PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2665936-0	1989	[What is the reason for the increase in beta-2-microglobulin levels in the blood when using cuprophane dialysis membranes?].	cuprammonium cellulose	92-102	beta-2-microglobulin	Homo sapiens	40-60
2611049-6	1989	The LAL-RM and C3a levels rose significantly in the 16 patients while on dialysis with cuprophan membranes, but there was no correlation between the LAL-RM and C3a levels.	cuprammonium cellulose	87-96	complement C3	Homo sapiens	15-18
2528653-6	1989	In contrast, the functionally active form of C3 (C3b) was a prominent constituent of the cuprophan eluate.	cuprammonium cellulose	89-98	complement C3	Homo sapiens	45-47
2528653-6	1989	In contrast, the functionally active form of C3 (C3b) was a prominent constituent of the cuprophan eluate.	cuprammonium cellulose	89-98	complement C3	Homo sapiens	49-52
2528653-10	1989	These studies demonstrate that a portion of the C3b molecules that bind to cuprophan are protected from degradation, and suggest that the complement activating capacity of hemodialysis membranes is determined by biochemical properties that modulate both the binding of serum proteins to the membrane and the interactions of the endogenous regulatory proteins with membrane-associated C3b.	cuprammonium cellulose	75-84	complement C3	Homo sapiens	48-51
2788763-2	1989	In patients dialyzed with new hollow-fiber cuprophane dialyzers, predialytic (T0) monocyte-associated IL-1 activity was 12.5 +/- 3.0 U/ml (mean +/- SEM), a value that was higher than that found in normal individuals (2.85 +/- 0.85 U/ml; P less than 0.0025) and in non-dialyzed patients with chronic renal failure (0.95 +/- 0.85 U/ml, P less than 0.0001).	cuprammonium cellulose	43-53	interleukin 1 alpha	Homo sapiens	102-106
2788763-3	1989	Cell-associated IL-1 activity was consistently increased after five hours of dialysis with cuprophane membranes (42.4 +/- 5.5 U/ml, P less than 0.0005).	cuprammonium cellulose	91-101	interleukin 1 alpha	Homo sapiens	16-20
2509378-0	1989	Red blood cell function and beta 2 microglobulin kinetics during cuprophan hemodialysis: a hypothesis.	cuprammonium cellulose	65-74	beta-2-microglobulin	Homo sapiens	28-48
2665936-1	1989	The authors discuss the question of whether the growing blood concentration of beta-2-microglobulin in the course of haemodialysis is due to the bioincompatibility of the cuprophane membrane or to changes in serum osmolality.	cuprammonium cellulose	171-181	beta-2-microglobulin	Homo sapiens	79-99
2722277-8	1989	It is possible that the minor biocompatibility of the cuprophan membrane of dialyzers is the most significant factor responsible for the hyperproduction of B2-m and thus of the osteo-articular deposition of a new type of amyloidosis.	cuprammonium cellulose	54-63	beta-2-microglobulin	Homo sapiens	156-160
2655913-6	1989	Since beta-2-microglobulin is not normally removed in routine cuprophane haemodialysis, its blood values keep increasing.	cuprammonium cellulose	62-72	beta-2-microglobulin	Homo sapiens	6-26
2646507-7	1989	In acute studies, beta 2M clearance during hemodialysis was markedly increased using the Fresenius polysulfone dialyzers compared to cuprophane dialyzers.	cuprammonium cellulose	133-143	beta-2-microglobulin	Homo sapiens	18-25
2651325-8	1989	Sieving coefficients for beta 2-microglobulin (beta 2-m) were virtually zero with classical Cuprophan and 0.66 with high-flux cellulose acetate membranes.	cuprammonium cellulose	92-101	beta-2-microglobulin	Homo sapiens	25-45
3055992-6	1988	Polymethylmethacrylate 2.0 m2, cuprophane and cellulose acetate dialyzers led to increasing beta 2m levels during dialysis, which was in excess of what could be accounted for by hemoconcentration.	cuprammonium cellulose	31-41	beta-2-microglobulin	Homo sapiens	92-99
2611000-2	1989	We used an experimental dialysis model to evaluate, by chemiluminescence, the production of reactive oxygen metabolites and, by C3a, complement activation induced by cuprophan, cellulose acetate, hemophan, polysulfone, polyacrylonitrile, polymethylmethacrylate or polyvinyl chloride blood lines alone.	cuprammonium cellulose	166-175	complement C3	Homo sapiens	128-131
2611000-4	1989	The time course of C3a levels up to 120 min showed a marked rise with cuprophan and cellulose acetate, a moderate increase with hemophan, polysulfone and blood line, and a decrease with polymethylmethacrylate and polyacrylonitrile.	cuprammonium cellulose	70-79	complement C3	Homo sapiens	19-22
2530429-8	1989	This membrane binds only a third of the amount of C3b that a cuprophan membrane will bind.	cuprammonium cellulose	61-70	complement C3	Homo sapiens	50-53
2507977-1	1989	Conflicting results have been published concerning serum beta 2 microglobulin (beta 2-M) kinetics during dialysis with a cuprophane membrane which is not permeable for the protein.	cuprammonium cellulose	121-131	beta-2-microglobulin	Homo sapiens	57-77
2507977-1	1989	Conflicting results have been published concerning serum beta 2 microglobulin (beta 2-M) kinetics during dialysis with a cuprophane membrane which is not permeable for the protein.	cuprammonium cellulose	121-131	beta-2-microglobulin	Homo sapiens	79-87
2507980-7	1989	Extracts from steam-autoclaved, dry-stored, or gamma-sterilised, wet-stored cuprophan and hemophan modules resulted in interleukin-1 activity that did not differ from negative controls.	cuprammonium cellulose	76-85	interleukin 1 alpha	Homo sapiens	119-132
2507980-8	1989	By contrast, extracts from cuprophan caused significant interleukin-1 production when prepared from ethylene oxide-sterilised, dry-stored dialysers.	cuprammonium cellulose	27-36	interleukin 1 alpha	Homo sapiens	56-69
3058172-4	1988	beta 2m plasma levels were measured in six patients during 12 Cuprophan (Cu) and 12 Eval (E) non-consecutive hemodialysis sessions without ultrafiltration.	cuprammonium cellulose	62-71	beta-2-microglobulin	Homo sapiens	0-7
3058172-6	1988	beta 2m plasma levels significantly increased with Cu but not with E. A total of 200 ml of blood from four other patients was recirculated ex vivo before Cu hemodialysis in Cu or E and then reinfused into the patient.	cuprammonium cellulose	51-53	beta-2-microglobulin	Homo sapiens	0-7
3058172-9	1988	In conclusion, 1) beta 2m plasma levels change during Cu, but are not associated with hemoconcentration from ultrafiltration nor with local release from the blood leaving the filter, 2) beta 2m binding to the membrane may account for decreased levels in recirculated blood, 3) E membranes both with and without heparin do not increase beta 2m plasma levels and reinfusion of recirculated blood blunts the beta 2m changes observed with Cu.	cuprammonium cellulose	54-56	beta-2-microglobulin	Homo sapiens	18-25
3058174-4	1988	P-alb, P-beta 2m and P-cC increased by 11.4 +/- 14.8%, 15.4 +/- 11.5%, and 22.1 +/- 14.3%, respectively, during Cuprophan dialysis.	cuprammonium cellulose	112-121	crystallin gamma D	Homo sapiens	21-25
3058174-10	1988	In vitro studies indicate that small amounts of both Serum beta 2m (S-beta 2m) and Serum cystatin C (S-cC) are adsorbed to or sieved through the Cuprophan membrane, findings which render the kinetics of LMW proteins during hemodialysis still more complex.	cuprammonium cellulose	145-154	cystatin C	Homo sapiens	89-99
2540072-5	1989	Results of in vitro experiments with cross-incubation of erythrocytes and blood plasma and incubation of whole blood with cuprophan membrane suggest existence of an SOD-1 activator in the uremic blood plasma, which is possibly eliminated during HD.	cuprammonium cellulose	122-131	superoxide dismutase 1	Homo sapiens	165-170
2812169-1	1989	During hemodialysis on cuprophane membranes, platelets are activated and release in plasma alpha-granule-specific substances such as PF4 or platelet-derived growth factor (PDGF).	cuprammonium cellulose	23-33	platelet factor 4	Homo sapiens	133-136
3060434-8	1988	Thus intratreatment concentration changes of B2M in cuprophane dialysis reflect simultaneous changes of B2M distribution volume.	cuprammonium cellulose	52-62	beta-2-microglobulin	Homo sapiens	45-48
3184764-2	1988	During hemodialysis on new cuprophan membranes raised levels not only of C3a, but in addition of activated C3, C5a, and Ba were demonstrated.	cuprammonium cellulose	27-36	complement C3	Homo sapiens	73-76
3184764-2	1988	During hemodialysis on new cuprophan membranes raised levels not only of C3a, but in addition of activated C3, C5a, and Ba were demonstrated.	cuprammonium cellulose	27-36	complement C5a receptor 1	Homo sapiens	111-114
3266309-3	1988	During hemodialysis with four different membranes, plasma IL-1 activity rose with Cuprophan and Hemophan and was unchanged or reduced with Gambrane and Polysulfon.	cuprammonium cellulose	82-91	interleukin 1 alpha	Homo sapiens	58-62
2454413-7	1988	Plasma PSTI values increased during hemodialysis with dialyzers made of cuprophan (317.0 +/- 32.6 vs. 422.0 +/- 46.2 ng/ml; p less than 0.05) and decreased with polysulfone dialyzers (226.6 +/- 19.9 vs. 86.6 +/- 18.1 ng/ml).	cuprammonium cellulose	72-81	serine peptidase inhibitor Kazal type 1	Homo sapiens	7-11
3147418-9	1988	Haemodialysis with cuprophane membranes was associated with an increase in beta 2-microglobulin of 11.5%, whereas haemodialysis with polycarbonate was associated with a decrease of 6.8% at 6 h.(ABSTRACT TRUNCATED AT 250 WORDS)	cuprammonium cellulose	19-29	beta-2-microglobulin	Homo sapiens	75-95
3147419-5	1988	C3d accumulation paralleled the time course of neutropenia only with cuprophane and cellulose acetate.	cuprammonium cellulose	69-79	endogenous retrovirus group K member 13	Homo sapiens	0-3
3140102-4	1988	In acute studies, plasma beta 2M (corrected for haemo-concentration) increased, although not significantly, during cuprophan dialysis (n = 10) from 40.6 +/- 12.2 to 44.8 +/- 7.6 micrograms/ml and decreased during AN69 dialysis (n = 10) from 39.4 +/- 18.0 to 24.3 +/- 7.1 micrograms/ml (P less than 0.02).	cuprammonium cellulose	115-124	beta-2-microglobulin	Homo sapiens	25-32
3140102-5	1988	After 15 min ultrafiltration, beta 2M sieving coefficient in vivo was 0.33 for AN69 but near zero for cuprophan.	cuprammonium cellulose	102-111	beta-2-microglobulin	Homo sapiens	30-37
3140130-1	1988	This study investigates the Il-1 production in vitro by normal peripheral blood monocytes or non-T cells following contact with different dialysis membranes (cuprophan, polysulphone, polymethylmethacrylate and polyacrylonitrile), in the presence or absence of lipopolysaccharide.	cuprammonium cellulose	158-167	interleukin 1 alpha	Homo sapiens	28-32
3626294-3	1987	Reuse of cuprophan dialyzers significantly attenuated the fall in leukocyte counts and the rise in C3a des Arg seen during first use dialysis.	cuprammonium cellulose	9-18	complement C3	Homo sapiens	99-102
3110692-5	1987	During one single session of dialysis, using cuprophane membranes, beta 2m increased acutely at 15 min and had risen by 32.4% at the end of the dialysis session, more than could be explained by haemoconcentration.	cuprammonium cellulose	45-55	beta-2-microglobulin	Homo sapiens	67-74
3557275-10	1986	It is now estimated that carpal tunnel syndrome is induced by accumulation and deposition of beta 2-microglobulin, which increases in blood progressively if used Cuprophane membrane dialyser.	cuprammonium cellulose	162-172	beta-2-microglobulin	Homo sapiens	93-113
3741189-1	1986	Ten patients of a population of 319 on chronic intermittent treatment with Cuprophan dialyzers have undergone surgery for carpal tunnel syndrome (CTS).	cuprammonium cellulose	75-84	transthyretin	Homo sapiens	146-149
3699914-2	1986	CU membranes caused the most intense complement activation with C3a, C3d, and C5a levels peaking 15 min after beginning dialysis.	cuprammonium cellulose	0-2	complement C3	Homo sapiens	64-67
3699914-2	1986	CU membranes caused the most intense complement activation with C3a, C3d, and C5a levels peaking 15 min after beginning dialysis.	cuprammonium cellulose	0-2	complement C5a receptor 1	Homo sapiens	78-81
3496071-3	1987	C3a generation in the module was determined at various time points comparing the cuprammonium cellulose (CC) membrane and four types of modified cellulose (MC) membrane, each with a different degree of hydroxyl (OH-) group substitution.	cuprammonium cellulose	81-103	complement C3	Homo sapiens	0-3
3035392-4	1987	On the other hand, plasma C3a levels were higher in patients dialyzed with the cuprophan compared with the polycarbonate dialyzer.	cuprammonium cellulose	79-88	complement C3	Homo sapiens	26-29
3790264-6	1986	C3a levels, on the other hand, demonstrated significant differences between cuprophan, polyacrylonitrile, and polymethylmethacrylate but not between Cuprophan and polycarbonate membranes.	cuprammonium cellulose	76-85	complement C3	Homo sapiens	0-3
3110692-7	1987	After re-exposure to cuprophane serum beta 2m increased to the original value.	cuprammonium cellulose	21-31	beta-2-microglobulin	Homo sapiens	38-45
3730164-3	1986	While polyacrylonitrile dialyzers did not activate complement to a significant extent, we did observe transient elevations in the plasma concentration of C3a and corresponding diminutions in the granulocyte counts of patients dialyzed with both cuprophane and polycarbonate dialyzers.	cuprammonium cellulose	245-255	complement C3	Homo sapiens	154-157
3730166-2	1986	Cuprophan induced a marked leukopenia with significant plasma C5a generation.	cuprammonium cellulose	0-9	complement C5a receptor 1	Homo sapiens	62-65
6544771-1	1984	Human prothrombin in Tyrode"s solution, in mock plasma (albumin, fibrinogen, and IgG mixture), and in citrated plasma adsorbs to Cuprophane, polyvinylchloride, and polyacrylonitrile surfaces.	cuprammonium cellulose	129-139	coagulation factor II, thrombin	Homo sapiens	6-17
3879955-1	1985	Determining the relative percentage of LMC in PBL histograms of RDT patients during hemodialysis we observed a temporary decrease of the LMC proportion during the first 15 minutes of hemodialysis using Cuprophan in contrast to AN 69S and MC Cellulose.	cuprammonium cellulose	202-211	C-C motif chemokine ligand 16	Homo sapiens	39-42
3879955-1	1985	Determining the relative percentage of LMC in PBL histograms of RDT patients during hemodialysis we observed a temporary decrease of the LMC proportion during the first 15 minutes of hemodialysis using Cuprophan in contrast to AN 69S and MC Cellulose.	cuprammonium cellulose	202-211	C-C motif chemokine ligand 16	Homo sapiens	137-140
6544771-3	1984	The surface concentrations of prothrombin are highest on polyacrylonitrile, second on polyvinylchloride, and lowest on Cuprophane at all prothrombin concentrations tested in the bulk solution.	cuprammonium cellulose	119-129	coagulation factor II, thrombin	Homo sapiens	30-41
6544771-7	1984	Prothrombin bound to Cuprophane seems to promote granulocyte adhesion, but has no effect on platelet adhesion.	cuprammonium cellulose	21-31	coagulation factor II, thrombin	Homo sapiens	0-11
681830-5	1978	The surface saturation concentration (ng/cm2) for albumin, fibrinogen, or IgG were all found to be more on PVC (a hydrophobic surface) than on Cuprophane (a hydrophilic surface).	cuprammonium cellulose	143-153	fibrinogen beta chain	Homo sapiens	59-69
6736083-3	1984	The labeled antifibrinogen IgG was shown to react specifically with fibrinogen adsorbed and immobilized (by glutaraldehyde) on Cuprophane.	cuprammonium cellulose	127-137	fibrinogen beta chain	Homo sapiens	16-26
6736083-5	1984	The presence of blood cells such as platelets and granulocytes with fibrinogen on Cuprophane reduced only slightly the uptake of 125I- antifibrinogen -IgG.	cuprammonium cellulose	82-92	fibrinogen beta chain	Homo sapiens	68-78
6736083-6	1984	The examination of fibrinogen-fibrin deposition on clinically used Cuprophane by this technique and by autoradiography of the same material following 125I- antifibrinogen -IgG conjugation indicated that the deposition of fibrinogen was heavy and heterogeneous.	cuprammonium cellulose	67-77	fibrinogen beta chain	Homo sapiens	19-29
6609269-1	1983	Measurable complement activation resulting in the formation of both C3a and C5a anaphylatoxins was observed in 12 patients undergoing maintenance dialysis treatment with cuprophan hollow fiber dialyzers.	cuprammonium cellulose	170-179	complement C5a receptor 1	Homo sapiens	76-79
6609270-1	1983	Hemodialysis of 11 endstage renal failure patients with new cuprophan hollow fiber dialyzers produced significant leukopenia as well as increased plasma levels of both C3a and C5a antigens during the initial phases of the procedure.	cuprammonium cellulose	60-69	complement C3	Homo sapiens	168-171
6609270-1	1983	Hemodialysis of 11 endstage renal failure patients with new cuprophan hollow fiber dialyzers produced significant leukopenia as well as increased plasma levels of both C3a and C5a antigens during the initial phases of the procedure.	cuprammonium cellulose	60-69	complement C5a receptor 1	Homo sapiens	176-179
6609270-6	1983	These observations suggest that C3b deposition on the cellulosic membrane surface during first use markedly diminishes the complement activating potential of cuprophan dialyzers when they are subsequently re-used.	cuprammonium cellulose	158-167	endogenous retrovirus group K member 3	Homo sapiens	32-35
6493430-6	1984	The clinical signs linked with hypereosinophilia (13,000/mm3), hyperbasophilia (140/mm3) and an increase in total serum IgE disappeared when cuprophan membrane was replaced by cellulose acetate.	cuprammonium cellulose	141-150	immunoglobulin heavy constant epsilon	Homo sapiens	120-123
6493430-8	1984	We conclude that IgE dependent anaphylaxis might be due to one component of the cuprophan membrane.	cuprammonium cellulose	80-89	immunoglobulin heavy constant epsilon	Homo sapiens	17-20
6609269-1	1983	Measurable complement activation resulting in the formation of both C3a and C5a anaphylatoxins was observed in 12 patients undergoing maintenance dialysis treatment with cuprophan hollow fiber dialyzers.	cuprammonium cellulose	170-179	complement C3	Homo sapiens	68-71
6629526-3	1983	In vitro studies with 125I-labeled human fibrinogen or immunoglobulin G (IgG) showed that the adsorption of fibrinogen or IgG was greater on polyacrylonitrile than on Cuprophane.	cuprammonium cellulose	167-177	fibrinogen beta chain	Homo sapiens	108-118
6629526-6	1983	On the other hand, fibrinogen and IgG augmented greatly the platelet adhesion to Cuprophane and IgG enhanced the granulocyte adhesion moderately.	cuprammonium cellulose	81-91	fibrinogen beta chain	Homo sapiens	19-29
16373999-6	2006	After 90 min recirculation of whole blood, the appearance of IL-6-inducing substances on the blood side was lowest with high-flux PF (1.1 +/- 0.2 ng/ml), slightly higher with low-flux PF (1.9 +/- 0.7 ng/ml) and highest with Cuprophan (4.1 +/- 1 ng/ml).	cuprammonium cellulose	224-233	interleukin 6	Homo sapiens	61-65
5801628-0	1969	[First experiences with the cuprophane coil ExO1].	cuprammonium cellulose	28-38	exonuclease 1	Homo sapiens	44-48
17244155-5	2007	Finally, stimulation with opsonized Escherichia coli or the bioincompatible haemodialysis membrane cuprophane led to up-regulation of GzmA expression at the transcriptional level as well as at the translational level.	cuprammonium cellulose	99-109	granzyme A	Homo sapiens	134-138
20349422-9	2010	RESULTS: We observed a significant increase in caspase-1 activity and decrease in caspase-3 activity in neutrophils after HD with cuprophane, but not with polysulphone.	cuprammonium cellulose	130-140	caspase 1	Homo sapiens	47-56
20349422-9	2010	RESULTS: We observed a significant increase in caspase-1 activity and decrease in caspase-3 activity in neutrophils after HD with cuprophane, but not with polysulphone.	cuprammonium cellulose	130-140	caspase 3	Homo sapiens	82-91
20349422-13	2010	CONCLUSIONS: The results suggest that HD with bioincompatible cuprophane may prolong the life span of neutrophils due to the intense inflammatory reaction and high activity of caspase-1.	cuprammonium cellulose	62-72	caspase 1	Homo sapiens	176-185
16330177-12	2006	Concerning the membranes, the highest levels of CRP were observed in patients dialyzed with Cuprophane with a significant increase from 15.1 +/- 3.6 to 21.2 +/- 3.1 mg/l after 6 months (P < 0.05); a significant reduction of CRP levels was observed in patients dialyzed with polysulfone in the same follow-up period (from 13.5 +/- 2.9 to 8.1 +/- 2.4 mg/l; P < 0.05).	cuprammonium cellulose	92-102	C-reactive protein	Homo sapiens	48-51
16330177-12	2006	Concerning the membranes, the highest levels of CRP were observed in patients dialyzed with Cuprophane with a significant increase from 15.1 +/- 3.6 to 21.2 +/- 3.1 mg/l after 6 months (P < 0.05); a significant reduction of CRP levels was observed in patients dialyzed with polysulfone in the same follow-up period (from 13.5 +/- 2.9 to 8.1 +/- 2.4 mg/l; P < 0.05).	cuprammonium cellulose	92-102	C-reactive protein	Homo sapiens	227-230
11169027-9	2001	RESULTS: The total production (cell-associated plus extracellular) of LPS-induced IL-1beta (proIL-1beta plus mIL-1beta) was similar in healthy controls (25.96 +/- 0.84 ng/2.5 x 10(6) PBMC), PD patients (29.53 +/- 1.31 ng/2.5 x 106 PBMC), and in Cuprophan-treated HD patients (23.28 +/- 1.24 ng/2.5 x 10(6) PBMC).	cuprammonium cellulose	245-254	interleukin 1 beta	Homo sapiens	82-90
16363293-11	2005	HDL-C and Apo A was higher in polysulfone and hemophan than cuprophane group while triglyderide was lower.	cuprammonium cellulose	60-70	lipoprotein(a)	Homo sapiens	10-15
12803505-6	2003	RESULTS: IL-1beta levels increased from 16.6 +/- 2.2 to 64.8 +/- 25.1 pg/mL on CU and 21.5 +/- 3.7 to 103.5 +/- 30.7 pg/mL on PS membrane over the 4-h dialysis session.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	9-17
12803505-7	2003	Similarly TNFalpha increased from 42.8 +/- 4.5 to 354.9 +/- 80.4 pg/mL on CU and 117.1+/- 53.7 to 387.0 +/- 78.0 pg/mL on PS membrane.	cuprammonium cellulose	74-76	tumor necrosis factor	Homo sapiens	10-18
11818679-4	2002	RESULTS: beta(2)M levels were lower with high-flux biocompatible than with low-flux biocompatible or cuprophane dialysis (22.3 +/- 5.4 vs. 43.4 +/-13.7 and 37.6 +/-13.1 mg/l, respectively; p < 0.001).	cuprammonium cellulose	101-111	beta-2-microglobulin	Homo sapiens	9-17
11549901-9	2001	RESULTS: The results show that incubation of CU membranes with the proteins CD11b, CD18, and CD54 or the blockade of these cell surface molecules with specific monoclonal antibodies inhibited the CU-induced aggregation and apoptosis in a dose-dependent manner.	cuprammonium cellulose	45-47	integrin subunit alpha M	Homo sapiens	76-81
11549901-9	2001	RESULTS: The results show that incubation of CU membranes with the proteins CD11b, CD18, and CD54 or the blockade of these cell surface molecules with specific monoclonal antibodies inhibited the CU-induced aggregation and apoptosis in a dose-dependent manner.	cuprammonium cellulose	45-47	integrin subunit beta 2	Homo sapiens	83-87
11549901-9	2001	RESULTS: The results show that incubation of CU membranes with the proteins CD11b, CD18, and CD54 or the blockade of these cell surface molecules with specific monoclonal antibodies inhibited the CU-induced aggregation and apoptosis in a dose-dependent manner.	cuprammonium cellulose	45-47	intercellular adhesion molecule 1	Homo sapiens	93-97
11169027-1	2001	BACKGROUND: In vitro stimulation of mononuclear cells (peripheral blood mononuclear cells; PBMCs) with an endotoxin (lipopolysaccharide; LPS) revealed elevated cell-associated levels of interleukin-1beta (IL-1beta) in end-stage renal disease (ESRD) patients on Cuprophan hemodialysis (HD), suggesting a defect in the process of IL-1beta"s release from activated cells.	cuprammonium cellulose	261-270	interleukin 1 beta	Homo sapiens	186-203
15890888-8	2005	The results also show that patients dialyzed with less biocompatible membranes have higher serum concentrations of cleaved beta(2)M (mean, 8.5, 1.8, and 0.7 mg/L in cuprophane membrane-dialyzed, polysulfone membrane-dialyzed, and control sera, respectively).	cuprammonium cellulose	165-175	alpha-2-macroglobulin	Homo sapiens	123-131
14751734-2	2004	We have previously shown that Swiss 3T3 cells aggregated on hydrophilic cellulose substratum Cuprophan (CU) establish short linear gap junctions composed of Cx 43 in cell surface plaques.	cuprammonium cellulose	93-102	gap junction protein, alpha 3	Mus musculus	157-162
14751734-2	2004	We have previously shown that Swiss 3T3 cells aggregated on hydrophilic cellulose substratum Cuprophan (CU) establish short linear gap junctions composed of Cx 43 in cell surface plaques.	cuprammonium cellulose	104-106	gap junction protein, alpha 3	Mus musculus	157-162
12381952-6	2002	In 2 of 10 experiments pro-IL-1beta was detected in monocytes interacting with Cu, PS and AN69S membrane.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	27-35
12021524-1	2002	BACKGROUND: Platelet-activating factor (PAF) production during hemodialysis (HD) with cuprophane (CU) membrane has previously been demonstrated, while the results regarding PAF production during HD with AN-69 polyacrylonitrile membrane are dubious.	cuprammonium cellulose	86-96	PCNA clamp associated factor	Homo sapiens	12-38
12021524-1	2002	BACKGROUND: Platelet-activating factor (PAF) production during hemodialysis (HD) with cuprophane (CU) membrane has previously been demonstrated, while the results regarding PAF production during HD with AN-69 polyacrylonitrile membrane are dubious.	cuprammonium cellulose	86-96	PCNA clamp associated factor	Homo sapiens	40-43
12021524-1	2002	BACKGROUND: Platelet-activating factor (PAF) production during hemodialysis (HD) with cuprophane (CU) membrane has previously been demonstrated, while the results regarding PAF production during HD with AN-69 polyacrylonitrile membrane are dubious.	cuprammonium cellulose	98-100	PCNA clamp associated factor	Homo sapiens	12-38
12021524-1	2002	BACKGROUND: Platelet-activating factor (PAF) production during hemodialysis (HD) with cuprophane (CU) membrane has previously been demonstrated, while the results regarding PAF production during HD with AN-69 polyacrylonitrile membrane are dubious.	cuprammonium cellulose	98-100	PCNA clamp associated factor	Homo sapiens	40-43
12021524-2	2002	In this study an attempt is made to show that PAF is produced during HD using AN-69 membrane while comparing this production with the corresponding one from HD with CU.	cuprammonium cellulose	165-167	PCNA clamp associated factor	Homo sapiens	46-49
12021524-3	2002	Since previous studies have indicated that PAF, like the complement system, could also be implicated in HD-related leukopenia and thrombocytopenia (especially when CU membrane is used), the circulating leukocyte and platelet counts as well as the C3a-desArg and SC5b-9 (soluble, nonlytic form of the terminal complement complex) levels were measured.	cuprammonium cellulose	164-166	PCNA clamp associated factor	Homo sapiens	43-46
12021524-13	2002	CONCLUSIONS: PAF is indeed produced during HD with AN-69 membrane, as it is during HD with CU.	cuprammonium cellulose	91-93	PCNA clamp associated factor	Homo sapiens	13-16
11865088-8	2002	Cells with low CD14 expression were also observed when normal or uraemic mononuclear cells were cultured in the presence of CU membrane.	cuprammonium cellulose	124-126	CD14 molecule	Homo sapiens	15-19
11840366-7	2002	The behavior of CRP plasma levels resembled that of IL-6 PBMC release (23.3 +/- 4.7 in CU, 11.0 +/- 2.1 after 3 months in SMC, and 7.9 +/- 1.5 after 6 months in SMC, respectively).	cuprammonium cellulose	87-89	C-reactive protein	Homo sapiens	16-19
11840366-9	2002	Serum albumin increased after 6 months of dialysis with SMC membranes (3.25 +/- 0.09 g/dL in CU and 3.64 +/- 0.07 g/dL in SMC, P < 0.05).	cuprammonium cellulose	93-95	albumin	Homo sapiens	0-13
12147774-5	2002	In addition, exogenous factors (dialysate endotoxin, vascular access, cuprophane dialyser material) have been identified in clinical studies which are also responsible, at least in part, for high serum CRP levels.	cuprammonium cellulose	70-80	C-reactive protein	Homo sapiens	202-205
11575473-3	2001	Our previous studies showed that on Cuprophan, a cellulose membrane (CU) to which vitronectin adhesive protein is poorly adsorbed, Swiss 3T3 cells are rounded and undergo cAMP-dependent aggregation.	cuprammonium cellulose	36-45	vitronectin	Mus musculus	82-93
11169027-13	2001	However, secretion of mIL-1beta increased significantly with F6 HPS (80.6%, P < 0.01) as well as with F60S (76.6%, P < 0.02) compared with Cuprophan.	cuprammonium cellulose	145-154	interleukin 1 beta	Mus musculus	22-31
11169027-16	2001	Secretion of mIL-1beta is impaired in PD and HD patients treated with Cuprophan.	cuprammonium cellulose	70-79	interleukin 1 beta	Mus musculus	13-22
11169027-17	2001	This impaired ability to secrete active mIL-1beta seems to be independent of ICE activity and is normalized when HD-patients are switched from Cuprophan to low- or high-flux polysulfon.	cuprammonium cellulose	143-152	interleukin 1 beta	Mus musculus	40-49
11574733-11	2001	C3a, C5a, and IL-1 levels during Cuprophan and Hemophan treatments were significantly higher than the levels during modified cellulose treatment at 30 and 60 min and Post (p < 0.01).	cuprammonium cellulose	33-42	complement C3	Homo sapiens	0-3
11574733-11	2001	C3a, C5a, and IL-1 levels during Cuprophan and Hemophan treatments were significantly higher than the levels during modified cellulose treatment at 30 and 60 min and Post (p < 0.01).	cuprammonium cellulose	33-42	interleukin 1 alpha	Homo sapiens	14-18
11958287-3	2000	During routine HD with a cuprophane membrane and high molecular weight (HMW) heparin, plasma MPO was rapidly upregulated to maximal levels within 15 min after starting extracorporeal circulation.	cuprammonium cellulose	25-35	myeloperoxidase	Homo sapiens	93-96
11958287-7	2000	As for anticoagulants, nafamostat mesylate (NM) completely suppressed the rise in plasma MPO during HD with cuprophane.	cuprammonium cellulose	108-118	myeloperoxidase	Homo sapiens	89-92
10917003-7	2000	Cuprophane HD induced a significant increase in i-NOS activity from 31 +/- 10 to 48 +/- 12 fmol-1 10(6) cells (p < 0.05).	cuprammonium cellulose	0-10	nitric oxide synthase 2	Homo sapiens	48-53
10879665-10	2000	The whole blood content of IL-1Ra was higher when patients were dialyzed with cuprophan (1,062 +/- 119 pg/ml) compared to the same patients on polyamide (906 +/- 78 pg/ml, p < 0.05) or on polycarbonate (973 +/- 80 pg/ml, n.s.).	cuprammonium cellulose	78-87	interleukin 1 receptor antagonist	Homo sapiens	27-33
9890318-4	1999	In vitro incubation of isolated neutrophils in the presence of serum with hollow fibers of CU or polysulfone showed similar results: Only CU resulted in upregulation of CD11b and CD66b expression (by 65.5 +/- 18.7% and 60.1 +/- 24%) and a decrease in CD62L expression (by 60.6 +/- 18.2%).	cuprammonium cellulose	138-140	integrin subunit alpha M	Homo sapiens	169-174
11721441-6	1999	CONCLUSIONS: Hemodialysis using a cuprophane membrane can induce rapid upregulation of CD11b and down-regulation of L-selectin, which might influence the normal adhesion and anti-inflammatory response of leukocytes.	cuprammonium cellulose	34-44	integrin subunit alpha M	Homo sapiens	87-92
11721441-6	1999	CONCLUSIONS: Hemodialysis using a cuprophane membrane can induce rapid upregulation of CD11b and down-regulation of L-selectin, which might influence the normal adhesion and anti-inflammatory response of leukocytes.	cuprammonium cellulose	34-44	selectin L	Homo sapiens	116-126
9950176-6	1999	Platelet activation (anti-CD62 and antifibrinogen binding) occurred only with Cuprophan.	cuprammonium cellulose	78-87	selectin P	Homo sapiens	26-30
9950176-8	1999	However, only Cuprophan induced an increase in anti-CD62 binding to neutrophils, suggesting that the aggregated platelets linked to neutrophils were activated.	cuprammonium cellulose	14-23	selectin P	Homo sapiens	52-56
10449868-4	1999	Upregulation of CD11b/CD18 molecule on neutrophils was found with all membranes, to a greater extent with the dialyser containing cuprophan.	cuprammonium cellulose	130-139	integrin subunit alpha M	Homo sapiens	16-21
10449868-4	1999	Upregulation of CD11b/CD18 molecule on neutrophils was found with all membranes, to a greater extent with the dialyser containing cuprophan.	cuprammonium cellulose	130-139	integrin subunit beta 2	Homo sapiens	22-26
10449868-5	1999	The expression of CD11b/CD18 on monocytes was slightly affected with cuprophan only.	cuprammonium cellulose	69-78	integrin subunit alpha M	Homo sapiens	18-23
10449868-5	1999	The expression of CD11b/CD18 on monocytes was slightly affected with cuprophan only.	cuprammonium cellulose	69-78	integrin subunit beta 2	Homo sapiens	24-28
9890318-2	1999	In patients dialyzed with CU, CD11b and CD66b upregulation on neutrophils (by 104.3 +/- 37.9% and 85.7 +/- 31.1%, respectively), and a downregulation of L-selectin (by 44.9 +/- 26.9%) was seen, whereas expression of CD11a remained unaltered.	cuprammonium cellulose	26-28	CEA cell adhesion molecule 8	Homo sapiens	40-45
9890318-2	1999	In patients dialyzed with CU, CD11b and CD66b upregulation on neutrophils (by 104.3 +/- 37.9% and 85.7 +/- 31.1%, respectively), and a downregulation of L-selectin (by 44.9 +/- 26.9%) was seen, whereas expression of CD11a remained unaltered.	cuprammonium cellulose	26-28	selectin L	Homo sapiens	153-163
9890318-2	1999	In patients dialyzed with CU, CD11b and CD66b upregulation on neutrophils (by 104.3 +/- 37.9% and 85.7 +/- 31.1%, respectively), and a downregulation of L-selectin (by 44.9 +/- 26.9%) was seen, whereas expression of CD11a remained unaltered.	cuprammonium cellulose	26-28	integrin subunit alpha L	Homo sapiens	216-221
9890318-4	1999	In vitro incubation of isolated neutrophils in the presence of serum with hollow fibers of CU or polysulfone showed similar results: Only CU resulted in upregulation of CD11b and CD66b expression (by 65.5 +/- 18.7% and 60.1 +/- 24%) and a decrease in CD62L expression (by 60.6 +/- 18.2%).	cuprammonium cellulose	138-140	CEA cell adhesion molecule 8	Homo sapiens	179-184
9890318-4	1999	In vitro incubation of isolated neutrophils in the presence of serum with hollow fibers of CU or polysulfone showed similar results: Only CU resulted in upregulation of CD11b and CD66b expression (by 65.5 +/- 18.7% and 60.1 +/- 24%) and a decrease in CD62L expression (by 60.6 +/- 18.2%).	cuprammonium cellulose	138-140	selectin L	Homo sapiens	251-256
9890318-7	1999	By using C5-depleted serum instead of normal human serum, up-/down-regulation of CD11b, CD62L, and CD66b by CU was dramatically reduced, whereas C3-depleted serum did not produce that effect.	cuprammonium cellulose	108-110	integrin subunit alpha M	Homo sapiens	81-86
9890318-7	1999	By using C5-depleted serum instead of normal human serum, up-/down-regulation of CD11b, CD62L, and CD66b by CU was dramatically reduced, whereas C3-depleted serum did not produce that effect.	cuprammonium cellulose	108-110	selectin L	Homo sapiens	88-93
9890318-7	1999	By using C5-depleted serum instead of normal human serum, up-/down-regulation of CD11b, CD62L, and CD66b by CU was dramatically reduced, whereas C3-depleted serum did not produce that effect.	cuprammonium cellulose	108-110	CEA cell adhesion molecule 8	Homo sapiens	99-104
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	cuprammonium cellulose	169-179	integrin subunit alpha M	Homo sapiens	68-73
9790077-8	1998	The differences in EPO adsorption between AN69 and Cuprophan, demonstrated in vitro, do not seem to be of clinical importance.	cuprammonium cellulose	51-60	erythropoietin	Homo sapiens	19-22
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	cuprammonium cellulose	105-107	interleukin 6	Homo sapiens	209-213
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	cuprammonium cellulose	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	cuprammonium cellulose	105-107	C-C motif chemokine ligand 2	Homo sapiens	224-229
15348869-3	1998	The flow cell is used to conduct an investigation into the in vitro generation of C3a by a regenerated cellulose membrane, Cuprophan.	cuprammonium cellulose	123-132	complement C3	Homo sapiens	82-85
15348869-4	1998	The effects of experimental variables such as temperature, blood flow rate, contact area and wall shear rate on C3a generation by Cuprophan were studied.	cuprammonium cellulose	130-139	complement C3	Homo sapiens	112-115
15348869-5	1998	The results show that C3a generation by Cuprophan is lower at 12 degrees C than at 22 degrees C, which is in turn lower than C3a generation at 37 degrees C. Furthermore, a decrease in contact area, and increase in wall shear rate and blood flow rate, can produce a decrease in C3a concentration.	cuprammonium cellulose	40-49	complement C3	Homo sapiens	22-25
9681723-9	1998	Delta-PMA and delta-fMLP for CD45, CD11c and CD14 showed a decrease during cuprophane dialysis vs t0; again there were no differences between heparin and citrate.	cuprammonium cellulose	75-85	CD14 molecule	Homo sapiens	45-49
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	cuprammonium cellulose	169-179	protein tyrosine phosphatase receptor type C	Homo sapiens	85-89
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	cuprammonium cellulose	169-179	CD14 molecule	Homo sapiens	125-129
9681723-8	1998	The expression of CD11b, CD11c and CD45 on granulocytes increased markedly during cuprophane dialysis with a peak at 15 min; there were no differences in response between heparin and citrate anticoagulation.	cuprammonium cellulose	82-92	integrin subunit alpha M	Homo sapiens	18-23
9681723-8	1998	The expression of CD11b, CD11c and CD45 on granulocytes increased markedly during cuprophane dialysis with a peak at 15 min; there were no differences in response between heparin and citrate anticoagulation.	cuprammonium cellulose	82-92	protein tyrosine phosphatase receptor type C	Homo sapiens	35-39
9681723-9	1998	Delta-PMA and delta-fMLP for CD45, CD11c and CD14 showed a decrease during cuprophane dialysis vs t0; again there were no differences between heparin and citrate.	cuprammonium cellulose	75-85	formyl peptide receptor 1	Homo sapiens	20-24
9681723-9	1998	Delta-PMA and delta-fMLP for CD45, CD11c and CD14 showed a decrease during cuprophane dialysis vs t0; again there were no differences between heparin and citrate.	cuprammonium cellulose	75-85	protein tyrosine phosphatase receptor type C	Homo sapiens	29-33
9681723-9	1998	Delta-PMA and delta-fMLP for CD45, CD11c and CD14 showed a decrease during cuprophane dialysis vs t0; again there were no differences between heparin and citrate.	cuprammonium cellulose	75-85	integrin subunit alpha X	Homo sapiens	35-40
9491904-3	1998	5-LO gene expression was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in samples of mononuclear cells isolated from peripheral blood withdrawn at the start and at 15 min of HD from 10 chronic HD patients, 5 treated with Cuprophan and 5 with polymethylmethacrylate (PMMA) membrane.	cuprammonium cellulose	244-253	arachidonate 5-lipoxygenase	Homo sapiens	0-4
9631846-7	1998	TNF-alpha levels increased by an average of 18.3% during dialysis with cuprophane membranes but only 2.4% with PMMA membranes (P = 0.04).	cuprammonium cellulose	71-81	tumor necrosis factor	Homo sapiens	0-9
9573556-7	1998	In patients treated with CU, serum HGF rose from 0.24 ng/ml at T0 to 7.44 ng/ml at T15, and remained high at T240.	cuprammonium cellulose	25-27	hepatocyte growth factor	Homo sapiens	35-38
9763906-0	1998	The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis.	cuprammonium cellulose	58-68	PCNA clamp associated factor	Homo sapiens	12-15
9763906-6	1998	This study suggested that PAF and LTB4 may be the control elements in biocompatibility in hemodialysis with cuprophane membranes, and demonstrated that the effects of activation last until the following session.	cuprammonium cellulose	108-118	PCNA clamp associated factor	Homo sapiens	26-29
9551416-6	1998	In vitro incubation of normal, C4A- or C4B-deficient serum with cuprophane caused complement activation after fifteen minutes.	cuprammonium cellulose	64-74	complement C4A (Rodgers blood group)	Homo sapiens	31-34
9551416-9	1998	In one patient with severe immunoglobulin deficiency, C3a and TCC levels increased only moderately after 25 minutes of cuprophane dialysis.	cuprammonium cellulose	119-129	complement C3	Homo sapiens	54-57
9551416-13	1998	Incubation of normal serum with cuprophane, however, caused a slight increase in C4a after five minutes.	cuprammonium cellulose	32-42	complement C4A (Rodgers blood group)	Homo sapiens	81-84
9491904-4	1998	An increased 5-LO gene expression was detected at 15 min in 4 of 5 patients using the Cuprophan membrane but in none of the 5 PMMA treated patients.	cuprammonium cellulose	86-95	arachidonate 5-lipoxygenase	Homo sapiens	13-17
9569128-2	1998	We have recently shown that the enhanced neutrophil reactive oxygen species (ROS) production during the early phase of HD with cuprophan (CUP) is sustained by neutrophils which have bound platelets through P-selectin (CD62P).	cuprammonium cellulose	127-136	selectin P	Homo sapiens	206-216
9569128-2	1998	We have recently shown that the enhanced neutrophil reactive oxygen species (ROS) production during the early phase of HD with cuprophan (CUP) is sustained by neutrophils which have bound platelets through P-selectin (CD62P).	cuprammonium cellulose	127-136	selectin P	Homo sapiens	218-223
9513760-5	1998	A significant increase in TNF alpha mRNA was detected at 15 min of hemodialysis in 12 of 22 patients: 5 of 9 treated with cuprophan; 3 of 3 with cellulose triacetate; 3 of 5 with polysulfone, and only 1 of 5 treated with polymethyl-methacrylate membranes.	cuprammonium cellulose	122-131	tumor necrosis factor	Homo sapiens	26-35
9428454-7	1998	During hemodialysis, cuprophane membrane induced an upregulation of granulocyte CD11b, a decrease in granulocyte L-selectin, and an increase in sL-selectin serum levels.	cuprammonium cellulose	21-31	integrin subunit alpha M	Homo sapiens	80-85
9428454-7	1998	During hemodialysis, cuprophane membrane induced an upregulation of granulocyte CD11b, a decrease in granulocyte L-selectin, and an increase in sL-selectin serum levels.	cuprammonium cellulose	21-31	selectin L	Homo sapiens	113-123
9360100-12	1997	In HD patients, EPO resistance may caused either by absorption of rHuEPO to the cuprophan M, or an increased release of cytokines that inhibit erythropoiesis, such as IL-1 beta, TNF-alpha, and IFN-gamma, and to a decrease in stimulatory cytokines such as IL-3, IL-6, and IL-10.	cuprammonium cellulose	80-89	erythropoietin	Homo sapiens	16-19
9506789-0	1997	Beta2-microglobulin and IgE release during hemodialysis with cuprophan membrane.	cuprammonium cellulose	61-70	beta-2-microglobulin	Homo sapiens	0-19
9175051-4	1997	The ability to activate complement, measured as changes in the plasma concentrations of C3a des Arg and the terminal complement complex, and to produce leukopenia was greater for the dialyser containing Cuprophan membrane than for the other three.	cuprammonium cellulose	203-212	complement C3	Homo sapiens	88-91
9360150-8	1997	Cuprophan, on the contrary, causes a sudden increase in erythrocyte SOD, while erythrocyte catalase decreases.	cuprammonium cellulose	0-9	superoxide dismutase 1	Homo sapiens	68-71
9360150-9	1997	These data support the view that Bioflux induces an OS lower than cuprophan because with the former, increased H2O2 production leads (thanks to catalase and GPx action) to water generation.	cuprammonium cellulose	66-75	catalase	Homo sapiens	144-152
9360150-10	1997	With cuprophan, instead the reduced SOD/catalase ratio causes a greater H2O2 generation and a lower conversion to water.	cuprammonium cellulose	5-14	superoxide dismutase 1	Homo sapiens	36-39
9360150-10	1997	With cuprophan, instead the reduced SOD/catalase ratio causes a greater H2O2 generation and a lower conversion to water.	cuprammonium cellulose	5-14	catalase	Homo sapiens	40-48
9347661-8	1997	The beta-2 microglobulin productions (microgram/L) were shown as follows; Control CUP CD PS PAN [table: see text] (*p < 0.05 compared to cuprophane membrane).	cuprammonium cellulose	140-150	beta-2-microglobulin	Homo sapiens	4-24
9198046-4	1997	Since atherogenesis is considered to be accelerated in dialysis patients, we attempted to investigate whether gene expression of SR and alpha 2MG/LRP are altered in peripheral blood monocytes from patients on haemodialysis with a cuprophane (Cu) or polymethylmethacrylate (PMMA) membranes.	cuprammonium cellulose	230-240	LDL receptor related protein 1	Homo sapiens	146-149
9146748-4	1997	Our results show that, as compared with pre-dialysis leucocytes, 15 min of cuprophane haemodialysis impaired leucocyte rolling by 78 +/- 7%, reduced N-formyl-methionyl-leucyl-phenylalanin (fMLP)-induced adhesion by 34 +/- 9%, and abolished transendothelial migration.	cuprammonium cellulose	75-85	formyl peptide receptor 1	Homo sapiens	149-187
9093890-1	1997	The present study aimed to assess the influence of acetate (AC) and bicarbonate (BI) hemodialysis with a cuprophane membrane on plasma erythropoietin (EPO) levels in 30 patients with chronic renal failure (CRF).	cuprammonium cellulose	105-115	erythropoietin	Homo sapiens	135-149
9093890-1	1997	The present study aimed to assess the influence of acetate (AC) and bicarbonate (BI) hemodialysis with a cuprophane membrane on plasma erythropoietin (EPO) levels in 30 patients with chronic renal failure (CRF).	cuprammonium cellulose	105-115	erythropoietin	Homo sapiens	151-154
9274839-1	1997	Hemodialysis with new cuprophane membranes upregulates expression of granulocyte adhesion molecules and activates 5-lipoxygenase as reflected by the enhanced generation of leukotriene B4 (LTB4).	cuprammonium cellulose	22-32	arachidonate 5-lipoxygenase	Homo sapiens	114-128
9297604-4	1997	The applicability of the assay, and the time course of kallikrein generation was demonstrated with glass and cuprophan.	cuprammonium cellulose	109-118	kallikrein related peptidase 4	Homo sapiens	55-65
9027784-2	1997	METHODS: Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic haemodialysis by means of either polysulphone (10 patients) or cuprophane membranes (10 patients) and compared to that of normal controls.	cuprammonium cellulose	215-225	interleukin 1 alpha	Homo sapiens	23-27
9274839-4	1997	Dialysis with new cuprophane but not with new acrylonitrile membranes significantly upregulated expression of CD11b and CD18 by 6-fold and 4-fold, respectively.	cuprammonium cellulose	18-28	integrin subunit alpha M	Homo sapiens	110-115
9274839-4	1997	Dialysis with new cuprophane but not with new acrylonitrile membranes significantly upregulated expression of CD11b and CD18 by 6-fold and 4-fold, respectively.	cuprammonium cellulose	18-28	integrin subunit beta 2	Homo sapiens	120-124
9274839-7	1997	These data indicate that ex vivo dialysis with cuprophane membranes upregulates expression of CD11b and CD18 on granulocytes independent of the activation of 5-lipoxygenase.	cuprammonium cellulose	47-57	integrin subunit alpha M	Homo sapiens	94-99
9274839-7	1997	These data indicate that ex vivo dialysis with cuprophane membranes upregulates expression of CD11b and CD18 on granulocytes independent of the activation of 5-lipoxygenase.	cuprammonium cellulose	47-57	integrin subunit beta 2	Homo sapiens	104-108
8887291-10	1996	There was a significant decrease in pre-dialysis plasma beta 2-microglobulin levels in high-flux dialysis of 9.04 +/- 10.46 mg/liter (23%) and in hemodiafiltration of 6.35 +/- 12.28 mg/liter (16%), both using high-flux polysulfone membrane in comparison with Cuprophan and low-flux polysulfone membranes (P = 0.032).	cuprammonium cellulose	259-268	beta-2-microglobulin	Homo sapiens	56-76
9380601-3	1997	CRP serum levels during haemodialysis with the use of cuprophane membranes increased from 4743.3 +/- 3251.6 ng/ml to 5231.8 +/- 3458.4 ng/ml just after haemodialysis and 5865.4 +/- 3684.8 ng/ml 22 hours after haemodialysis (p < 0.001).	cuprammonium cellulose	54-64	C-reactive protein	Homo sapiens	0-3
9380601-5	1997	Re-counted CRP values, according to changes in total blood protein, increased significantly (p < 0.02) 22 hours after haemodialysis with the use of cuprophane membranes.	cuprammonium cellulose	151-161	C-reactive protein	Homo sapiens	11-14
8948528-3	1996	A significant decrease in SOD activity was found in HD groups using polyacrylonitrile- or cuprophane-type dialysis membrane.	cuprammonium cellulose	90-100	superoxide dismutase 1	Homo sapiens	26-29
8841854-8	1996	In particular MPV showed a decrease throughout the session (-5% at 30" and -9% at 240") while S, beta TG and PF4 peripheral blood levels showed a significant increase at the same intervals with CU membrane.	cuprammonium cellulose	194-196	platelet factor 4	Homo sapiens	109-112
8866218-3	1996	Monoclonal antibody to the CD34 antigen was covalently coupled to the lumenal surface of cuprophan minidialysers (surface area 220 cm2).	cuprammonium cellulose	89-98	CD34 molecule	Homo sapiens	27-31
8671854-0	1996	Cuprophane haemodialysis induces upregulation of LPS receptor (CD14) on monocytes: role of complement activation.	cuprammonium cellulose	0-10	CD14 molecule	Homo sapiens	63-67
8671854-4	1996	RESULTS: In vitro haemodialysis of whole blood from healthy volunteers on cuprophane membrane resulted within 30 min in upregulation of monocyte CD14 expression.	cuprammonium cellulose	74-84	CD14 molecule	Homo sapiens	145-149
8671854-6	1996	Moreover, incubation of whole blood with recombinant C5a led to an increased monocyte CD14 expression supporting a role for complement activation in the rapid cuprophane-induced CD14 upregulation.	cuprammonium cellulose	159-169	complement C5a receptor 1	Homo sapiens	53-56
8671854-5	1996	The reuse of the cuprophane membrane abolished both complement activation and CD14 upregulation.	cuprammonium cellulose	17-27	CD14 molecule	Homo sapiens	78-82
8671854-6	1996	Moreover, incubation of whole blood with recombinant C5a led to an increased monocyte CD14 expression supporting a role for complement activation in the rapid cuprophane-induced CD14 upregulation.	cuprammonium cellulose	159-169	CD14 molecule	Homo sapiens	86-90
8675359-12	1996	These studies show that CD11b/CD18 mobilizing serum factors are generated after incubation with CU membranes and that such factors are probably adsorbed by PS.	cuprammonium cellulose	96-98	integrin subunit alpha M	Homo sapiens	24-29
8671854-6	1996	Moreover, incubation of whole blood with recombinant C5a led to an increased monocyte CD14 expression supporting a role for complement activation in the rapid cuprophane-induced CD14 upregulation.	cuprammonium cellulose	159-169	CD14 molecule	Homo sapiens	178-182
8671854-9	1996	In vivo dialysis on cuprophane membrane also resulted in early monocyte CD14 upregulation as indicated by higher CD14 expression found after 60 min on monocytes obtained from the efferent as compared to the afferent line of the dialyser, a phenomenon that was not observed during haemodialysis on AN69 membrane.	cuprammonium cellulose	20-30	CD14 molecule	Homo sapiens	72-76
8671854-9	1996	In vivo dialysis on cuprophane membrane also resulted in early monocyte CD14 upregulation as indicated by higher CD14 expression found after 60 min on monocytes obtained from the efferent as compared to the afferent line of the dialyser, a phenomenon that was not observed during haemodialysis on AN69 membrane.	cuprammonium cellulose	20-30	CD14 molecule	Homo sapiens	113-117
8671854-10	1996	CONCLUSION: Haemodialysis on the complement-activating cuprophane membrane induces the rapid upregulation of the CD14 LPS-receptor on monocytes.	cuprammonium cellulose	55-65	CD14 molecule	Homo sapiens	113-117
8675359-12	1996	These studies show that CD11b/CD18 mobilizing serum factors are generated after incubation with CU membranes and that such factors are probably adsorbed by PS.	cuprammonium cellulose	96-98	integrin subunit beta 2	Homo sapiens	30-34
8659500-4	1996	We studied the effects of a single dialysis session with new cuprophane membrane on the soluble (s) form of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules with a variety of immunologic roles.	cuprammonium cellulose	61-71	intercellular adhesion molecule 1	Homo sapiens	108-141
8573001-6	1995	The plasma concentrations of beta-thromboglobulin (ELISA) did not differ between the examinations made during rHuEPO and before rHuEPO therapy; however, statistically significant differences were found between dialysis sessions involving Cuprophan and AN69HF membranes.	cuprammonium cellulose	238-247	pro-platelet basic protein	Homo sapiens	29-49
8893153-5	1996	In conclusion, granulocytes in the "resting state" expressed more CD45 on their cell membranes during CU dialysis, whereas CD14 and CD45 upregulation after ex vivo addition of PMA was blunted during CU dialysis.	cuprammonium cellulose	102-104	protein tyrosine phosphatase receptor type C	Homo sapiens	66-70
8589297-8	1995	Dialysis with cuprophan, but not with polymethylmethacrylate, induced in endothelial cells the expression of mRNA encoding for inducible NO synthase.	cuprammonium cellulose	14-23	nitric oxide synthase 2	Homo sapiens	127-148
8589297-9	1995	The release of IL-1 beta and TNF-alpha after 6 h by recirculating lymphomonocytes paralleled the NO synthase activity profile in endothelial cells and was significantly higher after cuprophan exposure than after polymethylmethacrylate (P < 0.0001).	cuprammonium cellulose	182-191	interleukin 1 beta	Homo sapiens	15-24
8589297-9	1995	The release of IL-1 beta and TNF-alpha after 6 h by recirculating lymphomonocytes paralleled the NO synthase activity profile in endothelial cells and was significantly higher after cuprophan exposure than after polymethylmethacrylate (P < 0.0001).	cuprammonium cellulose	182-191	tumor necrosis factor	Homo sapiens	29-38
8649616-10	1996	An increase in PLA2 activity was observed in crude plasma with a peak appearing at 15 min when the patients were dialysed with cuprophane and cellulose triacetate membranes.	cuprammonium cellulose	127-137	phospholipase A2 group IB	Homo sapiens	15-19
8649616-12	1996	When PLA2 was assessed in plasma extract, the activity increased only with cuprophane but not with cellulose triacetate membranes.	cuprammonium cellulose	75-85	phospholipase A2 group IB	Homo sapiens	5-9
7783414-4	1995	In contrast, LPS-induced IL-1 beta secretion (secreted amounts in % of total production) was similar to controls in uremic patients, but significantly reduced in ESRD patients on Cuprophan (P < 0.01).	cuprammonium cellulose	179-188	interleukin 1 beta	Homo sapiens	25-34
8655220-0	1995	The production of platelet-activating factor (PAF) during hemodialysis with cuprophane membrane.	cuprammonium cellulose	76-86	PCNA clamp associated factor	Homo sapiens	18-44
8655220-0	1995	The production of platelet-activating factor (PAF) during hemodialysis with cuprophane membrane.	cuprammonium cellulose	76-86	PCNA clamp associated factor	Homo sapiens	46-49
8655220-2	1995	There is evidence that PAF may be produced during hemodialysis (HD) mainly when using cuprophane membrane (CU).	cuprammonium cellulose	86-96	PCNA clamp associated factor	Homo sapiens	23-26
7771486-3	1995	C3a concentrations (microgram/mL) in the arterial and venous blood lines were significantly higher during cuprophan dialysis compared with hemophan and polyamide dialyses (P < 0.001).	cuprammonium cellulose	106-115	complement C3	Homo sapiens	0-3
7771486-4	1995	In addition, the net generation of C3a (microgram/min) was significantly higher during hemodialysis with cuprophan compared with hemophan and polyamide (P < 0.001).	cuprammonium cellulose	105-114	complement C3	Homo sapiens	35-38
7783414-9	1995	We conclude that LPS-induced IL-1 beta secretion, but not total production, is impaired in PBMC from ESRD patients on long-term Cuprophan hemodialysis.	cuprammonium cellulose	128-137	interleukin 1 beta	Homo sapiens	29-38
7619385-4	1995	Likewise, in patients on chronic HD with cuprophan membranes, peripheral blood mononuclear cell (PBMC) content of IL-1Ra in freshly obtained PBMC as well as the production of IL-1Ra by endotoxin-stimulated PBMC from these HD patients was several-fold higher than that in undialyzed patients with CRF, CAPD patients or healthy controls.	cuprammonium cellulose	41-50	interleukin 1 receptor antagonist	Homo sapiens	114-120
7914959-6	1994	Cuprophane membranes induced intense activation of the complement system (as judged by measurement of C3a) and lipooxygenase pathway (leukotriene B4) resulting in alterations of neutrophil kinetics and function.	cuprammonium cellulose	0-10	complement C3	Homo sapiens	102-105
7744517-6	1994	At the start, the mean serum beta 2-microglobulin level was about 18 mg/L in patients treated with a cuprophane membrane, but the levels increased after hemodialysis and reached a plateau, which was always higher than in those treated with polyacrylonitril, which cleared beta 2-microglobulin from the serum.	cuprammonium cellulose	101-111	beta-2-microglobulin	Homo sapiens	29-49
8079969-1	1994	Hemodialysis with complement-activating membranes, such as cuprophane, induces neutropenia and expression of the granulocyte adhesion receptor Mac-1 (CD11b/CD18), while hemodialysis with noncomplement-activating membranes does not.	cuprammonium cellulose	59-69	integrin subunit alpha M	Homo sapiens	143-148
8079969-1	1994	Hemodialysis with complement-activating membranes, such as cuprophane, induces neutropenia and expression of the granulocyte adhesion receptor Mac-1 (CD11b/CD18), while hemodialysis with noncomplement-activating membranes does not.	cuprammonium cellulose	59-69	integrin subunit alpha M	Homo sapiens	150-155
8079969-1	1994	Hemodialysis with complement-activating membranes, such as cuprophane, induces neutropenia and expression of the granulocyte adhesion receptor Mac-1 (CD11b/CD18), while hemodialysis with noncomplement-activating membranes does not.	cuprammonium cellulose	59-69	integrin subunit beta 2	Homo sapiens	156-160
8079969-2	1994	Increased expression of CD11b by neutrophils may mediate cuprophane-induced leukopenia.	cuprammonium cellulose	57-67	integrin subunit alpha M	Homo sapiens	24-29
8079969-7	1994	Hemodialysis with cuprophane induced an increase in C5a concentration and in the expression of CD11b and MoF11 Ag, which were maximal after 15 minutes of hemodialysis, at the nadir of neutropenia.	cuprammonium cellulose	18-28	complement C5a receptor 1	Homo sapiens	52-55
8079969-7	1994	Hemodialysis with cuprophane induced an increase in C5a concentration and in the expression of CD11b and MoF11 Ag, which were maximal after 15 minutes of hemodialysis, at the nadir of neutropenia.	cuprammonium cellulose	18-28	integrin subunit alpha M	Homo sapiens	95-100
7890436-1	1994	An in vivo cross-over study has investigated plasma and cellular levels of IL-1 (IL-1 alpha IL-1 beta and IL-1Ra) when using Cuprophan (C) and cellulose triacetate (CTA) membranes to assess the roles of complement activation and dialysate endotoxin content in the induction of cytokines during the dialysis procedure.	cuprammonium cellulose	125-134	interleukin 1 receptor antagonist	Homo sapiens	75-79
7890436-2	1994	The mean C5a level during Cuprophan dialysis was 29.9 +/- 0.63 ng/ml (Mean +/- SEM), while for the cellulose triacetate dialysis was 3.09 +/- 0.7 ng/ml.	cuprammonium cellulose	26-35	complement C5a receptor 1	Homo sapiens	9-12
7700210-1	1994	We studied the effect of polyacrylonitrile (PAN), polysulfone (PS) and cuprophane (CP) membranes on the removal of intact and middle molecule (MM) parathyroid hormone (PTH) during hemodialysis in 4 patients using a dialysis calcium of 1.0 mmol/l.	cuprammonium cellulose	71-81	parathyroid hormone	Homo sapiens	147-166
7967358-10	1994	When we measured DAG formation in cells that had been kept in the dialyzers without circulation, we found that cells exposed to CU showed a much higher and rapid activation than those exposed to PS or PAN, as if CU per se was able to activate early cell signaling (CU 1.95-; PS 0.97-; PAN 1.09-; DAG, -fold increase over control).	cuprammonium cellulose	128-130	NLR family pyrin domain containing 2	Homo sapiens	285-290
8029123-12	1994	After haemodialysis with cuprophan dialyser a significant decrease SOD and GPX activity was observed.	cuprammonium cellulose	25-34	superoxide dismutase 1	Homo sapiens	67-70
8285196-0	1994	Cuprophane but not synthetic membrane induces increases in serum tumor necrosis factor-alpha levels during hemodialysis.	cuprammonium cellulose	0-10	tumor necrosis factor	Homo sapiens	65-92
8285196-4	1994	Tumor necrosis factor-alpha levels significantly increased during the session with cuprophane, whereas they decreased with AN69.	cuprammonium cellulose	83-93	tumor necrosis factor	Homo sapiens	0-27
8084452-10	1994	CU enhanced 16-fold CD11b expression on PMN, and increased also CD11b and CD25 expression on MO by 7- and 40-fold respectively.	cuprammonium cellulose	0-2	integrin subunit alpha M	Homo sapiens	20-25
8084452-10	1994	CU enhanced 16-fold CD11b expression on PMN, and increased also CD11b and CD25 expression on MO by 7- and 40-fold respectively.	cuprammonium cellulose	0-2	integrin subunit alpha M	Homo sapiens	64-69
8084452-10	1994	CU enhanced 16-fold CD11b expression on PMN, and increased also CD11b and CD25 expression on MO by 7- and 40-fold respectively.	cuprammonium cellulose	0-2	interleukin 2 receptor subunit alpha	Homo sapiens	74-78
7973484-1	1994	In order to assess the prevalence of the carpal tunnel syndrome (CTS) suggestive of beta 2 microglobulin amyloid deposit in patients undergoing hemodialysis with cuprophan and acetate membrane, we studied 30 patients who had been receiving hemodialysis for varying lengths of time.	cuprammonium cellulose	162-171	transthyretin	Homo sapiens	65-68
8294158-2	1993	In this report we have studied the effects of dialysis on myoglobin elimination in patients on CAPD, IPD, cuprophan and polyacrylonitrile (PAN) membrane hemodialysis.	cuprammonium cellulose	106-115	myoglobin	Homo sapiens	58-67
8294158-4	1993	The serum myoglobin levels were 250 +/- 18 and 264 +/- 14 micrograms/l on cuprophan and a 3 month dialysis on PAN membrane, respectively.	cuprammonium cellulose	74-83	myoglobin	Homo sapiens	10-19
8465819-0	1993	Stimulation of mononuclear cells by contact with cuprophan membranes: further increase of beta 2-microglobulin synthesis by activated late complement components.	cuprammonium cellulose	49-58	beta-2-microglobulin	Homo sapiens	90-110
8352255-0	1993	Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.	cuprammonium cellulose	37-46	interleukin 1 receptor antagonist	Homo sapiens	60-93
8352255-0	1993	Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.	cuprammonium cellulose	37-46	interleukin 1 beta	Homo sapiens	98-116
8320924-6	1993	During cuprophane dialysis, t-PA increased significantly at 60 minutes (14.8 vs. 8.4 IU/ml, P < 0.05) and at 120 minutes (13.8 P < 0.01).	cuprammonium cellulose	7-17	plasminogen activator, tissue type	Homo sapiens	28-32
8320925-6	1993	A significant increase in the GMP-140 expression was observed in samples obtained from the outlet line compared with samples obtained from the inlet line for all membranes evaluated, but the extent of this increase depended on the type of membrane used: Cuprophane 13.95 +/- 3.94%, cellulose acetate 7.4 +/- 4.52%, polymethylmethacrylate 6.93 +/- 4.6%, polysulphone 3.83 +/- 2%, and AN-69 2.14 +/- 2.19% (mean +/- SD).	cuprammonium cellulose	254-264	selectin P	Homo sapiens	30-37
8465819-1	1993	Contact of mononuclear cells (MNC) with cuprophan membranes in vitro causes an increase in beta 2-microglobulin (beta 2m) synthesis.	cuprammonium cellulose	40-49	beta-2-microglobulin	Homo sapiens	91-111
8465819-1	1993	Contact of mononuclear cells (MNC) with cuprophan membranes in vitro causes an increase in beta 2-microglobulin (beta 2m) synthesis.	cuprammonium cellulose	40-49	beta-2-microglobulin	Homo sapiens	113-120
8465819-3	1993	After contact with cuprophan, deposition of C5b-9 on the cells was seen, followed by an increase in beta 2m synthesis and cytokine release, exceeding that seen after contact activation in the absence of serum.	cuprammonium cellulose	19-28	beta-2-microglobulin	Homo sapiens	100-107
8399654-6	1993	In 24 patients on hemodialysis using cuprophan membrane the serum level of beta 2M was 55.1 +/- 4.1 mg/L.	cuprammonium cellulose	37-46	beta-2-microglobulin	Homo sapiens	75-82
8463348-9	1993	Albumin, IgG, and antithrombin III were mainly present in the cuprophane eluates.	cuprammonium cellulose	62-72	serpin family C member 1	Homo sapiens	18-34
8249416-2	1993	It was found that the serum M/C-PTH concentration was increased significantly during haemodialysis using Cuprophane dialysers.	cuprammonium cellulose	105-115	parathyroid hormone	Homo sapiens	32-35
8249416-4	1993	The authors believe that the increase of serum M/C-PTH concentration during haemodialysis may be due to unsatisfactory biocompatibility of Cuprophane dialyzing membranes.	cuprammonium cellulose	139-149	parathyroid hormone	Homo sapiens	51-54
8088929-2	1993	The rise in plasma C3a and C5a was intense during haemodialysis with CU, but mild with PAN.	cuprammonium cellulose	69-71	complement C3	Homo sapiens	19-22
8088929-2	1993	The rise in plasma C3a and C5a was intense during haemodialysis with CU, but mild with PAN.	cuprammonium cellulose	69-71	complement C5a receptor 1	Homo sapiens	27-30
8029157-0	1993	[Influence of cuprophane membrane surface dialyzers on beta2-microglobulin serum concentration in patients during hemodialysis].	cuprammonium cellulose	14-24	beta-2-microglobulin	Homo sapiens	55-74
8029157-1	1993	In 14 patients beta 2-microglobulin serum concentration before and after haemodialysis using cuprophane capillary dialyzers with 0.7; 1.2 and 1.5 m2 surface was measured.	cuprammonium cellulose	93-103	beta-2-microglobulin	Homo sapiens	15-35
8029157-10	1993	The above mentioned data indicate that the increase of beta 2-microglobulin after haemodialysis is not related to biocompatibility of cuprophane membrane, but is dependent on intensivity of haemodialysis, which associated with the surface of the membrane.	cuprammonium cellulose	134-144	beta-2-microglobulin	Homo sapiens	55-75
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	5-15	coagulation factor XII	Homo sapiens	62-76
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	5-15	kallikrein related peptidase 4	Homo sapiens	92-102
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	5-15	kallikrein related peptidase 4	Homo sapiens	106-116
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	17-20	coagulation factor XII	Homo sapiens	62-76
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	17-20	kallikrein related peptidase 4	Homo sapiens	92-102
8507811-4	1993	Both cuprophane (CUP) and PAN membranes were able to activate Hageman factor and convert prekallikrein to kallikrein as measured by an ELISA against kallikrein-C1-inactivator complexes.	cuprammonium cellulose	17-20	kallikrein related peptidase 4	Homo sapiens	106-116
1490756-7	1992	A substantial (> 100%) increase in plasma TNF alpha was observed during only 14 out of 84 treatments with CU and 20 out of 47 with PSu, however, the increase in TNF alpha was not statistically significant in either group.	cuprammonium cellulose	109-111	tumor necrosis factor	Homo sapiens	45-54
1482324-6	1992	In 5 selected patients with ETO-sterilized, dry Cuprophan dialyzers, TNF alpha rose from (mean +/- SEM) 17.2 +/- 3.0 (pre-HD) to 20.9 +/- 6.2 (120 min) and 21.9 +/- 4.5 pg/ml (240 min).	cuprammonium cellulose	48-57	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	28-31
1482324-6	1992	In 5 selected patients with ETO-sterilized, dry Cuprophan dialyzers, TNF alpha rose from (mean +/- SEM) 17.2 +/- 3.0 (pre-HD) to 20.9 +/- 6.2 (120 min) and 21.9 +/- 4.5 pg/ml (240 min).	cuprammonium cellulose	48-57	tumor necrosis factor	Homo sapiens	69-78
1395100-0	1992	Alterations in mononuclear cell tumour necrosis factor-alpha (TNF-alpha) response in patients on long term cuprophane haemodialysis.	cuprammonium cellulose	107-117	tumor necrosis factor	Homo sapiens	62-71
1379278-8	1992	Markedly elevated plasma levels of C5a des Arg were found in blood returning from the dialyzer following contact with cuprophane membranes.	cuprammonium cellulose	118-128	complement C5a receptor 1	Homo sapiens	35-38
1405316-6	1992	Compared to IL-6 synthesis in control subjects (6.0 +/- 5.6 U/3 x 10(6) PBMC/24 hr), hemodialyzed patients, when treated with cuprophan membranes, showed significantly higher value of IL-6 production both before (23 +/- 13 U/3 x 10(6) PBMC/24 hr) and after (26.2 +/- 11.3 U/3 x 10(6) PBMC/24 hr) the dialytic session.	cuprammonium cellulose	126-135	interleukin 6	Homo sapiens	12-16
1405316-6	1992	Compared to IL-6 synthesis in control subjects (6.0 +/- 5.6 U/3 x 10(6) PBMC/24 hr), hemodialyzed patients, when treated with cuprophan membranes, showed significantly higher value of IL-6 production both before (23 +/- 13 U/3 x 10(6) PBMC/24 hr) and after (26.2 +/- 11.3 U/3 x 10(6) PBMC/24 hr) the dialytic session.	cuprammonium cellulose	126-135	interleukin 6	Homo sapiens	184-188
1630540-1	1992	We studied the expression of Mac-1 on granulocytes (flow cytometry) from 9 patients (27 examinations) during hemodialysis with cuprophane membranes (CuM).	cuprammonium cellulose	127-137	integrin subunit alpha M	Homo sapiens	29-34
10078234-4	1992	A significant increase in TNF levels by the end of dialysis was found only with Cuprophan (p < 0.01).	cuprammonium cellulose	80-89	tumor necrosis factor	Homo sapiens	26-29
1292337-1	1992	We studied the upregulation of the intracellular glycoprotein Mac-1 (CD11b/CD18, CR3) on monocytes and granulocytes during 36 bicarbonate hemodialyses in 12 patients who were randomly treated with Cuprophan (Cu), Hemophan (He) or Polysulfone (PS; low-flux) membranes.	cuprammonium cellulose	197-206	integrin subunit alpha M	Homo sapiens	62-67
1292337-1	1992	We studied the upregulation of the intracellular glycoprotein Mac-1 (CD11b/CD18, CR3) on monocytes and granulocytes during 36 bicarbonate hemodialyses in 12 patients who were randomly treated with Cuprophan (Cu), Hemophan (He) or Polysulfone (PS; low-flux) membranes.	cuprammonium cellulose	197-199	integrin subunit alpha M	Homo sapiens	62-67
18475443-1	1992	Cuprophane membranes during haemodialysis significantly increase the plasma levels of C5a(desArg) (maximal 55 mug C5a(adesArg)/1 blood after 30 min) whereas Hemophane or Polysulphonemembranes induce only low plasma levels of C5a(desArg).	cuprammonium cellulose	0-10	complement C5a receptor 1	Homo sapiens	86-97
18475443-1	1992	Cuprophane membranes during haemodialysis significantly increase the plasma levels of C5a(desArg) (maximal 55 mug C5a(adesArg)/1 blood after 30 min) whereas Hemophane or Polysulphonemembranes induce only low plasma levels of C5a(desArg).	cuprammonium cellulose	0-10	complement C5a receptor 1	Homo sapiens	225-236
10078234-6	1992	However, a significant increase of intramonocyte TNF levels was found in Cuprophan patients (p < 0.025).	cuprammonium cellulose	73-82	tumor necrosis factor	Homo sapiens	49-52
1751203-7	1991	A parallel in vitro study showed that IL-1 produced during HD requires at least 24 hours to be released, and that both CU and PS are able to bind and clear IL-1.	cuprammonium cellulose	119-121	interleukin 1 alpha	Homo sapiens	156-160
1682387-5	1991	Increases of CD10, CD13, and CD11b but not CD11a (LFA-1) were also observed in leukocytes from patients undergoing hemodialysis with cuprophan membranes.	cuprammonium cellulose	133-142	membrane metalloendopeptidase	Homo sapiens	13-17
1682387-5	1991	Increases of CD10, CD13, and CD11b but not CD11a (LFA-1) were also observed in leukocytes from patients undergoing hemodialysis with cuprophan membranes.	cuprammonium cellulose	133-142	alanyl aminopeptidase, membrane	Homo sapiens	19-23
1682387-5	1991	Increases of CD10, CD13, and CD11b but not CD11a (LFA-1) were also observed in leukocytes from patients undergoing hemodialysis with cuprophan membranes.	cuprammonium cellulose	133-142	integrin subunit alpha M	Homo sapiens	29-34
1762313-3	1991	Immunoblotting of proteins eluted from plasma-treated cuprophan membranes confirmed the presence of both C3b and iC3b.	cuprammonium cellulose	54-63	complement C3	Homo sapiens	105-108
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit alpha M	Homo sapiens	44-49
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit beta 2	Homo sapiens	60-64
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit beta 4	Homo sapiens	70-78
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit alpha X	Homo sapiens	80-85
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit beta 2	Homo sapiens	86-90
1762294-2	1991	The members of the LFA family of integrins, Mac-1/Mo1 (CD11/CD18) and gp150/95 (CD11c/CD18), involved in adhesion of myeloid cells to endothelia and other substrates, were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer, whereas no change was observed in the expression of LFA-1 (CD11a/CD18).	cuprammonium cellulose	281-291	integrin subunit beta 2	Homo sapiens	86-90
1762294-3	1991	By contrast, dialysis with Cuprophane membranes, as well as in vitro treatment with different activating agents, induced a downregulation on the expression of both the Leu-8/LAM-1 antigen, the human neutrophil peripheral lymph node homing receptor, and the CD43 major sialoglycoprotein involved in leukocyte homotypic adhesion.	cuprammonium cellulose	27-37	selectin L	Homo sapiens	168-173
1762294-3	1991	By contrast, dialysis with Cuprophane membranes, as well as in vitro treatment with different activating agents, induced a downregulation on the expression of both the Leu-8/LAM-1 antigen, the human neutrophil peripheral lymph node homing receptor, and the CD43 major sialoglycoprotein involved in leukocyte homotypic adhesion.	cuprammonium cellulose	27-37	selectin L	Homo sapiens	174-179
1762294-3	1991	By contrast, dialysis with Cuprophane membranes, as well as in vitro treatment with different activating agents, induced a downregulation on the expression of both the Leu-8/LAM-1 antigen, the human neutrophil peripheral lymph node homing receptor, and the CD43 major sialoglycoprotein involved in leukocyte homotypic adhesion.	cuprammonium cellulose	27-37	sialophorin	Homo sapiens	257-261
1942777-0	1991	Stimulation of beta 2-microglobulin synthesis in lymphocytes after exposure to Cuprophan dialyzer membranes.	cuprammonium cellulose	79-88	beta-2-microglobulin	Homo sapiens	15-35
1942777-5	1991	Increased beta 2m mRNA was seen after a minimum of one hour contact time with Cuprophan both in the presence and absence of cycloheximide.	cuprammonium cellulose	78-87	beta-2-microglobulin	Homo sapiens	10-17
1942777-6	1991	While no consistent stimulation was seen with polyacrylonitrile or polycarbonate-polyether membranes, respectively, the stimulation of beta 2m mRNA with Cuprophan was of the same order of magnitude as that obtained with interferon gamma.	cuprammonium cellulose	153-162	beta-2-microglobulin	Homo sapiens	135-142
1942777-7	1991	Stimulation of beta 2m mRNA by Cuprophan was stereospecifically diminished by 5 mM L-fucose.	cuprammonium cellulose	31-40	beta-2-microglobulin	Homo sapiens	15-22
1751200-2	1991	During the HD session, both cuprophan (CU) and polysulfone (PS) induced transcription of interleukin-2 receptor (IL-2R) mRNA.	cuprammonium cellulose	28-37	interleukin 2 receptor subunit alpha	Homo sapiens	89-111
1751200-2	1991	During the HD session, both cuprophan (CU) and polysulfone (PS) induced transcription of interleukin-2 receptor (IL-2R) mRNA.	cuprammonium cellulose	28-37	interleukin 2 receptor subunit alpha	Homo sapiens	113-118
1751200-2	1991	During the HD session, both cuprophan (CU) and polysulfone (PS) induced transcription of interleukin-2 receptor (IL-2R) mRNA.	cuprammonium cellulose	39-41	interleukin 2 receptor subunit alpha	Homo sapiens	89-111
1751200-2	1991	During the HD session, both cuprophan (CU) and polysulfone (PS) induced transcription of interleukin-2 receptor (IL-2R) mRNA.	cuprammonium cellulose	39-41	interleukin 2 receptor subunit alpha	Homo sapiens	113-118
1799184-6	1991	An increase of SIL2R concentration due to abnormal T cell preactivation in HD patients with nonreused cuprophan membranes could perhaps contribute to cell immunity impairment through IL2 binding and inhibition of T cell activation.	cuprammonium cellulose	102-111	interleukin 2	Homo sapiens	16-19
1996568-4	1991	Our data suggest that hemodialysis with cuprophane membrane is associated with monocyte and PMNL activation as shown by production of ROS coincident with peak activation of the complement cascade; these granulocytes become refractory to further stimulation with C5a and FMLP during dialysis.	cuprammonium cellulose	40-50	complement C5a receptor 1	Homo sapiens	262-265
1996568-4	1991	Our data suggest that hemodialysis with cuprophane membrane is associated with monocyte and PMNL activation as shown by production of ROS coincident with peak activation of the complement cascade; these granulocytes become refractory to further stimulation with C5a and FMLP during dialysis.	cuprammonium cellulose	40-50	formyl peptide receptor 1	Homo sapiens	270-274
1992659-6	1991	Dialysis with conventional cuprophane new dialyzers during the primary-use phase of the study resulted in a 3.3% increase in serum beta 2M levels, and a 2.4% increase in serum beta 2M levels during the reuse phase.	cuprammonium cellulose	27-37	beta-2-microglobulin	Homo sapiens	131-138
1992659-6	1991	Dialysis with conventional cuprophane new dialyzers during the primary-use phase of the study resulted in a 3.3% increase in serum beta 2M levels, and a 2.4% increase in serum beta 2M levels during the reuse phase.	cuprammonium cellulose	27-37	beta-2-microglobulin	Homo sapiens	176-183
2067197-0	1991	Hemodialysis with cuprophane membrane modulates interleukin-2 receptor expression.	cuprammonium cellulose	18-28	interleukin 2	Homo sapiens	48-61
2067197-5	1991	Chronic dialysis with new cuprophane membrane leads to an increase in baseline expression of the two subunits of IL-2 receptors.	cuprammonium cellulose	26-36	interleukin 2	Homo sapiens	113-117
2067197-7	1991	However, Phytohemagglutinin (PHA) stimulation of PBMC harvested after two weeks of dialysis with cuprophane membrane showed a markedly decreased expression of high affinity IL-2 receptors.	cuprammonium cellulose	97-107	interleukin 2	Homo sapiens	173-177
2067197-9	1991	The increased expression of IL-2 receptor subunits are reproduced in vitro by direct contact of PBMC with cuprophane membrane and by the addition of the anaphylatoxin C5a.	cuprammonium cellulose	106-116	interleukin 2	Homo sapiens	28-32
1993364-7	1991	In contrast, when cuprophane membranes were used, there was a significant increase in plasma TNF-alpha levels and in both spontaneous (10-fold) and lipopolysaccharide-induced (seven-fold) ex vivo TNF-alpha production by monocytes.	cuprammonium cellulose	18-28	tumor necrosis factor	Homo sapiens	93-102
1993364-7	1991	In contrast, when cuprophane membranes were used, there was a significant increase in plasma TNF-alpha levels and in both spontaneous (10-fold) and lipopolysaccharide-induced (seven-fold) ex vivo TNF-alpha production by monocytes.	cuprammonium cellulose	18-28	tumor necrosis factor	Homo sapiens	196-205
1819211-2	1991	Interleukin-1-beta (IL-1-beta) was measured in the plasma and peripheral blood mononuclear cell lysates of uremic patients undergoing maintenance hemodialysis by means of either cuprophane or polysulfone membranes.	cuprammonium cellulose	178-188	interleukin 1 beta	Homo sapiens	0-18
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	29-38
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	125-134
1775252-6	1991	We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session.	cuprammonium cellulose	19-28	tumor necrosis factor	Homo sapiens	107-110
1758537-5	1991	These data indicate that the increase in the circulating PAF level is not a direct cause of the transient decrease in the neutrophil count, but may be the result of activated neutrophils during hemodialysis with cuprophane membranes.	cuprammonium cellulose	212-222	PCNA clamp associated factor	Homo sapiens	57-60
1775252-6	1991	We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session.	cuprammonium cellulose	19-28	interleukin 1 beta	Homo sapiens	112-115
1775252-3	1991	Circulating levels of TNF and unstimulated production of TNF and IL1 by monocytes were increased in patients dialysed with Hemophan, whereas a greater LPS-stimulated production of TNF was observed in patients dialysed with Cuprophan.	cuprammonium cellulose	223-232	tumor necrosis factor	Homo sapiens	22-25
1775252-5	1991	The alternate use of Cuprophan and Hemophan demonstrated that the production of TNF and IL1 was dependent on the type of haemodialysis membrane.	cuprammonium cellulose	21-30	tumor necrosis factor	Homo sapiens	80-83
1866069-2	1991	Cuprophane induced marked leukopenia with striking plasma generation of C5a.	cuprammonium cellulose	0-10	complement C5a receptor 1	Homo sapiens	72-75
1775252-6	1991	We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session.	cuprammonium cellulose	19-28	interleukin 6	Homo sapiens	120-123
1866079-5	1991	Compared to Il-6 synthesis in control subjects (3.3 +/- 2.8 U/ml) the patients usually haemodialysed with cuprophane membranes showed significantly greater values (9.8 +/- 4.5 U/ml, P less than 0.02 before the treatment, and 10.4 +/- 6.1 U/ml, P less than 0.05 after the treatment).	cuprammonium cellulose	106-116	interleukin 6	Homo sapiens	12-16
1866079-7	1991	In conclusion, our results show increased Il-6 production in haemodialysed patients usually treated with cuprophane membranes, suggesting a chronic stimulation.	cuprammonium cellulose	105-115	interleukin 6	Homo sapiens	42-46
1775252-5	1991	The alternate use of Cuprophan and Hemophan demonstrated that the production of TNF and IL1 was dependent on the type of haemodialysis membrane.	cuprammonium cellulose	21-30	interleukin 1 beta	Homo sapiens	88-91
1775266-5	1991	In comparison to polystyrole (724 +/- 34 pg/ml), IL-6 production by PBMC was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml) and polyacrylonitrile (108 +/- 33 pg/ml).	cuprammonium cellulose	118-127	interleukin 6	Homo sapiens	49-53
2342244-5	1990	In the present study, a method that allows the simultaneous quantification of both fluid phase and membrane bound C3a was used to assess complement activation by PAN and cuprophan.	cuprammonium cellulose	170-179	complement C3	Homo sapiens	114-117
2017267-8	1991	The IL-1 beta levels rose with CU from 87 +/-18 (ng/l) to 155 +/- 33 at 60 min and to 172 +/- 47 at 240 min.	cuprammonium cellulose	31-33	interleukin 1 beta	Homo sapiens	4-13
2266681-2	1990	Chronic dialysis with cuprophane membrane leads to an increase in beta 2m production from 129 +/- 11 ng/ml to 192 +/- 23 ng/ml (P less than 0.002).	cuprammonium cellulose	22-32	beta-2-microglobulin	Homo sapiens	66-73
2266681-4	1990	In addition, during chronic dialysis with cuprophane membrane, an increasing proportion of these cells display low beta 2m expression on their surface (from 6.1 +/- 0.8% of PBMNC to 16.9 +/- 3.4%, P less than 0.001), concomitant with the emergence of cells with low density of HLA on their surface (from 4.9 +/- 1.2% of cells to 32.9 +/- 7.8% of cells, P less than 0.001).	cuprammonium cellulose	42-52	beta-2-microglobulin	Homo sapiens	115-122
2266681-5	1990	The total content of cell-associated beta 2m is also decreased in dialysis patients in general, and in particular in patients chronically dialyzed with new cuprophane membrane.	cuprammonium cellulose	156-166	beta-2-microglobulin	Homo sapiens	37-44
2266681-7	1990	Thus, chronic dialysis with cuprophane membrane may be a factor in the genesis of high beta 2m levels and causes changes in beta 2m and HLA expression on cell surfaces.	cuprammonium cellulose	28-38	beta-2-microglobulin	Homo sapiens	87-94
2266681-7	1990	Thus, chronic dialysis with cuprophane membrane may be a factor in the genesis of high beta 2m levels and causes changes in beta 2m and HLA expression on cell surfaces.	cuprammonium cellulose	28-38	beta-2-microglobulin	Homo sapiens	124-131
2264202-1	1990	The authors studied changes of the beta 2-microglobulin level during hemodialysis with dialyzers AIP-02-02 (cuprophane membrane), E2 (cuprophane membrane), AIP-03-02 (polysulfone membrane), F60 (polysulfone membrane), and hemodiafiltration with dialyzer F60.	cuprammonium cellulose	108-118	beta-2-microglobulin	Homo sapiens	35-55
2264202-1	1990	The authors studied changes of the beta 2-microglobulin level during hemodialysis with dialyzers AIP-02-02 (cuprophane membrane), E2 (cuprophane membrane), AIP-03-02 (polysulfone membrane), F60 (polysulfone membrane), and hemodiafiltration with dialyzer F60.	cuprammonium cellulose	134-144	beta-2-microglobulin	Homo sapiens	35-55
1876284-5	1991	There was a significant (P less than 0.001) platelet activation (beta-thromboglobulin) and combined thrombin/plasmin generation using cuprophane membranes.	cuprammonium cellulose	134-144	coagulation factor II, thrombin	Homo sapiens	100-108
2127434-14	1990	An IL-1-inducing activity was, however, detected in the blood compartment upon dialysis with high permeability membranes, as previously found by others with cuprophan membranes.	cuprammonium cellulose	157-166	interleukin 1 alpha	Homo sapiens	3-7
2252806-6	1990	IL-6 production was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml), and polyacrylonitrile (108 +/- 33 pg/ml) when compared with polystyrole (724 +/- 34 pg/ml).	cuprammonium cellulose	61-70	interleukin 6	Homo sapiens	0-4
2269036-8	1990	A negative correlation was found between delta beta 2m and delta osmolality after HD (r = 0.58, P less than 0.05), but delta beta 2m would be decreasing if a cuprophan membrane dialyzer was reused for HD, and the result was the same if using the same membrane in isolated ultrafiltration (P less than 0.01 in all).	cuprammonium cellulose	158-167	beta-2-microglobulin	Homo sapiens	125-132
2342244-8	1990	The results showed that while the serum exposed to cuprophan membranes contained almost five times more C3a than that exposed to PAN, approximately 80 times more C3a was bound to the PAN membranes.	cuprammonium cellulose	51-60	complement C3	Homo sapiens	104-107
2342244-8	1990	The results showed that while the serum exposed to cuprophan membranes contained almost five times more C3a than that exposed to PAN, approximately 80 times more C3a was bound to the PAN membranes.	cuprammonium cellulose	51-60	complement C3	Homo sapiens	162-165
2342244-9	1990	Consequently, the total amount of C3a generated in the presence of PAN was higher than that generated in the presence of cuprophan.	cuprammonium cellulose	121-130	complement C3	Homo sapiens	34-37
2309101-3	1990	In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-flux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5).	cuprammonium cellulose	103-112	interleukin 1 alpha	Homo sapiens	29-33
2407885-16	1990	Generation of PGE2 and TNF alpha by adherent monocytes induced by cuprophan was C8 dependent: levels were significantly increased by addition of C8 to C8 deficient human serum concomitantly with generation of TCC.	cuprammonium cellulose	66-75	tumor necrosis factor	Homo sapiens	23-32
2309101-3	1990	In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-flux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5).	cuprammonium cellulose	114-116	interleukin 1 alpha	Homo sapiens	29-33
2309101-6	1990	Extracts from unrinsed CU-containing dialysers caused significant IL-1 synthesis and release, whereas incubation with extracts from dialysers containing PS and AN69 sheet membranes did not.	cuprammonium cellulose	23-25	interleukin 1 alpha	Homo sapiens	66-70
2077409-10	1990	Based on these data it seems that the increase in serum beta 2M which has been observed during dialysis with Cuprophan membranes is not caused by direct interaction of lymphocytes with Cuprophan membranes.	cuprammonium cellulose	109-118	beta-2-microglobulin	Homo sapiens	56-63
2240054-6	1990	The generation of interleukin-2 (IL-2) receptor on T lymphocytes after PHA stimulation was normal in the polysulfone-membrane-treated group and slightly impaired in the cuprophane-membrane-dialyzed patients.	cuprammonium cellulose	169-179	interleukin 2	Homo sapiens	18-31
2240054-6	1990	The generation of interleukin-2 (IL-2) receptor on T lymphocytes after PHA stimulation was normal in the polysulfone-membrane-treated group and slightly impaired in the cuprophane-membrane-dialyzed patients.	cuprammonium cellulose	169-179	interleukin 2 receptor subunit beta	Homo sapiens	33-47
2240054-9	1990	The beta 2-microglobulin at levels seen in patients on cuprophane dialysis had no effects on activation and proliferation of control lymphocytes in vitro.	cuprammonium cellulose	55-65	beta-2-microglobulin	Homo sapiens	4-24
2113223-3	1990	After a 240-min haemodialysis, TNF alpha increased on cuprophane (21.95 +/- 3.46 to 37.20 +/- 4.60 pg/ml, P less than 0.001) but remained stable on AN69 (16.70 +/- 2.60 to 19.90 +/- 2.90 pg/ml, NS).	cuprammonium cellulose	54-64	tumor necrosis factor	Homo sapiens	31-40
2113223-9	1990	Our data suggest a net release of TNF alpha during cuprophane but not during polyacrylonitrile haemodialysis.	cuprammonium cellulose	51-61	tumor necrosis factor	Homo sapiens	34-43
2138254-6	1990	ANP clearance across the cuprophan membrane averaged 13 +/- 6.4 ml/mn.	cuprammonium cellulose	25-34	natriuretic peptide A	Homo sapiens	0-3
2198890-1	1990	Cuprophane hemodialysis is associated with an early fall of leukocyte counts and an intradialytic rise in serum beta 2-microglobulin (beta 2M), in contrast to dialysis with more compatible dialyzers.	cuprammonium cellulose	0-10	beta-2-microglobulin	Homo sapiens	112-132
2198890-1	1990	Cuprophane hemodialysis is associated with an early fall of leukocyte counts and an intradialytic rise in serum beta 2-microglobulin (beta 2M), in contrast to dialysis with more compatible dialyzers.	cuprammonium cellulose	0-10	beta-2-microglobulin	Homo sapiens	134-141
2198890-5	1990	Reuse of cuprophane and saponified cellulose ester resulted in a marked attenuation of the intradialytic fall in leukocyte counts after 15 min (change in white blood cell count: -72 and -17% for first-use and third-reuse cuprophane, -72 and -23% for saponified cellulose, respectively), but had no influence on the increase in beta 2M.	cuprammonium cellulose	9-19	beta-2-microglobulin	Homo sapiens	327-334
2198890-6	1990	Correlation studies of these data revealed that the intradialytic evolution of beta 2M was related to membrane pore size and, for membranes with a small pore size, to the intradialytic fluid losses: first-use cuprophane (p less than 0.05), saponified cellulose ester (p less than 0.001) and hemophane (p less than 0.01), and pooled first-use and reuse cuprophane and saponified cellulose ester (p less than 0.001).	cuprammonium cellulose	209-219	beta-2-microglobulin	Homo sapiens	79-86
2198890-6	1990	Correlation studies of these data revealed that the intradialytic evolution of beta 2M was related to membrane pore size and, for membranes with a small pore size, to the intradialytic fluid losses: first-use cuprophane (p less than 0.05), saponified cellulose ester (p less than 0.001) and hemophane (p less than 0.01), and pooled first-use and reuse cuprophane and saponified cellulose ester (p less than 0.001).	cuprammonium cellulose	352-362	beta-2-microglobulin	Homo sapiens	79-86
2198890-8	1990	Ultrafiltration with cuprophane either preceding or following dialysis consistently caused a rise in serum beta 2M, although a fall in leukocyte counts only occurred in the first case.	cuprammonium cellulose	21-31	beta-2-microglobulin	Homo sapiens	107-114
2203684-0	1990	Beta 2-microglobulin serum levels during dialysis: effect of cuprophan and serum osmolality changes.	cuprammonium cellulose	61-70	beta-2-microglobulin	Homo sapiens	0-20
2130295-3	1990	Predialysis C-reactive protein serum values in 17 patients on regular haemodialysis with cuprophan dialysers were greater than those of 18 normal controls (P less than 0.001).	cuprammonium cellulose	89-98	C-reactive protein	Homo sapiens	12-30
2348571-4	1990	Plasma C5a levels were higher in CA and Cu than in EVA.	cuprammonium cellulose	40-42	complement C5a receptor 1	Homo sapiens	7-10