PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17393508-3	2007	We observed that the absorption and lymphatic transport rates of radiolabeled cholesterol and sitostanol were increased by approximately 40% and approximately 500%, respectively, in Abcg8(-/-) mice in the setting of constant intraduodenal infusion of micellar taurocholate and lecithin.	Lecithins	277-285	ATP binding cassette subfamily G member 8	Mus musculus	182-187
18485513-2	2008	Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol.	Lecithins	98-106	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
18485513-2	2008	Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol.	Lecithins	98-106	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
17877144-6	2007	Lecithin treatment significantly reduced AST (32.44%), ALT (32.09%), IL-10 (25.63%) activities and TBARS content (12.76%) compared to ethanol treated group.	Lecithins	0-8	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	41-44
17877144-6	2007	Lecithin treatment significantly reduced AST (32.44%), ALT (32.09%), IL-10 (25.63%) activities and TBARS content (12.76%) compared to ethanol treated group.	Lecithins	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	55-58
17877144-6	2007	Lecithin treatment significantly reduced AST (32.44%), ALT (32.09%), IL-10 (25.63%) activities and TBARS content (12.76%) compared to ethanol treated group.	Lecithins	0-8	interleukin 10	Mus musculus	69-74
17877144-7	2007	However, lecithin with vitamin-B complex treatment, significantly reduced AST (62.83%); ALT (61.96%); IL-10 (35.88%); IFN-gamma (22.55%) activities and TBARS content (31.58%), while significantly elevated GSH content (36.49%) and SOD activity (61.21%).	Lecithins	9-17	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	74-77
17877144-7	2007	However, lecithin with vitamin-B complex treatment, significantly reduced AST (62.83%); ALT (61.96%); IL-10 (35.88%); IFN-gamma (22.55%) activities and TBARS content (31.58%), while significantly elevated GSH content (36.49%) and SOD activity (61.21%).	Lecithins	9-17	glutamic pyruvic transaminase, soluble	Mus musculus	88-91
17877144-7	2007	However, lecithin with vitamin-B complex treatment, significantly reduced AST (62.83%); ALT (61.96%); IL-10 (35.88%); IFN-gamma (22.55%) activities and TBARS content (31.58%), while significantly elevated GSH content (36.49%) and SOD activity (61.21%).	Lecithins	9-17	interleukin 10	Mus musculus	102-107
17877144-7	2007	However, lecithin with vitamin-B complex treatment, significantly reduced AST (62.83%); ALT (61.96%); IL-10 (35.88%); IFN-gamma (22.55%) activities and TBARS content (31.58%), while significantly elevated GSH content (36.49%) and SOD activity (61.21%).	Lecithins	9-17	interferon gamma	Mus musculus	118-127
17344490-7	2007	Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine, SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35).	Lecithins	21-29	acyl-CoA synthetase medium chain family member 3	Homo sapiens	117-120
17344490-7	2007	Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine, SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35).	Lecithins	21-29	acyl-CoA synthetase medium chain family member 3	Homo sapiens	161-164
17085082-0	2007	Response surface methodology for the evaluation of glucose-6-phosphate dehydrogenase enrichment process by soybean lecithin reversed micelles.	Lecithins	115-123	glucose-6-phosphate dehydrogenase	Glycine max	51-84
16327166-6	2005	The hexamers of insulin were dissociated to monomers only by chitosan, polyoxyethylene lauryl ether, and egg lecithin.	Lecithins	109-117	insulin	Homo sapiens	16-23
17237720-0	2007	Dietary lecithin protects against cholestatic liver disease in cholic acid-fed Abcb4- deficient mice.	Lecithins	8-16	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	79-84
16939223-1	2006	Lecithin retinol acyl transferase (LRAT) has the essential role of catalyzing the transfer of an acyl group from the sn-1 position of lecithin to vitamin A to generate all-trans-retinyl esters (tREs).	Lecithins	134-142	lecithin retinol acyltransferase	Homo sapiens	0-33
16939223-1	2006	Lecithin retinol acyl transferase (LRAT) has the essential role of catalyzing the transfer of an acyl group from the sn-1 position of lecithin to vitamin A to generate all-trans-retinyl esters (tREs).	Lecithins	134-142	lecithin retinol acyltransferase	Homo sapiens	35-39
16854325-0	2006	[Effects of lecithin-like oxidized low-density lipoprotein receptor-1 on p38 mitogen-activated protein kinase induced by oxidized low-density lipoprotein in endothelial cells].	Lecithins	12-20	mitogen-activated protein kinase 14	Homo sapiens	73-109
16854325-1	2006	OBJECTIVE: To investigate the effects of lecithin-like oxidized low-density lipoprotein receptor-1 (LOX-1) on the p38 mitogen-activated protein kinase (p38MAPK) induced by oxidized low-density lipoprotein (ox-LDL) in endothelial cells.	Lecithins	41-49	oxidized low density lipoprotein receptor 1	Homo sapiens	100-105
16854325-1	2006	OBJECTIVE: To investigate the effects of lecithin-like oxidized low-density lipoprotein receptor-1 (LOX-1) on the p38 mitogen-activated protein kinase (p38MAPK) induced by oxidized low-density lipoprotein (ox-LDL) in endothelial cells.	Lecithins	41-49	mitogen-activated protein kinase 14	Homo sapiens	114-150
16854325-1	2006	OBJECTIVE: To investigate the effects of lecithin-like oxidized low-density lipoprotein receptor-1 (LOX-1) on the p38 mitogen-activated protein kinase (p38MAPK) induced by oxidized low-density lipoprotein (ox-LDL) in endothelial cells.	Lecithins	41-49	mitogen-activated protein kinase 14	Homo sapiens	152-159
16670775-5	2006	CETP-D HDL-2 caused a 2- to 3-fold stimulation of net cholesterol efflux compared with control HDL-2 in LXR-activated macrophages, due primarily to an increase in lecithin:cholesterol acyltransferase-mediated (LCAT-mediated) cholesteryl ester formation in media.	Lecithins	163-171	cholesteryl ester transfer protein	Homo sapiens	0-6
16670775-5	2006	CETP-D HDL-2 caused a 2- to 3-fold stimulation of net cholesterol efflux compared with control HDL-2 in LXR-activated macrophages, due primarily to an increase in lecithin:cholesterol acyltransferase-mediated (LCAT-mediated) cholesteryl ester formation in media.	Lecithins	163-171	junctophilin 3	Homo sapiens	7-12
15707984-1	2005	The addition of lecithin molecules to brain-derived neurotrophic factor (BDNF) has been reported to markedly enhance its pharmacological effect in vivo.	Lecithins	16-24	brain derived neurotrophic factor	Homo sapiens	38-71
15882068-6	2005	Subsequently, apo A-I forms small ( approximately 5-15 nm) complexes with lecithin and cholesterol that coexist with lipid-stabilized (400-800 nm) DAG oil droplets.	Lecithins	74-82	apolipoprotein A1	Homo sapiens	14-21
15882068-11	2005	A fluorescence assay involving dansylated lecithin shows that the suppression is an indirect effect of apo A-I rather than a direct inhibition of PLC enzyme activity.	Lecithins	42-50	apolipoprotein A1	Homo sapiens	103-110
15707984-1	2005	The addition of lecithin molecules to brain-derived neurotrophic factor (BDNF) has been reported to markedly enhance its pharmacological effect in vivo.	Lecithins	16-24	brain derived neurotrophic factor	Homo sapiens	73-77
15147196-1	2004	Lecithin-retinol acyltransferase (LRAT) catalyzes the transfer of an acyl moiety from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters.	Lecithins	107-115	lecithin retinol acyltransferase	Homo sapiens	0-32
15045164-1	2004	OBJECTIVES: To determine the effect of pretreatment with polyenylphosphatidylcholine (lecithin, PPC) on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, total nitrite/nitrate (NOx), and tissue levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in septic rats.	Lecithins	86-94	tumor necrosis factor	Rattus norvegicus	121-154
15045164-1	2004	OBJECTIVES: To determine the effect of pretreatment with polyenylphosphatidylcholine (lecithin, PPC) on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, total nitrite/nitrate (NOx), and tissue levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in septic rats.	Lecithins	86-94	interleukin 6	Rattus norvegicus	156-174
15147196-1	2004	Lecithin-retinol acyltransferase (LRAT) catalyzes the transfer of an acyl moiety from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters.	Lecithins	107-115	lecithin retinol acyltransferase	Homo sapiens	34-38
15653164-0	2005	Brain-derived neurotrophic factor bound with lecithin derivative showed a markedly enhanced pharmacological potency due to its potent cell membrane affinity followed by prolonged MAPK activation.	Lecithins	45-53	brain derived neurotrophic factor	Mus musculus	0-33
15653164-0	2005	Brain-derived neurotrophic factor bound with lecithin derivative showed a markedly enhanced pharmacological potency due to its potent cell membrane affinity followed by prolonged MAPK activation.	Lecithins	45-53	mitogen-activated protein kinase 1	Mus musculus	179-183
15653164-1	2005	We synthesized lecithinized brain-derived neurotrophic factor (lecithinized-BDNF), in which an average of three molecules of a lecithin derivative were bound to recombinant human BDNF.	Lecithins	15-23	brain derived neurotrophic factor	Homo sapiens	28-61
15653164-1	2005	We synthesized lecithinized brain-derived neurotrophic factor (lecithinized-BDNF), in which an average of three molecules of a lecithin derivative were bound to recombinant human BDNF.	Lecithins	15-23	brain derived neurotrophic factor	Homo sapiens	76-80
15653164-1	2005	We synthesized lecithinized brain-derived neurotrophic factor (lecithinized-BDNF), in which an average of three molecules of a lecithin derivative were bound to recombinant human BDNF.	Lecithins	15-23	brain derived neurotrophic factor	Homo sapiens	179-183
15653164-6	2005	In vitro cell growth activity of lecithinized-BDNF using the MTT assay was lower than unmodified BDNF, probably due to steric hindrance of the lecithin moieties.	Lecithins	33-41	brain derived neurotrophic factor	Mus musculus	46-50
15549448-7	2004	Further, RT-PCR showed that the expressions of Asbt and Mrp3 mRNAs were enhanced by all the bile salts, whereas lecithin reduced Asbt expression, but enhanced Mrp3 expression.	Lecithins	112-120	solute carrier family 10, member 2	Mus musculus	129-133
15549448-7	2004	Further, RT-PCR showed that the expressions of Asbt and Mrp3 mRNAs were enhanced by all the bile salts, whereas lecithin reduced Asbt expression, but enhanced Mrp3 expression.	Lecithins	112-120	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	159-163
15549448-9	2004	In addition, the induction of Mrp3 expression by lecithin may play a role in inhibiting the accumulation of bile.	Lecithins	49-57	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	30-34
15267204-6	2004	The difference of the serum PSA concentration was significant between the prostatitis and the control groups (P < 0.001) as well as between the groups with higher and lower WBC contents in EPS (P < 0.05), but not between the groups with higher (27 patients) and lower (35 patients) lecithin mass contents in EPS (P > 0.05), nor between the groups of bacterial prostatitis and nonbacterial prostatitis (P > 0.05).	Lecithins	288-296	aminopeptidase puromycin sensitive	Homo sapiens	28-31
14596594-1	2003	Lecithin retinol acyltransferase (LRAT) catalyzes the reversible esterification of vitamin A using lecithin as the acyl donor.	Lecithins	99-107	lecithin retinol acyltransferase	Homo sapiens	0-32
15549708-10	2004	Lecithin, alpha-tocopherol and their combination restored MDA content, as well as CAT activity with a slight tendency to normalize SOD activity.	Lecithins	0-8	catalase	Rattus norvegicus	82-85
14729075-6	2003	Apo A-I possibly induces the formation of small apo A-I/lecithin/cholesterol complexes of about 5-20 nm similar to the discoidal pre-HDL complexes found in blood when it can no longer effectively shield all the DAG molecules.	Lecithins	56-64	apolipoprotein A1	Homo sapiens	0-7
14729075-6	2003	Apo A-I possibly induces the formation of small apo A-I/lecithin/cholesterol complexes of about 5-20 nm similar to the discoidal pre-HDL complexes found in blood when it can no longer effectively shield all the DAG molecules.	Lecithins	56-64	apolipoprotein A1	Homo sapiens	48-55
14596594-1	2003	Lecithin retinol acyltransferase (LRAT) catalyzes the reversible esterification of vitamin A using lecithin as the acyl donor.	Lecithins	99-107	lecithin retinol acyltransferase	Homo sapiens	34-38
19003201-5	2003	Supplementation of basal media with phosphatidic acid (PA) from egg yolk lecithin, which has been shown to enhance cell growth and recombinant protein production in serum-free culture of Chinese hamster ovary (CHO) cells, was also effective in increasing beta-galactosidase yield.	Lecithins	73-81	beta-galactosidase	Cricetulus griseus	255-273
12163688-1	2002	In the early 1930s, the group of Banting and Best showed that the choline moiety of lecithin was responsible for the prevention of the fatty livers produced in pancreatectomized dogs treated with insulin.	Lecithins	84-92	insulin	Canis lupus familiaris	196-203
12759133-2	2003	Mechanistic studies showed that expressions in rat liver of Na(+), K(+)-ATPase, Ca(2+), Mg(2+)-ATPase and F-actin were both decreased by drug administration and both enhanced by (n-6) lecithin enriched diet.	Lecithins	184-192	carbonic anhydrase 2	Rattus norvegicus	80-101
12419651-2	2002	In this study, the hypoglycaemic effect of INSULIN BUCCAL SPRAY (IBS), a formulation with soybean lecithin and propanediol combined as absorption enhancer for insulin on diabetic rabbits and rats, were investigated.	Lecithins	98-106	insulin	Oryctolagus cuniculus	43-50
12009892-1	2002	Membrane-bound lecithin retinol acyltransferase (LRAT), an essential enzyme in vitamin A processing, catalyzes the formation of retinyl esters from vitamin A and lecithin.	Lecithins	15-23	lecithin retinol acyltransferase	Homo sapiens	49-53
11231005-1	2001	Lecithin retinol acyl transferase (LRAT) is a novel membrane bound enzyme that catalyzes the formation of retinyl esters from vitamin A and lecithin.	Lecithins	140-148	lecithin retinol acyltransferase	Homo sapiens	0-33
12051518-1	2002	The enzyme lecithin-cholesterol acyltransferase (LCAT) transfers an acyl chain from lecithin to cholesterol or oestradiol, thus playing a crucial role in reverse cholesterol transport and follicular synthesis of potent long-lived oestrogens.	Lecithins	11-19	lecithin-cholesterol acyltransferase	Homo sapiens	49-53
11478786-5	2001	Myocardial infarct area assessed by TTC staining was smaller in lecithinized SOD group than PEG-SOD, unmodified SOD, free lecithin derivative or control group.	Lecithins	64-72	superoxide dismutase 1	Homo sapiens	77-80
11231005-1	2001	Lecithin retinol acyl transferase (LRAT) is a novel membrane bound enzyme that catalyzes the formation of retinyl esters from vitamin A and lecithin.	Lecithins	140-148	lecithin retinol acyltransferase	Homo sapiens	35-39
11111093-2	2000	LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins.	Lecithins	77-86	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
9580110-4	1998	A possible mechanism of the pro-atherogenic action of human apoA-II could be the inhibition of reverse cholesterol transport and, in support of this, we observed an impairment of apoA-I-HDL particle interconversion in the plasma of 11.1 transgenic mice caused, at least in part, by a marked decrease in the endogenous lecithin:cholesterol acyltransferase activity.	Lecithins	318-326	apolipoprotein A2	Homo sapiens	60-67
11052698-0	2000	Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation.	Lecithins	81-89	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-108
9848889-4	1998	Lecithin preexisting on the surface of oil droplets reduces significantly the amount of fibrinogen that can otherwise bind to them.	Lecithins	0-8	fibrinogen beta chain	Homo sapiens	88-98
9742684-2	1998	Spin-labeled stearic acid is used both to provide the carboxyl groups and to monitor binding and ionization behavior in egg lecithin liposomes.	Lecithins	124-132	spindlin 1	Homo sapiens	0-4
9600659-1	1998	Lecithinized superoxide dismutase, a lecithin derivative bound to recombinant human CuZn superoxide dismutase, has a higher affinity for cells such as polymorphonuclear leukocytes and endothelial cells than recombinant human CuZn superoxide dismutase has.	Lecithins	37-45	superoxide dismutase 1	Homo sapiens	84-109
9600659-1	1998	Lecithinized superoxide dismutase, a lecithin derivative bound to recombinant human CuZn superoxide dismutase, has a higher affinity for cells such as polymorphonuclear leukocytes and endothelial cells than recombinant human CuZn superoxide dismutase has.	Lecithins	37-45	superoxide dismutase 1	Homo sapiens	225-250
10487497-1	1999	Lecithin: cholesterolacyltransferase (LCAT) transacylates the fatty acid at the sn-2 position of lecithin to the 3beta-OH group of cholesterol forming lysolecithin and the majority of cholesteryl ester found in plasma.	Lecithins	97-105	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
10487497-1	1999	Lecithin: cholesterolacyltransferase (LCAT) transacylates the fatty acid at the sn-2 position of lecithin to the 3beta-OH group of cholesterol forming lysolecithin and the majority of cholesteryl ester found in plasma.	Lecithins	97-105	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
10546279-1	1999	A simple and convenient method of simultaneous determinations of effects of any set of chemical compounds on enzymatic hydrolysis of phospholipids by using the method of diffusion phospholipase A2 in a lecithin-agarose gel.	Lecithins	202-210	phospholipase A2 group IB	Homo sapiens	180-196
10024228-11	1998	In the soy lecithin, the detection rate of only one protein, with a molecular weight of 31 kDa, by the serum IgE of patients was significantly different compared with controls (detection rate: 40%).	Lecithins	11-19	immunoglobulin heavy constant epsilon	Homo sapiens	109-112
9580110-4	1998	A possible mechanism of the pro-atherogenic action of human apoA-II could be the inhibition of reverse cholesterol transport and, in support of this, we observed an impairment of apoA-I-HDL particle interconversion in the plasma of 11.1 transgenic mice caused, at least in part, by a marked decrease in the endogenous lecithin:cholesterol acyltransferase activity.	Lecithins	318-326	apolipoprotein A1	Homo sapiens	60-66
8995259-0	1997	Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.	Lecithins	26-34	phospholipase A2 group IB	Homo sapiens	74-90
9273884-0	1997	A binding study of phospholipase A2 with lecithin, lysolecithin and their tetrahedral intermediates using molecular modeling.	Lecithins	41-49	phospholipase A2 group IB	Homo sapiens	19-35
9273884-1	1997	We used molecular modeling to examine the binding of 1,2-dioctanoyl-sn-glycero-3-phosphocholine (a lecithin), 1-octanoyl-sn-glycero-3-phosphocholine (a lysolecithin) and their tetrahedral intermediates in the catalytic site of phospholipase A2 (PLA2).	Lecithins	99-107	phospholipase A2 group IB	Homo sapiens	227-243
9273884-1	1997	We used molecular modeling to examine the binding of 1,2-dioctanoyl-sn-glycero-3-phosphocholine (a lecithin), 1-octanoyl-sn-glycero-3-phosphocholine (a lysolecithin) and their tetrahedral intermediates in the catalytic site of phospholipase A2 (PLA2).	Lecithins	99-107	phospholipase A2 group IB	Homo sapiens	245-249
9273884-3	1997	We found that the calculated orientation of the sn-1 ester bond of lysolecithin in the active site is similar to that of the sn-2 ester bond in lecithin, thus permitting PLA2 to hydrolyze lysolecithin using the same mechanism as it uses to hydrolyze lecithin.	Lecithins	71-79	phospholipase A2 group IB	Homo sapiens	170-174
9273884-3	1997	We found that the calculated orientation of the sn-1 ester bond of lysolecithin in the active site is similar to that of the sn-2 ester bond in lecithin, thus permitting PLA2 to hydrolyze lysolecithin using the same mechanism as it uses to hydrolyze lecithin.	Lecithins	144-152	phospholipase A2 group IB	Homo sapiens	170-174
8819172-1	1996	alpha-Lactalbumin (alpha-LA) associates with dimyristoylphosphatidylcholine (DMPC) or egg lecithin (EPC) liposomes.	Lecithins	90-98	lactalbumin alpha	Homo sapiens	0-17
9080662-0	1997	Combined effect of a lecithin and a bile salt on pancreatic lipase activity.	Lecithins	21-29	pancreatic lipase	Homo sapiens	49-66
8819172-1	1996	alpha-Lactalbumin (alpha-LA) associates with dimyristoylphosphatidylcholine (DMPC) or egg lecithin (EPC) liposomes.	Lecithins	90-98	lactalbumin alpha	Homo sapiens	19-27
7548172-12	1995	We conclude that LCAT can transacylate a fatty acyl moiety from the sn-2 position of lecithin to the 3 beta-SH group of thiocholesterol forming a cholesteryl thioester.	Lecithins	85-93	lecithin-cholesterol acyltransferase	Homo sapiens	17-21
23194616-6	1996	Elevated under the influence of lecithin, the content of cytochrome P-450 in the liver microsomes was shown.	Lecithins	32-40	cytochrome P-450	Oryctolagus cuniculus	57-73
8894803-2	1996	Lecithin-bound iodine (LBI), which has been used as a therapeutic modality for patients with bronchial asthma (BA), effectively inhibited Dermatophagoides farinae (Df) mite antigen-induced IL-2 responsiveness in concentrations comparable to LBI concentrations in blood.	Lecithins	0-8	interleukin 2	Homo sapiens	189-193
8866628-4	1996	Neither drug altered lipoprotein core lipid composition, but small increases were observed in the HDL2 sphingomyelin/lecithin ratio after both agents.	Lecithins	117-125	junctophilin 3	Homo sapiens	98-102
7548172-2	1995	Lecithin:cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyses cholesteryl ester formation from lecithin and cholesterol present in the surface of plasma lipoproteins.	Lecithins	112-120	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
7548172-2	1995	Lecithin:cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyses cholesteryl ester formation from lecithin and cholesterol present in the surface of plasma lipoproteins.	Lecithins	112-120	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
7548172-5	1995	In order to assess the ability of LCAT to donate a fatty acid derived from the sn-2 position of lecithin and present as an acyl enzyme intermediate (linked via an oxyester bond to Ser-181) to a sulfhydryl residue, we evaluated the ability of cholest-5-ene-3 beta-thiol to act as a substrate for cholesterol ester formation by LCAT.	Lecithins	96-104	lecithin-cholesterol acyltransferase	Homo sapiens	34-38
7734012-2	1994	The MDR1 Pgp can transport drugs; the murine homologue of MDR3, mdr2, was recently shown by us to be involved in transport of the phospholipid phosphatidylcholine (lecithin) into bile.	Lecithins	164-172	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	4-8
7773735-1	1995	Fibrinogen, the precursor of the blood clot matrix and a major constituent of atherosclerotic lesions, is shown to adsorb with high affinity to hydrophobic beads coated with cholesteryl oleate, cholesterol, or loosely packed lecithin.	Lecithins	225-233	fibrinogen beta chain	Homo sapiens	0-10
7773735-4	1995	Not unexpectedly, the quantity of fibrinogen that binds to beads coated with mixtures of cholesteryl oleate and lecithin increases with increasing concentration of the cholesteryl ester.	Lecithins	112-120	fibrinogen beta chain	Homo sapiens	34-44
7748973-6	1995	Prolidase I activity was positively correlated with lecithin levels (n = 30; r = 0.42; p < 0.02), and also with birth weight of the babies (n = 30; r = 0.52; p < 0.01) in the term-mature group.	Lecithins	52-60	peptidase D	Homo sapiens	0-9
7961983-4	1994	LCAT cofactor activity decreased by 90 and 75%, respectively, when egg lecithin or palmitoyloleoylphosphatidylcholine was used to form the particles with the delta aa 117-160 mutant.	Lecithins	71-79	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
8652960-6	1995	The efficient clearing of 20% Intralipid might be related to the lower lecithin: triglyceride ration which is compatible with the low LCAT activity of premature infants.	Lecithins	71-79	lecithin-cholesterol acyltransferase	Homo sapiens	134-138
7773735-2	1995	The quantity of fibrinogen that binds to cholesterol- or lecithin-coated beads decreases as the surface concentration of the lipid increases; densely packed films lecithin bind little,if any, if the protein.	Lecithins	57-65	fibrinogen beta chain	Homo sapiens	16-26
7742325-6	1995	Best results were obtained when hTfR was dissolved with octylpolyoxyethylene, mixed with detergent-solubilized soy bean lecithin, and reconstituted by slow dialysis.	Lecithins	120-128	transferrin receptor	Homo sapiens	32-36
7629727-0	1995	Preparation and characterization of fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles.	Lecithins	76-84	fibrinogen beta chain	Homo sapiens	36-46
7629727-1	1995	We have developed a method for producing fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles.	Lecithins	81-89	fibrinogen beta chain	Homo sapiens	41-51
7734012-2	1994	The MDR1 Pgp can transport drugs; the murine homologue of MDR3, mdr2, was recently shown by us to be involved in transport of the phospholipid phosphatidylcholine (lecithin) into bile.	Lecithins	164-172	phosphoglycolate phosphatase	Mus musculus	9-12
7734012-2	1994	The MDR1 Pgp can transport drugs; the murine homologue of MDR3, mdr2, was recently shown by us to be involved in transport of the phospholipid phosphatidylcholine (lecithin) into bile.	Lecithins	164-172	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	58-62
7734012-2	1994	The MDR1 Pgp can transport drugs; the murine homologue of MDR3, mdr2, was recently shown by us to be involved in transport of the phospholipid phosphatidylcholine (lecithin) into bile.	Lecithins	164-172	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	64-68
8039258-4	1994	The data obtained here indicate that in lecithins containing the same acyl chain in sn-1 and sn-2, the introduction of double bonds towards the deep interior of the lipid bilayer decreases the order in the external region of the bilayer and the viscous resistance to the rotation of all the probes tested.	Lecithins	40-49	solute carrier family 38 member 3	Homo sapiens	84-88
8039258-4	1994	The data obtained here indicate that in lecithins containing the same acyl chain in sn-1 and sn-2, the introduction of double bonds towards the deep interior of the lipid bilayer decreases the order in the external region of the bilayer and the viscous resistance to the rotation of all the probes tested.	Lecithins	40-49	solute carrier family 38 member 5	Homo sapiens	93-97
8282802-0	1994	Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.	Lecithins	125-133	apolipoprotein A2	Homo sapiens	56-63
8282802-0	1994	Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.	Lecithins	125-133	apolipoprotein A2	Homo sapiens	106-113
8134196-6	1994	Surfactant apoprotein A concentration and lecithin to sphingomyelin ratio were both significantly higher in the amniotic fluid of the EGF-treated group, indicating advanced biochemical maturation in this group of animals.	Lecithins	42-50	epidermal growth factor	Homo sapiens	134-137
8279971-0	1993	[Analysis of immunosuppressive activity of lecithin-bound iodine (LBI) on antigen-induced IL2 responsiveness in peripheral blood lymphocytes from patients with allergic diseases].	Lecithins	43-51	interleukin 2	Homo sapiens	90-93
24234896-1	1993	The interaction between zinc-stabilized insulin and lecithin liposomal membranes was studied using DPH fluorescence anisotropy and light-scattering techniques.	Lecithins	52-60	insulin	Homo sapiens	40-47
24234896-3	1993	Measurements at pH 4.5 revealed significant changes in scattered light intensity induced by the addition of insulin to lecithin liposomes.	Lecithins	119-127	insulin	Homo sapiens	108-115
8279971-1	1993	The effect of lecithin-bound iodine (LBI) on antigen-induced IL2 responsiveness, useful in in vitro test for the detection of etiological antigen and disease activity in allergic diseases, was investigated.	Lecithins	14-22	interleukin 2	Homo sapiens	61-64
8394971-8	1993	These findings suggest that: 1) abnormalities in the extrahypothalamic CRH system play a role in the pathophysiology of senile dementia, which may not be specific to SDAT; 2) the CRH system and the ACTH system correlate with each other within the brain; 3) CSF ACTH is subject to the feedback inhibition by circulating cortisol; and 4) in the SDAT patients and the severe dementia group CSF CRH and serum lecithin are reduced probably via independent mechanisms.	Lecithins	405-413	corticotropin releasing hormone	Homo sapiens	71-74
8457568-1	1993	Lecithin retinol acyltransferase (LRAT) transfers acyl groups regiospecifically from the sn-1 position of lecithins to all-trans-retinol (vitamin A) and similar retinoids.	Lecithins	106-115	lecithin retinol acyltransferase	Homo sapiens	0-32
8457568-1	1993	Lecithin retinol acyltransferase (LRAT) transfers acyl groups regiospecifically from the sn-1 position of lecithins to all-trans-retinol (vitamin A) and similar retinoids.	Lecithins	106-115	lecithin retinol acyltransferase	Homo sapiens	34-38
8422362-1	1993	The kinetics of binding of a glycolipid-anchored protein (the promastigote surface protease, PSP) to planar lecithin bilayers is studied by an integrated optics technique, in which the bilayer membrane is supported on an optical wave guide and the phase velocities of guided light modes in the wave guide are measured.	Lecithins	108-116	microseminoprotein beta	Homo sapiens	93-96
8412112-0	1993	Effect of mixing ratio in lecithin/bile acid mixed micelles on Na(+)-K+ ATPase.	Lecithins	26-34	dynein axonemal heavy chain 8	Homo sapiens	72-78
8412112-2	1993	We found that the mixing ratio in lecithin/bile acid mixed micelles directly changes the activity of Na(+)-K+ ATPase.	Lecithins	34-42	dynein axonemal heavy chain 8	Homo sapiens	110-116
8412112-3	1993	Na(+)-K+ ATPase activity was suppressed to 13.3% of that in the buffer alone at a lecithin/bile acid mixing ratio of 0.1 in the presence of 10(-2) M bile acid (that is, a concentration level close to that of the hepatic bile).	Lecithins	82-90	dynein axonemal heavy chain 8	Homo sapiens	9-15
8412112-6	1993	If lecithin addition is made in the presence of bile acid at the near gallbladder concentration of 10(-1) M, however, the Na(+)-K+ ATPase activity can be observed to increase with the increase in the lecithin/bile acid ratio.	Lecithins	3-11	dynein axonemal heavy chain 8	Homo sapiens	131-137
8412112-6	1993	If lecithin addition is made in the presence of bile acid at the near gallbladder concentration of 10(-1) M, however, the Na(+)-K+ ATPase activity can be observed to increase with the increase in the lecithin/bile acid ratio.	Lecithins	200-208	dynein axonemal heavy chain 8	Homo sapiens	131-137
8326012-3	1993	In contrast to previously reported patients with FED who are unable to esterify HDL-associated cholesterol, our patients" plasma lecithin-cholesterol acetyltransferase (alpha-LCAT)-specific activities assayed using an HDL-like proteoliposome substrate were 12.7-25.7 nmol/micrograms (19.5 +/- 1.8 in controls).	Lecithins	129-137	lecithin-cholesterol acyltransferase	Homo sapiens	175-179
8485868-2	1993	On the basis of a position-specific fatty acid analysis of the natural substrate ("soybean lecithin") from a commercial PLA kit, serum activities of PLA1 could be clearly distinguished from those of PLA2, which is not possible in the usual measurements made with single-label radioactive substrates.	Lecithins	91-99	phospholipase A and acyltransferase 1	Homo sapiens	120-123
8485868-2	1993	On the basis of a position-specific fatty acid analysis of the natural substrate ("soybean lecithin") from a commercial PLA kit, serum activities of PLA1 could be clearly distinguished from those of PLA2, which is not possible in the usual measurements made with single-label radioactive substrates.	Lecithins	91-99	POU class 2 homeobox 3	Homo sapiens	149-153
8504798-1	1993	The cytoskeletal component vinculin has been demonstrated by hydrophobic photoradiolabelling, to insert into bilayers containing acidic phospholipids and trace amounts of a photoactivatable analogue of lecithin.	Lecithins	202-210	vinculin	Homo sapiens	27-35
1634549-15	1992	Lysolecithin (25 and 100 microM), but not lecithin, monoglycerides, or diglycerides, released adipocyte surface LPL.	Lecithins	4-12	lipoprotein lipase	Homo sapiens	112-115
8393544-9	1993	The resulting reduction in LCAT activity may lead to the accumulation of cholesterol and lecithin in cell membranes and contribute to the overall pathophysiology of renal disease.	Lecithins	89-97	lecithin-cholesterol acyltransferase	Homo sapiens	27-31
1644835-11	1992	Electron microscopy of the proteoliposome LCAT substrate generated by WT and mutant apoA-I forms showed that the carboxyl-terminal deletion mutants which displayed aberrant binding to HDL also displayed reduced ability to convert the spherical lecithin-cholesterol vesicles into discs compared with WT.	Lecithins	244-252	lecithin-cholesterol acyltransferase	Homo sapiens	42-46
1644835-11	1992	Electron microscopy of the proteoliposome LCAT substrate generated by WT and mutant apoA-I forms showed that the carboxyl-terminal deletion mutants which displayed aberrant binding to HDL also displayed reduced ability to convert the spherical lecithin-cholesterol vesicles into discs compared with WT.	Lecithins	244-252	apolipoprotein A1	Homo sapiens	84-90
1479517-1	1992	The determination of lecithin or even more the lecithin/sphingomyelin (L/S) ratio in amniotic fluid are both well established in the prediction of neonatal RDS.	Lecithins	21-29	peripherin 2	Homo sapiens	156-159
1581331-0	1992	Spontaneous domain formation of phospholipase A2 at interfaces: fluorescence microscopy of the interaction of phospholipase A2 with mixed monolayers of lecithin, lysolecithin and fatty acid.	Lecithins	152-160	phospholipase A2 group IB	Homo sapiens	32-48
1581331-0	1992	Spontaneous domain formation of phospholipase A2 at interfaces: fluorescence microscopy of the interaction of phospholipase A2 with mixed monolayers of lecithin, lysolecithin and fatty acid.	Lecithins	152-160	phospholipase A2 group IB	Homo sapiens	110-126
1479517-1	1992	The determination of lecithin or even more the lecithin/sphingomyelin (L/S) ratio in amniotic fluid are both well established in the prediction of neonatal RDS.	Lecithins	47-55	peripherin 2	Homo sapiens	156-159
1805157-1	1991	Surfactant proteins A and B (SP-A and SP-B) were measured in human amniotic fluid by ELISA and correlated with lecithin to sphingomyelin ratio (L/S), phosphatidylglycerol (PG), and perinatal outcome.	Lecithins	111-119	surfactant protein A1	Homo sapiens	0-27
1856575-5	1991	Moreover, their very-low-density lipoprotein (VLDL) and HDL2 tended to have reduced amounts of free (unesterified) cholesterol (FC) relative to lecithin, and their HDL2 and HDL3 tended to be triglyceride enriched.	Lecithins	144-152	junctophilin 3	Homo sapiens	56-60
1919954-1	1991	Plasma cholesterol and lecithin concentrations are regulated by the serum enzyme lecithin: cholesterol acyltransferase (LCAT).	Lecithins	23-31	lecithin-cholesterol acyltransferase	Homo sapiens	81-118
1770112-2	1991	Lecithin, the substrate for PLC, was ligated hydrophobically to octyl-Sepharose in 2 M (NH4)2SO4.	Lecithins	0-8	heparan sulfate proteoglycan 2	Homo sapiens	28-31
1770112-3	1991	The washed lecithin-conjugated resin was then used to purify PLC from crude preparations by affinity chromatography.	Lecithins	11-19	heparan sulfate proteoglycan 2	Homo sapiens	61-64
1919954-1	1991	Plasma cholesterol and lecithin concentrations are regulated by the serum enzyme lecithin: cholesterol acyltransferase (LCAT).	Lecithins	23-31	lecithin-cholesterol acyltransferase	Homo sapiens	120-124
1663404-8	1991	Simulations of 31P-NMR resonance linewidth of oriented multibilayers of PAF/egg lecithin mixtures indicate a rippled structure which accounts for the perturbed distribution of the local director observed by ESR spin probe measurements.	Lecithins	80-88	PCNA clamp associated factor	Homo sapiens	72-75
2059596-4	1991	The tap test was also more reliable in identifying fetuses with borderline lecithin/sphingomyelin ratios in the range 3.2-3.7:1.	Lecithins	75-83	nuclear RNA export factor 1	Homo sapiens	4-7
2252889-2	1990	We studied the interaction of transferrin receptors (of cell line Molt-4) with mixed model membranes as a function of lipid chain length (phospholipids with C14:0 and C18:1 hydrocarbon chains) and of the surface charge of the membrane using mixtures of C14:0 lecithin (DMPC) with C14:0 phosphatidylglycerol (DMPG) and C14:0 phosphatidylserine (DMPS).	Lecithins	259-267	transferrin	Homo sapiens	30-41
1714413-1	1991	The interaction of angiotensin II (ANG II) with membrane was studied by measuring conductance and current-voltage characteristics (IVC) of bilayer lipid membranes (BLM) prepared of a mixture of egg lecithin with cholesterol, and of gramicidin D-modified membranes of the same composition.	Lecithins	198-206	angiotensinogen	Homo sapiens	19-33
1714413-1	1991	The interaction of angiotensin II (ANG II) with membrane was studied by measuring conductance and current-voltage characteristics (IVC) of bilayer lipid membranes (BLM) prepared of a mixture of egg lecithin with cholesterol, and of gramicidin D-modified membranes of the same composition.	Lecithins	198-206	angiotensinogen	Homo sapiens	35-41
2211707-6	1990	We conclude that apoA-IV-2 has more alpha-helical structure, is more stable in solution, and is more hydrophobic than apoA-IV-1, and that these distinctive structural features are associated with a higher affinity for phospholipid surfaces and an increased catalytic efficiency of lecithin:cholesterol acyltransferase activation.	Lecithins	281-289	apolipoprotein A4	Homo sapiens	17-24
1649652-0	1991	[Myeloperoxidase interaction with mixed monolayers of lecithin and cholesterol].	Lecithins	54-62	myeloperoxidase	Homo sapiens	1-16
24271177-2	2014	LL medium includes lecithin from soybeans for the detection of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) produced by L. monocytogenes.	Lecithins	19-27	phosphatidylinositol-specific phospholipase C	Glycine max	63-108
2210647-5	1990	Mucin contains domains that bind cholesterol and lecithin transported as vesicles in supersaturated bile.	Lecithins	49-57	LOC100508689	Homo sapiens	0-5
2115332-2	1990	Only PLA2 activity was increased by DPPC, suggesting that lecithin, the major surfactant component, increases the PGE production of the amniotic membrane by activating PLA2.	Lecithins	58-66	phospholipase A2 group IB	Homo sapiens	5-9
2115332-2	1990	Only PLA2 activity was increased by DPPC, suggesting that lecithin, the major surfactant component, increases the PGE production of the amniotic membrane by activating PLA2.	Lecithins	58-66	phospholipase A2 group IB	Homo sapiens	168-172
2370048-1	1990	The enzyme, lecithin cholesterol acyltransferase (LCAT), is responsible for the esterification of plasma cholesterol mediating the transfer of an acyl group from lecithin to the 3-hydroxy group of cholesterol.	Lecithins	12-20	lecithin-cholesterol acyltransferase	Homo sapiens	50-54
2372545-1	1990	Size-exclusion high-performance liquid chromatography with a TSK 5000 PW column was shown to be a fast and relatively inexpensive method for the size determination of lecithin-bile salt mixed micelles.	Lecithins	167-175	tsukushi, small leucine rich proteoglycan	Homo sapiens	61-64
2406238-2	1990	Lecithin-cholesterol acyltransferase (LCAT) catalyzes the intravascular synthesis of lipoprotein cholesteryl esters by converting cholesterol and lecithin to cholesteryl ester and lysolecithin.	Lecithins	146-154	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
2406238-2	1990	Lecithin-cholesterol acyltransferase (LCAT) catalyzes the intravascular synthesis of lipoprotein cholesteryl esters by converting cholesterol and lecithin to cholesteryl ester and lysolecithin.	Lecithins	146-154	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
2406238-10	1990	Addition of excess lysolecithin to the incubation system did not result in the formation of [14C]oleate-labeled lecithin, showing that the reverse reaction found here for LCAT was limited to the last step of the reaction.	Lecithins	23-31	lecithin-cholesterol acyltransferase	Homo sapiens	171-175
24271177-2	2014	LL medium includes lecithin from soybeans for the detection of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphatidylcholine-specific phospholipase C (PC-PLC) produced by L. monocytogenes.	Lecithins	19-27	phosphatidylinositol-specific phospholipase C	Glycine max	110-116
34639136-0	2021	Lecithin Inclusion by alpha-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.	Lecithins	0-8	sterol regulatory element binding factor 2	Mus musculus	51-57
34798283-9	2022	Our findings suggest that BET and PSB are outstanding wound healing drugs and their incorporation into lecithin-based NEs may represent a valid strategy for wound care.	Lecithins	103-111	delta/notch like EGF repeat containing	Homo sapiens	26-29
34623203-5	2021	Successful interaction between CS, sodium tripolyphosphate (TPP) and lecithin was confirmed by Fourier-transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction.	Lecithins	69-77	citrate synthase	Rattus norvegicus	31-33
34718875-0	2021	Phospholipids dock SARS-CoV-2 spike protein via hydrophobic interactions: a minimal in-silico study of lecithin nasal spray therapy.	Lecithins	103-111	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-35
34639136-5	2021	Furthermore, oral alpha-CD administration disrupts lipid micelle formation through its inclusion of lecithin in the gut luminal fluid.	Lecithins	100-108	adrenocortical dysplasia	Mus musculus	18-26
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	adrenocortical dysplasia	Mus musculus	32-40
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	adrenocortical dysplasia	Mus musculus	107-115
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	sterol regulatory element binding factor 2	Mus musculus	192-198
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	low density lipoprotein receptor	Mus musculus	213-217
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	219-224
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	proprotein convertase subtilisin/kexin type 9	Mus musculus	226-231
34639136-6	2021	Importantly, prior inclusion of alpha-CD with lecithin in vitro nullified the anti-hyperglycemic effect of alpha-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).	Lecithins	46-54	sterol regulatory element binding factor 2	Mus musculus	237-243
34639136-7	2021	CONCLUSIONS: alpha-CD elicits its anti-hyperglycemic effect after glucose loading by inducing lecithin inclusion in the gut lumen and activating SREBP2, which is known to induce cholecystokinin secretion to suppress hepatic glucose production via a gut/brain/liver axis.	Lecithins	94-102	adrenocortical dysplasia	Mus musculus	13-21
34573503-7	2021	In the lipid metabolism, broilers in the lecithin treatment group showed a significant increase in hepatic lipase and general esterase values at 21 days compared with the control group (p < 0.05).	Lecithins	41-49	lipase C, hepatic type	Homo sapiens	99-113
34140769-1	2021	Purpose: This study was aimed at developing the trispecific antibodies (anti-EGFR/anti-FAP/anti-mPEG, TsAb) or dual bispecific antibodies (anti-EGFR/anti-mPEG and anti-FAP/anti-mPEG) docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micelles (mPEG-lsbPMs) for improving the targeting efficiency and therapeutic efficacy.	Lecithins	217-225	epidermal growth factor receptor	Homo sapiens	144-148
2914888-2	1989	Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyzes the transacylation of the sn-2-fatty acid of lecithin to cholesterol, forming lysolecithin and cholesteryl ester.	Lecithins	124-132	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
2597225-5	1989	Among the other potentially beneficial actions observed was an increase in HDL2 in all patients (mean increment 41%, P less than 0.005), and an increase in the HDL2/HDL3 ratio (+46%, P less than 0.001) and decreases in the LDL/HDL ratio (-14%, P less than 0.005) and in the unesterified cholesterol/lecithin ratio (-17%; P less than 0.001) in plasma.	Lecithins	299-307	junctophilin 3	Homo sapiens	160-164
2753202-1	1989	In this study the relative affinities of natural lecithins and slightly modified lecithin analogues to the active site of porcine pancreatic phospholipase A2 were determined.	Lecithins	49-58	phospholipase A2 group IB	Homo sapiens	141-157
2753202-1	1989	In this study the relative affinities of natural lecithins and slightly modified lecithin analogues to the active site of porcine pancreatic phospholipase A2 were determined.	Lecithins	49-57	phospholipase A2 group IB	Homo sapiens	141-157
35464721-11	2022	Results indicated that the optimal formulation of GSL used soybean lecithin (SPC) as the phospholipid, with a lipid-drug ratio of 1:0.4 and a phospholipid-cholesterol ratio of 1:3.5.	Lecithins	67-75	cathepsin A	Homo sapiens	50-53
2742824-1	1989	3-Hydroxybutyrate dehydrogenase (BDH) is a lecithin-requiring mitochondrial enzyme which catalyzes the interconversion of 3-hydroxybutyrate and acetoacetate with NAD(H) as coenzyme.	Lecithins	43-51	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	33-36
2742824-4	1989	For both models, activation of BDH is assumed to require the binding of two lecithin molecules per functional unit.	Lecithins	76-84	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	31-34
2914888-2	1989	Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyzes the transacylation of the sn-2-fatty acid of lecithin to cholesterol, forming lysolecithin and cholesteryl ester.	Lecithins	124-132	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
2541796-0	1989	Influence of PAF-acether on lecithin-oriented multibilayers monitored by ESR: interaction of PAF-acether with cholesterol.	Lecithins	28-36	PCNA clamp associated factor	Homo sapiens	13-16
3205630-3	1988	Amniotic fluid SP-A concentrations increased as a function of gestational age, from less than 3 micrograms/ml at 30-31 wk to 24 micrograms/ml at 40-41 wk, and were positively correlated with the lecithin to sphingomyelin ratio (p less than 0.01).	Lecithins	195-203	surfactant protein A1	Homo sapiens	15-19
2737544-0	1989	Studies on amniotic prolactin: chromatographic pattern and correlation with the lecithin content.	Lecithins	80-88	prolactin	Homo sapiens	20-29
2737544-2	1989	Prolactin is present totally as a low-molecular-weight form, "little" prolactin, and appears to correlate negatively with lecithin during the 2nd and positively during the 3rd trimester.	Lecithins	122-130	prolactin	Homo sapiens	0-9
2477617-1	1989	A method for measuring the activity of the red cell endogenous phospholipase A is suggested, consisting in red cell destruction, extraction of erythrocytic phospholipase, and detection of the enzymic activity by phosphatidylcholine hydrolysis in the organic phase from the degree of clarification of the lecithin emulsion.	Lecithins	304-312	phospholipase A and acyltransferase 1	Homo sapiens	63-78
3263045-4	1988	In groups matched by gestational age, larger mean values of corticotropin-releasing hormone and cortisol were observed in the group in which the lecithin/sphingomyelin ratio was greater than 2 or the phosphatidylglycerol test was positive than in the group with a lecithin/sphingomyelin ratio less than 2 or a negative phosphatidylglycerol test result.	Lecithins	145-153	corticotropin releasing hormone	Homo sapiens	60-91
3263045-4	1988	In groups matched by gestational age, larger mean values of corticotropin-releasing hormone and cortisol were observed in the group in which the lecithin/sphingomyelin ratio was greater than 2 or the phosphatidylglycerol test was positive than in the group with a lecithin/sphingomyelin ratio less than 2 or a negative phosphatidylglycerol test result.	Lecithins	264-272	corticotropin releasing hormone	Homo sapiens	60-91
3206195-1	1988	The present study was undertaken to determine the relationship between plasma lecithin: cholesterol acyl transfer (LCAT) rate and cholesterol and bile acid turnover in hyperlipidaemia.	Lecithins	78-86	lecithin-cholesterol acyltransferase	Homo sapiens	115-119
3130102-9	1988	Only the best penetrating mutant, viz., porcine phospholipase A2 having a palmitoyl moiety at Lys116, was able to cause complete leakage of 6-carboxyfluorescein entrapped in small unilamellar vesicles of egg lecithin under nonhydrolytic conditions.	Lecithins	208-216	LOC104974671	Bos taurus	48-64
3195851-3	1988	By the fifth day of life, the patients who received CDP-choline required oxygen for a longer period of time, and had a lower lecithin/sphingomyelin ratio and palmitic acid percentage than those in the control group.	Lecithins	125-133	cut like homeobox 1	Homo sapiens	52-55
3129428-2	1988	Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyzes the transacylation of the fatty acid at the sn-2 position of lecithin to cholesterol forming lysolecithin and cholesteryl ester.	Lecithins	140-148	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
3129428-2	1988	Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyzes the transacylation of the fatty acid at the sn-2 position of lecithin to cholesterol forming lysolecithin and cholesteryl ester.	Lecithins	140-148	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
3130102-10	1988	Similarly, only this latter palmitoylphospholipase A2 completely hydrolyzed all lecithin in the outer monolayer of the human erythrocyte at a rate much faster than Naja naja phospholipase A2, the most powerful penetrating snake venom enzyme presently known.	Lecithins	80-88	LOC104974671	Bos taurus	37-53
2442186-8	1987	Significant negative correlations were found between the levels of both BP-28 and BP-53 and the lecithin to sphingomyelin ratio, suggesting an association between the levels of both proteins and the degree of fetal maturity.	Lecithins	96-104	BP28	Homo sapiens	72-77
3126801-0	1987	Formation of mixed micelles and vesicles of human apolipoproteins A-I and A-II with synthetic and natural lecithins and the bile salt sodium taurocholate: quasi-elastic light scattering studies.	Lecithins	106-115	apolipoprotein A1	Homo sapiens	50-78
3448106-5	1987	Milk fat percentage and milk fat yield were greater during soy lecithin infusion (3.54%, 1.11 kg/d) than during water (3.09%, .98 kg/d) or soy oil (3.06%, .98 kg/d) infusion.	Lecithins	63-71	Weaning weight-maternal milk	Bos taurus	0-4
3623702-7	1987	Adjacent, nonexposed bowel remained normal, as did loops injected with lecithin-neutralized toxin.	Lecithins	71-79	AT695_RS01930	Staphylococcus aureus	92-97
3660159-3	1987	Secretin infusion increased bile reflux into the stomach and promoted the production of lysolecithin from lecithin.	Lecithins	92-100	SCT	Canis lupus familiaris	0-8
2442186-8	1987	Significant negative correlations were found between the levels of both BP-28 and BP-53 and the lecithin to sphingomyelin ratio, suggesting an association between the levels of both proteins and the degree of fetal maturity.	Lecithins	96-104	BP53	Homo sapiens	82-87
3563818-2	1987	Secretin increased the amount of bile reflux and promoted the production of lysolecithin from lecithin.	Lecithins	80-88	SCT	Canis lupus familiaris	0-8
3630041-3	1987	Biological effects of lecithin could be explained by its role as a catalyst of the monooxygenase system in the liver, based on the correlation (r = +0.8) between the high level of cytochrome b5 and the degree of eximerization of the fluorescent probe pyrene in the microsomes.	Lecithins	22-30	cytochrome b5 type A	Rattus norvegicus	180-193
3802501-2	1987	Phospholipase C (EC 3.1.4.3) and sphingomyelin phosphodiesterase (EC 3.1.4.12) are reacted with lecithin and sphingomyelin, respectively, to liberate phosphocholine.	Lecithins	96-104	sphingomyelin phosphodiesterase 1	Homo sapiens	33-64
3548819-5	1987	With 1-fluoro-2,4-dinitrobenzene as the labeling reagent, the relative chemical reactivities of the functional groups of insulin were found to decrease markedly when insulin was incubated with liposomes consisting of egg lecithin and cholesterol (2:1 mol/mol) in 1.0 M KCl, pH 7.5 at 37 degrees C. The decrease for each functional group was found to directly correlate with its proximity to the dimer-forming surface of the monomer.	Lecithins	221-229	insulin	Homo sapiens	121-128
3548819-5	1987	With 1-fluoro-2,4-dinitrobenzene as the labeling reagent, the relative chemical reactivities of the functional groups of insulin were found to decrease markedly when insulin was incubated with liposomes consisting of egg lecithin and cholesterol (2:1 mol/mol) in 1.0 M KCl, pH 7.5 at 37 degrees C. The decrease for each functional group was found to directly correlate with its proximity to the dimer-forming surface of the monomer.	Lecithins	221-229	insulin	Homo sapiens	166-173
3037840-6	1987	However, rabbits inoculated with FCA, gangliosides, lecithin and cholesterol had rising titers of antibody to both MBP and GC over the 3-month experimental period.	Lecithins	52-60	myelin basic protein	Oryctolagus cuniculus	115-118
3026684-2	1987	In this study I show that: incorporation of ammonium sulfate into silica gel "GHL" has a dramatic effect on separation of lung phospholipids; this effect is equally dramatic but different in activated and nonactivated gels; when it picks up moisture, ammonium sulfate-activated gel very rapidly loses its ability to resolve lecithin from phosphatidylinositol; in gel containing ammonium sulfate, small amounts of phosphatidylethanolamine are hydrolyzed to lyso-phosphatidylethanolamine.	Lecithins	324-332	growth hormone 2	Homo sapiens	78-81
3956740-5	1986	From the steady-state distribution of PAF between inner and outer membrane layers, after very long incubation times (40-50 h), a preference of PAF for the outer membrane layer analogous to that of endogenous lecithin is derived.	Lecithins	208-216	PCNA clamp associated factor	Homo sapiens	143-146
3810007-4	1986	A 25% increase in mucin viscosity was obtained with 10 mM lecithin.	Lecithins	58-66	LOC100508689	Homo sapiens	18-23
3700425-2	1986	Human plasma lecithin-cholesterol acyltransferase (LCAT) transacylates the sn-2 fatty acid of lecithin to cholesterol forming cholesteryl ester and lysolecithin.	Lecithins	13-21	lecithin-cholesterol acyltransferase	Homo sapiens	51-55
3700425-7	1986	Lecithin alone protected the phospholipase A2 activity against phenylmethanesulfonyl fluoride inactivation but not the transacylase against 5,5"-dithiobis-(2-nitrobenzoic acid) inactivation.	Lecithins	0-8	phospholipase A2 group IB	Homo sapiens	29-45
3029530-0	1987	Effect of lecithin on the release of 5"-nucleotidase from liver plasma membrane of rat by bile acids.	Lecithins	10-18	5' nucleotidase, ecto	Rattus norvegicus	37-52
3947085-2	1986	The process of reactivation of BDH by phospholipids, which follows a second-order mechanism, reveals that (1) at least 2 mol of lecithins is essential for the reactivation of the enzyme, and (2) the enzyme contains two dependent binding sites for lecithins.	Lecithins	128-137	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	31-34
3697416-4	1986	Analysis of the adsorption capacity of natural and artificial phospholipid membranes showed that hexokinase isozyme II is adsorbed in much the same way on inner and outer mitochondrial membranes as well as on a mixture of membranes obtained from various sources and on lecithin liposomes.	Lecithins	269-277	hexokinase 1	Homo sapiens	97-107
3082628-9	1986	These results indicated that apo A-II must be incorporated together with apo A-I into lecithin-cholesterol liposomes to exert its stimulatory effect on LCAT activity and that apo A-II in high-density lipoprotein may play an important role in the regulation of LCAT activity.	Lecithins	86-94	apolipoprotein A2	Homo sapiens	29-37
3082628-9	1986	These results indicated that apo A-II must be incorporated together with apo A-I into lecithin-cholesterol liposomes to exert its stimulatory effect on LCAT activity and that apo A-II in high-density lipoprotein may play an important role in the regulation of LCAT activity.	Lecithins	86-94	apolipoprotein A1	Homo sapiens	29-36
3947085-2	1986	The process of reactivation of BDH by phospholipids, which follows a second-order mechanism, reveals that (1) at least 2 mol of lecithins is essential for the reactivation of the enzyme, and (2) the enzyme contains two dependent binding sites for lecithins.	Lecithins	247-256	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	31-34
3004216-1	1986	Concentrations of collagenase inhibitor in amniotic fluid correlated with gestational age and with indices of fetal lung maturity such as the lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol.	Lecithins	142-150	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-39
2995353-11	1985	These results demonstrate that when lecithin:cholesterol acyltransferase activity, cholesterol, and apo-E are present in serum, typical HDL can be transformed in vitro into large cholesterol-rich HDL1/HDLc that are capable of binding to lipoprotein receptors.	Lecithins	36-44	high density lipoprotein (HDL) level 1	Mus musculus	196-200
3775794-7	1986	These results do not agree with the accepted idea that bee venom phospholipase A2 hydrolyzes short-chain lecithins in their molecularly dispersed form and that micelles cannot act as substrates.	Lecithins	105-114	phospholipase A2 group IB	Homo sapiens	65-81
4053379-0	1985	Clinical experience with the Helena Fetal-Tek method of lecithin/sphingomyelin determination.	Lecithins	56-64	TEK receptor tyrosine kinase	Homo sapiens	42-45
4090378-1	1985	A procedure is described for production of artificial substrate, containing except of cholesterol and lecithin as well as the protein moiety, used in estimation of the rate of lecithin-cholesterol-acyltransferase reaction in whole blood plasma.	Lecithins	102-110	lecithin-cholesterol acyltransferase	Homo sapiens	176-212
3906680-1	1985	Microvesicles made of mixtures of lecithin and phosphatidic acid were precipitated by insulin in acid solution.	Lecithins	34-42	insulin	Homo sapiens	86-93
4056534-1	1985	In diabetic pregnancy, a high rate of postnatal development of RDS has been observed even with a mature lecithin/sphingomyelin (L/S) ratio, and the efficacy of phosphatidylglycerol (PG), a second major surfactant phospholipid, in predicting fetal lung maturity remains to be established.	Lecithins	104-112	peripherin 2	Homo sapiens	63-66
3918999-5	1985	Apo-A-I was a more potent activator than apo-A-IV with egg yolk lecithin, L-alpha-dioleoylphosphatidylcholine, and L-alpha-phosphatidylcholine substituted with one saturated and one unsaturated fatty acid regardless of the substitution position.	Lecithins	64-72	apolipoprotein A1	Homo sapiens	0-7
4088228-3	1985	Successively, lysolecithin and free fatty acids are produced by hydrolysis of lecithin in bile with phospholipase A2.	Lecithins	18-26	phospholipase A2 group IB	Homo sapiens	100-116
3905074-4	1985	Lecithin hydrolysis by phospholipase A2 was dependent on the bile salt/lecithin molar ratio and was optimal at 1.25 to 1.	Lecithins	71-79	phospholipase A2 group IB	Homo sapiens	23-39
3918999-5	1985	Apo-A-I was a more potent activator than apo-A-IV with egg yolk lecithin, L-alpha-dioleoylphosphatidylcholine, and L-alpha-phosphatidylcholine substituted with one saturated and one unsaturated fatty acid regardless of the substitution position.	Lecithins	64-72	apolipoprotein A4	Homo sapiens	41-49
6508788-4	1984	The potential role of SM PLD liberating choline from lecithin into the synaptic cleft is discussed in relationship to acetylcholine formation.	Lecithins	53-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
6520125-3	1984	A single protein peak of the eluate from the latter column was found to inhibit PLA2 activity in a dose-dependent manner in an assay system using radioactive lecithin as a substrate and porcine pancreatic PLA2 as the enzyme source.	Lecithins	158-166	phospholipase A2 group IB	Homo sapiens	80-84
6496677-7	1984	In contrast to purified human pancreatic lipase, lingual lipase hydrolyzed triglyceride emulsions and mixed micelles stabilized with both short-chain (dihexanoyl) and long-chain (egg) lecithin and were inhibited only slightly (18-25%) by micellar concentrations of two common bile salts, taurodeoxycholate and taurocholate.	Lecithins	184-192	lipase F, gastric type	Rattus norvegicus	49-63
6564129-0	1984	High density lipoproteins and lecithin dispersions increase the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by increasing the rate of synthesis and decreasing the rate of degradation of the enzyme.	Lecithins	30-38	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	76-123
6423754-6	1984	The isoprotein-2 of normal apoA-I and the isoprotein-4 of Tangier apoA-I generate lipid-rich complexes with lecithin, while the isoprotein-2 of Tangier apoA-I shows only a limited association with lipids.	Lecithins	108-116	apolipoprotein A1	Homo sapiens	27-33
6202688-7	1984	When apo-B was equilibrated with either SDS micelles or with cholesterol-lecithin liposomes, the immunoreactivity of the determinant recognized by antibody 2D8 was partially regenerated, but not that of the others.	Lecithins	73-81	apolipoprotein B	Homo sapiens	5-10
6331532-1	1984	Lecithin monolayer liposomes (1000 A in diameter) loaded with cytochrome c were placed into the external solution, in which O2 superoxide radicals were regenerated by the xanthine-xanthine oxidase system.	Lecithins	0-8	cytochrome c, somatic	Homo sapiens	62-74
6728567-3	1984	The data presented show that partially purified preparations of rat lingual lipase and the lipase in gastric aspirates of newborn infants have identical substrate specificity: medium-chain triglycerides were hydrolyzed at rates 5-8-fold higher than long-chain triglycerides; the rat and human enzymes do not hydrolyze the ester bond of lecithin or cholesteryl-ester.	Lecithins	336-344	lipase F, gastric type	Rattus norvegicus	68-82
6728567-3	1984	The data presented show that partially purified preparations of rat lingual lipase and the lipase in gastric aspirates of newborn infants have identical substrate specificity: medium-chain triglycerides were hydrolyzed at rates 5-8-fold higher than long-chain triglycerides; the rat and human enzymes do not hydrolyze the ester bond of lecithin or cholesteryl-ester.	Lecithins	336-344	lipase G, endothelial type	Rattus norvegicus	76-82
6733130-6	1984	However, kinetic studies of the hydrolysis of a lecithin-stabilized emulsion of triacylglycerol (Intralipid) by chicken lipase show that the lag period is much longer in the presence of porcine colipase than with the chicken cofactor.	Lecithins	48-56	colipase	Gallus gallus	194-202
6708755-1	1984	Lecithin-cholesterol acyltransferase (LCAT) in human plasma has been shown to acylate lysolecithin to lecithin in presence of low density lipoprotein (LDL).	Lecithins	90-98	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
6423754-6	1984	The isoprotein-2 of normal apoA-I and the isoprotein-4 of Tangier apoA-I generate lipid-rich complexes with lecithin, while the isoprotein-2 of Tangier apoA-I shows only a limited association with lipids.	Lecithins	108-116	apolipoprotein A1	Homo sapiens	66-72
6708755-1	1984	Lecithin-cholesterol acyltransferase (LCAT) in human plasma has been shown to acylate lysolecithin to lecithin in presence of low density lipoprotein (LDL).	Lecithins	90-98	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
6423754-6	1984	The isoprotein-2 of normal apoA-I and the isoprotein-4 of Tangier apoA-I generate lipid-rich complexes with lecithin, while the isoprotein-2 of Tangier apoA-I shows only a limited association with lipids.	Lecithins	108-116	apolipoprotein A1	Homo sapiens	66-72
6423754-9	1984	This transition was observed for the isoprotein-2 of apoA-I Tangier both in its lipid-free form and in the presence of lecithin.	Lecithins	119-127	apolipoprotein A1	Homo sapiens	53-59
6870893-2	1983	In contrast to porcine pancreatic phospholipase A2, the LpL-catalyzed hydrolysis of these short-chain lecithins was not enhanced at substrate concentrations above the critical micelle concentration of the lipids.	Lecithins	102-111	lipoprotein lipase	Bos taurus	56-59
6318838-1	1983	Purified preparations of Ca2+-dependent ATPase were lipid-deleted and incorporated into egg lecithin (EL) and dipalmitoyl lecithin (DPL) liposomes.	Lecithins	92-100	dynein axonemal heavy chain 8	Homo sapiens	40-46
6628667-6	1983	It determines whether colipase assists lipase in binding to the bile salt-covered triglyceride droplet as is the case with tributyrin as substrate, and whether colipase in addition activates lipase as is the case with a mixed trioctanoin/lecithin monolayer substrate.	Lecithins	238-246	colipase	Homo sapiens	22-30
6411369-3	1983	On the other hand, microsomal lipids from rat liver and commercial pig liver lecithin diminished the amount of N-hydroxy-Trp-P-2 without inhibiting the metabolism of Trp-P-2.	Lecithins	77-85	polycystin 2, transient receptor potential cation channel	Sus scrofa	121-128
6411369-3	1983	On the other hand, microsomal lipids from rat liver and commercial pig liver lecithin diminished the amount of N-hydroxy-Trp-P-2 without inhibiting the metabolism of Trp-P-2.	Lecithins	77-85	polycystin 2, transient receptor potential cation channel	Sus scrofa	166-173
6860421-6	1983	When incorporated with egg lecithin into discoidal complexes, the apolipoprotein E from affected members was taken up normally into perfused livers of estradiol-treated rats, in which a high level of LDL receptors is expressed.	Lecithins	27-35	apolipoprotein E	Rattus norvegicus	66-82
6684478-1	1983	Binary and ternary complexes of apolipoprotein B (apo B) with egg yolk lecithin and with lecithin plus cholesterol have been formed from detergent-lipid-protein mixed micelles.	Lecithins	71-79	apolipoprotein B	Homo sapiens	32-48
6684478-1	1983	Binary and ternary complexes of apolipoprotein B (apo B) with egg yolk lecithin and with lecithin plus cholesterol have been formed from detergent-lipid-protein mixed micelles.	Lecithins	71-79	apolipoprotein B	Homo sapiens	50-55
7116686-0	1982	H-2b bound to egg lecithin liposomes: biochemical and functional properties.	Lecithins	18-26	H2B clustered histone 21	Homo sapiens	0-4
6838196-0	1983	Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile salt mixed micelles: kinetic studies in a lecithin-sodium cholate system.	Lecithins	83-91	phospholipase A2 group IB	Homo sapiens	19-35
6838196-1	1983	Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in bile salt lecithin mixed micelles has been studied, utilizing a series of assay mixtures for which the micellar size, weight, and composition had been experimentally determined.	Lecithins	93-101	phospholipase A2 group IB	Homo sapiens	19-35
6838202-1	1983	Human skeletal alkaline phosphatase (ALP) purified from human bone was subject to competitive inhibitions by phospholipids including cephalins, lecithins, and phosphatidylinositol.	Lecithins	144-153	alkaline phosphatase, placental	Homo sapiens	15-35
6838202-1	1983	Human skeletal alkaline phosphatase (ALP) purified from human bone was subject to competitive inhibitions by phospholipids including cephalins, lecithins, and phosphatidylinositol.	Lecithins	144-153	alkaline phosphatase, placental	Homo sapiens	37-40
6856989-6	1983	It was concluded that phospholipase A2, released from pancreatic acinar cells into blood, may convert pulmonary lecithin into lysolecithin during acute pancreatitis.	Lecithins	112-120	phospholipase A2 group IB	Rattus norvegicus	22-38
7172508-5	1982	However in vitro addition of known ligands for CRP to acute phase serum resulted in lowering of the apparent CRP concentration in this assay and addition of as little as 1 microgram/l of free CPS or 1 mg/l of lecithin was demonstrable in this way.	Lecithins	209-217	C-reactive protein	Homo sapiens	47-50
7138813-0	1982	Reactivation of D-beta-hydroxybutyrate dehydrogenase with short-chain lecithins: stoichiometry and kinetic mechanism.	Lecithins	70-79	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	16-52
7138813-1	1982	D-beta-Hydroxybutyrate dehydrogenase (BDH), purified as soluble, lipid-free apoenzyme (inactive) from either beef heart or rat liver mitochondria, can be reactivated by short-chain lecithins in the monomeric state.	Lecithins	181-190	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	0-36
7138813-1	1982	D-beta-Hydroxybutyrate dehydrogenase (BDH), purified as soluble, lipid-free apoenzyme (inactive) from either beef heart or rat liver mitochondria, can be reactivated by short-chain lecithins in the monomeric state.	Lecithins	181-190	3-hydroxybutyrate dehydrogenase 1	Rattus norvegicus	38-41
6433926-2	1983	By addition of L-alpha-lecithin to the pleural effusion in the presence of calcium ions, a flocculence of the CRP-lecithin complex formed.	Lecithins	23-31	C-reactive protein	Homo sapiens	110-113
7159494-2	1982	Because lecithin-cholesterol acyltransferase (LCAT) has been shown to carry out acylation of lysolecithin as well as hydrolysis of lecithin in addition to an esterification of cholesterol, the cofactor requirements of the three reactions catalyzed by the enzyme were studied.	Lecithins	8-16	lecithin-cholesterol acyltransferase	Homo sapiens	46-50
6796127-2	1981	The amino acid composition is given for a C-reactive protein isolated from the eggs of a marine teleost, Cyclopterus lumpus, by extraction with lecithin in the presence of Ca2+, followed by electrofocusing.	Lecithins	144-152	C-reactive protein	Homo sapiens	42-60
7078415-1	1982	Previous studies from this laboratory have shown that the lecithin:cholesterol acyl transferase (LCAT) of normal human plasma can convert lysolecithin to lecithin in the presence of low density lipoproteins (LDL).	Lecithins	58-66	lecithin-cholesterol acyltransferase	Homo sapiens	97-101
7102338-0	1982	[Effects of lecithin quality on encapsulation ratio of MTX-liposome (author"s transl)].	Lecithins	12-20	metaxin 1	Homo sapiens	55-58
6461976-8	1982	Extensive restoration of the Ca2+-dependent ATPase activity has been achieved by oleic acid, a lysolecithin (myristoylglycerophosphocholine) and a lecithin (dimyristoylglycerophosphocholine).	Lecithins	99-107	dynein axonemal heavy chain 8	Homo sapiens	44-50
7035304-3	1982	LYN did not alter the IVGTT or plasma insulin but decreased the proportion of polyunsaturated fatty acids (PUFA) in serum lecithin (p less than 0.01) and cholesterol esters (p less than 0.01) where oleic acid was reciprocally increased (p less than 0.05).	Lecithins	122-130	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
7035304-7	1982	EE + LYN also increased (p less than 0.05) lecithin palmitate and decreased stearate (p less than 0.05) and had a concomitant tendency to lower PUFA and increase oleic acid in both lecithin and cholesterol esters.	Lecithins	43-51	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
7240416-12	1981	Purified human gallbladder mucin gels were shown to induce nucleation of lecithin-cholesterol liquid crystals from supersaturated hepatic bile.	Lecithins	73-81	LOC100508689	Homo sapiens	27-32
6792197-1	1981	The free energy of association of lecithin with reduced and carboxymethylated apolipoprotein A-II from human plasma high density lipoprotein.	Lecithins	34-42	apolipoprotein A2	Homo sapiens	78-97
7316183-0	1981	Continuous fluorometric assay of phospholipase A2 with pyrene-labeled lecithin as a substrate.	Lecithins	70-78	phospholipase A2 group IB	Homo sapiens	33-49
7241575-2	1981	Cleavage of 55% of the lecithin in intact human erythrocytes by phospholipase A2 (bee venom) markedly inhibits the mediated transport of L-lactate (via the monocarboxylate carrier) and of L-arabinose (via the monosaccharide carrier), while the major anion exchange system (probed by oxalate) and diffusion via the lipid domain (probed by erythritol) remain essentially unaltered.	Lecithins	23-31	phospholipase A2 group IB	Homo sapiens	64-80
7204386-11	1981	Adsorption of cholesterol esterase to lecithin monolayers is less than one-tenth that to oleic acid monolayers and is proportional to subphase enzyme concentration.	Lecithins	38-46	carboxyl ester lipase	Homo sapiens	14-34
7236803-2	1981	The necessity of phospholipase A2 for Ca2+ depends on the type of substrates (phosphatidyl methanol, phosphatidyl ethanol, cephalin, phosphatidyl ethyleneglycol, phosphatidyl inositol), whereas enzymatic cleavage of lecithin can also occur in the absence of Ca2+.	Lecithins	216-224	phospholipase A2 group IB	Homo sapiens	17-33
471064-3	1979	CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM).	Lecithins	123-131	C-reactive protein	Homo sapiens	0-3
6801887-5	1981	These results suggest that apo A-II has a higher affinity than apo A-I for the lecithin-cholesterol vesicle and that 2 mol apo A-II are able to displace 1 mol apo A-I from the apo A-I lipid complexes.	Lecithins	79-87	apolipoprotein A2	Homo sapiens	27-35
6801887-5	1981	These results suggest that apo A-II has a higher affinity than apo A-I for the lecithin-cholesterol vesicle and that 2 mol apo A-II are able to displace 1 mol apo A-I from the apo A-I lipid complexes.	Lecithins	79-87	apolipoprotein A1	Homo sapiens	27-34
6801887-5	1981	These results suggest that apo A-II has a higher affinity than apo A-I for the lecithin-cholesterol vesicle and that 2 mol apo A-II are able to displace 1 mol apo A-I from the apo A-I lipid complexes.	Lecithins	79-87	apolipoprotein A2	Homo sapiens	123-131
6801887-5	1981	These results suggest that apo A-II has a higher affinity than apo A-I for the lecithin-cholesterol vesicle and that 2 mol apo A-II are able to displace 1 mol apo A-I from the apo A-I lipid complexes.	Lecithins	79-87	apolipoprotein A1	Homo sapiens	63-70
6801887-5	1981	These results suggest that apo A-II has a higher affinity than apo A-I for the lecithin-cholesterol vesicle and that 2 mol apo A-II are able to displace 1 mol apo A-I from the apo A-I lipid complexes.	Lecithins	79-87	apolipoprotein A1	Homo sapiens	63-70
6894279-3	1981	The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme.	Lecithins	15-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-100
6894279-3	1981	The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme.	Lecithins	189-197	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-100
6894279-4	1981	Binding to lecithin decrease the optimum pH value for acetylcholinesterase, increase the resistance of the enzyme to heat denaturation and reduces the extent of activation by Ca2+.	Lecithins	11-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-74
7255875-0	1981	Decreased retention of fatty acid conjugated DDT metabolites in rats given injections of heparin, bile salts or lecithin.	Lecithins	112-120	D-dopachrome tautomerase	Rattus norvegicus	45-48
7255875-1	1981	Intravenous injections of solutions of heparin, bile salts or lecithin into rats previously intraperitoneally injected with 14C-DDT significantly removed fatty acid conjugated 14C-DDT metabolites retained in their livers and spleens.	Lecithins	62-70	D-dopachrome tautomerase	Rattus norvegicus	128-131
7255875-1	1981	Intravenous injections of solutions of heparin, bile salts or lecithin into rats previously intraperitoneally injected with 14C-DDT significantly removed fatty acid conjugated 14C-DDT metabolites retained in their livers and spleens.	Lecithins	62-70	D-dopachrome tautomerase	Rattus norvegicus	180-183
7428120-5	1980	The low affinity of BP-9,10-dihydrodiol for lecithin would account for earlier findings that on incubation of BP with isolated rat hepatocytes, this metabolite egressed from the cells to the extracellular medium much more readily than either BP-4,5-dihydrodiol or BP-7,8-dihydrodiol.	Lecithins	44-52	Blood pressure QTL 9	Rattus norvegicus	20-24
6165066-7	1980	It was concluded that phospholipase A, which converts lecithin into lysolecithin, plays a significant role in the pathogenesis of acute pancreatitis.	Lecithins	54-62	phospholipase A and acyltransferase 1	Rattus norvegicus	22-37
489586-0	1979	Hydrolysis of mixed monomolecular films of triglyceride/lecithin by pancreatic lipase.	Lecithins	56-64	pancreatic lipase	Homo sapiens	68-85
489586-1	1979	The main purpose of this study was to describe the influence of lecithin upon lipolysis of mixed monomolecular films of trioctanoylglycerol/didodecanoylphosphatidycholine by pancreatic lipase in order to mimic some physiological situations.	Lecithins	64-72	pancreatic lipase	Homo sapiens	174-191
6167292-2	1981	For Gra A beta depends on the concentration of electrolyte c increasing lg c from -17 B-2 at 0.03 M to 8 B-2 at 3.4 M KCl turning to 0 at c0 = 0.3 divided by 1 M. The membranes of egg lecithin and glycerylmonooleate (GMO) differ in c0 value.	Lecithins	184-192	amyloid beta precursor protein	Homo sapiens	8-14
7236798-1	1980	This secondary structure of soluble cytochrome P-450 and the one incorporated into liposomes from egg lecithin and microsomal lipids has been studied.	Lecithins	102-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-52
7236798-6	1980	Data from circular dichroism suggest that the binding of the types I and II substrates to cytochrome P-450 incorporated into lecithin liposomes and microsomal lipid liposomes does not change the conformation of the polypeptide chain.	Lecithins	125-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-106
6991910-0	1980	Insulin-lecithin interaction in non-aqueous solvents and its change after application of a static electric field.	Lecithins	8-16	insulin	Homo sapiens	0-7
6991910-3	1980	The different strength of interaction of insulin with the two types of lecithins results also from experiments with a two-phase system.	Lecithins	71-80	insulin	Homo sapiens	41-48
570415-4	1979	The most probable order parameter for the (-CD2)n portion of the homogeneous fraction of cholesteryl palmitate-d31 was determined from the quadrupolar splittings to be S = 0.1 which is less than one-half that of the order parameter found for the lecithin chains.	Lecithins	246-254	CD2 molecule	Homo sapiens	44-47
581927-8	1979	These results indicate that qualitative changes in amniotic fluid lecithin composition are a part of the fetal response to glucocorticoids which may be responsible for the decreased incidence of RDS observed after treatment.	Lecithins	66-74	peripherin 2	Homo sapiens	195-198
573135-1	1979	Interfacial regulation of phospholipase A2 activity on lecithin monolayers was investigated by using radioactively labeled enzyme.	Lecithins	55-63	phospholipase A2 group IB	Homo sapiens	26-42
573135-8	1979	However, the steady-state surface concentration of the enzyme increases with the fatty acyl chain length of the lecithin, indicating that hydrophobic interaction occurs between phospholipase A2 and the lipid molecules at the interface.	Lecithins	112-120	phospholipase A2 group IB	Homo sapiens	177-193
573136-4	1979	At pH 6 [Gly1]phospholipase A2 behaves like the native enzyme on lecithin monolayers.	Lecithins	65-73	phospholipase A2 group IB	Homo sapiens	14-30
218072-6	1979	Both activities were reconstituted in the presence of deoxycholate on addition of the other components of the cytochrome b5-electron transport chain (cytochrome b5 and NADH-cytochrome b5 reductase) to the solubilized desaturase; addition of lecithin further stimulated the activities.	Lecithins	241-249	cytochrome b5 type A	Rattus norvegicus	110-123
221605-5	1979	HDL(2) lipids and protein increased substantially, characterized primarily by enrichment with lecithin.	Lecithins	94-102	junctophilin 3	Homo sapiens	0-5
575476-6	1979	The effect of purified human plasma apolipoproteins A-I, A-II, C-I, C-II, C-III and D on the activity of purified LCAT was studied, using egg-yolk lecithin (40 microM): cholesterol (10 microM) vesicles prepared in 1.25% ethanol in the absence or presence of 0.5% albumin.	Lecithins	147-155	lecithin-cholesterol acyltransferase	Homo sapiens	114-118
32413-0	1978	Antimycobacterial activity of lecithin-cholesterol liposomes in the presence of phospholipase A2.	Lecithins	30-38	phospholipase A2 group IB	Homo sapiens	80-96
733058-4	1978	These findings may be the result of a low lecithin: cholesterol-acyltransferase (LCAT) activity, due either to depression of the enzyme syntesis in the liver, or to inadequate substrate supply (possibly related with an impaired fatty acid production and lecithin synthesis).	Lecithins	42-50	lecithin-cholesterol acyltransferase	Homo sapiens	81-85
698251-9	1978	The qualitative studies of the influence of the solution composition and temperature showed that in the range 25--40 degrees C in different solutions the excitation effects of BLM from general lipids of brain and a lecithin-cholesterol mixture are qualitatively similar and resemble those due to some biologically active substances diminishing the mechanical stability of BLM.	Lecithins	215-223	BLM RecQ like helicase	Homo sapiens	176-179
911718-0	1977	The effect of intrauterine fetal transfusion and a beta-sympathomimetic substance on the lecithin/sphingomyelin ratio in human amniotic fluid.	Lecithins	89-97	amyloid beta precursor protein	Homo sapiens	49-55
957026-0	1976	Letter: Effect of cortisol/insulin in lecithin synthesis.	Lecithins	38-46	insulin	Homo sapiens	27-34
577607-3	1977	These results tend to support the hypothesis that insulin can inhibit lecithin synthesis.	Lecithins	70-78	insulin	Homo sapiens	50-57
874076-12	1977	Variations in the sphingomyelin/lecithin mole ratio of liposomes prepared from brain sphingomyelin and egg lecithin with equimolar cholesterol caused similar changes in both eta and activation energy.	Lecithins	32-40	endothelin receptor type A	Homo sapiens	174-177
874076-12	1977	Variations in the sphingomyelin/lecithin mole ratio of liposomes prepared from brain sphingomyelin and egg lecithin with equimolar cholesterol caused similar changes in both eta and activation energy.	Lecithins	107-115	endothelin receptor type A	Homo sapiens	174-177
197061-4	1977	The lecithin:cholesterol  acyltransferase (LCAT) reaction could be completely inhibited during preparation, and the net recovery of radioactivity in LDL was 16% of that of the original lecithin dispersion.	Lecithins	4-12	lecithin-cholesterol acyltransferase	Homo sapiens	43-47
193772-1	1977	Intermolecular cross-linkage between high-density apolipoprotein A-I and lecithins and sphingomyelins.	Lecithins	73-82	apolipoprotein A1	Homo sapiens	50-68
191161-2	1977	Temperature-induced changes of these liposomes, detected by the spin-labelled phospholipids, were found to be in agreement with the previously described transitions of hydrocarbon chains of host lecithins detected by different probes and different techniques, establishing that spin-labelled phosopholipids are sensitive probes for the detection of temperature-induced changes in lecithin model membranes.	Lecithins	195-203	spindlin 1	Homo sapiens	64-68
11817-1	1976	The mitochondrial ferrochelatase activity has been studied in coupled rat liver mitochondria using deuteroporphyrin IX (incorporated into liposomes of lecithin) and Fe(III) or Co(II) as the substrates.	Lecithins	151-159	ferrochelatase	Rattus norvegicus	18-32
991389-2	1976	The utility of the mixed carboxylic-sulfonic acid anhydride stearoyl p-toluenesulfonate as a powerful, mild acylating agent for lipid synthesis is shown by the synthesis of rac 1,2-distearoyl-3-iodopropane, lecithin and a spin-labeled choline derivative from the corresponding alcohols.	Lecithins	207-215	Rac family small GTPase 1	Homo sapiens	173-178
1010843-1	1976	The effects of cholesterol sulfate and sodium dodecyl sulfate (SDS) on the esterification of cholesterol in sonicated dispersions of lecithin-cholesterol mixtures by lecithin-cholesterol acyltransferase [EC 2.3.1.43] (LCAT) in human plasma were studied in vitro.	Lecithins	133-141	lecithin-cholesterol acyltransferase	Homo sapiens	166-202
576871-0	1977	The effect of prolactin on the lecithin content of fetal rabbit lung.	Lecithins	31-39	prolactin	Oryctolagus cuniculus	14-23
576871-4	1977	Analysis of lung tissue composition yielded the following results: (a) the prolactin-treated group of fetuses showed 40% higher total lung phospholipid content (17.0 +/- 0.8 micronmol/g) than the control group (12.2 +/- 0.5 micronmol/g); (b) the prolactin-treated group had a 67% higher lung lecithin content (8.7 +/- 0.8 micronmol/g) than the control group (5.2 +/- 0.4 micronmol/g); (c) dipalmitoyllecithin accounted for 67% of total lung lecithin in the prolactin-treated group and 44% in the control group.	Lecithins	292-300	prolactin	Oryctolagus cuniculus	75-84
191161-0	1977	Temperature-induced changes in lecithin model membranes detected by novel covalent spin-labelled phospholipids.	Lecithins	31-39	spindlin 1	Homo sapiens	83-87
188642-1	1976	The interaction of synthetic dimyristoyl phosphatidylcholine (lecithin) liposomes with isolated apoC-I and apoC-III proteins from very low density lipoproteins has been studied by microcalorimetry.	Lecithins	62-70	apolipoprotein C1	Homo sapiens	96-102
188642-1	1976	The interaction of synthetic dimyristoyl phosphatidylcholine (lecithin) liposomes with isolated apoC-I and apoC-III proteins from very low density lipoproteins has been studied by microcalorimetry.	Lecithins	62-70	apolipoprotein C3	Homo sapiens	107-115
133195-0	1976	Local anesthetic inhibition of pancreatic phospholipase A2 action on lecithin monolayers.	Lecithins	69-77	phospholipase A2 group IB	Homo sapiens	42-58
986397-3	1976	The ability of lipid vesicles of simple composition (lecithin, lysolecithin, and stearylamine) to induce cells of various types to fuse has been investigated.	Lecithins	53-61	Polykaryocytosis inducer	Homo sapiens	131-135
983654-11	1976	The results are interpreted such that phospholipase A activity from the gallbladder epithelium, if released into the gallbladder bile, may generate lysolecithin from lecithin.	Lecithins	152-160	phospholipase A and acyltransferase 1	Homo sapiens	38-53
1015152-2	1976	It was found that lecithin and the detergents used (deoxycholate and sodium dodecylate) inhibited the renin activity.	Lecithins	18-26	renin	Bos taurus	102-107
241422-0	1975	Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase of isolated rat hepatocytes.	Lecithins	34-42	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	86-133
1185403-2	1975	The addition of insulin (25-100 muU/ml) abolishes the stimulatory effect of cortisol on lecithin synthesis but does not affect its growth-inhibiting activity.	Lecithins	88-96	insulin	Oryctolagus cuniculus	16-23
198365-4	1975	Silicogenic dusts activate a phospholipase A in macrophages leading to a concentration and time-dependent degradation of lecithin and cephalin.	Lecithins	121-129	phospholipase A and acyltransferase 1	Mus musculus	29-44
170277-12	1975	HDLs were also made by incubating dispersed lecithin or lecithin + cholesterol with Apo-HDL, ApoA-I, or ApoA-II.	Lecithins	44-52	apolipoprotein A1	Homo sapiens	93-99
170277-12	1975	HDLs were also made by incubating dispersed lecithin or lecithin + cholesterol with Apo-HDL, ApoA-I, or ApoA-II.	Lecithins	44-52	apolipoprotein A2	Homo sapiens	104-111
170277-12	1975	HDLs were also made by incubating dispersed lecithin or lecithin + cholesterol with Apo-HDL, ApoA-I, or ApoA-II.	Lecithins	56-64	apolipoprotein A2	Homo sapiens	104-111
127477-4	1975	After incubation with phospholipase-A2 the lecithin and cephalin streaks were reduced and in addition lysophosphatide and fatty acid streaks were detected.	Lecithins	43-51	phospholipase A2 group IB	Homo sapiens	22-38
1097530-3	1975	When GM1 ganglioside, in the form of cholesterol-lecithin liposomes, was incubated with spleen cell cultures in the presence of SRBC, depressed anti-SRBC hemolytic plaque responses were observed.	Lecithins	49-57	coenzyme Q10A	Mus musculus	5-8
1086224-13	1975	These findings strongly suggest that the inhibition observed is due to residual phospholipase A reacting with lecithin in the mouse serum rather than to any anticomplementary effect.	Lecithins	110-118	phospholipase A and acyltransferase 1	Mus musculus	80-95
167919-2	1975	Incorporation of CDP[14C]choline into lecithin in rat liver or BHK-21 mitochondria could be attributed to residual contamination from elements of the endoplasmic reticulum, with added diglycerides or with endogenous diglycerides produced by the phospholipase C treatment.	Lecithins	38-46	cut-like homeobox 1	Rattus norvegicus	17-20
164944-8	1975	In lecithin liposomes maximal quenching of perylene fluorescence at 25 degrees C is effected by cholestane spin label (80%) followed by androstane spin label (70%), 5-nitroxide stearate (60%) and 16-nitroxide stearate (50%).	Lecithins	3-11	spindlin 1	Homo sapiens	107-111
164944-8	1975	In lecithin liposomes maximal quenching of perylene fluorescence at 25 degrees C is effected by cholestane spin label (80%) followed by androstane spin label (70%), 5-nitroxide stearate (60%) and 16-nitroxide stearate (50%).	Lecithins	3-11	spindlin 1	Homo sapiens	147-151
806301-3	1975	UDPglucuronosyltransferase was reactivated by dialysing this delipidated preparation in the presence of lecithin, a mixture of liver microsomal lipids or microsomal preparations from livers of UDPglucuronosyltransferase-deficient Gunn rats.	Lecithins	104-112	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-26
1148030-2	1975	The immediate and maximal conversion of plasma lecithin to lysolecithin was produced in rats by intravenous injection of phospholipase A.	Lecithins	47-55	phospholipase A and acyltransferase 1	Rattus norvegicus	121-136
1148030-5	1975	The experiments showed that a substantial part of the plasma lecithin was converted to lysolecithin within the first minute after intravenous administration of phospholipase A.	Lecithins	61-69	phospholipase A and acyltransferase 1	Rattus norvegicus	160-175
1148030-8	1975	In vivo, the converted lysolecithin was quickly released from the plasma, so that within 10 min the original lecithin content dropped to 15-5% depending on the dose of phospholipase A that had been administered.	Lecithins	27-35	phospholipase A and acyltransferase 1	Rattus norvegicus	168-183
165012-0	1975	An ESR Spin label study of structural and dynamical properties of oriented lecithin-cholesterol multibilayers.	Lecithins	75-83	spindlin 1	Homo sapiens	7-11
1173022-7	1975	The equation, log y equals minus 1.0187 minus 0.0101 chi, expresses the relationship in a highly significant manner (r equals 0.99) where y equals lecithin concentration and chi equals risk of RDS.	Lecithins	147-155	peripherin 2	Homo sapiens	193-196
4683885-4	1973	Thrombin caused marked depression of the incorporation of palmitic acid into both lecithin and triglycerides.	Lecithins	82-90	coagulation factor II, thrombin	Homo sapiens	0-8
164553-4	1975	In the present study, a typical extrinsic protein, cytochrome c, was complexed with a cardiolipin/lecithin (1:4 by weight) mixture.	Lecithins	98-106	cytochrome c, somatic	Homo sapiens	51-63
4151108-2	1974	Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.	Lecithins	153-161	C-reactive protein	Homo sapiens	64-82
4857663-0	1974	The influence of the alkyl chain length of lecithins and lysolecithins on their interaction with alphas1-casein.	Lecithins	43-52	casein alpha s1	Homo sapiens	97-111
4331782-0	1971	Silica gel stimulates the hydrolysis of lecithin by phospholipase A.	Lecithins	40-48	phospholipase A and acyltransferase 1	Homo sapiens	52-67
5076665-0	1972	Is the liver cytochrome P-450-linked biotransformation system lecithin-dependent?	Lecithins	62-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	13-29
5063604-0	1972	Chemical synthesis of some lecithin analogues potential inhibitors of phospholipase A.	Lecithins	27-35	phospholipase A and acyltransferase 1	Homo sapiens	70-85
5167549-0	1971	Kinetic analysis of the hydrolysis of lecithin monolayers by phospholipase A.	Lecithins	38-46	phospholipase A and acyltransferase 1	Homo sapiens	61-76
5000278-0	1971	Action of lecithin-cholesterol acyltransferase on sonicated dispersions of lecithin and cholesterol and on lecithin-cholesterol-protein complexes.	Lecithins	75-83	lecithin-cholesterol acyltransferase	Homo sapiens	10-46
4939182-0	1971	Significance of surface potential measurements on lipid monolayers during action of phospholipase A on lecithins.	Lecithins	103-112	phospholipase A and acyltransferase 1	Homo sapiens	84-99
4311934-0	1970	Spin-label study of the iodine-lecithin interaction.	Lecithins	31-39	spindlin 1	Homo sapiens	0-4
5546578-0	1971	Use of sonicated dispersions of mixtures of cholesterol with lecithin as substrates for lecithin:cholesterol acyltransferase.	Lecithins	61-69	lecithin-cholesterol acyltransferase	Homo sapiens	88-124
5484667-14	1970	By using (beta[1-(14)C]-oleoyl) lecithin it was shown that the mucosal phospholipase A was specific for the beta-ester linkage of the lecithin molecule.	Lecithins	32-40	phospholipase A and acyltransferase 1	Rattus norvegicus	71-86
5410453-0	1970	Effect of phospholipase A on cholesterol solubilization by lecithin in a bile salt solution.	Lecithins	59-67	phospholipase A and acyltransferase 1	Homo sapiens	10-25
4187623-4	1969	This esterification was accomplished by the transfer of fatty acids from the C-2 position of lecithin (phosphatidylcholine) to cholesterol.	Lecithins	93-101	complement C2	Oryctolagus cuniculus	77-80
6039841-0	1967	The effect of lecithin on the activity of pancreatic lipase.	Lecithins	14-22	pancreatic lipase	Homo sapiens	42-59
4386042-2	1968	Reacylation of lysolecithin following deacylation of lecithin by phospholipase A in aqueous medium].	Lecithins	19-27	phospholipase A and acyltransferase 1	Homo sapiens	65-80
4248813-0	1969	[Effect of lecithin sol on myosin activity in a myosin-lecithin system].	Lecithins	11-19	myosin heavy chain 14	Homo sapiens	27-33
4248813-0	1969	[Effect of lecithin sol on myosin activity in a myosin-lecithin system].	Lecithins	11-19	myosin heavy chain 14	Homo sapiens	48-54
6049674-2	1967	The results summarized below favor the view (a) that exchange of saturated fatty acids plays a role in the formation of lecithins; (b) that the unsaturated fatty acids do not undergo significant exchange and determine the pathway of biosynthesis of lecithins; and (c) that there is either more than one pool of CDP-choline in liver or a pathway of biosynthesis of lecithin from choline not involving CDP-choline as an intermediate.	Lecithins	249-258	cut-like homeobox 1	Rattus norvegicus	311-314
6049674-2	1967	The results summarized below favor the view (a) that exchange of saturated fatty acids plays a role in the formation of lecithins; (b) that the unsaturated fatty acids do not undergo significant exchange and determine the pathway of biosynthesis of lecithins; and (c) that there is either more than one pool of CDP-choline in liver or a pathway of biosynthesis of lecithin from choline not involving CDP-choline as an intermediate.	Lecithins	249-258	cut-like homeobox 1	Rattus norvegicus	400-403
13753593-0	1960	[Inhibition of 5-nucleotidase activity by the decomposition products of brain homogenates and lecithin digested with snake venom].	Lecithins	94-102	5'-nucleotidase ecto	Homo sapiens	15-29
14102757-0	1963	THE ENZYMIC HYDROLYSIS OF ULTRASONICALLY IRRADIATED LECITHIN BY PHOSPHOLIPASE A.	Lecithins	52-60	phospholipase A and acyltransferase 1	Homo sapiens	64-79
5891201-0	1965	Synthetic lecithins containing one short-chain fatty acid and their breakdown by phospholipase A.	Lecithins	10-19	phospholipase A and acyltransferase 1	Homo sapiens	81-96
14085944-0	1963	CONVERSION OF LIPOPROTEIN-BOUND LECITHIN TO LYSOLECITHIN INDUCED BY SNAKE-VENOM PHOSPHOLIPASE A.	Lecithins	32-40	phospholipase A and acyltransferase 1	Homo sapiens	80-95
13742848-0	1961	Studies of the use of dihexanoylleithin and other lecithins as substrates for phospholipase A, with addendum on aspects of micelle properties of dihexanoyllecithin.	Lecithins	50-59	phospholipase A and acyltransferase 1	Homo sapiens	78-93
33861588-5	2021	In vitro, MPO-mediated damage of lipid-free apoA-I impaired its ability to promote cellular cholesterol efflux by the ABCA1 pathway, whereas oxidation to lipid-associated apoA-I inhibited lecithin:cholesterol acyltransferase activation, two key steps in reverse cholesterol transport.	Lecithins	188-196	myeloperoxidase	Homo sapiens	10-13
13367036-0	1956	Observations on the incorporation in vivo of palmitic acid-1-C14 and oleic acid-1-C14 into lecithins.	Lecithins	91-100	mediator complex subunit 25	Homo sapiens	75-81
33930417-2	2021	The multifunctional PPL strain exhibited enhanced growth and increased production of biosurfactants upon lecithin supplementation and consequently exhibited potent anti-CMV activity.	Lecithins	105-113	periplakin	Homo sapiens	20-23
33930417-3	2021	The enhanced anti-CMV activity of the lecithin-supplemented PPL culture could be attributed to the antiviral effect as well as to the upregulation of plant defense-related genes.	Lecithins	38-46	periplakin	Homo sapiens	60-63
33930417-4	2021	Treatment with pure commercial fengycins elicited a defense response against CMV in pepper plants; this effect was similar to that observed upon treatment with the lecithin-supplemented PPL culture.	Lecithins	164-172	periplakin	Homo sapiens	186-189
13367036-0	1956	Observations on the incorporation in vivo of palmitic acid-1-C14 and oleic acid-1-C14 into lecithins.	Lecithins	91-100	mediator complex subunit 25	Homo sapiens	54-60
16743245-1	1923	The Oxygenase of Bach and Chodat: Function of Lecithins in Respiration.	Lecithins	46-55	acyl-CoA thioesterase 7	Homo sapiens	17-21
33867422-1	2021	Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin.	Lecithins	149-157	lecithin-cholesterol acyltransferase	Homo sapiens	0-36
33867422-1	2021	Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin.	Lecithins	149-157	lecithin-cholesterol acyltransferase	Homo sapiens	38-42
33861588-5	2021	In vitro, MPO-mediated damage of lipid-free apoA-I impaired its ability to promote cellular cholesterol efflux by the ABCA1 pathway, whereas oxidation to lipid-associated apoA-I inhibited lecithin:cholesterol acyltransferase activation, two key steps in reverse cholesterol transport.	Lecithins	188-196	apolipoprotein A1	Homo sapiens	44-50
33861588-5	2021	In vitro, MPO-mediated damage of lipid-free apoA-I impaired its ability to promote cellular cholesterol efflux by the ABCA1 pathway, whereas oxidation to lipid-associated apoA-I inhibited lecithin:cholesterol acyltransferase activation, two key steps in reverse cholesterol transport.	Lecithins	188-196	apolipoprotein A1	Homo sapiens	171-177
32861770-0	2020	Lipoprotein imitating nanoparticles: Lecithin coating binds ApoE and mediates non-lysosomal uptake leading to transcytosis over the blood-brain barrier.	Lecithins	37-45	apolipoprotein E	Homo sapiens	60-64
33279714-2	2021	In such systems lecithin serves as stabilizing as well as functionalizing agent and enables the adsorptive binding of apolipoprotein E3 (ApoE) as potential drug targeting ligand.	Lecithins	16-24	apolipoprotein E	Homo sapiens	118-135
33279714-2	2021	In such systems lecithin serves as stabilizing as well as functionalizing agent and enables the adsorptive binding of apolipoprotein E3 (ApoE) as potential drug targeting ligand.	Lecithins	16-24	apolipoprotein E	Homo sapiens	137-141
33631212-6	2021	We demonstrate in mice that the sequestration of retinyl esters by the enzyme lecithin: retinol acyl transferase (LRAT) is central for this process.	Lecithins	78-86	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)	Mus musculus	114-118
33279714-12	2021	The ApoE mediated effects of transcytosis at an in vitro BBB model by bypassing lysosomes were reproduced in even stronger quantities than with a ChOl core, proving lecithin coating as transferable strategy to disguise various NPs with a certain lipophilicity as lipoproteins.	Lecithins	165-173	apolipoprotein E	Homo sapiens	4-8
33254967-2	2021	Beeswax (BW) and lecithin played predominant roles in microemulsion and in the average diameter, zeta potential, encapsulation efficiency of NGF and RA and release kinetics of NGF- and RA-loaded Ln5-P4/ASLNs (Ln5-P4/NGF-RA-ASLNs).	Lecithins	17-25	nerve growth factor	Homo sapiens	141-144
33254967-2	2021	Beeswax (BW) and lecithin played predominant roles in microemulsion and in the average diameter, zeta potential, encapsulation efficiency of NGF and RA and release kinetics of NGF- and RA-loaded Ln5-P4/ASLNs (Ln5-P4/NGF-RA-ASLNs).	Lecithins	17-25	nerve growth factor	Homo sapiens	176-179
33254967-2	2021	Beeswax (BW) and lecithin played predominant roles in microemulsion and in the average diameter, zeta potential, encapsulation efficiency of NGF and RA and release kinetics of NGF- and RA-loaded Ln5-P4/ASLNs (Ln5-P4/NGF-RA-ASLNs).	Lecithins	17-25	nerve growth factor	Homo sapiens	176-179
32861770-6	2020	Lecithin coating was proven to stabilize the NPs in isotonic saline solution and to bind ApoE in a highly efficient way.	Lecithins	0-8	apolipoprotein E	Homo sapiens	89-93
31233714-4	2019	Phospholipase A2 (PLA2) riched in wound exudate was served tactfully as a trigger to hydrolyze lecithin in liposome and destroy the liposomes to release drug.	Lecithins	95-103	phospholipase A2 group IB	Homo sapiens	0-16
33169920-8	2021	CONCLUSIONS: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-gamma expression and adiponectin production.	Lecithins	74-82	peroxisome proliferator activated receptor gamma	Mus musculus	222-232
33169920-8	2021	CONCLUSIONS: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-gamma expression and adiponectin production.	Lecithins	74-82	adiponectin, C1Q and collagen domain containing	Mus musculus	248-259
31044628-3	2020	Double-loaded liposomes encapsulating lycopene beta-CD complex were prepared using soy lecithin, cholesterol, and beta-CD by thin film hydration method.	Lecithins	87-95	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	47-54
32348213-4	2020	OBJECTIVE: To evaluate the effect of curcumin nanoemulsions prepared with lecithin modified with medium-chain fatty acids as an emulsifier, on the expression of the Cdk4, Ccne2, Casp8 and Cldn4 genes involved in the carcinogenesis process in K14E6 transgenic mice.	Lecithins	74-82	cyclin-dependent kinase 4	Mus musculus	165-169
32367585-1	2020	The recent report (1) that the increased cholesterol and lecithin content of hepatic bile after administration of the complex lipopeptide myrcludex B is attributable to its binding to the Sodium Taurocholate Cotransporting Polypeptide (NTCP) , which causes a re-distribution of canalicular bile transport to the peri-central zone appears to conflict with a previous study (2).	Lecithins	57-65	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	188-234
32441466-3	2020	In order to improve the encapsulation efficiency of BMP7 and avoid damage by organic solvents, BMP7 was modified and protected using the biosurfactant soybean lecithin.	Lecithins	159-167	bone morphogenetic protein 7	Homo sapiens	95-99
32450892-0	2020	ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity.	Lecithins	69-77	apolipoprotein E	Homo sapiens	0-4
32450892-0	2020	ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity.	Lecithins	69-77	apolipoprotein C3	Homo sapiens	9-17
31590861-2	2020	In this context, this study evaluated the effect of lecithin on the characteristics of chitosan (CHI) and chondroitin sulfate (CS) nanoparticles, when applied in curcumin (Curc) release.	Lecithins	52-60	citrate synthase	Homo sapiens	127-129
31590861-6	2020	The final characteristics of NPs were directly influenced by lecithin addition, exhibiting enhanced encapsulation efficiency of curcumin (131.8 mug curcumin per mg CHI/CS/Lecithin/Curc NPs).	Lecithins	61-69	citrate synthase	Homo sapiens	164-170
31233714-4	2019	Phospholipase A2 (PLA2) riched in wound exudate was served tactfully as a trigger to hydrolyze lecithin in liposome and destroy the liposomes to release drug.	Lecithins	95-103	phospholipase A2 group IB	Homo sapiens	18-22
30062563-4	2018	The GFA-loaded solid nanolipids (GFASN) with a core/shell structure, composed of Poloxamer 188, lecithin, and medium-chain fatty acid, were prepared using a high-pressure homogenate emulsification method.	Lecithins	96-104	glutamine fructose-6-phosphate transaminase 1	Mus musculus	4-7
31048191-4	2019	It is generally accepted that both CD44 and CD133 are gastric cancer stem cells markers, we hereby developed CD44/CD133-ATRA-PLPN (CD44 and CD133 antibody-conjugated all-trans retinoic acid-loaded poly(lactide-co-glycolide)-lecithin-PEG nanoparticles) to target both CD133+ and CD44+ gastric cancer stem cells.	Lecithins	224-232	prominin 1	Homo sapiens	114-119
31048191-4	2019	It is generally accepted that both CD44 and CD133 are gastric cancer stem cells markers, we hereby developed CD44/CD133-ATRA-PLPN (CD44 and CD133 antibody-conjugated all-trans retinoic acid-loaded poly(lactide-co-glycolide)-lecithin-PEG nanoparticles) to target both CD133+ and CD44+ gastric cancer stem cells.	Lecithins	224-232	prominin 1	Homo sapiens	114-119
31048191-4	2019	It is generally accepted that both CD44 and CD133 are gastric cancer stem cells markers, we hereby developed CD44/CD133-ATRA-PLPN (CD44 and CD133 antibody-conjugated all-trans retinoic acid-loaded poly(lactide-co-glycolide)-lecithin-PEG nanoparticles) to target both CD133+ and CD44+ gastric cancer stem cells.	Lecithins	224-232	prominin 1	Homo sapiens	114-119
30429888-6	2018	P-(MIs)n were mixed with DSPE-PEG2000, angiopep-2-DSPE-PEG2000 and lecithin to self-assemble ALP-(MIs)n through a single-step nanoprecipitation method.	Lecithins	67-75	ATHS	Homo sapiens	93-96
29718725-1	2018	Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (LsbMDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX.	Lecithins	153-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-55
29718725-1	2018	Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (LsbMDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX.	Lecithins	153-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-61
29096289-3	2018	The total PUFA, C18:2n-6 and C18:3n-3 in subcutaneous fat were increased by lecithin but the effect of lecithin was dependent of l-carnitine where supplementation of lecithin together with l-carnitine decreased total PUFA, C18:2n-6 and C18:3n-3.	Lecithins	103-111	Polyunsaturated fatty acid percentage	Sus scrofa	217-221
29453250-4	2018	Here, we report that after 9-cis-retinal administration to lecithin:retinol acyltransferase-deficient (Lrat-/- ) mice, the drug was rapidly absorbed and then cleared within 1 to 2 hours.	Lecithins	59-67	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)	Mus musculus	103-107
30956867-0	2019	Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1beta via an anti-inflammatory mechanism.	Lecithins	41-49	interleukin 1 beta	Homo sapiens	94-102
29859232-3	2018	Herein we report a novel acid-sensitive sheddable PEGylated solid-lipid nanoparticle formulation of TNF-alpha-siRNA, AS-TNF-alpha-siRNA-SLNs, prepared by incorporating lipophilized TNF-alpha-siRNA into solid-lipid nanoparticles composed of biocompatible lipids such as lecithin and cholesterol.	Lecithins	269-277	tumor necrosis factor	Mus musculus	100-109
29096289-3	2018	The total PUFA, C18:2n-6 and C18:3n-3 in subcutaneous fat were increased by lecithin but the effect of lecithin was dependent of l-carnitine where supplementation of lecithin together with l-carnitine decreased total PUFA, C18:2n-6 and C18:3n-3.	Lecithins	76-84	Polyunsaturated fatty acid percentage	Sus scrofa	10-14
29096289-3	2018	The total PUFA, C18:2n-6 and C18:3n-3 in subcutaneous fat were increased by lecithin but the effect of lecithin was dependent of l-carnitine where supplementation of lecithin together with l-carnitine decreased total PUFA, C18:2n-6 and C18:3n-3.	Lecithins	103-111	Polyunsaturated fatty acid percentage	Sus scrofa	217-221
28959007-8	2017	Phospholipids with lecithin derived from PUFA fortified eggs may be a valuable dietary supplement in prophylaxis of hypertension and in patients with hypertension, however, this requires further studies on humans.	Lecithins	19-27	pumilio RNA binding family member 3	Homo sapiens	41-45
28985138-1	2018	OBJECTIVE: Soy milk is enriched with nutritive elements such as proteins, unsaturated fatty acids, lecithins, isoflavones, mineral substances, free amino acids, and polypeptides.	Lecithins	99-108	Weaning weight-maternal milk	Bos taurus	15-19
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Lecithins	28-36	integrin subunit beta 1	Homo sapiens	162-176
28559520-5	2017	RESULTS: Our results showed a correlation of lecithin concentration with size, zeta potential, and loading capacity of RIF-NPs.	Lecithins	45-53	ras homolog family member F, filopodia associated	Homo sapiens	119-122
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Lecithins	28-36	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	197-202
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Lecithins	28-36	inhibitor of growth family member 2	Homo sapiens	232-235
25108331-4	2014	Bivalent metal ions can be arranged in the following sequence by their ability to activate PLD in the hydrolysis of lecithin and lysolecithin: Ca2+&gt;Sr2+&gt;Ba2+&gt;Mg2+.	Lecithins	116-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-94
30592856-4	2017	In the study of the molecular properties of the lipase of pancreatic juice before and after molecular docking, it was found that one molecule of lecithin didn"t fully block the active site of the enzyme.	Lecithins	145-153	lipase, endothelial	Mus musculus	48-54
30592856-5	2017	For complete inactivation of lipase, two molecules of lecithin or one molecule of allicin were required (Epot.	Lecithins	54-62	lipase, endothelial	Mus musculus	29-35
27338483-0	2016	Dietary Lecithin Decreases Skeletal Muscle COL1A1 and COL3A1 Gene Expression in Finisher Gilts.	Lecithins	8-16	collagen type I alpha 1	Sus scrofa	43-49
27338483-0	2016	Dietary Lecithin Decreases Skeletal Muscle COL1A1 and COL3A1 Gene Expression in Finisher Gilts.	Lecithins	8-16	collagen type III alpha 1 chain	Sus scrofa	54-60
27338483-3	2016	Lecithin treatment down-regulated Type I (alpha1) procollagen (COL1A1) and Type III (alpha1) procollagen (COL3A1) mRNA expression ( p &lt; 0.05, respectively), indicating a decrease in the precursors for collagen synthesis.	Lecithins	0-8	collagen type I alpha 1	Sus scrofa	63-69
27338483-3	2016	Lecithin treatment down-regulated Type I (alpha1) procollagen (COL1A1) and Type III (alpha1) procollagen (COL3A1) mRNA expression ( p &lt; 0.05, respectively), indicating a decrease in the precursors for collagen synthesis.	Lecithins	0-8	collagen type III alpha 1 chain	Sus scrofa	106-112
27338483-5	2016	Decreased matrix metalloproteinase-1 (MMP-1) mRNA expression may reflect a positive regulatory response to the reduced collagen synthesis in muscle from the pigs fed lecithin ( p = 0.035).	Lecithins	166-174	interstitial collagenase	Sus scrofa	10-36
27338483-5	2016	Decreased matrix metalloproteinase-1 (MMP-1) mRNA expression may reflect a positive regulatory response to the reduced collagen synthesis in muscle from the pigs fed lecithin ( p = 0.035).	Lecithins	166-174	interstitial collagenase	Sus scrofa	38-43
27398452-2	2016	Modified solvent emulsification-evaporation method was optimized to obtain Tmx-PLN, composed of chitosan and lecithin, of 169.66 +- 4.84 nm particle size.	Lecithins	109-117	thioredoxin related transmembrane protein 1	Homo sapiens	75-78
27398452-2	2016	Modified solvent emulsification-evaporation method was optimized to obtain Tmx-PLN, composed of chitosan and lecithin, of 169.66 +- 4.84 nm particle size.	Lecithins	109-117	phospholamban	Homo sapiens	79-82
24650780-2	2014	Like DGL, YLLIP2 was able to hydrolyze TAG droplets covered by a lecithin monolayer, while HPL was not directly active on that substrate.	Lecithins	65-73	lipase F, gastric type	Canis lupus familiaris	5-8
27073851-11	2016	As a result of the lecithin injections, there was a redistribution of the mRNA content of genes encoding actin monomer- and filament-binding proteins in the direction of increasing actin polymerization and filament stability; the mRNA content of Arpc3 and Lcp1 increased by 3- and 5-fold, respectively, but the levels of Tmod1 and Svil decreased by 2- and 5-fold, respectively.	Lecithins	19-27	actin related protein 2/3 complex, subunit 3	Rattus norvegicus	246-251
27073851-11	2016	As a result of the lecithin injections, there was a redistribution of the mRNA content of genes encoding actin monomer- and filament-binding proteins in the direction of increasing actin polymerization and filament stability; the mRNA content of Arpc3 and Lcp1 increased by 3- and 5-fold, respectively, but the levels of Tmod1 and Svil decreased by 2- and 5-fold, respectively.	Lecithins	19-27	lymphocyte cytosolic protein 1	Rattus norvegicus	256-260
27073851-11	2016	As a result of the lecithin injections, there was a redistribution of the mRNA content of genes encoding actin monomer- and filament-binding proteins in the direction of increasing actin polymerization and filament stability; the mRNA content of Arpc3 and Lcp1 increased by 3- and 5-fold, respectively, but the levels of Tmod1 and Svil decreased by 2- and 5-fold, respectively.	Lecithins	19-27	tropomodulin 1	Rattus norvegicus	321-326
27073851-11	2016	As a result of the lecithin injections, there was a redistribution of the mRNA content of genes encoding actin monomer- and filament-binding proteins in the direction of increasing actin polymerization and filament stability; the mRNA content of Arpc3 and Lcp1 increased by 3- and 5-fold, respectively, but the levels of Tmod1 and Svil decreased by 2- and 5-fold, respectively.	Lecithins	19-27	supervillin	Rattus norvegicus	331-335
27073851-14	2016	Lecithin injection resulted in an increase in the Actn1 and Actn4 mRNA content in group "C+L" by 1.5-fold and more than 2-fold, respectively, compared with the levels in group "C".	Lecithins	0-8	actinin, alpha 1	Rattus norvegicus	50-55
27073851-14	2016	Lecithin injection resulted in an increase in the Actn1 and Actn4 mRNA content in group "C+L" by 1.5-fold and more than 2-fold, respectively, compared with the levels in group "C".	Lecithins	0-8	actinin alpha 4	Rattus norvegicus	60-65
27073851-16	2016	Thus, lecithin prevented the reduction of Actn1 and Actn4 mRNA and the migration of ACTN4 from the cortical cytoskeleton to the cytoplasm.	Lecithins	6-14	actinin, alpha 1	Rattus norvegicus	42-47
27073851-16	2016	Thus, lecithin prevented the reduction of Actn1 and Actn4 mRNA and the migration of ACTN4 from the cortical cytoskeleton to the cytoplasm.	Lecithins	6-14	actinin alpha 4	Rattus norvegicus	52-57
27073851-16	2016	Thus, lecithin prevented the reduction of Actn1 and Actn4 mRNA and the migration of ACTN4 from the cortical cytoskeleton to the cytoplasm.	Lecithins	6-14	actinin alpha 4	Rattus norvegicus	84-89
26595232-1	2016	Superoxide dismutase covalently bound to four lecithin molecules (PC-SOD) has been found to have beneficial therapeutic effects in animal models of various diseases.	Lecithins	46-54	superoxide dismutase 1	Homo sapiens	69-72
24334268-12	2014	On the whole, this work provided key parameters for the formulation of liposomes using enzymatic PLD technology, to produce lecithins enriched in different proportions of PS and esterified with various types of fatty acids depending on the initial lecithin source.	Lecithins	124-133	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
24867597-1	2014	Superoxide dismutase covalently bound to four lecithin molecules (PC-SOD) is known to be retained in circulating blood for a prolonged period and has a high affinity for cells, resulting in beneficial therapeutic effects in animal disease models.	Lecithins	46-54	superoxide dismutase 1	Homo sapiens	69-72
24867597-2	2014	In this study, we evaluated the interaction of PC-SOD with biological components, such as serum proteins and cells, to clarify the mechanism underlying the improved pharmacokinetics of SOD induced by lecithin chemical modification (lecithinization).	Lecithins	200-208	superoxide dismutase 1	Homo sapiens	50-53
24867597-2	2014	In this study, we evaluated the interaction of PC-SOD with biological components, such as serum proteins and cells, to clarify the mechanism underlying the improved pharmacokinetics of SOD induced by lecithin chemical modification (lecithinization).	Lecithins	200-208	superoxide dismutase 1	Homo sapiens	185-188
24736652-1	2014	LCAT (lecithin:cholesterol acyltransferase) catalyzes the transacylation of a fatty acid of lecithin to cholesterol, generating a cholesteryl ester and lysolecithin.	Lecithins	6-14	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
24591829-0	2014	Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.	Lecithins	62-70	epithelial cell adhesion molecule	Homo sapiens	0-33
22348223-3	2012	This work reports the preparation and characterization of auto-assembled chitosan/lecithin nanoparticles loaded with AST and AST complexed with beta-cyclodextrin (beta-CD) to boost its antimalarial activity.	Lecithins	82-90	beta-carotene oxygenase 1	Mus musculus	163-170
23639419-2	2013	Many reports exist on PLD-mediated synthesis of natural and tailor-made PLs with functional head groups, from easily available lecithin or phosphatidylcholine.	Lecithins	127-135	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	22-25
23516040-1	2013	Existing kinetic data of cholesteryl ester formation by lecithin:cholesterol acyltransferase in discoidal high-density lipoproteins with 34 mutations of apoA-I that involved all putative helices were grouped by cluster analysis into four noncoincident regions with mutations both without any functional impairment and with profound isolated (V- and K-mutations) or common (VK-mutations) effect on V(max)(app) and K(m)(app).	Lecithins	56-64	apolipoprotein A1	Homo sapiens	153-159
23656565-4	2013	Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO).	Lecithins	58-66	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	230-234
23656565-4	2013	Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO).	Lecithins	58-66	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	239-243
23044153-2	2013	The results of antioxidant protective effect on lecithin liposome peroxidation induced by 2,2"-azobis(2-methylpropionamidine) dihydrochloride revealed that the MRPs heated for 120 min and 180 min showed much higher inhibitory activity than chitosan or MRP heated for 60 min.	Lecithins	48-56	ATP binding cassette subfamily C member 1	Homo sapiens	160-163
22448206-1	2012	The cell expression of Tip60 combined with site-directed mutagenesis analysis was used to identify the glutamine 324 residue as the lecithin binding (Concanavalin A; Con A) site.	Lecithins	132-140	lysine acetyltransferase 5	Homo sapiens	23-28
22467021-3	2012	In the model, BALB/c mice were sensitized orally for three weeks with ovalbumin (OVA) in linoleic acid/lecithin emulsion, followed immediately by intraperitoneal injection of sodium salicylate.	Lecithins	103-111	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	70-79
22815052-1	2012	In this study, natural lecithin was incorporated into cholesterol-poly(epsilon-caprolactone) (Chol-PCL) by solution blending in order to modify the performance of the hydrophobic and bio-inert PCL.	Lecithins	23-31	PHD finger protein 1	Homo sapiens	99-102
22815052-1	2012	In this study, natural lecithin was incorporated into cholesterol-poly(epsilon-caprolactone) (Chol-PCL) by solution blending in order to modify the performance of the hydrophobic and bio-inert PCL.	Lecithins	23-31	PHD finger protein 1	Homo sapiens	193-196
22815052-8	2012	The preliminary results indicate that electrospun Chol-PCL/lecithin scaffolds show improved hemocompatibility and cytocompatibility compared with neat Chol-PCL, and combining the Chol-PCL/lecithin fibrous scaffold with MSCs and ECs with well controlled distribution is a promising strategy for constructing TEVGs.	Lecithins	59-67	PHD finger protein 1	Homo sapiens	55-58
22815052-8	2012	The preliminary results indicate that electrospun Chol-PCL/lecithin scaffolds show improved hemocompatibility and cytocompatibility compared with neat Chol-PCL, and combining the Chol-PCL/lecithin fibrous scaffold with MSCs and ECs with well controlled distribution is a promising strategy for constructing TEVGs.	Lecithins	188-196	PHD finger protein 1	Homo sapiens	55-58
23024474-0	2011	Effect of Lecithin on d-Galactosamine Induced Hepatotoxicity Through Mitochondrial Pathway Involving Bcl-2 and Bax.	Lecithins	10-18	BCL2, apoptosis regulator	Rattus norvegicus	101-106
23024474-0	2011	Effect of Lecithin on d-Galactosamine Induced Hepatotoxicity Through Mitochondrial Pathway Involving Bcl-2 and Bax.	Lecithins	10-18	BCL2 associated X, apoptosis regulator	Rattus norvegicus	111-114
23024474-5	2011	Increases in the liver enzyme levels by d-GalN were significantly inhibited by pretreatment with lecithin.	Lecithins	97-105	galanin and GMAP prepropeptide	Rattus norvegicus	42-46
23024474-7	2011	In addition, the disruption of mitochondrial membrane, up regulation of Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with lecithin.	Lecithins	205-213	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
23024474-7	2011	In addition, the disruption of mitochondrial membrane, up regulation of Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with lecithin.	Lecithins	205-213	BCL2, apoptosis regulator	Rattus norvegicus	99-104
23024474-7	2011	In addition, the disruption of mitochondrial membrane, up regulation of Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with lecithin.	Lecithins	205-213	galanin and GMAP prepropeptide	Rattus norvegicus	135-139
21182941-3	2011	In the present study, using ovalbumin (OVA) as a model antigen conjugated onto nanoparticles engineered from lecithin/glyceryl monostearate-in-water emulsions, we prepared OVA-nanoparticles of 230 nm and 708 nm.	Lecithins	109-117	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	172-175
19429292-2	2009	In such fabricated composite scaffolds (abbreviated "PLGA/Lec-SMS"), the introduction of lecithin component has been proven capable of largely enhancing Gentamicin (GS) and protein (Bovine Serum Albumin) encapsulation efficiency.	Lecithins	89-97	C-C motif chemokine ligand 16	Homo sapiens	58-61
19694503-10	2010	The optimized SLN was prepared by 80 mg of cetyl alcohol, 10 mg of lecithin, acetone:DCM ratio (1:2), 30-second sonication, 3% Tween 20, and a mixing rate of 800 rpm.	Lecithins	67-75	sarcolipin	Rattus norvegicus	14-17
19369053-0	2010	Dietary supplementation with soybean lecithin increases pulmonary PAF bioactivity in asthmatic rats.	Lecithins	37-45	PCNA clamp associated factor	Rattus norvegicus	66-69
19369053-4	2010	Thus, this work aimed to investigate if dietary supplementation with soybean lecithin (SL), a source of PUFAs, increases lipid peroxidation and PAF bioactivity in lungs of asthmatic Wistar rats.	Lecithins	77-85	PCNA clamp associated factor	Rattus norvegicus	144-147
21845078-1	2011	Catalase-loaded solid lipid nanoparticles (SLNs) were prepared by the double emulsion method (w/o/w) and solvent evaporation techniques, using acetone/methylene chloride (1:1) as an organic solvent, lecithin and triglyceride as oil phase and Poloxmer 188 as a surfactant.	Lecithins	199-207	catalase	Homo sapiens	0-8
21845078-2	2011	The optimized SLN was prepared by lecithin: triglyceride ratio (5%), 20-second + 30-second sonication, and 2% Poloxmer 188.	Lecithins	34-42	sarcolipin	Homo sapiens	14-17
23105905-1	2010	To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induced toxicity in freshly isolated rat hepatocytes and animal models.	Lecithins	15-23	galanin and GMAP prepropeptide	Rattus norvegicus	85-89
19264360-2	2009	In this paper, a BSA (bovine serum albumin)-lecithin liposome system was used to study the nature of different forms of iron, including methemoglobin, hemin and ferric citrate, in catalyzing H(2)O(2)-nitrite system to oxidize protein and lipid as well as nitrate protein.	Lecithins	44-52	albumin	Homo sapiens	29-42
19264360-2	2009	In this paper, a BSA (bovine serum albumin)-lecithin liposome system was used to study the nature of different forms of iron, including methemoglobin, hemin and ferric citrate, in catalyzing H(2)O(2)-nitrite system to oxidize protein and lipid as well as nitrate protein.	Lecithins	44-52	hemoglobin subunit gamma 2	Homo sapiens	136-149
19288019-2	2009	Lecithin contains fatty acids identified as the peroxisome proliferator-activated receptor (PPAR) agonists.	Lecithins	0-8	peroxisome proliferator activated receptor alpha	Mus musculus	48-90
19288019-2	2009	Lecithin contains fatty acids identified as the peroxisome proliferator-activated receptor (PPAR) agonists.	Lecithins	0-8	peroxisome proliferator activated receptor alpha	Mus musculus	92-96