PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 9197499-3 1997 We focused our attention on the determination of HPV infection, the detection of p53 protein, and c-erbB-2 protein in 24 biopsy specimens of LP. leucylproline 141-143 erb-b2 receptor tyrosine kinase 2 Homo sapiens 98-106 8609410-6 1996 Biopsies from 87.5% of the LP patients, but only 38.5% of the MF patients, demonstrated VCAM-1 on vascular endothelium. leucylproline 27-29 vascular cell adhesion molecule 1 Homo sapiens 88-94 8810238-8 1996 The high affinity of ICG for only Apo-B could explain the reason why ICG mainly bound to beta-Lp among several serum Lps, because large amounts of Apo-B are included in beta-Lp but a little in other serum Lps. leucylproline 94-96 apolipoprotein B Homo sapiens 34-39 8831991-9 1996 A comparison of LP and steady state BM CD34+ cells in paired samples from each individual, showed a higher proportion of primitive immunophenotypes (CDw90+, HLA-DR-, CD45RA-, CD33-) among LP CD34+ cells. leucylproline 16-18 CD33 molecule Homo sapiens 175-179 8788480-1 1996 In mice injected with formalin into the hindpaw, the 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, equipotently inhibited the early phase (EP) and late phase (LP) of licking. leucylproline 165-167 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 53-68 7590706-4 1995 In this study, polymerase chain reaction (PCR) and Southern blot analysis were used to show the presence of JH/bcl-1 translocation in a typical case of LP of the gastrointestinal tract. leucylproline 152-154 cyclin D1 Homo sapiens 111-116 7768792-6 1995 The addition of specific dipeptides, such as leucylproline and prolylleucine, to the growth medium negatively affected the expression of the prtP-gusA fusions. leucylproline 45-58 prtP Lactococcus lactis 141-145 8563167-1 1995 Looptail (Lp) is a mutation on the distal portion of mouse Chromosome (Chr) 1 that affects neurulation in mouse and is phenotypically expressed by appearance of an open neural tube along the entire antero-posterior axis of the embryo (craniorachischisis). leucylproline 10-12 VANGL planar cell polarity 2 Mus musculus 0-8 8563167-2 1995 Nhlh1, a member of the basic helix-loop-helix family of transcription factors, is expressed in the developing neural tube in structures affected by the Lp mutation and has been regionally assigned to the distal part of mouse Chr 1. leucylproline 152-154 nescient helix loop helix 1 Mus musculus 0-5 8563167-7 1995 Nevertheless, Nhlh1 is the Chr 1 marker most tightly linked to Lp identified to date and can, therefore, be used as an excellent entry probe to clone the Lp region. leucylproline 63-65 nescient helix loop helix 1 Mus musculus 14-19 8563167-7 1995 Nevertheless, Nhlh1 is the Chr 1 marker most tightly linked to Lp identified to date and can, therefore, be used as an excellent entry probe to clone the Lp region. leucylproline 154-156 nescient helix loop helix 1 Mus musculus 14-19 24301381-1 1995 Restoration of a high potential (HP) form of cytochrome b-559 (Cyt b-559) from a low potential (LP) form was the primary process in the reconstitution of O2-evolving center during the photoreactivation of Tris-inactivated chloroplasts. leucylproline 96-98 mitochondrially encoded cytochrome b Homo sapiens 45-57 24301381-1 1995 Restoration of a high potential (HP) form of cytochrome b-559 (Cyt b-559) from a low potential (LP) form was the primary process in the reconstitution of O2-evolving center during the photoreactivation of Tris-inactivated chloroplasts. leucylproline 96-98 mitochondrially encoded cytochrome b Homo sapiens 63-68 7659444-3 1995 In mice, the NK1 antagonist, CP 99,994, preferentially (inhibitory dose50 (ID50) = 4.4) inhibited the late phase (LP) as compared to the early phase (EP) (16.1) of formalin-induced licking (FIL). leucylproline 114-116 tachykinin 1 Mus musculus 13-16 7659444-11 1995 The NK2 antagonist, SR 48,966, mimicked NK1 antagonists in preferentially inhibiting the LP (7.7) as compared to the EP (26.9) of FIL. leucylproline 89-91 killer cell lectin-like receptor, subfamily A, member 3 Mus musculus 4-7 7659444-11 1995 The NK2 antagonist, SR 48,966, mimicked NK1 antagonists in preferentially inhibiting the LP (7.7) as compared to the EP (26.9) of FIL. leucylproline 89-91 tachykinin 1 Mus musculus 40-43 7659444-16 1995 Finally, the NSAIDs, indomethacin and ibuprofen, the BK2 antagonist, Hoe 140 and the nitric oxide synthase (NOS) inhibitors, L-NAME and 7 nitroindazole, inhibited the LP (but not the EP) of FIL and (except for L-NAME) also reduced writhing: in contrast, they did not evoke ataxia and were inactive in the TF procedures. leucylproline 167-169 bradykinin receptor, beta 2 Mus musculus 53-56 7659444-16 1995 Finally, the NSAIDs, indomethacin and ibuprofen, the BK2 antagonist, Hoe 140 and the nitric oxide synthase (NOS) inhibitors, L-NAME and 7 nitroindazole, inhibited the LP (but not the EP) of FIL and (except for L-NAME) also reduced writhing: in contrast, they did not evoke ataxia and were inactive in the TF procedures. leucylproline 167-169 nitric oxide synthase 1, neuronal Mus musculus 85-106 8303091-2 1993 We demonstrate the occurrence of NADPH-dependent CCl4-promoted lipid peroxidation processes (LP) leading to malondialdehyde (MDA) formation in liver microsomal and nuclear preparations from OM and SD rats which do not correlate with the cancer susceptibility of both strains. leucylproline 93-95 C-C motif chemokine ligand 4 Rattus norvegicus 49-53 8171056-9 1994 In Experiment 4, testosterone and dihydrotestosterone pellets implanted in LP-exposed CX males prevented the CX-induced rise in IGF-1; testosterone implants also reduced IGF-1 levels in CX males treated with progesterone. leucylproline 75-77 insulin-like growth factor I Mesocricetus auratus 128-133 8171056-9 1994 In Experiment 4, testosterone and dihydrotestosterone pellets implanted in LP-exposed CX males prevented the CX-induced rise in IGF-1; testosterone implants also reduced IGF-1 levels in CX males treated with progesterone. leucylproline 75-77 insulin-like growth factor I Mesocricetus auratus 170-175 7771708-7 1995 Daily mean (+/- SD) colostrum and milk PTHrP concentrations ranged from 3.25 (+/- 3.23) to 4.69 (+/- 1.36) nmol/L in LP cows and 2.74 (+/- 0.5) to 5.95 (+/- 0.33) nmol/L in HP cows. leucylproline 117-119 parathyroid hormone like hormone Bos taurus 39-44 7771708-8 1995 In all cows of the HP group and most cows of the LP group, milk PTHrP concentration was highest in the day-1 sample. leucylproline 49-51 parathyroid hormone like hormone Bos taurus 64-69 7771708-10 1995 In contrast, there was a negative relation between milk PTHrP and milk Ca(tot) concentrations in LP cows (r = -0.3285, P < 0.02). leucylproline 97-99 parathyroid hormone like hormone Bos taurus 56-61 7526888-9 1994 The present study thus demonstrates, for the first time, that apo-D secretion is inversely correlated to cell proliferation and cell density in the absence as well as in the presence of androgens in both LP and HP LNCaP human prostate cancer cells. leucylproline 204-206 apolipoprotein D Homo sapiens 62-67 8465813-5 1993 The activity of plasma renin (3.0 +/- 0.5 ng/mL/min on SP v 1.1 +/- 0.1 ng/mL/min on LP) was significantly (P < 0.02) lower on LP intake. leucylproline 85-87 renin Rattus norvegicus 23-28 8465813-5 1993 The activity of plasma renin (3.0 +/- 0.5 ng/mL/min on SP v 1.1 +/- 0.1 ng/mL/min on LP) was significantly (P < 0.02) lower on LP intake. leucylproline 130-132 renin Rattus norvegicus 23-28 8465813-6 1993 In contrast, glomerular renin content (22.9 +/- 0.7 ng/micrograms protein on SP v 32.3 +/- 1.4 ng/micrograms protein on LP) was significantly (P < 0.01) higher on the LP diet. leucylproline 120-122 renin Rattus norvegicus 24-29 8465813-6 1993 In contrast, glomerular renin content (22.9 +/- 0.7 ng/micrograms protein on SP v 32.3 +/- 1.4 ng/micrograms protein on LP) was significantly (P < 0.01) higher on the LP diet. leucylproline 170-172 renin Rattus norvegicus 24-29 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 116-118 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 1534646-11 1992 In group LP, mean HR increased less than in group SP (56 +/- 8 to 62 +/- 14 beats.min-1), whereas MAP and CI declined significantly. leucylproline 9-11 CD59 molecule (CD59 blood group) Homo sapiens 82-87 1632463-8 1992 This is in spite of the fact that RS cells expressing B-cell-associated antigen CD20 were detectable in 7/8 cases of LP HD and 6/24 cases of NS and MC HD with monoclonal antibody L26. leucylproline 117-119 keratin 20 Homo sapiens 80-84 8327031-3 1993 It is furthermore characterized by a marked increase of apo CIII, which is disproportionate with respect to the increase of apo CII and the variation of apo E, in relation with an accumulation of Lp B-CIII (and also Lp B-E and Lp B-C-E for hemodialyzed patients) in the whole spectrum of low density lipoproteins. leucylproline 196-198 apolipoprotein C3 Homo sapiens 56-64 8327031-3 1993 It is furthermore characterized by a marked increase of apo CIII, which is disproportionate with respect to the increase of apo CII and the variation of apo E, in relation with an accumulation of Lp B-CIII (and also Lp B-E and Lp B-C-E for hemodialyzed patients) in the whole spectrum of low density lipoproteins. leucylproline 196-198 apolipoprotein C2 Homo sapiens 56-63 8327031-3 1993 It is furthermore characterized by a marked increase of apo CIII, which is disproportionate with respect to the increase of apo CII and the variation of apo E, in relation with an accumulation of Lp B-CIII (and also Lp B-E and Lp B-C-E for hemodialyzed patients) in the whole spectrum of low density lipoproteins. leucylproline 196-198 apolipoprotein E Homo sapiens 153-158 1351039-3 1992 Single-strand conformation polymorphism analysis revealed a variant in the transthyretin gene, which was found on sequencing to be a T----C transversion at position 2 of codon 55, corresponding to a Leu----Pro substitution. leucylproline 199-209 transthyretin Homo sapiens 75-88 1736307-3 1992 Amino acid sequence analysis revealed that the N terminus of mature Kex2 protease is created by a potentially autoproteolytic cleavage at Lys108-Arg109, prior to the domain homologous to subtilisin, followed by trimming of Leu-Pro and Val-Pro dipeptides by the Ste13 dipeptidyl aminopeptidase. leucylproline 223-230 kexin KEX2 Saccharomyces cerevisiae S288C 68-72 1517103-0 1992 Hb Bab-Saadoun or alpha 2 beta (2)48(CD7)Leu----Pro, a mildly unstable variant found in an Arabian boy from Tunisia. leucylproline 41-51 CD7 molecule Homo sapiens 37-40 1830268-14 1991 E and PRL also increased the expression of RWB and M-40.3 messenger RNA, although the responses in DP and LP were somewhat different. leucylproline 106-108 prolactin Rattus norvegicus 6-9 1283920-2 1992 All stages of the process were characterized by LP activation which in animals of all groups (except rabbits having the acute stage of arthritis) is accompanied by compensatory increase of superoxide dismutase and ceruloplasmin activity. leucylproline 48-50 ceruloplasmin Oryctolagus cuniculus 214-227 1283920-4 1992 Decrease in alpha 1-proteinase inhibitor activity at the stage of osteitis with reactive synovitis can be caused by the influence of LP products. leucylproline 133-135 alpha-1-antiproteinase F Oryctolagus cuniculus 12-40 2127844-3 1990 LP intensity showed correlation with change in the ratio of phospholipid fractions and change in ATPase activity. leucylproline 0-2 dynein axonemal heavy chain 8 Homo sapiens 97-103 2041532-4 1991 Furthermore investigating the correlation between sex and histopathological variety it was found a significant prevalence of the GGC in the male sex, whereas the correlations within the age"s sets are the followings: the LP is more prevalent in the IV age set (46-60 years), whereas the GP is more prevalent in the III age set (31-45 years) and in the V age set (greater than 60 years). leucylproline 221-223 gamma-glutamylcyclotransferase Homo sapiens 129-132 1865208-5 1991 The changes in intracranial CSF volume were studied in 20 patients who had LP. leucylproline 75-77 colony stimulating factor 2 Homo sapiens 28-31 1865208-6 1991 Total intracranial CSF volume was reduced in 19 of the 20 patients 24 hours after LP (range -1.8 mls to -158.6 mls). leucylproline 82-84 colony stimulating factor 2 Homo sapiens 19-22 2122951-2 1990 Among 37 patients treated with tissue-type plasminogen activator(t-PA treated group), LP were recorded in 2 patients (5%). leucylproline 86-88 plasminogen activator, tissue type Homo sapiens 65-69 2122951-5 1990 Angiographic examination following t-PA infusion revealed that the incidence of LP was 0% and 40% in patients with patent and closed infarct-related coronary artery respectively. leucylproline 80-82 plasminogen activator, tissue type Homo sapiens 35-39 2361454-7 1990 Using Arg-Pro-; Leu-Pro; and Pro-Pro-4-nitroanilide as substrates the activity of a marker enzyme dipeptidyl peptidase IV, DP IV, EC. leucylproline 16-23 dipeptidyl peptidase 4 Homo sapiens 98-121 2373757-0 1990 Cranial effects of retinoic acid in the loop-tail (Lp) mutant mouse. leucylproline 51-53 VANGL planar cell polarity 2 Mus musculus 40-49 2155256-8 1990 The new Leu----Pro substitution, which is predicted to alter the higher order of TBG structure, is probably responsible for the TBG-CD phenotype of the individual studied and two other families with TBG-CD. leucylproline 8-18 serpin family A member 7 Homo sapiens 81-84 2155256-8 1990 The new Leu----Pro substitution, which is predicted to alter the higher order of TBG structure, is probably responsible for the TBG-CD phenotype of the individual studied and two other families with TBG-CD. leucylproline 8-18 serpin family A member 7 Homo sapiens 128-131 2155256-8 1990 The new Leu----Pro substitution, which is predicted to alter the higher order of TBG structure, is probably responsible for the TBG-CD phenotype of the individual studied and two other families with TBG-CD. leucylproline 8-18 serpin family A member 7 Homo sapiens 128-131 26380151-9 2015 Cells directly rosetting LP cells are positive for CD57 and/or for two markers of T-follicular helper (TFH) cells, PD-1 and BCL-6. leucylproline 25-27 MHC class I antigen 1 Sus scrofa 115-119 26380151-9 2015 Cells directly rosetting LP cells are positive for CD57 and/or for two markers of T-follicular helper (TFH) cells, PD-1 and BCL-6. leucylproline 25-27 BCL6 transcription repressor Sus scrofa 124-129 34571152-5 2022 Further, LP increased thyroid hormone receptor-alpha/deiodinase-2 (TRalpha/Dio-2), estrogen receptor-alpha (ERalpha)/aromatase and insulin receptor/glucose transporter-4 (IR/GLUT-4) expressions in ovary. leucylproline 9-11 thyroid hormone receptor alpha Mesocricetus auratus 22-52 34571152-5 2022 Further, LP increased thyroid hormone receptor-alpha/deiodinase-2 (TRalpha/Dio-2), estrogen receptor-alpha (ERalpha)/aromatase and insulin receptor/glucose transporter-4 (IR/GLUT-4) expressions in ovary. leucylproline 9-11 LOW QUALITY PROTEIN: type II iodothyronine deiodinase Mesocricetus auratus 75-80 34571152-5 2022 Further, LP increased thyroid hormone receptor-alpha/deiodinase-2 (TRalpha/Dio-2), estrogen receptor-alpha (ERalpha)/aromatase and insulin receptor/glucose transporter-4 (IR/GLUT-4) expressions in ovary. leucylproline 9-11 estrogen receptor Mesocricetus auratus 83-106 34571152-5 2022 Further, LP increased thyroid hormone receptor-alpha/deiodinase-2 (TRalpha/Dio-2), estrogen receptor-alpha (ERalpha)/aromatase and insulin receptor/glucose transporter-4 (IR/GLUT-4) expressions in ovary. leucylproline 9-11 estrogen receptor Mesocricetus auratus 108-115 34582949-5 2022 Celsr3-deficient neuroblasts exhibit aberrant branching of LP, de novo LP formation, and decreased growth rate of microtubules (MT). leucylproline 59-61 cadherin, EGF LAG seven-pass G-type receptor 3 Mus musculus 0-6 34582949-5 2022 Celsr3-deficient neuroblasts exhibit aberrant branching of LP, de novo LP formation, and decreased growth rate of microtubules (MT). leucylproline 71-73 cadherin, EGF LAG seven-pass G-type receptor 3 Mus musculus 0-6 34612769-3 2021 The highest EE (76.96%) was found when LS was prepared using 0.5%, w/v of CE conjugate and 60 micromol mL-1 of LP (CELP-60-0.5) (p < 0.05). leucylproline 111-113 carboxyl ester lipase pseudogene Homo sapiens 115-119 34670452-5 2022 RESULTS: LP significantly attenuated I/R-induced cardiomyocyte apoptosis, infarct size, and secretion of creatine kinase-MB, lactate dehydrogenase and cardiac troponin I. leucylproline 9-11 troponin I3, cardiac type Rattus norvegicus 151-169 34670452-9 2022 CONCLUSION: HSP90 markedly contributes to LP cardioprotection by inhibiting inflammatory responsesand C5a/NF-kappaB signaling , ultimately attenuating I/R-induced cardiomyocyte apoptosis by suppressing the proapoptotic factor Bax, and inducing the anti-apoptotic factor Bcl2. leucylproline 42-44 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 12-17 34670452-9 2022 CONCLUSION: HSP90 markedly contributes to LP cardioprotection by inhibiting inflammatory responsesand C5a/NF-kappaB signaling , ultimately attenuating I/R-induced cardiomyocyte apoptosis by suppressing the proapoptotic factor Bax, and inducing the anti-apoptotic factor Bcl2. leucylproline 42-44 complement C5 Rattus norvegicus 102-105 34670452-9 2022 CONCLUSION: HSP90 markedly contributes to LP cardioprotection by inhibiting inflammatory responsesand C5a/NF-kappaB signaling , ultimately attenuating I/R-induced cardiomyocyte apoptosis by suppressing the proapoptotic factor Bax, and inducing the anti-apoptotic factor Bcl2. leucylproline 42-44 BCL2 associated X, apoptosis regulator Rattus norvegicus 226-229 34670452-9 2022 CONCLUSION: HSP90 markedly contributes to LP cardioprotection by inhibiting inflammatory responsesand C5a/NF-kappaB signaling , ultimately attenuating I/R-induced cardiomyocyte apoptosis by suppressing the proapoptotic factor Bax, and inducing the anti-apoptotic factor Bcl2. leucylproline 42-44 BCL2, apoptosis regulator Rattus norvegicus 270-274 34903161-7 2021 Examination of the expression profile revealed that the GNAQ expression was low in the estrous females both under LP and SP conditions, but high expression of GNAQ was observed in the anestrous females under LP conditions. leucylproline 114-116 guanine nucleotide-binding protein G(q) subunit alpha Ovis aries 56-60 34698110-10 2021 Circulating factors, including cytokines such as interleukin 13, may play a role in the pathophysiology of LP and needs to be studied further in future larger studies. leucylproline 107-109 interleukin 13 Homo sapiens 49-63 35627888-3 2022 We found that the high-ER-intensity areas were spreading from the eastern to the central and western regions, and the patterns of LP transited from high in the north and low in the south to high in the west and low in the east. leucylproline 130-132 epiregulin Homo sapiens 23-25 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 tumor necrosis factor superfamily member 11 Gallus gallus 23-74 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 tumor necrosis factor superfamily member 11 Gallus gallus 76-81 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 tumor necrosis factor superfamily member 11 Gallus gallus 96-101 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 TNF receptor superfamily member 11b Gallus gallus 105-120 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 TNF receptor superfamily member 11b Gallus gallus 122-125 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 sclerostin Gallus gallus 166-176 34309436-8 2022 The mRNA expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and ratio of RANKL to osteoprotegerin (OPG) were upregulated (P<0.05), and that of sclerostin and OPG was downregulated (P<0.05) in the LP group in comparison to hens in the C group. leucylproline 219-221 TNF receptor superfamily member 11b Gallus gallus 181-184 34780089-6 2022 Although liver PAM was lower in offspring fed the LP diet, as well as female offspring, brain PAM was not affected by diet or sex. leucylproline 50-52 peptidylglycine alpha-amidating monooxygenase Mus musculus 15-18 34780089-9 2022 Anxiety-like behaviours were decreased in offspring fed the LP diet and were correlated with markers of LP diet consumption including increased liver 13 C-PAM, warranting further investigation. leucylproline 60-62 peptidylglycine alpha-amidating monooxygenase Mus musculus 155-158 34780089-9 2022 Anxiety-like behaviours were decreased in offspring fed the LP diet and were correlated with markers of LP diet consumption including increased liver 13 C-PAM, warranting further investigation. leucylproline 104-106 peptidylglycine alpha-amidating monooxygenase Mus musculus 155-158 34780089-10 2022 Altogether, our results indicate that DNL from dietary sugars is a compensatory mechanism to maintain brain PAM in response to a LP diet. leucylproline 129-131 peptidylglycine alpha-amidating monooxygenase Mus musculus 108-111 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 eyes absent homolog 3 Ovis aries 48-52 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 thyrotropin subunit beta Ovis aries 54-58 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 homeobox protein SIX1 Ovis aries 60-64 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 L-dopachrome tautomerase Ovis aries 66-69 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 vitelline membrane outer layer protein 1 homolog Ovis aries 71-75 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 amphiregulin Ovis aries 77-81 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 histone-lysine N-methyltransferase SUV39H2 Ovis aries 83-90 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 histone-lysine N-methyltransferase EZH2 Ovis aries 96-100 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 chromogranin-A Ovis aries 152-156 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 protein c-Fos Ovis aries 158-161 34414222-6 2021 The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. leucylproline 12-14 suppressor of cytokine signaling 3 Ovis aries 163-168 35627888-4 2022 There was a negative correlation spatially between ER and LP. leucylproline 58-60 epiregulin Homo sapiens 51-53 35627888-5 2022 LP could inhibit the increase in ER intensity, while the continuously increasing ER intensity could restrict LP through the competitive behavior from the "race to the bottom" to the "race to the top" among local governments. leucylproline 0-2 epiregulin Homo sapiens 33-35 35627888-5 2022 LP could inhibit the increase in ER intensity, while the continuously increasing ER intensity could restrict LP through the competitive behavior from the "race to the bottom" to the "race to the top" among local governments. leucylproline 109-111 epiregulin Homo sapiens 81-83 35627888-6 2022 The effect of ER restricting LP was significant from 2008 to 2013 and prominent in the east, which was dominated by "race to the top" competition, while LP had a greater inhibitory effect on ER in the central and western regions, which preferred to obtain tax revenues from pollution-intensive industries. leucylproline 29-31 epiregulin Homo sapiens 14-16 35627888-6 2022 The effect of ER restricting LP was significant from 2008 to 2013 and prominent in the east, which was dominated by "race to the top" competition, while LP had a greater inhibitory effect on ER in the central and western regions, which preferred to obtain tax revenues from pollution-intensive industries. leucylproline 153-155 epiregulin Homo sapiens 191-193 35584094-6 2022 RESULTS: LP group showed significantly higher BMI, older age, and lower plasma albumin concentration compared with those of SP group. leucylproline 9-11 albumin Homo sapiens 79-86 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 immunoglobulin heavy constant alpha Mus musculus 178-181 35464168-3 2022 UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control. leucylproline 183-185 interleukin 1 alpha Homo sapiens 46-55 35464168-3 2022 UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control. leucylproline 183-185 matrix metallopeptidase 1 Homo sapiens 76-81 35464168-3 2022 UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control. leucylproline 183-185 matrix metallopeptidase 1 Homo sapiens 108-113 35464168-4 2022 In the presence of LP at concentrations of 1 and 10 mug/mL, both the secretion of IL-1alpha and protein levels of MMP-1 in human keratinocyte cells significantly reduced. leucylproline 19-21 thrombopoietin Mus musculus 56-58 35464168-4 2022 In the presence of LP at concentrations of 1 and 10 mug/mL, both the secretion of IL-1alpha and protein levels of MMP-1 in human keratinocyte cells significantly reduced. leucylproline 19-21 interleukin 1 alpha Homo sapiens 82-91 35464168-4 2022 In the presence of LP at concentrations of 1 and 10 mug/mL, both the secretion of IL-1alpha and protein levels of MMP-1 in human keratinocyte cells significantly reduced. leucylproline 19-21 matrix metallopeptidase 1 Homo sapiens 114-119 35464168-6 2022 Our results with three different skin cells accordingly showed that LP may help maintain skin health through decreased levels of MMP-1 activity via its anti-inflammatory properties. leucylproline 68-70 matrix metallopeptidase 1 Homo sapiens 129-134 35394491-7 2022 Results: The LP/DT ratio was 3.02 +- 0.52 in patients with NF1 and 2.63 +- 0.31 in controls (P = 0.02). leucylproline 13-15 neurofibromin 1 Homo sapiens 59-62 35394491-11 2022 Conclusions: This study confirms the dysfunction of the RPE in patients with NF1, involving a lower DT and a corresponding higher LP/DT ratio. leucylproline 130-132 neurofibromin 1 Homo sapiens 77-80 35012431-2 2022 Herein, we aimed to determine how Lnc-NEAT1 promotes LP development. leucylproline 53-55 nuclear paraspeckle assembly transcript 1 Homo sapiens 38-43 35506310-2 2022 Here, we report that LP-induced ABA accumulation promotes Pi uptake in an ABA INSENSITIVE5 (ABI5)-dependent manner in Arabidopsis thaliana. leucylproline 21-23 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 74-90 35506310-2 2022 Here, we report that LP-induced ABA accumulation promotes Pi uptake in an ABA INSENSITIVE5 (ABI5)-dependent manner in Arabidopsis thaliana. leucylproline 21-23 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 92-96 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 0-2 phosphate transporter 1;1 Arabidopsis thaliana 98-126 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 0-2 phosphate transporter 1;1 Arabidopsis thaliana 128-134 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 0-2 Glycosyl hydrolase superfamily protein Arabidopsis thaliana 183-200 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 0-2 Glycosyl hydrolase superfamily protein Arabidopsis thaliana 202-205 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 336-338 phosphate transporter 1;1 Arabidopsis thaliana 98-126 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 336-338 phosphate transporter 1;1 Arabidopsis thaliana 128-134 35506310-4 2022 LP-induced ABA accumulation and expression of two major high-affinity phosphate transporter genes PHOSPHATE TRANSPORTER1;1/1;4 (PHT1;1/1;4) were severely impaired in a mutant lacking BETA-GLUCOSIDASE1 (BG1), which converts conjugated ABA to active ABA, and the mutant had shorter root and less Pi content than the wild-type plant under LP. leucylproline 336-338 Glycosyl hydrolase superfamily protein Arabidopsis thaliana 183-200 35041887-8 2022 The motility index of H. contortus was significantly reduced (p < 0.001) during the first 8 h of LP exposure, both in larvae (lowest index 8.3% with LP at 1 mg mL-1) and female adults (lowest index 20% with LP at 500 mug mL-1; index 40% with LP at 1 mg mL-1). leucylproline 97-99 L1 cell adhesion molecule Mus musculus 160-164 35041887-8 2022 The motility index of H. contortus was significantly reduced (p < 0.001) during the first 8 h of LP exposure, both in larvae (lowest index 8.3% with LP at 1 mg mL-1) and female adults (lowest index 20% with LP at 500 mug mL-1; index 40% with LP at 1 mg mL-1). leucylproline 97-99 L1 cell adhesion molecule Mus musculus 221-225 35041887-8 2022 The motility index of H. contortus was significantly reduced (p < 0.001) during the first 8 h of LP exposure, both in larvae (lowest index 8.3% with LP at 1 mg mL-1) and female adults (lowest index 20% with LP at 500 mug mL-1; index 40% with LP at 1 mg mL-1). leucylproline 97-99 L1 cell adhesion molecule Mus musculus 253-257 35041887-8 2022 The motility index of H. contortus was significantly reduced (p < 0.001) during the first 8 h of LP exposure, both in larvae (lowest index 8.3% with LP at 1 mg mL-1) and female adults (lowest index 20% with LP at 500 mug mL-1; index 40% with LP at 1 mg mL-1). leucylproline 149-151 L1 cell adhesion molecule Mus musculus 221-225 35041887-8 2022 The motility index of H. contortus was significantly reduced (p < 0.001) during the first 8 h of LP exposure, both in larvae (lowest index 8.3% with LP at 1 mg mL-1) and female adults (lowest index 20% with LP at 500 mug mL-1; index 40% with LP at 1 mg mL-1). leucylproline 149-151 L1 cell adhesion molecule Mus musculus 253-257 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 interleukin 2 Mus musculus 93-106 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 interleukin 2 Mus musculus 108-112 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 interleukin 6 Mus musculus 115-119 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 tumor necrosis factor Mus musculus 121-148 34999342-3 2022 Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor alpha (TNF-alpha), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. leucylproline 13-15 tumor necrosis factor Mus musculus 150-159 2675988-3 1989 Insulin, whether administered in vivo or during perfusion, increased myocardial glucose utilization [GU] and lactate production [LP]. leucylproline 129-131 insulin Sus scrofa 0-7 2675988-4 1989 Stimulation of GU and LP by insulin exposure in vivo persisted for at least 1 h during perfusions after insulin was removed. leucylproline 22-24 insulin Sus scrofa 28-35 2675988-5 1989 Exogenous lactate (0.5 mM) diminished insulin-stimulated GU and LP; and was used as a substrate at 1.25 mM. leucylproline 64-66 insulin Sus scrofa 38-45 2651333-4 1989 The suppressive activity of SSF on LP response to PHA was significantly decreased by the pretreatment of responder lymphocytes with PSK. leucylproline 35-37 peter pan homolog Homo sapiens 28-31 2651333-4 1989 The suppressive activity of SSF on LP response to PHA was significantly decreased by the pretreatment of responder lymphocytes with PSK. leucylproline 35-37 TAO kinase 2 Homo sapiens 132-135 3622657-5 1987 Although elevated erythropoietin levels were found in each LP, preabsorption with antierythropoietin IgG did not alter its capacity to enhance human burst formation. leucylproline 59-61 erythropoietin Homo sapiens 18-32 3595804-6 1987 Using SDS-PAGE and immunoblot and dot-blot techniques, we found that the major proteins associated with LP were albumin and fibronectin, whereas apoB and apoE were present in lower amounts. leucylproline 104-106 fibronectin 1 Homo sapiens 124-135 2947883-2 1986 A monoclonal anti-IL-2 receptor (R) antibody (MoAb), TU69, which blocked LP responses of IL 2-dependent T-cell lines, also blocked SC induction by T-cell clones, but completely failed to inhibit SC generation in MLC or with IL-2. leucylproline 73-75 interleukin 2 receptor subunit beta Homo sapiens 18-31 3038761-1 1987 Lysophosphatidylcholine (LC), platelet activating factor (PAF) and its precursor lysophosphatidalcholine (LP) enhance O-2-release by polymorphonuclear leucocytes (PMNL) triggered by PMA whereas lysophospholipids with other polar headgroups fail to do so. leucylproline 106-108 PCNA clamp associated factor Homo sapiens 58-61 2947883-2 1986 A monoclonal anti-IL-2 receptor (R) antibody (MoAb), TU69, which blocked LP responses of IL 2-dependent T-cell lines, also blocked SC induction by T-cell clones, but completely failed to inhibit SC generation in MLC or with IL-2. leucylproline 73-75 interleukin 2 Homo sapiens 89-93 2947883-2 1986 A monoclonal anti-IL-2 receptor (R) antibody (MoAb), TU69, which blocked LP responses of IL 2-dependent T-cell lines, also blocked SC induction by T-cell clones, but completely failed to inhibit SC generation in MLC or with IL-2. leucylproline 73-75 interleukin 2 Homo sapiens 18-22 6222114-8 1983 Whereas absorption of the anti-LP with PBM failed to remove the capacity to inhibit the generation of ISC, anti-LP-mediated inhibition of responsiveness could be reversed by the addition of crude M phi culture supernatants or a variety of highly purified interleukin 1 (IL 1) preparations, but not by T cell supernatants. leucylproline 112-114 interleukin 1 alpha Homo sapiens 255-268 6709646-2 1984 The enzyme also catalyzes the cleavage of arginine from des-[Arg9]-bradykinin and the hydrolysis of several X-proline dipeptides including L-arginyl-L-proline, L-leucyl-L-proline, and L-alanyl-L-proline. leucylproline 160-178 kininogen 1 Homo sapiens 67-77 6222114-8 1983 Whereas absorption of the anti-LP with PBM failed to remove the capacity to inhibit the generation of ISC, anti-LP-mediated inhibition of responsiveness could be reversed by the addition of crude M phi culture supernatants or a variety of highly purified interleukin 1 (IL 1) preparations, but not by T cell supernatants. leucylproline 112-114 interleukin 1 alpha Homo sapiens 270-274 6222114-9 1983 These results indicate anti-LP inhibits human B cell activation by removing the requisite M phi-derived factor IL 1 and also confirm that IL 1 plays an essential role in B cell proliferation and the generation of ISC in man. leucylproline 28-30 interleukin 1 alpha Homo sapiens 111-115 6222114-9 1983 These results indicate anti-LP inhibits human B cell activation by removing the requisite M phi-derived factor IL 1 and also confirm that IL 1 plays an essential role in B cell proliferation and the generation of ISC in man. leucylproline 28-30 interleukin 1 alpha Homo sapiens 138-142 6807176-4 1982 Purified human LP stimulated isolated mouse hepatocytes in vitro to synthesize SAA in a dose-responsive manner. leucylproline 15-17 serum amyloid A cluster Mus musculus 79-82 7439989-4 1980 The ability of LP to induce hepatic synthesis of haptoglobin and C-reactive protein was so markedly enhanced by intracerebroventricular injection, however, that a role of the central nervous system in mediating or in modifying in an important way a non-neural mechanism for this mediation must be postulated. leucylproline 15-17 haptoglobin Oryctolagus cuniculus 49-60 7439989-4 1980 The ability of LP to induce hepatic synthesis of haptoglobin and C-reactive protein was so markedly enhanced by intracerebroventricular injection, however, that a role of the central nervous system in mediating or in modifying in an important way a non-neural mechanism for this mediation must be postulated. leucylproline 15-17 C-reactive protein Oryctolagus cuniculus 65-83 212376-5 1978 Upon repeat testing, many patients gave reproducibly positive LP responses to tumor HMP. leucylproline 62-64 inner membrane mitochondrial protein Homo sapiens 84-87 659595-8 1978 These observations suggest that the concommitance of fever, elevated serum or urine lysozyme and hypoferremia may, in part, be explained by the interaction of LP and peripheral blood neutrophils. leucylproline 159-161 lysozyme Homo sapiens 84-92 923728-1 1977 Adult loop-tail heterozygotes (Lp/+) from a stock of Lp-mice which consistently fail to show head wobbling exhibit normal brain morphology with respect to size and shape of lateral ventricles and nearby nuclei. leucylproline 31-33 VANGL planar cell polarity 2 Mus musculus 6-15 32360599-11 2020 Inoculation by LJM17 from LP elicited Dsg1-cross-reactive IgG4 antibodies may lead to FS in genetically predisposed individuals. leucylproline 26-28 desmoglein 1 Homo sapiens 38-42 33086592-4 2020 The plasma leptin concentration was higher (p < 0.001) in the FR group than in the LP and SP groups, while insulin concentration was higher in the SP group than in the LP and FR groups. leucylproline 83-85 leptin Sus scrofa 11-17 32919636-1 2020 Lanreotide peptide (LP) has high affinity to somatostatin receptors like SSTR2 and is commonly used in the treatment of neuro-endocrine tumors. leucylproline 20-22 somatostatin receptor 2 Homo sapiens 73-78 32919636-8 2020 Our studies demonstrate that LP coated AuNP can be used as an effective platform to selectively target SSTR2 positive cancer cells for combination therapy approaches involving gold nanoparticles. leucylproline 29-31 somatostatin receptor 2 Rattus norvegicus 103-108 33115535-12 2020 Measurement of LP functional activity in plasma from MASP-2-/- mice revealed the absence of LP functional activity using a C4b deposition assay. leucylproline 15-17 mannan-binding lectin serine peptidase 2 Mus musculus 53-59 33115535-13 2020 The LP critically contributes to the post-traumatic inflammatory pathology following TBI with the highest degree of protection achieved through the absence of the LP key enzyme MASP-2, underlining a therapeutic utility of MASP-2 targeting in TBI. leucylproline 4-6 mannan-binding lectin serine peptidase 2 Mus musculus 222-228 32002629-6 2020 We further revealed that OGFOD1 was directly targeted by miR-1224-5p, which was significantly down-regulated in LP. leucylproline 112-114 2-oxoglutarate and iron dependent oxygenase domain containing 1 Homo sapiens 25-31 32814619-9 2020 Both FP and LP significantly increased both extra and intra cellular ALP activity. leucylproline 12-14 ATHS Homo sapiens 69-72 32814619-12 2020 Moreover, LP extracts enhanced the production and secretion of odontogenic markers: dentin matrix protein 1 (DMP-1) and osteopontin. leucylproline 10-12 dentin matrix acidic phosphoprotein 1 Homo sapiens 84-107 32814619-12 2020 Moreover, LP extracts enhanced the production and secretion of odontogenic markers: dentin matrix protein 1 (DMP-1) and osteopontin. leucylproline 10-12 dentin matrix acidic phosphoprotein 1 Homo sapiens 109-114 32814619-12 2020 Moreover, LP extracts enhanced the production and secretion of odontogenic markers: dentin matrix protein 1 (DMP-1) and osteopontin. leucylproline 10-12 secreted phosphoprotein 1 Homo sapiens 120-131 32192320-2 2020 The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats. leucylproline 117-119 toll-like receptor 2 Rattus norvegicus 179-184 32192320-2 2020 The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats. leucylproline 117-119 tumor necrosis factor Rattus norvegicus 193-202 32565851-7 2020 We observed that LP exerted antiaging effects in aging rats following the activation of AMPK/SIRT1. leucylproline 17-19 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 88-92 32565851-7 2020 We observed that LP exerted antiaging effects in aging rats following the activation of AMPK/SIRT1. leucylproline 17-19 sirtuin 1 Rattus norvegicus 93-98 32565851-9 2020 Therefore, LP can alleviate inflammation of the testis via the AMPK/SIRT1/NF-kappaB pathway in aging rats. leucylproline 11-13 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 63-67 32565851-9 2020 Therefore, LP can alleviate inflammation of the testis via the AMPK/SIRT1/NF-kappaB pathway in aging rats. leucylproline 11-13 sirtuin 1 Rattus norvegicus 68-73 32002629-6 2020 We further revealed that OGFOD1 was directly targeted by miR-1224-5p, which was significantly down-regulated in LP. leucylproline 112-114 microRNA 1224 Homo sapiens 57-65 32002629-7 2020 Overexpression of the miR-1224-5p suppressed OGFOD1-induced cell proliferation and viability, and promoted apoptosis of LP. leucylproline 120-122 microRNA 1224 Homo sapiens 22-30 32002629-9 2020 In confederation of the central involvement of OGFOD1 in LP progression, targeting the miR-1224-5p/OGFOD1 pathway might provide a novel strategy for LP treatment. leucylproline 57-59 2-oxoglutarate and iron dependent oxygenase domain containing 1 Homo sapiens 47-53 32002629-9 2020 In confederation of the central involvement of OGFOD1 in LP progression, targeting the miR-1224-5p/OGFOD1 pathway might provide a novel strategy for LP treatment. leucylproline 57-59 microRNA 1224 Homo sapiens 87-95 32002629-9 2020 In confederation of the central involvement of OGFOD1 in LP progression, targeting the miR-1224-5p/OGFOD1 pathway might provide a novel strategy for LP treatment. leucylproline 149-151 2-oxoglutarate and iron dependent oxygenase domain containing 1 Homo sapiens 47-53 32002629-9 2020 In confederation of the central involvement of OGFOD1 in LP progression, targeting the miR-1224-5p/OGFOD1 pathway might provide a novel strategy for LP treatment. leucylproline 149-151 microRNA 1224 Homo sapiens 87-95 32002629-9 2020 In confederation of the central involvement of OGFOD1 in LP progression, targeting the miR-1224-5p/OGFOD1 pathway might provide a novel strategy for LP treatment. leucylproline 149-151 2-oxoglutarate and iron dependent oxygenase domain containing 1 Homo sapiens 99-105 31408100-14 2019 CONCLUSION: The majority of P/LP variants in patients with CACNA1C-mediated LQT8 cluster in an SH3-binding domain of the cytosolic II-III loop. leucylproline 30-32 calcium voltage-gated channel subunit alpha1 C Homo sapiens 59-66 32193077-1 2020 The first decade of event-related potential (ERP) research had established that the most consistent correlates of the onset of visual consciousness are the early visual awareness negativity (VAN), a posterior negative component in the N2 time range, and the late positivity (LP), an anterior positive component in the P3 time range. leucylproline 275-277 ETS transcription factor ELK3 Homo sapiens 45-48 30967639-1 2020 Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies and rodent models. leucylproline 66-68 mannose-binding lectin (protein C) 2 Mus musculus 0-22 30967639-1 2020 Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies and rodent models. leucylproline 66-68 mannose-binding lectin (protein C) 2 Mus musculus 24-27 30967639-11 2020 WT and MBL-C-/- ischemic mice had higher LP activity in plasma and, accordingly, higher levels of C3 deposition in the brain than MBL-A-/- and MBL-/- mice. leucylproline 41-43 mannose-binding lectin (protein C) 2 Mus musculus 7-12 30967639-11 2020 WT and MBL-C-/- ischemic mice had higher LP activity in plasma and, accordingly, higher levels of C3 deposition in the brain than MBL-A-/- and MBL-/- mice. leucylproline 41-43 mannose-binding lectin (protein C) 2 Mus musculus 7-10 32597809-4 2020 RESULTS: Rare, possibly pathogenic heterozygous LRP10 variants were present in three patients: p.Gly453Serin a patient with mixed Alzheimer"s disease (AD)/Lewy body disease (LBD), p.Arg151Cys in a DLB patient, and p.Gly326Asp in an AD patient without LP. leucylproline 251-253 LDL receptor related protein 10 Homo sapiens 48-53 32175536-3 2020 Results showed that LP increased the thymus index, spleen index, and serum IgA level in cyclophosphamide (CTX)-treated mice. leucylproline 20-22 immunoglobulin heavy constant alpha Mus musculus 75-78 32175536-5 2020 The underlying mechanism comes down to the facts as follow: LP increased intestinal cytokines expression and TGFbetaRII that is associated with pathways of IgA class switch recombination (CSR). leucylproline 60-62 immunoglobulin heavy constant alpha Mus musculus 156-159 32175536-6 2020 By improving protein expression of mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) and integrin alpha4beta7, LP was beneficial to gut homing of IgA+ plasma cells. leucylproline 115-117 mucosal vascular addressin cell adhesion molecule 1 Mus musculus 35-77 32175536-6 2020 By improving protein expression of mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) and integrin alpha4beta7, LP was beneficial to gut homing of IgA+ plasma cells. leucylproline 115-117 immunoglobulin heavy constant alpha Mus musculus 150-153 32175536-7 2020 LP increased IgA, polymeric immunoglobulin receptor (pIgR), and secretory component (SC) to fortify the SIgA secretion. leucylproline 0-2 polymeric immunoglobulin receptor Mus musculus 53-57 31408100-14 2019 CONCLUSION: The majority of P/LP variants in patients with CACNA1C-mediated LQT8 cluster in an SH3-binding domain of the cytosolic II-III loop. leucylproline 30-32 calcium voltage-gated channel subunit alpha1 C Homo sapiens 76-80 31471503-3 2019 METHODS: Identification of LP was based on staining for alpha-synuclein in multiple brain regions in a sample of 211 men. leucylproline 27-29 synuclein alpha Homo sapiens 56-71 31469600-7 2019 This activity was enhanced when coincubated with recombinant LP recognition molecules MBL and ficolin-3. leucylproline 61-63 mannose binding lectin 2 Homo sapiens 86-89 31469600-7 2019 This activity was enhanced when coincubated with recombinant LP recognition molecules MBL and ficolin-3. leucylproline 61-63 ficolin 3 Homo sapiens 94-103 31469600-8 2019 Recombinant MAP-1 fusion proteins, combined with recombinant LP recognition molecules to target sites of inflammation, represent a novel and effective therapeutic approach involving the initiation and the central and terminal effector functions of the complement cascade.-Perez-Alos, L., Bayarri-Olmos, R., Skjoedt, M.-O., Garred, P. Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade. leucylproline 61-63 MBL associated serine protease 1 Homo sapiens 344-349 31469600-8 2019 Recombinant MAP-1 fusion proteins, combined with recombinant LP recognition molecules to target sites of inflammation, represent a novel and effective therapeutic approach involving the initiation and the central and terminal effector functions of the complement cascade.-Perez-Alos, L., Bayarri-Olmos, R., Skjoedt, M.-O., Garred, P. Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade. leucylproline 61-63 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 350-354 31469600-8 2019 Recombinant MAP-1 fusion proteins, combined with recombinant LP recognition molecules to target sites of inflammation, represent a novel and effective therapeutic approach involving the initiation and the central and terminal effector functions of the complement cascade.-Perez-Alos, L., Bayarri-Olmos, R., Skjoedt, M.-O., Garred, P. Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade. leucylproline 61-63 MBL associated serine protease 1 Homo sapiens 344-349 31469600-8 2019 Recombinant MAP-1 fusion proteins, combined with recombinant LP recognition molecules to target sites of inflammation, represent a novel and effective therapeutic approach involving the initiation and the central and terminal effector functions of the complement cascade.-Perez-Alos, L., Bayarri-Olmos, R., Skjoedt, M.-O., Garred, P. Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade. leucylproline 61-63 CD55 molecule (Cromer blood group) Homo sapiens 364-368 31106687-5 2019 LP was defined as eGFR < 30 ml/min/1.73 m2. leucylproline 0-2 epidermal growth factor receptor Homo sapiens 18-22 31103887-13 2019 Peak of serum insulin concentration was greater (P = 0.04) and serum insulin concentration tended to decrease (P = 0.08) more rapidly in LP compared with HP steers after glucose infusion. leucylproline 137-139 insulin Bos taurus 69-76 30459599-8 2018 The compounds including Taurine, Paeonol, and Ginsenoside Rb1 in LP can activate PI3K/AKT pathway. leucylproline 65-67 RB transcriptional corepressor 1 Rattus norvegicus 58-61 31491946-4 2019 The rise of O2- and H2O2 photoproduction in the PSII preparations in the course of the disassembly of the WOC correlated with the increase in the fraction of the low-potential (LP) Cyt b559. leucylproline 178-180 immunoglobulin kappa variable 1D-39 Homo sapiens 12-25 31058287-4 2019 RESULTS: We demonstrate that complement recognition molecules C1q, CL-11, and murine ficolin-A bind the enterococcus and drive the CP and the LP in human and mouse. leucylproline 142-144 complement component 1, q subcomponent, alpha polypeptide Mus musculus 62-65 31058287-4 2019 RESULTS: We demonstrate that complement recognition molecules C1q, CL-11, and murine ficolin-A bind the enterococcus and drive the CP and the LP in human and mouse. leucylproline 142-144 ficolin A Mus musculus 85-94 31121264-4 2019 tshb, dio2 and gnrh mRNA levels were further increased by 2.5 weeks of LP at 38 C. Temperature sensitive trpm8, but not trpv4, bdnf or adcyap1 also showed LP-induced expression at 22 C. Concomitant changes in dnmt3b and tet2 mRNA expressions further suggested epigenetic modification of temperature influence on photoperiodic responses. leucylproline 71-73 thyroid stimulating hormone subunit beta Homo sapiens 0-4 31121264-4 2019 tshb, dio2 and gnrh mRNA levels were further increased by 2.5 weeks of LP at 38 C. Temperature sensitive trpm8, but not trpv4, bdnf or adcyap1 also showed LP-induced expression at 22 C. Concomitant changes in dnmt3b and tet2 mRNA expressions further suggested epigenetic modification of temperature influence on photoperiodic responses. leucylproline 156-158 thyroid stimulating hormone subunit beta Homo sapiens 0-4 31133247-2 2019 The expression level of CREB1 mRNA in the ovaries of the HP group was higher than in the LP group (P < 0.05). leucylproline 89-91 cyclic AMP-responsive element-binding protein 1 Ovis aries 24-29 30606148-7 2019 One LP variant in BRCA1 had not been previously described, c.4153_4154delCT (p.Leu1385Ilefs*5). leucylproline 4-6 BRCA1 DNA repair associated Homo sapiens 18-23 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 C-reactive protein Rattus norvegicus 76-94 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 tumor necrosis factor Rattus norvegicus 105-132 31087820-13 2019 All methods of stimulation triggered shifts in LP site from the central SAN to caudal pacemaker regions, which were positive for HCN4 and received uniform cholinergic innervation. leucylproline 47-49 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 Rattus norvegicus 129-133 31128687-4 2019 The LP-induced maize root morphological adaption was dependent on changes in the expression of related genes, like IPS1, pht1;1 LPR1b, KRPs, and EXPB1-4. leucylproline 4-6 phosphate transporter protein 1 Zea mays 121-125 31128687-4 2019 The LP-induced maize root morphological adaption was dependent on changes in the expression of related genes, like IPS1, pht1;1 LPR1b, KRPs, and EXPB1-4. leucylproline 4-6 expansin-B1 Zea mays 145-152 31128687-6 2019 The upregulation of the GA synthesis genes AN1, GA20ox1, and GA20ox2 and the downregulation of the GA inactive genes GA2ox1 and GA2ox2 were observed in maize roots subjected to LP stress, and the increased GA biosynthesis and signaling were involved in root growth. leucylproline 177-179 ent-copalyl diphosphate synthase AN1, chloroplastic Zea mays 43-46 30952698-2 2019 Mannan-binding lectin-associated serine proteinase 2 (MASP-2) is essential for LP activation, and therefore, it is a potential drug target. leucylproline 79-81 MBL associated serine protease 2 Homo sapiens 0-52 30952698-2 2019 Mannan-binding lectin-associated serine proteinase 2 (MASP-2) is essential for LP activation, and therefore, it is a potential drug target. leucylproline 79-81 MBL associated serine protease 2 Homo sapiens 54-60 30794571-8 2019 At 14 km h-1, the oxygen uptake was 3.0% lower (P = 0.05) and GE was 3.8% higher (P = 0.03) with LP than with SSP. leucylproline 97-99 H1.5 linker histone, cluster member Homo sapiens 9-12 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 tumor necrosis factor Rattus norvegicus 134-143 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 S100 calcium binding protein B Rattus norvegicus 188-194 30459599-8 2018 The compounds including Taurine, Paeonol, and Ginsenoside Rb1 in LP can activate PI3K/AKT pathway. leucylproline 65-67 AKT serine/threonine kinase 1 Rattus norvegicus 86-89 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 enolase 2 Rattus norvegicus 196-219 30459599-7 2018 Second, we found that LP can not only decreased the level of high sensitive C reactive protein (HS-CRP), tumor necrosis factor-alpha (TNF-alpha), NF-kbeta, D-dimmer (D2D), estradiol (E2), S-100B, neuron specific enolase (NSE), and interleukin 1 (IL-1) in plasma on spontaneously hypertensive rats (SHRs), but also promoted cell proliferation and inhibited cell apoptosis on the glutamate-induced PC12 cell. leucylproline 22-24 enolase 2 Rattus norvegicus 221-224 30459599-11 2018 Overall, our results suggested that LP had integrated therapeutic effect on ICH due to activities of anti-inflammatory, anti-coagulation, blood vessel protection, and protection neuron from excitotoxicity based on the way of "multi-component, multi-target, multi-pathway," and compound combination in LP can offer protection neuron from excitotoxicity at the low concentration by activation of the PI3K/Akt signal pathway. leucylproline 36-38 AKT serine/threonine kinase 1 Rattus norvegicus 403-406 30226140-8 2018 Median CD4 count among LP was 134 cells/muL (interquartile range 72.25-219). leucylproline 23-25 CD4 molecule Homo sapiens 7-10 30003075-11 2018 The recent discovery of the feedback loop, wherein the LP-evoked release of active MMP-2 triggers the receptor cleavage, provided one explanation. leucylproline 55-57 matrix metallopeptidase 2 Homo sapiens 83-88 30178063-9 2018 On the basis of an LP value of 0.2 or greater, the sensitivity for a diagnosis of BPPV was 0.75 and the specificity was 1.0. leucylproline 19-21 benign paroxysmal positional vertigo Homo sapiens 82-86 30178063-11 2018 Patients with BPPV had a statistically significantly different LP value (odds ratio, 5.92; 95% CI, 2.73-12.83) than did patients without BPPV. leucylproline 63-65 benign paroxysmal positional vertigo Homo sapiens 14-18 29900811-7 2018 Moreover, altered protein (11beta-HSD2, GR, MR and type 1 CRH receptors) expressions may underlie the increase in anxiety-like behavior in LP offspring. leucylproline 139-141 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 27-38 29900811-7 2018 Moreover, altered protein (11beta-HSD2, GR, MR and type 1 CRH receptors) expressions may underlie the increase in anxiety-like behavior in LP offspring. leucylproline 139-141 glutathione-disulfide reductase Rattus norvegicus 40-42 29930715-4 2018 Mechanistic dissection demonstrated that LP enhanced androgen receptor degradation, which resulted in an upregulation of MHC class I polypeptide-related sequence A (MICA) and MICB. leucylproline 41-43 MHC class I polypeptide-related sequence A Homo sapiens 121-163 29930715-4 2018 Mechanistic dissection demonstrated that LP enhanced androgen receptor degradation, which resulted in an upregulation of MHC class I polypeptide-related sequence A (MICA) and MICB. leucylproline 41-43 MHC class I polypeptide-related sequence A Homo sapiens 165-169 29930715-4 2018 Mechanistic dissection demonstrated that LP enhanced androgen receptor degradation, which resulted in an upregulation of MHC class I polypeptide-related sequence A (MICA) and MICB. leucylproline 41-43 MHC class I polypeptide-related sequence B Homo sapiens 175-179 29930715-5 2018 In turn, the induced expression of MICA and MICB was able to further trigger NK cell activation, forming a positive loop between NK cells and PCa cells in the presence of LP solution. leucylproline 171-173 MHC class I polypeptide-related sequence A Homo sapiens 35-39 29930715-5 2018 In turn, the induced expression of MICA and MICB was able to further trigger NK cell activation, forming a positive loop between NK cells and PCa cells in the presence of LP solution. leucylproline 171-173 MHC class I polypeptide-related sequence B Homo sapiens 44-48 30003075-12 2018 Another mechanism might be that of cancer cells expressing a structurally altered P2RX7 receptor, devoid of the LP function. leucylproline 112-114 purinergic receptor P2X 7 Homo sapiens 82-87 29997613-3 2018 As we had previously shown, plasma-derived MBL (pdMBL) contains pre-activated MASPs that upon in vivo pdMBL substitution results in restoration of MBL concentrations but no LP functionality due to immediate inactivation of pdMBL-MASP complexes upon infusion. leucylproline 173-175 mannose binding lectin 2 Homo sapiens 43-46 29997613-4 2018 In this study, we analyzed MBL-sufficient and -deficient serum by size-exclusion chromatography for complexes of LP activation. leucylproline 113-115 mannose binding lectin 2 Homo sapiens 27-30 29412487-6 2018 RESULTS: The qPCR results demonstrated that IL-9 and MMP9 mRNA levels were positively correlated in OLP lesions, and both significantly elevated in EP and LP lesions of erosive type OLP. leucylproline 101-103 interleukin 9 Homo sapiens 44-48 28992079-3 2018 We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent receptor cleavage. leucylproline 161-163 purinergic receptor P2X 7 Homo sapiens 65-69 28992079-3 2018 We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent receptor cleavage. leucylproline 161-163 matrix metallopeptidase 2 Homo sapiens 97-123 28992079-3 2018 We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent receptor cleavage. leucylproline 161-163 matrix metallopeptidase 2 Homo sapiens 125-130 28992079-3 2018 We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent receptor cleavage. leucylproline 161-163 matrix metallopeptidase 2 Homo sapiens 182-187 29892304-4 2018 Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP. leucylproline 187-189 mannose-binding lectin (protein C) 2 Mus musculus 24-27 29892304-4 2018 Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP. leucylproline 187-189 mannose-binding lectin (protein C) 2 Mus musculus 131-134 29892304-5 2018 MASP-1 encoded by the Masp1 gene significantly contributes to the activation of the LP. leucylproline 84-86 mannan-binding lectin serine peptidase 1 Mus musculus 0-6 29892304-5 2018 MASP-1 encoded by the Masp1 gene significantly contributes to the activation of the LP. leucylproline 84-86 mannan-binding lectin serine peptidase 1 Mus musculus 22-27 29892304-11 2018 Our data indicate that MASP-1/3 plays essential roles in the development of lupus-like glomerulonephritis in MRL/lpr mice, most likely via activation of the LP and/or AP. leucylproline 157-159 mannan-binding lectin serine peptidase 1 Mus musculus 23-31 29892304-11 2018 Our data indicate that MASP-1/3 plays essential roles in the development of lupus-like glomerulonephritis in MRL/lpr mice, most likely via activation of the LP and/or AP. leucylproline 157-159 Fas (TNF receptor superfamily member 6) Mus musculus 113-116 29439142-10 2018 Finally, the expression of lysosomal protease cathepsin genes, CTSB and cathepsin D (CTSD), were significantly up-regulated in sheep ovaries in the HP group compared with the LP group (P<0.05). leucylproline 175-177 cathepsin B Ovis aries 63-67 29439142-10 2018 Finally, the expression of lysosomal protease cathepsin genes, CTSB and cathepsin D (CTSD), were significantly up-regulated in sheep ovaries in the HP group compared with the LP group (P<0.05). leucylproline 175-177 cathepsin D Ovis aries 85-89 29475986-3 2018 Mannose-lectin binding-associated serine protease (MASP)-1 is known to be the initiator protease of the LP. leucylproline 104-106 MBL associated serine protease 1 Homo sapiens 0-58 29475986-4 2018 Using a specific and potent inhibitor of MASP-1, SGMI-1, as well as other MASP-1 inhibitors with different mechanisms of action, we demonstrated that, in addition to its functions in the LP, MASP-1 is essential for bacterial LPS-induced AP activation, whereas it has little effect on zymosan-induced AP activation. leucylproline 187-189 MBL associated serine protease 1 Homo sapiens 41-47 29412487-6 2018 RESULTS: The qPCR results demonstrated that IL-9 and MMP9 mRNA levels were positively correlated in OLP lesions, and both significantly elevated in EP and LP lesions of erosive type OLP. leucylproline 101-103 matrix metallopeptidase 9 Homo sapiens 53-57 29078731-5 2018 In LLC-bearing mice, LP showed a synergic antitumor effect with CTX, whereas LP alone did not present direct antitumor activity. leucylproline 21-23 V-set and immunoglobulin domain containing 2 Mus musculus 64-67 29274626-3 2018 The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1beta, IL-15, TNF-alpha and MIP-1alpha, through the NF-kappaB pathway. leucylproline 24-26 interleukin 1 beta Homo sapiens 129-137 29274626-3 2018 The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1beta, IL-15, TNF-alpha and MIP-1alpha, through the NF-kappaB pathway. leucylproline 24-26 interleukin 15 Homo sapiens 139-144 29274626-3 2018 The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1beta, IL-15, TNF-alpha and MIP-1alpha, through the NF-kappaB pathway. leucylproline 24-26 tumor necrosis factor Homo sapiens 146-155 29274626-3 2018 The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1beta, IL-15, TNF-alpha and MIP-1alpha, through the NF-kappaB pathway. leucylproline 24-26 C-C motif chemokine ligand 3 Homo sapiens 160-170 29284147-4 2018 In regards to the enzyme activities, LP supplementation significantly imporved the enzyme activities of alkaline phosphatase (AKP) (P < .05), acid phosphatase (ACP) and superoxide dismutase (SOD), ES supplementation significantly imporved AKP activity (P < .05), and WC supplementation significantly imporved ACP activity (P < .05). leucylproline 37-39 superoxide dismutase [Mn], mitochondrial Cucumis sativus 172-192 29284147-4 2018 In regards to the enzyme activities, LP supplementation significantly imporved the enzyme activities of alkaline phosphatase (AKP) (P < .05), acid phosphatase (ACP) and superoxide dismutase (SOD), ES supplementation significantly imporved AKP activity (P < .05), and WC supplementation significantly imporved ACP activity (P < .05). leucylproline 37-39 superoxide dismutase [Mn], mitochondrial Cucumis sativus 194-197 29078731-6 2018 Further, LP was found to enhance immune organ indexes, splenocyte number, and T lymphocyte subsets in normal mice and LLC-bearing mice treated with CTX. leucylproline 9-11 V-set and immunoglobulin domain containing 2 Mus musculus 148-151 29078731-7 2018 The decline of white blood cell and platelet counts, splenocyte proliferation activity, and peritoneal macrophage phagocytic function caused by CTX were also significantly suppressed by LP treatment in LLC-bearing mice. leucylproline 186-188 V-set and immunoglobulin domain containing 2 Mus musculus 144-147 29078731-8 2018 Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein alpha/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. leucylproline 9-11 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 104-108 29078731-8 2018 Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein alpha/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. leucylproline 9-11 signal-regulatory protein alpha Mus musculus 109-140 29078731-8 2018 Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein alpha/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. leucylproline 9-11 Rous sarcoma oncogene Mus musculus 141-144 29078731-8 2018 Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein alpha/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. leucylproline 9-11 V-set and immunoglobulin domain containing 2 Mus musculus 221-224 29128221-6 2018 Because OPN is involved in involution, it might also have an effect on LP. leucylproline 71-73 secreted phosphoprotein 1 Bos taurus 8-11 29128221-7 2018 The objective of the present study was to evaluate whether LP could be influenced by genetic variations in the SPP1 gene. leucylproline 59-61 secreted phosphoprotein 1 Bos taurus 111-115 29128221-18 2018 From a genetic perspective, data from the present study suggest OPN as a candidate gene associated with LP for dairy cows. leucylproline 104-106 secreted phosphoprotein 1 Bos taurus 64-67 28693108-4 2017 NO3- concentrations in the fresh-blast waste rock and recently placed waste rock used for the HC and LP experiments were highly variable, ranging from below detection to 241mg/kg. leucylproline 101-103 NBL1, DAN family BMP antagonist Homo sapiens 0-3 29197742-6 2018 Ex-vivo experiments confirmed a direct dose-dependent inhibitory effect of ASNase on the LP functionality. leucylproline 89-91 asparaginase Homo sapiens 75-81 28883047-10 2017 Moreover, LP-SED rats displayed higher levels of Drd2 in the CPu compared with the other SED groups, and this higher expression was decreased by physical training. leucylproline 10-12 dopamine receptor D2 Rattus norvegicus 49-53 29089377-5 2017 It controls LP stability/growth via a Rac-dependent pathway, likely by modulating microtubule networks while also regulating F-actin remodeling at the cell rear to promote somal translocation via a previously unrecognized myosin phosphatase-RhoA-interacting protein-dependent pathway. leucylproline 12-14 ras homolog family member A Mus musculus 241-245 29083540-2 2017 In this study, surfaces are modified with a LAIR-1 ligand peptide (LP), and it is observed that macrophages cultured on LAIR-1 LP-conjugated surfaces exhibit significantly reduced secretion of inflammatory cytokines in response to proinflammatory stimuli that reflect an injured environment. leucylproline 67-69 leukocyte associated immunoglobulin like receptor 1 Homo sapiens 44-50 29083540-2 2017 In this study, surfaces are modified with a LAIR-1 ligand peptide (LP), and it is observed that macrophages cultured on LAIR-1 LP-conjugated surfaces exhibit significantly reduced secretion of inflammatory cytokines in response to proinflammatory stimuli that reflect an injured environment. leucylproline 67-69 leukocyte associated immunoglobulin like receptor 1 Homo sapiens 120-126 28883047-11 2017 Physical training also decreased Dat and increased Gdnf in the CPu of LP rats. leucylproline 70-72 glial cell derived neurotrophic factor Rattus norvegicus 51-55 29117457-2 2017 The present study aimed to determine the relationship between long-photoperiod (LP) and diurnal TSHbeta gene expression in the juvenile chicken by comparing LP-photostimulated birds with groups kept on a short photoperiod (SP) for 1 or 12 days. leucylproline 80-82 thyroid stimulating hormone beta Gallus gallus 96-103 29117457-3 2017 TSHbeta expression increased by 3- and 23-fold after 1 and 12 days of LP-photostimulation both during the day and at night. leucylproline 70-72 thyroid stimulating hormone beta Gallus gallus 0-7 29117457-4 2017 Under both SP and LP conditions, TSHbeta expression was between 3- and 14-fold higher at night than in the day, suggesting that TSHbeta expression cycles in a diurnal pattern irrespective of photoperiod. leucylproline 18-20 thyroid stimulating hormone beta Gallus gallus 33-40 29117457-4 2017 Under both SP and LP conditions, TSHbeta expression was between 3- and 14-fold higher at night than in the day, suggesting that TSHbeta expression cycles in a diurnal pattern irrespective of photoperiod. leucylproline 18-20 thyroid stimulating hormone beta Gallus gallus 128-135 28038705-6 2017 In 4 cases, at least 20% of LP cells were positive for CD20/cyclin D1. leucylproline 28-30 keratin 20 Homo sapiens 55-59 28188176-3 2017 Whereas in the absence of C4, CP can no longer activate C3, LP retains a residual but physiologically critical capacity to convert native C3 into its activation fragments, C3a and C3b. leucylproline 60-62 complement C3 Homo sapiens 172-175 28751968-11 2017 In 17 (15.8%) cases the proximal end of the LP shunt was placed at L1/L2 level or above. leucylproline 44-46 L1 cell adhesion molecule Homo sapiens 67-72 28399169-11 2017 Moreover, the cell-to-cell movement of ZCN14 through plasmodesmata is likely blocked under a 16-h-light LP. leucylproline 104-106 ZCN14 protein Zea mays 39-44 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 mannosidase alpha class 1C member 1 Bos taurus 29-35 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 mitogen-activated protein kinase kinase kinase 5 Bos taurus 37-43 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 hyperpolarization activated cyclic nucleotide gated potassium channel 1 Bos taurus 45-49 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 tetraspanin 9 Bos taurus 51-57 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 mitochondrial ribosomal protein S30 Bos taurus 59-65 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 testis expressed 14, intercellular bridge forming factor Bos taurus 67-72 28088409-8 2017 Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions. leucylproline 118-120 C-C motif chemokine ligand 28 Bos taurus 78-83 28088409-10 2017 Upstream regulators relevant for LP positional candidate genes were prolactin (PRL), peroxisome proliferator-activated receptor gamma (PPARG), and Erb-B2 receptor tyrosine kinase 2 (ERBB2). leucylproline 33-35 peroxisome proliferator activated receptor gamma Bos taurus 85-133 28088409-10 2017 Upstream regulators relevant for LP positional candidate genes were prolactin (PRL), peroxisome proliferator-activated receptor gamma (PPARG), and Erb-B2 receptor tyrosine kinase 2 (ERBB2). leucylproline 33-35 peroxisome proliferator activated receptor gamma Bos taurus 135-140 28088409-10 2017 Upstream regulators relevant for LP positional candidate genes were prolactin (PRL), peroxisome proliferator-activated receptor gamma (PPARG), and Erb-B2 receptor tyrosine kinase 2 (ERBB2). leucylproline 33-35 erb-b2 receptor tyrosine kinase 2 Bos taurus 147-180 28088409-10 2017 Upstream regulators relevant for LP positional candidate genes were prolactin (PRL), peroxisome proliferator-activated receptor gamma (PPARG), and Erb-B2 receptor tyrosine kinase 2 (ERBB2). leucylproline 33-35 erb-b2 receptor tyrosine kinase 2 Bos taurus 182-187 28209189-1 2017 BACKGROUND: Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. leucylproline 31-33 CD4 molecule Homo sapiens 114-117 28209189-1 2017 BACKGROUND: Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. leucylproline 31-33 CD4 molecule Homo sapiens 137-140 29073268-11 2017 However, escape from silencing is induced rapidly by infection with UVPRV or LP in a PKA- and JNK-independent manner. leucylproline 77-79 mitogen-activated protein kinase 8 Homo sapiens 94-97 28973705-3 2017 METHODS: Among individuals with multigene panel testing (inclusive of the TP53 gene) who were part of either the Inherited Cancer Registry or the Vanderbilt Hereditary Cancer Registry protocols and were confirmed to have a P/LP variant in TP53, pedigree was reviewed to characterize personal and family history, including original clinical context for genetic testing and whether they met clinical diagnostic criteria for TP53. leucylproline 225-227 tumor protein p53 Homo sapiens 239-243 28973705-3 2017 METHODS: Among individuals with multigene panel testing (inclusive of the TP53 gene) who were part of either the Inherited Cancer Registry or the Vanderbilt Hereditary Cancer Registry protocols and were confirmed to have a P/LP variant in TP53, pedigree was reviewed to characterize personal and family history, including original clinical context for genetic testing and whether they met clinical diagnostic criteria for TP53. leucylproline 225-227 tumor protein p53 Homo sapiens 239-243 28257428-5 2017 The results showed that serum concentrations and mRNA levels of IGF-1 in the liver were higher in the CP group than in the LP group. leucylproline 123-125 insulin like growth factor 1 Homo sapiens 64-69 28369625-2 2017 Plasma membrane H+-ATPase (PM H+-ATPase) plays an important role in the plant response to low-phosphorus stress (LP). leucylproline 113-115 plasma membrane H+-ATPase Arabidopsis thaliana 0-25 28369625-10 2017 The modulation of H+ efflux by AHA2 or AHA7 was affected by the action of 14-3-3 proteins and/or auxin regulatory pathways in the context of root growth and response to LP. leucylproline 169-171 H[+]-ATPase 2 Arabidopsis thaliana 31-35 28369625-10 2017 The modulation of H+ efflux by AHA2 or AHA7 was affected by the action of 14-3-3 proteins and/or auxin regulatory pathways in the context of root growth and response to LP. leucylproline 169-171 H[+]-ATPase 7 Arabidopsis thaliana 39-43 28369625-11 2017 Our results suggest that under LP conditions, AHA2 acts mainly to modulate primary root elongation by mediating H+ efflux in the root elongation zone, whereas AHA7 plays an important role in root hair formation by mediating H+ efflux in the root hair zone. leucylproline 31-33 H[+]-ATPase 2 Arabidopsis thaliana 46-50 28038705-6 2017 In 4 cases, at least 20% of LP cells were positive for CD20/cyclin D1. leucylproline 28-30 cyclin D1 Homo sapiens 60-69 27327245-6 2017 Similarly, the frequencies of macrophages, neutrophils, natural killer (NK), and NKT cells in the PPs and LP of mice with colitis declined after FAAH blockade, as did concentrations of systemic and colon inflammatory cytokines. leucylproline 106-108 fatty acid amide hydrolase Mus musculus 145-149 27998726-3 2017 Nineteen of 26 lymph nodes involved by NLPHL demonstrated a population with an LP immunophenotype (73%), which included expression of germinal center markers (CD75/Bcl-6-positive, CD32-weak/negative without CD10), a B-cell immunophenotype (CD19/CD20/CD40+), IgD and/or IgM expression (67%), and lack of programmed death-ligand 1/ligand 2. leucylproline 40-42 Fc gamma receptor IIa Homo sapiens 180-184 27910140-10 2017 The rise in MPO activity and pro-inflammatory cytokines, over-contractility of the smooth muscle, and diarrhea were all abrogated in LP-treated mice. leucylproline 133-135 myeloperoxidase Mus musculus 12-15 27840060-10 2017 None of these effects were evident in blank LP-exposed cells and non-LP MPA formulation reduced only IL-6 production. leucylproline 69-71 interleukin 6 Homo sapiens 101-105 27577176-7 2017 Assuming a dominance model for the lactase persistence (LP) minor T-allele, linear regression models showed statistically significant associations between the LP genotype CT/TT and BMI, fat mass and weight (beta=1.114, P=0.003; beta=1.309, P=0.007 and beta=2.67, P=0.021, respectively) after adjustment for age and sex. leucylproline 56-58 lactase Homo sapiens 35-42 27882174-3 2016 The results of the present study found that the mRNA and protein levels of cyclooxygenase-2 (COX2) were higher in LP tissues than in normal laryngeal samples, and prostaglandin E2 (PGE2) production was increased in LP cells, as determined by quantitative polymerase chain reaction, western blot and radioimmunoassay analyses. leucylproline 114-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-91 28006027-6 2016 Exposure to long photoperiod (LP) induced a larger distribution of peak times of the single-cell PER2::LUC rhythms in the anterior SCN, compared to short photoperiod. leucylproline 30-32 period circadian regulator 2 Homo sapiens 97-101 28006027-7 2016 Interestingly, the cycle-to-cycle variability in single-cell period of PER2::LUC rhythms is also higher in the anterior SCN in LP, and is positively correlated with peak time dispersal. leucylproline 127-129 period circadian regulator 2 Homo sapiens 71-75 27541079-5 2016 RESULTS: Salivary concentrations of IL-17A and IL-23 were elevated significantly in patients with LP compared with controls and patients with GP. leucylproline 98-100 interleukin 17A Homo sapiens 36-42 27541079-5 2016 RESULTS: Salivary concentrations of IL-17A and IL-23 were elevated significantly in patients with LP compared with controls and patients with GP. leucylproline 98-100 interleukin 23 subunit alpha Homo sapiens 47-52 27541079-6 2016 Salivary IL-1beta concentrations were significantly higher in patients with GP than in patients with LP, whereas no difference was found between LP and control groups. leucylproline 101-103 interleukin 1 beta Homo sapiens 9-17 27541079-9 2016 CONCLUSION: Elevated salivary IL-1beta concentrations are related to GP, whereas distinct elevation and reduction profiles of IL-17A and IL-23 are detected in saliva of patients with LP and GP. leucylproline 183-185 interleukin 17A Homo sapiens 126-132 27541079-9 2016 CONCLUSION: Elevated salivary IL-1beta concentrations are related to GP, whereas distinct elevation and reduction profiles of IL-17A and IL-23 are detected in saliva of patients with LP and GP. leucylproline 183-185 interleukin 23 subunit alpha Homo sapiens 137-142 27882174-3 2016 The results of the present study found that the mRNA and protein levels of cyclooxygenase-2 (COX2) were higher in LP tissues than in normal laryngeal samples, and prostaglandin E2 (PGE2) production was increased in LP cells, as determined by quantitative polymerase chain reaction, western blot and radioimmunoassay analyses. leucylproline 114-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 93-97 27882174-4 2016 Notably, the increase in COX2 and PGE2 levels was significantly abrogated in the ISO-treated LP cells. leucylproline 93-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 25-29 27882174-6 2016 By inhibiting the COX2 activity of LP cells, ISO treatment markedly suppressed cell viability and proliferation, as determined using Cell Counting Kit-8, flow cytometry and 5-ethynyl-20-deoxyuridine incorporation assays. leucylproline 35-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-22 27882174-8 2016 Collectively, the present results suggest that COX2 is critical in the progression of LP, and ISO is a potential agent for LP therapy by impeding p38 MAPK/COX2 signaling. leucylproline 86-88 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-51 27882174-8 2016 Collectively, the present results suggest that COX2 is critical in the progression of LP, and ISO is a potential agent for LP therapy by impeding p38 MAPK/COX2 signaling. leucylproline 123-125 prostaglandin-endoperoxide synthase 2 Homo sapiens 155-159 26874675-3 2016 C1-esterase inhibitor (C1-INH) controls activation of the classical pathway (CP) and the lectin pathway (LP). leucylproline 105-107 complement C1s Homo sapiens 0-11 27369070-14 2016 CONCLUSIONS: The CD4+ SMPTCL/CD8+ LP subgroup usually presents with solitary lesions and demonstrates an indolent clinical course. leucylproline 34-36 CD4 molecule Homo sapiens 17-20 27369070-14 2016 CONCLUSIONS: The CD4+ SMPTCL/CD8+ LP subgroup usually presents with solitary lesions and demonstrates an indolent clinical course. leucylproline 34-36 CD8a molecule Homo sapiens 29-32 27534790-9 2016 On the other hand, LP continued to be the major problem in EGFR wild-type patients. leucylproline 19-21 epidermal growth factor receptor Homo sapiens 59-63 27577570-2 2016 This work defines the contributions of each of the three LP-associated enzymes-mannan-binding lectin-associated serine protease (MASP)-1, MASP-2, and MASP-3-to ischemic brain injury in experimental mouse models of stroke. leucylproline 57-59 mannan-binding lectin serine peptidase 2 Mus musculus 138-144 27131433-11 2016 Furthermore, the total extracts of LG, LP and HP exhibited non-selective inhibitions against the activity of the cyclooxygenases COX-1 and COX-2. leucylproline 39-41 cytochrome c oxidase I, mitochondrial Mus musculus 129-134 27131433-11 2016 Furthermore, the total extracts of LG, LP and HP exhibited non-selective inhibitions against the activity of the cyclooxygenases COX-1 and COX-2. leucylproline 39-41 cytochrome c oxidase II, mitochondrial Mus musculus 139-144 27374831-5 2016 When the LP shunt was in place, the total CSF volume was smaller than when the VP shunt was in place (222.4 cm(3) vs 279.2 cm(3)). leucylproline 9-11 colony stimulating factor 2 Homo sapiens 42-45 27374831-6 2016 The difference was almost completely the result of the spinal CSF volume reduction (49.3 cm(3) and 104.9 cm(3) for LP and VP, respectively), while the cranial CSF volume was not considerably altered (173.2 cm(3) and 174.2 cm(3) for LP and VP, respectively). leucylproline 115-117 colony stimulating factor 2 Homo sapiens 62-65 26874675-3 2016 C1-esterase inhibitor (C1-INH) controls activation of the classical pathway (CP) and the lectin pathway (LP). leucylproline 105-107 serpin family G member 1 Homo sapiens 23-29 26874675-6 2016 The current study investigates the effects of C1-INH in the presence or absence of different clinically used heparinoids on the CP, LP and AP. leucylproline 132-134 serpin family G member 1 Homo sapiens 46-52 26874675-12 2016 Next to their individual effects on complement activation, heparinoids also enhanced the inhibitory capacity of C1-INH significantly on the CP and LP. leucylproline 147-149 serpin family G member 1 Homo sapiens 112-118 27048414-2 2016 Surface-adsorbed salivary agglutinin (SAG) activates the lectin pathway (LP) of the complement system via mannose-binding lectin, while SAG in solution inhibits complement activation. leucylproline 73-75 deleted in malignant brain tumors 1 Homo sapiens 17-36 26795763-3 2016 Mannan-binding lectin (MBL) is a collectin member of the LP PRMs. leucylproline 57-59 mannose binding lectin 2 Homo sapiens 0-21 26795763-3 2016 Mannan-binding lectin (MBL) is a collectin member of the LP PRMs. leucylproline 57-59 mannose binding lectin 2 Homo sapiens 23-26 26795763-6 2016 We hypothesized that variants FCN2 + 6424 and FCN3 + 1637delC that cause gene-dose-dependent reduction in ficolin-2 and ficolin-3 levels, respectively, may be rare in MBL-deficient individuals due to the importance of compensation within the LP. leucylproline 242-244 ficolin 2 Homo sapiens 30-34 26795763-6 2016 We hypothesized that variants FCN2 + 6424 and FCN3 + 1637delC that cause gene-dose-dependent reduction in ficolin-2 and ficolin-3 levels, respectively, may be rare in MBL-deficient individuals due to the importance of compensation within the LP. leucylproline 242-244 ficolin 3 Homo sapiens 46-50 26795763-6 2016 We hypothesized that variants FCN2 + 6424 and FCN3 + 1637delC that cause gene-dose-dependent reduction in ficolin-2 and ficolin-3 levels, respectively, may be rare in MBL-deficient individuals due to the importance of compensation within the LP. leucylproline 242-244 ficolin 2 Homo sapiens 106-115 26795763-6 2016 We hypothesized that variants FCN2 + 6424 and FCN3 + 1637delC that cause gene-dose-dependent reduction in ficolin-2 and ficolin-3 levels, respectively, may be rare in MBL-deficient individuals due to the importance of compensation within the LP. leucylproline 242-244 ficolin 3 Homo sapiens 120-129 27048414-2 2016 Surface-adsorbed salivary agglutinin (SAG) activates the lectin pathway (LP) of the complement system via mannose-binding lectin, while SAG in solution inhibits complement activation. leucylproline 73-75 deleted in malignant brain tumors 1 Homo sapiens 38-41 27048414-12 2016 In solution, saliva inhibits the LP, depending on the presence of SAG, but independent of the secretor status. leucylproline 33-35 deleted in malignant brain tumors 1 Homo sapiens 66-69 25568343-2 2015 Here we extend these studies via pharmacological inhibition of the Arp2/3 complex in sea urchin coelomocytes, cells that possess an unusually broad LP region and display correspondingly exaggerated centripetal flow. leucylproline 148-150 Actin-related protein 2 Drosophila melanogaster 67-71 26920789-3 2016 LP is defined as being diagnosed when CD4 < 350 cells/ml or AIDS. leucylproline 0-2 CD4 molecule Homo sapiens 38-41 27136025-5 2016 Results showed that pens of steers fed LP had increased ADG (live and carcass adjusted), DMI, and HCW compared with those fed monensin ( < 0.05). leucylproline 39-41 ADG Bos taurus 56-59 26866273-10 2016 In LP MSCs treated with t-BHQ for ~7 days, the phosphorylation and nuclear localization of NRF2 improved and SIRT1 protein level increased, whereas p53 protein levels decreased. leucylproline 3-5 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 26866273-10 2016 In LP MSCs treated with t-BHQ for ~7 days, the phosphorylation and nuclear localization of NRF2 improved and SIRT1 protein level increased, whereas p53 protein levels decreased. leucylproline 3-5 sirtuin 1 Homo sapiens 109-114 26866273-10 2016 In LP MSCs treated with t-BHQ for ~7 days, the phosphorylation and nuclear localization of NRF2 improved and SIRT1 protein level increased, whereas p53 protein levels decreased. leucylproline 3-5 tumor protein p53 Homo sapiens 148-151 27143987-4 2016 Tissue inhibitor of metalloprotease- (TIMP-) 1 expression was upregulated while that of matrix metalloproteinase- (MMP-) 1 was downregulated in skin tissue of LP-treated as compared to untreated aging mice. leucylproline 159-161 tissue inhibitor of metalloproteinase 1 Mus musculus 0-46 27143987-4 2016 Tissue inhibitor of metalloprotease- (TIMP-) 1 expression was upregulated while that of matrix metalloproteinase- (MMP-) 1 was downregulated in skin tissue of LP-treated as compared to untreated aging mice. leucylproline 159-161 matrix metallopeptidase 13 Mus musculus 88-122 27143987-5 2016 Additionally, phosphorylation of c-Jun N-terminal kinase (JNK) and p38 was higher in aging skin than in young skin, while LP treatment suppressed phospho-JNK expression. leucylproline 122-124 mitogen-activated protein kinase 8 Mus musculus 154-157 27143987-6 2016 LP application also enhanced the expression of antioxidative enzymes in skin tissue, causing a decrease in malondialdehyde levels and increases in superoxide dismutase, catalase, and glutathione peroxidase levels relative to those in untreated aging mice. leucylproline 0-2 catalase Mus musculus 169-177 27143987-7 2016 These results indicate that LP inhibits MMP-1 expression by preventing oxidative stress and JNK phosphorylation, thereby delaying skin collagen breakdown during aging. leucylproline 28-30 matrix metallopeptidase 13 Mus musculus 40-45 27143987-7 2016 These results indicate that LP inhibits MMP-1 expression by preventing oxidative stress and JNK phosphorylation, thereby delaying skin collagen breakdown during aging. leucylproline 28-30 mitogen-activated protein kinase 8 Mus musculus 92-95 26148903-6 2015 Our data indicate that SLE patient-derived anti-C1q can activate the CP and the LP but not the alternative pathway of complement. leucylproline 80-82 complement C1q A chain Homo sapiens 43-51 26390973-6 2015 We demonstrate that LP are the most potent non-LPS pro-inflammatory toxins of the bacterial cell walls, signalling via Toll-like receptor-2, not only in vitro, but also when inoculated into mice: A synthetic LP caused sepsis-related pathological symptoms in a dose-response manner. leucylproline 20-22 toll-like receptor 2 Mus musculus 119-139 26390973-6 2015 We demonstrate that LP are the most potent non-LPS pro-inflammatory toxins of the bacterial cell walls, signalling via Toll-like receptor-2, not only in vitro, but also when inoculated into mice: A synthetic LP caused sepsis-related pathological symptoms in a dose-response manner. leucylproline 47-49 toll-like receptor 2 Mus musculus 119-139 26041677-10 2015 The postintervention serum iron response was lower (P < 0.0001) in the LP group than in the HP group after controlling for the baseline serum iron response and hepcidin concentration, reflecting in a 64% lower AUC. leucylproline 74-76 hepcidin antimicrobial peptide Homo sapiens 163-171 26427117-8 2015 The expression of VEGF, ERK and Cyclin D1 were inhibited in the LP and JP groups (P < 0.05), and cell differentiation was increased. leucylproline 64-66 vascular endothelial growth factor A Mus musculus 18-22 26427117-8 2015 The expression of VEGF, ERK and Cyclin D1 were inhibited in the LP and JP groups (P < 0.05), and cell differentiation was increased. leucylproline 64-66 mitogen-activated protein kinase 1 Mus musculus 24-27 26427117-8 2015 The expression of VEGF, ERK and Cyclin D1 were inhibited in the LP and JP groups (P < 0.05), and cell differentiation was increased. leucylproline 64-66 cyclin D1 Mus musculus 32-41 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 17-19 vascular endothelial growth factor A Mus musculus 190-194 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 17-19 mitogen-activated protein kinase 1 Mus musculus 196-199 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 17-19 cyclin D1 Mus musculus 204-213 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 107-109 vascular endothelial growth factor A Mus musculus 190-194 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 107-109 mitogen-activated protein kinase 1 Mus musculus 196-199 26427117-10 2015 CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1. leucylproline 107-109 cyclin D1 Mus musculus 204-213 25956056-8 2015 The LP based method outperforms the baseline with the accuracies: 4.44% Acc1, 24.44% Acc10, and 62.22% Acc100, where AccN means the top N accuracy. leucylproline 4-6 acetyl-CoA carboxylase alpha Homo sapiens 72-76 25956056-8 2015 The LP based method outperforms the baseline with the accuracies: 4.44% Acc1, 24.44% Acc10, and 62.22% Acc100, where AccN means the top N accuracy. leucylproline 4-6 acid sensing ion channel subunit 2 Homo sapiens 117-121 25884148-2 2015 LP was defined as <350 CD4 cells/microL or AIDS. leucylproline 0-2 CD4 molecule Homo sapiens 26-29 26002258-13 2015 Thrombin generation assays revealed that the total, lag time to, and peak thrombin formation were higher in SDP and SD-SDP compared with FFP and LP. leucylproline 145-147 coagulation factor II, thrombin Homo sapiens 0-8 25811653-11 2015 Thus, LP-induced OHT results in retrograde degeneration of RGCs and m+RGCs, as well as in the loss of CTB-labelled retinotectal terminals. leucylproline 6-8 chitobiase Mus musculus 102-105 25576772-9 2015 In conclusion, LP induces in the GCL selective RGCs loss that does not progress after 1 month, and S- and L-cone loss that progresses for up to 6 months. leucylproline 15-17 germ cell-less 1, spermatogenesis associated Rattus norvegicus 33-36 25568343-3 2015 Using light and electron microscopy, we demonstrate that Arp2/3 complex inhibition via the drug CK666 dramatically altered LP actin architecture, slowed centripetal flow, drove a lamellipodial-to-filopodial shape change in suspended cells, and induced a novel actin structural organization during cell spreading. leucylproline 123-125 Actin-related protein 2 Drosophila melanogaster 57-61 25108293-4 2015 LP shunting was evaluated with the modified Rankin Scale, the Japan Normal-Pressure Hydrocephalus Grading Scale, the Mini-Mental State Examination, the Frontal Assessment Battery, and the Trail-Making Test A as outcome measures. leucylproline 0-2 TNF superfamily member 10 Homo sapiens 188-193 24708275-10 2015 Interestingly, gluconeogenesis from LP was also increased, up to 10-fold and correlated with a 420% increase in the PEPCK mRNA expression, the enzyme controlling gluconeogenesis from LP. leucylproline 36-38 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 116-121 25986676-8 2015 Compared with wild-type LP mice, Htr3a(-/-)LP mice had increased spontaneous ventricle tarchycardia (VT; 56% vs. 0%, P=0.002), VT inducibility (66% vs. 25%, P=0.002) and mortality (56% vs. 0%, P=0.002). leucylproline 43-45 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 33-38 25757106-13 2015 Animals resuscitated with LP-HX not only demonstrated increased DNA damage at 4 hours versus baseline but also had the lowest C-reactive protein level at 2 hours and 4-hours (p < 0.017). leucylproline 26-28 C-reactive protein Sus scrofa 126-144 25700737-4 2015 P2RX7-evoked autophagy was triggered by LP formation but not Ca(2+) influx or MAPK1-MAPK3 phosphorylation, 2 canonical P2RX7-evoked signals. leucylproline 40-42 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 0-5 25700737-6 2015 Indeed, specific HSP90 inhibitors prevented LP formation, LC3-II accumulation, and cell death in myoblasts and myotubes but not in macrophages. leucylproline 44-46 heat shock protein 86, pseudogene 2 Mus musculus 17-22 25700737-8 2015 The functional significance of the P2RX7 LP is one of the great unknowns of purinergic signaling. leucylproline 41-43 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 35-40 25835180-6 2015 LAT1 score and intensity were significantly higher in the LP than in the SD group, as well as among Gleason score (GS)-low (GS < 7) patients who were associated with low-risk. leucylproline 58-60 solute carrier family 7 member 5 Homo sapiens 0-4 25835180-9 2015 CONCLUSIONS: Independently of GS, aberrant overexpression of LAT1 in prostatic adenocarcinoma could predict LP under EM. leucylproline 108-110 solute carrier family 7 member 5 Homo sapiens 61-65 25835180-10 2015 Although prostate biopsy samples are small, LAT1 may be a novel prognostic biomarker of LP. leucylproline 88-90 solute carrier family 7 member 5 Homo sapiens 44-48 25500075-7 2014 Principal component analysis and consecutive pairwise supervised comparisons demonstrated distinct patterns of expressed miRNAs not only for TP versus LP (e.g., intratumoral down-regulation of miR-214, miR-199a, miR-146a, and miR-125a; P< .05) but also for TC versus LC (including down-regulation within TC of miR-126, miR-99a/100, miR-26a, and miR-125b; P< .05). leucylproline 151-153 microRNA 214 Homo sapiens 193-200 25615273-10 2015 In the sSC contralateral to the OHT eye, a decrease in VGluT2 immunopositive synaptic connections was detected one week post LP, which appeared to be retinotopically linked to the sectorial RGC degeneration patterns. leucylproline 125-127 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 Mus musculus 55-61 26624933-4 2015 LP was defined as presentation with a CD4 count < 350/mm(3) or an AIDS defining event (at any CD4), in the six months following HIV diagnosis. leucylproline 0-2 CD4 molecule Homo sapiens 38-41 26624933-4 2015 LP was defined as presentation with a CD4 count < 350/mm(3) or an AIDS defining event (at any CD4), in the six months following HIV diagnosis. leucylproline 0-2 CD4 molecule Homo sapiens 97-100 25397441-5 2014 LP were defined as patients presenting with CD4 T-cell count below 350 cells/mm(3) or with an AIDS defining event. leucylproline 0-2 CD4 molecule Homo sapiens 44-47 25001523-8 2014 Our data show that wet voice is clearly indicative of LP or LP/ASP in PD patients in case of positive test. leucylproline 60-62 assembly factor for spindle microtubules Homo sapiens 63-66 24998244-8 2014 The LP diet decreased the gene expression of the sodium-glucose-linked transporter 1 (SGLT1/SLC5A1) and GLUT2/SLC2A2 (P< 0 05) and increased the expression of membrane Ca channel (TRPV6) and calbindin compared with the HP diet (P< 0 001). leucylproline 4-6 solute carrier family 5 member 1 Sus scrofa 86-91 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 fucosyltransferase 4 Homo sapiens 130-134 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 TNF receptor superfamily member 8 Homo sapiens 136-140 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 paired box 5 Homo sapiens 146-150 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 BCL6 transcription repressor Homo sapiens 175-179 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 POU class 2 homeobox 2 Homo sapiens 181-185 25394195-8 2014 However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. leucylproline 37-39 POU class 2 homeobox associating factor 1 Homo sapiens 191-195 24998244-8 2014 The LP diet decreased the gene expression of the sodium-glucose-linked transporter 1 (SGLT1/SLC5A1) and GLUT2/SLC2A2 (P< 0 05) and increased the expression of membrane Ca channel (TRPV6) and calbindin compared with the HP diet (P< 0 001). leucylproline 4-6 solute carrier family 5 member 1 Sus scrofa 92-98 24998244-8 2014 The LP diet decreased the gene expression of the sodium-glucose-linked transporter 1 (SGLT1/SLC5A1) and GLUT2/SLC2A2 (P< 0 05) and increased the expression of membrane Ca channel (TRPV6) and calbindin compared with the HP diet (P< 0 001). leucylproline 4-6 solute carrier family 2 member 2 Sus scrofa 104-109 24998244-8 2014 The LP diet decreased the gene expression of the sodium-glucose-linked transporter 1 (SGLT1/SLC5A1) and GLUT2/SLC2A2 (P< 0 05) and increased the expression of membrane Ca channel (TRPV6) and calbindin compared with the HP diet (P< 0 001). leucylproline 4-6 solute carrier family 2 member 2 Sus scrofa 110-116 24998244-8 2014 The LP diet decreased the gene expression of the sodium-glucose-linked transporter 1 (SGLT1/SLC5A1) and GLUT2/SLC2A2 (P< 0 05) and increased the expression of membrane Ca channel (TRPV6) and calbindin compared with the HP diet (P< 0 001). leucylproline 4-6 transient receptor potential cation channel subfamily V member 6 Sus scrofa 183-188 24865627-4 2014 Using in-gel kinase assays, we determined the activities of MPK3 and MPK6 in Arabidopsis thaliana seedlings under both LP and Pi-sufficient (Murashige and Skoog, MS) conditions. leucylproline 119-121 mitogen-activated protein kinase 3 Arabidopsis thaliana 60-64 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 mannose-binding lectin (protein C) 2 Mus musculus 0-3 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 collectin sub-family member 11 Mus musculus 18-30 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 mannan-binding lectin serine peptidase 1 Mus musculus 115-121 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 mannan-binding lectin serine peptidase 2 Mus musculus 123-129 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 mannose-binding lectin (protein C) 2 Mus musculus 155-158 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 RIKEN cDNA 1110004F10 gene Mus musculus 190-194 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 mannose-binding lectin (protein C) 2 Mus musculus 155-158 25070856-2 2014 MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44). leucylproline 39-41 MBL associated serine protease 1 Homo sapiens 232-237 24865627-4 2014 Using in-gel kinase assays, we determined the activities of MPK3 and MPK6 in Arabidopsis thaliana seedlings under both LP and Pi-sufficient (Murashige and Skoog, MS) conditions. leucylproline 119-121 MAP kinase 6 Arabidopsis thaliana 69-73 24865627-7 2014 LP treatment activated MPK3 and MPK6. leucylproline 0-2 mitogen-activated protein kinase 3 Arabidopsis thaliana 23-27 24865627-7 2014 LP treatment activated MPK3 and MPK6. leucylproline 0-2 MAP kinase 6 Arabidopsis thaliana 32-36 24852241-8 2014 Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. leucylproline 45-47 keratin 20 Homo sapiens 85-89 24852241-8 2014 Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. leucylproline 45-47 CD79a molecule Homo sapiens 91-96 24852241-8 2014 Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. leucylproline 45-47 paired box 5 Homo sapiens 98-102 24852241-8 2014 Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. leucylproline 45-47 POU class 2 homeobox 2 Homo sapiens 104-108 24852241-8 2014 Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. leucylproline 45-47 protein tyrosine phosphatase receptor type C Homo sapiens 114-118 24458032-12 2014 Serum interleukin 6 was lower after 4 hours in the LP-SW group compared with LP-NS (p < 0.05). leucylproline 51-53 interleukin-6 Sus scrofa 6-19 24448642-4 2014 In Europeans, LP is strongly associated with, and probably caused by, a single C to T mutation 13,910 bp upstream of the lactase (LCT) gene (-13,910*T). leucylproline 14-16 lactase Homo sapiens 121-128 24448642-4 2014 In Europeans, LP is strongly associated with, and probably caused by, a single C to T mutation 13,910 bp upstream of the lactase (LCT) gene (-13,910*T). leucylproline 14-16 lactase Homo sapiens 130-133 25340007-5 2014 LY6K-specific CTLs were induced through cross-presentation of LY6K172-191-LP in vitro and in vivo. leucylproline 74-76 lymphocyte antigen 6 family member K Homo sapiens 0-4 25340007-6 2014 In addition, LY6K172-191-LP enhanced induction of LY6K-specific CTLs among the peripheral blood mononuclear cells (PBMCs) of head-and-neck malignant tumor (HNMT) patients. leucylproline 25-27 lymphocyte antigen 6 family member K Homo sapiens 13-17 24646820-4 2014 For people lacking the LP trait, the fermentation of milk into yogurt and related products (a process known for >=8500 y) aids milk digestion through the breakdown of some lactose and the provision of beta-galactosidase, which remains active in the gastrointestinal tract. leucylproline 23-25 galactosidase beta 1 Homo sapiens 204-222 24259238-6 2014 Insulin levels were higher in VP than in LP (8.61+-2.48 vs. 3.98+-0.94 mU/L) (p<0.001) and FT infants (8.61+-2.48 vs. 4.56+-1.2 mU/L) (p<0.001). leucylproline 41-43 insulin Homo sapiens 0-7 24600012-8 2014 Accordingly, in contrast to WT mice, TMPRSS2 KO mice were highly tolerant of challenge infection by LP IAVs (H1N1, H3N2, and H7N9) with >=1,000 50% lethal doses (LD50) for WT mice. leucylproline 100-102 transmembrane protease, serine 2 Mus musculus 37-44 24646203-9 2014 After action of APE1, BER can follow one of two subpathways, the short-patch (SP) or long-patch (LP) version, which differ based on the number of nucleotides a polymerase incorporates at the nick site. leucylproline 97-99 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 16-20 24630847-2 2014 However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] trait). leucylproline 143-145 lactase Homo sapiens 122-129 24349316-6 2013 However, C1q depleted human serum strongly opsonized PLY through abundant deposition of C3 activation products, indicating that the LP may have a vital role in activating the human complement system on PLY. leucylproline 132-134 complement C1q A chain Homo sapiens 9-12 24731147-2 2014 LP was defined as presentation with either clinical AIDS events within the calendar year of diagnosis or CD4 < 350/mm(3) and presentation with advanced disease (PAD) was defined as presentation with either clinical AIDS events or CD4 < 200/mm(3). leucylproline 0-2 CD4 molecule Homo sapiens 105-108 25033205-6 2014 LP was defined as a patient accessing services with a CD4 < 350 cells/mm(3). leucylproline 0-2 CD4 molecule Homo sapiens 54-57 24302726-5 2014 The peaks in skeletal Fgf23 expression and urine epinephrine levels, a marker for sympathetic tone, shifted from DP to the light phase (LP) when mice were fed during LP. leucylproline 136-138 fibroblast growth factor 23 Mus musculus 22-27 24734272-9 2014 Furthermore, significant frequencies of CDCA1-specific Th cell responses were detected after short-term in vitro stimulation of peripheral blood mononuclear cells (PBMCs) with CDCA1-LPs in HNC patients (CDCA1(39-64)-LP, 74%; CDCA1(55-78)-LP, 68%), but not in healthy donors. leucylproline 182-184 NUF2 component of NDC80 kinetochore complex Homo sapiens 40-45 24734272-9 2014 Furthermore, significant frequencies of CDCA1-specific Th cell responses were detected after short-term in vitro stimulation of peripheral blood mononuclear cells (PBMCs) with CDCA1-LPs in HNC patients (CDCA1(39-64)-LP, 74%; CDCA1(55-78)-LP, 68%), but not in healthy donors. leucylproline 182-184 NUF2 component of NDC80 kinetochore complex Homo sapiens 176-181 24734272-9 2014 Furthermore, significant frequencies of CDCA1-specific Th cell responses were detected after short-term in vitro stimulation of peripheral blood mononuclear cells (PBMCs) with CDCA1-LPs in HNC patients (CDCA1(39-64)-LP, 74%; CDCA1(55-78)-LP, 68%), but not in healthy donors. leucylproline 182-184 NUF2 component of NDC80 kinetochore complex Homo sapiens 176-181 24734272-9 2014 Furthermore, significant frequencies of CDCA1-specific Th cell responses were detected after short-term in vitro stimulation of peripheral blood mononuclear cells (PBMCs) with CDCA1-LPs in HNC patients (CDCA1(39-64)-LP, 74%; CDCA1(55-78)-LP, 68%), but not in healthy donors. leucylproline 182-184 NUF2 component of NDC80 kinetochore complex Homo sapiens 176-181 24734272-9 2014 Furthermore, significant frequencies of CDCA1-specific Th cell responses were detected after short-term in vitro stimulation of peripheral blood mononuclear cells (PBMCs) with CDCA1-LPs in HNC patients (CDCA1(39-64)-LP, 74%; CDCA1(55-78)-LP, 68%), but not in healthy donors. leucylproline 216-218 NUF2 component of NDC80 kinetochore complex Homo sapiens 40-45 24349316-7 2013 We identified that human L-ficolin is the critical LP recognition molecule that drives LP activation on PLY, while all of the murine LP recognition components fail to bind and activate complement on PLY. leucylproline 51-53 ficolin 2 Homo sapiens 25-34 24349316-7 2013 We identified that human L-ficolin is the critical LP recognition molecule that drives LP activation on PLY, while all of the murine LP recognition components fail to bind and activate complement on PLY. leucylproline 87-89 ficolin 2 Homo sapiens 25-34 24349316-7 2013 We identified that human L-ficolin is the critical LP recognition molecule that drives LP activation on PLY, while all of the murine LP recognition components fail to bind and activate complement on PLY. leucylproline 87-89 ficolin 2 Homo sapiens 25-34 24029115-7 2013 The observed CD4(+) T-cell independent activation and differentiation may be due to LP-induced expression of CD40L by a subset of cognate B-cells. leucylproline 84-86 CD4 molecule Homo sapiens 13-16 24029115-7 2013 The observed CD4(+) T-cell independent activation and differentiation may be due to LP-induced expression of CD40L by a subset of cognate B-cells. leucylproline 84-86 CD40 ligand Homo sapiens 109-114 23792217-7 2013 The LP was larger in NoGo. leucylproline 4-6 reticulon 4 Homo sapiens 21-25 24147098-10 2013 Compared with the HF group, LP and BB peel extracts increased the mRNA expression of PPARalpha and its target genes, such as FAS, PGC-1alpha and PGC-1beta, and GLUT4 in the liver and white adipocyte tissue (WAT). leucylproline 28-30 peroxisome proliferator activated receptor alpha Mus musculus 85-94 24147098-10 2013 Compared with the HF group, LP and BB peel extracts increased the mRNA expression of PPARalpha and its target genes, such as FAS, PGC-1alpha and PGC-1beta, and GLUT4 in the liver and white adipocyte tissue (WAT). leucylproline 28-30 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 160-165 24047970-1 2013 OBJECTIVE: A recent consensus defines "late presentation" (LP) during the course of HIV infection as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells per cubic millimeter. leucylproline 59-61 CD4 molecule Homo sapiens 137-140 24047970-1 2013 OBJECTIVE: A recent consensus defines "late presentation" (LP) during the course of HIV infection as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells per cubic millimeter. leucylproline 59-61 CD4 molecule Homo sapiens 160-163 23714729-7 2013 KIF20A-specific CTLs were induced by vaccination with a KIF20A-LP in vivo. leucylproline 63-65 kinesin family member 20A Homo sapiens 0-6 23714729-7 2013 KIF20A-specific CTLs were induced by vaccination with a KIF20A-LP in vivo. leucylproline 63-65 kinesin family member 20A Homo sapiens 56-62 23792217-10 2013 The larger LP in NoGo marks the cortical inactivation following the earlier cessation of processing in this condition. leucylproline 11-13 reticulon 4 Homo sapiens 17-21 23686493-3 2013 Indeed, when Ig-myelin oligodendrocyte glycoprotein (MOG) carrying the MOG(35-55) epitope was orally administered into either T cell-sufficient or -deficient mice, only the T cell-sufficient hosts yielded CD8alpha(+) and CD8alpha(-) LP DCs that were able to transfer tolerance to a variety of MHC class II-restricted effector T cells. leucylproline 233-235 myelin oligodendrocyte glycoprotein Mus musculus 13-51 23686493-3 2013 Indeed, when Ig-myelin oligodendrocyte glycoprotein (MOG) carrying the MOG(35-55) epitope was orally administered into either T cell-sufficient or -deficient mice, only the T cell-sufficient hosts yielded CD8alpha(+) and CD8alpha(-) LP DCs that were able to transfer tolerance to a variety of MHC class II-restricted effector T cells. leucylproline 233-235 myelin oligodendrocyte glycoprotein Mus musculus 53-56 23686493-4 2013 Surprisingly, these LP DCs upregulated programmed cell death ligand 1 during the initial interaction with MOG-specific T cells and used this inhibitory molecule to suppress activation of T cells regardless of Ag specificity. leucylproline 20-22 myelin oligodendrocyte glycoprotein Mus musculus 106-109 23583201-8 2013 Immunoneutralization of PVN NUCB2/nesfatin-1 with anti-nesfatin-1 IgG during LP, but not dark phase, increased food intake. leucylproline 77-79 nucleobindin 2 Rattus norvegicus 28-33 23583201-8 2013 Immunoneutralization of PVN NUCB2/nesfatin-1 with anti-nesfatin-1 IgG during LP, but not dark phase, increased food intake. leucylproline 77-79 nucleobindin 2 Rattus norvegicus 34-44 23583201-8 2013 Immunoneutralization of PVN NUCB2/nesfatin-1 with anti-nesfatin-1 IgG during LP, but not dark phase, increased food intake. leucylproline 77-79 nucleobindin 2 Rattus norvegicus 55-65 23583201-10 2013 Furthermore, the rise of PVN NUCB2 mRNA during LP was blunted in Zucker-fatty obese rats which exhibited LP-preferential hyperphagia. leucylproline 47-49 nucleobindin 2 Rattus norvegicus 29-34 23583201-10 2013 Furthermore, the rise of PVN NUCB2 mRNA during LP was blunted in Zucker-fatty obese rats which exhibited LP-preferential hyperphagia. leucylproline 105-107 nucleobindin 2 Rattus norvegicus 29-34 23583201-11 2013 The increases in food intake during LP and 24h were significantly corrected by intracerebroventricular injection of nesfatin-1 during LP. leucylproline 36-38 nucleobindin 2 Rattus norvegicus 116-126 23583201-12 2013 These results reveal the diurnal rhythm of PVN NUCB2 mRNA expression characterized by early LP rise, which may serve as a factor to limit LP food intake, contributing to circadian feeding. leucylproline 92-94 nucleobindin 2 Rattus norvegicus 47-52 23583201-12 2013 These results reveal the diurnal rhythm of PVN NUCB2 mRNA expression characterized by early LP rise, which may serve as a factor to limit LP food intake, contributing to circadian feeding. leucylproline 138-140 nucleobindin 2 Rattus norvegicus 47-52 23327608-8 2013 CONCLUSIONS: This study suggests that (i) the distribution of the LP polymorphism is not uniform across the country, (ii) genotyping - 13910C>T is a good diagnostic tool for lactase status in the Portuguese population and (iii) self-reported gastrointestinal complaints are not good predictors of the LP status, implying that a significant part of those complaints may not be related to hypolactasia. leucylproline 66-68 lactase Homo sapiens 177-184 23493397-6 2013 Reconstitution experiments to unravel essential components of the lectin pathway (LP) showed that both ficolin and mannan-binding lectin can activate the LP through natural IgM antibodies (IgM-C2) that recognize phospholipid cell surface modifications on oxidatively stressed RPE cells. leucylproline 82-84 mannose binding lectin 2 Homo sapiens 115-136 23493397-8 2013 Likewise, mouse laser-induced choroidal neovascularization, an injury that involves LP activation, could be increased in antibody-deficient rag1(-/-) mice using the phospholipid-specific IgM-C2. leucylproline 84-86 recombination activating 1 Mus musculus 140-144 23631691-8 2013 The mRNA levels of TLR3, 7, and 8 were significantly up-regulated in PAMs in HP-infected pigs compared to those in groups LP and LP-der. leucylproline 122-124 toll-like receptor 3 Sus scrofa 19-23 23631691-9 2013 Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097. leucylproline 65-67 tumor necrosis factor Homo sapiens 13-22 23631691-9 2013 Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097. leucylproline 65-67 interleukin 1 beta Homo sapiens 27-35 23282080-8 2013 The patterns of expression differed both spatially and temporally, with phases of peak Dio2 expression in the median eminence and tuberoinfundibular sulcus, as well as in the paraventricular zone (PVZ) (maximal under LP), whereas Dio3 expression was always confined to the PVZ (maximal under SP). leucylproline 217-219 type II iodothyronine deiodinase Ovis aries 87-91 22777518-7 2012 Post-transfusion LP ratio changes at T1a [r = -0.42; 95 % confidence interval (CI), -0.66 to -0.098; P = 0.01] and T1b (r = -0.68; 95 % [CI], -0.82 to -0.44; P < 0.001) were significantly correlated with the pre-transfusion LP ratio, but not with baseline demographic characteristics, vital signs, severity scores, hemoglobin level and blood lactate. leucylproline 17-19 podoplanin Homo sapiens 37-40 22844966-11 2013 CONCLUSION: These data demonstrate that LP maintains at least 50% of factor activity and thrombin-generating capacity up to 15 days of refrigerated storage. leucylproline 40-42 coagulation factor II, thrombin Homo sapiens 89-97 24137103-3 2013 METHODS AND FINDINGS: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm(3) or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June 2011. leucylproline 22-24 CD4 molecule Homo sapiens 140-143 22683388-8 2012 CAV significantly increased the LP lesion in sciatic nerves. leucylproline 32-34 caveolin 2 Homo sapiens 0-3 23134409-6 2012 The heteroleptic 1:1 LP complexes 2-4 were also obtained by the one-pot reaction of Mes2Te, Ph3E (E = P, As, Sb) and HO3SCF3. leucylproline 21-23 H3 histone pseudogene 26 Homo sapiens 92-96 23262371-3 2013 Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. leucylproline 53-55 S100 calcium binding protein B Homo sapiens 129-134 23262371-7 2013 RESULTS: S100B pattern in LP infants was characterized by a slight decrease in protein"s concentration from 34 to 35wks. leucylproline 26-28 S100 calcium binding protein B Homo sapiens 9-14 23262371-10 2013 Polynomial type-1 regression analysis showed a significant correlation (R=-0.05; P<0.001) between gestational age and S100B in LP infants considering either the whole study population or when corrected for gender. leucylproline 130-132 S100 calcium binding protein B Homo sapiens 121-126 23262371-11 2013 CONCLUSIONS: S100B in LP infants is gestational age and gender dependent. leucylproline 22-24 S100 calcium binding protein B Homo sapiens 13-18 23262371-12 2013 The present reference curve, for S100B in LP period, offers additional support to protein"s neurotrophic role and suggests that gestational age and gender have to be taken into due account, whenever S100B is measured, in order to avoid bias factors. leucylproline 42-44 S100 calcium binding protein B Homo sapiens 33-38 22749136-5 2013 At birth INSR (P=.032), PPARalpha (P=.0006) and CYP2C34 (P<.0001) showed significant differences between LP and CO. CYP2C34 was significantly increased in the high-protein group (HP) compared to CO (P=.001). leucylproline 108-110 insulin receptor Sus scrofa 9-13 22749136-5 2013 At birth INSR (P=.032), PPARalpha (P=.0006) and CYP2C34 (P<.0001) showed significant differences between LP and CO. CYP2C34 was significantly increased in the high-protein group (HP) compared to CO (P=.001). leucylproline 108-110 peroxisome proliferator activated receptor alpha Sus scrofa 24-33 22749136-5 2013 At birth INSR (P=.032), PPARalpha (P=.0006) and CYP2C34 (P<.0001) showed significant differences between LP and CO. CYP2C34 was significantly increased in the high-protein group (HP) compared to CO (P=.001). leucylproline 108-110 cytochrome P450 family 2 subfamily C member 297 Sus scrofa 48-55 22749136-5 2013 At birth INSR (P=.032), PPARalpha (P=.0006) and CYP2C34 (P<.0001) showed significant differences between LP and CO. CYP2C34 was significantly increased in the high-protein group (HP) compared to CO (P=.001). leucylproline 108-110 cytochrome P450 family 2 subfamily C member 297 Sus scrofa 119-126 22749136-6 2013 At weaning, INSR was significantly higher expressed in LP than in CO (P=.018). leucylproline 55-57 insulin receptor Sus scrofa 12-16 22749136-9 2013 CpG sites in the 5"-flanking region of CYP2C34 showed a significant positive correlation with transcript amount in LP (nt -137: R=0.67, P<.0001; nt -112: R=0.54, P=.003). leucylproline 115-117 cytochrome P450 family 2 subfamily C member 297 Sus scrofa 39-46 22749136-10 2013 In NR3C1 methylation, differences in the CpG island were negatively correlated with gene expression data in LP (R=-0.34, P=.032). leucylproline 108-110 nuclear receptor subfamily 3 group C member 1 Sus scrofa 3-8 22749136-11 2013 The mean of methylation of PPARalpha over CpG sites from nt -220 to -11 was significantly increased in the LP group compared with CO (P=.043). leucylproline 107-109 peroxisome proliferator activated receptor alpha Sus scrofa 27-36 23077076-6 2012 Plasma adiponectin varied in quadratic fashion with the highest levels in LP, a maximal reduction of 45% on the day after parturition and a progressive return to LP values over the next 8 wk. leucylproline 74-76 adiponectin, C1Q and collagen domain containing Bos taurus 7-18 23077076-6 2012 Plasma adiponectin varied in quadratic fashion with the highest levels in LP, a maximal reduction of 45% on the day after parturition and a progressive return to LP values over the next 8 wk. leucylproline 162-164 adiponectin, C1Q and collagen domain containing Bos taurus 7-18 23077076-7 2012 Adiponectin circulated nearly exclusively in high molecular weight complexes in LP, and this distribution remained unaffected in EL. leucylproline 80-82 adiponectin, C1Q and collagen domain containing Bos taurus 0-11 21964914-10 2012 MUC1 expression with HP and DP pattern was significantly higher in primary lung cancer than in PMT, whereas, MUC1 expression with LP pattern yielded a significantly high positive rate in PMT. leucylproline 130-132 mucin 1, cell surface associated Homo sapiens 109-113 22923507-14 2012 Matrix metalloproteinase-2 transcript levels were downregulated in LP (LP = 0.47 +- 0.03 vs. NP = 1 +- 0.01, normalized to NP, P < 0.001) and was restored at PP7 (0.70 +- 0.1, P < 0.001 vs. LP). leucylproline 67-69 matrix metallopeptidase 2 Mus musculus 0-26 22923507-14 2012 Matrix metalloproteinase-2 transcript levels were downregulated in LP (LP = 0.47 +- 0.03 vs. NP = 1 +- 0.01, normalized to NP, P < 0.001) and was restored at PP7 (0.70 +- 0.1, P < 0.001 vs. LP). leucylproline 71-73 matrix metallopeptidase 2 Mus musculus 0-26 22923507-14 2012 Matrix metalloproteinase-2 transcript levels were downregulated in LP (LP = 0.47 +- 0.03 vs. NP = 1 +- 0.01, normalized to NP, P < 0.001) and was restored at PP7 (0.70 +- 0.1, P < 0.001 vs. LP). leucylproline 71-73 matrix metallopeptidase 2 Mus musculus 0-26 26019815-7 2012 A Spearman"s rho test showed a strong positive correlation between functional LP activity and C5a desArg. leucylproline 78-80 complement C5a receptor 1 Homo sapiens 94-97 22665650-9 2012 Different subpopulations of CD8+ lymphocytes were markedly increased in SP piglets at 23 d of age compared with piglets exposed to LP (treatment x time: P < 0.05). leucylproline 131-133 CD8a molecule Homo sapiens 28-31 22335781-2 2012 We investigated the expressions of all the tomato 14-3-3 gene family members (TFT1-TFT12) under low phosphorus stress (LP) and found that TFT6 belongs to the later responsive gene while TFT7 belongs to the early responsive gene. leucylproline 119-121 14-3-3 protein 1 Solanum lycopersicum 78-82 22335781-2 2012 We investigated the expressions of all the tomato 14-3-3 gene family members (TFT1-TFT12) under low phosphorus stress (LP) and found that TFT6 belongs to the later responsive gene while TFT7 belongs to the early responsive gene. leucylproline 119-121 14-3-3 protein 6 Solanum lycopersicum 138-142 22335781-4 2012 TFT6 overexpressing plants showed reduced starch synthase activity, reduced starch content but enhanced sucrose loading into phloem in the shoot under LP. leucylproline 151-153 14-3-3 protein 6 Solanum lycopersicum 0-4 22335781-5 2012 TFT7 overexpressing plants had much enhanced H+ flux along their root tip and activity of plasma membrane H+-ATPase in the roots under LP. leucylproline 135-137 14-3-3 protein 7 Solanum lycopersicum 0-4 22335781-5 2012 TFT7 overexpressing plants had much enhanced H+ flux along their root tip and activity of plasma membrane H+-ATPase in the roots under LP. leucylproline 135-137 plasma membrane ATPase 1 Solanum lycopersicum 106-115 22335781-6 2012 Our results suggest that TFT6 and TFT7 play different roles in plant adaption to LP. leucylproline 81-83 14-3-3 protein 6 Solanum lycopersicum 25-29 22335781-6 2012 Our results suggest that TFT6 and TFT7 play different roles in plant adaption to LP. leucylproline 81-83 14-3-3 protein 7 Solanum lycopersicum 34-38 22335781-7 2012 TFT6 acts mainly in leaves and is involved in the systemic response to LP by regulating leaf carbon allocation and increasing phloem sucrose transport to promote root growth, while TFT7 directly functions in root by activating root plasma membrane H+-ATPase to release more protons under LP. leucylproline 71-73 14-3-3 protein 6 Solanum lycopersicum 0-4 22335781-7 2012 TFT6 acts mainly in leaves and is involved in the systemic response to LP by regulating leaf carbon allocation and increasing phloem sucrose transport to promote root growth, while TFT7 directly functions in root by activating root plasma membrane H+-ATPase to release more protons under LP. leucylproline 71-73 plasma membrane ATPase 1 Solanum lycopersicum 248-257 22335781-7 2012 TFT6 acts mainly in leaves and is involved in the systemic response to LP by regulating leaf carbon allocation and increasing phloem sucrose transport to promote root growth, while TFT7 directly functions in root by activating root plasma membrane H+-ATPase to release more protons under LP. leucylproline 288-290 14-3-3 protein 6 Solanum lycopersicum 0-4 22335781-7 2012 TFT6 acts mainly in leaves and is involved in the systemic response to LP by regulating leaf carbon allocation and increasing phloem sucrose transport to promote root growth, while TFT7 directly functions in root by activating root plasma membrane H+-ATPase to release more protons under LP. leucylproline 288-290 14-3-3 protein 7 Solanum lycopersicum 181-185 22564073-4 2012 Five days after the change from short photoperiod (SP) to long photoperiod (LP), the profiles of Per2 and Rev-erbalpha expression in the rostral, middle and caudal regions of the SCN were desynchronized and those in the liver were modulated as in mice fully entrained to LP. leucylproline 76-78 nuclear receptor subfamily 1, group D, member 1 Mus musculus 106-118 22728862-4 2012 METHODS: This is a clinicopathologic study of 8 patients with a diagnosis of PEO, who had LP muscle biopsies as part of oculoplastic procedures. leucylproline 90-92 twinkle mtDNA helicase Homo sapiens 77-80 21538948-1 2012 The aim of this study is to define the diagnostic role of Liqui-Prep (LP) technique for the diagnosis of thyroid lesions and to assess interobserver variabilities. leucylproline 70-72 prolyl endopeptidase Homo sapiens 64-68 22344266-5 2012 The LP genes showed distinct dependency on the duration of ERK activity, and they were also induced during the latent process of PACAP- and forskolin-induced cell differentiation. leucylproline 4-6 Eph receptor B1 Rattus norvegicus 59-62 22344266-5 2012 The LP genes showed distinct dependency on the duration of ERK activity, and they were also induced during the latent process of PACAP- and forskolin-induced cell differentiation. leucylproline 4-6 adenylate cyclase activating polypeptide 1 Rattus norvegicus 129-134 21856919-10 2011 Collagen and elastin contents were significantly increased in LPLN rats by ~10 and 25%, respectively, compared with LP (P < 0.05). leucylproline 62-64 elastin Rattus norvegicus 13-20 22336916-6 2012 We found that the three proteins that contact telomere DNA, POT1, TRF1 and TRF2, enhance the rate of individual steps of LP-BER and stimulate the complete reconstituted LP-BER pathway. leucylproline 121-123 protection of telomeres 1 Homo sapiens 60-64 22336916-6 2012 We found that the three proteins that contact telomere DNA, POT1, TRF1 and TRF2, enhance the rate of individual steps of LP-BER and stimulate the complete reconstituted LP-BER pathway. leucylproline 121-123 telomeric repeat binding factor 1 Homo sapiens 66-70 22336916-6 2012 We found that the three proteins that contact telomere DNA, POT1, TRF1 and TRF2, enhance the rate of individual steps of LP-BER and stimulate the complete reconstituted LP-BER pathway. leucylproline 121-123 telomeric repeat binding factor 2 Homo sapiens 75-79 23317197-7 2012 Overexpression of p53 and PCNA were higher in LSCC (62.7%, 57.8%) than in LP (38%, 33.3%) (P<0.005, and P<0.005, respectively). leucylproline 74-76 tumor protein p53 Homo sapiens 18-21 23317197-7 2012 Overexpression of p53 and PCNA were higher in LSCC (62.7%, 57.8%) than in LP (38%, 33.3%) (P<0.005, and P<0.005, respectively). leucylproline 74-76 proliferating cell nuclear antigen Homo sapiens 26-30 23166589-5 2012 The activities of the 26 S proteasome subunits beta1 (caspase-like), and beta2 (trypsin-like) were significantly decreased in LP (beta1:83.26 +- 1.96%; beta2:74.74 +- 1.7%, normalized to NP) whereas beta5 (chymotrypsin-like) activity was not altered by pregnancy but significantly decreased 1 day post-partum. leucylproline 126-128 hemoglobin, beta adult major chain Mus musculus 47-52 23166589-5 2012 The activities of the 26 S proteasome subunits beta1 (caspase-like), and beta2 (trypsin-like) were significantly decreased in LP (beta1:83.26 +- 1.96%; beta2:74.74 +- 1.7%, normalized to NP) whereas beta5 (chymotrypsin-like) activity was not altered by pregnancy but significantly decreased 1 day post-partum. leucylproline 126-128 hemoglobin, beta adult minor chain Mus musculus 73-78 23166589-5 2012 The activities of the 26 S proteasome subunits beta1 (caspase-like), and beta2 (trypsin-like) were significantly decreased in LP (beta1:83.26 +- 1.96%; beta2:74.74 +- 1.7%, normalized to NP) whereas beta5 (chymotrypsin-like) activity was not altered by pregnancy but significantly decreased 1 day post-partum. leucylproline 126-128 hemoglobin, beta adult major chain Mus musculus 130-135 23166589-5 2012 The activities of the 26 S proteasome subunits beta1 (caspase-like), and beta2 (trypsin-like) were significantly decreased in LP (beta1:83.26 +- 1.96%; beta2:74.74 +- 1.7%, normalized to NP) whereas beta5 (chymotrypsin-like) activity was not altered by pregnancy but significantly decreased 1 day post-partum. leucylproline 126-128 hemoglobin, beta adult minor chain Mus musculus 152-157 23166589-5 2012 The activities of the 26 S proteasome subunits beta1 (caspase-like), and beta2 (trypsin-like) were significantly decreased in LP (beta1:83.26 +- 1.96%; beta2:74.74 +- 1.7%, normalized to NP) whereas beta5 (chymotrypsin-like) activity was not altered by pregnancy but significantly decreased 1 day post-partum. leucylproline 126-128 integrin beta 5 Mus musculus 199-204 22951784-5 2012 The largest between-group differences in the LP were revealed in the frontal areas for N1 and P3 in the left hemisphere and for N2 - in the right one. leucylproline 45-47 leukemia NUP98 fusion partner 1 Homo sapiens 87-96 22210038-7 2011 LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively. leucylproline 0-2 interleukin 4 Mus musculus 101-105 22210038-7 2011 LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively. leucylproline 0-2 interleukin 1 beta Mus musculus 107-115 22210038-7 2011 LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively. leucylproline 0-2 tumor necrosis factor Mus musculus 121-130 22210038-10 2011 Based on these findings, LP may improve allergic diseases, such as anaphylaxis, atopic dermatitis, rhinitis, and pruritus by inhibiting the expression of IgE-switching cytokine IL-4 and proinflammatory cytokines IL-1beta and TNF-alpha via NF-kappaB and AP-1 signaling pathways. leucylproline 25-27 interleukin 4 Mus musculus 177-181 22210038-10 2011 Based on these findings, LP may improve allergic diseases, such as anaphylaxis, atopic dermatitis, rhinitis, and pruritus by inhibiting the expression of IgE-switching cytokine IL-4 and proinflammatory cytokines IL-1beta and TNF-alpha via NF-kappaB and AP-1 signaling pathways. leucylproline 25-27 interleukin 1 beta Mus musculus 212-220 22210038-10 2011 Based on these findings, LP may improve allergic diseases, such as anaphylaxis, atopic dermatitis, rhinitis, and pruritus by inhibiting the expression of IgE-switching cytokine IL-4 and proinflammatory cytokines IL-1beta and TNF-alpha via NF-kappaB and AP-1 signaling pathways. leucylproline 25-27 tumor necrosis factor Mus musculus 225-234 22384447-8 2011 CONCLUSION: GnRH antagonist MDP with OCP pretreatment is at least as effective as GnRH agonist low-dose LP in poor responders and can benefit the poor responders by reducing the amount and duration of FSH required for follicular maturation. leucylproline 104-106 gonadotropin releasing hormone 1 Homo sapiens 82-86 21990311-4 2011 Plasma FGF21 was nearly undetectable in LP, peaked on the day of parturition, and then stabilized at lower, chronically elevated concentrations during the energy deficit of EL. leucylproline 40-42 fibroblast growth factor 21 Bos taurus 7-12 21990311-8 2011 Expression of beta-Klotho and its subset of interacting FGF receptors was modestly affected by the transition from LP to EL in liver but not in WAT. leucylproline 115-117 klotho beta Bos taurus 14-25 21990311-8 2011 Expression of beta-Klotho and its subset of interacting FGF receptors was modestly affected by the transition from LP to EL in liver but not in WAT. leucylproline 115-117 fibroblast growth factor 21 Bos taurus 56-59 21965716-7 2011 LP contains high concentrations of sVEGFR1, and high density of VEGFR1(+) neutrophilic granulocytes, in which mRNA expression is shifted toward the soluble VEGFR1 isoform. leucylproline 0-2 fms related receptor tyrosine kinase 1 Homo sapiens 36-42 21911594-6 2012 Results showed that VEGF significantly increased permeability (x10(7) mum(3)/min) from 9.7 +- 3.5 to 21.0 +- 1.5 (P<0.05) in NP veins exposed to NP plasma, that was prevented when LP veins were exposed to LP plasma; (9.7+-3.8; P>0.05). leucylproline 183-185 vascular endothelial growth factor A Rattus norvegicus 20-24 21911594-6 2012 Results showed that VEGF significantly increased permeability (x10(7) mum(3)/min) from 9.7 +- 3.5 to 21.0 +- 1.5 (P<0.05) in NP veins exposed to NP plasma, that was prevented when LP veins were exposed to LP plasma; (9.7+-3.8; P>0.05). leucylproline 208-210 vascular endothelial growth factor A Rattus norvegicus 20-24 21911594-7 2012 Both LP plasma and soluble FMS-like tyrosine-kinase 1 (sFlt1) in NP plasma abolished VEGF-induced BBB permeability in NP veins (9.5+-2.9 and 12+-2.6; P>0.05). leucylproline 5-7 vascular endothelial growth factor A Rattus norvegicus 85-89 21856919-11 2011 Both MMP-2 and tissue inhibitors of metalloproteinase-2 as assessed by immunofluorescence were lower in the endothelium (reduction of 60%) and adventitia (reduction of 50%) of LPLN compared with LP mUA. leucylproline 176-178 matrix metallopeptidase 2 Rattus norvegicus 5-10 21974696-1 2011 Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. leucylproline 146-148 mannose binding lectin 2 Homo sapiens 0-22 21849603-7 2011 Most essential amino acids, IGF-I, C-peptide, and urea increased significantly in both the LP and HP groups compared with the breastfed group. leucylproline 91-93 insulin like growth factor 1 Homo sapiens 28-33 21786338-2 2011 Here we provide evidence for the presence of XRCC1 in different complexes of sizes from 200 to 1500 kDa, and we show that immunoprecipitates using XRCC1 as bait are capable of complete repair of AP sites via both short patch (SP) and long patch (LP) base excision repair (BER). leucylproline 246-248 X-ray repair cross complementing 1 Homo sapiens 45-50 21786338-2 2011 Here we provide evidence for the presence of XRCC1 in different complexes of sizes from 200 to 1500 kDa, and we show that immunoprecipitates using XRCC1 as bait are capable of complete repair of AP sites via both short patch (SP) and long patch (LP) base excision repair (BER). leucylproline 246-248 X-ray repair cross complementing 1 Homo sapiens 147-152 20798384-11 2011 Our findings suggest that Mt3 could play a critical role in zinc homeostasis in rat LP. leucylproline 84-86 metallothionein 3 Rattus norvegicus 26-29 21974696-1 2011 Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. leucylproline 146-148 ficolin 2 Homo sapiens 30-39 21974696-1 2011 Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. leucylproline 146-148 MBL associated serine protease 2 Homo sapiens 44-76 21974696-1 2011 Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. leucylproline 146-148 MBL associated serine protease 2 Homo sapiens 78-84 21974696-3 2011 The objective of the present study is to clarify the significance of the LP in maintenance hemodialysis (HD) patients, especially in terms of MBL levels. leucylproline 73-75 mannose binding lectin 2 Homo sapiens 142-145 21974696-12 2011 It is postulated that the elevation of concentration of the two components of the LP, L-ficolin and MASP-2, may compensate for the insufficient activity of the LP in MBL deficiency. leucylproline 82-84 ficolin 2 Homo sapiens 86-95 21510865-11 2011 Some of the main strategies of LP applicable to PSA decision making are a default decision rule, framing of decision aids, and timing of the decision. leucylproline 31-33 kallikrein related peptidase 3 Homo sapiens 48-51 20533280-6 2011 However, cancer cells in LP exhibited resurgent E-cadherin (p = 0.011), beta-catenin (p < 0.001), and Geminin (p = 0.037) expression and reduced MMP-7 (p = 0.038) and Laminin-5 gamma2 (p = 0.001) expression in comparison with cancer cells in BVBs. leucylproline 25-27 cadherin 1 Homo sapiens 48-58 20533280-6 2011 However, cancer cells in LP exhibited resurgent E-cadherin (p = 0.011), beta-catenin (p < 0.001), and Geminin (p = 0.037) expression and reduced MMP-7 (p = 0.038) and Laminin-5 gamma2 (p = 0.001) expression in comparison with cancer cells in BVBs. leucylproline 25-27 catenin beta 1 Homo sapiens 72-84 20533280-6 2011 However, cancer cells in LP exhibited resurgent E-cadherin (p = 0.011), beta-catenin (p < 0.001), and Geminin (p = 0.037) expression and reduced MMP-7 (p = 0.038) and Laminin-5 gamma2 (p = 0.001) expression in comparison with cancer cells in BVBs. leucylproline 25-27 geminin DNA replication inhibitor Homo sapiens 105-112 20533280-6 2011 However, cancer cells in LP exhibited resurgent E-cadherin (p = 0.011), beta-catenin (p < 0.001), and Geminin (p = 0.037) expression and reduced MMP-7 (p = 0.038) and Laminin-5 gamma2 (p = 0.001) expression in comparison with cancer cells in BVBs. leucylproline 25-27 matrix metallopeptidase 7 Homo sapiens 148-153 21974696-1 2011 Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. leucylproline 146-148 mannose binding lectin 2 Homo sapiens 24-27 21142127-4 2011 Three independently arising Lp alleles have been described for Vangl2: D255E, S464N, and R259L. leucylproline 28-30 VANGL planar cell polarity protein 2 Homo sapiens 63-69 21215285-6 2011 IL-10 -1082/-819/-592 and IFNG +874 SNPs were associated with the intensity of LP responses to C trachomatis antigens. leucylproline 79-81 interleukin 10 Homo sapiens 0-5 21215285-6 2011 IL-10 -1082/-819/-592 and IFNG +874 SNPs were associated with the intensity of LP responses to C trachomatis antigens. leucylproline 79-81 interferon gamma Homo sapiens 26-30 21215285-7 2011 These cytokines also interact with each other and a cumulative effect of IL-10 -1082 and IFNG +874 genotypes was seen in LP responses to C trachomatis antigens. leucylproline 121-123 interleukin 10 Homo sapiens 73-78 21215285-7 2011 These cytokines also interact with each other and a cumulative effect of IL-10 -1082 and IFNG +874 genotypes was seen in LP responses to C trachomatis antigens. leucylproline 121-123 interferon gamma Homo sapiens 89-93 20063407-6 2011 From 194 cases, ASC or AGC were diagnosed in 72 cases (37.1%) from LP and 68 cases (35.1%) from Pap smear. leucylproline 67-69 PYD and CARD domain containing Homo sapiens 16-19 21063899-5 2011 The increased O(2)(-) production and mRNA expression levels of NAD(P)H oxidase subunits Nox4 and p47phox were found to be significantly reduced in the aorta of diabetic rats treated with LP. leucylproline 187-189 NADPH oxidase 4 Rattus norvegicus 88-92 21063899-5 2011 The increased O(2)(-) production and mRNA expression levels of NAD(P)H oxidase subunits Nox4 and p47phox were found to be significantly reduced in the aorta of diabetic rats treated with LP. leucylproline 187-189 neutrophil cytosolic factor 1 Rattus norvegicus 97-104 21063899-6 2011 The mRNA expression of MCP-1 and CCR2, and the protein expression of iNOS were found to be increased in the aorta of untreated diabetic rats, whereas these levels were significantly lower in the LP-treated group. leucylproline 195-197 C-C motif chemokine ligand 2 Rattus norvegicus 23-28 21063899-6 2011 The mRNA expression of MCP-1 and CCR2, and the protein expression of iNOS were found to be increased in the aorta of untreated diabetic rats, whereas these levels were significantly lower in the LP-treated group. leucylproline 195-197 C-C motif chemokine receptor 2 Rattus norvegicus 33-37 21063899-6 2011 The mRNA expression of MCP-1 and CCR2, and the protein expression of iNOS were found to be increased in the aorta of untreated diabetic rats, whereas these levels were significantly lower in the LP-treated group. leucylproline 195-197 nitric oxide synthase 2 Rattus norvegicus 69-73 20855877-6 2010 In this study, we compared the in vitro characteristics and T cell-stimulatory capacities of a human 30-mer HA-1 LP with the 9-mer HA-1 SP. leucylproline 113-115 Rho GTPase activating protein 45 Homo sapiens 108-112 21424034-5 2011 By contrast, MUM1/IRF-4 protein scored negative in the majority of LP cells, but is reported to be expressed in almost all cases of cHL. leucylproline 67-69 PWWP domain containing 3A, DNA repair factor Homo sapiens 13-17 21424034-5 2011 By contrast, MUM1/IRF-4 protein scored negative in the majority of LP cells, but is reported to be expressed in almost all cases of cHL. leucylproline 67-69 interferon regulatory factor 4 Homo sapiens 18-23 20855877-7 2010 DCs presented the HA-1 LP and SP and expanded HA-1-specific cytotoxic T cell lines. leucylproline 23-25 Rho GTPase activating protein 45 Homo sapiens 18-22 20855877-8 2010 As hypothesized, HA-1 LP presentation, but not SP presentation, was largely restricted to activated DCs and was nearly absent on other hematopoietic cells. leucylproline 22-24 Rho GTPase activating protein 45 Homo sapiens 17-21 20855877-10 2010 Finally, the decay of HA-1 LP and SP presentation on DCs was comparable. leucylproline 27-29 Rho GTPase activating protein 45 Homo sapiens 22-26 20434341-4 2010 Studies in birds have identified the transcription factor Eya3 as the first molecular response activated by long photoperiod (LP). leucylproline 126-128 eyes absent homolog 3 Ovis aries 58-62 21423372-6 2010 PPARgamma inhibition reduced dilation to acetylcholine and sodium nitroprusside in PCA from NP (p < 0.05 vs. LP-GW), but not LP rats. leucylproline 112-114 peroxisome proliferator-activated receptor gamma Rattus norvegicus 0-9 20349192-4 2010 This review focuses on how dysfunction of hBest1 is related to the accumulation of yellow pigment and a decreased LP. leucylproline 114-116 bestrophin 1 Homo sapiens 42-48 20434341-6 2010 We also demonstrate TAC1 (encoding the tachykinins substance P and neurokinin A) to be strongly activated by LP within the sheep PT. leucylproline 109-111 protachykinin-1 Ovis aries 20-24 20353955-3 2010 Previously, LP was mapped to a 6 cm region on ECA1 containing the candidate gene TRPM1 (Transient Receptor Potential Cation Channel, Subfamily M, Member 1) and decreased expression of this gene, measured by qRT-PCR, was identified as the likely cause of both spotting and ocular phenotypes. leucylproline 12-14 transient receptor potential cation channel subfamily M member 1 Equus caballus 81-86 20353955-3 2010 Previously, LP was mapped to a 6 cm region on ECA1 containing the candidate gene TRPM1 (Transient Receptor Potential Cation Channel, Subfamily M, Member 1) and decreased expression of this gene, measured by qRT-PCR, was identified as the likely cause of both spotting and ocular phenotypes. leucylproline 12-14 transient receptor potential cation channel subfamily M member 1 Equus caballus 88-154 20053664-3 2010 Both Best1(+/W93C)and Best1(W93C/W93C) mice had normal ERG a- and b-waves, but exhibited an altered LP luminance response reminiscent of that observed in BVMD patients. leucylproline 100-102 bestrophin 1 Mus musculus 5-10 20015952-4 2010 We genetically defined lactase persistence (LP) in 31 720 individuals from eight European population-based studies and one family study by genotyping or imputing the European LP variant (rs4988235). leucylproline 44-46 lactase Homo sapiens 23-30 20053664-1 2010 Mutations in BEST1, encoding bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD), a dominantly inherited macular degeneration characterized by a diminished electrooculogram light peak (LP), lipofuscin in retinal pigment epithelial cells (RPE), and fluid- and debris-filled retinal detachments. leucylproline 203-205 bestrophin 1 Mus musculus 13-18 20053664-1 2010 Mutations in BEST1, encoding bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD), a dominantly inherited macular degeneration characterized by a diminished electrooculogram light peak (LP), lipofuscin in retinal pigment epithelial cells (RPE), and fluid- and debris-filled retinal detachments. leucylproline 203-205 bestrophin 1 Mus musculus 29-41 20053664-1 2010 Mutations in BEST1, encoding bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD), a dominantly inherited macular degeneration characterized by a diminished electrooculogram light peak (LP), lipofuscin in retinal pigment epithelial cells (RPE), and fluid- and debris-filled retinal detachments. leucylproline 203-205 bestrophin 1 Mus musculus 43-48 20053664-3 2010 Both Best1(+/W93C)and Best1(W93C/W93C) mice had normal ERG a- and b-waves, but exhibited an altered LP luminance response reminiscent of that observed in BVMD patients. leucylproline 100-102 bestrophin 1 Mus musculus 22-27 19716852-7 2010 MF LP nanoparticles had higher level of Bcl-2 antisense uptake and showed more efficient down-regulation of Bcl-2 protein level than BM LP nanoparticles. leucylproline 3-5 BCL2 apoptosis regulator Homo sapiens 40-45 19703477-5 2010 PARP1 upon interaction with nicked LP BER DNA intermediated, formed after gap-filling, was shown to suppress the subsequent steps in LP pathway. leucylproline 35-37 poly [ADP-ribose] polymerase 1 Bos taurus 0-5 19716852-7 2010 MF LP nanoparticles had higher level of Bcl-2 antisense uptake and showed more efficient down-regulation of Bcl-2 protein level than BM LP nanoparticles. leucylproline 3-5 BCL2 apoptosis regulator Homo sapiens 108-113 19905983-6 2009 The number of macrophages, levels of MCP-1 mRNA expression and degree of glomerular fibrosis increased in untreated LP and these levels were significantly lower in 1.0%LP-treated rats. leucylproline 116-118 C-C motif chemokine ligand 2 Rattus norvegicus 37-42 19714206-2 2009 Lactase gene haplotype conservation around a polymorphism strongly associated with LP in Europeans (-13,910 C/T) indicates that the derived allele is recent in origin and has been subject to strong positive selection. leucylproline 83-85 lactase Homo sapiens 0-7 19523618-2 2009 GnRH antagonist MDP with OCP pretreatment was at least as effective as GnRH agonist low-dose LP in low responders, and can benefit the low responders by reducing the amount of FSH and the number of days of stimulation required for follicular maturation. leucylproline 93-95 gonadotropin releasing hormone 1 Homo sapiens 71-75 19716852-1 2010 A multi-inlet microfluidic hydrodynamic focusing (MF) system to prepare lipopolyplex (LP) containing Bcl-2 antisense deoxyoligonucleotide (ODN) was developed and evaluated. leucylproline 86-88 BCL2 apoptosis regulator Homo sapiens 101-106 19716183-7 2009 MBL levels were directly correlated to the MBL2 combined genotypes: HP patients showed higher mean MBL concentration of 4044 ng/mL, LP patients were characterized by a mean of 905 ng/mL whereas those with DP combined genotype presented extremely low levels of MBL (mean value of 74 ng/mL) (p=0.0005). leucylproline 132-134 mannose binding lectin 2 Homo sapiens 0-3 19716183-9 2009 MBL was undetectable in situ in both LP and DP patients. leucylproline 37-39 mannose binding lectin 2 Homo sapiens 0-3 19716183-10 2009 MBL2 expression, although at very low levels, was found for the HP group, the LP and the DP group as well. leucylproline 78-80 mannose binding lectin 2 Homo sapiens 0-4 17957548-8 2007 Both HP and LP CAPs stimulated the release of proinflammatory cytokines tumor necrosis factor (TNF) alpha and interleukin (IL)-6 after 6 h of exposures. leucylproline 12-14 tumor necrosis factor Homo sapiens 72-105 18389318-8 2009 However, the rise in IL-6 and CRP in OP group was significantly more robust than in LP group. leucylproline 84-86 interleukin 6 Homo sapiens 21-25 20548851-5 2009 RESULTS: The caspase-1 and STAT-6 mRNA expression levels from the SP lesional skin of the patients were increased compared with the caspase-1 and STAT-6 mRNA expression levels from SP non-lesional skin or normal skin, but these expression levels from the SP non-lesional skin were not significantly different from those of the LP non-lesional skin. leucylproline 327-329 caspase 1 Homo sapiens 13-22 20548851-7 2009 The MMP-1 mRNA expressions in both the LP and SP lesional skin were increased compared with those in the normal skin (p=0.028 and p=0.007 respectively). leucylproline 39-41 matrix metallopeptidase 1 Homo sapiens 4-9 20548851-8 2009 The MMP-9 mRNA expression in the LP non-lesional skin was elevated compared with the MMP-9 mRNA expression in the SP non-lesional skin (p=0.047). leucylproline 33-35 matrix metallopeptidase 9 Homo sapiens 4-9 20548851-10 2009 CONCLUSION: The increased expression of MMP-9 mRNA in the LP non-lesional skin compared to that of the SP non-lesional skin in the psoriatic skin suggests that the increased MMP-9 mRNA expression is related to the large size type of lesion. leucylproline 58-60 matrix metallopeptidase 9 Homo sapiens 40-45 20548851-10 2009 CONCLUSION: The increased expression of MMP-9 mRNA in the LP non-lesional skin compared to that of the SP non-lesional skin in the psoriatic skin suggests that the increased MMP-9 mRNA expression is related to the large size type of lesion. leucylproline 58-60 matrix metallopeptidase 9 Homo sapiens 174-179 18550075-2 2008 The different effects of reaction conditions including the concentration of Mn(2+), incubation temperature and pH on prolidase (PLD, EC 3.4.13.9) activity in erythrocyte lysates against three different substrates, Gly-Pro, Val-Pro and Leu-Pro were investigated. leucylproline 235-242 peptidase D Homo sapiens 117-126 18550075-2 2008 The different effects of reaction conditions including the concentration of Mn(2+), incubation temperature and pH on prolidase (PLD, EC 3.4.13.9) activity in erythrocyte lysates against three different substrates, Gly-Pro, Val-Pro and Leu-Pro were investigated. leucylproline 235-242 peptidase D Homo sapiens 128-131 18460017-1 2008 The possibility of simultaneous measurement of the classical pathway (CP), mannan-binding lectin (MBL)--lectin pathway (LP) and alternative pathway (AP) of complement activation by the recently developed Wielisa method allowed us to investigate the in vivo significance of the C1-inhibitor (C1INH) in three complement activation pathways. leucylproline 120-122 mannose binding lectin 2 Homo sapiens 98-101 18460017-6 2008 Depressed LP activity was found in patients compared with controls (P = 0.0008) in homozygous carriers of the normal MBL genotype (A/A), but not in carriers of variant genotypes (A/O, O/O). leucylproline 10-12 mannose binding lectin 2 Homo sapiens 117-120 18460017-9 2008 We conclude that the activation of LP might also occur in subjects with C1INH deficiency, which is reflected by the low MASP-2 and C4 levels. leucylproline 35-37 MBL associated serine protease 2 Homo sapiens 120-126 18375863-5 2008 Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. leucylproline 206-208 period circadian clock 1 Mus musculus 24-29 17507267-6 2007 Biochemical analysis showed that the CAT, GST, and MDA levels were higher in LP patients than in the control subjects, and the GSH level was lower. leucylproline 77-79 catalase Homo sapiens 37-40 17507267-6 2007 Biochemical analysis showed that the CAT, GST, and MDA levels were higher in LP patients than in the control subjects, and the GSH level was lower. leucylproline 77-79 glutathione S-transferase kappa 1 Homo sapiens 42-45 17975996-9 2007 RESULTS: The LP ponies were insulin resistant (median insulin sensitivity of 0.27 x 10(4) L min(-1) mU(-1) in LP ponies, compared with 0.64 x 10(4) L min(-1) mU(-1) in control ponies). leucylproline 13-15 insulin Homo sapiens 28-35 17975996-9 2007 RESULTS: The LP ponies were insulin resistant (median insulin sensitivity of 0.27 x 10(4) L min(-1) mU(-1) in LP ponies, compared with 0.64 x 10(4) L min(-1) mU(-1) in control ponies). leucylproline 13-15 insulin Homo sapiens 54-61 17975996-10 2007 Median insulin concentration in LP ponies was significantly greater than that in control ponies at pasture, decreased in response to feeding hay, and was markedly increased (5.5-fold) following the feeding of inulin with hay. leucylproline 32-34 insulin Homo sapiens 7-14 17975996-11 2007 The LP ponies had a greater increase in serum insulin concentration at 19 hours after dexamethasone administration (median, 222.9 mU/L), compared with control ponies (45.6 mU/L). leucylproline 4-6 insulin Homo sapiens 46-53 19291371-7 2009 RESULTS: In vitro, Tf-LP-G3139 was more effective in inducing down regulation of Bcl-2 in K562 cells than non-targeted LP-G3139, free G3139 and mismatched control ODN-G4126 in the same formulation. leucylproline 22-24 BCL2 apoptosis regulator Homo sapiens 81-86 19291371-8 2009 In vivo Tf-LP-G3139 was less effective than free G3139 in Bcl-2 down regulation. leucylproline 11-13 B cell leukemia/lymphoma 2 Mus musculus 58-63 19587437-5 2009 RESULTS: The mRNA expression level of NMBR in the PT group was significantly higher than that in the NP, EP, LP and PP groups (P<0.05), but this difference was not observed in the MP group (P>0.05). leucylproline 109-111 neuromedin B receptor Mus musculus 38-42 19587437-7 2009 NF-kappaB-P65 DNA binding activity at PT group was remarkably higher than that in the NP, LP and PP groups (P<0.05). leucylproline 90-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 19587437-8 2009 The expression of IL-6 mRNA was significantly higher than that in the NP, LP and PP groups (P<0.05), its protein expression in PT and LP groups was significantly higher than that in the NP and PP groups (P<0.05). leucylproline 74-76 interleukin 6 Mus musculus 18-22 19587437-8 2009 The expression of IL-6 mRNA was significantly higher than that in the NP, LP and PP groups (P<0.05), its protein expression in PT and LP groups was significantly higher than that in the NP and PP groups (P<0.05). leucylproline 137-139 interleukin 6 Mus musculus 18-22 19587437-9 2009 The expression of HSP70 mRNA in the PT group was significantly higher than that in the NP and PP groups (P<0.05), and the protein of HSP70 was significantly up-regulated in PT and PP groups compared with in NP and LP groups (P<0.05). leucylproline 217-219 heat shock protein 1B Mus musculus 18-23 19587437-9 2009 The expression of HSP70 mRNA in the PT group was significantly higher than that in the NP and PP groups (P<0.05), and the protein of HSP70 was significantly up-regulated in PT and PP groups compared with in NP and LP groups (P<0.05). leucylproline 217-219 heat shock protein 1B Mus musculus 136-141 19517215-3 2009 The aim of this study was to evaluate levels of MBL and MBL-dependent activity of the lectin pathway (LP) of complement in the course of pregnancy in diabetic mothers, based on genetic background. leucylproline 102-104 mannose binding lectin 2 Homo sapiens 56-59 19298763-20 2009 MMP-9 expression showed significant increase around the ischemic lesion areas of the UKHP group and significant decrease in the cortical areas of the LP and HP groups but no significant difference in the basal ganglia of rats of all groups. leucylproline 150-152 matrix metallopeptidase 9 Rattus norvegicus 0-5 18421458-6 2009 LP TNF and IL-6 levels were high in cultures stimulated with LPS compared with the preoperative period (PREOP) (P = 0.007; P = 0.008, respectively). leucylproline 0-2 tumor necrosis factor Homo sapiens 3-6 18421458-7 2009 Stimulation with BCG led to increased levels of TNF and IL-6 during the LP period compared to control (P = 0.001; P = 0.04, respectively). leucylproline 72-74 interleukin 6 Homo sapiens 56-60 19444556-5 2009 The aim of this study was to investigate whether the difference of ETbr(CO2) (D-ETbr(CO2)) between the dependent and the nondependent lungs during TLV in the lateral decubitus position (LP) could be a predictive factor for the severity of oxygenation disorder under subsequent OLV. leucylproline 186-188 complement C2 Homo sapiens 67-75 19444556-11 2009 RESULTS: The decrease of PaO2/FIO2 at 15 min during OLV in LP correlated with the reduction of the D-ETbr(CO2) predetermined during TLV in LP (r = 0.698; P < 0.01). leucylproline 59-61 complement C2 Homo sapiens 99-109 19444556-11 2009 RESULTS: The decrease of PaO2/FIO2 at 15 min during OLV in LP correlated with the reduction of the D-ETbr(CO2) predetermined during TLV in LP (r = 0.698; P < 0.01). leucylproline 139-141 complement C2 Homo sapiens 99-109 19444556-12 2009 CONCLUSION: The D-ETbr(CO2) predetermined during TLV in LP could be a predictive factor for the severity of oxygenation disorder after starting OLV in LP. leucylproline 56-58 complement C2 Homo sapiens 16-26 19444556-12 2009 CONCLUSION: The D-ETbr(CO2) predetermined during TLV in LP could be a predictive factor for the severity of oxygenation disorder after starting OLV in LP. leucylproline 151-153 complement C2 Homo sapiens 16-26 18815207-4 2008 Hepatic expression of the short (Lepr-a) and long (Lepr-b) isoforms was 40% higher during EL (8 days postpartum) than LP (30 days prepartum). leucylproline 118-120 leptin receptor Bos taurus 33-37 18815207-4 2008 Hepatic expression of the short (Lepr-a) and long (Lepr-b) isoforms was 40% higher during EL (8 days postpartum) than LP (30 days prepartum). leucylproline 118-120 leptin receptor Bos taurus 51-55 18815207-8 2008 In adipose tissue, Lepr expression was increased 10-fold during the transition from LP to EL. leucylproline 84-86 leptin receptor Bos taurus 19-23 18657447-2 2008 In this study we demonstrated the ontogenic and differential expression of complement key component genes (C3, C1r/s, C4, C6, Bf, MBL and MASP) of the classical pathway (CP), alternative pathway (AP), lectin pathway (LP) and lytic pathway, and their responses to challenge with LPS during development. leucylproline 217-219 complement component 1, r subcomponent Danio rerio 111-114 17957548-8 2007 Both HP and LP CAPs stimulated the release of proinflammatory cytokines tumor necrosis factor (TNF) alpha and interleukin (IL)-6 after 6 h of exposures. leucylproline 12-14 interleukin 6 Homo sapiens 110-128 16469990-5 2006 RESULTS: Rates of bone calcium deposition increased significantly from EP to LP (P = 0.001) and were significantly associated with serum PTH during LP (P < or = 0.01). leucylproline 148-150 parathyroid hormone Homo sapiens 137-140 17236819-9 2007 Thus, the apoptotic 24kDa-fragment of PARP1 may be considered as more efficient in inhibition of the LP than SP pathway and the effect may depend on the ratio of p24 to the repair enzymes catalyzing precise stages of BER. leucylproline 101-103 poly [ADP-ribose] polymerase 1 Bos taurus 38-43 17429849-5 2007 These results suggest common attributes of both diseases, but expression of both CTLA-4 and FoxP3 on the same cell subset is essential to fully prevent LP disease. leucylproline 152-154 cytotoxic T-lymphocyte-associated protein 4 Mus musculus 81-87 17429849-5 2007 These results suggest common attributes of both diseases, but expression of both CTLA-4 and FoxP3 on the same cell subset is essential to fully prevent LP disease. leucylproline 152-154 forkhead box P3 Mus musculus 92-97 17413099-10 2007 The insulin (-21%) and C-peptide (-14%) AUCs decreased in the LP group but did not change significantly in the HP group. leucylproline 62-64 insulin Homo sapiens 4-11 17515877-8 2007 Exercise increased SDF-1 alpha only in LP, and the FLT-3 increase was greater in LP than EP. leucylproline 81-83 fms related receptor tyrosine kinase 3 Homo sapiens 51-56 16943296-8 2006 Thus, functional alterations of the nef gene are present in both LP and LTNP, suggesting that Nef defectiveness in vitro is not necessarily associated with the long-term maintenance of LTNP status. leucylproline 65-67 Nef Human immunodeficiency virus 1 36-39 16636205-7 2006 When stimulated with ATP, which increases [Ca++]I, retinal pigment epithelial cells derived from Vmd2-/- mice exhibited a fivefold greater response than Vmd2+/+ littermates, indicating that best-1 can suppress the rise in [Ca2+]I associated with the LP. leucylproline 250-252 bestrophin 1 Mus musculus 190-196 16636205-8 2006 We conclude that VDCCs regulated by a beta4 subunit are required to generate the LP and that best-1 antagonizes the LP luminance response potentially via its ability to modulate VDCC function. leucylproline 116-118 bestrophin 1 Mus musculus 93-99 17705243-9 2007 PSA HL TTF differed among PSA HL categories: 4.2, 2.3, and 0.9 months for R, LP, and IP patients, respectively, and their respective median OS were 27, 19.7, and 12.3 months (P = 0.0001). leucylproline 77-79 aminopeptidase puromycin sensitive Homo sapiens 0-10 17705243-9 2007 PSA HL TTF differed among PSA HL categories: 4.2, 2.3, and 0.9 months for R, LP, and IP patients, respectively, and their respective median OS were 27, 19.7, and 12.3 months (P = 0.0001). leucylproline 77-79 aminopeptidase puromycin sensitive Homo sapiens 0-3 17499201-10 2007 On the other hand, the release of TNF-alpha and IL-10 induced by LP in PBMCs was inhibited by PRP while NP inhibited the release of IFN-gamma and IL-10. leucylproline 65-67 tumor necrosis factor Homo sapiens 34-43 17499201-10 2007 On the other hand, the release of TNF-alpha and IL-10 induced by LP in PBMCs was inhibited by PRP while NP inhibited the release of IFN-gamma and IL-10. leucylproline 65-67 interleukin 10 Homo sapiens 48-53 17610376-7 2007 The median number of CD34(+) cells injected via LP was 0.7 x 10(6) (range 0.45 to 1.22 x 10(6)). leucylproline 48-50 CD34 molecule Homo sapiens 21-25 17610376-9 2007 We suggested for the first time that autologous bone marrow CD34(+) cells labeled with magnetic nanoparticles delivered into the spinal cord via LP technique migrated into the injured site in patients with chronic SCI. leucylproline 145-147 CD34 molecule Homo sapiens 60-64 17376851-8 2007 Our results identify Ca(V)1.3 as the principal pore-forming subunit of VDCCs involved in stimulating the ERG LP. leucylproline 109-111 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 21-29 17302608-4 2007 RESULTS: Comparison of mean values of relative LP for E-cadherin and beta-catenin in tumor tissue shows that levels of E-cadherin protein are significantly lower (259.67-116.23; t=22.7; p=0.000). leucylproline 47-49 cadherin 1 Homo sapiens 54-64 17302608-4 2007 RESULTS: Comparison of mean values of relative LP for E-cadherin and beta-catenin in tumor tissue shows that levels of E-cadherin protein are significantly lower (259.67-116.23; t=22.7; p=0.000). leucylproline 47-49 cadherin 1 Homo sapiens 119-129 17302608-5 2007 The comparison of mean values of the relative LP of E-cadherin in melanoma to the LP in the adjacent normal skin also shows that the expression of E-cadherin in tumor is significantly lower (256.06-169.87; t=11.55, p=0.000). leucylproline 46-48 cadherin 1 Homo sapiens 52-62 17302608-5 2007 The comparison of mean values of the relative LP of E-cadherin in melanoma to the LP in the adjacent normal skin also shows that the expression of E-cadherin in tumor is significantly lower (256.06-169.87; t=11.55, p=0.000). leucylproline 46-48 cadherin 1 Homo sapiens 147-157 17302608-5 2007 The comparison of mean values of the relative LP of E-cadherin in melanoma to the LP in the adjacent normal skin also shows that the expression of E-cadherin in tumor is significantly lower (256.06-169.87; t=11.55, p=0.000). leucylproline 82-84 cadherin 1 Homo sapiens 147-157 17318857-11 2007 All LP patients are off insulin and do not require pancreatic enzyme supplementation. leucylproline 4-6 insulin Homo sapiens 24-31 16691312-1 2006 OBJECTIVE: There are controversial reports in conscious animals regarding the role of cyclooxygenase-2 in late preconditioning (LP). leucylproline 128-130 prostaglandin G/H synthase 2 Ovis aries 86-102 16636205-3 2006 Although the LP is thought to be generated by best-1, we find enhanced LP luminance responsiveness with normal amplitude in Vmd2-/- mice and no differences in cellular Cl- currents in comparison to Vmd2+/+ littermates. leucylproline 13-15 bestrophin 1 Mus musculus 46-52 16216231-8 2006 Wortmannin and LY294002 prevented both RPP improvement and decrease in LDH, CK, and TnI release in LP and PostC groups. leucylproline 99-101 troponin I3, cardiac type Rattus norvegicus 84-87 15378610-1 2004 We investigated whether certain hydrophobic dipeptides, Leu-Ile, Leu-Pro, and Pro-Ile, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) synthesis in cultured neurons and found only Leu-Ile to be an active dipeptide. leucylproline 65-72 glial cell line derived neurotrophic factor Mus musculus 174-217 16548336-5 2006 Whether mammary-gland quarters or cows were the unit of analysis, the HP/LP ratio was negatively related to the SCC (P < 0.04), which explained more than 50% of the SCC variability. leucylproline 73-75 SCC Bos taurus 112-115 16548336-5 2006 Whether mammary-gland quarters or cows were the unit of analysis, the HP/LP ratio was negatively related to the SCC (P < 0.04), which explained more than 50% of the SCC variability. leucylproline 73-75 SCC Bos taurus 168-171 15905452-6 2005 In within-lactation analyses with BF and LP models, likelihood ratio tests revealed that the fit improved significantly up to random regression order of 5 for EB1 and 4 for EB2, independently of the fixed regression order. leucylproline 41-43 microtubule associated protein RP/EB family member 1 Bos taurus 159-168 15905452-7 2005 For EB1 analyses with LP, improvement was marginal albeit significant even for higher random regression order. leucylproline 22-24 microtubule associated protein RP/EB family member 1 Bos taurus 4-7 15677340-5 2005 Western analysis revealed that the major AQP4 band at approximately 32 kDa was significantly elevated in MP, LP, and PP animals compared with NP by 9-, 22-, and 17-fold, respectively. leucylproline 109-111 aquaporin 4 Homo sapiens 41-45 16202865-10 2005 Also cortical Na+-H+ exchanger-1 (NHE-1) protein expression declines steadily during the course of pregnancy from MP to LP compared with that in NP rats, and cortical Na+-H+ exchanger-3 (NHE-3) protein expression is significantly lower in MP and LP compared with NP rats. leucylproline 120-122 solute carrier family 9 member A1 Rattus norvegicus 14-32 16202865-10 2005 Also cortical Na+-H+ exchanger-1 (NHE-1) protein expression declines steadily during the course of pregnancy from MP to LP compared with that in NP rats, and cortical Na+-H+ exchanger-3 (NHE-3) protein expression is significantly lower in MP and LP compared with NP rats. leucylproline 120-122 solute carrier family 9 member A1 Rattus norvegicus 34-39 16202865-10 2005 Also cortical Na+-H+ exchanger-1 (NHE-1) protein expression declines steadily during the course of pregnancy from MP to LP compared with that in NP rats, and cortical Na+-H+ exchanger-3 (NHE-3) protein expression is significantly lower in MP and LP compared with NP rats. leucylproline 246-248 solute carrier family 9 member A3 Rattus norvegicus 167-185 16202865-10 2005 Also cortical Na+-H+ exchanger-1 (NHE-1) protein expression declines steadily during the course of pregnancy from MP to LP compared with that in NP rats, and cortical Na+-H+ exchanger-3 (NHE-3) protein expression is significantly lower in MP and LP compared with NP rats. leucylproline 246-248 solute carrier family 9 member A3 Rattus norvegicus 187-192 16032370-4 2005 The LP was evaluated by monitoring thiobarbituric acid reactive substances (TBARS) in the kidneys, liver and lungs, and validated by including a group treated with an antioxidant, superoxide dismutase (CuZnSOD 50,000 IU/kg), in the study. leucylproline 4-6 superoxide dismutase 1 Rattus norvegicus 202-209 15900362-8 2005 All the cases of LP demonstrated the characteristic phenotype of this variant (CD45RB+, CD20+, CD15-, CD30-). leucylproline 17-19 keratin 20 Homo sapiens 88-92 15900362-8 2005 All the cases of LP demonstrated the characteristic phenotype of this variant (CD45RB+, CD20+, CD15-, CD30-). leucylproline 17-19 fucosyltransferase 4 Homo sapiens 95-99 15900362-8 2005 All the cases of LP demonstrated the characteristic phenotype of this variant (CD45RB+, CD20+, CD15-, CD30-). leucylproline 17-19 TNF receptor superfamily member 8 Homo sapiens 102-106 15692220-6 2005 RESULTS: Increased ACE and AT(1) mRNA expression was found in cortex and medulla of LP compared to NP rats. leucylproline 84-86 angiotensin I converting enzyme Rattus norvegicus 19-22 15692220-13 2005 CONCLUSION: Both the recovery of H(+)-ATPase activity in OMCD segments induced by losartan and the increased expression of AT(1 )receptor suggest angiotensin II modulation of proton ATPase activity on this duct segments in LP rats. leucylproline 223-225 angiotensinogen Rattus norvegicus 146-160 15456783-2 2004 Mutations in the Vangl2 gene cause a neural tube defect (craniorachischisis) characteristic of the looptail (Lp) mouse. leucylproline 109-111 VANGL planar cell polarity 2 Mus musculus 17-23 15456783-7 2004 In addition, we show that the two known Vangl2 loss-of-function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. leucylproline 104-106 VANGL planar cell polarity 2 Mus musculus 40-46 15510547-15 2004 The present study suggests an inverse relationship between LP and CORT. leucylproline 59-61 CORT Gallus gallus 66-70 15456783-7 2004 In addition, we show that the two known Vangl2 loss-of-function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. leucylproline 104-106 dishevelled segment polarity protein 1 Mus musculus 169-173 15456783-7 2004 In addition, we show that the two known Vangl2 loss-of-function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. leucylproline 104-106 dishevelled segment polarity protein 2 Mus musculus 175-179 15456783-7 2004 In addition, we show that the two known Vangl2 loss-of-function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. leucylproline 104-106 dishevelled segment polarity protein 3 Mus musculus 185-189 15054412-2 2004 Recently, a single nucleotide polymorphism C (-13910) T, residing 14 kb from the 5" end of the lactase (LCT) gene was shown to be associated with LP. leucylproline 146-148 lactase Homo sapiens 95-102 15054412-2 2004 Recently, a single nucleotide polymorphism C (-13910) T, residing 14 kb from the 5" end of the lactase (LCT) gene was shown to be associated with LP. leucylproline 146-148 lactase Homo sapiens 104-107 15199065-5 2004 However, the second LP is changed to isoleucylprolyl (IP) in TRPC1, -C4, and -C5, and valylprolyl (VP) in TRPC3, -C6, and -C7. leucylproline 20-22 transient receptor potential cation channel subfamily C member 1 Homo sapiens 61-66 15199065-5 2004 However, the second LP is changed to isoleucylprolyl (IP) in TRPC1, -C4, and -C5, and valylprolyl (VP) in TRPC3, -C6, and -C7. leucylproline 20-22 transient receptor potential cation channel subfamily C member 3 Homo sapiens 106-111 15199065-13 2004 Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively. leucylproline 34-36 FKBP prolyl isomerase 1A pseudogene 3 Homo sapiens 94-100 15199065-13 2004 Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively. leucylproline 34-36 FKBP prolyl isomerase 4 Homo sapiens 105-111 15199065-13 2004 Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively. leucylproline 34-36 transient receptor potential cation channel subfamily C member 3 Homo sapiens 129-134 15199065-13 2004 Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively. leucylproline 34-36 transient receptor potential cation channel subfamily C member 1 Homo sapiens 148-153 15100095-8 2004 ANG II type 1 receptor (AT(1)R) protein abundance was low in the newborn LP kidney (P < 0.05) but rose above control values by 28 days of age (P < 0.05); the rise was associated with an increase in AT(1)R subtype A (P < 0.01), but not subtype B, mRNA level. leucylproline 73-75 angiotensin II receptor type 1 Homo sapiens 0-30 15100095-8 2004 ANG II type 1 receptor (AT(1)R) protein abundance was low in the newborn LP kidney (P < 0.05) but rose above control values by 28 days of age (P < 0.05); the rise was associated with an increase in AT(1)R subtype A (P < 0.01), but not subtype B, mRNA level. leucylproline 73-75 angiotensin II receptor type 1 Homo sapiens 24-30 15106988-6 2004 The Pb(II) ion in 1 has an average Pb-N = 2.63 A to four N-donors from the macrocyclic ring, and four O-donors (average Pb-O = 2.77 A) from the amide pendant donors of the macrocycle, with a water molecule placed with Pb-O = 3.52 A above the proposed site of the lone pair (Lp) on Pb. leucylproline 274-276 submaxillary gland androgen regulated protein 3B Homo sapiens 4-10 15106988-9 2004 A water situated 3.52 A above the proposed site of the lone pair on Pb(II) in 1 is oriented in such a way that it might be thought to be forming a Pb-Lp.H-O-H hydrogen bond. leucylproline 150-152 submaxillary gland androgen regulated protein 3B Homo sapiens 68-74 15106988-13 2004 One of the short Hg-L bonds is replaced in the Pb(II) structures by the lone pair (Lp), which is opposite the short Pb-L bond, or in some cases 2-4 shorter Pb-L bonds. leucylproline 83-85 submaxillary gland androgen regulated protein 3B Homo sapiens 47-53 15025575-8 2004 Tight junction protein (TJP1), which lies within the LP interval on ECA1, was used to determine the homologous chromosomes in humans (HSA15) and mice (mouse chromosome 7). leucylproline 53-55 tight junction protein 1 Homo sapiens 24-28 15025575-8 2004 Tight junction protein (TJP1), which lies within the LP interval on ECA1, was used to determine the homologous chromosomes in humans (HSA15) and mice (mouse chromosome 7). leucylproline 53-55 ECA1 Homo sapiens 68-72 15025575-9 2004 We propose that the pink eyed dilution (p) gene and transient receptor potential cation channel subfamily M, member 1 (TRPM1) are positional candidate genes for LP. leucylproline 161-163 transient receptor potential cation channel subfamily M member 1 Equus caballus 52-117 15025575-9 2004 We propose that the pink eyed dilution (p) gene and transient receptor potential cation channel subfamily M, member 1 (TRPM1) are positional candidate genes for LP. leucylproline 161-163 transient receptor potential cation channel subfamily M member 1 Equus caballus 119-124 16146884-8 2004 The CD34 content of the final LP was predicted by doubling the value of total CD34 cells at the mid-run (MRp-CD34). leucylproline 30-32 CD34 molecule Homo sapiens 4-8 17301384-8 2004 Interestingly, serum levels of IgG2b (another Th2-type immunoglobulin) in LP mice were significantly higher than those in CG and RG mice. leucylproline 74-76 immunoglobulin heavy constant gamma 2B Mus musculus 31-36 17301384-8 2004 Interestingly, serum levels of IgG2b (another Th2-type immunoglobulin) in LP mice were significantly higher than those in CG and RG mice. leucylproline 74-76 heart and neural crest derivatives expressed 2 Mus musculus 46-49 15099362-8 2004 However, IL-18 mRNA expression was significantly different in the lesions of LP psoriasis in comparison with those of SP psoriasis. leucylproline 77-79 interleukin 18 Homo sapiens 9-14 15099362-9 2004 CONCLUSIONS: The results indicate that proinflammatory type 1 genes regulated by IFN-gamma are similarly increased in both SP and LP psoriasis, but a potential difference in IL-18 exists between these disease forms. leucylproline 130-132 interferon gamma Homo sapiens 81-90 16146884-2 2004 However, during a series of leukapheresis procedures (LP) the CD34 value on the final HPC product may not be available for testing until late evening, sometimes resulting in additional, retrospectively unnecessary, LP in order to ensure an adequate HPC collection (>5x10(6) CD34/kg). leucylproline 54-56 CD34 molecule Homo sapiens 62-66 16146884-3 2004 We hypothesized that an estimate of the CD34 content of HPC products prior to 16:00 h on the day of LP would permit improved HPC collection planning. leucylproline 100-102 CD34 molecule Homo sapiens 40-44 16146884-4 2004 We therefore assessed the effectiveness of predicting the total amount of CD34 cells that would be collected in a given LP by either (a) the concentration of CD34 cells/microL in peripheral blood prior to LP (pre-CD34) or (b) the predicted total amount of CD34 cells to be collected based on sampling the LP product at the mid-point of each LP. leucylproline 120-122 CD34 molecule Homo sapiens 74-78 16146884-4 2004 We therefore assessed the effectiveness of predicting the total amount of CD34 cells that would be collected in a given LP by either (a) the concentration of CD34 cells/microL in peripheral blood prior to LP (pre-CD34) or (b) the predicted total amount of CD34 cells to be collected based on sampling the LP product at the mid-point of each LP. leucylproline 205-207 CD34 molecule Homo sapiens 74-78 16146884-4 2004 We therefore assessed the effectiveness of predicting the total amount of CD34 cells that would be collected in a given LP by either (a) the concentration of CD34 cells/microL in peripheral blood prior to LP (pre-CD34) or (b) the predicted total amount of CD34 cells to be collected based on sampling the LP product at the mid-point of each LP. leucylproline 205-207 CD34 molecule Homo sapiens 74-78 16146884-8 2004 The CD34 content of the final LP was predicted by doubling the value of total CD34 cells at the mid-run (MRp-CD34). leucylproline 30-32 CD34 molecule Homo sapiens 78-82 16146884-8 2004 The CD34 content of the final LP was predicted by doubling the value of total CD34 cells at the mid-run (MRp-CD34). leucylproline 30-32 ATP binding cassette subfamily C member 1 Homo sapiens 105-108 16146884-8 2004 The CD34 content of the final LP was predicted by doubling the value of total CD34 cells at the mid-run (MRp-CD34). leucylproline 30-32 CD34 molecule Homo sapiens 78-82 16146884-13 2004 The mean number of CD34/kg collected per LP in the patients/donors was 3.4x10(6) CD34/kg (0.05-18.94). leucylproline 41-43 CD34 molecule Homo sapiens 19-23 16146884-15 2004 However, the study group had a significantly lower median number of LP (three vs. two; P<0.02) to obtain the required collection of 5x10(6) CD34 cells/kg. leucylproline 68-70 CD34 molecule Homo sapiens 143-147 16146884-18 2004 Early availability of mid-run CD34 values was associated with a significant reduction in the number of LP required to collect 5x10(6) CD34 cells/kg, without reduction in the number of CD34 cells for transplant or prolongation of days to neutrophil or platelet engraftment. leucylproline 103-105 CD34 molecule Homo sapiens 30-34 16146884-18 2004 Early availability of mid-run CD34 values was associated with a significant reduction in the number of LP required to collect 5x10(6) CD34 cells/kg, without reduction in the number of CD34 cells for transplant or prolongation of days to neutrophil or platelet engraftment. leucylproline 103-105 CD34 molecule Homo sapiens 134-138 16146884-18 2004 Early availability of mid-run CD34 values was associated with a significant reduction in the number of LP required to collect 5x10(6) CD34 cells/kg, without reduction in the number of CD34 cells for transplant or prolongation of days to neutrophil or platelet engraftment. leucylproline 103-105 CD34 molecule Homo sapiens 134-138 12900918-8 2003 In the medial LP, tectothalamic terminals labeled by the transport of neuronal tracers or substance P immunocytochemistry can form tubular clusters that surround the proximal dendrites of relay cells. leucylproline 14-16 tachykinin precursor 1 Homo sapiens 90-101 15034954-2 2004 Recently, COX-2 inhibitors have also been found to block late preconditioning (LP) protection. leucylproline 79-81 cytochrome c oxidase subunit II Ovis aries 10-15 14639017-7 2003 The abundance and distribution of the C x 43 signal was assessed in relation to LP. leucylproline 80-82 gap junction protein alpha 1 Homo sapiens 38-44 14639017-10 2003 The percent tissue area of C x 43 in the LP (+) group was significantly lower than that in the LP (-) group (p=0.02). leucylproline 41-43 gap junction protein alpha 1 Homo sapiens 27-33 14639017-11 2003 Furthermore, C x 43 protein in the LP (+) group was distributed more heterogeneously than that in the LP (-) group (p=0.001). leucylproline 35-37 gap junction protein alpha 1 Homo sapiens 13-19 14639017-12 2003 The heterogeneous expression of C x 43 protein may contribute to impaired ventricular conduction, which may be related to the LP detected on SAECG. leucylproline 126-128 gap junction protein alpha 1 Homo sapiens 32-38 14973346-3 2004 Our aim was to evaluate the effects of a beta-blocker on LP in patients receiving thrombolytic therapy. leucylproline 57-59 amyloid beta precursor protein Homo sapiens 39-45 14583388-2 2003 During the first postnatal month, nNOS was expressed in many cells within the pulvinar nucleus and medial subdivision of the LP nucleus; fewer neurons in the lateral LP nucleus were stained by the nNOS antibody. leucylproline 125-127 nitric oxide synthase 1 Homo sapiens 34-38 12881203-6 2003 At steady states, the absolute increase in plasma leptin was greater in LP than in EL cows (2.4 vs. 0.4 ng/ml). leucylproline 72-74 leptin Bos taurus 50-56 12906864-3 2003 We have recently identified a positional candidate for Lp on chromosome 1, designated as Ltap. leucylproline 55-57 VANGL planar cell polarity 2 Mus musculus 89-93 12493641-8 2003 Using C1q-blocking and MBL-blocking mAb, it was confirmed that both the LP and the CP contribute to complement activation by mannan. leucylproline 72-74 complement C1q A chain Homo sapiens 6-9 12837736-7 2003 P. carinii-specific LP could be considered for doubtful situations, i.e. for a safer clinical decision of discontinuing or restarting prophylaxis in patients with a low CD4 nadir or experiencing a sudden CD4 decrease under highly active antiretroviral therapy (HAART). leucylproline 20-22 CD4 molecule Homo sapiens 169-172 12837736-7 2003 P. carinii-specific LP could be considered for doubtful situations, i.e. for a safer clinical decision of discontinuing or restarting prophylaxis in patients with a low CD4 nadir or experiencing a sudden CD4 decrease under highly active antiretroviral therapy (HAART). leucylproline 20-22 CD4 molecule Homo sapiens 204-207 12681946-2 2003 Conversely, inappropriate activation of Notch1 in LP inhibits B cell development and causes ectopic T cell development in the bone marrow. leucylproline 50-52 notch receptor 1 Homo sapiens 40-46 12681946-6 2003 Here, we describe how some of these mechanisms might regulate Notch activity in LP during the T/B lineage decision. leucylproline 80-82 notch receptor 1 Homo sapiens 62-67 12493641-1 2003 Mannan-binding lectin (MBL) is a major initiator of the lectin pathway (LP) of complement. leucylproline 72-74 mannose binding lectin 2 Homo sapiens 0-21 12493641-1 2003 Mannan-binding lectin (MBL) is a major initiator of the lectin pathway (LP) of complement. leucylproline 72-74 mannose binding lectin 2 Homo sapiens 23-26 12493641-4 2003 We have now developed a functional LP assay that enables the specific quantification of autologous MBL-dependent complement activation in human serum. leucylproline 35-37 mannose binding lectin 2 Homo sapiens 99-102 12493641-8 2003 Using C1q-blocking and MBL-blocking mAb, it was confirmed that both the LP and the CP contribute to complement activation by mannan. leucylproline 72-74 mannose binding lectin 2 Homo sapiens 23-26 12493641-12 2003 Evaluation of the LP in the presence of mAb 2204 showed a strong dose-dependent deposition of C4, C3, and C5b-9 using serum from MBL-wildtype (AA) but not MBL-mutant donors (AB or BB genotype), indicating that complement activation under these conditions is MBL-dependent and C1q-independent. leucylproline 18-20 mannose binding lectin 2 Homo sapiens 129-132 12493641-12 2003 Evaluation of the LP in the presence of mAb 2204 showed a strong dose-dependent deposition of C4, C3, and C5b-9 using serum from MBL-wildtype (AA) but not MBL-mutant donors (AB or BB genotype), indicating that complement activation under these conditions is MBL-dependent and C1q-independent. leucylproline 18-20 complement C1q A chain Homo sapiens 276-279 12682870-6 2002 Cyclo(leu-pro) was found to be active against twelve VRE strains, including E. faecium (vanA, vanB), and E. faecalis (vanA, vanB), that had been isolated over a period three years (1998-2000). leucylproline 6-13 D-alanine--D-lactate ligase Enterococcus faecium 94-98 12682870-6 2002 Cyclo(leu-pro) was found to be active against twelve VRE strains, including E. faecium (vanA, vanB), and E. faecalis (vanA, vanB), that had been isolated over a period three years (1998-2000). leucylproline 6-13 D-alanine--D-lactate ligase Enterococcus faecalis 124-128 12399528-4 2002 However, expression of ZnT2 in LP and DP was unaffected by castration. leucylproline 31-33 solute carrier family 30 member 2 Rattus norvegicus 23-27 12209875-5 2002 In contrast, the identical treatment of LP with PT diminished all ACA in response to PTH, Gpp(NH)p, and FOR. leucylproline 40-42 parathyroid hormone Homo sapiens 85-88 12372551-4 2002 Exposure to a light pulse (LP) 1 h prior to sacrifice led to increased Fos expression in subjects maintained for 2 weeks in constant gravity (either at approximately 0 or 1 G). leucylproline 27-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 71-74 12372551-5 2002 Within 24 h of a gravitational change (launch or landing), the Fos response to LP was abolished. leucylproline 79-81 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 63-66 12372551-7 2002 FRA responses to LP showed a mirror image pattern, with significant responses 24 h after launch and landing, but no responses after 2 weeks at approximately 0 or 1 G. There were no direct FRA responses to gravity changes. leucylproline 17-19 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 0-3 12372551-8 2002 The juxtafacial and retrofacial parts of the LPGi, which integrate somatosensory/acoustic and autonomic signals, respectively, also showed gravity-related increases in LP-induced FRA expression 24 h after launch and landing. leucylproline 45-47 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 179-182 12458885-6 2002 Intranuclear c-Jun was present in the NS subtype and stronger immunoreactivity for TGF-betaRII was evident in the LP subtype. leucylproline 114-116 transforming growth factor beta receptor 2 Homo sapiens 83-94 12209875-12 2002 In contrast, cycloheximide completely reversed the PT associated decrease in FOR and as well as PTH dependent ACA in LP. leucylproline 117-119 parathyroid hormone Homo sapiens 96-99 11689657-9 2001 Molecular genetic analysis involving recombinants between Mah/I4062M and the LP variants revealed that the mere substitution of an amino acid residue at position 107 in VP1 (Val to Leu) (LP9), position 33 in VP2 (Val to Ile) (LP14), or position 231 in VP3 (Ile to Thr) (LP8) was sufficient to restore the PV1/Mahoney phenotype. leucylproline 77-79 plasmalemma vesicle associated protein Mus musculus 305-308 11846457-5 2002 Fifty-three percent of patients had LP responses to HIV p24 antigen. leucylproline 36-38 transmembrane p24 trafficking protein 2 Homo sapiens 56-59 12351947-8 2002 LP in response to, HIV-1 p24 and gp160 was positive in responder patients. leucylproline 0-2 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 33-38 12089228-9 2002 p53-positive phenotype was associated with worse local control with LP (LCLP; 49% v 23%, P =.053) and inferior overall survival (OS; 51% v 29%, P =.017) at 5 years. leucylproline 68-70 tumor protein p53 Homo sapiens 0-3 11431695-9 2001 Ltap is expressed broadly in the neuroectoderm throughout early neurogenesis and is altered in two independent Lp alleles, identifying this gene as a strong candidate for Lp. leucylproline 111-113 VANGL planar cell polarity 2 Mus musculus 0-4 11431695-9 2001 Ltap is expressed broadly in the neuroectoderm throughout early neurogenesis and is altered in two independent Lp alleles, identifying this gene as a strong candidate for Lp. leucylproline 171-173 VANGL planar cell polarity 2 Mus musculus 0-4 11399297-6 2001 LP rams exposed to estrous ewes had more (P<.05) neurons staining positive for fos and fos-related antigens (FRA) in the mPOA and BNST than LP rams exposed to other rams or MO rams exposed to either estrous ewes or other rams. leucylproline 0-2 protein c-Fos Ovis aries 82-85 11346391-10 2001 CONCLUSIONS: For patients with better than LP vision, tap/biopsy is appropriate for those without diabetes. leucylproline 43-45 nuclear RNA export factor 1 Homo sapiens 54-57 11346391-12 2001 At present, initial vitrectomy or tap/biopsy are reasonable approaches for diabetic patients with better than LP vision. leucylproline 110-112 nuclear RNA export factor 1 Homo sapiens 34-37 11399297-6 2001 LP rams exposed to estrous ewes had more (P<.05) neurons staining positive for fos and fos-related antigens (FRA) in the mPOA and BNST than LP rams exposed to other rams or MO rams exposed to either estrous ewes or other rams. leucylproline 0-2 protein c-Fos Ovis aries 90-93 10862153-4 2000 These axon pathway defects are found in two other mutants with cephalic neural tube defects (NTD), loop-tail (Lp) and Pax3 (splotch; Sp(2H)). leucylproline 110-112 VANGL planar cell polarity 2 Mus musculus 99-108 11401449-1 2001 Loop-tail (Lp) is a semidominant mutation that affects neurulation in mice. leucylproline 11-13 VANGL planar cell polarity 2 Mus musculus 0-9 11401431-2 2001 Linkage analysis and physical mapping have previously localized the Lp locus to a region on mouse chromosome 1 defined by the markers D1Mit113-Tagln2. leucylproline 68-70 transgelin 2 Mus musculus 143-149 11401431-6 2001 The genes between Slam and Kiaa1355 are positional candidates for Lp. leucylproline 66-68 signaling lymphocytic activation molecule family member 1 Mus musculus 18-22 11166355-11 2001 An increase in MMP-2 activity per cell by LP cultures suggests that senescent keratocytes increase their degradative capacity. leucylproline 42-44 matrix metallopeptidase 2 Homo sapiens 15-20 11108266-4 2000 PSP94 is a small protein newly isolated from the rat prostate gland and demonstrates highly specific expression in the LP. leucylproline 119-121 microseminoprotein, beta Rattus norvegicus 0-5 11108266-5 2000 The results of in situ hybridization showed that PSP94, probasin, and SVSII were highly expressed in the intact LP. leucylproline 112-114 microseminoprotein, beta Rattus norvegicus 49-54 11108266-5 2000 The results of in situ hybridization showed that PSP94, probasin, and SVSII were highly expressed in the intact LP. leucylproline 112-114 probasin Rattus norvegicus 56-64 11108266-5 2000 The results of in situ hybridization showed that PSP94, probasin, and SVSII were highly expressed in the intact LP. leucylproline 112-114 semenogelin 1 Rattus norvegicus 70-75 9787141-7 1998 Detailed analysis of two LP samples showed that 65.8%, 4.4%, and 30.5% of CD34(+) cells express CCR-1, CCR-4, and CCR-5, respectively. leucylproline 25-27 CD34 molecule Homo sapiens 74-78 10836250-5 2000 Within the T-cell population, CD8+ cells decreased significantly from 63.0% in the LP phase to 54.2% in the LS phase (P = 0.04). leucylproline 83-85 CD8a molecule Homo sapiens 30-33 10441155-1 1999 In this study, the reversible conversion between the high- (HP) and low-potential (LP) forms of Cytb(559) has been analyzed in Tris-washed photosystem II (PSII) enriched membranes. leucylproline 83-85 mitochondrially encoded cytochrome b Homo sapiens 96-100 10051400-10 1999 The Lp interval, between D1Mit113 and Tagln2, can be spanned by two nonchimeric overlapping YACs that define a physical distance of approximately 1 Mb. leucylproline 4-6 transgelin 2 Mus musculus 38-44 10682819-8 2000 In addition, ADG and gain:feed ratio were greater (P < .03) for both 12.5% CP and supplemental LP. leucylproline 98-100 ADG Bos taurus 13-16 10591578-4 1999 The number of CK7-positive cells in the bile ductules was microscopically calculated within the 40-microm-thick interstitium along the limiting plate (LP), and the CK7-positive cell number per unit length of the LP was estimated. leucylproline 151-153 keratin 7 Homo sapiens 14-17 10192302-5 1999 In LP from BC patients, positive results were observed in 70% and 63% for CK19 and CEA RT-PCR, respectively. leucylproline 3-5 keratin 19 Homo sapiens 74-78 10192302-5 1999 In LP from BC patients, positive results were observed in 70% and 63% for CK19 and CEA RT-PCR, respectively. leucylproline 3-5 CEA cell adhesion molecule 3 Homo sapiens 83-86 10052826-10 1999 The intraoperative peak values of IL-6 in LP were significantly lower than those in the OP group (P < .01). leucylproline 42-44 interleukin 6 Homo sapiens 34-38 9933565-1 1999 The mouse looptail (Lp) mutation is an established model for neural tube defects with homozygous Lp embryos showing an open neural tube from the caudal midbrain to the tip of the tail. leucylproline 20-22 VANGL planar cell polarity 2 Mus musculus 10-18 9933565-3 1999 The Lp gene has been mapped to a 0.6-cM interval on mouse chromosome 1 delineated by two clusters of markers, Fcer1gamma/Usf1/D1Mit113/D1Wsu1 on the proximal side and Fcer1alpha/Spna1/D1Mit149 distally. leucylproline 4-6 upstream transcription factor 1 Mus musculus 121-125 9933565-3 1999 The Lp gene has been mapped to a 0.6-cM interval on mouse chromosome 1 delineated by two clusters of markers, Fcer1gamma/Usf1/D1Mit113/D1Wsu1 on the proximal side and Fcer1alpha/Spna1/D1Mit149 distally. leucylproline 4-6 Fc receptor, IgE, high affinity I, alpha polypeptide Mus musculus 167-177 9933565-3 1999 The Lp gene has been mapped to a 0.6-cM interval on mouse chromosome 1 delineated by two clusters of markers, Fcer1gamma/Usf1/D1Mit113/D1Wsu1 on the proximal side and Fcer1alpha/Spna1/D1Mit149 distally. leucylproline 4-6 spectrin alpha, erythrocytic 1 Mus musculus 178-183 9933565-6 1999 The combined analysis indicates that the 0.6-cM genetic interval for Lp corresponds to a minimal physical interval of 700 kb that is delineated by D1Mit113 proximally (two crossovers) and Fcer1alpha distally (one crossover). leucylproline 69-71 Fc receptor, IgE, high affinity I, alpha polypeptide Mus musculus 188-198 10079519-6 1999 Nhlh1 has been implicated previously as a candidate for the neural tube defect mutant loop-tail (Lp); here, we present sequence and expression data indicating that Nhlh1 is unlikely to be responsible for the Lp mutation. leucylproline 97-99 nescient helix loop helix 1 Mus musculus 0-5 10079519-6 1999 Nhlh1 has been implicated previously as a candidate for the neural tube defect mutant loop-tail (Lp); here, we present sequence and expression data indicating that Nhlh1 is unlikely to be responsible for the Lp mutation. leucylproline 97-99 VANGL planar cell polarity 2 Mus musculus 86-95 9787141-7 1998 Detailed analysis of two LP samples showed that 65.8%, 4.4%, and 30.5% of CD34(+) cells express CCR-1, CCR-4, and CCR-5, respectively. leucylproline 25-27 C-C motif chemokine receptor 1 Homo sapiens 96-101 9764725-7 1998 Suppression of LP responses by infectious Mmm (both strains) was restored in the presence of exogenous recombinant human interleukin-2 (rhIL-2). leucylproline 15-17 interleukin 2 Homo sapiens 121-134 9732191-5 1998 RESULTS: PSA levels showed a statistically significant increase 24 h after LP, then a slow decrease and by 1 month the PSA levels had returned to their initial levels. leucylproline 75-77 kallikrein related peptidase 3 Homo sapiens 9-12 9732191-6 1998 A statistically significant positive correlation was found between the PSA level 24 h after LP and the amount of energy applied to the prostate during operation (r 0.87, p < 0.0001). leucylproline 92-94 kallikrein related peptidase 3 Homo sapiens 71-74 9732191-9 1998 There was a statistically significant positive correlation between the reduction in PSA and the reduction in prostate weight 3 months after LP. leucylproline 140-142 kallikrein related peptidase 3 Homo sapiens 84-87 9732191-10 1998 CONCLUSION: This study showed that LP produced a variable rise in PSA, with a peak rise in PSA occurring 24 h after the procedure. leucylproline 35-37 kallikrein related peptidase 3 Homo sapiens 66-69 9732191-10 1998 CONCLUSION: This study showed that LP produced a variable rise in PSA, with a peak rise in PSA occurring 24 h after the procedure. leucylproline 35-37 kallikrein related peptidase 3 Homo sapiens 91-94 9732191-15 1998 This low level of PSA can probably indicate a reduction in prostate volume following LP. leucylproline 85-87 kallikrein related peptidase 3 Homo sapiens 18-21 9590656-10 1998 Small-scale filtrations of LP samples in the presence of trisodium citrate over columns with Ig-coated nylon wool resulted in removal of 96 +/- 4% of the monocytes and 74 +/- 18% of the myeloid cells, with a yield of 71 +/- 15% CD34+ cells and 67 +/- 10% granulocyte-monocyte colony-forming units (CFU-GM) (n=23). leucylproline 27-29 CD34 molecule Homo sapiens 228-232 9310006-10 1997 Chronic nightly CPAP therapy improved the reflex response of both LP (p < 0.001) and PG (p = 0.003) to nasal negative pressure application. leucylproline 66-68 centromere protein J Homo sapiens 16-20 9590656-5 1998 Filtration of LP samples over nylon wool in a medium containing fetal calf serum resulted in variable but on average low yields of CD34+ cells (48 +/- 30%; n=13) and strongly variable depletions of myeloid cells. leucylproline 14-16 CD34 molecule Homo sapiens 131-135 9749235-7 1998 Finally, the presence of LP was also related to the following biological abnormalities: GGT (p = 0.027), ASAT (p = 0.046), ALAT (p = 0.039). leucylproline 25-27 ATP binding cassette subfamily B member 7 Homo sapiens 105-109 9568745-3 1998 RESULTS: Fibrinogen was increased in all patients, and by each treatment category, when compared with the control group (421+/-143 all, 361+/-72 HD, 429+/-91 CAPD, 395+/-102 LP, 490+/-220 HP vs. 268+/-54 (N) mg/dl; P=0.0001) and correlated with urinary protein concentration, diastolic blood pressure and inversely with albumin. leucylproline 174-176 fibrinogen beta chain Homo sapiens 9-19 9553403-8 1998 LP were detected when two or three of following criteria"s had been registered: RMS 40 < 20 muV, t-QRS > 114ms, LPD > 38s. leucylproline 0-2 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 118-121 9708449-9 1998 As expected, a higher proportion of CD34+/cyclin A+/S/G2M cells was found in BM than in LP (p < 0.05). leucylproline 88-90 CD34 molecule Homo sapiens 36-40 9708449-9 1998 As expected, a higher proportion of CD34+/cyclin A+/S/G2M cells was found in BM than in LP (p < 0.05). leucylproline 88-90 cyclin A2 Homo sapiens 42-50 9708449-12 1998 The strongest association to the proliferative status was observed for CD49d, which was coexpressed by 85.9% +/-2.6% (BM) or 90.8%+/-2.5% (LP) of CD34+/S/G2M cells, whereas a distinct CD34+/CD49d-/S/G2M population could not be detected. leucylproline 139-141 integrin subunit alpha 4 Homo sapiens 71-76 9708449-12 1998 The strongest association to the proliferative status was observed for CD49d, which was coexpressed by 85.9% +/-2.6% (BM) or 90.8%+/-2.5% (LP) of CD34+/S/G2M cells, whereas a distinct CD34+/CD49d-/S/G2M population could not be detected. leucylproline 139-141 CD34 molecule Homo sapiens 146-150 9436938-2 1997 Therefore methods to reduce the tumor load of LP by CD34+ selection are envisaged. leucylproline 46-48 CD34 molecule Homo sapiens 52-56 9436938-9 1997 These results confirm that CD34+ selection can be considered for LP in MM. leucylproline 65-67 CD34 molecule Homo sapiens 27-31 9277513-5 1997 VEGF mRNA levels increased 60% in MP and 80% in LP above those in NP (P < 0.05) in uterine tissues; VEGF mRNA levels were also detectable in placentas and elevated approximately fivefold in LP vs. MP tissues (P < 0.01). leucylproline 48-50 vascular endothelial growth factor A Rattus norvegicus 0-4 9277513-5 1997 VEGF mRNA levels increased 60% in MP and 80% in LP above those in NP (P < 0.05) in uterine tissues; VEGF mRNA levels were also detectable in placentas and elevated approximately fivefold in LP vs. MP tissues (P < 0.01). leucylproline 193-195 vascular endothelial growth factor A Rattus norvegicus 0-4 9277513-5 1997 VEGF mRNA levels increased 60% in MP and 80% in LP above those in NP (P < 0.05) in uterine tissues; VEGF mRNA levels were also detectable in placentas and elevated approximately fivefold in LP vs. MP tissues (P < 0.01). leucylproline 193-195 vascular endothelial growth factor A Rattus norvegicus 103-107 9480176-9 1997 LP were detected when two or three of following criterias had been registered: RMS 40 < 20 microV, t-QRS > 114 ms, LPD > 38 s. There was no statistically significant differences in all time domain parameters of SAECG between records at the baseline and during ischemia in each study group. leucylproline 0-2 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 121-124