PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12207635-0	2002	The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.	z-4-hydroxy-tamoxifen	98-119	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	17-23
14678248-0	2003	Oxidative metabolism of tamoxifen to Z-4-hydroxy-tamoxifen by cytochrome P450 isoforms: an appraisal of in vitro studies.	z-4-hydroxy-tamoxifen	37-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-77
12207635-5	2002	RESULTS: Z-4-hydroxy-tamoxifen was formed by supersomes expressing CYP2B6, CYP2C9, CYP2C19 and CYP2D6, but not CYP3A4.	z-4-hydroxy-tamoxifen	9-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	67-73
12207635-0	2002	The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.	z-4-hydroxy-tamoxifen	98-119	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	25-31
12207635-5	2002	RESULTS: Z-4-hydroxy-tamoxifen was formed by supersomes expressing CYP2B6, CYP2C9, CYP2C19 and CYP2D6, but not CYP3A4.	z-4-hydroxy-tamoxifen	9-30	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	75-81
12207635-5	2002	RESULTS: Z-4-hydroxy-tamoxifen was formed by supersomes expressing CYP2B6, CYP2C9, CYP2C19 and CYP2D6, but not CYP3A4.	z-4-hydroxy-tamoxifen	9-30	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	83-90
12207635-0	2002	The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.	z-4-hydroxy-tamoxifen	98-119	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	36-42
12207635-5	2002	RESULTS: Z-4-hydroxy-tamoxifen was formed by supersomes expressing CYP2B6, CYP2C9, CYP2C19 and CYP2D6, but not CYP3A4.	z-4-hydroxy-tamoxifen	9-30	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	95-101
12207635-1	2002	AIMS: To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen.	z-4-hydroxy-tamoxifen	164-185	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	84-90
12207635-6	2002	In agreement with these data, the mean formation of Z-4-hydroxy-tamoxifen was inhibited 49% by sulphaphenazole (P=0.001), 38% by quinidine (P<0.05) and 13% by monoclonal antibody against CYP2B6 (MAB-2B6, P<0.05).	z-4-hydroxy-tamoxifen	52-73	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	190-196
12207635-1	2002	AIMS: To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen.	z-4-hydroxy-tamoxifen	164-185	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-110
12207635-7	2002	Furthermore, Z-4-hydroxy-tamoxifen formation significantly correlated with both CYP2C9 expression (r(s)=0.256, P<0.05) and CYP2D6 expression (r(s)=0.309, P<0.05).	z-4-hydroxy-tamoxifen	13-34	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	80-86
12207635-7	2002	Furthermore, Z-4-hydroxy-tamoxifen formation significantly correlated with both CYP2C9 expression (r(s)=0.256, P<0.05) and CYP2D6 expression (r(s)=0.309, P<0.05).	z-4-hydroxy-tamoxifen	13-34	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	126-132
12207635-9	2002	CYP2D6 and CYP2C9 contribute on average 45 and 46%, respectively, to the overall formation of Z-4-hydroxy-tamoxifen.	z-4-hydroxy-tamoxifen	94-115	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
12207635-2	2002	METHODS: The formation of Z-4-hydroxy-tamoxifen from 10 microm tamoxifen was studied in human liver microsomes (n=50), characterized for CYP2B6, CYP2C9, CYP2D6 and CYP3A4 expression, and CYP2B6, CYP2C9 and CYP2D6 genotype.	z-4-hydroxy-tamoxifen	26-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	137-143
12207635-9	2002	CYP2D6 and CYP2C9 contribute on average 45 and 46%, respectively, to the overall formation of Z-4-hydroxy-tamoxifen.	z-4-hydroxy-tamoxifen	94-115	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	11-17
12207635-2	2002	METHODS: The formation of Z-4-hydroxy-tamoxifen from 10 microm tamoxifen was studied in human liver microsomes (n=50), characterized for CYP2B6, CYP2C9, CYP2D6 and CYP3A4 expression, and CYP2B6, CYP2C9 and CYP2D6 genotype.	z-4-hydroxy-tamoxifen	26-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	187-193
12207635-10	2002	CONCLUSIONS: CYP2B6, CYP2C9 and CYP2D6 genotypes all affected Z-4-hydroxy-tamoxifen formation and can predict individual ability to catalyse this reaction.	z-4-hydroxy-tamoxifen	62-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	13-19
12207635-10	2002	CONCLUSIONS: CYP2B6, CYP2C9 and CYP2D6 genotypes all affected Z-4-hydroxy-tamoxifen formation and can predict individual ability to catalyse this reaction.	z-4-hydroxy-tamoxifen	62-83	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	21-27
12207635-2	2002	METHODS: The formation of Z-4-hydroxy-tamoxifen from 10 microm tamoxifen was studied in human liver microsomes (n=50), characterized for CYP2B6, CYP2C9, CYP2D6 and CYP3A4 expression, and CYP2B6, CYP2C9 and CYP2D6 genotype.	z-4-hydroxy-tamoxifen	26-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	195-201
12207635-10	2002	CONCLUSIONS: CYP2B6, CYP2C9 and CYP2D6 genotypes all affected Z-4-hydroxy-tamoxifen formation and can predict individual ability to catalyse this reaction.	z-4-hydroxy-tamoxifen	62-83	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38
12207635-2	2002	METHODS: The formation of Z-4-hydroxy-tamoxifen from 10 microm tamoxifen was studied in human liver microsomes (n=50), characterized for CYP2B6, CYP2C9, CYP2D6 and CYP3A4 expression, and CYP2B6, CYP2C9 and CYP2D6 genotype.	z-4-hydroxy-tamoxifen	26-47	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	206-212