PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26876283-5	2016	HIV-1 replication was impaired when TopoIIbeta was down regulated by siRNA and inhibited by ICRF-193 and merbarone.	merbarone	105-114	DNA topoisomerase II beta	Homo sapiens	36-46
26876283-9	2016	In addition, a decreased viral gene expression on treatment with merbarone exemplifies the importance of catalytic activity of TopoIIbeta in viral replication.	merbarone	65-74	DNA topoisomerase II beta	Homo sapiens	127-137
16434617-0	2006	Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix.	merbarone	0-9	DNA fragmentation factor subunit beta	Homo sapiens	32-55
17983804-7	2007	The Topo II inhibitors, merbarone and etoposide, suppressed the beta-catenin-mediated TCF/lymphoid enhancer factor transcriptional activity.	merbarone	24-33	catenin beta 1	Homo sapiens	64-76
17983804-7	2007	The Topo II inhibitors, merbarone and etoposide, suppressed the beta-catenin-mediated TCF/lymphoid enhancer factor transcriptional activity.	merbarone	24-33	hepatocyte nuclear factor 4 alpha	Homo sapiens	86-89
24040417-6	2013	Co-treatment of thyroid cells with APH and the topoisomerase catalytic inhibitors, betulinic acid and merbarone, significantly decreased APH-induced fragile site breakage within RET intron 11 and within the common fragile site FRA3B.	merbarone	102-111	ret proto-oncogene	Homo sapiens	178-181
24040417-6	2013	Co-treatment of thyroid cells with APH and the topoisomerase catalytic inhibitors, betulinic acid and merbarone, significantly decreased APH-induced fragile site breakage within RET intron 11 and within the common fragile site FRA3B.	merbarone	102-111	fragile histidine triad diadenosine triphosphatase	Homo sapiens	227-232
16434617-5	2006	Instead, merbarone induced rapid activation of the mitochondrial apoptosis pathway, which included the following temporal sequence of events: dissipation of the mitochondrial transmembrane potential within 30 min, release of mitochondrial cytochrome c, and activation of caspase-activated DNase (CAD) by its inhibitor ICAD.	merbarone	9-18	cytochrome c, somatic	Homo sapiens	239-251
16434617-5	2006	Instead, merbarone induced rapid activation of the mitochondrial apoptosis pathway, which included the following temporal sequence of events: dissipation of the mitochondrial transmembrane potential within 30 min, release of mitochondrial cytochrome c, and activation of caspase-activated DNase (CAD) by its inhibitor ICAD.	merbarone	9-18	DNA fragmentation factor subunit beta	Homo sapiens	271-294
16434617-5	2006	Instead, merbarone induced rapid activation of the mitochondrial apoptosis pathway, which included the following temporal sequence of events: dissipation of the mitochondrial transmembrane potential within 30 min, release of mitochondrial cytochrome c, and activation of caspase-activated DNase (CAD) by its inhibitor ICAD.	merbarone	9-18	DNA fragmentation factor subunit beta	Homo sapiens	296-299
16434617-5	2006	Instead, merbarone induced rapid activation of the mitochondrial apoptosis pathway, which included the following temporal sequence of events: dissipation of the mitochondrial transmembrane potential within 30 min, release of mitochondrial cytochrome c, and activation of caspase-activated DNase (CAD) by its inhibitor ICAD.	merbarone	9-18	DNA fragmentation factor subunit alpha	Homo sapiens	318-322
16434617-6	2006	The excision of high molecular weight DNA was inhibited at least 80% in merbarone-treated cells preincubated with the pan-caspase inhibitor z-VAD-fmk [Z-Val-Ala-Asp(OMe)-fluoromethyl ketone] and in caspase-resistant Jurkat cells (ICAD/double-mutated) that express a mutant form of ICAD.	merbarone	72-81	DNA fragmentation factor subunit alpha	Homo sapiens	230-234
16434617-6	2006	The excision of high molecular weight DNA was inhibited at least 80% in merbarone-treated cells preincubated with the pan-caspase inhibitor z-VAD-fmk [Z-Val-Ala-Asp(OMe)-fluoromethyl ketone] and in caspase-resistant Jurkat cells (ICAD/double-mutated) that express a mutant form of ICAD.	merbarone	72-81	DNA fragmentation factor subunit alpha	Homo sapiens	281-285
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-101
12874009-2	2003	Here, we investigate the role of p53 in the G(2) arrest that occurs in response to the topoisomerase inhibitors etoposide and merbarone.	merbarone	126-135	tumor protein p53	Homo sapiens	33-36
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-160
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	caspase 3	Homo sapiens	191-200
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	caspase 3	Homo sapiens	201-206
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	caspase 1	Homo sapiens	229-238
10051540-4	1999	Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase.	merbarone	65-74	poly(ADP-ribose) polymerase 1	Homo sapiens	272-299
10051540-6	1999	6-dichlorobenzoyloxymethyl-ketone, inhibited merbarone-induced caspase-3/CPP32-like activity and apoptosis in a dose-dependent manner.	merbarone	45-54	caspase 3	Homo sapiens	63-72
10051540-6	1999	6-dichlorobenzoyloxymethyl-ketone, inhibited merbarone-induced caspase-3/CPP32-like activity and apoptosis in a dose-dependent manner.	merbarone	45-54	caspase 3	Homo sapiens	73-78
10051540-7	1999	These results indicate that the catalytic inhibition of topo II by merbarone leads to apoptotic cell death through a caspase-3-like protease-dependent mechanism.	merbarone	67-76	caspase 3	Homo sapiens	117-126
10051540-8	1999	These results further suggest that c-Jun and c-Jun NH2-terminal kinase/stress-activated protein kinase signaling may be involved in the cytotoxicity of merbarone.	merbarone	152-161	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40
10051540-8	1999	These results further suggest that c-Jun and c-Jun NH2-terminal kinase/stress-activated protein kinase signaling may be involved in the cytotoxicity of merbarone.	merbarone	152-161	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
9927611-6	1999	For instance, complex-stabilizing Topo II inhibitors such as etoposide, teniposide, and doxorubicin, which cause DNA damage, strongly induce FasL expression; by contrast, non-DNA-damaging catalytic Topo II inhibitors such as ICRF-187 and merbarone do not do this.	merbarone	238-247	Fas ligand	Homo sapiens	141-145
9371492-0	1997	Down-regulation of topoisomerase IIalpha in CEM cells selected for merbarone resistance is associated with reduced expression of Sp3.	merbarone	67-76	Sp3 transcription factor	Homo sapiens	129-132
34961037-6	2021	Somatic and meiotic anaphase bridges appeared in the topbp1 mutant at similar frequencies to those when TOPII was inhibited with merbarone, etoposide, or ICFR-187.	merbarone	129-138	topoisomerase II	Arabidopsis thaliana	104-109
8759037-5	1996	Conversely, preincubation with merbarone resulted in less inhibition of VP-16-induced topoisomerase II-DNA covalent complexes in K/VP.5 cells than in parental K562 cells.	merbarone	31-40	host cell factor C1	Homo sapiens	72-77
2557897-7	1989	Teniposide and merbarone selectively inhibited catalytic activity of p170, requiring concentrations 3-fold and 8-fold lower, respectively, than those required for equivalent inhibition of p180.	merbarone	15-24	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	188-192
2598397-10	1989	Merbarone produced small elevations in serum transaminase activities [i.e., glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT)] at doses that produced marked alterations in renal function in female rats, suggesting only mild hepatotoxicity.	merbarone	0-9	glutamic--pyruvic transaminase	Rattus norvegicus	116-145
2478139-11	1989	Merbarone, a novel, third type of topoisomerase II inhibitor, blocked MT-II transcription at 50-100 microM.	merbarone	0-9	metallothionein-2	Cricetulus griseus	70-75
2598397-10	1989	Merbarone produced small elevations in serum transaminase activities [i.e., glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT)] at doses that produced marked alterations in renal function in female rats, suggesting only mild hepatotoxicity.	merbarone	0-9	glutamic--pyruvic transaminase	Rattus norvegicus	147-150
31271486-6	2019	Furthermore, we show that HMGA2 significantly reduced genotoxic DNA damage in each tested cancer cell model during treatment with the TOP2A poison etoposide or the catalytic TOP2A inhibitor merbarone.	merbarone	190-199	high mobility group AT-hook 2	Homo sapiens	26-31
31271486-6	2019	Furthermore, we show that HMGA2 significantly reduced genotoxic DNA damage in each tested cancer cell model during treatment with the TOP2A poison etoposide or the catalytic TOP2A inhibitor merbarone.	merbarone	190-199	DNA topoisomerase II alpha	Homo sapiens	174-179