PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23230278-5 2013 The salient finding of this study, revealed via gel-based LC-MS/MS, was the exclusive identification in EpCAM-Exos of the classical apical trafficking molecules CD63 (LAMP3), mucin 13 and the apical intestinal enzyme sucrase isomaltase and increased expression of dipeptidyl peptidase IV and the apically restricted pentaspan membrane glycoprotein prominin 1. Hydroxyethyl Starch Derivatives 316-325 epithelial cell adhesion molecule Homo sapiens 104-109 23741323-12 2013 Resuscitation with HTS and HES, especially HES can reduce lung injury after hemorrhagic shock, partly by up-regulating the expressions of aquaporin1 and aquaporin5. Hydroxyethyl Starch Derivatives 27-30 aquaporin 1 Rattus norvegicus 138-148 23741323-12 2013 Resuscitation with HTS and HES, especially HES can reduce lung injury after hemorrhagic shock, partly by up-regulating the expressions of aquaporin1 and aquaporin5. Hydroxyethyl Starch Derivatives 27-30 aquaporin 5 Rattus norvegicus 153-163 23741323-12 2013 Resuscitation with HTS and HES, especially HES can reduce lung injury after hemorrhagic shock, partly by up-regulating the expressions of aquaporin1 and aquaporin5. Hydroxyethyl Starch Derivatives 43-46 aquaporin 1 Rattus norvegicus 138-148 23741323-12 2013 Resuscitation with HTS and HES, especially HES can reduce lung injury after hemorrhagic shock, partly by up-regulating the expressions of aquaporin1 and aquaporin5. Hydroxyethyl Starch Derivatives 43-46 aquaporin 5 Rattus norvegicus 153-163 23881659-15 2013 The RR of AKI based on RIFLE-F (failure) criteria also showed an increased risk of AKI in individuals treated with HES products (RR 1.14, 95% CI 1.01 to 1.30; 15 studies, 8402 participants). Hydroxyethyl Starch Derivatives 115-118 ribonucleotide reductase catalytic subunit M1 Homo sapiens 129-133 23312901-7 2013 AF4 and QCM results show a rapid degradation for HES with lower degrees of hydroxyethylation. Hydroxyethyl Starch Derivatives 49-52 immunoglobulin kappa variable 4-80 Mus musculus 0-3 23230278-5 2013 The salient finding of this study, revealed via gel-based LC-MS/MS, was the exclusive identification in EpCAM-Exos of the classical apical trafficking molecules CD63 (LAMP3), mucin 13 and the apical intestinal enzyme sucrase isomaltase and increased expression of dipeptidyl peptidase IV and the apically restricted pentaspan membrane glycoprotein prominin 1. Hydroxyethyl Starch Derivatives 316-325 CD63 molecule Homo sapiens 161-165 23161076-1 2013 A pentaspan membrane glycoprotein prominin-1 (frequently called CD133 in human) is widely used as a surface marker to identify and isolate normal stem/progenitor cells from various organs, although it is also expressed in some types of differentiated cells. Hydroxyethyl Starch Derivatives 2-11 prominin 1 Homo sapiens 34-44 23150174-1 2013 The pentaspan protein CD133 (Prominin-1) is part of the signature of tumour-initiating cells for various cancer entities. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Homo sapiens 22-27 23150174-1 2013 The pentaspan protein CD133 (Prominin-1) is part of the signature of tumour-initiating cells for various cancer entities. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Homo sapiens 29-39 23161076-1 2013 A pentaspan membrane glycoprotein prominin-1 (frequently called CD133 in human) is widely used as a surface marker to identify and isolate normal stem/progenitor cells from various organs, although it is also expressed in some types of differentiated cells. Hydroxyethyl Starch Derivatives 2-11 prominin 1 Homo sapiens 64-69 23383572-3 2012 Thus, we devised a method of preparing leukocyte-rich plasma (LRP) using hydroxyethyl starch (HES) in order to improve the endotoxin assay. Hydroxyethyl Starch Derivatives 94-97 protein tyrosine phosphatase receptor type A Homo sapiens 39-60 23326490-1 2013 The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Felis catus 57-67 23383572-3 2012 Thus, we devised a method of preparing leukocyte-rich plasma (LRP) using hydroxyethyl starch (HES) in order to improve the endotoxin assay. Hydroxyethyl Starch Derivatives 94-97 protein tyrosine phosphatase receptor type A Homo sapiens 62-65 23084749-1 2012 The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor cells and is associated with poor prognosis in a number of tumor types. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Homo sapiens 36-41 19617247-8 2010 RESULTS: On average and across all photo-optical methods, fibrinogen concentrations were overestimated, particularly with HES-200. Hydroxyethyl Starch Derivatives 122-125 fibrinogen beta chain Homo sapiens 58-68 22777109-9 2012 Meanwhile, the hematocrit levels of the HbV, Alb, and HES groups showed sharp decreases (HbV: 6.8% +- 1.7%, Alb: 6.8% +- 0.8%, HES: 5.5% +- 0.7% at 100% total circulated blood volume; final hematocrit of the HbV group: 1.5% +- 0.5%). Hydroxyethyl Starch Derivatives 54-57 albumin Rattus norvegicus 108-111 22777109-9 2012 Meanwhile, the hematocrit levels of the HbV, Alb, and HES groups showed sharp decreases (HbV: 6.8% +- 1.7%, Alb: 6.8% +- 0.8%, HES: 5.5% +- 0.7% at 100% total circulated blood volume; final hematocrit of the HbV group: 1.5% +- 0.5%). Hydroxyethyl Starch Derivatives 127-130 albumin Rattus norvegicus 45-48 22784287-7 2012 Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS. Hydroxyethyl Starch Derivatives 52-55 tumor necrosis factor Homo sapiens 141-150 22784287-7 2012 Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS. Hydroxyethyl Starch Derivatives 52-55 interleukin 1 beta Homo sapiens 152-161 22784287-7 2012 Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS. Hydroxyethyl Starch Derivatives 52-55 interleukin 6 Homo sapiens 164-168 22784287-7 2012 Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS. Hydroxyethyl Starch Derivatives 52-55 interleukin 10 Homo sapiens 190-195 21415432-4 2011 In this study, we examined the possible involvement of TLR4 signaling in the antiinflammatory effects of HES. Hydroxyethyl Starch Derivatives 105-108 toll-like receptor 4 Rattus norvegicus 55-59 21415432-10 2011 Molecular analysis showed that both 15 and 30 mL/kg HES significantly decreased TLR4 mRNA levels and inhibited activation of p38 MAPK and AP-1 in rats challenged with LPS, whereas activation of extracellular signal-regulated kinases 1/2 MAPK was not affected by either dose of HES. Hydroxyethyl Starch Derivatives 52-55 toll-like receptor 4 Rattus norvegicus 80-84 21415432-10 2011 Molecular analysis showed that both 15 and 30 mL/kg HES significantly decreased TLR4 mRNA levels and inhibited activation of p38 MAPK and AP-1 in rats challenged with LPS, whereas activation of extracellular signal-regulated kinases 1/2 MAPK was not affected by either dose of HES. Hydroxyethyl Starch Derivatives 52-55 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 138-142 21415432-11 2011 CONCLUSIONS: These findings indicate that the beneficial effects of HES 130/0.4 on inflammation are mediated at least in part by inhibiting the TLR4/p38 MAPK/AP-1 pathway in lungs from rats challenged with LPS. Hydroxyethyl Starch Derivatives 68-71 toll-like receptor 4 Rattus norvegicus 144-148 21415432-11 2011 CONCLUSIONS: These findings indicate that the beneficial effects of HES 130/0.4 on inflammation are mediated at least in part by inhibiting the TLR4/p38 MAPK/AP-1 pathway in lungs from rats challenged with LPS. Hydroxyethyl Starch Derivatives 68-71 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 158-162 20558004-8 2010 Albumin-creatinine ratio per % burn (ACR, a marker of capillary leak) was lower in the HES-supplemented group at 12h after burn (p=0.0310). Hydroxyethyl Starch Derivatives 87-90 acrosin Homo sapiens 37-40 22170377-5 2012 In this article we describe findings that the addition of HES lowered the amounts of three deglycosylating enzymes needed for remodeling GCR. Hydroxyethyl Starch Derivatives 58-61 glucosylceramidase beta Homo sapiens 137-140 22170377-8 2012 The thermal stability of both GCR and alpha-glucosidase were enhanced by HES as both molecules showed an increased transition midpoint (T(m)). Hydroxyethyl Starch Derivatives 73-76 glucosylceramidase beta Homo sapiens 30-33 22170377-8 2012 The thermal stability of both GCR and alpha-glucosidase were enhanced by HES as both molecules showed an increased transition midpoint (T(m)). Hydroxyethyl Starch Derivatives 73-76 sucrase-isomaltase Homo sapiens 38-55 21273030-7 2011 On unadjusted Cox regression, patients in the highest quintile of cumulative pentastarch administration had a higher rate of mortality compared with those receiving no colloid (hazard ratio, 3.8; 95% confidence interval, 1.2-12.4; P = .03). Hydroxyethyl Starch Derivatives 77-88 cytochrome c oxidase subunit 8A Homo sapiens 14-17 21740798-9 2011 C-reactive protein (CRP) was significantly lower in the HES group compared with the other groups. Hydroxyethyl Starch Derivatives 56-59 C-reactive protein Homo sapiens 0-18 21740798-9 2011 C-reactive protein (CRP) was significantly lower in the HES group compared with the other groups. Hydroxyethyl Starch Derivatives 56-59 C-reactive protein Homo sapiens 20-23 19617247-0 2010 Influence of different hydroxyethyl starch (HES) formulations on fibrinogen measurement in HES-diluted plasma. Hydroxyethyl Starch Derivatives 44-47 fibrinogen beta chain Homo sapiens 65-75 19617247-0 2010 Influence of different hydroxyethyl starch (HES) formulations on fibrinogen measurement in HES-diluted plasma. Hydroxyethyl Starch Derivatives 91-94 fibrinogen beta chain Homo sapiens 65-75 19617247-13 2010 CONCLUSIONS: The study showed that all HES solutions more or less impaired the fibrinogen measurement with the photo-optical method. Hydroxyethyl Starch Derivatives 39-42 fibrinogen beta chain Homo sapiens 79-89 20056447-11 2010 The HES-containing priming solution induced the largest decrease in the maximum clot firmness attributed to fibrinogen, from 13 +/- 1 mm (baseline) to 6 +/- 1 mm (p < 0.01 v baseline). Hydroxyethyl Starch Derivatives 4-7 fibrinogen beta chain Homo sapiens 108-118 20451670-8 2010 Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain. Hydroxyethyl Starch Derivatives 11-14 tumor necrosis factor Rattus norvegicus 42-51 20451670-8 2010 Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain. Hydroxyethyl Starch Derivatives 11-14 interleukin 6 Rattus norvegicus 53-57 20451670-8 2010 Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain. Hydroxyethyl Starch Derivatives 11-14 intercellular adhesion molecule 1 Rattus norvegicus 63-69 20451670-8 2010 Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain. Hydroxyethyl Starch Derivatives 11-14 toll-like receptor 2 Rattus norvegicus 124-128 20451670-8 2010 Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain. Hydroxyethyl Starch Derivatives 11-14 toll-like receptor 4 Rattus norvegicus 133-137 20056447-12 2010 CONCLUSIONS: All studied priming solutions prolonged coagulation time and decreased clot formation, but the fibrinogen-limiting effect was the most profound for the HES-containing priming solution. Hydroxyethyl Starch Derivatives 165-168 fibrinogen beta chain Homo sapiens 108-118 19886839-6 2009 The CCR5-59029 AG genotype was significantly higher in the HES compared with the HSP group (57.44% vs. 37.24%, p = 0.014). Hydroxyethyl Starch Derivatives 59-62 C-C motif chemokine receptor 5 Homo sapiens 4-8 20623980-2 2010 While HES application the average arterial pressure after induction into anesthesia was less pronounced and concentration of C-reactive protein on the third postoperative day was lesser. Hydroxyethyl Starch Derivatives 6-9 C-reactive protein Homo sapiens 125-143 19825916-3 2010 RESULTS: Group HES and GEL had significantly prolonged PT and aPTT, decreased VIII:C and vWF immediately after AHFI. Hydroxyethyl Starch Derivatives 15-18 cytochrome c oxidase subunit 8A Homo sapiens 78-82 19825916-3 2010 RESULTS: Group HES and GEL had significantly prolonged PT and aPTT, decreased VIII:C and vWF immediately after AHFI. Hydroxyethyl Starch Derivatives 15-18 von Willebrand factor Homo sapiens 89-92 19825916-6 2010 CONCLUSION: Gelatin reduced clot quality associated with derangements of fibrin polymerization and HES 130/0.4 delayed initiation of sufficient thrombin generation to convert fibrinogen to fibrin and impaired platelet function. Hydroxyethyl Starch Derivatives 99-102 coagulation factor II, thrombin Homo sapiens 144-152 20122930-1 2010 Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. Hydroxyethyl Starch Derivatives 48-57 prominin 1 Homo sapiens 0-10 20122930-1 2010 Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. Hydroxyethyl Starch Derivatives 48-57 prominin 1 Homo sapiens 12-17 19910630-9 2010 In the presence of 2% and 4% HES 200/0.5 in 98% (96%) medium over a stimulation time period of 10 h and 18 h, the MCP-1 concentration was decreased between 26% and 56% (P < 0.05). Hydroxyethyl Starch Derivatives 29-32 C-C motif chemokine ligand 2 Homo sapiens 114-119 19910630-10 2010 TNF-alpha stimulation resulted in a significant decrease of viability by 53%-63%, whereas viability decreased by only 32%-40% in coincubation with HES 130/0.42 (P < 0.005) and remained even less affected by TNF-alpha in the presence of HES 200/0.5 (P < 0.001). Hydroxyethyl Starch Derivatives 239-242 tumor necrosis factor Homo sapiens 0-9 19910630-11 2010 The TNF-alpha-induced cell death rate was attenuated in the presence of HES 200/0.5 (P < 0.05). Hydroxyethyl Starch Derivatives 72-75 tumor necrosis factor Homo sapiens 4-13 19935110-3 2010 We assessed the effects of hypertonic saline, mannitol, and HES solutions on platelet CD40L expression. Hydroxyethyl Starch Derivatives 60-63 CD40 ligand Homo sapiens 86-91 19935110-7 2010 RESULTS: Preconditioning of platelet-rich plasma with hypertonic saline, mannitol, and HES attenuated CD40L expression at dilution ratios of 5%, 1%, and 1%, respectively. Hydroxyethyl Starch Derivatives 87-90 CD40 ligand Homo sapiens 102-107 19935110-9 2010 The effects of mannitol and HES on CD40L expression were almost identical and were superior to those of 3% saline. Hydroxyethyl Starch Derivatives 28-31 CD40 ligand Homo sapiens 35-40 19935110-11 2010 CONCLUSIONS: Our data show that resuscitation fluids, such as hypertonic saline, mannitol, and HES, inhibit agonist-induced CD40L expression on platelets. Hydroxyethyl Starch Derivatives 95-98 CD40 ligand Homo sapiens 124-129 19886839-9 2009 Gene-gene interaction studies showed enrichment of the CCR5-59029AG*CCL3L1>2 genotype in the HES group when compared with the HSP group (31.91% vs. 15.81%, p = 0.021, OR = 0.401, CI = 0.194-0.826). Hydroxyethyl Starch Derivatives 96-99 C-C motif chemokine receptor 5 Homo sapiens 55-59 19886839-9 2009 Gene-gene interaction studies showed enrichment of the CCR5-59029AG*CCL3L1>2 genotype in the HES group when compared with the HSP group (31.91% vs. 15.81%, p = 0.021, OR = 0.401, CI = 0.194-0.826). Hydroxyethyl Starch Derivatives 96-99 C-C motif chemokine ligand 3 like 1 Homo sapiens 68-74 19615133-20 2009 (4) The SP-C mRNA expression in LPS, NS, ALB and GEL groups were lower than that in control and HES groups (all P < 0.05), but there was no difference between control and HES groups (P > 0.05). Hydroxyethyl Starch Derivatives 96-99 surfactant protein C Rattus norvegicus 8-12 19114887-12 2009 Intraoperative fluid balance was lower in the HES group (Alb 23 [11-39] mL x kg; HES: 12 [-5-30] mL x kg; p = 0.005). Hydroxyethyl Starch Derivatives 46-49 albumin Homo sapiens 57-60 19142092-11 2009 RESULTS: In group S, the MPO levels were significantly increased in the reperfusion phase compared with baseline, whereas there was a decrease in MPO levels in the reperfusion period in the HES group. Hydroxyethyl Starch Derivatives 190-193 myeloperoxidase Oryctolagus cuniculus 146-149 20028511-7 2009 At 40% but not at 10% haemodilution rate, HES 200/0.5 also increased platelet fibrinogen binding and both HES solutions increased expression of CD62P, the main receptor for platelet-leukocyte adhesion. Hydroxyethyl Starch Derivatives 106-109 selectin P Homo sapiens 144-149 18819155-11 2008 Twenty patients had AE, being hypotension and catheter dysfunction the most frequent ones, while tachycardia, hypertension and paresthesias were statistically more frequent in the HES/albumin group. Hydroxyethyl Starch Derivatives 180-183 albumin Homo sapiens 184-191 18461021-5 2008 The percentage of CD4+ T cells decreased to 20% to 25%, and the ratio of T helper type 1 (TH1)/TH2 responses was significantly reduced in all TH/S rats, however, resuscitation with HES alone reversed the trends (49.4% +/- 9.7% vs. 55.2% +/- 2.6% in sham for CD4 T cells; 0.64 +/- 0.23 vs. 0.71 +/- 0.16 in sham for the ratio of TH1/TH2, P > 0.05 for both). Hydroxyethyl Starch Derivatives 181-184 Cd4 molecule Rattus norvegicus 18-21 18461021-5 2008 The percentage of CD4+ T cells decreased to 20% to 25%, and the ratio of T helper type 1 (TH1)/TH2 responses was significantly reduced in all TH/S rats, however, resuscitation with HES alone reversed the trends (49.4% +/- 9.7% vs. 55.2% +/- 2.6% in sham for CD4 T cells; 0.64 +/- 0.23 vs. 0.71 +/- 0.16 in sham for the ratio of TH1/TH2, P > 0.05 for both). Hydroxyethyl Starch Derivatives 181-184 Cd4 molecule Rattus norvegicus 258-261 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 15-18 Cd4 molecule Rattus norvegicus 49-52 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 15-18 albumin Rattus norvegicus 134-137 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 15-18 synaptotagmin 1 Rattus norvegicus 187-190 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 15-18 albumin Rattus norvegicus 134-137 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 93-96 albumin Rattus norvegicus 22-25 18461021-6 2008 Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation. Hydroxyethyl Starch Derivatives 93-96 albumin Rattus norvegicus 22-25 18461021-7 2008 These data demonstrated that HES resuscitation modulated the balance of TH1 and TH2 responses and inhibited TH/S-related nuclear factor-kappaB activation and CD4 T-cell apoptosis in TH/S rats. Hydroxyethyl Starch Derivatives 29-32 Cd4 molecule Rattus norvegicus 158-161 18498252-4 2008 HS induced dramatic EPO (erythropoietin) gene transcription, reaching a maximum at 4 h post-ET. Hydroxyethyl Starch Derivatives 0-2 erythropoietin Rattus norvegicus 20-23 18498252-4 2008 HS induced dramatic EPO (erythropoietin) gene transcription, reaching a maximum at 4 h post-ET. Hydroxyethyl Starch Derivatives 0-2 erythropoietin Rattus norvegicus 25-39 18633012-9 2008 In the early postoperative phase, HES 130/0.4 was found to exert significantly less effect on measures of coagulation, especially activated partial thromboplastin time and von Willebrand factor (antigen and ristocetin cofactor), than HES 200/0.5. Hydroxyethyl Starch Derivatives 34-37 von Willebrand factor Homo sapiens 172-193 18434912-10 2008 However, when HUVEC were cultured with 1.5% wt/vol HES, neutrophil capture induced by low-dose (1 unit/mL) tumor necrosis factor-alpha and transendothelial migration induced by high-dose (100 units/mL) tumor necrosis factor-alpha were significantly inhibited (p < .05, in each case). Hydroxyethyl Starch Derivatives 51-54 tumor necrosis factor Homo sapiens 107-134 18434912-10 2008 However, when HUVEC were cultured with 1.5% wt/vol HES, neutrophil capture induced by low-dose (1 unit/mL) tumor necrosis factor-alpha and transendothelial migration induced by high-dose (100 units/mL) tumor necrosis factor-alpha were significantly inhibited (p < .05, in each case). Hydroxyethyl Starch Derivatives 51-54 tumor necrosis factor Homo sapiens 202-229 18305082-11 2008 IL-6, IL-10, and sICAM-1 were significantly lower in the HES group than in the gelatin group on the first and second PODs. Hydroxyethyl Starch Derivatives 57-60 interleukin 6 Homo sapiens 0-4 18305082-11 2008 IL-6, IL-10, and sICAM-1 were significantly lower in the HES group than in the gelatin group on the first and second PODs. Hydroxyethyl Starch Derivatives 57-60 interleukin 10 Homo sapiens 6-11 19149679-1 2009 Both stereoisomer of hydroxyethylamine (HEA) and hydroxyethylsulfide (HES) transition-state isostere inhibitors of BACE-1 were synthesized. Hydroxyethyl Starch Derivatives 70-73 beta-secretase 1 Homo sapiens 115-121 19149679-3 2009 On the contrary, the anti epimer of the HES isostere resulted more active than the syn stereoisomer. Hydroxyethyl Starch Derivatives 40-43 synemin Homo sapiens 83-86 18067118-1 2008 CD133 (prominin-1) was the first in a class of novel pentaspan membrane proteins to be identified in both humans and mice, and was originally classified as a marker of primitive haematopoietic and neural stem cells. Hydroxyethyl Starch Derivatives 53-62 prominin 1 Homo sapiens 0-5 18067118-1 2008 CD133 (prominin-1) was the first in a class of novel pentaspan membrane proteins to be identified in both humans and mice, and was originally classified as a marker of primitive haematopoietic and neural stem cells. Hydroxyethyl Starch Derivatives 53-62 prominin 1 Homo sapiens 7-17 18399119-1 2007 OBJECTIVE: To explore the protective effects of hydroxyethyl starch (HES)(130/0.4) against ischemia reperfusion injury of kidney and its impact on the expression of intercellular adhesion molecule-1 (ICAM-1). Hydroxyethyl Starch Derivatives 69-72 intercellular adhesion molecule 1 Rattus norvegicus 165-198 18399119-1 2007 OBJECTIVE: To explore the protective effects of hydroxyethyl starch (HES)(130/0.4) against ischemia reperfusion injury of kidney and its impact on the expression of intercellular adhesion molecule-1 (ICAM-1). Hydroxyethyl Starch Derivatives 69-72 intercellular adhesion molecule 1 Rattus norvegicus 200-206 18399119-11 2007 CONCLUSION: Infusion of 10-20 ml/kg HES (130/0.4) significantly alleviates the ischemia-reperfusion injury, probably by reducing the ICAM-1 expression. Hydroxyethyl Starch Derivatives 36-39 intercellular adhesion molecule 1 Rattus norvegicus 133-139 17890952-9 2007 In conclusion, HES dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. Hydroxyethyl Starch Derivatives 15-18 serpin family F member 2 Homo sapiens 65-83 17923015-1 2007 OBJECTIVE: To observe the effect of hydroxyethyl starch (HES) 130/0.4 on S100B protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6%HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism. Hydroxyethyl Starch Derivatives 57-60 S100 calcium binding protein B Homo sapiens 73-78 17683357-13 2007 B-HES but not NB-HES increases the expression of activated platelet GP IIb/IIIa induced by ADP or TRAP. Hydroxyethyl Starch Derivatives 2-5 integrin subunit alpha 2b Homo sapiens 68-74 17683357-13 2007 B-HES but not NB-HES increases the expression of activated platelet GP IIb/IIIa induced by ADP or TRAP. Hydroxyethyl Starch Derivatives 2-5 TRAP Homo sapiens 98-102 17122237-10 2006 CONCLUSIONS: Patients with Type O blood may have increased coagulation compromise, and greater dilution of Factor VIII activity, vWF:ag, and vWF:RCof after acute normovolemic hemodilution with HES. Hydroxyethyl Starch Derivatives 193-196 von Willebrand factor Homo sapiens 141-144 17453968-7 2007 CD34(+) cell recovery was higher with Sepax (86+/-11.6%) than with HES (81.5+/-12.5%) and TB (82.0+/-17.7%) (P<0.008 and <0.0001, respectively) and results with HES and TB were not significantly different (P=0.7). Hydroxyethyl Starch Derivatives 67-70 CD34 molecule Homo sapiens 0-4 17453968-7 2007 CD34(+) cell recovery was higher with Sepax (86+/-11.6%) than with HES (81.5+/-12.5%) and TB (82.0+/-17.7%) (P<0.008 and <0.0001, respectively) and results with HES and TB were not significantly different (P=0.7). Hydroxyethyl Starch Derivatives 167-170 CD34 molecule Homo sapiens 0-4 17311869-5 2007 Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level. Hydroxyethyl Starch Derivatives 12-15 myeloperoxidase Rattus norvegicus 94-97 17311869-5 2007 Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level. Hydroxyethyl Starch Derivatives 12-15 tumor necrosis factor Rattus norvegicus 99-108 17311869-5 2007 Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level. Hydroxyethyl Starch Derivatives 12-15 interleukin 6 Rattus norvegicus 110-114 17311869-5 2007 Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level. Hydroxyethyl Starch Derivatives 12-15 interleukin 10 Rattus norvegicus 164-169 16987337-6 2006 RESULTS: Resuscitation with HES 130/0.4 significantly attenuated the CLP-induced increase in PCP, MPO activity, cytokine/chemokine levels, mRNA expression of P-selectin and NF-kappaB activation, all of which are involved in the recruitment of neutrophils. Hydroxyethyl Starch Derivatives 28-31 myeloperoxidase Rattus norvegicus 98-101 16987337-6 2006 RESULTS: Resuscitation with HES 130/0.4 significantly attenuated the CLP-induced increase in PCP, MPO activity, cytokine/chemokine levels, mRNA expression of P-selectin and NF-kappaB activation, all of which are involved in the recruitment of neutrophils. Hydroxyethyl Starch Derivatives 28-31 selectin P Rattus norvegicus 158-168 16790644-5 2006 HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 tumor necrosis factor Rattus norvegicus 61-88 16616763-7 2006 Without obvious influence on systemic macro-hemodynamics, HES 15 ml/kg and 30 ml/kg significantly reduced CLP-induced elevation of pulmonary capillary permeability, wet/dry weight ratio, and production of IL-6. Hydroxyethyl Starch Derivatives 58-61 interleukin 6 Rattus norvegicus 205-209 16616763-8 2006 Meanwhile, HES 15 ml/kg increased IL-10 level and HES 7.5, 15, and 30 ml/kg suppressed MPO activity, TNF-alpha level, and NF-kappaB activation. Hydroxyethyl Starch Derivatives 11-14 interleukin 10 Rattus norvegicus 34-39 16790644-5 2006 HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 interleukin 6 Rattus norvegicus 90-94 16790644-5 2006 HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 C-X-C motif chemokine ligand 1 Rattus norvegicus 96-141 16790652-8 2006 Plasma levels of interleukin-6 and soluble adhesion molecules were significantly (P < 0.05) higher in the HA- than in the HES-treated patients. Hydroxyethyl Starch Derivatives 125-128 interleukin 6 Homo sapiens 17-30 16464978-3 2006 In the present study we assessed the individual effects on blood coagulation of molar substitution and C2/C6 ratio of a high molecular weight HES. Hydroxyethyl Starch Derivatives 142-145 complement C6 Homo sapiens 103-108 16464978-13 2006 CONCLUSIONS: TEG analysis indicates that high molecular HES with a molar substitution of 0.42 and a C2/C6 ratio of 2.7 has the lowest effect on in vitro human blood coagulation. Hydroxyethyl Starch Derivatives 56-59 complement C2 Homo sapiens 100-118 16524504-6 2006 Compared to SHA group, bacterial count and TNF-alpha level were increased significantly in HES and RS groups, and they were higher at 1 hour and lower at 24 hours in HES group than those in RS group. Hydroxyethyl Starch Derivatives 91-94 tumor necrosis factor Rattus norvegicus 43-52 16524504-6 2006 Compared to SHA group, bacterial count and TNF-alpha level were increased significantly in HES and RS groups, and they were higher at 1 hour and lower at 24 hours in HES group than those in RS group. Hydroxyethyl Starch Derivatives 166-169 tumor necrosis factor Rattus norvegicus 43-52 16524504-7 2006 Compared to the SHA group, MPO activity increased at 1 hour in RS and HES groups, but no significant difference between the groups was found at 24 hours. Hydroxyethyl Starch Derivatives 70-73 myeloperoxidase Rattus norvegicus 27-30 16459183-1 2006 OBJECTIVE: The pentaspan molecule CD133 has been shown to be a marker of more primitive hematopoietic progenitors in mobilized peripheral blood (PB). Hydroxyethyl Starch Derivatives 15-24 prominin 1 Homo sapiens 34-39 16095459-8 2005 FI supplementation of HES 450, HES 220, HES 130 and albumin-diluted samples only partially restored alpha, A and G-values compared to undiluted samples. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 0-2 16146468-3 2005 The present study was undertaken to test whether HES (200/0.5) has some effects on tissue NF-kappaB activity and systemic TNF-alpha expression induced by lipopolysaccharide in order to define a possible mechanism of the beneficial effects of HES. Hydroxyethyl Starch Derivatives 49-52 tumor necrosis factor Rattus norvegicus 122-131 16146468-7 2005 RESULTS: 3.75 and 7.5 ml/kg HES suppressed LPS-induced NF-kappaB activation in the four tissues and decreased plasma TNF-alpha elevation. Hydroxyethyl Starch Derivatives 28-31 tumor necrosis factor Rattus norvegicus 117-126 16146468-10 2005 CONCLUSION: Lower doses of HES may inhibit tissue NF-kappaB activation and systemic TNF-alpha elevation after LPS challenge, which might be helpful during sepsis. Hydroxyethyl Starch Derivatives 27-30 tumor necrosis factor Rattus norvegicus 84-93 16793734-8 2006 RESULTS: The median PF1 percentage recovery of total nucleated cells (TNC) was comparable with both traditional methods (HES 79%, T&B 86%) and statistically reduced with both filtration procedures (filter A 58%, filter B 61%). Hydroxyethyl Starch Derivatives 121-124 PHD finger protein 12 Homo sapiens 20-23 16793734-9 2006 Mononuclear cell (MNC) PF1 recovery was highest statistically with the T&B method (91%) and reduced on using filter A (77%) and filter B (70%) and the HES method (72%). Hydroxyethyl Starch Derivatives 155-158 PHD finger protein 12 Homo sapiens 23-26 16247329-6 2005 The effect of HES on PMN surface expression of CD11b and L-selectin was measured by flow cytometry. Hydroxyethyl Starch Derivatives 14-17 integrin subunit alpha M Homo sapiens 47-52 16247329-6 2005 The effect of HES on PMN surface expression of CD11b and L-selectin was measured by flow cytometry. Hydroxyethyl Starch Derivatives 14-17 selectin L Homo sapiens 57-67 16247329-7 2005 PMN activation response to HES was measured using a shape-change assay in response to formyl-methionyl-leucyl-phenylalanine (f-MLP). Hydroxyethyl Starch Derivatives 27-30 cysteine and glycine rich protein 3 Homo sapiens 127-130 16247329-8 2005 The effect of HES on endothelial cell surface expression of E-selectin, P-selectin, vascular cell adhesion molecule-1(VCAM-1), and intracellular adhesion molecule-1 (ICAM-1) was evaluated by enzyme-linked immunoabsorbant assay. Hydroxyethyl Starch Derivatives 14-17 selectin E Homo sapiens 60-70 16247329-12 2005 In the absence of IL-1 stimulation, there was a small but statistically significant (P < 0.05) increase in ICAM-1 after exposure to HES. Hydroxyethyl Starch Derivatives 135-138 intercellular adhesion molecule 1 Homo sapiens 110-116 16104441-5 2005 HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs. Hydroxyethyl Starch Derivatives 0-3 tumor necrosis factor Rattus norvegicus 75-84 14980935-4 2004 HES was found to inhibit lung neutrophil accumulation, cytokine-induced neutrophil chemoattractant protein, and NF-kappaB activation in parallel and to inhibit CD11b expression in a dose-dependent manner. Hydroxyethyl Starch Derivatives 0-3 integrin subunit alpha M Rattus norvegicus 160-165 15836676-7 2005 HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 tumor necrosis factor Rattus norvegicus 58-67 15836676-7 2005 HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 interleukin 1 beta Rattus norvegicus 69-77 15836676-7 2005 HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 interleukin 6 Rattus norvegicus 79-83 15748433-6 2005 The ABO-incompatible patients received grafts depleted erythrocytes by hydroxyethyl starch (HES) sedimentation. Hydroxyethyl Starch Derivatives 92-95 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 4-7 16104441-5 2005 HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs. Hydroxyethyl Starch Derivatives 0-3 interleukin 1 beta Rattus norvegicus 86-94 16104441-5 2005 HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs. Hydroxyethyl Starch Derivatives 0-3 interleukin 6 Rattus norvegicus 96-100 16104441-7 2005 The results suggest that in sepsis, HES may down-regulate intestinal pro-inflammatory cytokine production via suppression of NF-kappaB and AP-1 activation. Hydroxyethyl Starch Derivatives 36-39 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-143 15934983-6 2005 Recoveries of CD34+ and RBC depletion were significantly better for the HES group. Hydroxyethyl Starch Derivatives 72-75 CD34 molecule Homo sapiens 14-18 15608046-13 2005 CONCLUSION: Coagulopathy induced by haemodilution with either HES 200/0.5, HES 130/0.4, and dextran 70 may be improved by fibrinogen supplementation. Hydroxyethyl Starch Derivatives 62-65 fibrinogen beta chain Homo sapiens 122-132 15608046-13 2005 CONCLUSION: Coagulopathy induced by haemodilution with either HES 200/0.5, HES 130/0.4, and dextran 70 may be improved by fibrinogen supplementation. Hydroxyethyl Starch Derivatives 75-78 fibrinogen beta chain Homo sapiens 122-132 15698484-11 2005 Dobutamine in LRS+HES resuscitation+dobutamine treatment group could also greatly decrease lactate and Pt-aCO2 gap, significantly improve pHi compared with LRS resuscitation+dobutamine treatment group (all P<0.05). Hydroxyethyl Starch Derivatives 18-21 aconitate hydratase, mitochondrial Oryctolagus cuniculus 106-110 15698484-11 2005 Dobutamine in LRS+HES resuscitation+dobutamine treatment group could also greatly decrease lactate and Pt-aCO2 gap, significantly improve pHi compared with LRS resuscitation+dobutamine treatment group (all P<0.05). Hydroxyethyl Starch Derivatives 18-21 glucose-6-phosphate isomerase Oryctolagus cuniculus 138-141 15271734-7 2004 Hemodilution with pentastarch caused a transient increase in MAP, no change in P(Br)o(2), and a sustained increase in rCBF (P < 0.05), whereas the hemoglobin concentration and oxygen content were significantly reduced. Hydroxyethyl Starch Derivatives 18-29 CCAAT/enhancer binding protein zeta Rattus norvegicus 118-122 15298802-11 2004 Low dose of HES could greatly decrease lactate and Pt-aCO(2) gap, significantly improve pHi compared with other three groups (all P<0.05), but high dose of HES did not do so, and oral and nasal bleeding even death of some animals were seen. Hydroxyethyl Starch Derivatives 12-15 glucose-6-phosphate isomerase Oryctolagus cuniculus 88-91 14980935-4 2004 HES was found to inhibit lung neutrophil accumulation, cytokine-induced neutrophil chemoattractant protein, and NF-kappaB activation in parallel and to inhibit CD11b expression in a dose-dependent manner. Hydroxyethyl Starch Derivatives 0-3 nuclear factor kappa B subunit 1 Homo sapiens 112-121 14980935-5 2004 These findings demonstrate that HES has beneficial effects on capillary leak in acute lung injury and that the mechanisms underlying this action involve an antiinflammatory effect of HES, including inhibition of NF-kappaB activation. Hydroxyethyl Starch Derivatives 32-35 nuclear factor kappa B subunit 1 Homo sapiens 212-221 14980935-5 2004 These findings demonstrate that HES has beneficial effects on capillary leak in acute lung injury and that the mechanisms underlying this action involve an antiinflammatory effect of HES, including inhibition of NF-kappaB activation. Hydroxyethyl Starch Derivatives 183-186 nuclear factor kappa B subunit 1 Homo sapiens 212-221 14675410-2 2004 However, the recently described pentaspan molecule CD133 appears to be a marker of more primitive haematopoietic progenitors. Hydroxyethyl Starch Derivatives 32-41 prominin 1 Homo sapiens 51-56 12812678-5 2003 RESULTS: At the end of surgery, the Ps-aCO(2) gap was 8.7 mm Hg +/- 1.6 mm Hg in the HES group, significantly lower than that in the LRS group (18.74 mm Hg +/- 4.4 mm Hg, P < 0.01), while the pHi in the HES group was 7.30 +/- 0.05, significantly higher than that in the LRS group (7.21 +/- 0.07, P < 0.01). Hydroxyethyl Starch Derivatives 85-88 glucose-6-phosphate isomerase Homo sapiens 195-198 12538178-9 2003 The changes in factor VIII, activated partial thromboplastin time, and TEG measurements indicate that HES and DEX may attenuate the hypercoagulability related to surgery. Hydroxyethyl Starch Derivatives 102-105 cytochrome c oxidase subunit 8A Homo sapiens 22-26 14584760-2 2003 The present study tested the hypothesis that HES has effects on nuclear factor kappa B (NF-kappaB) activation and the expression of inflammatory mediators induced by lipopolysaccharide. Hydroxyethyl Starch Derivatives 45-48 nuclear factor kappa B subunit 1 Homo sapiens 88-97 14584760-6 2003 Treatment of rats with HES (3.75 and 7.5 ml/kg) prevented LPS-induced NF-kappaB activation, and inhibited, in a dose-related manner, LPS-induced TNF-alpha and CINC expression. Hydroxyethyl Starch Derivatives 23-26 nuclear factor kappa B subunit 1 Homo sapiens 70-79 14584760-6 2003 Treatment of rats with HES (3.75 and 7.5 ml/kg) prevented LPS-induced NF-kappaB activation, and inhibited, in a dose-related manner, LPS-induced TNF-alpha and CINC expression. Hydroxyethyl Starch Derivatives 23-26 tumor necrosis factor Rattus norvegicus 145-154 14584760-7 2003 The 4 graded doses of HES decreased CD11b expression in a dose-dependent manner. Hydroxyethyl Starch Derivatives 22-25 integrin subunit alpha M Rattus norvegicus 36-41 12890370-5 2003 RESULTS: At the end of surgery,the Ps-a CO(2) gap in the HES group (8.7 +/- 1.6 mmHg) was significantly lower than that of the LRS group (18.74 +/- 4.4 mmHg, P < 0.01), while the pHi (7.30 +/- 0.05 mmHg) in the HES group was significantly higher than that of the LRS group (7.21 +/- 0.07 mmHg, P < 0.01). Hydroxyethyl Starch Derivatives 57-60 glucose-6-phosphate isomerase Homo sapiens 182-185 11731236-0 2001 Early patterning of the prospective midbrain-hindbrain boundary by the HES-related gene XHR1 in Xenopus embryos. Hydroxyethyl Starch Derivatives 71-74 hairy and enhancer of split 7, gene 1 L homeolog Xenopus laevis 88-92 12351257-7 2002 The decrease in fibronectin concentrations was significantly smaller with GEL as compared with HES, whereas a weak trend toward a larger decrease in fibrinogen concentrations was observed with both colloids. Hydroxyethyl Starch Derivatives 95-98 fibronectin 1 Homo sapiens 16-27 10416917-9 1999 At a low cTNI concentration (0.32 microg/l), interference was observed with SS and HES at 40 and 80% dilution and with P and Alb at 80%. Hydroxyethyl Starch Derivatives 83-86 troponin I3, cardiac type Homo sapiens 9-13 11463545-7 2001 During CPB, COP was reduced by 20% in the HES-group (18.9 +/- 3.7 vs. 23.7 +/- 2.2 mmHg, P < 0.05) while it was reduced by more than 50% of the pre-CPB value (9.8 +/- 2.0 vs. 21.4 +/- 2.1 mmHg, P < 0.05) in the crystalloid group (P < 0.05 HES- vs. crystalloid group). Hydroxyethyl Starch Derivatives 42-45 caspase recruitment domain family member 16 Homo sapiens 12-15 10874614-7 1999 RESULTS: Postoperative prothrombin time (PT) was slightly higher with pentastarch (P: 14.9 +/- 1.5 seconds, A: 14.2 +/- 1.3 seconds, p = 0.003). Hydroxyethyl Starch Derivatives 70-81 coagulation factor II, thrombin Homo sapiens 23-34 11810130-0 2001 Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects. Hydroxyethyl Starch Derivatives 111-130 ribosome binding protein 1 Homo sapiens 132-135 11375811-6 2001 The decrease in VIII/vWF complex was proportional to the volume of infused HES (20 and 30 mL/kg) and was more pronounced in patients of the O blood group. Hydroxyethyl Starch Derivatives 75-78 cytochrome c oxidase subunit 8A Homo sapiens 16-20 11375811-6 2001 The decrease in VIII/vWF complex was proportional to the volume of infused HES (20 and 30 mL/kg) and was more pronounced in patients of the O blood group. Hydroxyethyl Starch Derivatives 75-78 von Willebrand factor Homo sapiens 21-24 11375812-8 2001 This study shows that HES 450/0.7--0.8, HES 200/0.6--0.66, and HES 70/0.5--0.55 inhibit platelet function by reducing the availability of the functional receptor for fibrinogen on the platelet surface. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 166-176 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 0-27 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 29-33 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 34-37 10714833-7 2000 Significant correlation between changes in deltaDown and EDA was noted following HES (r=0.78, P<0.05). Hydroxyethyl Starch Derivatives 81-84 ectodysplasin A Sus scrofa 57-60 10608543-3 1999 The aim of this study was to compare the effects of posttrauma resuscitation with hydroxyethyl starch (HES) (molecular mass, 250 kDa) or gelatine (molecular mass, 30 kDa), the hypothesis being that HES would reduce capillary leak. Hydroxyethyl Starch Derivatives 82-101 ribosome binding protein 1 Homo sapiens 103-106 10608543-3 1999 The aim of this study was to compare the effects of posttrauma resuscitation with hydroxyethyl starch (HES) (molecular mass, 250 kDa) or gelatine (molecular mass, 30 kDa), the hypothesis being that HES would reduce capillary leak. Hydroxyethyl Starch Derivatives 82-101 ribosome binding protein 1 Homo sapiens 198-201 10416917-11 1999 The highest interference was observed with HES, the lowest with P. When the dilution was at 80% for increasing concentrations of cTNI, the higher the initial cTNI was the higher the interference appeared, mostly with SS and HES. Hydroxyethyl Starch Derivatives 43-46 troponin I3, cardiac type Homo sapiens 129-133 10416917-11 1999 The highest interference was observed with HES, the lowest with P. When the dilution was at 80% for increasing concentrations of cTNI, the higher the initial cTNI was the higher the interference appeared, mostly with SS and HES. Hydroxyethyl Starch Derivatives 43-46 troponin I3, cardiac type Homo sapiens 158-162 10416917-11 1999 The highest interference was observed with HES, the lowest with P. When the dilution was at 80% for increasing concentrations of cTNI, the higher the initial cTNI was the higher the interference appeared, mostly with SS and HES. Hydroxyethyl Starch Derivatives 224-227 troponin I3, cardiac type Homo sapiens 129-133 10416917-11 1999 The highest interference was observed with HES, the lowest with P. When the dilution was at 80% for increasing concentrations of cTNI, the higher the initial cTNI was the higher the interference appeared, mostly with SS and HES. Hydroxyethyl Starch Derivatives 224-227 troponin I3, cardiac type Homo sapiens 158-162 10416917-12 1999 CONCLUSIONS: SS, P, Alb, and HES interfere in this cTNI immunoassay. Hydroxyethyl Starch Derivatives 29-32 troponin I3, cardiac type Homo sapiens 51-55 10416917-13 1999 This interference is higher with SS and HES and is higher when the percentage of hemodilution or real cTNI concentration increases. Hydroxyethyl Starch Derivatives 40-43 troponin I3, cardiac type Homo sapiens 102-106 9699031-8 1998 The single clotting factors FI, FII, FV, FVII, FVIII, FX, and FXII behaved approximately in the same way: their activities directly after infusion, but also 6 h later, were lowered in proportion to the amount of HES infused. Hydroxyethyl Starch Derivatives 212-215 coagulation factor VIII Homo sapiens 47-52 10229159-6 1999 A high degree of substitution and a high C2/C6 ratio lead to a slow metabolization of HES, resulting in a large in vivo MW. Hydroxyethyl Starch Derivatives 86-89 complement C6 Homo sapiens 41-46 9847657-11 1998 Only in studies of hemodilution lasting 10 days with 6% HES 200/0.62 has VIII/von Willebrand complex been shown to decrease. Hydroxyethyl Starch Derivatives 56-59 cytochrome c oxidase subunit 8A Homo sapiens 73-77 8899187-4 1996 After cooling at 1 degree C/min in solutions containing 4% HES and various concentrations of DMSO there was a dramatic fall in CD34+ recovery from 85.4% (s.d. Hydroxyethyl Starch Derivatives 59-62 CD34 molecule Homo sapiens 127-131 9215020-2 1997 Haemodilution with HES, GEL and ALB significantly (P < 0.05) compromised coagulation time (k), angle alpha and maximal amplitude (MA), with HES having the most negative effect at 30% and 60% haemodilution (P < 0.05). Hydroxyethyl Starch Derivatives 143-146 albumin Homo sapiens 32-35 9640378-6 1998 We found a 50% decreased activity of the acid GAA, which is consistent with a heterozygous state of glycogenosis type II (Pompe"s disease) and potentially of pathogenetic relevance for the intralysosomal accumulation of HES. Hydroxyethyl Starch Derivatives 220-223 alpha glucosidase Homo sapiens 46-49 9640378-8 1998 This observation could point to a role for GAA in the elimination of tissue-stored HES. Hydroxyethyl Starch Derivatives 83-86 alpha glucosidase Homo sapiens 43-46 9640378-9 1998 Patients with decreased activities of GAA may be at risk of unusual adverse effects following extraordinary and prolonged tissue storage of HES, especially if it is infused in large quantities. Hydroxyethyl Starch Derivatives 140-143 alpha glucosidase Homo sapiens 38-41 9140565-9 1997 Prothrombin time, APTT, and fibrinogen concentrations decreased after infusions and vWf:Ag and FVIII:C activities were decreased in dose-dependent manner in HES-treated ponies. Hydroxyethyl Starch Derivatives 157-160 von Willebrand factor Homo sapiens 84-87 8060252-6 1994 NE and ANG-II induced an increase in PP in all groups, but NE-induced and ANG-II-induced responses in the PHP-perfused and SFH-perfused groups were significantly larger than those in the HES-perfused group. Hydroxyethyl Starch Derivatives 187-190 angiotensinogen Rattus norvegicus 74-80 8825225-1 1995 We studied the haemostatic and volume effects of synthetic plasma substitutes and Ringer"s solution in 48 surgical patients and found that the measured fibrinogen concentrations of patients receiving either dextran or hydroxyethyl starch (HES) were significantly higher than those predicted by the dilutional effects. Hydroxyethyl Starch Derivatives 239-242 fibrinogen beta chain Homo sapiens 152-162 8825225-9 1995 We conclude that the results of indirect fibrinogen assays should be interpreted cautiously, when HES or dextran is used for volume replacement. Hydroxyethyl Starch Derivatives 98-101 fibrinogen beta chain Homo sapiens 41-51 8777364-8 1996 10% HES 200/0.62 caused a Fn decrease from 26.6 +/- 9.2 to 10.0 +/- 2.2 mg/dl (-62.2%), 6% HES reduced Fn from 25.5 +/- 9.9 to 15.0 +/- 3.2 mg/dl (-41.1%). Hydroxyethyl Starch Derivatives 4-7 fibronectin 1 Homo sapiens 26-28 8777364-8 1996 10% HES 200/0.62 caused a Fn decrease from 26.6 +/- 9.2 to 10.0 +/- 2.2 mg/dl (-62.2%), 6% HES reduced Fn from 25.5 +/- 9.9 to 15.0 +/- 3.2 mg/dl (-41.1%). Hydroxyethyl Starch Derivatives 4-7 fibronectin 1 Homo sapiens 103-105 8777364-8 1996 10% HES 200/0.62 caused a Fn decrease from 26.6 +/- 9.2 to 10.0 +/- 2.2 mg/dl (-62.2%), 6% HES reduced Fn from 25.5 +/- 9.9 to 15.0 +/- 3.2 mg/dl (-41.1%). Hydroxyethyl Starch Derivatives 91-94 fibronectin 1 Homo sapiens 103-105 35178114-8 2022 Results: HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-alpha. Hydroxyethyl Starch Derivatives 9-12 mitogen activated protein kinase 3 Rattus norvegicus 124-130 1377457-7 1992 The acute phase reaction of factor VIII coagulant and von Willebrand factor, which plays a role in postoperative hypercoagulability, was attenuated by the use of HES. Hydroxyethyl Starch Derivatives 162-165 von Willebrand factor Homo sapiens 54-75 34803697-7 2021 Additionally, we found that the efficacy of HES-CUR NPs against HepG2 cells might be related to the enhanced degree of mitochondrial damage (decrease of the mitochondrial membrane potential and ATP) and autophagy (increased levels of Beclin-1 and LC3-II proteins). Hydroxyethyl Starch Derivatives 44-47 beclin 1 Homo sapiens 234-242 1713876-4 1991 The manipulation with HES permitted to concentrate marrow stem cells in a small volume with removal of unwanted granulocytes, red blood cells and the donor isohemagglutinins in the major ABH incompatibility. Hydroxyethyl Starch Derivatives 22-25 alkB homolog 1, histone H2A dioxygenase Homo sapiens 187-190 35178114-8 2022 Results: HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-alpha. Hydroxyethyl Starch Derivatives 9-12 interleukin 6 Rattus norvegicus 169-173 35178114-8 2022 Results: HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-alpha. Hydroxyethyl Starch Derivatives 9-12 tumor necrosis factor Rattus norvegicus 178-187 35178114-9 2022 However, inhibition of ERK signaling pathway reversed the effect of HES on the immune improvement and the 24-h survival rate of the traumatic shock rats (P < 0.05). Hydroxyethyl Starch Derivatives 68-71 Eph receptor B1 Rattus norvegicus 23-26 35178114-10 2022 Conclusion: HES could exert the anti-inflammatory effects on lymphocytes by mediating the phosphorylation of proteins of the ERK signaling pathway. Hydroxyethyl Starch Derivatives 12-15 Eph receptor B1 Rattus norvegicus 125-128 2411030-5 1985 Following infusion of HES and albumin, plasma fibrinogen and antithrombin-III levels fell slightly due to plasma volume expansion and hemodilution. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 46-56 2431085-3 1986 For purified fibrin gels clotted with thrombin the mass/length ratio increased in a linear fashion from 2.6 to 6.1 X 10(12) daltons/cm as HES increased from 0 to 15 mg/ml. Hydroxyethyl Starch Derivatives 138-141 coagulation factor II, thrombin Homo sapiens 38-46 2431085-7 1986 The fiber mass/length ratio for plasma gels clotted with thrombin increased from 0.3 to 1.7 X 10(12) daltons/cm as HES increased from 0 to 20 mg/ml. Hydroxyethyl Starch Derivatives 115-118 coagulation factor II, thrombin Homo sapiens 57-65 2413591-3 1985 When HES was used in only the first three passes, the subsequent three passes, done with acid-citrate-dextrose, Formula-A (ACD-A, Fenwal Laboratories, Deerfield, IL), reduced the yield to 0.14 +/- 0.06 (mean +/- SD) X 10(10) per LBP. Hydroxyethyl Starch Derivatives 5-8 lipopolysaccharide binding protein Homo sapiens 229-232 2413591-5 1985 When the HES dose was reduced to one-half strength on the second consecutive day of leukacytapheresis, the granulocyte yields were reduced from 0.57 +/- 0.15 X 10(10) per LBP to 0.42 +/- 0.07 X 10(10) per LBP. Hydroxyethyl Starch Derivatives 9-12 lipopolysaccharide binding protein Homo sapiens 171-174 2413591-5 1985 When the HES dose was reduced to one-half strength on the second consecutive day of leukacytapheresis, the granulocyte yields were reduced from 0.57 +/- 0.15 X 10(10) per LBP to 0.42 +/- 0.07 X 10(10) per LBP. Hydroxyethyl Starch Derivatives 9-12 lipopolysaccharide binding protein Homo sapiens 205-208 2413591-6 1985 Use of one-half strength HES on first-time donors gave yields of only 0.35 +/- 0.39 X 10(10) per LBP. Hydroxyethyl Starch Derivatives 25-28 lipopolysaccharide binding protein Homo sapiens 97-100 2413591-7 1985 Infusion of the entire 500-ml dose of HES one-half hour prior to the procedure produced low yields of 0.20 +/- 0.12 X 10(10) per LBP, indicating that HES must be present during the centrifugation and separation procedure in order to enhance yields. Hydroxyethyl Starch Derivatives 38-41 lipopolysaccharide binding protein Homo sapiens 129-132 2411030-5 1985 Following infusion of HES and albumin, plasma fibrinogen and antithrombin-III levels fell slightly due to plasma volume expansion and hemodilution. Hydroxyethyl Starch Derivatives 22-25 serpin family C member 1 Homo sapiens 61-77 2408362-3 1985 Results of in vivo studies were as follows: following infusion of 1 liter of 6 percent HES into healthy subjects, fibrinogen and antithrombin-III concentrations fell slightly due to plasma volume expansion and consequent dilution. Hydroxyethyl Starch Derivatives 87-90 fibrinogen beta chain Homo sapiens 114-124 2408362-3 1985 Results of in vivo studies were as follows: following infusion of 1 liter of 6 percent HES into healthy subjects, fibrinogen and antithrombin-III concentrations fell slightly due to plasma volume expansion and consequent dilution. Hydroxyethyl Starch Derivatives 87-90 serpin family C member 1 Homo sapiens 129-145 2408362-8 1985 Shortened thrombin, reptilase, and urokinase-activated clot lysis times were reproduced in vitro by mixing HES, but not albumin or NaCl, with normal plasma. Hydroxyethyl Starch Derivatives 107-110 coagulation factor II, thrombin Homo sapiens 10-18 32641360-5 2020 A deidentified version of SLaM"s EHR was available via the Clinical Record Interactive Search system linked to HES-ONS mortality records. Hydroxyethyl Starch Derivatives 111-114 signaling lymphocytic activation molecule family member 1 Homo sapiens 26-30 2418087-3 1985 There was a slight shortening in the thrombin time and a smaller increase in post-operative FVIII RAg and FVIII RCof levels in the HES group. Hydroxyethyl Starch Derivatives 131-134 coagulation factor VIII Homo sapiens 92-97 2418087-3 1985 There was a slight shortening in the thrombin time and a smaller increase in post-operative FVIII RAg and FVIII RCof levels in the HES group. Hydroxyethyl Starch Derivatives 131-134 coagulation factor VIII Homo sapiens 106-111 6195981-4 1983 Both groups exhibited below normal antithrombin III and plasminogen levels, with significantly lower antithrombin III levels noted in the HES group postoperatively (41.9 +/- 11.8% versus 56.6 +/- 9.9%; p = 0.006). Hydroxyethyl Starch Derivatives 138-141 serpin family C member 1 Homo sapiens 101-117 6203575-2 1983 The present investigation has shown that the dynamic viscosity of HES (232,000 and 565,000 daltons) solutions rises in a nonlinear fashion with increasing HES concentration, and for a given concentration of HES exhibits Newtonian behavior at shear rates between 0.15 to 124 sec-1. Hydroxyethyl Starch Derivatives 66-69 secretory blood group 1, pseudogene Homo sapiens 274-279 6203575-5 1983 At high (greater than 36 sec-1) shear rates the relative viscosity (eta/eta O) of RBC suspensions slowly decreases with increasing HES concentration. Hydroxyethyl Starch Derivatives 131-134 endothelin receptor type A Homo sapiens 68-71 6203575-5 1983 At high (greater than 36 sec-1) shear rates the relative viscosity (eta/eta O) of RBC suspensions slowly decreases with increasing HES concentration. Hydroxyethyl Starch Derivatives 131-134 endothelin receptor type A Homo sapiens 72-75 6203575-6 1983 At low shear rates eta/eta O increases and then decreases with increasing HES concentration. Hydroxyethyl Starch Derivatives 74-77 endothelin receptor type A Homo sapiens 19-22 6203575-6 1983 At low shear rates eta/eta O increases and then decreases with increasing HES concentration. Hydroxyethyl Starch Derivatives 74-77 endothelin receptor type A Homo sapiens 23-26 6197944-5 1984 Coagulation variables were similar, but prothrombin and partial thromboplastin times were higher 12 hours postoperatively and fibrinogen level was lower 7 days postoperatively in the patients receiving HES. Hydroxyethyl Starch Derivatives 202-205 fibrinogen beta chain Homo sapiens 126-136 84346-6 1978 N-acetylated metabolites of PAH were released at a 5 times higher rate by kidneys perfused with FC 43 than by HES-perfused organs. Hydroxyethyl Starch Derivatives 110-113 phenylalanine hydroxylase Rattus norvegicus 28-31 33852594-8 2021 Monolayers of single cultures or co-cultures of hCMEC/D3 cells and astrocytes on fibronectin-coated Rinzl coverslips retained membrane integrities and metabolic function, after freezing in 5% DMSO, 6% HES, and 2% chondroitin sulfate, that were comparable to those of unfrozen controls even after overnight incubation. Hydroxyethyl Starch Derivatives 201-204 fibronectin 1 Homo sapiens 81-92 33360692-6 2021 RESULTS: Using AR and HES alone had no significant effect on the coagulation function of THS rats, but the two in combination reduced the increases of thrombin time, prothrombin time, activated part thrombin time, international normalized ratio, fibrin degradation products, D-dimer and the decreases of platelet count and fibrinogen concentration induced by THS. Hydroxyethyl Starch Derivatives 22-25 coagulation factor II Rattus norvegicus 151-159 33360692-7 2021 The CT and CFT were significantly reduced, whereas alpha and MCF were increased in the THS rats in AR + HES group. Hydroxyethyl Starch Derivatives 104-107 ferredoxin reductase Rattus norvegicus 99-101 30275683-14 2018 In addition, HES significantly increased the activity of caspases 3 and 8 in the UUO-HES group, in comparison with the HES group. Hydroxyethyl Starch Derivatives 13-16 caspase 3 Rattus norvegicus 57-73 32478070-5 2020 Our IRSH results obtained on control (WT, n = 3) and Lum -/- (n = 3) mice showed that different histological structures were identified by using K-means clustering and validated by hematoxylin eosin saffron (HES) staining. Hydroxyethyl Starch Derivatives 208-211 lumican Mus musculus 53-56 32457611-9 2020 HES (130/0.4) significantly improved the vascular barrier function, recovered the thickness and the expression of components of the endothelial glycocalyx by down-regulating the expression of heparinase, hyaluronidase, and neuraminidase, and meanwhile increased the expression of intercellular junction proteins ZO-1, occludin, and VE-cadherin. Hydroxyethyl Starch Derivatives 0-3 tight junction protein 1 Rattus norvegicus 312-316 32457611-9 2020 HES (130/0.4) significantly improved the vascular barrier function, recovered the thickness and the expression of components of the endothelial glycocalyx by down-regulating the expression of heparinase, hyaluronidase, and neuraminidase, and meanwhile increased the expression of intercellular junction proteins ZO-1, occludin, and VE-cadherin. Hydroxyethyl Starch Derivatives 0-3 occludin Rattus norvegicus 318-326 32457611-9 2020 HES (130/0.4) significantly improved the vascular barrier function, recovered the thickness and the expression of components of the endothelial glycocalyx by down-regulating the expression of heparinase, hyaluronidase, and neuraminidase, and meanwhile increased the expression of intercellular junction proteins ZO-1, occludin, and VE-cadherin. Hydroxyethyl Starch Derivatives 0-3 cadherin 5 Rattus norvegicus 332-343 31614325-8 2020 The hematocrit (Hct)-corrected syndecan-1 level was significantly increased after 15 mL/kg HES fluid administration (19.78 +- 3.83 ng/mL) compared with the Hct-correct baseline syndecan-1 level (15.67 +- 2.35 ng/mL) in patients in the glioma brain group. Hydroxyethyl Starch Derivatives 91-94 syndecan 1 Homo sapiens 31-41 31614325-9 2020 Similarly, for patients in the normal brain group, Hct-corrected syndecan-1 level was significantly increased after HES loading (34.71 +- 12.83 ng/mL) compared with the baseline syndecan-1 level (26.07 +- 12.52 ng/mL). Hydroxyethyl Starch Derivatives 116-119 syndecan 1 Homo sapiens 65-75 29509042-5 2019 The expression level of TNF-alpha in the LR group was significantly lower than that in the HES group, especially during the first 12 hr post-fluid infusion. Hydroxyethyl Starch Derivatives 91-94 tumor necrosis factor Rattus norvegicus 24-33 30934131-7 2019 HES resulted in lower CD11b expression and higher CD62L expression compared to MFG and the controls, whereas the differences for CD66b did not reach statistical significance. Hydroxyethyl Starch Derivatives 0-3 integrin subunit alpha M Homo sapiens 22-27 30934131-7 2019 HES resulted in lower CD11b expression and higher CD62L expression compared to MFG and the controls, whereas the differences for CD66b did not reach statistical significance. Hydroxyethyl Starch Derivatives 0-3 selectin L Homo sapiens 50-55 31820457-5 2019 RESULTS: NGAL recovery from urine specimens containing up to 75% HES and up to 62.5% GEL was within acceptable limits (80%-120%). Hydroxyethyl Starch Derivatives 65-68 lipocalin 2 Canis lupus familiaris 9-13 31059770-9 2019 Both, HES and HES/albumin increased the permeability of HUVEC monolayers (P<0.001), while LDH release, caspase-3/7 activity, akt/erk phosphorylation and claudin-3 expression were not affected. Hydroxyethyl Starch Derivatives 6-9 claudin 3 Homo sapiens 153-162 31059770-9 2019 Both, HES and HES/albumin increased the permeability of HUVEC monolayers (P<0.001), while LDH release, caspase-3/7 activity, akt/erk phosphorylation and claudin-3 expression were not affected. Hydroxyethyl Starch Derivatives 14-17 claudin 3 Homo sapiens 153-162 31401048-10 2019 Dogs given HES showed divergence between median TPPr and TPPb after T20, with a peak bias at T20 of 1.62 g dL-1 (LOA 1.29-1.95). Hydroxyethyl Starch Derivatives 11-14 l(1)L1 Drosophila melanogaster 107-111 30769810-9 2019 HES treatment impaired the chemotaxis only towards fMLP, event mainly ascribed to the inhibition of CD-11b (Mac-1 integrin) activity. Hydroxyethyl Starch Derivatives 0-3 integrin subunit alpha M Homo sapiens 100-106 30769810-9 2019 HES treatment impaired the chemotaxis only towards fMLP, event mainly ascribed to the inhibition of CD-11b (Mac-1 integrin) activity. Hydroxyethyl Starch Derivatives 0-3 integrin subunit alpha M Homo sapiens 108-113 30692882-7 2019 Patients with urinary NGAL >50 ng/mL were insignificantly higher for group RL versus group HES (6/19 vs. 4/19) (P = 0.461), as were those with incidence of AKI as per creatinine values (5/19 vs. 4/19) (P = 1.000). Hydroxyethyl Starch Derivatives 94-97 lipocalin 2 Homo sapiens 22-26 30275683-14 2018 In addition, HES significantly increased the activity of caspases 3 and 8 in the UUO-HES group, in comparison with the HES group. Hydroxyethyl Starch Derivatives 85-88 caspase 3 Rattus norvegicus 57-73 30275683-14 2018 In addition, HES significantly increased the activity of caspases 3 and 8 in the UUO-HES group, in comparison with the HES group. Hydroxyethyl Starch Derivatives 85-88 caspase 3 Rattus norvegicus 57-73 28481865-12 2017 4) HES significantly decreased antithrombin activity (AT: A) of the anticoagulant system with increasing HR vs. baseline and RL. Hydroxyethyl Starch Derivatives 3-6 serpin family C member 1 Homo sapiens 31-43 28724904-8 2017 The apoptosis rate in HS was significantly lower than that in the NS and HES groups, suggesting HS treatment during resuscitation could effectively suppress neuronal cell apoptosis in hippocampal CA1 post-ROSC and improve neuronal function. Hydroxyethyl Starch Derivatives 73-76 carbonic anhydrase 1 Rattus norvegicus 196-199 27701459-1 2016 The pentaspan membrane glycoprotein prominin-1 (CD133) is widely used in medicine as a cell surface marker of stem and cancer stem cells. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Canis lupus familiaris 36-46 27882140-8 2016 Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-alpha in the HES group compared with the control group. Hydroxyethyl Starch Derivatives 179-182 interleukin 1 alpha Homo sapiens 153-157 27882140-8 2016 Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-alpha in the HES group compared with the control group. Hydroxyethyl Starch Derivatives 179-182 tumor necrosis factor Homo sapiens 162-171 27882140-11 2016 Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient"s immune status as well as renal function during the early phase of SAP. Hydroxyethyl Starch Derivatives 6-9 interleukin 1 alpha Homo sapiens 51-55 27882140-11 2016 Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient"s immune status as well as renal function during the early phase of SAP. Hydroxyethyl Starch Derivatives 6-9 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 28222674-3 2017 This multi-center, randomized, double-blinded, placebo-controlled study aimed to investigate whether 6% HES 130/0.4 administration caused postoperative AKI, which can be revealed by urinary and plasma NGAL and IL-18 estimations in elderly patients with normal renal function undergoing hip arthroplasty under spinal anesthesia. Hydroxyethyl Starch Derivatives 104-107 lipocalin 2 Homo sapiens 201-205 28222674-3 2017 This multi-center, randomized, double-blinded, placebo-controlled study aimed to investigate whether 6% HES 130/0.4 administration caused postoperative AKI, which can be revealed by urinary and plasma NGAL and IL-18 estimations in elderly patients with normal renal function undergoing hip arthroplasty under spinal anesthesia. Hydroxyethyl Starch Derivatives 104-107 interleukin 18 Homo sapiens 210-215 27701459-1 2016 The pentaspan membrane glycoprotein prominin-1 (CD133) is widely used in medicine as a cell surface marker of stem and cancer stem cells. Hydroxyethyl Starch Derivatives 4-13 prominin 1 Homo sapiens 48-53 27502495-10 2016 Rates of HEs with DPP-4 inhibitors were not significantly different versus placebo in any study. Hydroxyethyl Starch Derivatives 9-12 dipeptidyl peptidase 4 Homo sapiens 18-23 26893443-1 2016 BACKGROUND: Intravenous fluids with synthetic colloids such as hydroxyethyl starch (HES) are known to interfere with plasma fibrinogen concentration measurements. Hydroxyethyl Starch Derivatives 84-87 fibrinogen beta chain Homo sapiens 124-134 26893443-11 2016 CONCLUSION: Despite providing different fibrinogen concentration values at baseline, the relative decrease in fibrinogen concentration after HES infusion was comparable among the 3 tests. Hydroxyethyl Starch Derivatives 141-144 fibrinogen beta chain Homo sapiens 110-120 26893443-12 2016 In contrast, fibrin-based clot quality was more affected than fibrinogen concentration tests by HES infusion. Hydroxyethyl Starch Derivatives 96-99 fibrinogen beta chain Homo sapiens 62-72 27504382-3 2016 Albumin & HES had better fluid balance which affect outcome in paediatric cardiac surgery significantly. Hydroxyethyl Starch Derivatives 14-17 albumin Homo sapiens 0-7 27576693-3 2016 We aimed to evaluate the effect of HES on perioperative cystatin C (cystC)-derived estimated glomerular filtration rates (eGFRcystC) in patients undergoing open and robot-assisted radical prostatectomy. Hydroxyethyl Starch Derivatives 35-38 cystatin C Homo sapiens 56-66 26603798-4 2015 The thromboelastographic functional fibrinogen assay showed that the fibrinogen component of clot strength was significantly impaired with haemodilution with HES 130/0.4 compared with haemodilution with NS (whole blood [14.4 +- 4.6 mm] versus 40% HES dilution [3.7 +- 1.9], [P=0.001]; versus 40% NS dilution [10.4 +- 4.6], [P=0.129]). Hydroxyethyl Starch Derivatives 158-161 fibrinogen beta chain Homo sapiens 69-79 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 17-20 albumin Mus musculus 12-15 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 12-15 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 12-15 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 12-15 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 12-15 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-9 2016 Addition of Alb (HES/Alb) reversed all adverse effects of HES (p < 0.05 vs. HES), restored barrier integrity (p < 0.05 vs. HES) and improved metabolic function of the intestine (p < 0.001 vs. HES; p < 0.05 vs. Alb). Hydroxyethyl Starch Derivatives 58-61 albumin Mus musculus 21-24 26920368-10 2016 Mechanistically, HES/Alb perfusion resulted in an increased phosphorylation of Erk1/2 and Akt kinases (p < 0.001 vs. HES), while Stat5 remained unchanged. Hydroxyethyl Starch Derivatives 17-20 albumin Mus musculus 21-24 26920368-10 2016 Mechanistically, HES/Alb perfusion resulted in an increased phosphorylation of Erk1/2 and Akt kinases (p < 0.001 vs. HES), while Stat5 remained unchanged. Hydroxyethyl Starch Derivatives 17-20 mitogen-activated protein kinase 3 Mus musculus 79-85 26920368-10 2016 Mechanistically, HES/Alb perfusion resulted in an increased phosphorylation of Erk1/2 and Akt kinases (p < 0.001 vs. HES), while Stat5 remained unchanged. Hydroxyethyl Starch Derivatives 17-20 thymoma viral proto-oncogene 1 Mus musculus 90-93 26920368-10 2016 Mechanistically, HES/Alb perfusion resulted in an increased phosphorylation of Erk1/2 and Akt kinases (p < 0.001 vs. HES), while Stat5 remained unchanged. Hydroxyethyl Starch Derivatives 120-123 albumin Mus musculus 21-24 26920368-10 2016 Mechanistically, HES/Alb perfusion resulted in an increased phosphorylation of Erk1/2 and Akt kinases (p < 0.001 vs. HES), while Stat5 remained unchanged. Hydroxyethyl Starch Derivatives 120-123 mitogen-activated protein kinase 3 Mus musculus 79-85 26920368-11 2016 CONCLUSIONS: Albumin supplementation abrogates the adverse effects of HES in the intestine and underlying mechanism may function via phosphorylation of Erk1/2 and Akt. Hydroxyethyl Starch Derivatives 70-73 albumin Mus musculus 13-20 26920368-11 2016 CONCLUSIONS: Albumin supplementation abrogates the adverse effects of HES in the intestine and underlying mechanism may function via phosphorylation of Erk1/2 and Akt. Hydroxyethyl Starch Derivatives 70-73 mitogen-activated protein kinase 3 Mus musculus 152-158 26920368-11 2016 CONCLUSIONS: Albumin supplementation abrogates the adverse effects of HES in the intestine and underlying mechanism may function via phosphorylation of Erk1/2 and Akt. Hydroxyethyl Starch Derivatives 70-73 thymoma viral proto-oncogene 1 Mus musculus 163-166 26920368-12 2016 Albumin containing HES solutions are superior to HES alone and may improve the suitability of HES in the clinic. Hydroxyethyl Starch Derivatives 19-22 albumin Mus musculus 0-7 26920368-12 2016 Albumin containing HES solutions are superior to HES alone and may improve the suitability of HES in the clinic. Hydroxyethyl Starch Derivatives 49-52 albumin Mus musculus 0-7 26920368-12 2016 Albumin containing HES solutions are superior to HES alone and may improve the suitability of HES in the clinic. Hydroxyethyl Starch Derivatives 49-52 albumin Mus musculus 0-7 26920368-0 2016 Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin. Hydroxyethyl Starch Derivatives 40-43 albumin Mus musculus 146-153 26920368-6 2016 RESULTS: HES induced histomorphological damage (p < 0.01 vs. Alb), by trend elevated the amount of luminal intestinal fatty acid binding protein and reduced galactose uptake (p < 0.001 vs. Alb). Hydroxyethyl Starch Derivatives 9-12 albumin Mus musculus 64-67 26920368-6 2016 RESULTS: HES induced histomorphological damage (p < 0.01 vs. Alb), by trend elevated the amount of luminal intestinal fatty acid binding protein and reduced galactose uptake (p < 0.001 vs. Alb). Hydroxyethyl Starch Derivatives 9-12 albumin Mus musculus 195-198 26920368-8 2016 HES also increased the vascular to luminal FITC-dextran transfer (p < 0.001 vs. Alb), pointing towards a fluid shift from the vascular to the luminal and lymphatic compartments during HES perfusion. Hydroxyethyl Starch Derivatives 0-3 albumin Mus musculus 83-86 26454752-9 2015 Due to concerns that high concentrations of HES could affect renal function we tested 0.6% HES/2.5% HSA resulting in significantly poorer CD34 recovery and viability. Hydroxyethyl Starch Derivatives 44-47 CD34 molecule Homo sapiens 138-142 26454752-9 2015 Due to concerns that high concentrations of HES could affect renal function we tested 0.6% HES/2.5% HSA resulting in significantly poorer CD34 recovery and viability. Hydroxyethyl Starch Derivatives 91-94 CD34 molecule Homo sapiens 138-142 26603798-4 2015 The thromboelastographic functional fibrinogen assay showed that the fibrinogen component of clot strength was significantly impaired with haemodilution with HES 130/0.4 compared with haemodilution with NS (whole blood [14.4 +- 4.6 mm] versus 40% HES dilution [3.7 +- 1.9], [P=0.001]; versus 40% NS dilution [10.4 +- 4.6], [P=0.129]). Hydroxyethyl Starch Derivatives 247-250 fibrinogen beta chain Homo sapiens 69-79 26603798-5 2015 These findings suggest that there is little difference between HES or NS in relation to coagulation or platelet function during minor or moderate haemodilution, but at high levels of haemodilution with HES, fibrinogen activity is more impaired compared with NS. Hydroxyethyl Starch Derivatives 202-205 fibrinogen beta chain Homo sapiens 207-217 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 C-X-C motif chemokine ligand 9 Homo sapiens 120-123 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 C-X-C motif chemokine ligand 10 Homo sapiens 125-130 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 complement C3 Homo sapiens 132-135 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 complement C5a receptor 1 Homo sapiens 140-143 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 interleukin 1 beta Homo sapiens 175-183 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 tumor necrosis factor Homo sapiens 185-188 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 C-C motif chemokine ligand 2 Homo sapiens 190-195 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 200-204 24901387-8 2014 Finally, HES-MCs equipped with MPLA, anti-CD40, and anti-DEC205 induced the secretion of TNF-alpha, IL-6 by Kupffer cells (KCs), and IFN-gamma and IL-12p70 by liver dendritic cells (DCs). Hydroxyethyl Starch Derivatives 9-12 tumor necrosis factor Mus musculus 89-98 26438299-0 2015 HES-Mediated Repression of Pten in Caenorhabditis elegans. Hydroxyethyl Starch Derivatives 0-3 phosphatase and tensin homolog Homo sapiens 27-31 25832864-11 2015 The results showed that CK-20 mRNA positive rate in HES 200/0.5 group after surgery was decreased significantly as compared to group HES 130/0.4 (chi (2) = 6.164, P = 0.013). Hydroxyethyl Starch Derivatives 52-55 keratin 20 Homo sapiens 24-29 25832864-11 2015 The results showed that CK-20 mRNA positive rate in HES 200/0.5 group after surgery was decreased significantly as compared to group HES 130/0.4 (chi (2) = 6.164, P = 0.013). Hydroxyethyl Starch Derivatives 133-136 keratin 20 Homo sapiens 24-29 25832864-15 2015 Besides, the expression of GPIIb/IIIa, CD62P and PAR was inhibited more strongly in group HES 200/0.5 than those in group HES 130/0.4. Hydroxyethyl Starch Derivatives 90-93 integrin subunit alpha 2b Homo sapiens 27-32 25832864-15 2015 Besides, the expression of GPIIb/IIIa, CD62P and PAR was inhibited more strongly in group HES 200/0.5 than those in group HES 130/0.4. Hydroxyethyl Starch Derivatives 90-93 selectin P Homo sapiens 39-44 25832864-15 2015 Besides, the expression of GPIIb/IIIa, CD62P and PAR was inhibited more strongly in group HES 200/0.5 than those in group HES 130/0.4. Hydroxyethyl Starch Derivatives 122-125 integrin subunit alpha 2b Homo sapiens 27-32 25627076-2 2015 We hypothesized that patients undergoing radical prostatectomy and receiving HES would be more likely to develop markers of renal failure, such as increasing urinary neutrophil gelatinase-associated lipocalin (u-NGAL), creatinine clearance (C(crea)), and decreasing urine output (UO). Hydroxyethyl Starch Derivatives 77-80 lipocalin 2 Homo sapiens 166-208 25627076-2 2015 We hypothesized that patients undergoing radical prostatectomy and receiving HES would be more likely to develop markers of renal failure, such as increasing urinary neutrophil gelatinase-associated lipocalin (u-NGAL), creatinine clearance (C(crea)), and decreasing urine output (UO). Hydroxyethyl Starch Derivatives 77-80 lipocalin 2 Homo sapiens 212-216 25127210-2 2014 The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associated lipocalin (u-NGAL) in patients with normal renal function during hip arthroplasty. Hydroxyethyl Starch Derivatives 64-67 lipocalin 2 Homo sapiens 134-176 25127210-2 2014 The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associated lipocalin (u-NGAL) in patients with normal renal function during hip arthroplasty. Hydroxyethyl Starch Derivatives 64-67 lipocalin 2 Homo sapiens 180-184 24901387-8 2014 Finally, HES-MCs equipped with MPLA, anti-CD40, and anti-DEC205 induced the secretion of TNF-alpha, IL-6 by Kupffer cells (KCs), and IFN-gamma and IL-12p70 by liver dendritic cells (DCs). Hydroxyethyl Starch Derivatives 9-12 interleukin 6 Mus musculus 100-104 24901387-8 2014 Finally, HES-MCs equipped with MPLA, anti-CD40, and anti-DEC205 induced the secretion of TNF-alpha, IL-6 by Kupffer cells (KCs), and IFN-gamma and IL-12p70 by liver dendritic cells (DCs). Hydroxyethyl Starch Derivatives 9-12 interferon gamma Mus musculus 133-142 24333074-0 2014 A calcium-containing electrolyte-balanced hydroxyethyl starch (HES) solution is associated with higher factor VIII activity than is a non-balanced HES solution, but does not affect von Willebrand factor function or thromboelastometric measurements--results of a model of in vitro haemodilution. Hydroxyethyl Starch Derivatives 63-66 cytochrome c oxidase subunit 8A Homo sapiens 110-114 24333074-8 2014 Prothrombin time ratio (p<=0.002) and factor VIII levels (p=0.001) were better preserved with balanced HES than with non-balanced HES in dilutions >=40%. Hydroxyethyl Starch Derivatives 106-109 cytochrome c oxidase subunit 8A Homo sapiens 48-52 24842200-6 2014 During CPB, COP was reduced by 22% in the HES-group [(16.7 +- 3.9) vs (21.5 +- 2.2) mmHg, P < 0.05] while it was reduced by more than 50% of the pre-CPB value [10.7 +- 2.0 vs (22.7 +- 1.9) mmHg, P < 0.05] in the crystalloid group (P < 0.05 HES-group vs. crystalloid group). Hydroxyethyl Starch Derivatives 42-45 caspase recruitment domain family member 16 Homo sapiens 12-15 25505592-4 2014 This study was performed with the aim of investigating the potential of use hydroxyethyl starch (HES) as a high-molecular weight carrier for anticancer drug (methotrexate, MTX). Hydroxyethyl Starch Derivatives 97-100 metaxin 1 Mus musculus 172-175 24578376-7 2014 The removal of sialic acids by neuraminidase induces iPS-MBMC and hES cells differentiation, prompting an ectoderm commitment. Hydroxyethyl Starch Derivatives 66-69 neuraminidase 1 Homo sapiens 31-44 24753757-6 2014 The pHi of the HES 130/0.4 group was significantly higher than that of the HES 200/0.5 group two hours after skin incision and at the end of surgery (P<0.05). Hydroxyethyl Starch Derivatives 15-18 glucose-6-phosphate isomerase Homo sapiens 4-7