PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25204405-7	2014	These polyglutamates were further evaluated for their relationship with DAS28-3v (CRP).	Polyglutamic Acid	6-20	C-reactive protein	Homo sapiens	82-85
25761689-0	2015	Extraction of histone H1 and decondensation of nuclear chromatin with various Mg-dependent organization levels under treatment with polyglutamic acid and distamycin.	Polyglutamic Acid	132-149	H1.0 linker histone	Rattus norvegicus	14-24
25761689-3	2015	Poly-L-glutamic acid (PG) at weight ratio PG/DNA = 6 and in the presence of 5 mM Mg2+ extracts only about 1/8 of nuclear histone H1, preserving a condensed chromatin structure.	Polyglutamic Acid	22-24	H1.0 linker histone	Rattus norvegicus	121-131
25761689-11	2015	Decondensation of chromatin in the nucleus is not always proportional to the yield of extracted histone H1 and is weakened in the presence of positively charged DM or high concentrations of PG.	Polyglutamic Acid	190-192	H1.0 linker histone	Rattus norvegicus	96-106
25416787-2	2015	Nna1, CCP4, and CCP6 are involved in the post-translational process of polyglutamylation, where they catalyze the removal of polyglutamate side chains.	Polyglutamic Acid	125-138	ATP/GTP binding protein 1	Mus musculus	0-4
25416787-2	2015	Nna1, CCP4, and CCP6 are involved in the post-translational process of polyglutamylation, where they catalyze the removal of polyglutamate side chains.	Polyglutamic Acid	125-138	ATP/GTP binding protein-like 1	Mus musculus	6-10
25290812-4	2014	In terms of suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver and low-density-lipoprotein (LDL) and very low-density-lipoprotein (VLDL) cholesterol level in serum were reduced at 48 h after single sequential injection of PGA or CS plus cationic lipoplex of cholesterol-modified ApoB siRNA.	Polyglutamic Acid	253-256	apolipoprotein B	Homo sapiens	52-68
25290812-4	2014	In terms of suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver and low-density-lipoprotein (LDL) and very low-density-lipoprotein (VLDL) cholesterol level in serum were reduced at 48 h after single sequential injection of PGA or CS plus cationic lipoplex of cholesterol-modified ApoB siRNA.	Polyglutamic Acid	253-256	apolipoprotein B	Homo sapiens	70-74
25144464-0	2014	Covalent defects restrict supramolecular self-assembly of homopolypeptides: case study of beta2-fibrils of poly-L-glutamic acid.	Polyglutamic Acid	107-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	90-95
24937179-6	2014	Both Poly-L-Glutamate (PLG) and Heparinase-1 reversed the up-regulatory effect of EPO on ChAT and VAChT expression and prevented EPO adhesion to the cell surface.	Polyglutamic Acid	5-21	eosinophil peroxidase	Homo sapiens	82-85
24937179-6	2014	Both Poly-L-Glutamate (PLG) and Heparinase-1 reversed the up-regulatory effect of EPO on ChAT and VAChT expression and prevented EPO adhesion to the cell surface.	Polyglutamic Acid	5-21	eosinophil peroxidase	Homo sapiens	129-132
24993872-9	2014	The mutation, confirmed by 3 orthogonal methods, alters an evolutionarily conserved region of the HMGB3 protein from a negatively charged polyglutamic acid tract to a positively charged arginine-rich motif that is likely to interfere with normal protein function.	Polyglutamic Acid	138-155	high mobility group box 3	Homo sapiens	98-103
24754871-7	2014	DHFR inhibition of the conjugates significantly increased with increasing polyglutamate chain length.	Polyglutamic Acid	74-87	dihydrofolate reductase	Homo sapiens	0-4
23999654-3	2013	In this investigation the Donnan potential of PEI-(PGA-PAH)n (PEI, PGA and PAH stand for polyethyleneimine, poly-L-glutamic acid and polyallylamine) films will be determined as a function of the number of deposition steps and the concentration of the redox probe, hexacyanoferrate anions, for films made from 10 layer pairs.	Polyglutamic Acid	108-128	phenylalanine hydroxylase	Homo sapiens	55-58
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Polyglutamic Acid	167-170	apolipoprotein B	Mus musculus	56-72
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Polyglutamic Acid	167-170	apolipoprotein B	Mus musculus	74-78
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Polyglutamic Acid	167-170	apolipoprotein B	Mus musculus	190-194
24635769-8	2014	The polyglutamate-dependent pathway of the IDS involves activation of the quiescent center independently of auxin gradients and regulatory modules participating in RAM maintenance (WUSCHEL-RELATED HOMEOBOX5 (WOX5), PLETHORA, and SCARECROW (SCR)).	Polyglutamic Acid	4-17	WUSCHEL related homeobox 5	Arabidopsis thaliana	181-206
24635769-8	2014	The polyglutamate-dependent pathway of the IDS involves activation of the quiescent center independently of auxin gradients and regulatory modules participating in RAM maintenance (WUSCHEL-RELATED HOMEOBOX5 (WOX5), PLETHORA, and SCARECROW (SCR)).	Polyglutamic Acid	4-17	WUSCHEL related homeobox 5	Arabidopsis thaliana	208-212
24635769-8	2014	The polyglutamate-dependent pathway of the IDS involves activation of the quiescent center independently of auxin gradients and regulatory modules participating in RAM maintenance (WUSCHEL-RELATED HOMEOBOX5 (WOX5), PLETHORA, and SCARECROW (SCR)).	Polyglutamic Acid	4-17	GRAS family transcription factor	Arabidopsis thaliana	229-238
24635769-8	2014	The polyglutamate-dependent pathway of the IDS involves activation of the quiescent center independently of auxin gradients and regulatory modules participating in RAM maintenance (WUSCHEL-RELATED HOMEOBOX5 (WOX5), PLETHORA, and SCARECROW (SCR)).	Polyglutamic Acid	4-17	GRAS family transcription factor	Arabidopsis thaliana	240-243
24053614-1	2013	Polyglutamic acid at low pH forms aggregates and self-assembles into a spiral, fibril-like superstructure formed as a beta2-type sheet conformation that has a more compact intersheet packing than commonly found.	Polyglutamic Acid	0-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
23999654-3	2013	In this investigation the Donnan potential of PEI-(PGA-PAH)n (PEI, PGA and PAH stand for polyethyleneimine, poly-L-glutamic acid and polyallylamine) films will be determined as a function of the number of deposition steps and the concentration of the redox probe, hexacyanoferrate anions, for films made from 10 layer pairs.	Polyglutamic Acid	108-128	phenylalanine hydroxylase	Homo sapiens	75-78
22835831-9	2012	Nna1 is a monomeric enzyme essential for neuronal survival through hydrolysis of polyglutamate-containing substrates.	Polyglutamic Acid	81-94	ATP/GTP binding protein 1	Mus musculus	0-4
24339545-2	2013	Exon 1 of the human POLG contains CAG trinucleotide repeat, which codes for polyglutamate.	Polyglutamic Acid	76-89	DNA polymerase gamma, catalytic subunit	Homo sapiens	20-24
23598077-1	2013	pH-sensitive poly(L-glutamic acid) grafted mesoporous silica nanoparticles (MSN-PLGA) were prepared by the surface-initiated N-carboxyanhydride polymerization method.	Polyglutamic Acid	13-34	moesin	Homo sapiens	76-79
23617546-0	2013	Salt-induced stability and serum-resistance of polyglutamate polyelectrolyte brushes/nuclear factor-kappaB p65 siRNA Polyplex enhance the apoptosis and efficacy of doxorubicin.	Polyglutamic Acid	47-60	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-110
23617546-4	2013	In the present study we developed the polyglutamate derivatives (PGS) polyelectrolyte brushes for NF-kappaB p65 siRNA delivery.	Polyglutamic Acid	38-51	nuclear factor kappa B subunit 1	Homo sapiens	98-107
23617546-4	2013	In the present study we developed the polyglutamate derivatives (PGS) polyelectrolyte brushes for NF-kappaB p65 siRNA delivery.	Polyglutamic Acid	38-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-111
23412628-3	2013	[(3)H]Polyglutamate metabolites of compound 2 were measured in R1-11-PCFT4 and H2452 cells.	Polyglutamic Acid	6-19	solute carrier family 46 member 1	Homo sapiens	63-74
23390294-0	2013	A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties.	Polyglutamic Acid	2-19	interleukin 27	Homo sapiens	34-39
23390294-4	2013	The IL-27 polyglutamic acid domain is located in a flexible inter-alpha helix loop, and HA-bound IL-27 retained biological activity.	Polyglutamic Acid	10-27	interleukin 27	Homo sapiens	4-9
23269380-2	2013	METHODS: tPA was conjugated to Polyglutamate, and the activity of oligoanion-modified tPA was tested by fibrinolytic assay.	Polyglutamic Acid	31-44	chromosome 20 open reading frame 181	Homo sapiens	9-12
24348038-1	2013	Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid.	Polyglutamic Acid	259-279	transferrin	Homo sapiens	0-11
23090921-1	2013	We investigated the effect of a novel porous scaffold composed with water-soluble poly(L-glutamic acid) (PLGA) and chitosan (CS) on the attachment, proliferation, and adipogenic differentiation of human adipose tissue-derived adult stem cells (ADSCs) in vitro and in vivo.	Polyglutamic Acid	82-103	WD and tetratricopeptide repeats 1	Mus musculus	203-210
23949282-2	2013	This drug is converted intracellularly into polyglutamate derivates by the enzyme folylpolyglutamate synthase (FPGS).	Polyglutamic Acid	44-57	folylpolyglutamate synthase	Homo sapiens	82-109
23949282-2	2013	This drug is converted intracellularly into polyglutamate derivates by the enzyme folylpolyglutamate synthase (FPGS).	Polyglutamic Acid	44-57	folylpolyglutamate synthase	Homo sapiens	111-115
23712926-10	2013	For the films containing either PAA or PGA, the pH of the polymer solutions used for construction was found to have a significant effect on the response of the multilayer films, and the electrochemical response of the Fc-C6-LPEI/PAA, Fc-C6-LPEI/PGA, or covalently assembled Fc-C6-LPEI/GOX films could be tuned by varying the number of bilayers (n=1-16) in the film.	Polyglutamic Acid	39-42	hydroxyacid oxidase 1	Homo sapiens	285-288
23390294-5	2013	Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo.	Polyglutamic Acid	54-71	interleukin 27	Homo sapiens	6-11
23390294-5	2013	Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo.	Polyglutamic Acid	54-71	golgi SNAP receptor complex member 1	Homo sapiens	50-53
23390294-5	2013	Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo.	Polyglutamic Acid	54-71	interleukin 27	Homo sapiens	122-127
21411921-1	2011	By using poly-L-glutamic acid (PLGA) to modify the membrane surface of bacterial magnetic nanoparticles (BMPs), (BMP)-doxorubicin conjugates (DBMP-P) could be control generated.	Polyglutamic Acid	9-29	bone morphogenetic protein 1	Homo sapiens	105-108
22326478-4	2012	Heparin, polyglutamate, arachidonic acid micelles, and RNA all induce p25alpha aggregation.	Polyglutamic Acid	9-22	tubulin polymerization promoting protein	Homo sapiens	70-78
22201843-9	2012	The poly glutamic acid sequences of BSP act as possible nucleation sites for hydroxyapatite crystals.	Polyglutamic Acid	4-22	integrin binding sialoprotein	Homo sapiens	36-39
22610659-1	2012	Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating.	Polyglutamic Acid	64-85	Bdnf	Cavia porcellus	13-17
21830492-3	2011	In our group, we have shown that when covalently coupled to Poly-Glutamic Acid (PGA) the incorporation of an anti-inflammatory hormone (melanocortin, a-MSH) into the multilayered films Poly-L-Lysine (PLL)/PGA increases the anti-inflammatory reaction of pulp fibroblasts and macrophages stimulated by LPS (Lipo-Polysaccharides).	Polyglutamic Acid	60-78	proopiomelanocortin	Homo sapiens	152-155
21830492-3	2011	In our group, we have shown that when covalently coupled to Poly-Glutamic Acid (PGA) the incorporation of an anti-inflammatory hormone (melanocortin, a-MSH) into the multilayered films Poly-L-Lysine (PLL)/PGA increases the anti-inflammatory reaction of pulp fibroblasts and macrophages stimulated by LPS (Lipo-Polysaccharides).	Polyglutamic Acid	80-83	proopiomelanocortin	Homo sapiens	152-155
21830492-3	2011	In our group, we have shown that when covalently coupled to Poly-Glutamic Acid (PGA) the incorporation of an anti-inflammatory hormone (melanocortin, a-MSH) into the multilayered films Poly-L-Lysine (PLL)/PGA increases the anti-inflammatory reaction of pulp fibroblasts and macrophages stimulated by LPS (Lipo-Polysaccharides).	Polyglutamic Acid	205-208	proopiomelanocortin	Homo sapiens	152-155
20188560-4	2010	Here, using a novel Chlamydomonas reinhardtii mutant (tpg1) that lacks a homolog of human TTLL9, a glutamic acid ligase enzyme [3], we found that the lack of a long polyglutamate side chain in alpha-tubulin moderately weakens flagellar motility without noticeably impairing the axonemal structure.	Polyglutamic Acid	165-178	tubulin tyrosine ligase like 9	Homo sapiens	90-95
21074048-4	2010	Three enzymes (CCP1, CCP4, and CCP6) catalyze the shortening of polyglutamate chains and a fourth (CCP5) specifically removes the branching point glutamates.	Polyglutamic Acid	64-77	granzyme B	Mus musculus	15-19
21074048-4	2010	Three enzymes (CCP1, CCP4, and CCP6) catalyze the shortening of polyglutamate chains and a fourth (CCP5) specifically removes the branching point glutamates.	Polyglutamic Acid	64-77	ATP/GTP binding protein-like 1	Mus musculus	21-25
21314600-0	2010	Influence of distamycin, chromomycin, and UV-irradiation on extraction of histone H1 from rat liver nuclei by polyglutamic acid.	Polyglutamic Acid	110-127	H1.0 linker histone	Rattus norvegicus	74-84
20507154-4	2010	Our recent studies have shown that alpha-MSH covalently coupled to poly-l-glutamic acid (PGA-alpha-MSH) retains anti-inflammatory properties on rat monocytes.	Polyglutamic Acid	67-87	proopiomelanocortin	Rattus norvegicus	35-44
20507154-4	2010	Our recent studies have shown that alpha-MSH covalently coupled to poly-l-glutamic acid (PGA-alpha-MSH) retains anti-inflammatory properties on rat monocytes.	Polyglutamic Acid	67-87	proopiomelanocortin	Rattus norvegicus	93-102
20201548-2	2010	The cancer therapeutic, doxorubicin hydrochloride (DOX), was conjugated to alkyne-functionalized poly(l-glutamic acid) (PGA(Alk)) via amide bond formation.	Polyglutamic Acid	97-118	ALK receptor tyrosine kinase	Homo sapiens	124-127
21126103-2	2011	Poly(L-glutamic acid) modified with alkyne moieties (PGA(Alk)) was alternately assembled with poly(N-vinyl pyrrolidone) (PVPON) on silica particles via hydrogen-bonding.	Polyglutamic Acid	0-21	ALK receptor tyrosine kinase	Homo sapiens	57-60
20509699-2	2010	Here we show that the beta(2) structural variant of poly(l-glutamic) acid forms fibrils with an amyloid-like morphology, ability to enhance fluorescence of thioflavin T, and seeding properties.	Polyglutamic Acid	52-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
20509699-3	2010	The beta(2) fibrils are formed upon heating of aqueous solutions of alpha-helical poly(l-glutamic) acid, which leads to a significant increase of pD (pH) of unbuffered samples and a concomitant precipitation of fibrils with unusual infrared traits: amide I" band being dramatically red-shifted to 1596 cm(-1), and the -COOD stretching band split into two peaks around 1730 and 1719 cm(-1).	Polyglutamic Acid	82-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-10
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	dihydrofolate reductase	Homo sapiens	130-153
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	dihydrofolate reductase	Homo sapiens	155-159
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	166-210
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	212-217
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	thymidylate synthetase	Homo sapiens	225-229
17644445-3	2007	The C-terminus of the deduced proteins had a polyglutamic acid (polyE) stretch that is not found in other vertebrate HspB1s.	Polyglutamic Acid	45-62	heat shock protein, alpha-crystallin-related, 1	Oncorhynchus mykiss	117-122
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	thymidylate synthetase	Homo sapiens	100-121
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Polyglutamic Acid	0-13	thymidylate synthetase	Homo sapiens	123-127
18713736-5	2008	Both polyaspartate and polyglutamate blocked LPL and chylomicron binding to GPIHBP1.	Polyglutamic Acid	23-36	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	45-48
18713736-5	2008	Both polyaspartate and polyglutamate blocked LPL and chylomicron binding to GPIHBP1.	Polyglutamic Acid	23-36	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	Cricetulus griseus	76-83
18341412-1	2008	Huntington disease (HD), caused by polyglutamate expansions in the huntingtin protein, is a progressive neurodegenerative disease resulting in cognitive and motor impairments and death.	Polyglutamic Acid	35-48	huntingtin	Homo sapiens	67-77
18710273-0	2008	Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers.	Polyglutamic Acid	17-34	integrin subunit alpha V	Homo sapiens	85-86
18710273-4	2008	Here, we report the synthesis of a peptide targeted polyglutamic acid polymer in which the high affinity alpha(v)beta(6)-specific tetrameric H2009.1 peptide is incorporated via a thioether at the N-terminus of a 15 amino acid polymer of glutamic acid.	Polyglutamic Acid	52-69	integrin subunit alpha V	Homo sapiens	111-112
17325736-2	2007	MTX enters the cells through the reduced folate carrier (RFC-1) and is activated to polyglutamates.	Polyglutamic Acid	84-98	replication factor C subunit 1	Homo sapiens	57-62
17325736-4	2007	The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype.	Polyglutamic Acid	242-255	replication factor C subunit 1	Homo sapiens	46-51
18025275-1	2007	Folylpolyglutamyl synthase (FPGS) converts intracellular folates and antifolates to polyglutamates.	Polyglutamic Acid	84-98	folylpolyglutamate synthase	Homo sapiens	0-26
18025275-1	2007	Folylpolyglutamyl synthase (FPGS) converts intracellular folates and antifolates to polyglutamates.	Polyglutamic Acid	84-98	folylpolyglutamate synthase	Homo sapiens	28-32
17320947-6	2007	Eighty percent of the FGF-2 was released at controlled rates from gelatin-polylysine (gelatin-PLL) and gelatin-polyglutamic acid (gelatin-PLG) hydrogel scaffolds over a period of 28 days.	Polyglutamic Acid	111-128	fibroblast growth factor 2	Mus musculus	22-27
17330862-7	2007	Predictably, other hydrophilic flexible polyanions such as heparin, polyglutamate, and polyadenylate also have a destabilizing effect on the structure of cyt c.	Polyglutamic Acid	68-81	cytochrome c, somatic	Homo sapiens	154-159
17320947-6	2007	Eighty percent of the FGF-2 was released at controlled rates from gelatin-polylysine (gelatin-PLL) and gelatin-polyglutamic acid (gelatin-PLG) hydrogel scaffolds over a period of 28 days.	Polyglutamic Acid	111-128	plasminogen	Mus musculus	138-141
17334909-4	2007	For chemotherapeutic antifolates used for cancer such as methotrexate or pemetrexed, synthesis of mutant RFCs or loss of RFC transcripts and proteins results in antifolate resistance due to incomplete inhibition of cellular enzyme targets and insufficient substrate for polyglutamate synthesis.	Polyglutamic Acid	270-283	solute carrier family 19 member 1	Homo sapiens	105-108
16826517-1	2006	Gamma-glutamyl hydrolase (GGH) catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate (MTX).	Polyglutamic Acid	67-81	gamma-glutamyl hydrolase	Homo sapiens	0-24
17308042-3	2007	These include (a) its very rapid conversion to active polyglutamate derivatives in cells that build to high levels and are retained for long intervals to achieve prolonged and potent inhibition of its major target enzyme thymidylate synthase, (b) its high affinity for three folate transporters, and (c) its marked sensitivity to the level of physiologic folates in cells.	Polyglutamic Acid	54-67	thymidylate synthetase	Homo sapiens	221-241
16957163-0	2007	In vivo functional analysis of polyglutamic acid domains in recombinant bone sialoprotein.	Polyglutamic Acid	31-48	integrin-binding sialoprotein	Rattus norvegicus	72-89
16859665-3	2006	Whereas the addition of multiple glutamates is necessary to enable the cell to retain folates and anti-folates, hydrolysis of the polyglutamate tails by GGH has the opposite effect of making (anti)-folates exportable again.	Polyglutamic Acid	130-143	gamma-glutamyl hydrolase	Homo sapiens	153-156
16982928-6	2006	Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge.	Polyglutamic Acid	68-88	matrix metallopeptidase 1	Homo sapiens	110-115
16982928-6	2006	Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge.	Polyglutamic Acid	68-88	myelin basic protein	Homo sapiens	159-162
16982928-6	2006	Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge.	Polyglutamic Acid	68-88	eosinophil peroxidase	Homo sapiens	168-171
16982928-6	2006	Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge.	Polyglutamic Acid	68-88	endothelin 1	Homo sapiens	215-227
16826517-1	2006	Gamma-glutamyl hydrolase (GGH) catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate (MTX).	Polyglutamic Acid	67-81	gamma-glutamyl hydrolase	Homo sapiens	26-29
16489829-2	2006	It has been shown in a previous paper that phospholipid vesicles can be incorporated without spontaneous bilayer rupture into poly-L-glutamic acid/poly(allylamine) (PGA/PAH) multilayered polyelectrolyte films.	Polyglutamic Acid	126-146	phenylalanine hydroxylase	Homo sapiens	169-172
16699957-3	2006	In addition, other anionic polymers, like poly-glutamic acid and heparin also inhibit DFF40/CAD, the latter one being highly effective at nanomolar concentrations.	Polyglutamic Acid	42-60	DNA fragmentation factor subunit beta	Homo sapiens	86-91
16699957-3	2006	In addition, other anionic polymers, like poly-glutamic acid and heparin also inhibit DFF40/CAD, the latter one being highly effective at nanomolar concentrations.	Polyglutamic Acid	42-60	aconitate decarboxylase 1	Homo sapiens	92-95
16789732-0	2006	Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.	Polyglutamic Acid	0-20	apoptotic peptidase activating factor 1	Homo sapiens	47-85
16789732-0	2006	Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.	Polyglutamic Acid	0-20	apoptotic peptidase activating factor 1	Homo sapiens	87-93
16789732-0	2006	Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.	Polyglutamic Acid	22-25	apoptotic peptidase activating factor 1	Homo sapiens	47-85
16789732-0	2006	Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.	Polyglutamic Acid	22-25	apoptotic peptidase activating factor 1	Homo sapiens	87-93
16789732-1	2006	An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA).	Polyglutamic Acid	178-198	apoptotic peptidase activating factor 1	Homo sapiens	145-151
16789732-1	2006	An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA).	Polyglutamic Acid	41-44	apoptotic peptidase activating factor 1	Homo sapiens	105-143
16789732-1	2006	An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA).	Polyglutamic Acid	41-44	apoptotic peptidase activating factor 1	Homo sapiens	145-151
16707018-1	2006	BACKGROUND: Expression of folylpoly-gamma-glutamate synthetase (FPGS) gene is two- to three-fold higher in B-precursor ALL (Bp- ALL) than in T-lineage ALL (T-ALL) and correlates with intracellular accumulation of methotrexate (MTX) polyglutamates and lymphoblast sensitivity to MTX.	Polyglutamic Acid	232-246	folylpolyglutamate synthase	Homo sapiens	26-62
16707018-1	2006	BACKGROUND: Expression of folylpoly-gamma-glutamate synthetase (FPGS) gene is two- to three-fold higher in B-precursor ALL (Bp- ALL) than in T-lineage ALL (T-ALL) and correlates with intracellular accumulation of methotrexate (MTX) polyglutamates and lymphoblast sensitivity to MTX.	Polyglutamic Acid	232-246	folylpolyglutamate synthase	Homo sapiens	64-68
16475822-13	2006	While the positively charged poly-L-lysine, PLL, did not show any significant effect, negatively charged poly-L-glutamic acid, PLG, stabilized both heterodimers and homodimers by 2-3 kJ/mol.	Polyglutamic Acid	105-125	plasminogen	Homo sapiens	127-130
15709201-1	2005	Pemetrexed is a novel antifolate with polyglutamate derivatives that are potent inhibitors of thymidylate synthase (TS) and to a lesser extent glycinamide ribonucleotide formyltransferase (GARFT).	Polyglutamic Acid	38-51	thymidylate synthetase	Homo sapiens	94-114
16537174-2	2006	A model enzyme, glucose oxidase (GOx), was encapsulated by repeated stepwise adsorption of poly(L-lysine) and poly(L-glutamic acid) onto GOx-coated CaCO3 templates.	Polyglutamic Acid	110-131	hydroxyacid oxidase 1	Homo sapiens	16-31
16537174-2	2006	A model enzyme, glucose oxidase (GOx), was encapsulated by repeated stepwise adsorption of poly(L-lysine) and poly(L-glutamic acid) onto GOx-coated CaCO3 templates.	Polyglutamic Acid	110-131	hydroxyacid oxidase 1	Homo sapiens	33-36
16100259-5	2005	These stimulatory effects cannot be obtained with polyglutamic acid or RNA, suggesting that yNAP-1 impact on the reaction cannot simply be explained in terms of charge screening.	Polyglutamic Acid	50-67	histone chaperone NAP1	Saccharomyces cerevisiae S288C	92-98
15964901-5	2005	Addition of poly-aspartate or poly-glutamate also disperses DNA and actin-containing bundles in CF sputum and lowers the elastic moduli of these samples to levels comparable to those obtained after treatment with DNase I or gelsolin.	Polyglutamic Acid	30-44	gelsolin	Homo sapiens	224-232
15585265-1	2005	Polyelectrolyte multilayer films made of poly (L-lysine) (PLL) and poly (L-glutamic acid) (PGA) have been functionalized by covalent binding of a synthetic analogue of the anti-inflammatory peptide, alpha-melanocyte-stimulating hormone (alpha-MSH) to PGA to create biologically active coatings for tracheal prostheses.	Polyglutamic Acid	67-89	proopiomelanocortin	Rattus norvegicus	199-235
15807618-1	2005	We show, in this paper that multivalent ferrocyanide anions can penetrate into exponentially growing (PGA/PAH)n multilayer films whatever the nature of the last deposited layer.	Polyglutamic Acid	102-105	phenylalanine hydroxylase	Homo sapiens	106-109
15709201-1	2005	Pemetrexed is a novel antifolate with polyglutamate derivatives that are potent inhibitors of thymidylate synthase (TS) and to a lesser extent glycinamide ribonucleotide formyltransferase (GARFT).	Polyglutamic Acid	38-51	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	143-187
15542523-1	2004	BACKGROUND: Folylpoly-gamma-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates.	Polyglutamic Acid	140-154	folylpolyglutamate synthase	Homo sapiens	12-48
15542523-1	2004	BACKGROUND: Folylpoly-gamma-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates.	Polyglutamic Acid	140-154	folylpolyglutamate synthase	Homo sapiens	50-54
15546209-7	2004	PG-Hex-DTPA-Gd, obtained from aminohexyl-substituted PG and DTPA-dianhydride, was partially cross-linked and was undegradable in the presence of cathepsin B.	Polyglutamic Acid	0-2	hematopoietically expressed homeobox	Mus musculus	3-6
15546209-7	2004	PG-Hex-DTPA-Gd, obtained from aminohexyl-substituted PG and DTPA-dianhydride, was partially cross-linked and was undegradable in the presence of cathepsin B.	Polyglutamic Acid	0-2	cathepsin B	Mus musculus	145-156
14660571-9	2004	Amino acid substitutions in an acidic, polyglutamate motif within gastrin-17, the main bioactive, cellular gastrin form, did not alter secretion per se, but when these residues were substituted in C-terminally truncated mutants, double mutants increased in basal secretion and did not respond to secretagogue stimulation.	Polyglutamic Acid	39-52	gastrin	Homo sapiens	66-73
14702347-3	2004	A-SREBP-1 consists of the dimerization domain of B-SREBP-1 and a polyglutamic acid sequence that replaces the basic region.	Polyglutamic Acid	65-82	sterol regulatory element binding transcription factor 1	Homo sapiens	2-9
15047700-12	2004	Hence, consistent with the mono- and polyglutamate folate exporter function of BCRP, down-regulation of BCRP and increased folylpoly-gamma-glutamate synthetase activity appear to be crucial components of cellular adaptation to folate deficiency conditions.	Polyglutamic Acid	37-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-83
14627546-7	2004	A special feature of Tox is that the encoded protein sequence contains two poly-glutamic acid (poly E) stretches, which make Tox highly acidic.	Polyglutamic Acid	75-93	thymocyte selection-associated high mobility group box	Mus musculus	21-24
14627546-7	2004	A special feature of Tox is that the encoded protein sequence contains two poly-glutamic acid (poly E) stretches, which make Tox highly acidic.	Polyglutamic Acid	75-93	thymocyte selection-associated high mobility group box	Mus musculus	125-128
14500392-10	2003	Although transport gradually decreased as the polyglutamate chain length increased, both MTX-Glu(2) and MTX-Glu(3) were substrates for BCRP.	Polyglutamic Acid	46-59	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	135-139
14556233-1	2003	Glutamate carboxypeptidase II (EC 3.4.17.21) catalyzes the hydrolysis (Km = 0.2 microM) of the neuropeptide N-acetylaspartylglutamate to yield N-acetylaspartate and glutamate and also serves as a high-affinity folate hydrolase in the gut, cleaving the polyglutamate chain to permit the absorption of folate.	Polyglutamic Acid	252-265	folate hydrolase 1	Mus musculus	0-29
14734682-14	2004	Increase in tumor uptake of the nonspecific PEGylated protein (111)In-DTPA-PEG-ovalbumin was also observed after poly(L-glutamic acid)-paclitaxel treatment (55.6%), although this increase was less than that observed for (111)In-DTPA-PEG-annexin V (96.7%).	Polyglutamic Acid	113-134	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	79-88
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Polyglutamic Acid	83-97	folylpolyglutamate synthase	Homo sapiens	122-158
12874005-13	2003	These results indicate that ABCG2 is a component of the energy-dependent efflux system for certain folates and antifolates, but that its transport characteristics with respect to polyglutamates and reduced folates are not identical to those of multidrug resistance protein family members.	Polyglutamic Acid	179-193	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
12365000-7	2002	The poly-L-glutamate formulation was effective in two different muscle groups in mice at various plasmid doses for several transgenes, including an erythropoietin (EPO) gene, for which expression was elevated four- to 12-fold in comparison to animals that received EPO plasmid in saline.	Polyglutamic Acid	4-20	erythropoietin	Mus musculus	148-162
12365000-7	2002	The poly-L-glutamate formulation was effective in two different muscle groups in mice at various plasmid doses for several transgenes, including an erythropoietin (EPO) gene, for which expression was elevated four- to 12-fold in comparison to animals that received EPO plasmid in saline.	Polyglutamic Acid	4-20	erythropoietin	Mus musculus	164-167
12365000-7	2002	The poly-L-glutamate formulation was effective in two different muscle groups in mice at various plasmid doses for several transgenes, including an erythropoietin (EPO) gene, for which expression was elevated four- to 12-fold in comparison to animals that received EPO plasmid in saline.	Polyglutamic Acid	4-20	erythropoietin	Mus musculus	265-268
11751827-1	2002	We have constructed synthetic coding sequences for the expression of poly(alpha,L-glutamic acid) (PLGA) as fusion proteins with dihydrofolate reductase (DHFR) in Escherichia coli.	Polyglutamic Acid	69-96	Dihydrofolate reductase	Escherichia coli	128-151
11451495-0	2001	Controlled release of clot-dissolving tissue-type plasminogen activator from a poly(L-glutamic acid) semi-interpenetrating polymer network hydrogel.	Polyglutamic Acid	79-100	plasminogen activator, tissue type	Homo sapiens	38-71
11451495-1	2001	With the aim of developing an effective therapeutic modality for treatment of thrombosis, a tissue-type plasminogen activator (t-PA)-loaded porous poly(L-glutamic acid) (PLGA) semi-interpenetrating polymer network (semi-IPN) hydrogel was developed as a possible local drug delivery system.	Polyglutamic Acid	147-168	plasminogen activator, tissue type	Homo sapiens	92-125
11451495-1	2001	With the aim of developing an effective therapeutic modality for treatment of thrombosis, a tissue-type plasminogen activator (t-PA)-loaded porous poly(L-glutamic acid) (PLGA) semi-interpenetrating polymer network (semi-IPN) hydrogel was developed as a possible local drug delivery system.	Polyglutamic Acid	147-168	plasminogen activator, tissue type	Homo sapiens	127-131
11267657-11	2001	Mouse SK1 also exhibits novel, strain-specific, length polymorphism of a polyglutamate repeat in the N-terminal cytoplasmic domain.	Polyglutamic Acid	73-86	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	Mus musculus	6-9
10785518-5	2000	The protein sequence of hamster BSP displayed 86% amino acid identity with a consensus mammalian BSP sequence and retained polyglutamate sequences, the RGD sequence and sites of phosphorylation, glycosylation and sulphation.	Polyglutamic Acid	123-136	bone sialoprotein 2	Mesocricetus auratus	32-35
10861758-4	2000	PSM is a glutamate exocarboxypeptidase capable of cleaving the terminal alpha-linked glutamate from the dipeptide N-acetyl-aspartyl-glutamate (NAAG) and the gamma-linked glutamates from folate polyglutamate.	Polyglutamic Acid	193-206	folate hydrolase 1	Homo sapiens	0-3
12637007-1	2003	Spectral data indicate that polyglutamate chain lengths equal or greater than eight monomer units significantly change the apparent pK(a) for the alkaline transition of cytochrome c.	Polyglutamic Acid	28-41	cytochrome c, somatic	Equus caballus	169-181
12637007-5	2003	The rate constant for cyanide binding to the heme iron of cytochrome c of cytochrome c-polyglutamate complex also decreases by approximately 42.5% with n>or approximately equal 8.	Polyglutamic Acid	87-100	cytochrome c, somatic	Equus caballus	58-70
12637007-5	2003	The rate constant for cyanide binding to the heme iron of cytochrome c of cytochrome c-polyglutamate complex also decreases by approximately 42.5% with n>or approximately equal 8.	Polyglutamic Acid	87-100	cytochrome c, somatic	Equus caballus	74-86
12637007-8	2003	The results indicate that the polyglutamate (n>or approximately equal 8) is able to increase the stability of the methionine sulfur-heme iron bond of cytochrome c in spite of structural differences that weaken the overall stability of the cyt c at neutral and slightly alkaline pH.	Polyglutamic Acid	30-43	cytochrome c, somatic	Equus caballus	153-165
12502373-1	2003	Poly-alpha-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in aqueous solution at neutral pH, and were potent antitumor agents in vivo.	Polyglutamic Acid	0-28	choline phosphotransferase 1	Homo sapiens	71-74
12502373-1	2003	Poly-alpha-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in aqueous solution at neutral pH, and were potent antitumor agents in vivo.	Polyglutamic Acid	0-28	choline phosphotransferase 1	Homo sapiens	126-129
12502373-1	2003	Poly-alpha-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in aqueous solution at neutral pH, and were potent antitumor agents in vivo.	Polyglutamic Acid	30-32	choline phosphotransferase 1	Homo sapiens	71-74
12502373-1	2003	Poly-alpha-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in aqueous solution at neutral pH, and were potent antitumor agents in vivo.	Polyglutamic Acid	30-32	choline phosphotransferase 1	Homo sapiens	126-129
12514270-2	2003	Before absorption, these polyglutamates must be deconjugated to monoglutamates by the enzyme folylpoly-gamma-glutamate carboxypeptidase (FGCP), which is located in the jejunum.	Polyglutamic Acid	25-39	folate hydrolase 1	Homo sapiens	93-135
12514270-2	2003	Before absorption, these polyglutamates must be deconjugated to monoglutamates by the enzyme folylpoly-gamma-glutamate carboxypeptidase (FGCP), which is located in the jejunum.	Polyglutamic Acid	25-39	folate hydrolase 1	Homo sapiens	137-141
12114448-5	2002	Parameters estimated from fitting a series of hypothetical mathematical models to the data revealed that the experimental data were best fit by a model where GGH simultaneously cleaved multiple glutamyl residues, with highest activity at cleaving the outermost or two outermost residues from a polyglutamate chain.	Polyglutamic Acid	294-307	gamma-glutamyl hydrolase	Homo sapiens	158-161
12114448-6	2002	The model also revealed that GGH has a higher affinity for longer chain polyglutamates.	Polyglutamic Acid	72-86	gamma-glutamyl hydrolase	Homo sapiens	29-32
11063567-6	2000	The crystal structure of a close analogue of the inactive form of murine cytoplasmic SHMT (cSHMT), lacking only the polyglutamate tail of the inhibitor, has been determined to 2.9 A resolution.	Polyglutamic Acid	116-129	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	85-89
10777665-4	2000	Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine.	Polyglutamic Acid	51-68	neuronal guanine nucleotide exchange factor	Homo sapiens	0-4
10739875-2	2000	gamma-Glutamyl hydrolase (GH, EC 3.4.19.9) is a lysosomal and secreted glycoprotein that hydrolyzes the gamma-glutamyl tail of antifolate and folate polyglutamates.	Polyglutamic Acid	149-163	gamma-glutamyl hydrolase	Homo sapiens	0-24
10739875-2	2000	gamma-Glutamyl hydrolase (GH, EC 3.4.19.9) is a lysosomal and secreted glycoprotein that hydrolyzes the gamma-glutamyl tail of antifolate and folate polyglutamates.	Polyglutamic Acid	149-163	gamma-glutamyl hydrolase	Homo sapiens	26-28
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Polyglutamic Acid	83-97	folylpolyglutamate synthase	Homo sapiens	160-164
10507318-7	1999	These results indicate that FPGS mRNA expression may predict cellular ability to produce polyglutamate metabolites of antifolate drugs in the sensitive cells, but does not necessarily reflect FPGS function at the enzyme level in the antifolate-resistant tumor cells.	Polyglutamic Acid	89-102	folylpolyglutamate synthase	Homo sapiens	28-32
10395731-1	1999	10-Formyltetrahydrofolate dehydrogenase has previously been identified as a tight binding protein of the polyglutamate forms of tetrahydrofolate (R. J. Cook and C. Wagner, Biochemistry 21, 4427-4434, 1982).	Polyglutamic Acid	105-118	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-39
10413425-2	1999	These drugs are converted intracellularly into polyglutamate derivatives by the enzyme folylpolyglutamyl synthetase (FPGS).	Polyglutamic Acid	47-60	folylpolyglutamate synthase	Homo sapiens	87-115
10413425-2	1999	These drugs are converted intracellularly into polyglutamate derivatives by the enzyme folylpolyglutamyl synthetase (FPGS).	Polyglutamic Acid	47-60	folylpolyglutamate synthase	Homo sapiens	117-121
9753439-0	1998	Thermodynamic analysis of the binding of the polyglutamate chain of 5-formyltetrahydropteroylpolyglutamates to serine hydroxymethyltransferase.	Polyglutamic Acid	45-58	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	111-142
10363967-2	1999	Evidence for MRP-mediated antifolate efflux relies upon the following findings: (a) a 2-3.3-fold lower accumulation of [3H]MTX and subsequent reduced formation of long-chain polyglutamate forms of MTX; (b) reversal of MTX resistance by probenecid in both transfectants, and (c) ATP-dependent uptake of [3H]MTX in inside-out vesicles of MRP1 and MRP2 transfectants.	Polyglutamic Acid	174-187	ATP binding cassette subfamily C member 1	Homo sapiens	13-16
10092873-12	1999	These data suggest an important function of the polyglutamic acid tract in the process of association and dissociation of 5"-nucleotidase subunits.	Polyglutamic Acid	48-65	5'-nucleotidase ecto	Homo sapiens	122-137
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Polyglutamic Acid	224-238	gamma-glutamyl hydrolase	Mus musculus	12-36
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Polyglutamic Acid	224-238	gamma-glutamyl hydrolase	Mus musculus	38-40
10759428-9	1999	In combination, the hydroxyapatite-binding polyglutamic acid sequences and the RGD provide bi-functional entities through which BSP may mediate the targeting and attachment of normal and metastasizing cells to the bone surface.	Polyglutamic Acid	43-60	integrin binding sialoprotein	Homo sapiens	128-131
9385449-1	1997	According to spectral data the midtransition temperature of the cleavage of the sulfur-iron bond was 57.4 +/- 0.5 degrees C and 66.8 +/- 0.5 degrees C for cytochrome c and cytochrome c-polyglutamate complex, respectively.	Polyglutamic Acid	185-198	cytochrome c, somatic	Homo sapiens	172-184
9677387-13	1998	Binding to brain microtubules is suspected to occur via polyglutamates that are added post-translationally to tubulin in brain, which was shown to contain very low levels of FTCD, but not to tubulin in liver, which was determined to be the richest tissue source, by far, of FTCD.	Polyglutamic Acid	56-70	formimidoyltransferase cyclodeaminase	Rattus norvegicus	174-178
9677387-13	1998	Binding to brain microtubules is suspected to occur via polyglutamates that are added post-translationally to tubulin in brain, which was shown to contain very low levels of FTCD, but not to tubulin in liver, which was determined to be the richest tissue source, by far, of FTCD.	Polyglutamic Acid	56-70	formimidoyltransferase cyclodeaminase	Rattus norvegicus	274-278
9762351-3	1998	The polyglutamates of LY231514 inhibit at least three key folate enzymes: TS, DHFR, and GARFT, and to a lesser extent AICARFT and C1-tetrahydrofolate synthase.	Polyglutamic Acid	4-18	dihydrofolate reductase	Homo sapiens	78-82
9762351-3	1998	The polyglutamates of LY231514 inhibit at least three key folate enzymes: TS, DHFR, and GARFT, and to a lesser extent AICARFT and C1-tetrahydrofolate synthase.	Polyglutamic Acid	4-18	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	118-125
9385449-2	1997	Addition of polyglutamate to cytochrome c at pH 7.0 alters the denaturation properties of the protein.	Polyglutamic Acid	12-25	cytochrome c, somatic	Homo sapiens	29-41
9385449-3	1997	As follows from DSC scans, the denaturation temperature for cytochrome c is decreased from 85.4 +/- 0.2 degrees C to 68.7 +/- 0.2 degrees C in the presence of the saturated amount of polyglutamate.	Polyglutamic Acid	183-196	cytochrome c, somatic	Homo sapiens	60-72
9385449-4	1997	The protein stability in terms of Gibbs energy change at protein unfolding amount to delta G(25 degrees C) = 22.7 +/- 2.7 and 32.0 +/- 2.2 kJ/mol, for cytochrome c and cytochrome c-polyglutamate complex, respectively, at pH 7.0.	Polyglutamic Acid	181-194	cytochrome c, somatic	Homo sapiens	151-163
9385449-4	1997	The protein stability in terms of Gibbs energy change at protein unfolding amount to delta G(25 degrees C) = 22.7 +/- 2.7 and 32.0 +/- 2.2 kJ/mol, for cytochrome c and cytochrome c-polyglutamate complex, respectively, at pH 7.0.	Polyglutamic Acid	181-194	cytochrome c, somatic	Homo sapiens	168-180
9385449-5	1997	It is evident that polyglutamate increases the thermal stability of the sulfur-iron bond and decreases the denaturation temperature of the cytochrome c molecule as a whole.	Polyglutamic Acid	19-32	cytochrome c, somatic	Homo sapiens	139-151
9306433-4	1997	The ratio between GGH and FPGS activities was better at predicting the amount of polyglutamate accumulated in the 24-h [3H]MTX assay compared to the determination of either activity alone.	Polyglutamic Acid	81-94	gamma-glutamyl hydrolase	Homo sapiens	18-21
9295359-4	1997	Polyanions such as polyglutamate and double-stranded and single-stranded DNA bind to Cdc14p and affect its activity.	Polyglutamic Acid	19-32	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	85-91
9306433-4	1997	The ratio between GGH and FPGS activities was better at predicting the amount of polyglutamate accumulated in the 24-h [3H]MTX assay compared to the determination of either activity alone.	Polyglutamic Acid	81-94	folylpolyglutamate synthase	Homo sapiens	26-30
9306433-5	1997	The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001).	Polyglutamic Acid	71-85	gamma-glutamyl hydrolase	Homo sapiens	125-128
9306433-5	1997	The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001).	Polyglutamic Acid	71-85	folylpolyglutamate synthase	Homo sapiens	129-133
9306433-5	1997	The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001).	Polyglutamic Acid	92-106	gamma-glutamyl hydrolase	Homo sapiens	125-128
9306433-5	1997	The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001).	Polyglutamic Acid	92-106	folylpolyglutamate synthase	Homo sapiens	129-133
8954154-4	1996	Poly(glutamic acid) is able to compete fully with parathymosin for binding to histone H1, suggesting that this interaction is mediated by the acidic domain of the protein.	Polyglutamic Acid	0-19	parathymosin	Homo sapiens	50-62
8820948-5	1996	Polyglutamates became the predominant form of intracellular drug, both free in the cytosol and bound to dihydrofolate reductase, during a 24 h exposure to clinically achievable methotrexate concentrations.	Polyglutamic Acid	0-14	dihydrofolate reductase	Homo sapiens	104-127
10387997-5	1996	Polyglutamates became the predominant form of intracellular drug, both free in the cytosol and bound to dihydrofolate reductase, during a 24 h exposure to clinically achievable methotrexate concentrations.	Polyglutamic Acid	0-14	dihydrofolate reductase	Homo sapiens	104-127
7503769-4	1995	The present study demonstrated that insulin caused a decrease in the activity of gamma-glutamyl hydrolase (GH), the enzyme that degrades polyglutamates, that was inversely commensurate with the increase in the synthesis of MTX polyglutamates.	Polyglutamic Acid	137-151	gamma-glutamyl hydrolase	Rattus norvegicus	81-105
7503769-4	1995	The present study demonstrated that insulin caused a decrease in the activity of gamma-glutamyl hydrolase (GH), the enzyme that degrades polyglutamates, that was inversely commensurate with the increase in the synthesis of MTX polyglutamates.	Polyglutamic Acid	137-151	gamma-glutamyl hydrolase	Rattus norvegicus	107-109
7517720-1	1994	Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives.	Polyglutamic Acid	5-18	folylpolyglutamate synthase	Homo sapiens	31-35
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	Polyglutamic Acid	72-85	folylpolyglutamate synthase	Homo sapiens	101-137
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	Polyglutamic Acid	72-85	folylpolyglutamate synthase	Homo sapiens	139-143
7768066-5	1995	Some conserved features of the mature CgA protein are polyglutamic acids, calcium-binding sites, and several pairs of basic amino acids.	Polyglutamic Acid	54-72	chromogranin A	Homo sapiens	38-41
7918531-8	1994	Polyglutamate and phosvitin complexes of cytochrome c show changes in the circular dichroism spectrum similar to those observed with cytochrome c peroxidase.	Polyglutamic Acid	0-13	cytochrome c, somatic	Homo sapiens	41-53
7918531-8	1994	Polyglutamate and phosvitin complexes of cytochrome c show changes in the circular dichroism spectrum similar to those observed with cytochrome c peroxidase.	Polyglutamic Acid	0-13	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	133-156
7520695-0	1994	Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria.	Polyglutamic Acid	96-110	glycine decarboxylase	Homo sapiens	20-41
7495479-1	1995	Many quinazoline thymidylate synthase (TS) inhibitors undergo intracellular metabolism to polyglutamate forms which can significantly alter their activity and pharmacodynamics through improved TS inhibition and drug retention.	Polyglutamic Acid	90-103	thymidylate synthase	Mus musculus	17-37
7495480-1	1995	Quinazoline-based analogues of folic acid are a group of thymidylate synthase (TS) inhibitors that display a wide spectrum of activity for cultured tumour cells, partly due to their differential ability to form polyglutamate metabolites that are (i) more potent TS inhibitors and (ii) not readily effluxed from cells.	Polyglutamic Acid	211-224	thymidylate synthetase	Homo sapiens	57-77
7683570-4	1993	In addition, the resistant cells exhibit a severalfold increased activity of gamma-glutamyl hydrolase, the enzyme which cleaves the intracellular polyglutamate derivatives of the antifolates.	Polyglutamic Acid	146-159	gamma-glutamyl hydrolase	Rattus norvegicus	77-101
8144562-1	1994	Chinese hamster ovary (CHO) cells expressing human and Escherichia coli folylpolyglutamate synthetase (FPGS) activities were used as models to study factors regulating the cytotoxicity and metabolism of 5-deazaacyclotetrahydrofolate (DATHF), an anti-purine agent that requires conversion to polyglutamate forms to be a potent inhibitor of its target enzymes.	Polyglutamic Acid	77-90	folylpolyglutamate synthase	Homo sapiens	103-107
8278367-1	1994	Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat liver that binds 5-methyltetrahydrofolate polyglutamate in vivo.	Polyglutamic Acid	169-182	glycine N-methyltransferase	Rattus norvegicus	0-27
8278367-1	1994	Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat liver that binds 5-methyltetrahydrofolate polyglutamate in vivo.	Polyglutamic Acid	169-182	glycine N-methyltransferase	Rattus norvegicus	29-33
8278367-1	1994	Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat liver that binds 5-methyltetrahydrofolate polyglutamate in vivo.	Polyglutamic Acid	169-182	glycine N-methyltransferase	Rattus norvegicus	59-86
8408019-5	1993	Essentially all transported folate was metabolized to retained polyglutamate derivatives, the chain length of which varied with the level of FPGS activity.	Polyglutamic Acid	63-76	folylpolyglutamate synthase	Homo sapiens	141-145
8408021-4	1993	CHO cells expressing human FPGS metabolized MTX to polyglutamates characteristic of human cells.	Polyglutamic Acid	51-65	folylpolyglutamate synthase	Homo sapiens	27-31
8408021-5	1993	Cellular MTX accumulation and metabolism to polyglutamates were dependent on the level of FPGS activity and were unaffected by putative gamma-glutamyl hydrolase inhibitors.	Polyglutamic Acid	44-58	folylpolyglutamate synthase	Homo sapiens	90-94
8398636-7	1993	These schedules appear to be the most effective in the generation of the higher polyglutamates of 5,10-methylenetetrahydrofolate, the most efficient intracellular folate metabolite for ternary complex formation and TS inhibition.	Polyglutamic Acid	80-94	thymidylate synthetase	Homo sapiens	215-217
8195225-4	1994	When ionic interactions were neutralized without changing the ionic strength by addition of charged oligopeptides (polylysine and polyglutamic acid), stimulations of CYP1A2 and CYP2B4 reduction were observed.	Polyglutamic Acid	130-147	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	166-172
8195225-4	1994	When ionic interactions were neutralized without changing the ionic strength by addition of charged oligopeptides (polylysine and polyglutamic acid), stimulations of CYP1A2 and CYP2B4 reduction were observed.	Polyglutamic Acid	130-147	cytochrome P450 2B4	Oryctolagus cuniculus	177-183
7683570-5	1993	Evidence for the involvement of gamma-glutamyl hydrolase in resistance is derived from the observation that polyglutamate derivatives of 10-propargyl-5,8-dideazafolate in resistant cells are maintained at one-third the amount of that in parental cells in the presence of the same extracellular concentration.	Polyglutamic Acid	108-121	gamma-glutamyl hydrolase	Rattus norvegicus	32-56
7680647-10	1993	However, unlike cellular actin, poly-L glutamic acid was able to activate only 10% of the input RNP.	Polyglutamic Acid	32-52	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	96-99
7682074-2	1993	In the present report, studies are described examining the issue of methotrexate (MTX) polyglutamate retentiveness in cultured L1210 cells.	Polyglutamic Acid	87-100	metaxin 1	Mus musculus	82-85
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	78-81
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	90-93
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	90-93
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	74-81
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	90-93
7682074-3	1993	Measurements made in intact L1210 cells showed that the rate of egress of [3H]MTX and [3H]MTX+G1 was different depending upon whether [3H]-MTX and its polyglutamates were accumulated intracellularly following biosynthesis during growth (3 hr) in the presence of [3H]MTX or when cells were pulse loaded (5 min) with [3H]MTX or [3H]-MTX+G1 just prior to measurement of egress.	Polyglutamic Acid	151-165	metaxin 1	Mus musculus	90-93
8324932-4	1993	Since polyglutamates of methotrexate are direct inhibitors of thymidylate synthase and folate dependent enzymes of purine biosynthesis, the efficacy of this agent may involve blockade of these pathways.	Polyglutamic Acid	6-20	thymidylate synthetase	Homo sapiens	62-82
7679726-1	1993	Microtubule-associated protein (MAP) binding to assembled microtubules (MTs) can be reduced by the addition of polyglutamate without significant MT depolymerization or interference with MT elongation reactions.	Polyglutamic Acid	111-124	regulator of microtubule dynamics 1	Homo sapiens	0-30
7679726-1	1993	Microtubule-associated protein (MAP) binding to assembled microtubules (MTs) can be reduced by the addition of polyglutamate without significant MT depolymerization or interference with MT elongation reactions.	Polyglutamic Acid	111-124	regulator of microtubule dynamics 1	Homo sapiens	32-35
1282813-0	1992	Effect of cytochrome C oxidase and polyanions on the alkaline transition of ferricytochrome C. Application of heparin, polyadenylate, polyglutamate and polygalacturonate resulted in changes in the electron absorption spectrum of cytochrome c that resembled those after cytochrome c oxidase application at neutral pH.	Polyglutamic Acid	134-147	cytochrome c, somatic	Homo sapiens	10-22
7513935-7	1993	The importance of the metabolism of ICI D1694 to polyglutamates to its potent cytotoxic activity is demonstrated by compounds related in structure to ICI D1694 but with different properties for the RFC and FPGS.	Polyglutamic Acid	49-63	folylpolyglutamyl synthetase	Mus musculus	206-210
7680860-0	1993	The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.	Polyglutamic Acid	19-32	thymidylate synthase	Mus musculus	52-72
7680860-1	1993	A method is described for the measurement of the polyglutamates of the quinazoline thymidylate synthase inhibitor, N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin- 6-ylmethyl)-N-methylamino]-2-theonyl)-L-glutamic acid (ICI D1694).	Polyglutamic Acid	49-63	thymidylate synthase	Mus musculus	83-103
1282813-0	1992	Effect of cytochrome C oxidase and polyanions on the alkaline transition of ferricytochrome C. Application of heparin, polyadenylate, polyglutamate and polygalacturonate resulted in changes in the electron absorption spectrum of cytochrome c that resembled those after cytochrome c oxidase application at neutral pH.	Polyglutamic Acid	134-147	cytochrome c, somatic	Homo sapiens	229-241
1282813-0	1992	Effect of cytochrome C oxidase and polyanions on the alkaline transition of ferricytochrome C. Application of heparin, polyadenylate, polyglutamate and polygalacturonate resulted in changes in the electron absorption spectrum of cytochrome c that resembled those after cytochrome c oxidase application at neutral pH.	Polyglutamic Acid	134-147	cytochrome c, somatic	Homo sapiens	269-281
1429670-8	1992	The eIF-4 gamma polypeptide is 154 kDa (1396 amino acid residues) and contains sequence motifs of potential interest: a sequence (AGLGPR) that is similar to the substrate recognition sequence of protease 2A from rhinovirus serotype 14, five PEST regions with scores greater than 10, which are characteristic of rapidly degraded proteins, stretches of polyglutamic acid, and numerous potential phosphorylation sites.	Polyglutamic Acid	351-368	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	4-15
1379226-5	1992	In the present report, we show that the rate of turnover of MTX polyglutamates in lysosomes, which releases MTX in the extralysosomal space, is limited by the extent of mediated intralysosomal accumulation of the polyglutamate and reduced sulfhydryls that activate the enzyme folylpolyglutamate hydrolase.	Polyglutamic Acid	64-77	gamma-glutamyl hydrolase	Mus musculus	276-304
1435744-1	1992	Previous studies have documented the metabolism of a broad range of folate antimetabolites to polyglutamate derivatives by the enzyme folylpoly-gamma-glutamate synthetase (FPGS).	Polyglutamic Acid	94-107	folylpolyglutamate synthase	Homo sapiens	134-170
1435744-1	1992	Previous studies have documented the metabolism of a broad range of folate antimetabolites to polyglutamate derivatives by the enzyme folylpoly-gamma-glutamate synthetase (FPGS).	Polyglutamic Acid	94-107	folylpolyglutamate synthase	Homo sapiens	172-176
1379942-1	1992	Polyglutamate analogs of folate and related compounds were tested as inhibitors of casein kinase II (CK II) obtained from Xenopus laevis.	Polyglutamic Acid	0-13	casein kinase 2, alpha 1 polypeptide S homeolog	Xenopus laevis	83-99
1379942-1	1992	Polyglutamate analogs of folate and related compounds were tested as inhibitors of casein kinase II (CK II) obtained from Xenopus laevis.	Polyglutamic Acid	0-13	casein kinase 2, alpha 1 polypeptide S homeolog	Xenopus laevis	101-106
1729401-3	1992	We measured the tyrosine kinase activity in the cytosolic and membrane fraction using poly(glutamic acid:tyrosine, 4:1) as an artificial substrate.	Polyglutamic Acid	86-104	TXK tyrosine kinase	Homo sapiens	16-31
1442213-2	1992	BSP is characterized by the presence of several polyglutamic acid segments and an RGD motif that mediates cell attachment through a vitronectin-like receptor.	Polyglutamic Acid	48-65	integrin-binding sialoprotein	Rattus norvegicus	0-3
1494944-7	1992	The XNF-L was very similar to mouse NF-L, with a 77% sequence identity in the rod domain and the presence of a polyglutamic acid region in the tail domain, characteristic of type IV neurofilament proteins.	Polyglutamic Acid	111-128	neurofilament light chain L homeolog	Xenopus laevis	4-9
1525836-1	1992	The activity of gamma-glutamyl hydrolase, the enzyme which deglutamylates folyl and antifolyl polyglutamates, changed significantly in mouse cells during different phases of growth, being about two times lower in actively proliferating mice splenocytes and fibroblasts than in nondividing cells.	Polyglutamic Acid	94-108	gamma-glutamyl hydrolase	Mus musculus	16-40
1525836-4	1992	We suggest that gamma-glutamyl hydrolase is a proliferating dependent enzyme which together with folypolyglutamate synthetase ensures in cells an appropriate amount of folates in the form of polyglutamates necessary for optimizing folate-dependent biosynthetic activities.	Polyglutamic Acid	191-205	gamma-glutamyl hydrolase	Mus musculus	16-40
1557656-5	1992	Polyglutamate forms have a prolonged intracellular retention and a higher affinity for the target enzyme, thymidylate synthase.	Polyglutamic Acid	0-13	thymidylate synthetase	Homo sapiens	106-126
1372358-5	1992	As inhibitors of thymidylate synthase, these polyglutamates were more potent in every case than the corresponding non-polyglutamylated drug.	Polyglutamic Acid	45-59	thymidylate synthetase	Homo sapiens	17-37
2062852-3	1991	In addition this peptide competed with native phenylalanine hydroxylase for binding to 6,7-dimethyl-5,6,7,8-tetrahydropterin conjugated to a polyglutamate carrier.	Polyglutamic Acid	141-154	phenylalanine hydroxylase	Homo sapiens	46-71
1769968-14	1991	The mono(ADP-ribosyl)ation of p33 was markedly enhanced by polyanion, such as DNA, RNA, or poly(L-glutamate).	Polyglutamic Acid	91-107	leukocyte cell derived chemotaxin 2	Gallus gallus	30-33
2011593-2	1991	The kinase avidly phosphorylates synapsin I and contains a polyglutamate sequence, which suggests an association with chromatin as well.	Polyglutamic Acid	59-72	synapsin I	Rattus norvegicus	33-43
2044199-2	1991	wt polypeptide with anti-carcinogenic activity, was coupled to poly(D-lysine) (BBI-SS-PDL) and poly(L-glutamate) (BBI-SS-PLG) with a disulfide-cross-linking agent, N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP).	Polyglutamic Acid	95-112	plasminogen	Mus musculus	121-124
1832538-4	1991	Following 5-fluorouracil activation to 5-fluorodeoxyuridine monophosphates, its binding to thymidylate synthase is stabilized by the active cofactor, 5,10 methylene tetrahydrofolate and its polyglutamate forms.	Polyglutamic Acid	190-203	thymidylate synthetase	Homo sapiens	91-111
1993209-8	1991	The polyglutamate derivatives of DDATHF bound up to 100 times tighter to GARFT than DDATHF itself; longer chain polyglutamates conformed to Goldstein"s zone B behavior under experimental conditions and were projected to be in zone C, i.e., stoichiometric inhibition, in vivo.	Polyglutamic Acid	4-17	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	73-78
2914018-2	1989	The interaction of polyglutamates of [6R]CH2-H4PteGlu in the formation and stability of [6-3H]FdUMP-thymidylate synthase-CH2-H4PteGlun ternary complexes has therefore been examined using enzyme purified from a human colon adenocarcinoma xenograft.	Polyglutamic Acid	19-33	thymidylate synthetase	Homo sapiens	100-120
1691730-4	1990	A conjugate between adriamycin and murine IgGI monoclonal antibodies to human alpha-fetoprotein was prepared using a polyglutamic-acid bridge.	Polyglutamic Acid	117-134	alpha fetoprotein	Homo sapiens	78-95
2315962-5	1990	Pteroylpentaglutamate, the major endogenous polyglutamate form by chain length found to be present in MELC, afforded rapid and specific protection of URO synthase against lead inhibition.	Polyglutamic Acid	44-57	uroporphyrinogen III synthase	Mus musculus	150-162
35395477-3	2022	A ROS damage nanoamplifier (PT@PTGA) was fabricated using amphiphilic polyglutamic acid (PTGA) to load with a sonosensitizer (protoporphyrin IX, PpIX) and an MTH1 inhibitor (TH287).	Polyglutamic Acid	70-87	nudix hydrolase 1	Homo sapiens	158-162
2525127-3	1989	Treatment of the hepatoma cells with the reductase inhibitors for 72 h during growth caused approximately a 75% reduction in total cellular folates and 5,10-methylenetetrahydrofolate (primarily as polyglutamates) the substrate for thymidylate synthase.	Polyglutamic Acid	197-211	thymidylate synthetase	Homo sapiens	231-251
2525127-7	1989	These conditions predispose the target enzyme and the cells to more effective metabolic blockade by 10-propargyl-5,8-dideazafolate which is presumably caused by the formation of an inhibited 10-propargyl-5,8-dideazafolate[polyglutamate]-thymidylate synthase-dUMP ternary complex.	Polyglutamic Acid	222-235	thymidylate synthetase	Homo sapiens	237-257
2661484-4	1989	Resistance, de novo appears to be a consequence of relatively transient inhibition of the target enzyme thymidylate synthase (dTMP-synthase), which may be a consequence of low concentrations of 5,10-methylenetetrahydrofolate (CH2-H4PteGlu) or its polyglutamate forms within tumor cells in situ.	Polyglutamic Acid	247-260	thymidylate synthetase	Homo sapiens	104-124
2910471-5	1989	Tyrosine kinase activity was determined using poly(glutamic acid:tyrosine = 4:1) as an artificial substrate.	Polyglutamic Acid	46-64	TXK tyrosine kinase	Homo sapiens	0-15
2253202-7	1990	Furthermore, after incubation of CEM-FBP cells for 24 h at 10 nM [3H]ICI-198,583, the high affinity binding of the FBP for ICI-198,583 allowed a 600-fold concentrative uptake of [3H]ICI-198,583 and its conversion to polyglutamate forms.	Polyglutamic Acid	216-229	folate receptor alpha	Homo sapiens	37-40
2253202-7	1990	Furthermore, after incubation of CEM-FBP cells for 24 h at 10 nM [3H]ICI-198,583, the high affinity binding of the FBP for ICI-198,583 allowed a 600-fold concentrative uptake of [3H]ICI-198,583 and its conversion to polyglutamate forms.	Polyglutamic Acid	216-229	folate receptor alpha	Homo sapiens	115-118
29335199-0	2018	3-D mineralized silk fibroin/polycaprolactone composite scaffold modified with polyglutamate conjugated with BMP-2 peptide for bone tissue engineering.	Polyglutamic Acid	79-92	bone morphogenetic protein 2	Homo sapiens	109-114
2914018-10	1989	It would be advantageous for modulation of CH2-H4PteGlun pools to increase the concentrations of the longer polyglutamate species (n greater than or equal to 3) to maximize the interaction between FdUMP, thymidylate synthase and CH2-H4PteGlu.	Polyglutamic Acid	108-121	thymidylate synthetase	Homo sapiens	204-224
2521177-6	1989	Polyglutamates of HPteGlu, however, are more inhibitory to AICARFT, with HPteGlu4-6 having IC50 values close to 2 microM.	Polyglutamic Acid	0-14	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	59-66
2521177-8	1989	Polyglutamates of HPteGlu and of H4HPteGlu are poor inhibitors of SHMT (IC50, greater than 20 microM).	Polyglutamic Acid	0-14	serine hydroxymethyltransferase 1	Homo sapiens	66-70
3619447-11	1987	Comparison of MTX with its higher polyglutamates (MTX-Glu2 to MTX-Glu6) as FPGS substrates indicated a significant decrease in Vmax values with increasing glutamate chain length which was partially compensated for by a corresponding decrease in Km.	Polyglutamic Acid	34-48	folylpolyglutamate synthase	Homo sapiens	75-79
3664501-9	1987	TS inhibition increased as the polyglutamate chain length increased.	Polyglutamic Acid	31-44	thymidylate synthetase	Homo sapiens	0-2
2461200-0	1988	Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro.	Polyglutamic Acid	96-110	nuclear receptor subfamily 4, group A, member 1	Mus musculus	51-54
2461200-1	1988	The formation, retention and biological activity of the polyglutamate metabolites of the thymidylate synthase (TS) inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) has been investigated in L1210 murine leukaemia cells grown in vitro.	Polyglutamic Acid	56-69	thymidylate synthase	Mus musculus	89-109
2461200-1	1988	The formation, retention and biological activity of the polyglutamate metabolites of the thymidylate synthase (TS) inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) has been investigated in L1210 murine leukaemia cells grown in vitro.	Polyglutamic Acid	56-69	nuclear receptor subfamily 4, group A, member 1	Mus musculus	125-128
2461114-1	1988	A method is described herein for the isolation and quantitation of polyglutamates of the thymidylate synthase (TS) inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) in tumor cells exposed to the drug in vitro.	Polyglutamic Acid	67-81	thymidylate synthase	Mus musculus	89-109
2461114-1	1988	A method is described herein for the isolation and quantitation of polyglutamates of the thymidylate synthase (TS) inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) in tumor cells exposed to the drug in vitro.	Polyglutamic Acid	67-81	nuclear receptor subfamily 4, group A, member 1	Mus musculus	125-128
3365696-1	1988	The method for measuring polyglutamate forms of CH2-H4PteGlu and H4PteGlu, by entrapment in ternary complexes with [6-3H]5-fluoro-2"-deoxyuridylate and Lactobacillus casei thymidylate synthase has been characterized.	Polyglutamic Acid	25-38	thymidylate synthetase	Homo sapiens	172-192
2451560-9	1988	This conclusion is consistent with the proposition that the metabolism of slow-acting substrates for FPGS (such as 4-amino antifolates and their corresponding polyglutamates) may be sensitive to changes in enzyme levels or activity (Cook et al., Biochemistry, 26: 530-539, 1987).	Polyglutamic Acid	159-173	folylpolyglutamate synthase	Rattus norvegicus	101-105
2451560-11	1988	In contrast, when using the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid as the starting substrate under identical assay conditions, FPGS from extracts catalyzed the formation of predominantly long chain polyglutamate derivatives (Glu4 and higher).	Polyglutamic Acid	226-239	folylpolyglutamate synthase	Rattus norvegicus	155-159
2451560-12	1988	These results reflect the relative efficacy of methotrexate and N10-propargyl-5,8-dideazafolic acid, as well as their polyglutamate derivatives, as substrates for FPGS.	Polyglutamic Acid	118-131	folylpolyglutamate synthase	Rattus norvegicus	163-167
2828116-2	1988	A comparison of rat and bovine chromogranin A reveals similar features: clusters of polyglutamic acid, similar amino acid composition, position of seven of 10 pairs of basic amino acids, identical placement of the only two cysteine residues, a highly conserved N- and C-terminus, and a sequence homologous to porcine pancreastatin 1-49 [(1986) Nature 324, 476-478].	Polyglutamic Acid	84-101	chromogranin A	Bos taurus	31-45
2450690-5	1988	After discontinuation of MTX therapy, the ery-MTX declined in a non-linear manner because of different half-lives for the individual polyglutamates.	Polyglutamic Acid	133-147	metaxin 1	Homo sapiens	25-28
2450690-5	1988	After discontinuation of MTX therapy, the ery-MTX declined in a non-linear manner because of different half-lives for the individual polyglutamates.	Polyglutamic Acid	133-147	metaxin 1	Homo sapiens	46-49
2881781-2	1986	The predicted en protein contains a homeodomain and regions rich in polyalanine, polyglutamine, polyglutamate/aspartate and serine.	Polyglutamic Acid	96-109	engrailed	Drosophila melanogaster	14-16
2445177-8	1987	Thymidylate synthase shows small effects of Km and Vmax values, but the order of addition of substrates and of release of products is reversed with polyglutamate as compared with monoglutamate substrates.	Polyglutamic Acid	148-161	thymidylate synthetase	Sus scrofa	0-20
2445177-9	1987	Our studies with thymidylate synthase from L. casei have shown that the bacterial enzyme also exhibits a greatly increased affinity for polyglutamate vs. monoglutamate derivatives of folic acid, and that reversal in the order of substrate addition and product release also occurs with polyglutamate as compared with monoglutamate substrates.	Polyglutamic Acid	136-149	thymidylate synthetase	Sus scrofa	17-37
2445177-9	1987	Our studies with thymidylate synthase from L. casei have shown that the bacterial enzyme also exhibits a greatly increased affinity for polyglutamate vs. monoglutamate derivatives of folic acid, and that reversal in the order of substrate addition and product release also occurs with polyglutamate as compared with monoglutamate substrates.	Polyglutamic Acid	285-298	thymidylate synthetase	Sus scrofa	17-37
2445177-10	1987	We have also studied the polyglutamate specificity of methionine synthase, which is responsible for the conversion of CH3-H4PteGlu1 into H4PteGlu1.	Polyglutamic Acid	25-38	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	54-73
2884102-0	1987	Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals.	Polyglutamic Acid	36-53	nucleophosmin/nucleoplasmin 2 S homeolog	Xenopus laevis	0-13
2831173-3	1987	As it is well known that FBP"s preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP"s in these animals.	Polyglutamic Acid	64-78	far upstream element binding protein 1	Rattus norvegicus	25-28
2831173-3	1987	As it is well known that FBP"s preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP"s in these animals.	Polyglutamic Acid	64-78	far upstream element binding protein 1	Rattus norvegicus	218-221
2448654-2	1987	Polyglutamate derivatives of MTX bind to dihydrofolate reductase (DHFR) with affinities comparable to the monoglutamate, but their retention in cells results in a sustained block in tetrahydrofolate (FH4) synthesis.	Polyglutamic Acid	0-13	dihydrofolate reductase	Homo sapiens	41-64
2448654-2	1987	Polyglutamate derivatives of MTX bind to dihydrofolate reductase (DHFR) with affinities comparable to the monoglutamate, but their retention in cells results in a sustained block in tetrahydrofolate (FH4) synthesis.	Polyglutamic Acid	0-13	dihydrofolate reductase	Homo sapiens	66-70
3431589-7	1987	The ability of compounds to inhibit both DHFR and FPGS makes it possible in principle for such compounds to kill cells via a "self-potentiation" mechanism in which inhibition of tetrahydrofolate synthesis is complemented by interference with the subsequent conversion of tetrahydrofolates to their polyglutamate conjugates.	Polyglutamic Acid	298-311	dihydrofolate reductase	Homo sapiens	41-45
3431589-7	1987	The ability of compounds to inhibit both DHFR and FPGS makes it possible in principle for such compounds to kill cells via a "self-potentiation" mechanism in which inhibition of tetrahydrofolate synthesis is complemented by interference with the subsequent conversion of tetrahydrofolates to their polyglutamate conjugates.	Polyglutamic Acid	298-311	folylpolyglutamate synthase	Homo sapiens	50-54
2421732-7	1986	This low activity of the polyglutamyl derivatives of methotrexate for aldehyde oxidase is consistent with the observations that the predominant forms of 4-amino-antifolate polyglutamates found in human liver after administration of methotrexate are the polyglutamyl derivatives of the parent compound.	Polyglutamic Acid	172-186	aldehyde oxidase 1	Homo sapiens	70-86
3466358-1	1986	Chinese hamster AUX B1 cells lack the enzyme folylpolyglutamate synthetase (FPGS) responsible for adding polyglutamates to folic acid.	Polyglutamic Acid	105-119	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	45-74
3466358-1	1986	Chinese hamster AUX B1 cells lack the enzyme folylpolyglutamate synthetase (FPGS) responsible for adding polyglutamates to folic acid.	Polyglutamic Acid	105-119	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	76-80
3466358-8	1986	Transformants with FPGS activity that showed a human enzyme preference for dATP also had folate polyglutamate chain lengths characteristic of the human enzyme.	Polyglutamic Acid	96-109	folylpolyglutamate synthase	Homo sapiens	19-23
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Polyglutamic Acid	16-29	folylpolyglutamate synthase	Homo sapiens	42-46
3527705-7	1986	Although many properties of YCK-2 and LCK-2, including substrate specificity, inhibition by heparin, polyglutamic acid and quercetin and stimulation by polyamines, are similar; their stability under denaturing and dissociating conditions and their response to polybasic peptides are quite different.	Polyglutamic Acid	101-118	serine/threonine protein kinase YCK2	Saccharomyces cerevisiae S288C	28-33
2425449-5	1986	Replacing active concentrations of albumin by either reduced-carboxymethylated albumin, defatted albumin, plasmin-treated or thermolysin-treated albumin also caused an increase (50-130%) in thrombin binding, whereas replacement by acid-hydrolysed albumin or with polyglutamic acid was either ineffective or even inhibitory.	Polyglutamic Acid	263-280	prothrombin	Oryctolagus cuniculus	190-198
6201178-4	1984	The pattern of polyglutamate products synthesized by rat liver FPGS was nearly identical with both 7-hydroxymethotrexate and methotrexate.	Polyglutamic Acid	15-28	folylpolyglutamate synthase	Rattus norvegicus	63-67
3517565-0	1986	Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes.	Polyglutamic Acid	14-27	thymidylate synthetase	Homo sapiens	77-97
2410001-0	1985	Suppression of human alpha-foetoprotein-producing hepatocellular carcinoma growth in nude mice by an anti alpha-foetoprotein antibody-daunorubicin conjugate with a poly-L-glutamic acid derivative as intermediate drug carrier.	Polyglutamic Acid	164-184	alpha fetoprotein	Mus musculus	21-39
3873989-15	1985	In contrast to the formation of long-chain polyglutamates observed when tetrahydrofolate or folinic acid was the substrate, beef liver FPGS, under our reaction conditions, cannot catalyze the formation from MTX monoglutamate of polyglutamates longer than the triglutamate.	Polyglutamic Acid	43-57	folylpolyglutamate synthase	Homo sapiens	135-139
2414022-5	1985	Incubation of MCF-7 cells with 2.5 nM insulin for 48 h before exposure to 2 microM [3H]MTX for a further 24 h resulted in a significant increase in both total drug and total polyglutamates compared with control cells.	Polyglutamic Acid	174-188	insulin	Homo sapiens	38-45
2414022-6	1985	Increasing the insulin concentration in the medium yielded further increases in polyglutamylation so that at 250 nM insulin and above total polyglutamates were increased by 64% compared with control cells.	Polyglutamic Acid	140-154	insulin	Homo sapiens	15-22
2414022-7	1985	Further evaluation of the effects of physiologic insulin levels on polyglutamate synthesis revealed that 2.5 nM insulin caused an increase in the net glutamylation rate for each polyglutamate derivative during the final 12 h of a 24 h exposure to MTX.	Polyglutamic Acid	67-80	insulin	Homo sapiens	49-56
2414022-7	1985	Further evaluation of the effects of physiologic insulin levels on polyglutamate synthesis revealed that 2.5 nM insulin caused an increase in the net glutamylation rate for each polyglutamate derivative during the final 12 h of a 24 h exposure to MTX.	Polyglutamic Acid	67-80	insulin	Homo sapiens	112-119
2414022-7	1985	Further evaluation of the effects of physiologic insulin levels on polyglutamate synthesis revealed that 2.5 nM insulin caused an increase in the net glutamylation rate for each polyglutamate derivative during the final 12 h of a 24 h exposure to MTX.	Polyglutamic Acid	178-191	insulin	Homo sapiens	49-56
2414022-7	1985	Further evaluation of the effects of physiologic insulin levels on polyglutamate synthesis revealed that 2.5 nM insulin caused an increase in the net glutamylation rate for each polyglutamate derivative during the final 12 h of a 24 h exposure to MTX.	Polyglutamic Acid	178-191	insulin	Homo sapiens	112-119
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	38-51	insulin	Homo sapiens	27-34
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	38-51	dihydrofolate reductase	Homo sapiens	63-67
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	38-51	insulin	Homo sapiens	101-108
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	38-51	dihydrofolate reductase	Homo sapiens	174-178
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	156-170	insulin	Homo sapiens	27-34
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	156-170	dihydrofolate reductase	Homo sapiens	63-67
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	156-170	insulin	Homo sapiens	101-108
2414022-8	1985	Analysis of the effects of insulin on polyglutamate binding to DHFR revealed that exposure to 2.5 nM insulin resulted in the preferential binding of higher polyglutamates to DHFR.	Polyglutamic Acid	156-170	dihydrofolate reductase	Homo sapiens	174-178
2414022-9	1985	In MDA-231 cells, a breast cancer cell line with a poor capacity for polyglutamate synthesis, insulin exposure resulted in an increase in the cellular accumulation of each polyglutamate derivative, with the greatest proportionate increases occurring in the cellular levels of higher polyglutamates.	Polyglutamic Acid	69-82	insulin	Homo sapiens	94-101
2414022-9	1985	In MDA-231 cells, a breast cancer cell line with a poor capacity for polyglutamate synthesis, insulin exposure resulted in an increase in the cellular accumulation of each polyglutamate derivative, with the greatest proportionate increases occurring in the cellular levels of higher polyglutamates.	Polyglutamic Acid	172-185	insulin	Homo sapiens	94-101
2414022-9	1985	In MDA-231 cells, a breast cancer cell line with a poor capacity for polyglutamate synthesis, insulin exposure resulted in an increase in the cellular accumulation of each polyglutamate derivative, with the greatest proportionate increases occurring in the cellular levels of higher polyglutamates.	Polyglutamic Acid	283-297	insulin	Homo sapiens	94-101
6239865-9	1984	Only polyglutamate was found to mimic the action of calmodulin.	Polyglutamic Acid	5-18	calmodulin 1	Rattus norvegicus	52-62
6208368-9	1984	Evidence is presented that polyglutamic acid facilitates the nucleosome spacing activity of histone H5, primarily by keeping the nucleoprotein soluble.	Polyglutamic Acid	27-44	H1 histone family, member 0	Gallus gallus	92-102
4066660-2	1985	Formiminotransferase-cyclodeaminase, a circular tetramer of dimers, binds four tetrahydropteroylpolyglutamates/octamer, which indicates that these polyglutamate sites are formed by one type of subunit interface.	Polyglutamic Acid	96-109	formimidoyltransferase cyclodeaminase	Homo sapiens	0-35
6085013-0	1984	Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver.	Polyglutamic Acid	15-28	thymidylate synthetase	Sus scrofa	44-64
6206272-0	1984	An anti-alpha-fetoprotein antibody-daunorubicin conjugate with a novel poly-L-glutamic acid derivative as intermediate drug carrier.	Polyglutamic Acid	71-91	alpha-fetoprotein	Rattus norvegicus	8-25
6325341-11	1984	The LDCL responses which were induced by mixtures of PARG and concanavalin A were also strongly inhibited by mannose, alpha-methyl mannoside, and poly-L-glutamic acid.	Polyglutamic Acid	146-166	poly(ADP-ribose) glycohydrolase	Homo sapiens	53-57
6546690-5	1984	Hence, the increased dose of mAPA-HCysA required to inhibit tumor growth in vitro and in vivo relative to methotrexate may reflect, in part, the inability of this compound to form non-effluxing polyglutamates.	Polyglutamic Acid	194-208	glutamyl aminopeptidase	Mus musculus	29-33
6838652-2	1983	In order to explain the difference of inhibition of dihydrofolate reductase (DHFR) by methotrexate (MTX) and its metabolites 7-hydroxymethotrexate [7OH (MTX)] and polyglutamate derivatives [MTX (G1) and MTX (G2)], direct determinations of binding parameters to beef liver DHFR were performed.	Polyglutamic Acid	163-176	dihydrofolate reductase	Homo sapiens	52-75
6193143-11	1983	These experiments demonstrated that the longer chain polyglutamates have prolonged intracellular retention and can be dissociated less readily than MTX-Glu2 from DHFR, properties likely to make them more efficient DHFR inhibitors than the parent drug and of potential importance in extending the duration of drug action in tumor cells.	Polyglutamic Acid	53-67	dihydrofolate reductase	Homo sapiens	162-166
6193143-11	1983	These experiments demonstrated that the longer chain polyglutamates have prolonged intracellular retention and can be dissociated less readily than MTX-Glu2 from DHFR, properties likely to make them more efficient DHFR inhibitors than the parent drug and of potential importance in extending the duration of drug action in tumor cells.	Polyglutamic Acid	53-67	dihydrofolate reductase	Homo sapiens	214-218
6838652-2	1983	In order to explain the difference of inhibition of dihydrofolate reductase (DHFR) by methotrexate (MTX) and its metabolites 7-hydroxymethotrexate [7OH (MTX)] and polyglutamate derivatives [MTX (G1) and MTX (G2)], direct determinations of binding parameters to beef liver DHFR were performed.	Polyglutamic Acid	163-176	dihydrofolate reductase	Homo sapiens	77-81
4122-2	1976	The activity of a partially purified preparation of tyrosine hydroxylase (EC 1.14.16.2) from the bovine caudate nucleus was increased by heparin, chondroitin sulfate, phosphatidylserine, polyacrylic acid, polyvinyl sulfuric acid and both poly-D-, and poly-L-glutamic acids, all polyanions.	Polyglutamic Acid	251-272	tyrosine hydroxylase	Bos taurus	52-72
6193690-6	1983	However, preincubation with methotrexate and GAT permits continued synthesis and accumulation of polyglutamates so that when the GAT and methotrexate were removed, toxicity from the retained methotrexate polyglutamates could be expressed.	Polyglutamic Acid	97-111	glycine-N-acyltransferase	Homo sapiens	45-48
6193690-6	1983	However, preincubation with methotrexate and GAT permits continued synthesis and accumulation of polyglutamates so that when the GAT and methotrexate were removed, toxicity from the retained methotrexate polyglutamates could be expressed.	Polyglutamic Acid	97-111	glycine-N-acyltransferase	Homo sapiens	129-132
7051769-0	1982	Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues.	Polyglutamic Acid	112-125	methylenetetrahydrofolate reductase	Homo sapiens	14-49
7051769-7	1982	Methylenetetrahydrofolate reductase is inhibited by dihydrofolate and its polyglutamate analogues.	Polyglutamic Acid	74-87	methylenetetrahydrofolate reductase	Homo sapiens	0-35
666858-0	1978	The effect of vitamin B12 inhibition in vivo: impaired folate polyglutamate biosynthesis indicating that 5-methyltetrahydropteroylglutamate is not its usual substrate.	Polyglutamic Acid	62-75	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
640715-2	1978	The binding of C1q to Fc piece, small molecular weight (less than 10,000) dextran sulphate, polyglutamic acid and polylysine have value; for the functional affinity constant (Ko) in the range of 0.2-1.5 X 10(4) M-1.	Polyglutamic Acid	92-109	complement C1q A chain	Homo sapiens	15-18
6180291-13	1982	However, co-incubation in MTX plus GAT resulted in the accumulation of polyglutamates and a sustained inhibition of cell growth and DNA synthesis upon removal of both MTX and GAT from the culture medium.	Polyglutamic Acid	71-85	glycine-N-acyltransferase	Homo sapiens	35-38
6165589-0	1981	Effect of anti-Lyb3 antiserum on poly (L-glutamic acid, L-lysine)-induced B cell tolerance.	Polyglutamic Acid	33-54	B-lymphocyte antigen 3	Mus musculus	15-19
1247496-5	1976	The failure of folate polyglutamate synthesis in ivtamin B12 deficiency arises either from a failure to provide the proper substrate for polyglutamate synthesis or to a direct requirement for vitamin B12 for polyglutamate synthesis.	Polyglutamic Acid	22-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
32924641-0	2020	The pH-triggered polyglutamate brush co-delivery of MDR1 and survivin-targeting siRNAs efficiently overcomes multi-drug resistance of NSCLC.	Polyglutamic Acid	17-30	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
1247496-3	1976	In contrast to the fall in red cell polyglutamate concentration in vitamin B12 deficiency, there was a marked fall in short-chain folates in early folate deficiency (treated non-anaemic epileptics) and a fall in both short chain and long chain polyglutamates in patients with severe folate deficiency and megaloblastic anaemia.	Polyglutamic Acid	36-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Polyglutamic Acid	83-103	acid phosphatase 2, lysosomal	Bos taurus	146-172
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Polyglutamic Acid	83-103	beta-glucuronidase	Bos taurus	174-192
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Polyglutamic Acid	83-103	cathepsin D	Bos taurus	198-209
33676231-5	2021	We find that the C-terminal poly-glutamic acid tract (poly-E) and a 30-residue insertion in MYND domain (M-insertion), which are unique to SMYD5, regulate the structural stability.	Polyglutamic Acid	28-46	SMYD family member 5	Homo sapiens	139-144
33517814-0	2021	Are long-chain methotrexate polyglutamate levels the reason for LD-MTX related adverse events in inflammatory arthritis?	Polyglutamic Acid	28-41	metaxin 1	Homo sapiens	67-70
31954730-5	2020	The nanogels were fabricated using host-guest interactions between azobenzene (Azo) and beta-cyclodextrin (betaCD) conjugated to poly (L-glutamic acid)-graft-poly (ethylene glycol) methyl ether (PLG-g-mPEG).	Polyglutamic Acid	129-151	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	88-114
32834257-3	2020	Owing to the electrostatic interaction between the negatively charged components (i.e., PGA and MSN) and positively charged amino acids of the epitope of EV71 capsid protein VP2 (VP2-ep), the obtained microfibers strongly adsorbed the epitope, and exhibited high EV71-adsorption capacity.	Polyglutamic Acid	88-91	vp2-ep	None	179-185
32155998-5	2020	A modified BMP-2 mimetic peptide containing a negatively charged poly-glutamic acid residue (E7 BMP-2 peptide) was used to bind positively charged hydroxyapatite (HA) particles by electrostatic attraction.	Polyglutamic Acid	65-83	bone morphogenetic protein 2	Homo sapiens	11-16
31691161-6	2020	Herein, the angiogenic growth factor Vascular Endothelial Growth Factor (VEGF) is complexed electrostatically with star-shaped or linear polyglutamic acid (PGA) polypeptides.	Polyglutamic Acid	137-154	vascular endothelial growth factor A	Homo sapiens	37-71
31691161-6	2020	Herein, the angiogenic growth factor Vascular Endothelial Growth Factor (VEGF) is complexed electrostatically with star-shaped or linear polyglutamic acid (PGA) polypeptides.	Polyglutamic Acid	137-154	vascular endothelial growth factor A	Homo sapiens	73-77
31691161-6	2020	Herein, the angiogenic growth factor Vascular Endothelial Growth Factor (VEGF) is complexed electrostatically with star-shaped or linear polyglutamic acid (PGA) polypeptides.	Polyglutamic Acid	156-159	vascular endothelial growth factor A	Homo sapiens	37-71
31691161-6	2020	Herein, the angiogenic growth factor Vascular Endothelial Growth Factor (VEGF) is complexed electrostatically with star-shaped or linear polyglutamic acid (PGA) polypeptides.	Polyglutamic Acid	156-159	vascular endothelial growth factor A	Homo sapiens	73-77
31691161-7	2020	Optimised PGA-VEGF nanomedicines provide VEGF encapsulation of > 99% and facilitate sustained release of VEGF for up to 28 days in vitro.	Polyglutamic Acid	10-13	vascular endothelial growth factor A	Homo sapiens	14-18
31691161-7	2020	Optimised PGA-VEGF nanomedicines provide VEGF encapsulation of > 99% and facilitate sustained release of VEGF for up to 28 days in vitro.	Polyglutamic Acid	10-13	vascular endothelial growth factor A	Homo sapiens	41-45
31691161-11	2020	Therefore, we report the development of novel, self-assembling PGA-VEGF nanomedicines and their incorporation into a hyaluronic acid hydrogel that is compatible with medical devices to enable minimally invasive delivery to the heart.	Polyglutamic Acid	63-66	vascular endothelial growth factor A	Homo sapiens	67-71
31611592-7	2020	FPGS rs1544105 and GGH -401C > T SNPs influenced the polyglutamate levels.	Polyglutamic Acid	53-66	gamma-glutamyl hydrolase	Homo sapiens	19-22
32155998-5	2020	A modified BMP-2 mimetic peptide containing a negatively charged poly-glutamic acid residue (E7 BMP-2 peptide) was used to bind positively charged hydroxyapatite (HA) particles by electrostatic attraction.	Polyglutamic Acid	65-83	bone morphogenetic protein 2	Homo sapiens	96-101
32029842-0	2020	Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate.	Polyglutamic Acid	74-87	steroidogenic acute regulatory protein	Homo sapiens	62-66
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	94-107	steroidogenic acute regulatory protein	Homo sapiens	82-86
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	94-107	tumor necrosis factor	Homo sapiens	217-225
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	94-107	TNF superfamily member 12	Homo sapiens	211-216
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	94-107	interferon gamma	Homo sapiens	226-234
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	109-112	steroidogenic acute regulatory protein	Homo sapiens	82-86
31422020-4	2019	FEZ1 contains multiple acidic, poly-glutamate stretches that interact with the positively charged central pore of CA hexamers.	Polyglutamic Acid	31-45	fasciculation and elongation protein zeta 1	Homo sapiens	0-4
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	109-112	TNF superfamily member 12	Homo sapiens	211-216
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	109-112	tumor necrosis factor	Homo sapiens	217-225
32029842-4	2020	Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition.	Polyglutamic Acid	109-112	interferon gamma	Homo sapiens	226-234
31408258-4	2019	Specifically, VEGF-derived "QK" peptides were synthesized with polyglutamate domains containing varying numbers of glutamates.	Polyglutamic Acid	63-76	vascular endothelial growth factor A	Homo sapiens	14-18
31603707-1	2019	ATP/GTP binding protein like 1 (AGBL1) plays a role in controlling the length of polyglutamate side chains.	Polyglutamic Acid	81-94	AGBL carboxypeptidase 1	Homo sapiens	0-30
31603707-1	2019	ATP/GTP binding protein like 1 (AGBL1) plays a role in controlling the length of polyglutamate side chains.	Polyglutamic Acid	81-94	AGBL carboxypeptidase 1	Homo sapiens	32-37
31285604-3	2019	Here, we present a ~3.2 A resolution cryo-EM structure of the Drosophila melanogaster spastin hexamer with a polyglutamate peptide bound in its central pore.	Polyglutamic Acid	109-122	spastin	Drosophila melanogaster	86-93
31405005-8	2019	Based on these observations, PGlu could serve as an alternative to heparin in the regenerative therapy of bone using BMP-2.	Polyglutamic Acid	29-33	bone morphogenetic protein 2	Mus musculus	117-122
30815757-0	2019	Polyglutamic Acid Functionalization of Chitosan Nanoparticles Enhances the Therapeutic Efficacy of Insulin Following Oral Administration.	Polyglutamic Acid	0-17	insulin	Homo sapiens	99-106
31380170-0	2019	PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l-Glutamic Acid)-Combretastatin A4 Conjugate in Metastatic Breast Cancer.	Polyglutamic Acid	59-80	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	0-9
31380170-2	2019	Poly(l-glutamic acid)-combretastatin A4 conjugate (PLG-CA4) is a novel class of VDAs.	Polyglutamic Acid	0-21	carbonic anhydrase 4	Mus musculus	55-58
30942216-2	2019	Here we report a delivery vehicle achieved by encapsulating red fluorescent protein (RFP) within chitosan (CS), which can simultaneously deliver engineered Cas9 RNPs with a poly-glutamate peptide tag (E-tag) and DNA donors into a range of cell types with high genome editing efficacy and non-cytotoxicity.	Polyglutamic Acid	173-187	tripartite motif containing 27	Homo sapiens	60-83
30942216-2	2019	Here we report a delivery vehicle achieved by encapsulating red fluorescent protein (RFP) within chitosan (CS), which can simultaneously deliver engineered Cas9 RNPs with a poly-glutamate peptide tag (E-tag) and DNA donors into a range of cell types with high genome editing efficacy and non-cytotoxicity.	Polyglutamic Acid	173-187	tripartite motif containing 27	Homo sapiens	85-88
30680816-4	2019	An effective VDA nanomedicine of poly(l-glutamic acid)-graft-methoxy poly(ethylene glycol)/combretastatin A4 (CA4-NPs) is prepared and can selectively enhance tumor hypoxia and boost a typical HAP tirapazamine (TPZ) therapy against metastatic 4T1 breast tumors.	Polyglutamic Acid	33-54	carbonic anhydrase 4	Mus musculus	110-113
31117440-2	2019	Herein, we developed camptothecin (CPT)-conjugated prodrug (CPTP) micelles in which CPT was grafted to the poly(ethylene glycol)-poly(glutamic acid) block copolymer via a disulfide bond linker for a redox-triggered drug release.	Polyglutamic Acid	129-148	ceramide-1-phosphate transfer protein	Homo sapiens	60-64
30766790-0	2019	Interaction between human serum albumin and cholesterol-grafted polyglutamate as the potential carriers of protein drugs.	Polyglutamic Acid	64-77	albumin	Homo sapiens	26-39
30457584-0	2019	Cerebrospinal fluid levels of alpha-synuclein measured using a poly-glutamic acid-modified gold nanoparticle-doped disposable neuro-biosensor system.	Polyglutamic Acid	63-81	synuclein alpha	Homo sapiens	30-45
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	Polyglutamic Acid	42-59	synuclein alpha	Homo sapiens	155-170
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	Polyglutamic Acid	42-59	synuclein alpha	Homo sapiens	172-181
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	Polyglutamic Acid	61-64	synuclein alpha	Homo sapiens	155-170
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	Polyglutamic Acid	61-64	synuclein alpha	Homo sapiens	172-181
30766790-3	2019	In this study, we synthesized cholesterol-grafted polyglutamate (PGA-g-Chol) as a hydrophobically-modified polypeptide, and thoroughly characterized its interaction with a model protein (human serum albumin) in the aqueous solution by using circular dichroism, fluorescence methods, and light scattering.	Polyglutamic Acid	50-63	albumin	Homo sapiens	193-206
30098571-3	2018	Herein, amphiphilic block copolymer radiosensitizers are prepared from clinically approved poly(ethylene glycol)-block-poly(l-glutamic acid) (PEG-b-PLG) and metronidazole (MN) to obtain MN-grafted PEG-b-PLG (PEG-b-P(LG-g-MN)) via condensation reaction, which can self-assemble into core-shell micelles as nanoparticle-formulated radiosensitizers in aqueous solution.	Polyglutamic Acid	119-140	plasminogen	Homo sapiens	148-151
30427196-0	2018	beta2-Type Amyloidlike Fibrils of Poly-l-glutamic Acid Convert into Long, Highly Ordered Helices upon Dissolution in Dimethyl Sulfoxide.	Polyglutamic Acid	34-54	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
30427196-4	2018	Here, we investigate an unusual DMSO-induced conformational transition of beta2-amyloid fibrils from poly-l-glutamic acid (PLGA).	Polyglutamic Acid	101-121	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-79
30538465-5	2018	Materials and methods: In this study, we constructed a safe and efficient anticancer drug delivery system PGA-Asp-maleimide-cisplatin-peptide complex (PAMCP), which was loaded with CDDP and conjugated with the transferrin receptor (TFR)-targeting peptide through a maleimide functional linker.	Polyglutamic Acid	106-109	transferrin receptor	Mus musculus	210-230
30538465-5	2018	Materials and methods: In this study, we constructed a safe and efficient anticancer drug delivery system PGA-Asp-maleimide-cisplatin-peptide complex (PAMCP), which was loaded with CDDP and conjugated with the transferrin receptor (TFR)-targeting peptide through a maleimide functional linker.	Polyglutamic Acid	106-109	transferrin receptor	Mus musculus	232-235
29326243-3	2018	This article addresses the impact of PCFT on concentrative transport, critical to the formation of the active polyglutamate congeners, and at pH levels relevant to the tumor microenvironment.	Polyglutamic Acid	110-123	solute carrier family 46 member 1	Homo sapiens	37-41
30094655-11	2018	A MWCNT-poly(glutamic acid) nanocomposite was used as a biocompatible matrix for MUC1-aptamer immobilization.	Polyglutamic Acid	8-27	mucin 1, cell surface associated	Homo sapiens	81-85
32104392-2	2018	A novel macromolecular conjugate of CA4 (CA4-PL) was synthesized by covalent bonding of CA4 onto poly(L-glutamic acid)-graft-polyethylene glycol (PLG-g-PEG) via Yamaguchi reaction.	Polyglutamic Acid	97-118	carbonic anhydrase 4	Homo sapiens	36-39
32104392-2	2018	A novel macromolecular conjugate of CA4 (CA4-PL) was synthesized by covalent bonding of CA4 onto poly(L-glutamic acid)-graft-polyethylene glycol (PLG-g-PEG) via Yamaguchi reaction.	Polyglutamic Acid	97-118	carbonic anhydrase 4	Homo sapiens	41-47
32104392-2	2018	A novel macromolecular conjugate of CA4 (CA4-PL) was synthesized by covalent bonding of CA4 onto poly(L-glutamic acid)-graft-polyethylene glycol (PLG-g-PEG) via Yamaguchi reaction.	Polyglutamic Acid	97-118	carbonic anhydrase 4	Homo sapiens	41-44
30175347-3	2018	In this study, we developed a poly(l-glutamic acid)-based (PLGA-based) shape memory porous scaffold by cross-linking PLGA with poly(epsilon-caprolactone)-diols (PCL-diols) and by using the particle leaching method.	Polyglutamic Acid	30-51	PHD finger protein 1	Homo sapiens	161-164
28167300-4	2017	In this study, we proposed a poly(l-glutamic acid)-CA4 conjugate (PLG-CA4) nanomedicine to fulfill the requirements for fully liberating the potential of CA4 on tumor therapy.	Polyglutamic Acid	29-50	carbonic anhydrase 4	Mus musculus	51-54
29127003-0	2018	Recombinant alpha-fetoprotein receptor-binding domain co-expression with polyglutamate tags facilitates in vivo folding in E. coli.	Polyglutamic Acid	73-86	alpha fetoprotein	Homo sapiens	12-29
29143139-3	2017	Pretreatments with alternate soaking process (ASP) using solutions containing calcium ions and phosphate ions followed by incubation with SBF for 24 h resulted in HAp deposition on PS plates with adsorption layers of HSA, type I collagen, hen egg white lysozyme, and poly L-glutamic acid, an acidic protein analogue: the deposition behaviors were correlated with adsorption ability and charge state of proteins.	Polyglutamic Acid	267-287	BAG cochaperone 1	Homo sapiens	163-166
28548819-6	2017	In contrast, PGA and PMA capsules show high cellular association toward phagocytic Raw 264.7 and THP-1 cells.	Polyglutamic Acid	13-16	GLI family zinc finger 2	Homo sapiens	97-102
28214608-2	2017	To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate (1-PG) made from a new phthalocyanine (Pc 1) monofunctionalized to allow adequate conjugation to PGA.	Polyglutamic Acid	57-77	minisatellite 6 hypermutable	Mus musculus	127-131
28167300-4	2017	In this study, we proposed a poly(l-glutamic acid)-CA4 conjugate (PLG-CA4) nanomedicine to fulfill the requirements for fully liberating the potential of CA4 on tumor therapy.	Polyglutamic Acid	29-50	carbonic anhydrase 4	Mus musculus	70-73
28167300-4	2017	In this study, we proposed a poly(l-glutamic acid)-CA4 conjugate (PLG-CA4) nanomedicine to fulfill the requirements for fully liberating the potential of CA4 on tumor therapy.	Polyglutamic Acid	29-50	carbonic anhydrase 4	Mus musculus	70-73
26909651-0	2016	Beware of Cocktails: Chain-Length Bidispersity Triggers Explosive Self-Assembly of Poly-L-Glutamic Acid beta2-Fibrils.	Polyglutamic Acid	83-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	104-109
28219007-6	2017	In contrast, the EndoIII mutants E200K, Y205H, and K208E, which provide electrostatic perturbations in the vicinity of the cluster, all show DNA-free potentials within error of wild type; similarly, the presence of negatively charged poly-l-glutamate does not lead to a significant potential shift.	Polyglutamic Acid	234-250	endonuclease III	Escherichia coli	17-24
28159518-4	2017	Here, we describe the design, synthesis, physico-chemical characterization and the biological evaluation of an NCAM-targeted conjugate of polyglutamic acid with paclitaxel that was developed and evaluated on neuroblastoma, a high NCAM-expressing tumor.	Polyglutamic Acid	138-155	neural cell adhesion molecule 1	Homo sapiens	111-115
28159518-4	2017	Here, we describe the design, synthesis, physico-chemical characterization and the biological evaluation of an NCAM-targeted conjugate of polyglutamic acid with paclitaxel that was developed and evaluated on neuroblastoma, a high NCAM-expressing tumor.	Polyglutamic Acid	138-155	neural cell adhesion molecule 1	Homo sapiens	230-234
28029105-4	2017	Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B.	Polyglutamic Acid	24-27	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	55-58
28029105-4	2017	Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B.	Polyglutamic Acid	24-27	cathepsin B	Homo sapiens	141-152
28128286-3	2017	CCP1) defines the 6-member cytosolic carboxypeptidase (CCP) family that metabolizes polyglutamate side chain and its loss results in neurodegeneration and male infertility.	Polyglutamic Acid	84-97	ATP/GTP binding protein 1	Mus musculus	0-4
27620954-10	2016	FPGS catalyzes the addition of a long polyglutamate chain to folates and antifolates, hence rendering them polyanions which are efficiently retained in the cell and are now bound with enhanced affinity by various folate-dependent enzymes.	Polyglutamic Acid	38-51	folylpolyglutamate synthase	Homo sapiens	0-4
26941104-3	2016	The mutational hotspot in RPGR(ORF15)is an unusual C-terminal domain encoded by exon ORF15, which is rich in polyglutamates and glycine residues (Glu-Gly domain) followed by a short stretch of basic amino acid residues (RPGR(C2)domain; residues 1072-1152).	Polyglutamic Acid	109-123	retinitis pigmentosa GTPase regulator	Mus musculus	26-36
27099990-2	2016	Poly(glutamic acid) at low pH self-assembles after incubation at higher temperature into fibrils composed of antiparallel sheets that are stacked in a beta2-type structure whose amide carbonyls have bifurcated H-bonds involving the side chains from the next sheet.	Polyglutamic Acid	0-19	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	151-156
26280363-3	2015	TFPI microspheres were made of a TFPI plasmid which was enwrapped by poly-l-glutamic acid (PLGA).	Polyglutamic Acid	69-89	tissue factor pathway inhibitor	Oryctolagus cuniculus	0-4
27301173-1	2016	A series of novel polypeptide-based graft copolymer poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) was synthesized through a Steglich esterification reaction of PLG with mPEG.	Polyglutamic Acid	52-73	plasminogen	Homo sapiens	185-188
27144051-2	2016	Huntington"s disease is caused by a polyglutamate expansion of the protein huntingtin.	Polyglutamic Acid	36-49	huntingtin	Homo sapiens	75-85
27301173-1	2016	A series of novel polypeptide-based graft copolymer poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) was synthesized through a Steglich esterification reaction of PLG with mPEG.	Polyglutamic Acid	52-73	plasminogen	Homo sapiens	111-114
26280363-3	2015	TFPI microspheres were made of a TFPI plasmid which was enwrapped by poly-l-glutamic acid (PLGA).	Polyglutamic Acid	69-89	tissue factor pathway inhibitor	Oryctolagus cuniculus	33-37
26176902-0	2015	Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials.	Polyglutamic Acid	85-98	bone morphogenetic protein 2	Bos taurus	108-112
26278169-0	2015	Interfacial electron transfer of glucose oxidase on poly(glutamic acid)-modified glassy carbon electrode and glucose sensing.	Polyglutamic Acid	52-71	hydroxyacid oxidase 1	Homo sapiens	33-48
26278169-1	2015	The interfacial electron transfer of glucose oxidase (GOx) on a poly(glutamic acid)-modified glassy carbon electrode (PGA/GCE) was investigated.	Polyglutamic Acid	64-83	hydroxyacid oxidase 1	Homo sapiens	37-52
26278169-1	2015	The interfacial electron transfer of glucose oxidase (GOx) on a poly(glutamic acid)-modified glassy carbon electrode (PGA/GCE) was investigated.	Polyglutamic Acid	64-83	hydroxyacid oxidase 1	Homo sapiens	54-57
26362583-1	2015	Poly-L-glutamic acid (PLGA) forms amyloid-like beta2-fibrils with the main spectral component of vibrational amide I" band unusually shifted below 1600 cm(-1).	Polyglutamic Acid	0-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	47-52