PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34871443-9	2021	We thus propose that Vid22 is directly involved in genome integrity maintenance as a novel regulator of G4 metabolism.	Dichlorophen	104-106	Vid22p	Saccharomyces cerevisiae S288C	21-26
34855372-3	2021	Herein, we report the first example of an endogenous protein, Cockayne Syndrome B (CSB), that can bind selectively with picomolar affinity toward intermolecular G4s formed within rDNA while displaying negligible binding toward intramolecular structures.	Dichlorophen	161-164	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	62-81
34855372-3	2021	Herein, we report the first example of an endogenous protein, Cockayne Syndrome B (CSB), that can bind selectively with picomolar affinity toward intermolecular G4s formed within rDNA while displaying negligible binding toward intramolecular structures.	Dichlorophen	161-164	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	83-86
34232992-3	2021	We show herein that the SARS-CoV-2 Nsp3 protein also contains a SUD domain that interacts with G4s.	Dichlorophen	95-98	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	35-39
34215036-7	2021	Our results showed that both K+ and NH4+ can induce the random-coiled c-KIT DNA to unfold and form a more unstretched intermediate state and then fold into tightly structured G4s with smaller size.	Dichlorophen	175-178	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
34926957-4	2021	We found that both G4s bind to hnRNPA1 and its proteolytic fragment UP1, promoting several contacts with the RRM protein domains.	Dichlorophen	19-22	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	31-38
34926957-4	2021	We found that both G4s bind to hnRNPA1 and its proteolytic fragment UP1, promoting several contacts with the RRM protein domains.	Dichlorophen	19-22	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	68-71
34743173-9	2021	p53 inactivation abrogated cell cycle arrest and reduced G4 accumulation in NGP clones.	Dichlorophen	57-59	tumor protein p53	Homo sapiens	0-3
34289065-5	2021	Unlike many G4 binders, the compound was found to bind to a pocket at the base of the hairpin region of the MYCN G4.	Dichlorophen	12-14	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	108-112
34113828-5	2021	RPA also differentially interacts with the folded G4s.	Dichlorophen	50-53	replication protein A1	Homo sapiens	0-3
34209337-2	2021	We aimed to clarify the role of G4s in CTCF positioning.	Dichlorophen	32-35	CCCTC-binding factor	Homo sapiens	39-43
34209337-4	2021	G4s bound CTCF with Kd values similar to that of the control duplex, while respective i-motifs exhibited no affinity for CTCF.	Dichlorophen	0-3	CCCTC-binding factor	Homo sapiens	10-14
34209337-10	2021	One of such proteins, HMGN3, contributes to the association between G4s and CTCF according to our bioinformatics analysis.	Dichlorophen	68-71	high mobility group nucleosomal binding domain 3	Homo sapiens	22-27
34209337-10	2021	One of such proteins, HMGN3, contributes to the association between G4s and CTCF according to our bioinformatics analysis.	Dichlorophen	68-71	CCCTC-binding factor	Homo sapiens	76-80
34209337-11	2021	These findings support both direct and indirect roles of G4s in CTCF recruitment.	Dichlorophen	57-60	CCCTC-binding factor	Homo sapiens	64-68
34139671-3	2021	We previously showed that, in cultured primary neurons, small-molecule G4 stabilizers promote formation of DNA double-strand breaks (DSBs) and downregulate the Brca1 gene.	Dichlorophen	71-73	BRCA1 DNA repair associated	Homo sapiens	160-165
34107835-0	2021	Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat.	Dichlorophen	0-13	aryl hydrocarbon receptor	Rattus norvegicus	24-49
34107835-0	2021	Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat.	Dichlorophen	0-13	aryl hydrocarbon receptor	Rattus norvegicus	51-54
34107835-0	2021	Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat.	Dichlorophen	0-13	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	60-90
34107835-0	2021	Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat.	Dichlorophen	0-13	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	92-96
34107835-6	2021	Two important proinflammatory cytokines, IL-6 and TNF-alpha were found to be elevated upon DCP treatment.	Dichlorophen	91-94	interleukin 6	Rattus norvegicus	41-45
34107835-6	2021	Two important proinflammatory cytokines, IL-6 and TNF-alpha were found to be elevated upon DCP treatment.	Dichlorophen	91-94	tumor necrosis factor	Rattus norvegicus	50-59
34107835-7	2021	Moreover, DCP also caused activation of AhR and IDO1 with simultaneous down regulation of Nrf2.	Dichlorophen	10-13	aryl hydrocarbon receptor	Rattus norvegicus	40-43
34107835-7	2021	Moreover, DCP also caused activation of AhR and IDO1 with simultaneous down regulation of Nrf2.	Dichlorophen	10-13	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	48-52
34107835-7	2021	Moreover, DCP also caused activation of AhR and IDO1 with simultaneous down regulation of Nrf2.	Dichlorophen	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
34113828-9	2021	We finally proposed the mechanisms underlying above functions of RPA in preventing, resolving, and assisting helicases to eliminate G4s.	Dichlorophen	132-135	replication protein A1	Homo sapiens	65-68
35037383-6	2022	The aerobic oxidation of glucose by GOx yields H2 O2 that fuels the hemin/G4-catalyzed oxidation of NOHA into citrulline.	Dichlorophen	74-76	hydroxyacid oxidase 1	Homo sapiens	36-39
35608081-3	2022	Aiming at speeding up the identification of G4-targeting synthetic or natural compounds, we developed an affinity chromatography-based assay, named G-quadruplex on Oligo Affinity Support (G4-OAS), by synthesizing G4-forming sequences on commercially available polystyrene OAS.	Dichlorophen	44-46	SPARC related modular calcium binding 1	Homo sapiens	191-194
35608081-3	2022	Aiming at speeding up the identification of G4-targeting synthetic or natural compounds, we developed an affinity chromatography-based assay, named G-quadruplex on Oligo Affinity Support (G4-OAS), by synthesizing G4-forming sequences on commercially available polystyrene OAS.	Dichlorophen	44-46	SPARC related modular calcium binding 1	Homo sapiens	272-275
35100428-4	2022	The selectivity of Vimentin for G4 repeats versus individual G4s provides an unprecedented result.	Dichlorophen	61-64	vimentin	Homo sapiens	19-27
34040612-4	2021	In vitro studies have shown G4s to form and bind AID in Ig switch (S) regions.	Dichlorophen	28-31	activation induced cytidine deaminase	Homo sapiens	49-52
35133472-8	2022	In vitro cytotoxicity assay showed that the SAC-TRAIL fusion protein, which contained a flexible linker (G4S)3, optimally inhibited the proliferation of cancer cells.	Dichlorophen	105-108	TNF superfamily member 10	Homo sapiens	48-53
35049665-10	2022	Therefore, for the first time, we have assessed its binding with G4 at nano-molar concentrations with SPR which seems to be crucial for its binding analyses.	Dichlorophen	65-67	sepiapterin reductase	Mus musculus	102-105
34040612-5	2021	Alterations in the gene encoding AID can further disrupt AID-G4 binding and reduce CSR in vivo.	Dichlorophen	61-63	activation induced cytidine deaminase	Homo sapiens	33-36
34040612-5	2021	Alterations in the gene encoding AID can further disrupt AID-G4 binding and reduce CSR in vivo.	Dichlorophen	61-63	activation induced cytidine deaminase	Homo sapiens	57-60
33953191-6	2021	We find that the resolution of RF-coupled G4s is mediated by an interplay between RPA and the FANCJ helicase.	Dichlorophen	42-45	replication protein A1	Homo sapiens	82-85
33290632-4	2021	In this study, we found that G4 binding to splicing factor 3B subunit 2 (SF3B2) downregulated STAT1 phosphorylation and ISG expression in 3D-cultured cancer cells.	Dichlorophen	29-31	splicing factor 3b subunit 2	Homo sapiens	43-71
33953191-5	2021	These G4s locally perturb replisome dynamics and organization by reducing DNA synthesis and limiting the binding of the single-strand DNA-binding protein RPA.	Dichlorophen	6-9	replication protein A1	Homo sapiens	154-157
33851760-0	2021	G4 Sensing Pyridyl-thiazole Polyamide Represses c-KIT Expression in Leukemia Cells.	Dichlorophen	0-2	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	48-53
34025941-3	2021	Here, we studied the molecular basis for the high affinity and specificity of DHX36 for parallel-type G4s using all-atom molecular dynamics simulations.	Dichlorophen	102-105	DEAH-box helicase 36	Homo sapiens	78-83
33549587-6	2021	At low concentrations, POT1-TPP1 passively captures transiently unfolded G4s.	Dichlorophen	73-76	protection of telomeres 1	Homo sapiens	23-27
33549587-6	2021	At low concentrations, POT1-TPP1 passively captures transiently unfolded G4s.	Dichlorophen	73-76	tripeptidyl peptidase 1	Homo sapiens	28-32
33290632-4	2021	In this study, we found that G4 binding to splicing factor 3B subunit 2 (SF3B2) downregulated STAT1 phosphorylation and ISG expression in 3D-cultured cancer cells.	Dichlorophen	29-31	splicing factor 3b subunit 2	Homo sapiens	73-78
33290632-4	2021	In this study, we found that G4 binding to splicing factor 3B subunit 2 (SF3B2) downregulated STAT1 phosphorylation and ISG expression in 3D-cultured cancer cells.	Dichlorophen	29-31	signal transducer and activator of transcription 1	Homo sapiens	94-99
33290632-9	2021	These observations suggest that G4 disrupts the ability of SF3B2 to induce ISGs in cancer.	Dichlorophen	32-34	splicing factor 3b subunit 2	Homo sapiens	59-64
33617136-4	2021	Our results suggest that RHAU binds not only preferentially to parallel G4s, but also to free external G-quartets.	Dichlorophen	72-75	DEAH-box helicase 36	Homo sapiens	25-29
33347280-15	2021	Later, a close look at NM23-H2-G4 interaction in regulation of the human reverse transcriptase gene (hTERT) revealed the role of G4s in local epigenetic modifications.	Dichlorophen	31-33	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	23-30
33347280-15	2021	Later, a close look at NM23-H2-G4 interaction in regulation of the human reverse transcriptase gene (hTERT) revealed the role of G4s in local epigenetic modifications.	Dichlorophen	31-33	telomerase reverse transcriptase	Homo sapiens	101-106
33347280-15	2021	Later, a close look at NM23-H2-G4 interaction in regulation of the human reverse transcriptase gene (hTERT) revealed the role of G4s in local epigenetic modifications.	Dichlorophen	129-132	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	23-30
33347280-15	2021	Later, a close look at NM23-H2-G4 interaction in regulation of the human reverse transcriptase gene (hTERT) revealed the role of G4s in local epigenetic modifications.	Dichlorophen	129-132	telomerase reverse transcriptase	Homo sapiens	101-106
33347280-19	2021	Moreover, a large fraction of the non-telomeric TRF2 sites comprise G4s.	Dichlorophen	68-71	telomeric repeat binding factor 2	Homo sapiens	48-52
33857359-1	2021	DHX36 is a eukaryotic DEAH/RHA family helicase that disrupts G-quadruplex structures (G4s) with high specificity, contributing to regulatory roles of G4s.	Dichlorophen	86-89	DEAH-box helicase 36	Homo sapiens	0-5
33857359-7	2021	Together, our results animate recent DHX36 crystal structures, suggesting a model in which the DSM recruits G4s in a modular and flexible manner by contacting the 5" face early in binding, prior to rate-limiting capture and disruption of the G4 by the helicase core.	Dichlorophen	108-111	DEAH-box helicase 36	Homo sapiens	37-42
31892093-2	2020	Interestingly, the peptide not only served as recognition probe to detect PSA, but also acted as the enhancer to improve the enzyme activity of hemin/G4, which promoted the detection sensitivity.	Dichlorophen	150-152	kallikrein related peptidase 3	Homo sapiens	74-77
33098766-5	2020	Our findings indicate a crucial role for G4 binding in AID targeting and suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to the physiology and pathology of activated B cells.	Dichlorophen	41-43	activation induced cytidine deaminase	Homo sapiens	55-58
33098766-5	2020	Our findings indicate a crucial role for G4 binding in AID targeting and suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to the physiology and pathology of activated B cells.	Dichlorophen	41-43	activation induced cytidine deaminase	Homo sapiens	86-89
32454109-4	2020	First, we questioned whether exogenous G4s that recognize cell-surface NCL and could trap other HCs in the nucleus are usable as anticancer agents.	Dichlorophen	39-42	nucleolin	Homo sapiens	71-74
32454109-7	2020	The presumed NCL-regulated intracellular transport of G4s was inefficient or insufficient for tumor-specific G4 delivery.	Dichlorophen	54-57	nucleolin	Homo sapiens	13-16
32454109-7	2020	The presumed NCL-regulated intracellular transport of G4s was inefficient or insufficient for tumor-specific G4 delivery.	Dichlorophen	54-56	nucleolin	Homo sapiens	13-16
32596589-4	2020	While several studies revealed the mechanism of G4 binding and unfolding by the conserved RecQ C-terminal (RQC) domain of BLM, how RQC recognizes different G4 topologies is still unclear.	Dichlorophen	48-50	BLM RecQ like helicase	Homo sapiens	122-125
32596589-12	2020	By this information, our research provides new insights into the influence of G4 structure on DNA metabolic processes involving BLM.	Dichlorophen	78-80	BLM RecQ like helicase	Homo sapiens	128-131
29543290-5	2018	The photocatalytic reaction rate constants of phenol and dichlorophen on HPT550 porous TiO2 hollow spheres were about ~4 and ~2 times higher than those on P25, respectively.	Dichlorophen	57-69	tubulin polymerization promoting protein	Homo sapiens	155-158
30188709-2	2018	A library of differently functionalized naphthalene diimides (NDIs) was screened for their ability to stabilize AR G4s: the core-extended NDI (7) stood out as the most promising ligand.	Dichlorophen	115-118	androgen receptor	Homo sapiens	112-114
31670046-5	2020	The s-inG4-G4 dimer cause significant red shifts in the excitation and emission bands of OH2PP in contrast to the us-inG4-G4 dimer and G4 monomers.	Dichlorophen	8-10	inhibitor of growth family member 4	Homo sapiens	117-121
31340040-2	2019	Pif1 is a 5" to 3" helicase, localized to both the mitochondria and nucleus that can unwind G4s in vitro and prevent fork stalling at G4 forming sequences in vivo.	Dichlorophen	92-95	PIF1 5'-to-3' DNA helicase	Homo sapiens	0-4