PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3002856-0	1986	Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.	inositol polyphosphates	85-108	adrenoceptor alpha 1D	Homo sapiens	0-7
32839513-3	2021	IMPA1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphatidylinositol signaling pathway.	inositol polyphosphates	102-125	inositol monophosphatase 1	Homo sapiens	0-5
32393577-0	2020	Interplay between PFBC-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis.	inositol polyphosphates	83-106	solute carrier family 20 member 2	Homo sapiens	34-41
32393577-0	2020	Interplay between PFBC-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis.	inositol polyphosphates	83-106	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	46-50
32015686-1	2020	The inositol polyphosphate kinase (IPK) family member ITPKA (inositol 1,4,5-trisphosphate 3-kinase) regulates the levels of many inositol polyphosphates which are important in cellular signaling.	inositol polyphosphates	129-152	inositol-trisphosphate 3-kinase A	Homo sapiens	54-59
32015686-1	2020	The inositol polyphosphate kinase (IPK) family member ITPKA (inositol 1,4,5-trisphosphate 3-kinase) regulates the levels of many inositol polyphosphates which are important in cellular signaling.	inositol polyphosphates	129-152	inositol-trisphosphate 3-kinase A	Homo sapiens	61-98
31189594-0	2019	Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton"s tyrosine kinase.	inositol polyphosphates	0-23	Bruton tyrosine kinase	Homo sapiens	90-114
31394817-0	2019	Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?	inositol polyphosphates	4-27	COP9 signalosome subunit 8	Homo sapiens	93-97
31221192-1	2019	Inositol polyphosphate multikinase (IPMK), the key enzyme responsible for the synthesis of higher inositol polyphosphates and phosphatidylinositol 3, 4, 5-trisphosphate, is known to mediate various biological events, such as cellular growth and metabolism.	inositol polyphosphates	98-121	inositol polyphosphate multikinase	Mus musculus	0-34
31221192-1	2019	Inositol polyphosphate multikinase (IPMK), the key enzyme responsible for the synthesis of higher inositol polyphosphates and phosphatidylinositol 3, 4, 5-trisphosphate, is known to mediate various biological events, such as cellular growth and metabolism.	inositol polyphosphates	98-121	inositol polyphosphate multikinase	Mus musculus	36-40
25349427-1	2014	Inositol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1-3).	inositol polyphosphates	0-23	inositol hexakisphosphate kinase 1	Homo sapiens	150-157
30692248-1	2019	Inositol polyphosphate multikinase (IPMK), the key enzyme for the biosynthesis of higher inositol polyphosphates and phosphatidylinositol 3,4,5-trisphosphate, also acts as a versatile signaling player in regulating tissue growth and metabolism.	inositol polyphosphates	89-112	inositol polyphosphate multikinase	Mus musculus	0-34
30692248-1	2019	Inositol polyphosphate multikinase (IPMK), the key enzyme for the biosynthesis of higher inositol polyphosphates and phosphatidylinositol 3,4,5-trisphosphate, also acts as a versatile signaling player in regulating tissue growth and metabolism.	inositol polyphosphates	89-112	inositol polyphosphate multikinase	Mus musculus	36-40
26446451-5	2016	As it is known that PP-IP4 regulates telomere length through Tel1, inositol polyphosphates, cell cycle and telomere length were determined in tel1Delta cells.	inositol polyphosphates	67-90	peptidylprolyl isomerase A pseudogene 14	Homo sapiens	20-26
29617377-1	2018	Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) regulates the level of the inositol polyphosphates, inositol trisphosphate (IP3) and inositol tetrakisphosphate to modulate cellular signaling and intracellular calcium homeostasis in the central nervous system.	inositol polyphosphates	76-99	inositol 1,4,5-trisphosphate 3-kinase A	Mus musculus	0-39
29617377-1	2018	Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) regulates the level of the inositol polyphosphates, inositol trisphosphate (IP3) and inositol tetrakisphosphate to modulate cellular signaling and intracellular calcium homeostasis in the central nervous system.	inositol polyphosphates	76-99	inositol 1,4,5-trisphosphate 3-kinase A	Mus musculus	41-47
27038811-3	2016	Multiple inositol polyphosphate phosphatase 1 (Minpp1) is the only known endoplasmic reticulum (ER) luminal enzyme that hydrolyzes various inositol polyphosphates in vitro as well as in vivo conditions.	inositol polyphosphates	139-162	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	0-45
27038811-3	2016	Multiple inositol polyphosphate phosphatase 1 (Minpp1) is the only known endoplasmic reticulum (ER) luminal enzyme that hydrolyzes various inositol polyphosphates in vitro as well as in vivo conditions.	inositol polyphosphates	139-162	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	47-53
26682649-2	2016	Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate.	inositol polyphosphates	116-139	inositol polyphosphate multikinase	Homo sapiens	0-34
26682649-2	2016	Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate.	inositol polyphosphates	116-139	inositol polyphosphate multikinase	Homo sapiens	36-40
22475172-3	2012	The binding of Ca(2+) to the C2A domain activates the exocytosis of secretory vesicles, while the binding of inositol polyphosphates (IP4-IP6) to the C2B domain inhibits this process.	inositol polyphosphates	109-132	secretoglobin family 2B member 3, pseudogene	Homo sapiens	150-153
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	inositol polyphosphates	53-76	gap junction protein alpha 1	Homo sapiens	97-101
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	inositol polyphosphates	53-76	fibroblast growth factor 2	Homo sapiens	156-160
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	inositol polyphosphates	53-76	gap junction protein alpha 1	Homo sapiens	311-315
23381992-3	2013	In Saccharomyces cerevisiae, Plc1-derived IP(3) is a substrate for the inositol polyphosphate kinase Arg82, which converts IP(3) to more complex inositol polyphosphates.	inositol polyphosphates	145-168	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	29-33
23381992-3	2013	In Saccharomyces cerevisiae, Plc1-derived IP(3) is a substrate for the inositol polyphosphate kinase Arg82, which converts IP(3) to more complex inositol polyphosphates.	inositol polyphosphates	145-168	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	101-106
19459978-1	2009	In budding yeasts, phosphoinositide-specific phospholipase C (Plc1p encoded by PLC1 gene) and several inositol polyphosphate kinases represent a nuclear pathway for synthesis of inositol polyphosphates (InsPs), which are involved in several aspects of DNA and RNA metabolism, including transcriptional regulation.	inositol polyphosphates	178-201	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	62-67
21205029-0	2011	Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana.	inositol polyphosphates	42-65	RNI-like superfamily protein	Arabidopsis thaliana	28-32
21402086-3	2011	Inositol polyphosphates (InsPPs) such as Inositol 1,3,4,5,6-pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) bind to Ca2+-binding C2B domain of Syt I and II, and inhibit transmitter release.	inositol polyphosphates	0-23	synaptotagmin 1	Homo sapiens	159-171
19459978-1	2009	In budding yeasts, phosphoinositide-specific phospholipase C (Plc1p encoded by PLC1 gene) and several inositol polyphosphate kinases represent a nuclear pathway for synthesis of inositol polyphosphates (InsPs), which are involved in several aspects of DNA and RNA metabolism, including transcriptional regulation.	inositol polyphosphates	178-201	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	79-83
12226109-9	2002	Collectively our results provide a molecular basis for the synthesis of higher inositol polyphosphates in plants through multiple routes and indicate that the 6-/3-/5-kinase activities found in plant extracts may be encoded by the IPK2 gene class.	inositol polyphosphates	79-102	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	231-235
19205744-4	2009	The mechanism of Plc1p"s involvement in kinetochore activity was not initially obvious; however, a testable hypothesis emerged with the discovery of the role of inositol polyphosphates (InsPs), produced by a Plc1p-dependent pathway, in the regulation of chromatin-remodeling complexes.	inositol polyphosphates	161-184	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	17-22
19205744-4	2009	The mechanism of Plc1p"s involvement in kinetochore activity was not initially obvious; however, a testable hypothesis emerged with the discovery of the role of inositol polyphosphates (InsPs), produced by a Plc1p-dependent pathway, in the regulation of chromatin-remodeling complexes.	inositol polyphosphates	161-184	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	208-213
17595165-2	2007	We explored the potential roles for inositol polyphosphates as mediators of Wnt signaling in the canonical path-way.	inositol polyphosphates	36-59	wingless-type MMTV integration site family, member 3A	Mus musculus	76-79
17595165-3	2007	Wnt3a triggers G-protein-linked phosphatidylinositol signaling, transiently generating inositol polyphosphates, especially inositol pentakisphosphate (IP(5)) accumulation.	inositol polyphosphates	87-110	Wnt family member 3A	Rattus norvegicus	0-5
17429070-9	2007	The results thus provide evidence that Plc1p and inositol polyphosphates affect derepression of Sko1p-Ssn6p-Tup1p-controlled genes by a mechanism that involves recruitment of the SAGA complex and TATA-binding protein.	inositol polyphosphates	49-72	Sko1p	Saccharomyces cerevisiae S288C	96-101
17429070-9	2007	The results thus provide evidence that Plc1p and inositol polyphosphates affect derepression of Sko1p-Ssn6p-Tup1p-controlled genes by a mechanism that involves recruitment of the SAGA complex and TATA-binding protein.	inositol polyphosphates	49-72	transcription regulator CYC8	Saccharomyces cerevisiae S288C	102-107
17429070-9	2007	The results thus provide evidence that Plc1p and inositol polyphosphates affect derepression of Sko1p-Ssn6p-Tup1p-controlled genes by a mechanism that involves recruitment of the SAGA complex and TATA-binding protein.	inositol polyphosphates	49-72	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	108-113
17429070-9	2007	The results thus provide evidence that Plc1p and inositol polyphosphates affect derepression of Sko1p-Ssn6p-Tup1p-controlled genes by a mechanism that involves recruitment of the SAGA complex and TATA-binding protein.	inositol polyphosphates	49-72	TATA-binding protein	Saccharomyces cerevisiae S288C	196-216
12963730-1	2003	Multiple inositol polyphosphate phosphatase (MIPP) is an enzyme that, in vitro, has the interesting property of degrading higher inositol polyphosphates to the Ca2+ second messenger, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), independently of inositol lipid breakdown.	inositol polyphosphates	129-152	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	45-49
12586875-5	2003	The purified recombinant ZmIpk protein has kinase activity on several inositol polyphosphates, including Ins(1,3,4)P(3), Ins(3,5,6)P(3), Ins(3,4,5,6)P(4), and Ins(1,2,5,6)P(4).	inositol polyphosphates	70-93	inositol-tetrakisphosphate 1-kinase 1	Zea mays	25-30
16750654-2	2006	One of the best examined nuclear lipid pathways is the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) by PLC resulting in activation of nuclear PKC and production of inositol polyphosphates.	inositol polyphosphates	183-206	serpin family A member 4	Homo sapiens	108-111
16750654-2	2006	One of the best examined nuclear lipid pathways is the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) by PLC resulting in activation of nuclear PKC and production of inositol polyphosphates.	inositol polyphosphates	183-206	heparan sulfate proteoglycan 2	Homo sapiens	122-125
16750654-5	2006	This review focuses on the role of specifically PI4,5P(2) in the nucleus as a second messenger as well as a precursor for PI3,4,5P3, inositol polyphosphates and diacylglycerol.	inositol polyphosphates	133-156	serpin family A member 4	Homo sapiens	48-51
16525636-5	2006	ITPKA phosphorylates inositol 1,4,5-trisphosphate, which regulates the calcium (Ca2+) level within the cell by releasing Ca2+ from intracellular stores, and is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling.	inositol polyphosphates	219-242	inositol-trisphosphate 3-kinase A	Homo sapiens	0-5
16525636-10	2006	These data suggest that ITPKA may be related to carcinogenesis by the modulation of inositol polyphosphates and Ca2+ homeostasis and that ITPKA may be a potential novel molecular target, biomarker, parameter, or all of these of cellular differentiation and of intracellular Ca2+ homeostatic characteristics in clinical medicine.	inositol polyphosphates	84-107	inositol-trisphosphate 3-kinase A	Homo sapiens	24-29
10938126-12	2000	Yet, depletion of cellular inositol polyphosphates during erythropoiesis emerges as an additional physiological activity of Minpp1; loss of this enzyme activity in erythrocytes from Minpp1-deficient mice was accompanied by upregulation of a novel, substitutive inositol polyphosphate phosphatase.	inositol polyphosphates	27-50	multiple inositol polyphosphate histidine phosphatase 1	Mus musculus	124-130
11438518-9	2001	Synaptotagmin-I binding is abolished by mutations in two positively charged amino acids in the C(2) domains of RIM and by the addition of inositol polyphosphates.	inositol polyphosphates	138-161	synaptotagmin 1	Homo sapiens	0-15
11312102-5	2001	Thus, tyrosine phosphorylation of phospholipase Cgamma, and accumulation of inositol polyphosphates were efficiently transduced in the VEGFR-1/2 cells whereas cells expressing VEGFR-1 responded poorly in these assays.	inositol polyphosphates	76-99	fms related receptor tyrosine kinase 1	Homo sapiens	135-142
10938126-12	2000	Yet, depletion of cellular inositol polyphosphates during erythropoiesis emerges as an additional physiological activity of Minpp1; loss of this enzyme activity in erythrocytes from Minpp1-deficient mice was accompanied by upregulation of a novel, substitutive inositol polyphosphate phosphatase.	inositol polyphosphates	27-50	multiple inositol polyphosphate histidine phosphatase 1	Mus musculus	182-188
9114007-0	1997	Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C. D-myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6), formed via complex pathways of inositol phosphate metabolism, composes the main bulk of inositol polyphosphates in the cell.	inositol polyphosphates	278-301	insulin	Homo sapiens	94-101
10933784-0	2000	Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides.	inositol polyphosphates	102-125	secretoglobin family 2B member 3, pseudogene	Homo sapiens	68-71
10933784-2	2000	It contains two domains homologous to the C2 regulatory region of protein kinase C. The C2A domain acts as a calcium sensor, while the C2B domain has high affinity for inositol polyphosphates (InsP(n)()s) and phosphoinositide polyphosphates (PtdInsP(n)()s).	inositol polyphosphates	168-191	secretoglobin family 2B member 3, pseudogene	Homo sapiens	135-138
10834940-8	2000	Thus, we propose that specific inositol polyphosphates inhibit PI3-K by competing with PtdIns(3,4, 5)P(3)-binding PH domains and that this occurs mainly at the level of the downstream PI3-K target, PKB/Akt.	inositol polyphosphates	31-54	AKT serine/threonine kinase 1	Homo sapiens	198-205
9393882-8	1997	However, transformation by BCR/ABL was associated with a reduced SHIP protein expression, which could further affect the accumulation of various inositol polyphosphates in these leukemic cells.	inositol polyphosphates	145-168	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	27-34
9393882-8	1997	However, transformation by BCR/ABL was associated with a reduced SHIP protein expression, which could further affect the accumulation of various inositol polyphosphates in these leukemic cells.	inositol polyphosphates	145-168	inositol polyphosphate-5-phosphatase D	Homo sapiens	65-69
10336465-0	1999	Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates.	inositol polyphosphates	153-176	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	94-102
10336465-6	1999	We used nuclear magnetic resonance spectroscopy and biosensor experiments to investigate interactions between the p85alpha SH2 domains and phosphoinositides or inositol polyphosphates.	inositol polyphosphates	160-183	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	114-122
10336465-10	1999	We show that the p85alpha SH2 domain Tyr(P) binding pockets indiscriminately accommodate phosphoinositides and inositol polyphosphates.	inositol polyphosphates	111-134	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	17-25
8186462-0	1994	Inositol polyphosphates are not increased by overexpression of Ins(1,4,5)P3 3-kinase but show cell-cycle dependent changes in growth factor-stimulated fibroblasts.	inositol polyphosphates	0-23	myotrophin	Rattus norvegicus	126-139
7802629-5	1994	The present finding that InsP4 binds strongly to synaptotagmin II suggests an important role for inositol polyphosphates in the regulation of neurotransmitter release.	inositol polyphosphates	97-120	synaptotagmin 2	Rattus norvegicus	49-65
7550072-5	1995	Bradykinin also stimulated formation of inositol polyphosphates including 1,4,5-IP3.	inositol polyphosphates	40-63	kininogen 1	Homo sapiens	0-10
7845474-3	1994	A possible link between MH induced by 5-HT2A receptor agonists and halothane could be an increase of second messengers such as phosphoinositides (inositol polyphosphates), which have recently been implicated in the abnormal regulation of skeletal muscle calcium release in MH.	inositol polyphosphates	146-169	5-hydroxytryptamine receptor 2A	Sus scrofa	38-53
8172600-1	1994	The roles of heterotrimeric GTP-binding regulatory proteins (G-proteins) and inositol polyphosphates in the mechanism by which vasopressin stimulates Ca2+ inflow in hepatocytes were investigated by using single cells loaded with fura2 by microinjection.	inositol polyphosphates	77-100	arginine vasopressin	Rattus norvegicus	127-138
8255989-10	1993	These results suggest that the formation of inositol polyphosphates may be regulated by two mechanisms, i.e. Ca2+ uptake-dependent mechanisms represented by high K+, and Ca2+ uptake-independent mechanisms represented by Ang II.	inositol polyphosphates	44-67	angiotensinogen	Homo sapiens	220-226
8393878-2	1993	Yet, PAF-stimulated diglycerides (DG) are still elevated at time points where inositol polyphosphates have returned to basal levels.	inositol polyphosphates	78-101	PCNA clamp associated factor	Rattus norvegicus	5-8
8471631-8	1993	BAC (C approximately 12) and BAC (C14) inhibited the generation of inositol polyphosphates induced by GTP gamma S. BAC (C approximately 12) and TAB (C14) inhibited the mastoparan-stimulated GTPase activity from mast-cell Gi-like proteins.	inositol polyphosphates	67-90	anti-Mullerian hormone receptor type 2	Rattus norvegicus	34-37
8471631-8	1993	BAC (C approximately 12) and BAC (C14) inhibited the generation of inositol polyphosphates induced by GTP gamma S. BAC (C approximately 12) and TAB (C14) inhibited the mastoparan-stimulated GTPase activity from mast-cell Gi-like proteins.	inositol polyphosphates	67-90	anti-Mullerian hormone receptor type 2	Rattus norvegicus	149-152
1290415-4	1992	Furthermore, we observed that antigen stimulation caused a marked increase in inositol polyphosphates production, which derived from the tyrosine phosphorylation of phospholipase C-gamma in RBL-2H3 cells.	inositol polyphosphates	78-101	RB transcriptional corepressor like 2	Rattus norvegicus	190-195
1373170-5	1992	C3a stimulated the generation of inositol polyphosphates that was inhibited by either pertussis toxin or benzalkonium chloride.	inositol polyphosphates	33-56	complement C3	Homo sapiens	0-3
1514647-0	1992	Time course of thrombin-induced increase in endothelial permeability: relationship to Ca2+i and inositol polyphosphates.	inositol polyphosphates	96-119	coagulation factor II, thrombin	Bos taurus	15-23
1324159-2	1992	ET-1 induced a rapid stimulation of phosphoinositide hydrolysis in populations of granulosa cells, as inferred by the rapid appearance of soluble inositol polyphosphates in response to ET-1 exposure.	inositol polyphosphates	146-169	endothelin-1	Sus scrofa	0-4
1324159-2	1992	ET-1 induced a rapid stimulation of phosphoinositide hydrolysis in populations of granulosa cells, as inferred by the rapid appearance of soluble inositol polyphosphates in response to ET-1 exposure.	inositol polyphosphates	146-169	endothelin-1	Sus scrofa	185-189
1333166-1	1992	The findings described above illustrate how the src kinase can influence several new pathways of inositol phosphate metabolism, both at the membrane level with the production of novel D-3 phosphoinositides and the activation of PI-3 kinase, and at the cytosolic level by altering the expression of certain inositol polyphosphates, in particular Ins(1,4,5,6)P4.	inositol polyphosphates	306-329	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	48-51
1403848-1	1992	We have examined the ability of recombinant human epidermal growth factor (EGF) and bradykinin (BK) to stimulate formation of inositol polyphosphates and sn-1,2-diacylglycerol (DAG), and mobilize intracellular Ca2+ ([Ca2+]i) in adult human keratinocytes (KC).	inositol polyphosphates	126-149	epidermal growth factor	Homo sapiens	50-73
1403848-1	1992	We have examined the ability of recombinant human epidermal growth factor (EGF) and bradykinin (BK) to stimulate formation of inositol polyphosphates and sn-1,2-diacylglycerol (DAG), and mobilize intracellular Ca2+ ([Ca2+]i) in adult human keratinocytes (KC).	inositol polyphosphates	126-149	epidermal growth factor	Homo sapiens	75-78
1403848-1	1992	We have examined the ability of recombinant human epidermal growth factor (EGF) and bradykinin (BK) to stimulate formation of inositol polyphosphates and sn-1,2-diacylglycerol (DAG), and mobilize intracellular Ca2+ ([Ca2+]i) in adult human keratinocytes (KC).	inositol polyphosphates	126-149	kininogen 1	Homo sapiens	84-94
1403848-1	1992	We have examined the ability of recombinant human epidermal growth factor (EGF) and bradykinin (BK) to stimulate formation of inositol polyphosphates and sn-1,2-diacylglycerol (DAG), and mobilize intracellular Ca2+ ([Ca2+]i) in adult human keratinocytes (KC).	inositol polyphosphates	126-149	kininogen 1	Homo sapiens	96-98
2557820-2	1989	Bradykinin caused a rapid and transient 3-fold increase in the formation of inositol polyphosphates in BAEC.	inositol polyphosphates	76-99	kininogen 1	Homo sapiens	0-10
2322266-5	1990	Furthermore, both ANG II and ANG III increased the production of inositol polyphosphates in a dose-dependent manner with ED50 values of 145 nM and 11 nM, respectively.	inositol polyphosphates	65-88	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	18-24
2322266-5	1990	Furthermore, both ANG II and ANG III increased the production of inositol polyphosphates in a dose-dependent manner with ED50 values of 145 nM and 11 nM, respectively.	inositol polyphosphates	65-88	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	18-21
2017158-3	1991	In rat liver, angiotensin II can both activate phospholipase C, generating inositol polyphosphates and raising internal calcium, and inhibit adenylate cyclase.	inositol polyphosphates	75-98	angiotensinogen	Rattus norvegicus	14-28
1900389-2	1991	Endothelin-1 (ET) synergistically released inositol polyphosphates in the presence of the stimulatory GTP analogue guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) in permeabilized cells.	inositol polyphosphates	43-66	endothelin 1	Rattus norvegicus	0-12
1900389-2	1991	Endothelin-1 (ET) synergistically released inositol polyphosphates in the presence of the stimulatory GTP analogue guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) in permeabilized cells.	inositol polyphosphates	43-66	endothelin 1	Rattus norvegicus	14-16
1982181-4	1990	Inositol polyphosphates appear also to be involved in the activation of Ca2+ entry, but the mechanism by which this is accomplished is less clear.	inositol polyphosphates	0-23	carbonic anhydrase 2	Homo sapiens	72-75
1982181-6	1990	The evidence for this model comes from the demonstration, by diverse strategies, that the same Ca2+ entry mechanism normally activated by Ca2(+)-mobilizing agonists can be equally well triggered by depletion of the intracellular Ca2+ pool, even in the absence of receptor activation or elevated cellular levels of inositol polyphosphates.	inositol polyphosphates	314-337	carbonic anhydrase 2	Homo sapiens	95-98
1982181-6	1990	The evidence for this model comes from the demonstration, by diverse strategies, that the same Ca2+ entry mechanism normally activated by Ca2(+)-mobilizing agonists can be equally well triggered by depletion of the intracellular Ca2+ pool, even in the absence of receptor activation or elevated cellular levels of inositol polyphosphates.	inositol polyphosphates	314-337	carbonic anhydrase 2	Homo sapiens	138-141
1982181-6	1990	The evidence for this model comes from the demonstration, by diverse strategies, that the same Ca2+ entry mechanism normally activated by Ca2(+)-mobilizing agonists can be equally well triggered by depletion of the intracellular Ca2+ pool, even in the absence of receptor activation or elevated cellular levels of inositol polyphosphates.	inositol polyphosphates	314-337	carbonic anhydrase 2	Homo sapiens	138-141
3111461-0	1987	Subsecond and second changes in inositol polyphosphates in GH4C1 cells induced by thyrotropin-releasing hormone.	inositol polyphosphates	32-55	thyrotropin releasing hormone	Rattus norvegicus	82-111
3263806-0	1988	PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line.	inositol polyphosphates	13-36	parathyroid hormone	Rattus norvegicus	0-3
3499898-5	1987	Labelling of platelets with [32P]Pi, followed by h.p.l.c., was used to measure thrombin-induced changes in the three inositol polyphosphates.	inositol polyphosphates	117-140	coagulation factor II, thrombin	Homo sapiens	79-87
2885225-4	1987	AlCl3 enhanced the NaF-stimulated release of inositol polyphosphates.	inositol polyphosphates	45-68	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
2885225-5	1987	Optimum concentrations of NaF and AlCl3 produced 1.5-fold more inositol polyphosphates than that produced by optimum concentration of GTP gamma S. OKT3 monoclonal antibody, an antibody against the T-cell receptor complex, did not stimulate the inositol polyphosphate formation by JURKAT membranes even in the presence of GTP, although the antibody at the concentrations used markedly stimulated the hydrolysis of polyphosphoinositides in intact JURKAT cells.	inositol polyphosphates	63-86	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
3152162-0	1988	Control of glomerulosa cell function by angiotensin II: transduction by G-proteins and inositol polyphosphates.	inositol polyphosphates	87-110	angiotensinogen	Rattus norvegicus	40-54
3111461-1	1987	It has been demonstrated previously that thyrotropin-releasing hormone (TRH) induces changes in inositol polyphosphates in the GH3 and GH4C1 strains of rat pituitary cells within 2.5-5.0 s. TRH also causes a rapid rise in cytosolic free calcium concentration ([Ca2+]i) in these cells which is due largely to redistribution of cellular calcium stores.	inositol polyphosphates	96-119	thyrotropin releasing hormone	Rattus norvegicus	41-70
3111461-1	1987	It has been demonstrated previously that thyrotropin-releasing hormone (TRH) induces changes in inositol polyphosphates in the GH3 and GH4C1 strains of rat pituitary cells within 2.5-5.0 s. TRH also causes a rapid rise in cytosolic free calcium concentration ([Ca2+]i) in these cells which is due largely to redistribution of cellular calcium stores.	inositol polyphosphates	96-119	thyrotropin releasing hormone	Rattus norvegicus	72-75
3111461-1	1987	It has been demonstrated previously that thyrotropin-releasing hormone (TRH) induces changes in inositol polyphosphates in the GH3 and GH4C1 strains of rat pituitary cells within 2.5-5.0 s. TRH also causes a rapid rise in cytosolic free calcium concentration ([Ca2+]i) in these cells which is due largely to redistribution of cellular calcium stores.	inositol polyphosphates	96-119	thyrotropin releasing hormone	Rattus norvegicus	190-193
3030297-6	1987	Furthermore, we have examined five other cell lines that overexpress the EGF receptor and find that EGF treatment induces formation of inositol polyphosphates in those cell lines also.	inositol polyphosphates	135-158	epidermal growth factor receptor	Homo sapiens	73-85
3030297-6	1987	Furthermore, we have examined five other cell lines that overexpress the EGF receptor and find that EGF treatment induces formation of inositol polyphosphates in those cell lines also.	inositol polyphosphates	135-158	epidermal growth factor	Homo sapiens	73-76