PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27032207-0	2016	Isoprene Side-chain of SMTP is Essential for Soluble Epoxide Hydrolase Inhibition and Cellular Localization.	isoprene	0-8	epoxide hydrolase 2	Homo sapiens	45-70
27032207-4	2016	Here, we investigate the yet-to-be-characterized function of the isoprene side- chain of SMTPs in sEH inhibition and cellular distribution.	isoprene	65-73	epoxide hydrolase 2	Homo sapiens	98-101
26008592-4	2015	These lanthanide complexes in combination with aluminum alkyls and [Ph3C](+)[B(C6F5)4](-) generated efficient homogeneous catalysts for the cis-1,4 polymerization of isoprene, with complex 1 having the best catalytic activity.	isoprene	166-174	suppressor of cytokine signaling 1	Homo sapiens	140-145
26335780-0	2015	Isoprene NO3 Oxidation Products from the RO2 + HO2 Pathway.	isoprene	0-8	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
26335780-2	2015	NO(3) adds preferentially to the C(1) position of isoprene (>6 times more favorably than addition to C(4)), followed by the addition of O(2) to produce a suite of nitrooxy alkylperoxy radicals (RO(2)).	isoprene	50-58	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	33-37
25010574-0	2014	Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism.	isoprene	30-38	LIM homeobox 1	Homo sapiens	113-117
25490879-0	2015	Dinuclear rare-earth metal alkyl complexes supported by indolyl ligands in mu-eta(2) :eta(1) :eta(1) hapticities and their high catalytic activity for isoprene 1,4-cis-polymerization.	isoprene	151-159	DNA polymerase iota	Homo sapiens	78-84
25490879-0	2015	Dinuclear rare-earth metal alkyl complexes supported by indolyl ligands in mu-eta(2) :eta(1) :eta(1) hapticities and their high catalytic activity for isoprene 1,4-cis-polymerization.	isoprene	151-159	secreted phosphoprotein 1	Homo sapiens	86-92
25490879-0	2015	Dinuclear rare-earth metal alkyl complexes supported by indolyl ligands in mu-eta(2) :eta(1) :eta(1) hapticities and their high catalytic activity for isoprene 1,4-cis-polymerization.	isoprene	151-159	secreted phosphoprotein 1	Homo sapiens	94-100
25434744-2	2015	Based on this result, the random and block copolymerization of myrcene and isoprene (IP) resulted in novel elastomers that comprise the amorphous iso-3,4-PMY and iso-3,4-PIP sequences.	isoprene	75-83	prolactin induced protein	Homo sapiens	170-173
25434744-2	2015	Based on this result, the random and block copolymerization of myrcene and isoprene (IP) resulted in novel elastomers that comprise the amorphous iso-3,4-PMY and iso-3,4-PIP sequences.	isoprene	85-87	prolactin induced protein	Homo sapiens	170-173
26044270-3	2015	This work presents the potential of isoprene as a novel dopant for NI-APPI.	isoprene	36-44	amyloid beta precursor protein	Homo sapiens	70-74
26044270-11	2015	Because in NI-APPI, thermal electrons, which are produced during the photoionization of a dopant, are considered the main reagent ions, both isoprene and toluene promoted the ionization of analytes through the same mechanisms, as expected.	isoprene	141-149	amyloid beta precursor protein	Homo sapiens	14-18
26044270-12	2015	CONCLUSIONS: Isoprene was shown to perform well as a novel dopant for NI-APPI.	isoprene	13-21	amyloid beta precursor protein	Homo sapiens	73-77
25010574-18	2014	Global modeling implementing LIM1 indicates that on average about 28% of the isoprene peroxys react via the 1,6-H-shift isomerization route, representing 100-150 Tg carbon per year.	isoprene	77-85	LIM homeobox 1	Homo sapiens	29-33
24004194-5	2013	The strong temperature dependence of F(MAE formation) helps to explain our observations of similar concentrations of IEPOX-derived organosulfates (IEPOX-OS; ~1 ng m(-3)) and MAE-derived organosulfates (MAE-OS; ~1 ng m(-3)) under cooler conditions (lower isoprene concentrations) and much higher IEPOX-OS (~20 ng m(-3)) relative to MAE-OS (<0.0005 ng m(-3)) at higher temperatures (higher isoprene concentrations).	isoprene	254-262	solute carrier family 6 member 1	Homo sapiens	39-42
25204462-6	2014	A significant increase in the catalase (CAT) and superoxide dismutase (SOD) activities was also observed by histaminase treatment in Isopren.-H2 and Isopren.-H3 groups.	isoprene	133-140	amine oxidase, copper containing 1	Rattus norvegicus	108-119
25204462-6	2014	A significant increase in the catalase (CAT) and superoxide dismutase (SOD) activities was also observed by histaminase treatment in Isopren.-H2 and Isopren.-H3 groups.	isoprene	149-156	amine oxidase, copper containing 1	Rattus norvegicus	108-119
24044877-3	2013	Additionally, the reactivities of Co(II) and Co(I) dppe complexes toward the Diels-Alder substrates isoprene and phenylacetylene were probed in gas-phase ion/molecule reactions (IMRs).	isoprene	100-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24044877-3	2013	Additionally, the reactivities of Co(II) and Co(I) dppe complexes toward the Diels-Alder substrates isoprene and phenylacetylene were probed in gas-phase ion/molecule reactions (IMRs).	isoprene	100-108	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	45-50
24044877-6	2013	Furthermore, the central intermediate of the solution-phase cobalt-catalyzed Diels-Alder reaction, [Co(I)(dppe)(isoprene)(phenylacetylene)](+), could be generated via IMR and examined in the gas phase.	isoprene	112-120	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	100-104
24582468-1	2014	Light-dependent de novo volatile isoprene emission by terrestrial plants (approximately 2% of carbon fixed during photosynthesis) contributes as much as 0.5 PgC/year to the global carbon cycle.	isoprene	33-41	progastricsin	Homo sapiens	157-160
23964958-7	2013	For reactions of Cl with 1,5-hexadiene, isoprene, and 2,3-dimethylbut-2-ene in CCl4, rate coefficients at 294 K are, respectively, (8.6 +- 0.8) x 10(9), (9.5 +- 1.6) x 10(9), and (1.7 +- 0.1) x 10(10) M(-1) s(-1).	isoprene	40-48	C-C motif chemokine ligand 4	Homo sapiens	79-83
24004194-5	2013	The strong temperature dependence of F(MAE formation) helps to explain our observations of similar concentrations of IEPOX-derived organosulfates (IEPOX-OS; ~1 ng m(-3)) and MAE-derived organosulfates (MAE-OS; ~1 ng m(-3)) under cooler conditions (lower isoprene concentrations) and much higher IEPOX-OS (~20 ng m(-3)) relative to MAE-OS (<0.0005 ng m(-3)) at higher temperatures (higher isoprene concentrations).	isoprene	391-399	solute carrier family 6 member 1	Homo sapiens	39-42
24004194-8	2013	In regions of high NOx, high isoprene emissions and strong vertical mixing the slower MPAN thermolysis rate aloft could increase the fraction of MPAN that forms MAE resulting in a vertically varying isoprene SOA source.	isoprene	199-207	solute carrier family 6 member 1	Homo sapiens	161-164
24020856-6	2013	The measurement results of K(H) values for isoprene, limonene, alpha-pinene, and linalool at 298 K were 0.036 +- 0.003; 0.048 +- 0.004; 0.029 +- 0.004; and 21.20 +- 0.30 mol L(-1) atm(-1), respectively.	isoprene	43-51	immunoglobulin kappa variable 1-16	Homo sapiens	174-186
23867846-7	2013	The large HO2/OH ratios from the CMAQ model simulations with the GEIA biogenic emission were possibly due to the overestimation of GEIA biogenic isoprene emissions over East Asia.	isoprene	145-153	heme oxygenase 2	Homo sapiens	10-13
23458186-0	2013	Bis(oxazolinyl)phenyl-ligated rare-earth-metal complexes: highly regioselective catalysts for cis-1,4-polymerization of isoprene.	isoprene	120-128	cytokine inducible SH2 containing protein	Homo sapiens	94-99
23553832-7	2013	Field measurements taken in Chapel Hill, North Carolina, considered along with the modeling results indicate the atmospheric significance and relevance of MAE chemistry across the United States, especially in urban areas heavily impacted by isoprene emissions.	isoprene	241-249	solute carrier family 6 member 1	Homo sapiens	155-158
23553832-8	2013	Identification of MAE implies a major role of atmospheric epoxides in forming SOA from isoprene photooxidation.	isoprene	87-95	solute carrier family 6 member 1	Homo sapiens	18-21
23553832-9	2013	Updating current atmospheric modeling frameworks with MAE chemistry could improve the way that SOA has been attributed to isoprene based on ambient tracer measurements, and lead to SOA parameterizations that better capture the dependency of yield on NO(x).	isoprene	122-130	solute carrier family 6 member 1	Homo sapiens	54-57
23458186-5	2013	Upon activation with [PhNHMe2][B(C6F5)4] and Al(i)Bu3, complexes 2-5 exhibited highly catalytic activities and more than 98% cis-1,4-selectivity for isoprene polymerization while complexes 1 and 6 were inactive for this reaction.	isoprene	149-157	cytokine inducible SH2 containing protein	Homo sapiens	125-130
23458186-6	2013	When use of the catalyst system consisted of complex 2, [PhNHMe2][B(C6F5)4], and Al(i)Bu3 for isoprene polymerization, the resultant polymer has a high cis-1,4-selectivity up to 99.5%.	isoprene	94-102	cytokine inducible SH2 containing protein	Homo sapiens	152-157
21614390-1	2011	Electron-rich aryl ethers and phenols react with isoprene (2-methylbuta-1,3-diene) in the presence of catalytic Bi(OTf)(3) at 40  C to afford the corresponding prenylated or 2,2-dimethylchroman products, respectively, in moderate to good yields.	isoprene	49-57	POU class 5 homeobox 1	Homo sapiens	102-121
23126257-5	2013	When expressed in Escherichia coli, SlSPS and SlDPS extend the prenyl chain length of the endogenous ubiquinone to nine and ten isoprene units respectively.	isoprene	128-136	sucrose-phosphate synthase	Solanum lycopersicum	36-41
22886209-13	2012	Atorvastatin inhibition of periostin expression induced by TGF-beta1 in VSMCs may be exerted by inhibition of the production of MVA and other isoprene compounds and by blocking the Rho/Rho kinase signaling pathway.	isoprene	142-150	periostin	Rattus norvegicus	27-36
21614390-1	2011	Electron-rich aryl ethers and phenols react with isoprene (2-methylbuta-1,3-diene) in the presence of catalytic Bi(OTf)(3) at 40  C to afford the corresponding prenylated or 2,2-dimethylchroman products, respectively, in moderate to good yields.	isoprene	59-81	POU class 5 homeobox 1	Homo sapiens	102-121
21548641-6	2011	In rodents, isoprene-induced tumors show unique point mutations (A T transversions) in the K-ras protooncogene at codon 61.	isoprene	12-20	KRAS proto-oncogene, GTPase	Homo sapiens	91-96
20593767-1	2010	The type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2) catalyzes the reversible isomerization of the two ubiquitous isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are required to initiate the biosynthesis of all isoprenoid compounds found in nature.	isoprene	141-149	isopentenyl-diphosphate delta isomerase 2	Homo sapiens	73-78
21425920-1	2011	Defects in mevalonate kinase, a critical rate-limiting enzyme in cholesterol and isoprene metabolism, have been associated with 2 clinical phenotypes: mevalonic aciduria, which presents in infancy or early childhood with growth failure, dysmorphic features, and neurologic disease; and hyperimmunoglobulinemia D and periodic fever syndrome, which usually presents outside the neonatal period as an autoinflammatory periodic fever syndrome.	isoprene	81-89	mevalonate kinase	Homo sapiens	11-28
20701322-3	2010	We have used RRKM/master equation and variational transition state theory calculations to quantify the competition between unimolecular isomerization and bimolecular hydration reactions for the syn and anti acetaldehyde oxide formed in trans-2-butene ozonolysis and for the CIs formed in isoprene ozonolysis possessing syn-methyl groups.	isoprene	288-296	synemin	Homo sapiens	194-197
21321731-0	2011	Rare earth metal bis(amide) complexes bearing amidinate ancillary ligands: synthesis, characterization, and performance as catalyst precursors for cis-1,4 selective polymerization of isoprene.	isoprene	183-191	suppressor of cytokine signaling 1	Homo sapiens	147-152
21321731-5	2011	In the presence of AlMe(3), and in combination with one equimolar amount of [Ph(3)C][B(C(6)F(5))(4)], complexes 1 and 2 showed high activity towards isoprene polymerization to give high molecular weight polyisoprene (M(n) > 10(4)) with good cis-1,4 selectivity (>90%).	isoprene	149-157	suppressor of cytokine signaling 1	Homo sapiens	244-249
21383461-7	2009	Characteristic (median) values for breath isoprene concentration and molar flow, i.e., the amount of isoprene exhaled per minute are 100 ppb and 29 nmol min(-1), respectively, with some intra-individual day-to-day variation.	isoprene	42-50	CD59 molecule (CD59 blood group)	Homo sapiens	153-159
20121059-1	2010	We report the first isomeric-selective study of the dominant isomeric pathway in the OH-initiated oxidation of isoprene in the presence of O2 and NO using the laser photolysis-laser induced fluorescence (LP-LIF) technique.	isoprene	111-119	LIF interleukin 6 family cytokine	Homo sapiens	207-210
21383461-7	2009	Characteristic (median) values for breath isoprene concentration and molar flow, i.e., the amount of isoprene exhaled per minute are 100 ppb and 29 nmol min(-1), respectively, with some intra-individual day-to-day variation.	isoprene	101-109	CD59 molecule (CD59 blood group)	Homo sapiens	153-159
18463892-7	2008	Rab proteins must not only be bound to GTP, but they need also to be "prenylated"-i.e. bound to the cell membranes by isoprenes, which are intermediaries in the synthesis of cholesterol (e.g. geranyl geranyl or farnesyl compounds).	isoprene	118-127	ArfGAP with FG repeats 1	Homo sapiens	0-3
17274086-0	2007	Cationic alkyl rare-earth metal complexes bearing an ancillary bis(phosphinophenyl)amido ligand: a catalytic system for living cis-1,4-polymerization and copolymerization of isoprene and butadiene.	isoprene	174-182	suppressor of cytokine signaling 1	Homo sapiens	127-132
18338895-3	2008	Complexes 1-6, 9-11, and 13 combined with aluminum tris(alkyl)s and [Ph3C][B(C6F5)4] established a homogeneous Ziegler-Natta catalyst system, which exhibited high activities and excellent cis-1,4 selectivities for the polymerizations of butadiene (T(p) = 25 degrees C, 99.9%; 0 degrees C, 100%) and isoprene (T(p) = 25 degrees C, 98.8%).	isoprene	299-307	cytokine inducible SH2 containing protein	Homo sapiens	188-193
17955139-4	2007	Upon activation with [PhMe(2)NH][B(C(6)F(5))(4)] the monophosphacyclopentadienyl complexes initiate the polymerization of isoprene producing 1,4-trans-polyisoprene (tPIP > 87%) with moderate activity (approximately 30 kg(PIP) mol(Ln)(-1) h(-1)).	isoprene	122-130	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	Homo sapiens	165-169
17955139-4	2007	Upon activation with [PhMe(2)NH][B(C(6)F(5))(4)] the monophosphacyclopentadienyl complexes initiate the polymerization of isoprene producing 1,4-trans-polyisoprene (tPIP > 87%) with moderate activity (approximately 30 kg(PIP) mol(Ln)(-1) h(-1)).	isoprene	122-130	prolactin induced protein	Homo sapiens	166-169
17298042-6	2007	On the basis of this SAR, it is possible to predict the site-specific rate constants for (poly)alkene + OH reactions accurately, including larger biogenic compounds such as isoprene and terpenes.	isoprene	173-181	sarcosine dehydrogenase	Homo sapiens	21-24
16802822-3	2006	The reaction proceeds smoothly at room temperature in the absence of any phosphane or nitrogen ligands and is highly regioselective and stereoselective for a wide variety combination of aldehydes and 1,3-dienes: e.g., isoprene and benzaldehyde combine to give a mixture of anti- and syn-1-phenyl-3-methyl-4-penten-1-ol (2.2) in a ratio of 15:1 in 90% yield.	isoprene	218-226	synapsin I	Homo sapiens	283-288
16899082-6	2006	Maintenance of the CCA1/LHY-TOC1 molecular oscillator at these temperatures in oil palm allows for the possibility that this system is involved in the control of isoprene emission rhythms.	isoprene	162-170	circadian clock associated 1	Arabidopsis thaliana	19-23
16899082-6	2006	Maintenance of the CCA1/LHY-TOC1 molecular oscillator at these temperatures in oil palm allows for the possibility that this system is involved in the control of isoprene emission rhythms.	isoprene	162-170	Homeodomain-like superfamily protein	Arabidopsis thaliana	24-27
15827619-3	2005	The products of the Rer2 and Srt1 proteins consist of 14-17 and 18-23 isoprene units, respectively.	isoprene	70-78	ditrans,polycis-polyprenyl diphosphate synthase	Saccharomyces cerevisiae S288C	20-24
15946942-3	2005	In this study, we developed a variety of substrates and inhibitors of Icmt that vary in the isoprene moiety in order to gain information about the nature of the lipophilic substrate binding site.	isoprene	92-100	isoprenylcysteine carboxyl methyltransferase	Homo sapiens	70-74
15827619-3	2005	The products of the Rer2 and Srt1 proteins consist of 14-17 and 18-23 isoprene units, respectively.	isoprene	70-78	ditrans,polycis-polyprenyl diphosphate synthase	Saccharomyces cerevisiae S288C	29-33
14711309-7	2004	Since bisphosphonates are known to be potent, nanomolar inhibitors of the mevalonate/isoprene pathway enzyme farnesyl pyrophosphate synthase (FPPS), we also compared the pharmacophores for gammadelta T cell activation with those for FPPS inhibition, using the Catalyst program.	isoprene	85-93	farnesyl diphosphate synthase	Homo sapiens	109-140
15900749-3	2005	The results also showed that the emissions of isoprene were affected by both temperature and PAR(Photosynthetic Active Radiation), while monoterpene emissions were mainly temperature-dependent.	isoprene	46-54	jumping translocation breakpoint	Homo sapiens	93-96
14711309-7	2004	Since bisphosphonates are known to be potent, nanomolar inhibitors of the mevalonate/isoprene pathway enzyme farnesyl pyrophosphate synthase (FPPS), we also compared the pharmacophores for gammadelta T cell activation with those for FPPS inhibition, using the Catalyst program.	isoprene	85-93	farnesyl diphosphate synthase	Homo sapiens	142-146
12270134-4	2002	Ubiquinols inhibited the nSMase more efficiently than ubiquinones, and hydrophobic homologs with six or nine isoprene units were the most effective inhibitors.	isoprene	109-117	sphingomyelin phosphodiesterase 2	Homo sapiens	25-31
12667062-6	2003	Crystallographic analysis of one of these analogues bound to PFTase reveals that the diphosphate moiety and the two isoprene units bind in the same positions occupied by the corresponding atoms in FPP when bound to PFTase.	isoprene	116-124	protein farnesyltransferase	Saccharomyces cerevisiae S288C	61-67
12667062-6	2003	Crystallographic analysis of one of these analogues bound to PFTase reveals that the diphosphate moiety and the two isoprene units bind in the same positions occupied by the corresponding atoms in FPP when bound to PFTase.	isoprene	116-124	protein farnesyltransferase	Saccharomyces cerevisiae S288C	215-221
12667062-8	2003	Crystallographic analysis of geranylgeranyl diphosphate bound to PFTase shows that the terminal two isoprene units and diphosphate group of the molecule map to the corresponding atoms in FPP; however, the first and second isoprene units bulge away from the acceptor protein binding site.	isoprene	100-108	protein farnesyltransferase	Saccharomyces cerevisiae S288C	65-71
12667062-8	2003	Crystallographic analysis of geranylgeranyl diphosphate bound to PFTase shows that the terminal two isoprene units and diphosphate group of the molecule map to the corresponding atoms in FPP; however, the first and second isoprene units bulge away from the acceptor protein binding site.	isoprene	222-230	protein farnesyltransferase	Saccharomyces cerevisiae S288C	65-71
11513579-4	2001	Using the two-hybrid system, we show that nonprenylated Rac1 interacts very weakly with Rho-GDI, pointing to the predominant role of protein-isoprene interaction in complex formation.	isoprene	141-149	Rac family small GTPase 1	Homo sapiens	56-60
12027654-1	2002	[reaction: see text] Prenyl (3-methylbut-2-enyl) ester is catalytically cleaved by TMS triflate affording carboxylic acid and isoprene in high yield under mild conditions with high chemoselectivity without causing epimerization of the neighboring chiral center.	isoprene	126-134	PYD and CARD domain containing	Homo sapiens	83-86
11535090-2	2001	B3LYP/6-31G energies of the transition structures for the reactions of dimethylvinylborane and vinyl-9-BBN with trans-piperylene and isoprene yielded calculated ratios which are in very good agreement with experimental values.	isoprene	133-141	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	2-5
11018290-2	2000	The yeast Saccharomyces cerevisiae strain LB332 bearing a mutation in the ERG20 gene encoding farnesyl diphosphate synthase (FPPS) synthesizes significantly longer dolichols than the wild type strain FL100 (14-31 and 14-19 isoprene units, respectively).	isoprene	223-231	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	74-79
11511427-12	2001	RESULTS: Breath isoprene production in subjects with CHF was significantly reduced compared to controls 83(23) vs. 168(20) pmol min(-1) kg(-1).	isoprene	16-24	CD59 molecule (CD59 blood group)	Homo sapiens	128-134
11132142-1	2000	Gas phase ozonolysis reactions of the alkenes ethene, cis- and trans-but-2-ene, isoprene and the monoterpenes alpha-pinene, beta-pinene, beta-carene, limonene and beta-myrcene have been carried out and the reaction products have been trapped in O2-doped-argon matrices onto a Csl window held at 12 K. Products have been identified by IR spectroscopy.	isoprene	80-88	chorionic somatomammotropin hormone like 1	Homo sapiens	276-279
10223196-12	1999	The chloroprene-induced ras mutation spectra was similar to that seen with isoprene, where the predominant base change was an A-->T transversion at K-ras codon 61.	isoprene	75-83	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	151-156
10798620-9	2000	AtRhoGDI1 encodes a 22.5 kDa protein which contains highly conserved amino acids in the isoprene binding pocket and exhibits 29% to 37% similarity to known mammalian RhoGDI homologues.	isoprene	88-96	Rho GDP dissociation inhibitor alpha	Homo sapiens	2-8
10401001-0	1999	Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis.	isoprene	138-146	mevalonate kinase	Homo sapiens	73-90
9060168-1	1997	Radical anions and cations of the biologically important coenzymes Q-6 and Q-10, which have 6 and 10 unsaturated isoprene units in their side chains, respectively, have been generated in various solvents, and the results compared with those obtained for Q-0, a ubiquinone with no isoprene units, and for decylubiquinone Q-2 which has a saturated side chain.	isoprene	113-121	quiescin sulfhydryl oxidase 1	Homo sapiens	67-70
9392419-0	1997	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.	isoprene	101-109	mevalonate kinase	Homo sapiens	33-50
9392419-7	1997	These results provide additional evidence that MKase may occupy a central regulatory role in the control of cholesterol and nonsterol isoprene biosynthesis.	isoprene	134-142	mevalonate kinase	Homo sapiens	47-52
9111215-0	1997	Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.	isoprene	121-129	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	5-10
9111215-0	1997	Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.	isoprene	121-129	Harvey rat sarcoma virus oncogene	Mus musculus	15-20
9111215-6	1997	A higher frequency of ras mutations, in particular K-ras mutations, was detected in isoprene-induced neoplasms than in 1,3-butadiene-induced or control HG neoplasms.	isoprene	84-92	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	51-56
9111215-7	1997	All of the isoprene-induced HG neoplasms exhibited activated K-ras (60%) or H-ras (40%) mutations.	isoprene	11-19	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	61-66
9111215-7	1997	All of the isoprene-induced HG neoplasms exhibited activated K-ras (60%) or H-ras (40%) mutations.	isoprene	11-19	Harvey rat sarcoma virus oncogene	Mus musculus	76-81
9111215-9	1997	The predominant mutations in isoprene-induced HG neoplasms, but not in previously or newly analysed 1,3-butadiene-induced HG neoplasms, consisted of A-->T transversions (CAA-->CTA) at K-ras codon 61 (15/30) and C-->A transversions (CAA-->AAA) at H-ras codon 61 (8/30).	isoprene	29-37	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	190-195
9111215-9	1997	The predominant mutations in isoprene-induced HG neoplasms, but not in previously or newly analysed 1,3-butadiene-induced HG neoplasms, consisted of A-->T transversions (CAA-->CTA) at K-ras codon 61 (15/30) and C-->A transversions (CAA-->AAA) at H-ras codon 61 (8/30).	isoprene	29-37	Harvey rat sarcoma virus oncogene	Mus musculus	258-263
9111215-11	1997	Isoprene-induced HG neoplasms with K-ras or H-ras mutations had an elevated proliferating cell nuclear antigen (PCNA) index, compared to spontaneous HG neoplasms without ras mutations.	isoprene	0-8	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	35-40
9111215-11	1997	Isoprene-induced HG neoplasms with K-ras or H-ras mutations had an elevated proliferating cell nuclear antigen (PCNA) index, compared to spontaneous HG neoplasms without ras mutations.	isoprene	0-8	Harvey rat sarcoma virus oncogene	Mus musculus	44-49
9111215-11	1997	Isoprene-induced HG neoplasms with K-ras or H-ras mutations had an elevated proliferating cell nuclear antigen (PCNA) index, compared to spontaneous HG neoplasms without ras mutations.	isoprene	0-8	proliferating cell nuclear antigen	Mus musculus	76-110
9111215-11	1997	Isoprene-induced HG neoplasms with K-ras or H-ras mutations had an elevated proliferating cell nuclear antigen (PCNA) index, compared to spontaneous HG neoplasms without ras mutations.	isoprene	0-8	proliferating cell nuclear antigen	Mus musculus	112-116
9461254-10	1998	We interpret these results to mean that dihydroprenyl phosphates with more than seven isoprene units have apoptosis-inducing activity and that their signal is mediated by caspase-3-like activation.	isoprene	86-94	caspase 3	Homo sapiens	171-180
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-107
9021169-9	1996	Isoprene (monoepoxide) metabolism sowed a significant correlation with CYP2E1 activity, determined as chlorzoxazone 6-hydroxylation.	isoprene	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
9021169-10	1996	CYP2E1 is therefore the major enzyme involved in hepatic metabolism of isoprene and the isoprene monoepoxides in vitro.	isoprene	71-79	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	117-123
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	125-131
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	133-139
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	141-147
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	149-155
9021169-1	1996	The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4.	isoprene	18-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	160-166
9021169-4	1996	CYP2E1 was the only enzyme showing detectable formation of the diepoxide of isoprene, 2-methyl-1,2:3,4-diepoxybutane.	isoprene	76-84	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
1377680-1	1992	Mevalonic aciduria is the first proposed inherited disorder of the cholesterol/isoprene biosynthetic pathway in humans, and it is presumed to be caused by a mutation in the gene coding for mevalonate kinase.	isoprene	79-87	mevalonate kinase	Homo sapiens	189-206
8474436-1	1993	Squalene synthetase (farnesyl diphosphate:farnesyl diphosphate farnesyltransferase; EC 2.5.1.21) is thought to represent a major control point of isoprene and sterol biosynthesis in eukaryotes.	isoprene	146-154	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-19
12232201-0	1994	Isoprene Emission from Velvet Bean Leaves (Interactions among Nitrogen Availability, Growth Photon Flux Density, and Leaf Development).	isoprene	0-8	brain expressed associated with NEDD4 1	Homo sapiens	30-34
8276863-5	1994	In the current study, inhibitors of the isoprene biosynthetic pathway were used to define further this mevalonic acid derivative involved in the accelerated degradation of HMG-CoA reductase.	isoprene	40-48	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	172-189
8499655-2	1993	We report here the chromosomal mapping of nine loci in the mouse that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and nonsterol branches of the isoprene biosynthetic pathway.	isoprene	272-280	farnesyl diphosphate synthetase	Mus musculus	107-140
34438153-3	2021	In this work, we comprehensively investigated the reaction mechanism of isoprene with Cl using quantum chemistry calculation, and first elaborated the specific reaction mechanisms of chloroalkenyl peroxy radicals with HO2/NO and the formation of 2-methylbut-3-enal, highlighting their important roles in the SOA formation.	isoprene	72-80	heme oxygenase 2	Homo sapiens	218-224
16668365-0	1991	Delayed Onset of Isoprene Emission in Developing Velvet Bean (Mucuna sp.)	isoprene	17-25	brain expressed associated with NEDD4 1	Homo sapiens	56-60
16668365-4	1991	(velvet bean) is an isoprene emitter, and leaf isoprene emission rate increased as much as 125-fold as leaves developed, and declined in older leaves.	isoprene	20-28	brain expressed associated with NEDD4 1	Homo sapiens	8-12
16668365-4	1991	(velvet bean) is an isoprene emitter, and leaf isoprene emission rate increased as much as 125-fold as leaves developed, and declined in older leaves.	isoprene	47-55	brain expressed associated with NEDD4 1	Homo sapiens	8-12
34438153-5	2021	Following the initial reactions, their subsequent reactions with O2 and HO2 (or NO) under different atmospheric conditions could lead to the formation of 17 highly oxidized molecules (HOMs), of which P10, P12, P16, P17, P19 and P33 generated by the subsequent reactions of the major first-generation products (MVK, CMBO, CMBA and MBO) have been detected in the reaction process of isoprene with Cl in the chamber experiment.	isoprene	381-389	mevalonate kinase	Homo sapiens	310-313
34204568-6	2021	The degradation of rubber first takes place when lcp enzyme cleaves the isoprene double bond, breaking them down into the sole carbon and energy source to be utilized by the bacteria.	isoprene	72-80	kelch domain containing 2	Homo sapiens	49-52
34742186-1	2021	The electronic spectrum of methyl vinyl ketone oxide (MVK-oxide), a four-carbon Criegee intermediate derived from isoprene ozonolysis, is examined on its second pi*   pi transition, involving primarily the vinyl group, at UV wavelengths (lambda) below 300 nm.	isoprene	114-122	mevalonate kinase	Homo sapiens	54-57
34885764-3	2021	The deletion of alcohol dehydrogenase (adhE) and acetate kinase (ackA) genes, along with the supplementation with betaine, improved the co-production of lactate and isoprene from the substrates of glucose and mevalonate.	isoprene	165-173	Alcohol dehydrogenase	Escherichia coli	16-37
34885764-3	2021	The deletion of alcohol dehydrogenase (adhE) and acetate kinase (ackA) genes, along with the supplementation with betaine, improved the co-production of lactate and isoprene from the substrates of glucose and mevalonate.	isoprene	165-173	Alcohol dehydrogenase	Escherichia coli	39-43
34494036-7	2021	According to the ME simulations, without any adjustment to energies, the most important and second most important product channels at the high temperatures are isoprene + HO2 (yield > 91%) and (2R/S)-3-methyl-1,2-epoxybut-3-ene + OH (yield < 8%).	isoprene	160-168	heme oxygenase 2	Homo sapiens	171-174
34577927-0	2021	Effect of the Epoxide Contents of Liquid Isoprene Rubber as a Processing Aid on the Properties of Silica-Filled Natural Rubber Compounds.	isoprene	41-49	activation induced cytidine deaminase	Homo sapiens	73-76
34577927-1	2021	In this study, we examined the feasibility of using epoxidized liquid isoprene rubber (E-LqIR) as a processing aid for truck and bus radial (TBR) tire treads and investigated the effects of the epoxide content on the wear resistance, fuel efficiency, and resistance to extraction of the E-LqIRs.	isoprene	70-78	activation induced cytidine deaminase	Homo sapiens	111-114
34065491-6	2021	The results are compared to analogous studies on the reaction of formic acid with methyl vinyl ketone oxide (MVK-oxide), the other four-carbon Criegee intermediate in isoprene ozonolysis.	isoprene	167-175	mevalonate kinase	Homo sapiens	109-112
35306372-3	2022	Photochemical oxidation of isoprene leads to the formation of hydroperoxides, environmental oxidants that lead to inflammatory (IL-8) and adaptive (HMOX1) gene expression in human airway epithelial cells (HAEC).	isoprene	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
35568171-8	2022	Methyl vinyl ketone and methacrolein (MVK + MACR) exhibited contributions from both secondary photooxidation of isoprene and direct emissions from traffic.	isoprene	112-120	mevalonate kinase	Homo sapiens	38-41
35581680-4	2022	Terminating a living cis -1,4-selective isoprene polymerization by isocyanate as cross-linker ( CL ), star polyisoprene with low polydispersity was obtained at high yield (91.8%).	isoprene	40-48	suppressor of cytokine signaling 1	Homo sapiens	21-27
35157860-3	2022	In this study, we aimed to investigate the spatio-temporal variability and atmospheric impacts of biogenic and anthropogenic isoprene in the subtropical megacity of Sao Paulo (MASP), Brazil.	isoprene	125-133	MBL associated serine protease 1	Homo sapiens	176-180
35306372-3	2022	Photochemical oxidation of isoprene leads to the formation of hydroperoxides, environmental oxidants that lead to inflammatory (IL-8) and adaptive (HMOX1) gene expression in human airway epithelial cells (HAEC).	isoprene	27-35	heme oxygenase 1	Homo sapiens	148-153
35099100-2	2022	It was found that methylenecyclobutane hydrogenation leads to formation of a mixture of reaction products including cyclic (1-methylcyclobutene, methylcyclobutane), linear (1-pentene, cis-2-pentene, trans-2-pentene, pentane) and branched (isoprene, 2-methyl-1-butene, 2-methyl-2-butene, isopentane) compounds.	isoprene	239-247	suppressor of cytokine signaling 2	Homo sapiens	184-189
35557766-4	2022	Our results provide the first direct, time-resolved, experimental validation of the theory-based Leuven Isoprene Mechanism (LIM1), based on isomerization of isoprene-RO2 radicals and OH regeneration, that partially accounts for model:measurement divergence in OH.	isoprene	157-165	LIM homeobox 1	Homo sapiens	124-128
35229374-1	2022	Terpenes are one of the most abundant classes of secondary metabolites produced by plants and can be divided based on the number of isoprene units (C5 ) in monoterpenes (2 units-C10 ), sesquiterpenes (3 units-C15 ), diterpenes (4 units-C20 ), triterpenes (6 units-C30 ), etc.	isoprene	132-140	homeobox C10	Homo sapiens	178-181
35063553-6	2022	A correlation of SOA tracers with temperature implies that the isoprene and alpha/beta-pinene SOA tracers in summer were greatly boosted by plant emissions and the high DHOPA in summer could be attributed to evaporation of paint and solvent.	isoprene	63-71	amyloid beta precursor protein	Homo sapiens	0-1
35063553-8	2022	Furthermore, we observed a close correlation of summer isoprene and alpha/beta-pinene SOA tracers with sulfate only in Shanghai, which verifies that biogenic SOA formation was facilitated by high concentration of sulfate.	isoprene	55-63	amyloid beta precursor protein	Homo sapiens	25-26
2569235-4	1989	Studies of yeast mutants blocked in sterol biosynthesis demonstrated that the membrane association and biological activation of the yeast Ras2 protein require mevalonate, a precursor of sterols and other isoprenes such as farnesyl pyrophosphate.	isoprene	204-213	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	138-142
2777796-8	1989	The data indicate that products of HMG-CoA reductase (isoprenes, cholesterol and/or cholesterol metabolites) are required along with stimulators of protein kinases A and C, to regulate ovarian granulosa cell apoE production.	isoprene	54-63	apolipoprotein E	Rattus norvegicus	208-212
2613235-2	1989	Somatic cell hybrid studies and in situ hybridization show that the human genome contains five distinct loci that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and the nonsterol branches of the isoprene biosynthetic pathway.	isoprene	320-328	farnesyl diphosphate synthase	Homo sapiens	151-184
2613235-2	1989	Somatic cell hybrid studies and in situ hybridization show that the human genome contains five distinct loci that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and the nonsterol branches of the isoprene biosynthetic pathway.	isoprene	320-328	farnesyl diphosphate synthase	Homo sapiens	186-189
4712055-0	1973	[Effect of chemical substances isolated from isoprene rubber SKI-3].	isoprene	45-53	tetratricopeptide repeat domain 37	Homo sapiens	61-66
2535541-2	1989	The HMGR reaction makes mevalonate, a necessary component in the synthesis of all isoprene containing compounds, such as sterols and carotenoids.	isoprene	82-90	3-hydroxy-3-methylglutaryl-coenzyme A reductase 2	Solanum lycopersicum	4-8
33881099-7	2021	Upon activation with Al2Et3Cl3 in toluene, these complexes showed high activities in isoprene polymerization affording cis-1,4 enriched polymers with a moderate molecular weight (0.85-4.72 x 104 Da).	isoprene	85-93	suppressor of cytokine signaling 1	Homo sapiens	119-124
5639923-5	1968	The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.	isoprene	173-181	complement C3	Homo sapiens	59-62
33650589-5	2021	The theoretical predictions are implemented in the FZJ-NO3-isoprene mechanism for NO3-initiated atmospheric oxidation of isoprene.	isoprene	59-67	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
33662067-7	2021	Since isoprene is the most abundant hydrocarbon emitted into the atmosphere, and isoprene epoxydiols are the most important isoprene secondary organic aerosol precursors, our laboratory findings can aid in quantifying the direct radiative forcing of sulfates in the presence of organic compounds, thus more clearly resolving the impact of such aerosol particles on the Earth"s climate.	isoprene	6-14	activation induced cytidine deaminase	Homo sapiens	199-202
33662067-7	2021	Since isoprene is the most abundant hydrocarbon emitted into the atmosphere, and isoprene epoxydiols are the most important isoprene secondary organic aerosol precursors, our laboratory findings can aid in quantifying the direct radiative forcing of sulfates in the presence of organic compounds, thus more clearly resolving the impact of such aerosol particles on the Earth"s climate.	isoprene	81-89	activation induced cytidine deaminase	Homo sapiens	199-202
33650589-0	2021	Theoretical and experimental study of peroxy and alkoxy radicals in the NO3-initiated oxidation of isoprene.	isoprene	99-107	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
33650589-1	2021	The initial stages of the nitrate radical (NO3) initiated oxidation of isoprene, in particular the fate of the peroxy (RO2) and alkoxy (RO) radicals, are examined by an extensive set of quantum chemical and theoretical kinetic calculations.	isoprene	71-79	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
33889791-0	2021	Gas-Particle Partitioning and SOA Yields of Organonitrate Products from NO3-Initiated Oxidation of Isoprene under Varied Chemical Regimes.	isoprene	99-107	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
33650589-5	2021	The theoretical predictions are implemented in the FZJ-NO3-isoprene mechanism for NO3-initiated atmospheric oxidation of isoprene.	isoprene	59-67	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
33444001-4	2021	Upon activation by [Ph3C][B(C6F5)4], 1-Y and 2-Lu could catalyze the living polymerization of isoprene and beta-myrcene with high catalytic activity and high cis-1,4-selectivity (up to 92.3% for isoprene and 98.5% for beta-myrcene).	isoprene	94-102	suppressor of cytokine signaling 1	Homo sapiens	158-163
33411859-2	2021	Upon activation by [Ph3C][B(C6F5)4], the scandium (P-Sc and S-Sc) and yttrium complexes (P-Y and S-Y) could catalyze the polymerization of isoprene with cis-1,4 selectivity (up to 98.8%), while the lutetium analogues P-Lu and S-Lu produced trans-1,4 selective polyisoprene (up to 83.3%).	isoprene	139-147	suppressor of cytokine signaling 1	Homo sapiens	153-158
33444001-4	2021	Upon activation by [Ph3C][B(C6F5)4], 1-Y and 2-Lu could catalyze the living polymerization of isoprene and beta-myrcene with high catalytic activity and high cis-1,4-selectivity (up to 92.3% for isoprene and 98.5% for beta-myrcene).	isoprene	195-203	suppressor of cytokine signaling 1	Homo sapiens	158-163
33444001-5	2021	Moreover, the 1-Y/[Ph3C][B(C6F5)4] catalytic system also could promote the polymerization of butadiene and its copolymerization with isoprene to produce copolymers with high cis-1,4-selectivity and narrow polydispersity.	isoprene	133-141	suppressor of cytokine signaling 1	Homo sapiens	174-179
33396196-11	2020	CONCLUSIONS: Acetone, isoprene, and propionaldehyde appear in breath and oxygenator outflow gas in comparable amounts.	isoprene	22-30	gastrin	Homo sapiens	92-95
33301299-9	2021	Isoprene emission rates increased linearly with salivary alpha-amylase levels (r2 = 0.6, p = 0.02).	isoprene	0-8	amylase alpha 1A	Homo sapiens	48-70
33790688-1	2019	Isoprene was efficiently converted to 1,6-dimethyl-1,5-cyclooctadiene (DMCOD) by selective [4+4]-cycloaddition with a catalyst formed by in situ reduction of [(MePI)FeCl(mu-Cl)]2 (MePI = [2-(2,6-(CH3)2-C6H3-N=C(CH3))-C4H5N]).	isoprene	0-8	serpin family I member 2	Homo sapiens	160-164
32958631-4	2020	Indeed, a main fraction of these lipids, including the lipid II peptidoglycan precursor, now display a saturated isoprene unit at the alpha-position, i.e. the unit closest to the colicin M cleavage site.	isoprene	113-121	Colicin-M	Escherichia coli	179-188
32817466-4	2020	Comparison of NgBR/DHDDS with homodimeric cis-PTase structures leads to a model where the elongating isoprene chain extends beyond the enzyme"s active site tunnel, and an insert within the alpha3 helix helps to stabilize this energetically unfavorable state to enable long-chain synthesis to occur.	isoprene	101-109	NUS1 dehydrodolichyl diphosphate synthase subunit	Homo sapiens	14-18
32817466-4	2020	Comparison of NgBR/DHDDS with homodimeric cis-PTase structures leads to a model where the elongating isoprene chain extends beyond the enzyme"s active site tunnel, and an insert within the alpha3 helix helps to stabilize this energetically unfavorable state to enable long-chain synthesis to occur.	isoprene	101-109	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	19-24
32321826-4	2020	Methyl vinyl ketone oxide (MVK-oxide) is a four-carbon, asymmetric, resonance-stabilized CI, produced with 21 to 23% yield from isoprene ozonolysis, yet its reactivity has not been directly studied.	isoprene	128-136	mevalonate kinase	Homo sapiens	27-30
31626530-1	2019	Copolymerization of isoprene (IP) with glycidyl methacrylate (GMA) was performed under RAFT (reversible addition-fragmentation chain-transfer) polymerization conditions in a platform for high-output experimentation.	isoprene	20-28	succinate dehydrogenase complex iron sulfur subunit B	Rattus norvegicus	30-32
33211784-3	2020	This study focuses on characterizing the catalyzed isomerization and adduct formation pathways for the reaction between formic acid and methyl vinyl ketone oxide (MVK-oxide), a four-carbon unsaturated Criegee intermediate generated from isoprene ozonolysis.	isoprene	237-245	mevalonate kinase	Homo sapiens	163-166
32585482-11	2020	RO2 + HO2 pathway derived 2-methyltetrols (2-MTs) predominated the EFs of isoprene-derived products (SOAi) in the fresh samples.	isoprene	74-82	heme oxygenase 2	Homo sapiens	6-9
32560078-5	2020	In particular, we found that isoprene enhanced stomatal sensitivity to ABA through upregulation of RD29B signaling gene.	isoprene	29-37	CAP160 protein	Arabidopsis thaliana	99-104
32560078-7	2020	In leaves, isoprene caused the downregulation of COR15A and P5CS genes, suggesting that the enhanced tolerance to water-deprivation stress observed in isoprene-emitting plants may be mediated chiefly by an enhanced membrane integrity and tolerance to osmotic stress.	isoprene	11-19	cold-regulated 15a	Arabidopsis thaliana	49-55
32560078-7	2020	In leaves, isoprene caused the downregulation of COR15A and P5CS genes, suggesting that the enhanced tolerance to water-deprivation stress observed in isoprene-emitting plants may be mediated chiefly by an enhanced membrane integrity and tolerance to osmotic stress.	isoprene	151-159	cold-regulated 15a	Arabidopsis thaliana	49-55
31891925-5	2020	The effect of surface adsorption of water vapor, oxygen, ammonia and isoprene gas phase molecules on the Ids was measured.	isoprene	69-77	iduronate 2-sulfatase	Homo sapiens	105-108
33790688-1	2019	Isoprene was efficiently converted to 1,6-dimethyl-1,5-cyclooctadiene (DMCOD) by selective [4+4]-cycloaddition with a catalyst formed by in situ reduction of [(MePI)FeCl(mu-Cl)]2 (MePI = [2-(2,6-(CH3)2-C6H3-N=C(CH3))-C4H5N]).	isoprene	0-8	serpin family I member 2	Homo sapiens	180-184
30681102-0	2019	Anilido-oxazoline-ligated rare-earth metal complexes: synthesis, characterization and highly cis-1,4-selective polymerization of isoprene.	isoprene	129-137	cytokine inducible SH2 containing protein	Homo sapiens	93-98
31667449-7	2019	In contrast, the major portion of aqueous aerosol and in-cloud PON, which retains its nitrate moiety, are soluble isoprene nitrates.	isoprene	114-131	paraoxonase 1	Homo sapiens	63-66
30681102-2	2019	The complexes exhibited strong fluorescence emissions and good catalytic performance on isoprene polymerization with high cis-1,4-selectivity.	isoprene	88-96	cytokine inducible SH2 containing protein	Homo sapiens	122-127
30681102-8	2019	Upon activation with organic borates, the reported complexes exhibited high activity and cis-1,4-selectivity for isoprene polymerization.	isoprene	113-121	cytokine inducible SH2 containing protein	Homo sapiens	89-94
30615840-3	2019	Using a high-level multiconformer transition state theory (MC-TST) approach, we determine recommended temperature dependent reaction rate coefficients for a number of the H-shift reactions in the isoprene oxidation mechanism.	isoprene	196-204	thiosulfate sulfurtransferase	Homo sapiens	62-65
30577128-6	2019	DEGs involved in isoprene biosynthesis and phytohormones signal pathways indicate the molecular response and stomatal closure of poplar under O3 and/or drought might be through MEP/DOXP and ABA-dependent pathways.	isoprene	17-25	cathepsin L	Homo sapiens	177-180
31872748-43	2019	We have demonstrated that the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the redox-sensitive activation protein-1 (AP-1) transcription factor networks have been significantly altered upon exposure to isoprene-derived SOA.	isoprene	212-220	NFE2 like bZIP transcription factor 2	Homo sapiens	30-73
31872748-43	2019	We have demonstrated that the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the redox-sensitive activation protein-1 (AP-1) transcription factor networks have been significantly altered upon exposure to isoprene-derived SOA.	isoprene	212-220	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
31872748-44	2019	The identification of Nrf2 pathway in cells exposed to isoprene-derived SOA is in accordance with our findings using the DTT assay, which measures the thiol reactivity of PM samples as a surrogate for their ROS-generation potential.	isoprene	55-63	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
30485103-1	2018	Atmospheric concentrations of isoprene (2-methylbutadiene) in environmental research and in exhaled breath for medical research are usually measured by soft chemical ionization mass spectrometry that relies on a knowledge of the kinetics of the gas phase reactions of H3O+, NO+ or O2+  ions with isoprene molecules.	isoprene	30-38	H3 clustered histone 15	Homo sapiens	268-271
30485103-1	2018	Atmospheric concentrations of isoprene (2-methylbutadiene) in environmental research and in exhaled breath for medical research are usually measured by soft chemical ionization mass spectrometry that relies on a knowledge of the kinetics of the gas phase reactions of H3O+, NO+ or O2+  ions with isoprene molecules.	isoprene	40-57	H3 clustered histone 15	Homo sapiens	268-271
30485103-1	2018	Atmospheric concentrations of isoprene (2-methylbutadiene) in environmental research and in exhaled breath for medical research are usually measured by soft chemical ionization mass spectrometry that relies on a knowledge of the kinetics of the gas phase reactions of H3O+, NO+ or O2+  ions with isoprene molecules.	isoprene	296-304	H3 clustered histone 15	Homo sapiens	268-271
30137992-1	2018	The reaction of the OH radical with isoprene, C5H8 (R1), has been studied over the temperature range 298-794 K and bath gas pressures of nitrogen from 50 to 1670 Torr using laser flash photolysis (LFP) to generate OH and laser-induced fluorescence (LIF) to observe OH removal.	isoprene	36-44	CD1b molecule	Homo sapiens	46-54
30192520-9	2018	Addition of isoprene (C5H8), producing C5-RO2 radicals, leads to C15 accretion products formed via cross-reactions with C10-RO2 radicals.	isoprene	12-20	placenta associated 8	Homo sapiens	65-68
30192520-9	2018	Addition of isoprene (C5H8), producing C5-RO2 radicals, leads to C15 accretion products formed via cross-reactions with C10-RO2 radicals.	isoprene	12-20	chromosome 12 open reading frame 57	Homo sapiens	120-123
30599734-1	2018	Ozonolysis of isoprene, one of the most abundant volatile organic compounds in the atmosphere, proceeds through methyl vinyl ketone oxide (MVK-oxide), methacrolein oxide, and formaldehyde oxide (CH2OO) Criegee intermediates.	isoprene	14-22	mevalonate kinase	Homo sapiens	139-142
29943085-3	2018	The present study was designed to evaluate the cardiac effects of inhaled simulated smog atmospheres (SA) generated from the photochemistry of either gasoline and isoprene (SA-G) or isoprene (SA-Is) in mice.	isoprene	163-171	S-antigen, retina and pineal gland (arrestin)	Mus musculus	173-177
30195860-6	2018	With the MPG, up to 352 of concentration factor can be achieved for 10 ppb isoprene.	isoprene	75-83	N-methylpurine DNA glycosylase	Homo sapiens	9-12
30074392-3	2018	In particular, unimolecular decay of MVK-OO is predicted to be the major source of hydroxyl radicals (OH) in isoprene ozonolysis.	isoprene	109-117	mevalonate kinase	Homo sapiens	37-40
29504174-0	2018	Controlled Polymerization of Isoprene with Chromium-Based Metal-Organic Framework Catalysts: Switching from Cyclic to cis-1,4-Selectivity Depending on Activator.	isoprene	29-37	cytokine inducible SH2 containing protein	Homo sapiens	118-123
30960859-0	2018	Influences of Fluorine Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization.	isoprene	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
30960859-1	2018	A series of iminopyridine complexes of Fe(II) and Co(II) complexes bearing fluorinated aryl substituents were synthesized for the polymerization of isoprene.	isoprene	148-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29504174-1	2018	Chromium-based metal-organic framework (MOF) Cr-MIL-100/101 activated by activator and aluminum trialkyl compound serve as unique, highly efficient heterogeneous single-site catalysts for the controlled polymerization of isoprene, which not only exhibit quasi-living nature in isoprene polymerization but also unprecedentedly switch from cyclic to cis-1,4-selectivity depending on the activator used to yield low molecular weight cyclic PIPs or extremely high molecular weight cis-1,4-PIPs.	isoprene	221-229	cytokine inducible SH2 containing protein	Homo sapiens	348-353
29504174-1	2018	Chromium-based metal-organic framework (MOF) Cr-MIL-100/101 activated by activator and aluminum trialkyl compound serve as unique, highly efficient heterogeneous single-site catalysts for the controlled polymerization of isoprene, which not only exhibit quasi-living nature in isoprene polymerization but also unprecedentedly switch from cyclic to cis-1,4-selectivity depending on the activator used to yield low molecular weight cyclic PIPs or extremely high molecular weight cis-1,4-PIPs.	isoprene	221-229	cytokine inducible SH2 containing protein	Homo sapiens	477-482
28581006-0	2017	Investigation of the reaction of ozone with isoprene, methacrolein and methyl vinyl ketone using the HELIOS chamber.	isoprene	44-52	IKAROS family zinc finger 2	Homo sapiens	101-107
29385329-1	2018	Oxidation of isoprene by hydroxyl radical (OH), ozone (O3), or nitrate radical (NO3) leads to the formation of secondary organic aerosol (SOA) in the atmosphere.	isoprene	13-21	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
29135079-10	2018	Taken together, these results indicate that CS and IP may inhibit the development of placenta via activation of ROS by inducing apoptosis and autophagy by affecting the expression of KEAP1, which regulates Nrf2 expression.	isoprene	51-53	kelch like ECH associated protein 1	Homo sapiens	183-188
29135079-10	2018	Taken together, these results indicate that CS and IP may inhibit the development of placenta via activation of ROS by inducing apoptosis and autophagy by affecting the expression of KEAP1, which regulates Nrf2 expression.	isoprene	51-53	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
30965837-0	2017	Cis-1,4-Polymerization of Isoprene by 1,3-Bis(oxazolinymethylidene)isoindoline-Ligated Rare-Earth Metal Dialkyl Complexes.	isoprene	26-34	suppressor of cytokine signaling 1	Homo sapiens	0-5
30965837-3	2017	In the presence of a cocatalyst such as borate and AlR3, these complexes 1-3 exhibit high activities of up to 6.8 x 104 (g of polymer)/(molLn h) and high cis-1,4 selectivities of up to 97% in the polymerization of isoprene in toluene, yielding the cis-1,4-polyisoprenes with heavy molecular weights (Mn of up to 710,000 g/mol) and bimodal molecular weight distributions (Mw/Mn = 2.0-4.5).	isoprene	214-222	suppressor of cytokine signaling 1	Homo sapiens	154-159
30965837-3	2017	In the presence of a cocatalyst such as borate and AlR3, these complexes 1-3 exhibit high activities of up to 6.8 x 104 (g of polymer)/(molLn h) and high cis-1,4 selectivities of up to 97% in the polymerization of isoprene in toluene, yielding the cis-1,4-polyisoprenes with heavy molecular weights (Mn of up to 710,000 g/mol) and bimodal molecular weight distributions (Mw/Mn = 2.0-4.5).	isoprene	214-222	suppressor of cytokine signaling 1	Homo sapiens	248-253
28749006-6	2017	Furthermore, the copolymerization of polar MBEF and nonpolar isoprene is also successfully realized by the bis(phosphino) carbazoleide-ligated scandium analog to access furan-modified cis-1,4 (&gt;97%) polyisoprene with different MBEF contents (5.3%, 8.7%).	isoprene	61-69	cytokine inducible SH2 containing protein	Homo sapiens	184-189
28577910-2	2017	An interesting illustration of this versatility can be found in the reaction catalyzed by the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2) - an enzyme that interconverts the two essential isoprene units (isopentenyl pyrophosphate and dimethylallyl pyrophosphate) that are needed to initiate the biosynthesis of all isoprenoids.	isoprene	219-227	isopentenyl-diphosphate delta isomerase 2	Homo sapiens	163-168
28660461-1	2017	Rubber is a polymer of isoprene, consisting mainly of cis-1,4-polyisoprene units.	isoprene	23-31	suppressor of cytokine signaling 1	Homo sapiens	54-59
28068985-6	2017	The optimized process using 10 balanced enzyme unites (5.0 microM of MVK, PMK, MVD; 10.0 microM of IDI, 80.0 microM of ISPS) could produce 6323.5 micromol/L/h (430 mg/L/h) isoprene in a 2 ml in vitro system.	isoprene	172-180	mevalonate kinase	Homo sapiens	69-72
28334669-0	2017	Distribution and sea-to-air flux of isoprene in the East China Sea and the South Yellow Sea during summer.	isoprene	36-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	17-20
28334669-0	2017	Distribution and sea-to-air flux of isoprene in the East China Sea and the South Yellow Sea during summer.	isoprene	36-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
28334669-0	2017	Distribution and sea-to-air flux of isoprene in the East China Sea and the South Yellow Sea during summer.	isoprene	36-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	88-91
28334669-1	2017	Spatial distribution and sea-to-air flux of isoprene in the East China Sea and the South Yellow Sea in July 2013 were investigated.	isoprene	44-52	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
28334669-9	2017	In addition, sea-to-air fluxes of isoprene approximately ranged from 22.17 nmol m-2 d-1-537.2 nmol m-2 d-1, with an average of 161.5 +- 133.3 nmol m-2 d-1.	isoprene	34-42	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	13-16
28068985-6	2017	The optimized process using 10 balanced enzyme unites (5.0 microM of MVK, PMK, MVD; 10.0 microM of IDI, 80.0 microM of ISPS) could produce 6323.5 micromol/L/h (430 mg/L/h) isoprene in a 2 ml in vitro system.	isoprene	172-180	phosphomevalonate kinase	Homo sapiens	74-77
28068985-6	2017	The optimized process using 10 balanced enzyme unites (5.0 microM of MVK, PMK, MVD; 10.0 microM of IDI, 80.0 microM of ISPS) could produce 6323.5 micromol/L/h (430 mg/L/h) isoprene in a 2 ml in vitro system.	isoprene	172-180	mevalonate diphosphate decarboxylase	Homo sapiens	79-82
28034770-8	2017	Combinatorial mutagenesis of the resulting ISPS mutants generated the best mutant ISPSM4, introduction of which into the GAL4-overexpressing strain YXM29 achieved 50.2mg/L of isoprene in sealed vials, and the isoprene production reached 640mg/L and 3.7g/L in aerobic batch and fed-batch fermentations, respectively.	isoprene	175-183	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	121-125
28034770-8	2017	Combinatorial mutagenesis of the resulting ISPS mutants generated the best mutant ISPSM4, introduction of which into the GAL4-overexpressing strain YXM29 achieved 50.2mg/L of isoprene in sealed vials, and the isoprene production reached 640mg/L and 3.7g/L in aerobic batch and fed-batch fermentations, respectively.	isoprene	209-217	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	121-125
27262990-5	2016	In addition, FA, Bz, and IP increased the protein expression of pro-apoptotic genes, C/EBP homologous protein (CHOP) and Bax, and reduced the protein expression of anti-apoptotic gene, Bcl-2.	isoprene	25-27	DNA damage inducible transcript 3	Homo sapiens	85-109
30974663-0	2016	Influences of Alkyl and Aryl Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization.	isoprene	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
27436785-0	2016	Catalytic Enantioselective Conjugate Additions of (pin)B-Substituted Allylcopper Compounds Generated in situ from Butadiene or Isoprene.	isoprene	127-135	dynein light chain LC8-type 1	Homo sapiens	51-54
27262990-5	2016	In addition, FA, Bz, and IP increased the protein expression of pro-apoptotic genes, C/EBP homologous protein (CHOP) and Bax, and reduced the protein expression of anti-apoptotic gene, Bcl-2.	isoprene	25-27	DNA damage inducible transcript 3	Homo sapiens	111-115
27262990-5	2016	In addition, FA, Bz, and IP increased the protein expression of pro-apoptotic genes, C/EBP homologous protein (CHOP) and Bax, and reduced the protein expression of anti-apoptotic gene, Bcl-2.	isoprene	25-27	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124
27262990-5	2016	In addition, FA, Bz, and IP increased the protein expression of pro-apoptotic genes, C/EBP homologous protein (CHOP) and Bax, and reduced the protein expression of anti-apoptotic gene, Bcl-2.	isoprene	25-27	BCL2 apoptosis regulator	Homo sapiens	185-190
27264840-8	2016	The resulting activities of up to 6 x 10(5) mol isoprene per mol Co per h are the highest yet recorded for catalysts selective for cis-1,4 enchained polyisoprene.	isoprene	48-56	suppressor of cytokine signaling 1	Homo sapiens	131-136
27010702-5	2016	When nitrate (NO3) radicals are suppressed, high isoprene persists through the night, providing photochemical fuel upon daybreak and leading to a dramatic late-morning ozone peak.	isoprene	49-57	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
27010702-6	2016	On nights with significant NO3, isoprene is removed before dawn; days with low morning isoprene then have lower ozone with a more typical afternoon peak.	isoprene	32-40	NBL1, DAN family BMP antagonist	Homo sapiens	27-30