PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28476069-3	2017	Here, we show for the first time that a diterpene with a lathyrane skeleton can also activate PKC and promote NPC proliferation.	Diterpenes	40-49	protein kinase C, beta	Mus musculus	94-97
28718638-0	2017	Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene.	Diterpenes	93-102	opioid receptor kappa 1	Homo sapiens	18-39
28915648-4	2017	Here we used a combination of oridonin (natural tetracycline diterpenoid), which has been shown to exhibit anti-RUNX1-ETO activity, and ERK2 kinase inhibitors.	Diterpenes	61-72	RUNX family transcription factor 1	Homo sapiens	112-117
28915648-4	2017	Here we used a combination of oridonin (natural tetracycline diterpenoid), which has been shown to exhibit anti-RUNX1-ETO activity, and ERK2 kinase inhibitors.	Diterpenes	61-72	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	118-121
27464306-10	2017	CONCLUSION AND IMPLICATIONS: In summary, we propose that the combined inhibition of mPGES-1 and 5-LO by CS and CA essentially contributes to the bioactivity of these diterpenoids.	Diterpenes	166-178	prostaglandin E synthase	Mus musculus	84-97
27412850-0	2017	In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.	Diterpenes	55-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	154-169
27412850-0	2017	In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.	Diterpenes	55-66	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	174-201
27412850-2	2017	The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A (PAAH) was studied in vitro using human liver microsomes (HLM) and recombinant UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) enzymes.	Diterpenes	40-51	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	306-333
27412850-2	2017	The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A (PAAH) was studied in vitro using human liver microsomes (HLM) and recombinant UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) enzymes.	Diterpenes	40-51	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	335-338
27412850-2	2017	The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A (PAAH) was studied in vitro using human liver microsomes (HLM) and recombinant UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) enzymes.	Diterpenes	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	344-359
27412850-2	2017	The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A (PAAH) was studied in vitro using human liver microsomes (HLM) and recombinant UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) enzymes.	Diterpenes	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	361-364
28140586-3	2017	These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterpene, suggesting that these fungi might produce more elaborate diterpenoids.	Diterpenes	115-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-47
28068628-0	2017	Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.	Diterpenes	16-25	cyclin dependent kinase inhibitor 2A	Homo sapiens	136-142
28068628-0	2017	Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.	Diterpenes	16-25	RB transcriptional corepressor 1	Homo sapiens	144-147
28068628-0	2017	Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.	Diterpenes	16-25	MDM2 proto-oncogene	Homo sapiens	149-153
28068628-0	2017	Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.	Diterpenes	16-25	tumor protein p53	Homo sapiens	158-161
28395199-2	2017	A series of prodrugs possessing a variety of cytotoxic diterpenoids (oridonin and its analogues) as the leaving groups activated by NQO1 were synthesized by functionalization of 3-(hydroxymethyl)indolequinone, which is a good substrate of NQO1.	Diterpenes	55-67	NAD(P)H quinone dehydrogenase 1	Homo sapiens	132-136
28288319-0	2017	Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption.	Diterpenes	47-56	TNF superfamily member 11	Homo sapiens	88-93
28240909-0	2017	alpha-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.	Diterpenes	50-62	sucrase-isomaltase	Homo sapiens	0-17
28140586-3	2017	These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterpene, suggesting that these fungi might produce more elaborate diterpenoids.	Diterpenes	115-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-52
28140586-3	2017	These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterpene, suggesting that these fungi might produce more elaborate diterpenoids.	Diterpenes	183-195	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-47
28140586-3	2017	These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterpene, suggesting that these fungi might produce more elaborate diterpenoids.	Diterpenes	183-195	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-52
28208826-4	2017	The main effective components of Aconitum plants are diterpenoid alkaloids-which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids-are reportedly some of the most promising, naturally abundant compounds for treating cancer.	Diterpenes	53-64	Bardet-Biedl syndrome 9	Homo sapiens	98-101
28011619-2	2017	Here we report that the recently discovered natural diterpenoid isoforretin A (IsoA) significantly inhibits Trx1 activity and mediates anticancer effects in multiple preclinical settings.	Diterpenes	52-63	thioredoxin 1	Mus musculus	108-112
27940262-0	2017	The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.	Diterpenes	31-43	epidermal growth factor receptor	Homo sapiens	88-92
27816453-3	2017	Glaucocalyxin A (GLA), an ent-Kaurane diterpenoid, has been demonstrated to exert anti-inflammatory, anti-neoplastic and anti-platelet activities.	Diterpenes	38-49	galactosidase, alpha	Mus musculus	17-20
28952250-1	2017	Geranylgeranyl pyrophosphate synthase enzyme is one of the key enzymes in the synthesis pathway of diterpenoid.	Diterpenes	99-110	geranylgeranyl diphosphate synthase 1	Homo sapiens	0-37
27639426-6	2016	Andrographolide, a natural diterpenoid, promoted the activation of the Akt/mTOR signaling by downregulating PTEN and suppressed autophagy, which subsequently resensitized the resistant cells to cisplatin-mediated apoptosis.	Diterpenes	27-38	AKT serine/threonine kinase 1	Homo sapiens	71-74
29199243-0	2017	Daphnane and Phorbol Diterpenes, Anti-neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne genkwa.	Diterpenes	21-31	nuclear receptor subfamily 4, group A, member 2	Mus musculus	71-76
27863415-0	2016	Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.	Diterpenes	108-119	BCL2 associated X, apoptosis regulator	Homo sapiens	144-147
29199243-5	2017	Thus, the daphnane-type and phorbol-type diterpenes had anti-neuroinflammatory activity with Nurr1 activation and could be responsible for the anti-PD effect of the roots and stems of D. genkwa.	Diterpenes	41-51	nuclear receptor subfamily 4, group A, member 2	Mus musculus	93-98
27352383-0	2017	Intermedin A, a New Labdane Diterpene Isolated from Alpinia intermedia, Prolonged the Survival Time of P-388D1 Tumor-Bearing CDF1 Mice.	Diterpenes	28-37	adrenomedullin 2	Homo sapiens	0-10
27352383-4	2017	Two new labdane diterpene derivatives, intermedin A (1) and intermedin B (2), and coronarin E (3) were isolated from the n-hexane layer of A. intermedia.	Diterpenes	16-25	adrenomedullin 2	Homo sapiens	39-49
27639426-6	2016	Andrographolide, a natural diterpenoid, promoted the activation of the Akt/mTOR signaling by downregulating PTEN and suppressed autophagy, which subsequently resensitized the resistant cells to cisplatin-mediated apoptosis.	Diterpenes	27-38	mechanistic target of rapamycin kinase	Homo sapiens	75-79
27508308-0	2016	Boesenberols, Pimarane Diterpenes with TRAIL-Resistance-Overcoming Activity from Boesenbergia pandurata.	Diterpenes	23-33	TNF superfamily member 10	Homo sapiens	39-44
27570243-0	2016	Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS.	Diterpenes	10-22	nitric oxide synthase 2, inducible	Mus musculus	113-117
27004724-2	2016	from East China Sea resulted in the isolation of eight eunicellin diterpenoids including two new ones, muricellins A-B (1, 2).	Diterpenes	66-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	16-19
27240278-0	2016	neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells.	Diterpenes	14-26	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	Diterpenes	11-20	cyclin D1	Homo sapiens	75-84
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	Diterpenes	11-20	mitogen-activated protein kinase 3	Homo sapiens	113-119
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	Diterpenes	11-20	mitogen-activated protein kinase 8	Homo sapiens	121-124
27526327-0	2016	Ceylonamides A-F, Nitrogenous Spongian Diterpenes That Inhibit RANKL-Induced Osteoclastogenesis, from the Marine Sponge Spongia ceylonensis.	Diterpenes	39-49	TNF superfamily member 11	Homo sapiens	63-68
27267997-3	2016	In this study, we demonstrate that carnosic acid, a benzenediol diterpene, binds the ligand-binding domain of the AR and degrades the AR via endoplasmic reticulum (ER) stress-mediated proteasomal degradative pathway.	Diterpenes	64-73	androgen receptor	Homo sapiens	114-116
27317373-1	2016	Carnosic acid (CA), a phenolic diterpene isolated from Rosmarinus officinalis, has been shown to activate nuclear transcription factor E2-related factor 2 (Nrf2), which plays a central role in cytoprotective responses to oxidative and electrophilic stress.	Diterpenes	31-40	NFE2 like bZIP transcription factor 2	Homo sapiens	156-160
30725559-1	2016	Three new daphnane diterpenoids, altadaphnans A-C (1 - 3), have been isolated from the aerial parts of Ddphne altaica, together with 7 known daphnane diterpenoids.	Diterpenes	19-31	adenylate cyclase 3	Homo sapiens	46-56
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	tumor necrosis factor	Mus musculus	120-129
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	chemokine (C-X-C motif) ligand 10	Mus musculus	194-200
27154204-5	2016	Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha.	Diterpenes	29-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-77
27154204-5	2016	Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha.	Diterpenes	29-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	chemokine (C-C motif) ligand 5	Mus musculus	202-206
27154204-5	2016	Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha.	Diterpenes	29-31	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	133-145
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	chemokine (C-X-C motif) ligand 1	Mus musculus	194-199
27154204-5	2016	Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha.	Diterpenes	29-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-189
27154204-5	2016	Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha.	Diterpenes	29-31	tumor necrosis factor	Mus musculus	250-259
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	interleukin 1 receptor, type II	Mus musculus	258-263
27154204-6	2016	Furthermore, DT, probably through p38 signalling, induced transcriptional activation of genes containing activator protein 1 (AP-1)-binding elements.	Diterpenes	13-15	mitogen-activated protein kinase 14	Mus musculus	34-37
27154204-6	2016	Furthermore, DT, probably through p38 signalling, induced transcriptional activation of genes containing activator protein 1 (AP-1)-binding elements.	Diterpenes	13-15	jun proto-oncogene	Mus musculus	105-124
27154204-6	2016	Furthermore, DT, probably through p38 signalling, induced transcriptional activation of genes containing activator protein 1 (AP-1)-binding elements.	Diterpenes	13-15	jun proto-oncogene	Mus musculus	126-130
27154204-7	2016	Inhibition of p38 prevented IL1r2 mRNA expression in endothelium incubated with DT alone or in combination with LPS or TNF-alpha.	Diterpenes	80-82	mitogen-activated protein kinase 14	Mus musculus	14-17
27154204-7	2016	Inhibition of p38 prevented IL1r2 mRNA expression in endothelium incubated with DT alone or in combination with LPS or TNF-alpha.	Diterpenes	80-82	interleukin 1 receptor, type II	Mus musculus	28-33
27154204-9	2016	Additionally, DT reduced the expression of the endothelial adhesion molecules E-selectin, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) after activation.	Diterpenes	14-16	selectin, endothelial cell	Mus musculus	78-88
27154204-9	2016	Additionally, DT reduced the expression of the endothelial adhesion molecules E-selectin, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) after activation.	Diterpenes	14-16	vascular cell adhesion molecule 1	Mus musculus	90-123
27154204-9	2016	Additionally, DT reduced the expression of the endothelial adhesion molecules E-selectin, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) after activation.	Diterpenes	14-16	vascular cell adhesion molecule 1	Mus musculus	125-131
27154204-9	2016	Additionally, DT reduced the expression of the endothelial adhesion molecules E-selectin, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) after activation.	Diterpenes	14-16	intercellular adhesion molecule 1	Mus musculus	137-170
27154204-9	2016	Additionally, DT reduced the expression of the endothelial adhesion molecules E-selectin, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) after activation.	Diterpenes	14-16	intercellular adhesion molecule 1	Mus musculus	172-178
27154204-12	2016	Our findings establish DT as a novel endothelial inhibitor for the treatment of inflammatory-related diseases triggered by Gram-negative bacteria or by the associated cytokine TNF-alpha.	Diterpenes	23-25	tumor necrosis factor	Mus musculus	176-185
27154204-4	2016	Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced.	Diterpenes	40-42	interleukin 10	Mus musculus	268-273
27328029-0	2016	Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.	Diterpenes	11-23	ATP binding cassette subfamily B member 1	Homo sapiens	41-55
27228307-0	2016	Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson"s Disease.	Diterpenes	9-19	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	48-53
26013851-2	2016	Gibberellic acid (GA3 ) is a plant-derived diterpenoid with documented anti-inflammatory activity, which is reported to induce A20-like zinc finger proteins in plants.	Diterpenes	43-54	tumor necrosis factor, alpha-induced protein 3	Mus musculus	127-130
26939786-11	2016	Thus, for the first time, these data highlighted the potential use of the diterpene in the sensitization of GBM cells to chemotherapy through a direct re-activation of p53 pathway.	Diterpenes	74-83	tumor protein p53	Homo sapiens	168-171
26960032-8	2016	This is the first report of serrulatane-type diterpenoids as potential alpha-glucosidase and/or PTP1B inhibitors.	Diterpenes	45-57	sucrase-isomaltase	Homo sapiens	71-88
26960032-8	2016	This is the first report of serrulatane-type diterpenoids as potential alpha-glucosidase and/or PTP1B inhibitors.	Diterpenes	45-57	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	96-101
26704389-3	2016	Oridonin is a diterpenoid isolated from Rabdosia rubescens that can block the NF-kappaB signaling cascades.	Diterpenes	14-25	nuclear factor kappa B subunit 1	Homo sapiens	81-87
26969382-13	2016	Among the active diterpenoids, compound 10, 3alpha-cinnamoyloxy-9ss-hydroxy-ent-kaura-16-en-19-oic acid (CHKA), possessed the strongest effect, and it affected multiple molecular targets related to angiogenesis including VEGF and angiopoietin in Zerbrafish.	Diterpenes	17-29	choline kinase alpha	Mus musculus	105-109
26969382-13	2016	Among the active diterpenoids, compound 10, 3alpha-cinnamoyloxy-9ss-hydroxy-ent-kaura-16-en-19-oic acid (CHKA), possessed the strongest effect, and it affected multiple molecular targets related to angiogenesis including VEGF and angiopoietin in Zerbrafish.	Diterpenes	17-29	vascular endothelial growth factor A	Mus musculus	221-225
26576030-4	2016	These four diterpenoids in plasma samples were extracted by a simple protein precipitation method with methanol and separated on a Kinetex C18 column using a gradient system with a mobile phase of acetonitrile and water.	Diterpenes	11-23	Bardet-Biedl syndrome 9	Homo sapiens	139-142
26757824-2	2016	Through high-throughput chemical screens we have disclosed that pterisolic acid B (J19), a naturally occuring diterpenoid, is an effective Nrf2 activator.	Diterpenes	110-121	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
27222061-1	2016	Tanshinone IIA is a diterpene extracted from Salvia miltiorrhiza, a popular and safe herb medicine that has been widely used in China and other Asian countries.	Diterpenes	20-29	ATPase, class II, type 9A	Mus musculus	11-14
26500253-13	2016	We conclude that larch-derived labdane-type diterpenes are TRPC6-selective inhibitors and may represent a starting point for pharmacological TRPC6 modulation within experimental therapies.	Diterpenes	44-54	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	59-64
26500253-13	2016	We conclude that larch-derived labdane-type diterpenes are TRPC6-selective inhibitors and may represent a starting point for pharmacological TRPC6 modulation within experimental therapies.	Diterpenes	44-54	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	141-146
26821066-0	2016	The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.	Diterpenes	14-23	notch receptor 1	Homo sapiens	134-140
25900047-3	2015	The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.	Diterpenes	13-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-157
26675722-8	2015	Specifically, it affords not only the targeted natural products, but also intermediates and derivatives in the three families of diterpenoid alkaloids (C-18, C-19 and C-20), and so provides a unified synthetic strategy for these natural products.	Diterpenes	129-140	Bardet-Biedl syndrome 9	Homo sapiens	152-156
26061604-0	2015	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	Diterpenes	27-37	ATM serine/threonine kinase	Homo sapiens	103-106
26061604-0	2015	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	Diterpenes	27-37	ATR serine/threonine kinase	Homo sapiens	107-110
26061604-0	2015	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	Diterpenes	27-37	checkpoint kinase 1	Homo sapiens	111-115
26061604-0	2015	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	Diterpenes	27-37	checkpoint kinase 2	Homo sapiens	116-120
26363359-10	2015	To elucidate further the function of DXR in the biosynthesis of diterpenoids, overexpression vectors for NtDXR1 under the control of a trichome-specific CYP promoter were transferred to tobacco plants.	Diterpenes	64-76	1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic	Nicotiana tabacum	37-40
26483054-10	2015	In fungi, these di-TPSs allowed for the formation of clusters consisting in di-TPS, GGPPS and P450 genes to create functional clusters that were transferred between fungal species, producing diterpenes acting as hormones or toxins, thus affecting fungal development and pathogenicity.	Diterpenes	191-201	geranylgeranyl diphosphate synthase 1	Homo sapiens	84-89
26439749-5	2015	These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis.	Diterpenes	18-30	smoothened, frizzled class receptor	Homo sapiens	130-133
26648189-0	2015	Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells.	Diterpenes	39-50	caspase 9	Homo sapiens	14-23
26231349-1	2015	Tanshinone IIA (TSA) is a lipophilic diterpene purified from the Chinese herb Danshen, which exhibits potent antioxidant and anti-inflammatory properties.	Diterpenes	37-46	ATPase, class II, type 9A	Mus musculus	11-14
26186544-2	2015	In the present study, several diterpenoids were examined for ability to induce XBP1 splicing and/or lipotoxicity for human hepatoma cell lines.	Diterpenes	30-42	X-box binding protein 1	Homo sapiens	79-83
25528328-0	2015	Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway.	Diterpenes	26-38	mitogen-activated protein kinase 1	Homo sapiens	96-99
26253170-0	2015	A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells.	Diterpenes	13-22	voltage-dependent anion channel 1	Mus musculus	31-36
26253170-0	2015	A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells.	Diterpenes	13-22	BCL2-associated X protein	Mus musculus	60-63
26186245-0	2015	Diterpenoids from aerial parts of Flickingeria fimbriata and their nuclear factor-kappaB inhibitory activities.	Diterpenes	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-88
26091146-0	2015	hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala.	Diterpenes	33-44	ETS transcription factor ERG	Homo sapiens	0-4
26244825-0	2015	Six new cassane diterpenes from the twigs and leaves of Tara (Caesalpinia spinosa Kuntze).	Diterpenes	16-26	TRIO and F-actin binding protein	Homo sapiens	56-60
26186544-3	2015	Here we show that three groups of diterpenoids emerged: 1) GGA, 2,3-dihydro GGA and 9-cis retinoic acid induce cell death and XBP1 splicing; 2) all-trans retinoic acid induces XBP1 splicing but little cell death; and 3) phytanic acid, phytenic acid and geranylgeraniol induce neither cell death nor XBP1 splicing.	Diterpenes	34-46	X-box binding protein 1	Homo sapiens	126-130
26186544-3	2015	Here we show that three groups of diterpenoids emerged: 1) GGA, 2,3-dihydro GGA and 9-cis retinoic acid induce cell death and XBP1 splicing; 2) all-trans retinoic acid induces XBP1 splicing but little cell death; and 3) phytanic acid, phytenic acid and geranylgeraniol induce neither cell death nor XBP1 splicing.	Diterpenes	34-46	X-box binding protein 1	Homo sapiens	176-180
26186544-3	2015	Here we show that three groups of diterpenoids emerged: 1) GGA, 2,3-dihydro GGA and 9-cis retinoic acid induce cell death and XBP1 splicing; 2) all-trans retinoic acid induces XBP1 splicing but little cell death; and 3) phytanic acid, phytenic acid and geranylgeraniol induce neither cell death nor XBP1 splicing.	Diterpenes	34-46	X-box binding protein 1	Homo sapiens	176-180
25786135-4	2015	Co-expression in E. coli of CPT2 and TPS21 led to the formation of the diterpene lycosantalene, and co-expression in E. coli of CPT2, TPS21 and CYP71BN1 led to the formation of lycosantalonol, an oxidation product of lycosantalene.	Diterpenes	71-80	dimethylallylcistransferase, chloroplastic-like	Solanum lycopersicum	28-32
25786135-9	2015	The involvement of CPT2, TPS21 and CYP71BN1 in a diterpenoid biosynthetic pathway outside the trichomes, together with the involvement of other genes in the cluster in the synthesis of monoterpenes in trichomes, indicates that this cluster is further evolving into "sub-clusters" with unique biochemical, and likely physiological, roles.	Diterpenes	49-60	dimethylallylcistransferase, chloroplastic-like	Solanum lycopersicum	19-23
25721973-0	2015	Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells.	Diterpenes	28-37	signal transducer and activator of transcription 3	Homo sapiens	47-52
25644525-1	2015	Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes.	Diterpenes	162-172	neuraminidase 1	Homo sapiens	37-50
25644525-1	2015	Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes.	Diterpenes	162-172	neuraminidase 1	Homo sapiens	52-54
25644525-1	2015	Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes.	Diterpenes	222-232	neuraminidase 1	Homo sapiens	52-54
25644525-5	2015	Anti-NA activities of the isolated diterpenes were evaluated.	Diterpenes	35-45	neuraminidase 1	Homo sapiens	5-7
25786135-9	2015	The involvement of CPT2, TPS21 and CYP71BN1 in a diterpenoid biosynthetic pathway outside the trichomes, together with the involvement of other genes in the cluster in the synthesis of monoterpenes in trichomes, indicates that this cluster is further evolving into "sub-clusters" with unique biochemical, and likely physiological, roles.	Diterpenes	49-60	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic-like	Solanum lycopersicum	25-30
25786135-4	2015	Co-expression in E. coli of CPT2 and TPS21 led to the formation of the diterpene lycosantalene, and co-expression in E. coli of CPT2, TPS21 and CYP71BN1 led to the formation of lycosantalonol, an oxidation product of lycosantalene.	Diterpenes	71-80	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic-like	Solanum lycopersicum	37-42
25786135-9	2015	The involvement of CPT2, TPS21 and CYP71BN1 in a diterpenoid biosynthetic pathway outside the trichomes, together with the involvement of other genes in the cluster in the synthesis of monoterpenes in trichomes, indicates that this cluster is further evolving into "sub-clusters" with unique biochemical, and likely physiological, roles.	Diterpenes	49-60	premnaspirodiene oxygenase	Solanum lycopersicum	35-43
25786135-4	2015	Co-expression in E. coli of CPT2 and TPS21 led to the formation of the diterpene lycosantalene, and co-expression in E. coli of CPT2, TPS21 and CYP71BN1 led to the formation of lycosantalonol, an oxidation product of lycosantalene.	Diterpenes	71-80	premnaspirodiene oxygenase	Solanum lycopersicum	144-152
26235164-1	2015	This review summarizes the efforts to develop a radical-mediated three-component reaction and its application to a convergent approach to synthesize the 5/7/6-tricyclic framework (ABC-rings) of the densely functionalized dephnane diterpene, resiniferatoxin.	Diterpenes	230-239	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	180-183
25557296-0	2015	A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: involvement of AKT-dependent mechanisms.	Diterpenes	10-19	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
25410799-8	2015	Docking studies were carried out which revealed that both the diterpenes interacted within the active site of N-terminal and C-terminal domain of human maltase-glucoamylase enzyme, respectively.	Diterpenes	62-72	maltase-glucoamylase	Homo sapiens	152-172
25304375-3	2015	Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in the traditional Chinese medicine Danshen (Salvia sp.).	Diterpenes	30-41	ATPase, class II, type 9A	Mus musculus	11-14
25304375-3	2015	Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in the traditional Chinese medicine Danshen (Salvia sp.).	Diterpenes	30-41	ATPase, class II, type 9A	Mus musculus	20-23
26494928-1	2015	Bioassay-guided fractionation of the Caribbean sponge Svenzea flava collected near Mona Island, off the west coast of Puerto Rico, led to the isolation of two isocyanide amphilectane-type diterpenes named monamphilectines B and C (2 and 3).	Diterpenes	188-198	GRB2 related adaptor protein 2	Homo sapiens	83-87
25450865-6	2015	Diterpene compound 1 during early differentiation reduced MDI induced-Akt/mTOR phosphorylation and expression of cell cycle proteins, and thereby halted mitotic clonal expansion, the decisive factor in early adipogenesis.	Diterpenes	0-9	thymoma viral proto-oncogene 1	Mus musculus	70-73
25450865-6	2015	Diterpene compound 1 during early differentiation reduced MDI induced-Akt/mTOR phosphorylation and expression of cell cycle proteins, and thereby halted mitotic clonal expansion, the decisive factor in early adipogenesis.	Diterpenes	0-9	mechanistic target of rapamycin kinase	Mus musculus	74-78
26181334-0	2015	Inhibition of human neutrophil elastase by labdane diterpenes from the fruiting bodies of Ramaria formosa.	Diterpenes	51-61	elastase, neutrophil expressed	Homo sapiens	20-39
25600769-0	2015	A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/beta-catenin signaling.	Diterpenes	20-31	catenin beta 1	Homo sapiens	105-117
25371982-5	2014	The MDR reversal potential of macrocyclic diterpenes 3-5 was evaluated through a drug combination assay, using the L5178Y mouse T lymphoma cell line transfected with the human MDR1 gene.	Diterpenes	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	176-180
25447154-5	2015	A large number of targets of diterpenes have been identified in cancer cells including NF-kappaB, STAT3, Bcl-xL, beta-catenin, cytochrome C and caspases.	Diterpenes	29-39	nuclear factor kappa B subunit 1	Homo sapiens	87-96
25447154-5	2015	A large number of targets of diterpenes have been identified in cancer cells including NF-kappaB, STAT3, Bcl-xL, beta-catenin, cytochrome C and caspases.	Diterpenes	29-39	signal transducer and activator of transcription 3	Homo sapiens	98-103
25447154-5	2015	A large number of targets of diterpenes have been identified in cancer cells including NF-kappaB, STAT3, Bcl-xL, beta-catenin, cytochrome C and caspases.	Diterpenes	29-39	BCL2 like 1	Homo sapiens	105-111
25447154-5	2015	A large number of targets of diterpenes have been identified in cancer cells including NF-kappaB, STAT3, Bcl-xL, beta-catenin, cytochrome C and caspases.	Diterpenes	29-39	catenin beta 1	Homo sapiens	113-125
25925366-10	2015	We demonstrate that the experimental use of naturally occurring plant diterpenes such as gibberellin on lipopolysaccharide-stimulated cell lines reduces IL-8 release in an A20-dependent manner.	Diterpenes	70-80	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
25925366-10	2015	We demonstrate that the experimental use of naturally occurring plant diterpenes such as gibberellin on lipopolysaccharide-stimulated cell lines reduces IL-8 release in an A20-dependent manner.	Diterpenes	70-80	TNF alpha induced protein 3	Homo sapiens	172-175
25446975-0	2015	Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase.	Diterpenes	10-19	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	55-61
25446975-4	2015	In this report, we identify the modular structure of geranylgeranyl diphosphate synthesis in yeast to be a major limitation in diterpene yields, and we engineer the yeast farnesyl diphosphate synthase Erg20p to produce geranylgeranyl diphosphate.	Diterpenes	127-136	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	201-207
25446975-6	2015	We also report the development of yeast strains carrying the engineered Erg20p, which support efficient isoprenoid production and can be used as a dedicated chassis for diterpene production or biosynthetic pathway elucidation.	Diterpenes	169-178	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	72-78
25047443-0	2014	Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells.	Diterpenes	14-23	TNF superfamily member 11	Homo sapiens	65-70
25438763-1	2014	Aiming to optimize macrocyclic lathyrane-type diterpenes as effective Pgp modulators, the phytochemical study of the methanolic extract of Euphorbia boetica aerial parts was carried out.	Diterpenes	46-56	phosphoglycolate phosphatase	Homo sapiens	70-73
24927992-0	2014	High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells.	Diterpenes	44-55	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	83-86
25918783-4	2014	This study investigated the cytotoxic activity of the diterpene AEP-1, extracted from the fruit of E. passerinum in a GL-15 cell line, astrocytic, glial cells model.	Diterpenes	54-63	SPATA31 subfamily A member 7	Homo sapiens	64-69
25172144-5	2014	CYP726A14, CYP726A17, and CYP726A18 were able to catalyze 5-oxidation of casbene, a conserved oxidation step in the biosynthesis of this family of medicinally important diterpenoids.	Diterpenes	169-181	premnaspirodiene oxygenase	Ricinus communis	0-9
25065531-0	2014	Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110gamma/delta subunits and inhibition of NF-kappaB.	Diterpenes	52-62	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	94-103
25065531-2	2014	Some pimarane diterpenes are known activators of the LXRalphabeta nuclear receptors, but we show here that they also exert a rapid, potent, and selective activation of the p110gamma and p110delta subunits of PI3K.	Diterpenes	14-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	172-181
25065531-2	2014	Some pimarane diterpenes are known activators of the LXRalphabeta nuclear receptors, but we show here that they also exert a rapid, potent, and selective activation of the p110gamma and p110delta subunits of PI3K.	Diterpenes	14-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Mus musculus	186-195
25065531-6	2014	Silencing or inhibition of p110gamma/delta suppressed the effect of these diterpenes (DTPs) on IKK/NF-kappaB and MAPKs signaling.	Diterpenes	74-84	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	27-36
25065531-6	2014	Silencing or inhibition of p110gamma/delta suppressed the effect of these diterpenes (DTPs) on IKK/NF-kappaB and MAPKs signaling.	Diterpenes	86-90	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	27-36
25017625-5	2014	Taking into account that 1 showed moderate inhibition of AChE (IC50=21.1 muM), selectivity over butyrylcholinesterase (BChE) (IC50=171.1 muM) and that it was easily obtained from the plant extract in a very good yield (0.15% w/w), we decided to prepare semisynthetic derivatives of this natural diterpenoid through simple structural modifications.	Diterpenes	295-306	butyrylcholinesterase	Homo sapiens	119-123
25172144-5	2014	CYP726A14, CYP726A17, and CYP726A18 were able to catalyze 5-oxidation of casbene, a conserved oxidation step in the biosynthesis of this family of medicinally important diterpenoids.	Diterpenes	169-181	premnaspirodiene oxygenase	Ricinus communis	11-20
25172144-5	2014	CYP726A14, CYP726A17, and CYP726A18 were able to catalyze 5-oxidation of casbene, a conserved oxidation step in the biosynthesis of this family of medicinally important diterpenoids.	Diterpenes	169-181	premnaspirodiene oxygenase	Ricinus communis	26-35
24992702-6	2014	Norditerpene 2 modestly inhibited aromatase with an IC50 of 34 muM and induced quinone reductase 1 activity with a CD (the concentration needed to double the enzymatic response) of 11.2 muM.	Diterpenes	0-12	latexin	Homo sapiens	63-66
24992702-6	2014	Norditerpene 2 modestly inhibited aromatase with an IC50 of 34 muM and induced quinone reductase 1 activity with a CD (the concentration needed to double the enzymatic response) of 11.2 muM.	Diterpenes	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	79-98
24999828-4	2014	A homology model of hTAS2R31 was constructed, and the molecular docking of 2 to this model indicated that this diterpenoid binds well to the active site of hTAS2R31, whereas this was not the case for the closely structurally related compound 3 (sempervirenic acid).	Diterpenes	111-122	taste 2 receptor member 31	Homo sapiens	156-164
24992702-6	2014	Norditerpene 2 modestly inhibited aromatase with an IC50 of 34 muM and induced quinone reductase 1 activity with a CD (the concentration needed to double the enzymatic response) of 11.2 muM.	Diterpenes	0-12	latexin	Homo sapiens	186-189
24999828-3	2014	Among these compounds, 3beta-acetoxycopalic acid (2) was found to be the first member of the labdane diterpene class shown to have inhibitory activity against hTAS2R31 activation (IC50 8 muM).	Diterpenes	101-110	taste 2 receptor member 31	Homo sapiens	159-167
24999828-4	2014	A homology model of hTAS2R31 was constructed, and the molecular docking of 2 to this model indicated that this diterpenoid binds well to the active site of hTAS2R31, whereas this was not the case for the closely structurally related compound 3 (sempervirenic acid).	Diterpenes	111-122	taste 2 receptor member 31	Homo sapiens	20-28
25035868-8	2014	Furthermore, some diterpenoid compounds, which restore the growth of rsp5(A401E) cells, showed the activities of calcineurin inhibition and protein phosphatase 2C activation.	Diterpenes	18-29	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	69-73
24840014-0	2014	Ingol-type diterpenes from Euphorbia antiquorum with mouse 11beta-hydroxysteroid dehydrogenase type 1 inhibition activity.	Diterpenes	11-21	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	59-101
24840014-3	2014	Diterpenes 1, 14, and 22 exhibited inhibitory activities against mouse 11beta-HSD1 with IC50 values of 12.0, 6.4, and 0.41 muM, respectively.	Diterpenes	0-10	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	71-82
24927548-9	2014	The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiinfective drug leads.	Diterpenes	53-65	farnesyl diphosphate synthase	Homo sapiens	36-40
24927548-9	2014	The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiinfective drug leads.	Diterpenes	53-65	intracisternal A particle-promoted polypeptide	Homo sapiens	105-108
24799257-5	2014	These three natural RAR agonists with diterpene structures, while structurally different from ATRA, were able to increase the mRNA levels of the constitutive androstane receptor in HepG2 cells, induce F9 cell differentiation followed by Cyp26a1 mRNA expression, and differentiate HL-60 cells via RAR activation in a different manner from ATRA.	Diterpenes	38-47	retinoic acid receptor alpha	Homo sapiens	20-23
24799257-5	2014	These three natural RAR agonists with diterpene structures, while structurally different from ATRA, were able to increase the mRNA levels of the constitutive androstane receptor in HepG2 cells, induce F9 cell differentiation followed by Cyp26a1 mRNA expression, and differentiate HL-60 cells via RAR activation in a different manner from ATRA.	Diterpenes	38-47	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	237-244
24799257-5	2014	These three natural RAR agonists with diterpene structures, while structurally different from ATRA, were able to increase the mRNA levels of the constitutive androstane receptor in HepG2 cells, induce F9 cell differentiation followed by Cyp26a1 mRNA expression, and differentiate HL-60 cells via RAR activation in a different manner from ATRA.	Diterpenes	38-47	retinoic acid receptor alpha	Homo sapiens	296-299
24799257-6	2014	These results demonstrate that some diterpenes exist as naturally occurring RAR agonists and that the differences in chemical structure between ATRA and these diterpenes may induce distinct gene activation and a specific cellular response.	Diterpenes	36-46	retinoic acid receptor alpha	Homo sapiens	76-79
24799257-6	2014	These results demonstrate that some diterpenes exist as naturally occurring RAR agonists and that the differences in chemical structure between ATRA and these diterpenes may induce distinct gene activation and a specific cellular response.	Diterpenes	159-169	retinoic acid receptor alpha	Homo sapiens	76-79
24709561-4	2014	Podocarpane diterpenes, crossogumerin B (2) and nimbiol (10), exhibited the highest activity against HeLa cells (IC50 values of 3.1 and 8.1 muM, respectively), but also selectivity on Vero cells (SI 22.6 and 7.5, respectively).	Diterpenes	12-22	latexin	Homo sapiens	140-143
24723453-0	2014	Coleusin factor, a novel anticancer diterpenoid, inhibits osteosarcoma growth by inducing bone morphogenetic protein-2-dependent differentiation.	Diterpenes	36-47	bone morphogenetic protein 2	Mus musculus	90-118
24476312-0	2014	ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.	Diterpenes	12-24	mitogen-activated protein kinase 8	Homo sapiens	124-127
24513856-3	2014	Here, we identified a diterpenoid derivative 15-oxospiramilactone (S3) that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2.	Diterpenes	22-33	mitofusin 1	Homo sapiens	215-219
24513856-3	2014	Here, we identified a diterpenoid derivative 15-oxospiramilactone (S3) that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2.	Diterpenes	22-33	mitofusin 2	Homo sapiens	223-227
24406160-0	2014	Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives.	Diterpenes	59-70	lysine demethylase 1A	Homo sapiens	14-43
24476312-0	2014	ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.	Diterpenes	12-24	mitogen-activated protein kinase 8	Homo sapiens	185-188
24476312-0	2014	ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.	Diterpenes	12-24	mitogen-activated protein kinase kinase 4	Homo sapiens	196-200
23972040-0	2014	New briarane-type diterpenoids from gorgonian Ellisella dollfusi from the South China Sea.	Diterpenes	18-30	dynein axonemal assembly factor 11	Danio rerio	86-89
24044886-0	2013	A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin beta1/FAK/PI3K/AKT/beta-catenin signaling.	Diterpenes	2-13	integrin subunit beta 1	Homo sapiens	109-123
24386454-3	2013	Here we report the antiplatelet effect of glaucocalyxin A (GLA), an ent-diterpenoid that we isolated and purified from the aerial parts of Rabdosia japonica (Burm.	Diterpenes	72-83	galactosidase, alpha	Mus musculus	59-62
24358331-0	2013	A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages.	Diterpenes	16-25	tumor necrosis factor	Mus musculus	143-152
24358331-3	2013	In this study we investigated the anti-inflammatory effects of a known pseudopterane diterpene (referred here as compound 1) isolated from the octocoral Pseudopterogorgia acerosa on the tumor necrosis factor- alpha (TNF-alpha) and TLRs- induced response in macrophages.	Diterpenes	85-94	tumor necrosis factor	Mus musculus	216-225
24001712-4	2013	Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 muM, 42.4 muM and 39.4 muM, respectively.	Diterpenes	14-24	latexin	Homo sapiens	222-225
24001712-4	2013	Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 muM, 42.4 muM and 39.4 muM, respectively.	Diterpenes	14-24	latexin	Homo sapiens	232-235
24001712-4	2013	Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 muM, 42.4 muM and 39.4 muM, respectively.	Diterpenes	14-24	latexin	Homo sapiens	232-235
24044886-0	2013	A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin beta1/FAK/PI3K/AKT/beta-catenin signaling.	Diterpenes	2-13	protein tyrosine kinase 2	Homo sapiens	124-127
24044886-0	2013	A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin beta1/FAK/PI3K/AKT/beta-catenin signaling.	Diterpenes	2-13	AKT serine/threonine kinase 1	Homo sapiens	133-136
24044886-0	2013	A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin beta1/FAK/PI3K/AKT/beta-catenin signaling.	Diterpenes	2-13	catenin beta 1	Homo sapiens	137-149
24033131-2	2013	Compounds 1 and 2 are the first examples of clerodane diterpenoids with an oxygen bridge between C-2 and C-19, and compounds 5-7 are three new diterpenoid artifacts presumably formed during the extraction process.	Diterpenes	54-66	complement C2	Homo sapiens	97-100
23732520-0	2013	A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.	Diterpenes	2-13	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96
23732520-0	2013	A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.	Diterpenes	2-13	BCL2 antagonist/killer 1	Homo sapiens	97-100
23732520-1	2013	We have previously shown that the natural diterpenoid derivative S3 induced Bim upregulation and apoptosis in a Bax/Bak-independent manner.	Diterpenes	42-53	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
23732520-1	2013	We have previously shown that the natural diterpenoid derivative S3 induced Bim upregulation and apoptosis in a Bax/Bak-independent manner.	Diterpenes	42-53	BCL2 antagonist/killer 1	Homo sapiens	116-119
24033131-2	2013	Compounds 1 and 2 are the first examples of clerodane diterpenoids with an oxygen bridge between C-2 and C-19, and compounds 5-7 are three new diterpenoid artifacts presumably formed during the extraction process.	Diterpenes	54-65	complement C2	Homo sapiens	97-100
23648389-7	2013	Thus, DA1 is a novel neuroprotective pro-electrophilic diterpene from green plant.	Diterpenes	55-64	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	6-9
23859780-0	2013	Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.	Diterpenes	9-21	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	100-105
23859780-4	2013	This is the first report on the anti-PTP1B activity of cembrane diterpenoids.	Diterpenes	64-76	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	37-42
23548583-0	2013	Nrf2-dependent neuroprotective activity of diterpenoids isolated from Sideritis spp.	Diterpenes	43-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
23747808-0	2013	Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11beta-HSD1 inhibitors: potential impact in diabetes.	Diterpenes	62-74	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	99-110
23747808-1	2013	The biological screening of a collection of nature occurring diterpenoids against 11beta-HSD1 resulted in the discovery of the lead compound 1b, which pointed to the therapeutic potential for type 2 diabetes.	Diterpenes	61-73	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	82-93
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	cytochrome c, somatic	Homo sapiens	129-141
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	diablo IAP-binding mitochondrial protein	Homo sapiens	143-147
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	diablo IAP-binding mitochondrial protein	Homo sapiens	148-154
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	apoptosis inducing factor mitochondria associated 1	Homo sapiens	160-163
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	apoptosis inducing factor mitochondria associated 1	Homo sapiens	165-190
23865778-6	2013	Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (DeltaPsi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.	Diterpenes	37-47	mitogen-activated protein kinase 14	Homo sapiens	360-363
23548583-10	2013	The Nrf2 pathway was involved, at least in part, in the protective effects of these diterpenoids.	Diterpenes	84-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
23757397-2	2013	Here, we show that a cluster of genes in tomato (Solanum lycopersicum; Solanaceae) contains genes for terpene synthases (TPSs) that specify the synthesis of monoterpenes and diterpenes from cis-prenyl diphosphates, substrates that are synthesized by enzymes encoded by cis-prenyl transferase (CPT) genes also located within the same cluster.	Diterpenes	174-184	dehydrodolichyl diphosphate synthase 2	Solanum lycopersicum	269-291
23757397-2	2013	Here, we show that a cluster of genes in tomato (Solanum lycopersicum; Solanaceae) contains genes for terpene synthases (TPSs) that specify the synthesis of monoterpenes and diterpenes from cis-prenyl diphosphates, substrates that are synthesized by enzymes encoded by cis-prenyl transferase (CPT) genes also located within the same cluster.	Diterpenes	174-184	dehydrodolichyl diphosphate synthase 2	Solanum lycopersicum	293-296
23564360-0	2013	NtPDR1, a plasma membrane ABC transporter from Nicotiana tabacum, is involved in diterpene transport.	Diterpenes	81-90	pleiotropic drug resistance protein 1	Nicotiana tabacum	0-6
23980366-0	2013	[Effects of diterpene phenol extract of Rosmarinus officinalis on TGFbeta1 and mRNA expressions of its signaling pathway molecules in the lung tissue of pulmonary fibrosis rats].	Diterpenes	12-21	transforming growth factor, beta 1	Rattus norvegicus	66-74
23443807-0	2013	Spongian diterpenoids inhibit androgen receptor activity.	Diterpenes	9-21	androgen receptor	Homo sapiens	30-47
23443807-4	2013	Characterization of T1 and the structurally related semisynthetic analogues (T2 and T3) revealed that these diterpenoids have antiandrogen properties that include inhibition of both androgen-dependent proliferation and androgen receptor transcriptional activity by a mechanism that involved competing with androgen for androgen receptor LBD and blocking essential N/C interactions required for androgen-induced androgen receptor transcriptional activity.	Diterpenes	108-120	androgen receptor	Homo sapiens	219-236
23443807-4	2013	Characterization of T1 and the structurally related semisynthetic analogues (T2 and T3) revealed that these diterpenoids have antiandrogen properties that include inhibition of both androgen-dependent proliferation and androgen receptor transcriptional activity by a mechanism that involved competing with androgen for androgen receptor LBD and blocking essential N/C interactions required for androgen-induced androgen receptor transcriptional activity.	Diterpenes	108-120	androgen receptor	Homo sapiens	319-336
23443807-4	2013	Characterization of T1 and the structurally related semisynthetic analogues (T2 and T3) revealed that these diterpenoids have antiandrogen properties that include inhibition of both androgen-dependent proliferation and androgen receptor transcriptional activity by a mechanism that involved competing with androgen for androgen receptor LBD and blocking essential N/C interactions required for androgen-induced androgen receptor transcriptional activity.	Diterpenes	108-120	androgen receptor	Homo sapiens	319-336
23443807-7	2013	The ability to create analogues of diterpenoids that have varying antiandrogen activity represents a novel class of chemical compounds for the analysis of androgen receptor ligand-binding properties and therapeutic development.	Diterpenes	35-47	androgen receptor	Homo sapiens	155-172
23564360-9	2013	Constitutive ectopic expression of NtPDR1 in N. tabacum BY2 cells resulted in increased resistance to several diterpenes.	Diterpenes	110-120	pleiotropic drug resistance protein 1	Nicotiana tabacum	35-41
23564360-10	2013	Transport tests directly demonstrated the ability of NtPDR1 to transport diterpenes.	Diterpenes	73-83	pleiotropic drug resistance protein 1	Nicotiana tabacum	53-59
23564360-11	2013	These data suggest that NtPDR1 is involved in plant defense through diterpene transport.	Diterpenes	68-77	pleiotropic drug resistance protein 1	Nicotiana tabacum	24-30
23228414-0	2013	QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity.	Diterpenes	28-38	ATP binding cassette subfamily B member 1	Homo sapiens	44-58
23609581-4	2013	The results revealed that cembrane-type diterpenoids, especially lobocrassin B, effectively inhibited LPS-induced BMDC activation by inhibiting the production of TNF-alpha.	Diterpenes	40-52	tumor necrosis factor	Mus musculus	162-171
23459302-3	2013	This diterpenoid led to caspases -3, -8, and -9 activation as well as PARP cleavage.	Diterpenes	5-16	caspase 3	Homo sapiens	24-47
23459302-3	2013	This diterpenoid led to caspases -3, -8, and -9 activation as well as PARP cleavage.	Diterpenes	5-16	poly(ADP-ribose) polymerase 1	Homo sapiens	70-74
23512856-0	2013	Formation of the unusual semivolatile diterpene rhizathalene by the Arabidopsis class I terpene synthase TPS08 in the root stele is involved in defense against belowground herbivory.	Diterpenes	38-47	Terpenoid cyclases/Protein prenyltransferases superfamily protein	Arabidopsis thaliana	105-110
23512856-6	2013	TPS08 expression is largely localized to the root stele, suggesting a centric and gradual release of its diterpene products into the peripheral root cell layers.	Diterpenes	105-114	Terpenoid cyclases/Protein prenyltransferases superfamily protein	Arabidopsis thaliana	0-5
23416714-16	2013	We identified the molecular chaperone HSP70 1A as an oridonin target in Jurkat cells, thus suggesting a mechanism of action for the diterpene consistent with the multiple biological activities described for it.	Diterpenes	132-141	heat shock protein family A (Hsp70) member 1A	Homo sapiens	38-46
23228414-5	2013	In this study we applied quantitative structure-activity relationship (QSAR) methodology in order to identify the most relevant molecular features of macrocyclic diterpenes with P-gp inhibitory activity and to determine which structural modifications can be performed to improve their activity.	Diterpenes	162-172	ATP binding cassette subfamily B member 1	Homo sapiens	178-182
23336337-4	2013	In this small library of novel bioactive macrocyclic lathyrane diterpene derivatives, designed to evaluate structure-activity relationships essential in overcoming multidrug resistance (MDR), some correlations between MDR reversal and molecular weight, accessible solvent areas, and octanol/water partition coefficient were identified that can contribute to the development of new selective P-gp reversal agents.	Diterpenes	63-72	phosphoglycolate phosphatase	Homo sapiens	391-395
23079631-0	2013	Involvement of Nrf2 signaling pathway in the neuroprotective activity of natural kaurane diterpenes.	Diterpenes	89-99	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
23079631-8	2013	Furthermore, these natural products increased Nrf2 nuclear levels, suggesting the activation of this master regulator of antioxidative gene expressions in the protective effect exhibited by the kaurane diterpenes studied.	Diterpenes	202-212	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
22310289-3	2013	Here, we report that hispanolone derivatives, a group of labdane diterpenoids, induce apoptosis in different tumor cell lines by activating caspase-8 with subsequent participation of mitochondrial signaling.	Diterpenes	65-77	caspase 8	Homo sapiens	140-149
22310289-7	2013	In addition, silencing death receptors with small interfering RNA s or pretreating cells with neutralizing antibodies to Fas ligand, tumor necrosis factor receptor 1 (TNF-R1), and TNF-alpha receptor 2 (TRAIL) inhibited diterpenoid-induced apoptosis, revealing it to be dependent on these death receptors.	Diterpenes	219-230	Fas ligand	Homo sapiens	121-131
22310289-7	2013	In addition, silencing death receptors with small interfering RNA s or pretreating cells with neutralizing antibodies to Fas ligand, tumor necrosis factor receptor 1 (TNF-R1), and TNF-alpha receptor 2 (TRAIL) inhibited diterpenoid-induced apoptosis, revealing it to be dependent on these death receptors.	Diterpenes	219-230	TNF receptor superfamily member 1A	Homo sapiens	133-165
22310289-7	2013	In addition, silencing death receptors with small interfering RNA s or pretreating cells with neutralizing antibodies to Fas ligand, tumor necrosis factor receptor 1 (TNF-R1), and TNF-alpha receptor 2 (TRAIL) inhibited diterpenoid-induced apoptosis, revealing it to be dependent on these death receptors.	Diterpenes	219-230	TNF receptor superfamily member 1A	Homo sapiens	167-173
22310289-7	2013	In addition, silencing death receptors with small interfering RNA s or pretreating cells with neutralizing antibodies to Fas ligand, tumor necrosis factor receptor 1 (TNF-R1), and TNF-alpha receptor 2 (TRAIL) inhibited diterpenoid-induced apoptosis, revealing it to be dependent on these death receptors.	Diterpenes	219-230	TNF superfamily member 10	Homo sapiens	202-207
23302650-0	2013	An ent-kaurane diterpenoid from Croton tonkinensis induces apoptosis by regulating AMP-activated protein kinase in SK-HEP1 human hepatocellular carcinoma cells.	Diterpenes	15-26	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	83-111
23302650-6	2013	In this study, we determined whether the ent-kaurane diterpenoid ent-18-acetoxy-7beta-hydroxy kaur-15-oxo-16-ene (CrT1) isolated from this plant plays a role as a chemotherapeutic drug targeting AMPK.	Diterpenes	53-64	hyaluronan and proteoglycan link protein 1	Homo sapiens	114-118
23302650-6	2013	In this study, we determined whether the ent-kaurane diterpenoid ent-18-acetoxy-7beta-hydroxy kaur-15-oxo-16-ene (CrT1) isolated from this plant plays a role as a chemotherapeutic drug targeting AMPK.	Diterpenes	53-64	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	195-199
23129237-2	2013	In this             study, we found that JB, a diterpenoid from the traditional Chinese medicinal             herb, strongly inhibited the PI3K/Akt/mTOR signaling pathway.	Diterpenes	47-58	AKT serine/threonine kinase 1	Homo sapiens	144-147
24211635-7	2013	Paspaline (6) and emindole SB (7), both lacking BK channel inhibition and tremorgenicity, represent the simplest indole diterpene skeleton that retains the antiproliferative, antimigratory and total beta-catenin suppressing effects shown by the more complex penitrem A (1).	Diterpenes	120-129	catenin beta 1	Homo sapiens	199-211
24096646-0	2013	Diterpene para-hydroquinone compounds derived from cryptoquinone inhibit adipocyte differentiation of mouse 3T3-L1 cells and activate the Nrf2/ARE pathway.	Diterpenes	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
23129237-2	2013	In this             study, we found that JB, a diterpenoid from the traditional Chinese medicinal             herb, strongly inhibited the PI3K/Akt/mTOR signaling pathway.	Diterpenes	47-58	mechanistic target of rapamycin kinase	Homo sapiens	148-152
23141910-1	2012	In the course of ongoing research on protein tyrosine phosphatase 1B (PTP1B) inhibitory compounds from Antarctic lichens, four new diterpene furanoids, hueafuranoids A-D (1-4) have been isolated from the MeOH extract of Antarctic lichen Huea sp.	Diterpenes	131-140	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	37-68
23141910-1	2012	In the course of ongoing research on protein tyrosine phosphatase 1B (PTP1B) inhibitory compounds from Antarctic lichens, four new diterpene furanoids, hueafuranoids A-D (1-4) have been isolated from the MeOH extract of Antarctic lichen Huea sp.	Diterpenes	131-140	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	70-75
23141910-5	2012	The kinetic analysis of PTP1B inhibition by hueafuranoid A (1) suggested that the diterpene furanoids encountered in this study inhibited PTP1B activity in a non-competitive manner.	Diterpenes	82-91	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	24-29
23141910-5	2012	The kinetic analysis of PTP1B inhibition by hueafuranoid A (1) suggested that the diterpene furanoids encountered in this study inhibited PTP1B activity in a non-competitive manner.	Diterpenes	82-91	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	138-143
23098168-0	2012	Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.	Diterpenes	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	69-83
23098168-4	2012	Jatrophane diterpenes 1-3 and 5 were evaluated for their effects on the reversion of multidrug resistance (MDR) mediated by P-glycoprotein, by using the rhodamine-123 exclusion test, on human MDR1 gene-transfected mouse lymphoma cells (L5178Y MDR) and on human colon adenocarcinoma cells (COLO 320).	Diterpenes	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
24009843-0	2012	Anticancer Activity of Novel Daphnane Diterpenoids from Daphne genkwa through Cell-Cycle Arrest and Suppression of Akt/STAT/Src Signalings in Human Lung Cancer Cells.	Diterpenes	38-50	AKT serine/threonine kinase 1	Homo sapiens	115-118
24009843-0	2012	Anticancer Activity of Novel Daphnane Diterpenoids from Daphne genkwa through Cell-Cycle Arrest and Suppression of Akt/STAT/Src Signalings in Human Lung Cancer Cells.	Diterpenes	38-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-127
24009843-7	2012	In the analysis of signal transduction molecules, the daphnane diterpenoids suppressed the activation of Akt, STAT3 and Src in human lung cancer cells.	Diterpenes	63-75	AKT serine/threonine kinase 1	Homo sapiens	105-108
24009843-7	2012	In the analysis of signal transduction molecules, the daphnane diterpenoids suppressed the activation of Akt, STAT3 and Src in human lung cancer cells.	Diterpenes	63-75	signal transducer and activator of transcription 3	Homo sapiens	110-115
24009843-7	2012	In the analysis of signal transduction molecules, the daphnane diterpenoids suppressed the activation of Akt, STAT3 and Src in human lung cancer cells.	Diterpenes	63-75	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	120-123
23046382-0	2012	Diterpenoids isolated from Sideritis species protect astrocytes against oxidative stress via Nrf2.	Diterpenes	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
21963808-0	2011	Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.	Diterpenes	31-42	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	100-106
22922340-0	2012	Lobolide, a diterpene, blockades the NF-kappaB pathway and p38 and ERK MAPK activity in macrophages in vitro.	Diterpenes	12-21	nuclear factor kappa B subunit 1	Homo sapiens	37-46
22922340-0	2012	Lobolide, a diterpene, blockades the NF-kappaB pathway and p38 and ERK MAPK activity in macrophages in vitro.	Diterpenes	12-21	mitogen-activated protein kinase 14	Homo sapiens	59-62
22922340-0	2012	Lobolide, a diterpene, blockades the NF-kappaB pathway and p38 and ERK MAPK activity in macrophages in vitro.	Diterpenes	12-21	mitogen-activated protein kinase 1	Homo sapiens	67-70
22922340-2	2012	The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-kappaB signaling pathway.	Diterpenes	63-72	nuclear factor kappa B subunit 1	Homo sapiens	108-117
23054711-0	2012	Ingenane-type diterpenes with a modulatory effect on IFN-gamma production from the roots of Euphorbia kansui.	Diterpenes	14-24	interferon gamma	Homo sapiens	53-62
22816286-0	2012	A novel isopimarane diterpenoid with acetylcholinesterase inhibitory activity from Nepeta sorgerae, an endemic species to the Nemrut Mountain.	Diterpenes	20-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
22197145-2	2012	During our screening program searching for cytotoxic materials from natural products, two new symmetric dimers of ent-kaurane diterpenoid, crotonkinensins C (1) and D (2), with connectivity at C-17 were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis.	Diterpenes	126-137	cytokine like 1	Homo sapiens	193-197
22065578-0	2012	Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.	Diterpenes	8-19	BCL2-like 11 (apoptosis facilitator)	Mus musculus	52-55
22065578-0	2012	Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.	Diterpenes	8-19	B cell leukemia/lymphoma 2	Mus musculus	108-113
22065578-0	2012	Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.	Diterpenes	8-19	BCL2-associated X protein	Mus musculus	145-148
22065578-3	2012	We identified a natural diterpenoid compound that induced apoptosis in bax/bak double knock-out murine embryonic fibroblasts and substantially reduced the tumor growth from these cells implanted in mice.	Diterpenes	24-35	BCL2-associated X protein	Mus musculus	71-74
22065578-3	2012	We identified a natural diterpenoid compound that induced apoptosis in bax/bak double knock-out murine embryonic fibroblasts and substantially reduced the tumor growth from these cells implanted in mice.	Diterpenes	24-35	BCL2-antagonist/killer 1	Mus musculus	75-78
22065578-6	2012	Therefore, the diterpenoid compound induces a structural and functional conversion of Bcl-2 through Bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of Bax and Bak.	Diterpenes	15-26	B cell leukemia/lymphoma 2	Mus musculus	86-91
22065578-6	2012	Therefore, the diterpenoid compound induces a structural and functional conversion of Bcl-2 through Bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of Bax and Bak.	Diterpenes	15-26	BCL2-like 11 (apoptosis facilitator)	Mus musculus	100-103
22065578-6	2012	Therefore, the diterpenoid compound induces a structural and functional conversion of Bcl-2 through Bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of Bax and Bak.	Diterpenes	15-26	BCL2-associated X protein	Mus musculus	198-201
22065578-6	2012	Therefore, the diterpenoid compound induces a structural and functional conversion of Bcl-2 through Bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of Bax and Bak.	Diterpenes	15-26	BCL2-antagonist/killer 1	Mus musculus	206-209
22447306-0	2012	The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation.	Diterpenes	11-20	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	75-81
22447306-0	2012	The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation.	Diterpenes	11-20	mitogen-activated protein kinase 1	Mus musculus	109-112
22511203-5	2012	Component analysis of these fractions revealed the diterpenes carnosol and carnosic acid as potential bioactive principles inhibiting mPGES-1 activity with IC(50) values of 5.0 muM.	Diterpenes	51-61	prostaglandin E synthase	Mus musculus	134-141
22511203-5	2012	Component analysis of these fractions revealed the diterpenes carnosol and carnosic acid as potential bioactive principles inhibiting mPGES-1 activity with IC(50) values of 5.0 muM.	Diterpenes	51-61	latexin	Homo sapiens	177-180
22734486-0	2012	Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.	Diterpenes	8-18	Sp1 transcription factor	Homo sapiens	92-113
22389469-3	2012	To explore the mechanisms underlying the anticancer activity of a natural diterpenoid, oridonin, we conducted miRNA expression profiling and statistical analyses that strongly suggested that c-Myc was a potential molecular target of oridonin.	Diterpenes	74-85	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	191-196
22036724-6	2012	Examination of the effects of the diterpene on NF-kappaB signaling showed that LAME inhibits the phosphorylation of IkappaBalpha and IkappaBbeta, preventing their degradation and the nuclear translocation of the NF-kappaB p65 subunit.	Diterpenes	34-43	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	116-128
22036724-6	2012	Examination of the effects of the diterpene on NF-kappaB signaling showed that LAME inhibits the phosphorylation of IkappaBalpha and IkappaBbeta, preventing their degradation and the nuclear translocation of the NF-kappaB p65 subunit.	Diterpenes	34-43	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	133-144
21850486-0	2011	The natural diterpene ent-16beta-17alpha-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2alpha/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells.	Diterpenes	12-21	B-cell CLL/lymphoma 2 S homeolog	Xenopus laevis	73-78
21850486-0	2011	The natural diterpene ent-16beta-17alpha-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2alpha/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells.	Diterpenes	12-21	to transcription factor AP-2 alpha L homeolog	Xenopus laevis	100-109
21850486-0	2011	The natural diterpene ent-16beta-17alpha-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2alpha/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells.	Diterpenes	12-21	E2F transcription factor 1 L homeolog	Xenopus laevis	158-162
21843517-7	2011	The most striking effects of Mg(2+) and Mn(2+) on the diterpene profile were observed for AC2 where the large inhibitory effect of BODIPY-FS in the presence of Mg(2+) was considerably reduced in the presence of Mn(2+).	Diterpenes	54-63	adenylate cyclase 2	Homo sapiens	90-93
21843517-8	2011	Sequence alignment and docking experiments confirmed an exceptional position of AC2 compared to ACs 1 and 5 with respect to the structural environment of the catalytic core and cation-dependent diterpene effects.	Diterpenes	194-203	adenylate cyclase 2	Homo sapiens	80-83
21843517-8	2011	Sequence alignment and docking experiments confirmed an exceptional position of AC2 compared to ACs 1 and 5 with respect to the structural environment of the catalytic core and cation-dependent diterpene effects.	Diterpenes	194-203	adenylate cyclase 1	Homo sapiens	96-107
22031657-2	2011	Here we compared the effects of phenolic diterpenes from rosemary on the expression of NAD(P)H: quinone oxidoreductase 1 (NQO1) in rat Clone 9 liver cells.	Diterpenes	41-51	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	87-120
22031657-2	2011	Here we compared the effects of phenolic diterpenes from rosemary on the expression of NAD(P)H: quinone oxidoreductase 1 (NQO1) in rat Clone 9 liver cells.	Diterpenes	41-51	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	122-126
22004052-1	2011	Eight new eunicellin-based diterpenoids, klymollins A-H (1-8), were isolated during the chemical investigation of the soft coral Klyxum molle from Taiwan waters.	Diterpenes	27-39	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	52-60
21963808-3	2011	In the present study, influence of the four diterpenoids on CYP1A1 mRNA expression was investigated in primary cultured mouse hepatocytes.	Diterpenes	44-56	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	60-66
21963808-8	2011	Results from molecular docking analysis of BNF and four diterpenoids on ligand binding domain of AhR were consistent with levels of CYP1A1 mRNA expressions.	Diterpenes	56-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	132-138
21963808-9	2011	Furthermore, difference of binding sites of BNF in the presence of diterpenoids might affect the synergism or inhibition of CYP1A1 expression.	Diterpenes	67-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	124-130
21620827-0	2011	The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.	Diterpenes	12-21	tumor protein p53	Homo sapiens	146-149
22071634-0	2011	Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation.	Diterpenes	0-18	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
22071634-3	2011	In both cases, treatment with diterpenes T1 and T2 protected from A/R-induced apoptosis, as deduced by a decrease in the percentage of apoptotic and caspase-3 active positive cells, a decrease in the Bcl-2/Bax ratio and an increase in the expression of antiapoptotic proteins.	Diterpenes	30-40	caspase 3	Rattus norvegicus	149-158
22071634-3	2011	In both cases, treatment with diterpenes T1 and T2 protected from A/R-induced apoptosis, as deduced by a decrease in the percentage of apoptotic and caspase-3 active positive cells, a decrease in the Bcl-2/Bax ratio and an increase in the expression of antiapoptotic proteins.	Diterpenes	30-40	BCL2, apoptosis regulator	Rattus norvegicus	200-205
22071634-3	2011	In both cases, treatment with diterpenes T1 and T2 protected from A/R-induced apoptosis, as deduced by a decrease in the percentage of apoptotic and caspase-3 active positive cells, a decrease in the Bcl-2/Bax ratio and an increase in the expression of antiapoptotic proteins.	Diterpenes	30-40	BCL2 associated X, apoptosis regulator	Rattus norvegicus	206-209
22071634-4	2011	Analysis of cell survival signaling pathways showed that diterpenes T1 and T2 added after A/R increased phospho-AKT and phospho-ERK 1/2 levels.	Diterpenes	57-67	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
22071634-4	2011	Analysis of cell survival signaling pathways showed that diterpenes T1 and T2 added after A/R increased phospho-AKT and phospho-ERK 1/2 levels.	Diterpenes	57-67	mitogen activated protein kinase 3	Rattus norvegicus	128-133
22071634-7	2011	Labdane diterpenes (T1 and T2) also exerted cardioprotective effects against A/R-induced injury in isolated cardiomyocytes and the mechanisms involved activation of specific survival signals (PI3K/AKT pathways, ERK1/2 and AMPK) and inhibition of apoptosis.	Diterpenes	8-18	AKT serine/threonine kinase 1	Rattus norvegicus	197-200
22071634-7	2011	Labdane diterpenes (T1 and T2) also exerted cardioprotective effects against A/R-induced injury in isolated cardiomyocytes and the mechanisms involved activation of specific survival signals (PI3K/AKT pathways, ERK1/2 and AMPK) and inhibition of apoptosis.	Diterpenes	8-18	mitogen activated protein kinase 3	Rattus norvegicus	211-217
22071634-7	2011	Labdane diterpenes (T1 and T2) also exerted cardioprotective effects against A/R-induced injury in isolated cardiomyocytes and the mechanisms involved activation of specific survival signals (PI3K/AKT pathways, ERK1/2 and AMPK) and inhibition of apoptosis.	Diterpenes	8-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	222-226
21795584-5	2011	The diterpenoid inhibited binding of p65 to DNA.	Diterpenes	4-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	37-40
21916433-0	2011	Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.	Diterpenes	138-147	epidermal growth factor receptor	Homo sapiens	68-100
21604687-0	2011	Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from Euphorbia species.	Diterpenes	93-103	ATP binding cassette subfamily B member 1	Homo sapiens	45-59
21438584-0	2011	Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells.	Diterpenes	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
21321609-0	2011	A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis.	Diterpenes	2-13	catenin beta 1	Homo sapiens	59-71
21321609-4	2011	The screen revealed a diterpenoid derivative, 15-oxospiramilactone (NC043) that inhibits Wnt3a or LiCl-stimulated Top-flash reporter activity in HEK293T cells and growth of colon cancer cells, SW480 and Caco-2.	Diterpenes	22-33	Wnt family member 3A	Homo sapiens	89-94
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Diterpenes	4-15	MAPK activated protein kinase 5	Homo sapiens	46-61
21308736-1	2011	Euphorbia factor L1 (EFL1) belongs to diterpenoids of genus Euphorbia.	Diterpenes	38-50	elongation factor like GTPase 1	Homo sapiens	0-19
21308736-1	2011	Euphorbia factor L1 (EFL1) belongs to diterpenoids of genus Euphorbia.	Diterpenes	38-50	elongation factor like GTPase 1	Homo sapiens	21-25
21219911-7	2011	KEY FINDINGS: Both diterpenoids inhibited the mRNA and protein expressions of CYP1A2, CYP2D6, and CYP3A4.	Diterpenes	19-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
21219911-7	2011	KEY FINDINGS: Both diterpenoids inhibited the mRNA and protein expressions of CYP1A2, CYP2D6, and CYP3A4.	Diterpenes	19-31	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	86-92
21219911-7	2011	KEY FINDINGS: Both diterpenoids inhibited the mRNA and protein expressions of CYP1A2, CYP2D6, and CYP3A4.	Diterpenes	19-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104
21219911-8	2011	Interestingly, the lowest concentration of both diterpenoids produced a more than 50% reduction in the mRNA and protein expression of CYP3A4 and this reduction was consistent with the enzyme activity.	Diterpenes	48-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140
21219911-9	2011	Further experiments revealed that both diterpenoids were also capable of attenuating the ability of dexamethasone to induce CYP3A4 expression, and 14-Deoxy-11, 12-Didehydroandrographolide tended to bind to the PXR-LBD site in a concentration-dependent manner.	Diterpenes	39-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130
21219911-9	2011	Further experiments revealed that both diterpenoids were also capable of attenuating the ability of dexamethasone to induce CYP3A4 expression, and 14-Deoxy-11, 12-Didehydroandrographolide tended to bind to the PXR-LBD site in a concentration-dependent manner.	Diterpenes	39-51	nuclear receptor subfamily 1 group I member 2	Homo sapiens	210-213
21219911-10	2011	SIGNIFICANCE: These diterpenoids are potential CYP3A4 inhibitors and the effects on CYP3A4 may be clinically significant.	Diterpenes	20-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53
21219911-10	2011	SIGNIFICANCE: These diterpenoids are potential CYP3A4 inhibitors and the effects on CYP3A4 may be clinically significant.	Diterpenes	20-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Diterpenes	4-15	MAPK activated protein kinase 5	Homo sapiens	63-66
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Diterpenes	4-15	MAPK activated protein kinase 5	Homo sapiens	67-71
20640477-3	2011	We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity.	Diterpenes	18-29	MAPK activated protein kinase 5	Homo sapiens	70-73
20739655-2	2010	Here, we identify a novel natural ent-kaurene diterpenoid derived from Isodon pharicus leaves, called pharicin B, that can rapidly stabilize RAR-alpha protein in various acute myeloid leukemic (AML) cell lines and primary leukemic cells from AML patients, even in the presence of ATRA, which is known to induce the loss of RAR-alpha protein.	Diterpenes	46-57	retinoic acid receptor alpha	Homo sapiens	141-150
20669088-3	2011	Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells.	Diterpenes	12-24	chromobox 8	Homo sapiens	81-84
20728594-3	2010	The purpose of this study is to evaluate and compare the anti-inflammatory effect of diterpenoids isolated from Andrographis paniculata, including dehydroandrographolide (AP1), andrographolide (AP2) and neoandrographolide (AP3), on the production of inflammatory cytokines and COX activities.	Diterpenes	85-97	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-174
20822783-0	2010	TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15).	Diterpenes	21-33	tumor necrosis factor	Mus musculus	0-9
20822783-0	2010	TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15).	Diterpenes	225-237	tumor necrosis factor	Mus musculus	0-9
20822783-0	2010	TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15).	Diterpenes	21-32	tumor necrosis factor	Mus musculus	0-9
20822783-0	2010	TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15).	Diterpenes	225-237	tumor necrosis factor	Mus musculus	0-9
20594187-8	2010	Triptolide (diterpenoid triepoxyde), a purified component of a traditional Chinese medicine, extracted from a shrub-like vine named Trypterygium wilfordii Hook F (TWHF) inhibits transcriptional activation of NF-kappaB and downregulates the expression of various NF-kappaB-regulated genes.	Diterpenes	12-23	nuclear factor kappa B subunit 1	Homo sapiens	208-217
20594187-8	2010	Triptolide (diterpenoid triepoxyde), a purified component of a traditional Chinese medicine, extracted from a shrub-like vine named Trypterygium wilfordii Hook F (TWHF) inhibits transcriptional activation of NF-kappaB and downregulates the expression of various NF-kappaB-regulated genes.	Diterpenes	12-23	nuclear factor kappa B subunit 1	Homo sapiens	262-271
20379953-2	2010	We found that two diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2.	Diterpenes	18-30	interleukin 6	Homo sapiens	96-100
20736335-4	2010	Through molecular modeling, we found that carnosol, a dietary diterpene, fits within the ligand-binding domain of both AR and ER-alpha.	Diterpenes	62-71	androgen receptor	Homo sapiens	119-121
20350537-0	2010	Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis.	Diterpenes	25-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-106
20350537-0	2010	Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis.	Diterpenes	25-35	butyrylcholinesterase	Homo sapiens	111-132
20350537-5	2010	Here we characterized the inhibition property of these two diterpenoids towards human AChE and butyrylcholinesterase (BChE).	Diterpenes	59-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90
20350537-5	2010	Here we characterized the inhibition property of these two diterpenoids towards human AChE and butyrylcholinesterase (BChE).	Diterpenes	59-71	butyrylcholinesterase	Homo sapiens	95-116
20350537-5	2010	Here we characterized the inhibition property of these two diterpenoids towards human AChE and butyrylcholinesterase (BChE).	Diterpenes	59-71	butyrylcholinesterase	Homo sapiens	118-122
20736335-4	2010	Through molecular modeling, we found that carnosol, a dietary diterpene, fits within the ligand-binding domain of both AR and ER-alpha.	Diterpenes	62-71	estrogen receptor 1	Homo sapiens	126-134
20495852-3	2010	The diterpene-free tobacco line was generated by silencing the major tobacco diterpene synthases, which were found to be encoded by a family of four highly similar genes (NsCBTS-2a, NsCBTS-2b, NsCBTS-3 and NsCBTS-4), one of which is a pseudogene.	Diterpenes	4-13	germacrene C synthase-like	Nicotiana sylvestris	193-201
20178071-0	2010	SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis.	Diterpenes	17-29	sirtuin 1	Homo sapiens	0-5
20178071-6	2010	This is the first report showing the potential of ENT-kaurane diterpenoids as a new class of natural SIRT1 inhibitors.	Diterpenes	62-74	sirtuin 1	Homo sapiens	101-106
20403343-0	2010	The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.	Diterpenes	11-20	TNF superfamily member 10	Homo sapiens	40-45
20403343-0	2010	The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.	Diterpenes	11-20	BCL2 apoptosis regulator	Homo sapiens	121-126
20403343-0	2010	The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.	Diterpenes	11-20	CASP8 and FADD like apoptosis regulator	Homo sapiens	131-137
19288401-6	2009	Six tricyclic diterpenoids used in this experiment suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.	Diterpenes	14-26	formyl peptide receptor 1	Homo sapiens	140-144
19795923-4	2009	In human liver microsomes, 7-epi-cephalomannine was subject to C-13 lateral chain (M-1) and diterpenoid core monohydroxylation (M-2), mediated by cytochrome P450 (CYP) 3A4 and CYP2C8, respectively.	Diterpenes	92-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	146-171
19768546-0	2009	The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK.	Diterpenes	11-20	AKT serine/threonine kinase 1	Homo sapiens	103-106
19768546-0	2009	The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK.	Diterpenes	11-20	mitogen-activated protein kinase 8	Homo sapiens	141-144
19447224-1	2009	The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I-VIII.	Diterpenes	4-13	cytochrome c oxidase subunit 8A	Homo sapiens	108-112
19447224-9	2009	In the first step, diterpenes, regardless of their substitution pattern, promote C1/C2 assembly.	Diterpenes	19-29	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	81-86
19719246-0	2009	Inhibition of NF-kappaB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages.	Diterpenes	69-81	nitric oxide synthase 2, inducible	Mus musculus	39-43
18674641-0	2008	Diterpenes drive Th1 polarization depending on IL-12.	Diterpenes	0-10	negative elongation factor complex member C/D	Homo sapiens	17-20
19168281-4	2009	The addition of triptolide (a diterpenoid triepoxide, which blocked MKP-1 induction) abolished the inhibitory effects by RGZ.	Diterpenes	30-41	dual specificity phosphatase 1	Homo sapiens	68-73
19275691-5	2009	In the present review, molecular basis of the anti-inflammatory action of diterpenoids is presented with special emphasis on their ability to modulate critical cell signaling pathways involved in the inflammatory response of the body such as nuclear transcription factor-kappaB (NF-kappaB) activation.	Diterpenes	74-86	nuclear factor kappa B subunit 1	Homo sapiens	242-277
19275691-5	2009	In the present review, molecular basis of the anti-inflammatory action of diterpenoids is presented with special emphasis on their ability to modulate critical cell signaling pathways involved in the inflammatory response of the body such as nuclear transcription factor-kappaB (NF-kappaB) activation.	Diterpenes	74-86	nuclear factor kappa B subunit 1	Homo sapiens	279-288
19275691-8	2009	Hence, this article also introduces our recently elucidated findings about the potential of labdane diterpenoids as anti-inflammatory agents due to their ability to inhibit NF-kappaB.	Diterpenes	100-112	nuclear factor kappa B subunit 1	Homo sapiens	173-182
18674641-8	2008	These results suggest that some diterpenes modulate human DC function in a fashion that favors Th1 cell polarization and may be used on DC-based vaccines for cancer immunotherapy.	Diterpenes	32-42	negative elongation factor complex member C/D	Homo sapiens	95-98
18664395-0	2008	Ent-3,4-seco-labdane and ent-labdane diterpenoids from Croton stipuliformis (Euphorbiaceae).	Diterpenes	37-49	solute carrier family 29 member 3	Homo sapiens	0-5
18824363-4	2008	The molecular orbital energies (HOMO and LUMO) of diterpenes 1-6 and 7-13, previously isolated, have also been calculated in order to estimate their probable charge transfer interactions with P-gp.	Diterpenes	50-60	phosphoglycolate phosphatase	Homo sapiens	192-196
18512813-11	2008	Production of tumor necrosis factor, interleukin-6, and monocyte chemoattractant protein 1 by spleen cells was also decreased after diterpenoid therapy.	Diterpenes	132-143	tumor necrosis factor	Mus musculus	14-35
18589462-2	2008	Despite the opportunity for free rotation about the C-9:C-10 bond, the chemistry of the ring B of this diterpenoid is dominated by neighbouring group participation between C-6, C-7 and C-19.	Diterpenes	103-114	complement C9	Homo sapiens	52-55
18589462-2	2008	Despite the opportunity for free rotation about the C-9:C-10 bond, the chemistry of the ring B of this diterpenoid is dominated by neighbouring group participation between C-6, C-7 and C-19.	Diterpenes	103-114	complement C6	Homo sapiens	172-175
18589462-2	2008	Despite the opportunity for free rotation about the C-9:C-10 bond, the chemistry of the ring B of this diterpenoid is dominated by neighbouring group participation between C-6, C-7 and C-19.	Diterpenes	103-114	complement C7	Homo sapiens	177-180
18593583-0	2008	The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress.	Diterpenes	11-20	heme oxygenase 1	Homo sapiens	37-53
18593583-0	2008	The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress.	Diterpenes	11-20	mitogen-activated protein kinase 14	Homo sapiens	71-74
18593583-0	2008	The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress.	Diterpenes	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
18512813-11	2008	Production of tumor necrosis factor, interleukin-6, and monocyte chemoattractant protein 1 by spleen cells was also decreased after diterpenoid therapy.	Diterpenes	132-143	interleukin 6	Mus musculus	37-50
18512813-11	2008	Production of tumor necrosis factor, interleukin-6, and monocyte chemoattractant protein 1 by spleen cells was also decreased after diterpenoid therapy.	Diterpenes	132-143	chemokine (C-C motif) ligand 2	Mus musculus	56-90
18028974-6	2008	Treatment of mouse embryonic fibroblasts (MEFs) from nrf2(+/+) mice with either coffee or the coffee-specific diterpenes cafestol and kahweol (C+K) increased NQO1 mRNA up to 9-fold.	Diterpenes	110-120	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
18334227-0	2008	Diterpene, 16-phyllocladanol enhances Th1 polarization induced by LPS-primed DC, but not TNF-alpha-primed DC.	Diterpenes	0-9	negative elongation factor complex member C/D	Homo sapiens	38-41
18190942-3	2008	These diterpenoids reduced the production of nitric oxide (NO), prostaglandin E2, and tumor necrosis factor-alpha in LPS-activated RAW 264.7 macrophages, with IC50 in the range 1-10 microM.	Diterpenes	6-18	tumor necrosis factor	Mus musculus	64-113
18190942-5	2008	Examination of the effects of these diterpenoids on nuclear factor kappaB signaling showed that both compounds inhibit the phosphorylation of IkappaBalpha and IkappaBbeta, preventing their degradation and the nuclear translocation of the NF-kappaB p65 subunit.	Diterpenes	36-48	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	142-154
18190942-5	2008	Examination of the effects of these diterpenoids on nuclear factor kappaB signaling showed that both compounds inhibit the phosphorylation of IkappaBalpha and IkappaBbeta, preventing their degradation and the nuclear translocation of the NF-kappaB p65 subunit.	Diterpenes	36-48	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	159-170
18345642-1	2008	Four new briarane-type diterpenoids, brianodins A-D ( 1- 4), were isolated from a soft coral, Pachyclavularia sp., and the structures and relative stereochemistry of 1- 4 were elucidated on the basis of spectroscopic data.	Diterpenes	23-35	AD14	Homo sapiens	48-58
18028974-6	2008	Treatment of mouse embryonic fibroblasts (MEFs) from nrf2(+/+) mice with either coffee or the coffee-specific diterpenes cafestol and kahweol (C+K) increased NQO1 mRNA up to 9-fold.	Diterpenes	110-120	NAD(P)H dehydrogenase, quinone 1	Mus musculus	158-162
17595105-0	2007	Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.	Diterpenes	114-126	taste 2 receptor member 46	Homo sapiens	48-56
19356045-0	2007	Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.	Diterpenes	129-140	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	15-29
17640057-1	2007	Melissoidesin G (MOG) is a new diterpenoid purified from Isodon melissoides, a plant used in Chinese traditional medicine as antitumor and anti-inflammatory agents.	Diterpenes	31-42	myelin oligodendrocyte glycoprotein	Homo sapiens	17-20
17618303-7	2007	The diterpenes prevented apoptosis through a mechanism compatible with the inhibition of caspase-3 activation, release of cytochrome c to the cytosol and p53 overexpression, as well as an alteration in the levels of proteins of the Bcl-2 family, in particular, the levels of Bax.	Diterpenes	4-14	caspase 3	Mus musculus	89-98
17618303-7	2007	The diterpenes prevented apoptosis through a mechanism compatible with the inhibition of caspase-3 activation, release of cytochrome c to the cytosol and p53 overexpression, as well as an alteration in the levels of proteins of the Bcl-2 family, in particular, the levels of Bax.	Diterpenes	4-14	transformation related protein 53, pseudogene	Mus musculus	154-157
17618303-7	2007	The diterpenes prevented apoptosis through a mechanism compatible with the inhibition of caspase-3 activation, release of cytochrome c to the cytosol and p53 overexpression, as well as an alteration in the levels of proteins of the Bcl-2 family, in particular, the levels of Bax.	Diterpenes	4-14	B cell leukemia/lymphoma 2	Mus musculus	232-237
17618303-7	2007	The diterpenes prevented apoptosis through a mechanism compatible with the inhibition of caspase-3 activation, release of cytochrome c to the cytosol and p53 overexpression, as well as an alteration in the levels of proteins of the Bcl-2 family, in particular, the levels of Bax.	Diterpenes	4-14	BCL2-associated X protein	Mus musculus	275-278
17618303-8	2007	Cleavage of poly(ADP-ribose) polymerase, a well-established caspase substrate, was reduced by these diterpenes.	Diterpenes	100-110	poly (ADP-ribose) polymerase family, member 1	Mus musculus	12-39
17595105-5	2007	By further investigation of its agonist pattern, we characterized hTAS2R46 as a bitter receptor broadly tuned to sesquiterpene lactones and to clerodane and labdane diterpenoids as well as to the unrelated bitter substances strychnine and denatonium.	Diterpenes	165-177	taste 2 receptor member 46	Homo sapiens	66-74
19093450-4	2007	The participation of efflux transporters such as P-glycoprotein and MRP2 in andrographolide transport was then examined, since andrographolide is a diterpene compound and some diterpene compounds are known as P-glycoprotein substrates.	Diterpenes	176-185	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	209-223
17583950-0	2007	Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.	Diterpenes	9-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-97
17365701-1	2007	Chemical examination of the petrol ether (60-80) extract of the aerial parts of Calceolaria alba R. et Pav., collected in Santa Juana, VIII Region, Chile, resulted in the isolation of 3 new diterpenoids.	Diterpenes	190-202	cytochrome c oxidase subunit 8A	Homo sapiens	135-139
17258704-8	2007	Similar cytotoxic and pro-apoptotic effects were also attained by treating the HT-29 cells with another diterpenoid triptolide, but its actions on cell cycle progression and on the upstream transcriptional regulation of NAG-1 both took place in a less coherent manner.	Diterpenes	104-115	growth differentiation factor 15	Homo sapiens	220-225
17329499-3	2007	We found that diterpenes with different substitutions at the C4 position in ring A are potent activators of liver X receptors (LXRalpha and LXRbeta) in both macrophage cell lines from human and mouse origin and primary murine macrophages.	Diterpenes	14-24	nuclear receptor subfamily 1 group H member 3	Homo sapiens	127-135
17329499-3	2007	We found that diterpenes with different substitutions at the C4 position in ring A are potent activators of liver X receptors (LXRalpha and LXRbeta) in both macrophage cell lines from human and mouse origin and primary murine macrophages.	Diterpenes	14-24	nuclear receptor subfamily 1 group H member 2	Homo sapiens	140-147
17329499-4	2007	Activation of LXR by these diterpenes was evaluated in transient transfection assays and gene expression analysis of known LXR-target genes, including the cholesterol transporters ABCA1 and ABCG1, the sterol regulatory element-binding protein 1c, and the apoptosis inhibitor of macrophages (Spalpha).	Diterpenes	27-37	nuclear receptor subfamily 1, group H, member 3	Mus musculus	14-17
17329499-4	2007	Activation of LXR by these diterpenes was evaluated in transient transfection assays and gene expression analysis of known LXR-target genes, including the cholesterol transporters ABCA1 and ABCG1, the sterol regulatory element-binding protein 1c, and the apoptosis inhibitor of macrophages (Spalpha).	Diterpenes	27-37	nuclear receptor subfamily 1, group H, member 3	Mus musculus	123-126
17329499-4	2007	Activation of LXR by these diterpenes was evaluated in transient transfection assays and gene expression analysis of known LXR-target genes, including the cholesterol transporters ABCA1 and ABCG1, the sterol regulatory element-binding protein 1c, and the apoptosis inhibitor of macrophages (Spalpha).	Diterpenes	27-37	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	180-185
17329499-4	2007	Activation of LXR by these diterpenes was evaluated in transient transfection assays and gene expression analysis of known LXR-target genes, including the cholesterol transporters ABCA1 and ABCG1, the sterol regulatory element-binding protein 1c, and the apoptosis inhibitor of macrophages (Spalpha).	Diterpenes	27-37	surfactant associated protein A1	Mus musculus	291-298
17329499-6	2007	It is interesting that these diterpenes antagonize inflammatory gene expression mainly through LXR-dependent mechanisms, indicating that these compounds can activate both LXR activation and repression functions.	Diterpenes	29-39	nuclear receptor subfamily 1, group H, member 3	Mus musculus	95-98
17329499-6	2007	It is interesting that these diterpenes antagonize inflammatory gene expression mainly through LXR-dependent mechanisms, indicating that these compounds can activate both LXR activation and repression functions.	Diterpenes	29-39	nuclear receptor subfamily 1, group H, member 3	Mus musculus	171-174
17329499-9	2007	These results show the ability of certain acanthoic acid diterpenes to activate efficiently both LXRs and suggest that these compounds can exert beneficial effects from a cardiovascular standpoint through LXR-dependent mechanisms.	Diterpenes	57-67	nuclear receptor subfamily 1, group H, member 3	Mus musculus	97-100
17337280-0	2007	A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells.	Diterpenes	17-26	Rac family small GTPase 1	Rattus norvegicus	71-75
17338565-0	2007	Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-kappaB activation and NO production in macrophage RAW264.7 cells.	Diterpenes	8-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-70
17360534-4	2007	Here we show that triptolide, the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a PC2-dependent mechanism.	Diterpenes	41-50	polycystin 2, transient receptor potential cation channel	Mus musculus	130-133
17077562-2	2006	The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.	Diterpenes	79-88	sarcosinemia autosomal recessive	Mus musculus	52-55
16626958-2	2006	Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.	Diterpenes	131-143	sarcosinemia autosomal recessive	Mus musculus	48-51
17152989-4	2006	We recently reported carnosic acid and carnosol, both being diterpenes found in the labiate herbs sage and rosemary, to be activators of PPARgamma.	Diterpenes	60-70	peroxisome proliferator activated receptor gamma	Homo sapiens	137-146
16858665-0	2006	Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma.	Diterpenes	37-46	peroxisome proliferator activated receptor gamma	Homo sapiens	125-173
16828562-2	2006	The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells.	Diterpenes	91-101	sarcosinemia autosomal recessive	Mus musculus	52-55
16797002-2	2006	We recently found that the tanshinone IIA, a diterpene isolated from Salvia miltiorrhiza (S. miltiorrhiza), reduced the production of pro-inflammatory mediators in RAW 264.7 cells stimulated with lipopolysaccharide (LPS).	Diterpenes	45-54	ATPase, class II, type 9A	Mus musculus	38-41
16597370-8	2006	Tanshinone IIA was the main diterpene quinone in S. miltiorrhiza.	Diterpenes	28-37	ATPase, class II, type 9A	Mus musculus	11-14
16724849-1	2006	Four new cembrane diterpenes, sarcophytonolides E-H (1-4), were isolated from the Hainan soft coral Sarcophyton latum.	Diterpenes	18-28	epoxide hydrolase 3	Homo sapiens	48-56
15770551-2	2005	Indeed, we have found that an ent-kaurene diterpene, ent-11alpha-hydroxy-16-kauren-15-one (KD), induced apoptosis via caspase-8 activation in human promyelocytic leukemia HL-60 cells.	Diterpenes	42-51	caspase 8	Homo sapiens	118-127
16317828-1	2005	Geranylgeranyltransferase I (GGTase I) catalyzes the post-translational transfer of lyophilic diterpenoid geranylgeranyl to the cysteine residue of proteins terminating with a CaaX motif such as Rho1p and Cdc42p.	Diterpenes	94-105	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	195-200
16317828-1	2005	Geranylgeranyltransferase I (GGTase I) catalyzes the post-translational transfer of lyophilic diterpenoid geranylgeranyl to the cysteine residue of proteins terminating with a CaaX motif such as Rho1p and Cdc42p.	Diterpenes	94-105	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	205-211
16176802-0	2005	Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.	Diterpenes	171-183	nuclear factor kappa B subunit 1	Homo sapiens	74-83
15938198-0	2005	Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.	Diterpenes	33-44	tyrosinase	Homo sapiens	0-10
16041644-1	2005	14-Deoxyandrographolide (14-DAP) is a labdane diterpene isolated from Andrographis paniculata with previously reported calcium channel blocking activity.	Diterpenes	38-55	death associated protein	Bos taurus	28-31
16614480-1	2006	Previous studies reported that kahweol, a coffee-specific diterpene, inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in cultured lipopolysaccharide-activated macrophages.	Diterpenes	58-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	78-94
16614480-1	2006	Previous studies reported that kahweol, a coffee-specific diterpene, inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in cultured lipopolysaccharide-activated macrophages.	Diterpenes	58-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	96-101
16614480-1	2006	Previous studies reported that kahweol, a coffee-specific diterpene, inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in cultured lipopolysaccharide-activated macrophages.	Diterpenes	58-67	nitric oxide synthase 2	Rattus norvegicus	107-138
16614480-1	2006	Previous studies reported that kahweol, a coffee-specific diterpene, inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in cultured lipopolysaccharide-activated macrophages.	Diterpenes	58-67	nitric oxide synthase 2	Rattus norvegicus	140-144
16454745-6	2006	Thus we determined the effect of structurally unrelated diterpenes, triterpenes and carotenoids on reversal of multidrug resistance in MDR-1 gene-transfected L1210 mouse lymphoma cells and MDR mediated multidrug resistance of human breast cancer cells MDA-MB-231 (HTB-26) and MCF-7.	Diterpenes	56-66	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	135-140
16337204-3	2005	NtPDR3 was found to be induced in suspension cells treated with methyl jasmonate, salicylic acid, 1-naphthalene acetic acid, or cembrene, a macrocyclic diterpene.	Diterpenes	152-161	pleiotropic drug resistance protein 3	Nicotiana tabacum	0-6
16307364-8	2005	The Fusarium-inducible nature of An2 is also consistent with a previous report that cell-free extracts from maize seedlings produce ent-CPP derived diterpenes in response to Fusarium infection.	Diterpenes	148-158	ent-copalyl diphosphate synthase 2, chloroplastic	Zea mays	33-36
15993607-0	2005	Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone.	Diterpenes	5-16	cell division cycle 25B	Homo sapiens	31-37
14672753-7	2004	Extensive pulegone metabolism generated p-cresol that was a glutathione depletory, and the furan ring of the diterpenoids in germander was oxidized by CYP3A4 to reactive epoxide which reacts with proteins such as CYP3A and epoxide hydrolase.	Diterpenes	109-121	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157
15652238-6	2005	CCRF-CEM cells, a well-studied model of glucocorticoid and cAMP-induced apoptosis, differed from B-CLL cells in that stimulation of adenylyl cyclase with the diterpene forskolin was required to increase both glucocorticoid-mediated apoptosis and GRE activation, while PDE4 inhibition had no effect.	Diterpenes	158-167	phosphodiesterase 4A	Homo sapiens	268-272
15816559-6	2005	CONCLUSION: We show here, for the first time, that a trachylobane diterpene is able to induce apoptosis in human promyelocytic leukemia cells via caspase-3 activation in a concentration-dependent manner.	Diterpenes	66-75	caspase 3	Homo sapiens	146-155
15540220-0	2005	A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.	Diterpenes	26-36	NFKB inhibitor alpha	Homo sapiens	85-97
15620241-0	2004	Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells.	Diterpenes	24-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-111
15368659-0	2004	An ent-kaurene diterpene enhances apoptosis induced by tumor necrosis factor in human leukemia cells.	Diterpenes	15-24	tumor necrosis factor	Homo sapiens	55-76
15290691-2	2004	Although we were unable to obtain a suitable crystal, the absolute configuration of the irregular diterpene skeleton was determined using two other techniques: a circular dichroism (CD) protocol based on a tetraarylporphyrin molecular tweezer that allowed prediction of the absolute stereochemistry on a microscale level, and a method employing differences in NMR shifts from derivatization of the naturally occurring acid 1 with enantiomers of a phenylglycine methyl ester (PGME) chiral anisotropic reagent.	Diterpenes	98-107	mediator complex subunit 25	Homo sapiens	418-424
15161936-0	2004	Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway.	Diterpenes	8-17	caspase 8	Homo sapiens	77-86
15327829-0	2004	The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages.	Diterpenes	11-20	nitric oxide synthase 2	Homo sapiens	42-73
14692730-5	2003	We suggest that the unsaturation at C-15 and saturation on ring A may be critical structural components for cytotoxicity in these diterpenes.	Diterpenes	130-140	placenta-specific 8	Mus musculus	36-40
14627387-1	2003	[structure: see text] Three novel diterpenes, called cyanthiwigins AB (1), AC (2), and AD (3), were isolated from the Jamaican sponge Myrmekioderma styx.	Diterpenes	34-44	serine/threonine/tyrosine interacting protein	Homo sapiens	148-152
14568079-2	2003	Evaluated in a panel of human cancer cell lines, the 16-hydroxylabade diterpene was the most active, showing an ED(50) value of 0.3 mug/ml against Lu1 (human lung cancer) cells.	Diterpenes	70-79	PDZ domain containing 4	Mus musculus	147-150
14560922-0	2003	Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-alpha secretion from trypsin-stimulated HMC-1 cells.	Diterpenes	34-46	tumor necrosis factor	Homo sapiens	77-86
14659977-1	2004	Effects of tanshinone IIA, an active diterpene quinone of the herbal medicine Salvia miltiorrhiza (Danshen), on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in the arylhydrocarbon (Ah)-responsive C57BL/6J (B6) and nonresponsive DBA/2J (D2) mice.	Diterpenes	37-46	ATPase, class II, type 9A	Mus musculus	22-25
12851037-0	2003	Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.	Diterpenes	0-9	ATPase, class II, type 9A	Mus musculus	29-32
12851037-2	2003	Tanshinone IIA is the main active diterpene quinone in the herbal medicine Salvia miltiorrhiza.	Diterpenes	34-43	ATPase, class II, type 9A	Mus musculus	11-14
12809367-9	2003	The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects.	Diterpenes	104-114	prolactin	Homo sapiens	172-181
12736467-0	2003	Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum.	Diterpenes	67-79	tumor necrosis factor	Homo sapiens	21-30
12736467-0	2003	Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum.	Diterpenes	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12141857-5	2002	Additionally, the known diterpene 16-hydroxyrosmanol (10) and a new aromatic diterpene 11 were obtained from 16-hydroxycarnosol (9) by reaction with Ph3P/NBS in CH2Cl2.	Diterpenes	24-33	nibrin	Homo sapiens	154-157
12673027-3	2003	All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.	Diterpenes	17-27	toll-like receptor 4	Mus musculus	90-93
12585861-0	2003	Synthesis of C-17-functionalized spongiane diterpenes: diastereoselective synthesis of (-)-spongian-16-oxo-17-al, (-)-acetyldendrillol-1, and (-)-aplyroseol-14.	Diterpenes	43-53	cytokine like 1	Homo sapiens	13-17
12221600-0	2002	Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii.	Diterpenes	56-68	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
12612453-0	2003	Inhibitory effect of norditerpenes on LPS-induced TNF-alpha production from the Okinawan soft coral, Sinularia sp.	Diterpenes	21-34	toll-like receptor 4	Mus musculus	38-41
12612453-0	2003	Inhibitory effect of norditerpenes on LPS-induced TNF-alpha production from the Okinawan soft coral, Sinularia sp.	Diterpenes	21-34	tumor necrosis factor	Mus musculus	50-59
12608860-2	2003	The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells.	Diterpenes	13-23	toll-like receptor 4	Mus musculus	140-143
12506998-1	2002	The labdane diterpene derivative, syn-copalol [(+)-5] is the alcohol part of syn-copalyl diphosphate [(+)-4].	Diterpenes	12-21	synemin	Homo sapiens	34-37
12506998-1	2002	The labdane diterpene derivative, syn-copalol [(+)-5] is the alcohol part of syn-copalyl diphosphate [(+)-4].	Diterpenes	12-21	synemin	Homo sapiens	77-80
12149019-1	2002	To examine the mechanism of the cyclization reaction catalyzed by aphidicolan-16beta-ol synthase (ACS), which is a key enzyme in the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha, skeletal rearrangement of 2a and biomimetic cyclization of 4b were employed.	Diterpenes	149-158	phospholipase A2 group XV	Homo sapiens	66-96
12149019-1	2002	To examine the mechanism of the cyclization reaction catalyzed by aphidicolan-16beta-ol synthase (ACS), which is a key enzyme in the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha, skeletal rearrangement of 2a and biomimetic cyclization of 4b were employed.	Diterpenes	149-158	phospholipase A2 group XV	Homo sapiens	98-101
11488452-0	2001	Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells.	Diterpenes	8-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
11877450-0	2002	Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes.	Diterpenes	8-17	nuclear factor kappa B subunit 1	Homo sapiens	42-52
11877450-0	2002	Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes.	Diterpenes	8-17	nuclear factor kappa B subunit 1	Homo sapiens	103-106
11877450-0	2002	Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes.	Diterpenes	8-17	nuclear factor kappa B subunit 1	Homo sapiens	150-160
11877450-2	2002	We have previously shown that kamebakaurin and other three kaurane diterpenes selectively inhibit activation of transcription factor NF-kappaB, a central mediator of apoptosis and immune responses.	Diterpenes	67-77	nuclear factor kappa B subunit 1	Homo sapiens	133-142
11999122-6	2002	A large number of compounds are currently known as NF-kappaB modulators and include the isoprenoids, most notably kaurene diterpenoids and members of the sesquiterpene lactones class, several phenolics including curcumin and flavonoids such as silybin.	Diterpenes	122-134	nuclear factor kappa B subunit 1	Homo sapiens	51-60
11807975-1	2002	In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined.	Diterpenes	59-70	linoleate 9S-lipoxygenase-4	Glycine max	92-104
11807975-1	2002	In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined.	Diterpenes	59-70	putative NADH-dependent hydroxypyruvate reductase	Glycine max	124-138
11456084-1	2001	The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported.	Diterpenes	61-71	solute carrier family 29 member 3	Homo sapiens	85-90
12061897-4	2002	In this paper, we show that the plant SpTUR2 PDR5-like ABC transporter is localised to the plasma membrane and that expression of this protein in Arabidopsis leads to the acquisition of resistance to the diterpenoid antifungal agent sclareol.	Diterpenes	204-215	pleiotropic drug resistance 5	Arabidopsis thaliana	45-49
11939783-6	2002	However, the saturated diterpenoid phytanic acid (PA) and docosahexaenoic acid, which have been recently shown to activate the nuclear receptor, RXR, competed with 9-cis-RA labeling, showing high affinity for the 9-cis-RA binding site.	Diterpenes	23-34	retinoid X receptor alpha	Homo sapiens	145-148
11488452-5	2001	These results suggest that kaurane diterpenes could exert their inhibitory effects on the production of NO and PGE2 through the suppression of NF-kappaB activation, and be partially responsible for the anti-inflammatory activities of the genus Isodon.	Diterpenes	35-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
11346484-5	2001	In addition, these diterpenes induced significantly GST Yc2, the most efficient rat GST subunit involved in AFBO detoxification.	Diterpenes	19-29	glutathione S-transferase alpha 3	Rattus norvegicus	52-59
11329783-2	2001	TXL is a novel plant-derived anticancer agent that is a diterpene derivative possessing the taxane ring.	Diterpenes	56-65	thioredoxin like 1	Homo sapiens	0-3
11418060-0	2001	Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition.	Diterpenes	68-78	nerve growth factor	Homo sapiens	46-49
11418060-2	2001	This strategy provides efficient access (14 steps and 13% overall yield) to potential analogues as well as precursors of nerve growth factor (NGF)-inducing diterpenes.	Diterpenes	156-166	nerve growth factor	Homo sapiens	121-140
11418060-2	2001	This strategy provides efficient access (14 steps and 13% overall yield) to potential analogues as well as precursors of nerve growth factor (NGF)-inducing diterpenes.	Diterpenes	156-166	nerve growth factor	Homo sapiens	142-145
11337016-0	2001	Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis.	Diterpenes	13-23	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
11278990-4	2001	These diterpenes inhibit NF-kappaB and IkappaB kinase (IKK) activation in vivo but failed to affect in vitro the function of NF-kappaB, the phosphorylation and targeting of IkappaBalpha, and the activity of IKK-2.	Diterpenes	6-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
11278990-5	2001	Transient expression of NF-kappaB-inducing kinase (NIK) activated the IKK complex and NF-kappaB, a process that was inhibited by kaurenes, indicating that the inhibition of NIK was one of the targets of these diterpenes.	Diterpenes	209-219	mitogen-activated protein kinase kinase kinase 14	Mus musculus	24-49
11278990-5	2001	Transient expression of NF-kappaB-inducing kinase (NIK) activated the IKK complex and NF-kappaB, a process that was inhibited by kaurenes, indicating that the inhibition of NIK was one of the targets of these diterpenes.	Diterpenes	209-219	mitogen-activated protein kinase kinase kinase 14	Mus musculus	51-54
11278990-5	2001	Transient expression of NF-kappaB-inducing kinase (NIK) activated the IKK complex and NF-kappaB, a process that was inhibited by kaurenes, indicating that the inhibition of NIK was one of the targets of these diterpenes.	Diterpenes	209-219	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-33
11278990-5	2001	Transient expression of NF-kappaB-inducing kinase (NIK) activated the IKK complex and NF-kappaB, a process that was inhibited by kaurenes, indicating that the inhibition of NIK was one of the targets of these diterpenes.	Diterpenes	209-219	mitogen-activated protein kinase kinase kinase 14	Mus musculus	173-176
11249127-0	2001	Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE.	Diterpenes	41-51	solute carrier family 9 member A6	Homo sapiens	95-99
11249127-2	2001	Antimicrobial activities of synthesized phenolic diterpenes and their related compounds against MRSA and VRE were evaluated.	Diterpenes	49-59	solute carrier family 9 member A6	Homo sapiens	96-100
10945480-2	1999	Taxol, a diterpenoid compound, that has been demonstrated to possess a potent antitumour activity, is shown to extract Na+, K+, Mg2+ and Ca2+ ions from the aqueous solution to the organic phase with preference for Ca2+ ions.	Diterpenes	9-20	mucin 7, secreted	Homo sapiens	128-131
9927320-6	1999	Similarly, the combination of IL-1beta and the diterpene forskolin (but not the inactive analog 1,9-dideoxyforskolin) or cholera toxin also resulted in a synergistic stimulation of C6 glioma IL-6 release.	Diterpenes	47-56	interleukin 6	Rattus norvegicus	191-195
11124749-0	2001	The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects.	Diterpenes	11-20	apolipoprotein B	Homo sapiens	111-127
11142848-2	2000	The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14.	Diterpenes	69-79	complement C3	Homo sapiens	95-98
10915737-9	2000	In conclusion, CYP3A activates skullcap diterpenoids into reactive metabolites that deplete cellular thiols and increase cell [Ca(2+)].	Diterpenes	40-52	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	15-20
10516639-5	1999	The pharmacological effects of this diterpene have been analysed on the activation of the macrophage cell line J774 with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	Diterpenes	36-45	interferon gamma	Mus musculus	150-166
10516639-5	1999	The pharmacological effects of this diterpene have been analysed on the activation of the macrophage cell line J774 with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	Diterpenes	36-45	interferon gamma	Mus musculus	168-177
10516639-10	1999	The levels of this enzyme decreased significantly in the presence of andalusol (IC50=10.5 microM), suggesting that this diterpene inhibited NOS-2 expression.	Diterpenes	120-129	nitric oxide synthase 2, inducible	Mus musculus	140-145
9868383-4	1998	These species were found to be divided into four groups by the cluster analysis of the values of oxidation state of C-1 to C-20 in the diterpenoids of the Rabdosia.	Diterpenes	135-147	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	116-127
9834175-2	1998	Compound 1 is a diterpene with a peroxide ring in the side chain, and 2 is an unusual six/five-membered ring diterpene with an ethyl unit at C-2.	Diterpenes	110-119	complement C2	Homo sapiens	142-145
8917367-3	1996	The methanol extract of a Brazilian propolis was fractionated by HPLC, and a tumoricidal substance was isolated and characterized as a new clerodane diterpenoid (PMS-1) with a molecular formula of C20H32O3 (MW: 320).	Diterpenes	149-160	PMS1 homolog 1, mismatch repair system component	Mus musculus	162-167
9234024-13	1997	However, the Lp(a)-reducing potency of coffee diterpenes may subside in the long run, and their adverse side effects preclude their use as lipoprotein(a)-reducing agents.	Diterpenes	46-56	lipoprotein(a)	Homo sapiens	13-17
9226413-1	1997	The diterpene forskolin inhibits nicotine-evoked chromaffin cell Ca2+ influx, scinderin redistribution, F-actin disassembly and catecholamine secretion in a concentration-dependent (10-50 microM) fashion.	Diterpenes	4-13	scinderin	Homo sapiens	78-87
8941400-5	1996	This study therefore extends the range of norditerpenoids, other than MLA, which can be used to probe this important class of nAChR.	Diterpenes	42-57	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	126-131
9722493-3	1998	Side chains at C-9, such as those of compounds 1-5, are frequent among the neoclerodanes found in Scutellaria species, and these transformations suggest a plausible biogenetic pathway for these diterpenoids.	Diterpenes	194-206	complement C9	Homo sapiens	15-18
9650560-1	1998	Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC).	Diterpenes	14-23	protein kinase C alpha	Homo sapiens	147-150
9322529-7	1997	Apoptosis was increased and diterpenoids caused overexpression of p53 and interleukin 1 beta-converting enzyme in rats treated with dexamethasone (cytochrome P4503A inducer).	Diterpenes	28-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	66-69
9322529-7	1997	Apoptosis was increased and diterpenoids caused overexpression of p53 and interleukin 1 beta-converting enzyme in rats treated with dexamethasone (cytochrome P4503A inducer).	Diterpenes	28-40	caspase 1	Rattus norvegicus	74-110
8925883-0	1996	Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators.	Diterpenes	6-17	protein kinase C, gamma	Rattus norvegicus	78-94
8942380-8	1996	A review of the literature revealed that Euphorbia sap contains a diterpenoid diester which exhibits antineoplastic activity in rodents.	Diterpenes	66-77	SH2 domain containing 1A	Homo sapiens	51-54
8856661-4	1996	Structural analyses of material in active fractions pointed to the saturated diterpenoid phytanic acid, which induced RXR-dependent transcription at concentrations between 4 and 64 microM.	Diterpenes	77-88	retinoid X receptor alpha	Homo sapiens	118-121
8707265-10	1996	We conclude that the furano diterpenoids of germander are activated by CYP3A into electrophilic metabolites that deplete glutathione and cytoskeleton-associated protein thiols and form plasma membrane blebs.	Diterpenes	28-40	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	71-76
33762565-0	2021	Retracted: Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways.	Diterpenes	22-33	AKT serine/threonine kinase 1	Homo sapiens	289-292
7937700-1	1994	Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments.	Diterpenes	37-46	serum amyloid A1 cluster	Homo sapiens	15-18
8466753-8	1993	Forskolin, a naturally occurring diterpene that activates adenylylcyclase, also increases VEGF mRNA content in a time-dependent manner.	Diterpenes	33-42	vascular endothelial growth factor A	Bos taurus	90-94
1483268-1	1992	Aphidicolin is a tetracyclic diterpene antibiotic which is known to inhibit the growth of eucaryotic cells by reversible binding to DNA polymerase alpha without significant effect on cell viability in most common human cell lines.	Diterpenes	29-38	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	132-152
8707265-0	1996	Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.	Diterpenes	84-96	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	100-118
7901279-2	1993	Three lines of evidence support this hypothesis: a) Taxol, a microtubule-binding diterpene, mimics the ability of LPS to induce cytokines and down-regulate receptors for TNF-alpha.	Diterpenes	81-90	tumor necrosis factor	Mus musculus	170-179
8094975-10	1993	These results indicate that the diterpenes modulate VBL sensitivity predominantly by inhibiting PGP-mediated efflux activity.	Diterpenes	32-42	ATP binding cassette subfamily B member 1	Homo sapiens	96-99
1453179-0	1992	Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx.	Diterpenes	0-9	serine/threonine/tyrosine interaction protein	Mus musculus	77-81
1364040-3	1992	The cyclic AMP accumulation produced by forskolin (a diterpene that stimulates directly the catalytic subunit of adenylate cyclase) was also inhibited by somatostatin in a dose-dependent manner.	Diterpenes	53-62	somatostatin	Rattus norvegicus	154-166
2013130-2	1991	In control rats, the diterpene forskolin and glucagon stimulated the activity of adenylate cyclase 6- to 7-fold.	Diterpenes	21-30	adenylate cyclase 6	Rattus norvegicus	81-100
30106144-0	2018	A natural ent-kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion.	Diterpenes	22-33	mitogen-activated protein kinase 3	Homo sapiens	88-94
33806909-10	2021	Additionally, the diterpenoid enhanced the activation of Bcl2 and Bcl-xL, while suppressing apoptosis marker proteins.	Diterpenes	18-29	BCL2, apoptosis regulator	Rattus norvegicus	57-61
33806909-10	2021	Additionally, the diterpenoid enhanced the activation of Bcl2 and Bcl-xL, while suppressing apoptosis marker proteins.	Diterpenes	18-29	Bcl2-like 1	Rattus norvegicus	66-72
30106144-2	2018	An ent-kaurane diterpenoid compound CRT1 (ent-18-acetoxy-7beta-hydroxy kaur-15-oxo-16-ene), mainly isolated from the Vietnamese herb Croton tonkinesis has been used in folk medicine in Vietnam for cancer treatment.	Diterpenes	15-26	hyaluronan and proteoglycan link protein 1	Homo sapiens	36-40
30106144-12	2018	These results indicated that CRT1, an ent-kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.	Diterpenes	50-61	hyaluronan and proteoglycan link protein 1	Homo sapiens	29-33
30106144-12	2018	These results indicated that CRT1, an ent-kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.	Diterpenes	50-61	mitogen-activated protein kinase 3	Homo sapiens	128-134
30106144-12	2018	These results indicated that CRT1, an ent-kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.	Diterpenes	50-61	cellular inhibitor of PP2A	Homo sapiens	135-138
34950033-2	2021	EFL2, one of diterpenoids derived from Euphorbia seeds, is nearly unknown expect for its improving effect on acute lung injury.	Diterpenes	13-25	ephrin A3	Mus musculus	0-4
34931017-3	2021	In this study we conducted human PXR (hPXR) agonistic screening using dual-luciferase reporter gene assays, which led to discovering a series of potent hPXR agonists from a small Euphorbiaceae diterpenoid library, containing 35 structurally diverse diterpenoids with eight different skeleton types.	Diterpenes	193-204	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
34931017-3	2021	In this study we conducted human PXR (hPXR) agonistic screening using dual-luciferase reporter gene assays, which led to discovering a series of potent hPXR agonists from a small Euphorbiaceae diterpenoid library, containing 35 structurally diverse diterpenoids with eight different skeleton types.	Diterpenes	193-204	nuclear receptor subfamily 1 group I member 2	Homo sapiens	38-42
34931017-3	2021	In this study we conducted human PXR (hPXR) agonistic screening using dual-luciferase reporter gene assays, which led to discovering a series of potent hPXR agonists from a small Euphorbiaceae diterpenoid library, containing 35 structurally diverse diterpenoids with eight different skeleton types.	Diterpenes	193-204	nuclear receptor subfamily 1 group I member 2	Homo sapiens	152-156
34931017-3	2021	In this study we conducted human PXR (hPXR) agonistic screening using dual-luciferase reporter gene assays, which led to discovering a series of potent hPXR agonists from a small Euphorbiaceae diterpenoid library, containing 35 structurally diverse diterpenoids with eight different skeleton types.	Diterpenes	249-261	nuclear receptor subfamily 1 group I member 2	Homo sapiens	152-156
34729030-9	2022	Conclusion: In conclusion, findings of the current study suggest that selected diterpenoids were predicted to be the significant phytonutrient-based inhibitor against SARS-CoV-2 6LU7 (Mpro).	Diterpenes	79-91	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	184-188
34656698-0	2021	Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells.	Diterpenes	8-19	peroxiredoxin 5	Homo sapiens	91-112
34742027-0	2021	Diterpenoids from Euphorbia glomerulans with potential reversal activities against P-glycoprotein-mediated multidrug resistance.	Diterpenes	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
34940679-2	2021	1 afforded 11 new diterpenoids (1-11), all of which possess a tetracyclic spongian-16-one scaffold with extensive oxidation at C-6, C-7, C-11, C-12, C-13, and/or C-20.	Diterpenes	18-30	homeobox C13	Homo sapiens	149-153
34855657-0	2021	Use of Diterpene Ginkgolides Meglumine Injection to Regulate Plasma Levels of PAI-1 and t-PA in Patients With Acute Atherosclerotic Cerebral Infarction.	Diterpenes	7-16	serpin family E member 1	Homo sapiens	78-83
34855657-0	2021	Use of Diterpene Ginkgolides Meglumine Injection to Regulate Plasma Levels of PAI-1 and t-PA in Patients With Acute Atherosclerotic Cerebral Infarction.	Diterpenes	7-16	plasminogen activator, tissue type	Homo sapiens	88-92
34855657-1	2021	BACKGROUND: To: (i) explore the effect of diterpene ginkgolides meglumine injection (DGMI) on neurological deficit symptoms in acute atherosclerotic cerebral infarction (AACI) patients; (ii) measure the level of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA).	Diterpenes	42-51	serpin family E member 1	Homo sapiens	219-258
34855657-1	2021	BACKGROUND: To: (i) explore the effect of diterpene ginkgolides meglumine injection (DGMI) on neurological deficit symptoms in acute atherosclerotic cerebral infarction (AACI) patients; (ii) measure the level of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA).	Diterpenes	42-51	plasminogen activator, tissue type	Homo sapiens	263-297
34940679-2	2021	1 afforded 11 new diterpenoids (1-11), all of which possess a tetracyclic spongian-16-one scaffold with extensive oxidation at C-6, C-7, C-11, C-12, C-13, and/or C-20.	Diterpenes	18-30	RNA polymerase III subunit K	Homo sapiens	137-141
34267886-0	2021	Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure-Activity Relationships.	Diterpenes	10-22	nuclear receptor subfamily 1 group I member 2	Homo sapiens	32-36
34319739-2	2021	While these diterpenoids share a 5/7/6-trans-fused ring system (ABC-ring), the three-carbon substitutions at the C13- and C14-positions on the C-ring and appending oxygen functional groups differ among them, accounting for the disparate biological activities of these natural products.	Diterpenes	12-24	homeobox C13	Homo sapiens	113-116
34267886-2	2021	In this study, the human PXR (hPXR) agonistic bioassay-guided isolation of Euphorbia lathyris followed by the structural modification led to the construction of a lathyrane diterpenoid library (1-34).	Diterpenes	173-184	nuclear receptor subfamily 1 group I member 2	Homo sapiens	25-28
34267886-2	2021	In this study, the human PXR (hPXR) agonistic bioassay-guided isolation of Euphorbia lathyris followed by the structural modification led to the construction of a lathyrane diterpenoid library (1-34).	Diterpenes	173-184	nuclear receptor subfamily 1 group I member 2	Homo sapiens	30-34
34267886-6	2021	These findings suggested that lathyrane diterpenoids could serve as a new type of hPXR agonist for future anticholestasis drug development.	Diterpenes	40-52	nuclear receptor subfamily 1 group I member 2	Homo sapiens	82-86
35245067-0	2022	Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects from Euphorbia helioscopia.	Diterpenes	11-23	potassium voltage-gated channel subfamily A member 3	Homo sapiens	29-34
35585772-1	2022	Bacteria, especially Streptomyces spp., have been emerging as rich sources of natural diterpenoids with diverse structures and broad bioactivities.	Diterpenes	86-98	histocompatibility minor 13	Homo sapiens	34-37
35245067-4	2022	The inhibitory effect of the isolated diterpenoids against Kv1.3 ion channels was evaluated in a human embryonic kidney 293 cell model transfected with plasmid encoding Kv1.3, resulting in the identification of a series of potent Kv1.3 ion channel inhibitors, with the most active ones (2 and 15) showing IC50 values of 0.9 muM.	Diterpenes	38-50	potassium voltage-gated channel subfamily A member 3	Homo sapiens	59-64
35245067-4	2022	The inhibitory effect of the isolated diterpenoids against Kv1.3 ion channels was evaluated in a human embryonic kidney 293 cell model transfected with plasmid encoding Kv1.3, resulting in the identification of a series of potent Kv1.3 ion channel inhibitors, with the most active ones (2 and 15) showing IC50 values of 0.9 muM.	Diterpenes	38-50	potassium voltage-gated channel subfamily A member 3	Homo sapiens	169-174
35450348-0	2022	C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.	Diterpenes	36-48	ATP binding cassette subfamily B member 1	Homo sapiens	87-101
35424922-1	2022	We report herein a highly efficient strategy for construction of a bridged oxa-(3.2.1)octane-embedded 5-7-6 tricyclic carbon skeleton through (3 + 2) IMCC (intramolecular (3 + 2) cross-cycloaddition), and the substituents and/or stereochemistries on C-4, C-6, C-7 and C-10 fully match those in the rhamnofolane, tigliane and daphnane diterpenoids.	Diterpenes	334-346	homeobox C10	Homo sapiens	268-272
35173433-4	2022	Methods: An iRGD tumor-penetrating peptide-modified nano-delivery system (denoted as iRGD-PSS@PBAE@JQ1/ORI nanoparticles) based on a marine sulfated polysaccharide was developed by codelivery of JQ1 (BET inhibitor) and oridonin (ORI, bioactive diterpenoid derived from traditional Chinese medicine herb).	Diterpenes	244-255	delta/notch like EGF repeat containing	Homo sapiens	200-203
35205173-2	2022	There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors.	Diterpenes	77-87	butyrylcholinesterase	Homo sapiens	163-177
3622760-3	1987	The OAG-induced increase of intracellular Ca2+ is not influenced by forskolin, in contrast to the effect of the diterpene on the thrombin-stimulated increase in cytoplasmic Ca2+.	Diterpenes	112-121	coagulation factor II, thrombin	Homo sapiens	129-137
35045773-0	2022	New ent-kaurene-type nor-diterpene and other compounds isolated from Annona vepretorum Mart.	Diterpenes	21-34	septin 4	Homo sapiens	87-91
35053247-2	2022	From the analysis of the docking poses, both diterpenoids were able to interact significantly with COX-2, 5-lipoxygenase (5-LO), platelet-activating factor receptor (PAFR), and mPGES-1.	Diterpenes	45-57	prostaglandin E synthase	Mus musculus	177-184
2554919-9	1989	First, stimulation by the diterpene by itself was blocked by both adenosine deaminase (ADA) and 8-PT (40 and 25% inhibition respectively).	Diterpenes	26-35	adenosine deaminase	Mus musculus	66-85
2463830-6	1988	This effect of inhibiting (or reversing) the insulin-stimulated fraction of transport is a novel effect of the diterpene.	Diterpenes	111-120	insulin	Homo sapiens	45-52
2901994-4	1988	In the current studies, we show that several beta AR antagonists with ISA (dichloroisoproterenol, pindolol, and celiprolol) stimulate cAMP accumulation five-, two-, and threefold, respectively, in S49 lymphoma cells, but only if cells are simultaneously incubated with the diterpene forskolin.	Diterpenes	273-282	adrenergic receptor, beta 1	Mus musculus	45-52
2989027-7	1985	The homologous hCG-induced desensitization and the partial heterologous one induced by forskolin suggest that more than the catalytic unit of the cyclase is required for the diterpene activation.	Diterpenes	174-183	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
3015710-4	1986	Elevated extracellular potassium, dibutyryl cyclic adenosine monophosphate, and the diterpene derivative forskolin each stimulated an increase in cholecystokinin release over a 60-min period compared to basal secretion.	Diterpenes	84-93	cholecystokinin	Canis lupus familiaris	146-161
6312897-2	1983	Forskolin was found to be a potent activator of renal adenylate cyclase in rats and chicks, and the diterpene produced a marked potentiation of the cyclic AMP response to parathyroid hormone (PTH).	Diterpenes	100-109	parathyroid hormone	Rattus norvegicus	171-190
6206645-5	1984	IFN production was enhanced by the diterpene tumor promoters, TPA and mezerein, but not by classical T-cell mitogens.	Diterpenes	35-44	interferon alpha 1	Homo sapiens	0-3
33657678-5	2021	We also created multigene constructs for stable transformation of two J. curcas cytochrome P450 genes, JcCYP726A20 and JcCYP71D495 that produce the more complex diterpenoid jolkinol C from casbene when expressed transiently with JcCAS in N. benthamiana.	Diterpenes	161-172	LOW QUALITY PROTEIN: premnaspirodiene oxygenase-like	Jatropha curcas	103-114
6757248-3	1982	Inhibition of cyc- activity was seen in 11 different membrane preparations obtained from two different strains and was observable both in the absence and presence of the strongly stimulatory diterpene forskolin.	Diterpenes	191-200	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	14-17
191063-3	1977	As shown by electron spin resonance (ESR) spectra of spin-labeled acyl-ATR, the nitroxide placed on the acyl chain interacts with the diterpene residue of the atractyloside moiety when incorporated in liposomes.	Diterpenes	134-143	spindlin 1	Homo sapiens	21-25
191063-3	1977	As shown by electron spin resonance (ESR) spectra of spin-labeled acyl-ATR, the nitroxide placed on the acyl chain interacts with the diterpene residue of the atractyloside moiety when incorporated in liposomes.	Diterpenes	134-143	spindlin 1	Homo sapiens	53-57
33335309-6	2021	PKC activating diterpenes have been shown to facilitate NSC proliferation in neurogenic niches when injected intracerebroventricularly.	Diterpenes	15-25	protein kinase C, alpha	Mus musculus	0-3
33904969-2	2021	Glaucocalyxin A (GLA) is a diterpenoid component isolated from Rabdosia japonica var.	Diterpenes	27-38	galactosidase alpha	Homo sapiens	17-20
6604057-3	1983	A positive correlation was found between the tumor-promoting activities of several plant diterpenes and their enhancing effects on the growth of SCC-1 cells.	Diterpenes	89-99	protein tyrosine phosphatase receptor type J	Homo sapiens	145-150
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Diterpenes	135-145	epidermal growth factor	Homo sapiens	186-209
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Diterpenes	135-145	epidermal growth factor	Homo sapiens	211-214
33968092-0	2021	Corrigendum: Immunomodulatory Effects of Diterpenes and Their Derivatives Through NLRP3 Inflammasome Pathway: A Review.	Diterpenes	41-51	NLR family pyrin domain containing 3	Homo sapiens	82-87
33577846-2	2021	Glaucocalyxin A (GLA), isolated from Rabdosia japonica, is a diterpenoid compound with anticancer properties.	Diterpenes	61-72	galactosidase, alpha	Mus musculus	17-20
33458815-3	2021	Intriguingly, labdane-related diterpenoid (LRD) phytoalexins in maize (Zea mays) affect drought tolerance, as indicated by the increased susceptibility of an insertion mutant of the class II diterpene cyclase ZmCPS2/An2 that initiates such biosynthesis.	Diterpenes	30-41	ent-copalyl diphosphate synthase 2, chloroplastic	Zea mays	216-219
33529962-9	2021	CONCLUSION: Therefore, the present results demonstrated that compared with other diterpenoids, tricyclic-type diterpenoids could be a targeted drug candidate for the treatment of secondary IDH1 mutant type glioblastoma through negatively regulating GLS.	Diterpenes	110-122	glutaminase	Homo sapiens	249-252
33672591-4	2021	GC-MS analysis of the ME-hex part revealed the presence of methylbenzoic acids such as sparassol and atraric acid and a diterpene with a kaurene skeleton which has never been detected before in lichen species.	Diterpenes	120-129	hematopoietically expressed homeobox	Homo sapiens	25-28
33352228-12	2021	Collectively, our study reveals that new clerodane-type diterpenoid CA suppresses LPS-induced inflammation by promoting TRAF6 degradation, suggesting that CA as the potential therapeutic candidate for the treatment of inflammation associated diseases.	Diterpenes	56-67	TNF receptor-associated factor 6	Mus musculus	120-125
33417145-0	2021	Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3beta/beta-catenin transduction pathway.	Diterpenes	17-29	AKT serine/threonine kinase 1	Homo sapiens	122-125
33417145-0	2021	Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3beta/beta-catenin transduction pathway.	Diterpenes	17-29	glycogen synthase kinase 3 alpha	Homo sapiens	126-135
33417145-0	2021	Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3beta/beta-catenin transduction pathway.	Diterpenes	17-29	catenin beta 1	Homo sapiens	136-148
33508196-1	2021	ConspectusTetracyclic diterpenoids (C20) mainly refer to the plant terpenoids bearing biogenetically related carbon skeletons derived from copalyl diphosphates (ent-CPP and syn-CPP).	Diterpenes	22-34	synemin	Homo sapiens	173-176
33578967-0	2021	Anti-Malignant Ascites Effect of Total Diterpenoids from Euphorbiae Ebracteolatae Radix Is Attributable to Alterations of Aquaporins via Inhibiting PKC Activity in the Kidney.	Diterpenes	39-51	protein kinase C, alpha	Mus musculus	148-151
33578967-9	2021	Four main diterpenoids, except compound 2, reduced AQP1 level in human kidney-2 cells.	Diterpenes	10-22	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Diterpenes	4-15	aquaporin 1	Mus musculus	38-44
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Diterpenes	4-15	protein kinase C, alpha	Mus musculus	120-123
33576206-3	2021	Andrographolide (AP1), the major constituent in the leaves of the herbaceous plant Andrographis paniculata, is a diterpenoid with reported antioxidant activity.	Diterpenes	113-124	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-20
33140855-0	2021	DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation.	Diterpenes	26-37	signal transducer and activator of transcription 3	Mus musculus	90-95
33530626-0	2021	Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells.	Diterpenes	11-22	cellular communication network factor 2	Rattus norvegicus	42-46
33140695-5	2022	Previously, it has been shown experimentally that eight diterpenoids and four biflavonoids derived from the leaf of Torreya nucifera show inhibitory effect on the cleavage/catalytic activity of the SARS CoV-1 Mpro.	Diterpenes	56-68	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	209-213
33390969-6	2020	Among all the compounds, diterpenoids is the most promising candidates for inhibiting NLRP3 inflammasome activation and improving fibrosis, as they possess combined inhibitory effect on NLRP3 inflammasome assembly and NF-kappaB signaling pathway.	Diterpenes	25-37	NLR family pyrin domain containing 3	Homo sapiens	86-91
33390969-6	2020	Among all the compounds, diterpenoids is the most promising candidates for inhibiting NLRP3 inflammasome activation and improving fibrosis, as they possess combined inhibitory effect on NLRP3 inflammasome assembly and NF-kappaB signaling pathway.	Diterpenes	25-37	NLR family pyrin domain containing 3	Homo sapiens	186-191
33291318-3	2020	In order to identify novel P2X7R antagonists, we carried out virtual screening on a focused compound dataset, including indole derivatives and natural compounds such as caffeic acid phenethyl ester derivatives, flavonoids, and diterpenoids.	Diterpenes	227-239	purinergic receptor P2X 7	Homo sapiens	27-32
33291318-4	2020	Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) rescoring and structural fingerprint clustering of docking poses from virtual screening highlighted that the diterpenoid dihydrotanshinone (DHTS) clustered with the well-known P2X7R antagonist JNJ47965567.	Diterpenes	169-180	purinergic receptor P2X 7	Homo sapiens	236-241
33197184-1	2020	The evolution of a strategy to access the family of rearranged spongian diterpenoids harboring a concave-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-one fragment is described.	Diterpenes	72-84	suppressor of cytokine signaling 2	Homo sapiens	117-122
33413289-15	2021	The diterpenes DEOX, ICT, and DAM decreased levels of NO (38.34, 47.63, 67.15%), IL-6 (57.84, 60.45, 44.26%), and TNF-alpha (38.90, 31.30, 32.83%), respectively.	Diterpenes	4-14	interleukin 6	Mus musculus	81-85
33413289-15	2021	The diterpenes DEOX, ICT, and DAM decreased levels of NO (38.34, 47.63, 67.15%), IL-6 (57.84, 60.45, 44.26%), and TNF-alpha (38.90, 31.30, 32.83%), respectively.	Diterpenes	4-14	tumor necrosis factor	Mus musculus	114-123
33413289-18	2021	Furthermore, the diterpenes DEOX, DAM, and ICT showed anti-inflammatory activity by reducing levels of NO, TNF-alpha, and IL-6.	Diterpenes	17-27	tumor necrosis factor	Mus musculus	107-116
33413289-18	2021	Furthermore, the diterpenes DEOX, DAM, and ICT showed anti-inflammatory activity by reducing levels of NO, TNF-alpha, and IL-6.	Diterpenes	17-27	interleukin 6	Mus musculus	122-126
32808003-1	2020	Covering: 2000 to 2020The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid receptor (KOR).	Diterpenes	41-50	opioid receptor kappa 1	Homo sapiens	108-129
32808003-1	2020	Covering: 2000 to 2020The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid receptor (KOR).	Diterpenes	41-50	opioid receptor kappa 1	Homo sapiens	131-134
33081023-0	2020	Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes.	Diterpenes	94-112	transient receptor potential cation channel subfamily V member 4	Homo sapiens	64-69
32855276-4	2021	First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance.	Diterpenes	85-94	fms related receptor tyrosine kinase 3	Homo sapiens	147-151
32628930-1	2020	Oridonin is a diterpene compound that regulates the activity of PPAR-gamma (peroxisome proliferator-activated receptor gamma) transcription factor.	Diterpenes	14-23	peroxisome proliferator activated receptor gamma	Mus musculus	64-74
32628930-1	2020	Oridonin is a diterpene compound that regulates the activity of PPAR-gamma (peroxisome proliferator-activated receptor gamma) transcription factor.	Diterpenes	14-23	peroxisome proliferator activated receptor gamma	Mus musculus	76-124
32888673-0	2020	Diterpenoid alkaloids from Aconitum anthoroideum that offer protection against MPP+-Induced apoptosis of SH-SY5Y cells and acetylcholinesterase inhibitory activity.	Diterpenes	0-11	M-phase phosphoprotein 6	Homo sapiens	79-82
32888673-0	2020	Diterpenoid alkaloids from Aconitum anthoroideum that offer protection against MPP+-Induced apoptosis of SH-SY5Y cells and acetylcholinesterase inhibitory activity.	Diterpenes	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
33101293-0	2020	Immunomodulatory Effects of Diterpenes and Their Derivatives Through NLRP3 Inflammasome Pathway: A Review.	Diterpenes	28-38	NLR family pyrin domain containing 3	Homo sapiens	69-74
33101293-4	2020	This review sketches a current scenario of diterpenes or their derivatives acting through NLRPs, especially NLRP3-associated pathways with anti-inflammatory effects.	Diterpenes	43-53	NLR family pyrin domain containing 3	Homo sapiens	108-113
33101293-8	2020	In conclusion, diterpenes and their derivatives could be one of the promising compounds for the treatment of NLRP3-mediated inflammatory diseases and disorders.	Diterpenes	15-25	NLR family pyrin domain containing 3	Homo sapiens	109-114
32876749-3	2020	A lipid transfer protein (NtLTP1) in tobacco showed glandular trichome-specific expression and supported the secretion of diterpenoid lipids from head cells of glandular trichomes (Choi et al., Plant J 70:480-491,2012).	Diterpenes	122-133	non-specific lipid-transfer protein 2-like	Nicotiana tabacum	26-32
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	Diterpenes	18-28	ATP binding cassette subfamily B member 1	Homo sapiens	230-244
32584575-7	2020	Analysis of IL-1beta and caspase-1 expression revealed that the new diterpenoids 15 and 18 are selective inhibitors of the NLRP3 inflammasome, reinforcing the previously demonstrated anti-inflammatory properties of hispanolone derivatives.	Diterpenes	68-80	interleukin 1 alpha	Homo sapiens	12-20
32584575-7	2020	Analysis of IL-1beta and caspase-1 expression revealed that the new diterpenoids 15 and 18 are selective inhibitors of the NLRP3 inflammasome, reinforcing the previously demonstrated anti-inflammatory properties of hispanolone derivatives.	Diterpenes	68-80	caspase 1	Homo sapiens	25-34
32584575-7	2020	Analysis of IL-1beta and caspase-1 expression revealed that the new diterpenoids 15 and 18 are selective inhibitors of the NLRP3 inflammasome, reinforcing the previously demonstrated anti-inflammatory properties of hispanolone derivatives.	Diterpenes	68-80	NLR family pyrin domain containing 3	Homo sapiens	123-128
32765254-9	2020	Furthermore, licorice saponins, yuanhua flavonoids, and di-terpenes dose/structure-dependently downregulate ZO-1 and MUC-2 protein expressions in mucosa cells.	Diterpenes	56-67	tight junction protein 1	Homo sapiens	108-112
32765254-9	2020	Furthermore, licorice saponins, yuanhua flavonoids, and di-terpenes dose/structure-dependently downregulate ZO-1 and MUC-2 protein expressions in mucosa cells.	Diterpenes	56-67	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	117-122
32020446-5	2020	Biotransformation processes were carried out and five filamentous fungi were selected as capable of producing hydroxylated diterpenes at positions C-3, C-6, C-7 and C-18 of the trans-decalin moiety and C-13 of the side chain dienic system.	Diterpenes	123-133	complement C3	Homo sapiens	147-150
32020446-5	2020	Biotransformation processes were carried out and five filamentous fungi were selected as capable of producing hydroxylated diterpenes at positions C-3, C-6, C-7 and C-18 of the trans-decalin moiety and C-13 of the side chain dienic system.	Diterpenes	123-133	complement C6	Homo sapiens	152-155
32020446-5	2020	Biotransformation processes were carried out and five filamentous fungi were selected as capable of producing hydroxylated diterpenes at positions C-3, C-6, C-7 and C-18 of the trans-decalin moiety and C-13 of the side chain dienic system.	Diterpenes	123-133	complement C7	Homo sapiens	157-160
32628479-0	2020	Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis.	Diterpenes	54-66	NLR family, pyrin domain containing 3	Mus musculus	99-104
31322002-0	2020	Diterpenes from seeds of Phalaris canariensis and their PTP1B inhibitory activity and hypoglycemic effects in streptozotocin-induced diabetic mice.	Diterpenes	0-10	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	56-61
31322002-1	2020	This present study was to evaluate the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of nine diterpenes isolated from seeds of Phalaris canariensis, as well as their effect on streptozotocin-nicotinamide-induced type 2 diabetic mice.	Diterpenes	107-117	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	72-77
31322002-3	2020	Diterpenes, 1, 4, and 2 exhibited the strongest inhibitory activity on PTP1B with IC50 values of 6.9, 7.3, and 6.5 microM, respectively, The administration of 1-9 showed significant effect on hyperglycemia, among them 1, 4, and 2 reduced fasting glucose levels (55.65%, 54.27%, and 51.22%, respectively).	Diterpenes	0-10	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	71-76
31322002-4	2020	Results revealed that diterpenes performed potential antidiabetic activity via inhibition of PTP1B.	Diterpenes	22-32	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	93-98
32310718-8	2020	Importantly, we were able to disassociate the Beinhart 1000 Phn15.1 resistance alleles from a functional NtCPS2 allele(s) which contributes to the accumulation of a diterpene leaf surface exudate considered undesirable for flue-cured and burley tobacco.	Diterpenes	165-174	copal-8-ol diphosphate hydratase, chloroplastic	Nicotiana tabacum	105-111
32223193-0	2020	Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.	Diterpenes	9-21	AKT serine/threonine kinase 1	Homo sapiens	54-57
32223193-0	2020	Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.	Diterpenes	9-21	mechanistic target of rapamycin kinase	Homo sapiens	58-62
32321920-5	2020	We have demonstrated herein that a plant derived diterpene, (EOF2; CAS number 2230806-06-9), with the capacity to activate PKC facilitates the release of neuregulin 1, and promotes neuroblasts differentiation and survival in cultures of subventricular zone (SVZ) isolated cells in a novel PKC dependent manner.	Diterpenes	49-58	neuregulin 1	Homo sapiens	154-166
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	Diterpenes	95-105	ATP binding cassette subfamily B member 1	Homo sapiens	230-244
31454650-1	2019	BACKGROUND: Euphorbia factor L1 (EFL1), a lathyrane-type diterpenoid from the medicinal herb Euphorbia lathyris L. (Euphorbiaceae), has been reported for many decades to induce gastric irritation, but the underlying mechanisms remain unclear.	Diterpenes	57-68	elongation factor like GTPase 1	Homo sapiens	33-37
32308365-0	2020	Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways.	Diterpenes	0-9	neurotrophin 3	Rattus norvegicus	65-68
32308365-0	2020	Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways.	Diterpenes	0-9	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	69-73
31678414-0	2020	Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-kappaB pathway in rats.	Diterpenes	7-25	toll-like receptor 4	Rattus norvegicus	112-116
31960210-0	2020	A diterpene derivative enhanced insulin signaling induced by high glucose level in HepG2 cells.	Diterpenes	2-11	insulin	Homo sapiens	32-39
32537993-1	2020	We investigated the signal relationship between phospholipase Dalpha1 (PLDalpha1) and the gas signal molecule hydrogen sulfide (H2S) in Arabidopsis thaliana response to the allelopathy of diterpenoid oridonin.	Diterpenes	188-199	DA1	Arabidopsis thaliana	62-69
32537993-1	2020	We investigated the signal relationship between phospholipase Dalpha1 (PLDalpha1) and the gas signal molecule hydrogen sulfide (H2S) in Arabidopsis thaliana response to the allelopathy of diterpenoid oridonin.	Diterpenes	188-199	phospholipase D alpha 1	Arabidopsis thaliana	71-80
32085637-0	2020	A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet.	Diterpenes	2-13	CD36 molecule	Mus musculus	144-147
31789406-2	2020	This study aimed to investigate the effects of Oridonin (ORI, a diterpenoid compound) on gamma-globin expression in human erythroid precursor cells and the potential underlying mechanisms.	Diterpenes	64-75	hemoglobin subunit gamma 1	Homo sapiens	89-101
30896265-1	2019	Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities.	Diterpenes	28-39	galactosidase alpha	Homo sapiens	17-20
32237357-0	2019	[Diterpenoids as PPARgamma agonists from Siegesbeckia pubescens and their anti-inflammatory effects in vitro].	Diterpenes	1-13	peroxisome proliferator activated receptor gamma	Homo sapiens	17-26
32237357-16	2019	In conclusion,the diterpenoids 1-5 isolated from S. pubescens have the PPARgamma activation activities and potential effects of anti-UC in vitro.	Diterpenes	18-30	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
31430510-0	2019	Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury.	Diterpenes	20-31	nerve growth factor	Rattus norvegicus	43-46
31485631-3	2019	Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in traditional Chinese medicine, Danshen (Salvia sp.).	Diterpenes	30-41	ATPase, class II, type 9A	Mus musculus	11-14
31485631-3	2019	Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in traditional Chinese medicine, Danshen (Salvia sp.).	Diterpenes	30-41	ATPase, class II, type 9A	Mus musculus	20-23
31845175-1	2020	Tanshinone IIA (TSA), an important natural lipophilic diterpene compound from the traditional Chinese herb Salvia miltiorrhiza Bunge, has long been widely used for the prevention and treatment of various diseases because of its anti-inflammatory activities; however, the anti-inflammatory mechanism remains unknown.	Diterpenes	54-63	ATPase, class II, type 9A	Mus musculus	11-14
31432578-0	2019	6-Methylenebicyclo[3.2.1]oct-1-en-3-one: Twisted Olefin as Diels-Alder Dienophile for Expedited Syntheses of Four Kaurane Diterpenoids.	Diterpenes	122-134	solute carrier family 22 member 1	Homo sapiens	25-30
31633697-7	2019	Using the group of maize (Zea mays) dolabralexin diterpenoids as an example, we highlight how modular combinations of diterpene synthase (diTPS) and cytochrome P450 monooxygenase (P450) enzymes can be used to generate different diterpenoid scaffolds.	Diterpenes	118-127	hydroperoxide lyase 1	Zea mays	149-184
30739823-3	2019	Recently, a number of new grayanane diterpenoids with unprecedented carbon skeletons have been obtained from plants of the Ericaceae family, and they exhibit diverse biological properties, such as agalgesic, antinociceptive, anticancer, antiviral, antifeedant, insecticidal, toxicity, and PTP1B.	Diterpenes	36-48	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	289-294
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	complement C3	Homo sapiens	192-195
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	complement C4A (Rodgers blood group)	Homo sapiens	197-200
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	complement C5	Homo sapiens	202-205
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	complement C9	Homo sapiens	207-210
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	homeobox C13	Homo sapiens	212-216
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	complement C9	Homo sapiens	320-323
31086098-1	2019	Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14.	Diterpenes	17-29	homeobox C13	Homo sapiens	325-329
30733060-0	2019	Cytochrome P450 enzymes: A driving force of plant diterpene diversity.	Diterpenes	50-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
31468670-0	2019	An ent-Kaurane Diterpenoid Isolated from Rabdosia excisa Suppresses Bcr-Abl Protein Expression in Vitro and in Vivo and Induces Apoptosis of CML Cells.	Diterpenes	15-26	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	68-75
31167117-0	2019	Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.	Diterpenes	6-17	kelch like ECH associated protein 1	Homo sapiens	41-46
31167117-0	2019	Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.	Diterpenes	6-17	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
31167117-5	2019	Sixteen diterpenoids were found to be novel potential activators of Nrf2-mediated defensive response.	Diterpenes	8-20	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
31167117-6	2019	Of which, an isopimarane-type diterpenoid, sphaeropsidin A (SA), was identified as a potent activator of the Keap1/Nrf2/ARE pathway, and displayed approximately 5-folds potency than that of sulforaphane (SF).	Diterpenes	30-41	kelch like ECH associated protein 1	Homo sapiens	109-114
31167117-6	2019	Of which, an isopimarane-type diterpenoid, sphaeropsidin A (SA), was identified as a potent activator of the Keap1/Nrf2/ARE pathway, and displayed approximately 5-folds potency than that of sulforaphane (SF).	Diterpenes	30-41	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
31291107-2	2019	Herein, we report the in vivo, in vitro, and structural characterizations of a nonheme diiron monooxygenase, PtmU3, that installs a C-5 beta-hydroxyl group in the unified biosynthesis of platensimycin and platencin, two highly functionalized diterpenoids that act as potent and selective inhibitors of bacterial and mammalian fatty acid synthases.	Diterpenes	242-254	complement C5	Homo sapiens	132-140
31234546-5	2019	Notably, several diterpenoid alkaloids were more potent against MDR subline KB-VIN cells than the parental drug-sensitive KB cells.	Diterpenes	17-28	long intergenic non-protein coding RNA 1191	Homo sapiens	79-82
30900700-2	2019	Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions.	Diterpenes	87-99	complement C3	Homo sapiens	133-136
30900700-2	2019	Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions.	Diterpenes	87-99	complement C6	Homo sapiens	138-141
30900700-2	2019	Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions.	Diterpenes	87-99	complement C7	Homo sapiens	143-146
30900700-2	2019	Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions.	Diterpenes	87-99	RNA polymerase III subunit K	Homo sapiens	148-152
30900700-2	2019	Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions.	Diterpenes	87-99	placenta associated 8	Homo sapiens	157-161
30949480-9	2019	Diterpenes with 12-deoxyphorbol or lathyrane skeleton, increase NPC proliferation in neurogenic niches in the adult mouse brain in a PKCbeta dependent manner exerting their effects on transit amplifying cells, whereas PKC inhibition in injuries promotes neurogenesis.	Diterpenes	0-10	protein kinase C, beta	Mus musculus	133-140
30745855-2	2019	Here, we identified Andrographolide, a diterpenoid lactone derived from a traditional herbal medicine Andrographis paniculata, as an ideal sensitizer for TRAIL to overcome bladder cancer.	Diterpenes	39-50	TNF superfamily member 10	Homo sapiens	154-159
30553829-0	2019	Three new capnosane-type diterpenoids from the South China Sea soft coral Lobophytum sp.	Diterpenes	25-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	59-62
30576973-1	2019	Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin.	Diterpenes	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	167-172
30741932-0	2019	Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis.	Diterpenes	18-29	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	60-65
30741932-3	2019	Through high content screens of a library of chemicals isolated from medicinal plants in China for inhibitors of a Fli-1 transcriptional reporter cells, we hereby report the identification of diterpenoid-like compounds that strongly inhibit Fli-1 transcriptional activity.	Diterpenes	192-203	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	115-120
30741932-3	2019	Through high content screens of a library of chemicals isolated from medicinal plants in China for inhibitors of a Fli-1 transcriptional reporter cells, we hereby report the identification of diterpenoid-like compounds that strongly inhibit Fli-1 transcriptional activity.	Diterpenes	192-203	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	241-246
30741932-7	2019	Computational docking analysis revealed that the diterpenoid-like compounds bind with high affinity to nucleotide residues in a pocket near the major groove within the DNA-binding sites of Fli-1.	Diterpenes	49-60	Friend leukemia integration 1	Mus musculus	189-194
30654553-6	2019	They differ in their stereochemistry, since these diterpenes are characterized by a trans ring fusion at the decalin moiety and the relative configuration of the two methyl groups at C-8 and C-9 in a cis relationship (type trans/cis).	Diterpenes	50-60	homeobox C8	Homo sapiens	183-194
30662405-6	2018	UbiA prenyltransferase domain-containing protein-1 regulates the ubiquitination and proteasome-mediated degradation of HMGCR, which is accelerated by 24, 25-dihydrolanosterol and the diterpene geranylgeraniol.	Diterpenes	183-192	UbiA prenyltransferase domain containing 1	Mus musculus	0-50
30662405-6	2018	UbiA prenyltransferase domain-containing protein-1 regulates the ubiquitination and proteasome-mediated degradation of HMGCR, which is accelerated by 24, 25-dihydrolanosterol and the diterpene geranylgeraniol.	Diterpenes	183-192	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	119-124
30599895-0	2019	Andrographis paniculata diterpenoids and ethanolic extract inhibit TNFalpha-induced ICAM-1 expression in EA.hy926 cells.	Diterpenes	24-36	tumor necrosis factor	Homo sapiens	67-75
30599895-0	2019	Andrographis paniculata diterpenoids and ethanolic extract inhibit TNFalpha-induced ICAM-1 expression in EA.hy926 cells.	Diterpenes	24-36	intercellular adhesion molecule 1	Homo sapiens	84-90
30251663-11	2018	Finally, the diterpenoid induced the expression of tumor suppressor lncRNAs (MEG-3, GAS-5), while down-regulating oncogenic H19 expression.	Diterpenes	13-24	maternally expressed 3	Homo sapiens	77-82
29644528-0	2018	A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway.	Diterpenes	24-35	tumor protein p53	Homo sapiens	200-203
30114517-8	2018	Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay.	Diterpenes	128-138	interleukin 1 beta	Mus musculus	79-87
30114517-8	2018	Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay.	Diterpenes	128-138	interleukin 6	Mus musculus	89-93
30114517-8	2018	Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay.	Diterpenes	128-138	tumor necrosis factor	Mus musculus	98-107
30613338-4	2018	Our study presents abietane-type diterpenoids as an attractive starting point for the design of selective ABHD16A inhibitors, which will contribute toward understanding the significance of hABHD16A inhibition in vivo.	Diterpenes	33-45	abhydrolase domain containing 16A, phospholipase	Homo sapiens	106-113
30613338-4	2018	Our study presents abietane-type diterpenoids as an attractive starting point for the design of selective ABHD16A inhibitors, which will contribute toward understanding the significance of hABHD16A inhibition in vivo.	Diterpenes	33-45	abhydrolase domain containing 16A, phospholipase	Homo sapiens	189-197
30340898-0	2018	Semisynthesis of ent-norstrobane diterpenoids as potential inhibitor for factor Xa.	Diterpenes	33-45	coagulation factor X	Homo sapiens	73-82
30251663-11	2018	Finally, the diterpenoid induced the expression of tumor suppressor lncRNAs (MEG-3, GAS-5), while down-regulating oncogenic H19 expression.	Diterpenes	13-24	growth arrest specific 5	Homo sapiens	84-89
30443546-11	2018	Furthermore, we showed that the concurrent dynamic control of ERG20 and ERG9 expression, using ergosterol and carbon source regulation mechanisms, could substantially improve diterpene titer.	Diterpenes	175-184	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	62-67
30443546-11	2018	Furthermore, we showed that the concurrent dynamic control of ERG20 and ERG9 expression, using ergosterol and carbon source regulation mechanisms, could substantially improve diterpene titer.	Diterpenes	175-184	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	72-76
30405674-6	2018	ZmAN1 is essential for gibberellin phytohormone biosynthesis, whereas ZmAN2 is stress-inducible and governs the formation of defensive kauralexin and dolabralexin diterpenoids.	Diterpenes	163-175	ent-copalyl diphosphate synthase 2, chloroplastic	Zea mays	70-75
29130687-1	2018	The development of a convergent fragment coupling strategy for the enantioselective total syntheses of a group of rearranged spongian diterpenoids that harbor the cis-2,8-dioxabicyclo[3.3.0]octan-3-one unit is described.	Diterpenes	134-146	suppressor of cytokine signaling 2	Homo sapiens	163-168
30199257-2	2018	Aiming at obtaining compounds with improved multidrug-resistance (MDR) reversal activity, compound 8, an ent-abietane diterpene, was derivatized by introducing nitrogen-containing and aromatic moieties, yielding compounds 9-14.	Diterpenes	118-127	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	66-69
30429953-0	2018	Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents.	Diterpenes	33-44	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	62-67
30030474-0	2018	Coactivation of MEP-biosynthetic genes and accumulation of abietane diterpenes in Salvia sclarea by heterologous expression of WRKY and MYC2 transcription factors.	Diterpenes	68-78	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	136-140
30425290-4	2018	The ability of oridonin to target Nucleolin and/or HSP70 could account for the bioactivity profile of this plant diterpene.	Diterpenes	113-122	nucleolin	Homo sapiens	34-43
30425290-4	2018	The ability of oridonin to target Nucleolin and/or HSP70 could account for the bioactivity profile of this plant diterpene.	Diterpenes	113-122	heat shock protein family A (Hsp70) member 4	Homo sapiens	51-56
30061613-5	2018	Here, we demonstrate the benefits of a collaborative study of the phomactins, diterpenoid fungal metabolites that serve as antagonists of the platelet activating factor receptor.	Diterpenes	78-89	platelet activating factor receptor	Homo sapiens	142-177
30157785-12	2018	Results of microarray analysis of B16 cells treated with daphnane diterpenoid gnidilatidin from TH revealed an upregulation of tumor suppressor Egr1 while inhibiting metastasis-associated genes Id2 and Sytl2 expression.	Diterpenes	66-77	early growth response 1	Mus musculus	144-148
30157785-12	2018	Results of microarray analysis of B16 cells treated with daphnane diterpenoid gnidilatidin from TH revealed an upregulation of tumor suppressor Egr1 while inhibiting metastasis-associated genes Id2 and Sytl2 expression.	Diterpenes	66-77	inhibitor of DNA binding 2	Mus musculus	194-197
30157785-12	2018	Results of microarray analysis of B16 cells treated with daphnane diterpenoid gnidilatidin from TH revealed an upregulation of tumor suppressor Egr1 while inhibiting metastasis-associated genes Id2 and Sytl2 expression.	Diterpenes	66-77	synaptotagmin-like 2	Mus musculus	202-207
30106289-4	2018	The cytotoxicity of the diterpenoids was evaluated using RKO and LOVO colon cancer cells in which regenerating islet-derived protein 3-alpha (Reg3A) is highly expressed.	Diterpenes	24-36	regenerating family member 3 alpha	Homo sapiens	98-140
30106289-4	2018	The cytotoxicity of the diterpenoids was evaluated using RKO and LOVO colon cancer cells in which regenerating islet-derived protein 3-alpha (Reg3A) is highly expressed.	Diterpenes	24-36	regenerating family member 3 alpha	Homo sapiens	142-147
29542683-0	2018	Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.	Diterpenes	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	97-101
29542683-0	2018	Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.	Diterpenes	0-9	cAMP responsive element binding protein 1	Rattus norvegicus	106-110
29542683-0	2018	Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.	Diterpenes	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
28084806-8	2018	In short-term controlled studies, consumption of coffee, or coffee diterpenes was associated with either a reduction in serum Lp(a) of <=11 mg/dL (6 trials, 275 participants), or no effect (2 trials, 56 participants).	Diterpenes	67-77	lipoprotein(a)	Homo sapiens	126-131
30013348-0	2018	Ginkgo biloba extract and its diterpene ginkgolide constituents ameliorate the metabolic disturbances caused by recombinant tissue plasminogen activator in rat prefrontal cortex.	Diterpenes	30-39	plasminogen activator, tissue type	Rattus norvegicus	124-152
29873321-0	2018	Natural Diterpenoid Isoferritin A (IsoA) Inhibits Glioma Cell Growth and Metastasis via Regulating of TGFbeta-Induced EMT Signal Pathway.	Diterpenes	8-19	transforming growth factor, beta 1	Mus musculus	102-109
29679904-2	2018	Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae).	Diterpenes	48-59	ATPase, class II, type 9A	Mus musculus	11-14
29679904-2	2018	Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae).	Diterpenes	48-59	ATPase, class II, type 9A	Mus musculus	20-23
29641985-0	2018	LC-MS guided isolation of diterpenoids from Sapium insigne with alpha-glucosidase inhibitory activities.	Diterpenes	26-38	sucrase-isomaltase	Homo sapiens	64-81
29641985-6	2018	The preliminary structure-activity relationships of the ent-atisane diterpenoids inhibiting alpha-glucosidase were discussed.	Diterpenes	68-80	sucrase-isomaltase	Homo sapiens	92-109
30358211-0	2018	Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway.	Diterpenes	11-22	mechanistic target of rapamycin kinase	Homo sapiens	215-219
30358211-0	2018	Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway.	Diterpenes	11-22	AKT serine/threonine kinase 1	Homo sapiens	225-228
29873321-0	2018	Natural Diterpenoid Isoferritin A (IsoA) Inhibits Glioma Cell Growth and Metastasis via Regulating of TGFbeta-Induced EMT Signal Pathway.	Diterpenes	8-19	IL2 inducible T cell kinase	Mus musculus	118-121
29692986-10	2018	Both ACS mutants generated the diterpene macrocycle syn-copalol and a minor, non-hydroxylated labdane related diterpene, respectively.	Diterpenes	31-40	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	5-8
29680963-4	2018	The anti-inflammatory and anti-angiogenic activities of eight diterpenoids were evaluated on LPS-induced macrophage RAW264.7 cells and TNF-alpha-stimulated human umbilical vein endothelial cells (HUVECs) using hierarchical cluster analysis (HCA) and principal component analysis (PCA).	Diterpenes	62-74	tumor necrosis factor	Mus musculus	135-144
29680963-6	2018	All the eight diterpenes significantly down-regulated the excessive secretion of TNF-alpha, IL-6, IL-1beta and NO in LPS-induced RAW264.7 macrophages.	Diterpenes	14-24	tumor necrosis factor	Mus musculus	81-90
29680963-10	2018	In conclusion, eight diterpenes isolated from D. genkwa showed different levels of activity in LPS-induced RAW264.7 cells and TNF-alpha-stimulated HUVECs.	Diterpenes	21-31	tumor necrosis factor	Mus musculus	126-135
29522264-2	2018	Recently, the diterpene (+)-larixol and its acetylated congeners demonstrated selective inhibition of the second-messenger-gated cation channel transient receptor potential canonical 6 (TRPC6) over its close isoforms TRPC3 and TRPC7.	Diterpenes	14-23	transient receptor potential cation channel subfamily C member 6	Homo sapiens	186-191
29522264-2	2018	Recently, the diterpene (+)-larixol and its acetylated congeners demonstrated selective inhibition of the second-messenger-gated cation channel transient receptor potential canonical 6 (TRPC6) over its close isoforms TRPC3 and TRPC7.	Diterpenes	14-23	transient receptor potential cation channel subfamily C member 3	Homo sapiens	217-222
29522264-2	2018	Recently, the diterpene (+)-larixol and its acetylated congeners demonstrated selective inhibition of the second-messenger-gated cation channel transient receptor potential canonical 6 (TRPC6) over its close isoforms TRPC3 and TRPC7.	Diterpenes	14-23	transient receptor potential cation channel subfamily C member 7	Homo sapiens	227-232
29651531-1	2018	Studies have documented the potential antitumor activities of glaucocalyxin A (GLA), an ent-kaurene diterpenoid isolated from Rabdosia japonica.	Diterpenes	100-111	galactosidase alpha	Homo sapiens	62-77
29651531-1	2018	Studies have documented the potential antitumor activities of glaucocalyxin A (GLA), an ent-kaurene diterpenoid isolated from Rabdosia japonica.	Diterpenes	100-111	galactosidase alpha	Homo sapiens	79-82
29635906-2	2018	Here, we studied anti-inflammatory effects of a major diterpenoid named trigonoreidon B (TR-B) isolated from T. reidioides roots in lipopolysaccharide (LPS)-activated RAW264.7 macrophages and D-galactosamine (D-GalN)/LPS-induced inflammatory liver injury in mice.	Diterpenes	54-65	apoptosis antagonizing transcription factor	Mus musculus	89-93
29573634-0	2018	Human serum albumin binding to the biologically active labdane diterpene "leoheterin": Spectroscopic and in silico analysis.	Diterpenes	63-72	albumin	Homo sapiens	12-19
29761098-6	2018	The IC50 values of compounds 2a, a diterpene bearing polycyclic skeleton, and 3a, named daphneone with chain scaffold, are as low as 1.29 and 1.79 muM, respectively.	Diterpenes	35-44	latexin	Homo sapiens	147-150
29692986-10	2018	Both ACS mutants generated the diterpene macrocycle syn-copalol and a minor, non-hydroxylated labdane related diterpene, respectively.	Diterpenes	110-119	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	5-8
29660932-6	2018	Additionally, assays using Abeta peptide demonstrated that diterpenes, particularly ferruginol, restore LTP and reduce apoptosis.	Diterpenes	59-69	amyloid beta (A4) precursor protein	Mus musculus	27-32
29262311-5	2018	In addition, we demonstrated an apoptotic response after treatment of cancer cells with this semisynthetic phenolic labdane diterpene at 6.25 and 12.5muM concentrations that probably involves the reduction of Hsp70 expression and reactive oxygen species production.	Diterpenes	124-133	heat shock protein family A (Hsp70) member 4	Homo sapiens	209-214
29246853-0	2018	Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells.	Diterpenes	19-28	urotensin 2	Homo sapiens	39-51
29246853-0	2018	Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells.	Diterpenes	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
28611470-4	2018	As the ACE-ring 4a possesses the correct C4,11-quaternary and C10-tertiary carbons, 4a would serve as an advanced intermediate for constructing the entire C19-diterpene alkaloid structures.	Diterpenes	159-168	angiotensin I converting enzyme	Homo sapiens	7-10
28611470-4	2018	As the ACE-ring 4a possesses the correct C4,11-quaternary and C10-tertiary carbons, 4a would serve as an advanced intermediate for constructing the entire C19-diterpene alkaloid structures.	Diterpenes	159-168	homeobox C10	Homo sapiens	62-65
29253734-0	2018	Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2.	Diterpenes	0-12	carboxylesterase 2	Homo sapiens	92-110
29091322-0	2018	A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IkappaBalpha-Mediated p65 Nuclear Translocation.	Diterpenes	8-19	interferon-related developmental regulator 1	Mus musculus	90-95
29091322-0	2018	A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IkappaBalpha-Mediated p65 Nuclear Translocation.	Diterpenes	8-19	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	109-121
29091322-0	2018	A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IkappaBalpha-Mediated p65 Nuclear Translocation.	Diterpenes	8-19	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	131-134
29900223-5	2018	We used two genes including GGPPS (Geranylgeranyl diphospate synthase), which is responsible for the formation of common diterpenoid precursor (GGPP) and CS (Casbene Synthase), which functions in the synthesis of casbene.	Diterpenes	121-132	geranylgeranyl pyrophosphate synthase, chloroplastic-like	Jatropha curcas	28-33
29900223-5	2018	We used two genes including GGPPS (Geranylgeranyl diphospate synthase), which is responsible for the formation of common diterpenoid precursor (GGPP) and CS (Casbene Synthase), which functions in the synthesis of casbene.	Diterpenes	121-132	geranylgeranyl pyrophosphate synthase, chloroplastic-like	Jatropha curcas	35-69
29407947-0	2018	Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance.	Diterpenes	11-23	ATP binding cassette subfamily B member 1	Homo sapiens	76-90
29660932-9	2018	Our results suggest a potential neuroprotective role for diterpenes against the Abeta oligomers-induced neurodegenerative alterations, which make them interesting molecules to be further studied in the context of AD.	Diterpenes	57-67	amyloid beta (A4) precursor protein	Mus musculus	80-85
28934646-0	2017	Clerodane diterpenoids from Scutellaria formosana with inhibitory effects on NO production and interactions with iNOS protein.	Diterpenes	10-22	nitric oxide synthase 2, inducible	Mus musculus	113-117
28774817-3	2017	This study shows that euphorbia factor L1 (EFL1), a diterpenoid isolated from Euphorbia lathyris, inhibited osteoclastogenesis and induced osteoclast apoptosis.	Diterpenes	52-63	elongation factor like GTPase 1	Mus musculus	43-47
28858498-1	2017	The secondary metabolites that comprise the diterpenoid alkaloids are categorized into C18, C19, and C20 families depending on the number of contiguous carbon atoms that constitute their central framework.	Diterpenes	44-55	Bardet-Biedl syndrome 9	Homo sapiens	87-90
28651465-13	2017	Analysis of apoptosis-related proteins revealed that lathyrane diterpene triggered the mitochondrion-mediated apoptosis pathway, which led to the loss of mitochondrial membrane potential (DeltaPsim) and activation of caspase-6.	Diterpenes	63-72	caspase 6	Homo sapiens	217-226
28789798-9	2017	The diterpenes ent-kaurenoic acid 1, ent-polyalthic acid 3, ent-copalic acid 5 and, ent-3-beta-acetoxy copalic acid 9 were found with more frequency in COR analyzed samples.	Diterpenes	4-14	mediator complex subunit 25	Homo sapiens	29-35
28789798-9	2017	The diterpenes ent-kaurenoic acid 1, ent-polyalthic acid 3, ent-copalic acid 5 and, ent-3-beta-acetoxy copalic acid 9 were found with more frequency in COR analyzed samples.	Diterpenes	4-14	solute carrier family 29 member 3	Homo sapiens	84-89
28972149-0	2017	Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses.	Diterpenes	71-81	pleiotropic drug resistance protein 1	Nicotiana tabacum	47-53
28972149-2	2017	NtPDR1 from Nicotiana tabacum has been shown to be involved in the constitutive defense against pathogens through the secretion of toxic cyclic diterpenes, such as the antimicrobial substrates cembrene and sclareol from the leaf hairs (trichomes).	Diterpenes	144-154	pleiotropic drug resistance protein 1	Nicotiana tabacum	0-6
28972149-10	2017	In conclusion, we provide direct evidence of an interaction between the NtPDR1 transporter and its substrates and that NtPDR1 transports compounds involved in both constitutive (diterpenes) and induced (sesquiterpenes) plant defenses.	Diterpenes	178-188	pleiotropic drug resistance protein 1	Nicotiana tabacum	72-78
28972149-10	2017	In conclusion, we provide direct evidence of an interaction between the NtPDR1 transporter and its substrates and that NtPDR1 transports compounds involved in both constitutive (diterpenes) and induced (sesquiterpenes) plant defenses.	Diterpenes	178-188	pleiotropic drug resistance protein 1	Nicotiana tabacum	119-125
29041773-1	2017	Resiniferatoxin (1) belongs to a daphnane diterpenoid family and has strong agonistic effects on TRPV1, a transducer of noxious temperature and chemical stimuli.	Diterpenes	42-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
29137334-0	2017	The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression.	Diterpenes	11-20	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	126-131
29137334-0	2017	The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression.	Diterpenes	11-20	CASP8 and FADD like apoptosis regulator	Homo sapiens	136-142