molecule similar to the structure of phosphatidylcholine.	Phosphatidylcholines	196-215	PCNA clamp associated factor	Homo sapiens	151-154
8294512-4	1994	We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.	Phosphatidylcholines	183-202	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	16-22
8294482-8	1994	Repression of transcription of ITR1 also requires ongoing synthesis of phosphatidylcholine, defining an additional link between synthesis of phospholipids and regulation of inositol uptake.	Phosphatidylcholines	71-90	myo-inositol transporter ITR1	Saccharomyces cerevisiae S288C	31-35
8294426-1	1994	Binding of cytochrome c (cyt c) to cardiolipin/phosphatidylcholine (CL/PC) and phosphatidylglycerol/PC (PG/PC) liposomes was studied at neutral pH utilizing fluorescence resonance energy transfer from a membrane-incorporated pyrene phospholipid derivative to the heme of cyt c.	Phosphatidylcholines	47-66	cytochrome c, somatic	Homo sapiens	11-23
8294426-1	1994	Binding of cytochrome c (cyt c) to cardiolipin/phosphatidylcholine (CL/PC) and phosphatidylglycerol/PC (PG/PC) liposomes was studied at neutral pH utilizing fluorescence resonance energy transfer from a membrane-incorporated pyrene phospholipid derivative to the heme of cyt c.	Phosphatidylcholines	47-66	cytochrome c, somatic	Homo sapiens	25-30
8294444-1	1994	Although the site-directed C73S mutation in the ADP/ATP carrier (AAC) AAC2 gene from Saccharomyces cerevisiae produced a glycerol-positive strain, indicating that the mutant AAC is active, on isolation and reconstitution in egg yolk phosphatidylcholine, the C73S AAC had no transport activity, whereas the wild-type AAC was fully active.	Phosphatidylcholines	233-252	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	70-74
8280752-4	1994	This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT).	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Homo sapiens	116-160
7506931-1	1994	Human myelin basic protein (MBP) is shown to disrupt multilamellar phosphatidylcholine bilayers into small lipoprotein particles in a manner similar to the cytolytic peptide melittin (Dufourc, E. J., Smith, I. C. P., &amp; Dufourcq, J.	Phosphatidylcholines	67-86	myelin basic protein	Homo sapiens	6-26
7506931-1	1994	Human myelin basic protein (MBP) is shown to disrupt multilamellar phosphatidylcholine bilayers into small lipoprotein particles in a manner similar to the cytolytic peptide melittin (Dufourc, E. J., Smith, I. C. P., &amp; Dufourcq, J.	Phosphatidylcholines	67-86	myelin basic protein	Homo sapiens	28-31
8280752-4	1994	This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT).	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Homo sapiens	162-166
8280763-1	1994	Isolated Golgi apparatus, highly purified from rat liver, were found to contain an acyl transfer activity capable of restoring the acyl chains of the lysophospholipid products of the action of phospholipase A2 on phosphatidylcholine.	Phosphatidylcholines	213-232	phospholipase A2 group IB	Rattus norvegicus	193-209
8263514-8	1994	Bradykinin stimulated diacylglycerol production in neuroblastoma cells by increasing the hydrolysis of both phosphoinositides and phosphatidylcholine.	Phosphatidylcholines	130-149	kininogen 1	Homo sapiens	0-10
7864659-9	1994	The results demonstrated that lysoPC, a phospholipase A2-generated hydrolysis product of phosphatidylcholine, induced T-lymphocyte chemotaxis in vitro.	Phosphatidylcholines	89-108	phospholipase A2 group IB	Homo sapiens	40-56
7864659-10	1994	Because phosphatidylcholine is the major phospholipid in the epidermis, the activation of phospholipase A2 may result in the release of lysoPC in concentrations capable of inducing migration of T lymphocytes into the epidermis.	Phosphatidylcholines	8-27	phospholipase A2 group IB	Homo sapiens	90-106
8187205-5	1994	Fluorescent analogs of phosphatidylcholine and sphingomyelin were inserted into the surface layer of LDL and Lp(a).	Phosphatidylcholines	23-42	lipoprotein(a)	Homo sapiens	109-114
8187205-8	1994	Higher affinity for Lp(a) as compared with LDL was also observed with a fluorescent diether analog of phosphatidylcholine in native serum.	Phosphatidylcholines	102-121	lipoprotein(a)	Homo sapiens	20-25
8138720-4	1994	Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis.	Phosphatidylcholines	12-31	lipase E, hormone sensitive type	Rattus norvegicus	106-109
8138720-4	1994	Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis.	Phosphatidylcholines	12-31	lipase E, hormone sensitive type	Rattus norvegicus	149-152
8138720-4	1994	Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis.	Phosphatidylcholines	210-229	lipase E, hormone sensitive type	Rattus norvegicus	106-109
8139391-0	1994	Biphasic modulation of choline uptake and phosphatidylcholine biosynthesis by vasopressin in rat cardiac myocytes.	Phosphatidylcholines	42-61	arginine vasopressin	Rattus norvegicus	78-89
8139391-4	1994	The biosynthesis of phosphatidylcholine was also affected by vasopressin in a biphasic manner.	Phosphatidylcholines	20-39	arginine vasopressin	Rattus norvegicus	61-72
8139391-5	1994	At low concentrations of vasopressin, a general increase in cytosine triphosphate:phosphocholine cytidylyltransferase activity was observed that caused an enhanced conversion of phosphocholine to phosphatidylcholine via the cytidine diphosphocholine pathway.	Phosphatidylcholines	196-215	arginine vasopressin	Rattus norvegicus	25-36
8261513-1	1993	The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline.	Phosphatidylcholines	18-37	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-56
8264633-1	1994	In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus.	Phosphatidylcholines	114-133	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	177-180
8264633-1	1994	In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus.	Phosphatidylcholines	135-137	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	177-180
8264633-1	1994	In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus.	Phosphatidylcholines	135-137	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	279-282
8264633-7	1994	Taken together, our results show that chronic stimulation of PC hydrolysis by an unregulated PC-PLC enzyme is oncogenic to NIH 3T3 cells.	Phosphatidylcholines	61-63	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	96-99
8261513-1	1993	The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline.	Phosphatidylcholines	18-37	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	58-61
8263781-6	1993	Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells.	Phosphatidylcholines	80-99	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
8128456-9	1993	Secreted phospholipase A2 hydrolyzed phosphatidylethanolamine at 5-12 times the rate of phosphatidylcholine when the substrates were present in pure form.	Phosphatidylcholines	88-107	phospholipase A2 group IB	Homo sapiens	9-25
8288878-4	1993	The sensitivity of RIA for PAF was notably higher than that for sn-2-short-chain PAF-like phosphatidylcholines.	Phosphatidylcholines	90-110	PCNA clamp associated factor	Homo sapiens	81-84
8280053-1	1993	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a phosphatidylcholine-requiring tetrameric enzyme with two thiol groups (SH-1 and SH-2) per protomer.	Phosphatidylcholines	47-66	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
8307580-1	1993	CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells.	Phosphatidylcholines	74-93	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
8263781-6	1993	Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells.	Phosphatidylcholines	80-99	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
8263781-9	1993	It was concluded that ACh-induced esophageal contraction depends preferentially on M2 receptors, a PTX-sensitive G13 protein, phosphatidylcholine-specific PLD and production of diacylglycerol (DAG) and is independent of IP3 formation and the release of intracellular Ca++.	Phosphatidylcholines	126-145	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	155-158
8240288-0	1993	Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity.	Phosphatidylcholines	18-37	choline phosphotransferase 1	Homo sapiens	83-108
8251517-1	1993	Purified adrenocortical microsomal P-450C21 was incorporated into vesicle membranes composed of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine at a molar ratio of 5:3:1.	Phosphatidylcholines	96-115	steroid 21-hydroxylase	Bos taurus	35-43
8106172-6	1993	We conclude that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholipid flippase.	Phosphatidylcholines	83-102	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	21-25
8246981-0	1993	Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.	Phosphatidylcholines	14-33	zinc fingers and homeoboxes 2	Homo sapiens	63-66
8246981-1	1993	We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals.	Phosphatidylcholines	60-79	zinc fingers and homeoboxes 2	Homo sapiens	107-110
8246981-1	1993	We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals.	Phosphatidylcholines	81-83	zinc fingers and homeoboxes 2	Homo sapiens	107-110
8251487-1	1993	A fluorescent assay based on concentration-dependent self-quenching of the fluorescent phospholipid N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine was used to measure the rate of phospholipid exchange between taurocholate/phosphatidylcholine mixed micelles.	Phosphatidylcholines	237-256	OXA1L mitochondrial inner membrane protein	Homo sapiens	117-122
8240288-3	1993	PC biosynthesis was inhibited to one-quarter at the step catalysed by cholinephosphotransferase (CPT).	Phosphatidylcholines	0-2	choline phosphotransferase 1	Homo sapiens	70-95
8292693-1	1993	We measured serum phospholipase A2 (PLA2) activity in 39 schizophrenics, 26 psychiatric controls, and 26 normal controls using a radioenzymatic assay with phosphatidylcholine as precursor.	Phosphatidylcholines	155-174	phospholipase A2 group IB	Homo sapiens	18-34
8240288-3	1993	PC biosynthesis was inhibited to one-quarter at the step catalysed by cholinephosphotransferase (CPT).	Phosphatidylcholines	0-2	choline phosphotransferase 1	Homo sapiens	97-100
8292693-1	1993	We measured serum phospholipase A2 (PLA2) activity in 39 schizophrenics, 26 psychiatric controls, and 26 normal controls using a radioenzymatic assay with phosphatidylcholine as precursor.	Phosphatidylcholines	155-174	phospholipase A2 group IB	Homo sapiens	36-40
8293516-3	1993	The efficiency of the SOD-entrapment into the positively charged multilamellar vesicles (MLVs), comprising egg yolk phosphatidylcholine and synthetic glucosamine diesters, was enhanced by the addition of cholesterol to the membranes.	Phosphatidylcholines	116-135	superoxide dismutase 1	Homo sapiens	22-25
8298012-1	1993	The nonideal mixing of phosphatidylserine (PS) and phosphatidylcholine (PC) binary lipid mixtures was studied by computer simulation based on a model wherein the excess energy of mixing is divided between an electrostatic term and one adjustable term delta Em that includes all other nonideal interactions.	Phosphatidylcholines	51-70	surfactant protein C	Homo sapiens	72-74
8130082-0	1993	Epidermal growth factor increases 32P incorporation into phosphatidylcholine and protein kinase C activity in colon carcinoma cell line (HT29).	Phosphatidylcholines	57-76	epidermal growth factor	Homo sapiens	0-23
8242260-14	1993	The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis.	Phosphatidylcholines	252-271	protein kinase C, alpha	Rattus norvegicus	22-25
7508272-10	1993	The human serum phospholipase A2 strongly preferred E. coli membranes as substrate to the mixed micelles containing phosphatidylcholine/phosphatidylethanolamine.	Phosphatidylcholines	116-135	phospholipase A2 group IB	Homo sapiens	16-32
8268464-0	1993	Phospholipase D-mediated hydrolysis of phosphatidylcholine: role in cell signalling.	Phosphatidylcholines	39-58	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
8268464-2	1993	The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells.	Phosphatidylcholines	89-108	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64
8268464-2	1993	The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells.	Phosphatidylcholines	110-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64
8411362-0	1993	Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes.	Phosphatidylcholines	0-19	nuclear factor kappa B subunit 1	Homo sapiens	41-51
8411362-1	1993	We have tested whether breakdown of phosphatidylcholine (PC) initiated by exogenous addition of a PC-specific phospholipase C (PC-PLC) from Bacillus cereus or by endogenous overexpression of PC-PLC induces functional activation of NF-kappa B and increases human immunodeficiency virus (HIV) enhancer activity.	Phosphatidylcholines	36-55	nuclear factor kappa B subunit 1	Homo sapiens	231-241
8411362-1	1993	We have tested whether breakdown of phosphatidylcholine (PC) initiated by exogenous addition of a PC-specific phospholipase C (PC-PLC) from Bacillus cereus or by endogenous overexpression of PC-PLC induces functional activation of NF-kappa B and increases human immunodeficiency virus (HIV) enhancer activity.	Phosphatidylcholines	57-59	nuclear factor kappa B subunit 1	Homo sapiens	231-241
8411362-2	1993	PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin.	Phosphatidylcholines	0-2	nuclear factor kappa B subunit 1	Homo sapiens	64-67
8411362-2	1993	PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin.	Phosphatidylcholines	0-2	RELA proto-oncogene, NF-kB subunit	Homo sapiens	68-71
8411362-2	1993	PC-PLC-activated hydrolysis of PC was found to induce bona fide p50/p65 NF-kappa B binding activity in three different cell lines of human or murine origin.	Phosphatidylcholines	0-2	nuclear factor kappa B subunit 1	Homo sapiens	72-82
8399233-1	1993	The photobleaching process of iodopsin (a chicken red-sensitive cone visual pigment) purified in a detergent system containing CHAPS and phosphatidylcholine was investigated by means of nanosecond laser photolysis at room temperature.	Phosphatidylcholines	137-156	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	30-38
8399288-11	1993	The present study extends this work to investigate the effects of PC and PS on platelet responses to a natural agonist, thrombin.	Phosphatidylcholines	66-68	coagulation factor II, thrombin	Homo sapiens	120-128
8264152-2	1993	In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid.	Phosphatidylcholines	163-182	angiogenin	Homo sapiens	15-18
8264152-2	1993	In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid.	Phosphatidylcholines	163-182	phospholipase A2 group IB	Homo sapiens	96-112
8264152-2	1993	In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid.	Phosphatidylcholines	163-182	phospholipase A2 group IB	Homo sapiens	114-118
8397115-1	1993	The role of Ca2+ and protein kinase C (PKC) in the regulation of phosphatidylcholine-hydrolyzing phospholipase D (PLD) was investigated in angiotensin II-stimulated mesangial cells.	Phosphatidylcholines	65-84	protein kinase C, alpha	Rattus norvegicus	39-42
8397115-1	1993	The role of Ca2+ and protein kinase C (PKC) in the regulation of phosphatidylcholine-hydrolyzing phospholipase D (PLD) was investigated in angiotensin II-stimulated mesangial cells.	Phosphatidylcholines	65-84	angiotensinogen	Rattus norvegicus	139-153
8286511-6	1993	RESULTS: All three cytokines, particularly TNF-alpha, inhibited the incorporation of D-glucose uniformly labelled with 14C (D-(U-14C) glucose) into phosphatidylcholine.	Phosphatidylcholines	148-167	tumor necrosis factor	Homo sapiens	43-52
8286511-8	1993	When palmitate uniformly labelled with 14C was used as the radiolabelled precursor, TNF-alpha stimulated the synthesis of both triacylglycerol and phosphatidylcholine, neither of which was affected by IL-1 or IL-6.	Phosphatidylcholines	147-166	tumor necrosis factor	Homo sapiens	84-93
8286512-6	1993	RESULTS: TNF-alpha decreased the incorporation of both D-(U-14C) glucose and (U-14C) palmitate into phospholipid fractions, particularly phosphatidylcholine, in both healthy lung tissue and that from patients with lung cancer.	Phosphatidylcholines	137-156	tumor necrosis factor	Homo sapiens	9-18
8227406-6	1993	With phosphatidylserine:phosphatidylcholine vesicles at a concentration of 1 microM:2 microM, beta 2 GPI began to inhibit the reaction at a concentration of 15 nM, and at 4 microM (the normal plasma concentration) the activation of protein C was reduced to 40%.	Phosphatidylcholines	24-43	apolipoprotein H	Homo sapiens	94-104
8399325-5	1993	(4) The pool sizes of the intermediate metabolic products of the CDP-choline-pathway for the synthesis of phosphatidylcholine were also higher in the cells isolated from exposed animals.	Phosphatidylcholines	106-125	cut-like homeobox 1	Rattus norvegicus	65-68
7692845-3	1993	Phosphatidylcholine, lysophosphatidylcholine, and phosphatidylethanolamine dose-dependently enhanced the enzyme activity up to 3 fold in the presence of Ca2+, calmodulin, NADPH, FAD, and (6R)-5,6,7,8-tetrahydrobiopterin.	Phosphatidylcholines	0-19	calmodulin	Bos taurus	159-169
8376375-7	1993	Kinetic studies suggested that: 1) LCAT binds better to substrate vesicles which contain SPH; 2) SPH competes with PC in binding to the active site of the enzyme; and 3) SPH is a more powerful competitive inhibitor than a diether analog of PC.	Phosphatidylcholines	115-117	lecithin-cholesterol acyltransferase	Homo sapiens	35-39
8239319-0	1993	Comparative effects of aging process on phosphatidylcholine biosynthesis pathway: a key role for CTP-phosphocholine cytidylyltransferase?	Phosphatidylcholines	40-59	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	97-136
8239304-2	1993	Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle.	Phosphatidylcholines	50-69	cut-like homeobox 1	Rattus norvegicus	102-105
8239304-2	1993	Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle.	Phosphatidylcholines	71-73	cut-like homeobox 1	Rattus norvegicus	102-105
8376375-8	1993	The ability of various lipoproteins to act as substrates for purified LCAT varied inversely with the SPH/PC ratio.	Phosphatidylcholines	105-107	lecithin-cholesterol acyltransferase	Homo sapiens	70-74
8237421-10	1993	Furthermore, VIP treatment, and the concomitant cAMP-accumulation, potentiates the acetylcholine induced phosphatidylcholine hydrolysis, demonstrating a new type of interaction between the classical transmitter acetylcholine and the co-stored neuropeptide VIP.	Phosphatidylcholines	105-124	vasoactive intestinal peptide	Rattus norvegicus	256-259
8396134-3	1993	All of these reactions required activation by human apolipoprotein A-I, suggesting that this activation leads to the deacylation of phosphatidylcholine.	Phosphatidylcholines	132-151	apolipoprotein A1	Homo sapiens	52-70
8396134-5	1993	Lysophosphatidylcholine that was endogenously generated by deacylation of phosphatidylcholine in the first step of the LCAT reaction was also a good acyl acceptor, showing that the reaction is always partly "idling."	Phosphatidylcholines	4-23	lecithin-cholesterol acyltransferase	Homo sapiens	119-123
8370463-2	1993	The phospholipid topology of the outer membrane of intact rat liver mitochondria and derived outer membrane vesicles was investigated by determining the accessible pool of the various phospholipid classes towards phospholipase A2, a phosphatidylcholine-specific transfer protein and by chemical labeling using trinitrobenzene sulfonic acid.	Phosphatidylcholines	233-252	phospholipase A2 group IB	Rattus norvegicus	213-229
8237421-10	1993	Furthermore, VIP treatment, and the concomitant cAMP-accumulation, potentiates the acetylcholine induced phosphatidylcholine hydrolysis, demonstrating a new type of interaction between the classical transmitter acetylcholine and the co-stored neuropeptide VIP.	Phosphatidylcholines	105-124	vasoactive intestinal peptide	Rattus norvegicus	13-16
8373761-0	1993	Polymerizable phosphatidylcholines: importance of phospholipid motions for optimum phospholipase A2 and C activity.	Phosphatidylcholines	14-34	phospholipase A2 group IB	Homo sapiens	83-99
8379928-6	1993	As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages.	Phosphatidylcholines	64-83	Rous sarcoma oncogene	Mus musculus	110-113
8379928-6	1993	As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages.	Phosphatidylcholines	64-83	Rous sarcoma oncogene	Mus musculus	183-186
8379928-6	1993	As both arachidonic acid and alkyl-lysoPC are incorporated into phosphatidylcholine (PC), the substrate for v-Src-induced PLD activity, these data suggest that the PLD activated by v-Src can distinguish PCs lacking arachidonic acid and ether linkages.	Phosphatidylcholines	39-41	Rous sarcoma oncogene	Mus musculus	110-113
8379928-8	1993	Taken together, these data suggest that v-Src activates a PKC-independent PLD activity that is specific for a subpopulation of PC and distinct from the PLD activity induced by PKC activity induced by phorbol esters.	Phosphatidylcholines	127-129	Rous sarcoma oncogene	Mus musculus	42-45
8379928-9	1993	The diacylglycerol produced from PC by the action of the v-Src-induced PLD may therefore be responsible for the activation of PKC by v-Src.	Phosphatidylcholines	33-35	Rous sarcoma oncogene	Mus musculus	59-62
8379928-9	1993	The diacylglycerol produced from PC by the action of the v-Src-induced PLD may therefore be responsible for the activation of PKC by v-Src.	Phosphatidylcholines	33-35	Rous sarcoma oncogene	Mus musculus	135-138
8344945-2	1993	Phosphatidylethanolamine N-methyltransferase catalyzes the synthesis of phosphatidylcholine from phosphatidylethanolamine and is most active in liver.	Phosphatidylcholines	72-91	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	0-44
8231655-1	1993	The modulation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis by sulfur-substituted fatty acid analogues has been investigated in rats.	Phosphatidylcholines	18-37	procollagen C-endopeptidase enhancer	Rattus norvegicus	39-41
8347671-0	1993	Spin-label studies on phosphatidylcholine-polar carotenoid membranes: effects of alkyl-chain length and unsaturation.	Phosphatidylcholines	22-41	spindlin 1	Homo sapiens	0-4
8347671-1	1993	Spin-labeling methods were used to study the structure and dynamic properties of phosphatidylcholine (PC)-dihydroxycarotenoid membranes as a function of phospholipid alkyl chain length, alkyl chain saturation, temperature and mol fraction of carotenoids.	Phosphatidylcholines	81-100	spindlin 1	Homo sapiens	0-4
8347671-1	1993	Spin-labeling methods were used to study the structure and dynamic properties of phosphatidylcholine (PC)-dihydroxycarotenoid membranes as a function of phospholipid alkyl chain length, alkyl chain saturation, temperature and mol fraction of carotenoids.	Phosphatidylcholines	102-104	spindlin 1	Homo sapiens	0-4
8347671-4	1993	(2) The abrupt changes of spin-label motion observed at the main-phase transition of the saturated PC membranes are broadened and shifted to lower temperatures.	Phosphatidylcholines	99-101	spindlin 1	Homo sapiens	26-30
8347671-6	1993	(3) In fluid-phase PC membranes possessing short alkyl chains (12-14 carbons), the activation energy of the rotational diffusion of 16-doxylstearic acid spin label (16-SASL) is significantly lower at a carotenoid concentration of 10 mol%.	Phosphatidylcholines	19-21	spindlin 1	Homo sapiens	153-157
8241408-10	1993	A previously proposed universal relation for the perpendicular component of the rotational diffusion tensor, R perpendicular, for CSL in PC/cholesterol mixtures (i.e., R perpendicular = R0 perpendicular exp(-AS2chol/RT)) is confirmed.	Phosphatidylcholines	137-139	chorionic somatomammotropin hormone like 1	Homo sapiens	130-133
8403234-10	1993	Although the PL composition of the cells remained essentially unaffected, our study shows that chronic treatment of U937 cells with n - 3 PUFA (20:5) depressed PC and PE synthesis, and 18:3 and 20:4 also caused inhibition of PE synthesis.	Phosphatidylcholines	160-162	pumilio RNA binding family member 3	Homo sapiens	138-142
7900958-4	1993	Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined.	Phosphatidylcholines	88-107	heparan sulfate proteoglycan 2	Homo sapiens	117-120
8368329-0	1993	Pulmonary surfactant protein A-mediated uptake of phosphatidylcholine by alveolar type II cells.	Phosphatidylcholines	50-69	surfactant protein A1	Homo sapiens	0-30
8368329-1	1993	Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated.	Phosphatidylcholines	57-76	surfactant protein A1	Homo sapiens	0-30
8368329-1	1993	Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated.	Phosphatidylcholines	57-76	surfactant protein A1	Homo sapiens	32-36
8368329-1	1993	Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated.	Phosphatidylcholines	78-80	surfactant protein A1	Homo sapiens	0-30
8368329-1	1993	Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated.	Phosphatidylcholines	78-80	surfactant protein A1	Homo sapiens	32-36
8368329-6	1993	Phosphatidylcholine that had been incorporated into lamellar bodies remained largely intact when SP-A was present.	Phosphatidylcholines	0-19	surfactant protein A1	Homo sapiens	97-101
8393878-3	1993	Thus, other signal transduction pathways that hydrolyze phosphatidylcholine (PtdCho) or phosphatidylethanolamine (PtdEth) and form DG and phosphatidic acids (PA) through either PLC or phospholipase D (PLD) may also mediate PAF-stimulated cellular responses.	Phosphatidylcholines	56-75	PCNA clamp associated factor	Rattus norvegicus	223-226
8344304-1	1993	In the present study the effect of changing the fatty acyl moiety of phosphatidylcholine from dilauroyl to distearoyl on the kinetic parameters of O-dealkylation of alkoxyresorufins and ethoxycoumarin dependent on reconstituted cytochromes P-450 IA1 and IIB1 has been investigated.	Phosphatidylcholines	69-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	240-245
8344304-1	1993	In the present study the effect of changing the fatty acyl moiety of phosphatidylcholine from dilauroyl to distearoyl on the kinetic parameters of O-dealkylation of alkoxyresorufins and ethoxycoumarin dependent on reconstituted cytochromes P-450 IA1 and IIB1 has been investigated.	Phosphatidylcholines	69-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	254-258
7920899-4	1993	Our previous data suggested that phosphatidylcholine which was sonicated with cholesteryl oleate as a substrate may play a crucial role in the regulation of CEase in rat adrenal.	Phosphatidylcholines	33-52	carboxyl ester lipase	Homo sapiens	157-162
7920899-6	1993	Acid CEase in normal tissue was increased in a dose-dependent manner by phosphatidylcholine, but not in the adenoma or hyperplasia tissues.	Phosphatidylcholines	72-91	carboxyl ester lipase	Homo sapiens	5-10
8392931-4	1993	In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA.	Phosphatidylcholines	44-63	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
8392931-4	1993	In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA.	Phosphatidylcholines	65-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
8392931-5	1993	We found in bradykinin-stimulated human fibroblasts that PLD mediates transphosphatidylation from PC (donor) to the endogenous "alcohol" DG (acceptor), yielding bis(1,2-diacylglycero)-3-sn-phosphate (bisphosphatidic acid; bisPA).	Phosphatidylcholines	98-100	kininogen 1	Homo sapiens	12-22
8392931-5	1993	We found in bradykinin-stimulated human fibroblasts that PLD mediates transphosphatidylation from PC (donor) to the endogenous "alcohol" DG (acceptor), yielding bis(1,2-diacylglycero)-3-sn-phosphate (bisphosphatidic acid; bisPA).	Phosphatidylcholines	98-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
8503884-0	1993	Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells.	Phosphatidylcholines	0-19	angiotensinogen	Homo sapiens	81-95
8375418-5	1993	The association of apolipoprotein A-I with phosphatidylcholine liposomes resulted in a more than two-fold increase in cholesterol efflux compared to free apolipoprotein A-I, while association of apolipoproteins A-II and C-I with phosphatidylcholine liposomes resulted in a very limited increase in cholesterol efflux above that achieved by the free apolipoproteins.	Phosphatidylcholines	43-62	apolipoprotein A1	Homo sapiens	19-37
8375418-5	1993	The association of apolipoprotein A-I with phosphatidylcholine liposomes resulted in a more than two-fold increase in cholesterol efflux compared to free apolipoprotein A-I, while association of apolipoproteins A-II and C-I with phosphatidylcholine liposomes resulted in a very limited increase in cholesterol efflux above that achieved by the free apolipoproteins.	Phosphatidylcholines	43-62	apolipoprotein A1	Homo sapiens	154-172
7686368-1	1993	Monoclonal antibodies (mAbs) have been used to study structure-function relationships of (R)-3-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30), a lipid-requiring mitochondrial membrane enzyme with an absolute and specific requirement for phosphatidylcholine (PC) for enzymic activity.	Phosphatidylcholines	240-259	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	126-129
7686368-6	1993	Further, for BDH in bilayers containing PC, the C-terminus is protected from carboxy-peptidase cleavage, whereas in bilayers devoid of PC the C-terminus is cleaved, and subsequent activation by PC is precluded.	Phosphatidylcholines	40-42	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	13-16
7686368-7	1993	We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme.	Phosphatidylcholines	152-154	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	40-43
7686368-7	1993	We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme.	Phosphatidylcholines	152-154	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	199-202
7686368-7	1993	We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme.	Phosphatidylcholines	152-154	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	199-202
7686368-7	1993	We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme.	Phosphatidylcholines	248-250	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	40-43
7686368-7	1993	We conclude that: (1) the C-terminus of BDH is essential for enzymic activity, consistent with the prediction, from primary sequence analysis, that the PC-binding site is in the C-terminal domain of BDH; and (2) the allosteric activation of BDH by PC in bilayers protects the C-terminus from carboxypeptidase cleavage, indicative of a PC-induced conformational change in the enzyme.	Phosphatidylcholines	248-250	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	40-43
8504157-8	1993	The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	349-368	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	177-180
8504093-9	1993	This enhancement of HL activity occurred at about the same cholesterol concentration as the restoration of triacylglycerol hydrolysis observed for the triacylglycerol/phosphatidylcholine/cholesterol films.	Phosphatidylcholines	167-186	lipase C, hepatic type	Rattus norvegicus	20-22
8392813-0	1993	Regulation of phosphatidylcholine synthesis in fetal type II cells by CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	14-33	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	70-109
8392813-3	1993	The developmental profile of the enzymes of the CDP-choline pathway suggests that CTP:choline-phosphate cytidylyltransferase catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells.	Phosphatidylcholines	169-188	cut-like homeobox 1	Rattus norvegicus	48-51
8392813-7	1993	We speculate that either a subcellular translocation of CTP:phosphocholine cytidylyltransferase from cytosol to microsomes or an increase in cytidylyltransferase gene expression are responsible for the developmental increase of de novo phosphatidylcholine synthesis by fetal type II cells.	Phosphatidylcholines	236-255	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	56-95
7686941-8	1993	These results indicate that the phosphatidylcholine-specific PLD pathway is the main pathway for the production of 1,2-DG in SCF-stimulated rat peritoneal mast cells.	Phosphatidylcholines	32-51	KIT ligand	Rattus norvegicus	125-128
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	Phosphatidylcholines	60-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	Phosphatidylcholines	60-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	Phosphatidylcholines	81-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	Phosphatidylcholines	81-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
8503884-10	1993	Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor.	Phosphatidylcholines	87-93	angiotensinogen	Homo sapiens	9-23
8324883-4	1993	CDP-choline also did not antagonize the effect of hypoxia on phosphatidylcholine synthesis; rather it accentuated the hypoxia-induced reductions in cellular phosphocholine and phosphatidylcholine biosynthesis.	Phosphatidylcholines	176-195	cut-like homeobox 1	Rattus norvegicus	0-3
8324883-5	1993	These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis.	Phosphatidylcholines	159-178	cut-like homeobox 1	Rattus norvegicus	60-63
8324883-5	1993	These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis.	Phosphatidylcholines	343-362	cut-like homeobox 1	Rattus norvegicus	60-63
8503884-10	1993	Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor.	Phosphatidylcholines	87-93	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	74-77
8099446-1	1993	2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC 3.1.1.4), significantly potentiate the differentiation of HL-60 cells to macrophages that is induced by either a membrane-permeant diacylglycerol or a phorbol ester.	Phosphatidylcholines	6-25	phospholipase A2 group IB	Homo sapiens	173-189
8514863-4	1993	The major cytosolic phospholipase A2 isoform preferentially hydrolyzes plasmalogen substrate, possesses a pH optimum of 7.0, and is chromatographically resolvable from a minor cytosolic calcium-independent phospholipase A2 isoform that hydrolyzes plasmenylcholine and phosphatidylcholine substrates at similar rates and possesses a pH optimum of 8.5.	Phosphatidylcholines	268-287	phospholipase A2 group IVA	Homo sapiens	10-36
8514863-4	1993	The major cytosolic phospholipase A2 isoform preferentially hydrolyzes plasmalogen substrate, possesses a pH optimum of 7.0, and is chromatographically resolvable from a minor cytosolic calcium-independent phospholipase A2 isoform that hydrolyzes plasmenylcholine and phosphatidylcholine substrates at similar rates and possesses a pH optimum of 8.5.	Phosphatidylcholines	268-287	phospholipase A2 group IB	Homo sapiens	20-36
8389049-1	1993	In human non-small cell lung cancer cells (PC-14) exposed to DHA-VC for 24 hr, a dose-dependent increase in phosphatidylcholine-specific phospholipase C (PC-PLC) activity was seen.	Phosphatidylcholines	108-127	heparan sulfate proteoglycan 2	Homo sapiens	157-160
8388334-1	1993	Circular dichroism (CD) and acrylamide quenching studies of Na+,K(+)-ATPase from human placenta showed that its incorporation into phosphatidylcholine vesicles increased the enzymic activity by 55%.	Phosphatidylcholines	131-150	dynein axonemal heavy chain 8	Homo sapiens	69-75
8499444-6	1993	Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC.	Phosphatidylcholines	262-281	annexin A5	Homo sapiens	143-152
8388718-1	1993	As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine.	Phosphatidylcholines	66-85	cytochrome c, somatic	Homo sapiens	165-177
8388718-1	1993	As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine.	Phosphatidylcholines	66-85	cytochrome c, somatic	Homo sapiens	179-184
8388718-1	1993	As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine.	Phosphatidylcholines	222-241	cytochrome c, somatic	Homo sapiens	165-177
8388718-1	1993	As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine.	Phosphatidylcholines	222-241	cytochrome c, somatic	Homo sapiens	179-184
8388718-7	1993	For comparison we also studied the effects of sphingosine on the phospholipase A2 catalyzed hydrolysis of the pyrene-labeled acidic alkylacyl phospholipid analog 1-octacosanyl-2-[6-(pyren-1-yl)]hexanoyl-sn-glycero-3- phosphatidylmethanol (C28-O-PHPM) and the corresponding phosphatidylcholine (C28-O-PHPC).	Phosphatidylcholines	273-292	phospholipase A2 group IB	Homo sapiens	65-81
8499444-6	1993	Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC.	Phosphatidylcholines	283-285	annexin A5	Homo sapiens	143-152
8499444-6	1993	Calculated concentrations of Ca2+ near the surface of negatively charged vesicles suggested that the exposure of tryptophan by Ca2+ binding to annexin V was sufficient for binding of the protein to all vesicles tested, including those composed of oleic acid and phosphatidylcholine (PC), but not to those composed of pure PC.	Phosphatidylcholines	322-324	annexin A5	Homo sapiens	143-152
8504138-1	1993	The activity of soluble phospholipase A2 to hydrolyze phosphatidylcholine vesicles increases abruptly after a lag time of several minutes.	Phosphatidylcholines	54-73	phospholipase A2 group IB	Homo sapiens	24-40
8364491-1	1993	The influence of phosphatidylcholine liposomes on the tryptic digestion of insulin was studied to obtain basic information on the interaction between liposomes and peptides or proteins.	Phosphatidylcholines	17-36	insulin	Homo sapiens	75-82
8485141-5	1993	The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles.	Phosphatidylcholines	337-339	annexin A5	Homo sapiens	161-170
8485141-5	1993	The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles.	Phosphatidylcholines	337-339	annexin A5	Homo sapiens	304-313
8485141-5	1993	The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles.	Phosphatidylcholines	441-443	annexin A5	Homo sapiens	161-170
8485141-5	1993	The amount of phospholipid vesicles bound by annexin IN-VC on the planar bilayer is proportional to its surface coverage and can be inhibited by coadsorption of annexin V on the planar bilayer or by shielding the phospholipid surface of the vesicles with blood coagulation factor Va. Annexin IN-VC, like annexin V, does not bind to pure PC bilayers, but its adsorption on anionic phospholipid bilayers brings about the capacity to bind pure PC vesicles.	Phosphatidylcholines	441-443	annexin A5	Homo sapiens	304-313
8387776-2	1993	PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol.	Phosphatidylcholines	74-93	phospholipase C delta 1	Homo sapiens	0-9
8387776-2	1993	PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol.	Phosphatidylcholines	95-97	phospholipase C delta 1	Homo sapiens	0-9
8387776-2	1993	PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol.	Phosphatidylcholines	134-136	phospholipase C delta 1	Homo sapiens	0-9
8387776-7	1993	These showed that 50% binding of PLC delta occurred at a level of 0.9 nmol/ml PIP2 with 80 nmol/ml PC; at 2.2 nmol/ml PIP2 with 170 nmol/ml PS; at 4.2 nmol/ml PIP2 with 320 nmol/ml PI; and at 0.26 nmol/ml PIP2 with 20 nmol/ml total liver phospholipids.	Phosphatidylcholines	99-101	phospholipase C delta 1	Homo sapiens	33-42
8481388-10	1993	In addition to the PLA2 and lyso PLA activities, we report that cPLA2 displays a relatively low, CoA-independent transacylase activity which produces phosphatidylcholine from lysophosphatidylcholine substrate.	Phosphatidylcholines	150-169	phospholipase A2 group IVA	Homo sapiens	64-69
8316043-0	1993	Phosphatidylcholine as substrate for human pancreatic phospholipase A2.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	54-70
8316043-2	1993	The long-chain phosphatidylcholine/sodium cholate aqueous system as substrate for human pancreatic phospholipase A2 (PLA2) was investigated.	Phosphatidylcholines	15-34	phospholipase A2 group IB	Homo sapiens	99-115
8316043-2	1993	The long-chain phosphatidylcholine/sodium cholate aqueous system as substrate for human pancreatic phospholipase A2 (PLA2) was investigated.	Phosphatidylcholines	15-34	phospholipase A2 group IB	Homo sapiens	117-121
8316043-10	1993	Phosphatidylcholine was preferred as substrate for human PLA2 when present in large mixed disc-like bile salt micelles.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	57-61
8324886-7	1993	The infusion of the same dose of phosphatidylcholine without apoA-I was significantly less efficacious.	Phosphatidylcholines	33-52	apolipoprotein A-I	Oryctolagus cuniculus	61-67
8387269-4	1993	However, when phosphatidylcholine levels were decreased by incubation with phospholipase A2 (PLA2), there was no significant redistribution of cytidylyltransferase activity.	Phosphatidylcholines	14-33	phospholipase A2 group IB	Rattus norvegicus	75-91
8386549-2	1993	The integrated intensities of the saturation transfer EPR spectra from spin-labelled phosphatidylcholine are linearly dependent on the protein/lipid ratio, and correspond to a fixed stoichiometry of approximately 11 lipids per monomer associated with the protein in the gel phase.	Phosphatidylcholines	85-104	spindlin 1	Homo sapiens	71-75
8386549-3	1993	The normalized saturation transfer intensities of spin-labelled phosphatidic acid, on the other hand, display a non-linear dependence on the protein/lipid ratio that can be described well by a selectivity for interaction with the protein in the gel phase with an average association constant relative to phosphatidylcholine of approx.	Phosphatidylcholines	304-323	spindlin 1	Homo sapiens	50-54
8387269-4	1993	However, when phosphatidylcholine levels were decreased by incubation with phospholipase A2 (PLA2), there was no significant redistribution of cytidylyltransferase activity.	Phosphatidylcholines	14-33	phospholipase A2 group IB	Rattus norvegicus	93-97
8387269-5	1993	With PLA2 the concentration of phosphatidylethanolamine, as well as of phosphatidylcholine, was significantly decreased.	Phosphatidylcholines	71-90	phospholipase A2 group IB	Rattus norvegicus	5-9
8389981-2	1993	The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT).	Phosphatidylcholines	43-62	cholinephosphotransferase 1	Cavia porcellus	150-175
8384876-5	1993	This reduction in rotational mobility is also found with purified squid rhodopsin reconstituted in egg phosphatidylcholine and in urea-washed outer segment membranes which have been treated with endoprotease-V8 to remove the C-terminal extension of squid rhodopsin.	Phosphatidylcholines	103-122	rhodopsin	Bos taurus	72-81
8389981-2	1993	The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT).	Phosphatidylcholines	43-62	cholinephosphotransferase 1	Cavia porcellus	177-180
7951508-4	1993	Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine.	Phosphatidylcholines	122-141	carboxyl ester lipase	Rattus norvegicus	23-28
8466950-8	1993	These findings suggest that phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase is catalyzed by lysosomal phospholipase A1.	Phosphatidylcholines	28-47	lipase H	Homo sapiens	121-137
8466950-0	1993	Lysosomal phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase: specificity for the sn-1 fatty acid of the donor and co-purification with phospholipase A1.	Phosphatidylcholines	10-29	lipase H	Homo sapiens	152-168
7951508-4	1993	Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine.	Phosphatidylcholines	215-234	carboxyl ester lipase	Rattus norvegicus	23-28
7951508-5	1993	We have already reported that phosphatidylcholine is an important factor for the regulation of adrenal CEase.	Phosphatidylcholines	30-49	carboxyl ester lipase	Rattus norvegicus	103-108
7951508-4	1993	Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine.	Phosphatidylcholines	215-234	carboxyl ester lipase	Rattus norvegicus	23-28
8514651-1	1993	Hamycin incorporated into liposomes containing phosphatidylcholine (SPC) and phosphatidic acid (PA) had reduced toxicity and an enhanced antifungal activity in experimental aspergillosis in balb/c mice.	Phosphatidylcholines	47-66	sparse coat	Mus musculus	68-71
7951508-6	1993	Therefore, the present studies show that apoproteins as well as phosphatidylcholine may be important factors for the regulation of adrenal CEase.	Phosphatidylcholines	64-83	carboxyl ester lipase	Rattus norvegicus	139-144
8386623-6	1993	Mixtures of phosphatidylcholine/phosphatidylserine or phospholipids/phosphatidylserine, in ratios of 1-4, increased the insulin-induced tyrosine kinase activation in a dose-dependent manner.	Phosphatidylcholines	12-31	insulin	Homo sapiens	120-127
8462457-10	1993	In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis.	Phosphatidylcholines	89-108	coagulation factor II	Rattus norvegicus	13-21
8462457-10	1993	In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis.	Phosphatidylcholines	193-212	coagulation factor II	Rattus norvegicus	13-21
8462457-10	1993	In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis.	Phosphatidylcholines	193-212	angiotensinogen	Rattus norvegicus	156-170
8514423-5	1993	In SP, PAF-AH-like activity was Ca(++)-independent, acid and heat labile, stable to freezing, not inhibited by phosphatidylcholine, but was inhibited by 10 mM disopropylfluorophosphate (DFP) and 13 mM phenylmethylsulfonylfluoride (PMSF).	Phosphatidylcholines	111-130	phospholipase A2 group VII	Homo sapiens	7-13
8455032-6	1993	The cell-specific translocation of MARCKS appears to correlate with previously demonstrated differential effects of phorbol esters on stimulation of phosphatidylcholine turnover in these two cell lines.	Phosphatidylcholines	149-168	myristoylated alanine rich protein kinase C substrate	Mus musculus	35-41
8444905-6	1993	Activation of endogenous phospholipase A2 by mellitin in vivo or hydrolysis of phosphatidylcholine by purified phospholipase A2 in vitro inhibited PDGF receptor autophosphorylation similar to that of purified fatty acids.	Phosphatidylcholines	79-98	phospholipase A2 group IB	Homo sapiens	111-127
8457575-5	1993	The maximum fraction of spin-labeled phospholipids translocated to the inner membrane layer was 84% for phosphatidylserine, 65% for phosphatidylethanolamine, 20-40% for phosphatidylcholine, and below 20% for sphingomyelin.	Phosphatidylcholines	169-188	spindlin 1	Homo sapiens	24-28
8383672-4	1993	The stimulation of phosphatidylcholine synthesis was correlated with a decrease in phosphocholine and an increase in CDP-choline, indicating that cytidylyltransferase is regulatory under these conditions.	Phosphatidylcholines	19-38	cut like homeobox 1	Homo sapiens	117-120
8461337-10	1993	These and previous data suggest that the stimulatory effect of ATP on phosphatidylcholine secretion in type II cells is mediated by three signal-transduction mechanisms: activation of cAMP-dependent protein kinase; activation of protein kinase C; and a calmodulin-dependent mechanism.	Phosphatidylcholines	70-89	calmodulin 1	Rattus norvegicus	253-263
8448194-6	1993	Similar studies were performed with S-100a interacting with cardiolipin, phosphatidylserine or egg phosphatidylcholine, both in absence and in presence of 2 mM Ca2+.	Phosphatidylcholines	99-118	S100 calcium binding protein A1	Homo sapiens	36-42
8436962-5	1993	GCP phospholipase A2 (PLA2) activity was demonstrated using [3H]-or [14C]AA-phosphatidylcholine (PC) or -PI as the substrate in vitro and GCPs or a cytosolic GCP extract as the source of enzyme.	Phosphatidylcholines	76-95	phospholipase A2 group IB	Rattus norvegicus	4-20
8436962-5	1993	GCP phospholipase A2 (PLA2) activity was demonstrated using [3H]-or [14C]AA-phosphatidylcholine (PC) or -PI as the substrate in vitro and GCPs or a cytosolic GCP extract as the source of enzyme.	Phosphatidylcholines	76-95	phospholipase A2 group IB	Rattus norvegicus	22-26
8464355-0	1993	Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment.	Phosphatidylcholines	68-87	linoleate 9S-lipoxygenase-4	Glycine max	167-179
8431438-0	1993	Effects of phosphatidylcholine fatty acyl chain length on calcium binding and other functions of the (Ca(2+)-Mg2+)-ATPase.	Phosphatidylcholines	11-30	dynein axonemal heavy chain 8	Homo sapiens	115-121
8384040-8	1993	Reconstitution of the isolated skeletal muscle SR Ca2+ ATPase in phosphatidylcholine membranes in the presence of PLN using the freezing and thawing technique yielded a preparation with lower Ca(2+)-dependent ATPase activity.	Phosphatidylcholines	65-84	carbonic anhydrase 2	Homo sapiens	50-53
8431438-2	1993	The stoichiometry of Ca2+ binding to the ATPase is also sensitive to fatty acyl chain length, changing from the normal two Ca2+ ions bound per ATPase molecule to one Ca2+ ion bound for the ATPase reconstituted with phosphatidylcholines of chain lengths C12, C14, or C24.	Phosphatidylcholines	215-235	dynein axonemal heavy chain 8	Homo sapiens	41-47
8431438-3	1993	For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase.	Phosphatidylcholines	45-65	dynein axonemal heavy chain 8	Homo sapiens	8-14
8431438-3	1993	For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase.	Phosphatidylcholines	45-65	dynein axonemal heavy chain 8	Homo sapiens	415-421
8441394-0	1993	Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1.	Phosphatidylcholines	0-19	colony stimulating factor 1 (macrophage)	Mus musculus	105-132
8441394-1	1993	Stimulation of diglyceride production via phospholipase C (PLC) hydrolysis of phosphatidylcholine was an early event in the mitogenic action of colony-stimulating factor 1 (CSF-1) in the murine macrophage cell line BAC1.2F5 and was followed by a second phase of diglyceride production that persisted throughout the G1 phase of the cell cycle.	Phosphatidylcholines	78-97	colony stimulating factor 1 (macrophage)	Mus musculus	144-171
8441394-1	1993	Stimulation of diglyceride production via phospholipase C (PLC) hydrolysis of phosphatidylcholine was an early event in the mitogenic action of colony-stimulating factor 1 (CSF-1) in the murine macrophage cell line BAC1.2F5 and was followed by a second phase of diglyceride production that persisted throughout the G1 phase of the cell cycle.	Phosphatidylcholines	78-97	colony stimulating factor 1 (macrophage)	Mus musculus	173-178
8382903-1	1993	CTP:phosphocholine cytidylyltransferase (CT) is a key regulatory enzyme in phosphatidylcholine biosynthesis.	Phosphatidylcholines	75-94	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
8431438-3	1993	For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase.	Phosphatidylcholines	45-64	dynein axonemal heavy chain 8	Homo sapiens	8-14
8431438-1	1993	The ATPase activity of the (Ca(2+)-Mg2+)-ATPase purified from skeletal muscle sarcoplasmic reticulum and reconstituted into phosphatidylcholine bilayers of defined composition depends on the fatty acyl chain length of the surrounding phospholipid.	Phosphatidylcholines	124-143	dynein axonemal heavy chain 8	Homo sapiens	4-10
8431438-3	1993	For the ATPase reconstituted with mixture of phosphatidylcholines where one phosphatidylcholine supports a Ca2+ binding stoichiometry of two and the other a stoichiometry of one, a highly cooperative change in binding stoichiometry with change in phospholipid composition is observed, suggesting that the effects of phospholipids follow from binding to a large number of sites at the lipid-protein interface of the ATPase.	Phosphatidylcholines	45-64	dynein axonemal heavy chain 8	Homo sapiens	415-421
8431438-5	1993	Effects of short-chain phosphatidylcholines on Ca2+ binding stoichiometry and on ATPase activity can be reversed by addition of androstenol, oleic acid, methyl oleate, or oleyl alcohol but these molecules have no effect on the ATPase reconstituted with dinervonylphosphatidylcholine (C24:1).	Phosphatidylcholines	23-43	dynein axonemal heavy chain 8	Homo sapiens	81-87
8431438-5	1993	Effects of short-chain phosphatidylcholines on Ca2+ binding stoichiometry and on ATPase activity can be reversed by addition of androstenol, oleic acid, methyl oleate, or oleyl alcohol but these molecules have no effect on the ATPase reconstituted with dinervonylphosphatidylcholine (C24:1).	Phosphatidylcholines	23-43	dynein axonemal heavy chain 8	Homo sapiens	227-233
8431438-6	1993	For the ATPase reconstituted with phosphatidylcholines with chain lengths between C16 and C22, release of the two bound Ca2+ ions is sequential, with release of the second Ca2+ being inhibited by high concentrations of Ca2+ in the bathing medium.	Phosphatidylcholines	34-54	dynein axonemal heavy chain 8	Homo sapiens	8-14
8431438-1	1993	The ATPase activity of the (Ca(2+)-Mg2+)-ATPase purified from skeletal muscle sarcoplasmic reticulum and reconstituted into phosphatidylcholine bilayers of defined composition depends on the fatty acyl chain length of the surrounding phospholipid.	Phosphatidylcholines	124-143	dynein axonemal heavy chain 8	Homo sapiens	41-47
8428938-6	1993	265, 8610-8617) and demonstrated that all apoA-I variants except apoA-I(Lys107--&gt;0) form discoidal HDL particles with phosphatidylcholine analogues indistinguishable from normal apoA-I (Jonas, A., von Eckardstein, A., Kezdy, K. E., Steinmetz, A., and Assmann, G. (1991) J.	Phosphatidylcholines	121-140	apolipoprotein A-I	Mus musculus	42-48
8431455-3	1993	Net intervesicular transfer of the lipo-gastrins to phosphatidyl-choline model bilayers occurs at high rates whereby the chain length of the gastrin lipid moiety was found to affect the transfer rate more decisively than the nature of the acceptor vesicle.	Phosphatidylcholines	52-72	gastrin	Homo sapiens	40-47
8431455-5	1993	Embedment of the lipo-gastrins in phosphatidylcholine bilayers at high lipid/gastrin ratios as mimicry of the cell membrane bound state does not result in onset of ordered structure, but leads to full exposure of the gastrin in essentially randomly coiled form at the water/lipid interface.	Phosphatidylcholines	34-53	gastrin	Homo sapiens	22-29
8431455-6	1993	This may result from the artificial N-terminal anchorage of the gastrin molecules to the bilayers, but also from the relatively tight packing of the phosphatidylcholine vesicles.	Phosphatidylcholines	149-168	gastrin	Homo sapiens	64-71
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	Phosphatidylcholines	88-107	interleukin 1 beta	Homo sapiens	56-65
8383432-3	1993	Signal transduction involved in this process includes FMLP receptor stimulation of phosphoinositide hydrolysis with formation of inositol 1,4,5-trisphosphate and diacylglycerol and phosphatidylcholine hydrolysis with formation of phosphatidic acid.	Phosphatidylcholines	181-200	formyl peptide receptor 1	Homo sapiens	54-58
8383432-9	1993	generation is associated with marked inhibition of phospholipase D (PLD) activity, with limited hydrolysis of phosphatidylcholine and formation of phosphatidic acid.	Phosphatidylcholines	110-129	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	68-71
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	Phosphatidylcholines	109-111	interleukin 1 beta	Homo sapiens	56-65
8431204-10	1993	Addition of quinacrine was also demonstrated to abolish the IL-1-induced hydrolysis of PC and PE but not PI, indicating that PC and PE are the preferred substrates for PLA2 enzymatic activity in human synovial cells.	Phosphatidylcholines	87-89	phospholipase A2 group IB	Homo sapiens	168-172
8431204-10	1993	Addition of quinacrine was also demonstrated to abolish the IL-1-induced hydrolysis of PC and PE but not PI, indicating that PC and PE are the preferred substrates for PLA2 enzymatic activity in human synovial cells.	Phosphatidylcholines	125-127	phospholipase A2 group IB	Homo sapiens	168-172
8431204-11	1993	CONCLUSION: Our findings strongly suggest that AA and PGE2 production by IL-1-triggered synoviocytes are largely dependent upon PLA2-mediated hydrolysis of PC and PE and to a lesser extent upon the earlier degradation of PI.	Phosphatidylcholines	156-158	phospholipase A2 group IB	Homo sapiens	128-132
8431960-9	1993	As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid.	Phosphatidylcholines	37-56	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	62-66
8382052-9	1993	These results demonstrate the kinetic mechanism of in vitro catalysis and suggest a regulatory role for CDP-choline concentration in the diacylglycerol species selectivity of cholinephosphotransferase resulting in the de novo biosynthesis of different molecular species of phosphatidylcholine.	Phosphatidylcholines	273-292	cut-like homeobox 1	Mus musculus	104-107
8431960-9	1993	As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid.	Phosphatidylcholines	37-56	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	106-110
8431960-9	1993	As a result of impaired synthesis of phosphatidylcholine, the INO1-deregulation phenotype is abolished in cho2 mutants transformed with the OPI3 gene on a high copy number plasmid.	Phosphatidylcholines	37-56	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	140-144
8386398-4	1993	Addition of phospholipid vesicles or treatment with phospholipase C inhibited annexin V binding to platelets, suggesting that phospholipid is the binding site for annexin V and that phosphatidylcholine forms at least part of this site.	Phosphatidylcholines	182-201	annexin A5	Homo sapiens	78-87
8381848-9	1993	We suggest that the impairment of phospholipase D-mediated metabolism of phosphatidylcholine in response to fMLP stimulation of polycythemia vera granulocytes may be of significance for the reduced superoxide anion formation induced by fMLP in those cells.	Phosphatidylcholines	73-92	formyl peptide receptor 1	Homo sapiens	108-112
8381848-9	1993	We suggest that the impairment of phospholipase D-mediated metabolism of phosphatidylcholine in response to fMLP stimulation of polycythemia vera granulocytes may be of significance for the reduced superoxide anion formation induced by fMLP in those cells.	Phosphatidylcholines	73-92	formyl peptide receptor 1	Homo sapiens	236-240
8423794-3	1993	In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC.	Phosphatidylcholines	121-140	insulin S homeolog	Xenopus laevis	279-286
8423794-3	1993	In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC.	Phosphatidylcholines	121-140	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	291-294
8423794-3	1993	In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC.	Phosphatidylcholines	121-140	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	81-84
8423794-3	1993	In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC.	Phosphatidylcholines	121-140	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 S homeolog	Xenopus laevis	167-177
8423794-3	1993	In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC.	Phosphatidylcholines	121-140	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 S homeolog	Xenopus laevis	253-263
8420989-11	1993	When liposomes included a moderate quantity of GM3 (0.22-0.44 micrograms (0.2-0.4 nmol)/55 micrograms of phosphatidylcholine, 33 micrograms of cholesterol, 5 micrograms of alpha 5 beta 1 in liposome), adhesion was enhanced significantly.	Phosphatidylcholines	105-124	granulocyte macrophage antigen 3	Mus musculus	47-50
8381273-2	1993	U-PA and ATF stimulated the formation of diacylglycerol (DAG) independently of inositol lipid and phosphatidylcholine turnover, but concomitantly with de novo synthesis from glucose, thus resembling the DAG neosynthesis activated by insulin.	Phosphatidylcholines	98-117	plasminogen activator, urokinase	Homo sapiens	0-4
8422369-1	1993	Phospholipase A2-catalyzed hydrolysis of phosphatidylcholine large unilamellar vesicles is characterized by a period of slow hydrolysis followed by a rapid increase in the rate of hydrolysis.	Phosphatidylcholines	41-60	phospholipase A2 group IB	Homo sapiens	0-16
8418887-4	1993	A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol.	Phosphatidylcholines	130-149	cut-like homeobox 1	Rattus norvegicus	64-67
8418887-4	1993	A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol.	Phosphatidylcholines	277-296	cut-like homeobox 1	Rattus norvegicus	64-67
8418887-6	1993	These results suggest that CDP choline may be a key regulator of the diacylglycerol branchpoint, since diacylglycerol is primarily incorporated into phosphatidylcholine or triacylglycerol depending on whether CDP choline is or is not available.	Phosphatidylcholines	149-168	cut-like homeobox 1	Rattus norvegicus	27-30
8417975-1	1993	An effect of annexin IV and VI on the fluidity of phosphatidylserine/phosphatidylcholine (PS/PC) membranes was studied by spin labeling technique with the use of 5-doxylstearic acid.	Phosphatidylcholines	69-88	surfactant protein C	Homo sapiens	90-95
8318606-3	1993	A deoxycholate extract of a platelet membrane fraction, with a minimum of 15 proteins including GPIb, GPIIb-IIIa and GPIV/III, was incorporated into sphingomyelin: phosphatidylcholine: monosialylganglioside or egg phosphatide small unilamellar vesicles by reverse-phase/sonication and French press extrusion.	Phosphatidylcholines	164-183	CD36 molecule	Rattus norvegicus	117-121
8274032-3	1993	The isolated fractions of phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidyl-ethanolamine (PE) were treated with phospholipase A2 to release fatty acids in the sn-2 position.	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	131-147
8380986-5	1993	PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed.	Phosphatidylcholines	0-6	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-31
8380986-5	1993	PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed.	Phosphatidylcholines	0-6	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-36
8424671-1	1993	This contrasts with phosphatidylcholine/phosphatidylserine mixtures which affect the activity of PKC in a manner independent of the fatty acid composition of the phosphatidylcholine.	Phosphatidylcholines	20-39	proline rich transmembrane protein 2	Homo sapiens	97-100
8424671-1	1993	This contrasts with phosphatidylcholine/phosphatidylserine mixtures which affect the activity of PKC in a manner independent of the fatty acid composition of the phosphatidylcholine.	Phosphatidylcholines	162-181	proline rich transmembrane protein 2	Homo sapiens	97-100
8380986-5	1993	PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed.	Phosphatidylcholines	0-6	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	407-410
8445336-0	1993	Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase.	Phosphatidylcholines	64-83	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	134-178
27280993-0	1993	Substrate Specificity of Rat Plasma Lecithin-cholesterol Acyltransferase towards a Molecular Species of Phosphatidylcholine.	Phosphatidylcholines	104-123	lecithin cholesterol acyltransferase	Rattus norvegicus	36-72
27280993-1	1993	The substrate specificity and the affinity of rat purified lecithin-cholesterol acyltransferase towards the molecular species of phosphatidylcholine (PC) were studied in comparison with the human enzyme.	Phosphatidylcholines	129-148	lecithin cholesterol acyltransferase	Rattus norvegicus	59-95
27280993-1	1993	The substrate specificity and the affinity of rat purified lecithin-cholesterol acyltransferase towards the molecular species of phosphatidylcholine (PC) were studied in comparison with the human enzyme.	Phosphatidylcholines	150-152	lecithin cholesterol acyltransferase	Rattus norvegicus	59-95
8432440-8	1993	Phosphatidyl choline species composed of various acyl fatty acids in the sn-1 and sn-2 positions were used as the sole phospholipid in otherwise identical model bile solutions.	Phosphatidylcholines	0-20	solute carrier family 38 member 3	Homo sapiens	73-77
8432440-8	1993	Phosphatidyl choline species composed of various acyl fatty acids in the sn-1 and sn-2 positions were used as the sole phospholipid in otherwise identical model bile solutions.	Phosphatidylcholines	0-20	solute carrier family 38 member 5	Homo sapiens	82-86
8388315-1	1993	The phosphatidylcholine precursor, cytidine-diphosphocholine (CDP-choline), was injected intraperitoneally (IP) at the dose of 10 or 20 mg/kg/day for 20 days to 24-month-old male rats of the Sprague-Dawley strain that showed cognitive and motor deficits.	Phosphatidylcholines	4-23	cut-like homeobox 1	Rattus norvegicus	62-65
8336521-3	1993	In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered.	Phosphatidylcholines	128-147	C-reactive protein	Homo sapiens	221-224
8412488-2	1993	A high entrapment of calcitonin (CT) was obtained when the vesicles were prepared by sonication and were composed of egg phosphatidylcholine, cholesterol and stearylamine.	Phosphatidylcholines	121-140	calcitonin-related polypeptide alpha	Rattus norvegicus	21-31
8336521-2	1993	Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine.	Phosphatidylcholines	98-117	C-reactive protein	Homo sapiens	29-32
8336521-2	1993	Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine.	Phosphatidylcholines	211-230	C-reactive protein	Homo sapiens	29-32
1447171-6	1992	Lifetime distribution centers for labeled lipids were very similar except for DPH-PC in Lp(a) which was shifted to longer lifetimes, suggesting a less polar environment of PC in Lp(a) than in LDL.	Phosphatidylcholines	82-84	lipoprotein(a)	Homo sapiens	88-93
8336521-3	1993	In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered.	Phosphatidylcholines	34-53	C-reactive protein	Homo sapiens	221-224
1472000-1	1992	Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss &amp; Anderson (1990) J. Biol.	Phosphatidylcholines	172-191	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-99
1472000-1	1992	Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss &amp; Anderson (1990) J. Biol.	Phosphatidylcholines	172-191	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
1472000-1	1992	Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss &amp; Anderson (1990) J. Biol.	Phosphatidylcholines	193-199	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-99
1472000-1	1992	Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss &amp; Anderson (1990) J. Biol.	Phosphatidylcholines	193-199	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
1451798-3	1992	We demonstrate here that membrane cholesterol initiates the activation of phosphatidyl choline phospholipase D and phosphatidic acid thus generated promotes the activation of its phospholipase A2 in the presence of extraplatelet calcium.	Phosphatidylcholines	74-94	phospholipase A2 group IB	Homo sapiens	179-195
1447171-0	1992	Organization of phosphatidylcholine and sphingomyelin in the surface monolayer of low density lipoprotein and lipoprotein(a) as determined by time-resolved fluorometry.	Phosphatidylcholines	16-35	lipoprotein(a)	Homo sapiens	110-124
1333282-4	1992	The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems.	Phosphatidylcholines	120-139	cut-like homeobox 1	Rattus norvegicus	38-41
1333282-4	1992	The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems.	Phosphatidylcholines	120-139	cut-like homeobox 1	Rattus norvegicus	54-57
1463444-0	1992	A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung.	Phosphatidylcholines	65-84	phospholipase A2 group IB	Rattus norvegicus	27-43
1444461-9	1992	The three alpha-class GSTs of lung expressed glutathione peroxidase activities toward the hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, with Km values in the range of 22 to 87 microM and Vmax values in the range of 67-120 mol/mol/min, indicating the involvement of the alpha-class GSTs in the protection mechanisms against peroxidation.	Phosphatidylcholines	108-127	glutathione S-transferase kappa 1	Homo sapiens	22-26
1444461-9	1992	The three alpha-class GSTs of lung expressed glutathione peroxidase activities toward the hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, with Km values in the range of 22 to 87 microM and Vmax values in the range of 67-120 mol/mol/min, indicating the involvement of the alpha-class GSTs in the protection mechanisms against peroxidation.	Phosphatidylcholines	108-127	glutathione S-transferase kappa 1	Homo sapiens	326-330
1334462-2	1992	Previous studies have demonstrated that M-CSF stimulation is associated with phosphatidylcholine (PC) hydrolysis and increased formation of both diacylglycerol (DAG) and phosphorylcholine.	Phosphatidylcholines	98-100	colony stimulating factor 1	Homo sapiens	40-45
1334462-0	1992	Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.	Phosphatidylcholines	47-66	colony stimulating factor 1	Homo sapiens	0-36
1332854-3	1992	Anti-P450RAP immunoblots a protein present in ovarian and testicular microsomes that is the same size as P450RAP and which coelutes with the P450 fraction during chromatography on an immobilized artificial membrane column made with phosphatidylcholine.	Phosphatidylcholines	232-251	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	5-12
1332854-3	1992	Anti-P450RAP immunoblots a protein present in ovarian and testicular microsomes that is the same size as P450RAP and which coelutes with the P450 fraction during chromatography on an immobilized artificial membrane column made with phosphatidylcholine.	Phosphatidylcholines	232-251	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	105-112
1334462-0	1992	Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.	Phosphatidylcholines	47-66	phospholipase A2 group IB	Homo sapiens	93-109
1334462-4	1992	The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity.	Phosphatidylcholines	36-38	colony stimulating factor 1	Homo sapiens	124-129
1334462-2	1992	Previous studies have demonstrated that M-CSF stimulation is associated with phosphatidylcholine (PC) hydrolysis and increased formation of both diacylglycerol (DAG) and phosphorylcholine.	Phosphatidylcholines	77-96	colony stimulating factor 1	Homo sapiens	40-45
1334462-4	1992	The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity.	Phosphatidylcholines	36-38	phospholipase A2 group IVA	Homo sapiens	143-171
1334462-4	1992	The finding that this hydrolysis of PC is associated with increases in production of lysophosphatidylcholine indicates that M-CSF stimulates a cytoplasmic phospholipase A2 (cPLA2) activity.	Phosphatidylcholines	36-38	phospholipase A2 group IVA	Homo sapiens	173-178
1330325-0	1992	TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.	Phosphatidylcholines	28-47	tumor necrosis factor	Homo sapiens	0-3
1459142-8	1992	Phospholipase A2 also stimulated PtdEtOH and diacylglycerol formation from exogenous PtdCho.	Phosphatidylcholines	85-91	phospholipase A2 group IB	Rattus norvegicus	0-16
1431912-2	1992	Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD.	Phosphatidylcholines	72-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	95-110
1431912-2	1992	Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD.	Phosphatidylcholines	72-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	112-115
1333428-8	1992	The acid secretagogues histamine, gastrin, and carbamylcholine stimulated mucin synthesis and PC release.	Phosphatidylcholines	94-96	gastrin	Canis lupus familiaris	34-41
1447319-10	1992	Analysis of the CDP-choline pathway of PC synthesis indicated that the regulatory enzyme, CTP:phosphorylcholine cytidylyltransferase, was stimulated about twofold by PDBu in cells having normal membrane, but not in PE-deficient cells.	Phosphatidylcholines	39-41	cut-like homeobox 1	Rattus norvegicus	16-19
1479295-0	1992	Continuous fluorescence assay for lecithin:cholesterol acyltransferase using a water-soluble phosphatidylcholine.	Phosphatidylcholines	93-112	lecithin-cholesterol acyltransferase	Homo sapiens	34-70
1479295-1	1992	A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution.	Phosphatidylcholines	28-47	lecithin-cholesterol acyltransferase	Homo sapiens	180-216
1479295-1	1992	A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution.	Phosphatidylcholines	28-47	lecithin-cholesterol acyltransferase	Homo sapiens	218-222
1479295-3	1992	In contrast to the reaction of LCAT with aggregated phosphatidylcholines, the reaction of DPybPC with LCAT was not significantly affected by anions, ionic strength, nor apolipoproteins, indicating that these are only effectors of the interfacial reaction.	Phosphatidylcholines	52-72	lecithin-cholesterol acyltransferase	Homo sapiens	31-35
1330325-0	1992	TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.	Phosphatidylcholines	28-47	nuclear factor kappa B subunit 1	Homo sapiens	14-24
1429710-2	1992	The binding of human recombinant factor VIIa to recombinant human TF incorporated into vesicles containing phosphatidylcholine (TF/PC) or phosphatidylcholine/phosphatidylserine (TF/PCPS) was studied using the increased rate of H-D-phenylalanyl L-pipecoyl L-arginine p-nitroanilide (S2238) hydrolysis as a signal for the interaction.	Phosphatidylcholines	107-126	coagulation factor III, tissue factor	Homo sapiens	66-68
1446736-3	1992	Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.	Phosphatidylcholines	198-217	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	185-188
1429710-2	1992	The binding of human recombinant factor VIIa to recombinant human TF incorporated into vesicles containing phosphatidylcholine (TF/PC) or phosphatidylcholine/phosphatidylserine (TF/PCPS) was studied using the increased rate of H-D-phenylalanyl L-pipecoyl L-arginine p-nitroanilide (S2238) hydrolysis as a signal for the interaction.	Phosphatidylcholines	138-157	coagulation factor III, tissue factor	Homo sapiens	66-68
1464752-8	1992	Although hepatic lipase hydrolyzes both triglycerides and phosphatidylcholines, elimination of the triolein from rHDL had no effect on the uptake of rHDL cholesteryl oleate, but replacement of the rHDL phosphatidylcholine with a nonhydrolyzable phosphatidylcholine diether resulted in an 87% reduction in cholesteryl oleate uptake.	Phosphatidylcholines	58-78	lipase C, hepatic type	Rattus norvegicus	9-23
1331066-0	1992	Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors.	Phosphatidylcholines	15-34	coagulation factor II, thrombin	Homo sapiens	48-56
1369037-0	1992	Biomimetic metal-sorbing vesicles: Cd2+ uptake by phosphatidylcholine vesicles doped with ionophore A23187.	Phosphatidylcholines	50-69	CD2 molecule	Homo sapiens	35-38
1369037-1	1992	Unilamellar phosphatidylcholine vesicles, harboring the ionophore, A23187, in the bilayer and the water-soluble chelating agent, nitrilotriacetate, in the vesicle interior, rapidly sequester and concentrate Cd2+ from dilute aqueous solution.	Phosphatidylcholines	12-31	CD2 molecule	Homo sapiens	207-210
1331121-7	1992	PAF also stimulated PGE2 as well as 3H-arachidonic acid and 3H-lyso phosphatidylcholine (PtdCho) formation.	Phosphatidylcholines	89-95	PCNA clamp associated factor	Rattus norvegicus	0-3
1331121-8	1992	We suggest that arachidonate released specifically from PtdCho via phospholipase A2 is a source of this PAF-elevated PGE2.	Phosphatidylcholines	56-62	phospholipase A2 group IB	Rattus norvegicus	67-83
1331121-8	1992	We suggest that arachidonate released specifically from PtdCho via phospholipase A2 is a source of this PAF-elevated PGE2.	Phosphatidylcholines	56-62	PCNA clamp associated factor	Rattus norvegicus	104-107
1464752-8	1992	Although hepatic lipase hydrolyzes both triglycerides and phosphatidylcholines, elimination of the triolein from rHDL had no effect on the uptake of rHDL cholesteryl oleate, but replacement of the rHDL phosphatidylcholine with a nonhydrolyzable phosphatidylcholine diether resulted in an 87% reduction in cholesteryl oleate uptake.	Phosphatidylcholines	58-77	lipase C, hepatic type	Rattus norvegicus	9-23
1390857-3	1992	Using the temperature-sensitive mutant strain Saccharomyces cerevisiae sec 14, which is defective in the phosphatidylinositol transfer protein, it could be demonstrated that this protein is not involved in the transport of phosphatidylinositol and phosphatidylcholine from internal membranes to the plasma membrane.	Phosphatidylcholines	248-267	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	71-77
1400459-2	1992	We report here that immune complexes activate a phosphatidylcholine-specific phospholipase A in a neutrophil only after the cytoplasmic Ca2+ transient has been initiated in the same cell, while chemotactic peptide activation does not proceed via such a phospholipase A-mediated mechanism.	Phosphatidylcholines	48-67	phospholipase A and acyltransferase 1	Homo sapiens	77-92
1400459-2	1992	We report here that immune complexes activate a phosphatidylcholine-specific phospholipase A in a neutrophil only after the cytoplasmic Ca2+ transient has been initiated in the same cell, while chemotactic peptide activation does not proceed via such a phospholipase A-mediated mechanism.	Phosphatidylcholines	48-67	phospholipase A and acyltransferase 1	Homo sapiens	253-268
1400459-3	1992	Measurements of [Ca2+] changes and of phosphatidylcholine-specific phospholipase A activity were made by flow cytometry, using Indo-1 for Ca2+ indication, and a new fluorescent probe, bis-BODIPY-phosphatidylcholine, localized in the inner leaflet of the plasma membrane, to measure phospholipase A activation.	Phosphatidylcholines	38-57	phospholipase A and acyltransferase 1	Homo sapiens	67-82
1390776-12	1992	The phosphorylated annexin I also bound to 20% phosphatidylserine/80% phosphatidylcholine vesicles at lower Ca2+ levels than the native form.	Phosphatidylcholines	70-89	annexin A1	Bos taurus	19-28
1417822-0	1992	Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells.	Phosphatidylcholines	30-49	angiotensinogen	Homo sapiens	53-67
1417792-0	1992	Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst.	Phosphatidylcholines	131-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-32
1289236-6	1992	The presence of phosphatidylcholine and phosphatidylethanolamine in the culture medium also increased the secretion of apoB into the medium.	Phosphatidylcholines	16-35	apolipoprotein B	Rattus norvegicus	119-123
1431573-7	1992	These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions.	Phosphatidylcholines	47-49	solute carrier family 38 member 3	Homo sapiens	114-118
1431573-7	1992	These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions.	Phosphatidylcholines	47-49	solute carrier family 38 member 3	Homo sapiens	175-179
1431573-7	1992	These results suggest that the partitioning of PC species between micelles and vesicles is strictly determined by sn-1 chain length and the degree of unsaturation at both the sn-1 and sn-2 positions.	Phosphatidylcholines	47-49	solute carrier family 38 member 5	Homo sapiens	184-188
1390880-6	1992	These results show that the positional specificity of human plasma LCAT is altered in the presence of sn-2-arachidonoyl PC, or sn-2-docosahexaenoyl PC, probably due to steric restrictions at the active site, and this may account for the formation of disproportionately high concentrations of saturated CE, and low concentrations of long-chain polyunsaturated CE in human plasma, relative to the composition of sn-2-acyl groups in plasma PC.	Phosphatidylcholines	120-122	lecithin-cholesterol acyltransferase	Homo sapiens	67-71
1418772-6	1992	Apolipoprotein A-I has been used as an example of a probe to estimate the effective surface pressure in approximately 1000 A diameter egg yolk phosphatidylcholine/cholesterol/triolein emulsion particles.	Phosphatidylcholines	143-162	apolipoprotein A1	Homo sapiens	0-18
1330154-8	1992	The onset of vasopressin-stimulated inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) mass formation preceded [3H]-PtdBuOH accumulation indicating that PtdCh hydrolysis was activated subsequent to PtdIns(4,5)P2 breakdown.	Phosphatidylcholines	146-151	arginine vasopressin	Homo sapiens	13-24
1526278-8	1992	In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	80-99	interferon gamma	Homo sapiens	219-228
1526278-8	1992	In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	80-99	phospholipase A2 group IB	Homo sapiens	282-298
1526278-8	1992	In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	259-278	interferon gamma	Homo sapiens	125-134
1526278-8	1992	In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	259-278	interferon gamma	Homo sapiens	219-228
1387643-4	1992	Half-maximal inhibition of prothrombinase on and binding of annexin V to small vesicles, composed of 20% phosphatidylserine and 80% phosphatidylcholine, requires 2-3 mM calcium.	Phosphatidylcholines	132-151	annexin A5	Homo sapiens	60-69
1497353-3	1992	Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM.	Phosphatidylcholines	31-50	heparan sulfate proteoglycan 2	Homo sapiens	125-128
1497353-3	1992	Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM.	Phosphatidylcholines	52-54	heparan sulfate proteoglycan 2	Homo sapiens	125-128
1526278-8	1992	In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	80-99	interferon gamma	Homo sapiens	125-134
1390642-3	1992	Analysis of the intramolecular pyrene-pyrene collision data obtained for 30 such species in terms of a simple geometrical model showed that the sn-1 acyl chain penetrates, on the average, 0.84 +/- 0.11 methylene units (0.8 A) deeper into the bilayer than the sn-2 chain at 22 degrees C. A similar value was obtained at 37 degrees C. Since the penetration difference of the sn-1 and sn-2 acyl chains is inherently coupled to the conformation of the glycerol moiety, these data mean that the glycerol moiety of phosphatidylcholine is, on the average, only moderately tilted with respect to the bilayer plane in the liquid-crystalline state.	Phosphatidylcholines	509-528	solute carrier family 38 member 3	Homo sapiens	144-148
1333103-1	1992	Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG).	Phosphatidylcholines	88-107	HDL3	Homo sapiens	73-77
1402396-12	1992	Hydrolysis of phosphatidylcholine by hepatic lipase was threefold higher in A-II-containing HDL2 when compared with HDL2 devoid of apoA-II.	Phosphatidylcholines	14-33	lipase C, hepatic type	Homo sapiens	37-51
1402396-12	1992	Hydrolysis of phosphatidylcholine by hepatic lipase was threefold higher in A-II-containing HDL2 when compared with HDL2 devoid of apoA-II.	Phosphatidylcholines	14-33	apolipoprotein A2	Homo sapiens	131-138
1508183-1	1992	A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras.	Phosphatidylcholines	95-114	heparan sulfate proteoglycan 2 L homeolog	Xenopus laevis	119-122
1333103-1	1992	Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG).	Phosphatidylcholines	109-111	HDL3	Homo sapiens	73-77
1333103-2	1992	In (3H) PC prelabelled platelets, phosphocholine is released into the medium during HDL3 induced PC turnover with a 1.5 to 2 fold increment, indicating that HDL3 stimulated DAG generation in platelets is likely due to phospholipase C (PLC).	Phosphatidylcholines	8-10	HDL3	Homo sapiens	157-161
1512242-5	1992	By using the MIANS moiety as a fluorescent reporter group, we were able to monitor directly the binding of the MIANS-beta gamma T complex to light-activated rhodopsin, which was reconstituted into phosphatidylcholine vesicles, through an enhancement (30-50%) in the MIANS fluorescence.	Phosphatidylcholines	197-216	rhodopsin	Homo sapiens	157-166
1504094-0	1992	Promotion of beta-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine.	Phosphatidylcholines	92-111	islet amyloid polypeptide	Homo sapiens	79-85
1510717-0	1992	In human monocytes interleukin-1 stimulates a phospholipase C active on phosphatidylcholine and inactive on phosphatidylinositol.	Phosphatidylcholines	72-91	interleukin 1 alpha	Homo sapiens	19-32
1387325-1	1992	The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated.	Phosphatidylcholines	157-176	annexin A2	Bos taurus	87-97
1387325-1	1992	The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated.	Phosphatidylcholines	157-176	LOC104974671	Bos taurus	121-137
1387325-1	1992	The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated.	Phosphatidylcholines	157-176	LOC104974671	Bos taurus	139-143
1387325-1	1992	The effects of human recombinant lipocortin I (annexin I) and bovine lung calpactin I (annexin II) on porcine pancreatic phospholipase A2 (PLA2) activity in phosphatidylcholine (PC)/deoxycholate (DOC) mixtures were investigated.	Phosphatidylcholines	178-180	LOC104974671	Bos taurus	139-143
1512228-10	1992	From these data, we conclude that MDCK cells contain two PLD subtypes: 1) a membrane-associated, PC-selective enzyme that responds to TPA resulting in prolonged hydrolysis of PC (the PC-PLD is Ca(2+)-independent, but requires detergent); 2) a cytosolic, PI-selective enzyme that responds rapidly but transiently to bradykinin (the PI-PLD requires Ca2+ but not detergent).	Phosphatidylcholines	97-99	kininogen 1	Canis lupus familiaris	315-325
1510717-3	1992	Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC.	Phosphatidylcholines	95-114	phospholipase A2 group IB	Homo sapiens	46-62
1387325-5	1992	Despite a large excess of detergent, precipitates were, at times, observed upon incubation of some PC/DOC mixtures at 37 degrees C. Such behavior is of interest in view of the numerous reports of PLA2 inhibition by annexins and annexin-derived peptides in the PC/DOC system.	Phosphatidylcholines	99-101	phospholipase A2 group IB	Homo sapiens	196-200
1510717-3	1992	Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC.	Phosphatidylcholines	95-114	phospholipase A2 group IB	Homo sapiens	64-68
1387686-1	1992	Low-angle neutron solution scattering has been used to study the structure of annexin-V and its interaction with small single-bilayer vesicles consisting of phosphatidylserine and phosphatidylcholine at a 33:66 (mol:mol) ratio.	Phosphatidylcholines	180-199	annexin A5	Homo sapiens	78-87
1510717-3	1992	Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC.	Phosphatidylcholines	116-118	phospholipase A2 group IB	Homo sapiens	46-62
1510717-3	1992	Cell stimulation results in the activation of phospholipase A2 (PLA2) whose major substrate is phosphatidylcholine (PC) and the release of the eicosanoid precursor arachidonic acid (AA) from PC.	Phosphatidylcholines	116-118	phospholipase A2 group IB	Homo sapiens	64-68
1510717-9	1992	In contrast, in cells labeled with [3H]AA, IL-1 causes the formation of DAG associated with the hydrolysis of PC.	Phosphatidylcholines	110-112	interleukin 1 alpha	Homo sapiens	43-47
1500722-5	1992	However, prolonged incubation with human rIL-1 beta (30 to 180 min) inhibited in a concentration- and time-dependent manner the release of AA and the hydrolysis of phosphatidylcholine in ionophore-stimulated eosinophils.	Phosphatidylcholines	164-183	interleukin 1 beta	Rattus norvegicus	41-51
1323272-0	1992	Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells.	Phosphatidylcholines	90-109	arginine vasopressin	Homo sapiens	25-36
1324124-4	1992	Superoxide formation was evidenced by SOD-inhibitable cytochrome c reduction in the reaction of NTP with egg phosphatidylcholine at molar ratio 1:1, and 1:3.	Phosphatidylcholines	109-128	superoxide dismutase 1	Homo sapiens	38-41
1324124-4	1992	Superoxide formation was evidenced by SOD-inhibitable cytochrome c reduction in the reaction of NTP with egg phosphatidylcholine at molar ratio 1:1, and 1:3.	Phosphatidylcholines	109-128	cytochrome c, somatic	Homo sapiens	54-66
1323272-1	1992	The kinetics of vasopressin-stimulated PtdIns(4,5)P2 and phosphatidylcholine (PtdCho) hydrolysis in relation to sustained diacylglycerol (DAG) formation was investigated in A10 vascular-smooth-muscle cells in culture.	Phosphatidylcholines	57-76	arginine vasopressin	Homo sapiens	16-27
1323272-1	1992	The kinetics of vasopressin-stimulated PtdIns(4,5)P2 and phosphatidylcholine (PtdCho) hydrolysis in relation to sustained diacylglycerol (DAG) formation was investigated in A10 vascular-smooth-muscle cells in culture.	Phosphatidylcholines	78-84	arginine vasopressin	Homo sapiens	16-27
1323272-7	1992	Vasopressin stimulated an increase in formation of choline, but not of phosphocholine, suggesting that PLD was the major catalytic route of PtdCho hydrolysis in this cell line.	Phosphatidylcholines	140-146	arginine vasopressin	Homo sapiens	0-11
1323272-7	1992	Vasopressin stimulated an increase in formation of choline, but not of phosphocholine, suggesting that PLD was the major catalytic route of PtdCho hydrolysis in this cell line.	Phosphatidylcholines	140-146	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
1643097-0	1992	Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	104-123	LOC104974671	Bos taurus	17-33
1643097-8	1992	There was a clear preference for PC peroxidation for all vesicle compositions tested and PC was preferentially hydrolyzed by PLA2.	Phosphatidylcholines	89-91	LOC104974671	Bos taurus	125-129
1631141-7	1992	The results suggest that cis-unsaturated fatty acids, which are presumably produced from phosphatidylcholine by signal-dependent activation of phospholipase A2, may take part directly in cell signaling through the protein kinase C pathway.	Phosphatidylcholines	89-108	phospholipase A2 group IB	Homo sapiens	143-159
1637948-0	1992	Platelet-activating factor mediates phosphatidylcholine hydrolysis by phospholipase D in human endometrium.	Phosphatidylcholines	36-55	PCNA clamp associated factor	Homo sapiens	0-26
1627547-0	1992	Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase A2.	Phosphatidylcholines	102-122	phospholipase A2 group IB	Homo sapiens	126-142
1637307-0	1992	Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis.	Phosphatidylcholines	103-122	epidermal growth factor	Mus musculus	0-23
1627557-5	1992	We show that when the PI is sufficiently dispersed by dilution with PC, it inhibits microtubule assembly by binding to MAP2 with an apparent stoichiometry, after correction for the bilamellar nature of the liposomes, of 1:1 mol.mol-1 PI:MAP2.	Phosphatidylcholines	68-70	microtubule associated protein 2	Homo sapiens	119-123
1637948-9	1992	It is proposed that PAF induces PC hydrolysis as a consequence of an early phospholipase D-catalyzed breakdown of PC in human secretory endometrium.	Phosphatidylcholines	32-34	PCNA clamp associated factor	Homo sapiens	20-23
1637948-2	1992	The mechanism of phosphatidylcholine (PC) degradation stimulated by PAF was investigated in endometrial explants prelabeled with [methyl-3H]choline or preincubated with [3H]butan-1-ol.	Phosphatidylcholines	17-36	PCNA clamp associated factor	Homo sapiens	68-71
1637948-2	1992	The mechanism of phosphatidylcholine (PC) degradation stimulated by PAF was investigated in endometrial explants prelabeled with [methyl-3H]choline or preincubated with [3H]butan-1-ol.	Phosphatidylcholines	38-40	PCNA clamp associated factor	Homo sapiens	68-71
1377491-0	1992	Binding of substance P to monolayers and vesicles made of phosphatidylcholine and/or phosphatidylserine.	Phosphatidylcholines	58-77	tachykinin precursor 1	Homo sapiens	11-22
1322489-7	1992	Digestion of control heart sarcolemma with phospholipase A2 inhibited Ca2+ transport and the inhibition was reversible by phosphatidylcholine.	Phosphatidylcholines	122-141	phospholipase A2 group IB	Canis lupus familiaris	43-59
1419482-2	1992	At 1 U/ml, phosphatidylcholine-specific phospholipase C increases DAG, alters intracellular pH and inhibits the induction of meiosis by insulin or progesterone.	Phosphatidylcholines	11-30	insulin S homeolog	Xenopus laevis	136-143
1377491-3	1992	Injection of SP into the aqueous subphase led to an expansion of phosphatidylcholine (PtdCho) or phosphatidylserine (PtdSer) monolayer surface area.	Phosphatidylcholines	65-84	tachykinin precursor 1	Homo sapiens	13-15
1377491-3	1992	Injection of SP into the aqueous subphase led to an expansion of phosphatidylcholine (PtdCho) or phosphatidylserine (PtdSer) monolayer surface area.	Phosphatidylcholines	86-92	tachykinin precursor 1	Homo sapiens	13-15
1577735-3	1992	We therefore used a surface balance and surface radioactivity detector to investigate the adsorption of apoA-IV to egg phosphatidylcholine monolayers spread at the air/water interface.	Phosphatidylcholines	119-138	apolipoprotein A4	Homo sapiens	104-111
1434119-1	1992	Recombinant human tumor necrosis factor-beta (rhTNF-beta) may be encapsulated with high efficiency in phosphatidylcholine and distearoylphosphatidylcholine liposomes, with entrapment values of 93.4% and 92.3%, respectively, by first entrapping the substance in multilamellar vesicles using a high solute-to-phospholipid ratio followed by freeze-drying and then rehydration.	Phosphatidylcholines	102-121	lymphotoxin alpha	Homo sapiens	18-44
1315771-0	1992	Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression.	Phosphatidylcholines	48-67	protein kinase C, beta	Rattus norvegicus	82-105
1387413-0	1992	Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position.	Phosphatidylcholines	73-92	lecithin-cholesterol acyltransferase	Homo sapiens	14-50
1387413-6	1992	The purpose of the present study was to directly test the influence of eicosapentaenoic acid (20:5 n-3) and docosahexaenoic acid (22:6 n-3) in the sn-2 position of phosphatidylcholine (PC) on the activity of LCAT.	Phosphatidylcholines	164-183	lecithin-cholesterol acyltransferase	Homo sapiens	208-212
1376049-1	1992	About half of the phosphatidylcholine (PtC)-binding peritoneal B cells of B10.H-2aH-4bp/Wts mice express the VH12 gene.	Phosphatidylcholines	39-42	immunoglobulin heavy chain (V12 family)	Mus musculus	109-113
1376049-1	1992	About half of the phosphatidylcholine (PtC)-binding peritoneal B cells of B10.H-2aH-4bp/Wts mice express the VH12 gene.	Phosphatidylcholines	18-37	immunoglobulin heavy chain (V12 family)	Mus musculus	109-113
1596521-3	1992	Phospholipid transfer proteins I and III transferred phosphatidylcholine (PC) and phosphatidylinositol (PI) from donor unilamellar liposomes to acceptor multilamellar liposomes; protein II transferred PC but not PI.	Phosphatidylcholines	53-72	annexin A4	Homo sapiens	178-188
1376071-0	1992	Characterization of expanded populations of peritoneal CD5 B cells specific for phosphatidyl choline in old B10.H-2aH-4bp/Wts mice.	Phosphatidylcholines	80-100	CD5 antigen	Mus musculus	55-58
1320459-2	1992	During the period of induction, both insulin and progesterone induced an increase in 32PO4 labeling of phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	103-122	insulin S homeolog	Xenopus laevis	37-44
1566749-3	1992	Since PAF-AH is also known to hydrolyze oxidized derivatives of phosphatidylcholine and since RBCs are not effector cells of PAF, the observed activity in RBC membranes may play a potential role in degrading oxidation products of membrane phospholipids.	Phosphatidylcholines	64-83	phospholipase A2 group VII	Homo sapiens	6-12
1590762-5	1992	The synthesis of phosphatidylcholine was dependent on addition of CDP-choline.	Phosphatidylcholines	17-36	cut-like homeobox 1	Rattus norvegicus	66-69
1421279-3	1992	Specific activity of control phosphatidylcholine was about 15-fold higher than that of phosphatidylcholine from tert-butyl hydroperoxide-treated cells.	Phosphatidylcholines	87-106	telomerase reverse transcriptase	Mus musculus	112-116
1581336-1	1992	The interactions of salmon calcitonin with glycosphingolipid sulfatide are studied by right angle light scattering from the lipid suspension, by the excimer to monomer ratio (E/M) of the fluorescence intensity of pyrene phosphatidylcholine and pyrene sulfatide and by the leakage of carboxyfluorescein.	Phosphatidylcholines	220-239	calcitonin related polypeptide alpha	Homo sapiens	27-37
1315360-6	1992	Finally, direct measurement of enzymatic activity in vitro using radiolabeled phospholipid vesicles showed that CD69 cross-linking resulted in PLA2-dependent arachidonic acid and lysophosphatidylcholine generation from phosphatidylcholine, which was sensitive to quinacrine but not to R68070.	Phosphatidylcholines	183-202	CD69 molecule	Homo sapiens	112-116
1315360-6	1992	Finally, direct measurement of enzymatic activity in vitro using radiolabeled phospholipid vesicles showed that CD69 cross-linking resulted in PLA2-dependent arachidonic acid and lysophosphatidylcholine generation from phosphatidylcholine, which was sensitive to quinacrine but not to R68070.	Phosphatidylcholines	183-202	phospholipase A2 group IB	Homo sapiens	143-147
1510877-0	1992	v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis.	Phosphatidylcholines	63-82	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	2-5
19431824-6	1992	The bilayer transition temperatures of saturated asymmetrical phosphatidylcholines are interpreted by assuming that the transition enthalpy and transition entropy are linearly related to the absolute value of the difference in chain length between the sn-1 and sn-2 chains, with constant end contributions.	Phosphatidylcholines	62-82	solute carrier family 38 member 3	Homo sapiens	252-265
1323686-6	1992	The 17-amino acid HA2 peptide (HA2.17) destabilized phosphatidylcholine (PC) vesicles even at neutral pH, but the rate and extent of destabilization increased at lower pH.	Phosphatidylcholines	52-71	myosin IG	Homo sapiens	18-21
1323686-6	1992	The 17-amino acid HA2 peptide (HA2.17) destabilized phosphatidylcholine (PC) vesicles even at neutral pH, but the rate and extent of destabilization increased at lower pH.	Phosphatidylcholines	52-71	myosin IG	Homo sapiens	31-34
1533163-1	1992	The selectivity of phospholipase A2 from serum was evaluated using radioassays and mass analyses of fatty acids liberated from phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	127-146	phospholipase A2 group IB	Homo sapiens	19-35
1623574-3	1992	Also a decreased [32P]phosphatidylcholine and an increased [32P]lysophosphatidylcholine labeling were observed, suggesting an increased activity of phosphatidylcholine-specific phospholipase A2.	Phosphatidylcholines	22-41	phospholipase A2 group IB	Rattus norvegicus	177-193
1532578-0	1992	Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.	Phosphatidylcholines	71-90	phospholipase A2, group IB, pancreas	Mus musculus	44-60
1576162-4	1992	In recent years the fluorescent analogue of phosphatidylcholine, C6-NBD-PC, has been used for determination of the activity of soluble and membrane-bound PLA2.	Phosphatidylcholines	44-63	phospholipase A2 group IB	Homo sapiens	154-158
1355578-0	1992	Relationship between translocation of long-chain acyl-CoA hydrolase, phosphatidate phosphohydrolase and CTP:phosphocholine cytidylyltransferase and the synthesis of triglycerides and phosphatidylcholine in rat liver.	Phosphatidylcholines	183-202	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	104-143
1304354-2	1992	Three vitamin K-dependent proteins (factor X, protein Z, and prothrombin) dissociated from small unilamellar vesicles (SUVs, 30 nm diameter) composed of 25% phosphatidylserine (PS) and 75% phosphatidylcholine (PC) at comparable pressures (midpoints of 0.3-0.6 kbar).	Phosphatidylcholines	210-212	coagulation factor II, thrombin	Homo sapiens	36-72
1532578-4	1992	The corresponding production of lysophosphatidylcholine suggested the involvement of a phosphatidylcholine-specific phospholipase A2.	Phosphatidylcholines	36-55	phospholipase A2, group IB, pancreas	Mus musculus	116-132
1532578-6	1992	These data strongly suggest that occupation of the bombesin receptor is closely coupled to activation of phospholipase A2 which results in the rapid release of arachidonic acid from phosphatidylcholine.	Phosphatidylcholines	182-201	phospholipase A2, group IB, pancreas	Mus musculus	105-121
1540589-8	1992	The hydrolysis of HDL-I phosphatidylcholine was approximately 3-fold higher than HDL-II, supporting the hypothesis that HL preferably hydrolyzes the phospholipids in apoE-rich HDL.	Phosphatidylcholines	24-43	apolipoprotein E	Homo sapiens	166-170
1311313-4	1992	Acetylation of bovine fragment 1 in the absence of Ca(II) or Mg(II) ions results in the loss of the metal ion-promoted quenching of the intrinsic Trp fluorescence of the protein and the Ca(II)-mediated binding to phosphatidylserine/phosphatidylcholine (PS/PC) vesicles.	Phosphatidylcholines	232-251	carbonic anhydrase 2	Bos taurus	186-192
1348227-6	1992	In conclusion, both beta 1- and beta 2-adrenoceptor subtypes mediate phosphatidylcholine secretion in rat type II pneumocytes.	Phosphatidylcholines	69-88	adrenoceptor beta 1	Rattus norvegicus	20-51
1537086-4	1992	In sharp contrast, human mitochondrial phospholipase A2 1) accounts for only a diminutive amount of total myocardial phospholipase A2 activity (1-2%), 2) is augmented by calcium ion, 3) exhibits a higher reaction velocity using phosphatidylcholine in comparison with plasmenylcholine substrate, and 4) is not substantially inhibited by either DTNB or bromoenol lactone.	Phosphatidylcholines	228-247	phospholipase A2 group IB	Homo sapiens	39-55
1543719-5	1992	This change in Cdl was sensitive enough to monitor the course of enzymatic hydrolysis of the PC monolayer by PLD.	Phosphatidylcholines	93-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-112
1563569-1	1992	Phospholipase A2 activity (EC 3.1.1.4) was estimated in low-speed supernatants of human placenta by measuring the release of arachidonic acid from phosphatidylcholine, 1-stearoyl-2-[3H]arachidonyl and other phospholipids under alkaline conditions (pH 8).	Phosphatidylcholines	147-166	phospholipase A2 group IB	Homo sapiens	0-16
1311959-9	1992	These findings suggest that the increase in PGI2 release elicited by ATP and UTP is at least partially dependent upon a phospholipase C-mediated increase in [Ca2+]i and the subsequent activation of a phosphatidylcholine-specific phospholipase A2.	Phosphatidylcholines	200-219	LOC104974671	Bos taurus	229-245
1531960-3	1992	The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway.	Phosphatidylcholines	23-42	hepatocyte growth factor	Rattus norvegicus	4-7
1311563-6	1992	Annexin-V induced a decrease of 70% of thrombomodulin activity when thrombomodulin (5.4-214 nM) was reconstituted into phosphatidylcholine/phosphatidylserine (1:1, mol/mol) vesicles at 37.5 or 75 microM-phospholipid concentration, the apparent Ki being 0.5 microM at 75 microM-lipid.	Phosphatidylcholines	119-138	annexin A5	Homo sapiens	0-9
1531960-3	1992	The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway.	Phosphatidylcholines	44-46	hepatocyte growth factor	Rattus norvegicus	4-7
1317973-7	1992	The results suggest that the decreased binding sites of beta-adrenoceptor in lung tissue of rat during hyperthermia may be contributed to the activation of PLA2, which then accelerated the catabolism of phospholipids such as PC and PS in the cell plasma membrane, with a consequent alteration of membrane fluidity.	Phosphatidylcholines	225-227	phospholipase A2 group IB	Rattus norvegicus	156-160
1736998-0	1992	Lateral interactions of pig apolipoprotein A-1 with egg yolk phosphatidylcholine and with cholesterol in mixed monolayers at the triolein-saline interface.	Phosphatidylcholines	61-80	apolipoprotein A1	Sus scrofa	28-46
1569041-1	1992	Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate.	Phosphatidylcholines	171-190	phospholipase A2 group IB	Rattus norvegicus	0-16
1569041-1	1992	Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate.	Phosphatidylcholines	192-194	phospholipase A2 group IB	Rattus norvegicus	0-16
1569706-0	1992	[The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini (II)].	Phosphatidylcholines	45-64	cholecystokinin	Rattus norvegicus	26-41
1569706-1	1992	To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini.	Phosphatidylcholines	97-116	cholecystokinin	Rattus norvegicus	72-87
1569706-1	1992	To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini.	Phosphatidylcholines	97-116	cholecystokinin	Rattus norvegicus	89-92
1736998-6	1992	The large difference in lateral interaction energy with apoA-1 between PC and cholesterol in a mixed monolayer is discussed in connection with current problems in lipoprotein catabolism: reverse cholesterol transport, alterations in affinity of lipid particles to apoA-1, and formation of high-density lipoproteins and abnormal lipoproteins.	Phosphatidylcholines	71-73	apolipoprotein A1	Sus scrofa	56-62
1736998-6	1992	The large difference in lateral interaction energy with apoA-1 between PC and cholesterol in a mixed monolayer is discussed in connection with current problems in lipoprotein catabolism: reverse cholesterol transport, alterations in affinity of lipid particles to apoA-1, and formation of high-density lipoproteins and abnormal lipoproteins.	Phosphatidylcholines	71-73	apolipoprotein A1	Sus scrofa	264-270
1539683-0	1992	Vasopressin and phorbol ester-stimulated phosphatidylcholine metabolism in mesangial cells.	Phosphatidylcholines	41-60	arginine vasopressin	Rattus norvegicus	0-11
1539683-1	1992	We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells.	Phosphatidylcholines	115-134	arginine vasopressin	Rattus norvegicus	95-106
1539683-1	1992	We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells.	Phosphatidylcholines	115-134	arginine vasopressin	Rattus norvegicus	108-110
1539683-2	1992	PMA and VP stimulate the incorporation of [3H]choline into phosphatidylcholine and the release of [3H]choline into the culture medium.	Phosphatidylcholines	59-78	arginine vasopressin	Rattus norvegicus	8-10
1539683-6	1992	A dual labeling study ([3H]myristic acid and [14C]arachidonic acid) suggests that phosphatidylcholine is an important source of diacylglycerol in cells treated with VP and PMA.	Phosphatidylcholines	82-101	arginine vasopressin	Rattus norvegicus	165-167
1623116-7	1992	The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation.	Phosphatidylcholines	46-65	heparan sulfate proteoglycan 2	Homo sapiens	149-152
1623116-7	1992	The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation.	Phosphatidylcholines	46-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
1579054-1	1992	This report examines the distribution of n-3 and n-6 fatty acids in heart, kidney and liver phosphatidylcholine and phosphatidylethanolamine of suckling mice from dams fed a fat-supplemented diet with variable n-3/n-6 ratios.	Phosphatidylcholines	92-111	notch 3	Mus musculus	41-44
1569706-1	1992	To better understand the mechanism underlying the inhibition induced by cholecystokinin (CCK) of phosphatidylcholine (PC) synthesis, the effects of CCK treatment on the activities of enzyme involved in PC synthesis via CDP-choline pathway were studied in isolated rat pancreatic acini.	Phosphatidylcholines	118-120	cholecystokinin	Rattus norvegicus	89-92
1569706-5	1992	This inhibition of PC synthesis induced by CCK was accompanied by a delayed disappearance of [3H] diacylglycerol (DAG), the radioactivity of which was 225% of control at 60 min.	Phosphatidylcholines	19-21	cholecystokinin	Rattus norvegicus	43-46
1569706-7	1992	These results suggest that CCK inhibits PC synthesis by inducing the inhibition of CTP: phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	40-42	cholecystokinin	Rattus norvegicus	27-30
1569706-7	1992	These results suggest that CCK inhibits PC synthesis by inducing the inhibition of CTP: phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	40-42	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	83-123
1569706-8	1992	The inhibition by CCK of PC synthesis may contribute to the sustained accumulation of DAG in pancreatic acinar cells.	Phosphatidylcholines	25-27	cholecystokinin	Rattus norvegicus	18-21
1309795-12	1992	In another approach, the diacylglycerol levels were increased by an inhibitor of diacylglycerol lipase (U-57908) which also reversed the cAMP effects on diacylglycerol levels and phosphatidylcholine biosynthesis.	Phosphatidylcholines	179-198	lipase G, endothelial type	Rattus norvegicus	96-102
1309795-14	1992	Instead, phosphatidylcholine biosynthesis appears to be inhibited due to a decreased level of diacylglycerol, a substrate for CDP-choline: 1,2-diacylglycerol cholinephosphotransferase.	Phosphatidylcholines	9-28	cut-like homeobox 1	Rattus norvegicus	126-129
1730636-4	1992	This effect could be entirely reproduced by incubation with phosphatidylcholine vesicles which increased apoE accumulation in the medium by 2-6-fold.	Phosphatidylcholines	60-79	apolipoprotein E	Homo sapiens	105-109
1541325-2	1992	In contrast, in cells labelled with [3H]myristic acid, a tracer that preferentially marks phosphatidylcholine, angiotensin II induced a delayed monophasic production of 1,2-diacylglycerol.	Phosphatidylcholines	90-109	angiotensinogen	Rattus norvegicus	111-125
1541325-3	1992	This delayed peak of 1,2-diacylglycerol generation was associated with a concomitant increase in choline formation, suggesting that stimulation of mesangial cells with angiotensin II causes a phospholipase D-mediated phosphatidylcholine hydrolysis.	Phosphatidylcholines	217-236	angiotensinogen	Rattus norvegicus	168-182
1541325-7	1992	These data clearly indicate that angiotensin II AT1 receptors trigger phospholipase D-mediated phosphatidylcholine hydrolysis in rat mesangial cells.	Phosphatidylcholines	95-114	angiotensinogen	Rattus norvegicus	33-47
1636497-1	1992	Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates.	Phosphatidylcholines	291-310	phospholipase A2, group IB, pancreas	Mus musculus	0-16
1731954-4	1992	We studied the effects of EGF on the incorporation of glycerol into lamellar body disaturated phosphatidylcholine (DSPC) in sex-specific fetal rabbit lung explants prepared at 21 and 24 days gestation (term 31 days).	Phosphatidylcholines	94-113	pro-epidermal growth factor	Oryctolagus cuniculus	26-29
1323204-11	1992	These data suggest that PKC may act as a switch, terminating inositol phospholipid hydrolysis and activating the hydrolysis of phosphatidylcholine.	Phosphatidylcholines	127-146	proline rich transmembrane protein 2	Homo sapiens	24-27
1636497-1	1992	Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates.	Phosphatidylcholines	312-314	phospholipase A2, group IB, pancreas	Mus musculus	0-16
1727727-1	1992	Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation.	Phosphatidylcholines	103-122	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	132-147
1462844-0	1992	Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts.	Phosphatidylcholines	58-77	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	91-96
1727727-1	1992	Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation.	Phosphatidylcholines	103-122	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	149-152
1727727-8	1992	These findings demonstrate for the first time that a physiological nutrient activates a phospholipase directed against endogenous phosphatidylcholine in intact islet cells; furthermore, they indicate a role for PLD in a delayed formation of phosphatidic acid in the islet cell.	Phosphatidylcholines	130-149	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	211-214
1309592-0	1992	Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.	Phosphatidylcholines	39-58	transforming growth factor beta 1	Homo sapiens	74-107
1299136-3	1992	Phospholipid analysis revealed that 1-O-alkyl-2-acyl-sn-glycerophosphocholine, a stored form of PAF precursor, accounted for 61.4% of the choline glycerophospholipids.	Phosphatidylcholines	138-166	PCNA clamp associated factor	Homo sapiens	96-99
1756867-6	1991	Phosphatidylcholine in mast cell membranes was appreciably hydrolyzed to liberate free arachidonic acid when mast cells were incubated with 14-kDa group II phospholipase A2 added exogenously in the presence of the antigen.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	156-172
1660466-5	1991	Here we show that eluates of antiphosphotyrosine affinity purified lysates of colony-stimulating factor 1-stimulated cells contain elevated levels of phosphatidylcholine-specific phospholipase C activity.	Phosphatidylcholines	150-169	colony stimulating factor 1	Homo sapiens	78-105
1662619-4	1991	Three lines of evidence indicate phospholipase A2 activity to be involved in arachidonic acid release: (a) its inhibition by mepacrine, (b) the concomitant generation of lysophosphatidylcholine from [3H]choline-labeled cells and (c) an increase in arachidonic acid release from 14C-labeled phosphatidylcholine in particulate fractions from PMA-treated and bradykinin-treated keratinocytes.	Phosphatidylcholines	174-193	phospholipase A2, group IB, pancreas	Mus musculus	33-49
1744125-3	1991	Purified betaglycan has properties similar to betaglycan affinity-labeled in intact cells: it binds TGF-beta 1 and TGF-beta 2 with KD approximately 0.2 nM, contains heparan sulfate and chondroitin sulfate glycosaminoglycan (GAG) chains and N-linked glycans attached to a 110-kDa core protein, and can spontaneously associate with phosphatidylcholine liposomes.	Phosphatidylcholines	330-349	transforming growth factor beta receptor 3	Rattus norvegicus	9-19
1787343-6	1991	After TNF stimulation, the level of phosphatidylcholine (PC) decreased.	Phosphatidylcholines	36-55	tumor necrosis factor	Homo sapiens	6-9
1667458-1	1991	We have developed an assay to measure the affinity of serum vitamin D binding protein for 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and vitamin D3, using uniform diameter (6.4 microns) polystyrene beads coated with phosphatidylcholine and vitamin D metabolites as the vitamin D donor.	Phosphatidylcholines	221-240	GC vitamin D binding protein	Homo sapiens	60-85
1667458-4	1991	Phosphatidylcholine/vitamin D metabolite-coated beads (1 microM vitamin D metabolite) were incubated with varying concentrations of serum vitamin D binding protein under conditions in which the bead surfaces were saturated with protein, but most of the protein was free in solution.	Phosphatidylcholines	0-19	GC vitamin D binding protein	Homo sapiens	138-163
1787343-6	1991	After TNF stimulation, the level of phosphatidylcholine (PC) decreased.	Phosphatidylcholines	57-59	tumor necrosis factor	Homo sapiens	6-9
1787343-7	1991	Concomitantly, phospholipase A2 (PLA2) hydrolyzed PC producing a transiently increased level of lysophosphatidylcholine.	Phosphatidylcholines	50-52	phospholipase A2 group IB	Homo sapiens	15-31
1787343-7	1991	Concomitantly, phospholipase A2 (PLA2) hydrolyzed PC producing a transiently increased level of lysophosphatidylcholine.	Phosphatidylcholines	50-52	phospholipase A2 group IB	Homo sapiens	33-37
1796676-3	1991	In the first hour after antigen challenge with 0.5 mg nematode AChE there was a very sharp rise in Ch mainly from agonist-stimulated and phospholipase mediated phosphatidylcholine (PC) breakdown.	Phosphatidylcholines	160-179	acetylcholinesterase	Bos taurus	63-67
1796676-3	1991	In the first hour after antigen challenge with 0.5 mg nematode AChE there was a very sharp rise in Ch mainly from agonist-stimulated and phospholipase mediated phosphatidylcholine (PC) breakdown.	Phosphatidylcholines	181-183	acetylcholinesterase	Bos taurus	63-67
1659906-7	1991	These data are consistent with the hypothesis that PA produced through the hydrolysis of PC by PLD is an important mediator of O2- production in response to receptor-dependent agonists.	Phosphatidylcholines	89-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	95-98
1657994-0	1991	Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini.	Phosphatidylcholines	25-44	cholecystokinin	Rattus norvegicus	0-15
1657994-7	1991	Furthermore, W-7 or W-5, a calmodulin antagonist, reversed the inhibition by CCK8 of PC synthesis, suggesting that a Ca(2+)-calmodulin-dependent pathway may be involved in CCK-induced inhibition of PC synthesis in acini.	Phosphatidylcholines	85-87	cholecystokinin	Rattus norvegicus	77-80
1657994-7	1991	Furthermore, W-7 or W-5, a calmodulin antagonist, reversed the inhibition by CCK8 of PC synthesis, suggesting that a Ca(2+)-calmodulin-dependent pathway may be involved in CCK-induced inhibition of PC synthesis in acini.	Phosphatidylcholines	198-200	cholecystokinin	Rattus norvegicus	77-80
1657994-10	1991	The analysis of enzyme activity involved in PC synthesis via CDP-choline pathway showed that CCK treatment of acini reduced CTP:phosphocholine cytidylyltransferase activity in both cytosolic and particulate fraction, a finding consistent with the delayed disappearance of phosphocholine induced by CCK in pulse-chase study.	Phosphatidylcholines	44-46	cholecystokinin	Rattus norvegicus	93-96
1657994-10	1991	The analysis of enzyme activity involved in PC synthesis via CDP-choline pathway showed that CCK treatment of acini reduced CTP:phosphocholine cytidylyltransferase activity in both cytosolic and particulate fraction, a finding consistent with the delayed disappearance of phosphocholine induced by CCK in pulse-chase study.	Phosphatidylcholines	44-46	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	124-163
1657994-15	1991	This inhibition of PC synthesis induced by CCK was accompanied by a delayed disappearance of [3H]diacylglycerol, the radioactivity of which was 225% of control at 60 min.	Phosphatidylcholines	19-21	cholecystokinin	Rattus norvegicus	43-46
1657994-16	1991	These results indicate that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP:phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	41-43	cholecystokinin	Rattus norvegicus	28-31
1657994-16	1991	These results indicate that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP:phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	41-43	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	136-175
1659906-1	1991	Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils.	Phosphatidylcholines	48-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	76-91
1659906-1	1991	Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils.	Phosphatidylcholines	48-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
1659906-1	1991	Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils.	Phosphatidylcholines	69-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	76-91
1655413-0	1991	Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis.	Phosphatidylcholines	66-85	heparan sulfate proteoglycan 2 L homeolog	Xenopus laevis	174-177
1659906-1	1991	Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils.	Phosphatidylcholines	69-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
1954254-1	1991	Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae.	Phosphatidylcholines	220-239	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	118-122
1954254-1	1991	Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae.	Phosphatidylcholines	220-239	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	127-131
1954254-9	1991	This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway.	Phosphatidylcholines	99-118	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	44-48
1954254-9	1991	This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway.	Phosphatidylcholines	99-118	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	58-62
1932100-6	1991	Phosphatidylcholine accounted for 84.8% of the phospholipids copurified with SP-D.	Phosphatidylcholines	0-19	surfactant protein D	Rattus norvegicus	77-81
1655413-0	1991	Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis.	Phosphatidylcholines	66-85	heparan sulfate proteoglycan 2 L homeolog	Xenopus laevis	226-229
1655413-0	1991	Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis.	Phosphatidylcholines	202-221	heparan sulfate proteoglycan 2 L homeolog	Xenopus laevis	174-177
1655413-0	1991	Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Recent evidence has accumulated showing that activation of PLC-catalysed hydrolysis of phosphatidylcholine (PC-PLC) is a critical step in mitogenic signal transduction both in fibroblasts and in oocytes from Xenopus laevis.	Phosphatidylcholines	202-221	heparan sulfate proteoglycan 2 L homeolog	Xenopus laevis	226-229
1936266-4	1991	We found that IL3 stimulated the formation of diacylglycerol independently of inositol lipid turnover, but concomitantly with increased turnover of phosphatidylcholine.	Phosphatidylcholines	148-167	interleukin 3	Mus musculus	14-17
1774014-3	1991	1) Influence of modified membrane cholesterol contents on insulin binding to erythrocytes (in vitro experiments): The cholesterol content of human erythrocyte membranes was modified by incubating the cells with phosphatidylcholine/cholesterol and phosphatidylcholine vesicles.	Phosphatidylcholines	211-230	insulin	Homo sapiens	58-65
1774014-6	1991	Phosphatidylcholine spin probe showed a dual effect of cholesterol on membrane fluidity, fluidizing below but rigidifying membranes above 20 degrees C. It is suggested that membrane cholesterol affects insulin receptor behavior through alteration of membrane fluidity, depending on the phase state of the membranes.	Phosphatidylcholines	0-19	insulin	Homo sapiens	202-209
1783615-12	1991	The isoforms nsLTP-A, -B, -C, and -D showed similar transfer activity not only for phosphatidylcholine and phosphatidylethanolamine but also for monogalactosyldiacylglycerol, although the homology among their amino acid sequences ranged from 70 to 30%.	Phosphatidylcholines	83-102	non-specific lipid-transfer protein C, cotyledon-specific isoform-like	Ricinus communis	13-36
1961199-7	1991	Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding.	Phosphatidylcholines	42-61	perforin 1	Homo sapiens	124-133
1961199-7	1991	Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding.	Phosphatidylcholines	42-61	perforin 1	Homo sapiens	233-242
1816683-1	1991	Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates.	Phosphatidylcholines	177-197	phospholipase A2 group IB	Rattus norvegicus	0-16
1816683-1	1991	Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates.	Phosphatidylcholines	199-201	phospholipase A2 group IB	Rattus norvegicus	0-16
1748624-6	1991	Deletion experiments evidenced the prominent role of pyruvate, transferrin, and selenium in the stimulation of surfactant PC biosynthesis.	Phosphatidylcholines	122-124	transferrin	Homo sapiens	63-74
1658188-6	1991	Further extensive examination of changes in metabolically labeled phospholipids indicated that TNF-stimulated hydrolysis of PC is accompanied by the generation of phosphorylcholine and DAG.	Phosphatidylcholines	124-126	tumor necrosis factor	Homo sapiens	95-98
1655762-8	1991	Similarly, egg yolk phosphatidylcholine complexes containing CF4 (CF4.egg PC) showed higher affinity binding than CF1-egg yolk phosphatidylcholine complexes confirming the results obtained with DMPC complexes.	Phosphatidylcholines	127-146	Cardiac cell morphology QTL 1	Rattus norvegicus	114-117
1918982-6	1991	Stimulation of quiescent cells with IL-3 produced an acute increase in the mass of both alkylacylglycerol and diacylglycerol, consistent with phosphatidylcholine as a significant source.	Phosphatidylcholines	142-161	interleukin 3	Mus musculus	36-40
1918982-10	1991	These results indicate a role for DG, generated through the hydrolysis of phosphatidylcholine, in the induction of protein kinase C activity and the events leading to cell proliferation in response to IL-3.	Phosphatidylcholines	74-93	interleukin 3	Mus musculus	201-205
1659382-4	1991	PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis.	Phosphatidylcholines	37-43	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	204-219
1659382-4	1991	PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis.	Phosphatidylcholines	37-43	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	221-224
1659382-8	1991	Down-regulation of protein kinase C (PKC), by pre-treatment with phorbol 12-myristate 13-acetate, abolished both [3H]choline and [3H]PtdBut formation, suggesting that PLD-catalysed PtdCho hydrolysis may be dependent on PKC activation, supporting its dependence on prior PtdIns(4,5)P2 hydrolysis.	Phosphatidylcholines	181-187	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-170
1910818-7	1991	We conclude that EGF may contribute significantly to the normal onset of lung maturation by elaborating a fibroblast-derived factor that stimulates phosphatidylcholine synthesis in type II pneumocytes.	Phosphatidylcholines	148-167	epidermal growth factor like 1	Rattus norvegicus	17-20
1656217-0	1991	v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.	Phosphatidylcholines	88-107	Rous sarcoma oncogene	Mus musculus	2-5
1765979-6	1991	Among the patients there was one with a variant of PAPS with hemolytic anemia and an IgM antibody to phosphatidylcholine that is akin to the natural autoantibody of normal mice encoded by germline genes VH11 and VH12.	Phosphatidylcholines	101-120	immunoglobulin heavy chain (V12 family)	Mus musculus	212-216
1839615-2	1991	The phospholipid-binding properties of CPB-II were investigated by measuring the binding constants of [125I]-CPB-II using phospholipid vesicles consisting of 80% phosphatidylcholine and 20% phosphatidylserine.	Phosphatidylcholines	162-181	annexin A6	Homo sapiens	39-45
1717480-2	1991	Egg phosphatidylcholine (PC) bilayers were reconstituted with two anchorage isoforms of the adhesion molecule lymphocyte function-associated antigen 3 (LFA-3).	Phosphatidylcholines	25-27	CD58 molecule	Homo sapiens	152-157
1656217-2	1991	v-Src-induced increases in radiolabeled DAG were most readily detected when phospholipids were prelabeled with myristic acid, which is incorporated predominantly into phosphatidylcholine.	Phosphatidylcholines	167-186	Rous sarcoma oncogene	Mus musculus	2-5
1894612-4	1991	2) With [3H]cholesterol/phosphatidylcholine liposomes, the cholesterol binding parameters for L-FABP were Kd = 1.53 +/- 0.28 microM and stoichiometry 0.83 +/- 0.07 mol/mol.	Phosphatidylcholines	24-43	fatty acid binding protein 1	Rattus norvegicus	94-100
1892885-9	1991	Measurement of the activity of phospholipase A with endogenously [3H]choline-labeled PC showed that the formation of lysoPC in mitochondria isolated form choline-supplemented cells was 40% lower than in choline-deficient cells.	Phosphatidylcholines	85-87	phospholipase A and acyltransferase 1	Rattus norvegicus	31-46
1653607-6	1991	Mixed vesicles of PIP2 with phosphatidylcholine or phosphatidylethanolamine also inhibit CapZ, but addition of Triton X-100 both prevents and reverses PIP2"s inhibition of CapZ.	Phosphatidylcholines	28-47	capping actin protein of muscle Z-line alpha subunit 2	Gallus gallus	89-93
1892886-6	1991	Supplementation of choline-deficient rat hepatocytes, prelabeled with [3H]choline, with dimethylethanolamine increased the catabolism of PC by 1.6-fold after 6 h. This effect was accompanied by a 2.5-fold increase in the production of [3H]glycerophosphocholine (GPC).	Phosphatidylcholines	137-139	glycophorin C	Rattus norvegicus	262-265
1665301-0	1991	Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D.	Phosphatidylcholines	96-115	colony stimulating factor 2	Homo sapiens	0-48
1654115-4	1991	These results show that phospholipase A2 was activated in hypoxic myocytes and had substrate specificity towards PC and PE.	Phosphatidylcholines	113-115	phospholipase A2 group IB	Homo sapiens	24-40
1653227-1	1991	Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5.	Phosphatidylcholines	28-47	colony stimulating factor 1 (macrophage)	Mus musculus	130-157
1653227-1	1991	Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5.	Phosphatidylcholines	49-55	colony stimulating factor 1 (macrophage)	Mus musculus	130-157
1653227-1	1991	Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during the G1 stage of the cell cycle was investigated in the colony-stimulating factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5.	Phosphatidylcholines	49-55	colony stimulating factor 1 (macrophage)	Mus musculus	159-164
1653227-4	1991	Metabolic labeling experiments pointed to CTP:phosphocholine cytidylyltransferase (CT) as the rate-controlling enzyme for PtdCho biosynthesis in BAC1.2F5 cells.	Phosphatidylcholines	122-128	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	42-81
1665301-0	1991	Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D.	Phosphatidylcholines	96-115	colony stimulating factor 2	Homo sapiens	50-56
1665301-0	1991	Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D.	Phosphatidylcholines	96-115	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	129-144
1665301-2	1991	To further define the mechanism by which GM-CSF up-regulates PLD activity, we investigated the effect of GM-CSF pretreatment of neutrophils on phosphatidylcholine breakdown in response to a receptor-coupled stimulus N-formyl-methionyl-leucyl-phenylalanine (fMLP) and to a receptor-independent stimulus phorbol-myristate-acetate (PMA).	Phosphatidylcholines	143-162	colony stimulating factor 2	Homo sapiens	105-111
1665301-4	1991	The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor.	Phosphatidylcholines	38-57	colony stimulating factor 2	Homo sapiens	18-24
1665301-4	1991	The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor.	Phosphatidylcholines	38-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	74-77
1665301-4	1991	The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor.	Phosphatidylcholines	38-57	formyl peptide receptor 1	Homo sapiens	164-177
1793570-4	1991	These cells were shown to possess phosphatidylcholine-dependent BDH activity.	Phosphatidylcholines	34-53	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	64-67
1660725-2	1991	The conversion of membrane from AChE to soluble AChE by PI-PLC depended on the presence of a detergent and of phosphatidylcholine.	Phosphatidylcholines	110-129	acetylcholinesterase	Bos taurus	32-36
1660725-2	1991	The conversion of membrane from AChE to soluble AChE by PI-PLC depended on the presence of a detergent and of phosphatidylcholine.	Phosphatidylcholines	110-129	acetylcholinesterase	Bos taurus	48-52
1660725-3	1991	In presence of mixed micelles containing Triton X-100 (0.05%) and phosphatidylcholine (0.5 mg/ml) the rate of AChE conversion was about 3 times higher than in presence of Triton X-100 alone.	Phosphatidylcholines	66-85	acetylcholinesterase	Bos taurus	110-114
1892881-3	1991	This enhancement of the cytosolic 15-lipoxygenase activity, which was reversible by EGTA, was inhibited by phosphatidyl serine and phosphatidyl choline.	Phosphatidylcholines	131-151	arachidonate 15-lipoxygenase	Homo sapiens	34-49
1652765-8	1991	The rate of incorporation of 14C from [14C]choline into GPC, the steady-state GPC synthesis rate, and the activity of phospholipase A2 (which can catalyze a step in the synthesis of GPC from phosphatidylcholine) are not increased by high NaCl and urea.	Phosphatidylcholines	191-210	phospholipase A2 group IB	Canis lupus familiaris	118-134
1788877-0	1991	[Anabolic action of prolactin on phosphatidylcholine metabolism in guinea pig adrenocorticocytes].	Phosphatidylcholines	33-52	prolactin	Cavia porcellus	20-29
1788877-1	1991	Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control.	Phosphatidylcholines	125-144	prolactin	Cavia porcellus	64-73
1788877-1	1991	Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control.	Phosphatidylcholines	125-144	prolactin	Cavia porcellus	75-78
1788877-3	1991	The rate of disappearance of labelled phosphatidylcholine in adrenocortical cells prelabelled with [3H] choline was lower in cells obtained from PRL-treated animals.	Phosphatidylcholines	38-57	prolactin	Cavia porcellus	145-148
1788877-6	1991	The obtained data showed that prolonged influence of PRL caused a shift of the phosphatidylcholine metabolism to anabolism.	Phosphatidylcholines	79-98	prolactin	Cavia porcellus	53-56
1878372-9	1991	Freshly prepared Glut 1 retained high activity after separation from membrane lipids on a TSKgel G3000SW column in the presence of 40 mM octyl glucoside and 1 mM PS or PC.	Phosphatidylcholines	168-170	solute carrier family 2 member 1	Homo sapiens	17-23
1878372-11	1991	The presence of a phospholipid was thus essential for retention of high activity of the Glut 1 in octyl glucoside and PC was nearly as effective as PS.	Phosphatidylcholines	118-120	solute carrier family 2 member 1	Homo sapiens	88-94
1908796-2	1991	This activity is mainly distributed in the microsomal fraction (76.5% of total) and has properties similar to the mammalian PAF-acetylhydrolase since it is Ca(2+)-independent, acid-labile, is inhibited by DFP and PMSF but it is not affected by egg yolk phosphatidylcholine.	Phosphatidylcholines	253-272	phospholipase A2 group VII	Homo sapiens	124-143
1770112-1	1991	A simple procedure is described for the purification of phosphatidylcholine-hydrolyzing phospholipase C(PLC).	Phosphatidylcholines	56-75	heparan sulfate proteoglycan 2	Homo sapiens	104-107
1872854-1	1991	An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 alpha-receptor expression.	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	77-93
1770308-0	1991	Characterization of the discoidal complexes formed between apoA-I-CNBr fragments and phosphatidylcholine.	Phosphatidylcholines	85-104	apolipoprotein A1	Homo sapiens	59-65
2061317-0	1991	Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+.	Phosphatidylcholines	58-77	cut like homeobox 1	Homo sapiens	35-38
1854730-6	1991	The initial decrease in Tm (delta H or delta S) with increasing values of delta C/CL is attributed to the progressive increase in the magnitude of the chain-terminal perturbations on the conformational statistics of the adjacent hydrocarbon chains and hence the lateral chain-chain interactions of these mixed-chain phosphatidylcholines in the gel-state bilayer.	Phosphatidylcholines	316-336	crystallin gamma C	Homo sapiens	80-84
1854740-4	1991	The action of PLA2 on phosphatidylcholine (PC) vesicles containing a small amount of anionic phospholipid, such as phosphatidic acid (PA), was studied.	Phosphatidylcholines	22-41	phospholipase A2, major isoenzyme	Sus scrofa	14-18
1854740-4	1991	The action of PLA2 on phosphatidylcholine (PC) vesicles containing a small amount of anionic phospholipid, such as phosphatidic acid (PA), was studied.	Phosphatidylcholines	43-45	phospholipase A2, major isoenzyme	Sus scrofa	14-18
1854804-1	1991	The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho.	Phosphatidylcholines	19-38	cut like homeobox 1	Homo sapiens	168-171
1854804-1	1991	The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho.	Phosphatidylcholines	40-46	cut like homeobox 1	Homo sapiens	168-171
1906891-6	1991	The rIL-1-stimulated PLA2 had an alkaline pH optimum, and phosphatidylethanolamine was preferred over phosphatidylcholine as substrate.	Phosphatidylcholines	102-121	phospholipase A2 group IIA	Homo sapiens	21-25
2061317-1	1991	The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline.	Phosphatidylcholines	237-248	cut like homeobox 1	Homo sapiens	92-95
2061317-11	1991	These results suggest that channeling of intermediates in the CDP-choline pathway of Ptd-choline biosynthesis in glioma cells is mediated by intracellular Ca2+ levels that may coordinately regulate the steps involved in conversion of choline to Ptd-choline.	Phosphatidylcholines	85-96	cut like homeobox 1	Homo sapiens	62-65
2061317-1	1991	The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline.	Phosphatidylcholines	19-38	cut like homeobox 1	Homo sapiens	92-95
2061317-1	1991	The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline.	Phosphatidylcholines	19-38	cut like homeobox 1	Homo sapiens	219-222
2061317-1	1991	The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline.	Phosphatidylcholines	40-51	cut like homeobox 1	Homo sapiens	92-95
2061317-1	1991	The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline.	Phosphatidylcholines	40-51	cut like homeobox 1	Homo sapiens	219-222
1654818-1	1991	Cytochrome c(3+)-catalyzed peroxidation of phosphatidylcholine liposomes by hydrogen peroxide (H2O2) was indicated by the production of thiobarbituric acid reactive substances, oxygen consumption, and emission of spontaneous chemiluminescence.	Phosphatidylcholines	43-62	cytochrome c, somatic	Homo sapiens	0-12
1903207-6	1991	Phosphatidylcholine (PC) and phosphatidylinositol turnover were increased by insulin (P less than 0.025 and less than 0.05, respectively).	Phosphatidylcholines	0-19	insulin	Homo sapiens	77-84
2040620-6	1991	To identify potential substrates, we synthesized phosphatidylcholines with sn-2 residues from two to nine carbon atoms long, and found the V/k ratio decreased as the sn-2 residue was lengthened: the C5 homolog was 50%, the C6 20%, while the C9 homolog was only 2% as efficient as PAF.	Phosphatidylcholines	49-69	PCNA clamp associated factor	Homo sapiens	280-283
2037585-1	1991	I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA).	Phosphatidylcholines	70-89	kininogen 1	Homo sapiens	161-171
2037585-1	1991	I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA).	Phosphatidylcholines	70-89	kininogen 1	Homo sapiens	173-175
1934174-1	1991	The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied.	Phosphatidylcholines	69-88	interferon gamma	Homo sapiens	37-53
1934174-1	1991	The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied.	Phosphatidylcholines	69-88	interferon gamma	Homo sapiens	55-58
1646299-8	1991	Phosphatidylcholine-mediated delivery of anti-GAP-43 antibodies (alpha GAP) into cells immediately before dbcAMP treatment arrested neuritogenesis but did not induce the retraction of existing neurites.	Phosphatidylcholines	0-19	growth associated protein 43	Mus musculus	46-52
1920900-0	1991	[The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini].	Phosphatidylcholines	45-64	cholecystokinin	Rattus norvegicus	26-41
1920900-3	1991	Pulse-chase study revealed that CCK reduced both the disappearance of phosphocholine and the synthesis of PC.	Phosphatidylcholines	106-108	cholecystokinin	Rattus norvegicus	32-35
1920900-6	1991	These results suggest that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP: phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	40-42	cholecystokinin	Rattus norvegicus	27-30
1920900-6	1991	These results suggest that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP: phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	40-42	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	135-175
2059651-1	1991	We investigate various models of the hydrolysis of gel-phase phosphatidylcholine monolayers by phospholipase A2 (Grainger et al.	Phosphatidylcholines	61-80	phospholipase A2 group IB	Homo sapiens	95-111
2059654-6	1991	The data demonstrate that, in MDCK cells: (a) PC-TP can modify the PC species present in the plasma membrane; (b) PC accounts for a significant amount of the polar lipids present in the external leaflet of the apical membrane domain.	Phosphatidylcholines	67-69	phosphatidylcholine transfer protein	Canis lupus familiaris	46-51
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	0-19	kininogen 1	Homo sapiens	90-100
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	0-19	kininogen 1	Homo sapiens	102-104
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	181-200	kininogen 1	Homo sapiens	90-100
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	181-200	kininogen 1	Homo sapiens	102-104
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	202-204	kininogen 1	Homo sapiens	90-100
2037586-2	1991	Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C. Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend, R.L.	Phosphatidylcholines	202-204	kininogen 1	Homo sapiens	102-104
2037586-6	1991	Stimulation with BK resulted in the rapid and synchronous formation of [3H]choline and [3H]myristoyl-PA from the correspondingly prelabeled PC, indicative of phospholipase D (PLD) activity.	Phosphatidylcholines	140-142	kininogen 1	Homo sapiens	17-19
2037586-6	1991	Stimulation with BK resulted in the rapid and synchronous formation of [3H]choline and [3H]myristoyl-PA from the correspondingly prelabeled PC, indicative of phospholipase D (PLD) activity.	Phosphatidylcholines	140-142	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	158-173
1903207-6	1991	Phosphatidylcholine (PC) and phosphatidylinositol turnover were increased by insulin (P less than 0.025 and less than 0.05, respectively).	Phosphatidylcholines	21-23	insulin	Homo sapiens	77-84
1903207-10	1991	We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC.	Phosphatidylcholines	131-133	insulin	Homo sapiens	17-24
1903207-10	1991	We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC.	Phosphatidylcholines	244-246	insulin	Homo sapiens	17-24
1654804-0	1991	Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells.	Phosphatidylcholines	26-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-70
1828227-6	1991	A dose-dependent inhibition of phospholipase A2 by both annexins VI and IV, at millimolar concentrations of Ca2+ was observed when phosphatidylcholine liposomes were used as a substrate.	Phosphatidylcholines	131-150	phospholipase A2 group IB	Homo sapiens	31-47
1828037-1	1991	Mouse NIH 3T3 fibroblasts transfected with human colony stimulating factor-1 receptor produced diacylglycerol in response to CSF1 and this correlated with elevated phosphatidylcholine hydrolyzing activity measured in an in vitro assay.	Phosphatidylcholines	164-183	colony stimulating factor 1 receptor	Homo sapiens	49-85
1903932-0	1991	Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells.	Phosphatidylcholines	23-42	angiotensinogen	Homo sapiens	0-14
1828037-1	1991	Mouse NIH 3T3 fibroblasts transfected with human colony stimulating factor-1 receptor produced diacylglycerol in response to CSF1 and this correlated with elevated phosphatidylcholine hydrolyzing activity measured in an in vitro assay.	Phosphatidylcholines	164-183	colony stimulating factor 1	Homo sapiens	125-129
2026154-1	1991	We have compared the action of lipoprotein lipase on liposomes of egg yolk phosphatidylcholine containing less than saturating amounts of trioleoylglycerol (less than 3%) and emulsion droplets of the same lipids.	Phosphatidylcholines	75-94	lipoprotein lipase	Homo sapiens	31-49
2036455-0	1991	Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E.	Phosphatidylcholines	39-58	lipase C, hepatic type	Homo sapiens	14-28
2036455-0	1991	Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E.	Phosphatidylcholines	39-58	apolipoprotein E	Homo sapiens	73-89
2036455-1	1991	The effect of apolipoproteins A-I, A-II, C-II, C-III and E on the hydrolysis of phosphatidylcholine and triacylglycerol by hepatic lipase was studied.	Phosphatidylcholines	80-99	NLR family pyrin domain containing 3	Homo sapiens	14-39
2036455-1	1991	The effect of apolipoproteins A-I, A-II, C-II, C-III and E on the hydrolysis of phosphatidylcholine and triacylglycerol by hepatic lipase was studied.	Phosphatidylcholines	80-99	lipase C, hepatic type	Homo sapiens	123-137
1910734-11	1991	Addition of bovine serum albumin (fatty acid free) to assays increased the rate of release of arachidonate from phosphatidylcholine, but not from phosphatidylethanolamine.	Phosphatidylcholines	112-131	albumin	Homo sapiens	19-32
1663404-3	1991	ESR measurements of 5-doxyl stearic acid, as a spin probe, show that PAF disorients phosphatidylcholine bilayers when present at molar ratios greater than 40%.	Phosphatidylcholines	84-103	PCNA clamp associated factor	Homo sapiens	69-72
2022654-5	1991	In the presence of phosphatidylcholine/phosphatidylserine vesicles and factor Va, two of the antibodies, alpha HII-3 and alpha HII-4, inhibited prothrombin activation at a 90 and 50% level, respectively.	Phosphatidylcholines	19-38	coagulation factor II, thrombin	Homo sapiens	144-155
2022747-3	1991	Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE.	Phosphatidylcholines	112-131	phospholipase A2 group IB	Rattus norvegicus	13-17
2022747-3	1991	Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE.	Phosphatidylcholines	133-135	phospholipase A2 group IB	Rattus norvegicus	13-17
2016297-0	1991	Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.	Phosphatidylcholines	55-74	insulin S homeolog	Xenopus laevis	131-138
1708286-8	1991	CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine.	Phosphatidylcholines	67-86	cholecystokinin	Rattus norvegicus	0-3
1708286-8	1991	CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine.	Phosphatidylcholines	67-86	phospholipase A and acyltransferase 1	Rattus norvegicus	25-40
1708286-8	1991	CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine.	Phosphatidylcholines	67-86	phospholipase A and acyltransferase 1	Rattus norvegicus	42-45
1708286-10	1991	The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation.	Phosphatidylcholines	174-193	cholecystokinin	Rattus norvegicus	51-54
1708286-10	1991	The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation.	Phosphatidylcholines	174-193	phospholipase A and acyltransferase 1	Rattus norvegicus	148-151
2016306-6	1991	The main step in the catabolism of 1-acyl-2-acetyl-GPC is the removal of the long chain at the sn-1 position; the long chain residue is subsequently incorporated either into triglycerides or into phosphatidylcholine.	Phosphatidylcholines	196-215	glycophorin C (Gerbich blood group)	Homo sapiens	51-54
1902664-5	1991	Thrombin stimulated the decrease in PtdIns and phosphatidylcholine contents.	Phosphatidylcholines	47-66	coagulation factor II, thrombin	Homo sapiens	0-8
2016297-0	1991	Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.	Phosphatidylcholines	55-74	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	147-150
2016297-1	1991	Recent studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine both by growth factors and by the product of ras oncogene, ras p21.	Phosphatidylcholines	90-109	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	173-176
2018133-3	1991	Differences in the distribution of phosphatidylcholine and phosphatidylethanolamine, as assessed by phospholipase A2 treatment and trinitrophenylation of aminophospholipids, were, at least partially, responsible for the asymmetrical fluidity of the hemileaflets.	Phosphatidylcholines	35-54	phospholipase A2 group IB	Rattus norvegicus	100-116
2012808-7	1991	The insertion at amino acid 379 occurs immediately after a triplet of lysine residues, suggesting that this region might be involved in an essential step in the mechanism of CE and TG transfer, such as the binding of CETP to phosphatidylcholine molecules in the lipoprotein surface.	Phosphatidylcholines	225-244	cholesteryl ester transfer protein	Homo sapiens	217-221
2007582-3	1991	In the absence of added Ca2+ adriamycin caused a 3-4-fold activation of hydrolysis of this pyrenelipid whereas an inhibition of action of PLA2 on the corresponding phosphatidylcholine derivative C28-O-PHPC was observed.	Phosphatidylcholines	164-183	phospholipase A2 group IB	Homo sapiens	138-142
1829383-0	1991	Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG).	Phosphatidylcholines	47-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-101
1910288-3	1991	Tumor-derived cells exhibited significant PLA2 activity(ies) with arachidonoyl containing phosphatidylcholine and phosphatidylethanolamine as substrates in cell-free assays.	Phosphatidylcholines	90-109	phospholipase A2, group IB, pancreas	Mus musculus	42-46
1910288-6	1991	The pH profiles for hydrolysis of phosphatidylcholine and phosphatidylethanolamine differed; all other aspects of PLA2-mediated hydrolysis of these two substrates were similar including a Ca2+ requirement for activity.	Phosphatidylcholines	34-53	phospholipase A2, group IB, pancreas	Mus musculus	114-118
1829383-0	1991	Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG).	Phosphatidylcholines	47-66	phospholipase D1	Homo sapiens	147-170
1829383-0	1991	Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG).	Phosphatidylcholines	231-250	phospholipase D1	Homo sapiens	147-170
1829383-0	1991	Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG).	Phosphatidylcholines	252-254	phospholipase D1	Homo sapiens	147-170
2019995-5	1991	Treatment of cells with A-4, A-5 and HC-3 resulted in an increase in the incorporation of S-adenosyl-methionine into phosphatidylcholine.	Phosphatidylcholines	117-136	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	24-27
2059659-6	1991	Furthermore, sustained increases in 1,2-diacylglycerol in response to alpha-thrombin are regulated at least in part at the level of generation (via phosphatidylcholine hydrolysis).	Phosphatidylcholines	148-167	coagulation factor II, thrombin	Homo sapiens	76-84
2019995-5	1991	Treatment of cells with A-4, A-5 and HC-3 resulted in an increase in the incorporation of S-adenosyl-methionine into phosphatidylcholine.	Phosphatidylcholines	117-136	laminin, alpha 5	Mus musculus	29-32
2019995-7	1991	Phosphatidylcholine turnover was decreased in cells treated with A-4 and A-5.	Phosphatidylcholines	0-19	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	65-68
2019995-7	1991	Phosphatidylcholine turnover was decreased in cells treated with A-4 and A-5.	Phosphatidylcholines	0-19	laminin, alpha 5	Mus musculus	73-76
2019995-8	1991	A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway.	Phosphatidylcholines	156-175	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	0-3
2019995-8	1991	A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway.	Phosphatidylcholines	156-175	laminin, alpha 5	Mus musculus	5-8
2019995-8	1991	A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway.	Phosphatidylcholines	191-210	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	0-3
2019995-8	1991	A-4, A-5 and HC-3 produce significant decreases in choline metabolism; however, the cells are able to maintain membrane integrity by decreasing turnover of phosphatidylcholine and increasing phosphatidylcholine synthesis through the methylation pathway.	Phosphatidylcholines	191-210	laminin, alpha 5	Mus musculus	5-8
2002032-10	1991	At a high surface pressure of 25 mN/m all apolipoproteins tested (apolipoproteins A-I, A-II, C-I, C-II, C-III, and E) inhibited the penetration into and HL activity on phosphatidylethanolamine At 18.5 mN/m all apolipoproteins except apolipoprotein E inhibited the hydrolysis of triacylglycerol in the triacylglycerol:phosphatidylcholine mixed film.	Phosphatidylcholines	317-336	NLR family pyrin domain containing 3	Homo sapiens	42-96
1826088-2	1991	In this study, experiments are presented that utilize a pyrene derivative of phosphatidylcholine to examine the Ca2(+)-dependent membrane binding of soluble human annexin V and other annexins.	Phosphatidylcholines	77-96	annexin A5	Homo sapiens	163-172
1997207-1	1991	SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function.	Phosphatidylcholines	46-65	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-6
1999422-11	1991	Therefore, the lipid-containing vesicles derived from endoplasmic reticulum must have combined with cis Golgi apparatus membranes as the basis for Golgi apparatus-dependent phospholipase A processing of endoplasmic reticulum-derived phosphatidylcholine.	Phosphatidylcholines	233-252	phospholipase A and acyltransferase 1	Rattus norvegicus	173-188
1907204-7	1991	Together with the observation that PC was found to decrease upon BK stimulation, these observations suggest that the late phase of DAG accumulation may involve breakdown of other phospholipids including PC.	Phosphatidylcholines	35-37	kininogen 1	Homo sapiens	65-67
2027529-1	1991	Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells.	Phosphatidylcholines	252-271	endothelin 1	Rattus norvegicus	29-41
2027529-1	1991	Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells.	Phosphatidylcholines	252-271	endothelin 1	Rattus norvegicus	43-45
2027529-1	1991	Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells.	Phosphatidylcholines	273-275	endothelin 1	Rattus norvegicus	29-41
1997207-4	1991	The antagonistic action of the CKI gene product on SEC14p function revealed a previously unsuspected influence of biosynthetic activities of the CDP-choline pathway for PC biosynthesis on yeast Golgi function and indicated that SEC14p controls the phospholipid content of yeast Golgi membranes in vivo.	Phosphatidylcholines	169-171	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	51-57
2027529-1	1991	Stimulation of C6 cells with endothelin-1 (ET) caused a biphasic sn-1,2-diacylglycerol (1,2-DG) generation, which occurred not only via phosphatidylinositol 4,5-P2 (PIP2) hydrolysis by specific phospholipase C action, but also through the breakdown of phosphatidylcholine (PC) induced by either PC phospholipase C or D. ET also stimulated DNA synthesis in serum-starved C6 cells.	Phosphatidylcholines	273-275	endothelin 1	Rattus norvegicus	43-45
2027529-4	1991	In addition to other possible roles, ET may also mediate mitogenesis in the brain, presumably through a PKC-dependent activation of phospholipase C and/or D hydrolyzing PC.	Phosphatidylcholines	169-171	endothelin 1	Rattus norvegicus	37-39
2038071-8	1991	In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	204-223	phospholipase A2 group IB	Homo sapiens	156-172
1993681-8	1991	In the complex of lipids and apoA-I or apoA-II, the weight ratios of apolipoprotein/cholesterol/phosphatidylcholine/sphingomyelin/lysophosphatidyl- choline were estimated as 2.2:1:0.6:0.2:0.07 and 4.0:1:0.5:0.3:0.07, respectively.	Phosphatidylcholines	96-115	apolipoprotein A1	Homo sapiens	29-35
1993681-8	1991	In the complex of lipids and apoA-I or apoA-II, the weight ratios of apolipoprotein/cholesterol/phosphatidylcholine/sphingomyelin/lysophosphatidyl- choline were estimated as 2.2:1:0.6:0.2:0.07 and 4.0:1:0.5:0.3:0.07, respectively.	Phosphatidylcholines	96-115	apolipoprotein A2	Homo sapiens	39-46
1993695-1	1991	Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.	Phosphatidylcholines	40-59	coagulation factor II, thrombin	Homo sapiens	90-98
1898904-8	1991	Phosphorylcholine, a product of phospholipase C activity on the major lung surfactant phosphatidylcholine, was also used as a growth substrate in nutrient limitation studies.	Phosphatidylcholines	86-105	phospholipase C	Pseudomonas aeruginosa PAO1	32-47
1999479-8	1991	In cells labelled with [3H]choline, the water soluble phosphatidylcholine hydrolysis products, phosphorylcholine and choline, were increased 2-fold within 5 minutes of addition of EGF.	Phosphatidylcholines	54-73	epidermal growth factor	Homo sapiens	180-183
1999479-16	1991	Thus, the induction of 1,2-diacylglycerol by EGF may occur primarily via phospholipase C-catalyzed hydrolysis of phosphatidylcholine.	Phosphatidylcholines	113-132	epidermal growth factor	Homo sapiens	45-48
2038071-8	1991	In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	204-223	phospholipase A2 group IB	Homo sapiens	174-178
2038071-8	1991	In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	89-91	phospholipase A2 group IB	Homo sapiens	156-172
2038071-8	1991	In crude homogenates of myocardial tissue, the total enzymic activity for catabolism of LPC far exceeds the total activity for synthesis of LPC mediated by phospholipase A2 (PLA2) catalyzed hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	89-91	phospholipase A2 group IB	Homo sapiens	174-178
1991158-8	1991	These results suggest that an eicosanoid-independent degradation of phosphatidylethanolamine via phospholipase A2 at lower collagen levels may provide a source of the initial AA for conversion to TxA2 and the subsequent deacylation of phosphatidylinositol, phosphatidylcholine, and also phosphatidylserine.	Phosphatidylcholines	257-276	phospholipase A2 group IB	Homo sapiens	97-113
2051995-3	1991	Direct evidence came when liposomes made of egg yolk phosphatidylcholine, containing both [14C]labeled phospholipids and [1-14C] palmitic acid were incubated with FABP.	Phosphatidylcholines	53-72	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	163-167
1900197-1	1991	C-reactive protein was highly purified from Japanese eel (Anguilla japonica) serum by precipitation with phosphatidyl-choline and Ca2+.	Phosphatidylcholines	105-125	C-reactive protein	Homo sapiens	0-18
1899026-1	1991	Chromaffin granule membranes prepared from bovine adrenal medullae showed Ca2(+)-stimulated phospholipase A2 (PLA2) activity when assayed at pH 9.0 with phosphatidylcholine containing an [14C]-arachidonyl group in the 2-position.	Phosphatidylcholines	153-172	LOC104974671	Bos taurus	92-108
1899026-1	1991	Chromaffin granule membranes prepared from bovine adrenal medullae showed Ca2(+)-stimulated phospholipase A2 (PLA2) activity when assayed at pH 9.0 with phosphatidylcholine containing an [14C]-arachidonyl group in the 2-position.	Phosphatidylcholines	153-172	LOC104974671	Bos taurus	110-114
1985909-2	1991	PKC association to a mixed phospholipid film (phosphatidylcholine, phosphatidylserine) could be detected by an increase of the monolayer surface pressure.	Phosphatidylcholines	46-65	proline rich transmembrane protein 2	Homo sapiens	0-3
1776744-2	1991	Experimental studies have shown that the administration of CDP-choline increases the total amount of phosphatidylcholine and other related phospholipids in the brain and in some cases may enhance neurotransmission.	Phosphatidylcholines	101-120	cut like homeobox 1	Homo sapiens	59-62
1723301-1	1991	Carbonic anhydrase (CA) from mouse erythrocyte membranes is recognised as an autoantigen in Western blotting experiments with FUB 1, a murine IgM monoclonal antibody that binds both phosphatidylcholine and bromelain-treated mouse red blood cells (BrMRBC).	Phosphatidylcholines	182-201	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	126-131
1854590-2	1991	Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol.	Phosphatidylcholines	84-103	interleukin 2	Rattus norvegicus	18-31
1648354-0	1991	[Recombination of micellar complexes of apolipoprotein A1--phosphatidylcholine in the presence of complex components].	Phosphatidylcholines	59-78	apolipoprotein A1	Homo sapiens	40-57
1648355-7	1991	These data show the importance of hydrophobic protein-protein interactions for the structure of HDL and synthetic complexes of apoA1 with phosphatidyl choline.	Phosphatidylcholines	138-158	apolipoprotein A1	Homo sapiens	127-132
1859438-3	1991	Comparative studies on the effects of pH, salt, and temperature on the phosphatidylcholine transfer activity revealed that PC-TP from porcine and bovine livers were similar as far as its activity is concerned.	Phosphatidylcholines	71-90	phosphatidylcholine transfer protein	Bos taurus	123-128
1854590-2	1991	Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol.	Phosphatidylcholines	84-103	interleukin 2	Rattus norvegicus	33-37
1854590-2	1991	Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol.	Phosphatidylcholines	105-107	interleukin 2	Rattus norvegicus	18-31
1854590-2	1991	Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol.	Phosphatidylcholines	105-107	interleukin 2	Rattus norvegicus	33-37
1875789-4	1991	In addition, pretreatment of culture with the combination of superoxide dismutase and catalase inhibited the increase in PC secretion.	Phosphatidylcholines	121-123	catalase	Rattus norvegicus	86-94
1657391-6	1991	On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone.	Phosphatidylcholines	73-92	C-reactive protein	Homo sapiens	19-22
1657391-6	1991	On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone.	Phosphatidylcholines	66-68	C-reactive protein	Homo sapiens	19-22
1657391-6	1991	On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone.	Phosphatidylcholines	94-96	C-reactive protein	Homo sapiens	19-22
1761153-9	1991	In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima.	Phosphatidylcholines	26-45	procollagen C-endopeptidase enhancer	Rattus norvegicus	47-49
1761153-9	1991	In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima.	Phosphatidylcholines	26-45	procollagen C-endopeptidase enhancer	Rattus norvegicus	106-111
1761153-9	1991	In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima.	Phosphatidylcholines	26-45	procollagen C-endopeptidase enhancer	Rattus norvegicus	195-200
27463477-9	1991	From 5-20% of normal adult CD5 B cells (and lymphomas) produce antibody reactive with phosphatidyl choline.	Phosphatidylcholines	86-106	CD5 antigen	Mus musculus	27-30
2246516-6	1990	When exogenous [3H]PAF was added to the two stimulated eosinophil populations subsequent analysis of the [3H]PAF metabolites by DIOL-HPLC revealed that low density eosinophils incorporated PAF into the phosphatidylcholine (PC) pool more rapidly than did normal density eosinophils or neutrophils.	Phosphatidylcholines	202-221	PCNA clamp associated factor	Homo sapiens	19-22
1997787-4	1991	Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates.	Phosphatidylcholines	160-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
1997787-4	1991	Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates.	Phosphatidylcholines	181-183	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-42
1997787-4	1991	Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates.	Phosphatidylcholines	181-183	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
2125219-0	1990	Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown.	Phosphatidylcholines	88-107	growth hormone	Mus musculus	37-51
2125219-6	1990	It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein.	Phosphatidylcholines	99-118	growth hormone	Mus musculus	21-35
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylcholines	170-189	tissue factor pathway inhibitor	Homo sapiens	41-45
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylcholines	170-189	coagulation factor III, tissue factor	Homo sapiens	70-83
2129343-5	1990	Incubation of PT cells with D-alpha-dipalmitoyl phosphatidylcholine (0-200 micrograms/ml medium) also stimulated the activity of GalT-2, maximum stimulation (200%) occurring with 25 micrograms phosphatidylcholine/ml medium.	Phosphatidylcholines	48-67	beta-1,3-galactosyltransferase 4	Homo sapiens	129-135
1997787-4	1991	Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates.	Phosphatidylcholines	160-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-42
2027252-2	1991	PLA2 activity was measured by radiochemical method using phosphatidylcholine as a substrate.	Phosphatidylcholines	57-76	phospholipase A2 group IB	Homo sapiens	0-4
2028524-1	1991	Methemoglobin effect on the structure of phosphatidylcholine liposomes was studied using sulfophthalein dye bromthymol blue.	Phosphatidylcholines	41-60	hemoglobin subunit gamma 2	Homo sapiens	0-13
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylcholines	105-124	tissue factor pathway inhibitor	Homo sapiens	41-45
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylcholines	105-124	coagulation factor III, tissue factor	Homo sapiens	70-83
2088393-0	1990	Hemolytic anemia related to an IgM autoantibody to phosphatidylcholine that binds in vitro to stored and to bromelain-treated human erythrocytes.	Phosphatidylcholines	51-70	immunoglobulin heavy constant mu	Mus musculus	31-34
2088393-1	1990	Both normal and autoimmune mice have IgM natural autoantibodies to bromelain-treated erythrocytes in which phosphatidylcholine (PTC) becomes exposed.	Phosphatidylcholines	107-126	immunoglobulin heavy constant mu	Mus musculus	37-40
2088393-1	1990	Both normal and autoimmune mice have IgM natural autoantibodies to bromelain-treated erythrocytes in which phosphatidylcholine (PTC) becomes exposed.	Phosphatidylcholines	128-131	immunoglobulin heavy constant mu	Mus musculus	37-40
2246516-6	1990	When exogenous [3H]PAF was added to the two stimulated eosinophil populations subsequent analysis of the [3H]PAF metabolites by DIOL-HPLC revealed that low density eosinophils incorporated PAF into the phosphatidylcholine (PC) pool more rapidly than did normal density eosinophils or neutrophils.	Phosphatidylcholines	223-225	PCNA clamp associated factor	Homo sapiens	19-22
2246516-7	1990	Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway.	Phosphatidylcholines	27-29	PCNA clamp associated factor	Homo sapiens	179-182
2246516-7	1990	Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway.	Phosphatidylcholines	27-29	PCNA clamp associated factor	Homo sapiens	195-198
2246516-7	1990	Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway.	Phosphatidylcholines	128-130	PCNA clamp associated factor	Homo sapiens	179-182
2093138-3	1990	This effect could be attributed to an enhancement by PGE1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e., the substrate and product of lecithin-cholesterol acyltransferase (LCAT).	Phosphatidylcholines	94-113	lecithin-cholesterol acyltransferase	Homo sapiens	173-209
2093138-3	1990	This effect could be attributed to an enhancement by PGE1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e., the substrate and product of lecithin-cholesterol acyltransferase (LCAT).	Phosphatidylcholines	94-113	lecithin-cholesterol acyltransferase	Homo sapiens	211-215
2246516-7	1990	Alkaline hydrolysis of the PC fraction from whole cell extracts followed by treatment with acetic anhydride resulted in all the PC-associated radioactivity being converted to [3H]PAF, confirming PAF incorporation to PC via this pathway.	Phosphatidylcholines	128-130	PCNA clamp associated factor	Homo sapiens	195-198
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylcholines	107-126	coagulation factor X	Homo sapiens	53-56
1701623-3	1990	The proportion of 18:2 in serum phosphatidylcholine correlated inversely with such acute phase proteins as orosomucoid and C reactive protein.	Phosphatidylcholines	32-51	C-reactive protein	Homo sapiens	123-141
19431774-1	1990	PYRENE FLUORESCENCE QUENCHING BY PLASTOQUINONE WAS USED TO ESTIMATE THE RATE OF PLASTOQUINONE LATERAL DIFFUSION IN SOYBEAN PHOSPHATIDYLCHOLINE PROTEOLIPOSOMES CONTAINING THE FOLLOWING INTEGRAL MEMBRANE PROTEINS: gramicidin D, spinach cytochrome bf complex, spinach cytochrome f, reaction centers from Rhodobacter sphaeroides, beef heart mitochondrial cytochrome bc(1), and beef heart mitochondrial cytochrome oxidase.	Phosphatidylcholines	123-142	apocytochrome f precursor	Spinacia oleracea	265-277
2280670-2	1990	Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called sterol carrier protein), enhanced the initial rate of sterol exchange between neutral zwitterionic phosphatidylcholine small unilamellar vesicles (SUV) 2.3-fold.	Phosphatidylcholines	234-253	sterol carrier protein 2	Homo sapiens	0-24
2280671-0	1990	Vasopressin stimulates phospholipase D activity against phosphatidylcholine in vascular smooth muscle cells.	Phosphatidylcholines	56-75	arginine vasopressin	Homo sapiens	0-11
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylcholines	107-126	coagulation factor III, tissue factor	Homo sapiens	72-74
2280671-2	1990	We have investigated the production of diacylglycerol from nonphosphoinositide sources, and we demonstrated that vasopressin and other vasoactive agents stimulate hydrolysis of phosphatidylcholine in a variety of cultured vascular smooth muscle cells of rat and human origin.	Phosphatidylcholines	177-196	arginine vasopressin	Rattus norvegicus	113-124
2280670-2	1990	Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called sterol carrier protein), enhanced the initial rate of sterol exchange between neutral zwitterionic phosphatidylcholine small unilamellar vesicles (SUV) 2.3-fold.	Phosphatidylcholines	234-253	sterol carrier protein 2	Homo sapiens	26-30
2280671-3	1990	We used vasopressin to characterize this response and found that vasopressin stimulates phospholipase D activity against phosphatidylcholine in A-10 vascular smooth muscle cells.	Phosphatidylcholines	121-140	arginine vasopressin	Homo sapiens	65-76
2280671-4	1990	The vasopressin-stimulated phosphatidylcholine hydrolysis is both time- and concentration-dependent.	Phosphatidylcholines	27-46	arginine vasopressin	Homo sapiens	4-15
2280671-5	1990	The half-maximal dose of vasopressin required for phosphatidylcholine hydrolysis (ED50 approximately 1 nM) correlates well with vasopressin binding to A-10 cells (Kd approximately 2 nM).	Phosphatidylcholines	50-69	arginine vasopressin	Homo sapiens	25-36
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylcholines	128-130	coagulation factor X	Homo sapiens	53-56
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylcholines	128-130	coagulation factor III, tissue factor	Homo sapiens	72-74
2170380-4	1990	Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity.	Phosphatidylcholines	99-101	arginine vasopressin	Rattus norvegicus	25-27
2280671-5	1990	The half-maximal dose of vasopressin required for phosphatidylcholine hydrolysis (ED50 approximately 1 nM) correlates well with vasopressin binding to A-10 cells (Kd approximately 2 nM).	Phosphatidylcholines	50-69	arginine vasopressin	Homo sapiens	128-139
2280671-6	1990	The phosphatidylcholine in A-10 cells can be preferentially radiolabeled with [3H]myristic acid; subsequent treatment with vasopressin stimulates a rapid increase in 3H-labeled phosphatidate (approximately 4 X control values at 3 min), and after a short lag, 3H-labeled diacylglycerol rises and reaches maximal levels at 10 min (approximately 2 X control values).	Phosphatidylcholines	4-23	arginine vasopressin	Homo sapiens	123-134
2280671-11	1990	The data indicate that vasopressin stimulates phospholipase D which hydrolyzes phosphatidylcholine to phosphatidate.	Phosphatidylcholines	79-98	arginine vasopressin	Homo sapiens	23-34
2170380-0	1990	Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts.	Phosphatidylcholines	45-64	arginine vasopressin	Rattus norvegicus	0-11
2170380-6	1990	In cells prelabeled with [3H]myristic acid, which is predominantly incorporated into cellular PC, VP elicited the generation of [3H]myristoyl phosphatidate (PA) as early as 15 s, in the absence of an increase in labeled DG.	Phosphatidylcholines	94-96	arginine vasopressin	Rattus norvegicus	98-100
2170380-4	1990	Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity.	Phosphatidylcholines	78-97	arginine vasopressin	Rattus norvegicus	25-27
2120207-12	1990	These results indicate that, in primed competent Balb/c 3T3 cells, IGF-I stimulates 1,2-DAG production via multiple pathways and that IGF-I may induce breakdown of phosphatidylcholine by a mechanism involving protein kinase C.	Phosphatidylcholines	164-183	insulin-like growth factor 1	Mus musculus	134-139
2266956-10	1990	Equilibration of PADPH between L-FABP and phosphatidylcholine (PC) bilayers resulted in a molar partition preference of greater than 20: 1, L-FABP PC.	Phosphatidylcholines	42-61	fatty acid binding protein 1	Homo sapiens	140-146
2266956-10	1990	Equilibration of PADPH between L-FABP and phosphatidylcholine (PC) bilayers resulted in a molar partition preference of greater than 20: 1, L-FABP PC.	Phosphatidylcholines	63-65	fatty acid binding protein 1	Homo sapiens	140-146
2222467-5	1990	It is possible that SAT-1 activation involves the structurally similar hydrophobic moieties and quaternary amino groups of LDAO and phosphatidylcholine.	Phosphatidylcholines	132-151	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	20-25
2223864-2	1990	The hydrolysis of phosphatidylcholine in vitro catalyzed by porcine pancreatic PLA2 was inhibited by heparin.	Phosphatidylcholines	18-37	phospholipase A2 group IB	Homo sapiens	79-83
2223865-4	1990	Despite these observations, in view of the putative role of microsomal phospholipase A2 in remodelling phosphatidylcholines for pulmonary surfactant biosynthesis, the purification of phospholipase A2 from microsomal membranes was investigated.	Phosphatidylcholines	103-123	phospholipase A2	Oryctolagus cuniculus	71-87
2079600-7	1990	When HDL3 was added to the culture medium, a two- to threefold increase in phosphatidylcholine synthesis and a twofold increase in sphingomyelin formation was observed after 3 h. Ca2+ antagonists of the dihydropyridine type, which down-regulate HDL-receptor activity and promote the formation and cellular release of lamellar bodies derived from the lysosomal compartment (Schmitz, G., et al.	Phosphatidylcholines	75-94	high density lipoprotein (HDL) level 3	Mus musculus	5-9
1979609-11	1990	Pf of endosomes containing the VP-sensitive water channel decreased fourfold by increasing membrane fluidity with hexanol or chloroform (0-75 mM); Pf of phosphatidylcholine liposomes (0.002 cm/s) increased 2.5-fold under the same conditions.	Phosphatidylcholines	153-172	arginine vasopressin	Homo sapiens	31-33
2175955-0	1990	Phosphatidylcholine breakdown in HDL3 stimulated platelets.	Phosphatidylcholines	0-19	HDL3	Homo sapiens	33-37
2271538-2	1990	Both the phosphatidylcholine transfer protein (PC-TP) and the phosphatidylinositol transfer protein (PI-TP) act as carriers of phosphatidylcholine (PC) molecules between membranes.	Phosphatidylcholines	9-28	phosphatidylcholine transfer protein	Bos taurus	47-52
2271538-2	1990	Both the phosphatidylcholine transfer protein (PC-TP) and the phosphatidylinositol transfer protein (PI-TP) act as carriers of phosphatidylcholine (PC) molecules between membranes.	Phosphatidylcholines	47-49	phosphatidylcholine transfer protein	Bos taurus	9-45
2171663-10	1990	The nsLTP also mediates an approximately equal rate of exchange of cholesterol and phosphatidylcholine.	Phosphatidylcholines	83-102	sterol carrier protein 2	Homo sapiens	4-9
2175955-1	1990	Low concentrations of HDL3 stimulate a transient biphasic increase in 1,2-diacylglycerol (DAG), with an early phase peaking at 30 seconds and a late phase at 60 seconds in (3H)-phosphatidylcholine prelabelled platelets.	Phosphatidylcholines	177-196	HDL3	Homo sapiens	22-26
2252906-1	1990	The techniques of ultrafast freezing and freeze-etch electron microscopy have been successfully employed to visualize IgG molecules and Fab fragments specifically bound to the neutral glycosphingolipids Forssman and asialo-GM1 incorporated into phosphatidylcholine liposomes.	Phosphatidylcholines	245-264	FA complementation group B	Homo sapiens	136-139
2201747-9	1990	The formation of PEt associated with a concomitant decrease in PdtOH directly demonstrated that the mechanism by which GM-CSF enhances PdtOH production is activation of a PLD active on phosphatidylcholine.	Phosphatidylcholines	185-204	colony stimulating factor 2	Homo sapiens	119-125
2201747-9	1990	The formation of PEt associated with a concomitant decrease in PdtOH directly demonstrated that the mechanism by which GM-CSF enhances PdtOH production is activation of a PLD active on phosphatidylcholine.	Phosphatidylcholines	185-204	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	171-174
2380172-1	1990	Self- or concentration quenching of octadecylrhodamine B (C18-Rh) fluorescence increases linearly in egg phosphatidylcholine (PC) vesicles but exponentially in vesicles composed of egg PC:cholesterol, 1:1, as the probe concentration is raised to 10 mol%.	Phosphatidylcholines	105-124	Bardet-Biedl syndrome 9	Homo sapiens	58-61
1697768-8	1990	The interaction between the mAbs and the hydrophobic moieties of PC molecules was further studied by analyzing the effect of the mAbs on the activities of phospholipase A2 and phospholipase C. JE-1 inhibited both enzyme activities, while JE-8 inhibited only the phospholipase C activity, indicating that JE-1 interacts more thoroughly with the hydrophobic region of the PC molecule than JE-8 does.	Phosphatidylcholines	65-67	phospholipase A2 group IB	Homo sapiens	155-171
2250200-7	1990	Films containing PC with SPA were more expanded on a subphase containing calcium compared to a subphase with no calcium.	Phosphatidylcholines	17-19	surfactant protein A2	Homo sapiens	25-28
2380172-6	1990	Decreases in the steady-state polarization of C18-Rh fluorescence as its concentration is raised to 10 mol% indicate energy transfer with emission between probe molecules in PC and to a lesser extent in PC + cholesterol membranes.	Phosphatidylcholines	174-176	Bardet-Biedl syndrome 9	Homo sapiens	46-49
2196173-7	1990	Moreover, the results indicate that CSF-1 stimulation is associated with decreases in PC, but not in phosphatidylinositol (PI), levels.	Phosphatidylcholines	86-88	colony stimulating factor 1	Homo sapiens	36-41
2386798-7	1990	Additional experiments indicated that hydroperoxides of phosphatidylcholine, cholesterol and cholesteryl esters in low-density lipoprotein are also good substrates for PHGPX.	Phosphatidylcholines	56-75	glutathione peroxidase 4	Homo sapiens	168-173
2196173-9	1990	In contrast, CSF-1 stimulation was associated with increased hydrolysis of PC to phosphorylcholine and diacylglycerol (DAG) in both intact monocytes and cell-free assays.	Phosphatidylcholines	75-77	colony stimulating factor 1	Homo sapiens	13-18
2395001-3	1990	IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha.	Phosphatidylcholines	26-45	interferon alpha 1	Homo sapiens	0-9
2395001-3	1990	IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha.	Phosphatidylcholines	26-45	interferon alpha 1	Homo sapiens	182-191
2395001-3	1990	IFN-alpha encapsulated in phosphatidylcholine/phosphatidylserine multilamellar vesicles produced growth inhibition of 67%, which was significantly greater than that produced by free IFN-alpha or by control liposomes containing only medium combined with free IFN-alpha.	Phosphatidylcholines	26-45	interferon alpha 1	Homo sapiens	182-191
2164068-8	1990	Our data indicate that phosphatidylcholine metabolism may be involved in IFN-gamma-regulated DAG accumulation.	Phosphatidylcholines	23-42	interferon gamma	Mus musculus	73-82
1699142-0	1990	An analysis of the regions of the myelin basic protein that bind to phosphatidylcholine.	Phosphatidylcholines	68-87	myelin basic protein	Mus musculus	34-54
1699142-1	1990	The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined.	Phosphatidylcholines	20-39	myelin basic protein	Mus musculus	63-83
1699142-1	1990	The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined.	Phosphatidylcholines	20-39	myelin basic protein	Mus musculus	85-88
1699142-1	1990	The interactions of phosphatidylcholine (PC) to regions of the myelin basic protein (MBP) was examined.	Phosphatidylcholines	41-43	myelin basic protein	Mus musculus	63-83
1699142-2	1990	In solid phase binding assays the nature of the binding of unilamellar vesicles of 14C-labeled phosphatidylcholine to bovine 18.5 kDa MBP, its N- and C-terminal peptide fragments, photooxidized 18.5 kDa MBP and the mouse 14 kDa protein, with an internal deletion of residues 117-157, was studied.	Phosphatidylcholines	95-114	myelin basic protein	Bos taurus	134-137
1699142-6	1990	The studies indicated that the sites of PC interaction with MBP are located in the N-terminal region of the protein.	Phosphatidylcholines	40-42	myelin basic protein	Mus musculus	60-63
2166941-0	1990	Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis.	Phosphatidylcholines	115-134	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	36-76
2166941-1	1990	CTP:phosphocholine cytidylyltransferase (EC 2.7.7.15) is a key regulatory enzyme in the synthesis of phosphatidylcholine in higher eukaryotes.	Phosphatidylcholines	101-120	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-39
2159807-7	1990	A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels.	Phosphatidylcholines	75-94	spindlin 1	Homo sapiens	152-156
2386385-6	1990	There were, however, lower concentrations of phosphatidylcholine and phosphatidylcholine palmitate content in infants colonised by organisms with reported phospholipase A2 activity.	Phosphatidylcholines	45-64	phospholipase A2 group IB	Homo sapiens	155-171
2358751-0	1990	Lipopolysaccharide (LPS) alters phosphatidylcholine metabolism in elicited peritoneal macrophages.	Phosphatidylcholines	32-51	toll-like receptor 4	Mus musculus	20-23
2188971-0	1990	Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene.	Phosphatidylcholines	42-61	KRAS proto-oncogene, GTPase	Homo sapiens	76-82
2188971-4	1990	Here we use a mutant of Ki-ras which is temperature-sensitive for transformation to investigate the kinetics of activation of the phosphodiesterase-mediated turnover of phosphatidylcholine.	Phosphatidylcholines	169-188	KRAS proto-oncogene, GTPase	Homo sapiens	24-30
2248600-6	1990	In studies with human fetal lung in organ culture, we have observed that glucocorticoids, in combination with prolactin and/or insulin, increase the rate of lamellar body phosphatidylcholine synthesis and alter lamellar body glycerophospholipid composition to one reflective of surfactant secreted by the human fetal lung at term.	Phosphatidylcholines	171-190	insulin	Homo sapiens	127-134
2116167-2	1990	Kinetic analyses showed a marked increase in the affinity of t-PA for Lys-plasminogen in the presence of heparin-inserted phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	122-141	plasminogen activator, tissue type	Homo sapiens	61-65
2116167-2	1990	Kinetic analyses showed a marked increase in the affinity of t-PA for Lys-plasminogen in the presence of heparin-inserted phosphatidylcholine (PC) liposomes.	Phosphatidylcholines	143-145	plasminogen activator, tissue type	Homo sapiens	61-65
2335511-6	1990	Using measurements of radiolabeled headgroup release and molecular species analysis, we previously determined that alpha-thrombin generates diglycerides through the hydrolysis of both the phosphoinositides and phosphatidylcholine at early times (15 s), and at later times (greater than or equal to 5 min) through the hydrolysis of primarily, if not exclusively, phosphatidylcholine (Pessin, M. S., and Raben, D. M. (1989) J. Biol.	Phosphatidylcholines	210-229	coagulation factor II, thrombin	Homo sapiens	121-129
2335511-6	1990	Using measurements of radiolabeled headgroup release and molecular species analysis, we previously determined that alpha-thrombin generates diglycerides through the hydrolysis of both the phosphoinositides and phosphatidylcholine at early times (15 s), and at later times (greater than or equal to 5 min) through the hydrolysis of primarily, if not exclusively, phosphatidylcholine (Pessin, M. S., and Raben, D. M. (1989) J. Biol.	Phosphatidylcholines	362-381	coagulation factor II, thrombin	Homo sapiens	121-129
2163209-9	1990	Although phorbol ester and bradykinin stimulated phosphatidylcholine turnover, isoproterenol did not.	Phosphatidylcholines	49-68	kininogen 1	Homo sapiens	27-37
2373243-0	1990	Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism.	Phosphatidylcholines	54-73	gastrin releasing peptide	Homo sapiens	0-8
2126577-1	1990	The phosphatidylethanolamine (PE) N-methyltransferase (MT) system is known to convert PE to phosphatidylcholine by three successive N-methylations.	Phosphatidylcholines	92-111	phosphatidylethanolamine N-methyltransferase	Mus musculus	4-53
2344437-1	1990	Diacylglycerol was generated in phosphatidylcholine vesicles by incubation with Clostridium welchii phospholipase C. Newly formed diacylglycerol was rapidly converted to monoacylglycerol and glycerol when rat liver cytosol fraction was present in the incubation mixture, suggesting the presence of di- and monoacylglycerol lipase activities in this subcellular fraction.	Phosphatidylcholines	32-51	monoglyceride lipase	Rattus norvegicus	306-329
2344437-2	1990	On the other hand, 3H-labeled diacylglycerol co-emulsified with non-radioactive phosphatidylcholine was found to be a poor substrate for the diacylglycerol lipase.	Phosphatidylcholines	80-99	lipase G, endothelial type	Rattus norvegicus	156-162
2335517-2	1990	Binding of apo-A-IV to egg phosphatidylcholine vesicles was rapid and did not cause release of encapsulated 6-carboxyfluorescein.	Phosphatidylcholines	27-46	apolipoprotein A4	Homo sapiens	11-19
2159807-7	1990	A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels.	Phosphatidylcholines	281-300	spindlin 1	Homo sapiens	110-114
2159807-7	1990	A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels.	Phosphatidylcholines	281-300	spindlin 1	Homo sapiens	152-156
2159807-7	1990	A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels.	Phosphatidylcholines	281-300	spindlin 1	Homo sapiens	152-156
2159807-7	1990	A comparison of the apparent order parameters and polarity profiles of the phosphatidylcholine and fatty acid spin labels indicates that the fatty acid spin labels are intercalated approximately one CH2 unit more deeply in the hydrocarbon region than are the positionally isomeric phosphatidylcholine spin labels.	Phosphatidylcholines	75-94	spindlin 1	Homo sapiens	152-156
2339422-2	1990	After 5 days of ACR administration (50 mg/kg/day) an increase in the incorporation of 32P into phosphatidylinositol-4,5-bisphosphate, phosphatidylinositol-4-phosphate, and phosphatidylcholine was detected in proximal sciatic nerve segments.	Phosphatidylcholines	172-191	acrosin	Rattus norvegicus	16-19
2373740-5	1990	In accordance with this, C-CAM was effectively incorporated into phosphatidylcholine liposomes by dialysis from octylglucoside-containing solutions.	Phosphatidylcholines	65-84	CEA cell adhesion molecule 1	Rattus norvegicus	25-30
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidylcholines	189-208	interleukin 1 alpha	Homo sapiens	29-39
2340304-6	1990	Results with human platelet cytosol were highly suggestive for the presence of an arachidonoyl-selective phospholipase A2 when separate phosphatidylcholine species were assayed.	Phosphatidylcholines	136-155	phospholipase A2 group IB	Homo sapiens	105-121
1693743-1	1990	Enzymatically active, detergent-solubilized purified hormone-sensitive lipase (HSL) was incorporated into phosphatidylcholine (PC) vesicles, using a detergent-dialysis procedure with small PC vesicles, obtained by sonication, as phospholipid source and CHAPS, a zwitterionic bile-salt derivative, as detergent.	Phosphatidylcholines	106-125	lipase E, hormone sensitive type	Homo sapiens	53-77
1693743-1	1990	Enzymatically active, detergent-solubilized purified hormone-sensitive lipase (HSL) was incorporated into phosphatidylcholine (PC) vesicles, using a detergent-dialysis procedure with small PC vesicles, obtained by sonication, as phospholipid source and CHAPS, a zwitterionic bile-salt derivative, as detergent.	Phosphatidylcholines	106-125	lipase E, hormone sensitive type	Homo sapiens	79-82
2337575-4	1990	PC/PS mixtures show a pronounced tendency to form metastable solutions in the presence of calcium, particularly when they contain less than equimolar proportions of PS.	Phosphatidylcholines	0-2	surfactant protein C	Homo sapiens	3-5
2322573-4	1990	HDL subfractions were then treated with or without phospholipase A2 from Crotalus adamanteus in presence of albumin leading to a 72-82% phosphatidylcholine degradation.	Phosphatidylcholines	136-155	phospholipase A2 group IB	Homo sapiens	51-67
2159287-6	1990	Studies of phospholipid metabolism strongly suggested that phosphatidylcholine was the source of the 1,2-diacylglycerol generated in response to EGF.	Phosphatidylcholines	59-78	epidermal growth factor	Homo sapiens	145-148
2159287-8	1990	This pattern of sustained 1,2-diacylglycerol formation from phosphatidylcholine may be important in the mitogenic signalling of EGF and potentially other growth factors.	Phosphatidylcholines	60-79	epidermal growth factor	Homo sapiens	128-131
2159335-6	1990	By use of the same technique for model membranes, it was shown that in phosphatidylcholine bilayers the collision frequency of the three fluorescent phosphoinositides decreased in the order PI greater than PIP greater than PIP2.	Phosphatidylcholines	71-90	prolactin induced protein	Homo sapiens	206-209
2333953-1	1990	The phosphatidylcholine-specific transfer protein (PC-Tp) from bovine liver was used to replace endogeneous erythrocyte phosphatidylcholine (PC) with various amounts of five different molecular species of PC.	Phosphatidylcholines	4-23	phosphatidylcholine transfer protein	Bos taurus	51-56
2108726-1	1990	Lipid transfer between human plasma low-density lipoprotein (LDL) and an LDL-size microemulsion of triolein and phosphatidylcholine stabilized with human apolipoprotein A-I was catalyzed by the lipid transfer particle from hemolymph of the tobacco hornworm (Manduca sexta).	Phosphatidylcholines	112-131	apolipoprotein A1	Homo sapiens	154-172
2156839-0	1990	Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene.	Phosphatidylcholines	8-27	Harvey rat sarcoma virus oncogene	Mus musculus	79-89
2156839-1	1990	The effect of expression of the Harvey-ras oncogene on phosphatidylcholine metabolism in C3H10T1/2 mouse fibroblast cells was examined.	Phosphatidylcholines	55-74	Harvey rat sarcoma virus oncogene	Mus musculus	32-42
2138608-1	1990	Studies are reported on the inhibition of phospholipase A2 (PLA2) from porcine pancreas, cobra (Naja naja) venom, and the P388D1 macrophage-like cell line by human recombinant lipocortin I and bovine lung calpactin I. Membrane vesicles prepared from 1-stearoyl,2-arachidonoyl phosphatidylcholine (PC) and other PCs were utilized as substrate.	Phosphatidylcholines	297-299	phospholipase A2 group IB	Homo sapiens	42-58
2138608-1	1990	Studies are reported on the inhibition of phospholipase A2 (PLA2) from porcine pancreas, cobra (Naja naja) venom, and the P388D1 macrophage-like cell line by human recombinant lipocortin I and bovine lung calpactin I. Membrane vesicles prepared from 1-stearoyl,2-arachidonoyl phosphatidylcholine (PC) and other PCs were utilized as substrate.	Phosphatidylcholines	297-299	phospholipase A2 group IB	Homo sapiens	60-64
2139793-5	1990	The tryptophan fluorescence of bound lipocortin I was nearly unaffected by substituting the quencher 1-palmitoyl-2-(5-doxylstearoyl)-sn-glycero-3-phosphocholine (5-PC) for egg phosphatidylcholine, while that of the lipocortin V tryptophan was quenched significantly.	Phosphatidylcholines	176-195	annexin A1	Bos taurus	37-49
2158306-1	1990	Previous studies showed that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells [Kolesnick (1987) J. Biol.	Phosphatidylcholines	95-114	thyrotropin releasing hormone	Rattus norvegicus	48-77
2358187-2	1990	Upon interaction of CaM with egg phosphatidylcholine and asolectin BLM the parameter E perpendicular grew slightly (not more than by 10% as compared to the respective vale for nonmodified BLM), suggesting a weak effect on the ordering of the hydrophobic moiety of the lipid bilayer.	Phosphatidylcholines	33-52	calmodulin 1	Homo sapiens	20-23
2140896-1	1990	Expression of functionally active bovine visual rhodopsin was achieved by sequential transcription and translation in vitro of rhodopsin gene cDNA with co-translational insertion of the protein into phosphatidylcholine liposomes.	Phosphatidylcholines	199-218	rhodopsin	Bos taurus	48-57
2337575-6	1990	Different PS species exhibit different apparent residual solubilities in liquid-crystalline PC bilayers, ranging from less than 10 mol % for dimyristoyl-PS to ca.	Phosphatidylcholines	92-94	surfactant protein C	Homo sapiens	10-12
2108162-3	1990	EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	139-158	epidermal growth factor like 1	Rattus norvegicus	0-3
2108162-3	1990	EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	139-158	phospholipase A2 group IB	Rattus norvegicus	13-17
2337575-4	1990	PC/PS mixtures show a pronounced tendency to form metastable solutions in the presence of calcium, particularly when they contain less than equimolar proportions of PS.	Phosphatidylcholines	0-2	surfactant protein C	Homo sapiens	165-167
2303476-2	1990	Equilibrium binding studies of prothrombinase complex formation were undertaken using phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine (PCPS), factor Va, and factor Xa modified with dansyl glutamylglycinylarginyl chloromethyl ketone (DEGR.Xa).	Phosphatidylcholines	120-139	coagulation factor X	Homo sapiens	31-45
2155238-2	1990	Mutations at the INO4 locus result in a decrease in phosphatidylcholine synthesis and an inability to derepress the structural genes for inositol-1-phosphate synthase and phosphatidylserine synthase.	Phosphatidylcholines	52-71	Ino4p	Saccharomyces cerevisiae S288C	17-21
2155224-0	1990	Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine.	Phosphatidylcholines	122-141	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	23-62
1968928-4	1990	This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates.	Phosphatidylcholines	92-111	phospholipase A2 group IB	Homo sapiens	75-79
1968928-4	1990	This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates.	Phosphatidylcholines	92-111	phospholipase A2 group IB	Homo sapiens	280-284
1968928-4	1990	This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates.	Phosphatidylcholines	92-111	phospholipase A2 group IB	Homo sapiens	280-284
1968928-4	1990	This release is largely independent of PLC activation and is mediated by a PLA2 because: 1) phosphatidylcholine is the preferential source of [3H]arachidonate release; 2) [3H]arachidonic acid release and phosphatidylcholine hydrolysis are blocked by two inhibitors of solubilized PLA2, mepacrine, and 4-p-bromophenacylbromide; and 3) we evidenced a PLA2 activity in cell homogenates.	Phosphatidylcholines	204-223	phospholipase A2 group IB	Homo sapiens	75-79
2155032-1	1990	The effects of cholesterol on the dynamics of cholestane spin probe (CSL) in various phosphatidylcholine-cholesterol mixed model membranes are examined.	Phosphatidylcholines	85-104	chorionic somatomammotropin hormone like 1	Homo sapiens	69-72
2357235-3	1990	Functional expression of bovine visual rhodopsin in the cell-free translation system with cotranslational insertion of the protein into phosphatidylcholine liposomes is described.	Phosphatidylcholines	136-155	rhodopsin	Bos taurus	39-48
2317195-0	1990	P2-purinoceptor regulation of surfactant phosphatidylcholine secretion.	Phosphatidylcholines	41-60	pyrimidinergic receptor P2Y6	Homo sapiens	0-15
2155031-0	1990	Stimulation of CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis by incubation of rat hepatocytes with phospholipase A2.	Phosphatidylcholines	60-79	phospholipase A2 group IB	Rattus norvegicus	128-144
2317195-11	1990	These results are consistent with a prominent role for protein kinase C in regulation of P2-purinoceptor-induced surfactant phosphatidylcholine secretion, and indicate that Ca2+ mobilization is not a necessary step for ATP-induced surfactant phosphatidylcholine secretion.	Phosphatidylcholines	124-143	pyrimidinergic receptor P2Y6	Homo sapiens	89-104
2135667-7	1990	In [3H]ethanolamine-prelabeled cells, but not in [3H]choline-prelabeled cells, PHA, CD3 and CD2 induced the breakdown of PC.	Phosphatidylcholines	121-123	CD2 molecule	Homo sapiens	92-95
2155031-1	1990	The effect of phospholipase A2 treatment of rat hepatocytes on CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis was investigated.	Phosphatidylcholines	108-127	phospholipase A2 group IB	Rattus norvegicus	14-30
2155031-7	1990	Incubation of hepatocytes in the presence of phospholipase A2 (0.9 units/dish) for 10 min prior to pulse-chase experiments resulted in an increase in radiolabel incorporation into phosphatidylcholine (from 2.4 +/- 0.02.10(-5) dpm/dish to 3.1 +/- 0.1.10(-5) dpm/dish) and a corresponding decrease in radiolabel associated with the choline (from 2.5 +/- 0.05.10(-5) to 1.4 +/- 0.03.10(-5) dpm) and phosphocholine fractions (from 8.5 +/- 0.07.10(-5) to 6.9 +/- 0.05.10(-5) dpm).	Phosphatidylcholines	180-199	phospholipase A2 group IB	Rattus norvegicus	45-61
2155031-8	1990	We conclude that phospholipase A2 can cause a stimulation of CTP: phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in cultured rat hepatocytes.	Phosphatidylcholines	115-134	phospholipase A2 group IB	Rattus norvegicus	17-33
2111711-6	1990	Based upon these results, we also conclude that the combined hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 serves as a major source for eicosanoid biosynthesis in thrombin-stimulated human platelets.	Phosphatidylcholines	75-94	phospholipase A2 group IB	Homo sapiens	123-139
2105749-0	1990	Interaction of apolipoprotein A-II with recombinant HDL containing egg phosphatidylcholine, unesterified cholesterol and apolipoprotein A-I.	Phosphatidylcholines	71-90	apolipoprotein A1	Homo sapiens	15-33
2305899-10	1990	We suggest that adenosine deaminase stimulates phosphatidylcholine secretion by removing adenosine that occupies A1 receptors, thus reversing inhibition of cAMP-mediated secretion.	Phosphatidylcholines	47-66	adenosine deaminase	Rattus norvegicus	16-35
2102782-0	1990	Effect of prolactin on phosphatidylcholine hydrolysis via phospholipase C in isolated adrenocortical cells of guinea pig.	Phosphatidylcholines	23-42	prolactin	Cavia porcellus	10-19
2301861-6	1990	Female fetal rat lung tissue exposed to recombinant MIS (10(-9) M, 10(-8) M) revealed depressed disaturated phosphatidylcholine content both 48 and 72 h after injection compared with female vehicle-injected littermates.	Phosphatidylcholines	108-127	anti-Mullerian hormone	Rattus norvegicus	52-55
2111711-6	1990	Based upon these results, we also conclude that the combined hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A2 serves as a major source for eicosanoid biosynthesis in thrombin-stimulated human platelets.	Phosphatidylcholines	75-94	coagulation factor II, thrombin	Homo sapiens	196-204
2305210-3	1990	The influence of bile salts was thus similar to that which has earlier been described for the hydrolysis of phosphatidylcholine (PC) with pig pancreatic phospholipase A2.	Phosphatidylcholines	108-127	phospholipase A2 group IB	Homo sapiens	153-169
2305210-3	1990	The influence of bile salts was thus similar to that which has earlier been described for the hydrolysis of phosphatidylcholine (PC) with pig pancreatic phospholipase A2.	Phosphatidylcholines	129-131	phospholipase A2 group IB	Homo sapiens	153-169
2298300-3	1990	These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous 31P NMR studies) and histological modifications demonstrated that at early stages of TNF-induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products.	Phosphatidylcholines	411-430	tumor necrosis factor	Mus musculus	229-232
2154211-2	1990	PAF ranging in concentration from 10(-6)-10(-9)M initiated the incorporation of 32P into phosphatidic acid (PA) and phosphatidylinositol (PI) with no change in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) over baseline.	Phosphatidylcholines	194-213	PCNA clamp associated factor	Homo sapiens	0-3
2350485-3	1990	From 3 to 17 mol% of phosphatidylcholine, selectively deuterated at various positions along the sn-2-acyl chain, was transferred from unilamellar vesicles to VLDL using a partially purified phosphatidylcholine transfer protein.	Phosphatidylcholines	21-40	CD320 antigen	Mus musculus	158-162
2154211-2	1990	PAF ranging in concentration from 10(-6)-10(-9)M initiated the incorporation of 32P into phosphatidic acid (PA) and phosphatidylinositol (PI) with no change in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) over baseline.	Phosphatidylcholines	215-217	PCNA clamp associated factor	Homo sapiens	0-3
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	Phosphatidylcholines	24-43	cut-like homeobox 1	Rattus norvegicus	85-88
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	Phosphatidylcholines	24-43	cut-like homeobox 1	Rattus norvegicus	177-180
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	Phosphatidylcholines	123-142	cut-like homeobox 1	Rattus norvegicus	85-88
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	Phosphatidylcholines	123-142	cut-like homeobox 1	Rattus norvegicus	177-180
2153111-3	1990	In the presence of phosphatidylcholine transfer protein, the incorporation of CDP-choline into phosphatidylcholine was markedly stimulated.	Phosphatidylcholines	19-38	cut-like homeobox 1	Rattus norvegicus	78-81
2105091-5	1990	This is the first time a peptide activator for LCAT that rivals the activity of apo A-I in the vesicular and discoidal egg phosphatidylcholine assay systems has been synthesized.	Phosphatidylcholines	123-142	lecithin-cholesterol acyltransferase	Homo sapiens	47-51
2105091-5	1990	This is the first time a peptide activator for LCAT that rivals the activity of apo A-I in the vesicular and discoidal egg phosphatidylcholine assay systems has been synthesized.	Phosphatidylcholines	123-142	apolipoprotein A1	Homo sapiens	80-87
2129785-4	1990	Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures.	Phosphatidylcholines	129-149	interleukin 1 beta	Rattus norvegicus	17-27
2350485-3	1990	From 3 to 17 mol% of phosphatidylcholine, selectively deuterated at various positions along the sn-2-acyl chain, was transferred from unilamellar vesicles to VLDL using a partially purified phosphatidylcholine transfer protein.	Phosphatidylcholines	190-209	CD320 antigen	Mus musculus	158-162
33794068-7	2021	Moreover, in the absence of SMAC/Diablo, PSD inhibited cancer cell proliferation by catalysing the overproduction of mitochondrial PE and depleting the cellular levels of PC, PE and PS.	Phosphatidylcholines	171-173	F-box and leucine rich repeat protein 15	Homo sapiens	41-44
2369553-1	1990	We determined whether transforming growth factor-beta 1 (TGF-beta 1) encapsulated in phosphatidylcholine and phosphatidylserine liposomes could inhibit the proliferative response of mouse liver subsequent to partial hepatectomy.	Phosphatidylcholines	85-104	transforming growth factor, beta 1	Mus musculus	22-55
2369553-1	1990	We determined whether transforming growth factor-beta 1 (TGF-beta 1) encapsulated in phosphatidylcholine and phosphatidylserine liposomes could inhibit the proliferative response of mouse liver subsequent to partial hepatectomy.	Phosphatidylcholines	85-104	transforming growth factor, beta 1	Mus musculus	57-67
2110108-1	1990	The role of NADPH--cytochrome P450 reductase and cytochrome P450 in NADPH- and ADP--Fe3(+)-dependent lipid peroxidation was investigated by using the purified enzymes and liposomes prepared from either total rat-liver phospholipids or a mixture of bovine phosphatidyl choline and phosphatidyl ethanolamine (PC/PE liposomes).	Phosphatidylcholines	255-275	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-34
33794068-6	2021	As a result, PSD activity and mitochondrial PE levels were increased in the mitochondria of SMAC/Diablo-deficient cancer cells, with the total amount of cellular phospholipids and phosphatidylcholine (PC) being lower as compared to SMAC-expressing cancer cells.	Phosphatidylcholines	180-199	diablo IAP-binding mitochondrial protein	Homo sapiens	92-96
2073400-2	1990	A novel method for determination of PLA2 activity in intact cell membranes with a fluorescent analogue of phosphatidylcholine, was employed.	Phosphatidylcholines	106-125	phospholipase A2 group IIA	Homo sapiens	36-40
2307391-2	1990	Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours.	Phosphatidylcholines	113-133	prolactin	Mus musculus	40-43
2307391-2	1990	Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours.	Phosphatidylcholines	135-137	prolactin	Mus musculus	40-43
2402761-7	1990	The melittin-stimulated PLA2 activity observed in cells was primarily associated with phosphatidylcholine.	Phosphatidylcholines	86-105	phospholipase A2 group IB	Homo sapiens	24-28
3233222-3	1988	Membranes composed of a mixture of phosphatidylcholine (PC) and positively charged lipids like stearylamine, sphingosine, or hexadecyltrimethylammonium bromide caused a more than 1000-fold increase of the rate of prothrombin activation.	Phosphatidylcholines	35-54	coagulation factor II, thrombin	Homo sapiens	213-224
3233222-3	1988	Membranes composed of a mixture of phosphatidylcholine (PC) and positively charged lipids like stearylamine, sphingosine, or hexadecyltrimethylammonium bromide caused a more than 1000-fold increase of the rate of prothrombin activation.	Phosphatidylcholines	56-58	coagulation factor II, thrombin	Homo sapiens	213-224
3233222-7	1988	Calcium ions strongly inhibited prothrombin activation on vesicles composed of PC and stearylamine (80/20 M/M), which indicates that the regions of prothrombin and/or factor Xa containing gamma-carboxyglutamic acid (gla) are important for the interaction of these proteins with positively charged membranes.	Phosphatidylcholines	79-81	coagulation factor II, thrombin	Homo sapiens	32-43
33818269-11	2021	PNPLA6-related disorders are a phenotypically highly heterogenous group where alterations in the phosphatidylcholine metabolism can lead to manifestations in different tissues with no clear genotype-phenotype correlation.	Phosphatidylcholines	97-116	patatin like phospholipase domain containing 6	Homo sapiens	0-6
33794068-6	2021	As a result, PSD activity and mitochondrial PE levels were increased in the mitochondria of SMAC/Diablo-deficient cancer cells, with the total amount of cellular phospholipids and phosphatidylcholine (PC) being lower as compared to SMAC-expressing cancer cells.	Phosphatidylcholines	201-203	diablo IAP-binding mitochondrial protein	Homo sapiens	92-96
24777581-8	2014	On the other hand, the loss of HL, EL, or both raised the plasma concentrations for select molecular species of phosphatidylcholine, cholesteryl ester, diacylglycerol, sphingomyelin, ceramide, plasmanylcholine, and plasmenylcholine.	Phosphatidylcholines	112-131	lipase, hepatic	Mus musculus	31-33
33809964-7	2021	By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine.	Phosphatidylcholines	209-228	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	17-62
33809964-7	2021	By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine.	Phosphatidylcholines	209-228	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	64-68
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	158-177	hemoglobin subunit gamma 2	Homo sapiens	44-57
20705608-3	2010	Mouse cPLA(2)beta action on phosphatidylcholine vesicles is activated by anionic phosphoinositides and cardiolipin but displays a requirement for Ca(2+) only in the presence of cardiolipin.	Phosphatidylcholines	28-47	phospholipase A2, group IVB (cytosolic)	Mus musculus	6-17
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	158-177	cytochrome c, somatic	Homo sapiens	69-81
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	158-177	cytochrome c, somatic	Homo sapiens	83-88
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	179-181	hemoglobin subunit gamma 2	Homo sapiens	44-57
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	179-181	cytochrome c, somatic	Homo sapiens	69-81
19513819-2	2009	Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL).	Phosphatidylcholines	179-181	cytochrome c, somatic	Homo sapiens	83-88
19517528-5	2009	Newly synthesized PC by PEMT2 contained more acyl groups of oleic acid (P &lt; 0.01) and was mainly located in mitochondria; pemt2 over-expression increased the mitochondrial membrane fluidity and the release of cytochrome C from the mitochondria into the cytoplasma, which in turn activated caspase-9 and caspase-3, the key molecules in the mitochondrial apoptotic pathway.	Phosphatidylcholines	18-20	caspase 9	Rattus norvegicus	292-301
19517528-5	2009	Newly synthesized PC by PEMT2 contained more acyl groups of oleic acid (P &lt; 0.01) and was mainly located in mitochondria; pemt2 over-expression increased the mitochondrial membrane fluidity and the release of cytochrome C from the mitochondria into the cytoplasma, which in turn activated caspase-9 and caspase-3, the key molecules in the mitochondrial apoptotic pathway.	Phosphatidylcholines	18-20	caspase 3	Rattus norvegicus	306-315
34866326-3	2022	Here, we perform quantitative phosphoproteomics and phospholipid analysis and find that PfCDPK7 promotes phosphatidylcholine (PC) synthesis by regulating two key enzymes involved in PC synthesis, phosphoethanolamine-N-methyltransferase (PMT) and ethanolamine kinase (EK).	Phosphatidylcholines	105-124	choline kinase alpha	Homo sapiens	246-265
10330032-7	1999	The MBP-induced increase in PC secretion was significantly reduced by preadministration of either H-7, a protein kinase inhibitor, or 1, 2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-AM, a chelator of intracellular Ca2+, but not by H-89, a protein kinase inhibitor.	Phosphatidylcholines	28-30	myelin basic protein	Rattus norvegicus	4-7
10330032-8	1999	Our results suggest that the MBP-induced increase in PC secretion may provide mechanical stability and protect against lung atelectasis.	Phosphatidylcholines	53-55	myelin basic protein	Rattus norvegicus	29-32
34944757-4	2021	METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI).	Phosphatidylcholines	204-223	low density lipoprotein receptor	Homo sapiens	27-29
34944757-4	2021	METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI).	Phosphatidylcholines	204-223	low density lipoprotein receptor	Homo sapiens	94-106
34944757-4	2021	METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI).	Phosphatidylcholines	225-227	low density lipoprotein receptor	Homo sapiens	27-29
34944757-4	2021	METHODS AND RESULTS: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI).	Phosphatidylcholines	225-227	low density lipoprotein receptor	Homo sapiens	94-106
34808333-5	2022	Lipidomic analysis showed that FOXM1 increased unsaturated triglyceride (TG) and phosphatidylcholine (PC) abundance, which are the main components of lipid droplet (LD).	Phosphatidylcholines	81-100	forkhead box M1	Mus musculus	31-36
34808333-5	2022	Lipidomic analysis showed that FOXM1 increased unsaturated triglyceride (TG) and phosphatidylcholine (PC) abundance, which are the main components of lipid droplet (LD).	Phosphatidylcholines	102-104	forkhead box M1	Mus musculus	31-36
34846128-7	2021	The binding of PI(4,5)P2 modified with a fluorophore to Kir3.2 can be enhanced by other lipids, such as phosphatidylcholine.	Phosphatidylcholines	104-123	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	56-62
34929484-5	2022	Amino acid sequence segmentation analysis indicated that the K-segment of AtHIRD11 inhibited the cryoaggregation of phosphatidylcholine (PC) liposomes but other segments did not.	Phosphatidylcholines	116-135	dehydrin family protein	Arabidopsis thaliana	74-82
34929484-5	2022	Amino acid sequence segmentation analysis indicated that the K-segment of AtHIRD11 inhibited the cryoaggregation of phosphatidylcholine (PC) liposomes but other segments did not.	Phosphatidylcholines	137-139	dehydrin family protein	Arabidopsis thaliana	74-82
34866326-3	2022	Here, we perform quantitative phosphoproteomics and phospholipid analysis and find that PfCDPK7 promotes phosphatidylcholine (PC) synthesis by regulating two key enzymes involved in PC synthesis, phosphoethanolamine-N-methyltransferase (PMT) and ethanolamine kinase (EK).	Phosphatidylcholines	126-128	choline kinase alpha	Homo sapiens	246-265
34849527-8	2021	Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	134-153	phosphatidylethanolamine N-methyltransferase	Homo sapiens	71-115
34419589-7	2021	Cellular phosphatidylcholine/phosphatidylethanolamine ratio was decreased only upon overexpression of the proteins, potentially contributing to altered ApoB100 assembly and secretion.	Phosphatidylcholines	9-28	apolipoprotein B	Homo sapiens	152-159
34774525-0	2021	Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity.	Phosphatidylcholines	40-59	sphingomyelin synthase 1	Mus musculus	0-31
34774525-3	2021	Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity.	Phosphatidylcholines	262-264	sphingomyelin synthase 1	Homo sapiens	141-145
34774525-3	2021	Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity.	Phosphatidylcholines	262-264	sphingomyelin synthase 2	Homo sapiens	150-154
34774525-3	2021	Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity.	Phosphatidylcholines	262-264	sphingomyelin synthase 1	Homo sapiens	292-296
34774525-3	2021	Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity.	Phosphatidylcholines	262-264	sphingomyelin synthase 2	Homo sapiens	301-305
34774525-7	2021	Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine.	Phosphatidylcholines	148-150	sphingomyelin synthase 1	Mus musculus	31-35
34774525-7	2021	Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine.	Phosphatidylcholines	148-150	sphingomyelin synthase 2	Homo sapiens	40-44
34774525-7	2021	Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine.	Phosphatidylcholines	148-150	sphingomyelin synthase 1	Mus musculus	120-124
34774525-7	2021	Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine.	Phosphatidylcholines	148-150	sphingomyelin synthase 2	Homo sapiens	129-133
34416390-2	2021	StarD7 is a lipid transport protein involved in the phosphatidylcholine (PC) delivery to mitochondria.	Phosphatidylcholines	52-71	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
34416390-2	2021	StarD7 is a lipid transport protein involved in the phosphatidylcholine (PC) delivery to mitochondria.	Phosphatidylcholines	73-75	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
34416390-6	2021	StarD7.I (D7.I) stable cells were able to transport higher fluorescent PC analog to mitochondria than Ct cells, yield mitochondrial fusions, maintained the membrane potential, and produced lower levels of reactive oxygen species (ROS).	Phosphatidylcholines	71-73	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
34322898-11	2021	Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2.	Phosphatidylcholines	104-123	peroxiredoxin 1	Mus musculus	26-31
34322898-11	2021	Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2.	Phosphatidylcholines	104-123	glycerophosphodiester phosphodiesterase domain containing 5	Mus musculus	90-95
34322898-11	2021	Moreover, the function of PRDX1 in the suppression of TRAF6 ubiquitin-ligase activity and GDPD5-related phosphatidylcholine metabolism were inhibited by GNAI2.	Phosphatidylcholines	104-123	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	153-158
34849527-8	2021	Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	134-153	phosphatidylethanolamine N-methyltransferase	Homo sapiens	117-121
34849527-8	2021	Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	155-157	phosphatidylethanolamine N-methyltransferase	Homo sapiens	71-115
34849527-8	2021	Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	155-157	phosphatidylethanolamine N-methyltransferase	Homo sapiens	117-121
34876384-6	2022	The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model.	Phosphatidylcholines	54-73	phospholipase D1	Homo sapiens	11-27
34778899-8	2021	GMCSFRbeta KO mice reproduced the histopathological and biochemical features of PAP, accumulating surfactant PC in both broncho-alveolar lavage fluid (BALF) and lavaged lung tissue.	Phosphatidylcholines	109-111	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	Mus musculus	0-10
34876384-6	2022	The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model.	Phosphatidylcholines	54-73	phospholipase D1	Homo sapiens	29-33
34748631-3	2022	Evaluating the association of correlations among metabolites and/or lipids with age, we found that phosphatidylcholines correlations tend to have a positive trend associated with age in women, and monoacylglycerols and lysophosphatidylcholines correlations tend to have a negative trend associated with age in men.	Phosphatidylcholines	99-119	renin binding protein	Homo sapiens	80-83
34772952-6	2021	Molecular dynamics simulations revealed that a Tyr-Pro molecule was stably positioned in the two potential binding pockets (sites 1 and 2) of the seven-transmembrane receptor, AdipoR1, anchored in a virtual 1-palmitoyl-2-oleoyl-phosphatidylcholine membrane.	Phosphatidylcholines	228-247	adiponectin receptor 1	Homo sapiens	176-183
34748631-3	2022	Evaluating the association of correlations among metabolites and/or lipids with age, we found that phosphatidylcholines correlations tend to have a positive trend associated with age in women, and monoacylglycerols and lysophosphatidylcholines correlations tend to have a negative trend associated with age in men.	Phosphatidylcholines	99-119	renin binding protein	Homo sapiens	179-182
34748631-4	2022	The association of ratio between molecular features with age reveals that the ratio between decanoyl L-carnitine and lysophosphatidylcholine in women have a negative association with age, while the ratios between L-carnitine, L-acetylcarnitine, and phosphatidylcholines in men have a positive association with age.	Phosphatidylcholines	249-269	renin binding protein	Homo sapiens	57-60
34748631-4	2022	The association of ratio between molecular features with age reveals that the ratio between decanoyl L-carnitine and lysophosphatidylcholine in women have a negative association with age, while the ratios between L-carnitine, L-acetylcarnitine, and phosphatidylcholines in men have a positive association with age.	Phosphatidylcholines	249-269	renin binding protein	Homo sapiens	310-313
34379812-7	2021	The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA.	Phosphatidylcholines	28-47	clasper	Mus musculus	13-16
34418535-1	2021	Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of phosphatidylcholine to ceramide in mammals.	Phosphatidylcholines	165-184	sphingomyelin synthase 1	Homo sapiens	63-67
34418535-1	2021	Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of phosphatidylcholine to ceramide in mammals.	Phosphatidylcholines	165-184	sphingomyelin synthase 2	Homo sapiens	72-76
34379812-7	2021	The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA.	Phosphatidylcholines	28-47	clasper	Mus musculus	49-52
34379812-7	2021	The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA.	Phosphatidylcholines	28-47	clasper	Mus musculus	106-109
34868703-0	2021	DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells.	Phosphatidylcholines	13-32	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
34686867-5	2021	Ablation of XBP1 expression with genetic manipulation or ameliorating ER stress responses by facilitating LPCAT3-mediated incorporation of unsaturated lipids to the phosphatidylcholine hampered pro-tumorigenic phenotype and survival in TAMs.	Phosphatidylcholines	165-184	X-box binding protein 1	Homo sapiens	12-16
34686867-5	2021	Ablation of XBP1 expression with genetic manipulation or ameliorating ER stress responses by facilitating LPCAT3-mediated incorporation of unsaturated lipids to the phosphatidylcholine hampered pro-tumorigenic phenotype and survival in TAMs.	Phosphatidylcholines	165-184	lysophosphatidylcholine acyltransferase 3	Homo sapiens	106-112
34868703-0	2021	DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells.	Phosphatidylcholines	13-32	kinase insert domain receptor	Homo sapiens	100-106
34868703-0	2021	DHA-enriched phosphatidylcholine suppressed angiogenesis by activating PPARgamma and modulating the VEGFR2/Ras/ERK pathway in human umbilical vein endothelial cells.	Phosphatidylcholines	13-32	mitogen-activated protein kinase 1	Homo sapiens	111-114
34684619-10	2021	CONCLUSIONS: The binding of aromatic acids to phosphatidylcholine increases their beneficial effect on insulin sensitivity in adipocytes and expands their potential practical application as nutraceutical health-promoting agents.	Phosphatidylcholines	46-65	insulin	Homo sapiens	103-110
34676404-7	2021	We propose that PMT1 and PMT2 are induced by P starvation to produce PCho mainly for leaf growth maintenance, rather than for phosphatidylcholine biosynthesis, in membrane lipid remodeling.	Phosphatidylcholines	126-145	polyol/monosaccharide transporter 2	Arabidopsis thaliana	25-29
34520050-3	2021	The requirement for PC is suppressed by monosomy of chromosome XV or by a point mutation in the ACC1 gene encoding acetyl-CoA carboxylase.	Phosphatidylcholines	20-22	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	96-100
34607314-9	2021	Phosphatidylcholines, cholesteryl ester, cholesterol, ceramide-1-phosphate, and CCL5 expression were significantly higher in aged WT mice than in aged Postn-null mice.	Phosphatidylcholines	0-20	periostin, osteoblast specific factor	Mus musculus	151-156
34107287-1	2021	ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs.	Phosphatidylcholines	104-123	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34107287-1	2021	ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs.	Phosphatidylcholines	125-127	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	tumor necrosis factor	Homo sapiens	102-129
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	tumor necrosis factor	Homo sapiens	131-140
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	C-reactive protein	Homo sapiens	143-161
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	C-reactive protein	Homo sapiens	163-166
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	interleukin 6	Homo sapiens	173-186
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	53-72	interleukin 6	Homo sapiens	188-192
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	74-76	tumor necrosis factor	Homo sapiens	102-129
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	74-76	tumor necrosis factor	Homo sapiens	131-140
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	74-76	C-reactive protein	Homo sapiens	143-161
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	74-76	C-reactive protein	Homo sapiens	163-166
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Phosphatidylcholines	74-76	interleukin 6	Homo sapiens	188-192
34607314-11	2021	Lysophosphatidylcholine acyltransferase 2, which converts lysophosphatidylcholine to phosphatidylcholine, was significantly higher in aged WT mice than in aged Postn-null mice.	Phosphatidylcholines	85-104	lysophosphatidylcholine acyltransferase 2	Mus musculus	0-41
34607314-11	2021	Lysophosphatidylcholine acyltransferase 2, which converts lysophosphatidylcholine to phosphatidylcholine, was significantly higher in aged WT mice than in aged Postn-null mice.	Phosphatidylcholines	85-104	periostin, osteoblast specific factor	Mus musculus	160-165
34197964-5	2021	Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine.	Phosphatidylcholines	214-233	lecithin cholesterol acyltransferase	Mus musculus	78-114
34197964-5	2021	Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine.	Phosphatidylcholines	214-233	lecithin cholesterol acyltransferase	Mus musculus	116-120
34197964-5	2021	Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine.	Phosphatidylcholines	214-233	lipase, endothelial	Mus musculus	123-141
34197964-5	2021	Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine.	Phosphatidylcholines	214-233	lipase, hepatic	Mus musculus	152-166
34197964-5	2021	Our previous studies showed that there are at least three different enzymes - lecithin cholesterol acyltransferase (LCAT), endothelial lipase (EL), and hepatic lipase (HL), which can generate LPC-DHA from sn-2 DHA phosphatidylcholine.	Phosphatidylcholines	214-233	lipase, hepatic	Mus musculus	168-170
34425110-9	2021	Excess retinal de novo lipogenesis - either due to diabetes or due to FAS gain-of-function - was associated with modestly increased levels of palmitate-containing phosphatidylcholine species in synaptic membranes, a finding with as yet uncertain significance.	Phosphatidylcholines	163-182	fatty acid synthase	Mus musculus	70-73
34324831-4	2021	After substitution of endogenous lipids with lipids having an ability to form liquid ordered (Lo) domains (sphingomyelins) or liquid disordered (Ld) domains (unsaturated phosphatidylcholines (PCs)), we found that the propensity of lipids to form ordered domains is required for high IR activity.	Phosphatidylcholines	192-195	insulin receptor	Homo sapiens	283-285
34499764-3	2021	The level of lyso-PC is regulated primarily by lyso-PC acyltransferase 3 (LPCAT3), which acylates lyso-PC to form phosphatidylcholine.	Phosphatidylcholines	114-133	lysophosphatidylcholine acyltransferase 3	Mus musculus	47-72
34499764-3	2021	The level of lyso-PC is regulated primarily by lyso-PC acyltransferase 3 (LPCAT3), which acylates lyso-PC to form phosphatidylcholine.	Phosphatidylcholines	114-133	lysophosphatidylcholine acyltransferase 3	Mus musculus	74-80
34403372-0	2021	A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.	Phosphatidylcholines	87-106	ATPase, class VI, type 11A	Mus musculus	12-18
34445104-7	2021	The conjugates substituted by ANISA and VA, respectively, at both the sn-1 and sn-2 positions of PC, appeared the most promising, since they were effective against the vast majority of metastatic melanoma cell lines.	Phosphatidylcholines	97-99	solute carrier family 38 member 3	Homo sapiens	70-74
34564389-5	2021	We observed that the LDL-lowering HMGCR rs12916-T allele was negatively associated with plasma phosphatidylcholines and sphingomyelins, and HMGCR expression in AT was correlated with various metabolic and mitochondrial pathways.	Phosphatidylcholines	95-115	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	34-39
34490332-4	2021	The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids.	Phosphatidylcholines	80-99	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	4-29
34490332-4	2021	The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids.	Phosphatidylcholines	101-103	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	4-29
34385322-0	2021	Structures of ABCB4 provide insight into phosphatidylcholine translocation.	Phosphatidylcholines	41-60	ATP binding cassette subfamily B member 4	Homo sapiens	14-19
34385322-1	2021	ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi.	Phosphatidylcholines	51-70	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34385322-6	2021	Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 4	Homo sapiens	130-135
34385322-8	2021	Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue.	Phosphatidylcholines	76-95	ATP binding cassette subfamily B member 4	Homo sapiens	151-156
34445104-7	2021	The conjugates substituted by ANISA and VA, respectively, at both the sn-1 and sn-2 positions of PC, appeared the most promising, since they were effective against the vast majority of metastatic melanoma cell lines.	Phosphatidylcholines	97-99	solute carrier family 38 member 5	Homo sapiens	79-83
34445104-10	2021	Again, the conjugates substituted by phenolic acid at both the sn-1 and sn-2 positions of PC seemed to be presumably most bioavailable.	Phosphatidylcholines	90-92	solute carrier family 38 member 3	Homo sapiens	63-67
34445104-10	2021	Again, the conjugates substituted by phenolic acid at both the sn-1 and sn-2 positions of PC seemed to be presumably most bioavailable.	Phosphatidylcholines	90-92	solute carrier family 38 member 5	Homo sapiens	72-76
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	0-19	apolipoprotein E	Homo sapiens	191-195
34421831-3	2021	Two PC synthesis pathways are known in prokaryotes: the PmtA-catalyzed trimethylation of phosphatidylethanolamine and the direct linkage of choline to CDP-diacylglycerol catalyzed by the PC synthase Pcs.	Phosphatidylcholines	4-6	PCS	Homo sapiens	199-202
34421831-4	2021	Previous studies have reported that B. abortus and B. melitensis possess non-functional PmtAs and that PC is synthesized exclusively via Pcs in these strains.	Phosphatidylcholines	103-105	PCS	Homo sapiens	137-140
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	0-19	apolipoprotein E	Homo sapiens	173-189
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	0-19	amyloid beta precursor protein	Homo sapiens	268-280
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	0-19	amyloid beta precursor protein	Homo sapiens	282-287
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	0-19	microtubule associated protein tau	Homo sapiens	301-304
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	21-23	apolipoprotein E	Homo sapiens	173-189
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	21-23	apolipoprotein E	Homo sapiens	191-195
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	21-23	amyloid beta precursor protein	Homo sapiens	268-280
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	21-23	amyloid beta precursor protein	Homo sapiens	282-287
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Phosphatidylcholines	21-23	microtubule associated protein tau	Homo sapiens	301-304
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	102-121	RAS like proto-oncogene A	Homo sapiens	17-21
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	102-121	phospholipase D1	Homo sapiens	53-69
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	102-121	phospholipase D1	Homo sapiens	71-75
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	123-125	RAS like proto-oncogene A	Homo sapiens	17-21
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	123-125	phospholipase D1	Homo sapiens	53-69
34320341-5	2021	Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion.	Phosphatidylcholines	123-125	phospholipase D1	Homo sapiens	71-75
34252282-5	2021	The results suggest that favorable electrostatic interactions of the N-terminal charged residues and the phosphatidylcholine membrane surface are crucial in Abeta-mediated membrane permeation.	Phosphatidylcholines	105-124	amyloid beta precursor protein	Homo sapiens	157-162
34209301-1	2021	ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile.	Phosphatidylcholines	142-161	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34396103-7	2021	However, higher levels of seven phosphatidylcholines (lysoPC a C18:2, PC aa C42:0, PC ae C42:3, PC ae C44:3, PC ae C44:4, PC ae C44:5 and PC ae C44:6) were associated with increased brain amyloid-beta deposition.	Phosphatidylcholines	32-52	amyloid beta precursor protein	Homo sapiens	188-200
34396103-9	2021	Our findings suggest that dysregulation of peripheral phosphatidylcholine metabolism is associated with earlier pathological changes noted in Alzheimer"s disease as measured by brain amyloid-beta deposition as well as later clinical features including changes in memory and executive functioning.	Phosphatidylcholines	54-73	amyloid beta precursor protein	Homo sapiens	183-195
34396103-10	2021	Perturbations in phosphatidylcholine metabolism may point to issues with membrane restructuring leading to the accumulation of amyloid-beta in the brain.	Phosphatidylcholines	17-36	amyloid beta precursor protein	Homo sapiens	127-139
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Phosphatidylcholines	156-175	epidermal growth factor receptor	Homo sapiens	0-32
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Phosphatidylcholines	156-175	epidermal growth factor receptor	Homo sapiens	34-38
34209301-1	2021	ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile.	Phosphatidylcholines	142-161	ATP binding cassette subfamily B member 4	Homo sapiens	7-48
34209301-6	2021	Our results indicate that the overexpression of wild type RAB10 or its dominant-active mutant significantly increases the amount of ABCB4 at the plasma membrane expression and its phosphatidylcholine floppase function.	Phosphatidylcholines	180-199	RAB10, member RAS oncogene family	Homo sapiens	58-63
34209301-6	2021	Our results indicate that the overexpression of wild type RAB10 or its dominant-active mutant significantly increases the amount of ABCB4 at the plasma membrane expression and its phosphatidylcholine floppase function.	Phosphatidylcholines	180-199	ATP binding cassette subfamily B member 4	Homo sapiens	132-137
34209301-8	2021	Taken together, our findings suggest that RAB10 regulates the plasma membrane targeting of ABCB4 and consequently its capacity to mediate phosphatidylcholine secretion.	Phosphatidylcholines	138-157	RAB10, member RAS oncogene family	Homo sapiens	42-47
34209301-8	2021	Taken together, our findings suggest that RAB10 regulates the plasma membrane targeting of ABCB4 and consequently its capacity to mediate phosphatidylcholine secretion.	Phosphatidylcholines	138-157	ATP binding cassette subfamily B member 4	Homo sapiens	91-96
34277122-6	2021	Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin.	Phosphatidylcholines	201-220	carnitine palmitoyltransferase 1C	Homo sapiens	50-55
34205960-1	2021	Choline kinase (CK) is the enzyme catalyzing the first reaction in CDP-choline pathway for the biosynthesis of phosphatidylcholine.	Phosphatidylcholines	111-130	cytidine/uridine monophosphate kinase 1	Homo sapiens	0-19
34221998-12	2021	Majority of fecal lipids including lysophosphatidylcholine and phosphatidylcholine were upregulated in CRPC FMT treated mice, accompanied with enhanced expressions of LPCAT1, RAD51, and DNA-PKcs in mice prostate.	Phosphatidylcholines	63-82	RAD51 recombinase	Mus musculus	175-180
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	C-C motif chemokine ligand 2	Homo sapiens	74-78
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	C-C motif chemokine ligand 4	Homo sapiens	86-90
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	vascular endothelial growth factor A	Homo sapiens	132-136
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	angiopoietin 1	Homo sapiens	138-143
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	angiopoietin 2	Homo sapiens	145-150
33949005-8	2021	Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis.	Phosphatidylcholines	243-262	cystathionine beta-synthase	Mus musculus	77-80
35381375-8	2022	Shotgun lipidomic analysis revealed that ABCA7-HDL had ~20 mol% less phosphatidylcholine and 3-5 times more serine-lipid and phosphatidylinositol than ABCA1-HDL, while ABCA1-HDL contained only ~6 mol% (or ~1.1 times) more cholesterol than ABCA7-HDL.	Phosphatidylcholines	69-88	LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7	Mesocricetus auratus	41-46
34063660-2	2021	The morphology of the supported lipid bilayer (SLB) consisting of PI and phosphatidylcholine (PC) on a mica substrate was observed with atomic force microscope (AFM).	Phosphatidylcholines	73-92	MHC class I polypeptide-related sequence A	Homo sapiens	103-107
34063660-2	2021	The morphology of the supported lipid bilayer (SLB) consisting of PI and phosphatidylcholine (PC) on a mica substrate was observed with atomic force microscope (AFM).	Phosphatidylcholines	94-96	MHC class I polypeptide-related sequence A	Homo sapiens	103-107
35348973-8	2022	Interestingly, the comprehensive analysis of transcriptomics and metabolomics indicated that Asiatic acid inhibited the gene expression of Gpat3 and thereby affected the biosynthesis of the metabolites (1-acyl-Sn-glycerol-3-phosphocholine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine), regulating the glycerophospholipid metabolism pathway and ultimately ameliorating hepatocyte damage.	Phosphatidylcholines	240-259	glycerol-3-phosphate acyltransferase 3	Rattus norvegicus	139-144
35381375-10	2022	Overall, these results suggest that ABCA7 lacks specificity for phosphatidylcholine and releases significantly but not dramatically less cholesterol in comparison with ABCA1.	Phosphatidylcholines	64-83	LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7	Mesocricetus auratus	36-41
35584570-4	2022	Castor phospholipase A2alpha (RcPLA2) has specificity for HFA-containing phosphatidylcholine.	Phosphatidylcholines	73-92	phospholipase A 2A	Arabidopsis thaliana	7-28
35526799-1	2022	LPCAT3, a subtype of lysophosphatidylcholine acyltransferases, is a key enzyme in phosphatidylcholine remodeling pathway and plays a significant role in mediating inflammatory response in mammals.	Phosphatidylcholines	82-101	lysophospholipid acyltransferase 5	Larimichthys crocea	0-6
35442170-1	2022	Development of ARDS in influenza A virus (IAV)-infected mice is associated with inhibition of alveolar type II (ATII) epithelial cell de novo phosphatidylcholine synthesis and administration of the phosphatidylcholine precursor CDP-choline attenuates IAV-induced ARDS in mice.	Phosphatidylcholines	198-217	cut-like homeobox 1	Mus musculus	228-231
35584957-2	2022	Egg yolk is one of the sources of phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	34-53	pyruvate carboxylase	Homo sapiens	55-57
35231605-2	2022	The aim of this study was to investigate the ability of L. micdadei to utilize extracellular choline for phosphatidylcholine (PC) synthesis and its consequences for the phospholipid composition of its membrane system and the interaction with the human LL-37 peptide.	Phosphatidylcholines	126-128	cathelicidin antimicrobial peptide	Homo sapiens	252-257
35575618-1	2022	BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues.	Phosphatidylcholines	155-174	phosphatidylethanolamine N-methyltransferase	Homo sapiens	78-122
35416329-3	2022	The real-time quantitative polymerase chain reaction and promoter-reporter activity revealed a substantial reduction in OPI3 expression and was supported with decreased phosphatidylcholine (PC) level that is rescued with exogenous choline supplementation in gcr1  cells.	Phosphatidylcholines	169-188	transcription regulator GCR1	Saccharomyces cerevisiae S288C	258-262
35416329-3	2022	The real-time quantitative polymerase chain reaction and promoter-reporter activity revealed a substantial reduction in OPI3 expression and was supported with decreased phosphatidylcholine (PC) level that is rescued with exogenous choline supplementation in gcr1  cells.	Phosphatidylcholines	190-192	transcription regulator GCR1	Saccharomyces cerevisiae S288C	258-262
35617134-4	2022	Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly.	Phosphatidylcholines	61-80	vacuole membrane protein 1	Mus musculus	29-33
35617134-4	2022	Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly.	Phosphatidylcholines	82-84	vacuole membrane protein 1	Mus musculus	29-33
35617134-4	2022	Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly.	Phosphatidylcholines	146-148	vacuole membrane protein 1	Mus musculus	29-33
35380992-5	2022	Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury.	Phosphatidylcholines	123-143	SREBF chaperone	Mus musculus	50-54
35380992-5	2022	Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury.	Phosphatidylcholines	123-143	lysophosphatidylcholine acyltransferase 3	Mus musculus	241-282
35380992-5	2022	Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury.	Phosphatidylcholines	123-143	lysophosphatidylcholine acyltransferase 3	Mus musculus	284-290
35380992-5	2022	Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury.	Phosphatidylcholines	217-236	SREBF chaperone	Mus musculus	50-54
35380992-5	2022	Transcriptome and lipidome analyses revealed that SCAP-SREBP pathway inhibition altered the fatty acid (FA) composition of phosphatidylcholines due to both impaired FA synthesis and disorganized FA incorporation into phosphatidylcholine via lysophosphatidylcholine acyltransferase 3 (LPCAT3) downregulation, which led to endoplasmic reticulum (ER) stress and hepatocyte injury.	Phosphatidylcholines	217-236	lysophosphatidylcholine acyltransferase 3	Mus musculus	241-282
35380992-6	2022	Supplementation of phosphatidylcholines significantly improved liver injury and ER stress induced by SCAP deletion.	Phosphatidylcholines	19-39	SREBF chaperone	Mus musculus	101-105
35575618-1	2022	BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues.	Phosphatidylcholines	155-174	phosphatidylethanolamine N-methyltransferase	Homo sapiens	124-128
35575618-1	2022	BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues.	Phosphatidylcholines	176-178	phosphatidylethanolamine N-methyltransferase	Homo sapiens	78-122
35575618-1	2022	BACKGROUND: Dietary methyl donors (e.g., choline) support the activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, which generates phosphatidylcholine (PC) molecules enriched in docosahexaenoic acid (DHA) that are exported from the liver and made available to extrahepatic tissues.	Phosphatidylcholines	176-178	phosphatidylethanolamine N-methyltransferase	Homo sapiens	124-128
35551349-10	2022	The main serum lipids that distinguished both Parkinson"s disease patients and LRRK2 mutation carriers from controls included species of ceramide, triacylglycerol, sphingomyelin, acylcarnitine, phosphatidylcholine and lysophosphatidylethanolamine.	Phosphatidylcholines	194-213	leucine rich repeat kinase 2	Homo sapiens	79-84
35460694-7	2022	Furthermore, miR-141/200c deficiency normalizes ethanol-mediated impairment of TG secretion, which can be attributed to the restored levels of HNF1B and MTTP, as well as phosphatidylcholine abundance.	Phosphatidylcholines	170-189	microRNA 141	Mus musculus	13-25
35560202-2	2022	In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth.	Phosphatidylcholines	117-119	polyol/monosaccharide transporter 1	Arabidopsis thaliana	70-74
35560202-2	2022	In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth.	Phosphatidylcholines	117-119	polyol/monosaccharide transporter 2	Arabidopsis thaliana	76-80
35560202-5	2022	Here, we show that PLMT is ubiquitously expressed in different organs and localized at the endoplasmic reticulum, where PC is produced.	Phosphatidylcholines	120-122	phospholipid N-methyltransferase	Arabidopsis thaliana	19-23
35560202-6	2022	Overexpression of PLMT in planta increased the content of phospholipids including PC and affected vegetative but not reproductive growth.	Phosphatidylcholines	82-84	phospholipid N-methyltransferase	Arabidopsis thaliana	18-22
35560202-9	2022	We conclude that PLMT might be a functional enzyme in PC biosynthesis and play an organ-specific role in developing seeds, where rapid accumulation of triacylglycerol dominates the entire glycerolipid metabolic flux.	Phosphatidylcholines	54-56	phospholipid N-methyltransferase	Arabidopsis thaliana	17-21
35574050-2	2023	Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles (NPs) loaded with plasmid DNA (pDNA) encoding transforming growth factor-beta 1 (TGF-beta1) to engineer MSCs for enhanced OA therapy via cartilage regeneration.	Phosphatidylcholines	44-63	transforming growth factor, beta 1	Mus musculus	133-166
35574050-2	2023	Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles (NPs) loaded with plasmid DNA (pDNA) encoding transforming growth factor-beta 1 (TGF-beta1) to engineer MSCs for enhanced OA therapy via cartilage regeneration.	Phosphatidylcholines	44-63	transforming growth factor, beta 1	Mus musculus	168-177
35474485-7	2022	Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	104-123	skull morphology 20	Mus musculus	39-42
35474485-7	2022	Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	125-127	skull morphology 20	Mus musculus	39-42
35497501-4	2022	found that the fluorescently tagged C2 domain of phospholipase A2 binds to membrane phosphatidylcholine and thus labels vesicle membrane, allowing for super-resolution and electron microscopic visualization of vesicle trafficking.	Phosphatidylcholines	84-103	phospholipase A2 group IB	Homo sapiens	49-65
35411667-11	2022	HSD17B13 perturbs plasma phosphatidylcholines and triglycerides.	Phosphatidylcholines	25-45	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	0-8
35452693-8	2022	Mechanistically, loss of Vmp1 led to decreased hepatic levels of phosphatidylcholine and phosphatidylethanolamine as well as the changes of phospholipid composition.	Phosphatidylcholines	65-84	vacuole membrane protein 1	Mus musculus	25-29
35343224-6	2022	Plasma phosphatidylcholines increased by lipidomics after SCD1 knockout in goats.	Phosphatidylcholines	7-27	stearoyl-CoA desaturase	Capra hircus	58-62
35007755-1	2022	Cytidine triphosphate:phosphocholine cytidylyltransferase-alpha (CTalpha) is the rate limiting enzyme in the pathway for de novo phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	129-148	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	65-72
35019930-5	2022	Based on the strong "N-P" tetravalent electrostatic interaction between MCP and phosphatidyl choline on the erythrocyte membranes, MCP-PEG-FA can be modified on the erythrocyte membrane encapsulated doxorubicin (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) nanosystem to form a tumor-targeting erythrocyte membrane nanosystem (FA-RBC@PLGA-DOX).	Phosphatidylcholines	80-100	CD46 molecule	Homo sapiens	72-75
35007755-1	2022	Cytidine triphosphate:phosphocholine cytidylyltransferase-alpha (CTalpha) is the rate limiting enzyme in the pathway for de novo phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	150-152	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	65-72
35362519-2	2022	In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth.	Phosphatidylcholines	117-119	polyol/monosaccharide transporter 1	Arabidopsis thaliana	70-74
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-25
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	84-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	84-103	phospholipase D1	Homo sapiens	42-46
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	84-103	phospholipase D2	Homo sapiens	51-55
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	105-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-25
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	105-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	105-107	phospholipase D1	Homo sapiens	42-46
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	105-107	phospholipase D2	Homo sapiens	51-55
35362519-2	2022	In Arabidopsis, three copies of the phospho-base N-methyltransferase, PMT1, PMT2, and PMT3, are known to account for PC biosynthesis because the triple-knockout mutant is devoid of biosynthesis and shows lethality in post-embryonic but not embryonic growth.	Phosphatidylcholines	117-119	polyol/monosaccharide transporter 2	Arabidopsis thaliana	76-80
35362519-5	2022	Here, we show that PLMT is ubiquitously expressed in different organs and localized at the endoplasmic reticulum, where PC is produced.	Phosphatidylcholines	120-122	phospholipid N-methyltransferase	Arabidopsis thaliana	19-23
35362519-6	2022	Overexpression of PLMT in planta increased the content of phospholipids including PC and affected vegetative but not reproductive growth.	Phosphatidylcholines	82-84	phospholipid N-methyltransferase	Arabidopsis thaliana	18-22
35362519-9	2022	We conclude that PLMT might be a functional enzyme in PC biosynthesis and play an organ-specific role in developing seeds, where rapid accumulation of triacylglycerol dominates the entire glycerolipid metabolic flux.	Phosphatidylcholines	54-56	phospholipid N-methyltransferase	Arabidopsis thaliana	17-21
35450377-1	2022	Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline.	Phosphatidylcholines	76-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
35322809-3	2022	Using Chkb knockout mice, we reveal that at no stage of the disease is phosphatidylcholine level significantly altered.	Phosphatidylcholines	71-90	choline kinase beta	Mus musculus	6-10
35330412-8	2022	Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD.	Phosphatidylcholines	140-160	inturned planar cell polarity protein	Homo sapiens	85-89
35330412-8	2022	Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD.	Phosphatidylcholines	140-160	FAT atypical cadherin 1	Homo sapiens	91-95
35330412-8	2022	Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD.	Phosphatidylcholines	140-160	contactin 6	Homo sapiens	97-102
35330412-8	2022	Network analysis identified differential associations between four variants (in/near INTU, FAT1, CNTN6, and TM9SF2) and plasma metabolites (phosphatidylcholines, carnitines, biogenic amines, and amino acids) in early- compared with adult-onset MDD.	Phosphatidylcholines	140-160	transmembrane 9 superfamily member 2	Homo sapiens	108-114
35450377-1	2022	Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline.	Phosphatidylcholines	76-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
35151687-1	2022	The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	129-148	choline kinase beta	Mus musculus	4-8
35131264-0	2022	LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling.	Phosphatidylcholines	77-96	lysophosphatidylglycerol acyltransferase 1	Mus musculus	0-6
35131264-3	2022	Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC).	Phosphatidylcholines	193-212	lysophosphatidylglycerol acyltransferase 1	Mus musculus	25-67
35131264-3	2022	Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC).	Phosphatidylcholines	193-212	lysophosphatidylglycerol acyltransferase 1	Homo sapiens	69-75
35150739-6	2022	A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant phospholipid levels due to reductions in the most abundant surfactants, phosphatidylcholine containing di-palmitic acid and phosphatidylcholine species containing the omega-3 fatty acid docosahexaenoic acid.	Phosphatidylcholines	201-220	major facilitator superfamily domain containing 2A	Mus musculus	61-67
35151687-1	2022	The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	129-148	choline kinase beta	Mus musculus	22-41
35150739-6	2022	A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant phospholipid levels due to reductions in the most abundant surfactants, phosphatidylcholine containing di-palmitic acid and phosphatidylcholine species containing the omega-3 fatty acid docosahexaenoic acid.	Phosphatidylcholines	253-272	major facilitator superfamily domain containing 2A	Mus musculus	61-67
35131264-3	2022	Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC).	Phosphatidylcholines	214-216	lysophosphatidylglycerol acyltransferase 1	Mus musculus	25-67
35131264-3	2022	Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC).	Phosphatidylcholines	214-216	lysophosphatidylglycerol acyltransferase 1	Homo sapiens	69-75
35150739-8	2022	Mechanistically, direct tracheal instillation of fluorescent LPC and PC probes indicated that Mfsd2a mediates the uptake of LPC generated by pulmonary phospholipase activity in the alveolar space.	Phosphatidylcholines	69-71	major facilitator superfamily domain containing 2A	Mus musculus	94-100
35151687-1	2022	The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	150-152	choline kinase beta	Mus musculus	4-8
35151687-1	2022	The CHKB gene encodes choline kinase beta, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine (PC).	Phosphatidylcholines	150-152	choline kinase beta	Mus musculus	22-41
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Phosphatidylcholines	266-285	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	82-118
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Phosphatidylcholines	266-285	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	120-124
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Phosphatidylcholines	287-289	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	82-118
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Phosphatidylcholines	287-289	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	120-124
35203270-1	2022	ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile.	Phosphatidylcholines	143-162	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
35163842-7	2022	omega-3 fatty acids (e.g., docosahexaenoic acid) appear to be less prevalent in obese patient RBCs, and this is the case for both the global fatty acid distribution and for the individual major lipids in the membrane phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS).	Phosphatidylcholines	217-236	pyruvate carboxylase	Homo sapiens	238-240
35187037-2	2022	Phosphatidylcholine (PC), a form of choline mostly found in eggs, has been shown to beneficially modulate T-cell responses during the lactation period by increasing the production of IL-2.	Phosphatidylcholines	0-19	interleukin 2	Rattus norvegicus	183-187
35187037-2	2022	Phosphatidylcholine (PC), a form of choline mostly found in eggs, has been shown to beneficially modulate T-cell responses during the lactation period by increasing the production of IL-2.	Phosphatidylcholines	21-23	interleukin 2	Rattus norvegicus	183-187
35048323-0	2022	D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes.	Phosphatidylcholines	19-38	solute carrier family 2 member 4	Homo sapiens	114-119
35203427-5	2022	A sandwich ELISA detecting oxidized phosphatidylcholine in association with apolipoprotein B-100 (oxPL/apoB) was applied to measure oxidized phospholipids in circulation.	Phosphatidylcholines	36-55	apolipoprotein B	Homo sapiens	76-96
35203427-5	2022	A sandwich ELISA detecting oxidized phosphatidylcholine in association with apolipoprotein B-100 (oxPL/apoB) was applied to measure oxidized phospholipids in circulation.	Phosphatidylcholines	36-55	apolipoprotein B	Homo sapiens	103-107
35425434-2	2022	In this study, an attempt has been made to study the interaction involving phosphatidylcholine vesicles (PHOS VES, as model cell membrane) and four different carbon quantum dots bearing different functional groups (-COOH, -NH2, -OH, and protein bovine serum albumin coated) using various tools such as PL behavior, surface charge on vesicles, QCM, ITC, TEM, LSV, and FTIR.	Phosphatidylcholines	75-94	albumin	Homo sapiens	252-265
35185169-4	2022	Moreover, Redundancy analysis (RDA) was used to study the relationship between fatty acids, Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), peroxide value (POV) in Egg Yolk Gel.	Phosphatidylcholines	92-111	pyruvate carboxylase	Homo sapiens	113-115
35048323-5	2022	Here, we show that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4.	Phosphatidylcholines	19-38	insulin	Homo sapiens	100-107
35048323-5	2022	Here, we show that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4.	Phosphatidylcholines	19-38	solute carrier family 2 member 4	Homo sapiens	135-140
2512985-9	1989	These values are at least 10-fold higher than the ratio of 1-alkyl versus 1-acyl species in the cellular phosphatidylcholine precursor for PAF.	Phosphatidylcholines	105-124	PCNA clamp associated factor	Homo sapiens	139-142
35071223-3	2021	In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3.	Phosphatidylcholines	132-134	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	39-43
35071223-3	2021	In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3.	Phosphatidylcholines	132-134	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	165-169
35071223-5	2021	The blockage of PC production is well known to cause endoplasmic reticulum (ER) stress and activate the ER-stress sensor, Ire1, to induce unfolded protein response (UPR).	Phosphatidylcholines	16-18	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	122-126
35503176-4	2022	SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions.	Phosphatidylcholines	103-105	spermine synthase	Homo sapiens	0-3
35367966-0	2022	An Association Between Saturated Fatty Acid-Containing Phosphatidylcholine in Cerebrospinal Fluid with Tau Phosphorylation.	Phosphatidylcholines	55-74	microtubule associated protein tau	Homo sapiens	103-106
2480893-6	1989	Specific activities tested by the capacity to hydrolyze phosphatidylcholines at pH 8.5 decreased as follows: Pa3 greater than Pa5 greater than Pa4 greater than Pa1 greater than Pa2.	Phosphatidylcholines	56-76	Paxip1-associated glutamate-rich protein 1	Rattus norvegicus	160-163
35503176-3	2022	SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC.	Phosphatidylcholines	22-41	sphingomyelin synthase 1	Homo sapiens	0-4
35503176-3	2022	SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC.	Phosphatidylcholines	43-45	sphingomyelin synthase 1	Homo sapiens	0-4
35240344-8	2022	Mechanistically, protection from hepatic inflammation and fibrosis by constitutive mTORC1 occurred via promotion of the phosphatidylcholine synthesizing enzyme, CCTalpha, and enhanced very low-density lipoprotein-triglyceride export.	Phosphatidylcholines	120-139	CREB regulated transcription coactivator 1	Mus musculus	83-89
35240344-8	2022	Mechanistically, protection from hepatic inflammation and fibrosis by constitutive mTORC1 occurred via promotion of the phosphatidylcholine synthesizing enzyme, CCTalpha, and enhanced very low-density lipoprotein-triglyceride export.	Phosphatidylcholines	120-139	t-complex protein 1	Mus musculus	161-169
35367966-10	2022	We propose mechanisms by which saturated PC may promote tau hyperphosphorylation.	Phosphatidylcholines	41-43	microtubule associated protein tau	Homo sapiens	56-59
2513324-6	1989	Inhibitors of protein kinase C prevented the stimulated recycling of phosphatidylcholine, and the simultaneous induction of platelet-activating factor synthesis, by inhibiting phospholipase A2 activation.	Phosphatidylcholines	69-88	phospholipase A2 group IB	Homo sapiens	176-192
2558733-1	1989	It is shown that good estimates of the activity of cholesterol in phosphatidylcholine-cholesterol mixed model membranes are obtained by examining the orientational order parameter S of cholestane spin probe (CSL) that is obtained from electron spin resonance by spectral simulation.	Phosphatidylcholines	66-85	chorionic somatomammotropin hormone like 1	Homo sapiens	208-211
2621418-3	1989	The relative contribution of various PC species towards LCAT reaction in ABL plasma was significantly different from that found in normal plasma.	Phosphatidylcholines	37-39	lecithin-cholesterol acyltransferase	Homo sapiens	56-60
2690829-2	1989	Phorbol 12-myristate 13-acetate (PMA), bombesin, platelet-derived growth factor (PDGF) and vasopressin rapidly stimulated PtdCho hydrolysis, diacylglycerol (DAG) production, and PtdCho synthesis.	Phosphatidylcholines	122-128	peroneal muscular atrophy	Mus musculus	0-37
2690829-2	1989	Phorbol 12-myristate 13-acetate (PMA), bombesin, platelet-derived growth factor (PDGF) and vasopressin rapidly stimulated PtdCho hydrolysis, diacylglycerol (DAG) production, and PtdCho synthesis.	Phosphatidylcholines	178-184	peroneal muscular atrophy	Mus musculus	0-37
2516855-6	1989	The binding equilibrium of apo A-I as to DPPC vesicles at low protein concentrations, as studied by hydrophobic labeling of the bilayer-penetrating segment, is reached within about 1 h, while the formation of micellar complexes at high protein concentrations takes about 24 h at 42 degrees C. Time-dependent labeling studies involving photoreactive phosphatidylcholine (PC) with high apo A-I concentrations suggested an initial interaction with the head group region of the bilayer followed by interaction with the tail ends of the acyl chains of the lipid.	Phosphatidylcholines	349-368	apolipoprotein A1	Homo sapiens	27-34
2516855-6	1989	The binding equilibrium of apo A-I as to DPPC vesicles at low protein concentrations, as studied by hydrophobic labeling of the bilayer-penetrating segment, is reached within about 1 h, while the formation of micellar complexes at high protein concentrations takes about 24 h at 42 degrees C. Time-dependent labeling studies involving photoreactive phosphatidylcholine (PC) with high apo A-I concentrations suggested an initial interaction with the head group region of the bilayer followed by interaction with the tail ends of the acyl chains of the lipid.	Phosphatidylcholines	43-45	apolipoprotein A1	Homo sapiens	27-34
2818589-0	1989	Interleukin 3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line.	Phosphatidylcholines	25-44	interleukin 3	Mus musculus	0-13
2558407-5	1989	However, a clear inhibitory effect is seen when the enzyme is "reconstituted" with sonicated phosphatidylcholine, suggesting that the inhibition of the enzymatic activity is caused by perturbation of the environment of COX in the mitochondrial membrane.	Phosphatidylcholines	93-112	cytochrome c oxidase subunit 8A	Homo sapiens	219-222
2684666-1	1989	PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	167-186	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	0-4
2684666-1	1989	PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	167-186	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	9-13
2624682-2	1989	Some of these regions have been identified by reassembly of the total tryptic peptides of apo B-100 with bovine brain sphingomyelin, 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) and dimyristoylphosphatidylcholine (DPMC).	Phosphatidylcholines	175-179	apolipoprotein B	Bos taurus	90-99
2597670-2	1989	Both natural and synthetic SP-B and SP-C markedly stimulated phosphatidylcholine transfer to alveolar Type II cells and Chinese hamster lung fibroblasts in a dose- and time-dependent fashion.	Phosphatidylcholines	61-80	surfactant protein B	Bos taurus	27-31
2597670-2	1989	Both natural and synthetic SP-B and SP-C markedly stimulated phosphatidylcholine transfer to alveolar Type II cells and Chinese hamster lung fibroblasts in a dose- and time-dependent fashion.	Phosphatidylcholines	61-80	surfactant protein C	Bos taurus	36-40
2818589-3	1989	Treatment of these cells with interleukin 3 rapidly stimulated both the release of water-soluble choline metabolites and the resynthesis of phosphatidylcholine.	Phosphatidylcholines	140-159	interleukin 3	Mus musculus	30-43
2511018-3	1989	The patient"s LpL purified from the PHP by heparin-Sepharose and phenyl-Sepharose chromatographies hydrolysed tributryrin, but not triolein emulsified with Triton X-100 and phosphatidylcholine (PC), or in chylomicrons, whereas normal LpL hydrolysed these substrates.	Phosphatidylcholines	173-192	lipoprotein lipase	Homo sapiens	14-17
2818589-4	1989	Therefore, a phosphatidylcholine cycle may operate as part of the signal transduction pathway in cells responding to interleukin 3.	Phosphatidylcholines	13-32	interleukin 3	Mus musculus	117-130
2480186-3	1989	The apposition of membranes rapidly induced by myelin basic protein is enhanced by sulfatide but reduced by galactocerebroside compared to vesicles of egg phosphatidylcholine alone.	Phosphatidylcholines	155-174	myelin basic protein	Homo sapiens	47-67
2480186-5	1989	Our results support an important modulation by sulfatide and galactocerebroside on the interactions among membranes induced by myelin basic protein, depending on the relative proportions of the glycosphingolipids and phosphatidylcholine.	Phosphatidylcholines	217-236	myelin basic protein	Homo sapiens	127-147
2793844-0	1989	Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils.	Phosphatidylcholines	0-19	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-49
2511018-3	1989	The patient"s LpL purified from the PHP by heparin-Sepharose and phenyl-Sepharose chromatographies hydrolysed tributryrin, but not triolein emulsified with Triton X-100 and phosphatidylcholine (PC), or in chylomicrons, whereas normal LpL hydrolysed these substrates.	Phosphatidylcholines	194-196	lipoprotein lipase	Homo sapiens	14-17
2590161-5	1989	ACAT activity of deoxycholate-solubilized homogenates reconstituted into phosphatidylcholine vesicles was independent of the presence of serum lipoproteins during culture and dependent on cholesterol present in the vesicles for all cell types.	Phosphatidylcholines	73-92	sterol O-acyltransferase 1	Homo sapiens	0-4
2811608-0	1989	Effect of phosphatidylcholine on the alpha-lactalbumin-induced fusion of vesicles.	Phosphatidylcholines	10-29	lactalbumin alpha	Homo sapiens	37-54
2811608-1	1989	Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin.	Phosphatidylcholines	216-235	lactalbumin alpha	Homo sapiens	20-37
2811608-3	1989	This depression of fusion appears to be caused by a reduction in the amount of irreversibly bound alpha-lactalbumin to vesicles containing phosphatidylcholine.	Phosphatidylcholines	139-158	lactalbumin alpha	Homo sapiens	98-115
2549032-17	1989	These data suggest that CCK stimulates both phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis; the latter may contribute to the sustained generation of DAG and hence the maintained activation of protein kinase C.	Phosphatidylcholines	86-105	cholecystokinin	Rattus norvegicus	24-27
2806192-7	1989	Thus, the ability of SP-C to stimulate liposomal PC uptake by rat type II cells could be accounted for by its phospholipid composition.	Phosphatidylcholines	49-51	surfactant protein C	Rattus norvegicus	21-25
2554971-6	1989	Spin-labeled phosphatidylglycerol shows a preferential interaction over the corresponding monogalactosyldiacylglycerol and phosphatidylcholine analogues, in contrast to the common behavior of this lipid in mammalian systems.	Phosphatidylcholines	123-142	spindlin 1	Homo sapiens	0-4
2806192-2	1989	The contribution of these phospholipids to the incorporation of 3H-labeled phosphatidylcholine (PC) liposomes into rat alveolar type II cells stimulated by SP-C was examined.	Phosphatidylcholines	96-98	surfactant protein C	Rattus norvegicus	156-160
2554971-5	1989	Spin-labeled monogalactosyldiacylglycerol exhibits very little preferential interaction over phosphatidylchline, which suggests that part of the role of monogalactosyldiacylglycerol in thylakoid membranes is structural, as is the case for phosphatidylcholine in mammalian membranes.	Phosphatidylcholines	239-258	spindlin 1	Homo sapiens	0-4
2546942-7	1989	From the dependence of the energy transfer upon the acceptor density and assuming kappa 2 = 2/3, the distance of closest approach between a dye in the active site of the thrombin-thrombomodulin complex and a dye at the membrane surface was determined to average 66 A (65 +/- 3 A for phosphatidylcholine vesicles without and 67 +/- 5 A for those with 20% phosphatidylserine).	Phosphatidylcholines	283-302	coagulation factor II, thrombin	Homo sapiens	170-178
2617942-4	1989	The diet of coast Chuchkchee land inhabitants, involving the higher level of unsaturated fatty acids n-3, resulted in the higher ratio between HDL cholesterol and apoA-I, in the higher part of unsaturated fatty acids n-3 in blood plasma lipids (phospholipids and cholesterol esters) and erythrocytes; it led to a relative increase of sphingomyelin and phosphatidyl-ethanolamine and to a decrease of phosphatidylcholine in HDL subfractions.	Phosphatidylcholines	399-418	apolipoprotein A1	Homo sapiens	163-169
2545786-4	1989	When [3H] AA-labeled neutrophils were exposed to PAF, the enhanced release of AA was observed with a concomitant decrease of radioactivity in phosphatidylinositol and phosphatidylcholine fractions.	Phosphatidylcholines	167-186	PCNA clamp associated factor	Homo sapiens	49-52
2815072-9	1989	The % composition of palmitic acid in PC molecule, which is the main component of saturated fatty acid of lung surfactant, was significantly higher in hEGF group than in sham operated group (p less than 0.05).	Phosphatidylcholines	38-40	epidermal growth factor	Homo sapiens	151-155
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	156-175	apolipoprotein A2	Homo sapiens	0-7
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	156-175	apolipoprotein A2	Homo sapiens	102-109
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	156-175	apolipoprotein A1	Homo sapiens	102-108
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	177-179	apolipoprotein A2	Homo sapiens	0-7
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	177-179	apolipoprotein A2	Homo sapiens	102-109
2503030-3	1989	ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids.	Phosphatidylcholines	177-179	apolipoprotein A1	Homo sapiens	102-108
2548919-0	1989	Spin label and microcalorimetric studies of the interaction of DNA with unilamellar phosphatidylcholine liposomes.	Phosphatidylcholines	84-103	spindlin 1 like	Gallus gallus	0-4
2742867-0	1989	18O isotope exchange experiments on phospholipase A2 determined by 13C-NMR: monomeric phosphatidylcholine and micellar phosphatidylethanolamine substrates.	Phosphatidylcholines	86-105	phospholipase A2 group IB	Homo sapiens	36-52
2545711-6	1989	The purified neutral sphingomyelinase (N-SMase) had low levels of phospholipase A1 and A2 activity when phosphatidylcholine was used as a substrate and detergents were included in the assay mixture.	Phosphatidylcholines	104-123	sphingomyelin phosphodiesterase 2	Homo sapiens	13-37
2545711-6	1989	The purified neutral sphingomyelinase (N-SMase) had low levels of phospholipase A1 and A2 activity when phosphatidylcholine was used as a substrate and detergents were included in the assay mixture.	Phosphatidylcholines	104-123	sphingomyelin phosphodiesterase 2	Homo sapiens	39-46
2774696-1	1989	The hydrolysis of radiolabelled Escherichia coli phospholipids, and micellar dispersions of phosphatidylethanolamine and phosphatidylcholine, were used to characterise the phospholipase A2 activity in synovial fluid from patients with rheumatoid arthritis.	Phosphatidylcholines	121-140	phospholipase A2 group IB	Homo sapiens	172-188
2501296-1	1989	Evidence for involvement of protein kinase C. Previous studies demonstrated that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells (Kolesnick, R. N. (1987) J. Biol.	Phosphatidylcholines	147-166	thyrotropin releasing hormone	Rattus norvegicus	100-129
2501296-1	1989	Evidence for involvement of protein kinase C. Previous studies demonstrated that phorbol esters and thyrotropin-releasing hormone (TRH) stimulated phosphatidylcholine synthesis via protein kinase C in GH3 pituitary cells (Kolesnick, R. N. (1987) J. Biol.	Phosphatidylcholines	147-166	thyrotropin releasing hormone	Rattus norvegicus	131-134
2501296-9	1989	This correlated closely with TRH-induced phosphatidylcholine and phosphatidylinositol synthesis; EC50 congruent to 2 x 10(-10) and 1.5 x 10(-10) M TRH, respectively.	Phosphatidylcholines	41-60	thyrotropin releasing hormone	Rattus norvegicus	29-32
2501296-9	1989	This correlated closely with TRH-induced phosphatidylcholine and phosphatidylinositol synthesis; EC50 congruent to 2 x 10(-10) and 1.5 x 10(-10) M TRH, respectively.	Phosphatidylcholines	41-60	thyrotropin releasing hormone	Rattus norvegicus	147-150
2501296-13	1989	Like the effect of TRH on phosphatidylcholine synthesis, TRH-induced sphingomyelin synthesis was abolished in cells "down-modulated" for protein kinase C. In contrast, TRH-induced phosphatidylinositol synthesis still occurred in these cells.	Phosphatidylcholines	26-45	thyrotropin releasing hormone	Rattus norvegicus	19-22
2753160-4	1989	These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN.	Phosphatidylcholines	73-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-56
2753160-4	1989	These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN.	Phosphatidylcholines	73-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	58-61
2751648-1	1989	The effect of tricyclodecan-9-yl-xanthogenate on the phorbolester TPA induced changes in phosphatidylcholine metabolism was investigated.	Phosphatidylcholines	89-108	plasminogen activator, tissue type	Homo sapiens	66-69
2751648-3	1989	The precursor molecule [3H] choline was incorporated into phosphatidylcholine after pulse labeling in TPA/D609-treated cells.	Phosphatidylcholines	58-77	plasminogen activator, tissue type	Homo sapiens	102-105
2487757-4	1989	Hydrolysis of PC and PE with phospholipase A2 (EC 3.1.1.4) released about 50% of the total radioactivity as lipid moieties corresponding to fatty acids.	Phosphatidylcholines	14-16	phospholipase A2 group IB	Rattus norvegicus	29-45
2570849-4	1989	Phosphatidic acid (PA)-specific and phosphatidylcholine (PC)-specific PLA2 activities from rat cerebral cortical synaptosomes were stimulated in incubation medium containing high concentrations of K+ or calcium ionophore A23187.	Phosphatidylcholines	36-55	phospholipase A2 group IB	Rattus norvegicus	70-74
2570849-4	1989	Phosphatidic acid (PA)-specific and phosphatidylcholine (PC)-specific PLA2 activities from rat cerebral cortical synaptosomes were stimulated in incubation medium containing high concentrations of K+ or calcium ionophore A23187.	Phosphatidylcholines	57-59	phospholipase A2 group IB	Rattus norvegicus	70-74
2670666-2	1989	We have demonstrated that the opi3 mutations cause a deficiency in the two terminal phospholipid N-methyltransferase (PLMT) activities required for the de novo synthesis of PC (phosphatidylcholine).	Phosphatidylcholines	173-175	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	30-34
2730887-2	1989	Therefore, we studied the effects of CCl4 on the synthesis of surfactant phosphatidylcholines (PCs) in rat alveolar type II cells in vitro.	Phosphatidylcholines	73-93	C-C motif chemokine ligand 4	Rattus norvegicus	37-41
2730887-7	1989	All of these data suggest that there is a common site(s) at which CCl4 inhibits PC synthesis and that the inhibition occurs early in the biosynthetic pathway.	Phosphatidylcholines	80-82	C-C motif chemokine ligand 4	Rattus norvegicus	66-70
2730887-9	1989	Exposure of alveolar type II cells to CCl4 does cause a rapid and dramatic loss in cellular ATP, a cofactor required by some enzymes involved in PC synthesis.	Phosphatidylcholines	145-147	C-C motif chemokine ligand 4	Rattus norvegicus	38-42
2730888-7	1989	These results show that lecithin-cholesterol acyltransferase has significant effects on the molecular species composition of plasma PC and the deficiency of the enzyme results in accumulation of certain PC species normally used by the enzyme, as well as in abnormal distribution of these species among the lipoproteins.	Phosphatidylcholines	132-134	lecithin-cholesterol acyltransferase	Homo sapiens	24-60
2730888-7	1989	These results show that lecithin-cholesterol acyltransferase has significant effects on the molecular species composition of plasma PC and the deficiency of the enzyme results in accumulation of certain PC species normally used by the enzyme, as well as in abnormal distribution of these species among the lipoproteins.	Phosphatidylcholines	203-205	lecithin-cholesterol acyltransferase	Homo sapiens	24-60
2670666-2	1989	We have demonstrated that the opi3 mutations cause a deficiency in the two terminal phospholipid N-methyltransferase (PLMT) activities required for the de novo synthesis of PC (phosphatidylcholine).	Phosphatidylcholines	177-196	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	30-34
2670666-13	1989	We have used the opi3 strains to demonstrate that synthesis of either PC or PD (phosphatidyldimethylethanolamine) will restore normal regulation of the INO1 gene.	Phosphatidylcholines	70-72	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	17-21
2670666-13	1989	We have used the opi3 strains to demonstrate that synthesis of either PC or PD (phosphatidyldimethylethanolamine) will restore normal regulation of the INO1 gene.	Phosphatidylcholines	70-72	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	152-156
2715209-8	1989	The interference of phosphatidylcholine and/or its metabolite(s) with the cerebral enzyme antioxidant system shows a characteristic specificity as regards both the time of onset and the enzyme activities involved, namely, SOD and glutathione reductase.	Phosphatidylcholines	20-39	glutathione-disulfide reductase	Rattus norvegicus	230-251
2542284-2	1989	When either the solubilized Na+-Ca2+ exchanger or the Na+,K+-ATPase is reconstituted into phosphatidylcholine (PC):phosphatidylserine (30:50 by weight) vesicles, high cholesterol levels (20% by weight) are required for activity to be expressed.	Phosphatidylcholines	90-109	solute carrier family 8 member A1	Homo sapiens	28-46
2542284-2	1989	When either the solubilized Na+-Ca2+ exchanger or the Na+,K+-ATPase is reconstituted into phosphatidylcholine (PC):phosphatidylserine (30:50 by weight) vesicles, high cholesterol levels (20% by weight) are required for activity to be expressed.	Phosphatidylcholines	111-113	solute carrier family 8 member A1	Homo sapiens	28-46
2524476-3	1989	At 1.2 mM Ca2+, 0.50 M ionic strength, pH 7.4, 25 degrees C, fluorescein-labeled PAP-I bound to phospholipid vesicles containing 80% phosphatidylcholine, 20% phosphatidylserine with a Kd of 1.2 +/- 0.2 nM (mean +/- S.D.).	Phosphatidylcholines	133-152	annexin A5	Homo sapiens	81-86
2722792-2	1989	Phosphatidylcholine synthesized in situ in this manner is an acyl donor for retinyl ester synthesis, demonstrating the existence of lecithin:retinol acyltransferase.	Phosphatidylcholines	0-19	lecithin retinol acyltransferase	Homo sapiens	132-164
2540712-6	1989	The hydrophobic labeling studies with photoreactive phosphatidylcholine in the bilayer show that segments of both cytochrome c and apocytochrome c go deep into the bilayer.	Phosphatidylcholines	52-71	cytochrome c, somatic	Homo sapiens	114-126
2541791-13	1989	The discrepancies in the influence of PC on G-6-Pase were interpreted by assuming that the enzyme was a two-component system, a surface-located substrate transporter unit and a membrane integral catalytic phosphohydrolase unit.	Phosphatidylcholines	38-40	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	44-52
2525936-0	1989	Nuclear magnetic resonance spectroscopic studies of interaction of bis-GMA analogues with phosphatidylcholine liposomes as a model for biomembranes.	Phosphatidylcholines	90-109	myelin associated glycoprotein	Homo sapiens	71-74
2736780-1	1989	The accumulation of phosphatidylcholine (PC) in cultured fibroblasts of mucolipidosis IV (MLIV) patients was studied by subcellular fractionation on percoll gradients.	Phosphatidylcholines	20-39	mucolipin TRP cation channel 1	Homo sapiens	90-94
2736780-2	1989	Labelled PC accumulated in secondary lysosomes of the MLIV cells in significantly higher rates when compared to normal controls incubated with the precursors [32P]phosphate or [14C]choline.	Phosphatidylcholines	9-11	mucolipin TRP cation channel 1	Homo sapiens	54-58
2736780-6	1989	In these experiments increased labelled PC in MLIV was also noted in endosomes, which are involved in the uptake process of PC enroute to the lysosomes.	Phosphatidylcholines	40-42	mucolipin TRP cation channel 1	Homo sapiens	46-50
2736780-6	1989	In these experiments increased labelled PC in MLIV was also noted in endosomes, which are involved in the uptake process of PC enroute to the lysosomes.	Phosphatidylcholines	124-126	mucolipin TRP cation channel 1	Homo sapiens	46-50
2775183-8	1989	Thus phosphatidylcholine synthesis via reacylation of lysophosphatidylcholine, via the CDP-choline pathway or via methylation of phosphatidylethanolamine, will satisfy the requirements for secretion of very-low-density lipoprotein from hepatocytes.	Phosphatidylcholines	5-24	cut-like homeobox 1	Rattus norvegicus	87-90
2736780-5	1989	The retention of PC in lysosomes of MLIV could also be demonstrated following incubation of cultured fibroblasts with the radioactive phospholipid itself.	Phosphatidylcholines	17-19	mucolipin TRP cation channel 1	Homo sapiens	36-40
2722775-5	1989	Analysis of PDE:phosphatidylcholine product ratios indicates that the enzyme can conduct multiple methylations of enzyme-bound phospholipid.	Phosphatidylcholines	16-35	aldehyde dehydrogenase 7 family member A1	Homo sapiens	12-15
2496984-3	1989	The hypotheses proposed in the literature for the role of phospholipids in the reconstituted cytochrome P-450 system, mainly based on the comparison of systems without phospholipid and with Lau2GroPCho, were either validated or shown to be unlikely when tested by comparing reconstituted systems with different phosphatidylcholines.	Phosphatidylcholines	311-331	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109
2496984-7	1989	From these observations it is concluded that the higher activity of the Lau2GroPCho system compared with the Ste2GroPCho system or with a system without additional phosphatidylcholine may at least in part be caused by a difference in the conformation of the cytochrome P-450 molecules in these systems.	Phosphatidylcholines	164-183	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	258-274
2496984-8	1989	Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450.	Phosphatidylcholines	43-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-216
2496984-8	1989	Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450.	Phosphatidylcholines	43-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	310-326
2497105-7	1989	On the other hand, phosphatidylcholine vesicles containing either phosphatidylserine or phosphatidylinositol strongly interacted with synapsin I.	Phosphatidylcholines	19-38	synapsin I	Homo sapiens	134-144
2497105-10	1989	Photolabeling of synapsin I was performed with the phosphatidylcholine analogue 1-palmitoyl-2-[11-[4-[3-(trifluoromethyl)diazirinyl]phenyl] [2-3H]undecanoyl]-sn-glycero-3-phosphocholine; this compound generates a highly reactive carbene that selectively interacts with membrane-embedded domains of membrane proteins.	Phosphatidylcholines	51-70	synapsin I	Homo sapiens	17-27
2497106-3	1989	The binding of synapsin I was preserved when synaptic vesicles were solubilized and reconstituted in phosphatidylcholine.	Phosphatidylcholines	101-120	synapsin I	Homo sapiens	15-25
2749908-0	1989	[Complexing of bovine serum albumin with phosphatidyl choline liposomes].	Phosphatidylcholines	41-61	albumin	Homo sapiens	22-35
2749908-1	1989	Thermodynamic parameters of the bovine serum albumin interaction with phosphatidyl choline liposomes have been determined.	Phosphatidylcholines	70-90	albumin	Homo sapiens	39-52
2494162-0	1989	An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma.	Phosphatidylcholines	26-45	phospholipase A2 group VII	Homo sapiens	69-111
2713384-7	1989	Time-course studies showed that in the presence of an LCAT inhibitor there was considerable conversion of phosphatidylcholine to lysophosphatidylcholine in heparin-treated plasma, and that this activity was diminished by 1 M NaCl, but that no phospholipolysis was observed in control plasma.	Phosphatidylcholines	106-125	lecithin cholesterol acyltransferase	Rattus norvegicus	54-58
2494162-7	1989	We now have found that the purified PAF acetylhydrolase catalyzes the hydrolysis of the oxidized fragments of arachidonic acid from the sn-2 position of phosphatidylcholine.	Phosphatidylcholines	153-172	phospholipase A2 group VII	Homo sapiens	36-55
2705543-10	1989	The acetylhydrolase activity was different from phospholipase A2, since phosphatidylcholine was not a substrate for the enzyme.	Phosphatidylcholines	72-91	phospholipase A2 group IB	Homo sapiens	48-64
2539188-1	1989	Neutral phospholipase A2 activity, which hydrolyzed phosphatidylcholine and phosphatidylethanolamine with the same efficiency, was identified in the nuclear matrix prepared from purified nuclei of rat ascites hepatoma cells (AH 7974).	Phosphatidylcholines	52-71	phospholipase A2 group IB	Rattus norvegicus	8-24
2754332-6	1989	A rapid filtration binding assay demonstrated significant binding of cholesterol and phosphatidylcholine in vesicles to gallbladder mucin but only minimal binding of cholesterol and phosphatidylcholine in mixed micelles.	Phosphatidylcholines	85-104	mucin 1, cell surface associated	Bos taurus	132-137
2758074-1	1989	The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied.	Phosphatidylcholines	111-130	phospholipase A2 group IB	Homo sapiens	31-47
2758074-1	1989	The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied.	Phosphatidylcholines	111-130	phospholipase A2 group IIA	Homo sapiens	48-52
2758074-1	1989	The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied.	Phosphatidylcholines	132-134	phospholipase A2 group IB	Homo sapiens	31-47
2758074-1	1989	The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied.	Phosphatidylcholines	132-134	phospholipase A2 group IIA	Homo sapiens	48-52
2760017-1	1989	When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase.	Phosphatidylcholines	132-151	apolipoprotein E	Homo sapiens	29-33
2470427-2	1989	In vesicles composed of phosphatidic acid and phosphatidylcholine, incubation with cytochrome c induced the reorganization of phospholipids into large phosphatidic acid-enriched domains with the exclusion of phosphatidylcholine.	Phosphatidylcholines	46-65	cytochrome c, somatic	Homo sapiens	83-95
2470427-2	1989	In vesicles composed of phosphatidic acid and phosphatidylcholine, incubation with cytochrome c induced the reorganization of phospholipids into large phosphatidic acid-enriched domains with the exclusion of phosphatidylcholine.	Phosphatidylcholines	208-227	cytochrome c, somatic	Homo sapiens	83-95
2760017-1	1989	When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase.	Phosphatidylcholines	132-151	apolipoprotein E	Homo sapiens	11-27
2754332-7	1989	These data indicate that gallbladder mucin binds cholesterol and phosphatidylcholine in vesicles and accelerates the nucleation of cholesterol monohydrate crystals from these cholesterol-transporting particles in supersaturated model bile.	Phosphatidylcholines	65-84	mucin 1, cell surface associated	Bos taurus	37-42
2925651-3	1989	Similarly, phosphatidylcholine synthesis in permeable cells incubated in the presence of exogenous CDP-choline was similar to that of intact hepatocytes and at the expense of microsomal neutral lipid synthesis.	Phosphatidylcholines	11-30	cut-like homeobox 1	Rattus norvegicus	99-102
2466844-11	1989	However, when lipophilin was incorporated into phosphatidylcholine vesicles (50% w/w), small, optically clear suspensions of vesicles were formed.	Phosphatidylcholines	47-66	proteolipid protein 1	Homo sapiens	14-24
2665826-4	1989	The insertion of LPS was probably accompanied by the expulsion of a small portion of phosphatidylcholine molecules from the outer monolayer of LDL into the aqueous medium and by an increase in the phosphatidylethanolamine concentration in LDL.	Phosphatidylcholines	85-104	interferon regulatory factor 6	Homo sapiens	17-20
2704040-2	1989	By measuring surface pressure at constant surface area, p68 was found to interact in a Ca2+ -dependent manner specifically with phosphatidylethanolamine, less so with phosphatidylserine and not at all with phosphatidylcholine.	Phosphatidylcholines	206-225	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	56-59
2646638-6	1989	Hydrolysis of phosphatidylinositol by phospholipase A2 appears to be the source of angiogenin-mobilized arachidonate; angiogenin-induced hydrolysis of phosphatidylcholine was not detected.	Phosphatidylcholines	151-170	angiogenin	Homo sapiens	118-128
2723538-0	1989	Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.	Phosphatidylcholines	14-33	phospholipase A2 group VII	Homo sapiens	70-112
2723538-2	1989	In this study, we have shown that this phospholipid hydrolysis is brought about by an LDL-associated phospholipase A2 that can hydrolyze oxidized but not intact LDL phosphatidylcholine.	Phosphatidylcholines	165-184	phospholipase A2 group VII	Homo sapiens	86-117
2917147-0	1989	Phosphatidylcholine and triacylglycerol hydrolysis in HDL as induced by hepatic lipase: modulation of the phospholipase activity by changes in the particle surface or in the lipid core.	Phosphatidylcholines	0-19	lipase C, hepatic type	Homo sapiens	72-86
2540823-1	1989	Ca2+ binding between lamellae of phosphatidylserine (PS) and phosphatidylcholine (PC) gives rise to a rigid phase of Ca(PS)2.	Phosphatidylcholines	61-80	surfactant protein C	Homo sapiens	82-84
2917151-0	1989	Co-ordinate control of CDP-choline and phosphatidylethanolamine methyltransferase pathways for phosphatidylcholine biosynthesis occurs in response to change in diet fat.	Phosphatidylcholines	95-114	cut like homeobox 1	Homo sapiens	23-26
16347840-3	1989	The solid n-alkanes octadecane (C(18)) and hexatriacontane (C(36)) were encapsulated into phosphatidylcholine bilayers (liposomes).	Phosphatidylcholines	90-109	Bardet-Biedl syndrome 9	Homo sapiens	32-37
2523541-6	1989	Whereas photooxidized egg phosphatidylcholine liposomes underwent total LOOH loss when incubated with PLA2 and GSH/Gpx, no net loss was observed with photooxidized cholesterol/dimyristoyl-phosphatidylcholine liposomes.	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	102-106
2927050-1	1989	A position-specifically labelled phosphatidylcholine is the substrate for the selective determination of Phospholipase A2 in serum, ascites and tissue samples.	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	105-121
2540142-9	1989	Interactions between the P1 and P2 pathways may explain the high potency of extracellular ATP as an agonist of PC exocytosis.	Phosphatidylcholines	111-113	perforin 1	Rattus norvegicus	25-34
2702039-2	1989	TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio.	Phosphatidylcholines	67-86	transforming growth factor beta 1	Homo sapiens	0-8
2541798-0	1989	Synergistic effects in PR3+ transport mediated by ionophores across phosphatidylcholine vesicles.	Phosphatidylcholines	68-87	proteinase 3	Homo sapiens	23-26
2541798-1	1989	Use of a fluorescent probe for the intravesicular pH shows that synergisms previously observed in Pr3+ transport across phosphatidylcholine vesicles are explained by an increase in the proton counter-transport.	Phosphatidylcholines	120-139	proteinase 3	Homo sapiens	98-101
2922759-5	1989	In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner.	Phosphatidylcholines	29-48	patatin like phospholipase domain containing 6	Gallus gallus	151-154
2922759-5	1989	In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner.	Phosphatidylcholines	29-48	patatin like phospholipase domain containing 6	Gallus gallus	278-281
2912496-1	1989	The current study examined the effect of vasopressin on the secretion of phosphatidylcholine, the principal component of pulmonary surfactant, from adult rat alveolar type II pneumocytes in primary culture.	Phosphatidylcholines	73-92	arginine vasopressin	Rattus norvegicus	41-52
2912496-5	1989	The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9.	Phosphatidylcholines	19-38	arginine vasopressin	Rattus norvegicus	50-61
2912496-5	1989	The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9.	Phosphatidylcholines	19-38	arginine vasopressin	Rattus norvegicus	84-95
2912496-9	1989	When vasopressin and isoproterenol were added concomitantly, the effects on phosphatidylcholine secretion were additive.	Phosphatidylcholines	76-95	arginine vasopressin	Rattus norvegicus	5-16
2500989-4	1989	Phospholipase A2 is activated by a variety of physical and chemical agents (e.g. infection, trauma) that increase calcium concentrations in the cell; it releases arachidonic acid from phosphatidyl-choline and phosphatidyl-ethanolamine in particular.	Phosphatidylcholines	184-204	phospholipase A2 group IB	Homo sapiens	0-16
2702039-2	1989	TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio.	Phosphatidylcholines	88-90	transforming growth factor beta 1	Homo sapiens	0-8
2702039-2	1989	TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio.	Phosphatidylcholines	95-97	transforming growth factor beta 1	Homo sapiens	0-8
2647398-1	1989	Based on the cholinergic-deficiency hypothesis of tardive dyskinesia (TD), we administered cytidine diphosphoryl choline (CDP-Choline) (a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine), 500 mg twice a day orally, to four women and one man with TD for 2 to 8 weeks in a double-blind, placebo-controlled crossover trial.	Phosphatidylcholines	203-222	cut like homeobox 1	Homo sapiens	122-125
2849934-1	1988	The ability of bradykinin to stimulate phosphodiesteratic cleavage of phosphatidylcholine (PC) was investigated in bovine pulmonary artery endothelial cells prelabeled with [3H]choline and [3H]myristic acid.	Phosphatidylcholines	91-93	kininogen 1	Bos taurus	15-25
2495252-1	1989	Multilamellar liposomes of phosphatidylcholine and phosphatidylserine at a 7:3 molar ratio significantly inhibited activation of murine resident peritoneal macrophages by recombinant murine interferon-gamma for cytotoxicity against amastigotes of the protozoan parasite Leishmania major; other macrophage effector functions, such as particle phagocytosis or tumoricidal activity, were unaffected.	Phosphatidylcholines	27-46	interferon gamma	Mus musculus	190-206
2811473-1	1989	We have previously shown that interleukin-1 (IL-1) rapidly stimulates the hydrolysis of phosphatidylcholine in the human T lymphocyte cell line, Jurkat (Rosoff, et al., Cell 54: 73-81, 1988).	Phosphatidylcholines	88-107	interleukin 1 alpha	Homo sapiens	30-49
2849934-0	1988	Bradykinin stimulates phosphodiesteratic cleavage of phosphatidylcholine in cultured endothelial cells.	Phosphatidylcholines	53-72	kininogen 1	Bos taurus	0-10
2849934-1	1988	The ability of bradykinin to stimulate phosphodiesteratic cleavage of phosphatidylcholine (PC) was investigated in bovine pulmonary artery endothelial cells prelabeled with [3H]choline and [3H]myristic acid.	Phosphatidylcholines	70-89	kininogen 1	Bos taurus	15-25
2477617-1	1989	A method for measuring the activity of the red cell endogenous phospholipase A is suggested, consisting in red cell destruction, extraction of erythrocytic phospholipase, and detection of the enzymic activity by phosphatidylcholine hydrolysis in the organic phase from the degree of clarification of the lecithin emulsion.	Phosphatidylcholines	212-231	phospholipase A and acyltransferase 1	Homo sapiens	63-78
2498670-2	1989	Both substances can be generated intracellularly by the action of phospholipase A2 on phosphatidylcholine.	Phosphatidylcholines	86-105	phospholipase A2 group IB	Homo sapiens	66-82
2916229-4	1989	Since erythrocytes from ruminant animals contain little or no phosphatidylcholine, perhaps the presence of phosphatidylcholine in the membrane is required for the hemolytic action of T-2 toxin.	Phosphatidylcholines	107-126	solute carrier family 25 member 5	Homo sapiens	183-186
3223955-3	1988	The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor.	Phosphatidylcholines	167-186	phosphatidylethanolamine N-methyltransferase	Homo sapiens	96-140
3196745-0	1988	Substrate specificity of human plasma lecithin-cholesterol acyltransferase towards molecular species of phosphatidylcholine in native plasma.	Phosphatidylcholines	104-123	lecithin-cholesterol acyltransferase	Homo sapiens	38-74
3223955-3	1988	The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor.	Phosphatidylcholines	167-186	phosphatidylethanolamine N-methyltransferase	Homo sapiens	142-146
3196745-1	1988	The specificity of human plasma lecithin-cholesterol acyltransferase for molecular species of phosphatidylcholine (PC) was studied by determining the molecular species composition of whole plasma before and after incubation at 37 degrees C. Since the disappearance of PC under the conditions employed is entirely due to the activity of lecithin-cholesterol acyltransferase, its specificity can be determined from the decrease in the concentration of each species after the reaction.	Phosphatidylcholines	94-113	lecithin-cholesterol acyltransferase	Homo sapiens	32-68
3196745-1	1988	The specificity of human plasma lecithin-cholesterol acyltransferase for molecular species of phosphatidylcholine (PC) was studied by determining the molecular species composition of whole plasma before and after incubation at 37 degrees C. Since the disappearance of PC under the conditions employed is entirely due to the activity of lecithin-cholesterol acyltransferase, its specificity can be determined from the decrease in the concentration of each species after the reaction.	Phosphatidylcholines	94-113	lecithin-cholesterol acyltransferase	Homo sapiens	336-372
3196745-7	1988	These results indicate that in native plasma, lecithin-cholesterol acyltransferase prefers 16:0 greater than 18:1 greater than 18:0 at the 1-position and 18:2 greater than 18:1 greater than 22:6 greater than 20:4 at the 2-position of PC.	Phosphatidylcholines	234-236	lecithin-cholesterol acyltransferase	Homo sapiens	46-82
3223955-3	1988	The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor.	Phosphatidylcholines	188-194	phosphatidylethanolamine N-methyltransferase	Homo sapiens	96-140
3223955-3	1988	The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor.	Phosphatidylcholines	188-194	phosphatidylethanolamine N-methyltransferase	Homo sapiens	142-146
3223955-10	1988	In the presence of endogenous substrates, the rates of PeMT-catalysed PtdCho formation within homogenates of rat mammary tissue were similar in tissue from lactating and non-lactating animals.	Phosphatidylcholines	70-76	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	55-59
2851994-3	1988	In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w).	Phosphatidylcholines	306-325	coagulation factor II, thrombin	Homo sapiens	78-86
2850176-3	1988	We found that its subcellular localization (mainly in microsomal and cytosolic fractions) was different from that of phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17), the enzyme of the alternative pathway for phosphatidylcholine synthesis.	Phosphatidylcholines	219-238	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	117-161
3202520-8	1988	We discovered that calcium and phosphatidylcholine both enhanced, but ATP inhibited, the 15-lipoxygenase activity of highly enriched enzyme.	Phosphatidylcholines	31-50	arachidonate 15-lipoxygenase	Homo sapiens	89-104
2851994-3	1988	In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w).	Phosphatidylcholines	306-325	thrombomodulin	Homo sapiens	172-186
3244018-1	1988	A new method for reconstituting acyl coenzyme A: cholesterol acyltransferase (ACAT) activity from either Chinese hamster ovary (CHO) or human fibroblast cell extracts into cholesterol-phosphatidylcholine liposomes is described.	Phosphatidylcholines	184-203	carboxylesterase 1	Homo sapiens	32-76
3244018-1	1988	A new method for reconstituting acyl coenzyme A: cholesterol acyltransferase (ACAT) activity from either Chinese hamster ovary (CHO) or human fibroblast cell extracts into cholesterol-phosphatidylcholine liposomes is described.	Phosphatidylcholines	184-203	sterol O-acyltransferase 1	Cricetulus griseus	78-82
2846391-2	1988	The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells.	Phosphatidylcholines	46-65	cut like homeobox 1	Homo sapiens	4-7
2846571-4	1988	Effects of vanadate on the function of a guanine nucleotide-binding protein were investigated in a reconstituted model system consisting of purified transducin subunits (T alpha, T beta gamma) and rhodopsin in phosphatidylcholine vesicles.	Phosphatidylcholines	210-229	rhodopsin	Homo sapiens	197-206
3146971-3	1988	In studies of the effect on PA synthesis de novo, insulin stimulated [2-3H]glycerol incorporation into PA, DAG, PC/PE and total glycerolipids of BC3H-1 myocytes, regardless of whether insulin was added simultaneously with, or after 2 h or 3 or 10 days of prelabelling with, [2-3H]glycerol.	Phosphatidylcholines	112-114	insulin	Homo sapiens	50-57
3264481-2	1988	It was postulated that phospholipase A2 (PLA2) exposure would potentiate porcine pancreatic elastase (PPE)-induced epithelial solute permeability in a manner similar to that which was previously shown with lysophosphatidylcholine (lysoPC), a naturally occurring, membrane-perturbing agent that is formed principally through the hydrolysis of phosphatidylcholine by PLA2.	Phosphatidylcholines	210-229	phospholipase A2 group IB	Homo sapiens	41-45
3191996-5	1988	In cells transformed with human or mouse A-raf carrying retroviruses TPA-stimulated PtdCho hydrolysis, but not CerPCho synthesis, suggesting independent regulation of these processes by the TPA-stimulated signal transduction system.	Phosphatidylcholines	84-90	Araf proto-oncogene, serine/threonine kinase	Mus musculus	41-46
3146971-10	1988	In addition to increases in [3H]glycerol labelling of PC/PE, insulin rapidly (within 30 s) increased PC/PE labelling by [3H]arachidonic acid, [3H]myristic acid, and [14C]choline.	Phosphatidylcholines	54-56	insulin	Homo sapiens	61-68
2846391-2	1988	The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells.	Phosphatidylcholines	67-69	cut like homeobox 1	Homo sapiens	4-7
3230188-7	1988	Comparison of fatty acid profiles for phosphatidylcholine with those for lysophosphatidylcholine and cholesterol esters indicated plasma lecithin-cholesterol acyltransferase was active in calves at all three ages studied.	Phosphatidylcholines	38-57	lecithin-cholesterol acyltransferase	Bos taurus	137-173
3199820-3	1988	GR was present at least 2 days prior to gestational day 18, from which day maternal betamethasone administration stimulated choline chloride incorporation into phosphatidylcholine, the major phospholipid in surfactant.	Phosphatidylcholines	160-179	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-2
3149286-1	1988	Apolipoprotein A-I was purified from human high density lipoprotein and complexed with polyunsaturated phosphatidylcholine (PC) in deoxycholate (Lipostabil); the bile salt was removed subsequently by dialysis.	Phosphatidylcholines	124-126	apolipoprotein A1	Homo sapiens	0-18
3170606-8	1988	Upon chromatography of the PC-stabilized enzyme on concanavalin A-agarose almost complete retention occurred at 0.4% Nonidet P-40, while no binding took place at a detergent concentration of 0.075%; this suggested that upon dilution in the presence of PC, the oligosaccharyltransferase was reconstituted into vesicles in an asymmetric fashion with its N-linked carbohydrate located internally.	Phosphatidylcholines	27-29	interleukin 9	Homo sapiens	125-129
2850468-5	1988	In cho2 and opi3 mutants, which are blocked in phosphatidylcholine synthesis, inositol-mediated repression of PGPS did not occur unless choline was added to the media.	Phosphatidylcholines	47-66	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	12-16
2849424-6	1988	The effects of isoprenaline, oxytocin and insulin on the incorporation of [3H]choline into phosphatidylcholine were paralleled by changes in the activity of CTP:phosphocholine cytidylyltransferase.	Phosphatidylcholines	91-110	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	157-196
3178828-1	1988	This report demonstrates that exogenous phosphatidylcholine will serve as an acyl donor for the esterification of retinol complexed to cellular retinol-binding protein (CRBP) by human and rat liver microsomal preparations.	Phosphatidylcholines	40-59	retinol binding protein 1	Homo sapiens	135-167
3178828-1	1988	This report demonstrates that exogenous phosphatidylcholine will serve as an acyl donor for the esterification of retinol complexed to cellular retinol-binding protein (CRBP) by human and rat liver microsomal preparations.	Phosphatidylcholines	40-59	retinol binding protein 1	Homo sapiens	169-173
3235916-0	1988	Cyclopentanoid analogs of phosphatidylcholine: susceptibility to phospholipase A2.	Phosphatidylcholines	26-45	phospholipase A2 group IB	Homo sapiens	65-81
3207703-0	1988	Equilibrium and dynamic bilayer structural properties of unsaturated acyl chain phosphatidylcholine-cholesterol-rhodopsin recombinant vesicles and rod outer segment disk membranes as determined from higher order analysis of fluorescence anisotropy decay.	Phosphatidylcholines	80-99	rhodopsin	Bos taurus	112-121
3242951-7	1988	Our model also explains the facilitation of precipitation observed when phosphatidylcholine is contained in the palmitate-bile salt mixed micelles and the inhibitory effect of the water soluble bovine serum albumin.	Phosphatidylcholines	72-91	albumin	Homo sapiens	201-214
3139038-2	1988	The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate.	Phosphatidylcholines	85-104	lactalbumin alpha	Bos taurus	195-212
3139038-2	1988	The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate.	Phosphatidylcholines	85-104	lactalbumin alpha	Bos taurus	239-256
3139038-7	1988	The presence of phosphatidylcholine abolished the break demonstrating that full activity of the enzyme required both alpha-lactalbumin and lipid.	Phosphatidylcholines	16-35	lactalbumin alpha	Bos taurus	117-134
3196662-8	1988	Owing to the high lipid aqueous partition coefficient of BaP, it is concluded that the direct adsorption of BaP on to the fibres will be negligible when PC is present in the system even at low concentrations.	Phosphatidylcholines	153-155	prohibitin 2	Homo sapiens	108-111
3149278-3	1988	Phosphatidylcholine or phosphatidylethanolamine with arachidonate at the sn-2 position of glycerol was cleaved efficiently by phospholipase A2 activity in homogenates as well as in the cytoplasmic fraction of human platelets, leading to the selective liberation of free arachidonate, whereas phospholipids with linoleate were hardly hydrolyzed under the same conditions.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	126-142
3050446-1	1988	Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes.	Phosphatidylcholines	153-172	G protein-coupled receptor kinase 7	Bos taurus	0-16
3050446-1	1988	Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes.	Phosphatidylcholines	153-172	rhodopsin	Bos taurus	120-129
3143410-4	1988	In general, increasing the pi i of lipid monolayers reduces the adsorption of apolipoprotein A-I; for expanded egg phosphatidylcholine (PC) monolayers at pi i greater than or equal to 32 dyn/cm, gamma and delta pi are zero.	Phosphatidylcholines	115-134	apolipoprotein A1	Homo sapiens	78-96
3420613-3	1988	Metyrapone also reduced the CCl4-related increase in the PLC-mediated reductions in cellular phosphatidylcholine content.	Phosphatidylcholines	93-112	C-C motif chemokine ligand 4	Rattus norvegicus	28-32
2840908-7	1988	Phosphatidylinositol and phosphatidylcholine hydrolysis measured upon thrombin treatment as well as phosphatidic acid production were reduced or suppressed in the presence of the drugs.	Phosphatidylcholines	25-44	coagulation factor II, thrombin	Homo sapiens	70-78
3410848-6	1988	Here we report that this activity in intestinal microsomes will catalyze the transfer of acyl moieties from exogenous phosphatidylcholine (PC) to retinol-CRBP(II) to produce retinyl esters.	Phosphatidylcholines	118-137	retinol binding protein 2	Rattus norvegicus	154-161
3410848-6	1988	Here we report that this activity in intestinal microsomes will catalyze the transfer of acyl moieties from exogenous phosphatidylcholine (PC) to retinol-CRBP(II) to produce retinyl esters.	Phosphatidylcholines	139-141	retinol binding protein 2	Rattus norvegicus	154-161
3410848-7	1988	The microsomal activity displayed positional selectivity as only the sn-1-acyl moiety of PC was transferred to retinol-CRBP(II).	Phosphatidylcholines	89-91	retinol binding protein 2	Rattus norvegicus	119-127
3137572-1	1988	Spin-labeled phospholipids have been used to study the outside----inside and inside----outside transport of phospholipids across the human erythrocyte membrane at 37 degrees C. As already shown, inward transport is much faster for aminophospholipids than for phosphatidylcholine.	Phosphatidylcholines	259-278	spindlin 1	Homo sapiens	0-4
3166380-6	1988	Substituting the neutral phosphatidylcholine with the negatively-charged phosphatidylserine vesicles resulted in a slower rate as well as lesser total uptake of P12.	Phosphatidylcholines	25-44	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	161-164
3417866-4	1988	In contrast, exogenous PLA2 treatment of hypoxic tubules resulted in a severe degree of cell injury, as demonstrated by marked declines in tubule K+ and ATP contents and significant decreases in tubule uncoupled respiratory rates, and was associated with significant phospholipid alterations, including marked declines in phosphatidylcholine (PC) and PE and significant rises in LPC, LPE, and free fatty acids (FFA).	Phosphatidylcholines	322-341	phospholipase A2	Oryctolagus cuniculus	23-27
3417866-4	1988	In contrast, exogenous PLA2 treatment of hypoxic tubules resulted in a severe degree of cell injury, as demonstrated by marked declines in tubule K+ and ATP contents and significant decreases in tubule uncoupled respiratory rates, and was associated with significant phospholipid alterations, including marked declines in phosphatidylcholine (PC) and PE and significant rises in LPC, LPE, and free fatty acids (FFA).	Phosphatidylcholines	343-345	phospholipase A2	Oryctolagus cuniculus	23-27
2971218-2	1988	We have measured phosphatidylinositol-specific phospholipase C and phosphatidylcholine-specific phospholipase A2 in the reproductive tract of male and female mouse (CD-I) fetuses at the 18th day of gestation.	Phosphatidylcholines	67-86	phospholipase A2, group IB, pancreas	Mus musculus	96-112
3401474-0	1988	The effect of alpha-lactalbumin on the thermotropic phase behaviour of phosphatidylcholine bilayers, studied by fluorescence polarization, differential scanning calorimetry and Raman spectroscopy.	Phosphatidylcholines	71-90	lactalbumin alpha	Bos taurus	14-31
3403556-0	1988	Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase A2.	Phosphatidylcholines	14-33	phospholipase A2 group IB	Homo sapiens	96-112
3403556-0	1988	Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase A2.	Phosphatidylcholines	37-56	phospholipase A2 group IB	Homo sapiens	96-112
3403556-1	1988	Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates.	Phosphatidylcholines	68-87	phospholipase A2 group IB	Homo sapiens	11-27
3403556-1	1988	Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates.	Phosphatidylcholines	68-87	phospholipase A2 group IB	Homo sapiens	29-33
3403556-1	1988	Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates.	Phosphatidylcholines	89-91	phospholipase A2 group IB	Homo sapiens	11-27
3403556-1	1988	Pancreatic phospholipase A2 (PLA2)-catalyzed hydrolysis of egg yolk phosphatidylcholine (PC) in mixed PC-cholate systems depends upon composition, structure, and size of the mixed aggregates.	Phosphatidylcholines	89-91	phospholipase A2 group IB	Homo sapiens	29-33
3044366-1	1988	Insulin was found to provoke simultaneous, rapid, biphasic increases in [3H]choline-labeling of phosphatidylcholine and phosphocholine in BC3H-1 myocytes.	Phosphatidylcholines	96-115	insulin	Homo sapiens	0-7
3178736-4	1988	After an initial lag of 30 min, the release of [3H]lysophosphatidylcholine was linear for at least 4 h. At low concentrations, albumin slightly stimulated [3H]phosphatidylcholine release.	Phosphatidylcholines	55-74	albumin	Rattus norvegicus	127-134
3136794-0	1988	A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo.	Phosphatidylcholines	31-50	coagulation factor VIII	Canis lupus familiaris	88-99
3396665-3	1988	Therefore, we have examined the effect of TCE on the intra- and extracellular surfactant pools and the activity of phospholipase A2, an enzyme which controls the remodeling of phosphatidylcholine to dipalmitoylphosphatidylcholine, the primary constituent of the pulmonary surfactant.	Phosphatidylcholines	176-195	phospholipase A2, group IB, pancreas	Mus musculus	115-131
3136794-1	1988	A combination of phosphatidylcholine-phosphatidylserine lipid vesicles (PCPS), as a source of coagulant active phospholipid, when infused with factor Xa bypasses factor VIII in vivo.	Phosphatidylcholines	17-36	coagulation factor VIII	Canis lupus familiaris	162-173
3045250-0	1988	Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline.	Phosphatidylcholines	90-110	CD5 molecule	Homo sapiens	62-65
2847107-3	1988	Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid.	Phosphatidylcholines	124-143	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	52-55
3183519-14	1988	Lamellar body phosphatidylcholine contained four monoenoic fatty acids: 1) palmitoleic acid, 16:1 cis-9; 2) oleic acid, 18:1 cis-9; 3) cis-vaccenic acid, 18:1 cis-11; and 4) 6-hexadecenoic acid, 16:1 cis-6.	Phosphatidylcholines	14-33	suppressor of cytokine signaling 5	Homo sapiens	200-205
2847107-3	1988	Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid.	Phosphatidylcholines	214-233	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	52-55
2847107-3	1988	Infusion of the triple combination of cortisol plus TRH plus beta-agonist resulted in a 20.9-fold increase in the saturated phosphatidylcholine content of fetal lung lavage, in a 5.8-fold increase in the saturated phosphatidylcholine content of whole fetal lung, and in a 13.3-fold increase in the saturated phosphatidylcholine content of fetal tracheal fluid.	Phosphatidylcholines	214-233	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	52-55
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	156-158	interleukin 1 alpha	Homo sapiens	41-45
3132984-0	1988	Transformation of large discoidal complexes of apolipoprotein A-I and phosphatidylcholine by lecithin-cholesterol acyltransferase.	Phosphatidylcholines	70-89	lecithin-cholesterol acyltransferase	Homo sapiens	93-129
2971392-6	1988	In one such case involving liposomes composed of PA/PS/PE/phosphatidylcholine (PC) (10:15:65:10), synexin reduced the fusion rate constant by 50%.	Phosphatidylcholines	58-77	annexin A7	Homo sapiens	98-105
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	156-158	interleukin 1 alpha	Homo sapiens	60-64
3382674-0	1988	Regulation of the human leukocyte 5-lipoxygenase: stimulation by micromolar Ca2+ levels and phosphatidylcholine vesicles.	Phosphatidylcholines	92-111	arachidonate 5-lipoxygenase	Homo sapiens	34-48
3382674-2	1988	In the present study, phosphatidylcholine (PC) vesicles, in the absence of 100,000 x g pellet, exhibited a dose-dependent stimulatory activity on the 5-lipoxygenase, which was at least as effective as the 100,000 x g pellet.	Phosphatidylcholines	22-41	arachidonate 5-lipoxygenase	Homo sapiens	150-164
3130896-7	1988	It is concluded that in hepatocytes vasopressin increases diacylglycerols by a process which does not principally involve the conversion of phosphoinositides to diacylglycerol or the de novo synthesis of diacylglycerol from glycerol 3-phosphate, but does involve the Ca2+-dependent conversion of phosphatidylethanolamine and phosphatidylcholine to diacylglycerol.	Phosphatidylcholines	325-344	arginine vasopressin	Homo sapiens	36-47
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	135-154	interleukin 1 alpha	Homo sapiens	41-45
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	135-154	interleukin 1 alpha	Homo sapiens	60-64
3134504-5	1988	Arachidonic acid utilized in the production of eicosanoids is derived from phospholipids by the action of phospholipase A2 and phospholipase C. When U937 cells were cultured in medium supplemented with gamma-interferon, there was a striking increase in the level of phosphatidylcholine and phosphatidylethanolamine-specific phospholipase A2 activities and phosphatidylinositol-specific phospholipase C activity as compared to control cells.	Phosphatidylcholines	266-285	phospholipase A2 group IB	Homo sapiens	106-122
3391168-7	1988	When bovine intact cytochrome b5 was reconstituted into egg yolk phosphatidylcholine liposomes, although separate signals due to the protein part were observed in the normal 1H-NMR spectrum, no photo-CIDNP signal could be detected.	Phosphatidylcholines	65-84	cytochrome b5 type A	Bos taurus	19-32
3202919-3	1988	The composition of the fatty acids in phosphatidylcholine in the outer leaflet of the bilayer was determined after hydrolysis of outer leaflet phospholipids, first with phospholipase A2 and subsequently with sphingomyelinase.	Phosphatidylcholines	38-57	phospholipase A2 group IB	Rattus norvegicus	169-185
3131322-1	1988	The kinetics of the Ca2+-dependent, alkaline pH optimum, membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line were studied using various phosphatidylcholine (PC) and phosphatidylethanolamine (PE) substrates.	Phosphatidylcholines	158-177	phospholipase A2, group IB, pancreas	Mus musculus	72-88
2458317-3	1988	Chromatographic analysis of [3H]arachidonic acid labeled phospholipids showed that stimulation by FMLP reduced the amount of labeled phosphatidylcholine exclusively.	Phosphatidylcholines	133-152	formyl peptide receptor 1	Homo sapiens	98-102
2459283-3	1988	Filipin successfully stained discoidal complexes of apoA-I-phosphatidylcholine-cholesterol, which in turn were stained poorly with oil red O.	Phosphatidylcholines	59-78	apolipoprotein A1	Homo sapiens	52-58
2835102-1	1988	The intramembrane locations of several spin labeled probes in small egg phosphatidylcholine (egg PC) vesicles were determined from the enhancement of the 13C nuclear spin lattice relaxation of the membrane phospholipid.	Phosphatidylcholines	72-91	spindlin 1	Homo sapiens	39-43
2835102-1	1988	The intramembrane locations of several spin labeled probes in small egg phosphatidylcholine (egg PC) vesicles were determined from the enhancement of the 13C nuclear spin lattice relaxation of the membrane phospholipid.	Phosphatidylcholines	72-91	spindlin 1	Homo sapiens	166-170
3227920-0	1988	Plasma pattern of growth hormone regulates sexual differentiation of phosphatidylcholine in rat plasma.	Phosphatidylcholines	69-88	gonadotropin releasing hormone receptor	Rattus norvegicus	18-32
3133132-6	1988	In hypoxic myocardium, this phospholipase A2 activity markedly increased and had substrate specificity toward phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	110-129	phospholipase A2 group IB	Rattus norvegicus	28-44
3238311-5	1988	We found that the release of both AA and NAG was coupled to a degradation of phosphatidylcholine (PC), and that the neutrophils were able to metabolise lower, but not higher, concentrations of lysoPC.	Phosphatidylcholines	77-96	O-GlcNAcase	Homo sapiens	41-44
3238311-5	1988	We found that the release of both AA and NAG was coupled to a degradation of phosphatidylcholine (PC), and that the neutrophils were able to metabolise lower, but not higher, concentrations of lysoPC.	Phosphatidylcholines	98-100	O-GlcNAcase	Homo sapiens	41-44
3238311-6	1988	Moreover, the phospholipase A2 inhibitor, nordihydroguaiaretic acid significantly inhibited PC degradation, lysoPC formation, and NAG release, whereas the lipoxygenase inhibitor, BW 755C had little effect on these parameters.	Phosphatidylcholines	92-94	phospholipase A2 group IB	Homo sapiens	14-30
3365445-5	1988	The results indicated that in rat platelets, PC synthesis occurred mainly via the CDP-choline pathway, and suggested that CTP:phosphocholine cytidylyltransferase was the rate-limiting step; they also indicated that the activity of this enzyme and that of choline kinase might be enhanced in SHR platelets compared to Wistar-Kyoto rat (WKY) platelets, and may thus be responsible for the enhanced PC synthesis.	Phosphatidylcholines	396-398	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	122-161
3284590-1	1988	Protein-mediated transfer of phosphatidylcholine (PC) by bovine liver phosphatidylcholine transfer protein (PC-TP) was examined using a vesicle-vesicle assay system.	Phosphatidylcholines	29-48	phosphatidylcholine transfer protein	Bos taurus	108-113
3284590-1	1988	Protein-mediated transfer of phosphatidylcholine (PC) by bovine liver phosphatidylcholine transfer protein (PC-TP) was examined using a vesicle-vesicle assay system.	Phosphatidylcholines	50-52	phosphatidylcholine transfer protein	Bos taurus	108-113
3284590-7	1988	In addition, kinetic analysis revealed that the presence of PC in acceptor vesicles increased both the association and dissociation of PC-TP from vesicles.	Phosphatidylcholines	60-62	phosphatidylcholine transfer protein	Bos taurus	135-140
3284590-10	1988	The results suggest that transfer of PC by PC-TP is enhanced only when insertion of protein-bound PC occurs concurrently with the extraction of a molecule of membrane PC, i.e., a concerted, one-step catalytic mechanism for phospholipid exchange.	Phosphatidylcholines	37-39	phosphatidylcholine transfer protein	Bos taurus	43-48
3365241-0	1988	Vasopressin is the only component of serum-free medium that stimulates phosphatidylcholine hydrolysis and accumulation of diacylglycerol in cultured REF52 cells.	Phosphatidylcholines	71-90	arginine vasopressin	Rattus norvegicus	0-11
3365241-1	1988	Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels).	Phosphatidylcholines	23-42	arginine vasopressin	Rattus norvegicus	0-11
3365241-1	1988	Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels).	Phosphatidylcholines	79-98	arginine vasopressin	Rattus norvegicus	0-11
2833508-2	1988	Under these conditions, CTP:phosphocholine cytidylyltransferase activity, which is known to catalyze the rate-limiting step in phosphatidylcholine biosynthesis, was stimulated 32% (p less than 0.001) over control cells.	Phosphatidylcholines	127-146	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	24-63
2833508-8	1988	We further conclude that the final step in the de novo pathway for PAF biosynthesis is under the direct control of CTP:phosphocholine cytidylyltransferase, which emphasizes the importance of this regulatory (rate-limiting) step in the biosynthesis of both phosphatidylcholine and PAF.	Phosphatidylcholines	256-275	patchy fur	Mus musculus	67-70
3365241-2	1988	Vasopressin is the only component of a 6-component mixture of the serum-free medium for REF52 cells that induces the phosphatidylcholine hydrolysis response.	Phosphatidylcholines	117-136	arginine vasopressin	Rattus norvegicus	0-11
2833508-8	1988	We further conclude that the final step in the de novo pathway for PAF biosynthesis is under the direct control of CTP:phosphocholine cytidylyltransferase, which emphasizes the importance of this regulatory (rate-limiting) step in the biosynthesis of both phosphatidylcholine and PAF.	Phosphatidylcholines	256-275	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	115-154
3365241-4	1988	Maximal levels of both phosphatidyl-choline hydrolysis and accumulation of diacylglycerol are observed between 10 and 20 min after treatment with vasopressin.	Phosphatidylcholines	23-43	arginine vasopressin	Rattus norvegicus	146-157
3365241-5	1988	Effects are maximal at vasopressin concentrations of 100 ng/ml; the ED50 for vasopressin-stimulated phosphatidyl-choline hydrolysis is approximately 0.7 ng/ml.	Phosphatidylcholines	100-120	arginine vasopressin	Rattus norvegicus	77-88
2833521-19	1988	The results support the hypothesis that Golgi has the capacity to make certain phospholipids for lipoprotein secretion: phosphatidylcholine via the CDP-choline and methylation pathways, phosphatidylethanolamine by the CDP-ethanolamine pathway, and phosphatidylserine.	Phosphatidylcholines	120-139	cut-like homeobox 1	Rattus norvegicus	148-151
3378037-0	1988	Kinetics of fluorescent-labeled phosphatidylcholine transfer between nonspecific lipid transfer protein and phospholipid vesicles.	Phosphatidylcholines	32-51	sterol carrier protein 2	Rattus norvegicus	69-103
3355851-0	1988	Sex differences in fatty acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth hormone.	Phosphatidylcholines	55-74	gonadotropin releasing hormone receptor	Rattus norvegicus	114-128
3128333-8	1988	Similar experiments using cholesteryl linoleate/egg phosphatidylcholine liposomes showed that inclusion of apo A-I resulted in a pronounced increase in the uptake of cholesteryl linoleate and progestin synthesis.	Phosphatidylcholines	52-71	apolipoprotein A1	Rattus norvegicus	107-114
2833496-1	1988	The plasma cholesteryl ester-transfer protein (CETP, Mr 74,000) promotes exchange of both neutral lipids and phospholipids (phosphatidylcholine, PC) between lipoproteins.	Phosphatidylcholines	124-143	cholesteryl ester transfer protein	Homo sapiens	11-45
2833496-1	1988	The plasma cholesteryl ester-transfer protein (CETP, Mr 74,000) promotes exchange of both neutral lipids and phospholipids (phosphatidylcholine, PC) between lipoproteins.	Phosphatidylcholines	124-143	cholesteryl ester transfer protein	Homo sapiens	47-51
3170511-4	1988	The L929 cells excreted the degradation products of TNF into the culture medium, and this medium showed activity for degradation of liposomes composed of phosphatidylserine and phosphatidylcholine.	Phosphatidylcholines	177-196	tumor necrosis factor	Mus musculus	52-55
2454133-5	1988	However, a redistribution of both gramicidin and dansyl-labeled phospholipids was easily observed when a phase separation was induced by adding Ca2+ to vesicles made up of phosphatidylcholine and phosphatidic acid.	Phosphatidylcholines	172-191	carbonic anhydrase 2	Homo sapiens	144-147
2454133-6	1988	Polarization measurements showed that in the presence of Ca2+ a rigid phosphatidic acid rich region and a more fluid phosphatidylcholine-rich region were formed.	Phosphatidylcholines	117-136	carbonic anhydrase 2	Homo sapiens	57-60
3198053-6	1988	The PA2 activity associated with normal spermatozoa exhibited a 60% decrease in activity after storage at -20 degrees C for 48 hr followed by a heating period of 10 min at 60 degrees C. Long-term storage of spermatozoa at -20 degrees C also resulted in a similar decrease in the deacylation of PC.	Phosphatidylcholines	294-296	phospholipase A2 group IB	Homo sapiens	4-7
2831902-0	1988	Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells.	Phosphatidylcholines	89-108	arginine vasopressin	Homo sapiens	18-29
2830903-0	1988	Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond.	Phosphatidylcholines	47-74	arginine vasopressin	Rattus norvegicus	0-11
2830903-6	1988	Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium.	Phosphatidylcholines	236-255	arginine vasopressin	Rattus norvegicus	93-104
2830903-11	1988	Further, collateral with vasopressin-induced phosphatidylcholine hydrolysis, the cellular release of arachidonic acid occurs.	Phosphatidylcholines	45-64	arginine vasopressin	Rattus norvegicus	25-36
2893798-4	1988	The limiting step in phosphatidylcholine biosynthesis was the formation of CDP-choline catalyzed by CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15) as monitored by the decrease in phosphocholine labeling following phospholipase C treatment of cells prelabeled with [3H]choline.	Phosphatidylcholines	21-40	cut like homeobox 1	Homo sapiens	75-78
3129527-5	1988	Therefore, phospholipase A2 activity was calculated as the rate of the release of arachidonic acid from phosphatidylcholine under the conditions used.	Phosphatidylcholines	104-123	phospholipase A2 group IB	Homo sapiens	11-27
3123482-2	1988	We have studied the phospholipase A2 activity in fractionated human neutrophils, employing labeled phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine as exogenous substrates.	Phosphatidylcholines	121-140	phospholipase A2 group IB	Homo sapiens	20-36
3342248-1	1988	The influence of variation of the phospholipid composition in model membranes composed of phosphatidylcholine and phosphatidylethanolamine on the hydrolysis of these phospholipids by rat liver mitochondrial phospholipase A2 was investigated.	Phosphatidylcholines	90-109	phospholipase A2 group IB	Rattus norvegicus	207-223
3365383-4	1988	After hexane extraction of lyophilized disks, PC is the major component of the fraction of lipids that remains associated with rhodopsin, followed by phosphatidylserine, while a large proportion of the phosphatidylethanolamine is removed.	Phosphatidylcholines	46-48	rhodopsin	Bos taurus	127-136
3365383-7	1988	VLCPUFA-containing PCs are the most highly concentrated species in the rhodopsin-associated lipid fraction.	Phosphatidylcholines	19-22	rhodopsin	Bos taurus	71-80
3342232-4	1988	In the presence of 1% CHAPS, hydrolysis of exogenous phosphatidylcholine was shown to be due to an initial phospholipase A2-type attack followed by a subsequent lysophospholipase-type attack.	Phosphatidylcholines	53-72	phospholipase A2 group IB	Rattus norvegicus	107-123
3342232-4	1988	In the presence of 1% CHAPS, hydrolysis of exogenous phosphatidylcholine was shown to be due to an initial phospholipase A2-type attack followed by a subsequent lysophospholipase-type attack.	Phosphatidylcholines	53-72	asparaginase	Rattus norvegicus	161-178
3123482-10	1988	Phosphatidylinositol was a better substrate for the plasma membrane enzyme, whereas phosphatidylcholine and phosphatidylethanolamine behaved as better substrates for intracellular organelle phospholipase A2 activities.	Phosphatidylcholines	84-103	phospholipase A2 group IB	Homo sapiens	190-206
3336410-0	1988	Prevention by choline of the depletion of membrane phosphatidylcholine by a cholinesterase inhibitor.	Phosphatidylcholines	51-70	butyrylcholinesterase	Homo sapiens	76-90
2974829-3	1988	In kinetic studies, all of the above proteases stimulated the deacylation of phosphatidylcholine (PC); in fresh spermatozoa, trypsin showed a higher activation potential than kallikrein or plasmin.	Phosphatidylcholines	77-96	kallikrein related peptidase 4	Homo sapiens	175-185
2974829-3	1988	In kinetic studies, all of the above proteases stimulated the deacylation of phosphatidylcholine (PC); in fresh spermatozoa, trypsin showed a higher activation potential than kallikrein or plasmin.	Phosphatidylcholines	77-96	plasminogen	Homo sapiens	189-196
3337803-3	1988	Protein 4.1 penetrated into monolayers of brain phosphatidylserine (PS) and egg phosphatidylcholine (PC), even above surface pressures of 30 mN/m.	Phosphatidylcholines	80-99	erythrocyte membrane protein band 4.1	Homo sapiens	0-11
2894457-2	1988	Previous studies have indicated that bradykinin stimulates arachidonic acid release in Swiss 3T3 cells by activating phospholipase A2 and by activating phosphatidylcholine-specific phospholipase C in CPAE cells.	Phosphatidylcholines	152-171	kininogen 1	Bos taurus	37-47
3349060-1	1988	13C NMR spectroscopy was used to probe the structural interactions between carboxyl-13C-enriched oleic acid (18:1) and rat liver fatty acid binding protein (FABP) and the partitioning of 18:1 between FABP and unilamellar phosphatidylcholine (PC) vesicles.	Phosphatidylcholines	221-240	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	157-161
3337718-4	1988	In addition, ATP is shown to inhibit, and phosphatidylcholine is shown to stimulate, 15-lipoxygenase, suggesting a regulatory role for these compounds in the lipoxygenation of arachidonic acid.	Phosphatidylcholines	42-61	arachidonate 15-lipoxygenase	Homo sapiens	85-100
3384576-14	1988	Phospholipase A2 detaches the fatty acid from the position of phosphatidyl choline, and the lysolecithin formed has a detergent effect that can produce membrane destabilization.	Phosphatidylcholines	62-82	phospholipase A2 group IB	Rattus norvegicus	0-16
2446664-4	1988	However, myelin basic protein was labeled 2-4-times more when bound to the acidic lipids phosphatidylglycerol, phosphatidylserine, phosphatidic acid, and cerebroside sulfate than when bound to phosphatidylethanolamine, or when in solution in the presence of phosphatidylcholine vesicles.	Phosphatidylcholines	258-277	myelin basic protein	Homo sapiens	9-29
3146672-0	1988	Influence of a beta-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung.	Phosphatidylcholines	78-97	amyloid beta precursor protein	Rattus norvegicus	13-19
2826503-2	1988	Initial phospholipid analysis by two-dimensional thin layer chromatography (2-D TLC) reveals a significant increase in the amount of 32P-labeled phosphatidylcholine in the Thy-1 capped membrane.	Phosphatidylcholines	145-164	thymus cell antigen 1, theta	Mus musculus	172-177
2826503-4	1988	Therefore, it is suggested that phosphatidylcholine may be involved in the organization and/or regulation of Thy-1 antigen redistribution.	Phosphatidylcholines	32-51	thymus cell antigen 1, theta	Mus musculus	109-122
2829843-2	1987	Reconstitution of the receptor kinase into leaky vesicles containing phosphatidylcholine and phosphatidylethanolamine (1:1, w/w) by detergent removal on Sephadex G-50 results in the complete loss of receptor kinase sensitivity to activation by insulin.	Phosphatidylcholines	69-88	insulin	Homo sapiens	244-251
20501314-5	1988	For the metabolism of phosphatidylcholine the measured enzymes were CTP: phosphocholine cytidylyltransferase and CDP-choline: diacylglycerol cholinephosphotransferase.	Phosphatidylcholines	22-41	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	68-108
3163212-3	1988	In addition, the increased synthesis of ara-CDP-choline associated with these high doses may serve as an alternate substrate for phosphatidyl choline synthesis, which may contribute to membrane fragility and cell lysis.	Phosphatidylcholines	129-149	cut like homeobox 1	Homo sapiens	44-47
3121598-5	1987	In mixed phospholipid vesicles containing PS and phosphatidylcholine in various molar ratios, the extent of PAI-1 activation was directly related to the PS content of the phospholipid membrane.	Phosphatidylcholines	49-68	serpin family E member 1	Homo sapiens	108-113
3126801-6	1987	Although apo A-I interacted spontaneously with DMPC at 25 degrees C, it was necessary to dilute mixed micellar solutions of sodium taurocholate (TC) and egg yolk phosphatidylcholine (EYPC) with apo A-I solutions to form apo A-I/EYPC mixed micelles.	Phosphatidylcholines	162-181	apolipoprotein A1	Homo sapiens	194-201
2829843-9	1987	These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles.	Phosphatidylcholines	221-240	insulin	Homo sapiens	57-64
3126801-6	1987	Although apo A-I interacted spontaneously with DMPC at 25 degrees C, it was necessary to dilute mixed micellar solutions of sodium taurocholate (TC) and egg yolk phosphatidylcholine (EYPC) with apo A-I solutions to form apo A-I/EYPC mixed micelles.	Phosphatidylcholines	162-181	apolipoprotein A1	Homo sapiens	194-201
2829843-9	1987	These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles.	Phosphatidylcholines	221-240	insulin	Homo sapiens	160-167
2959321-2	1987	The permeability of lipid bilayers to Co2+ and glucose was increased slightly by incorporation of the ATPase, and the permeability of mixed bilayers of phosphatidylethanolamine and phosphatidylcholine increased with increasing content of phosphatidylethanolamine both in the presence and absence of the ATPase.	Phosphatidylcholines	181-200	dynein axonemal heavy chain 8	Homo sapiens	303-309
2825797-6	1987	These activities co-purified during the entire purification procedure, indicating that the acid sphingomyelinase hydrolyses not only sphingomyelin but also the other two phospholipids, phosphatidylcholine and phosphatidylglycerol.	Phosphatidylcholines	185-204	sphingomyelin phosphodiesterase 1	Homo sapiens	91-112
3680298-1	1987	Phosphatidylethanolamine (PE) N-methyltransferase catalyzes the synthesis of phosphatidylcholine by the stepwise transfer of methyl groups from S-adenosylmethionine to the amino head group of PE.	Phosphatidylcholines	77-96	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	0-49
3689818-0	1987	Contamination of commercial phosphatidylcholine by phospholipase A.	Phosphatidylcholines	28-47	phospholipase A and acyltransferase 1	Homo sapiens	51-66
3427105-1	1987	Low-angle neutron scattering is used to study the binding of human prothrombin to small single-bilayer vesicles consisting of phosphatidylcholine and phosphatidylserine (1/1 w/w).	Phosphatidylcholines	126-145	coagulation factor II, thrombin	Homo sapiens	67-78
3315823-3	1987	Elevated phosphatidylcholine and reduced lysophosphatidylcholine fractions indicated impairment of cholesterol esterification by lecithin-cholesterol acyltransferase.	Phosphatidylcholines	9-28	lecithin-cholesterol acyltransferase	Homo sapiens	129-165
3676313-0	1987	Activity of bile-salt-stimulated human milk lipase in the presence of liposomes and mixed taurocholate-phosphatidylcholine micelles.	Phosphatidylcholines	103-122	carboxyl ester lipase	Homo sapiens	39-50
3676318-0	1987	Leakage from egg phosphatidylcholine vesicles induced by Ca2+ and alcohols.	Phosphatidylcholines	17-36	carbonic anhydrase 2	Homo sapiens	57-60
3676318-1	1987	The results shown in this paper indicate that the permeability properties of egg yolk phosphatidylcholine sonicated vesicles as detected by the leakage of carboxy fluorescein changes according to the Ca2+ content.	Phosphatidylcholines	86-105	carbonic anhydrase 2	Homo sapiens	200-203
3117799-9	1987	Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate.	Phosphatidylcholines	5-24	arginine vasopressin	Rattus norvegicus	184-195
3117799-9	1987	Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate.	Phosphatidylcholines	230-249	arginine vasopressin	Rattus norvegicus	184-195
3118953-1	1987	NADPH-cytochrome P-450 reductase, purified from bovine adrenocortical microsomes, was shown to bind in two different modes to liposomal membranes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine at a molar ratio of 5:3:1.	Phosphatidylcholines	158-177	cytochrome p450 oxidoreductase	Bos taurus	0-32
2445736-6	1987	In contrast, the membrane fraction from the transformants carrying PEM2 catalyzed the synthesis of phosphatidylcholine (PC) from PE, indicating that it contains all of the three methylation activities.	Phosphatidylcholines	99-118	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	67-71
2445736-6	1987	In contrast, the membrane fraction from the transformants carrying PEM2 catalyzed the synthesis of phosphatidylcholine (PC) from PE, indicating that it contains all of the three methylation activities.	Phosphatidylcholines	120-122	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	67-71
2445736-9	1987	The results of phospholipid composition analysis showed that the PEM1 transformant accumulated PMME whereas the PEM2 transformant contained a decreased amount of PC.	Phosphatidylcholines	162-164	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	112-116
2446313-9	1987	CAT activity in RDM-4 cells from mice injected with DNA entrapped in pH-insensitive immunoliposomes (containing phosphatidylcholine in place of phosphatidylethanolamine) was approximately one-fourth that in RDM-4 cells from mice injected with pH-sensitive immunoliposomes, indicating the superior delivery efficiency of the pH-sensitive liposomes.	Phosphatidylcholines	112-131	chloramphenicol acetyltransferase	Escherichia coli	0-3
3427069-2	1987	The phosphatidylcholine transfer protein from bovine liver has specific binding sites for the sn-1 and sn-2 acyl chains of the phosphatidylcholine molecule [Berkhout, T.A., Visser, A.J.	Phosphatidylcholines	4-23	solute carrier family 38 member 5	Bos taurus	103-107
3427069-2	1987	The phosphatidylcholine transfer protein from bovine liver has specific binding sites for the sn-1 and sn-2 acyl chains of the phosphatidylcholine molecule [Berkhout, T.A., Visser, A.J.	Phosphatidylcholines	127-146	solute carrier family 38 member 5	Bos taurus	103-107
3428670-3	1987	Pretreatment with the phospholipase A2 inhibitor, quinacrine, prevented the increases in mucosal phospholipase A2 activity and lysophosphatidylcholine/phosphatidylcholine ratio after ischaemia and morphological examinations revealed that the mucosa was then also protected against ischaemic injury.	Phosphatidylcholines	131-150	phospholipase A2 group IB	Rattus norvegicus	22-38
3125165-4	1987	On the other hand, liposomes composed of neutral phospholipids such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin showed little increases in permeability when incubated with TNF above pH 5.0.	Phosphatidylcholines	71-90	tumor necrosis factor	Mus musculus	196-199
3479781-3	1987	Bilirubin ditaurine (BR-DT), a water-soluble model compound of conjugated bilirubin, completely prevents the peroxyl radical-induced oxidation of phosphatidylcholine in either multilamellar liposomes or micelles.	Phosphatidylcholines	146-165	bromodomain testis associated	Homo sapiens	0-26
3117787-0	1987	Thyrotropin-releasing hormone and phorbol esters induce phosphatidylcholine synthesis in GH3 pituitary cells.	Phosphatidylcholines	56-75	thyrotropin releasing hormone	Rattus norvegicus	0-29
2447937-3	1987	On the other hand, gramicidin enhances the rate of cleavage of outer membrane layer phosphatidylcholine by phospholipase A2, which indicates changes in the packing of phosphatidylcholine following gramicidin binding.	Phosphatidylcholines	84-103	phospholipase A2 group IB	Homo sapiens	107-123
2447937-3	1987	On the other hand, gramicidin enhances the rate of cleavage of outer membrane layer phosphatidylcholine by phospholipase A2, which indicates changes in the packing of phosphatidylcholine following gramicidin binding.	Phosphatidylcholines	167-186	phospholipase A2 group IB	Homo sapiens	107-123
3117787-1	1987	Evidence for stimulation via protein kinase C. Phorbol esters have been shown to stimulate phosphatidylcholine synthesis via the CDP-choline pathway.	Phosphatidylcholines	91-110	cut-like homeobox 1	Rattus norvegicus	129-132
3117787-2	1987	The present study compares the effects of phorbol esters and thyrotropin-releasing hormone (TRH) on phosphatidylcholine metabolism in GH3 pituitary cells.	Phosphatidylcholines	100-119	thyrotropin releasing hormone	Rattus norvegicus	61-90
2820490-5	1987	(2) Spin-labeled lipophilic cations were synthesized and the binding to liposomes of egg phosphatidylcholine was examined.	Phosphatidylcholines	89-108	spindlin 1	Homo sapiens	4-8
3654657-0	1987	Binding of fluorescent-labeled phosphatidylcholine to rat liver nonspecific lipid transfer protein.	Phosphatidylcholines	31-50	sterol carrier protein 2	Rattus norvegicus	64-98
3120703-7	1987	It can be thus concluded that, in the release of arachidonic acid by antigen-stimulated mast cells, the phospholipase A2 pathway, in which phosphatidylcholine is hydrolysed, serves as the major one, the phospholipase C/diacylglycerol lipase pathway playing only a minor role.	Phosphatidylcholines	139-158	phospholipase A2 group IB	Rattus norvegicus	104-120
3651600-1	1987	The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes.	Phosphatidylcholines	4-23	phosphatidylcholine transfer protein	Bos taurus	51-55
3651600-1	1987	The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes.	Phosphatidylcholines	51-53	phosphatidylcholine transfer protein	Bos taurus	4-49
3620490-10	1987	The subcellular content of disaturated phosphatidylcholine (PC) appeared to correlate well with the activity of phospholipase A2 in the neonatal mitochondrial, microsomal and cytosolic fractions.	Phosphatidylcholines	60-62	phospholipase A2	Oryctolagus cuniculus	112-128
3681145-3	1987	Of all the examined liposomes prepared from cholesterol and various synthetic phosphatidylcholines, liposomes with dimyristoylphosphatidylcholine (DMPC) were found to be the most reactive in the LCAT reaction.	Phosphatidylcholines	78-98	lecithin-cholesterol acyltransferase	Homo sapiens	195-199
3655561-1	1987	The binding of phosphatidylcholine and cholesterol in model bile to human gallbladder mucin was studied by means of a rapid filtration binding assay and sucrose density gradient ultracentrifugation.	Phosphatidylcholines	15-34	LOC100508689	Homo sapiens	86-91
3631062-2	1987	PLase A2-induced conversion of phosphatidyl choline (PC) to lysophosphatidyl choline (L-PC) was associated with a marked increase in Na+ influx and Ca2+ uptake.	Phosphatidylcholines	31-51	phospholipase A2 group IB	Homo sapiens	0-8
3631062-2	1987	PLase A2-induced conversion of phosphatidyl choline (PC) to lysophosphatidyl choline (L-PC) was associated with a marked increase in Na+ influx and Ca2+ uptake.	Phosphatidylcholines	53-55	phospholipase A2 group IB	Homo sapiens	0-8
3663914-2	1987	It has been shown that the repair effect of phosphatidylcholine liposomes was manifested in vivo by normalization of phospholipid membrane composition, reduction in the degree of cytochrome P-450 inactivation, partial normalization of its hydroxylase activity and recovery of glucose-6-phosphatase activity.	Phosphatidylcholines	44-63	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	276-297
3655561-2	1987	Numerous low affinity binding sites for phosphatidylcholine and cholesterol were present on gallbladder mucin.	Phosphatidylcholines	40-59	LOC100508689	Homo sapiens	104-109
3655561-3	1987	Binding of phosphatidylcholine and cholesterol to mucin increased as a function of cholesterol saturation index.	Phosphatidylcholines	11-30	LOC100508689	Homo sapiens	50-55
3655561-5	1987	Proteolytic digestion also resulted in a 91% and 78% decrease, respectively, in the binding of phosphatidylcholine and cholesterol to mucin.	Phosphatidylcholines	95-114	LOC100508689	Homo sapiens	134-139
3655561-9	1987	These data indicate that highly purified human gallbladder mucin binds phosphatidylcholine and cholesterol in model bile.	Phosphatidylcholines	71-90	LOC100508689	Homo sapiens	59-64
2820405-2	1987	The highly purified reductase oxidized NADPH and generated superoxide when combined with partially purified cytochrome b559 in the presence of phosphatidylcholine.	Phosphatidylcholines	143-162	2,4-dienoyl-CoA reductase 1	Homo sapiens	39-44
2820405-2	1987	The highly purified reductase oxidized NADPH and generated superoxide when combined with partially purified cytochrome b559 in the presence of phosphatidylcholine.	Phosphatidylcholines	143-162	mitochondrially encoded cytochrome b	Homo sapiens	108-120
3475216-1	1987	Prostaglandin (PG) E1 was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL3) to low density lipoproteins (LDL).	Phosphatidylcholines	68-87	HDL3	Homo sapiens	149-153
3607074-9	1987	Experiments with exogenously added labeled phosphatidylcholines confirmed that chromaffin granule ghosts contain a phospholipase A2 activity (alkaline pH optimum).	Phosphatidylcholines	43-63	LOC104974671	Bos taurus	115-131
3607054-3	1987	Reduction of membrane phosphatidylcholine by phospholipase A2 resulted in a marked increase in the binding of the entire HDL3 particle and a relative decrease in preferential binding of [3H]cholesteryl linoleyl ether.	Phosphatidylcholines	22-41	LOC104974671	Bos taurus	45-61
3607054-3	1987	Reduction of membrane phosphatidylcholine by phospholipase A2 resulted in a marked increase in the binding of the entire HDL3 particle and a relative decrease in preferential binding of [3H]cholesteryl linoleyl ether.	Phosphatidylcholines	22-41	HDL3	Homo sapiens	121-125
3111472-2	1987	Negatively charged lipids, sulfatide and phosphatidylserine (PS), lowered the Km values of t-PA for plasminogen activation (sulfatide, 20-fold; PS, 6-fold), whereas neutral lipid phosphatidylcholine raised the Km.	Phosphatidylcholines	179-198	plasminogen activator, tissue type	Homo sapiens	91-95
2959316-4	1987	The fusion of liposomes containing Fc gamma 2bR, which was obtained as phosphatidylcholine (PC) binding protein as previously described, with the cyc- membrane preparations resulted in the marked suppression of membrane adenylate cyclase, whereas the fusion of liposomes containing Fc gamma 2a, which was obtained as IgG-binding protein, led to about a 2.7-fold increase.	Phosphatidylcholines	71-90	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	146-149
2959316-4	1987	The fusion of liposomes containing Fc gamma 2bR, which was obtained as phosphatidylcholine (PC) binding protein as previously described, with the cyc- membrane preparations resulted in the marked suppression of membrane adenylate cyclase, whereas the fusion of liposomes containing Fc gamma 2a, which was obtained as IgG-binding protein, led to about a 2.7-fold increase.	Phosphatidylcholines	92-94	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	146-149
3597406-3	1987	All ester PCs were good acyl donors for the transesterification of cholesterol catalyzed by human lecithin-cholesterol acyltransferase except DPhPC, which showed no reactivity.	Phosphatidylcholines	10-13	lecithin-cholesterol acyltransferase	Homo sapiens	98-134
3593755-5	1987	Emulsions containing saturated phosphatidylcholines at temperatures below their melting points were poor substrates for lipoprotein lipase, compared with those stabilized by mixed chain phosphatidylcholines.	Phosphatidylcholines	31-51	lipoprotein lipase	Rattus norvegicus	120-138
2958081-5	1987	It was also found that the degradation of liposomal phosphatidylcholine by soluble snake venom PLA2 is inversely proportional to the solvent viscosity.	Phosphatidylcholines	52-71	phospholipase A2 group IB	Homo sapiens	95-99
3038645-2	1987	Although phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine also increased insulin receptor autophosphorylation, only phosphatidylinositol (PtdIns) stimulated to a similar extent as the phospholipid mixture.	Phosphatidylcholines	9-28	insulin receptor	Homo sapiens	93-109
3116710-5	1987	Apparently, AD6 inhibits the release of arachidonic acid from phosphatidylinositol and choline phosphoglycerides which are the main sources of the substrate for the synthesis of prostaglandins and thromboxanes.	Phosphatidylcholines	87-112	AD6	Homo sapiens	12-15
3625042-0	1987	Synthesis of a naphthylvinyl-labeled glycerol ether analog of phosphatidylcholine and its use in the assay of phospholipase A2.	Phosphatidylcholines	62-81	phospholipase A2 group IB	Homo sapiens	110-126
3593706-6	1987	Polymerized DPL vesicles uniquely bound a protein of about 53 kDa which was not bound to other types of phosphatidylcholine liposomes.	Phosphatidylcholines	104-123	prion like protein doppel	Homo sapiens	12-15
3591946-8	1987	Kinetic analysis of phosphatidylcholine-stabilized triglyceride emulsions revealed a significant decrease in immobilized enzyme Km and an increase in Vmax when the emulsion was supplemented with apoE.	Phosphatidylcholines	20-39	apolipoprotein E	Homo sapiens	195-199
3107616-0	1987	Properties of discoidal complexes of human apolipoprotein A-I with phosphatidylcholines containing various fatty acid chains.	Phosphatidylcholines	67-87	apolipoprotein A1	Homo sapiens	43-61
3107616-1	1987	In this study we demonstrate that apolipoprotein A-I determined the common size classes of discoidal particles formed with numerous phosphatidylcholines, and with ether analogs of phosphatidylcholines.	Phosphatidylcholines	132-152	apolipoprotein A1	Homo sapiens	34-52
3107616-1	1987	In this study we demonstrate that apolipoprotein A-I determined the common size classes of discoidal particles formed with numerous phosphatidylcholines, and with ether analogs of phosphatidylcholines.	Phosphatidylcholines	180-200	apolipoprotein A1	Homo sapiens	34-52
3584136-7	1987	In incubations designed to simulate in vivo conditions, no more than 15% of the disappearance of 16:1-16:1 PC, one of the most rapidly cleared PCs, was due to the action of LCAT.	Phosphatidylcholines	143-146	lecithin cholesterol acyltransferase	Rattus norvegicus	173-177
3032270-0	1987	Effects of vasopressin on the synthesis of phosphatidylethanolamines and phosphatidylcholines by isolated rat hepatocytes.	Phosphatidylcholines	73-93	arginine vasopressin	Rattus norvegicus	11-22
3108322-5	1987	Analysis of tissue phosphatidylcholine by mass spectrometric techniques revealed metabolism of PAF to 1-0-hexadecyl-2-arachidonoyl-GPC, which represented 20-23% of the administered radiolabeled hexadecyl-PAF.	Phosphatidylcholines	19-38	PCNA clamp associated factor	Rattus norvegicus	95-98
3032270-1	1987	The effect of vasopressin on the biosynthesis of phosphatidylcholines and phosphatidylethanolamines was investigated in freshly isolated rat hepatocytes in suspension.	Phosphatidylcholines	49-69	arginine vasopressin	Rattus norvegicus	14-25
3032270-2	1987	Treatment of hepatocytes with vasopressin inhibits the incorporation of [Me-14C]choline into phosphatidylcholines in a dose-dependent manner.	Phosphatidylcholines	93-113	arginine vasopressin	Rattus norvegicus	30-41
3032270-5	1987	In contrast with the inhibitory effect of vasopressin on the synthesis of phosphatidylcholines, this hormone stimulates the incorporation of [1,2-14C]ethanolamine into phosphatidylethanolamines in a dose-dependent manner.	Phosphatidylcholines	74-94	arginine vasopressin	Rattus norvegicus	42-53
3104321-3	1987	At pH values below about 5, TNF bound to phospholipid liposomes composed of mixtures of phosphatidyl-serine and phosphatidylcholine in molar ratios of 2:1 and 1:2 and caused rapid release of calcein.	Phosphatidylcholines	112-131	tumor necrosis factor	Homo sapiens	28-31
3113456-8	1987	Diacylglycerols were not highly labelled and the action of phospholipase A2 on labelled phosphatidylcholine was indicated.	Phosphatidylcholines	88-107	phospholipase A2 group IB	Rattus norvegicus	59-75
3032677-0	1987	De novo CDP-choline-dependent glycerophosphorylcholine synthesis and its involvement as an intermediate in phosphatidylcholine synthesis.	Phosphatidylcholines	107-126	cut like homeobox 1	Homo sapiens	8-11
3032677-1	1987	The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver.	Phosphatidylcholines	216-235	cut like homeobox 1	Homo sapiens	16-19
3598396-10	1987	However, the hepatic lipase of postheparin plasma had similar activity towards the two phosphatidylcholine species.	Phosphatidylcholines	87-106	lipase C, hepatic type	Bos taurus	13-27
3598396-12	1987	Antiserum to hepatic lipase inhibited the postheparin plasma hydrolysis of phosphatidylethanolamine and 3H-labeled phosphatidylcholine by about 60%, but the 14C-labeled phosphatidylcholine by only 27%.	Phosphatidylcholines	115-134	lipase C, hepatic type	Bos taurus	13-27
3549256-7	1987	On the other hand, as reported previously, insulin and cortisol, in combination, stimulated phosphatidylcholine synthesis.	Phosphatidylcholines	92-111	insulin	Homo sapiens	43-50
3828337-4	1987	The binding site for the sn-2 fatty acyl chain was investigated by incorporating in the transfer protein either phosphatidylinositol or phosphatidylcholine carrying a parinaroyl-chain attached at the sn-2 position.	Phosphatidylcholines	136-155	solute carrier family 38 member 5	Bos taurus	25-29
3828337-5	1987	Time-resolved fluorescence spectroscopy revealed that the sn-2 fatty acyl chains for both phospholipids in the lipid-protein complex were completely immobilized (i.e., rotational correlation times of 17.4 ns for phosphatidylcholine and 16.3 ns for phosphatidylinositol).	Phosphatidylcholines	212-231	solute carrier family 38 member 5	Bos taurus	58-62
3032300-3	1987	Phosphatidylcholine protective action is also manifested in an increase in the activity of glucose-6-phosphatase, a microsomal marker enzyme, up to its control level and in a 20% reduced rate of cytochrome P-450 inactivation.	Phosphatidylcholines	0-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	91-112
3032300-3	1987	Phosphatidylcholine protective action is also manifested in an increase in the activity of glucose-6-phosphatase, a microsomal marker enzyme, up to its control level and in a 20% reduced rate of cytochrome P-450 inactivation.	Phosphatidylcholines	0-19	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	195-211
3032677-1	1987	The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver.	Phosphatidylcholines	216-235	cut like homeobox 1	Homo sapiens	75-78
3566802-0	1987	Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2.	Phosphatidylcholines	47-66	phospholipase A2 group IB	Homo sapiens	81-97
3829397-1	1987	Phospholipase A (PLA) activity was measured with a semi-automated photometric test system that is based on liberation of fatty acids from phosphatidylcholine by phospholipases A1 (EC 3.1.1.32) and A2 (EC 3.1.1.4).	Phosphatidylcholines	138-157	phospholipase A and acyltransferase 1	Homo sapiens	0-15
3829397-1	1987	Phospholipase A (PLA) activity was measured with a semi-automated photometric test system that is based on liberation of fatty acids from phosphatidylcholine by phospholipases A1 (EC 3.1.1.32) and A2 (EC 3.1.1.4).	Phosphatidylcholines	138-157	phospholipase A and acyltransferase 1	Homo sapiens	17-20
3112131-4	1987	The loss of [3H]arachidonate radioactivity from phosphatidylcholine was almost equivalent to the increase in released [3H]arachidonic acid, suggesting the hydrolysis of phosphatidylcholine by phospholipase A2.	Phosphatidylcholines	169-188	phospholipase A2 group IB	Homo sapiens	192-208
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	37-56	gastrin releasing peptide	Homo sapiens	0-8
3104334-0	1987	Reaction of discoidal complexes of apolipoprotein A-I and various phosphatidylcholines with lecithin cholesterol acyltransferase.	Phosphatidylcholines	66-86	lecithin-cholesterol acyltransferase	Homo sapiens	92-128
3545832-5	1987	The interaction of the side chains of Trp1 and Trp3 residues of alpha-mating factor with the hydrophobic interior of the bilayer contributes to the binding of this peptide with the phosphatidylcholine bilayer.	Phosphatidylcholines	181-200	phosphoribosylanthranilate isomerase TRP1	Saccharomyces cerevisiae S288C	38-42
3545832-5	1987	The interaction of the side chains of Trp1 and Trp3 residues of alpha-mating factor with the hydrophobic interior of the bilayer contributes to the binding of this peptide with the phosphatidylcholine bilayer.	Phosphatidylcholines	181-200	bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase	Saccharomyces cerevisiae S288C	47-51
3545832-6	1987	The conformation of des-Trp1-alpha-mating-factor [(2-13)peptide] in the membrane-bound state has been found to be similar to that of (1-13)peptide from the analysis of transferred nuclear Overhauser effects in the presence of mixed vesicles of perdeuterated phosphatidylcholine and perdeuterated phosphatidylserine.	Phosphatidylcholines	258-277	phosphoribosylanthranilate isomerase TRP1	Saccharomyces cerevisiae S288C	24-28
2437135-4	1987	The detergent-extracted HABP from SV-3T3 membranes was reconstituted into the membrane of lipid vesicles, which were formed by addition of exogenous phosphatidylcholine and cholic acid to the extracts followed by removal of detergent by dialysis against 0.02 M Tris pH 8.0 in the presence of protease inhibitors.	Phosphatidylcholines	149-168	hyaluronic acid binding protein 2	Mus musculus	24-28
3559272-4	1987	The activities of both phospholipase A2 and C were assayed in each sample using phosphatidylcholine and phosphatidylinositol, respectively, as substrates.	Phosphatidylcholines	80-99	phospholipase A2 group IB	Homo sapiens	23-39
3549734-3	1987	This stimulatory protein was stable for several months when frozen at -70 degrees C. The purified protein selectively stimulated phospholipase A2 when phosphatidylcholine was used as a substrate but had no effect on phospholipase A2 activity when phosphatidylethanolamine was used as a substrate.	Phosphatidylcholines	151-170	phospholipase A2 group IB	Homo sapiens	129-145
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	237-256	gastrin releasing peptide	Homo sapiens	129-137
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	258-260	gastrin releasing peptide	Homo sapiens	0-8
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	258-260	gastrin releasing peptide	Homo sapiens	129-137
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	37-56	gastrin releasing peptide	Homo sapiens	129-137
3558493-1	1987	Stimulation was blocked by the bombesin receptor antagonist, [D-Arg1, D-Pro2, D-Trp7,9, Leu11] substance P, indicating that the effects on both PI and PC were mediated through the same receptor.	Phosphatidylcholines	151-153	gastrin releasing peptide	Homo sapiens	31-39
3558493-0	1987	Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C. Bombesin caused a marked stimulation of 32Pi into phosphatidylinositol (PI), with no apparent lag, and into phosphatidylcholine (PC), after a lag of about 20 min.	Phosphatidylcholines	237-256	gastrin releasing peptide	Homo sapiens	0-8
3029085-4	1987	The two cholinephosphotransferases that catalyze the biosynthesis of phosphatidylcholine and PAF have similar Mg2+ or Mn2+ requirements and are inhibited by Ca2+.	Phosphatidylcholines	69-88	PCNA clamp associated factor	Rattus norvegicus	93-96
3029069-2	1987	Thrombomodulin was incorporated into vesicles ranging from neutral (100% phosphatidylcholine) to highly charged (30% phosphatidylserine and 70% phosphatidylcholine).	Phosphatidylcholines	73-92	thrombomodulin	Oryctolagus cuniculus	0-14
3099849-5	1987	Parallel to the liberation process, phosphatidylcholine underwent a rapid decrease of radioactivity with both agonists, suggesting the involvement of a Ca2+-dependent phospholipase A2.	Phosphatidylcholines	36-55	phospholipase A2 group V	Homo sapiens	152-183
3801511-5	1987	Whereas the snake venom phospholipase A2 preferred phosphatidylcholine as a substrate, the other phospholipases A2 preferred acidic phospholipids in the order monomethylester greater than or equal to glycerol greater than or equal to serine.	Phosphatidylcholines	51-70	LOC104974671	Bos taurus	24-40
3029069-2	1987	Thrombomodulin was incorporated into vesicles ranging from neutral (100% phosphatidylcholine) to highly charged (30% phosphatidylserine and 70% phosphatidylcholine).	Phosphatidylcholines	144-163	thrombomodulin	Oryctolagus cuniculus	0-14
3102469-4	1987	At high Ca2+ concentrations, phosphatidylcholine and diacylphosphatidylethanolamine were hydrolyzed after stimulation with collagen, and phosphatidylserine and alkenylacylphosphatidylethanolamine were degraded after stimulation with both thrombin and collagen.	Phosphatidylcholines	29-48	coagulation factor II, thrombin	Homo sapiens	238-246
3029069-4	1987	Incorporation of thrombomodulin into phosphatidylcholine, with or without phosphatidylserine, alters the Ca2+ concentration dependence of protein C activation.	Phosphatidylcholines	37-56	thrombomodulin	Oryctolagus cuniculus	17-31
3029069-8	1987	Incorporation of thrombomodulin into pure phosphatidylcholine vesicles reduces the Km for protein C from 7.6 +/- 2 to 0.7 +/- 0.2 microM.	Phosphatidylcholines	42-61	thrombomodulin	Oryctolagus cuniculus	17-31
3029069-11	1987	The Km for protein C observed on endothelial cells is more similar to the Km observed when thrombomodulin (TM) is incorporated into pure phosphatidylcholine vesicles than into negatively charged vesicles, suggesting that the protein C-binding site on endothelial cells does not involve negatively charged phospholipids.	Phosphatidylcholines	137-156	thrombomodulin	Oryctolagus cuniculus	91-105
3572249-0	1987	Relation of lung fatty acid binding protein to the biosynthesis of pulmonary phosphatidic acid and phosphatidylcholine.	Phosphatidylcholines	99-118	glutamic-oxaloacetic transaminase 2	Homo sapiens	17-43
3828111-8	1987	The results suggest the possibility that changes in the levels of liver CTP may play a role in regulation of the cytidine pathway of liver phosphatidylcholine synthesis but not of phosphatidylethanolamine synthesis, because the latter pathway appears to be tightly controlled at the ethanolaminephosphotransferase step.	Phosphatidylcholines	139-158	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	72-75
3818590-6	1987	In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome.	Phosphatidylcholines	233-252	AT695_RS01930	Staphylococcus aureus	26-31
3818590-6	1987	In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome.	Phosphatidylcholines	233-252	AT695_RS01930	Staphylococcus aureus	172-177
3818596-3	1987	In the final purification step, partially purified CETP is incubated with a synthetic lipid emulsion consisting of phosphatidylcholine, triglyceride, and fatty acid, and the bound activity, which elutes in the void volume, is separated from nonbound proteins by gel filtration on Sepharose 4B.	Phosphatidylcholines	115-134	cholesteryl ester transfer protein	Homo sapiens	51-55
3107565-4	1987	When washed human platelets were stimulated by thrombin or A23187, the amount of PEP monitored by optical density was significantly decreased in consort with phosphatidylcholine (PC), indicating an active participation of PEP in the liberation of AA.	Phosphatidylcholines	158-177	coagulation factor II, thrombin	Homo sapiens	47-55
3107565-4	1987	When washed human platelets were stimulated by thrombin or A23187, the amount of PEP monitored by optical density was significantly decreased in consort with phosphatidylcholine (PC), indicating an active participation of PEP in the liberation of AA.	Phosphatidylcholines	179-181	coagulation factor II, thrombin	Homo sapiens	47-55
3805022-2	1987	The hydrophobicity of ligatin is also reflected by its ability to interpolate into the phosphatidylcholine bilayer as shown by a concentration-dependent change in membrane conductance.	Phosphatidylcholines	87-106	ligatin	Homo sapiens	22-29
3104714-7	1987	Thus, HPLC methodology indicates that arachidonoyl-containing molecular species of phosphatidylcholine and phosphatidylethanolamine are the major source of arachidonic acid in thrombin-stimulated human platelets, while certain ether phospholipid molecular species become enriched in arachidonate.	Phosphatidylcholines	83-102	coagulation factor II, thrombin	Homo sapiens	176-184
3801467-1	1987	The localization of the effects of DDT (5-50 mol%) addition on the acyl chain dynamics in unilamellar vesicles of two phosphatidylcholines (DPPC and egg PC) has been investigated by steady-state fluorescence polarization of a series of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12 and 16) whose fluorophore is located at a graded series of depths from the surface to the centre of the bilayer.	Phosphatidylcholines	118-138	D-dopachrome tautomerase	Homo sapiens	35-38
3793726-5	1987	First-order decreases in cholesterol esterase activity effected by compound 1 or 2 are also observed in the presence of taurocholate/phosphatidylcholine micelles.	Phosphatidylcholines	133-152	carboxyl ester lipase	Homo sapiens	25-45
3025201-1	1987	Light stimulates phospholipase A2 activity in rod outer segments (ROS) of bovine retina as measured by the liberation of arachidonate from phosphatidylcholine, in in vitro assays of dark-adapted ROS.	Phosphatidylcholines	139-158	LOC104974671	Bos taurus	17-33
3024736-4	1987	Angiotensin II also decreased the 3H radioactivity of PIP slightly only at 15 s and increased that of phosphatidic acid after 15 s, with no significant effect upon the labelings of phosphatidylinositol (PI), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) within 1 min.	Phosphatidylcholines	229-231	angiotensinogen	Rattus norvegicus	0-14
3790605-1	1987	Evidence is provided in this paper to indicate that hydrolysis of exogenously added phosphatidylethanolamine and phosphatidylcholine by the membrane-bound phospholipase A2 from rat-liver mitochondria is preceded by association of the substrates with the membranes.	Phosphatidylcholines	113-132	phospholipase A2 group IB	Rattus norvegicus	155-171
3032160-2	1987	This enhanced synthesis of phosphatidylcholine was accompanied by an increased conversion of choline phosphate into CDP-choline.	Phosphatidylcholines	27-46	cut-like homeobox 1	Rattus norvegicus	116-119
3028505-1	1987	Temperature relationship was measured of ESR spectra of spin probes--derivatives of fatty acids whose nitroxyl fragments are incorporated into surface and inner layers of phosphatidylcholine liposomes (T = 180-260 K), as well as of the probe in model ethanol solution (T = 110-220 K).	Phosphatidylcholines	171-190	spindlin 1	Homo sapiens	56-60
3593300-3	1987	Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC).	Phosphatidylcholines	191-210	phospholipase A2 group IB	Homo sapiens	51-67
3593300-3	1987	Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC).	Phosphatidylcholines	212-214	phospholipase A2 group IB	Homo sapiens	51-67
3535899-9	1986	These findings indicate that the insulin secretagogue D-glucose induces phospholipid hydrolysis in islets and suggest that PC may be the major source of free arachidonate which accumulates in glucose-stimulated islets.	Phosphatidylcholines	123-125	insulin	Homo sapiens	33-40
20501174-9	1987	Since both of these compounds are used in the biosynthesis of phosphatidylcholine, both may be involved in the long-term effects of the CDP-choline.	Phosphatidylcholines	62-81	cut-like homeobox 1	Rattus norvegicus	136-139
16665217-1	1987	Evidence for the involvement of Ca(2+) and calmodulin in the regulation of phospholipid breakdown by microsomal membranes from bean cotyledons has been obtained by following the formation of radiolabeled degradation products from [U-(14)C]phosphatidylcholine.	Phosphatidylcholines	239-258	calmodulin 1	Homo sapiens	43-53
2963203-2	1987	The SR protein is solubilized with the zwitterionic detergent CHAPS in the presence of added 5-mM phosphatidylcholine and 20% glycerol, which stabilize the reconstitutable Ca2+ transport activity.	Phosphatidylcholines	98-117	RNA binding protein with serine rich domain 1	Homo sapiens	4-14
3039692-4	1987	On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine.	Phosphatidylcholines	31-50	proenkephalin	Rattus norvegicus	106-116
3039692-4	1987	On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine.	Phosphatidylcholines	186-205	proenkephalin	Rattus norvegicus	106-116
3039692-4	1987	On treatment of membranes with phosphatidylcholine-hydrolyzing phospholipase C, specific [D-Ala2,-D-Leu5] enkephalin binding was drastically decreased with the progressive hydrolysis of phosphatidylcholine in the rat brain membranes, and specific binding was completely lost after 81% hydrolysis of phosphatidylcholine.	Phosphatidylcholines	186-205	proenkephalin	Rattus norvegicus	106-116
3801440-5	1986	However, binding of C5b-6 to membranes required phosphatidylglycerol or phosphatidic acid produced from egg phosphatidylcholine while binding of C5b-6 to phosphatidylcholine, phosphatidylserine, or phosphatidylinositol was undetectable.	Phosphatidylcholines	108-127	complement C5	Homo sapiens	20-23
2947479-9	1986	The inhibition of Na+-Ca2+ exchange caused by phospholipase A2 digestion in the control heart sarcolemma was completely reversible by the addition of phosphatidylcholine (0.1 mM).	Phosphatidylcholines	150-169	phospholipase A2 group IB	Canis lupus familiaris	46-62
3032217-0	1986	The relative degradation of [14C]eicosapentaenoyl and [3H]arachidonoyl species of phosphatidylinositol and phosphatidylcholine in thrombin-stimulated human platelets.	Phosphatidylcholines	107-126	coagulation factor II, thrombin	Homo sapiens	130-138
3032217-4	1986	The [3H]AA/[14C]EPA dpm ratio for the loss of radioactivity from phosphatidylcholine (PC) upon thrombin stimulation, as well as that in the residual PC remaining after stimulation, was similar to that in PC in the resting platelets.	Phosphatidylcholines	86-88	coagulation factor II, thrombin	Homo sapiens	95-103
2948560-1	1986	The ATPase activity of the (Ca2+-Mg2+)-ATPase reconstituted into bilayers of phosphatidylcholines depends on the fatty acyl chain length of the phospholipids.	Phosphatidylcholines	77-97	dynein axonemal heavy chain 8	Homo sapiens	4-10
2948560-1	1986	The ATPase activity of the (Ca2+-Mg2+)-ATPase reconstituted into bilayers of phosphatidylcholines depends on the fatty acyl chain length of the phospholipids.	Phosphatidylcholines	77-97	dynein axonemal heavy chain 8	Homo sapiens	39-45
3778900-3	1986	From all substances tested (isoproterenol, phenylephrine, adrenalin, histamine, angiotensin II, dansylcadaverine, propranolol) only isoproterenol and adrenalin slightly decreased total amount of phosphatidylcholine (PC).	Phosphatidylcholines	195-214	angiotensinogen	Homo sapiens	80-94
3096314-0	1986	Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phospholipase C in mammalian cells.	Phosphatidylcholines	73-92	LOC100009319	Oryctolagus cuniculus	39-54
3768366-0	1986	The intramembranous domains of lipophilin in phosphatidylcholine vesicles are similar to those in the myelin membrane.	Phosphatidylcholines	45-64	proteolipid protein 1	Homo sapiens	31-41
3562319-6	1986	CD reveals that BK also interacts with acidic lipids which bear a net electrical charge (e.g., cerebroside sulfate and phosphatidyl inositol) but not with lipids bearing no net charge (e.g., cerebroside and phosphatidyl choline).	Phosphatidylcholines	207-227	kininogen 1	Homo sapiens	16-18
3790533-7	1986	Lysosomal phospholipase A from rat kidney hydrolyzes the sn-1 acyl group of phosphatidylcholine, does not require divalent cations for full activity, and is not inhibited by ethylenediaminetetraacetic acid.	Phosphatidylcholines	76-95	phospholipase A and acyltransferase 1	Rattus norvegicus	10-25
2433381-1	1986	A photometric method for the determination of phospholipase A is described, in which fatty acids are liberated from phosphatidylcholine and measured by a discontinuous enzymatic test.	Phosphatidylcholines	116-135	phospholipase A and acyltransferase 1	Homo sapiens	46-61
2434471-3	1986	Purified PLA2 had absolute 2-acyl specificity, and hydrolyzed phosphatidylcholine with optimal activity at pH 7.5-8.0 and phosphatidylethanolamine with optimal activity at pH 7.0.	Phosphatidylcholines	62-81	phospholipase A2 group IB	Homo sapiens	9-13
3768409-4	1986	The prothrombinase activity of resting, non-activated platelets, lysed platelets and vesicles composed of phosphatidylserine and phosphatidylcholine at different molar ratios is inhibited by beta 2-glycoprotein-I in a dose-dependent manner.	Phosphatidylcholines	129-148	coagulation factor X	Homo sapiens	4-18
3096314-0	1986	Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phospholipase C in mammalian cells.	Phosphatidylcholines	73-92	LOC100009319	Oryctolagus cuniculus	104-119
3756214-1	1986	The phosphatidylcholine (PC) component of liposomes was structurally modified by replacing its C-1, or both C-1 and C-2, ester linkage(s) with an ether and/or carbamyl bond(s) or by changing its steric configuration.	Phosphatidylcholines	4-23	complement C2	Rattus norvegicus	116-119
3531198-8	1986	In the presence of 50 microM phospholipid vesicles (25% phosphatidylserine/75% phosphatidylcholine; mole/mole), the Km is 0.34 microM and the Vmax is 7.1 mumol of prothrombin activated per min/mg of venom.	Phosphatidylcholines	79-98	coagulation factor II, thrombin	Bos taurus	163-174
3756205-0	1986	Fatty acyl chain specificity of phosphatidylcholine hydrolysis catalyzed by lipoprotein lipase.	Phosphatidylcholines	32-51	lipoprotein lipase	Homo sapiens	76-94
3756205-9	1986	These data are consistent with a model for activation of lipoprotein lipase in which residues 56-79 bind to lipoprotein lipase and alter the interaction of the sn-2 acyl chain of the phosphatidylcholine (PC) substrate or the lysoPC product within the activated state complex.	Phosphatidylcholines	183-202	lipoprotein lipase	Homo sapiens	57-75
3756205-9	1986	These data are consistent with a model for activation of lipoprotein lipase in which residues 56-79 bind to lipoprotein lipase and alter the interaction of the sn-2 acyl chain of the phosphatidylcholine (PC) substrate or the lysoPC product within the activated state complex.	Phosphatidylcholines	204-206	lipoprotein lipase	Homo sapiens	57-75
3756214-1	1986	The phosphatidylcholine (PC) component of liposomes was structurally modified by replacing its C-1, or both C-1 and C-2, ester linkage(s) with an ether and/or carbamyl bond(s) or by changing its steric configuration.	Phosphatidylcholines	25-27	complement C2	Rattus norvegicus	116-119
3741864-2	1986	Cytochrome b5 becomes firmly bound to the membrane and at the same time lysophosphatidylcholine is acylated by acyltransferases of the endoplasmic reticulum and converted into the membrane component phosphatidylcholine.	Phosphatidylcholines	76-95	cytochrome b5 type A	Homo sapiens	0-13
3815624-0	1986	Pr3+ transport across phosphatidylcholine vesicles mediated by open crown synthetic ionophores.	Phosphatidylcholines	22-41	proteinase 3	Homo sapiens	0-3
3815624-1	1986	Pr3+ transport experiments, varying temperature and concentration, show that open crown synthetic polyethers (podands) mediate Pr3+ translocation across phosphatidylcholine vesicles by a carrier mechanism.	Phosphatidylcholines	153-172	proteinase 3	Homo sapiens	0-3
3815624-1	1986	Pr3+ transport experiments, varying temperature and concentration, show that open crown synthetic polyethers (podands) mediate Pr3+ translocation across phosphatidylcholine vesicles by a carrier mechanism.	Phosphatidylcholines	153-172	proteinase 3	Homo sapiens	127-130
3781738-3	1986	The binding of tritiated Leu-enkephalin to phosphatidylserine and phosphatidylcholine vesicles, both unmodified and modified by the incorporation of free fatty acid, has been studied by steric exclusion chromatography, ultraviolet difference spectroscopy and fluorescence anisotropy.	Phosphatidylcholines	66-85	prodynorphin	Homo sapiens	25-39
3026352-4	1986	Experiments using double (3H/14C) labelling, to distinguish pools with different rates of turnover, suggest the major pool of arachidonic acid used for synthesis of lipoxygenase metabolites turns over more slowly than arachidonic acid in diacylglycerol, but at about the same rate as arachidonic acid esterified in phosphatidylcholine or phosphatidylinositol.	Phosphatidylcholines	315-334	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	165-177
3026338-3	1986	Reconstitution of thrombomodulin into phospholipid vesicles containing anionic phospholipids resulted in an increased rate of activation of protein C. Cardiolipin and vesicles containing phosphatidylcholine/phosphatidylserine (1:1, w/w) were the most effective.	Phosphatidylcholines	187-206	thrombomodulin	Homo sapiens	18-32
2943317-1	1986	The (Ca2+ + Mg2+)-ATPase purified from rabbit muscle sarcoplasmic reticulum has been reconstituted into a series of phosphatidylcholines in the liquid crystalline phase.	Phosphatidylcholines	116-136	plasma membrane calcium-transporting ATPase 1	Oryctolagus cuniculus	5-24
3020142-5	1986	Angiotensin II (0.25 nmol/l to 0.25 mumol/l) highly significantly (P less than 0.01) stimulated aldosterone and corticosterone outputs, [32P] incorporation into phosphatidic acid and phosphatidylinositol (but not into phosphatidylcholine) and the production of the three [3H]inositol phosphates.	Phosphatidylcholines	218-237	angiotensinogen	Rattus norvegicus	0-14
3094578-3	1986	This paper addresses the validity of this assumption on the basis of the examination of the state of self-association and binding properties with egg yolk phosphatidylcholine small unilamellar vesicles of native and iodinated apolipoprotein A-I (apoA-I).	Phosphatidylcholines	155-174	apolipoprotein A1	Homo sapiens	246-252
3730428-0	1986	Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed.	Phosphatidylcholines	209-228	phospholipase A2 group IB	Homo sapiens	55-71
3733728-3	1986	Leukotriene D4 treatment resulted in a dose-dependent, stereospecific increase in phospholipase A2 activity with phosphatidylcholine as a substrate.	Phosphatidylcholines	113-132	phospholipase A2, group IB, pancreas	Mus musculus	82-98
3015212-1	1986	Gastric (H+ + K+)-ATPase was reconstituted into artificial phosphatidylcholine/cholesterol liposomes by means of a freeze-thaw-sonication technique.	Phosphatidylcholines	59-78	dynein axonemal heavy chain 8	Homo sapiens	18-24
3730428-0	1986	Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed.	Phosphatidylcholines	209-228	phospholipase A2 group IB	Homo sapiens	78-94
3730428-0	1986	Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed.	Phosphatidylcholines	230-232	phospholipase A2 group IB	Homo sapiens	55-71
3730428-0	1986	Glucose transport into human erythrocytes treated with phospholipase A2 or C. Phospholipase A2 induced crenation of human erythrocytes and decreased glucose transport activity (influx rate) by 40% when 51% of phosphatidylcholine (PC) in the membrane was hydrolyzed.	Phosphatidylcholines	230-232	phospholipase A2 group IB	Homo sapiens	78-94
3089288-2	1986	Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate.	Phosphatidylcholines	126-145	LOC104974671	Bos taurus	26-42
3021886-2	1986	Fifteen seconds following thrombin addition (15 U/5 X 10(9) platelets), phosphatidylcholine lost 11.8 nmol of arachidonate and phosphatidylethanolamine lost 10.5 nmol.	Phosphatidylcholines	72-91	coagulation factor II, thrombin	Homo sapiens	26-34
3089288-2	1986	Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate.	Phosphatidylcholines	147-149	LOC104974671	Bos taurus	26-42
3718986-6	1986	In cells pre-treated with NaNO2 to convert hemoglobin to methemoglobin, t-butyl hydroperoxide reduces [9,10-3H]oleic acid incorporation into phosphatidylcholine by erythrocytes but does not stimulate [9,10-3H]oleic acid incorporation into phosphatidylethanolamine.	Phosphatidylcholines	141-160	hemoglobin subunit gamma 2	Homo sapiens	57-70
3085719-0	1986	Anion effects on the reaction of lecithin-cholesterol acyltransferase with discoidal complexes of phosphatidylcholines .	Phosphatidylcholines	98-118	lecithin-cholesterol acyltransferase	Homo sapiens	33-69
3756002-0	1986	The supply of both CDP-choline and diacylglycerol can regulate the rate of phosphatidylcholine synthesis in HeLa cells.	Phosphatidylcholines	75-94	cut like homeobox 1	Homo sapiens	19-22
3756002-1	1986	The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was measured in HeLa cells permeabilized with 0.125 mg digitonin/mL.	Phosphatidylcholines	50-69	cut like homeobox 1	Homo sapiens	33-36
3756002-2	1986	The rate of phosphatidylcholine formation was influenced by the concentration of CDP-choline in the medium.	Phosphatidylcholines	12-31	cut like homeobox 1	Homo sapiens	81-84
3756002-6	1986	The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was stimulated by the supply of diacylglycerol in both HeLa cells and isolated microsomes.	Phosphatidylcholines	50-69	cut like homeobox 1	Homo sapiens	33-36
3756002-11	1986	Furthermore, incubation of microsomes with [3H]diacylglycerol and [14C]CDP-choline showed that both of the substrates were incorporated into phosphatidylcholine at the same rate.	Phosphatidylcholines	141-160	cut like homeobox 1	Homo sapiens	71-74
3756002-13	1986	These results suggest that both in the permeabilized cells and in isolated membranes, the biosynthesis of phosphatidylcholine can be limited by both CDP-choline and diacylglycerol.	Phosphatidylcholines	106-125	cut like homeobox 1	Homo sapiens	149-152
3487640-5	1986	[3H]CsA bound only nonspecifically to phosphatidylcholine:cholesterol liposomes.	Phosphatidylcholines	38-57	heat shock protein 9	Mus musculus	4-7
3087773-2	1986	In addition, phospholipase A2 activity was measured directly with two different substrates, phosphatidylcholine and labelled E. coli.	Phosphatidylcholines	92-111	phospholipase A2 group IB	Rattus norvegicus	13-29
3700412-0	1986	Fluorescence quenching of cytochrome b5 in vesicles with an asymmetric transbilayer distribution of brominated phosphatidylcholine.	Phosphatidylcholines	111-130	cytochrome b5 type A	Homo sapiens	26-39
3759928-5	1986	The partially purified cytochrome P-450 efficiently catalyzed the omega-hydroxylation of various prostaglandins such as PGE1, PGE2, PGF2 alpha, PGD2, and PGA1 in a reconstituted system containing NADPH-cytochrome P-450 reductase, cytochrome b5, and phosphatidylcholine.	Phosphatidylcholines	249-268	cytochrome P-450	Oryctolagus cuniculus	23-39
3729948-1	1986	The effect of apolipoprotein C-II (apoC-II) and a synthetic fragment of apoC-II corresponding to residues 56-79 on the lipoprotein lipase (LpL) catalyzed hydrolysis of trioleoylglycerol in a monolayer of egg phosphatidylcholine and of dipalmitoylphosphatidylcholine vesicles was examined.	Phosphatidylcholines	208-227	lipoprotein lipase	Homo sapiens	119-137
3729948-1	1986	The effect of apolipoprotein C-II (apoC-II) and a synthetic fragment of apoC-II corresponding to residues 56-79 on the lipoprotein lipase (LpL) catalyzed hydrolysis of trioleoylglycerol in a monolayer of egg phosphatidylcholine and of dipalmitoylphosphatidylcholine vesicles was examined.	Phosphatidylcholines	208-227	lipoprotein lipase	Homo sapiens	139-142
3758663-1	1986	Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC).	Phosphatidylcholines	234-254	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	89-94
3758663-1	1986	Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC).	Phosphatidylcholines	256-258	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	89-94
3707951-3	1986	All of the PE-PC systems examined, which contained saturated or trans-unsaturated PC components, showed limited solid-phase miscibility, chiefly because the PC component can adopt more solid phases than the PE component.	Phosphatidylcholines	82-84	peptidase C	Homo sapiens	11-16
3707893-7	1986	There is a loss of about 20% of the intensity of the N(CH3)3 resonance from phosphatidylcholine and sphingomyelin molecules in the LDL spectrum; this is attributed to the presence of apolipoprotein B in the surface of LDL particles, which may immobilize some of the phospholipid polar groups.	Phosphatidylcholines	76-95	apolipoprotein B	Homo sapiens	183-199
3707601-1	1986	Purified mouse liver cytochrome P-450 reconstituted with purified NADPH-cytochrome P-450 reductase and phosphatidylcholine metabolized diethylphenylphosphine to diethylphenylphosphine oxide.	Phosphatidylcholines	103-122	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	21-37
3699017-2	1986	Human gastric lipase (HGL) activity on tributyrin emulsion was detected only in the presence of amphiphiles such as bile salts, proteins (serum albumin, beta-lactoglobulin or ovalbumin) or phosphatidylcholine.	Phosphatidylcholines	189-208	lipase F, gastric type	Homo sapiens	6-20
3699017-2	1986	Human gastric lipase (HGL) activity on tributyrin emulsion was detected only in the presence of amphiphiles such as bile salts, proteins (serum albumin, beta-lactoglobulin or ovalbumin) or phosphatidylcholine.	Phosphatidylcholines	189-208	lipase F, gastric type	Homo sapiens	22-25
3487067-2	1986	We have examined the effects of this growth factor on the biochemical development of explants of fetal rat lung, cultured in serum-free medium for 48 h. EGF enhanced the rate of choline incorporation into phosphatidylcholine and disaturated phosphatidylcholine in a dose dependent fashion.	Phosphatidylcholines	205-224	epidermal growth factor like 1	Rattus norvegicus	153-156
3964657-4	1986	Ca2+-induced fusion of phosphatidylserine vesicles served to test the method and was shown to have an exponential half-time of 7 s. Phase separation (between the phosphatidylserine head groups of bulk lipid and the phosphatidylcholine head groups of the probe) was monitored by DPHpPC under the same conditions used to follow lipid mixing due to fusion.	Phosphatidylcholines	215-234	carbonic anhydrase 2	Homo sapiens	0-3
3949783-3	1986	In a preliminary report we showed that the distribution of cytochrome b5 among a heterogeneous population of small sonicated phosphatidylcholine vesicles (212 to about 350 A in diameter) lies in favor of the smallest vesicles by a factor of at least 20 (Greenhut, S.F.	Phosphatidylcholines	125-144	cytochrome b5 type A	Homo sapiens	59-72
3957904-2	1986	In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine).	Phosphatidylcholines	10-29	cut-like homeobox 1	Rattus norvegicus	50-53
3957904-2	1986	In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine).	Phosphatidylcholines	10-29	cut-like homeobox 1	Rattus norvegicus	211-214
3718526-1	1986	Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators.	Phosphatidylcholines	9-28	3-hydroxybutyrate dehydrogenase 1	Bos taurus	121-155
3718526-1	1986	Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators.	Phosphatidylcholines	9-28	3-hydroxybutyrate dehydrogenase 1	Bos taurus	157-160
3718526-1	1986	Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators.	Phosphatidylcholines	30-32	3-hydroxybutyrate dehydrogenase 1	Bos taurus	121-155
3718526-1	1986	Although phosphatidylcholine (PC) has been shown to be the type of phospholipid required for activation of mitochondrial beta-hydroxybutyrate dehydrogenase (BDH), mixtures of phospholipids containing PC are more effective activators.	Phosphatidylcholines	30-32	3-hydroxybutyrate dehydrogenase 1	Bos taurus	157-160
3718526-4	1986	When different phospholipid mixtures containing PC were used to activate apo-BDH, and the reconstituted samples were subjected to cross-linking and SDS-gel electrophoresis, a direct relationship was found between the activating effect of the phospholipids used and BDH monomer concentration in the gels.	Phosphatidylcholines	48-50	3-hydroxybutyrate dehydrogenase 1	Bos taurus	77-80
3718526-4	1986	When different phospholipid mixtures containing PC were used to activate apo-BDH, and the reconstituted samples were subjected to cross-linking and SDS-gel electrophoresis, a direct relationship was found between the activating effect of the phospholipids used and BDH monomer concentration in the gels.	Phosphatidylcholines	48-50	3-hydroxybutyrate dehydrogenase 1	Bos taurus	265-268
3718526-7	1986	In addition to PC, which is required by BDH, other types of phospholipids play a role in activation of purified apo-BDH, possibly via enzyme disaggregation.	Phosphatidylcholines	15-17	3-hydroxybutyrate dehydrogenase 1	Bos taurus	40-43
3719068-0	1986	X-ray diffraction analysis of cytochrome b5 reconstituted in egg phosphatidylcholine vesicles.	Phosphatidylcholines	65-84	cytochrome b5 type A	Homo sapiens	30-43
3719068-1	1986	Cytochrome b5 was reconstituted asymmetrically into large unilamellar egg phosphatidylcholine vesicles.	Phosphatidylcholines	74-93	cytochrome b5 type A	Homo sapiens	0-13
3964663-2	1986	Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine.	Phosphatidylcholines	206-225	lipase C, hepatic type	Homo sapiens	25-55
3964663-2	1986	Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine.	Phosphatidylcholines	206-225	lipase C, hepatic type	Homo sapiens	57-62
3964663-2	1986	Interfacial catalysis of hepatic triacylglycerol lipase (H-TGL) and lipoprotein lipase (LpL) isolated from human post-heparin plasma was investigated with mixed monolayers of trioleoylglycerol (TO) and egg phosphatidylcholine.	Phosphatidylcholines	206-225	lipoprotein lipase	Homo sapiens	88-91
3964311-4	1986	Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates.	Phosphatidylcholines	64-83	phospholipase A2 group IB	Homo sapiens	9-13
3949762-1	1986	Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn).	Phosphatidylcholines	245-264	phospholipase A2 group IIA	Homo sapiens	49-53
3949762-1	1986	Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn).	Phosphatidylcholines	266-272	phospholipase A2 group IIA	Homo sapiens	49-53
3964311-4	1986	Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates.	Phosphatidylcholines	85-87	phospholipase A2 group IB	Homo sapiens	9-13
3947653-1	1986	When 600 X g supernatants of 10% (w/v) rat lung homogenates were incubated with CDP[Me-14C]choline both saturated and unsaturated species of phosphatidylcholine were formed from endogenous diacylglycerols.	Phosphatidylcholines	141-160	cut-like homeobox 1	Rattus norvegicus	80-83
3754566-5	1986	The content of phosphatidylcholine (PC) and dipalmitoylphosphatidylcholine (DPPC) after treatment with PRL was demonstrated to be significantly higher than the control.	Phosphatidylcholines	15-34	prolactin	Rattus norvegicus	103-106
3754566-5	1986	The content of phosphatidylcholine (PC) and dipalmitoylphosphatidylcholine (DPPC) after treatment with PRL was demonstrated to be significantly higher than the control.	Phosphatidylcholines	36-38	prolactin	Rattus norvegicus	103-106
3004591-5	1986	Treatment of the phosphatidylcholine fraction with phospholipase A2 released 64% of the 5-[3H]HETE with 26% remaining in the lysophosphatidylcholine fraction.	Phosphatidylcholines	17-36	phospholipase A2 group IB	Homo sapiens	51-67
3002473-0	1986	Effects of chlorpromazine and other calmodulin antagonists on phosphatidylcholine-induced vesiculation of platelet plasma membranes.	Phosphatidylcholines	62-81	calmodulin 1	Homo sapiens	36-46
3081034-0	1986	Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes.	Phosphatidylcholines	60-79	solute carrier family 38, member 5	Rattus norvegicus	38-42
3511973-6	1986	Insulin also stimulated the incorporation of choline and glucose into phosphatidylcholine and disaturated phosphatidylcholine.	Phosphatidylcholines	70-89	insulin	Oryctolagus cuniculus	0-7
3944128-1	1986	Cytochrome P-450 (P-450C21), purified from bovine adrenocortical microsomes, was incorporated into the single bilayer liposomes of egg yolk phosphatidylcholine by gel filtration, using a high pressure liquid chromatography system.	Phosphatidylcholines	140-159	steroid 21-hydroxylase	Bos taurus	18-26
3944128-3	1986	The apparent dissociation constant of the P-450C21-substrate complex increased with phosphatidylcholine concentration in the system, showing the substrate to be partitioned between the aqueous and lipid phases.	Phosphatidylcholines	84-103	steroid 21-hydroxylase	Bos taurus	42-50
3942760-5	1986	(2) The lecithin: cholesterol acyltransferase reactivity of HDL3, containing different amounts of phosphatidylcholine, as achieved by various degrees of phospholipase A2 treatment, was measured using a crude preparation of lecithin: cholesterol acyltransferase (the d 1.21-1.25 g/ml plasma fraction).	Phosphatidylcholines	98-117	lecithin-cholesterol acyltransferase	Homo sapiens	8-45
3942760-5	1986	(2) The lecithin: cholesterol acyltransferase reactivity of HDL3, containing different amounts of phosphatidylcholine, as achieved by various degrees of phospholipase A2 treatment, was measured using a crude preparation of lecithin: cholesterol acyltransferase (the d 1.21-1.25 g/ml plasma fraction).	Phosphatidylcholines	98-117	HDL3	Homo sapiens	60-64
3942763-1	1986	The effect of apolipoproteins C-II and C-III on the lipoprotein lipase-catalyzed hydrolysis of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and particles of trioleoylglycerol stabilized with a phosphatidylcholine monolayer was investigated.	Phosphatidylcholines	212-231	lipoprotein lipase	Homo sapiens	52-70
3002470-0	1986	Spin-label studies on phosphatidylcholine-cholesterol membranes: effects of alkyl chain length and unsaturation in the fluid phase.	Phosphatidylcholines	22-41	spindlin 1	Homo sapiens	0-4
3942763-1	1986	The effect of apolipoproteins C-II and C-III on the lipoprotein lipase-catalyzed hydrolysis of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and particles of trioleoylglycerol stabilized with a phosphatidylcholine monolayer was investigated.	Phosphatidylcholines	212-231	apolipoprotein C2	Homo sapiens	95-114
3009039-1	1986	Ca2+-translocating activities of phosphatidylinositol, diacylglycerol and phosphatidic acid were investigated in phosphatidylcholine liposomes.	Phosphatidylcholines	113-132	carbonic anhydrase 2	Homo sapiens	0-3
3009039-2	1986	Using a fluorescent indicator of Ca2+ concentration, quin-2, release of encapsulated Ca2+ from egg yolk phosphatidylcholine liposomes containing 2 mol% of one of these lipids was measured at 37 degrees C. The rate of Ca2+ translocation across the liposomal membrane mediated by phosphatidic acid was about 3-fold larger than those mediated by phosphatidylinositol and diacylglycerol.	Phosphatidylcholines	104-123	carbonic anhydrase 2	Homo sapiens	85-88
3009039-2	1986	Using a fluorescent indicator of Ca2+ concentration, quin-2, release of encapsulated Ca2+ from egg yolk phosphatidylcholine liposomes containing 2 mol% of one of these lipids was measured at 37 degrees C. The rate of Ca2+ translocation across the liposomal membrane mediated by phosphatidic acid was about 3-fold larger than those mediated by phosphatidylinositol and diacylglycerol.	Phosphatidylcholines	104-123	carbonic anhydrase 2	Homo sapiens	85-88
3942762-1	1986	The triacylglycerol hydrolyase and phospholipase A1 activities of bovine milk lipoprotein lipase toward long-chain fatty acyl ester substrates were investigated with monomolecular lipid films containing trioleoylglycerol and phosphatidylcholine.	Phosphatidylcholines	225-244	lipoprotein lipase	Bos taurus	78-96
3942762-2	1986	In a monolayer of egg phosphatidylcholine containing 3 mol% [14C]trioleoylglycerol, and in the presence of apolipoprotein C-II, a 79 amino acid activator protein for lipoprotein lipase, enzyme activity was maximal at a surface pressure of 21-22 mN X m-1 (37 mumol oleic acid released/h per mg enzyme); enzyme activity was enhanced 9-fold by apolipoprotein C-II.	Phosphatidylcholines	22-41	apolipoprotein C2	Bos taurus	107-126
3700364-1	1986	Selectivity factors (Vm/Km) for human and rat lecithin: cholesterol acyltransferases (LCAT) for the transfer of various acyl groups from the 2-position of phosphatidylcholine were determined.	Phosphatidylcholines	155-174	lecithin cholesterol acyltransferase	Rattus norvegicus	46-84
3700364-1	1986	Selectivity factors (Vm/Km) for human and rat lecithin: cholesterol acyltransferases (LCAT) for the transfer of various acyl groups from the 2-position of phosphatidylcholine were determined.	Phosphatidylcholines	155-174	lecithin cholesterol acyltransferase	Rattus norvegicus	86-90
3700364-2	1986	By multiplying these values by the proportions of acyl groups at the 2-position of phosphatidylcholine, one can predict the proportions of molecular species of cholesterol ester which will be synthesized by LCAT.	Phosphatidylcholines	83-102	lecithin-cholesterol acyltransferase	Homo sapiens	207-211
3080314-1	1986	Lecithin: cholesterol acyltransferase (LCAT, phosphatidylcholine: sterol O-acyltransferase, EC 2.3.1.43) was purified approximately 20 000-fold from pig plasma by ultracentrifugation, phenyl-Sepharose and hydroxyapatite chromatography.	Phosphatidylcholines	45-64	lecithin-cholesterol acyltransferase	Sus scrofa	0-37
3080314-1	1986	Lecithin: cholesterol acyltransferase (LCAT, phosphatidylcholine: sterol O-acyltransferase, EC 2.3.1.43) was purified approximately 20 000-fold from pig plasma by ultracentrifugation, phenyl-Sepharose and hydroxyapatite chromatography.	Phosphatidylcholines	45-64	lecithin-cholesterol acyltransferase	Sus scrofa	39-43
3080314-13	1986	In contrast, the LCAT activity was significantly reduced by liposomes with phosphatidylcholine/cholesterol molar ratios below 3:1.	Phosphatidylcholines	75-94	lecithin-cholesterol acyltransferase	Homo sapiens	17-21
2870863-1	1986	In isotonic saline-buffered conditions, phospholipase A2 from bee venom cleaves up to 65% of the phosphatidylcholine of the rabbit RBC membrane without causing significant hemolysis; however, the volume and the osmotic fragility of the treated RBC is modified.	Phosphatidylcholines	97-116	phospholipase A2	Oryctolagus cuniculus	40-56
3948674-0	1986	[The role of cytochrome P-450 in the activation of phosphatidyl choline hydrolysis by phospholipase A2].	Phosphatidylcholines	51-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	13-29
3948674-0	1986	[The role of cytochrome P-450 in the activation of phosphatidyl choline hydrolysis by phospholipase A2].	Phosphatidylcholines	51-71	phospholipase A2 group IB	Homo sapiens	86-102
4054131-6	1985	With egg yolk phosphatidylcholine as acyl donor, apo E was 15-19% as efficient as apolipoprotein A-I for activation of the acyltransferase.	Phosphatidylcholines	14-33	apolipoprotein E	Homo sapiens	49-54
3029548-1	1986	The ability of apocytochrome c and the heme containing respiratory chain component, cytochrome c, to induce fusion of phosphatidylcholine (PC) small unilamellar vesicles containing 0-50 mol % negatively charged lipids was examined.	Phosphatidylcholines	118-137	cytochrome c, somatic	Homo sapiens	18-30
3775794-0	1986	Hydrolysis of short-chain phosphatidylcholines by bee venom phospholipase A2.	Phosphatidylcholines	26-46	phospholipase A2 group IB	Homo sapiens	60-76
4091805-1	1985	The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor, was examined in brain homogenates from rats of various ages.	Phosphatidylcholines	119-138	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-60
4091805-1	1985	The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor, was examined in brain homogenates from rats of various ages.	Phosphatidylcholines	140-146	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-60
4087304-1	1985	Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method.	Phosphatidylcholines	13-32	methionine adenosyltransferase 1A	Rattus norvegicus	41-64
4087304-1	1985	Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method.	Phosphatidylcholines	13-32	methionine adenosyltransferase 1A	Rattus norvegicus	66-72
4087304-1	1985	Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method.	Phosphatidylcholines	34-36	methionine adenosyltransferase 1A	Rattus norvegicus	41-64
4087304-1	1985	Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method.	Phosphatidylcholines	34-36	methionine adenosyltransferase 1A	Rattus norvegicus	66-72
3932344-7	1985	The formation of complexes between vesicles and apo-A-I followed a two-step process; below or above the lipid phase transition temperature (Tc), apo-A-I bound to phosphatidylcholine vesicles but caused little leakage of contents.	Phosphatidylcholines	162-181	apolipoprotein A1	Homo sapiens	48-55
3932344-7	1985	The formation of complexes between vesicles and apo-A-I followed a two-step process; below or above the lipid phase transition temperature (Tc), apo-A-I bound to phosphatidylcholine vesicles but caused little leakage of contents.	Phosphatidylcholines	162-181	apolipoprotein A1	Homo sapiens	145-152
3944656-6	1986	Milk phosphatidylcholine and sphingomyelin concentrations remained relatively constant throughout lactation (100-200 nmol/ml).	Phosphatidylcholines	5-24	Weaning weight-maternal milk	Bos taurus	0-4
3944656-9	1986	Milk contained no phospholipase activity capable of forming free choline from phosphatidylcholine or sphingomyelin.	Phosphatidylcholines	78-97	Weaning weight-maternal milk	Bos taurus	0-4
2865977-0	1985	Role of stearoyl-CoA desaturase and 1-acylglycerophosphorylcholine acyltransferase in the regulation of the acyl composition of phosphatidylcholine in rat liver.	Phosphatidylcholines	128-147	stearoyl-CoA desaturase	Rattus norvegicus	8-31
2865977-1	1985	The role of stearoyl-CoA desaturase and 1-acylglycerophosphorylcholine (1-acylGPC) acyltransferase in regulating acyl composition of microsomal phosphatidylcholine was investigated in rat liver, using rats in five different kinds of physiological state: clofibric acid-fed rats, diabetic rats, insulin-treated diabetic rats, starved rats and starved-refed rats.	Phosphatidylcholines	144-163	stearoyl-CoA desaturase	Rattus norvegicus	12-35
2865977-6	1985	The physiological significance of stearoyl-CoA desaturase and 1-acylGPC acyltransferase was discussed in relation to the regulation of the acyl composition of phosphatidylcholine.	Phosphatidylcholines	159-178	stearoyl-CoA desaturase	Rattus norvegicus	34-57
2413893-1	1985	Myelin basic protein induces slow and limited fusion of phospholipid vesicles composed of a mixture of phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	103-122	myelin basic protein	Homo sapiens	0-20
4054131-7	1985	Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control).	Phosphatidylcholines	173-192	apolipoprotein E	Homo sapiens	0-5
4054131-7	1985	Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control).	Phosphatidylcholines	276-295	apolipoprotein E	Homo sapiens	0-5
3862730-4	1985	Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN).	Phosphatidylcholines	104-123	phospholipase A2 group IB	Homo sapiens	68-84
4056060-5	1985	Finally, an increase in cell recognition as determined by monocyte phagocytosis and adherence in vitro, as well as decreased phosphatidylcholine accessibility to bee venom phospholipase A2, was found in H2O2-treated erythrocytes compared with controls.	Phosphatidylcholines	125-144	phospholipase A2 group IB	Homo sapiens	172-188
3862730-4	1985	Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN).	Phosphatidylcholines	125-127	phospholipase A2 group IB	Homo sapiens	68-84
2412585-3	1985	In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments.	Phosphatidylcholines	45-64	myelin basic protein	Homo sapiens	70-90
3002436-5	1985	With the maltosides, changing the length of the alkyl tail affected the activity of cytochrome c oxidase in a manner quite similar to that reported with synthetic phosphatidylcholines and phosphatidylethanolamines [Vik, S. B., &amp; Capaldi, R. A.	Phosphatidylcholines	163-183	zinc finger protein 655	Homo sapiens	215-218
2995357-4	1985	Fusion between the virus envelopes and phosphatidylcholine/cholesterol liposomes was absolutely dependent upon the presence of intact and active hemagglutinin/neuraminidase and fusion viral envelope glycoproteins.	Phosphatidylcholines	39-58	neuraminidase 1	Homo sapiens	159-172
4052568-4	1985	P-31 CP spectra of all the phosphatidylcholines and phosphatidylethanolamine revealed a decrease in intensity in the vicinity of the isotropic chemical shift as long as the lipid was above the gel-to-liquid crystalline phase transition temperature.	Phosphatidylcholines	27-47	ATPase H+ transporting V1 subunit E1	Bos taurus	0-4
4041470-1	1985	Apolipoprotein A-IV, apolipoprotein E-2 and apolipoprotein E-3 were individually incorporated into defined phosphatidylcholine/cholesterol liposomes for study of lecithin:cholesterol acyltransferase activation.	Phosphatidylcholines	107-126	apolipoprotein A4	Homo sapiens	0-39
4041470-1	1985	Apolipoprotein A-IV, apolipoprotein E-2 and apolipoprotein E-3 were individually incorporated into defined phosphatidylcholine/cholesterol liposomes for study of lecithin:cholesterol acyltransferase activation.	Phosphatidylcholines	107-126	apolipoprotein E	Homo sapiens	44-62
3931645-7	1985	Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	68-87	angiotensinogen	Rattus norvegicus	0-14
3931645-7	1985	Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylcholines	89-91	angiotensinogen	Rattus norvegicus	0-14
3931645-9	1985	Thus we assume that angiotensin II may induce a shift in phospholipid synthesis from PC and PE to phosphoinositides.	Phosphatidylcholines	85-87	angiotensinogen	Rattus norvegicus	20-34
4084502-1	1985	Deuterium nuclear magnetic resonance (2H NMR) spectra from aqueous dispersions of phosphatidylcholines in which perdeuterated palmitic acid is esterified at the sn-1 position have several very useful features.	Phosphatidylcholines	82-102	solute carrier family 38 member 3	Homo sapiens	161-165
4044030-2	1985	Subsequently, the methylated phosphatidylcholine was degraded by activated phospholipase A2.	Phosphatidylcholines	29-48	phospholipase A2	Oryctolagus cuniculus	75-91
2413014-2	1985	Purified sodium channels incorporated into phosphatidylcholine (PC) vesicles mediate neurotoxin-activated 22Na+ influx but do not bind the alpha-scorpion toxin from Leiurus quinquestriatus (LqTx) with high affinity.	Phosphatidylcholines	43-62	procollagen C-endopeptidase enhancer	Rattus norvegicus	64-66
4041451-3	1985	In cardiolipin liposomes and in cardiolipin-phosphatidylcholine (1:1) liposomes, the drug inhibits the ability of Ca2+ to induce the hexagonal HII phase.	Phosphatidylcholines	44-63	carbonic anhydrase 2	Rattus norvegicus	114-117
3930615-6	1985	Therefore, TPA probably is not involved in the turnover of PI in these cells but is involved in the activation of PC hydrolyzing phospholipase A2 and PI hydrolyzing phospholipase C in these keratinocytes releasing arachidonic acid which then undergoes oxygenation reactions to provide biologically active eicosanoids.	Phosphatidylcholines	114-116	phospholipase A2, group IB, pancreas	Mus musculus	129-145
4019488-2	1985	The effect of cholesteryl oleate on the lipoprotein lipase-catalyzed hydrolysis of trioleoylglycerol was determined in monolayers of egg phosphatidylcholine at a constant surface pressure of 24 mN m-1.	Phosphatidylcholines	137-156	lipoprotein lipase	Bos taurus	40-58
3841007-1	1985	The effect of the altered polar head group of phosphatidylcholine (PC) on its transbilayer distributions in small unilamellar vesicles containing sphingomyelin (SM) was ascertained with phospholipase A2 as the external membrane probe.	Phosphatidylcholines	46-65	phospholipase A2 group IB	Homo sapiens	186-202
3841007-1	1985	The effect of the altered polar head group of phosphatidylcholine (PC) on its transbilayer distributions in small unilamellar vesicles containing sphingomyelin (SM) was ascertained with phospholipase A2 as the external membrane probe.	Phosphatidylcholines	67-69	phospholipase A2 group IB	Homo sapiens	186-202
4082107-4	1985	For platelet-derived membranes and for equimolar, charged-lipid/phosphatidylcholine (PC) vesicles, the critical concentrations increased in the following order: platelet-derived membranes approximately equal to phosphatidylserine (PS) approximately equal to phosphatidic acid (PA) less than monomethyl PA and monoethyl PA much less than phosphatidylinositol and phosphatidylglycerol.	Phosphatidylcholines	64-83	protocadherin 8	Homo sapiens	85-87
4085087-3	1985	The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity.	Phosphatidylcholines	123-142	lecithin-cholesterol acyltransferase	Homo sapiens	31-67
4085087-3	1985	The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity.	Phosphatidylcholines	123-142	lecithin-cholesterol acyltransferase	Homo sapiens	69-73
4085088-2	1985	Removal of the protective group by treatment with HCl in chloroform was followed by subsequent reaction with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form the fluorescent analogue of phosphatidylcholine, 1-oleoyl-2-(NBD)aminocaproyl-sn-glycero-3-phosphocholine, in good yield and with high isomeric purity.	Phosphatidylcholines	194-213	OXA1L mitochondrial inner membrane protein	Homo sapiens	133-138
2412224-4	1985	These proteins could be incorporated into phosphatidylcholine liposomes and mediated the specific binding of these liposomes to vitronectin but not to fibronectin.	Phosphatidylcholines	42-61	vitronectin	Homo sapiens	128-139
4064223-1	1985	The phosphatidylcholine transfer protein (PC-TP) from bovine liver has a binding site for phosphatidylcholine (PC).	Phosphatidylcholines	4-23	phosphatidylcholine transfer protein	Bos taurus	42-47
2990564-1	1985	The Ca2+ dependent incorporation of [14C]ethanolamine, L-[14C]serine and [14C]choline into phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine, respectively, were investigated in membrane preparations from rat heart.	Phosphatidylcholines	140-159	carbonic anhydrase 2	Rattus norvegicus	4-7
3931627-4	1985	On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids.	Phosphatidylcholines	116-135	transcription factor Maf	Cavia porcellus	19-22
3931627-4	1985	On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids.	Phosphatidylcholines	137-139	transcription factor Maf	Cavia porcellus	19-22
3927906-1	1985	A cell-free human polymorphonuclear leukocyte preparation containing both 15- and 5-lipoxygenase activities was found to oxygenate phosphatidylcholine at carbon-15 of the arachidonic acid moiety.	Phosphatidylcholines	131-150	arachidonate 15-lipoxygenase	Homo sapiens	74-96
4063348-4	1985	For both types of sn-2 acyl chain, assuming a single-exponential correlation time and that the motion is within the rapid regime, the phosphatidylcholine lipid systems are less mobile than their phosphatidylethanolamine analogues.	Phosphatidylcholines	134-153	solute carrier family 38 member 5	Homo sapiens	18-22
3904950-5	1985	Phosphatidylcholine is made in liver by two alternate pathways, by the CDP-choline pathway and by the methylation of phosphatidylethanolamine.	Phosphatidylcholines	0-19	cut-like homeobox 1	Rattus norvegicus	71-74
3904950-6	1985	Regulation of phosphatidylcholine biosynthesis by the CDP-choline pathway in rat liver is well established.	Phosphatidylcholines	14-33	cut-like homeobox 1	Rattus norvegicus	54-57
3904950-7	1985	In most instances, the rate of phosphatidylcholine synthesis is governed by the activity of CTP:phosphocholine cytidylyltransferase, which is present in the cytosol and also associated with microsomes.	Phosphatidylcholines	31-50	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	92-131
4052389-1	1985	The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy.	Phosphatidylcholines	125-144	lipoprotein lipase	Homo sapiens	19-37
3926761-1	1985	In a continued investigation of lecithin cholesterol acyltransferase reaction with micellar discoidal complexes of phosphatidylcholine, cholesterol, and various water soluble apolipoproteins, we prepared complexes containing human apo-E by the cholate dialysis method.	Phosphatidylcholines	115-134	apolipoprotein E	Homo sapiens	231-236
4016107-1	1985	Synthetic phosphatidylcholines inhibited thrombin-induced aggregation of rabbit platelets.	Phosphatidylcholines	10-30	prothrombin	Oryctolagus cuniculus	41-49
4038271-0	1985	Degradation of mono-oleoylglycerol, trioleoylglycerol and phosphatidylcholine in emulsions and lipoproteins by rat hepatic acylglycerol lipase.	Phosphatidylcholines	58-77	lipase G, endothelial type	Rattus norvegicus	136-142
4052389-1	1985	The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy.	Phosphatidylcholines	125-144	lipoprotein lipase	Homo sapiens	39-42
4016107-6	1985	The amounts of phosphatidylcholines required for 50% inhibition of platelet aggregation correspond very well to those required for 15% exfoliation of acetylcholinesterase activity, suggesting that there is a close relationship between platelet aggregation and vesiculation of the platelet plasma membrane.	Phosphatidylcholines	15-35	ACE-1	Oryctolagus cuniculus	150-170
4052389-1	1985	The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy.	Phosphatidylcholines	125-144	apolipoprotein C2	Homo sapiens	71-90
4052389-1	1985	The interaction of lipoprotein lipase (LpL) and its activator protein, apolipoprotein C-II (apoC-II), with a nonhydrolyzable phosphatidylcholine, 1,2-ditetradecyl-rac-glycero-3-phosphocholine (C14-ether-PC), was studied by fluorescence spectroscopy.	Phosphatidylcholines	125-144	apolipoprotein C2	Homo sapiens	92-99
4052389-6	1985	The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces.	Phosphatidylcholines	230-249	apolipoprotein C2	Homo sapiens	69-76
4052389-6	1985	The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces.	Phosphatidylcholines	230-249	lipoprotein lipase	Homo sapiens	190-193
4005286-15	1985	This choline was derived, in part, from the degradation of phosphatidylcholine, and we suggest that phospholipase A activity was the primary initiator of choline release from this phospholipid.	Phosphatidylcholines	59-78	phospholipase A and acyltransferase 1	Rattus norvegicus	100-115
4052389-6	1985	The dissociation constant (Kd) of the complex is 4.3 X 10(-8) M. For apoC-II, the stoichiometry of the complex is 18 PC per apoprotein, and the Kd is 3.0 X 10(-6) M. These data suggest that LpL binds more strongly than apoC-II to phosphatidylcholine interfaces.	Phosphatidylcholines	230-249	apolipoprotein C2	Homo sapiens	219-226
4052390-6	1985	Cobra venom phospholipase A2 hydrolyzes monomeric short-chain PE"s at about the same rate as short-chain PC"s but hydrolyzes long-chain PC"s much more rapidly than long-chain PE"s.	Phosphatidylcholines	105-107	phospholipase A2 group IB	Homo sapiens	12-28
4052390-6	1985	Cobra venom phospholipase A2 hydrolyzes monomeric short-chain PE"s at about the same rate as short-chain PC"s but hydrolyzes long-chain PC"s much more rapidly than long-chain PE"s.	Phosphatidylcholines	136-138	phospholipase A2 group IB	Homo sapiens	12-28
2990533-4	1985	Spin-labeling and radiolabeling data show that the incorporation of (4 +/- 1) X 10(6) molecules of exogenous phosphatidylcholine per cell converts discocytes to stage 3 echinocytes with about 35 conical spicules.	Phosphatidylcholines	109-128	spindlin 1	Homo sapiens	0-4
3998733-4	1985	The incubation of microsomes with CDP-[14C]choline or [14C]choline showed that most of the newly synthesized phosphatidylcholine molecules were localized in the external leaflet.	Phosphatidylcholines	109-128	cut like homeobox 1	Homo sapiens	34-37
2988634-1	1985	Apolipoprotein A-I/phosphatidylcholine/cholesterol complexes formed in a 2-chloroethanol-water mixture.	Phosphatidylcholines	19-38	apolipoprotein A1	Homo sapiens	0-18
2988634-2	1985	Apolipoprotein A-I can spontaneously associate with phosphatidylcholine and cholesterol in 2-chloroethanol-water mixture.	Phosphatidylcholines	52-71	apolipoprotein A1	Homo sapiens	0-18
2988634-4	1985	The apolipoprotein A-I/phosphatidylcholine/cholesterol complexes were isolated by gel chromatography.	Phosphatidylcholines	23-42	apolipoprotein A1	Homo sapiens	4-22
3929832-0	1985	Effects of amino group modification in discoidal apolipoprotein A-I-egg phosphatidylcholine-cholesterol complexes on their reactions with lecithin:cholesterol acyltransferase.	Phosphatidylcholines	72-91	apolipoprotein A1	Homo sapiens	49-67
3929832-0	1985	Effects of amino group modification in discoidal apolipoprotein A-I-egg phosphatidylcholine-cholesterol complexes on their reactions with lecithin:cholesterol acyltransferase.	Phosphatidylcholines	72-91	lecithin-cholesterol acyltransferase	Homo sapiens	138-174
3929832-1	1985	Discoidal complexes of human apolipoprotein A-I-egg phosphatidylcholine-cholesterol were prepared by the sodium cholate dialysis procedure and were reacted to varying extents with the amino group reagents citraconic anhydride, diketene, and formaldehyde in the presence of sodium borohydride.	Phosphatidylcholines	52-71	apolipoprotein A1	Homo sapiens	29-47
2859892-2	1985	The pig small intestinal dipeptidyl peptidase IV was asymmetrically integrated into egg phosphatidylcholine and microvillar lipid vesicles prepared by a beta-octylglucoside dialysis method.	Phosphatidylcholines	88-107	dipeptidyl peptidase 4	Sus scrofa	25-48
4041563-0	1985	Hydrolysis of phosphatidylcholine liposomes by lysosomal phospholipase A is maximal at the phase transition temperature of the lipid substrate.	Phosphatidylcholines	14-33	phospholipase A and acyltransferase 1	Rattus norvegicus	57-72
4016077-1	1985	Cytochrome b5, a protein isolated from the endoplasmic reticulum by detergent extraction, interacts spontaneously with small unilamellar phosphatidylcholine vesicles.	Phosphatidylcholines	137-156	cytochrome b5 type A	Homo sapiens	0-13
4027218-4	1985	By incorporation of rhodopsin into a series of phosphatidylcholines of defined composition, we have determined the properties of the lipid environment that are responsible for the altered spectral behavior.	Phosphatidylcholines	47-67	rhodopsin	Homo sapiens	20-29
3906543-1	1985	Cortisol, in combination with prolactin and/or insulin, increases the rate of lamellar body phosphatidylcholine synthesis and markedly increases the secretion of lamellar bodies into the ductular lumens of human fetal lung explants maintained in serum-free medium.	Phosphatidylcholines	92-111	insulin	Homo sapiens	47-54
3925588-4	1985	For the activation of 0.25 microM prothrombin by factor Xa in the presence of 50 microM phospholipid (phosphatidylserine/phosphatidylcholine, 25/75; mol/mol) and 5 mM CaCl2 50% inhibition was obtained at 0.28 microM fragment 1 or fragment 1.2.	Phosphatidylcholines	121-140	coagulation factor II, thrombin	Bos taurus	34-45
4024704-2	1985	Phosphatidylcholine with arachidonoyl at position 2 was cleaved preferentially by an alkaline phospholipase A2 (pH-optimum 9.0) leading to selective liberation of arachidonic acid.	Phosphatidylcholines	0-19	phospholipase A2, group IB, pancreas	Mus musculus	94-110
3995060-4	1985	As well, concentrations of plasma membrane phosphatidylcholine and phosphatidylethanolamine in thrombin-stimulated platelets decreased by 20 and 9%, respectively, when compared with their control values.	Phosphatidylcholines	43-62	coagulation factor II, thrombin	Homo sapiens	95-103
4016572-1	1985	Addition of cardiolipin or diacylglycerol to dispersions of phosphatidylcholine greatly increased hydrolysis by snake venom or pancreatic phospholipase A2, as well as by a microbial phospholipase.	Phosphatidylcholines	60-79	phospholipase A2 group IB	Homo sapiens	138-154
3885949-4	1985	The action of insulin also depends on the phosphatidylcholine: phosphatidic acid molar ratio, and buffer and vesicles concentration.	Phosphatidylcholines	42-61	insulin	Bos taurus	14-21
3986373-4	1985	It has been shown in model experiments with incorporation into the tumor cell membrane of brain ganglioside GD3 combined with thymic LacCer or with egg phosphatidylcholine that the increase in the sensitivity of the tumor cell membrane to spleen effectors is linked with a change in the properties of the lipid membrane matrix under the effect of unsaturated fatty acids (e.g. in experiments with phosphatidylcholine).	Phosphatidylcholines	397-416	GRDX	Homo sapiens	108-111
4016574-11	1985	Hydrolysis of phosphatidylcholine by phospholipase A2 leads to an enzymatic stimulation.	Phosphatidylcholines	14-33	phospholipase A2	Ovis aries	37-53
3972013-4	1985	These data suggest that the process of receptor-mediated endocytosis of transferrin can proceed normally in the absence of de novo phosphatidylcholine synthesis.	Phosphatidylcholines	131-150	transferrin	Homo sapiens	72-83
3855929-7	1985	NK effector cells treated with phosphatidylcholine complexed with polyvinylpyrrolidone (PVP) and bovine serum albumin (BSA) showed increased membrane fluidity.	Phosphatidylcholines	31-50	albumin	Homo sapiens	104-117
3919022-4	1985	Inhibition of platelet aggregation by CRP is accompanied by an inhibition of arachidonic acid release from both phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	112-131	C-reactive protein	Homo sapiens	38-41
3921018-5	1985	Hydrolysis of PC by phospholipase A2 is likely to be the major route of arachidonic acid liberation in either IgE-mediated or non-IgE activation in mast cells.	Phosphatidylcholines	14-16	phospholipase A2 group IB	Rattus norvegicus	20-36
2982418-4	1985	Addition of phospholipase C resulted in increased synthesis of phosphatidylcholine from both labeled precursors; no significant changes were found in synthesis of most of the other 3H-labeled lipids.	Phosphatidylcholines	63-82	LOC100009319	Oryctolagus cuniculus	12-27
3919008-0	1985	Kinetics of lecithin-cholesterol acyltransferase reaction with discoidal complexes of apolipoprotein A-I.phosphatidylcholine.ether phospholipid.cholesterol.	Phosphatidylcholines	105-124	lecithin-cholesterol acyltransferase	Homo sapiens	12-48
3919008-0	1985	Kinetics of lecithin-cholesterol acyltransferase reaction with discoidal complexes of apolipoprotein A-I.phosphatidylcholine.ether phospholipid.cholesterol.	Phosphatidylcholines	105-124	apolipoprotein A1	Homo sapiens	86-104
3838686-7	1985	From these results we propose a long-range attractive interaction between bound Ca2+ and the polar head groups of distant phosphatidylcholine molecules.	Phosphatidylcholines	122-141	carbonic anhydrase 2	Homo sapiens	80-83
2982398-7	1985	Among phospholipids with the same acyl moiety but different head groups, phosphatidylethanolamine was found to be more effective than phosphatidylcholine in protecting cytochrome c oxidase from thermodenaturation.	Phosphatidylcholines	134-153	cytochrome c, somatic	Homo sapiens	168-180
3918999-7	1985	Complexes of phosphatidylcholines substituted with two saturated fatty acids served as substrate for lecithin:cholesterol acyltransferase even in the absence of any activator protein.	Phosphatidylcholines	13-33	lecithin-cholesterol acyltransferase	Homo sapiens	101-137
4096905-1	1985	Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows.	Phosphatidylcholines	118-137	cytochrome b5 type A	Homo sapiens	0-13
4096905-1	1985	Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows.	Phosphatidylcholines	139-141	cytochrome b5 type A	Homo sapiens	0-13
3838249-3	1985	As part of the characterization of this preparation, the surface orientation of the carbohydrates of rhodopsin, assembled from purified bovine rhodopsin and egg phosphatidylcholine was examined, and is the topic of this report.	Phosphatidylcholines	161-180	rhodopsin	Bos taurus	101-110
3973457-1	1985	In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol.	Phosphatidylcholines	19-38	lecithin cholesterol acyltransferase	Rattus norvegicus	72-108
3987344-5	1985	The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine.	Phosphatidylcholines	283-302	phospholipase A2 group IB	Rattus norvegicus	16-32
3987344-5	1985	The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine.	Phosphatidylcholines	283-302	phospholipase A2 group IB	Rattus norvegicus	34-38
3155927-9	1985	Mixtures of phosphatidylserine and phosphatidylcholine produced intermediate ATPase activities, with the maximal value dependent on the phosphatidylserine concentration.	Phosphatidylcholines	35-54	dynein axonemal heavy chain 8	Homo sapiens	77-83
3973457-1	1985	In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol.	Phosphatidylcholines	19-38	lecithin cholesterol acyltransferase	Rattus norvegicus	110-114
3973457-1	1985	In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol.	Phosphatidylcholines	41-43	lecithin cholesterol acyltransferase	Rattus norvegicus	72-108
3973457-1	1985	In the plasma, lysophosphatidylcholine (LPC) is formed by the action of lecithin-cholesterol acyltransferase (LCAT) when a fatty acid is removed from plasma phosphatidylcholine (PC) and transferred to cholesterol.	Phosphatidylcholines	41-43	lecithin cholesterol acyltransferase	Rattus norvegicus	110-114
3992006-7	1985	Although LCAT activator (apoprotein A-I) was not markedly altered by dietary ethanol and the concentration of LCAT substrates (HDL free cholesterol and phosphatidyl choline) was significantly elevated in the High Ethanol group, subtle modifications in substrate-product composition may account for the observed reduction in cholesterol esterification.	Phosphatidylcholines	152-172	lecithin-cholesterol acyltransferase	Homo sapiens	110-114
3917684-7	1985	We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol.	Phosphatidylcholines	55-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
3881128-0	1985	Rhodopsin-egg phosphatidylcholine reconstitution by an octyl glucoside dilution procedure.	Phosphatidylcholines	14-33	rhodopsin	Bos taurus	0-9
3881128-1	1985	The transmembrane protein bovine rhodopsin was reconstituted with egg phosphatidylcholine (PC) by using a modified detergent dilution technique employing the nonionic detergent octyl-beta-D-glucoside (octyl glucoside).	Phosphatidylcholines	70-89	rhodopsin	Bos taurus	33-42
2981549-2	1985	We have characterized the quenching of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine by Co2+ in egg phosphatidylcholine (PC) lipid bilayer vesicles.	Phosphatidylcholines	116-135	complement C2	Homo sapiens	104-107
3917684-7	1985	We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol.	Phosphatidylcholines	134-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
4092816-1	1985	The hydrolysis of acyl esters in phosphatidylcholine by phospholipase A2 (PLA2) for human placental blood vessel was investigated.	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	56-72
2578294-1	1985	Two lipid transfer proteins, designated lipid transfer protein-I (Mr 69 000) and lipid transfer protein-II (Mr 55 000), each of which facilitates the transfer of radiolabelled cholesteryl ester, triacylglycerol and phosphatidylcholine between plasma lipoproteins, were purified from human plasma.	Phosphatidylcholines	215-234	cholesteryl ester transfer protein	Homo sapiens	40-64
2578294-1	1985	Two lipid transfer proteins, designated lipid transfer protein-I (Mr 69 000) and lipid transfer protein-II (Mr 55 000), each of which facilitates the transfer of radiolabelled cholesteryl ester, triacylglycerol and phosphatidylcholine between plasma lipoproteins, were purified from human plasma.	Phosphatidylcholines	215-234	phospholipid transfer protein	Homo sapiens	66-106
2578294-10	1985	Most plasma phosphatidylcholine transfer activity is mediated by a protein (or proteins) other than lipid transfer protein-I and lipid transfer protein-II.	Phosphatidylcholines	12-31	phospholipid transfer protein	Homo sapiens	129-154
2578294-11	1985	In lipoprotein-free plasma all cholesteryl ester and triacylglycerol transfer activity, and some phosphatidylcholine transfer activity, is mediated by lipid transfer protein-I (or lipid transfer protein-I and an antigenically similar protein, lipid transfer protein-II.	Phosphatidylcholines	97-116	cholesteryl ester transfer protein	Homo sapiens	151-175
4084264-1	1985	Cleavage of mitochondrial phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL) by phospholipase A2 but not selective degradation of PE and PC by phospholipase C dissociates creatine kinase from rat heart mitochondria.	Phosphatidylcholines	57-76	phospholipase A2 group IB	Rattus norvegicus	106-122
4084264-1	1985	Cleavage of mitochondrial phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL) by phospholipase A2 but not selective degradation of PE and PC by phospholipase C dissociates creatine kinase from rat heart mitochondria.	Phosphatidylcholines	78-80	phospholipase A2 group IB	Rattus norvegicus	106-122
3926598-4	1985	When phosphatidylcholine micelles were incubated with the enzyme in the presence of gabexate mesilate, the mode of inhibition of the enzyme action by the drug appeared to be noncompetitive and Ki of gabexate mesilate for phospholipase A2 was 0.77 mM.	Phosphatidylcholines	5-24	phospholipase A2 group IB	Homo sapiens	221-237
4092816-1	1985	The hydrolysis of acyl esters in phosphatidylcholine by phospholipase A2 (PLA2) for human placental blood vessel was investigated.	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	74-78
4092816-3	1985	In contrast to rat tissues, the human placental blood vessel PLA2 showed a selective preference for arachidonate over linoleate acyl group at the sn-2 position of phosphatidylcholine.	Phosphatidylcholines	163-182	phospholipase A2 group IB	Homo sapiens	61-65
4001746-1	1985	Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2.	Phosphatidylcholines	222-241	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-35
3997795-3	1985	At the same time it was metabolically converted into phosphatidylcholine (PC) and free fatty acid (FFA) plus glycerophosphorylcholine by the actions of acyltransferase and lysophospholipase, respectively.	Phosphatidylcholines	53-72	phospholipase B1	Homo sapiens	172-189
4001746-1	1985	Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2.	Phosphatidylcholines	222-241	phosphatidylethanolamine N-methyltransferase	Homo sapiens	37-41
3839593-3	1985	Cytidine diphosphocholine (CDP-choline) is an essential intermediary in the biosynthesis of PC.	Phosphatidylcholines	92-94	cut like homeobox 1	Homo sapiens	27-30
4001746-1	1985	Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2.	Phosphatidylcholines	222-241	phospholipase A2 group IB	Homo sapiens	256-272
6517928-4	1984	31P-NMR of phosphatidylcholine indicates that diacylglycerol causes an isotropic component to develop in the spectrum of the bilayers which correlates approximately with the enhancement of phospholipase A2 attack.	Phosphatidylcholines	11-30	phospholipase A2 group IB	Homo sapiens	189-205
6517595-5	1984	Normal-phase HPLC analysis confirmed that both PC and PE in the liver phospholipids were peroxidized after CCl4 treatment.	Phosphatidylcholines	47-49	C-C motif chemokine ligand 4	Rattus norvegicus	107-111
6594703-5	1984	That the lipase was functioning in the cultured brain cells was indicated by uptake and incorporation of radioactivity from tri[( 1-14C]oleoyl)glycerol into cellular triacylglycerols, and into more polar lipids, such as phosphatidylcholine.	Phosphatidylcholines	220-239	lipase G, endothelial type	Rattus norvegicus	9-15
6095861-9	1984	Cleavage of phosphatidylcholine to lyso-phosphatidylcholine occurred in the presence of either adrenergic agonists or histamine, indicating an involvement of phospholipase A2.	Phosphatidylcholines	12-31	phospholipase A2 group IB	Rattus norvegicus	158-174
6091780-5	1984	Thrombin caused loss of [14C]arachidonate-labelled phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol.	Phosphatidylcholines	51-70	coagulation factor II, thrombin	Sus scrofa	0-8
6508805-2	1984	When liposomes containing phosphatidylcholine were incubated with prothrombin and INA, the amount of incorporated label was greater in the absence of added calcium.	Phosphatidylcholines	26-45	coagulation factor II, thrombin	Homo sapiens	66-77
6523448-5	1984	These results show that thrombin-induced liberation of [3H]-arachidonic acid occurs entirely by a TFP-sensitive mechanism, and suggest that the major portion of the arachidonate is liberated from phosphatidylcholine with a possible contribution from phosphatidylinositol.	Phosphatidylcholines	196-215	coagulation factor II, thrombin	Homo sapiens	24-32
6094742-8	1984	The effect of low pH on sodium fluoride-stimulated and D-Ala enk-inhibited adenylate cyclase could be reversed by addition of either cis-vaccenic acid or phosphatidylcholine to treated membranes, but the effect on GTP regulation of binding was not reversed by lipid incorporation.	Phosphatidylcholines	154-173	proenkephalin	Rattus norvegicus	61-64
6436245-3	1984	Separation of platelet phospholipids and subsequent resolution into individual molecular species by high-performance liquid chromatography revealed that the newly formed alkylacyl-GPC was exclusively alkylarachidonoyl-GPC and that the arachidonoyl group for acylation of alkyllyso-GPC was provided by phosphatidylcholine.	Phosphatidylcholines	301-320	glycophorin C (Gerbich blood group)	Homo sapiens	180-183
6085169-0	1984	Substance P: binding to unilamellar and multilamellar liposomes made from mixtures of phosphatidylcholine and phosphatidic acid.	Phosphatidylcholines	86-105	tachykinin precursor 1	Homo sapiens	0-11
6392853-8	1984	In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	235-254	Ino4p	Saccharomyces cerevisiae S288C	107-111
6392853-8	1984	In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine.	Phosphatidylcholines	235-254	Ino2p	Saccharomyces cerevisiae S288C	116-120
6497946-11	1984	The major phospholipids in plasma are identical in both groups and there is an identical change under the PUFA diet, sphingomyelin is increased and phosphatidylcholine is decreased, which may be related to an increase of the HDL2/HDL3 ratio.	Phosphatidylcholines	148-167	junctophilin 3	Homo sapiens	225-229
6441309-7	1984	These results suggest that endogenous phospholipase A2 may break membrane phosphatidyl choline into lysophosphatidyl choline and fatty acid, when the acrosome reaction occurs.	Phosphatidylcholines	74-94	phospholipase A2 group IB	Homo sapiens	38-54
6437832-7	1984	Phosphatidylethanolamine and phosphatidylcholine were the most significant donors of AA during thrombin stimulation.	Phosphatidylcholines	29-48	coagulation factor II, thrombin	Homo sapiens	95-103
6391991-5	1984	The phosphatidyl choline and disaturated phosphatidyl choline were also higher in the fetuses injected with insulin+hydrocortisone than in fetuses injected with insulin or hydrocortisone alone.	Phosphatidylcholines	4-24	insulin	Oryctolagus cuniculus	108-115
6237161-7	1984	The PC-binding proteins possessed a typical phospholipase A2 activity, which was maximal at pH 9.5, depended on Ca++, and was specific for cleavage of fatty acid from the sn-2 position of phosphatidylcholine.	Phosphatidylcholines	188-207	phospholipase A2, group IB, pancreas	Mus musculus	44-60
6391991-5	1984	The phosphatidyl choline and disaturated phosphatidyl choline were also higher in the fetuses injected with insulin+hydrocortisone than in fetuses injected with insulin or hydrocortisone alone.	Phosphatidylcholines	4-24	insulin	Oryctolagus cuniculus	161-168
6391991-6	1984	These results suggest that insulin increases the phosphatidyl choline and disaturated phosphatidyl choline content in lung tissue in fetal rabbits in vivo, and that in the presence of hydrocortisone, insulin appears to have an additive effect.	Phosphatidylcholines	49-69	insulin	Oryctolagus cuniculus	27-34
6391991-6	1984	These results suggest that insulin increases the phosphatidyl choline and disaturated phosphatidyl choline content in lung tissue in fetal rabbits in vivo, and that in the presence of hydrocortisone, insulin appears to have an additive effect.	Phosphatidylcholines	86-106	insulin	Oryctolagus cuniculus	27-34
6510702-11	1984	It has been shown by freeze-fracture electron microscopy that the addition of Ca+2, Mg+2, Mn+2 or Cd+2 to suspensions of egg phosphatidylcholine and cardiolipin (1:1 or 3:1) leads to the formation of numerous intramembrane particles (imp"s) and crater-like (stalk) structures.	Phosphatidylcholines	125-144	carbonic anhydrase 2	Homo sapiens	78-82
6477954-5	1984	Egg phosphatidylcholine complexes of both human apolipoprotein A-I and apolipoprotein C"s competed for the HDL-binding sites, but phosphatidylcholine vesicles alone did not.	Phosphatidylcholines	4-23	apolipoprotein A1	Homo sapiens	48-66
6089898-11	1984	Therefore, while in the type II pneumocyte significant amounts of phosphatidylcholine (particularly the disaturated species) and phosphatidylethanolamine may be synthesized de novo, enzymes responsible for remodeling (phospholipase A2 and acyltransferases) may play an important role in establishing the final molecular species composition of both phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	348-367	phospholipase A2 group IB	Rattus norvegicus	218-234
6491538-2	1984	The microbial enzyme (GCAT) catalyzed acyl transfer using phosphatidylcholine and cholesterol in all of the lipoprotein fractions, presumably because it has no apolipoprotein cofactor.	Phosphatidylcholines	58-77	glycine C-acetyltransferase	Homo sapiens	22-26
6094205-10	1984	After cell prelabelling for 2 h in the presence of TSH, PAF-acether added for 15 min completely counteracted the hormone effects on PI and phosphatidylcholine (PC) but increased the phosphatidic acid (PA) labelling.	Phosphatidylcholines	139-158	PCNA clamp associated factor	Homo sapiens	56-59
6094205-10	1984	After cell prelabelling for 2 h in the presence of TSH, PAF-acether added for 15 min completely counteracted the hormone effects on PI and phosphatidylcholine (PC) but increased the phosphatidic acid (PA) labelling.	Phosphatidylcholines	160-162	PCNA clamp associated factor	Homo sapiens	56-59
6501257-7	1984	These reactions were absolutely dependent on cytochrome P-450p-2 and NADPH-cytochrome P-450 reductase, and stimulated by addition of phosphatidylcholine and cytochrome b5.	Phosphatidylcholines	133-152	cytochrome P450 4A5	Oryctolagus cuniculus	45-64
6501257-7	1984	These reactions were absolutely dependent on cytochrome P-450p-2 and NADPH-cytochrome P-450 reductase, and stimulated by addition of phosphatidylcholine and cytochrome b5.	Phosphatidylcholines	133-152	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	69-101
6548158-3	1984	Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence.	Phosphatidylcholines	102-121	LOC104974671	Bos taurus	19-35
6548158-3	1984	Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence.	Phosphatidylcholines	102-121	lipoprotein lipase	Bos taurus	52-70
6438077-1	1984	Interaction of human apolipoprotein A-II (apoA-II) with egg yolk phosphatidylcholine unilamellar vesicles (diameter, 20-26 nm) was studied.	Phosphatidylcholines	65-84	apolipoprotein A2	Homo sapiens	21-40
6438077-1	1984	Interaction of human apolipoprotein A-II (apoA-II) with egg yolk phosphatidylcholine unilamellar vesicles (diameter, 20-26 nm) was studied.	Phosphatidylcholines	65-84	apolipoprotein A2	Homo sapiens	42-49
6438077-10	1984	Thus the parameters represent the equilibrium binding of apoA-II to the surface of phosphatidylcholine unilamellar vesicles.	Phosphatidylcholines	83-102	apolipoprotein A2	Homo sapiens	57-64
6487589-3	1984	A symmetric and sharp wide-angle reflection at 4.11 A indicates that the hydrocarbon chains in hydrated C(18):C(10)PC bilayers are more tightly packed than in usual gel-state phosphatidylcholine bilayers and that there is no hydrocarbon chain tilt.	Phosphatidylcholines	175-194	Bardet-Biedl syndrome 9	Homo sapiens	104-109
6743672-4	1984	Saturated phosphatidic acid, diacylglycerol and phosphatidylglycerol were nearly equally labeled in the sn-1 and sn-2 positions, whereas saturated phosphatidylcholine was preferentially labeled in the sn-2 position.	Phosphatidylcholines	147-166	solute carrier family 38, member 5	Rattus norvegicus	201-205
6468604-2	1984	Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine.	Phosphatidylcholines	96-115	phospholipase A2 group IB	Homo sapiens	48-64
6430345-10	1984	These reaction rates correlate well with the apolipoprotein A-I fluorescence properties and indicate that the apolipoprotein structure, reflected at the interface with phosphatidylcholine, may be the most important factor in determining complex reactivity with lecithin:cholesterol acyltransferase.	Phosphatidylcholines	168-187	apolipoprotein A1	Homo sapiens	45-63
6430345-10	1984	These reaction rates correlate well with the apolipoprotein A-I fluorescence properties and indicate that the apolipoprotein structure, reflected at the interface with phosphatidylcholine, may be the most important factor in determining complex reactivity with lecithin:cholesterol acyltransferase.	Phosphatidylcholines	168-187	lecithin-cholesterol acyltransferase	Homo sapiens	261-297
6466698-0	1984	Lipoprotein lipase mediated uptake of non-degradable ether analogues of phosphatidylcholine and cholesteryl ester by cultured cells.	Phosphatidylcholines	72-91	lipoprotein lipase	Homo sapiens	0-18
6746652-0	1984	Relative degradation of different molecular species of phosphatidylcholine in thrombin-stimulated human platelets.	Phosphatidylcholines	55-74	coagulation factor II, thrombin	Homo sapiens	78-86
6746652-2	1984	This was of interest since previous work using radioactive fatty acids had led to the conclusion that the 1-acyl-2-arachidonoyl species of phosphatidylcholine is exclusively hydrolyzed in thrombin-stimulated platelets.	Phosphatidylcholines	139-158	coagulation factor II, thrombin	Homo sapiens	188-196
6746652-3	1984	Within 90 s, the thrombin-dependent release of [14C]arachidonic acid from phosphatidylcholine amounted to 25% but only 3 and 6% for oleic and linoleic acids, respectively, in general agreement with previous work.	Phosphatidylcholines	74-93	coagulation factor II, thrombin	Homo sapiens	17-25
6746652-4	1984	However, for [3H]glycerol-labeled phosphatidylcholine, all molecular species (saturates, monoenes, dienes, trienes, tetraenes, and greater than tetraenes) were subject to significant hydrolysis in the presence of thrombin within 90 s, ranging from 12-24% across the various classes.	Phosphatidylcholines	34-53	coagulation factor II, thrombin	Homo sapiens	213-221
6746652-7	1984	These results indicate that the 1-acyl-2-arachidonoyl species of phosphatidylcholine are not exclusively degraded by phospholipase A2 activity in thrombin-stimulated platelets and suggest that the differential compartmentation of molecular species of phosphatidylcholine according to their metabolic origins can influence their apparent susceptibility to hydrolysis.	Phosphatidylcholines	65-84	phospholipase A2 group IB	Homo sapiens	117-133
6746652-7	1984	These results indicate that the 1-acyl-2-arachidonoyl species of phosphatidylcholine are not exclusively degraded by phospholipase A2 activity in thrombin-stimulated platelets and suggest that the differential compartmentation of molecular species of phosphatidylcholine according to their metabolic origins can influence their apparent susceptibility to hydrolysis.	Phosphatidylcholines	65-84	coagulation factor II, thrombin	Homo sapiens	146-154
6549154-0	1984	Enhanced lipid peroxidation of erythrocyte membranes and phosphatidylcholine liposomes induced by a xanthine oxidase system in the presence of catalase.	Phosphatidylcholines	57-76	catalase	Homo sapiens	143-151
6746620-0	1984	Effect of apolipoprotein C-II on the temperature dependence of lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholines.	Phosphatidylcholines	106-126	apolipoprotein C2	Homo sapiens	10-29
6746620-0	1984	Effect of apolipoprotein C-II on the temperature dependence of lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholines.	Phosphatidylcholines	106-126	lipoprotein lipase	Homo sapiens	63-81
6746620-9	1984	We propose that the apo-C-II-mediated increase in the rate of the lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine is associated with transfer of a fatty acyl chain of the substrate or product to a more hydrophobic environment within the transition state complex.	Phosphatidylcholines	109-128	apolipoprotein C2	Homo sapiens	20-28
6746620-9	1984	We propose that the apo-C-II-mediated increase in the rate of the lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine is associated with transfer of a fatty acyl chain of the substrate or product to a more hydrophobic environment within the transition state complex.	Phosphatidylcholines	109-128	lipoprotein lipase	Homo sapiens	66-84
6428457-10	1984	Angiotensin II increased turnover of phosphatidylinositol and also phosphatidylcholine, as determined by incorporation of [14C]arachidonic acid.	Phosphatidylcholines	67-86	angiotensinogen	Rattus norvegicus	0-14
6746804-0	1984	High-performance liquid chromatography in the analysis of the products of phospholipase A hydrolysis of phosphatidylcholine.	Phosphatidylcholines	104-123	phospholipase A and acyltransferase 1	Homo sapiens	74-89
6464031-2	1984	T-2 toxin significantly elevated total liver lipids, triglycerides, free cholesterol, total phospholipids and phosphatidyl choline, whereas the level of sphingomyelin + lysophosphatidyl ethanolamine was reduced.	Phosphatidylcholines	110-130	brachyury 2	Rattus norvegicus	0-3
6743291-0	1984	Serum albumin enhances the uptake of [3H]cholesterol from phosphatidylcholine vesicles by cultured human fibroblasts.	Phosphatidylcholines	58-77	albumin	Homo sapiens	0-13
6373768-2	1984	Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine.	Phosphatidylcholines	341-360	insulin	Homo sapiens	58-65
6373768-2	1984	Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine.	Phosphatidylcholines	366-385	insulin	Homo sapiens	58-65
24458605-5	1984	It is concluded that galactolipids and phosphatidylcholine are responsible for the stability of CP1a, CP1 and CPa, respectively.	Phosphatidylcholines	39-58	carboxypeptidase A1	Homo sapiens	110-113
6723880-6	1984	Slight, but significant, differences were found between the B6 and D2 strains for the concentrations (microgram/100 mg wet weight) of sphingomyelin, phosphatidylcholine, and cerebrosides.	Phosphatidylcholines	149-168	defensin beta 2	Mus musculus	60-69
6326825-2	1984	Microsomal glucose-6-phosphatase from rat liver is activated by phosphatidylcholine but inhibited by lysophosphatidylcholine.	Phosphatidylcholines	64-83	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	11-32
6587389-1	1984	Spin-labeled analogs of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been used to study phospholipid transverse diffusion and asymmetry in the human erythrocyte membrane.	Phosphatidylcholines	24-43	spindlin 1	Homo sapiens	0-4
6426514-1	1984	A peptide (P-9) comprising amino acids 307 to 385 of bovine serum albumin induced the fusion of small unilamellar vesicles of phosphatidylcholine at low pH.	Phosphatidylcholines	126-145	exosome component 8	Homo sapiens	11-14
6427214-1	1984	Micellar, discoidal complexes of human apolipoproteins A-I, A-II, C-I, C-II, C-III-1, and C-III-2 with egg phosphatidylcholine (egg-PC) and cholesterol were prepared by the cholate dialysis method.	Phosphatidylcholines	107-126	NLR family pyrin domain containing 3	Homo sapiens	39-69
6715338-2	1984	This phospholipase A1 activity was relatively specific for phosphatidic acid; the addition of several other phospholipids in equimolar amounts did not have a significant effect on the hydrolysis of radiolabeled phosphatidic acid, and the specific activity for phosphatidic acid hydrolysis was 20-fold higher than that of the hydrolysis of phosphatidylcholine, phosphatidylethanolamine, or phosphatidylinositol under the conditions used.	Phosphatidylcholines	339-358	lipase H	Homo sapiens	5-21
6723644-2	1984	The phosphate transport protein (PTP) has been isolated from beef heart mitochondria in the presence of cardiolipin and reconstituted in asolectin and phosphatidylcholine vesicles.	Phosphatidylcholines	151-170	solute carrier family 25 member 3	Homo sapiens	4-31
6723644-2	1984	The phosphate transport protein (PTP) has been isolated from beef heart mitochondria in the presence of cardiolipin and reconstituted in asolectin and phosphatidylcholine vesicles.	Phosphatidylcholines	151-170	solute carrier family 25 member 3	Homo sapiens	33-36
6374960-0	1984	Phosphatidylcholine is the major phospholipid providing arachidonic acid for prostacyclin synthesis in thrombin-stimulated human endothelial cells.	Phosphatidylcholines	0-19	coagulation factor II, thrombin	Homo sapiens	103-111
6372966-0	1984	Glucagon inhibits phosphatidylcholine biosynthesis via the CDP-choline and transmethylation pathways in cultured rat hepatocytes.	Phosphatidylcholines	18-37	cut-like homeobox 1	Rattus norvegicus	59-62
6372966-2	1984	Under conditions in which insulin (100 nM) stimulated [3H]acetate incorporation into fatty acid almost twofold, synthesis of phosphatidylcholine via CDP-choline and from phosphatidylethanolamine were unaffected.	Phosphatidylcholines	125-144	cut-like homeobox 1	Rattus norvegicus	149-152
6145194-11	1984	While in adipose tissue the somatostatin only caused a strong increase in the specific activity of phosphatidylcholine.	Phosphatidylcholines	99-118	somatostatin	Mus musculus	28-40
6722104-1	1984	Phosphatidylcholine analogues containing a cis- parinaroyl chain at the sn-1, sn-2, or both sn-1 and sn-2 positions (1-PnA-PC, 2-PnA-PC, and diPnA -PC, respectively) have been used to investigate the lipid binding site of the phosphatidylcholine transfer protein (PC-TP) from bovine liver by fluorometric techniques.	Phosphatidylcholines	0-19	phosphatidylcholine transfer protein	Bos taurus	264-269
6367486-6	1984	Phospholipase A also plays a regulatory role in phosphatidylcholine metabolism because inhibition of this catabolic enzyme favors phospholipid accretion and kidney growth during potassium depletion, whereas stimulation of the enzyme leads to brisk phospholipid breakdown and a decrease in tissue mass during potassium repletion.	Phosphatidylcholines	48-67	phospholipase A and acyltransferase 1	Rattus norvegicus	0-15
6365172-1	1984	Phosphatidylcholine (PC) biosynthesis in cultured 3T3 fibroblasts was increased in varying degrees by these mitogenic growth factors: fetal bovine serum, insulin, 12-O-tetradecanoylphorbol-13-acetate, epidermal growth factor, vasopressin, fibroblast growth factor and insulin-like growth factors I and II.	Phosphatidylcholines	0-19	arginine vasopressin	Homo sapiens	226-237
6365172-1	1984	Phosphatidylcholine (PC) biosynthesis in cultured 3T3 fibroblasts was increased in varying degrees by these mitogenic growth factors: fetal bovine serum, insulin, 12-O-tetradecanoylphorbol-13-acetate, epidermal growth factor, vasopressin, fibroblast growth factor and insulin-like growth factors I and II.	Phosphatidylcholines	21-23	arginine vasopressin	Homo sapiens	226-237
6696448-1	1984	Complex formation between the phenobarbital-inducible form of rabbit liver microsomal cytochrome P-450 incorporated into phosphatidylcholine and detergent-solubilized cytochrome b5 is associated with a low-to-high spin transition of the former pigment.	Phosphatidylcholines	121-140	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	86-102
6321243-3	1984	After solubilization by Nonidet-P40 and purification by affinity chromatography and HPLC the isolated receptor was reconstituted into egg phosphatidylcholine vesicles by SM-2 Bio-Bead removal of the Nonidet-P40.	Phosphatidylcholines	138-157	SM2	Homo sapiens	170-174
6694756-3	1984	Here we show that the cytoskeletal protein known as band 4.1 specifically associates with the cytoplasmic domain of glycophorin on inside-out erythrocyte membrane vesicles and also with glycophorin reconstituted into phosphatidylcholine vesicles.	Phosphatidylcholines	217-236	erythrocyte membrane protein band 4.1	Homo sapiens	52-60
6436014-0	1984	A review of plasma apolipoprotein A-I interactions with phosphatidylcholines.	Phosphatidylcholines	56-76	apolipoprotein A1	Homo sapiens	19-37
6204218-1	1984	Human myelin basic protein isolated from the brains of individuals who died with multiple sclerosis was more potent in inducing the aggregation of egg phosphatidylcholine vesicles than was the basic protein isolated from the brains of normal individuals.	Phosphatidylcholines	151-170	myelin basic protein	Homo sapiens	6-26
6321096-4	1984	Incubation of rabbit young erythrocytes with phosphatidylcholine vesicles (liposomes) to obtain partial depletion of their membrane cholesterol, indicated that cholesterol depletion causes a statistically significant decrease of the (Na+,K+)-stimulated ATPase and acetylcholinesterase activities, but the NAD+ase activity remained almost unchanged.	Phosphatidylcholines	45-64	ACE-1	Oryctolagus cuniculus	264-284
6421314-1	1984	Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography.	Phosphatidylcholines	69-88	apolipoprotein A1	Homo sapiens	25-43
6421314-1	1984	Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography.	Phosphatidylcholines	69-88	apolipoprotein A1	Homo sapiens	45-52
6436014-1	1984	This review starts with a brief introduction to the properties of plasma high-density lipoproteins and their major protein component, apolipoprotein A-I, followed, in the following sections, by an account of experimental work from our laboratory on the interactions of apolipoprotein A-I with synthetic and natural phosphatidylcholines.	Phosphatidylcholines	315-335	apolipoprotein A1	Homo sapiens	269-287
6436014-2	1984	The spontaneous reactions of phosphatidylcholine vesicles with apolipoprotein A-I are described in terms of the methods of observation, the properties of the reaction products (vesicular or micellar complexes of protein and lipid), and the kinetic controlling factors in the formation of the micellar products.	Phosphatidylcholines	29-48	apolipoprotein A1	Homo sapiens	63-81
6724104-1	1984	Bovine luteal cytochrome P-450scc was purified and incorporated into artificial phosphatidylcholine vesicles.	Phosphatidylcholines	80-99	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	14-33
6206229-5	1984	Thus, the stimulated labeling in A23187-treated cells may occur secondary to the action of a phospholipase A2 that favors PC as a substrate.	Phosphatidylcholines	122-124	phospholipase A2 group IB	Rattus norvegicus	93-109
6708133-9	1984	As a consequence, the (3H)/(14C) ratio in total lipid and in isolated phosphatidylcholine and choline plasmalogen increased after CDP-choline treatment.	Phosphatidylcholines	70-89	cut-like homeobox 1	Rattus norvegicus	130-133
6316941-5	1983	Digestion of control liver membranes with exogenous phospholipase A2 decreased phosphatidylcholine and phosphatidylethanolamine levels by 50.6 and 51.2%, respectively, but increased lysophosphatidylcholine and lysophosphatidylethanolamine levels by 12- and 8.4-fold, respectively.	Phosphatidylcholines	79-98	phospholipase A2 group IB	Canis lupus familiaris	52-68
6643474-0	1983	Chain length dependence of phosphatidylcholine hydrolysis catalyzed by lipoprotein lipase.	Phosphatidylcholines	27-46	lipoprotein lipase	Bos taurus	71-89
6643474-2	1983	The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates.	Phosphatidylcholines	145-165	apolipoprotein C2	Bos taurus	14-33
6643474-2	1983	The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates.	Phosphatidylcholines	145-165	apolipoprotein C2	Bos taurus	35-42
6643474-2	1983	The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates.	Phosphatidylcholines	145-165	lipoprotein lipase	Bos taurus	63-81
6643474-2	1983	The effect of apolipoprotein C-II (apoC-II) on the bovine milk lipoprotein lipase (LpL)-catalyzed hydrolysis of a homologous series of saturated phosphatidylcholines was examined with respect to the fatty acyl chain length of the substrates.	Phosphatidylcholines	145-165	lipoprotein lipase	Bos taurus	83-86
6441310-9	1984	Phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol inhibited the phospholipase A2-induced platelet aggregation.	Phosphatidylcholines	0-19	phospholipase A2	Apis mellifera	85-101
6660509-1	1983	An alkyl ether analog of phosphatidylcholine was synthesized and used as a ligand to purify acid-extracted phospholipase A2 from bovine ileum smooth muscle by affinity chromatography in the presence of cholate.	Phosphatidylcholines	25-44	LOC104974671	Bos taurus	107-123
6686250-3	1983	The simultaneous addition of PC and ethanolamine also decreased serum apoA-I and cholesterol.	Phosphatidylcholines	29-31	apolipoprotein A1	Rattus norvegicus	70-76
6639953-1	1983	D-beta-Hydroxybutyrate dehydrogenase (D-3-hydroxybutyrate: NAD+ oxidoreductase, EC 1.1.1.30) is a lipid-dependent enzyme which has an absolute and specific requirement for phosphatidylcholine for function.	Phosphatidylcholines	172-191	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	64-78
6229251-1	1983	Transport of Pr3+ across phosphatidyl choline vesicles, as monitored by 31P nmr, is second-order in the crown ether carboxylic acid 2, as it is with respect to lasalocid (X-537 A).	Phosphatidylcholines	25-45	proteinase 3	Homo sapiens	13-16
6229251-1	1983	Transport of Pr3+ across phosphatidyl choline vesicles, as monitored by 31P nmr, is second-order in the crown ether carboxylic acid 2, as it is with respect to lasalocid (X-537 A).	Phosphatidylcholines	25-45	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	127-133
6680524-1	1983	The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains.	Phosphatidylcholines	70-89	phosphatidylethanolamine N-methyltransferase	Homo sapiens	17-59
6680524-1	1983	The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains.	Phosphatidylcholines	70-89	phosphatidylethanolamine N-methyltransferase	Homo sapiens	61-65
6680524-1	1983	The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains.	Phosphatidylcholines	91-93	phosphatidylethanolamine N-methyltransferase	Homo sapiens	17-59
6680524-1	1983	The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains.	Phosphatidylcholines	91-93	phosphatidylethanolamine N-methyltransferase	Homo sapiens	61-65
6316933-5	1983	Reactivation of phosphatidylcholine synthesis in chlorophenylthio-cyclic AMP-supplemented cells with oleate was accompanied by conversion of CTP: phosphocholine cytidylyltransferase into the membrane-bound form, since these cells released the enzyme more slowly after treatment with digitonin.	Phosphatidylcholines	16-35	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	141-181
6643460-7	1983	The incubation of Factor V with Factor Xa in the presence of phosphatidylcholine/phosphatidylserine vesicles, CaCl2, and DAPA resulted in a time-dependent increase in cofactor activity.	Phosphatidylcholines	61-80	coagulation factor X	Homo sapiens	32-41
6680049-4	1983	Membranes prepared from phosphatidylcholines having a single cis double bond at different positions along the sn-2 acyl chain showed roughly the same changes of microviscosity or chain order upon incorporation of cholesterol.	Phosphatidylcholines	24-44	solute carrier family 38 member 5	Homo sapiens	110-114
6644446-5	1983	Phosphatidylcholine and phosphatidylethanolamine were digested by phospholipase A2.	Phosphatidylcholines	0-19	phospholipase A2 group IB	Homo sapiens	66-82
6885797-10	1983	The apparent Km for AdoMet at pH 10.25 for the conversion of PE to PME was 58 microM, PME to PDE was 65 microM, and PDE to PC was 96 microM.	Phosphatidylcholines	123-125	methionine adenosyltransferase 1A	Rattus norvegicus	20-26
6352808-1	1983	The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min.	Phosphatidylcholines	108-127	interleukin 6	Homo sapiens	34-38
6626154-2	1983	absorption spectrum of retinyl phosphate (Ret-P) solubilized in Triton X-100 micelles, phosphatidylcholine liposomes or rat liver microsomes exhibited a shift from the maximum of 330 nm to 287 nm.	Phosphatidylcholines	87-106	ret proto-oncogene	Rattus norvegicus	42-45
6885797-13	1983	The apparent Km for AdoMet was also estimated for the conversion of exogenous PME to PDE (50 microM) and exogenous PDE to PC (45 microM).	Phosphatidylcholines	122-124	methionine adenosyltransferase 1A	Rattus norvegicus	20-26
6349697-5	1983	The presence of low doses of insulin (10-25 microunits/ml) caused a significant increase in the incorporation of glucose into both surfactant and residual phosphatidylcholine.	Phosphatidylcholines	155-174	insulin	Homo sapiens	29-36
6309244-0	1983	Stimulation of hepatic phosphatidylcholine biosynthesis in rats fed a high cholesterol and cholate diet correlates with translocation of CTP: phosphocholine cytidylyltransferase from cytosol to microsomes.	Phosphatidylcholines	23-42	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	137-177
6349697-6	1983	Insulin at levels of 100 microunits/ml or higher resulted in a significant decrease in glucose incorporation into both phosphatidylcholine fractions.	Phosphatidylcholines	119-138	insulin	Homo sapiens	0-7
6349697-8	1983	The addition of 400 microunits/ml of insulin to media containing 20 mM glucose, however, resulted in a 20% decrease in choline incorporation into surfactant phosphatidylcholine but had no effect on choline incorporation into residual phosphatidylcholine.	Phosphatidylcholines	157-176	insulin	Homo sapiens	37-44
6349697-8	1983	The addition of 400 microunits/ml of insulin to media containing 20 mM glucose, however, resulted in a 20% decrease in choline incorporation into surfactant phosphatidylcholine but had no effect on choline incorporation into residual phosphatidylcholine.	Phosphatidylcholines	234-253	insulin	Homo sapiens	37-44
6882789-11	1983	Palmitate was cleaved from both C-1 and C-2 positions of phosphatidylcholine.	Phosphatidylcholines	57-76	complement C2	Cavia porcellus	40-43
6411128-2	1983	Each purified apolipoprotein A-I species was individually incorporated into phosphatidylcholine/cholesterol vesicles by the cholate dialysis method to form proteoliposome common substrates (apolipoprotein A-I/phosphatidylcholine/cholesterol molar ratio of 1:250:12.5) for the enzyme activity assay.	Phosphatidylcholines	76-95	apolipoprotein A1	Homo sapiens	14-32
6411702-2	1983	All the phosphatidylcholine molecules in those particles were readily digested by phospholipase A2 while only the molecules in the outer leaflet of phosphatidylcholine unilamellar vesicles were hydrolyzed under the same conditions.	Phosphatidylcholines	8-27	phospholipase A2 group IB	Homo sapiens	82-98
6411128-2	1983	Each purified apolipoprotein A-I species was individually incorporated into phosphatidylcholine/cholesterol vesicles by the cholate dialysis method to form proteoliposome common substrates (apolipoprotein A-I/phosphatidylcholine/cholesterol molar ratio of 1:250:12.5) for the enzyme activity assay.	Phosphatidylcholines	209-228	apolipoprotein A1	Homo sapiens	14-32
6863928-6	1983	Analysis of specific CsA uptake by cultured human kidney cells and phospholipid vesicles (1:1 molar ratio of phosphatidylcholine:cholesterol) showed both these targets to display a single, low affinity binding site (KD = 1 X 10(-7) M and 2 X 10(-8) M, respectively).	Phosphatidylcholines	109-128	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	21-24
6871217-1	1983	By making use of the capacity of phospholipase A2 to degrade selectively the phospholipid in the outer half of the lipid bilayer of small unilamellar phospholipid/cholesterol vesicles without affecting the retention of a vesicle-encapsulated solute, we demonstrated that the exchange of phosphatidylcholine between such vesicles and human high density lipoprotein involves exclusively the phosphatidylcholine present in the outer monolayer of the vesicle membrane.	Phosphatidylcholines	287-306	phospholipase A2 group IB	Homo sapiens	33-49
6871217-1	1983	By making use of the capacity of phospholipase A2 to degrade selectively the phospholipid in the outer half of the lipid bilayer of small unilamellar phospholipid/cholesterol vesicles without affecting the retention of a vesicle-encapsulated solute, we demonstrated that the exchange of phosphatidylcholine between such vesicles and human high density lipoprotein involves exclusively the phosphatidylcholine present in the outer monolayer of the vesicle membrane.	Phosphatidylcholines	389-408	phospholipase A2 group IB	Homo sapiens	33-49
6882441-1	1983	Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly.	Phosphatidylcholines	101-120	coagulation factor X	Homo sapiens	31-45
6882441-1	1983	Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly.	Phosphatidylcholines	122-124	coagulation factor X	Homo sapiens	31-45
6863295-7	1983	At various time intervals, samples were taken and treated with phospholipase A2, which selectively degrades the PC in the outer monolayer.	Phosphatidylcholines	112-114	phospholipase A2 group IB	Homo sapiens	63-79
6134645-1	1983	Chlorpromazine (25 microM) and trifluoperazine (25 microM) inhibited by 5-fold the activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme for phosphatidylcholine biosynthesis, in rat liver cytosol.	Phosphatidylcholines	165-184	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	95-134
6860707-1	1983	Lipid peroxidation induced through cytochrome P-450 activation of cumene hydroperoxide, linolenic acid hydroperoxide and peroxidized phosphatidylcholine in rat liver microsomes is markedly inhibited by either NADH or NADPH.	Phosphatidylcholines	133-152	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	35-51
6631221-3	1983	Approximately 28% of the HDL phosphatidylcholine was hydrolyzed by the hepatic lipase but no change was detected in the cholesterol or apoprotein content of the HDL compared to HDL incubated with heat-inactivated hepatic lipase.	Phosphatidylcholines	29-48	lipase C, hepatic type	Rattus norvegicus	71-85
6873198-2	1983	Liposomes were prepared from various conventional lipids and from a novel photopolymerizable phosphatidylcholine derivative (DPL, bis[1,2-(methacryloyloxy)dodecanoyl]-L-alpha-phosphatidylcholine).	Phosphatidylcholines	93-112	prion like protein doppel	Homo sapiens	125-128
6863389-4	1983	Since this was observed with glycerol, choline, and orthophosphate labelings, and not with methyl labeling, it appears that the CDP-choline plus diacylglycerol pathway rather than the phosphatidylethanolamine to PC pathway was augmented.	Phosphatidylcholines	212-214	cut like homeobox 1	Homo sapiens	128-131
6615923-1	1983	Superoxide dismutase from erythrocytes and ceruloplasmin of serum inhibit the oxidation of phosphatidylcholine and phosphatidylethanolamine solubilized by cholate.	Phosphatidylcholines	91-110	ceruloplasmin	Homo sapiens	43-56
6688442-0	1983	Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism.	Phosphatidylcholines	43-62	lipoprotein lipase	Cavia porcellus	0-18
6859870-7	1983	Furthermore, lipid hydroperoxides formed by subjecting phosphatidylcholine liposomes to iron ascorbate-induced peroxidation, or those present in aged liposomes, were effectively reduced by glutathione peroxidase when phospholipase A2 was present in the assay.	Phosphatidylcholines	55-74	phospholipase A2 group IB	Rattus norvegicus	217-233
6304057-0	1983	Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis.	Phosphatidylcholines	132-151	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	37-76
6688442-14	1983	Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism.	Phosphatidylcholines	43-62	lipoprotein lipase	Cavia porcellus	0-18
6303434-8	1983	Certain of the phosphatidylcholine replacements produced changes in palmitoyl-CoA hydrolase, NADPH-dependent lipid peroxidase, glucose-6-phosphatase and UDPglucuronyl transferase activities, but they did not closely correlate with the alterations in acyl-CoA:cholesterol acyltransferase activity.	Phosphatidylcholines	15-34	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	127-148
6303406-6	1983	Order parameter values of spin labels in liposomes containing brain phosphatidylcholine and phosphatidylethanolamine increased in parallel with increases in plasmenylethanolamine concentrations, indicating that fluidity was decreasing.	Phosphatidylcholines	68-87	spindlin 1	Rattus norvegicus	26-30
6849950-3	1983	In the presence of liver lipase serum triacylglycerol and phosphatidylcholine were hydrolyzed.	Phosphatidylcholines	58-77	lipase G, endothelial type	Rattus norvegicus	25-31
6852018-0	1983	Hydrolysis of mixed monomolecular films of phosphatidylcholine/triacylglycerol by pancreatic phospholipase A2.	Phosphatidylcholines	43-62	phospholipase A2 group IB	Homo sapiens	93-109
6853529-0	1983	Action of lipoprotein lipase on mixed triacylglycerol/phosphatidylcholine monolayers.	Phosphatidylcholines	54-73	lipoprotein lipase	Homo sapiens	10-28
6572961-1	1983	Rat brain synaptosomes contain enzymes, phosphatidylethanolamine N-methyltransferase(s) (EC 2.1.1.17), that catalyze the methylation of endogenous phosphatidylethanolamine to form its mono-, di-, and trimethyl (i.e., phosphatidylcholine) derivatives.	Phosphatidylcholines	217-236	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	40-84
6840096-1	1983	The lipid binding site of the phosphatidylcholine transfer protein from bovine liver has been investigated by use of phosphatidylcholine analogs which carry a diazirinophenoxy group linked to the omega-carbon of either the sn-2-[1-14C]hexanoyl (PC I) or sn-2-[1-14C]undecanoyl chain (PC II).	Phosphatidylcholines	30-49	serpin family A member 5	Bos taurus	245-249
6302691-5	1983	Bradykinin caused a release of arachidonic acid from methylated phospholipids (phosphatidylcholine) and phosphatidylinositol.	Phosphatidylcholines	79-98	kininogen 1	Homo sapiens	0-10
6849876-0	1983	Calorimetric and fluorescence characterization of interactions between cytochrome b5 and phosphatidylcholine bilayers.	Phosphatidylcholines	89-108	cytochrome b5 type A	Homo sapiens	71-84
6838196-0	1983	Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile salt mixed micelles: kinetic studies in a lecithin-sodium cholate system.	Phosphatidylcholines	60-79	phospholipase A2 group IB	Homo sapiens	19-35
6311617-5	1983	Hemoglobin encapsulated in egg phosphatidylcholine vesicles converts to methemoglobin within 2 days at 4 degrees C. By contrast, when a mixture of dimyristoyl phosphatidylcholine, cholesterol and dicetyl phosphate is used there is no acceleration in methemoglobin formation, and the preparation is stable for at least 14 days at 4 degrees C.	Phosphatidylcholines	31-50	hemoglobin subunit gamma 2	Homo sapiens	72-85
6298234-2	1983	Elution of purified receptor (NGF receptor) was accomplished with 0.15 M NaCl, pH 11.0, containing phosphatidylcholine and octylglucoside.	Phosphatidylcholines	99-118	nerve growth factor receptor	Homo sapiens	30-42
6838196-1	1983	Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in bile salt lecithin mixed micelles has been studied, utilizing a series of assay mixtures for which the micellar size, weight, and composition had been experimentally determined.	Phosphatidylcholines	60-79	phospholipase A2 group IB	Homo sapiens	19-35
6856033-4	1983	At short times after the isotope administration a rapid labeling of phosphatidylcholine was detected, when cells were incubated with CDP-choline.	Phosphatidylcholines	68-87	cut like homeobox 1	Homo sapiens	133-136
6833402-1	1983	Liposomes made by sonication of egg yolk phosphatidyl choline support the proliferation of low-density bovine vascular and corneal endothelial cells, and vascular smooth muscle cells maintained on basement laminacoated dishes and exposed to a defined medium supplemented with transferrin.	Phosphatidylcholines	41-61	serotransferrin	Bos taurus	276-287
6304446-2	1983	The labeling of choline glycerophospholipid (CGP) from radioactive cytidine-5"-diphosphate choline (CDP-choline) in vitro shows a maximum at pH 8.0 (using Hepes [4-(2-hydroxyethyl)-piperazine-1-ethane-2-sulfonic acid] as a buffer) and is stimulated by Mn2+, Mg2+ and diacylglycerol.	Phosphatidylcholines	45-48	cut like homeobox 1	Homo sapiens	100-103
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	84-103	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	84-103	membrane metalloendopeptidase	Homo sapiens	198-201
16662890-6	1983	When [(14)C][unk] MME was supplied, a small amount was hydrolyzed to the free base but the major fate was conversion to [unk] DME, [unk] choline, free choline, and betaine; label also accumulated slowly in phosphatidylcholine.	Phosphatidylcholines	206-225	unk zinc finger	Homo sapiens	13-16
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	84-103	unk zinc finger	Homo sapiens	193-196
16662890-6	1983	When [(14)C][unk] MME was supplied, a small amount was hydrolyzed to the free base but the major fate was conversion to [unk] DME, [unk] choline, free choline, and betaine; label also accumulated slowly in phosphatidylcholine.	Phosphatidylcholines	206-225	membrane metalloendopeptidase	Homo sapiens	18-21
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	84-103	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	84-103	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	unk zinc finger	Homo sapiens	28-31
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	membrane metalloendopeptidase	Homo sapiens	198-201
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	unk zinc finger	Homo sapiens	193-196
16662890-7	1983	Label from supplied [(14)C][unk] choline entered choline and betaine rapidly, while phosphatidylcholine labeled only slowly and to a small extent.These results are consistent with the pathway [unk] MME --&gt;[unk] DME --&gt; [unk] choline --&gt; choline --&gt; --&gt; betaine, with a minor side branch leading from [unk] choline into phosphatidylcholine.	Phosphatidylcholines	334-353	unk zinc finger	Homo sapiens	193-196
6860684-0	1983	Transfer of cholesteryl linoleyl ether from phosphatidylcholine and phosphatidylethanolamine liposomes to cultured cells catalyzed by lipoprotein lipase.	Phosphatidylcholines	44-63	lipoprotein lipase	Homo sapiens	134-152
6401716-7	1983	It is concluded that the mechanisms of interaction between apolipoprotein A-I and either bovine brain sphingomyelin or phosphatidylcholines are similar, but that the nature of the protein-lipid interactions with BBSM are such as to produce larger and more stable complexes than are observed with the phosphatidylcholines.	Phosphatidylcholines	119-139	APOAI	Bos taurus	59-77
6831908-2	1983	Bee venom phospholipase A2 which attacks only phosphatidylcholine (PC) in the intact erythrocyte results in inhibition of cryohemolysis produced by both hypertonic sodium chloride and sucrose.	Phosphatidylcholines	46-65	phospholipase A2 group IB	Homo sapiens	10-26
6831908-2	1983	Bee venom phospholipase A2 which attacks only phosphatidylcholine (PC) in the intact erythrocyte results in inhibition of cryohemolysis produced by both hypertonic sodium chloride and sucrose.	Phosphatidylcholines	67-69	phospholipase A2 group IB	Homo sapiens	10-26
6297895-1	1983	Interactions of band 4.1 with mixed phospholipid membranes [phosphatidylserine (PtdSer), phosphatidylethanolamine, phosphatidylcholine, etc.]	Phosphatidylcholines	115-134	erythrocyte membrane protein band 4.1	Homo sapiens	16-24
6337128-1	1983	The Saccharomyces cerevisiae opi3-3 mutant was shown to be defective in the synthesis of phosphatidylcholine via methylation of phosphatidylethanolamine.	Phosphatidylcholines	89-108	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	29-35
6337128-5	1983	When grown in the absence of exogenous choline, the opi3-3 mutant had a phospholipid composition consisting of 2 to 3% phosphatidylcholine compared with 40 to 50% in wild-type strains.	Phosphatidylcholines	119-138	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	52-58
6337128-11	1983	Based upon incorporation of choline into phosphatidylcholine, it is concluded that the opi3-3 mutant has no defect in the synthesis of phosphatidylcholine from exogenous choline.	Phosphatidylcholines	41-60	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	87-93
6130787-2	1982	We show that the binding constant for cholesterol is considerably less than that for phosphatidylcholine, so that cholesterol is effectively excluded from the phospholipid annulus around the ATPase.	Phosphatidylcholines	85-104	dynein axonemal heavy chain 8	Homo sapiens	191-197
6761591-2	1982	Lysolecithin, one of the hydrolytic products of phosphatidyl choline by phospholipase A was prepared and found able to hemolyse human red blood cells and "clear" rat skin and muscle homogenates.	Phosphatidylcholines	48-68	phospholipase A and acyltransferase 1	Homo sapiens	72-87
6297604-5	1983	Exposure of isolated type II cells to the phospholipase A2 inhibitors 4-bromophenacylbromide or quinacrine dihydrochloride led to a decreased synthesis of total phosphatidylcholines from various labelled precursors.	Phosphatidylcholines	161-181	phospholipase A2 group IB	Rattus norvegicus	42-58
6684464-3	1983	--This radioactivity is detected by the labelling of phosphatidyl-choline and endogenous sphingomyelin from CDP-choline.	Phosphatidylcholines	53-73	cut-like homeobox 1	Rattus norvegicus	108-111
6850989-5	1983	Cytochrome P-450 was phosphorylated when added as sole component and also when in the presence of P-450 reductase and phosphatidylcholine.	Phosphatidylcholines	118-137	cytochrome P-450	Oryctolagus cuniculus	0-16
6129245-1	1982	The membrane-permeable photoactivatable reagent 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine was used to selectively label the hydrophobic domain of the amphipathic form of gamma-glutamyl transpeptidase reconstituted into phosphatidylcholine vesicles.	Phosphatidylcholines	227-246	gamma-glutamyltransferase 1	Rattus norvegicus	178-207
6818987-1	1982	Micellar complexes with different phosphatidylcholine (PC) compositions were prepared by the dialysis of PC-cholesterol dispersions with cholate in the presence of human apolipoprotein A-I (apo A-I).	Phosphatidylcholines	55-57	apolipoprotein A1	Homo sapiens	170-188
6817809-3	1982	In vitro, the association of apolipoprotein A-I with physiological phosphatidylcholines can be catalyzed by mixing the protein and lipid with sodium cholate, which is removed by chromatography.	Phosphatidylcholines	67-87	apolipoprotein A1	Homo sapiens	29-47
7150628-2	1982	Phosphatidylcholines and phosphatidylethanolamines with an oleoyl or a docosahexaenoyl residue at C-2 increased, while many of the species with a linoleoyl or an arachidonoyl residue at C-2 decreased throughout the experiment.	Phosphatidylcholines	0-20	complement C2	Rattus norvegicus	98-101
7150631-2	1982	The lipoprotein lipase-catalyzed hydrolysis of triacylglycerol was determined in a lipid monolayer containing egg phosphatidylcholine and tri[14C]oleoylglycerol.	Phosphatidylcholines	114-133	lipoprotein lipase	Bos taurus	4-22
7159628-0	1982	[Rapid transmembrane migration of phosphatidylcholine under the influence of cytochrome P-450].	Phosphatidylcholines	34-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-94
7150631-6	1982	The addition of sphingomyelin to the phosphatidylcholine monolayer decreased lipoprotein lipase activity.	Phosphatidylcholines	37-56	lipoprotein lipase	Bos taurus	77-95
7165723-10	1982	This stimulation of acidic phospholipase A activity by chloroquine appears to be coupled to the synthesis of disaturated phosphatidylcholine, thereby enhancing remodelling of phosphatidylcholine synthesized de novo.	Phosphatidylcholines	121-140	phospholipase A and acyltransferase 1	Rattus norvegicus	27-42
7159628-1	1982	The phosphatidylcholine exchange protein and bee venom phospholipase A2 were used to estimate the phosphatidylcholine accessibility in proteoliposome-containing cytochrome P-450.	Phosphatidylcholines	4-23	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	161-177
6219744-5	1982	Potency of anti-CaM drugs was generally greater on the enzyme reconstituted in asolectin vesicles than on the enzyme reconstituted in phosphatidylcholine vesicles, either in the presence or absence of CaM.	Phosphatidylcholines	134-153	calmodulin 1	Homo sapiens	16-19
7159628-3	1982	Incorporation of cytochrome P-450 into the liposomes resulted in a complete accessibility of phosphatidylcholine for the phosphatidylcholine exchange protein and phospholipase A2.	Phosphatidylcholines	93-112	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-33
7160029-6	1982	In contrast to these two proteins, the presence of synexin in the solution did enhance the Ca2+-induced aggregation of phosphatidylserine vesicles, but did not seem to affect the degree of Ca2+-induced fusion between phosphatidylserine/phosphatidylcholine (1:1) and phosphatidylserine vesicles and monolayer membranes.	Phosphatidylcholines	236-255	annexin A7	Homo sapiens	51-58
7159628-3	1982	Incorporation of cytochrome P-450 into the liposomes resulted in a complete accessibility of phosphatidylcholine for the phosphatidylcholine exchange protein and phospholipase A2.	Phosphatidylcholines	93-112	phospholipase A2 group IB	Rattus norvegicus	162-178
7159628-5	1982	It was concluded that cytochrome P-450 induces rapid transmembrane translocation of phosphatidylcholine with tau 1/2 less than 20 min.	Phosphatidylcholines	84-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-38
7159628-6	1982	It is proposed that cytochrome P-450 may be responsible for rapid flip-flop of phosphatidylcholine in rat liver microsomes.	Phosphatidylcholines	79-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-36
6819423-5	1982	Radioactivity of phosphatidylcholine (2-arachidonyl-1-14C) suspended in the plasma of PRP was incorporated into 12-HETE but not to TXB2, indicating again that only lipoxygenase can utilize AA derived from plasma phospholipids.	Phosphatidylcholines	17-36	proline rich protein 2-like 1	Rattus norvegicus	86-89
7142994-3	1982	NGF stimulates the incorporation of 32PO4 into other lipids, such as phosphatidylcholine, to a lesser extent.	Phosphatidylcholines	69-88	nerve growth factor	Homo sapiens	0-3
6818955-0	1982	Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.	Phosphatidylcholines	14-33	arginine vasopressin	Rattus norvegicus	47-58
27519437-10	1982	It appears that microsomal glucose-6-phosphatase is inhibited by increased phosphatidylcholine saturation.	Phosphatidylcholines	75-94	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	27-48
6818955-1	1982	The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine.	Phosphatidylcholines	169-188	arginine vasopressin	Rattus norvegicus	25-36
7171594-1	1982	Glycophorin A, the major sialoglycoprotein of the human erythrocyte membrane, has been incorporated in small unilamellar vesicles containing phosphatidylcholine and phosphatidylethanolamine in varying proportions.	Phosphatidylcholines	141-160	glycophorin A (MNS blood group)	Homo sapiens	0-13
6185153-11	1982	The reduced synthesis of phosphatidylcholine strongly correlated with inhibition of CTP:phosphocholine cytidylyltransferase activity.	Phosphatidylcholines	25-44	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	84-123
6295447-1	1982	Rotational diffusion of rhodopsin in reconstituted membranes of phosphatidylcholines of various alkyl chain lengths has been measured by using saturation-transfer electron spin resonance spectroscopy as a function of temperature and lipid/rhodopsin mole ratio.	Phosphatidylcholines	64-84	rhodopsin	Homo sapiens	24-33
7139847-2	1982	Furthermore, it was found that at the phase transition temperature the phosphatidylcholine bilayers are subject to rapid hydrolysis by pancreatic phospholipase A2 whereas phosphatidylethanolamine bilayers are not.	Phosphatidylcholines	71-90	phospholipase A2 group IB	Homo sapiens	146-162
7181862-2	1982	We have found, however, that the activity of microsomal glutathione S-transferase is increased 5-fold after treatment with small unilamellar vesicles made from phosphatidylcholine.	Phosphatidylcholines	160-179	hematopoietic prostaglandin D synthase	Rattus norvegicus	56-81
7181862-5	1982	When this fraction of the microsomal extract is reconstituted in the form of small unilamellar vesicles, it inhibits microsomal glutathione S-transferase that had been activated by prior treatment with small unilamellar vesicles of pure phosphatidylcholine, but does not affect the activity of unactivated microsomal glutathione S-transferase.	Phosphatidylcholines	237-256	hematopoietic prostaglandin D synthase	Rattus norvegicus	128-153
7126623-2	1982	[3H]Cholesteryl esters were formed by endogenous HDL3/VHDL enzyme (d greater than 1.125 g/ml) following incubation with mixed vesicles of phosphatidylcholine, unesterified cholesterol and 3H-labelled unesterified cholesterol.	Phosphatidylcholines	138-157	HDL3	Homo sapiens	49-53
7142817-1	1982	Phosphatidylcholine synthesis from CDP-[methyl-14C]choline and membrane-bound diacyl-[U-14C]-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes.	Phosphatidylcholines	0-19	cut-like homeobox 1	Rattus norvegicus	35-38
7142127-10	1982	It catalyzed benzo(a)pyrene hydroxylation with a turnover rate of 3.63 nmol/nmol of cytochrome P-450 in a reconstituted system containing NADPH-cytochrome c reductase and phosphatidylcholine, whereas little myristate hydroxylation activity was detected.	Phosphatidylcholines	171-190	cytochrome P-450	Oryctolagus cuniculus	84-100
6286659-2	1982	Binding of human fibroblast beta-hexosaminidase B to receptors reconstituted into phosphatidylcholine liposomes was 1) specifically inhibited by mannose 6-phosphate, but not mannose 1-phosphate or glucose 6-phosphate, and 2) had properties similar to the previously reported binding of enzyme to receptors on cell surfaces and isolated membranes.	Phosphatidylcholines	82-101	O-GlcNAcase	Homo sapiens	28-47
7126704-0	1982	[Lipid dependence of the activity of cytochrome P-450 from microsomes of rat liver by the phosphatidylcholine transfer protein from bovine liver].	Phosphatidylcholines	90-109	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	37-53
7126704-1	1982	The lipid dependence of hydroxylase and demethylase activities of microsomal cytochrome P-450 was studied, using purified phosphatidylcholine transfer protein from bovine liver.	Phosphatidylcholines	122-141	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
7126704-2	1982	In the presence of this protein exogeneous phosphatidylcholine was shown to reactivate cytochrome P-450 inactivated earlier with lysophosphatidylcholine.	Phosphatidylcholines	43-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-103
6810941-5	1982	The binding of 125I-labeled HDL3 to the rat liver plasma membranes was competitively inhibited by unlabeled human HDL3, rat HDL, HDL from nephrotic rats enriched in apolipoprotein A-I and phosphatidylcholine complexes of human apolipoprotein A-I, but not by human or rat LDL, free human apolipoprotein A-I or phosphatidylcholine vesicles.	Phosphatidylcholines	188-207	HDL3	Homo sapiens	28-32
6214785-5	1982	This effect of synexin was drastically inhibited by including 25% phosphatidylcholine (mol/mol) in the vesicle membrane.	Phosphatidylcholines	66-85	annexin A7	Homo sapiens	15-22
6810941-6	1982	Human 125I-labeled apolipoprotein A-I complexed with egg phosphatidylcholine bound to rat liver plasma membranes with high affinity and saturability, and the binding constants were similar to those of human 125I-labeled HDL3.	Phosphatidylcholines	57-76	apolipoprotein A1	Homo sapiens	19-37
6810947-8	1982	Deoxycholate also induces slightly the disappearance of some 14C radioactivity from phosphatidylethanolamine and phosphatidylcholine, which might reflect activation of phospholipase A2.	Phosphatidylcholines	113-132	phospholipase A2 group IB	Rattus norvegicus	168-184
6126513-3	1982	When this microsomal extract was combined with liposomes composed of cholesterol and egg phosphatidylcholine, the ACAT activity increased 5.4- to 6.7-fold.	Phosphatidylcholines	89-108	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	114-118
7091020-6	1982	Concentrations of 20 to 22 carbon polyunsaturated fatty acids in the erythrocyte membrane phosphatidylethanolamine and phosphatidylcholine of SMA and Enfamil-fed infants were similar despite very significant differences in the amount of dietary 18 carbon precursor.	Phosphatidylcholines	119-138	survival of motor neuron 1, telomeric	Homo sapiens	142-145
6126513-5	1982	ACAT activity increased 2.9-fold when the phosphatidylcholine content of the liposomes was raised from 0.5 to 5.0 mumol/mg microsomal protein.	Phosphatidylcholines	42-61	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	0-4
6126513-8	1982	ACAT activity was five times higher when the liposomes were prepared from dioleoylphosphatidylcholine than from saturated phosphatidylcholines, including hydrogenated egg yolk, dimyristoyl or dipalmitoyl phosphatidylcholine.	Phosphatidylcholines	122-142	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	0-4
6126513-9	1982	Likewise, the ACAT activity with liposomes made from soybean or egg yolk phosphatidylcholine was almost 3.5-fold greater than with those prepared from the saturated phosphatidylcholines.	Phosphatidylcholines	73-92	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	14-18
6126513-9	1982	Likewise, the ACAT activity with liposomes made from soybean or egg yolk phosphatidylcholine was almost 3.5-fold greater than with those prepared from the saturated phosphatidylcholines.	Phosphatidylcholines	165-185	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	14-18
6806255-1	1982	Mouse peritoneal macrophages have a phospholipase A2 activity which is optimally active at pH 8.5 (PLA8.5), requires 2 mM Ca2+ and is capable of hydrolyzing arachidonic acid from phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	179-198	phospholipase A2, group IB, pancreas	Mus musculus	36-52
6809043-1	1982	Effect of apolipoprotein A-I on phosphatidylcholine polar group conformation as studied by proton nuclear magnetic resonance.	Phosphatidylcholines	32-51	apolipoprotein A1	Homo sapiens	10-28
7085608-4	1982	Elevated platelet cholesterol content affected thrombin-induced changes in platelet phospholipids: (a) hydrolysis of PC was more sensitive to thrombin and was markedly enhanced over a wide range of thrombin concentrations (0.1-2 units/ml); (b) hydrolysis of phosphatidylinositol (PI) was increased at thrombin concentrations greater than or equal to 0.2 unit/ml.	Phosphatidylcholines	117-119	coagulation factor II, thrombin	Homo sapiens	47-55
7085608-6	1982	At higher thrombin concentrations (0.2-2 units/ml) it reflected enhanced hydrolysis of predominantly PC, but also PI.	Phosphatidylcholines	101-103	coagulation factor II, thrombin	Homo sapiens	10-18
7076675-0	1982	Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathway.	Phosphatidylcholines	101-120	cut like homeobox 1	Homo sapiens	129-132
6802836-0	1982	Reaction of human lecithin cholesterol acyltransferase with synthetic micellar complexes of apolipoprotein A-I, phosphatidylcholine, and cholesterol.	Phosphatidylcholines	112-131	lecithin-cholesterol acyltransferase	Homo sapiens	18-54
7136004-10	1982	Alterations in hepatic drug metabolism are possibly mediated via changes in microsomal phospholipids and/or the cytochrome P-450 spin-state equilibrium as as pregnancy was associated with a decrease in (a) microsomal total phospholipids, (b) the phosphatidylcholine to phosphatidylethanolamine ratio and (c) the high-spin form of ferricytochrome P-450.	Phosphatidylcholines	246-265	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-128
6802835-0	1982	Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions.	Phosphatidylcholines	52-72	apolipoprotein A1	Homo sapiens	28-46
7104306-5	1982	The half-time for dipalmitoyl-PC exchange from HDL3 to LDL is 5 +/- h, indicating that the flux of PC is much lower than that of cholesterol.	Phosphatidylcholines	30-32	HDL3	Homo sapiens	47-51
7093220-3	1982	The addition of [3H]methionine to cells that were grown in 1 mM dimethylethanolamine efficiently radiolabeled phosphatidylcholine (by methylation of phosphatidyldimethylethanolamine) and sphingomyelin but not phosphocholine or CDP-choline.	Phosphatidylcholines	110-129	cut like homeobox 1	Homo sapiens	227-230
6802836-1	1982	Micellar, discoidal complexes of human apolipoprotein A-I (apo A-I) with phosphatidylcholines and cholesterol, prepared by the method described in the preceding paper (Matz, C. M., and Jonas, A.	Phosphatidylcholines	73-93	apolipoprotein A1	Homo sapiens	39-57
6802836-1	1982	Micellar, discoidal complexes of human apolipoprotein A-I (apo A-I) with phosphatidylcholines and cholesterol, prepared by the method described in the preceding paper (Matz, C. M., and Jonas, A.	Phosphatidylcholines	73-93	apolipoprotein A1	Homo sapiens	59-66
7061453-0	1982	Kinetics of the incorporation of adrenal cytochrome P-450scc into phosphatidylcholine vesicles.	Phosphatidylcholines	66-85	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	41-60
6799515-9	1982	These results suggest that the CoA-mediated, ATP-independent breakdown of phosphatidylcholine and transfer of arachidonic acid is catalyzed by the acyl-CoA:lysophosphatide acyltransferase operating in reverse.	Phosphatidylcholines	74-93	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	31-34
7074076-4	1982	At 37 degrees C and an internal concentration of 30 mM Ca2+, the initial flux for rhodopsin-egg phosphatidylcholine membrane vesicles was 0.25 +/- 0.11 Ca2+ per bleached rhodopsin per s. Similar fluxes were observed for the release of Co2+, Mn2+, Ni2+, and Mg2+.	Phosphatidylcholines	96-115	rhodopsin	Homo sapiens	82-91
7074076-4	1982	At 37 degrees C and an internal concentration of 30 mM Ca2+, the initial flux for rhodopsin-egg phosphatidylcholine membrane vesicles was 0.25 +/- 0.11 Ca2+ per bleached rhodopsin per s. Similar fluxes were observed for the release of Co2+, Mn2+, Ni2+, and Mg2+.	Phosphatidylcholines	96-115	rhodopsin	Homo sapiens	170-179
6799515-6	1982	Addition of CoA and lysophosphatidylethanolamine to prelabeled thymocyte homogenates induced a fast breakdown of phosphatidylcholine and transfer of arachidonic acid to phosphatidylethanolamine, as in seen during incubations of intact thymocytes or macrophages.	Phosphatidylcholines	113-132	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	12-15
6799515-9	1982	These results suggest that the CoA-mediated, ATP-independent breakdown of phosphatidylcholine and transfer of arachidonic acid is catalyzed by the acyl-CoA:lysophosphatide acyltransferase operating in reverse.	Phosphatidylcholines	74-93	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	152-155
6807835-3	1982	Phospholipase A2 digestion of the intact erythrocytes resulted in a diminution of exclusively phosphatidylcholine (PC) from the membrane, and an approximately parallel loss of Rh antigen activity at 37 degrees to about 50% of the original.	Phosphatidylcholines	94-113	phospholipase A2 group IB	Homo sapiens	0-16
7087686-3	1982	In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was  labeled in the 2-position with [1-14C] oleic acid.	Phosphatidylcholines	123-142	LOC104974671	Bos taurus	50-66
7087686-3	1982	In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was  labeled in the 2-position with [1-14C] oleic acid.	Phosphatidylcholines	144-146	LOC104974671	Bos taurus	50-66
6275924-5	1982	For the phosphatidylcholine spin label there are effectively 55 +/- 5 lipids/200,000-dalton cytochrome oxidase, 58 +/- 4 mol lipid/265,000 dalton (Na+, K+)-ATPase, and 24 +/- 3 and 22 +/- 2 mol lipid/37,000 dalton rhodopsin for the bovine and frog preparations, respectively.	Phosphatidylcholines	8-27	rhodopsin	Bos taurus	214-223
6807835-3	1982	Phospholipase A2 digestion of the intact erythrocytes resulted in a diminution of exclusively phosphatidylcholine (PC) from the membrane, and an approximately parallel loss of Rh antigen activity at 37 degrees to about 50% of the original.	Phosphatidylcholines	115-117	phospholipase A2 group IB	Homo sapiens	0-16
6188759-1	1982	The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells.	Phosphatidylcholines	103-122	interferon alpha 1	Homo sapiens	20-36
6188759-1	1982	The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells.	Phosphatidylcholines	124-126	interferon alpha 1	Homo sapiens	20-36
6188759-2	1982	An inhibition of the synthesis of PC via this pathway was regularly observed with both alpha- (recombinant or natural) and beta-IFN.	Phosphatidylcholines	34-36	interferon alpha 1	Homo sapiens	128-131
6804944-3	1982	The isolated IgG-binding proteins specifically bound to IgG2a, but not to IgG2b, whereas the isolated phosphatidylcholine-binding proteins specifically bound to IgG2b but not to IgG2a.	Phosphatidylcholines	102-121	immunoglobulin heavy constant gamma 2B	Mus musculus	161-166
7070579-1	1982	The phospholipid composition and the in vitro incorporation of radioactive CDP-choline into phosphatidylcholine was studied in mitochondria and microsomal fraction obtained from liver and brain of 20 day old hyperthyroid or hypothyroid rats.	Phosphatidylcholines	92-111	cut-like homeobox 1	Rattus norvegicus	75-78
6804944-4	1982	Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine.	Phosphatidylcholines	0-19	phospholipase A2, group IB, pancreas	Mus musculus	57-73
6804944-4	1982	Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine.	Phosphatidylcholines	300-319	phospholipase A2, group IB, pancreas	Mus musculus	57-73
6804944-5	1982	The noted enzymatic activity was augmented 4-fold by preincubating phosphatidylcholine-binding proteins with heat-aggregated murine IgG2b but not with IgG2a.	Phosphatidylcholines	67-86	immunoglobulin heavy constant gamma 2B	Mus musculus	132-137
7299128-6	1981	FcR gamma is also induced on approximately 40% of M1- cells by incubating cells with cholesterol-phosphatidyl-choline liposomes with the concomitant increase of their membrane microviscosity.	Phosphatidylcholines	97-117	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	0-9
7146568-5	1982	There was also observed a marked increase in specific radioactivity of sphingomyelin, which could be due to a stimulation of CDP-choline: ceramide cholinephosphotransferase reaction with subsequent diminution of the rate of phosphatidylcholine synthesis via the CDP-amine pathway (involving cytidine diphosphocholine).	Phosphatidylcholines	224-243	cut-like homeobox 1	Rattus norvegicus	125-128
6275886-11	1981	The rate of phosphatidylcholine synthesis measured from incorporation of di[1-14C]palmitoyl glycerol equalled that observed with labeled CDP choline.	Phosphatidylcholines	12-31	cut-like homeobox 1	Rattus norvegicus	137-140
6273120-2	1981	During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and incorporation of [3H]glycerol and [14C]palmitate into phosphatidylcholine and phosphatidylethanolamine, two major phospholipids which are derived from phosphatidic acid, but are extrinsic to the inositide pathway.	Phosphatidylcholines	161-180	proopiomelanocortin	Homo sapiens	57-61
6273120-4	1981	Similar to previously reported effects on phosphatidic acid and inositide phospholipids, cycloheximide blocked the effects of ACTH and cAMP on phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylcholines	143-162	proopiomelanocortin	Homo sapiens	126-130
6803776-2	1981	Affinity chromatography-purified and non-purified rabbit immunoglobulin G (IgG) raised against human immunoglobulin M (IgM) or kappa chain was incorporated into carboxyfluorescein-containing small unilamellar liposomes composed of egg phosphatidylcholine, cholesterol and phosphatidic acid (molar proportions 7:7:1).	Phosphatidylcholines	235-254	immunoglobulin heavy variable V1-62	Mus musculus	75-78
6796129-2	1981	The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in  0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7).	Phosphatidylcholines	86-105	cytochrome c oxidase subunit 8A	Homo sapiens	22-26
6796129-2	1981	The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in  0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7).	Phosphatidylcholines	107-109	cytochrome c oxidase subunit 8A	Homo sapiens	22-26
6271752-3	1981	Following reconstitution into phosphatidylcholine vesicles, the channel regained 125I-ScTX binding and thermal stability of [3H]STX binding.	Phosphatidylcholines	30-49	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	128-131
7306536-1	1981	Previous studies have revealed that the replacement of the C-2 ester group in phosphatidylcholine by the carbamyloxy function renders the resulting lipids, without affecting the properties of the liposomes, resistant to hydrolysis by phospholipase A2 (Gupta, C.M.	Phosphatidylcholines	78-97	phospholipase A2 group IB	Homo sapiens	234-250
7311737-0	1981	Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase.	Phosphatidylcholines	25-44	phospholipase A2 group IB	Homo sapiens	48-64
7338519-2	1981	Liposomes composed of phosphatidylcholine and stearylamine were agglutinated with CRP.	Phosphatidylcholines	22-41	C-reactive protein	Homo sapiens	82-85
7338519-5	1981	Agglutination of liposomes caused by CRP was dependent on the fatty acid composition of phosphatidylcholine, cholesterol content and temperature.	Phosphatidylcholines	88-107	C-reactive protein	Homo sapiens	37-40
6121556-4	1981	By using this method, microvillus aminopeptidase was inserted almost quantitatively into either phosphatidylcholine vesicles or microvillus-lipid vesicles.	Phosphatidylcholines	96-115	alanyl aminopeptidase, membrane	Sus scrofa	34-48
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	37-56	Bardet-Biedl syndrome 9	Homo sapiens	29-32
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-6	1981	The order of sensitivity was C18 : 2 phosphatidylcholine greater than C18: I phosphatidylcholine greater than C18 : 0 phosphatidylcholine = C16 : 0 phosphatidylcholine.	Phosphatidylcholines	77-96	Bardet-Biedl syndrome 9	Homo sapiens	70-73
6895326-8	1981	The inclusion of 40 mol% cholesterol in C16 : 0 phosphatidylcholine and C18 : 0 phosphatidylcholine liposomes made these vesicles sensitive to streptolysin S. Egg phosphatidylcholine liposomes, which were unaffected at 0 degrees C and 4 degrees C became susceptible to the toxin at these temperatures when cholesterol was included.	Phosphatidylcholines	80-99	Bardet-Biedl syndrome 9	Homo sapiens	72-75
6895326-8	1981	The inclusion of 40 mol% cholesterol in C16 : 0 phosphatidylcholine and C18 : 0 phosphatidylcholine liposomes made these vesicles sensitive to streptolysin S. Egg phosphatidylcholine liposomes, which were unaffected at 0 degrees C and 4 degrees C became susceptible to the toxin at these temperatures when cholesterol was included.	Phosphatidylcholines	80-99	Bardet-Biedl syndrome 9	Homo sapiens	72-75
7295746-1	1981	In this study we have determined the effects of two commercial albumin preparations (Sigma and Pentex albumins) and two detergents (sodium deoxycholate and Triton X-100) on the activity of lipoprotein lipase purified from bovine milk against biosynthetically labeled triacylglycerol in very low density lipoprotein and biosynthetically labeled phosphatidylcholine in very low density and high density lipoproteins.	Phosphatidylcholines	344-363	lipoprotein lipase	Bos taurus	189-207
7309711-2	1981	Fatty acid omega- and (omega-1)-hydroxylation activity was reconstituted from the partially purified cytochrome P-450 and NADPH-cytochrome c reductase, with phosphatidylethanolamine or phosphatidylcholine.	Phosphatidylcholines	185-204	cytochrome P-450	Oryctolagus cuniculus	101-117
7314059-0	1981	Enhancement of thrombin-induced degradation of phosphatidylcholine in reserpinized rabbit platelets.	Phosphatidylcholines	47-66	prothrombin	Oryctolagus cuniculus	15-23
7314059-3	1981	TLC analysis revealed that the stimulation of the decrease in radioactivity of phospholipids was almost exclusively attributed to that of phosphatidylcholine (PC), and that thrombin induced a slight but significant increase in radioactivity of phosphatidylethanolamine (PE) in the reserpinized platelets.	Phosphatidylcholines	159-161	prothrombin	Oryctolagus cuniculus	173-181
7314059-4	1981	The results suggest that thrombin-induced degradation of PC is enhanced in the reserpinized platelets, and the overproduced fatty acids would be metabolized to the larger amount of oxygenated products which result in the activation of the platelets.	Phosphatidylcholines	57-59	prothrombin	Oryctolagus cuniculus	25-33
7314059-5	1981	Thrombin-induced mobilization of PC to PE in the reserpinized platelet phospholipids was also suggested.	Phosphatidylcholines	33-35	prothrombin	Oryctolagus cuniculus	0-8
6264965-11	1981	We propose that a principal pathway for degradation of phosphatidylcholine, particularly during brain ischemia, is by reversal of cholinephosphotransferase, followed by hydrolysis of diacylglycerols by the lipase.	Phosphatidylcholines	55-74	lipase G, endothelial type	Rattus norvegicus	206-212
7263710-10	1981	Phosphatidylcholine might reassociate as the membrane fluid bilayer, which in turn modulated the monoamine oxidase A activity.	Phosphatidylcholines	0-19	monoamine oxidase A	Homo sapiens	97-116
6167576-1	1981	The effect of cAMP analogues on phosphatidylcholine formation via the CDP-choline pathway was investigated in cultured monolayers of rat hepatocytes.	Phosphatidylcholines	32-51	cut-like homeobox 1	Rattus norvegicus	70-73
7264659-3	1981	In Trembler cells, cultivated in the presence of labelled acetate, the fatty acids were slightly altered; phosphatidylcholine was slightly reduced and phosphatidylethanolamine increased.	Phosphatidylcholines	106-125	peripheral myelin protein 22	Mus musculus	3-11
6269639-0	1981	Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth.	Phosphatidylcholines	99-118	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	34-37
6973491-0	1981	CoA-dependent cleavage of arachidonic acid from phosphatidylcholine and transfer to phosphatidylethanolamine in homogenates of murine thymocytes.	Phosphatidylcholines	48-67	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	0-3
6943585-8	1981	Peripheral blood mononuclear cells were also directly shown to display phospholipase A2-like activity, as measured by the decrease in radioactive arachidonate from prelabeled phospholipids, specifically phosphatidylcholine, in effector cells.	Phosphatidylcholines	203-222	phospholipase A2 group IB	Homo sapiens	71-87
7289798-6	1981	Phospholipase A2 action on phosphatidylcholine and phosphatidylethanolamine demonstrated enrichment of the c,c- and the c,t-18:2 products in the 2-position, whereas the 18:1 substrates were preferentially inserted into the 1-positions.	Phosphatidylcholines	27-46	phospholipase A2 group IB	Rattus norvegicus	0-16
7019229-5	1981	Cortisol (0.2 micrograms/ml) plus PRL (2.5 micrograms/ml), when added to the medium from the beginning of the culture period, caused a 2- to 3-fold increase in the rate of choline incorporation into phosphatidylcholine, as measured on the second, fourth, sixth, and eighth days of incubation, as well as an increase in the phosphatidylcholine content of the explants.	Phosphatidylcholines	199-218	prolactin	Homo sapiens	34-37
7019229-5	1981	Cortisol (0.2 micrograms/ml) plus PRL (2.5 micrograms/ml), when added to the medium from the beginning of the culture period, caused a 2- to 3-fold increase in the rate of choline incorporation into phosphatidylcholine, as measured on the second, fourth, sixth, and eighth days of incubation, as well as an increase in the phosphatidylcholine content of the explants.	Phosphatidylcholines	323-342	prolactin	Homo sapiens	34-37
7019229-9	1981	Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination.	Phosphatidylcholines	13-32	insulin	Homo sapiens	116-123
7019229-9	1981	Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination.	Phosphatidylcholines	13-32	prolactin	Homo sapiens	159-162
7019229-9	1981	Increases in phosphatidylcholine synthesis and lamellar body secretion also were observed in tissues incubated with insulin (2.5 micrograms/ml), cortisol, and PRL in combination or with insulin and cortisol in combination.	Phosphatidylcholines	13-32	insulin	Homo sapiens	186-193
6791934-3	1981	Incubation in vitro of VLDL with the lipase caused hydrolysis of VLDL-triglycerides (greater than 80%) and VLDL-phosphatidylcholine (greater than 30%).	Phosphatidylcholines	112-131	lipase G, endothelial type	Rattus norvegicus	37-43
6164508-1	1981	Hydrophobic compounds influenced the accuracy of the radioimmunoassay for myelin basic protein when lipids (stearic acid, phosphatidylcholine, cholesterol, cerebroside, sulfatide, or GM1 ganglioside) or proteolipids (white-matter proteolipid apoprotein, kidney proteolipid apoproteins, or heart proteolipid apoproteins) were added to a known amount of basic protein and the samples assayed.	Phosphatidylcholines	122-141	myelin basic protein	Homo sapiens	74-94
7217669-0	1981	Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement.	Phosphatidylcholines	50-69	C-reactive protein	Homo sapiens	15-33
7217669-2	1981	Binding of CRP to multilamellar liposomes or unilamellar vesicles of egg-phosphatidylcholine required the presence of lysophosphatide in the bilayer.	Phosphatidylcholines	73-92	C-reactive protein	Homo sapiens	11-14
7217669-5	1981	In addition, incorporation of galactocyl cerebroside in phosphatidylcholine:lysophosphatidylcholine liposomes enhanced the binding of CRP.	Phosphatidylcholines	56-75	C-reactive protein	Homo sapiens	134-137
7219528-3	1981	Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	192-211	phosphatidylethanolamine N-methyltransferase	Homo sapiens	107-151
6272753-11	1981	These results provide good evidence that the rate-limiting step for phosphatidylcholine biosynthesis in these cultured hepatocytes is the conversion of phosphocholine into CDP-choline.	Phosphatidylcholines	68-87	cut-like homeobox 1	Rattus norvegicus	172-175
7284359-4	1981	Differential scanning calorimetry experiments show a miscibility of alk(en)yl resorcinols with phosphatidylcholines.	Phosphatidylcholines	95-115	ALK receptor tyrosine kinase	Homo sapiens	68-71
6452452-10	1981	With vesicles containing a mixture of phosphatidylserine with phosphatidylcholine, synexin enhances aggregation in the presence of CA2+, without promoting fusion.	Phosphatidylcholines	62-81	annexin A7	Homo sapiens	83-90
7219528-3	1981	Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	192-211	phosphatidylethanolamine N-methyltransferase	Homo sapiens	153-157
7219528-3	1981	Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	213-215	phosphatidylethanolamine N-methyltransferase	Homo sapiens	107-151
7219528-3	1981	Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE).	Phosphatidylcholines	213-215	phosphatidylethanolamine N-methyltransferase	Homo sapiens	153-157
6257695-4	1981	Thermal transitions were detected in Arrhenius plots of 5"-nucleotidase after detergent solubilization, in the membranes which contained the three phospholipids, but not in the purified fraction which contained only sphingomyelin; transitions were also detected after reassociation of the purified enzyme with microsomal or plasma membrane lipids and phosphatidylcholine but not with phosphatidylethanolamine.	Phosphatidylcholines	351-370	5' nucleotidase, ecto	Rattus norvegicus	56-71
6257500-2	1981	CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcholine (PC).	Phosphatidylcholines	110-129	carboxyl ester lipase	Rattus norvegicus	0-5
6257500-2	1981	CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcholine (PC).	Phosphatidylcholines	131-133	carboxyl ester lipase	Rattus norvegicus	0-5
6257500-5	1981	Both acid and alkaline CEase activities were markedly enhanced by increasing the concentration of PC, but not by phospholipids.	Phosphatidylcholines	98-100	carboxyl ester lipase	Rattus norvegicus	23-28
6257500-8	1981	Increases in both acid and alkaline CEase activities were observed in adrenal homogenates prepared from hypophysectomized rats treated with an iv injection of ACTH when the molar ratio of cholesteryl oleate to PC used as a substrate vesicle was 1:0.2, but not when the ratio was 1:2.	Phosphatidylcholines	210-212	carboxyl ester lipase	Rattus norvegicus	36-41
7462211-4	1981	Decreases in phosphatidylcholine and also phosphatidylethanolamine occur within 20 s after stimulation of platelets by thrombin.	Phosphatidylcholines	13-32	coagulation factor II, thrombin	Homo sapiens	119-127
7462211-6	1981	The concomitant increases in lysophosphatidylcholine and decreases in phosphatidylcholine, as well as the decreases in phosphatidylethanolamine, can only be explained by the stimulation of phospholipase A2 activity in platelets by thrombin.	Phosphatidylcholines	33-52	phospholipase A2 group IB	Homo sapiens	189-205
6452902-5	1981	In parallel with the lipid binding studies, we have measured the sensitivity of the catalytic activity of the Ca2+ ATPase to the fatty acyl chain characteristics of the phosphatidylcholine membranes in which the enzyme was reconstituted.	Phosphatidylcholines	169-188	carbonic anhydrase 2	Oryctolagus cuniculus	110-121
6111345-1	1981	The activities of purified (Na+ + K+)-ATPase supported by a series of phosphatidylcholines with monounsaturated (cis-9) fatty acyl chains (di(n : 1) phosphatidylcholine) varying in length from n = 12 to n = 23 were determined by the lipid titration technique.	Phosphatidylcholines	70-90	dynein axonemal heavy chain 8	Homo sapiens	38-44
6779878-10	1981	Thrombin also decreased the synthesis of phosphatidylcholine when choline was used as the radiolabeled substrate.	Phosphatidylcholines	41-60	coagulation factor II, thrombin	Homo sapiens	0-8
7213783-2	1981	A novel class of phospholipase-resisting phosphatidylcholine analogs, in which the C-2 ester group or both C-1 and C-2 ester groups have been replaced by carbomyloxy functions (Formula--see text), have been synthesized.	Phosphatidylcholines	41-60	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	107-118
6257695-5	1981	Phosphatidylcholines containing specific fatty acids all affected the energy of activation of 5"-nucleotidase, and the detergent Sarkosyl, which has been shown to dissociate phospholipids from 5"-nucleotidase (Evans, W. H., and Gurd, J. W. (1973) Biochem.	Phosphatidylcholines	0-20	5' nucleotidase, ecto	Rattus norvegicus	94-109
6257695-5	1981	Phosphatidylcholines containing specific fatty acids all affected the energy of activation of 5"-nucleotidase, and the detergent Sarkosyl, which has been shown to dissociate phospholipids from 5"-nucleotidase (Evans, W. H., and Gurd, J. W. (1973) Biochem.	Phosphatidylcholines	0-20	5' nucleotidase, ecto	Rattus norvegicus	193-208
6257695-9	1981	It is concluded that in situ, 5"-nucleotidase interacts with both sphingomyelin and phosphatidylcholine; the first apparently influences the stability of the enzyme and the second, the energy of activation.	Phosphatidylcholines	84-103	5' nucleotidase, ecto	Rattus norvegicus	30-45
6263136-3	1981	Increased saturated phosphatidylcholine (SPC) synthesis without an increase in synthesis of total PC, and increased SPC/PC, was observed after exposure to Sigma prolactin.	Phosphatidylcholines	42-44	prolactin	Oryctolagus cuniculus	161-170
6174024-4	1981	A soluble ATPase extract having low phospholipid content was found to be activated by the phospholipid extracts of Vibrio el tor, phosphatidyl ethanolamine, and also by phosphatidyl choline which is not a constituent of the membrane preparation of Vibrio el tor strains.	Phosphatidylcholines	169-189	dynein axonemal heavy chain 8	Homo sapiens	10-16
6260171-0	1981	An in vitro ESR study of uncatalyzed rat liver protein-catalyzed spin-labeled phosphatidylcholine exchange.	Phosphatidylcholines	78-97	spindlin 1	Rattus norvegicus	65-69
6260171-1	1981	ESR spectrometry has been used to study fatty acid spin-labeled phosphatidylcholine exchange from single bilayer donor vesicles to various acceptor systems, such as intact or differently treated mitochondria, phospholipid multilamellar vesicles or single bilayer vesicles.	Phosphatidylcholines	64-83	spindlin 1	Homo sapiens	51-55
7213686-2	1981	13C spin-lattice relaxation times, nuclear Overhauser effects and spin-spin relaxation times have been measured for the C-4 carbon of cholesterol in phosphatidylcholine bilayers as a function of cholesterol content and temperature.	Phosphatidylcholines	149-168	complement C4A (Rodgers blood group)	Homo sapiens	120-123
7219664-4	1981	There was a tendency by the neuronal phospholipase A2 to release arachidonic acid faster than linolenic acid from both phosphatidylcholine and -ethanolamine, while arachidonic acid was removed less actively from phosphatidylethanolamine by the glial enzyme.	Phosphatidylcholines	119-138	phospholipase A2	Oryctolagus cuniculus	37-53
6894279-1	1981	Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7).	Phosphatidylcholines	0-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
6894279-1	1981	Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7).	Phosphatidylcholines	45-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
6894548-1	1980	Incubation of rat lung microsomes with CDP[Me-14C]choline resulted in formation of radioactive lysophosphatidylcholine and phosphatidylcholine.	Phosphatidylcholines	99-118	cut-like homeobox 1	Rattus norvegicus	39-42
6273927-2	1981	PC formed by transmethylation is further metabolized by phospholipase A2.	Phosphatidylcholines	0-2	phospholipase A2 group IB	Homo sapiens	56-72
7430120-9	1980	Deoxycholate treatment of the particulate fractions results in cleavage by phospholipase A2 of phosphatidylcholine and phosphatidylethanolamine but not of phosphatidylinositol.	Phosphatidylcholines	95-114	phospholipase A2	Equus caballus	75-91
6254970-11	1980	In the most highly purified LDL receptor preparation, which had been subjected to the sequential steps of solubilization, DEAE-cellulose chromatography, agarose gel filtration, and phosphatidylcholine/acetone precipitation, the receptor was estimated to constitute about 5% of the total protein.	Phosphatidylcholines	181-200	low density lipoprotein receptor	Bos taurus	28-40
7195282-0	1980	Pancreatic phospholipase A2 hydrolysis of phosphatidylcholines in various physicochemical states.	Phosphatidylcholines	42-62	phospholipase A2 group IB	Homo sapiens	11-27
7195282-7	1980	During an extended incubation, however, nearly all intralipid phosphatidylcholines and only half the bile phosphatidylcholines were hydrolyzed by pancreatic phospholipase A2.	Phosphatidylcholines	62-82	phospholipase A2 group IB	Homo sapiens	157-173
7430120-10	1980	The preferred substrates for platelet phospholipase A2 appear to be phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, while phosphatidylinositol seems to be degraded nearly exclusively by phospholipase C.	Phosphatidylcholines	94-113	phospholipase A2	Equus caballus	38-54
6774752-0	1980	Reassembly of human apoproteins A-I and A-II with unilamellar phosphatidylcholine-cholesterol liposomes.	Phosphatidylcholines	62-81	NLR family pyrin domain containing 3	Homo sapiens	40-44
6894263-0	1980	Correlation between serum lipoamide dehydrogenase activity and phosphatidylcholine therapy in Friedreich"s ataxia.	Phosphatidylcholines	63-82	dihydrolipoamide dehydrogenase	Homo sapiens	26-49
7214196-4	1980	It is concluded that LCAT possesses highly specific steric and positional requirements for its phosphatidylcholine substrates and that, like phospholipase A2, it has a significant activity with the 2-sn-phosphorylcholinedicacylglycerol.	Phosphatidylcholines	95-114	lecithin-cholesterol acyltransferase	Homo sapiens	21-25
7214196-4	1980	It is concluded that LCAT possesses highly specific steric and positional requirements for its phosphatidylcholine substrates and that, like phospholipase A2, it has a significant activity with the 2-sn-phosphorylcholinedicacylglycerol.	Phosphatidylcholines	95-114	phospholipase A2 group IB	Homo sapiens	141-157
6255856-6	1980	Thrombin induced aggregation results in release of arachidonic acid primarily from phosphatidyl choline and phosphatidyl inositol.	Phosphatidylcholines	83-103	coagulation factor II, thrombin	Homo sapiens	0-8
6778695-5	1980	It was shown that the apparent Km values of arylsulphatase and glycerol-3-phosphate dehydrogenase were higher in liposomes prepared with negatively charged phospholipids and lower in liposomes containing positively charged organic amines, as compared with th Km value of enzymes incorporated into liposomes prepared from phosphatidylcholine alone.	Phosphatidylcholines	321-340	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	63-97
7417445-2	1980	The permeability of phosphatidylcholine vesicles to Pr3+ is increased by several orders of magnitude over the self-diffusion rate and the kinetics indicate a transbilayer movement of inverted micelles [Pr(bile salt)4].	Phosphatidylcholines	20-39	proteinase 3	Homo sapiens	52-55
7407051-2	1980	The linear peptide hormones angiotensin II and [Asn1, Val5]angiotensin II are found to mediate the transport of Mn(II) ions across phosphatidylcholine bilayers.	Phosphatidylcholines	131-150	angiotensinogen	Homo sapiens	28-42
6251051-0	1980	Phosphatidylcholine vesicle reconstituted cytochrome P-450scc.	Phosphatidylcholines	0-19	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	42-61
6251051-2	1980	Cytochrome P-450scc from bovine adrenal cortex mitochondria was purified and reconstituted into phosphatidylcholine vesicles which varied in both cholesterol content and in the fatty acyl composition of the phospholipid.	Phosphatidylcholines	96-115	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	0-19
7236798-5	1980	Cytochrome P-450 incorporated into the artificial membranes of phosphatidyl choline and microsomal phospholipid has almost identical secondary structure as does the soluble one.	Phosphatidylcholines	63-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
6783529-7	1980	Both the inner and outer leaflets of the erythrocyte membrane were accessible to this rickettsial phospholipase A activity since both phosphatidylcholine and phosphatidylethanolamine were substrates in human erythrocytes.	Phosphatidylcholines	134-153	phospholipase A and acyltransferase 1	Homo sapiens	98-113
7407117-5	1980	50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate.	Phosphatidylcholines	10-29	rhodopsin	Bos taurus	60-69
7407117-5	1980	50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate.	Phosphatidylcholines	10-29	rhodopsin	Bos taurus	88-97
7407117-5	1980	50 mol of phosphatidylcholine were maximally bound to 1 mol rhodopsin when the purified rhodopsin was mixed with phosphatidylcholine in 0.5% cholate.	Phosphatidylcholines	113-132	rhodopsin	Bos taurus	60-69
6771275-7	1980	In addition, the turnover of phosphatidylcholine is more rapid in the cho1 mutant.	Phosphatidylcholines	29-48	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	70-74
7411590-0	1980	Action of phospholipase A2 on unmodified phosphatidylcholine bilayers: organizational defects are preferred sites of action.	Phosphatidylcholines	41-60	phospholipase A2 group IB	Homo sapiens	10-26
7407051-2	1980	The linear peptide hormones angiotensin II and [Asn1, Val5]angiotensin II are found to mediate the transport of Mn(II) ions across phosphatidylcholine bilayers.	Phosphatidylcholines	131-150	angiotensinogen	Homo sapiens	59-73
7411590-1	1980	The hydrolytic action of the bee venom phospholipase A2 on phosphatidylcholine bilayers is studied under a variety of conditions that introduce alterations in the packing, such as those induced by sonication, gel to liquid crystalline phase transition, and osmotic shock.	Phosphatidylcholines	59-78	phospholipase A2 group IB	Homo sapiens	39-55
7364757-5	1980	On the other hand, SPF was shown to bind tightly to vesicles of anionic phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, and phosphatidic acid) but not to vesicles of phosphatidylcholine or phosphatidylethanolamine.	Phosphatidylcholines	197-216	SEC14 like lipid binding 2	Homo sapiens	19-22
6158688-0	1980	Transmembrane orientation of lipophilin in phosphatidylcholine vesicles.	Phosphatidylcholines	43-62	proteolipid protein 1	Homo sapiens	29-39
6158688-1	1980	Lipophilin, a hydrophobic myelin protein, was incorporated into phosphatidylcholine vesicles by dialysis from 2-chloroethanol which has been shown to produce single-layered lipid-protein vesicles.	Phosphatidylcholines	64-83	proteolipid protein 1	Homo sapiens	0-10
7397160-1	1980	The kinetics of Ca2+-induced fusion of phosphatidylcholine-phosphatidic acid vesicles has been studied using the dependence of proton nuclear magnetic resonance linewidths on vesicle size.	Phosphatidylcholines	39-58	carbonic anhydrase 2	Homo sapiens	16-19
7190145-0	1980	C-Reactive protein induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine.	Phosphatidylcholines	102-121	C-reactive protein	Homo sapiens	0-18
7190145-1	1980	CRP-induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine was studied by a newly devised quantitative method.	Phosphatidylcholines	87-106	C-reactive protein	Homo sapiens	0-3
7190145-2	1980	CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP.	Phosphatidylcholines	69-88	C-reactive protein	Homo sapiens	0-3
7190145-2	1980	CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP.	Phosphatidylcholines	207-226	C-reactive protein	Homo sapiens	0-3
7190145-4	1980	Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions.	Phosphatidylcholines	9-28	C-reactive protein	Homo sapiens	134-137
7190145-4	1980	Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions.	Phosphatidylcholines	303-322	C-reactive protein	Homo sapiens	134-137
7378381-0	1980	Mechanism of exchange of cytochrome b5 between phosphatidylcholine vesicles.	Phosphatidylcholines	47-66	cytochrome b5 type A	Homo sapiens	25-38
6244061-3	1980	Axonal transport of 1,2-diacyl-glycerol:CDP-choline choline phosphotransferase (EC 2.7.8.2), required for de novo phosphatidylcholine synthesis, was not apparent in these studies.	Phosphatidylcholines	114-133	cut-like homeobox 1	Rattus norvegicus	40-43
6245576-2	1980	Preliminary results suggest that phosphatidylcholine synthesis via the phosphatidic acid phosphohydrolase pathway in addition to phosphatidylglycerol may be stimulated by the presence of prolactin.	Phosphatidylcholines	33-52	prolactin	Homo sapiens	187-196
7370284-14	1980	The binding of colipase to Intralipid, an emulsion of a long-chain triacylglycerol stabilized with phosphatidylcholine and glycerol, was more complex with indications of several different binding sites with different affinity.	Phosphatidylcholines	99-118	colipase	Homo sapiens	15-23
7354136-3	1980	Lysine and aspartic acid appeared to modify the cholinephosphotransferase reaction in which cytidine 5"-diphosphocholine (CDP-choline) and 1,2-diacylglycerol react to form phosphatidylcholine, the major phospholipid of renal membranes.	Phosphatidylcholines	172-191	cut-like homeobox 1	Rattus norvegicus	122-125
6243290-1	1980	Poliovirus increases phosphatidylcholine biosynthesis in HeLa cells by stimulation of the reaction catalyzed by CTP:phosphocholine cytidylyltransferase (Vance, D.E., Trip, E.M., and Paddon, H.B.	Phosphatidylcholines	21-40	solute carrier family 25 member 1	Homo sapiens	112-115
6243483-16	1980	The differences in the results obtained with the various phosphatidylcholines above their transition temperature suggest that the solubility of rhodopsin in bilayers depends not only on the fluidity of the lipids, but also, to some extent, on the phospholipid chain length.	Phosphatidylcholines	57-77	rhodopsin	Bos taurus	144-153
6243999-3	1980	Spin labels derived from five carboxylic acids of different lengths were synthesized and incorporated in varying amounts into multilamellar and unilamellar vesicles made up of four different phosphatidylcholines.	Phosphatidylcholines	191-211	spindlin 1	Homo sapiens	0-4
6243290-14	1980	Moreover, it appears that the concentration of CTP in the cytoplasm can determine the rate of phosphatidylcholine biosynthesis in HeLa cells.	Phosphatidylcholines	94-113	solute carrier family 25 member 1	Homo sapiens	47-50
7358621-0	1980	Topological studies of the membrane-binding segment of cytochrome b5 embedded in phosphatidylcholine vesicles.	Phosphatidylcholines	81-100	cytochrome b5 type A	Homo sapiens	55-68
6768948-0	1980	Interaction of human plasma high density lipoprotein HDL2 with synthetic saturated phosphatidylcholines.	Phosphatidylcholines	83-103	junctophilin 3	Homo sapiens	53-57
6768948-4	1980	Redistributed apoA-I occurred as lipid-free apoA-I and/or as complexes of apoA-I and/or as compelxes of apoA-I with phosphatidylcholine.	Phosphatidylcholines	116-135	apolipoprotein A1	Homo sapiens	14-20
6775511-3	1980	Additional components are NADPH-cytochrome P-450 reductase, which binds to the cytochrome to form a tight 1:1 complex, phosphatidylcholine, and cytochrome b5, the role of which is still not clear.	Phosphatidylcholines	119-138	cytochrome p450 oxidoreductase	Homo sapiens	26-58
7370002-8	1980	Liver mitochondria isolated from normal animals incubated in vitro with CDP-choline, in the presence of different concentrations of L-thyroxine, showed also a marked decrease in the incorporation of label into phosphatidylcholine, whereas no significant changes were found in the total homogenate and in the microsomal fraction compared with control experiments.	Phosphatidylcholines	210-229	cut-like homeobox 1	Rattus norvegicus	72-75
6156917-3	1980	A simultaneous striking increase in prostaglandin D2 synthesis by the A23187-treated mast cells suggests that the degradation of phosphatidylcholine is associated with the activation of phospholipase A2.	Phosphatidylcholines	129-148	phospholipase A2 group IB	Rattus norvegicus	186-202
7358621-1	1980	Carboxypeptidase Y (CPY) digestion of cytochrome b5 incorporated into single-walled liposomes of egg phosphatidylcholine (PC) resulted in the release of 25 amino acid residues form each molecule of the cytochrome and concomitant detachment of the cytochrome from the vesicles.	Phosphatidylcholines	101-120	cytochrome b5 type A	Homo sapiens	38-51
7358621-1	1980	Carboxypeptidase Y (CPY) digestion of cytochrome b5 incorporated into single-walled liposomes of egg phosphatidylcholine (PC) resulted in the release of 25 amino acid residues form each molecule of the cytochrome and concomitant detachment of the cytochrome from the vesicles.	Phosphatidylcholines	122-124	cytochrome b5 type A	Homo sapiens	38-51
500697-2	1979	Cytochrome P-450scc can be reconstituted into a phospholipid bilayer in the absence of added detergent by incubation of purified hemoprotein with preformed phosphatidylcholine vesicles.	Phosphatidylcholines	156-175	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-19
7243826-1	1980	Enzymatic methylation of phosphotidylethanolamine (PE) to form phosphatidylcholine (PC) is associated with translocation of the lipid from the inner cell membrane (PE) to the outer membrane (PC), a concomitant decrease in membrane viscosity, and in some cases, activation of phospholipase A and release of arachidonic acid.	Phosphatidylcholines	63-82	phospholipase A and acyltransferase 1	Rattus norvegicus	275-290
7243826-1	1980	Enzymatic methylation of phosphotidylethanolamine (PE) to form phosphatidylcholine (PC) is associated with translocation of the lipid from the inner cell membrane (PE) to the outer membrane (PC), a concomitant decrease in membrane viscosity, and in some cases, activation of phospholipase A and release of arachidonic acid.	Phosphatidylcholines	84-86	phospholipase A and acyltransferase 1	Rattus norvegicus	275-290
293667-0	1979	Lateral mobility of an amphipathic apolipoprotein, ApoC-III, bound to phosphatidylcholine bilayers with and without cholesterol.	Phosphatidylcholines	70-89	apolipoprotein C3	Homo sapiens	51-59
387773-8	1979	We conclude that bradykinin, thrombin, and serum activate phospholipases that specifically hydrolyze arachidonyl and eicosatrienoyl phosphatidylinositol and phosphatidylcholine, whereas A23187 is less specific activator of phospholipases.	Phosphatidylcholines	157-176	coagulation factor II	Mus musculus	29-37
231173-0	1979	Ethanolamine kinase activity and compositions of diacylglycerols, phosphatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats.	Phosphatidylcholines	66-86	choline kinase beta	Rattus norvegicus	0-19
43142-6	1979	Furthermore hydrolysis of phosphatidylcholine by the skin phospholipase A was also enhanced by low concentrations of prostaglandin E2 and prostaglandin F2 alpha.	Phosphatidylcholines	26-45	phospholipase A and acyltransferase 1	Homo sapiens	58-73
293667-1	1979	The technique of fluorescence recovery after photobleaching was used to investigate the lateral mobility of a fluorescein-labeled amphipathic apolipoprotein, ApoC-III, bound to multibilayers prepared from dipalmitoyl phosphatidylcholine, egg phosphatidylcholine, and a 1:1 (molar ratio) mixture of egg phosphatidylcholine and cholesterol.	Phosphatidylcholines	217-236	apolipoprotein C3	Homo sapiens	158-166
293667-3	1979	In egg phosphatidylcholine bilayers, D is about 3 x 10(-8) cm(2) sec(-1) at 20 degrees C and the Arrhenius activation energy for diffusion is 8.1 kcal mol(-1) between 15 and 35 degrees C in this system.	Phosphatidylcholines	7-26	secretory blood group 1, pseudogene	Homo sapiens	65-71
293667-4	1979	In bilayers prepared from an equimolar mixture of egg phosphatidylcholine and cholesterol D at 20 degrees C is about 1.4 x 10(-9) cm(2) sec(-1) and the Arrhenius activation energy for the diffusion of the protein in this system between 15 and 35 degrees C is 15.1 kcal mol(-1).	Phosphatidylcholines	54-73	secretory blood group 1, pseudogene	Homo sapiens	136-142
293667-1	1979	The technique of fluorescence recovery after photobleaching was used to investigate the lateral mobility of a fluorescein-labeled amphipathic apolipoprotein, ApoC-III, bound to multibilayers prepared from dipalmitoyl phosphatidylcholine, egg phosphatidylcholine, and a 1:1 (molar ratio) mixture of egg phosphatidylcholine and cholesterol.	Phosphatidylcholines	242-261	apolipoprotein C3	Homo sapiens	158-166
227688-5	1979	The results are explained by assuming that the transport unit and the catalytic moiety of the glucose-6-phosphatase system have different lipid requirements, the activity of the former protein depending mainly on phosphatidylethanolamine and phosphatidylserine and that of the catalytic protein depending on phosphatidylcholine.	Phosphatidylcholines	308-327	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	94-115
471064-0	1979	Interaction of C-reactive protein with artificial phosphatidylcholine bilayers.	Phosphatidylcholines	50-69	C-reactive protein	Homo sapiens	15-33
471064-3	1979	CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM).	Phosphatidylcholines	133-152	C-reactive protein	Homo sapiens	0-3
391228-0	1979	Asymmetry requirement for Ca2+ induced fusion of phosphatidylcholine-phosphatidic acid vesicles.	Phosphatidylcholines	49-68	carbonic anhydrase 2	Homo sapiens	26-29
227688-7	1979	THis suggests that the diminished activity of glucose-6-phosphatase in hepatomas may be partly due to a low level of phosphatidylcholine.	Phosphatidylcholines	117-136	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	46-67
573139-1	1979	The addition of Ca2+ to small unilamellar vesicles of an equimolar mixture of egg phosphatidylcholine and cardiolipin induces fusion of these vesicles in association with the appearance of lipidic particles on the fusion sites.	Phosphatidylcholines	82-101	carbonic anhydrase 2	Homo sapiens	16-19
226973-1	1979	Human beta-endorphin adopts a partial helical conformation in aqueous solutions of cerebroside sulfate, ganglioside GM1, phosphatidylserine, and phosphatidic acid, but not of cerebroside and phosphatidylcholine, as evidenced by circular dichroic spectra.	Phosphatidylcholines	191-210	proopiomelanocortin	Homo sapiens	6-20
447630-0	1979	Mechanism of cytochrome b5 binding to phosphatidylcholine vesicles.	Phosphatidylcholines	38-57	cytochrome b5 type A	Homo sapiens	13-26
582173-1	1979	The activity of phospholipase A2 from cobra venom toward phospholipid in single-walled, sonicated vesicles was analyzed, particularly with respect to its activity toward the saturated phosphatidylcholines in the gel and liquid crystalline states.	Phosphatidylcholines	184-204	phospholipase A2 group IB	Homo sapiens	16-32
476097-2	1979	The C15-, C17- and C19-diacyl species show gel to liquid-crystalline transitions and pretransitions like those of the even-chain phosphatidylcholines.	Phosphatidylcholines	129-149	placenta associated 8	Homo sapiens	4-7
476097-2	1979	The C15-, C17- and C19-diacyl species show gel to liquid-crystalline transitions and pretransitions like those of the even-chain phosphatidylcholines.	Phosphatidylcholines	129-149	cytokine like 1	Homo sapiens	10-13
113393-7	1979	The partially purified cytochrome P-450 was active in fatty acid hydroxylation in combination with intestinal NADPH-cytochrome c reductase and phosphatidylcholine.	Phosphatidylcholines	143-162	cytochrome P-450	Oryctolagus cuniculus	23-39
223955-1	1979	Lipoprotein particles reconstituted from the apolipoprotein AII (apo AII) component of human serum high density lipoprotein, phosphatidylcholine and lysophosphatidylcholine were covalently linked to the imidoester groups of a polystyrene residue.	Phosphatidylcholines	125-144	apolipoprotein A2	Homo sapiens	45-63
454594-6	1979	From the initial velocity rate, the time required for the phosphatidylcholine pool to double was about 12 h. Agarose-linked phospholipase A2 was used to measure the relative composition of choline- and dimethylethanolamine-phosphoglycerides in the outer surface of vesicles prepared from cells with different degrees of polar head group substitution.	Phosphatidylcholines	58-77	phospholipase A2 group IB	Homo sapiens	124-140
223955-1	1979	Lipoprotein particles reconstituted from the apolipoprotein AII (apo AII) component of human serum high density lipoprotein, phosphatidylcholine and lysophosphatidylcholine were covalently linked to the imidoester groups of a polystyrene residue.	Phosphatidylcholines	125-144	apolipoprotein A2	Homo sapiens	65-72
223956-1	1979	Apolipoprotein AII isolated from human serum high density lipoproteins was recombined with phosphatidylcholine to yield homogeneous particles of 80-120 A diameter.	Phosphatidylcholines	91-110	apolipoprotein A2	Homo sapiens	0-18
456381-4	1979	The transition temperature from gel-crystalline to liquid-crystalline phase in 24 degrees C for the dimyristoyl-phosphatidylcholine vesicles and is shifted to around 30 degrees C in the complexes between phosphatidylcholine and apoA-I, apoA-II, apoC-I, apoC-III proteins while the cooperativity of the transition is decreased.	Phosphatidylcholines	112-131	apolipoprotein A1	Homo sapiens	228-234
459721-4	1979	Three times more elaidic than oleic acid (OI) accumulated in the 1-acyl position of phosphatidylcholine, as determined by hydrolysis with phospholipase A2.	Phosphatidylcholines	84-103	phospholipase A2 group IB	Homo sapiens	138-154
582621-2	1979	When 14C-glucose was used as substrate, incorporation into both phosphatidylcholine and saturated phosphatidylcholine was reduced by insulin.	Phosphatidylcholines	64-83	insulin	Oryctolagus cuniculus	133-140
456381-5	1979	At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine .	Phosphatidylcholines	97-116	apolipoprotein A1	Homo sapiens	122-128
456381-5	1979	At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine .	Phosphatidylcholines	97-116	apolipoprotein A2	Homo sapiens	130-137
456381-5	1979	At temperatures below the transition of the phospholipid, the microviscosity of the complexes of phosphatidylcholine with apoA-I, apoA-II and apoC-I proteins is lower than that of the phosphatidylcholine, while the opposite effect is observed above 30 degrees C. The phosphatidylcholine .	Phosphatidylcholines	97-116	apolipoprotein C1	Homo sapiens	142-148
221897-2	1979	When EL4 membranes are incubated with sonicated lipid vesicles containing spin-labeled phosphatidylcholine and then purified, they exhibit paramagnetic resonance spectra characteristic of spin labels dilutely dispersed in the lipid bilayer.	Phosphatidylcholines	87-106	epilepsy 4	Mus musculus	5-8
465128-10	1979	Compared with NaOH-purified elastin, the other elastin samples were characterized by an increased phosphatidyl--choline content, while they all contained an almost equal amount of phosphatidylethanolamine.	Phosphatidylcholines	98-119	elastin	Homo sapiens	47-54
38406-9	1979	The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline.	Phosphatidylcholines	256-276	tachykinin precursor 1	Homo sapiens	60-62
38406-9	1979	The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline.	Phosphatidylcholines	256-276	tachykinin precursor 1	Homo sapiens	105-107
38406-9	1979	The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline.	Phosphatidylcholines	256-276	tachykinin precursor 1	Homo sapiens	105-107
103585-0	1979	Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles.	Phosphatidylcholines	93-112	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	20-52
420827-3	1979	One enzyme with phospholipase A2 specificity was found to be responsible for both phosphatidyl-ethanolamine and phosphatidylcholine degradation.	Phosphatidylcholines	112-131	phospholipase A2	Ovis aries	16-32
284415-2	1979	Towards this end, we have constructed unilamellar phosphatidylcholine liposomes containing H-2 and Ia antigens.	Phosphatidylcholines	50-69	relaxin 2	Homo sapiens	91-101
35234-0	1979	Phospholipase A2 in rat-lung microsomes: substrate specificity towards endogenous phosphatidylcholines.	Phosphatidylcholines	82-102	phospholipase A2 group IB	Rattus norvegicus	0-16
758952-0	1979	Inhibition of the binding of cytochrome b5 to phosphatidylcholine vesicles by cholesterol.	Phosphatidylcholines	46-65	cytochrome b5 type A	Homo sapiens	29-42
758952-1	1979	The binding of cytochrome b5 to single-walled liposomes of egg phosphatidylcholine was inhibited by the presence of cholesterol in the lipid bilayer under conditions where a limited amount of liposomes was incubated with the cytochrome.	Phosphatidylcholines	63-82	cytochrome b5 type A	Homo sapiens	15-28
103585-0	1979	Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles.	Phosphatidylcholines	93-112	cytochrome P-450	Oryctolagus cuniculus	26-42
103585-6	1979	The rate constant of the slow phase as well as the fraction of cytochrome P-450 reducible in the slow phase, on the other hand, remains essentially constant even upon alteration in the ratio of the reductase to the cytochrome or in that of the two proteins to phosphatidylcholine.	Phosphatidylcholines	260-279	cytochrome P-450	Oryctolagus cuniculus	63-79
486580-0	1979	[Influence of phosphatidylcholine/cholesterol molar ratios in liposomes on cholesterol reactivity with cholesterol:oxygen oxidoreductase].	Phosphatidylcholines	14-33	thioredoxin reductase 1	Homo sapiens	122-137
583227-7	1979	It was concluded that the observed LPL and TGLH activation may account for the beneficial therapeutic effects of highly unsaturated phosphatidylcholine (EPL) in human hyperglyceridemias.	Phosphatidylcholines	132-151	lipoprotein lipase	Homo sapiens	35-38
42250-3	1979	Phosphatidylcholine is required in the reconstituted enzyme system for rapid electron transfer from NADPH to P-450 LM, catalyzed by NADPH-cytochrome P-450 reductase, as well as for maximal hydroxylation activity with either molecular oxygen or a peroxy compound serving as oxygen donor to the substrate.	Phosphatidylcholines	0-19	cytochrome p450 oxidoreductase	Homo sapiens	132-164
216396-1	1978	The hydrolytic activity of a lipoprotein lipase from bovine milk against triacylglycerol and phosphatidylcholine of rat plasma very low density lipoprotein was determined and compared to that against phosphatidylcholine of high density lipoprotein.	Phosphatidylcholines	93-112	lipoprotein lipase	Bos taurus	29-47
32674-2	1978	Platelets, as in platelet rich plasma when labelled with arachidonic acid, washed and treated with thrombin, released radioactivity mainly from phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	144-163	coagulation factor II, thrombin	Homo sapiens	99-107
27520426-0	1978	Rapid enzyme-induced hydrolysis of microgram amounts of phosphatidylcholine on phospholipase A2/celite columns.	Phosphatidylcholines	56-75	phospholipase A2 group IB	Homo sapiens	79-95
739004-1	1978	Rabbit cytochrome b5 was incorporated into single-walled phosphatidylcholine liposomes, and the cytochrome b5-liposome complex thus formed was digested with trypsin.	Phosphatidylcholines	57-76	cytochrome b5	Oryctolagus cuniculus	7-20
658423-0	1978	Reconstitution of acetylcholinesterase activity from electroplax membrane fragments into phosphatidylcholine vesicles.	Phosphatidylcholines	89-108	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
214141-2	1978	Thrombin-induced release of arachidonic acid from human platelet phosphatidylcholine is found to be more than 90% impaired by incubation of platelets with 1 mM dibutyryl cyclic adenosine monophosphate (Bt2 cyclic AMP) or with 0.6 mM 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate (TMB-8), an intracellular calcium antagonist.	Phosphatidylcholines	65-84	coagulation factor II, thrombin	Homo sapiens	0-8
689034-2	1978	1-O-Alkyl-2-acyl-3-acetyl-glycerols and 1,2-diacyl-3-acetylglycerols were prepared from the ethanolamine and choline phosphoglycerides and fractionated by AgNO3-impregnated thin-layer chromatography into seven molecular species.	Phosphatidylcholines	109-134	O-acyltransferase like	Mus musculus	12-18
307491-15	1978	In infants with RDS, PC is low and PG absent.	Phosphatidylcholines	21-23	peripherin 2	Homo sapiens	16-19
677904-0	1978	Effect of the state of phosphatidylcholine on the rate of its hydrolysis by phospholipase A2 (bee venom).	Phosphatidylcholines	23-42	phospholipase A2 group IB	Homo sapiens	76-92
565217-2	1978	We examined the action of porcine pancreatic and bee-venom phospholipase A2 towards bilayers of phosphatidylcholine as a function of several physical characteristics of the lipid-water interface.	Phosphatidylcholines	96-115	phospholipase A2 group IB	Homo sapiens	59-75
638181-8	1978	Colipase alone exhibited strong binding to phosphatidylcholine and fatty acid mixed bile salt micelles when applied together in a sample on columns eluted with pure bile salt micelles, lipase did not.	Phosphatidylcholines	43-62	colipase	Homo sapiens	0-8
207309-0	1978	Kinetics of lipid--protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines.	Phosphatidylcholines	124-144	apolipoprotein A1	Homo sapiens	56-74
565217-17	1978	Vesicles composed of egg phosphatidylcholine can be degraded by pancreatic phospholipase A2 at 37 degrees C, provided that the substrate bilayer is strongly curved.	Phosphatidylcholines	25-44	phospholipase A2 group IB	Homo sapiens	75-91
629969-10	1978	Treatment of co-sonicated vesicles of phosphatidylcholine and lysophosphatidylcholine containing glycophorin with the enzyme lysophospholipase results in a complete degradation of the lyso-compound.	Phosphatidylcholines	38-57	phospholipase B1	Homo sapiens	125-142
147706-13	1978	Hydrolysis of 95% of the phosphatidylcholine and 60--70% of the spingomyelin and phosphatidylethanolamine by another phospholipase C (Clostridium welchii) lowers the (Na+ + K+)-ATPase activity by about 20%.	Phosphatidylcholines	25-44	LOC100009319	Oryctolagus cuniculus	117-132
204348-1	1978	The nature of the interaction between Sendai virus and Sil mutant cells was examined by measuring a change in ESR spectrum of spin-labeled phosphatidylcholine molecules on the viral envelope.	Phosphatidylcholines	139-158	STIL centriolar assembly protein	Homo sapiens	55-58
208359-4	1978	Incubation of microsomes with labeled alkylacylglycerols and CDP-choline, in the initial absence of CDP-ethanolamine, produced labeled ethanolamine glycerophospholipids as well as labeled choline glycerophospholipids.	Phosphatidylcholines	188-216	cut-like homeobox 1	Rattus norvegicus	61-64
656483-3	1978	When such microsomes were incubated with phosphatidylcholine in the presence of lipid exchange proteins the lysophosphatidylcholine was partly replaced by phosphatidylcholine and the inactive cytochrome P-450 was reactivated.	Phosphatidylcholines	41-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	192-208
656483-3	1978	When such microsomes were incubated with phosphatidylcholine in the presence of lipid exchange proteins the lysophosphatidylcholine was partly replaced by phosphatidylcholine and the inactive cytochrome P-450 was reactivated.	Phosphatidylcholines	112-131	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	192-208
200275-0	1977	Hydrolysis of phosphatidylcholine by phospholipase A2 does not cause dissociation of apolipoprotein C from rat plasma very low density lipoprotein.	Phosphatidylcholines	14-33	phospholipase A2 group IB	Rattus norvegicus	37-53
655003-1	1978	Thrombin, within seconds after its addition, stimulated the release of 1-14C-20:4n-6 from the platelet phospholipids, phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	118-137	coagulation factor II, thrombin	Homo sapiens	0-8
623825-2	1978	The resistance of BLM formed from phosphatidylcholine, tiophosphatidylcholine, threealkylphosphate and threealkyltiophosphate was 10(7)--10(8) Ohm.cm2.	Phosphatidylcholines	34-53	BLM RecQ like helicase	Homo sapiens	18-21
746344-0	1978	Phosphatidylcholine substrate specificity of lecithin:cholesterol acyltransferase.	Phosphatidylcholines	0-19	lecithin-cholesterol acyltransferase	Homo sapiens	45-81
746344-4	1978	It was found that the fatty acid in the 1-position of phosphatidylcholine significantly influences cholesteryl ester formation, both by its direct involvement in the LCAT reaction and its contribution to the physico-chemical properties of phosphatidylcholine.	Phosphatidylcholines	54-73	lecithin-cholesterol acyltransferase	Homo sapiens	166-170
271994-9	1977	We conclude that (i) CRP can sensitize appropriate liposomes for complement-dependent damage via the primary complement pathway starting at the level of C1q; (ii) of those studied, liposomes that are most susceptible to membrane damage contain phosphatidylcholine, have a positive charge, and contain a ceramide glycolipid; and (iii) such liposomes also are sensitive, although to a much lesser degree, to complement-dependent lysis initiated in the absence of CRP and involving consumption of terminal in excess of early acting complement components.	Phosphatidylcholines	244-263	C-reactive protein	Homo sapiens	21-24
717398-7	1978	The uptake of free 14 C-arachidonic acid by the platelets was greatly diminished, as was its thrombin-induced liberation from phosphatidyl-choline and phosphatidyl inositol.	Phosphatidylcholines	126-146	coagulation factor II, thrombin	Homo sapiens	93-101
271947-0	1977	Light-regulated permeability of rhodopsin:egg phosphatidylcholine recombinant membranes.	Phosphatidylcholines	46-65	rhodopsin	Homo sapiens	32-41
271947-1	1977	Purified rhodopsin was incorporated into phospholipid bilayers of egg phosphatidylcholine to give recombinant membrane vesicles, which were examined by proton and phosphorus nuclear magnetic resonance spectroscopy.	Phosphatidylcholines	70-89	rhodopsin	Homo sapiens	9-18
598786-1	1977	The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens.	Phosphatidylcholines	74-93	arginine vasopressin	Rattus norvegicus	97-100
20951-1	1977	Myelin basic protein associates with bilayer vesicles of pure egg phosphatidylcholine, L-alpha-dimyristoyl phosphatidylcholine and DL-alpha-dipalmitoyl phosphatidylcholine.	Phosphatidylcholines	66-85	myelin basic protein	Homo sapiens	0-20
598786-1	1977	The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens.	Phosphatidylcholines	74-93	arginine vasopressin	Rattus norvegicus	228-231
873919-1	1977	Detergent-extracted cytochrome b5, which binds readily to phosphatidylcholine vesicles, has been shown to exchange between vesicles by the following experiments.	Phosphatidylcholines	58-77	cytochrome b5 type A	Homo sapiens	20-33
197573-2	1977	The existence of marked differences in the degradation rate for each phospholipid suggests a relationship between the alteration of phosphatidylcholine containing one saturated and one unsaturated fatty acid and the decrease in activity of glucose-6-phosphatase; the inactivation of this enzyme was unrelated to the alteration of other phospholipids.	Phosphatidylcholines	132-151	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	240-261
195609-0	1977	NMR and ESR studies of the interactions of cytochrome c with mixed cardiolipin-phosphatidylcholine vesicles.	Phosphatidylcholines	79-98	cytochrome c, somatic	Homo sapiens	43-55
199582-1	1977	Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate.	Phosphatidylcholines	119-138	lecithin-cholesterol acyltransferase	Homo sapiens	0-37
199582-1	1977	Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate.	Phosphatidylcholines	119-138	lecithin-cholesterol acyltransferase	Homo sapiens	39-43
199582-1	1977	Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate.	Phosphatidylcholines	119-138	apolipoprotein A1	Homo sapiens	74-92
199582-1	1977	Lecithin: cholesterol acyltransferase (LCAT) was more highly activated by apolipoprotein A-I (apoA-I) with dimyristoyl phosphatidylcholine (DMPC) than with dilinoleoyl phosphatidylcholine (DLPC) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate.	Phosphatidylcholines	119-138	apolipoprotein A1	Homo sapiens	94-100
199582-4	1977	On the other hand, all of these phosphatidylcholines acted as substrates of LCAT when they were incorporated into HDL coupled to Sepharose.	Phosphatidylcholines	32-52	lecithin-cholesterol acyltransferase	Homo sapiens	76-80
142518-5	1977	Insulin treatment of normal animals 30 or 15 min prior to perfusion resulted in an approximate doubling of the incorporation of glucose into the phosphatidylcholine and phosphatidylglycerol isolated from the surfactant and residual fractions of the lung.	Phosphatidylcholines	145-164	insulin	Homo sapiens	0-7
196853-2	1977	The ethanols were administered to female bile fistula rats for 10 h. The hydrogen at C-2 in the glycerol moiety of newly formed phosphatidylcholine molecules in bile, liver and plasma was derived to 22-25% from the 1-pro-R position and to 5-6% from the 1-pro-S position in the ethanol.	Phosphatidylcholines	128-147	complement C2	Rattus norvegicus	85-88
406914-3	1977	Bovine serum albumin increased the hemolysis of human erythrocytes induced by dilauroylglycerophosphocholine or didecanoylglycerophosphocholine: it shortened the lag time of lysis and reduced the amount of phosphatidylcholine required for lysis.	Phosphatidylcholines	206-225	albumin	Homo sapiens	13-20
874074-3	1977	Human platelets have a mechanism for incorporating arachidonic acid from plasma into their phospholipids and, in response to thrombin, they reveal mechanisms for hydrolyzing this arachidonic acid from platelet phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	210-229	coagulation factor II, thrombin	Homo sapiens	125-133
557336-3	1977	Changes in the absorption spectra of glycerol-water mixtures of rhodopsin-egg phosphatidylcholine and rhodopsin-asolectin recombinants were monitored after the sample was cooled to -196 degrees C, presented with light of wavelength greater than 440 nm, and then warmed gradually to room temperature.	Phosphatidylcholines	78-97	rhodopsin	Homo sapiens	64-73
196860-1	1977	The action of lecithin:cholesterol acyltransferase (LCAT) was studied on an abnormal lipoprotein (LP-X) rich in phosphatidylcholine and cholesterol from the plasma of patients with obstructive liver disease.	Phosphatidylcholines	112-131	lecithin-cholesterol acyltransferase	Homo sapiens	14-50
196860-1	1977	The action of lecithin:cholesterol acyltransferase (LCAT) was studied on an abnormal lipoprotein (LP-X) rich in phosphatidylcholine and cholesterol from the plasma of patients with obstructive liver disease.	Phosphatidylcholines	112-131	lecithin-cholesterol acyltransferase	Homo sapiens	52-56
140874-1	1977	The Ca2+-ATPase of sarcoplasmic reticulum can be reversibly delipidated by precipitation with polyethyleneglycol in the presence of deoxycholate and glycerol to as low as 4 mol of phospholipid/mol of enzyme polypeptide and can then be reactivated to 90% of its original ATPase activity by the addition of phosphatidylcholine.	Phosphatidylcholines	305-324	dynein axonemal heavy chain 8	Homo sapiens	9-15
861238-1	1977	The relationship between lipoprotein lipase activity and uptake of triacylglycerol, cholesterol and phosphatidylcholine from chylomicrons was studied in mammary gland and adipose tissue of rats lactating 6--7 days.	Phosphatidylcholines	100-119	lipoprotein lipase	Rattus norvegicus	25-43
856267-5	1977	Removal of cholesterol from resealed ghosts by incubation with egg phosphatidylcholine liposomes resulted in the binding of cytochrome b5 to the outer surface of the treated ghosts.	Phosphatidylcholines	67-86	cytochrome b5 type A	Homo sapiens	124-137
849477-0	1977	Leakage of sucrose from phosphatidylcholine liposomes induced by interaction with serum albumin.	Phosphatidylcholines	24-43	albumin	Rattus norvegicus	82-95
837884-1	1977	The addition of prolactin to the 150,000 x g sedimented fraction of mammary gland homogenates increased by about two-fold the rate of [3H]-arachidonic acid released from phosphatidyl choline.	Phosphatidylcholines	170-190	prolactin	Homo sapiens	16-25
837884-3	1977	The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland.	Phosphatidylcholines	51-71	prolactin	Homo sapiens	86-95
837884-3	1977	The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland.	Phosphatidylcholines	51-71	phospholipase A and acyltransferase 1	Homo sapiens	107-122
837884-3	1977	The enhanced rate of arachidonic acid release from phosphatidyl choline suggests that prolactin stimulates phospholipase A activity and this may be the primary site of action of prolactin in the mammary gland.	Phosphatidylcholines	51-71	prolactin	Homo sapiens	178-187
849477-1	1977	Liposomes composed of rat-liver phosphatidylcholine rapidly lose entrapped sucrose when incubated in presence of blood or of solutions of bovine serum albumin.	Phosphatidylcholines	32-51	albumin	Rattus norvegicus	145-158
190241-6	1977	Phospholipase A treatment of intact microsomes in the presence of albumin hydrolyzed all of the phosphatidylethanolamine, phosphatidylserine, and 55% of the phosphatidylcholine.	Phosphatidylcholines	157-176	phospholipase A and acyltransferase 1	Homo sapiens	0-15
849774-0	1977	[Action of chlorphentermine on the hydrolysis of phosphatidyl choline by phospholipase A2 (author"s transl)].	Phosphatidylcholines	49-69	phospholipase A2 group IB	Homo sapiens	73-89
952985-12	1976	As in seminal plasma phospholipase A2, the activity in crude Naja naja venom towards sonicated radioactively labelled phosphatidylcholine was stimulated at low and inhibited at high concentrations of dibucaine and chloropromazine, for example.	Phosphatidylcholines	118-137	phospholipase A2 group IB	Homo sapiens	21-37
187172-4	1976	Analysis of the myelin pellet obtained after centrifugation of the myelin sample incubated with snake venom or phospholipase A alone showed conversion of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine into their corresponding lyso compounds.	Phosphatidylcholines	154-173	phospholipase A and acyltransferase 1	Homo sapiens	111-126
1010852-0	1976	Release of fatty acids from phosphatidylcholine by lecithin-cholesterol acyltransferase.	Phosphatidylcholines	28-47	lecithin-cholesterol acyltransferase	Homo sapiens	51-87
1010852-1	1976	Partially purified lecithin-cholesterol acyltransferase [EC 2.3.1.43] from human plasma released fatty acids from phosphatidylcholine.	Phosphatidylcholines	114-133	lecithin-cholesterol acyltransferase	Homo sapiens	19-55
191277-1	1976	In sympathetic ganglia stimulated in the presence of HC-3, the reduction in number of synaptic vesicles was observed to be accompanied by a significant decrease of the ganglionic phosphatidylcholine content.	Phosphatidylcholines	179-198	CYCS pseudogene 24	Homo sapiens	53-57
12743-2	1976	The adsorption of [14C]carboxymethylated glyceraldehyde 3-phosphate dehydrogenase to negatively charged liposomes of phsphatidic acid/phosphatidylcholine (3:7, w/w) was investigated.	Phosphatidylcholines	134-153	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-81
188457-2	1976	2H and 31P spin-lattice relaxation times (T1) were studied for inverted egg phosphatidylcholine micelles in CCl4 as functions of 2H2O concentration.	Phosphatidylcholines	76-95	C-C motif chemokine ligand 4	Homo sapiens	108-112
992582-5	1976	Analyses of the liver phosphatidylcholine by specific enzymatic hydrolysis with phospholipase A2, 6 h after the application, showed that in the isolated PC 9 times more labelled fatty acids from the original 1-position were present than from the corresponding 2-position.	Phosphatidylcholines	22-41	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	153-157
949475-6	1976	Bilayers prepared from extracted disk lipids had a microviscosity which was about one-fourth that of the intact disk membrane, demonstrating that rhodopsin hinders the mobility of the hydrocarbon chains of the disk phospholipids or egg phosphatidylcholine had identical microviscosities despite the much higher degree of unsaturation of the disk phospholipids.	Phosphatidylcholines	236-255	rhodopsin	Bos taurus	146-155
952908-8	1976	Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen.	Phosphatidylcholines	92-111	fibrinogen beta chain	Homo sapiens	6-16
952908-8	1976	Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen.	Phosphatidylcholines	179-198	fibrinogen beta chain	Homo sapiens	6-16
949490-0	1976	Hydrolysis of chylomicron phosphatidylcholine in vitro by lipoprotein lipase, phospholipase A2 and phospholipase C. The effects of lipoprotein lipase, phospholipase A2 and phospholipase C on chylomicron phosphatidylcholine and triacylglycerol were studied with rat lymph chylomicrons containing phosphatidylcholine labeled with [14C]oleic acid.	Phosphatidylcholines	26-45	lipoprotein lipase	Rattus norvegicus	58-76
178361-5	1976	These labeled phosphatidylcholine molecules were incorporated into the membrane by incubation of the red cells at 22 degrees C with sonicated spin-labed phosphatidylcholine vesicles from which all traces of free fatty acids and lyso derivatives were carefully removed by bovine serum albumin treatment.	Phosphatidylcholines	153-172	spindlin 1	Homo sapiens	142-146
949490-0	1976	Hydrolysis of chylomicron phosphatidylcholine in vitro by lipoprotein lipase, phospholipase A2 and phospholipase C. The effects of lipoprotein lipase, phospholipase A2 and phospholipase C on chylomicron phosphatidylcholine and triacylglycerol were studied with rat lymph chylomicrons containing phosphatidylcholine labeled with [14C]oleic acid.	Phosphatidylcholines	26-45	phospholipase A2 group IB	Rattus norvegicus	78-94
949490-4	1976	Analyses of hydrolytic products showed that lipoprotein lipase cleaved the 1-acyl ester bond of phosphatidylcholine.	Phosphatidylcholines	96-115	lipoprotein lipase	Rattus norvegicus	44-62
949490-7	1976	The resultant phosphatidylcholine-deficient chylomicrons, which could be concentrated by ultra-centrifugation and resuspended in incubation medium, were readily depleted of triacylglycerol when incubated with lipoprotein lipase.	Phosphatidylcholines	14-33	lipoprotein lipase	Rattus norvegicus	209-227
178361-3	1976	Spin labeled analogs of phosphatidylcholine were used to study the transverse diffusion (flip-flop) of phospholipids in the erythrocyte membrane.	Phosphatidylcholines	24-43	spindlin 1	Homo sapiens	0-4
178361-5	1976	These labeled phosphatidylcholine molecules were incorporated into the membrane by incubation of the red cells at 22 degrees C with sonicated spin-labed phosphatidylcholine vesicles from which all traces of free fatty acids and lyso derivatives were carefully removed by bovine serum albumin treatment.	Phosphatidylcholines	14-33	spindlin 1	Homo sapiens	142-146
1276220-4	1976	Pancreatic phospholipase A2, an enzyme unable to hydrolyse the phospholipids of intact erythrocytes, partially degrades phosphatidylcholine and phosphatidylethanolamine of erythrocytes pretreated with hexanol or SH reagents.	Phosphatidylcholines	120-139	phospholipase A2 group IB	Homo sapiens	11-27
178361-7	1976	When spin-labeled phosphatidylcholine, having a nitroxide on the beta chain but near the polar head-group, was incorporated into the erythrocyte membrane, ascorbate treatment at 0 degrees C allows selective reduction of the signal coming from the outer layer of the membrane.	Phosphatidylcholines	18-37	spindlin 1	Homo sapiens	5-9
178361-9	1976	The anisotropic distribution of spin-labeled phosphatidylcholine in the erythrocyte membrane was found to be stable at 22 and 37 degrees C for more than 4 h. It is therefore concluded that the rate of outside-inside and inside-outside transition is so slow that the anisotropic distribution of the phospholipids in the erythrocyte membrane can be maintained during cell life.	Phosphatidylcholines	45-64	spindlin 1	Homo sapiens	32-36
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	13-32	spindlin 1	Rattus norvegicus	0-4
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	13-32	spindlin 1	Rattus norvegicus	169-173
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	13-32	spindlin 1	Rattus norvegicus	237-241
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	0-4
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	169-173
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	0-4
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	169-173
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	0-4
178362-3	1976	Spin-labeled phosphatidylcholine was incorporated into the membrane of isolated "inner membrane+matrix" particles of rat liver mitochondria by incubation with sonicated spin-labeled phosphatidylcholine vesicles at 22 degrees C. When the spin label was on the acyl chain the incorporation of phosphatidylcholine into the membrane was stimulated by the presence of the phosphatidylcholine exchange protein extracted from rat or beef liver.	Phosphatidylcholines	182-201	spindlin 1	Rattus norvegicus	169-173
178362-6	1976	On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane.	Phosphatidylcholines	36-55	spindlin 1	Rattus norvegicus	23-27
178362-6	1976	On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane.	Phosphatidylcholines	36-55	spindlin 1	Rattus norvegicus	218-222
178362-6	1976	On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane.	Phosphatidylcholines	231-250	spindlin 1	Rattus norvegicus	23-27
178362-6	1976	On the other hand when spin-labeled phosphatidylcholine was incorporated in the presence of the exchange protein most of the EPR signal could be destroyed by the ascorbate treatment at 0 degrees C, indicating that the spin-labeled phosphatidylcholine had been selectively incorporated in the outer layer of the membrane.	Phosphatidylcholines	231-250	spindlin 1	Rattus norvegicus	218-222
178362-8	1976	The anisotropic distribution of spin-labeled phosphatidylcholine in the mitochondrial membrane was found to be stable at 25 degrees C for more than 2 h. It is therefore concluded that the rate of outside-inside and inside-outside transitions are extremely slow (half-life greater than 24 h).	Phosphatidylcholines	45-64	spindlin 1	Rattus norvegicus	32-36
1252495-2	1976	When platelets, so labelled, were washed and treated with thrombin, there was a major decrease in the radioactivity of phosphatidylcholine and phosphatidylinositol.	Phosphatidylcholines	119-138	coagulation factor II, thrombin	Homo sapiens	58-66
188485-2	1976	We have studied the interaction of an apolipoprotein from human very low density lipoproteins (apoC-III) with egg yolk phosphatidylcholine in the form of single- and multi-bilayer vesicles.	Phosphatidylcholines	119-138	apolipoprotein C3	Homo sapiens	95-103
167813-1	1975	The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates.	Phosphatidylcholines	169-188	apolipoprotein A1	Homo sapiens	29-35
1194272-4	1975	Only small increases in s20 (from 2.67 up to 3.82 X 10(-13) s) and density (from 1.025 up to 1.042 g ml(-1)) were observed upon binding of the cytochrome b5 to phosphatidylcholine vesicles.	Phosphatidylcholines	160-179	cytochrome b5	Oryctolagus cuniculus	143-156
1194272-6	1975	Cytochrome b5 was also incubated with phosphatidylcholine vesicles prepared with ferricyanide trapped inside.	Phosphatidylcholines	38-57	cytochrome b5	Oryctolagus cuniculus	0-13
170257-6	1975	Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol.	Phosphatidylcholines	23-43	apolipoprotein A2	Homo sapiens	49-56
170257-6	1975	Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol.	Phosphatidylcholines	23-43	apolipoprotein C1	Homo sapiens	58-64
170257-6	1975	Complexes of saturated phosphatidylcholines with apoA-II, apoC-I, or apoC-III were the most effective in releasing cellular sterol.	Phosphatidylcholines	23-43	apolipoprotein C3	Homo sapiens	69-77
1194272-0	1975	Effect of cytochrome b5 on the size, density, and permeability of phosphatidylcholine vesicles.	Phosphatidylcholines	66-85	cytochrome b5	Oryctolagus cuniculus	10-23
1194272-1	1975	Cytochrome b5, isolated from rabbit liver by a procedure using detergent, was incubated with phosphatidylcholine bilayer vesicles at 37 degrees for 30 min.	Phosphatidylcholines	93-112	cytochrome b5	Oryctolagus cuniculus	0-13
1194272-2	1975	A comparison of a number of physical properties was made between the cytochrome b5-phosphatidylcholine complex (at a molar ratio of 1:1000) and the phosphatidylcholine vesicles.	Phosphatidylcholines	83-102	cytochrome b5	Oryctolagus cuniculus	69-82
1174523-1	1975	The phospholipases A2, C and D have been used to investigate the localization of phosphatidylcholine in the phosphatidylcholine exchange protein from beef liver.	Phosphatidylcholines	81-100	phospholipase A2 group IB	Homo sapiens	4-30
1174523-1	1975	The phospholipases A2, C and D have been used to investigate the localization of phosphatidylcholine in the phosphatidylcholine exchange protein from beef liver.	Phosphatidylcholines	108-127	phospholipase A2 group IB	Homo sapiens	4-30
167813-1	1975	The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates.	Phosphatidylcholines	169-188	apolipoprotein C1	Homo sapiens	40-46
167813-1	1975	The human plasma apoproteins apoA-I and apoC-I enhanced the activity of partially purified lecithin: cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine:cholesterol single bilayer vesicles as substrates.	Phosphatidylcholines	169-188	lecithin-cholesterol acyltransferase	Homo sapiens	91-128
167813-3	1975	The activation by apoA-I and apoC-I differed, depending upon the nature of the hydrocarbon chains of phosphatidylcholine acyl donor.	Phosphatidylcholines	101-120	apolipoprotein A1	Homo sapiens	18-24
167813-3	1975	The activation by apoA-I and apoC-I differed, depending upon the nature of the hydrocarbon chains of phosphatidylcholine acyl donor.	Phosphatidylcholines	101-120	apolipoprotein C1	Homo sapiens	29-35
167813-4	1975	ApoA-I was most effective with a phosphatidylcholine containing an unsaturated fatty acyl chain.	Phosphatidylcholines	33-52	apolipoprotein A1	Homo sapiens	0-6
167813-5	1975	ApoC-I activated LCAT to the same extent with both saturated and unsaturated phosphatidylcholine substrates.	Phosphatidylcholines	77-96	apolipoprotein C1	Homo sapiens	0-6
167813-5	1975	ApoC-I activated LCAT to the same extent with both saturated and unsaturated phosphatidylcholine substrates.	Phosphatidylcholines	77-96	lecithin-cholesterol acyltransferase	Homo sapiens	17-21
168873-5	1975	This indicated that CDP-choline was formed at a similar rate from phosphorylcholine and phosphatidylcholines, the latter probably through the reverse reaction of cholinephosphotransferase (EC 2.7.8.2.).	Phosphatidylcholines	88-108	cut-like homeobox 1	Rattus norvegicus	20-23
1123345-5	1975	The rate of phosphatidylcholine synthesis via the CDP-ester pathway responded in a way analogous to that of phosphatidylethanolamine synthesis upon the addition of choline and fatty acid, except that a 10- to 20-fold higher concentration of choline was required for maximal stimulation, probably due to the rapid oxidation of choline to betaine.	Phosphatidylcholines	12-31	cut-like homeobox 1	Rattus norvegicus	50-53
1125185-6	1975	It was, however, substantially reduced when NO3 minus was substituted for Cl minus on the side of the bilayer initially free of 36-Cl, or if I minus was added to the aquesous phases in the concentration range of 0.001-0.1 M. These results strongly suggested that the electrically silent flux of 36-Cl is primarily a carrier mediated diffusion process in which phosphatidylcholine acts as the carrier species.	Phosphatidylcholines	360-379	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
173287-1	1975	Hydrolysis of phosphatidylcholine by phospholipase A2 of synaptic membranes i n Tris-CHl buffer was stimulated by cyclic AMP, cyclic GMP, cyclic CMP, cyclic UMP and adenosine (0.1 mm).	Phosphatidylcholines	14-33	phospholipase A2 group IB	Homo sapiens	37-53
1123345-11	1975	Under these conditions the rate of phosphatidylcholine synthesis via this pathway was 20 to 40 percent of that via diacylglycerols and CDP-choline.	Phosphatidylcholines	35-54	cut-like homeobox 1	Rattus norvegicus	135-138
1124312-2	1975	Thin layer and gas liquid chromatographic analysis of the fatty acid methyl esters derived from liver microsomal phosphatidylcholine from animals treated with 14CC1-4 revealed a very similar composition to that observed during the analysis of the reaction products arised by the in vitro benzoyl peroxide initiated CC1-4 chemical addition to double bonds of fatty acid methyl esters or to fatty acids in phospholipids later transformed to methyl esters.	Phosphatidylcholines	113-132	C-C motif chemokine ligand 14	Homo sapiens	161-166
1120108-0	1975	The binding of deoxycholate, Triton X-100, sodium dodecyl sulfate, and phosphatidylcholine vesicles to cytochrome b5.	Phosphatidylcholines	71-90	cytochrome b5 type A	Homo sapiens	103-116
50420-3	1975	On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine.	Phosphatidylcholines	87-106	lipase H	Homo sapiens	211-227
50420-3	1975	On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine.	Phosphatidylcholines	292-312	lipase H	Homo sapiens	211-227
16659017-10	1975	Phosphatidylcholine and phosphatidylethanolamine synthesis paralleled the activity profiles of catalase and malate synthetase, as well as the levels of endogenous diglycerides.	Phosphatidylcholines	0-19	catalase isozyme 3	Cucumis sativus	95-103
4474005-0	1974	The activity of phospholipase A2 in reversed micelles of phosphatidylcholine in diethyl ether: effect of water and cations.	Phosphatidylcholines	57-76	phospholipase A2 group IB	Homo sapiens	16-32
4374941-10	1974	It was concluded that the dietary phosphatidylcholine is hydrolysed in the intestinal lumen by the pancreatic phospholipase A to 1-acylglycerylphosphorylcholine, which on entering the mucosal cell is partly reacylated to phosphatidylcholine, and the rest is further hydrolysed to glycerylphosphorylcholine, glycerophosphate, glycerol and P(i).	Phosphatidylcholines	34-53	phospholipase A and acyltransferase 1	Rattus norvegicus	110-125
4372633-5	1974	Apolipoprotein A-I preferentially binds phosphatidylcholine, although its lipid-binding capacity is smaller than that of apolipoprotein A-II.	Phosphatidylcholines	40-59	apolipoprotein A1	Homo sapiens	0-18
4374941-10	1974	It was concluded that the dietary phosphatidylcholine is hydrolysed in the intestinal lumen by the pancreatic phospholipase A to 1-acylglycerylphosphorylcholine, which on entering the mucosal cell is partly reacylated to phosphatidylcholine, and the rest is further hydrolysed to glycerylphosphorylcholine, glycerophosphate, glycerol and P(i).	Phosphatidylcholines	221-240	phospholipase A and acyltransferase 1	Rattus norvegicus	110-125
4212407-0	1974	The effect of insulin on the permeability of phosphatidyl choline bimolecular membranes to glucose.	Phosphatidylcholines	45-65	insulin	Homo sapiens	14-21
4407745-0	1974	Hydrolysis of phosphatidylcholine liposomes by pancreatic phospholipase A2 at the transition temperature.	Phosphatidylcholines	14-33	phospholipase A2 group IB	Homo sapiens	58-74
5158903-11	1971	Insulin decreased the [(14)C]glucose solubilized by phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, but not by sphingomyelin.	Phosphatidylcholines	52-71	insulin	Homo sapiens	0-7
4357738-1	1973	Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine.	Phosphatidylcholines	91-110	NLR family pyrin domain containing 3	Homo sapiens	51-84
4428490-0	1974	Effect of pregnancy and insulin administration on fatty acid distribution in phosphatidylcholine of maternal and fetal liver and lung in the rabbit.	Phosphatidylcholines	77-96	insulin	Oryctolagus cuniculus	24-31
4798723-0	1973	Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: surface dilution kinetics and the effect of thermotropic phase transitions.	Phosphatidylcholines	34-53	phospholipase A2 group IB	Homo sapiens	0-16
4349484-11	1973	Their abnormal composition is compatible with the possibility that lecithin:cholesterol acyltransferase normally decreases the triglyceride and phosphatidylcholine and increases the cholesteryl ester of very low density and low density plasma lipoproteins in vivo.	Phosphatidylcholines	144-163	lecithin-cholesterol acyltransferase	Homo sapiens	67-103
4341702-2	1972	The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines.	Phosphatidylcholines	50-69	rhodopsin	Homo sapiens	13-22
4341702-2	1972	The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines.	Phosphatidylcholines	176-196	rhodopsin	Homo sapiens	13-22
4187623-4	1969	This esterification was accomplished by the transfer of fatty acids from the C-2 position of lecithin (phosphatidylcholine) to cholesterol.	Phosphatidylcholines	103-122	complement C2	Oryctolagus cuniculus	77-80
5166856-0	1971	[Effect of phospholipase A from snake venom on phosphatidylcholine, phosphatidylethanolamine and on the corresponding plasmalogens.	Phosphatidylcholines	47-66	phospholipase A and acyltransferase 1	Homo sapiens	11-26
33713833-4	2021	The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation.	Phosphatidylcholines	108-127	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	35-40
5388143-2	1969	The interactions between cytochrome c (native and [(14)C]carboxymethylated) and monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin at the air/water interface was investigated by measurements of surface radioactivity, pressure and potential.	Phosphatidylcholines	94-113	cytochrome c, somatic	Homo sapiens	25-37
5388143-4	1969	On a subphase of 10mm-or m-sodium chloride, penetration of cytochrome c into egg phosphatidylcholine monolayers, as measured by an increase of surface pressure, and the number of molecules penetrating, as judged by surface radioactivity, were inversely proportional to the initial pressure of the monolayer and became zero at 20dynes/cm.	Phosphatidylcholines	81-100	cytochrome c, somatic	Homo sapiens	59-71
5388143-7	1969	Penetrated cytochrome c could be removed almost entirely by compression of the phosphatidylcholine monolayer above 20dynes/cm.	Phosphatidylcholines	79-98	cytochrome c, somatic	Homo sapiens	11-23
33713833-4	2021	The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation.	Phosphatidylcholines	129-131	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	35-40
33862056-0	2021	Binding of liposomes composed of phosphatidylcholine to scavenger receptor class B type 1 and its modulation by phosphatidic acid in HEK293T cells.	Phosphatidylcholines	33-52	scavenger receptor class B member 1	Homo sapiens	56-89
34035440-3	2021	Here, we present the cryo-EM structures of full-length rat IP3R1 reconstituted in lipid nanodisc and detergent solubilized in the presence of phosphatidylcholine determined in ligand-free, closed states by single-particle electron cryo-microscopy.	Phosphatidylcholines	142-161	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	59-64
33740632-5	2021	Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed.	Phosphatidylcholines	99-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-22
33740632-5	2021	Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed.	Phosphatidylcholines	120-122	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-22
33184906-8	2021	Additionally, chromatography assay evidenced that NTE overexpression significantly reduced the level of phosphatidylcholine (PC) of HUVECs, but NTE shRNA obviously increased the level of PC of HUVECs.	Phosphatidylcholines	104-123	patatin like phospholipase domain containing 6	Homo sapiens	50-53
33184906-8	2021	Additionally, chromatography assay evidenced that NTE overexpression significantly reduced the level of phosphatidylcholine (PC) of HUVECs, but NTE shRNA obviously increased the level of PC of HUVECs.	Phosphatidylcholines	125-127	patatin like phospholipase domain containing 6	Homo sapiens	50-53
33705949-0	2021	Dietary phosphatidylcholine supplementation reduces atherosclerosis in Ldlr-/- male mice2.	Phosphatidylcholines	8-27	low density lipoprotein receptor	Mus musculus	71-75
34014977-0	2021	Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways.	Phosphatidylcholines	0-19	CREB-H transcription factor homolog let-607	Caenorhabditis elegans	51-58
34023500-13	2021	From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit.	Phosphatidylcholines	92-111	RELA proto-oncogene, NF-kB subunit	Homo sapiens	150-154
34023500-13	2021	From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit.	Phosphatidylcholines	92-111	RELA proto-oncogene, NF-kB subunit	Homo sapiens	174-187
34023500-13	2021	From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit.	Phosphatidylcholines	113-119	RELA proto-oncogene, NF-kB subunit	Homo sapiens	150-154
34023500-13	2021	From the computational analyses, we observed that the genes involved in the biosynthesis of phosphatidylcholine (PtdCho) indirectly interact with the RELA, which encodes the NF-kappaB p65 subunit.	Phosphatidylcholines	113-119	RELA proto-oncogene, NF-kB subunit	Homo sapiens	174-187
34014977-0	2021	Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways.	Phosphatidylcholines	0-19	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	63-69
34014977-6	2021	SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2.	Phosphatidylcholines	63-65	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	84-90
34014977-6	2021	SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2.	Phosphatidylcholines	63-65	Inositol 1,4,5-trisphosphate receptor itr-1	Caenorhabditis elegans	99-104
34014977-6	2021	SMS-5 reduces the contents of unsaturated phosphatidylcholine (PC), which activates DAF-16 through ITR-1-dependent calcium signaling and calcium-sensitive kinase PKC-2.	Phosphatidylcholines	63-65	Protein kinase C;Protein kinase C-like 2	Caenorhabditis elegans	162-167
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	178-197	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	178-197	ATP binding cassette subfamily B member 4	Homo sapiens	19-48
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	178-197	ATP binding cassette subfamily B member 4	Homo sapiens	50-54
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	199-201	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	199-201	ATP binding cassette subfamily B member 4	Homo sapiens	19-48
34022183-1	2021	ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	199-201	ATP binding cassette subfamily B member 4	Homo sapiens	50-54
33676699-9	2021	Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	39-83
33945282-8	2021	Our results show that alpha-Syn oligomers grown in the presence of phosphatidylcholine have a distinctly different structure than oligomers grown in the presence of phosphatidylserine.	Phosphatidylcholines	67-86	synuclein alpha	Homo sapiens	22-31
34003451-7	2021	HSPA8 showed high selectivity for negatively charged phospholipids, such as phosphatidylserine and cardiolipin, and low affinity for phosphatidylcholine.	Phosphatidylcholines	133-152	heat shock protein family A (Hsp70) member 8	Homo sapiens	0-5
33955494-6	2021	Enzymatic analysis showed that NPC4 hydrolyzed GIPC and displayed a higher activity toward GIPC as a substrate than toward the common glycerophospholipid phosphatidylcholine.	Phosphatidylcholines	154-173	non-specific phospholipase C4	Arabidopsis thaliana	31-35
33545384-3	2021	SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride.	Phosphatidylcholines	96-115	sphingomyelin synthase 1	Mus musculus	21-51
33545384-3	2021	SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride.	Phosphatidylcholines	96-115	sphingomyelin synthase 1	Mus musculus	53-57
33676699-9	2021	Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation.	Phosphatidylcholines	0-19	phosphatidylethanolamine N-methyltransferase	Mus musculus	85-89
33676699-9	2021	Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	39-83
33676699-9	2021	Phosphatidylcholine (PC) synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) pathway might be a mechanism of self-protection in animals against PFOS induced inflammation.	Phosphatidylcholines	21-23	phosphatidylethanolamine N-methyltransferase	Mus musculus	85-89
33917451-7	2021	We find that, compared to its C-terminus alone, the full-length perilipin 3 has a higher affinity for both a neat oil/aqueous interface and a phosphatidylcholine (PC) coated oil/aqueous interface.	Phosphatidylcholines	142-161	perilipin 3	Homo sapiens	64-75
33617914-2	2021	The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	104-123	patatin like phospholipase domain containing 6	Homo sapiens	52-78
33617914-2	2021	The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	104-123	patatin like phospholipase domain containing 6	Homo sapiens	80-83
33617914-2	2021	The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	125-127	patatin like phospholipase domain containing 6	Homo sapiens	52-78
33617914-2	2021	The primary target protein of OP"s neurotoxicity is neuropathy target esterase (NTE), which can convert phosphatidylcholine (PC) to glycerophosphocholine (GPC).	Phosphatidylcholines	125-127	patatin like phospholipase domain containing 6	Homo sapiens	80-83
33917451-7	2021	We find that, compared to its C-terminus alone, the full-length perilipin 3 has a higher affinity for both a neat oil/aqueous interface and a phosphatidylcholine (PC) coated oil/aqueous interface.	Phosphatidylcholines	163-165	perilipin 3	Homo sapiens	64-75
33789160-1	2021	The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product.	Phosphatidylcholines	27-46	cut like homeobox 1	Homo sapiens	112-115
33504931-9	2021	In addition, a network of 89 metabolites, primarily phosphatidylcholines, plasmalogens, sphingomyelins, and ceramides showed consistent negative correlations with insulin at visit 1 and post-challenge glucose at visit 2, while positive correlation with adiponectin at visit 2.	Phosphatidylcholines	52-72	insulin	Homo sapiens	163-170
33504931-9	2021	In addition, a network of 89 metabolites, primarily phosphatidylcholines, plasmalogens, sphingomyelins, and ceramides showed consistent negative correlations with insulin at visit 1 and post-challenge glucose at visit 2, while positive correlation with adiponectin at visit 2.	Phosphatidylcholines	52-72	adiponectin, C1Q and collagen domain containing	Homo sapiens	253-264
33450726-0	2021	Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY.	Phosphatidylcholines	58-78	choline/ethanolamine phosphotransferase 1	Homo sapiens	23-28
33450726-0	2021	Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY.	Phosphatidylcholines	58-78	patatin like phospholipase domain containing 2	Homo sapiens	33-37
33450726-0	2021	Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY.	Phosphatidylcholines	58-78	glucokinase	Homo sapiens	152-155
33450726-5	2021	At false-discovery rate (FDR) < 0.05, several phosphatidylcholines (PCs) and plasmalogen PCs were specifically increased in GCK-MODY, while triacylglycerols (TAGs) and diacylglycerols (DAGs) were reduced.	Phosphatidylcholines	46-66	glucokinase	Homo sapiens	124-127
33665770-5	2021	Results from a sulfating activity assay of hSULT1E1 using 1-hydroxypyrene as the substrate demonstrated that Ox-LDL, LPC, and PAF markedly decreased the sulfating activity of hSULT1E1, whereas native LDL and 1-palmitoyl-2-(5"-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC) as one of the oxidized phosphatidylcholines showed the opposite effect.	Phosphatidylcholines	299-319	sulfotransferase family 1E member 1	Homo sapiens	175-183
33789160-1	2021	The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product.	Phosphatidylcholines	27-46	cut like homeobox 1	Homo sapiens	128-131
33744860-9	2021	Multiomics analysis revealed glycerophospholipid metabolism to be a common pathway and phosphatidylcholine the main metabolite differentially enriched between the Rb1 and model groups.	Phosphatidylcholines	87-106	RB transcriptional corepressor 1	Mus musculus	163-166
33744860-10	2021	Results from fecal transplanted germ-free mice suggest that to suppress hyperlipidemia, Rb1 regulates gut microbiota by regulating the synthesis and decomposition of phosphatidylcholine in glycerophospholipid metabolism, which in turn decreases serum total cholesterol.	Phosphatidylcholines	166-185	RB transcriptional corepressor 1	Mus musculus	88-91
33722607-5	2021	Metabolic labeling experiments reveal that in the absence of exogenously supplied Cho, PE biosynthesized via Psd2 is mostly directed to the methylation pathway for PC biosynthesis and is unavailable for replenishing mitochondrial PE in Psd1-deleted cells.	Phosphatidylcholines	164-166	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	109-113
33722607-6	2021	In this setting, stimulating the Kennedy pathway for PC biosynthesis by Cho spares Psd2-synthesized PE from the methylation pathway and redirects it to the mitochondria.	Phosphatidylcholines	53-55	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	83-87
33439214-6	2021	Moreover, de novo-synthesized phosphatidylcholine is incorporated into autophagosomes preferentially and shows symmetrical distribution in autophagosomes within 30 min after synthesis, whereas this symmetrical distribution is compromised in yeast expressing an Atg9 mutant.	Phosphatidylcholines	30-49	autophagy protein ATG9	Saccharomyces cerevisiae S288C	261-265
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Phosphatidylcholines	73-92	ATP binding cassette subfamily B member 11	Homo sapiens	26-32
33574922-1	2021	Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine.	Phosphatidylcholines	94-113	choline kinase alpha	Homo sapiens	0-14
33574922-1	2021	Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine.	Phosphatidylcholines	94-113	choline kinase alpha	Homo sapiens	16-19
33574922-1	2021	Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine.	Phosphatidylcholines	94-113	cut like homeobox 1	Homo sapiens	53-56
33622719-9	2021	Finally, pre-ATI levels of several phosphatidylcholine species (lysophosphatidylcholine precursors) correlated strongly with higher pre-ATI levels of HIV DNA in peripheral CD4+ T cells.	Phosphatidylcholines	35-54	CD4 molecule	Homo sapiens	172-175
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Phosphatidylcholines	73-92	ATP binding cassette subfamily B member 4	Homo sapiens	54-59
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Phosphatidylcholines	73-92	ATP binding cassette subfamily B member 1	Homo sapiens	26-31
33606602-10	2021	Daily co-administration of CDP-diacylglycerol significantly enhanced the beneficial effects of CDP-choline and also modified the ATII cell lipidome, reversing the infection-induced decrease in phosphatidylcholine and increasing levels of most other lipid classes in ATII cells.	Phosphatidylcholines	193-212	cut like homeobox 1	Homo sapiens	27-30
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Phosphatidylcholines	73-92	ATP binding cassette subfamily C member 2	Homo sapiens	164-169
33670702-10	2021	There was a significant increase in cholesteryl ester and phosphatidylcholine content in STAR KO cell lipid droplets, but the most abundant increase was in the amount of diacylglycerol (DAG); DAG 38:1 was the predominantly affected species.	Phosphatidylcholines	58-77	steroidogenic acute regulatory protein	Mus musculus	89-93
33669841-0	2021	Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFalpha Gene Expression in Macrophages via a cPLA2alpha/COX-1 Pathway.	Phosphatidylcholines	0-27	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	107-117
33669841-0	2021	Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFalpha Gene Expression in Macrophages via a cPLA2alpha/COX-1 Pathway.	Phosphatidylcholines	0-27	prostaglandin-endoperoxide synthase 1	Mus musculus	118-123
33673393-5	2021	A shift of the dominant phospholipid phosphatidylcholine with saturated fatty acids in the DRM to unsaturated species in the non-DRM fractions correlated with the GSL distribution.	Phosphatidylcholines	37-56	cathepsin A	Homo sapiens	163-166
33673027-7	2021	For instance, LacCer activates an enzyme, cytosolic phospholipase A2 (cPLA2), which cleaves arachidonic acid from phosphatidylcholine.	Phosphatidylcholines	114-133	phospholipase A2 group IVA	Homo sapiens	42-68
33673027-7	2021	For instance, LacCer activates an enzyme, cytosolic phospholipase A2 (cPLA2), which cleaves arachidonic acid from phosphatidylcholine.	Phosphatidylcholines	114-133	phospholipase A2 group IVA	Homo sapiens	70-75
33432959-2	2021	A phosphatidyl choline reversed choline phosphate lipid (CP-Lip) was synthesized and modified with a PD-L1 antibody (CP-alphaPDL).	Phosphatidylcholines	2-22	CD274 molecule	Homo sapiens	101-106
33525659-8	2021	However, seven lipid species, including phosphatidylcholines, phosphatidylethanolamines, and triacylglycerol, were downregulated in the ELOVL5-Mo-derived blastocysts compared with the biological control.	Phosphatidylcholines	40-60	ELOVL fatty acid elongase 5	Homo sapiens	136-142
33281496-4	2021	We discovered that phosphatidylcholine bound to rhodopsin with a greater affinity than phosphatidylserine or phosphatidylethanolamine, and that binding of all lipids was influenced by zinc but with different effects.	Phosphatidylcholines	19-38	rhodopsin	Homo sapiens	48-57
32888232-7	2021	Finally, serum IgM autoantibodies to double stranded DNA and phosphatidylcholine were increased in resting 10-15 week-old mice lacking GPR43.	Phosphatidylcholines	61-80	free fatty acid receptor 2	Mus musculus	135-140
33360238-0	2021	The TOC159 null mutant of Arabidopsis thaliana is impaired in the accumulation of plastid lipids and phosphatidylcholine.	Phosphatidylcholines	101-120	translocon at the outer envelope membrane of chloroplasts 159	Arabidopsis thaliana	4-10
33360238-5	2021	Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	90-109	proton pump interactor 2	Arabidopsis thaliana	36-40
33360238-5	2021	Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).	Phosphatidylcholines	111-113	proton pump interactor 2	Arabidopsis thaliana	36-40
33521992-5	2021	The promoter regions of LPCAT1 and PCYT1A were hypermethylated, accompanied by downregulation of their messenger RNA expression, which may be involved in the regulation of PCOS through downstream glycerophospholipid metabolism and phosphatidylcholine synthesis.	Phosphatidylcholines	231-250	lysophosphatidylcholine acyltransferase 1	Homo sapiens	24-30
33521992-5	2021	The promoter regions of LPCAT1 and PCYT1A were hypermethylated, accompanied by downregulation of their messenger RNA expression, which may be involved in the regulation of PCOS through downstream glycerophospholipid metabolism and phosphatidylcholine synthesis.	Phosphatidylcholines	231-250	phosphate cytidylyltransferase 1A, choline	Homo sapiens	35-41
33415971-8	2021	Although phosphatidylcholine (PC) is the most abundant lipid species in mammalian cells, interactions of PC with alpha-syn have been largely ignored because they are substantially weaker compared with the electrostatically driven binding of negatively charged lipids.	Phosphatidylcholines	105-107	synuclein alpha	Homo sapiens	113-122
33406839-0	2021	DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor gamma in Lewis Lung Cancer Mice.	Phosphatidylcholines	17-36	peroxisome proliferator activated receptor gamma	Mus musculus	91-139
33431899-0	2021	High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance.	Phosphatidylcholines	47-66	insulin	Homo sapiens	82-89
33462674-8	2021	Generalised protection from HFD-induced lipid accumulation was observed in CD248 null mice compared to wildtype, with particular reduction noted in the lysophosphatidylcholines, phosphatidylcholines, cholesterol and carnitine.	Phosphatidylcholines	156-176	CD248 antigen, endosialin	Mus musculus	75-80
33451008-2	2021	Interactions between hBest1, sphingomyelins, phosphatidylcholines and cholesterol are crucial for hBest1 association with cell membrane domains and its biological functions.	Phosphatidylcholines	45-65	bestrophin 1	Homo sapiens	98-104
33296468-11	2021	Negative associations of kynurenic acid, 22:1 sphingomyelin, and 38:6 phosphatidylethanolamine, as well as positive associations of 32:1 phosphatidylcholine with GI and GL were also observed.	Phosphatidylcholines	137-156	G protein subunit alpha i1	Homo sapiens	162-164
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	145-164	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	0-45
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	145-164	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	47-52
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	145-164	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	227-232
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	145-164	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	320-337
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	296-315	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	0-45
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	296-315	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	47-52
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	296-315	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	227-232
33268452-1	2021	PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM).	Phosphatidylcholines	296-315	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	320-337
32828847-1	2021	Sec14, a yeast phosphatidylinositol/phosphatidylcholine transfer protein, functions at the trans-Golgi membranes.	Phosphatidylcholines	36-55	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
33060204-6	2020	The primary substrates of Dnf2 are glucosylceramide (GlcCer) and phosphatidylcholine ((PC) or their lyso-lipid derivatives), and we find that these substrates compete with each other for transport.	Phosphatidylcholines	65-84	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	26-30
33107656-2	2021	The expression of Ricinus communis (castor) OLEATE 12-HYDROXYLASE (RcFAH12) in Arabidopsis has resulted in only limited accumulation of HFA in seeds, which likely results from inefficient transfer of HFAs from their site of synthesis (phosphatidylcholine; PC) to triacylglycerol (TAG), especially at the sn-1/3 positions of TAG.	Phosphatidylcholines	235-254	oleate hydroxylase FAH12	Ricinus communis	67-74
33383652-6	2020	Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules.	Phosphatidylcholines	0-19	Ras and Rab interactor 2	Homo sapiens	76-80
33383652-6	2020	Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules.	Phosphatidylcholines	0-19	Ras and Rab interactor 2	Homo sapiens	127-131
33383652-6	2020	Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules.	Phosphatidylcholines	0-19	phospholipase A2 group V	Homo sapiens	138-144
33383652-6	2020	Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules.	Phosphatidylcholines	21-23	Ras and Rab interactor 2	Homo sapiens	76-80
33383947-2	2020	Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 11	Homo sapiens	91-97
33383947-2	2020	Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 4	Homo sapiens	133-138
33289390-0	2020	Phosphatidylcholine Ameliorates LPS-Induced Systemic Inflammation and Cognitive Impairments via Mediating the Gut-Brain Axis Balance.	Phosphatidylcholines	0-19	glucuronidase, beta	Mus musculus	110-113
33454021-1	2020	The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes.	Phosphatidylcholines	171-190	cut like homeobox 1	Homo sapiens	42-45
33454021-1	2020	The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes.	Phosphatidylcholines	171-190	cut like homeobox 1	Homo sapiens	58-61
33289390-2	2020	Phosphatidylcholine (PC) is a phospholipid found in egg yolk that has anti-inflammatory and antioxidant properties.	Phosphatidylcholines	0-19	pyruvate carboxylase	Mus musculus	21-23
32800947-5	2020	Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis.	Phosphatidylcholines	65-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
32778895-5	2020	Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransferase (PEMT) pathways for PC synthesis were assessed from incorporations of deuterated methyl-D9-choline chloride.	Phosphatidylcholines	127-129	phosphatidylethanolamine N-methyltransferase	Homo sapiens	62-106
32778895-5	2020	Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransferase (PEMT) pathways for PC synthesis were assessed from incorporations of deuterated methyl-D9-choline chloride.	Phosphatidylcholines	127-129	phosphatidylethanolamine N-methyltransferase	Homo sapiens	108-112
32778895-7	2020	Direct incorporation of methyl-D9-choline demonstrated that this transition was driven by an active CDP-choline pathway that synthesized PC enriched in species containing oleic and linoleic acids.	Phosphatidylcholines	137-139	cut like homeobox 1	Homo sapiens	100-103
32800947-5	2020	Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis.	Phosphatidylcholines	65-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
32800947-5	2020	Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis.	Phosphatidylcholines	65-84	phospholipase D1	Homo sapiens	31-37
32917728-0	2020	Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid.	Phosphatidylcholines	68-87	dynein axonemal heavy chain 8	Homo sapiens	19-25
32917728-0	2020	Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid.	Phosphatidylcholines	68-87	ATP binding cassette subfamily B member 4	Homo sapiens	38-42
32917728-0	2020	Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid.	Phosphatidylcholines	68-87	ATP binding cassette subfamily B member 4	Homo sapiens	43-48
32917728-1	2020	ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	82-101	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
32917728-1	2020	ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	82-101	ATP binding cassette subfamily B member 4	Homo sapiens	6-10
32917728-1	2020	ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	103-105	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
32917728-1	2020	ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet.	Phosphatidylcholines	103-105	ATP binding cassette subfamily B member 4	Homo sapiens	6-10
33160274-3	2020	More intriguingly, the disruption of p53 in hESCs leads to dramatic upregulation of phosphatidylcholine and decrease of total choline in both pluripotent and differentiated state of hESCs, suggesting abnormal choline metabolism in the absence of p53.	Phosphatidylcholines	84-103	tumor protein p53	Homo sapiens	37-40
32943187-3	2020	In this study, we proposed 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), the main active species of PPC, as an effective substance for the treatment of obesity-mediated disorders such as impaired fat metabolism and insulin resistance.	Phosphatidylcholines	106-109	insulin	Homo sapiens	221-228
33256620-2	2020	This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane.	Phosphatidylcholines	114-133	ATP binding cassette subfamily B member 4	Homo sapiens	18-48
33256620-2	2020	This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane.	Phosphatidylcholines	114-133	ATP binding cassette subfamily B member 4	Homo sapiens	50-54
32912785-5	2020	PEMT converts PE into PC using methyl group by S-adenosylmethionine (SAM) thus converted in S-adenosylhomocysteine (SAH).	Phosphatidylcholines	22-24	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-4
33658925-6	2020	The cytosolic phospholipase A2a (PLA2G4A), an enzyme for hydrolyzing PC to LPC, was found to be up-regulated in the colon tissue of experimental colitis mice and inflamed macrophage RAW 264.7 cells.	Phosphatidylcholines	69-71	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	33-40
33227003-6	2020	Mass spectrometry analysis revealed elevated levels of major phosphatidylcholine and phosphatidylethanolamine species in fat bodies with active Toll signaling.	Phosphatidylcholines	61-80	Toll	Drosophila melanogaster	144-148
33141558-4	2020	We find that NPC2 binds fluorescence- and spin-labeled analogues of phosphatidylcholine (PC), phosphatidylserine, phosphatidylinositol (PI), and sphingomyelin.	Phosphatidylcholines	68-87	sterol transporter	Saccharomyces cerevisiae S288C	13-17
33208465-4	2021	Mechanistically, sublethal DNA damage unexpectedly suppresses apoptotic genes in C. elegans, which in turn increases the activity of the IRE-1/XBP-1 branch of the UPRER by elevating unsaturated phosphatidylcholine (PC).	Phosphatidylcholines	215-217	Endoribonuclease;Serine/threonine-protein kinase	Caenorhabditis elegans	137-142
33208465-4	2021	Mechanistically, sublethal DNA damage unexpectedly suppresses apoptotic genes in C. elegans, which in turn increases the activity of the IRE-1/XBP-1 branch of the UPRER by elevating unsaturated phosphatidylcholine (PC).	Phosphatidylcholines	215-217	BZIP domain-containing protein	Caenorhabditis elegans	143-148
33141558-6	2020	We further identify ergosterol, PC, and PI as endogenous NPC2 ligands.	Phosphatidylcholines	32-34	sterol transporter	Saccharomyces cerevisiae S288C	57-61
33184653-12	2021	Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans" offspring compared to placebo.	Phosphatidylcholines	0-19	renin binding protein	Homo sapiens	42-45
33312389-13	2020	There were significant increase in the contents of several phosphatidylcholines, lysophosphatidylcholine, free fatty acids and carnitine in AR rats which detected by HPLC/MS.	Phosphatidylcholines	59-79	ferredoxin reductase	Rattus norvegicus	140-142
33312389-15	2020	Metabolomic studies indicated a significant increase in AR rats in the contents of several metabolites, such as phosphatidylcholines, lysophosphatidylcholine, free fatty acids and carnitine, suggesting an increasein phospholipase activity and leading to an energy metabolism imbalance with intensification of beta-oxidation.	Phosphatidylcholines	112-132	ferredoxin reductase	Rattus norvegicus	56-58
33312389-16	2020	DNA methylation may be associated with an increase in phosphatidylcholines, lysophosphatidylcholine and free fatty acids in AR rats, which may further affect energy metabolism by enhancing the tricarboxylic acid cycle in AR rats.	Phosphatidylcholines	54-74	ferredoxin reductase	Rattus norvegicus	124-126
33312389-16	2020	DNA methylation may be associated with an increase in phosphatidylcholines, lysophosphatidylcholine and free fatty acids in AR rats, which may further affect energy metabolism by enhancing the tricarboxylic acid cycle in AR rats.	Phosphatidylcholines	54-74	ferredoxin reductase	Rattus norvegicus	221-223
33184653-12	2021	Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans" offspring compared to placebo.	Phosphatidylcholines	0-19	renin binding protein	Homo sapiens	152-155
32868075-1	2020	Phosphatidylcholine-specific phospholipase Cgamma1 (PLCgamma1) is involved in regulating cell metabolism.	Phosphatidylcholines	0-19	phospholipase C, gamma 1	Rattus norvegicus	52-61
33084321-0	2020	Immobilized Phospholipase A1-Catalyzed Preparation of l-alpha-Glycerylphosphorylcholine from Phosphatidylcholine.	Phosphatidylcholines	93-112	lipase H	Homo sapiens	12-28
33084321-1	2020	This study sought to prepare a cognitive enhancer l-alpha-glycerylphosphorylcholine (l-alpha-GPC) using an immobilized Lecitase Ultra (LU, phospholipase A1) to catalyze the hydrolysis of soy phosphatidylcholine (PC).	Phosphatidylcholines	191-210	lipase H	Homo sapiens	119-155
33084321-1	2020	This study sought to prepare a cognitive enhancer l-alpha-glycerylphosphorylcholine (l-alpha-GPC) using an immobilized Lecitase Ultra (LU, phospholipase A1) to catalyze the hydrolysis of soy phosphatidylcholine (PC).	Phosphatidylcholines	94-96	lipase H	Homo sapiens	119-155
32766878-10	2020	The differential abundance of phosphatidylcholines we found can be attributed at least partially to higher expression of phosphatidylethanolamine methyl transferase (PEMT).	Phosphatidylcholines	30-50	phosphatidylethanolamine N-methyltransferase	Homo sapiens	121-164
32845134-0	2020	Identification of Phosphatidylcholine Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions.	Phosphatidylcholines	18-37	gastrin	Rattus norvegicus	81-84
32766878-10	2020	The differential abundance of phosphatidylcholines we found can be attributed at least partially to higher expression of phosphatidylethanolamine methyl transferase (PEMT).	Phosphatidylcholines	30-50	phosphatidylethanolamine N-methyltransferase	Homo sapiens	166-170
32780898-6	2020	Through lipidomic analysis, 46 lipids were differentially expressed in hyperuricemic mouse livers, and the phosphatidylcholine composition was altered, which was mediated by LPCAT3 upregulation.	Phosphatidylcholines	107-126	lysophosphatidylcholine acyltransferase 3	Mus musculus	174-180
32502648-1	2020	Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC).	Phosphatidylcholines	138-157	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
32502648-1	2020	Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC).	Phosphatidylcholines	138-157	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
32502648-1	2020	Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC).	Phosphatidylcholines	159-161	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
32502648-1	2020	Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC).	Phosphatidylcholines	159-161	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
32732347-7	2020	AtDGAT1 produces TAG from a rapidly produced phosphatidylcholine (PC)-derived DAG pool.	Phosphatidylcholines	45-64	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	0-7
32661773-4	2020	Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking.	Phosphatidylcholines	49-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
32661773-4	2020	Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking.	Phosphatidylcholines	49-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
32917955-3	2020	By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cells, we identified a group of super enhancers (SEs) that are abnormally activated in Enz-resistant CRPC cells and associated with enhanced transcription of a subset of tumor promoting genes such as CHPT1, which catalyzes phosphatidylcholine (PtdCho) synthesis and regulates choline metabolism.	Phosphatidylcholines	303-322	choline phosphotransferase 1	Mus musculus	280-285
32917955-3	2020	By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cells, we identified a group of super enhancers (SEs) that are abnormally activated in Enz-resistant CRPC cells and associated with enhanced transcription of a subset of tumor promoting genes such as CHPT1, which catalyzes phosphatidylcholine (PtdCho) synthesis and regulates choline metabolism.	Phosphatidylcholines	324-330	choline phosphotransferase 1	Mus musculus	280-285
32737074-7	2020	We reasoned that the castor LPCAT (RcLPCAT) would preferentially remove HFA from PC resulting in greater incorporation onto TAG.	Phosphatidylcholines	29-31	lysophospholipid acyltransferase 1	Ricinus communis	35-42
32732347-7	2020	AtDGAT1 produces TAG from a rapidly produced phosphatidylcholine (PC)-derived DAG pool.	Phosphatidylcholines	66-68	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	0-7
32966473-0	2020	Exogenous natural EPA-enriched phosphatidylcholine and phosphatidylethanolamine ameliorate lipid accumulation and insulin resistance via activation of PPARalpha/gamma in mice.	Phosphatidylcholines	31-50	peroxisome proliferator activated receptor alpha	Mus musculus	151-160
32735863-11	2020	We then conditioned ACAT1 with phosphatidylcholine (PC) to replace CHAPS prior to the formation of ACAT1 peptidiscs.	Phosphatidylcholines	52-54	acetyl-CoA acetyltransferase 1	Homo sapiens	20-25
32735863-11	2020	We then conditioned ACAT1 with phosphatidylcholine (PC) to replace CHAPS prior to the formation of ACAT1 peptidiscs.	Phosphatidylcholines	52-54	acetyl-CoA acetyltransferase 1	Homo sapiens	99-104
32735863-12	2020	The results showed, when PC was included, ACAT1 was present mainly in higher-order oligomeric states with greater enzymatic activity.	Phosphatidylcholines	25-27	acetyl-CoA acetyltransferase 1	Homo sapiens	42-47
32735863-13	2020	With PC present, the enzymatic activity of ACAT1 peptidiscs was protected from heat-mediated inactivation.	Phosphatidylcholines	5-7	acetyl-CoA acetyltransferase 1	Homo sapiens	43-48
32966473-2	2020	Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma.	Phosphatidylcholines	66-85	peroxisome proliferator activated receptor alpha	Mus musculus	170-179
32966473-2	2020	Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma.	Phosphatidylcholines	66-85	peroxisome proliferator activated receptor gamma	Mus musculus	180-189
32662451-5	2020	Distinction between normal control (NC) and acute beta-adrenergic receptor (beta-AR) activation-induced SCD groups was primarily due to the changes of diacylglycerols (DAG), phosphatidylcholine (PC), lysophosphatidylcholine (LysoPC) and sphingomyelin (SM) in positive mode.	Phosphatidylcholines	195-197	adrenergic receptor, beta 1	Mus musculus	76-83
32471727-0	2020	MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans.	Phosphatidylcholines	42-62	mitochondrial amidoxime reducing component 1	Homo sapiens	0-5
33083764-3	2020	Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs.	Phosphatidylcholines	113-132	fatty acid synthase	Homo sapiens	53-57
33083764-3	2020	Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs.	Phosphatidylcholines	134-136	fatty acid synthase	Homo sapiens	53-57
33083764-3	2020	Detailed lipid profiling revealed that inhibition of FASN resulted in significant reduction of sphingolipids and phosphatidylcholine (PC); moreover, we found that PC was the key metabolite for cell survival in hPSCs.	Phosphatidylcholines	163-165	fatty acid synthase	Homo sapiens	53-57
32705322-2	2020	In this study, the interaction between phloretin and human serum albumin (HSA) in an L-egg lecithin phosphatidylcholine (PC) liposome suspension was investigated by fluorescence and absorbance spectroscopy.	Phosphatidylcholines	121-123	albumin	Homo sapiens	59-72
32703435-2	2020	It is emerging that PCYT1A, a rate-limiting enzyme required for the biosynthesis of phosphatidylcholine, is associated with cancer progression.	Phosphatidylcholines	84-103	phosphate cytidylyltransferase 1A, choline	Homo sapiens	20-26
32666045-0	2020	Overactive EGF signaling promotes uv1 cell survival via increased phosphatidylcholine levels and suppression of SBP-1.	Phosphatidylcholines	66-85	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	11-14
32628014-11	2020	These results indicate that sphingomyelin and phosphatidylcholine lipids can act as charge-reducing agents when dissociated from native membrane protein-lipid complexes in the gas phase and provide a straightforward model to explain the results of several recent native mass spectrometry studies of protein-lipid complexes.	Phosphatidylcholines	46-65	gastrin	Homo sapiens	176-179
32304789-2	2020	Hence, chitosan nanoparticles (CS NPs), phosphatidylcholine and gentamicin were used to synthesize a novel nanodrug delivery system (GPC NPs).	Phosphatidylcholines	40-59	glycophorin C (Gerbich blood group)	Homo sapiens	133-136
32760418-5	2020	It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis.	Phosphatidylcholines	106-125	fatty acid desaturase 2	Arabidopsis thaliana	18-22
32760418-5	2020	It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis.	Phosphatidylcholines	106-125	fatty acid desaturase 2	Arabidopsis thaliana	24-47
32760418-5	2020	It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis.	Phosphatidylcholines	127-129	fatty acid desaturase 2	Arabidopsis thaliana	18-22
32760418-5	2020	It interacts with FAD2 (Fatty acid desaturase 2) and prevents accumulation of linolenic (18:3) containing phosphatidylcholine (PC) stimulating an increase of MGDG synthesis.	Phosphatidylcholines	127-129	fatty acid desaturase 2	Arabidopsis thaliana	24-47
31991038-5	2020	AtROD1 encodes phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), the enzyme that catalyzes a major flux of polyunsaturated fatty acids (PUFA) in oil synthesis.	Phosphatidylcholines	15-34	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	0-6
32694752-2	2020	Given the anti-inflammatory role of the cytokine IL-10, we investigated its modulatory effect on the production of oxidized phosphatidylcholines (OxPCs) as well as lipid metabolic responses in global myocardial ischemia/reperfusion (I/R) injury.	Phosphatidylcholines	124-144	interleukin 10	Homo sapiens	49-54
32708453-4	2020	Phosphatidylcholines (PC) and molecules of the sphingomyelin (SM) family exhibited the strongest anti-PAF effects, followed by phosphatidylethanolamines (PE).	Phosphatidylcholines	0-20	PCNA clamp associated factor	Homo sapiens	102-105
32708453-4	2020	Phosphatidylcholines (PC) and molecules of the sphingomyelin (SM) family exhibited the strongest anti-PAF effects, followed by phosphatidylethanolamines (PE).	Phosphatidylcholines	22-24	PCNA clamp associated factor	Homo sapiens	102-105
32708453-5	2020	PC contained higher amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and thus the lowest n-6/n-3 ratio.	Phosphatidylcholines	0-2	pumilio RNA binding family member 3	Homo sapiens	72-76
32708453-6	2020	Bioactive diacyl and alkyl-acyl PC and PE molecules bearing n-3 PUFA at their sn-2 position, especially docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA) but mostly oleic acid (OA), were identified in both PC and PE subclasses.	Phosphatidylcholines	32-34	pumilio RNA binding family member 3	Homo sapiens	64-68
32637097-9	2020	BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio.	Phosphatidylcholines	93-112	BTN1A1	Bos taurus	0-6
32637097-9	2020	BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio.	Phosphatidylcholines	114-116	BTN1A1	Bos taurus	0-6
32491269-0	2020	Testosterone replacement therapy in insulin-sensitive hypogonadal men restores phosphatidylcholine levels by regulation of arachidonic acid metabolism.	Phosphatidylcholines	79-98	insulin	Homo sapiens	36-43
32491269-3	2020	Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC).	Phosphatidylcholines	113-132	phospholipase A2 group IB	Homo sapiens	170-186
32491269-3	2020	Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC).	Phosphatidylcholines	134-136	phospholipase A2 group IB	Homo sapiens	170-186
32393038-2	2020	In our previous studies, we found that even a small amount of beta-sitosteryl sulfate (PSO4) significantly affects the phase behavior, hydration properties, and liposomal properties of pure saturated phosphatidylcholines (Kafle, et al, Colloids Surf.	Phosphatidylcholines	200-220	pre-mRNA processing factor 19	Homo sapiens	87-91
32582149-7	2020	This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC).	Phosphatidylcholines	140-159	phosphatidylethanolamine N-methyltransferase	Mus musculus	57-101
32582149-7	2020	This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC).	Phosphatidylcholines	140-159	phosphatidylethanolamine N-methyltransferase	Mus musculus	103-107
32582149-7	2020	This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC).	Phosphatidylcholines	161-163	phosphatidylethanolamine N-methyltransferase	Mus musculus	57-101
32582149-7	2020	This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC).	Phosphatidylcholines	161-163	phosphatidylethanolamine N-methyltransferase	Mus musculus	103-107
32521649-10	2020	Reduced MTHFR protein in the livers of FASD mothers and male pups resulted in choline/methyl metabolite disruptions in offspring liver (decreased betaine) and brain (decreased glycerophosphocholine and sphingomyelin in male pups, and decreased phosphatidylcholine in both sexes).	Phosphatidylcholines	244-263	methylenetetrahydrofolate reductase	Mus musculus	8-13
32625095-10	2020	The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups.	Phosphatidylcholines	155-174	interleukin 6	Rattus norvegicus	45-49
32625095-10	2020	The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups.	Phosphatidylcholines	155-174	tumor necrosis factor	Rattus norvegicus	50-59
32625095-10	2020	The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups.	Phosphatidylcholines	155-174	interleukin 6	Rattus norvegicus	233-237
32625095-10	2020	The correlational analysis between plasma of IL-6/TNF-alpha and metabolites suggested that acetylcholine, spermine, phenylalanine, threonine of plasma and phosphatidylcholine (36:4) of lung tissues were significantly associated with IL-6/TNF-alpha in CLP and CLP-ADMSCs groups.	Phosphatidylcholines	155-174	tumor necrosis factor	Rattus norvegicus	238-247
32393038-10	2020	Upon addition of PSO4, at room temperature, the PC fraction gradually converted into the liquid ordered (Lo) phase while the (PE + PA) fraction remained unaffected.	Phosphatidylcholines	48-50	pre-mRNA processing factor 19	Homo sapiens	17-21
32172343-4	2020	We established that ATP10B encodes a late endo-lysosomal lipid flippase that translocates the lipids glucosylceramide (GluCer) and phosphatidylcholine (PC) towards the cytosolic membrane leaflet.	Phosphatidylcholines	131-150	ATPase phospholipid transporting 10B (putative)	Homo sapiens	20-26
32172343-4	2020	We established that ATP10B encodes a late endo-lysosomal lipid flippase that translocates the lipids glucosylceramide (GluCer) and phosphatidylcholine (PC) towards the cytosolic membrane leaflet.	Phosphatidylcholines	152-154	ATPase phospholipid transporting 10B (putative)	Homo sapiens	20-26
31517566-2	2020	Using 13C-labeled choline and 13C-magnetic resonance spectroscopy and western blotting, we show increased de novo choline phospholipid (ChoPL) production and activation of PCYT1A (phosphate cytidylyltransferase 1, choline, alpha), the rate-limiting enzyme of phosphatidylcholine (PtdCho) synthesis, during autophagy.	Phosphatidylcholines	259-278	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	172-178
31517566-2	2020	Using 13C-labeled choline and 13C-magnetic resonance spectroscopy and western blotting, we show increased de novo choline phospholipid (ChoPL) production and activation of PCYT1A (phosphate cytidylyltransferase 1, choline, alpha), the rate-limiting enzyme of phosphatidylcholine (PtdCho) synthesis, during autophagy.	Phosphatidylcholines	280-286	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	172-178
32107839-6	2020	Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals.	Phosphatidylcholines	135-154	phospholipase A2 group IVB	Homo sapiens	46-53
32316172-0	2020	Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia.	Phosphatidylcholines	94-114	NUT midline carcinoma, family member 1	Mus musculus	6-9
32084434-2	2020	LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2).	Phosphatidylcholines	36-55	phospholipase A2 group IB	Homo sapiens	59-75
32084434-2	2020	LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2).	Phosphatidylcholines	36-55	phospholipase A2 group IB	Homo sapiens	77-81
32253242-5	2020	As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry.	Phosphatidylcholines	95-114	apolipoprotein E	Homo sapiens	38-42
32253242-5	2020	As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry.	Phosphatidylcholines	95-114	apolipoprotein E	Homo sapiens	85-89
32253242-5	2020	As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry.	Phosphatidylcholines	95-114	apolipoprotein E	Homo sapiens	85-89
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	104-123	phosphate cytidylyltransferase 1A, choline	Homo sapiens	0-45
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	104-123	phosphate cytidylyltransferase 1A, choline	Homo sapiens	47-55
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	104-123	phosphate cytidylyltransferase 1B, choline	Homo sapiens	61-68
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	125-127	phosphate cytidylyltransferase 1A, choline	Homo sapiens	0-45
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	125-127	phosphate cytidylyltransferase 1A, choline	Homo sapiens	47-55
32186954-1	2020	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	125-127	phosphate cytidylyltransferase 1B, choline	Homo sapiens	61-68
32176333-4	2020	NPC6 is associated with the chloroplasts and microsomal membranes, and hydrolyzes phosphatidylcholine and galactolipids to produce diacylglycerol.	Phosphatidylcholines	82-101	non-specific phospholipase C6	Arabidopsis thaliana	0-4
32287294-8	2020	In a cell line representing HER2-overexpressing tumor subtype an elevated expression of TG (<= C-46), phosphatidylcholines (PC) and PE containing short-chained (<= C-16) saturated or monounsaturated fatty acids were observed.	Phosphatidylcholines	102-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32
32287294-8	2020	In a cell line representing HER2-overexpressing tumor subtype an elevated expression of TG (<= C-46), phosphatidylcholines (PC) and PE containing short-chained (<= C-16) saturated or monounsaturated fatty acids were observed.	Phosphatidylcholines	124-126	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32
32107839-6	2020	Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals.	Phosphatidylcholines	135-154	arachidonate 15-lipoxygenase type B	Homo sapiens	58-65
32107839-6	2020	Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals.	Phosphatidylcholines	223-242	phospholipase A2 group IVB	Homo sapiens	46-53
32107839-6	2020	Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals.	Phosphatidylcholines	223-242	arachidonate 15-lipoxygenase type B	Homo sapiens	58-65
32234213-5	2020	In addition to allosterically activating IQSec1, ORP3 also extracts PI4P from the PM, in exchange for phosphatidylcholine.	Phosphatidylcholines	102-121	IQ motif and Sec7 domain ArfGEF 1	Homo sapiens	41-47
32055910-10	2020	Upon stimulation, diacylglycerides, hexosylceramides, phosphatidylcholines, phosphoethanolamines, and lysophosphoethanolamines were upregulated in CD4+ cells and PMNs, whereas CD14+ cells did not show significant changes.	Phosphatidylcholines	54-74	CD4 molecule	Homo sapiens	147-150
32234213-5	2020	In addition to allosterically activating IQSec1, ORP3 also extracts PI4P from the PM, in exchange for phosphatidylcholine.	Phosphatidylcholines	102-121	oxysterol binding protein like 3	Homo sapiens	49-53
31757360-6	2020	First, a computational modeling approach by coarse-grained molecular dynamics simulation of the whole TRPV1 embedded in a phosphatidylcholine and phosphatidylethanolamine membrane provides insight into the dynamics of this channel domain.	Phosphatidylcholines	122-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
32008771-13	2020	The changes observed in muscle lysophosphatidylcholine and phosphatidylcholine concentrations may point to an alteration in phosphatidylcholine metabolism, probably resulting in an increase in membrane stiffness, which may lead to abnormalities in insulin signaling in the muscle of over-conditioned cows.	Phosphatidylcholines	59-78	insulin	Bos taurus	248-255
32198492-1	2020	The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer.	Phosphatidylcholines	66-85	phospholipase D1	Homo sapiens	31-47
32198492-1	2020	The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer.	Phosphatidylcholines	66-85	phospholipase D1	Homo sapiens	49-53
30389273-7	2020	Rhodioloside administration showed atheroprotective effects on the apoE-/- mice with regulating the levels of 1 phosphatidylcholine, 2 phosphatidylserines, 5 alkyldiacylglycerols and 3 alkenyldiacylglycerols back to normal.	Phosphatidylcholines	112-131	apolipoprotein E	Mus musculus	67-71
31355949-2	2020	Previous studies identified phosphatidylcholines as potential endogenous agonist ligands for LRH-1.	Phosphatidylcholines	28-48	nuclear receptor subfamily 5, group A, member 2	Mus musculus	93-98
31355949-3	2020	In the liver, distinct subsets of phosphatidylcholine species are generated by two different pathways: choline addition to phosphatidic acid through the Kennedy pathway and trimethylation of phosphatidylethanolamine through phosphatidylethanolamine N-methyl transferase (PEMT).	Phosphatidylcholines	34-53	phosphatidylethanolamine N-methyltransferase	Mus musculus	224-269
31355949-3	2020	In the liver, distinct subsets of phosphatidylcholine species are generated by two different pathways: choline addition to phosphatidic acid through the Kennedy pathway and trimethylation of phosphatidylethanolamine through phosphatidylethanolamine N-methyl transferase (PEMT).	Phosphatidylcholines	34-53	phosphatidylethanolamine N-methyltransferase	Mus musculus	271-275
31355949-6	2020	In contrast, activation of LRH-1 by its phosphatidylcholine agonists exerts opposite effects.	Phosphatidylcholines	40-59	nuclear receptor subfamily 5, group A, member 2	Mus musculus	27-32
32121031-2	2020	To perform the assay, an aliquot of a PLD standard solution is typically added to borate buffer containing phosphatidylcholine at a certain concentration and the oxidation current of hydrogen peroxide is then measured at the rotating modified electrode by applying a detection potential of +&nbsp;0.7 V vs. SCE.	Phosphatidylcholines	107-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	38-41
32198481-4	2020	The hNM lipid extract was composed of a complex mixture of phospholipids, with high amounts of phosphatidylcholines, phosphatidylinositols (PI) and cholesterol.	Phosphatidylcholines	95-115	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	4-7
32020064-7	2020	Furthermore, several altered peaks on mass spectra were identified as phosphatidylcholine species in TGF-beta-stimulated HNSCC cells.	Phosphatidylcholines	70-89	transforming growth factor alpha	Homo sapiens	101-109
31864675-7	2020	The proliferation and differentiation levels of osteoprogenetor cells were enhanced and ALP was strongly expressed in the groups grafted with phosphatidylcholine and COL I.	Phosphatidylcholines	142-161	alkaline phosphatase, placental	Homo sapiens	88-91
32071354-0	2020	The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts.	Phosphatidylcholines	4-23	START domain containing 7	Mus musculus	41-47
32071354-1	2020	StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration.	Phosphatidylcholines	12-31	START domain containing 7	Mus musculus	0-6
32071354-1	2020	StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration.	Phosphatidylcholines	33-35	START domain containing 7	Mus musculus	0-6
32071354-1	2020	StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration.	Phosphatidylcholines	116-118	START domain containing 7	Mus musculus	0-6
32071354-7	2020	The reduction in mitochondrial PC levels and oxygen consumption rates, decreased expression of myomaker, myomerger and PGC-1alpha, as well as impaired myogenic differentiation, were completely restored when the protein was reintroduced into StarD7-knockout C2C12 cells.	Phosphatidylcholines	31-33	START domain containing 7	Mus musculus	241-247
31647997-1	2020	Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature.	Phosphatidylcholines	169-188	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	0-8
31647997-1	2020	Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature.	Phosphatidylcholines	169-188	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	34-37
31647997-1	2020	Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature.	Phosphatidylcholines	190-192	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	0-8
31647997-1	2020	Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature.	Phosphatidylcholines	190-192	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	34-37
31739040-6	2020	Both enzymes have improved thermostability compared to mammalian pancreatic sPLA2 since they are active and stable at 55  C, with specific activities of 320 and 190 U mg-1 measured on phosphatidylcholine, respectively.	Phosphatidylcholines	184-203	phospholipase A2 group IIA	Homo sapiens	76-81
32082314-10	2020	Administration of colony stimulating factor 2 (CSF-2), a critical factor in AM development and maintenance, increased AM numbers in CD44-/- mice and decreased phosphatidylcholine levels in the bronchoalveolar lavage, but was unable to decrease intracellular lipid accumulation in CD44-/- AMs.	Phosphatidylcholines	159-178	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	18-45
32082314-10	2020	Administration of colony stimulating factor 2 (CSF-2), a critical factor in AM development and maintenance, increased AM numbers in CD44-/- mice and decreased phosphatidylcholine levels in the bronchoalveolar lavage, but was unable to decrease intracellular lipid accumulation in CD44-/- AMs.	Phosphatidylcholines	159-178	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	47-52
31826940-5	2020	Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells.	Phosphatidylcholines	71-90	TNF receptor-associated factor 3	Mus musculus	129-134
31770533-13	2020	Furthermore, transformation from choline to phosphatidylcholine regulated by miR-106a-5p was also disrupted, resulting in phosphatidic choline synthesis disorder and reduced cell membrane synthesis.	Phosphatidylcholines	44-63	microRNA 106a	Homo sapiens	77-85
31826940-5	2020	Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells.	Phosphatidylcholines	71-90	TNF receptor-associated factor 3	Mus musculus	170-175
31826940-7	2020	Taken together, our results indicate that enhanced phosphocholine and phosphatidylcholine synthesis supports the prolonged survival of Traf3 -/- B lymphocytes.	Phosphatidylcholines	70-89	TNF receptor associated factor 3	Homo sapiens	135-140
31678520-4	2020	Most transferosomes contain phosphatidylcholine (C18) as it is the most abundant lipid component of the cell membrane, and hence, it is highly tolerated for the skin, decreasing the risk of undesirable effects, such as hypersensitive reactions.	Phosphatidylcholines	28-47	Bardet-Biedl syndrome 9	Homo sapiens	49-52
31873305-1	2020	ABCB4 is an ATP-binding cassette transporter that extrudes phosphatidylcholine into the bile canaliculi of the liver.	Phosphatidylcholines	59-78	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
31541319-3	2020	One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline.	Phosphatidylcholines	66-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44
31541319-3	2020	One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline.	Phosphatidylcholines	66-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
31918922-1	2020	OBJECTIVE: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis.	Phosphatidylcholines	71-90	phosphatidylethanolamine N-methyltransferase	Mus musculus	55-59
31918922-1	2020	OBJECTIVE: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis.	Phosphatidylcholines	92-94	phosphatidylethanolamine N-methyltransferase	Mus musculus	55-59
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	39-58	phospholipase D1	Homo sapiens	0-4
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	39-58	phospholipase D2	Homo sapiens	9-13
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	60-62	phospholipase D1	Homo sapiens	0-4
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	60-62	phospholipase D2	Homo sapiens	9-13
31836711-1	2019	Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare monogenic disease caused by mutations in the ABCB4 gene, resulting in a reduction in biliary phosphatidylcholine.	Phosphatidylcholines	164-183	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	116-121
33132268-3	2020	We have previously reported that phosphatidylcholine (PC), the predominant bile phospholipid, protects hepatocytes from the cytotoxicity of bile salts, whereas cholesterol reverses the cytoprotective effects of PC against bile salts.	Phosphatidylcholines	33-52	pyruvate carboxylase	Mus musculus	54-56
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Phosphatidylcholines	203-222	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Phosphatidylcholines	203-222	ATP binding cassette subfamily B member 4	Homo sapiens	149-154
31815960-13	2019	Our study suggests that DENV regulates aminophospholipids, especially phosphatidylcholine and phosphatidylethanolamine, by inhibiting AGPAT1 expression to increase aminophospholipid availability for virus multiplication.	Phosphatidylcholines	70-89	1-acylglycerol-3-phosphate O-acyltransferase 1	Homo sapiens	134-140
31835418-1	2019	: Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC).	Phosphatidylcholines	108-127	patatin like phospholipase domain containing 6	Homo sapiens	2-28
31835418-1	2019	: Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC).	Phosphatidylcholines	108-127	patatin like phospholipase domain containing 6	Homo sapiens	30-33
31835418-1	2019	: Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC).	Phosphatidylcholines	129-131	patatin like phospholipase domain containing 6	Homo sapiens	2-28
31835418-1	2019	: Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC).	Phosphatidylcholines	129-131	patatin like phospholipase domain containing 6	Homo sapiens	30-33
31844833-9	2019	Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis.	Phosphatidylcholines	21-23	acyl-CoA binding protein 4	Arabidopsis thaliana	39-46
31844833-9	2019	Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis.	Phosphatidylcholines	21-23	acyl-CoA binding protein 5	Arabidopsis thaliana	46-53
31844833-9	2019	Interestingly, when LPC composition in atacbp4atacbp5 was compared with atacbp4 and atacbp5, significant differences were observed between atacbp4atacbp5 and each single mutant, implying that AtACBP4 and AtACBP5 play combinatory roles by affecting LPC (but not PC) biosynthesis.	Phosphatidylcholines	21-23	acyl-CoA binding protein 4	Arabidopsis thaliana	192-199
31844833-10	2019	Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds.	Phosphatidylcholines	13-15	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	105-111
31844833-10	2019	Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds.	Phosphatidylcholines	13-15	phospholipase A 2A	Arabidopsis thaliana	117-139
31844833-10	2019	Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds.	Phosphatidylcholines	13-15	phospholipase A 2A	Arabidopsis thaliana	141-150
31844833-10	2019	Furthermore, PC-related genes such as those encoding acyl-CoA:lysophphosphatidylcholine acyltransferase (LPCAT1) and phospholipase A2 alpha (PLA2alpha) were upregulated in atacbp6 developing seeds.	Phosphatidylcholines	13-15	acyl-CoA-binding protein 6	Arabidopsis thaliana	172-179
31665653-8	2019	Brain-derived neurotrophic factor was increased by di-DHA PC and DHA-LPC, but not by TAG-DHA, showing that enrichment of brain DHA correlated with its functional effect.	Phosphatidylcholines	58-60	brain-derived neurotrophic factor	Rattus norvegicus	0-33
31348857-4	2019	Our results reveal that the PC lipids could attach to the PEO either as vesicles or as bilayers, depending on whether they were above or below TM.	Phosphatidylcholines	28-30	twinkle mtDNA helicase	Homo sapiens	58-61
31578786-8	2019	The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC.	Phosphatidylcholines	153-155	C-X-C motif chemokine ligand 8	Homo sapiens	44-62
31578786-8	2019	The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC.	Phosphatidylcholines	153-155	interleukin 6	Homo sapiens	64-68
31681760-6	2019	In particular, NSM2 ablation resulted in increase of lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) which both govern PM biophysical properties.	Phosphatidylcholines	58-77	sphingomyelin phosphodiesterase 3	Homo sapiens	15-19
31726375-4	2019	Using this structural data, computational docking simulation predicted the putative binding sites for phosphatidylcholine (PC), an endogenous ligand that interacts with FT to modulate flowering time.	Phosphatidylcholines	102-121	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	169-171
31717561-6	2019	In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects.	Phosphatidylcholines	105-124	apolipoprotein E	Homo sapiens	185-189
31717561-6	2019	In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects.	Phosphatidylcholines	126-128	apolipoprotein E	Homo sapiens	185-189
31376475-6	2019	BMDMs from ACSL4-deficient mice also showed a reduced incorporation of HUFA into phosphatidylcholines.	Phosphatidylcholines	81-101	acyl-CoA synthetase long-chain family member 4	Mus musculus	11-16
31726375-4	2019	Using this structural data, computational docking simulation predicted the putative binding sites for phosphatidylcholine (PC), an endogenous ligand that interacts with FT to modulate flowering time.	Phosphatidylcholines	123-125	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	169-171
31726375-6	2019	In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function.	Phosphatidylcholines	121-123	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	29-31
31726375-6	2019	In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function.	Phosphatidylcholines	121-123	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	64-66
31726375-6	2019	In planta, one of the mutant FT proteins significantly affected FT function in flowering, emphasizing the involvement of PC binding in modulating FT function.	Phosphatidylcholines	121-123	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	64-66
31726375-7	2019	Our structural, biochemical, and transgenic analyses reveal the molecular mechanism of PC binding in FT-mediated flowering time control.	Phosphatidylcholines	87-89	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	101-103
31439667-10	2019	Overexpression of the AtCCT1 catalytic domain in Nicotiana benthamiana leaves increased PC content, and SnRK1 co-expression reduced this effect.	Phosphatidylcholines	88-90	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	22-28
31667320-2	2019	In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC).	Phosphatidylcholines	135-167	tumor necrosis factor	Homo sapiens	44-71
31667320-2	2019	In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC).	Phosphatidylcholines	135-167	tumor necrosis factor	Homo sapiens	73-81
31667320-2	2019	In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC).	Phosphatidylcholines	169-171	tumor necrosis factor	Homo sapiens	44-71
31667320-2	2019	In the article alluded to, we reported that tumor necrosis factor alpha (TNFalpha) increases notably the cellular content of the major glycerolipid phosphatidylcholine (PC).	Phosphatidylcholines	169-171	tumor necrosis factor	Homo sapiens	73-81
31233884-2	2019	Loss of SWS in Drosophila also causes locomotion deficits, age-dependent neurodegeneration, and an increase in lysophosphatidylcholine (LPC) and phosphatidylcholine (PC).	Phosphatidylcholines	115-134	swiss cheese	Drosophila melanogaster	8-11
31176036-7	2019	We also showed that the PC efflux from ABCB4-expressing HEK293 cells was stimulated by taurohyodeoxycholate much more strongly than the other tested bile salts.	Phosphatidylcholines	24-26	ATP binding cassette subfamily B member 4	Homo sapiens	39-44
31176036-10	2019	Therefore, the enhancing effect of taurohyodeoxycholate on the ABCB4-mediated PC efflux may be due to the strong mixed micelle formation ability.	Phosphatidylcholines	78-80	ATP binding cassette subfamily B member 4	Homo sapiens	63-68
31284753-1	2019	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-49
31284753-1	2019	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	51-55
31284753-1	2019	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-49
31284753-1	2019	Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ~30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	51-55
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	141-160	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	126-131
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	141-160	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	179-184
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	141-160	ATP binding cassette subfamily B member 4	Homo sapiens	234-239
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	162-164	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	126-131
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	162-164	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	179-184
31176036-3	2019	In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4.	Phosphatidylcholines	162-164	ATP binding cassette subfamily B member 4	Homo sapiens	234-239
31199045-0	2019	Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.	Phosphatidylcholines	12-31	glycine N-methyltransferase	Homo sapiens	90-117
31199045-2	2019	Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear.	Phosphatidylcholines	106-108	phosphatidylethanolamine N-methyltransferase	Homo sapiens	34-78
31199045-2	2019	Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear.	Phosphatidylcholines	106-108	phosphatidylethanolamine N-methyltransferase	Homo sapiens	80-84
31199045-2	2019	Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear.	Phosphatidylcholines	176-178	phosphatidylethanolamine N-methyltransferase	Homo sapiens	34-78
31199045-2	2019	Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme synthesizing PC has been associated with disease, the functional mechanism linking PC metabolism to the pathogenesis of non-alcoholic steatohepatitis (NASH) remains unclear.	Phosphatidylcholines	176-178	phosphatidylethanolamine N-methyltransferase	Homo sapiens	80-84
31233884-2	2019	Loss of SWS in Drosophila also causes locomotion deficits, age-dependent neurodegeneration, and an increase in lysophosphatidylcholine (LPC) and phosphatidylcholine (PC).	Phosphatidylcholines	137-139	swiss cheese	Drosophila melanogaster	8-11
31515451-6	2019	Unbiased atomistic MD simulations with 1.4 mol% PI(4,5)P2 in a phosphatidylcholine bilayer identified 8 binding sites with significant probability of binding PI(4,5)P2 Three of these sites captured 85% of all ANO1-PI(4,5)P2 interactions.	Phosphatidylcholines	63-82	anoctamin 1	Homo sapiens	209-213
31608287-8	2019	Furthermore, the DQ alpha-1, DQ beta-1 and p24 transmembrane helical domains were reconstituted into POPC or POPC/SM-C18 lipid bilayers where the fatty acyl chain of either the phosphatidylcholine or of the sphingolipid have been deuterated.	Phosphatidylcholines	177-196	transmembrane p24 trafficking protein 2	Homo sapiens	43-46
30730833-3	2019	Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes.	Phosphatidylcholines	70-89	ATP binding cassette subfamily B member 4	Homo sapiens	26-31
30730833-3	2019	Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes.	Phosphatidylcholines	91-93	ATP binding cassette subfamily B member 4	Homo sapiens	26-31
30730833-4	2019	ABCB4 deficiency can result in altered PC to bile salt ratios, which led to intrahepatic cholestasis of pregnancy, low phospholipid associated cholelithiasis, drug induced liver injury or even progressive familial intrahepatic cholestasis type 3.	Phosphatidylcholines	39-41	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
31538486-3	2019	ABCB4 encodes for a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile.	Phosphatidylcholines	107-126	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
31480447-4	2019	Sphingomyelin synthase (SMS) is the enzyme that transfers a phosphatidylcholine to ceramide to generate sphingomyelin.	Phosphatidylcholines	60-79	spermine synthase	Homo sapiens	0-22
31616255-10	2019	In the retina, ELOVL4 is expressed exclusively in photoreceptors and produces VLC-PUFA that are incorporated into phosphatidylcholine and enriched in the light sensitive membrane disks of the photoreceptor outer segments.	Phosphatidylcholines	114-133	ELOVL fatty acid elongase 4	Homo sapiens	15-21
31616255-10	2019	In the retina, ELOVL4 is expressed exclusively in photoreceptors and produces VLC-PUFA that are incorporated into phosphatidylcholine and enriched in the light sensitive membrane disks of the photoreceptor outer segments.	Phosphatidylcholines	114-133	pumilio RNA binding family member 3	Homo sapiens	82-86
31488158-0	2019	Phosphatidylcholine and its relation to apolipoproteins A-1 and B changes after Roux-en-Y gastric bypass: a cohort study.	Phosphatidylcholines	0-19	apolipoprotein A1	Homo sapiens	40-65
31488158-2	2019	We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio.	Phosphatidylcholines	27-29	apolipoprotein A1	Homo sapiens	247-253
31303424-5	2019	Growth factor receptor-driven cancers are found to depend on LPCAT1 to shape plasma membrane composition through enhanced saturated phosphatidylcholine content that is, in turn, required for the transduction of oncogenic signals.	Phosphatidylcholines	132-151	lysophosphatidylcholine acyltransferase 1	Homo sapiens	61-67
31565053-8	2019	Lower inflammatory cell infiltration in the ileum improved intestinal histology, and reduced serum DAO levels were observed in PC-treated cirrhotic rats.	Phosphatidylcholines	127-129	amine oxidase, copper containing 1	Rattus norvegicus	99-102
29527950-7	2019	Therefore, incorporation of BdE into phosphatidylcholine-cholesterol liposomes improves its anti-inflammatory effect.	Phosphatidylcholines	37-56	homeobox D13	Homo sapiens	28-31
31488158-2	2019	We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio.	Phosphatidylcholines	27-29	apolipoprotein B	Homo sapiens	255-260
31488158-2	2019	We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio.	Phosphatidylcholines	27-29	apolipoprotein B	Homo sapiens	265-270
31488158-2	2019	We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio.	Phosphatidylcholines	27-29	apolipoprotein A1	Homo sapiens	271-277
31062097-6	2019	Regarding the associations between the metabolites and z-BMI, phospholipids, especially those containing polyunsaturated fatty acids, were the species most impacted by the maternal metabolic status, since numerous phosphatidylcholines-PUFA were positively associated with z-BMI in NW but negatively in OV/OB and GDM groups at birth.	Phosphatidylcholines	214-234	pumilio RNA binding family member 3	Homo sapiens	235-239
31301838-15	2019	Overall, enhanced supply of choline during NEB increases hepatic activity of BHMT and MTR to regenerate methionine and PC, partly to help clear TAG.	Phosphatidylcholines	119-121	betaine--homocysteine S-methyltransferase	Bos taurus	77-81
31480447-4	2019	Sphingomyelin synthase (SMS) is the enzyme that transfers a phosphatidylcholine to ceramide to generate sphingomyelin.	Phosphatidylcholines	60-79	spermine synthase	Homo sapiens	24-27
31450691-3	2019	Multilamellar liposomes made of natural phosphatidylcholine were used for the incorporation of a mixture of somatostatin and sorbitol dissolved in citrate buffer at pH = 5.	Phosphatidylcholines	40-59	somatostatin	Homo sapiens	108-120
31380624-0	2019	Impact of Cardiolipin and Phosphatidylcholine Interactions on the Conformational Ensemble of Cytochrome c.	Phosphatidylcholines	26-45	cytochrome c, somatic	Homo sapiens	93-105
31380624-2	2019	In this work, we study the conformational dynamics of Cyt c in the presence of CL and phosphatidylcholine (PC) phospholipids also present in the mitochondrial membrane to better understand how these interactions might drive transformation to the peroxidase-active protein.	Phosphatidylcholines	86-105	cytochrome c, somatic	Homo sapiens	54-59
31380624-2	2019	In this work, we study the conformational dynamics of Cyt c in the presence of CL and phosphatidylcholine (PC) phospholipids also present in the mitochondrial membrane to better understand how these interactions might drive transformation to the peroxidase-active protein.	Phosphatidylcholines	107-109	cytochrome c, somatic	Homo sapiens	54-59
31434800-6	2019	We conclude that human PNPLA3-I148M is a loss-of-function allele that remodels liver TGs in a polyunsaturated direction by impairing hydrolysis/transacylation of PUFAs from DAGs to feed phosphatidylcholine synthesis.	Phosphatidylcholines	186-205	patatin like phospholipase domain containing 3	Homo sapiens	23-29
31418690-4	2019	Macrophage-specific knockout of phosphocholine cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway, alleviated obesity-induced WAT inflammation and insulin resistance.	Phosphatidylcholines	118-120	phosphate cytidylyltransferase 1A, choline	Homo sapiens	71-79
31311871-6	2019	Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine.	Phosphatidylcholines	245-264	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	166-169
30653260-1	2019	Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL).	Phosphatidylcholines	110-129	lipase G, endothelial type	Homo sapiens	0-18
30653260-1	2019	Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL).	Phosphatidylcholines	110-129	lipase G, endothelial type	Homo sapiens	20-24
31216357-3	2019	The disease is caused by loss of function mutations in the choline kinase beta (CHKB) gene which results in dysfunction of the Kennedy pathway for the synthesis of phosphatidylcholine.	Phosphatidylcholines	164-183	choline kinase beta	Mus musculus	59-78
31216357-3	2019	The disease is caused by loss of function mutations in the choline kinase beta (CHKB) gene which results in dysfunction of the Kennedy pathway for the synthesis of phosphatidylcholine.	Phosphatidylcholines	164-183	choline kinase beta	Mus musculus	80-84
31273804-1	2019	Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells.	Phosphatidylcholines	4-23	phospholipase A2 group IB	Homo sapiens	63-79
31273804-1	2019	Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells.	Phosphatidylcholines	29-35	phospholipase A2 group IB	Homo sapiens	63-79
31221730-4	2019	Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1.	Phosphatidylcholines	51-70	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	82-122
31221730-4	2019	Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1.	Phosphatidylcholines	51-70	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	128-156
31221730-4	2019	Expression of genes important for the formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OLEATE DESATURATION1 were strongly upregulated, consistent with increased substrate supply for PDAT1.	Phosphatidylcholines	51-70	phospholipid:diacylglycerol acyltransferase	Arabidopsis thaliana	231-236
31311871-6	2019	Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine.	Phosphatidylcholines	245-264	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	222-225
31379987-0	2019	Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity in Caenorhabditis elegans.	Phosphatidylcholines	0-19	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	41-47
31379987-9	2019	Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine.	Phosphatidylcholines	151-170	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	71-79
31379987-9	2019	Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine.	Phosphatidylcholines	151-170	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	84-89
31379987-10	2019	DAF-16, a transcription factor modulating stress response genes, was accumulated in the nucleus by phosphatidylcholine treatment.	Phosphatidylcholines	99-118	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	0-6
31379987-13	2019	Experiments with long-lived mutants revealed that the lifespan-extending effect of phosphatidylcholine specifically overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16.	Phosphatidylcholines	83-102	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	190-196
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	41-60	protoporphyrinogen oxidase	Homo sapiens	145-148
30953761-8	2019	The silencing of CCTalpha, the key enzyme in PC synthesis, prevents SFA-mediated NLRP3 activation, demonstrating the essential role of the de novo PC synthesis.	Phosphatidylcholines	45-47	t-complex 1	Homo sapiens	17-25
30877512-2	2019	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
30877512-2	2019	Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
31306056-5	2019	RESULTS: We identified an association with relative phosphatidylcholine 38:3 (%PC 38:3) concentration, which was replicated in the ORCADES (Orkney Complex Disease Study; n=951), with a pooled association across studies of 2.59 (95% CI, 1.3-3.9; P=1.1x10-4) ms PWD per mol% increase.	Phosphatidylcholines	52-71	ATPase copper transporting beta	Homo sapiens	260-263
31181753-1	2019	Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs).	Phosphatidylcholines	156-176	chromatin assembly factor 1 subunit A	Homo sapiens	40-44
31181753-1	2019	Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs).	Phosphatidylcholines	178-181	chromatin assembly factor 1 subunit A	Homo sapiens	40-44
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	41-60	protoporphyrinogen oxidase	Homo sapiens	153-156
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	41-60	protoporphyrinogen oxidase	Homo sapiens	153-156
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	62-66	protoporphyrinogen oxidase	Homo sapiens	145-148
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	62-66	protoporphyrinogen oxidase	Homo sapiens	153-156
31117745-2	2019	Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and bilayer curvature affects the binding of several PPO-PEO-PPO triblocks with varying PPO content and a tPPO-PEO diblock, where t refers to a tert-butyl end group.	Phosphatidylcholines	62-66	protoporphyrinogen oxidase	Homo sapiens	153-156
31086211-3	2019	The aim of the present study was to elucidate the respective importance of Chol and SM as compared to phosphatidylcholine (PC) species in the membrane-related effects of Rh2.	Phosphatidylcholines	102-121	Rh associated glycoprotein	Homo sapiens	170-173
30753691-5	2019	Based on combined analyses of gene expression, JA biosynthesis and glycerolipid remodeling in wild-type Arabidopsis and in the coi1-16 mutant, JA signaling seems important in the determination of the basal levels of phosphatidylcholine, phosphatidic acid (PA), monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol.	Phosphatidylcholines	216-235	RNI-like superfamily protein	Arabidopsis thaliana	127-134
30220058-8	2019	Through the use of specific inhibitors targeting each of the known physiological pathways of choline, synthesis of phosphatidylcholine from choline was found to be essential in bringing about the changes seen in the choline-supplemented MeCP2-knockdown neurons.	Phosphatidylcholines	115-134	methyl CpG binding protein 2	Mus musculus	237-242
31086211-3	2019	The aim of the present study was to elucidate the respective importance of Chol and SM as compared to phosphatidylcholine (PC) species in the membrane-related effects of Rh2.	Phosphatidylcholines	123-125	Rh associated glycoprotein	Homo sapiens	170-173
30932478-6	2019	Results show the distribution of some identified molecular ions of the EGFR inhibitor erlotinib, a phosphatidylcholine lipid, and cholesterol, which were reconstructed in 3D and mapped to the MRI space.	Phosphatidylcholines	99-118	epidermal growth factor receptor	Mus musculus	71-75
31249646-4	2019	Analysis of the lipid metabolic profiles at young adult and ten-day-old ages among wild-type N2, glp-1 defective mutant, and double mutant daf-16;glp-1 uncovered significant age-related differences in the total amount of phosphatidylcholines (PC), sphingomyelins (SM), ceramides (Cer), diglycerides (DG), and triglycerides (TG).	Phosphatidylcholines	221-241	glp-1/Notch intracellular domain	Caenorhabditis elegans	146-151
31050338-2	2019	Structural insights into the cPLA2alpha preference for phosphatidylcholine (PC)-enriched membranes have remained elusive.	Phosphatidylcholines	55-74	phospholipase A2 group IVA	Homo sapiens	29-39
31050338-2	2019	Structural insights into the cPLA2alpha preference for phosphatidylcholine (PC)-enriched membranes have remained elusive.	Phosphatidylcholines	76-78	phospholipase A2 group IVA	Homo sapiens	29-39
31050338-7	2019	Mutagenesis analyses confirm that Tyr96 and Asn65 function in PC binding selectivity by the C2-domain and in the regulation of cPLA2alpha activity.	Phosphatidylcholines	62-64	phospholipase A2 group IVA	Homo sapiens	127-137
30222019-2	2019	MDR3 mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile.	Phosphatidylcholines	35-54	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
30837243-4	2019	Specifically, stroma-derived lysophosphatidylcholines support PDAC cell synthesis of phosphatidylcholines, key components of cell membranes, and also facilitate production of the potent wound-healing mediator lysophosphatidic acid (LPA) by the extracellular enzyme autotaxin, which is overexpressed in PDAC.	Phosphatidylcholines	33-53	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	265-274
31040306-1	2019	Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of hepatocytes.	Phosphatidylcholines	104-123	ATP binding cassette subfamily B member 4	Homo sapiens	75-80
30790612-2	2019	In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity.	Phosphatidylcholines	42-61	insulin	Homo sapiens	15-22
30958839-12	2019	Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling.	Phosphatidylcholines	45-48	tumor necrosis factor	Mus musculus	15-23
30958839-12	2019	Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling.	Phosphatidylcholines	45-48	interleukin 1 alpha	Mus musculus	27-35
30958839-12	2019	Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling.	Phosphatidylcholines	45-48	tumor necrosis factor	Mus musculus	188-196
30958839-12	2019	Suppression of TNFalpha or IL-1beta reversed PPC-induced lipolysis and apoptosis in 3T3-L1 adipocytes, suggesting that PPC could promote adipocyte-specific lipolysis and apoptosis through TNFalpha and IL-1beta-mediated signaling.	Phosphatidylcholines	45-48	interleukin 1 alpha	Mus musculus	201-209
31788037-3	2019	To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles.	Phosphatidylcholines	47-49	phospholipase A2 group IB	Homo sapiens	53-57
31788037-3	2019	To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles.	Phosphatidylcholines	139-141	phospholipase A2 group IB	Homo sapiens	53-57
31788037-4	2019	Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC).	Phosphatidylcholines	149-151	phospholipase A2 group IB	Homo sapiens	164-180
31788037-4	2019	Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC).	Phosphatidylcholines	149-151	phospholipase A2 group IVA	Homo sapiens	182-192
31788037-4	2019	Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC).	Phosphatidylcholines	246-248	phospholipase A2 group IB	Homo sapiens	164-180
31788037-4	2019	Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC).	Phosphatidylcholines	246-248	phospholipase A2 group IVA	Homo sapiens	182-192
31788037-6	2019	Finally, genetic validation for the specificity of the method consisted of the downregulation of two biosynthetic enzymes responsible for the production of PE and PC, choline kinase A (CHKA) and ethanolamine kinase 1 (ETNK1).	Phosphatidylcholines	163-165	choline kinase alpha	Homo sapiens	185-189
31788037-7	2019	This new UPLC ESI-MS/MS method provides accurate and highly sensitive detection of PE and PC species containing AA and DHA allowing for the specific examination of the substrate utilization of these phospholipids by PLA2 in vitro and in cells.	Phosphatidylcholines	90-92	phospholipase A2 group IB	Homo sapiens	216-220
30790612-2	2019	In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity.	Phosphatidylcholines	42-61	surfactant protein C	Rattus norvegicus	63-66
30790612-2	2019	In this study, insulin was complexed with phosphatidylcholine (SPC) to form an insulin-SPC complex (ins-SPC) with increased lipophilicity.	Phosphatidylcholines	42-61	surfactant protein C	Rattus norvegicus	87-90
30911014-7	2019	In this work, we demonstrate that EB-3D and EB-3P interfere with phosphatidylcholine biosynthesis via both CDP-choline pathway and choline uptake by the cell.	Phosphatidylcholines	65-84	natriuretic peptide A	Homo sapiens	107-110
30773008-0	2019	Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry.	Phosphatidylcholines	25-45	TOR signaling pathway regulator	Homo sapiens	105-108
30773008-2	2019	In this work, we developed a novel technique termed in-tip solvent microextraction mass spectrometry for the separation and profiling of phosphatidylcholines and triglycerides within a single LD.	Phosphatidylcholines	137-157	TOR signaling pathway regulator	Homo sapiens	55-58
30266576-7	2019	In addition, the major allele of TM6SF2, a set of phosphatidylcholines and several amino acids are associated with healthy livers in obesity.	Phosphatidylcholines	50-70	transmembrane 6 superfamily member 2	Homo sapiens	33-39
30639288-3	2019	Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets.	Phosphatidylcholines	146-165	pleckstrin and Sec7 domain containing 2	Homo sapiens	44-48
30639288-3	2019	Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets.	Phosphatidylcholines	167-171	pleckstrin and Sec7 domain containing 2	Homo sapiens	44-48
30615497-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
30615497-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	86-105	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
30615497-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
30615497-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	107-109	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
30320913-1	2019	Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid.	Phosphatidylcholines	50-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
30784133-0	2019	The mechanism of phosphatidylcholine-induced interference of PAP (248-286) aggregation.	Phosphatidylcholines	17-36	regenerating family member 3 alpha	Homo sapiens	61-64
30692541-4	2019	Oleic acid with or without tunicamycin significantly increases the formation of nucleoplasmic LDs, to which CDP-choline diacylglycerol phosphotransferase alpha (CCTalpha) is recruited, resulting in activation of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	212-231	phosphate cytidylyltransferase 1A, choline	Homo sapiens	161-169
31231513-2	2019	We previously found that LMS is caused by de novo dominant missense mutations in the  PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine.	Phosphatidylcholines	194-213	phosphatidylserine synthase 1a	Danio rerio	86-92
31231513-2	2019	We previously found that LMS is caused by de novo dominant missense mutations in the  PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine.	Phosphatidylcholines	194-213	phosphatidylserine synthase 1a	Danio rerio	113-142
30845751-5	2019	LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2).	Phosphatidylcholines	43-62	phospholipase A2 group IB	Homo sapiens	90-106
30845751-5	2019	LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2).	Phosphatidylcholines	43-62	phospholipase A2 group IB	Homo sapiens	108-112
30845751-5	2019	LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2).	Phosphatidylcholines	1-3	phospholipase A2 group IB	Homo sapiens	90-106
30845751-5	2019	LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A2 (PLA2).	Phosphatidylcholines	1-3	phospholipase A2 group IB	Homo sapiens	108-112
30509129-5	2019	By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature.	Phosphatidylcholines	50-69	ATPase phospholipid transporting 8B1	Homo sapiens	13-19
30509129-5	2019	By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature.	Phosphatidylcholines	50-69	ATPase phospholipid transporting 8B2	Homo sapiens	21-27
30509129-5	2019	By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature.	Phosphatidylcholines	50-69	ATPase phospholipid transporting 10A (putative)	Homo sapiens	33-39
30509129-5	2019	By contrast, ATP8B1, ATP8B2, and ATP10A transport phosphatidylcholine but not aminophospholipids, although there is a discrepancy regarding the substrate of ATP8B1 in the literature.	Phosphatidylcholines	50-69	ATPase phospholipid transporting 8B1	Homo sapiens	157-163
30366030-2	2019	Phosphocholine cytidylyltransferase (CCT) is the rate-limiting enzyme responsible for catalyzing the formation of PC.	Phosphatidylcholines	114-116	FLVCR heme transporter 2	Rattus norvegicus	37-40
30289748-0	2019	Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease.	Phosphatidylcholines	8-27	apolipoprotein E	Homo sapiens	46-51
30289748-9	2019	Dietary sources of DHA in phospholipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk of AD.-Patrick, R. P. Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease.	Phosphatidylcholines	163-182	apolipoprotein E	Homo sapiens	201-206
30820432-0	2019	The Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2.	Phosphatidylcholines	51-70	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	82-89
30820432-5	2019	Results: Choline-containing phospholipids, in particular PC, bind to mucin 2 as main scaffold protein of intestinal mucus to establish a hydrophobic barrier towards microbiota in the intestinal lumen.	Phosphatidylcholines	57-59	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	69-76
30559292-0	2019	Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTalpha impair enzymatic activity and fold stability.	Phosphatidylcholines	32-51	phosphate cytidylyltransferase 1A, choline	Homo sapiens	70-78
30559292-3	2019	Previous analyses showed that for some disease-linked PCYT1A variants steady state levels of CCTalpha and PC synthesis were reduced in patient fibroblasts, but other variants impaired PC synthesis with little effect on CCT levels.	Phosphatidylcholines	54-56	phosphate cytidylyltransferase 1A, choline	Homo sapiens	93-101
30559292-3	2019	Previous analyses showed that for some disease-linked PCYT1A variants steady state levels of CCTalpha and PC synthesis were reduced in patient fibroblasts, but other variants impaired PC synthesis with little effect on CCT levels.	Phosphatidylcholines	106-108	phosphate cytidylyltransferase 1A, choline	Homo sapiens	54-60
30518673-7	2019	The pmt1 pmt2 double mutant enhanced the defects in root growth, cell viability, and PC content of pmt1, suggesting that PMT2 functions together with PMT1 in roots.	Phosphatidylcholines	85-87	polyol/monosaccharide transporter 2	Arabidopsis thaliana	9-13
30518673-7	2019	The pmt1 pmt2 double mutant enhanced the defects in root growth, cell viability, and PC content of pmt1, suggesting that PMT2 functions together with PMT1 in roots.	Phosphatidylcholines	85-87	polyol/monosaccharide transporter 2	Arabidopsis thaliana	121-125
30518673-9	2019	In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis.	Phosphatidylcholines	110-112	polyol/monosaccharide transporter 2	Arabidopsis thaliana	16-20
30518673-9	2019	In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis.	Phosphatidylcholines	110-112	polyol/monosaccharide transporter 1	Arabidopsis thaliana	52-61
30518673-9	2019	In shoots, pmt1 pmt2 pmt3 enhanced the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detectable de novo PC biosynthesis.	Phosphatidylcholines	148-150	polyol/monosaccharide transporter 2	Arabidopsis thaliana	16-20
31231513-2	2019	We previously found that LMS is caused by de novo dominant missense mutations in the  PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine.	Phosphatidylcholines	194-213	phosphatidylserine synthase 1a	Danio rerio	144-148
30509129-8	2019	Here, we discuss the cellular functions of phosphatidylcholine flippases and suggest a model for the phenotype of progressive familial intrahepatic cholestasis 1 caused by a defect in ATP8B1.-Shin, H.-W., Takatsu, H. Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine).	Phosphatidylcholines	43-62	ATPase, class I, type 8B, member 1	Mus musculus	184-190
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Phosphatidylcholines	103-122	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-73
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Phosphatidylcholines	124-126	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-73
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Phosphatidylcholines	176-178	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-73
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Phosphatidylcholines	176-178	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-73
30692541-4	2019	Oleic acid with or without tunicamycin significantly increases the formation of nucleoplasmic LDs, to which CDP-choline diacylglycerol phosphotransferase alpha (CCTalpha) is recruited, resulting in activation of phosphatidylcholine (PC) synthesis.	Phosphatidylcholines	233-235	phosphate cytidylyltransferase 1A, choline	Homo sapiens	161-169
30625315-4	2019	Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling.	Phosphatidylcholines	30-49	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
30580923-1	2019	Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an appropriate and essential lipid signaling environment for membrane trafficking from trans-Golgi membranes.	Phosphatidylcholines	23-42	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
30580923-1	2019	Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an appropriate and essential lipid signaling environment for membrane trafficking from trans-Golgi membranes.	Phosphatidylcholines	44-46	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	0-5
30629659-2	2019	During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	78-84	choline kinase alpha	Homo sapiens	114-118
30629659-2	2019	During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	78-84	choline kinase alpha	Homo sapiens	128-153
30629659-2	2019	During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	78-84	phosphate cytidylyltransferase 1A, choline	Homo sapiens	166-172
30629659-2	2019	During neuroblast differentiation, the transcription of two genes involved in PtdCho biosynthesis are stimulated: Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Phosphatidylcholines	78-84	phosphate cytidylyltransferase 1A, choline	Homo sapiens	182-233
30580923-8	2019	Finally, wild-type Sec14, but not a mixture of Sec14 proteins specifically deficient in either PC- or PI-binding activity, was able to effect a net transfer of PI or PC down opposing concentration gradients in vitro.	Phosphatidylcholines	95-97	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	19-24
30625315-4	2019	Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling.	Phosphatidylcholines	30-49	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
30766963-2	2019	PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	44-63	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-4
30610190-4	2019	The crystal structure of a representative TCR bound to CD1b-phosphatidylcholine provides a molecular mechanism for this promiscuous recognition.	Phosphatidylcholines	60-79	CD1b molecule	Homo sapiens	55-59
30611309-3	2019	StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events.	Phosphatidylcholines	75-94	StAR related lipid transfer domain containing 10	Homo sapiens	0-38
30611309-3	2019	StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events.	Phosphatidylcholines	75-94	StAR related lipid transfer domain containing 10	Homo sapiens	40-47
30611309-3	2019	StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events.	Phosphatidylcholines	96-98	StAR related lipid transfer domain containing 10	Homo sapiens	0-38
30611309-3	2019	StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events.	Phosphatidylcholines	96-98	StAR related lipid transfer domain containing 10	Homo sapiens	40-47
30766963-2	2019	PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis.	Phosphatidylcholines	65-67	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-4
30766963-6	2019	We hypothesized that PEMT is an important supplier of PC to the canaliculus and that PEMT activity is critical for the maintenance of canalicular membrane integrity and bile formation following HFD feeding when there is an increase in overall hepatic PC demand.	Phosphatidylcholines	54-56	phosphatidylethanolamine N-methyltransferase	Mus musculus	21-25
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Phosphatidylcholines	95-114	sphingomyelin synthase 1	Mus musculus	19-32
30300671-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver.	Phosphatidylcholines	94-113	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
30300671-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver.	Phosphatidylcholines	94-113	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
30300671-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver.	Phosphatidylcholines	115-117	phosphatidylethanolamine N-methyltransferase	Mus musculus	0-44
30300671-1	2019	Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver.	Phosphatidylcholines	115-117	phosphatidylethanolamine N-methyltransferase	Mus musculus	46-50
30299003-1	2019	The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system.	Phosphatidylcholines	159-178	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
30299003-1	2019	The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system.	Phosphatidylcholines	159-178	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
30299003-1	2019	The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system.	Phosphatidylcholines	180-182	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
30299003-1	2019	The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system.	Phosphatidylcholines	180-182	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Phosphatidylcholines	95-114	sphingomyelin synthase 1	Mus musculus	34-38
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Phosphatidylcholines	95-114	beta-site APP cleaving enzyme 1	Mus musculus	198-229
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Phosphatidylcholines	95-114	beta-site APP cleaving enzyme 1	Mus musculus	231-236
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Phosphatidylcholines	95-114	amyloid beta (A4) precursor protein	Mus musculus	279-284
30587782-2	2018	PLDalpha1 has a substrate preference for phosphatidylcholine leading to enzymatic production of phosphatidic acid, a lipid second messenger with multiple cellular functions.	Phosphatidylcholines	41-60	phospholipase D alpha 1	Arabidopsis thaliana	0-9
30455469-4	2019	Genetic and in vitro characterization of the PLD from Escherichia coli MS 200-1 showed this enzyme is essential for bacterial hydrolysis of PC and prefers this substrate.	Phosphatidylcholines	140-142	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
30315445-1	2018	StarD7 is a lipid binding protein involved in the delivery of phosphatidylcholine to the mitochondria whose promoter is activated by Wnt/beta-catenin signaling.	Phosphatidylcholines	62-81	StAR related lipid transfer domain containing 7	Homo sapiens	0-6
30577564-1	2018	This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property.	Phosphatidylcholines	27-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	182-198
30577564-1	2018	This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property.	Phosphatidylcholines	48-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	182-198
30159756-6	2018	Pretreatment with S117A-FGF2 protected against Dox-induced: oxidative stress; upregulation of fragmented and non-fragmented oxidized phosphatidylcholine species, measured by LC/MS/MS; and cardiomyocyte injury and cell death measured by LDH release and a live-dead assay.	Phosphatidylcholines	133-152	fibroblast growth factor 2	Homo sapiens	24-28
30369483-1	2018	Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions.	Phosphatidylcholines	0-19	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-49
30369483-1	2018	Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions.	Phosphatidylcholines	0-19	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	51-54
30369483-1	2018	Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions.	Phosphatidylcholines	21-23	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-49
30369483-1	2018	Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions.	Phosphatidylcholines	21-23	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	51-54
30103144-1	2018	Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol.	Phosphatidylcholines	63-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
30103144-1	2018	Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol.	Phosphatidylcholines	63-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
30054282-0	2018	[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.	Phosphatidylcholines	78-97	TSC complex subunit 1	Homo sapiens	152-155
30054282-6	2018	RESULTS: We previously reported that TSC2-deficient cells enhance phosphatidylcholine synthesis via the Kennedy pathway.	Phosphatidylcholines	66-85	TSC complex subunit 2	Homo sapiens	37-41
30315445-1	2018	StarD7 is a lipid binding protein involved in the delivery of phosphatidylcholine to the mitochondria whose promoter is activated by Wnt/beta-catenin signaling.	Phosphatidylcholines	62-81	catenin beta 1	Homo sapiens	137-149
30218542-4	2018	Here, we show that PMT1 and PMT3 redundantly play an essential role in phosphocholine (PCho) biosynthesis, a prerequisite for PtdCho production.	Phosphatidylcholines	126-132	polyol/monosaccharide transporter 1	Arabidopsis thaliana	19-23
30218542-5	2018	A pmt1 pmt3 double mutant was devoid of PCho, which affected PtdCho biosynthesis in vivo, showing severe growth defects in post-embryonic development.	Phosphatidylcholines	61-67	polyol/monosaccharide transporter 1	Arabidopsis thaliana	2-6
30218542-8	2018	We suggest that PMT1 and PMT3 are the primary enzymes for PCho biosynthesis and are involved in PtdCho biosynthesis and vascular development in Arabidopsis seedlings.	Phosphatidylcholines	96-102	polyol/monosaccharide transporter 1	Arabidopsis thaliana	16-20
30359036-0	2018	Nonclassical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study.	Phosphatidylcholines	29-48	LOC100508689	Homo sapiens	54-59
30477200-7	2018	Reducing the ratio of PC to PE increased the binding of perilipin 2 to liposomes in an in vitro experiment.	Phosphatidylcholines	22-24	perilipin 2	Rattus norvegicus	56-67
30305392-9	2018	The treatment inhibited lysophosphatidylcholine acyltransferase (LPCAT) activity, consistent with the aforementioned reduction in plasma phosphatidylcholine.	Phosphatidylcholines	28-47	lysophosphatidylcholine acyltransferase 1	Homo sapiens	65-70
30359036-9	2018	The fact that phosphatidylcholine sustains the binding capability to enzymatically degraded mucin suggests that the direct delivery of phosphatidylcholine to the damaged mucus is a promising strategy for the better treatment of patients affected by inflammatory bowel diseases.	Phosphatidylcholines	14-33	LOC100508689	Homo sapiens	92-97
30359036-9	2018	The fact that phosphatidylcholine sustains the binding capability to enzymatically degraded mucin suggests that the direct delivery of phosphatidylcholine to the damaged mucus is a promising strategy for the better treatment of patients affected by inflammatory bowel diseases.	Phosphatidylcholines	135-154	LOC100508689	Homo sapiens	92-97
30360613-7	2018	The interaction with a planar lipid bilayer composed of phosphatidylcholine and cholesterol with myristoylated and nonmyristoylated recoverin is studied by in situ polarization modulation infrared reflection absorption spectroscopy.	Phosphatidylcholines	56-75	recoverin	Homo sapiens	132-141
30357767-1	2018	ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile.	Phosphatidylcholines	142-161	ATP binding cassette subfamily B member 4	Homo sapiens	0-41
30281048-0	2018	Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition.	Phosphatidylcholines	0-19	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	54-63
30281048-0	2018	Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition.	Phosphatidylcholines	0-19	protein C receptor	Homo sapiens	74-78
30281048-0	2018	Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition.	Phosphatidylcholines	0-19	protein C receptor	Homo sapiens	90-94
30281048-0	2018	Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition.	Phosphatidylcholines	0-19	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	112-121
30281048-5	2018	Molecular dynamics simulations along with potential of mean force (PMF) calculations were carried out in order to provide molecular insight into the dynamics and free energies of EPCR-PC in the absence/presence of phospholipid, namely lysophosphatidylcholine (lysoPCh) and phosphatidylcholine (PCh) in the antigen-binding groove of the EPCR.	Phosphatidylcholines	239-258	protein C receptor	Homo sapiens	179-183
30281048-8	2018	With regards to the two hydrophobic tails of PCh, one lipid tail regulates EPCR conformation while the other promotes ligand recognition by interacting with the keel residue (Phe-4) of PC.	Phosphatidylcholines	45-48	protein C receptor	Homo sapiens	75-79
30281048-10	2018	Our studies for the first time explore the possible mode of ligand recognition by the EPCR via the involvement of phosphatidylcholine within its hydrophobic groove.	Phosphatidylcholines	114-133	protein C receptor	Homo sapiens	86-90
29935094-3	2018	Soya lecithin origin phosphatidylcholine (soya PC) was identified as a natural TLR4 antagonist by computational study.	Phosphatidylcholines	21-40	toll-like receptor 4	Rattus norvegicus	79-83
30343580-3	2018	A KAT derivative of oleic acid (OA-KAT, 1) was added to a mixture of three lipid components (triolein, phosphatidyl choline, and cholesteryl oleate), which have been commonly used as substrates for lipid nanoparticles.	Phosphatidylcholines	103-123	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	2-5
30357767-1	2018	ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile.	Phosphatidylcholines	142-161	ATP binding cassette subfamily B member 4	Homo sapiens	43-48
30199242-5	2018	In this work, we report on the observation that phosphatidylcholines form abundant doubly charged metal ion complexes during electrospray ionization (ESI) and show that these complexes can be used to assign fatty acid moieties, relatively quantify sn-isomers in MS2 experiments, and mass spectrometrically separate phosphatidylcholines from other phospholipid classes in positive ion mode.	Phosphatidylcholines	48-68	MS2	Homo sapiens	262-265
30226041-2	2018	One pathway for the biosynthesis of the abundant lipid phosphatidylcholine in eukaryotes involves a membrane-integrated phospholipid methyltransferase named Opi3 in yeast.	Phosphatidylcholines	55-74	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	157-161
30226041-3	2018	A still unanswered question is whether Opi3 can catalyze phosphatidylcholine synthesis in trans, at membrane contact sites.	Phosphatidylcholines	57-76	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	39-43
30226041-9	2018	Phosphatidylcholine formation was observed not only in nanodiscs containing inserted Opi3 but also in nanodiscs devoid of the enzyme containing the lipid substrate.	Phosphatidylcholines	0-19	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	85-89
30830399-8	2018	Phosphatidylcholines, lyso-phosphatidylcholines and fatty acids were significantly changed among pathological samples suggesting changes in phospholipase A2 and arachidonic acid metabolic pathways.	Phosphatidylcholines	0-20	phospholipase A2 group IB	Homo sapiens	140-156