PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2697748-4	1989	A plot of the permeability coefficient for sulphite, derived from Woolf-Eadie plots, against the degree of unsaturation in phospholipids (expressed as delta mol-1 value) showed that the coefficient was greater the lower the degree of unsaturation in the phospholipids.	Sulfites	43-51	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	157-162
35098465-5	2022	It was for the first time reported in this study that sulfite could effectively inhibit arylsulfatase, and its IC50 values for the snail- and human urine-derived arylsulfatase were determined to be 71.9 and 142.8 microM, which were lower than the concentration of sulfite in some healthy population.	Sulfites	54-61	snail family transcriptional repressor 1	Homo sapiens	131-136
35098465-5	2022	It was for the first time reported in this study that sulfite could effectively inhibit arylsulfatase, and its IC50 values for the snail- and human urine-derived arylsulfatase were determined to be 71.9 and 142.8 microM, which were lower than the concentration of sulfite in some healthy population.	Sulfites	264-271	snail family transcriptional repressor 1	Homo sapiens	131-136
2818640-2	1989	The reactivities of sulfite (SO23-) with DNA in the presence of metal ions were investigated by a DNA sequencing technique using 32P-labeled DNA fragments obtained from human c-Ha-ras-1 protooncogene.	Sulfites	20-27	HRas proto-oncogene, GTPase	Homo sapiens	175-185
35120924-1	2022	Sulfite oxidase (SOX) is a homodimeric molybdo-heme enzyme that oxidizes sulfite to sulfate at the molybdenum center.	Sulfites	73-80	sulfite oxidase	Homo sapiens	0-15
35120924-1	2022	Sulfite oxidase (SOX) is a homodimeric molybdo-heme enzyme that oxidizes sulfite to sulfate at the molybdenum center.	Sulfites	73-80	sulfite oxidase	Homo sapiens	17-20
35120924-4	2022	To address whether one subunit in a SOX dimer is sufficient for catalysis, we produced heterodimeric SOX variants with abolished sulfite oxidation by replacing the molybdenum-coordinating and essential cysteine in the active site.	Sulfites	129-136	sulfite oxidase	Homo sapiens	101-104
3556020-9	1987	Sulfite metabolism and the role of sulfite oxidase in the detoxification of exogenous sulfite are reviewed in relationship to the etiology of sulfite hypersensitivity.	Sulfites	86-93	sulfite oxidase	Homo sapiens	35-50
2832163-2	1988	The mitochondrial enzyme sulfite oxidase catalyzes the oxidation of cytochrome c by sulfite.	Sulfites	25-32	cytochrome c, somatic	Gallus gallus	68-80
3404287-1	1988	Sulfite oxidase catalyzes the oxidation of sulfite to sulfate.	Sulfites	43-50	sulfite oxidase	Rattus norvegicus	0-15
3694707-3	1987	SOD and catalase activities were most sensitive to sulfide (S2-), followed by sulfite (SO3(2-)) and sulfate (SO4(2-)).	Sulfites	78-85	catalase	Bos taurus	8-16
3657521-0	1987	Sulfite determination: sulfite oxidase.	Sulfites	0-7	sulfite oxidase	Homo sapiens	23-38
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfites	99-106	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfites	99-106	CD59 molecule (CD59 blood group)	Homo sapiens	269-274
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfites	248-255	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfites	248-255	CD59 molecule (CD59 blood group)	Homo sapiens	269-274
3019695-2	1986	Oxidation of sulfite to sulfate by sulfite oxidase is inhibited when the enzyme is treated with reagents known to modify imidazole and carboxyl groups.	Sulfites	13-20	sulfite oxidase	Gallus gallus	35-50
3019695-3	1986	Modification inhibits the oxidation of sulfite by the physiological electron acceptor cytochrome c, but not by the artificial acceptor ferricyanide.	Sulfites	39-46	cytochrome c, somatic	Gallus gallus	86-98
2879581-6	1986	Arylsulfatase A was inhibited by sulfate, sulfite, silver, magnesium, manganese and calcium ions and arylsulfatase B by chloride, sulfate, sulfite and silver ions.	Sulfites	42-49	arylsulfatase A	Equus caballus	0-15
2879581-6	1986	Arylsulfatase A was inhibited by sulfate, sulfite, silver, magnesium, manganese and calcium ions and arylsulfatase B by chloride, sulfate, sulfite and silver ions.	Sulfites	139-146	arylsulfatase A	Equus caballus	0-15
2879581-6	1986	Arylsulfatase A was inhibited by sulfate, sulfite, silver, magnesium, manganese and calcium ions and arylsulfatase B by chloride, sulfate, sulfite and silver ions.	Sulfites	139-146	arylsulfatase B	Equus caballus	101-116
4016147-9	1985	Therefore, the activity of the "sulfite-detoxifying enzyme" sulfite oxidase and the sensitivity of the energy metabolism to sulfite show a reciprocal relationship in the tissues and cells studied.	Sulfites	32-39	sulfite oxidase	Homo sapiens	60-75
2867782-4	1986	(1) Bicarbonate and sulfite activated solubilized lysosomal H+-ATPase, but not the membrane-bound ATPase or ATPase incorporated into liposomes.	Sulfites	20-27	dynein axonemal heavy chain 8	Homo sapiens	60-69
2867782-4	1986	(1) Bicarbonate and sulfite activated solubilized lysosomal H+-ATPase, but not the membrane-bound ATPase or ATPase incorporated into liposomes.	Sulfites	20-27	dynein axonemal heavy chain 8	Homo sapiens	63-69
4016147-0	1985	Effect of sulfite on the energy metabolism of mammalian tissues in correlation to sulfite oxidase activity.	Sulfites	10-17	sulfite oxidase	Homo sapiens	82-97
6226318-4	1983	The Arrhenius plots for ATPase revealed bends at 20 degrees and 30 degrees C in the presence of sulphite, chlorine, thiocyanate, glycerol and methanol.	Sulfites	96-104	dynein, axonemal, heavy chain 8	Mus musculus	24-30
3919502-1	1985	A case of combined deficiency of sulphite-oxidase and xanthine-oxidase with a defect of the molybdenum cofactor, which is vital to the activity of sulphite-, xanthine- and aldehyde-oxidase, is reported here.	Sulfites	33-41	aldehyde oxidase 1	Homo sapiens	172-188
6226318-3	1983	Glycerol-induced inhibition of ATPase was competitive with respect to sulphite; methanol competed with thiocyanate for the enzyme activity.	Sulfites	70-78	dynein, axonemal, heavy chain 8	Mus musculus	31-37
3836241-2	1985	Oxidation of hemoglobin to methemoglobin under aerobic conditions is induced by nitrite, catalyzed by methemoglobin in the presence of hydrogen peroxide, and inhibited by chemical reagents ranging from cysteine and ascorbic acid to sulfite.	Sulfites	232-239	hemoglobin subunit gamma 2	Homo sapiens	27-40
6334642-0	1984	Alpha-1-antitrypsin types and pulmonary disease among employees at a sulphite pulp factory in northern Sweden.	Sulfites	69-77	serpin family A member 1	Homo sapiens	0-19
16662848-4	1983	Light activation of phosphoenolpyruvate carboxylase and NADP-malate dehydrogenase was completely diminished when the epidermal strips were incubated for 2 hours in light with either sulfite or arsenite at 10 micromolar.	Sulfites	182-189	phosphoenolpyruvate carboxykinase 1	Homo sapiens	20-51
6136504-5	1983	119, 553-557) destroys the ability of D-amino acid oxidase to stabilize the benzoquinoid type spectrum of 8-mercapto-FAD and destroys the ability to form a flavin N-5 adduct with sulfite.	Sulfites	179-186	D-amino acid oxidase	Homo sapiens	38-58
6219716-6	1983	It was assumed that the anions control the rate of the limiting step of the ATPase reaction, since sulfite and thiocyanate change the activation energy of ATP hydrolysis.	Sulfites	99-106	dynein, axonemal, heavy chain 8	Mus musculus	76-82
6220498-1	1983	The nuclei of the rat liver, heart, thymus and of the mouse liver isolated in sucrose gradient reveal ATPase sensitive to bicarbonate, sulfite, azide and thiocyanate.	Sulfites	135-142	dynein, axonemal, heavy chain 8	Mus musculus	102-108
7219240-2	1981	Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion.	Sulfites	83-90	sulfite oxidase	Homo sapiens	0-15
7044114-4	1980	Hydrated SO2 forms bisulfite and sulfite ions, which are rapidly oxidized (detoxified) by sulfite oxidase, an enzyme, to form sulfate.	Sulfites	21-28	sulfite oxidase, mitochondrial	Cavia porcellus	90-105
7219240-0	1981	Sulfite oxidase deficiency: a high risk factor in SO2, sulfite, and bisulfite toxicity?	Sulfites	55-62	sulfite oxidase	Homo sapiens	0-15
6067894-1	1967	Insulin iodination interferes with the ability of the interchain S.S bonds to react with sulphite at pH7.	Sulfites	89-97	insulin	Homo sapiens	0-7
9389-7	1976	Kinetic studies on the reduction of the heme and tungsten centers of sulfite oxidase have shown that reduction of de-molybdo forms of sulfite oxidase by sulfite is catalyzed by the residual traces of native molybdenum-containing molecules.	Sulfites	69-76	sulfite oxidase	Rattus norvegicus	134-149
8450-2	1976	The reaction of sulfite, cyanide, and hydroxylamine with several deazaflavin-containing enzymes (glycolate oxidase, D-amino acid oxidase, glucose oxidase, N-methylglutamate synthetase) and free deazaFMN has been examined.	Sulfites	16-23	hydroxyacid oxidase 2	Homo sapiens	97-114
8450-2	1976	The reaction of sulfite, cyanide, and hydroxylamine with several deazaflavin-containing enzymes (glycolate oxidase, D-amino acid oxidase, glucose oxidase, N-methylglutamate synthetase) and free deazaFMN has been examined.	Sulfites	16-23	D-amino acid oxidase	Homo sapiens	116-136
8450-7	1976	The relative stability observed for the sulfite and cyanide complexes formed with various deazaflavin systems (glycolate oxidase greater than D-amino acid oxidase greater than free deazaFMN) follows the same trend observed for the stability of the sulfite complexes formed with the corresponding flavin system.	Sulfites	40-47	hydroxyacid oxidase 2	Homo sapiens	111-128
8450-7	1976	The relative stability observed for the sulfite and cyanide complexes formed with various deazaflavin systems (glycolate oxidase greater than D-amino acid oxidase greater than free deazaFMN) follows the same trend observed for the stability of the sulfite complexes formed with the corresponding flavin system.	Sulfites	40-47	D-amino acid oxidase	Homo sapiens	142-162
1173484-12	1975	Sulphite liberated 64 percent of the 35-S bound to thyroglobulin which appeared as four compounds on thin layer chromatography plates.	Sulfites	0-8	thyroglobulin	Rattus norvegicus	51-64
14956-2	1977	Treatment of rat liver sulfite oxidase with trypsin leads to loss of ability to oxidize sulfite in the presence of cytochrome c as electron acceptor.	Sulfites	23-30	cytochrome c	Sus scrofa	115-127
823969-3	1976	Enzymatic activity is optimum through the pH range 7-9 (37 degrees C) and can be inhibited by disodium ethylenediaminetetraacetate, N-ethylmaleimide, sulfite, soybean trypsin inhibitor and human alpha-1-antitrypsin.	Sulfites	150-157	serpin family A member 1	Homo sapiens	195-214
8450-7	1976	The relative stability observed for the sulfite and cyanide complexes formed with various deazaflavin systems (glycolate oxidase greater than D-amino acid oxidase greater than free deazaFMN) follows the same trend observed for the stability of the sulfite complexes formed with the corresponding flavin system.	Sulfites	248-255	hydroxyacid oxidase 2	Homo sapiens	111-128
8450-7	1976	The relative stability observed for the sulfite and cyanide complexes formed with various deazaflavin systems (glycolate oxidase greater than D-amino acid oxidase greater than free deazaFMN) follows the same trend observed for the stability of the sulfite complexes formed with the corresponding flavin system.	Sulfites	248-255	D-amino acid oxidase	Homo sapiens	142-162
1253452-0	1976	The sulphite precipitation method for fibrinogen measurement; its use on small samples in the presence of fibrinogen degradation products.	Sulfites	4-12	fibrinogen beta chain	Homo sapiens	38-48
1253452-0	1976	The sulphite precipitation method for fibrinogen measurement; its use on small samples in the presence of fibrinogen degradation products.	Sulfites	4-12	fibrinogen beta chain	Homo sapiens	106-116
1253452-3	1976	Measurements made with the sulphite technique on fibrinogen solutions on plasma samples were not significantly different from those obtained with the thrombin-clotting method.	Sulfites	27-35	fibrinogen beta chain	Homo sapiens	49-59
4154781-0	1974	Malate dehydrogenase in Zea mays: properties and inhibition by sulfite.	Sulfites	63-70	LOC100856934	Zea mays	0-20
33271457-7	2021	We found that the cytosolic isoform GOT1 is primarily responsible for the production of sulfite.	Sulfites	88-95	glutamic-oxaloacetic transaminase 1	Homo sapiens	36-40
4601437-1	1974	A UV-induced sulphite-requiring mutant (sD50) consistently shows mitotic linkage to groups I and VIII in haploids from heterozygous mapping diploids.	Sulfites	13-21	cytochrome c oxidase subunit 8A	Homo sapiens	97-101
33271457-2	2021	Sulfite oxidase is catalyzing the terminal reaction of cellular cysteine catabolism, the oxidation of sulfite to sulfate.	Sulfites	102-109	sulfite oxidase	Homo sapiens	0-15
33922196-5	2021	Although thiosulfate was converted to sulfite and H2S by the mitochondrial rhodanese Rdl1, its toxicity was not due to H2S as the rdl1-deletion mutant that produced significantly less H2S was more sensitive to thiosulfate than the wild type.	Sulfites	38-45	thiosulfate sulfurtransferase RDL1	Saccharomyces cerevisiae S288C	85-89
33360936-0	2021	Fabrication of Bi1.81MnNbO6.72/sulfite system for efficient degradation of chlortetracycline.	Sulfites	31-38	transmembrane BAX inhibitor motif containing 6	Homo sapiens	15-18
33360936-1	2021	The design of eco-friendly Bi1.81MnNbO6.72/sulfite system for efficient degradation of chlortetracycline was achieved.	Sulfites	43-50	transmembrane BAX inhibitor motif containing 6	Homo sapiens	27-30
33360936-9	2021	Under optimal conditions, the efficiency of Bi1.81MnNbO6.72/sulfite system for degradation of chlortetracycline could reach 76.2%.	Sulfites	60-67	transmembrane BAX inhibitor motif containing 6	Homo sapiens	44-47
33360936-10	2021	Moreover, Mn (II) plays a key role in the initiation of the catalytic reaction in Bi1.81MnNbO6.72/sulfite process.	Sulfites	98-105	transmembrane BAX inhibitor motif containing 6	Homo sapiens	82-85
32882059-0	2021	The mitochondrial-targeted reactive species scavenger JP4-039 prevents sulfite-induced alterations in antioxidant defenses, energy transfer and cell death signaling in striatum of rats.	Sulfites	71-78	junctophilin 4	Rattus norvegicus	54-57
32882059-6	2021	Sulfite administration decreased reduced glutathione concentration and glutathione peroxidase, glucose-6-phosphate dehydrogenase, glutathione S-transferase, and glutathione reductase activities in striatal tissue.	Sulfites	0-7	glucose-6-phosphate dehydrogenase	Rattus norvegicus	95-128
32882059-6	2021	Sulfite administration decreased reduced glutathione concentration and glutathione peroxidase, glucose-6-phosphate dehydrogenase, glutathione S-transferase, and glutathione reductase activities in striatal tissue.	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	130-155
32882059-6	2021	Sulfite administration decreased reduced glutathione concentration and glutathione peroxidase, glucose-6-phosphate dehydrogenase, glutathione S-transferase, and glutathione reductase activities in striatal tissue.	Sulfites	0-7	glutathione-disulfide reductase	Rattus norvegicus	161-182
32882059-9	2021	Additionally, sulfite altered phosphorylation of MAPK by decreasing of p38 and increasing of ERK.	Sulfites	14-21	mitogen activated protein kinase 14	Rattus norvegicus	71-74
32882059-9	2021	Additionally, sulfite altered phosphorylation of MAPK by decreasing of p38 and increasing of ERK.	Sulfites	14-21	Eph receptor B1	Rattus norvegicus	93-96
32882059-10	2021	Sulfite further augmented the content of GSK-3beta, Bok and cleaved caspase-3, indicating increased apoptosis.	Sulfites	0-7	glycogen synthase kinase 3 alpha	Rattus norvegicus	41-50
32882059-10	2021	Sulfite further augmented the content of GSK-3beta, Bok and cleaved caspase-3, indicating increased apoptosis.	Sulfites	0-7	BCL2 family apoptosis regulator BOK	Rattus norvegicus	52-55
32882059-10	2021	Sulfite further augmented the content of GSK-3beta, Bok and cleaved caspase-3, indicating increased apoptosis.	Sulfites	0-7	caspase 3	Rattus norvegicus	68-77
32882059-12	2021	Intraperitoneal injection of JP4-039 before sulfite administration preserved activity of antioxidant enzymes and CK.	Sulfites	44-51	junctophilin 4	Rattus norvegicus	29-32
32882059-14	2021	In sum, oxidative stress and apoptosis induced by sulfite injection are prevented by JP4-039, identifying this molecule as a promising candidate for pharmacological treatment of SO-deficient patients.	Sulfites	50-57	junctophilin 4	Rattus norvegicus	85-88
32695077-2	2020	In enological Saccharomyces cerevisiae strains, CR involving the promoter region of the gene SSU1 lead to a higher sulfite tolerance by enhancing the SO2 efflux.	Sulfites	115-122	Ssu1p	Saccharomyces cerevisiae S288C	93-97
32936630-6	2020	The resulting radical undergoes C-S fragmentation to form SO2, which becomes hydrated to sulfite/bisulfite (S(IV)).	Sulfites	89-96	IV	Homo sapiens	108-113
33066491-1	2020	(1) Background: Molybdenum cofactor deficiency type B (MOCODB, #252160) is a rare autosomal recessive metabolic disorder characterized by intractable seizures of neonatal-onset, muscular spasticity, accompanying with hypouricemia, elevated urinary sulfite levels and craniofacial dysmorphism.	Sulfites	248-255	molybdenum cofactor synthesis 2	Homo sapiens	16-53
33066491-1	2020	(1) Background: Molybdenum cofactor deficiency type B (MOCODB, #252160) is a rare autosomal recessive metabolic disorder characterized by intractable seizures of neonatal-onset, muscular spasticity, accompanying with hypouricemia, elevated urinary sulfite levels and craniofacial dysmorphism.	Sulfites	248-255	molybdenum cofactor synthesis 2	Homo sapiens	55-61
32266981-2	2020	Sulfoquinovosyl diacylglycerol1 (AtSQD1) encodes a protein, which catalyzes uridine diphosphate glucose (UDPG) and sulfite (SO3 2- ) to UDP-sulfoquinovose, which is a key component in the sulfolipid biosynthetic pathway.	Sulfites	115-122	sulfoquinovosyldiacylglycerol 1	Arabidopsis thaliana	33-39
32695077-9	2020	Finally, the link between the nature of SSU1 promoter and the tolerance to sulfite was statistically validated in natural grape juice containing various SO2 concentrations.	Sulfites	75-82	Ssu1p	Saccharomyces cerevisiae S288C	40-44
32317090-6	2020	Detection of the methylation level of CDO1 in plasma by sulfite modification and quantitative real-time PCR.	Sulfites	56-63	cysteine dioxygenase type 1	Homo sapiens	38-42
31995773-2	2020	At pH 8.0, more than 80% of the recalcitrant organic contaminant iohexol (10 muM) can be removed within 2 min by the activation of sulfite (500 muM) with CuFe2O4MOF (0.1 g L-1).	Sulfites	131-138	latexin	Homo sapiens	77-80
31995773-2	2020	At pH 8.0, more than 80% of the recalcitrant organic contaminant iohexol (10 muM) can be removed within 2 min by the activation of sulfite (500 muM) with CuFe2O4MOF (0.1 g L-1).	Sulfites	131-138	latexin	Homo sapiens	144-147
31751299-8	2020	SUOX detoxifies the sulfites.	Sulfites	20-28	sulfite oxidase	Homo sapiens	0-4
32275133-6	2020	The high transient local temperature on the surface of ML-MoOx generated by the photothermal effect facilitates to impact the reaction velocity and feed the SuOx-like activity, while the generation of hot carriers which are suggested as predominant effects catalyzes the oxidation of sulfite to sulfate through significantly decreasing the activation energy for the SuOx-like reaction.	Sulfites	284-291	sulfite oxidase	Homo sapiens	157-161
32275133-6	2020	The high transient local temperature on the surface of ML-MoOx generated by the photothermal effect facilitates to impact the reaction velocity and feed the SuOx-like activity, while the generation of hot carriers which are suggested as predominant effects catalyzes the oxidation of sulfite to sulfate through significantly decreasing the activation energy for the SuOx-like reaction.	Sulfites	284-291	sulfite oxidase	Homo sapiens	366-370
31638329-4	2020	The involvement of autophagic and vacuolar functions in sulfite tolerance was further confirmed by pairwise competition using a newly constructed atg2-defective strain, as well as by showing induction of ATG8 expression by sulfite.	Sulfites	56-63	Atg2p	Saccharomyces cerevisiae S288C	146-150
31638329-7	2020	Finally, the involvement of the sulfite pump Ssu1 and the transcription factor Fzf1 in sulfite tolerance by Saccharomyces cerevisiae was confirmed; a result that validates the experimental approach used in this work.	Sulfites	87-94	Ssu1p	Saccharomyces cerevisiae S288C	45-49
31638329-7	2020	Finally, the involvement of the sulfite pump Ssu1 and the transcription factor Fzf1 in sulfite tolerance by Saccharomyces cerevisiae was confirmed; a result that validates the experimental approach used in this work.	Sulfites	87-94	Fzf1p	Saccharomyces cerevisiae S288C	79-83
31714892-11	2020	SUOX detoxifies sulfite from sulfur-containing amino acids.	Sulfites	16-23	sulfite oxidase	Homo sapiens	0-4
32026925-4	2020	Herein we construct a novel targeting mitochondria fluorescent probe CP-K based on the FRET mechanism to visualize sulfite in living MCF-7 cells.	Sulfites	115-122	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	69-73
31638329-4	2020	The involvement of autophagic and vacuolar functions in sulfite tolerance was further confirmed by pairwise competition using a newly constructed atg2-defective strain, as well as by showing induction of ATG8 expression by sulfite.	Sulfites	56-63	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	204-208
31638329-4	2020	The involvement of autophagic and vacuolar functions in sulfite tolerance was further confirmed by pairwise competition using a newly constructed atg2-defective strain, as well as by showing induction of ATG8 expression by sulfite.	Sulfites	223-230	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	204-208
31638329-7	2020	Finally, the involvement of the sulfite pump Ssu1 and the transcription factor Fzf1 in sulfite tolerance by Saccharomyces cerevisiae was confirmed; a result that validates the experimental approach used in this work.	Sulfites	32-39	Ssu1p	Saccharomyces cerevisiae S288C	45-49
31893496-3	2019	In the mitochondria, hydrogen sulfide is oxidized to sulfite, which is then converted to thiosulfate (sulfane sulfur-containing compound) by thiosulfate sulfurtransferase (rhodanese; TST).	Sulfites	53-60	thiosulfate sulfurtransferase	Rattus norvegicus	141-170
31893496-3	2019	In the mitochondria, hydrogen sulfide is oxidized to sulfite, which is then converted to thiosulfate (sulfane sulfur-containing compound) by thiosulfate sulfurtransferase (rhodanese; TST).	Sulfites	53-60	thiosulfate sulfurtransferase	Rattus norvegicus	183-186
31597378-2	2019	Adenosine 5"-phosphosulfate (APS) reductase (APR) plays a vital role in catalyzing the reduction of activated sulfate to sulfite, which requires glutathione.	Sulfites	121-128	APS reductase 1	Arabidopsis thaliana	0-43
31832424-2	2019	The molecular mechanisms by which Saccharomyces cerevisiae responds and tolerates SO2 have been mainly focused on the sulfite efflux pump encoded by SSU1.	Sulfites	118-125	Ssu1p	Saccharomyces cerevisiae S288C	149-153
31583830-1	2019	Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level.	Sulfites	89-96	sulfite oxidase	Homo sapiens	0-15
31583830-1	2019	Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level.	Sulfites	89-96	sulfite oxidase	Homo sapiens	17-21
31583830-1	2019	Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level.	Sulfites	148-155	sulfite oxidase	Homo sapiens	0-15
31583830-1	2019	Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level.	Sulfites	148-155	sulfite oxidase	Homo sapiens	17-21
31583830-6	2019	It is found that vitamin B1 (VB1) inhibits the SuOx mimic activity of P-MoO3 -x NPs through the irreversible cleavage by sulfite and the electrostatic interaction with P-MoO3 -x NPs.	Sulfites	121-128	sulfite oxidase	Homo sapiens	47-51
31597378-2	2019	Adenosine 5"-phosphosulfate (APS) reductase (APR) plays a vital role in catalyzing the reduction of activated sulfate to sulfite, which requires glutathione.	Sulfites	121-128	APS reductase 1	Arabidopsis thaliana	45-48
31799324-2	2019	Up to now the characterization of the molecular mechanisms by which S. cerevisiae responds and tolerates SO2 was focused on the role of the sulfite efflux pump Ssu1 and investigation on the involvement of other players has been scarce, especially at a genome-wide level.	Sulfites	140-147	Ssu1p	Saccharomyces cerevisiae S288C	160-164
31127934-1	2019	Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate.	Sulfites	127-134	sulfite oxidase	Homo sapiens	0-15
31356773-4	2019	Their transport properties and kinetic parameters demonstrate that UCP5 and UCP6 transport inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and (only UCP5) glutamate and tricarboxylates.	Sulfites	118-125	solute carrier family 25 member 14	Homo sapiens	67-71
31356773-8	2019	It is proposed that a main physiological role of UCP5 and UCP6 is to catalyze the export of sulfite and thiosulfate (the H2S degradation products) from the mitochondria, thereby modulating the level of the important signal molecule H2S.	Sulfites	92-99	solute carrier family 25 member 14	Homo sapiens	49-53
31127934-1	2019	Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate.	Sulfites	127-134	sulfite oxidase	Homo sapiens	17-19
31127934-1	2019	Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate.	Sulfites	127-134	sulfite oxidase	Homo sapiens	47-51
31127934-2	2019	Oxidation of sulfite is dependent on two cofactors within SO, a heme and the molybdenum cofactor (Moco), the latter forming the catalytic site of sulfite oxidation.	Sulfites	13-20	sulfite oxidase	Homo sapiens	58-60
31240657-0	2019	Efficient abatement of an iodinated X-ray contrast media iohexol by Co(II) or Cu(II) activated sulfite autoxidation process.	Sulfites	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
31465441-9	2019	To test the phenotypic impact of translocations, we first recapitulated in a lab strain the SSU1/ECM34 translocation providing increased sulphite resistance to wine isolates.	Sulfites	137-145	Ssu1p	Saccharomyces cerevisiae S288C	92-96
31465441-9	2019	To test the phenotypic impact of translocations, we first recapitulated in a lab strain the SSU1/ECM34 translocation providing increased sulphite resistance to wine isolates.	Sulfites	137-145	Ecm34p	Saccharomyces cerevisiae S288C	97-102
31465441-11	2019	However, adding the repeated sequences that are present in the SSU1 promoter of the resistant wine strain induced sulphite resistance in the lab strain, yet to a lower level than that of the wine isolate, implying that additional polymorphisms also contribute to the phenotype.	Sulfites	114-122	Ssu1p	Saccharomyces cerevisiae S288C	63-67
31240657-7	2019	Overall, activation of sulfite to produce reactive radicals with extremely low Co(II) or Cu(II) concentrations (in the range of mug L-1) in circumneutral conditions is confirmed, which offers a potential SO4 --based advanced oxidation process in treatment of aquatic organic contaminants.	Sulfites	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
31001109-1	2019	Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Homo sapiens	96-111
31002874-0	2019	Reciprocal regulation of sulfite oxidation and nitrite reduction by mitochondrial sulfite oxidase.	Sulfites	25-32	sulfite oxidase	Homo sapiens	82-97
31284569-3	2019	Our previous studies have shown that maize sulfite oxidase (SO) has a sulfite-oxidizing function and is involved in the drought stress response.	Sulfites	43-50	sulfite oxidase	Zea mays	60-62
31167903-4	2019	In the presence of the physiological electron acceptor cytochrome c, we were able to close the catalytic cycle of sulfite-dependent nitrite reduction thus leading to steady-state NO synthesis, a finding that strongly supports a physiological relevance of SO-dependent NO formation.	Sulfites	114-121	cytochrome c, somatic	Homo sapiens	55-67
31167903-4	2019	In the presence of the physiological electron acceptor cytochrome c, we were able to close the catalytic cycle of sulfite-dependent nitrite reduction thus leading to steady-state NO synthesis, a finding that strongly supports a physiological relevance of SO-dependent NO formation.	Sulfites	114-121	sulfite oxidase	Homo sapiens	255-257
31107239-6	2019	CDO1 silencing promotes proliferation of NSCLC by limiting the futile metabolism of cysteine to the wasteful and toxic byproducts CSA and sulfite (SO32-), and depletion of cellular NADPH.	Sulfites	138-145	cysteine dioxygenase type 1	Homo sapiens	0-4
30859719-4	2019	In wine yeast strains, two chromosomal translocations (VIIItXVI and XVtXVI) involving the SSU1 promoter region have been shown to upregulate SSU1 expression and, as a result, increase sulfite tolerance.	Sulfites	184-191	Ssu1p	Saccharomyces cerevisiae S288C	90-94
30859719-4	2019	In wine yeast strains, two chromosomal translocations (VIIItXVI and XVtXVI) involving the SSU1 promoter region have been shown to upregulate SSU1 expression and, as a result, increase sulfite tolerance.	Sulfites	184-191	Ssu1p	Saccharomyces cerevisiae S288C	141-145
31001109-1	2019	Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Homo sapiens	113-116
30447242-9	2019	Immunohistochemical analysis showed that sulfite ingestion caused an increase in the amount of hippocampal caspase-3 positive cells.	Sulfites	41-48	caspase 3	Rattus norvegicus	107-116
30577117-2	2019	Firstly, sulphides (0.5 g L-1) and sulphites (2.5 g L-1) were catalytic oxidised at natural pH (8.7).	Sulfites	35-44	L1 cell adhesion molecule	Homo sapiens	52-55
30577117-5	2019	Concentrations of sulphide and sulphite lower than 1.0 mg L-1 (emission limit value - ELV) were obtained after 5-h oxygenation or 1-min peroxidation under the best conditions, i.e. air flow rate of 1 Lair Lleachate-1 min-1 and H2O2:sulphur stoichiometric ratio.	Sulfites	31-39	L1 cell adhesion molecule	Homo sapiens	58-61
30447242-11	2019	cPLA2 might play a role in ingested sulfite-induced oxidative stress and apoptotic cell death in the hippocampus.	Sulfites	36-43	phospholipase A2 group IVA	Rattus norvegicus	0-5
30141069-3	2018	Recently, we have reported that many heterotrophic bacteria can use sulfide:quinone oxidoreductase and persulfide dioxygenase to oxidize H2S to thiosulfate and sulfite.	Sulfites	160-167	crystallin zeta	Homo sapiens	76-98
30498506-10	2018	The severe damage phenotypes of the ZmSiR-compromised maize plants were accompanied by increases of sulfite and H2O2 accumulations, but less amounts of GSH.	Sulfites	100-107	sulfite reductase [ferredoxin], chloroplastic	Zea mays	36-41
30498506-12	2018	Particularly, ZmAPR2 expression was significantly elevated, suggesting that toxic sulfite accumulation in ZmSiR-impaired plants could be attributable to the reduced SiR coupled to increased ZmAPR2 expression.	Sulfites	82-89	sulfite reductase [ferredoxin], chloroplastic	Zea mays	106-111
30498506-12	2018	Particularly, ZmAPR2 expression was significantly elevated, suggesting that toxic sulfite accumulation in ZmSiR-impaired plants could be attributable to the reduced SiR coupled to increased ZmAPR2 expression.	Sulfites	82-89	sulfite reductase [ferredoxin], chloroplastic	Zea mays	108-111
30103142-3	2018	In the presence of sulfate (1000 mg L-1), over 99% of Se(VI) (initially at 10 mg L-1) could be reduced by sulfite (5.0 mM) with a UV dose of 16 J cm-2 (within 20 min) into Se(IV) as the sole observed product.	Sulfites	106-113	immunoglobulin kappa variable 1-16	Homo sapiens	36-39
30103142-3	2018	In the presence of sulfate (1000 mg L-1), over 99% of Se(VI) (initially at 10 mg L-1) could be reduced by sulfite (5.0 mM) with a UV dose of 16 J cm-2 (within 20 min) into Se(IV) as the sole observed product.	Sulfites	106-113	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
30428991-5	2018	By the acidification process, a limit of detection of 7.7 muM by the proposed method was obtained for both sulfide and sulfite in aqueous medium, and this method was successfully utilized to analysis of real samples.	Sulfites	119-126	latexin	Homo sapiens	58-61
30362717-2	2018	ETHE1 dioxygenates glutathione persulfide (GSSH) to glutathione (GSH) and sulfite in a reaction which is similar to that of cysteine dioxygenase (CDO), but with monodentate (vs bidentate) substrate coordination and a 2-His/1-Asp (vs 3-His) ligand set.	Sulfites	74-81	ETHE1 persulfide dioxygenase	Homo sapiens	0-5
30217845-4	2018	Two rhodaneses, Rdl1 and Rdl2, converted thiosulfate to a persulfide and sulfite.	Sulfites	73-80	thiosulfate sulfurtransferase RDL1	Saccharomyces cerevisiae S288C	16-20
30217845-4	2018	Two rhodaneses, Rdl1 and Rdl2, converted thiosulfate to a persulfide and sulfite.	Sulfites	73-80	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	25-29
29310311-6	2018	This strategy allowed a procedure for the determination of sulfite with limits of detection and quantification of 0.36 and 1.21mgL-1 (for a sample volume of 10mL) and precision expressed as relative standard deviation of 5.4% and 6.4% for a coconut water sample containing 38.13 and 54.58mgL-1 of free and total sulfite, respectively.	Sulfites	59-66	LLGL scribble cell polarity complex component 1	Homo sapiens	127-132
30323799-7	2018	The generated sulfide was metabolized via sulfite and ultimately to sulfate mediated by reverse dissimilatory sulfite reductase, APS reductase, and sulfate adenylyltransferase and the released electrons were potentially transferred to the anode via soluble electron shuttles.	Sulfites	42-49	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	148-175
29980601-3	2018	Persulfide dioxygenase (PDO or ETHE1) is a mononuclear non-heme iron-containing protein in the sulfide oxidation pathway catalyzing the conversion of GSH persulfide (GSSH) to sulfite and GSH.	Sulfites	175-182	ETHE1 persulfide dioxygenase	Homo sapiens	31-36
29523891-3	2018	Using the Tara Oceans metagenomic dataset, we have identified draft genomes of nine bacteria that possess the genomic potential for anoxygenic phototrophy, carbon fixation via the Calvin-Benson-Bassham cycle, and the oxidation of sulfite and thiosulfate.	Sulfites	230-237	TRIO and F-actin binding protein	Homo sapiens	10-14
29549261-1	2018	Sulfite oxidase is a mononuclear molybdenum enzyme that oxidises sulfite to sulfate in many organisms, including man.	Sulfites	65-72	sulfite oxidase	Homo sapiens	0-15
28934687-4	2018	Specifically, when adding 5muM SCN into 100muM Cr(VI) + 600muM sulfite reaction system at pH 3.5, Cr(VI) reduction amount and [sulfite]oxidation/[Cr(VI)]reduction ratio value were approximately 2 and 0.45, respectively, times those in the SCN-free case.	Sulfites	63-70	latexin	Homo sapiens	27-30
29767695-6	2018	Sulfite oxidase, an enzyme found in mitochondria, catalyzes oxidation of sulfite to sulfate, the final step in oxidation of sulfur amino acids (cysteine and methionine).	Sulfites	73-80	sulfite oxidase	Homo sapiens	0-15
29306790-9	2018	The absence of radical formation in LPS-challenged MPO- or NADPH oxidase-knockout mice indicates that sulfite-derived radical formation is dependent on both MPO and NADPH oxidase activity.	Sulfites	102-109	myeloperoxidase	Mus musculus	157-160
29082888-9	2018	CONCLUSION: This study is the first one in the literature that shows the expression of mTOR signaling proteins in gastric mucosa of rats exposed to sulfite and ghrelin.	Sulfites	148-155	mechanistic target of rapamycin kinase	Rattus norvegicus	87-91
29082888-0	2018	Evaluation of mTOR signaling pathway proteins in rat gastric mucosa exposed to sulfite and ghrelin.	Sulfites	79-86	mechanistic target of rapamycin kinase	Rattus norvegicus	14-18
28231394-6	2017	FZF1 and SSU1, mostly known for conferring sulphite resistance in wine yeasts, were among the introgressed genes, although not fixed.	Sulfites	43-51	Fzf1p	Saccharomyces cerevisiae S288C	0-4
28777380-1	2017	Sulfide (H2S, HS- and S2-) oxidation to sulfite and thiosulfate by heterotrophic bacteria, using sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO), has recently been reported as a possible detoxification mechanism for sulfide at high levels.	Sulfites	40-47	quinone oxidoreductase	Pseudomonas aeruginosa PAO1	105-127
28529047-0	2017	Bezafibrate prevents mitochondrial dysfunction, antioxidant system disturbance, glial reactivity and neuronal damage induced by sulfite administration in striatum of rats: Implications for a possible therapeutic strategy for sulfite oxidase deficiency.	Sulfites	128-135	sulfite oxidase	Rattus norvegicus	225-240
28529047-1	2017	Sulfite accumulates in tissues of patients affected by sulfite oxidase (SO) deficiency, a neurometabolic disease characterized by seizures and progressive encephalopathy, often resulting in early death.	Sulfites	0-7	sulfite oxidase	Homo sapiens	55-70
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	glutathione-disulfide reductase	Rattus norvegicus	136-157
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	glutathione-disulfide reductase	Rattus norvegicus	159-161
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	164-189
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	191-194
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	glucose-6-phosphate dehydrogenase	Rattus norvegicus	200-233
28529047-6	2017	Sulfite also diminished cytochrome c oxidase (COX) IV-1 content, glutathione levels and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH).	Sulfites	0-7	glucose-6-phosphate dehydrogenase	Rattus norvegicus	235-240
28417315-7	2017	In addition, sulfite decreased the activities of glutathione peroxidase in all brain structures, of glutathione S-transferase in hippocampus and cerebellum, and of glutathione reductase in cerebellum.	Sulfites	13-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	100-125
28417315-7	2017	In addition, sulfite decreased the activities of glutathione peroxidase in all brain structures, of glutathione S-transferase in hippocampus and cerebellum, and of glutathione reductase in cerebellum.	Sulfites	13-20	glutathione-disulfide reductase	Rattus norvegicus	164-185
28910083-1	2017	Mercury re-emission, because of the reduction of Hg2+ to form Hg0 by sulfite, has become a great concern in the desulfurization process.	Sulfites	69-76	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	49-52
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Sulfites	343-350	cell adhesion associated, oncogene regulated	Homo sapiens	30-33
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Sulfites	343-350	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
28231394-6	2017	FZF1 and SSU1, mostly known for conferring sulphite resistance in wine yeasts, were among the introgressed genes, although not fixed.	Sulfites	43-51	Ssu1p	Saccharomyces cerevisiae S288C	9-13
28461726-1	2017	Sulfite oxidase (SOX) is a crucial molybdenum cofactor-containing enzyme in plants that re-oxidizes the sulfite back to sulfate in sulfite assimilation pathway.	Sulfites	131-138	sulfite oxidase	Brachypodium distachyon	17-20
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	13-20	sulfite oxidase	Brachypodium distachyon	9-12
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	13-20	sulfite oxidase	Brachypodium distachyon	107-110
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	13-20	sulfite oxidase	Brachypodium distachyon	107-110
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	111-118	sulfite oxidase	Brachypodium distachyon	9-12
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	111-118	sulfite oxidase	Brachypodium distachyon	107-110
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Sulfites	111-118	sulfite oxidase	Brachypodium distachyon	107-110
28266552-5	2017	Furthermore, overexpression of the SSU1 gene, which encodes for a transporter that confers resistance to sulphites, provides an ecological advantage to the dominant strain.	Sulfites	105-114	Ssu1p	Saccharomyces cerevisiae S288C	35-39
27692161-5	2016	Sulfite oxidase, a molybdenum-containing enzyme, catalyzes oxidation of sulfite to sulfate, which can then be excreted or reused by the body.	Sulfites	72-79	sulfite oxidase	Homo sapiens	0-15
28461726-1	2017	Sulfite oxidase (SOX) is a crucial molybdenum cofactor-containing enzyme in plants that re-oxidizes the sulfite back to sulfate in sulfite assimilation pathway.	Sulfites	104-111	sulfite oxidase	Brachypodium distachyon	0-15
28461726-1	2017	Sulfite oxidase (SOX) is a crucial molybdenum cofactor-containing enzyme in plants that re-oxidizes the sulfite back to sulfate in sulfite assimilation pathway.	Sulfites	104-111	sulfite oxidase	Brachypodium distachyon	17-20
28461726-1	2017	Sulfite oxidase (SOX) is a crucial molybdenum cofactor-containing enzyme in plants that re-oxidizes the sulfite back to sulfate in sulfite assimilation pathway.	Sulfites	131-138	sulfite oxidase	Brachypodium distachyon	0-15
27837805-5	2017	The ratio of fluorescence intensity at 488nm and 630nm (I488/I630) was linear with sulfite concentration over the range of 0-80muM with a detection limit of 0.23muM.	Sulfites	83-90	latexin	Homo sapiens	127-130
27523630-1	2016	Patients affected by sulfite oxidase (SO) deficiency present severe seizures early in infancy and progressive neurological damage, as well as tissue accumulation of sulfite, thiosulfate and S-sulfocysteine.	Sulfites	21-28	sulfite oxidase	Rattus norvegicus	38-40
27523630-5	2016	Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats.	Sulfites	0-7	glutathione-disulfide reductase	Rattus norvegicus	75-96
27523630-5	2016	Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats.	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	101-126
27523630-5	2016	Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats.	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	128-131
27523630-5	2016	Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats.	Sulfites	0-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	159-162
27523630-5	2016	Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats.	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	180-182
27523630-6	2016	Moreover, sulfite increased the activities of complexes II and II-III in striatum and of complex II in hippocampus, but reduced the activity of complex IV in striatum of SO-deficient rats.	Sulfites	10-17	sulfite oxidase	Rattus norvegicus	170-172
27523630-8	2016	Finally, sulfite inhibited the activities of malate and glutamate dehydrogenase in cerebral cortex of SO-deficient rats.	Sulfites	9-16	sulfite oxidase	Rattus norvegicus	102-104
28735401-0	2017	Determination of Enzymes Associated with Sulfite Toxicity in Plants: Kinetic Assays for SO, APR, SiR, and In-Gel SiR Activity.	Sulfites	41-48	sulfite oxidase	Homo sapiens	88-90
28735401-0	2017	Determination of Enzymes Associated with Sulfite Toxicity in Plants: Kinetic Assays for SO, APR, SiR, and In-Gel SiR Activity.	Sulfites	41-48	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	92-95
28735401-3	2017	Cysteine is generated by the sulfate reductive pathway where sulfite oxidase (SO; EC 1.8.3.1) is an important enzyme in the homeostasis of sulfite levels (present either as a toxic intermediate in the pathway or as a toxic air pollutant that has penetrated the plant tissue via the stomata).	Sulfites	61-68	sulfite oxidase	Homo sapiens	78-80
28735401-4	2017	SO is localized to the peroxisomes and detoxifies excess sulfite by catalyzing its oxidation to sulfate.	Sulfites	57-64	sulfite oxidase	Homo sapiens	0-2
28735401-9	2017	Here we present two robust, sensitive, and simple colorimetric methods of APR activity based on sulfite determination by fuchsin.Sulfite reductase (SiR) is one of the key enzymes in the primary sulfur assimilation pathway.	Sulfites	96-103	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	74-77
28735401-12	2017	Sulfite-generating ST activity is determined by colorimetric detection of SCN- formation at 460 nm as the red Fe(SCN)3 complex from cyanide and thiosulfate using acidic iron reagent.	Sulfites	0-7	HCLS1 associated protein X-1	Homo sapiens	113-118
28735402-4	2017	Sulfate and sulfite are, respectively, the precursor and intermediate for cysteine biosynthesis and there is evidence for stress-induced sulfate uptake and further downstream, enhanced sulfite generation by 5"-phosphosulfate (APS) reductase (APR, EC 1.8.99.2) activity.	Sulfites	12-19	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	242-245
27994615-6	2016	The severe damage phenotypes of the SiR-impaired lines were accompanied by increases of hydrogen peroxide (H2O2), malondialdehyde (MDA), and sulfite accumulations, but less amounts of glutathione (GSH).	Sulfites	141-148	sulfite reductase	Arabidopsis thaliana	36-39
27994615-10	2016	Together, our results indicate that SiR is involved in oxidative stress tolerance possibly by maintaining sulfite homeostasis, regulating GSH levels, and modulating sulfite metabolism-related gene expression in Arabidopsis.	Sulfites	106-113	sulfite reductase	Arabidopsis thaliana	36-39
24506486-9	2016	Sulfite is oxidized to sulfate by sulfite oxidase, this enzyme is determinant in sulfate synthesis, and it is absent in many mesophiles.	Sulfites	0-7	sulfite oxidase	Homo sapiens	34-49
27260448-0	2016	A sensitive and selective on-line amperometric sulfite biosensor using sulfite oxidase immobilized on a magnetite-gold-folate nanocomposite modified carbon-paste electrode.	Sulfites	47-54	sulfite oxidase	Homo sapiens	71-86
27260448-1	2016	We describe a novel amperometric sulfite biosensor, comprising a carbon-paste electrode (Fe3O4@Au-Cys-FA/CPE) modified with immobilized sulfite oxidase (SOx) on a gold-coated magnetite nanoparticle core, encased within a conjugated folic acid (FA) cysteine (Cys) shell.	Sulfites	33-40	sulfite oxidase	Homo sapiens	136-151
27260448-1	2016	We describe a novel amperometric sulfite biosensor, comprising a carbon-paste electrode (Fe3O4@Au-Cys-FA/CPE) modified with immobilized sulfite oxidase (SOx) on a gold-coated magnetite nanoparticle core, encased within a conjugated folic acid (FA) cysteine (Cys) shell.	Sulfites	33-40	sulfite oxidase	Homo sapiens	153-156
27455890-2	2016	To confirm this hypothesis, a sulfite-reducing up-flow anaerobic sludge blanket reactor was set up to treat FGD wastewater at metal loading rates of 9.2 g/m(3)-d Pb(II) and 2.6 g/m(3)-d Hg(II) for 50 days.	Sulfites	30-37	submaxillary gland androgen regulated protein 3B	Homo sapiens	162-168
27105581-5	2016	After transamination to 3-mercaptopyruvate, the sulfhydryl group from l-cysteine is transferred to glutathione by sulfurtransferase 1 and oxidized to sulfite by the sulfur dioxygenase ETHE1.	Sulfites	150-157	glyoxalase II 3	Arabidopsis thaliana	184-189
27105581-6	2016	Sulfite is then converted to thiosulfate by addition of a second persulfide group by sulfurtransferase 1.	Sulfites	0-7	mercaptopyruvate sulfurtransferase 1	Arabidopsis thaliana	85-104
25342669-1	2016	Sulfite, commonly used as a preservative in foods, beverages, and pharmaceuticals, is a very reactive and potentially toxic molecule which is detoxified by sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	156-171
25342669-1	2016	Sulfite, commonly used as a preservative in foods, beverages, and pharmaceuticals, is a very reactive and potentially toxic molecule which is detoxified by sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	173-176
26841230-8	2016	The nitrate and sulfite induced indirect TOX photolysis rates were less than 50% of the direct photolysis rates under the conditions of this study.	Sulfites	16-23	thymocyte selection associated high mobility group box	Homo sapiens	41-44
26709389-9	2016	Studies were performed to understand the related mechanism of oxidation of sulfite and radical generation by ferric cytochrome c (Fe3+ cyt c) in the absence and presence of H2O2.	Sulfites	75-82	cytochrome c, somatic	Homo sapiens	116-128
26709389-9	2016	Studies were performed to understand the related mechanism of oxidation of sulfite and radical generation by ferric cytochrome c (Fe3+ cyt c) in the absence and presence of H2O2.	Sulfites	75-82	cytochrome c, somatic	Homo sapiens	135-140
26709389-12	2016	The amount of DMPO-SO3- formed from the oxidation of sulfite by the Fe3+ cyt c increased with sulfite concentration.	Sulfites	53-60	cytochrome c, somatic	Homo sapiens	73-78
26709389-12	2016	The amount of DMPO-SO3- formed from the oxidation of sulfite by the Fe3+ cyt c increased with sulfite concentration.	Sulfites	94-101	cytochrome c, somatic	Homo sapiens	73-78
26709389-13	2016	In addition, the amount of DMPO-SO3- formed by the peroxidase activity of Fe3+ cyt c also increased with sulfite and H2O2 concentration.	Sulfites	105-112	cytochrome c, somatic	Homo sapiens	79-84
26709389-14	2016	From these results, we propose a mechanism in which the Fe3+ cyt c and its peroxidase activity oxidizes sulfite to sulfite radical.	Sulfites	104-111	cytochrome c, somatic	Homo sapiens	61-66
26709389-15	2016	Our results suggest that Fe3+ cyt c could have a novel role in the deleterious effects of sulfite in biological systems due to increased production of sulfite radical.	Sulfites	90-97	cytochrome c, somatic	Homo sapiens	30-35
27590555-3	2016	In this paper, a FRET-based two-photon fluorescent turn-on probe, A-HCy, was proposed for specific detection of SO2 derivatives through the bisulfite/sulfite-promoted Michael addition reaction.	Sulfites	142-149	adenosylhomocysteinase	Homo sapiens	66-71
26680199-4	2015	Using in vitro assays with an archaeal DsrAB, supported with genetic experiments in a bacterial system, we show that the product of sulfite reduction by DsrAB is a protein-based trisulfide, in which a sulfite-derived sulfur is bridging two conserved cysteines of DsrC.	Sulfites	132-139	phosphatidylinositol glycan anchor biosynthesis class P	Homo sapiens	263-267
26506573-0	2015	Investigation of the effects of a sulfite molecule on human neuroblastoma cells via a novel oncogene URG4/URGCP.	Sulfites	34-41	upregulator of cell proliferation	Homo sapiens	101-105
26506573-0	2015	Investigation of the effects of a sulfite molecule on human neuroblastoma cells via a novel oncogene URG4/URGCP.	Sulfites	34-41	upregulator of cell proliferation	Homo sapiens	106-111
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	upregulator of cell proliferation	Homo sapiens	125-129
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	upregulator of cell proliferation	Homo sapiens	130-135
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	cyclin D1	Homo sapiens	139-144
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	cyclin dependent kinase 4	Homo sapiens	146-150
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	cyclin dependent kinase 6	Homo sapiens	152-156
26269602-2	2015	Rhodanese catalyzes the transfer of sulfane sulfur from glutathione persulfide (GSSH) to sulfite generating thiosulfate and from thiosulfate to cyanide generating thiocyanate.	Sulfites	89-96	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	0-9
26357959-1	2015	The bioelectrocatalytic sulfite oxidation by human sulfite oxidase (hSO) on indium tin oxide (ITO) is reported, which is facilitated by functionalizing of the electrode surface with polyethylenimine (PEI)-entrapped CdS nanoparticles and enzyme.	Sulfites	24-31	CDP-diacylglycerol synthase 1	Homo sapiens	215-218
26000553-5	2015	Furthermore, we report genetic evidence suggestive of sulfite and/or organosulfonate reduction by Thermoplasmata Bg1.	Sulfites	54-61	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	113-116
28793693-2	2015	In this study, palladium catalysts supported on titanium suboxides (Pd/TinO2n-1) were prepared by the sulphite complex route.	Sulfites	102-110	mex-3 RNA binding family member D	Homo sapiens	71-75
26357959-8	2015	Moreover, for the first time a photoelectrochemical electrode involving immobilized hSO is demonstrated where photoexcitation of the CdS/hSO-modified electrode lead to an enhanced generation of bioelectrocatalytic currents upon sulfite addition.	Sulfites	228-235	CDP-diacylglycerol synthase 1	Homo sapiens	133-136
26269602-8	2015	All three rhodanese forms preferentially catalyze sulfur transfer from GSSH to sulfite, generating thiosulfate and glutathione.	Sulfites	79-86	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	10-19
26269602-9	2015	The kcat/Km,sulfite values for the variants in the sulfur transfer reaction from GSSH to sulfite were 1.6- (Asp-102) and 4-fold (Ala-285) lower than for wild-type rhodanese, whereas the kcat/Km,GSSH values were similar for all three enzymes.	Sulfites	12-19	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	163-172
26269602-9	2015	The kcat/Km,sulfite values for the variants in the sulfur transfer reaction from GSSH to sulfite were 1.6- (Asp-102) and 4-fold (Ala-285) lower than for wild-type rhodanese, whereas the kcat/Km,GSSH values were similar for all three enzymes.	Sulfites	89-96	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	163-172
26269602-11	2015	Our studies show that polymorphic variations that are distant from the active site differentially modulate the sulfurtransferase activity of human rhodanese to cyanide versus sulfite and might be important in differences in susceptibility to diseases where rhodanese dysfunction has been implicated, e.g. inflammatory bowel diseases.	Sulfites	175-182	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	147-156
26269602-11	2015	Our studies show that polymorphic variations that are distant from the active site differentially modulate the sulfurtransferase activity of human rhodanese to cyanide versus sulfite and might be important in differences in susceptibility to diseases where rhodanese dysfunction has been implicated, e.g. inflammatory bowel diseases.	Sulfites	175-182	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	257-266
26177047-5	2015	In the presence of molecular oxygen (O2), hETHE1 oxidizes glutathione persulfide (GSSH) to generate sulfite and reduced glutathione.	Sulfites	100-107	ETHE1 persulfide dioxygenase	Homo sapiens	42-48
24694040-3	2015	This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods.	Sulfites	51-58	complement factor properdin	Mus musculus	105-109
24694040-13	2015	DISCUSSION: The sulfite-induced structural changes in mPFC and curcumin had a protective role against the changes in the rats.	Sulfites	16-23	complement factor properdin	Mus musculus	54-58
26177047-6	2015	In contrast, CstB oxidizes major cellular low molecular weight (LMW) persulfide substrates from S. aureus, coenzyme A persulfide (CoASSH) and bacillithiol persulfide (BSSH), directly to generate thiosulfate (TS) and reduced thiols, thereby avoiding the cellular toxicity of sulfite.	Sulfites	274-281	cystatin B	Homo sapiens	13-17
25475271-6	2015	Some strains showed high tolerance to sulfite, with genetic analysis indicating linkage of this trait to the transcription factor FZF1, but not to SSU1, the sulfite efflux pump that it regulates in order to confer sulfite tolerance in Saccharomyces cerevisiae.	Sulfites	38-45	Fzf1p	Saccharomyces cerevisiae S288C	130-134
25947166-11	2015	CONCLUSIONS: This study provides new insight into the regulation of sulfur metabolism in wine yeasts and identifies variants of MET2 and SKP2 genes, that control the activity of both branches of the sulfur amino acid synthesis pathway and modulate sulfite/sulfide production and other related phenotypes.	Sulfites	248-255	homoserine O-acetyltransferase	Saccharomyces cerevisiae S288C	128-132
25947166-11	2015	CONCLUSIONS: This study provides new insight into the regulation of sulfur metabolism in wine yeasts and identifies variants of MET2 and SKP2 genes, that control the activity of both branches of the sulfur amino acid synthesis pathway and modulate sulfite/sulfide production and other related phenotypes.	Sulfites	248-255	putative SCF ubiquitin ligase complex subunit SKP2	Saccharomyces cerevisiae S288C	137-141
26171830-1	2015	Mammalian sulfite oxidase (SO) is a dimeric enzyme consisting of a molybdenum cofactor- (Moco) and haem-containing domain and catalyses the oxidation of toxic sulfite to sulfate.	Sulfites	10-17	sulfite oxidase	Homo sapiens	27-29
25777939-1	2015	Sulfite oxidase (SOX) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation and high urinary excretion of sulfite and thiosulfate.	Sulfites	154-161	sulfite oxidase	Rattus norvegicus	0-15
25777939-1	2015	Sulfite oxidase (SOX) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation and high urinary excretion of sulfite and thiosulfate.	Sulfites	154-161	sulfite oxidase	Rattus norvegicus	17-20
25777939-11	2015	However, sulfite inhibited the activities of GPx, GST and G6PDH when cortical slices were exposed for 3h to sulfite.	Sulfites	9-16	hematopoietic prostaglandin D synthase	Rattus norvegicus	50-53
25777939-11	2015	However, sulfite inhibited the activities of GPx, GST and G6PDH when cortical slices were exposed for 3h to sulfite.	Sulfites	9-16	glucose-6-phosphate dehydrogenase	Rattus norvegicus	58-63
25777939-11	2015	However, sulfite inhibited the activities of GPx, GST and G6PDH when cortical slices were exposed for 3h to sulfite.	Sulfites	108-115	hematopoietic prostaglandin D synthase	Rattus norvegicus	50-53
25777939-11	2015	However, sulfite inhibited the activities of GPx, GST and G6PDH when cortical slices were exposed for 3h to sulfite.	Sulfites	108-115	glucose-6-phosphate dehydrogenase	Rattus norvegicus	58-63
25460879-3	2015	hSOx was adsorbed onto this chemically modified nanostructured electrode with high surface loading of electroactive enzyme and in presence of sulphite high anodic bioelectrocatalytic currents were generated with an onset potential of 0.05V vs. NHE.	Sulfites	142-150	solute carrier family 9 member C1	Homo sapiens	244-247
25475271-6	2015	Some strains showed high tolerance to sulfite, with genetic analysis indicating linkage of this trait to the transcription factor FZF1, but not to SSU1, the sulfite efflux pump that it regulates in order to confer sulfite tolerance in Saccharomyces cerevisiae.	Sulfites	157-164	Fzf1p	Saccharomyces cerevisiae S288C	130-134
25291502-2	2015	The probe had exhibited a selective and sensitive response to the sulfite against other thirteen anions and biothiols (Cys, Hcy and GSH), through the nucleophilic addition of sulfite to the alkene of probe with the detection limit of 0.1 muM in HEPES (10 mM, pH 7.4) THF/H2O (1:1, v/v).	Sulfites	66-73	latexin	Homo sapiens	238-241
25372012-7	2014	Likewise, all three models can catalyze the oxidation of sulfite, provided that the Coulombic repulsion between the substrate and the enzyme model can be overcome, but for this harder reaction, the SO model gives the lowest activation barrier, although the differences are not large.	Sulfites	57-64	sulfite oxidase	Homo sapiens	198-200
25486021-3	2015	This study was performed to elucidate the effect of ghrelin on sulfite-induced endoplasmic reticulum (ER) stress and caspase activation in rat peripheral organs.	Sulfites	63-70	ghrelin and obestatin prepropeptide	Rattus norvegicus	52-59
25866561-7	2015	Reverse engineering a prominent mutation in ubiquitin-specific protease gene UBP7 in a laboratory S. cerevisiae strain effectively increased spent sulphite liquor tolerance.	Sulfites	147-155	ubiquitin-specific protease UBP7	Saccharomyces cerevisiae S288C	77-81
24357523-3	2014	The probe exhibited high selectivity and sensitivity towards sulfite over other typical anionic species (F(-), Cl(-), Br(-), I(-), HPO(4)(2-), SO(4)(2-), NO(3)(-), AcO(-), ClO(4)(-), HCO(3)(-)) in HEPES-buffered solution (25 mm, pH 7.4, 50% acetonitrile, v/v).	Sulfites	61-68	kallikrein related peptidase 15	Homo sapiens	164-167
25040038-1	2014	Cysteine dioxygenase (CDO) is involved in regulation of intracellular cysteine levels by catabolising the cysteine to sulphite and sulphate.	Sulfites	118-126	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
25140352-1	2014	Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone.	Sulfites	46-53	microseminoprotein beta	Homo sapiens	26-29
25140352-1	2014	Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone.	Sulfites	46-53	microseminoprotein beta	Homo sapiens	36-39
25140352-4	2014	The detection limits of m-PSP for the analysis of sulfite and sulfide are calculated to 8.5 x 10(-7) M and 2.7 x 10(-7) M, respectively.	Sulfites	50-57	microseminoprotein beta	Homo sapiens	26-29
24957901-1	2014	The oxidation of sulfite to sulfate by two different models of the active site of sulfite oxidase has been studied.	Sulfites	17-24	sulfite oxidase	Homo sapiens	82-97
24793416-1	2014	Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients.	Sulfites	86-93	sulfite oxidase	Homo sapiens	0-15
24857786-2	2014	APR catalyzes the two-electron reduction of APS and forms sulfite and adenosine 5"-monophospahate (AMP).	Sulfites	58-65	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	0-3
24793416-1	2014	Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients.	Sulfites	86-93	sulfite oxidase	Homo sapiens	17-19
24793416-7	2014	Sulfite also induced mitochondrial swelling and reduced mitochondrial membrane potential, Ca(2+) retention capacity, NAD(P)H pool and cytochrome c immunocontent when Ca(2+) was present in the medium.	Sulfites	0-7	cytochrome c, somatic	Homo sapiens	134-146
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Sulfites	20-27	glutathione S-transferase zeta 1	Homo sapiens	43-48
24662917-2	2014	DsrC contains two redox active cysteines in a flexible carboxy-terminal arm that are involved in the process of sulfite reduction or sulfur(1) compound oxidation in sulfur-reducing(2) or sulfur-oxidizing(3) organisms, respectively.	Sulfites	112-119	phosphatidylinositol glycan anchor biosynthesis class P	Homo sapiens	0-4
25195893-1	2014	Plant-type APS reductase (APR), which catalyzes the reduction of activated sulfate to sulfite in plants, consists of a reductase domain and a C-terminal redox domain showing sequence homology to thioredoxin but possessing the activity of glutaredoxin.	Sulfites	86-93	APS reductase 1	Arabidopsis thaliana	11-24
25195893-1	2014	Plant-type APS reductase (APR), which catalyzes the reduction of activated sulfate to sulfite in plants, consists of a reductase domain and a C-terminal redox domain showing sequence homology to thioredoxin but possessing the activity of glutaredoxin.	Sulfites	86-93	APS reductase 1	Arabidopsis thaliana	26-29
25195893-1	2014	Plant-type APS reductase (APR), which catalyzes the reduction of activated sulfate to sulfite in plants, consists of a reductase domain and a C-terminal redox domain showing sequence homology to thioredoxin but possessing the activity of glutaredoxin.	Sulfites	86-93	thioredoxin H-type 1	Arabidopsis thaliana	195-206
25195893-1	2014	Plant-type APS reductase (APR), which catalyzes the reduction of activated sulfate to sulfite in plants, consists of a reductase domain and a C-terminal redox domain showing sequence homology to thioredoxin but possessing the activity of glutaredoxin.	Sulfites	86-93	CAX interacting protein 1	Arabidopsis thaliana	238-250
24841117-6	2014	The most severe of these, an allele of MET10, showed five additional phenotypes: reduced growth rate on sulfate, elevated secretion of sulfite, and reduced production in wine of three volatile sulfur compounds: methionol, carbon disulfide and methylthioacetate.	Sulfites	135-142	sulfite reductase subunit alpha	Saccharomyces cerevisiae S288C	39-44
24987017-1	2014	Sulfite reductase (SiR) is an essential enzyme of the sulfate assimilation reductive pathway, which catalyzes the reduction of sulfite to sulfide.	Sulfites	127-134	sulfite reductase	Solanum lycopersicum	0-17
24987017-1	2014	Sulfite reductase (SiR) is an essential enzyme of the sulfate assimilation reductive pathway, which catalyzes the reduction of sulfite to sulfide.	Sulfites	127-134	sulfite reductase	Solanum lycopersicum	19-22
24987017-5	2014	As a consequence of SiR impairment, the levels of sulfite, sulfate, and thiosulfate were higher and glutathione levels were lower compared with the wild type.	Sulfites	50-57	sulfite reductase	Solanum lycopersicum	20-23
24987017-6	2014	Unexpectedly, in a futile attempt to compensate for the low glutathione, the activity of adenosine-5"-phosphosulfate reductase was enhanced, leading to further sulfite accumulation in SIR Ri plants.	Sulfites	160-167	sulfite reductase	Solanum lycopersicum	184-187
24491762-3	2014	The biosensor responds to sulfite giving a cathodic current (at +200 mV vs screen-printed Ag/AgCl electrode and pH 6) in a wide concentration range, with a capability of detection of 6 muM (alpha=beta=0.05) at 60 C. The method has been applied to the determination of sulfite in white and red samples, with averages recoveries of 101.5% to 101.8%, respectively.	Sulfites	26-33	latexin	Homo sapiens	185-188
24702461-1	2014	Sulfite oxidase is a mitochondria-located molybdenum-containing enzyme catalyzing the oxidation of sulfite to sulfate in the amino acid and lipid metabolism.	Sulfites	99-106	sulfite oxidase	Homo sapiens	0-15
24602570-3	2014	There are now many potent tyrosinase inhibitors, for example, sulfite or kojic acid, but the efficacy of their skin transduction remains a big problem.	Sulfites	62-69	tyrosinase	Homo sapiens	26-36
24491762-3	2014	The biosensor responds to sulfite giving a cathodic current (at +200 mV vs screen-printed Ag/AgCl electrode and pH 6) in a wide concentration range, with a capability of detection of 6 muM (alpha=beta=0.05) at 60 C. The method has been applied to the determination of sulfite in white and red samples, with averages recoveries of 101.5% to 101.8%, respectively.	Sulfites	268-275	latexin	Homo sapiens	185-188
23845496-2	2013	The selective addition of sulfite to the alkene of TSP assisted by cetyltrimethyl ammonium bromide (CTAB) micelle can be visualized by dramatic color and ratiometric fluorescence changes.	Sulfites	26-33	thrombospondin 1	Homo sapiens	51-54
24147957-1	2013	Sulfite oxidase (SO) is an essential molybdoenzyme for humans, catalyzing the final step in the degradation of sulfur-containing amino acids and lipids, which is the oxidation of sulfite to sulfate.	Sulfites	179-186	sulfite oxidase	Homo sapiens	0-15
24073218-4	2013	Like APS reductase, Sat is dispensible for growth on reduced sulfur compounds due to the presence of an alternate, so far unidentified sulfite-oxidizing pathway in A. vinosum.	Sulfites	135-142	streptothricin acetyltransferase	Escherichia coli	20-23
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Sulfites	196-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23973939-4	2013	To examine the response of the p53 signaling pathway to stimulation with different concentrations of sulfite, a time course study of p53, Mdm2, and Bcl-2 expression was conducted in an immortalized hepatic cell line, HL-7702.	Sulfites	101-108	tumor protein p53	Homo sapiens	31-34
23845496-3	2013	In CTAB-PBS system, the fluorescence intensity ratio at 465 nm and 592 nm (I465/I592) and the absorbance ratio at 390 nm and 470 nm (A390/A470) were linearly proportional to sulfite concentration in the range of 0.5-150 muM, and the detection limit was 0.2 muM.	Sulfites	174-181	latexin	Homo sapiens	220-223
23845496-3	2013	In CTAB-PBS system, the fluorescence intensity ratio at 465 nm and 592 nm (I465/I592) and the absorbance ratio at 390 nm and 470 nm (A390/A470) were linearly proportional to sulfite concentration in the range of 0.5-150 muM, and the detection limit was 0.2 muM.	Sulfites	174-181	latexin	Homo sapiens	257-260
23845496-4	2013	Good selectivity and competition of TSP1 towards sulfite over several anions and biological thiols were acquired.	Sulfites	49-56	thrombospondin 1	Homo sapiens	36-40
23845496-5	2013	Probe TSP1 was used to detect sulfite in three realistic samples (mineral water, sugar and white wine) with good recovery.	Sulfites	30-37	thrombospondin 1	Homo sapiens	6-10
23439480-1	2013	This study aimed to investigate the effect of ghrelin administration on sulfite induced oxidative and apoptotic changes in rat gastric mucosa.	Sulfites	72-79	ghrelin and obestatin prepropeptide	Rattus norvegicus	46-53
23779234-1	2013	Sulfite oxidase (SO) is a vital metabolic enzyme that catalyzes the oxidation of toxic sulfite to sulfate.	Sulfites	87-94	sulfite oxidase	Homo sapiens	0-15
23779234-1	2013	Sulfite oxidase (SO) is a vital metabolic enzyme that catalyzes the oxidation of toxic sulfite to sulfate.	Sulfites	87-94	sulfite oxidase	Homo sapiens	17-19
23376232-0	2013	Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils.	Sulfites	0-7	myeloperoxidase	Homo sapiens	30-45
23376232-6	2013	We found that the presence of sulfite can cause MPO-catalyzed oxidation of MPO to a protein radical in phorbol 12-myristate 13-acetate-activated human neutrophils.	Sulfites	30-37	myeloperoxidase	Homo sapiens	48-51
23376232-6	2013	We found that the presence of sulfite can cause MPO-catalyzed oxidation of MPO to a protein radical in phorbol 12-myristate 13-acetate-activated human neutrophils.	Sulfites	30-37	myeloperoxidase	Homo sapiens	75-78
23168241-1	2013	We aimed at investigating the effects of sulfite-induced lipid peroxidation and apoptosis mediated by secretory phospholipase A2 (sPLA2) on somatosensory evoked potentials (SEP) alterations in rats.	Sulfites	41-48	phospholipase A2 group IIA	Rattus norvegicus	102-128
23324180-6	2013	In contrast to the behavior of NBCe1-like activity in renal preparations, we find that cloned NBCe1-A is only slightly stimulated by Li(+), not at all influenced by sulfite or oxalate, and only weakly inhibited by harmaline.	Sulfites	165-172	solute carrier family 4 member 4	Homo sapiens	94-101
23244055-7	2013	The results suggest that sulfite is rapidly autoxidized in the presence of Co(II), Cu(II), Cr(VI), Fe(III), and Mn(II), producing radicals that cause the DNA damage.	Sulfites	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
23244055-8	2013	These radicals can be ranked in a descending order of their ability to induce DNA damage with sulfite as follows: Fe(III) > Co(II) > Cu(II) > Cr(VI) > Mn(II).	Sulfites	94-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
23353986-6	2013	We found that sulfite formation from cysteine relies on the key enzyme cysteine dioxygenase Cdo1.	Sulfites	14-21	cysteine dioxygenase type 1	Homo sapiens	92-96
23392406-3	2013	Sulfite biosensors are based on measurement of either O2 or electrons generated from splitting of H2O2 or heat released during oxidation of sulfite by immobilized sulfite oxidase.	Sulfites	0-7	sulfite oxidase	Homo sapiens	163-178
23392406-3	2013	Sulfite biosensors are based on measurement of either O2 or electrons generated from splitting of H2O2 or heat released during oxidation of sulfite by immobilized sulfite oxidase.	Sulfites	140-147	sulfite oxidase	Homo sapiens	163-178
23168241-1	2013	We aimed at investigating the effects of sulfite-induced lipid peroxidation and apoptosis mediated by secretory phospholipase A2 (sPLA2) on somatosensory evoked potentials (SEP) alterations in rats.	Sulfites	41-48	phospholipase A2 group IIA	Rattus norvegicus	130-135
23168241-9	2013	Immunohistochemistry showed that sulfite caused an increase in caspase-3 and TUNEL positive cells, restored to control levels via quinacrine administration.	Sulfites	33-40	caspase 3	Rattus norvegicus	63-72
23168241-10	2013	This study showed that sPLA2 might play a role in ingested sulfite-induced SEP alterations, oxidative stress, apoptotic cell death and DNA damage in the brain.	Sulfites	59-66	phospholipase A2 group IIA	Rattus norvegicus	23-28
23221833-1	2013	Plant sulfite reductase (SiR; Enzyme Commission 1.8.7.1) catalyzes the reduction of sulfite to sulfide in the reductive sulfate assimilation pathway.	Sulfites	6-13	sulfite reductase	Arabidopsis thaliana	25-28
23221833-9	2013	These results indicate that, in addition to participating in the sulfate assimilation reductive pathway, SiR also plays a role in protecting leaves against the toxicity of sulfite accumulation.	Sulfites	172-179	sulfite reductase	Arabidopsis thaliana	105-108
23148079-7	2013	Hence, under extended dark stress, SO activity is necessary to cope with rising endogenous sulfite levels.	Sulfites	91-98	sulfite oxidase	Solanum lycopersicum	35-37
23440026-1	2013	Sulfite oxidizing enzymes (SOEs), including sulfite oxidase (SO) and bacterial sulfite dehydrogenase (SDH), catalyze the oxidation of sulfite (SO(3) (2-)) to sulfate (SO(4) (2-)).	Sulfites	44-51	sulfite oxidase	Homo sapiens	27-29
23440026-1	2013	Sulfite oxidizing enzymes (SOEs), including sulfite oxidase (SO) and bacterial sulfite dehydrogenase (SDH), catalyze the oxidation of sulfite (SO(3) (2-)) to sulfate (SO(4) (2-)).	Sulfites	44-51	sulfite oxidase	Homo sapiens	61-63
23148079-9	2013	The novel evidence provided by the synchronous dark-induced turnover of sulfur-containing compounds, augmented by exogenous sulfite applications, underlines the role of SO and other sulfite network components in maintaining sulfite homeostasis, where sulfite appears to act as an orchestrating signal molecule.	Sulfites	124-131	sulfite oxidase	Solanum lycopersicum	169-171
23148079-9	2013	The novel evidence provided by the synchronous dark-induced turnover of sulfur-containing compounds, augmented by exogenous sulfite applications, underlines the role of SO and other sulfite network components in maintaining sulfite homeostasis, where sulfite appears to act as an orchestrating signal molecule.	Sulfites	182-189	sulfite oxidase	Solanum lycopersicum	169-171
23025405-1	2012	High concentrations of sulfur dioxide (SO(2) ) as an air pollutant, and its derivative sulfite, cause abiotic stress that can lead to cell death.	Sulfites	87-94	sulfite oxidase	Arabidopsis thaliana	39-41
22709673-12	2012	It is concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA3-2 subdivisions in both normal and SOX deficient rat hippocampus.	Sulfites	49-56	carbonic anhydrase 1	Rattus norvegicus	93-96
22403017-4	2012	Sulphite was shown to inhibit alpha-aminoadipic semialdehyde dehydrogenase in vitro.	Sulfites	0-8	aldehyde dehydrogenase 7 family member A1	Homo sapiens	30-74
22854042-1	2012	Sulfite oxidase (SO) catalyses the metabolic detoxification of sulfite to sulfate within the intermembrane space of mitochondria.	Sulfites	63-70	sulfite oxidase	Homo sapiens	0-15
22854042-1	2012	Sulfite oxidase (SO) catalyses the metabolic detoxification of sulfite to sulfate within the intermembrane space of mitochondria.	Sulfites	63-70	sulfite oxidase	Homo sapiens	17-19
22209453-1	2012	The present study reports a facile approach for sulfite biosensing, based on enhanced direct electron transfer of a human sulfite oxidase (hSO) immobilized on a gold nanoparticles modified electrode.	Sulfites	48-55	sulfite oxidase	Homo sapiens	122-137
22833665-1	2012	Adenosine 5"-phosphosulfate (APS) reductase (APR; EC 1.8.4.9) catalyzes the two-electron reduction of APS to sulfite and AMP, a key step in the sulfate assimilation pathway in higher plants.	Sulfites	109-116	APS reductase 1	Arabidopsis thaliana	45-48
22852582-7	2012	Oxidation of H(2)S by SQOR with sulfite as the sulfane sulfur acceptor is rapid and highly efficient at physiological pH (k(cat)/K(m,H(2)S) = 2.9 x 10(7) M(-1) s(-1)).	Sulfites	32-39	sulfide quinone oxidoreductase	Homo sapiens	22-26
22311478-5	2012	The possible reaction mechanism of sulphite on the [(dpci)2Ir(bvbbi)](PF6)-cerium(IV) system is also briefly discussed.	Sulfites	35-43	sperm associated antigen 17	Homo sapiens	70-73
22709673-11	2012	The results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA3-2) in the S, D and DS groups compared with the control group.	Sulfites	24-31	carbonic anhydrase 1	Rattus norvegicus	155-158
22709673-11	2012	The results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA3-2) in the S, D and DS groups compared with the control group.	Sulfites	24-31	carbonic anhydrase 3	Rattus norvegicus	163-166
22685081-1	2012	Sulfite reductase (SiR; EC 1.8.7.1), an essential enzyme in the sulfate reduction pathway, catalyzes the reduction of sulfite to sulfide, as an intermediate for cysteine biosynthesis.	Sulfites	118-125	sulfite reductase	Arabidopsis thaliana	0-17
22685081-1	2012	Sulfite reductase (SiR; EC 1.8.7.1), an essential enzyme in the sulfate reduction pathway, catalyzes the reduction of sulfite to sulfide, as an intermediate for cysteine biosynthesis.	Sulfites	118-125	sulfite reductase	Arabidopsis thaliana	19-22
22709673-12	2012	It is concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA3-2 subdivisions in both normal and SOX deficient rat hippocampus.	Sulfites	49-56	carbonic anhydrase 3	Rattus norvegicus	101-104
22709673-12	2012	It is concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA3-2 subdivisions in both normal and SOX deficient rat hippocampus.	Sulfites	49-56	quiescin sulfhydryl oxidase 1	Rattus norvegicus	139-142
22326772-3	2012	In this study sulfite (( )SO(3)(-)) and sulfate (SO(4)( -)) anion radicals are characterized with the ESR spin-trapping technique using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) in the reaction of (bi)sulfite oxidation by human MPO and human neutrophils via sulfite radical chain reaction chemistry.	Sulfites	14-21	myeloperoxidase	Homo sapiens	171-174
22224438-6	2012	A salivary component SCN(-) (1 mM) enhanced and suppressed NO production induced by 1 mM nitrite when sulfite concentrations were lower and higher than 1 mM, respectively.	Sulfites	102-109	sorcin	Homo sapiens	21-33
21895698-8	2012	This demonstrates that SO should be the only protagonist for back-oxidizing and detoxification of sulfite.	Sulfites	98-105	sulfite oxidase	Arabidopsis thaliana	23-25
21895698-9	2012	Based on these results, it is suggested that co-regulation of SO and APR controls sulfate assimilation pathway and stabilizes sulfite distribution into organic sulfur compounds.	Sulfites	126-133	sulfite oxidase	Arabidopsis thaliana	62-64
21895698-9	2012	Based on these results, it is suggested that co-regulation of SO and APR controls sulfate assimilation pathway and stabilizes sulfite distribution into organic sulfur compounds.	Sulfites	126-133	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	69-72
21511899-7	2011	Results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA2-CA3) in the sulfite group compared with the control group (p < 0.05, Mann Whitney U test).	Sulfites	175-182	carbonic anhydrase 1	Rattus norvegicus	151-154
22693572-1	2012	Sulfite oxidase (SO) plays an important role in sulfite metabolism.	Sulfites	48-55	sulfite oxidase	Zea mays	0-15
22103391-2	2011	In human asthma, a phenotype with sulfite sensitivity leads to airway inflammation and hyper-responsiveness to inhaled sulfites, and is associated with upregulation of anti-oxidant protein lung carbonyl reductase.	Sulfites	34-41	carbonyl reductase 2	Mus musculus	189-212
21511899-7	2011	Results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA2-CA3) in the sulfite group compared with the control group (p < 0.05, Mann Whitney U test).	Sulfites	20-27	carbonic anhydrase 1	Rattus norvegicus	151-154
21511899-7	2011	Results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA2-CA3) in the sulfite group compared with the control group (p < 0.05, Mann Whitney U test).	Sulfites	20-27	carbonic anhydrase 2	Rattus norvegicus	159-166
21511899-7	2011	Results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA2-CA3) in the sulfite group compared with the control group (p < 0.05, Mann Whitney U test).	Sulfites	175-182	carbonic anhydrase 2	Rattus norvegicus	159-166
21511899-8	2011	It was concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA2-CA3 subdivisions of the rat hippocampus.	Sulfites	50-57	carbonic anhydrase 1	Rattus norvegicus	94-97
21511899-8	2011	It was concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA2-CA3 subdivisions of the rat hippocampus.	Sulfites	50-57	carbonic anhydrase 2	Rattus norvegicus	102-105
21511899-8	2011	It was concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA2-CA3 subdivisions of the rat hippocampus.	Sulfites	50-57	carbonic anhydrase 3	Rattus norvegicus	106-109
21854040-9	2011	The results suggest that whenever S is used as an antibrowning agent, the O-quinone formed with PPO reacts with S to produce sulfo-O-diphenol, which does not participate in browning reactions.	Sulfites	34-35	catechol oxidase B, chloroplastic	Solanum tuberosum	96-99
21854040-9	2011	The results suggest that whenever S is used as an antibrowning agent, the O-quinone formed with PPO reacts with S to produce sulfo-O-diphenol, which does not participate in browning reactions.	Sulfites	112-113	catechol oxidase B, chloroplastic	Solanum tuberosum	96-99
20674338-3	2010	Addition of either Ca(II) or Mg(II) is also effective in counteracting soluble inhibitors of cellulase present in unwashed aspen solid substrate produced by SPORL (sulfite pretreatment to overcome recalcitrance of lignocelluloses).	Sulfites	164-171	carbonic anhydrase 2	Homo sapiens	19-25
21585336-1	2011	APR2 is the dominant APR (adenosine 5"-phosphosulfate reductase) in the model plant Arabidopsis thaliana, and converts activated sulfate to sulfite, a key reaction in the sulfate reduction pathway.	Sulfites	140-147	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	0-4
21585336-1	2011	APR2 is the dominant APR (adenosine 5"-phosphosulfate reductase) in the model plant Arabidopsis thaliana, and converts activated sulfate to sulfite, a key reaction in the sulfate reduction pathway.	Sulfites	140-147	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	0-3
21585336-1	2011	APR2 is the dominant APR (adenosine 5"-phosphosulfate reductase) in the model plant Arabidopsis thaliana, and converts activated sulfate to sulfite, a key reaction in the sulfate reduction pathway.	Sulfites	140-147	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	26-63
20135153-2	2011	The best characterized Str is bovine rhodanese (EC 2.8.1.1) which catalyses in vitro the transfer of a sulfane sulfur atom from thiosulfate to cyanide, leading to the formation of sulfite and thiocyanate.	Sulfites	180-187	thiosulfate sulfurtransferase	Bos taurus	37-46
21305354-4	2011	Low PLP levels were also seen in a group of children with transiently elevated urinary excretion of sulfite and/or sulfocysteine, suggesting that there may be other situations in which sulfite accumulates and inactivates PLP.	Sulfites	185-192	pyridoxal phosphatase	Homo sapiens	4-7
21305354-4	2011	Low PLP levels were also seen in a group of children with transiently elevated urinary excretion of sulfite and/or sulfocysteine, suggesting that there may be other situations in which sulfite accumulates and inactivates PLP.	Sulfites	185-192	pyridoxal phosphatase	Homo sapiens	221-224
21305354-4	2011	Low PLP levels were also seen in a group of children with transiently elevated urinary excretion of sulfite and/or sulfocysteine, suggesting that there may be other situations in which sulfite accumulates and inactivates PLP.	Sulfites	100-107	pyridoxal phosphatase	Homo sapiens	4-7
20698497-1	2010	This paper describes a highly sensitive electrochemical (voltammetric) determination of sulfite using a combination of Starkeya novella sulfite dehydrogenase (SDH), horse heart cytochrome c (cyt c), and a self-assembled monolayer of 11-mercaptoundecanol (MU) cast on a gold electrode.	Sulfites	88-95	cytochrome c, somatic	Equus caballus	177-189
20681972-7	2010	SIGNIFICANCE AND IMPACT OF THE STUDY: The self-cloning brewer"s yeast with high SSU1 expression would contribute to the production of superior quality beer with a high concentration of sulfite and low concentrations of hydrogen sulfide, MBT and 2M3MB.	Sulfites	185-192	Ssu1p	Saccharomyces cerevisiae S288C	80-84
21072368-1	2010	Sulfite oxidase (SO) is a molybdenum-cofactor-dependent enzyme that catalyzes the oxidation of sulfite to sulfate, the final step in the catabolism of the sulfur-containing amino acids, cysteine and methionine.	Sulfites	95-102	sulfite oxidase	Homo sapiens	0-15
21072368-1	2010	Sulfite oxidase (SO) is a molybdenum-cofactor-dependent enzyme that catalyzes the oxidation of sulfite to sulfate, the final step in the catabolism of the sulfur-containing amino acids, cysteine and methionine.	Sulfites	95-102	sulfite oxidase	Homo sapiens	17-19
20698497-1	2010	This paper describes a highly sensitive electrochemical (voltammetric) determination of sulfite using a combination of Starkeya novella sulfite dehydrogenase (SDH), horse heart cytochrome c (cyt c), and a self-assembled monolayer of 11-mercaptoundecanol (MU) cast on a gold electrode.	Sulfites	88-95	cytochrome c, somatic	Equus caballus	191-196
20571963-11	2010	When SOX-deficient rats treated with sulfite, TBARS level was still higher than other groups.	Sulfites	37-44	sulfite oxidase	Rattus norvegicus	5-8
20666399-3	2010	In animals, SO catalyzes the oxidation of toxic sulfite to sulfate as the final step in the catabolism of the sulfur-containing amino acids, methionine and cysteine.	Sulfites	48-55	sulfite oxidase	Homo sapiens	12-14
20571963-3	2010	Sulfite is a very reactive and potentially toxic molecule and has to be detoxified by the enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	97-112
20571963-3	2010	Sulfite is a very reactive and potentially toxic molecule and has to be detoxified by the enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	114-117
19140755-1	2009	We present a density functional theory (DFT) study on the conversion of sulfite to sulfate with a model complex representing the active site of the molybdenum-containing enzyme sulfite oxidase (SO).	Sulfites	72-79	sulfite oxidase	Homo sapiens	177-192
19793632-1	2010	Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids.	Sulfites	107-114	sulfite oxidase	Homo sapiens	0-15
19793632-1	2010	Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids.	Sulfites	107-114	sulfite oxidase	Homo sapiens	57-61
20501663-0	2010	Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite.	Sulfites	86-93	eosinophil peroxidase	Homo sapiens	41-62
20356030-1	2010	Sulfite oxidase (SO) catalyzes the physiologically critical conversion of sulfite to sulfate.	Sulfites	74-81	sulfite oxidase	Gallus gallus	0-15
20356030-1	2010	Sulfite oxidase (SO) catalyzes the physiologically critical conversion of sulfite to sulfate.	Sulfites	74-81	sulfite oxidase	Gallus gallus	17-19
20063894-1	2010	Sulfite oxidase (SO) is a vitally important molybdenum enzyme that catalyzes the oxidation of toxic sulfite to sulfate.	Sulfites	100-107	sulfite oxidase	Homo sapiens	0-15
20063894-1	2010	Sulfite oxidase (SO) is a vitally important molybdenum enzyme that catalyzes the oxidation of toxic sulfite to sulfate.	Sulfites	100-107	sulfite oxidase	Homo sapiens	17-19
20358871-1	2010	Sulfite oxidase [SO; EC 1.8.3.1] catalyses the physiologically vital oxidation of sulfite to sulfate, the terminal reaction in degradation of sulfur containing amino acids, cysteine and methionine.	Sulfites	82-89	sulfite oxidase	Arabidopsis thaliana	0-15
20358871-1	2010	Sulfite oxidase [SO; EC 1.8.3.1] catalyses the physiologically vital oxidation of sulfite to sulfate, the terminal reaction in degradation of sulfur containing amino acids, cysteine and methionine.	Sulfites	82-89	sulfite oxidase	Arabidopsis thaliana	17-19
18553142-4	2009	For this purpose, rats were divided into four groups: control, sulfite-treated, SOX-deficient, and sulfite-treated SOX-deficient groups.	Sulfites	99-106	sulfite oxidase	Rattus norvegicus	115-118
18553142-10	2009	In conclusion, sulfite treatment affects the antioxidant/oxidant balance of the plasma cells of the rats toward oxidants in SOX-deficient groups.	Sulfites	15-22	sulfite oxidase	Rattus norvegicus	124-127
19373630-6	2009	To date, there have not been any reports on the effect of asthma drugs on the suppression of IL-8 production induced by sulfite in A549 cells or the involvement of specific signal transduction pathways.	Sulfites	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19175577-10	2009	Only IL-6 was significantly higher in the LPS Propofol(sulfite) group compared with both the Ket/Mid group and the Propofol(EDTA) group.	Sulfites	55-62	interleukin 6	Homo sapiens	5-9
20509690-8	2010	Significant improvement in SED of about over 27% of a eucalyptus substrate produced by sulfite pretreatment to overcome recalcitrance of lignocellulose (SPORL) was achieved with the application of Ca(II).	Sulfites	87-94	carbonic anhydrase 2	Homo sapiens	197-203
20203053-0	2010	A sulphite-inducible form of the sulphite efflux gene SSU1 in a Saccharomyces cerevisiae wine yeast.	Sulfites	2-10	Ssu1p	Saccharomyces cerevisiae S288C	54-58
20203053-0	2010	A sulphite-inducible form of the sulphite efflux gene SSU1 in a Saccharomyces cerevisiae wine yeast.	Sulfites	33-41	Ssu1p	Saccharomyces cerevisiae S288C	54-58
20203053-3	2010	Sulphite detoxification, involving a plasma membrane protein encoded by the SSU1 gene, is the most efficient resistance mechanism in S. cerevisiae.	Sulfites	0-8	Ssu1p	Saccharomyces cerevisiae S288C	76-80
20203053-5	2010	We provide, for the first time, evidence of SSU1 induction by sulphite.	Sulfites	62-70	Ssu1p	Saccharomyces cerevisiae S288C	44-48
20203053-6	2010	The study of SSU1 expression during fermentation and in different growth conditions showed that sulphite is the main regulator of SSU1 expression, explaining its specific pattern.	Sulfites	96-104	Ssu1p	Saccharomyces cerevisiae S288C	13-17
20203053-6	2010	The study of SSU1 expression during fermentation and in different growth conditions showed that sulphite is the main regulator of SSU1 expression, explaining its specific pattern.	Sulfites	96-104	Ssu1p	Saccharomyces cerevisiae S288C	130-134
20203053-7	2010	Combining analyses of gene expression and growth behaviour in response to sulphite, we found that 71B displayed unique behavioural patterns in response to sulphite pre-adaptation that may be explained by changes in SSU1 expression.	Sulfites	155-163	Ssu1p	Saccharomyces cerevisiae S288C	215-219
19923196-2	2010	The key step in the pathway is the reduction of activated sulphate, adenosine 5"-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR).	Sulfites	107-115	APS reductase 1	Arabidopsis thaliana	129-142
19923196-2	2010	The key step in the pathway is the reduction of activated sulphate, adenosine 5"-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR).	Sulfites	107-115	APS reductase 1	Arabidopsis thaliana	144-147
19923196-10	2010	(ii) No effect on sulphur flux was observed when the sulphite oxidase (SO) gene from Arabidopsis thaliana, which catalyses the back reaction of APR, that is the reaction from sulphite to sulphate, was overexpressed.	Sulfites	53-61	APS reductase 1	Arabidopsis thaliana	144-147
18553142-2	2009	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfite to sulfate protecting cells from sulfite toxicity.	Sulfites	92-99	sulfite oxidase	Rattus norvegicus	0-15
18553142-2	2009	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfite to sulfate protecting cells from sulfite toxicity.	Sulfites	92-99	sulfite oxidase	Rattus norvegicus	17-20
18553142-2	2009	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfite to sulfate protecting cells from sulfite toxicity.	Sulfites	133-140	sulfite oxidase	Rattus norvegicus	0-15
18553142-2	2009	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfite to sulfate protecting cells from sulfite toxicity.	Sulfites	133-140	sulfite oxidase	Rattus norvegicus	17-20
19140755-1	2009	We present a density functional theory (DFT) study on the conversion of sulfite to sulfate with a model complex representing the active site of the molybdenum-containing enzyme sulfite oxidase (SO).	Sulfites	72-79	sulfite oxidase	Homo sapiens	194-196
19093831-13	2009	These comparative TGA/mass studies help to understand how the organic free linker elevates the thermal stability of the sulfite encapsulated POV cluster anion in going from a discrete cluster anion to the linked system (molecule to material).	Sulfites	120-127	T-box transcription factor 1	Homo sapiens	18-21
18932024-0	2009	Electrocatalytic sulfite biosensor with human sulfite oxidase co-immobilized with cytochrome c in a polyelectrolyte-containing multilayer.	Sulfites	17-24	cytochrome c, somatic	Homo sapiens	82-94
19239123-1	2008	Sulfite oxidase (EC 1.8.3.1) catalyzes the physiologically vital oxidation of sulfite to sulfate, the terminal reaction in the degradation of sulfur containing amino acids.	Sulfites	78-85	sulfite oxidase, mitochondrial	Capra hircus	0-15
18974956-7	2008	Cells treated with sulfite generated more than 70% of acetaldehyde than untreated cells, suggesting that the increased acetaldehyde production is correlated with the induction of PDC1 gene encoding pyruvate decarboxylase.	Sulfites	19-26	indolepyruvate decarboxylase 1	Saccharomyces cerevisiae S288C	179-183
19271535-0	2008	[Effect of SSU1 multi-copy expression on Saccharomyces cerevisiae sulphite production].	Sulfites	66-74	Ssu1p	Saccharomyces cerevisiae S288C	11-15
19271535-2	2008	In Saccharomyces cerevisiae, excretion of sulfite is regulated by sulfite transporter protein Ssulp which is encoded by SSU1.	Sulfites	42-49	Ssu1p	Saccharomyces cerevisiae S288C	120-124
19271535-10	2008	CONCLUSION: Over-expression of SSU1 in both laboratory S. cerevisiae strain and industrial brewing yeast strain increased their sulphite excretion, enhanced beer antioxidant abilities and had no negative effect on sulfur-containing amino acids biosynthesis.	Sulfites	128-136	Ssu1p	Saccharomyces cerevisiae S288C	31-35
18804647-5	2008	The peak potential for the oxidation of sulfite was lowered by at least 330 mV compared with that obtained at CHIT/MWCNTs/GCE.	Sulfites	40-47	chitinase 1	Homo sapiens	110-114
18854902-2	2008	These studies indicated that only Co(II) complexed with glycylglycylhistidine (GGH) induced DNA strand breaks at low sulfite concentrations (1-80 microM) via strong oxidants formed in the reaction.	Sulfites	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
18854902-3	2008	In the presence of the other complexes, some damage occurred only in the presence of high sulfite concentrations (0.1-2.0 mM) after incubation for 4 h. In the presence of GGH, Co(II) and dissolved O2, DNA damage must involve a reactive high-valent cobalt complex.	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
27879796-0	2008	Amperometric Determination of Sulfite by Gas Diffusion- Sequential Injection with Boron-Doped Diamond Electrode.	Sulfites	30-37	gastrin	Homo sapiens	41-44
18286237-1	2008	A noticeable effect of sulfite treatment was observed on the plasma ceruloplasmin ferroxidase activity of rats with normal sulfite oxidase activity when compared to normal controls.	Sulfites	23-30	ceruloplasmin	Rattus norvegicus	68-81
18286237-1	2008	A noticeable effect of sulfite treatment was observed on the plasma ceruloplasmin ferroxidase activity of rats with normal sulfite oxidase activity when compared to normal controls.	Sulfites	23-30	sulfite oxidase	Rattus norvegicus	123-138
18286237-4	2008	Treating SOX-deficient groups with sulfite did not alter plasma level of Mn but made plasma level of Cu back to its normal level.	Sulfites	35-42	sulfite oxidase	Rattus norvegicus	9-12
18842692-2	2008	Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC.	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	38-53
18842692-2	2008	Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC.	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	55-58
18579106-4	2008	In the present study, sulfite toxicity towards isolated rat hepatocytes was markedly increased by partial inhibition of cytochrome a/a(3) by cyanide or by putting rats on a high-tungsten/low-molybdenum diet, which result in inactivation of sulfite oxidase.	Sulfites	22-29	sulfite oxidase	Rattus norvegicus	240-255
17613108-0	2007	Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats.	Sulfites	19-26	sulfite oxidase	Rattus norvegicus	75-90
18034293-0	2008	Sulfite increases lipoperoxidation and decreases the activity of catalase in brain of rats.	Sulfites	0-7	catalase	Rattus norvegicus	65-73
18034293-1	2008	The main objective of this study was to investigate the in vitro effects of sulfite, a metabolite accumulated in isolated sulfite oxidase deficiency, on Na (+), K (+)-ATPase activity and on some parameters of oxidative stress, namely thiobarbituric acid-reactive substances (TBARS) and catalase activity (antioxidant enzyme) in cerebral cortex, striatum and hippocampus from 10- and 60-day-old rats.	Sulfites	76-83	catalase	Rattus norvegicus	286-294
18034293-2	2008	Results showed that 500 microM sulfite significantly increased TBARS and reduced catalase activity in the cerebral structures studied from neonates and adults rats; in contrast, sulfite did not alter Na(+), K(+)-ATPase activity.	Sulfites	31-38	catalase	Rattus norvegicus	81-89
17853359-7	2007	Hence we assume that SO could possibly serve as "safety valve" for detoxifying excess amounts of sulfite and protecting the cell from sulfitolysis.	Sulfites	97-104	sulfite oxidase	Arabidopsis thaliana	21-23
17983221-1	2007	Sulfite oxidase from Arabidopsis thaliana has been reduced at pH = 6 with sulfite labeled with 33S (nuclear spin I = 3/2), followed by reoxidation by ferricyanide to generate the Mo(V) state of the active center.	Sulfites	74-81	sulfite oxidase	Arabidopsis thaliana	0-15
17967036-5	2007	Here, we describe the formation of anionic 5,6-dihydro-6-sulfonyl derivatives by spontaneous addition of sulfite to UMP and to OMP.	Sulfites	105-112	olfactory marker protein	Homo sapiens	127-130
17613108-2	2007	Sulfite, which is a very reactive and potentially toxic molecule, is detoxified by the enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	94-109
17613108-2	2007	Sulfite, which is a very reactive and potentially toxic molecule, is detoxified by the enzyme sulfite oxidase (SOX).	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	111-114
17613108-4	2007	It has been suggested that SOX deficient rats might be used as a model for the prediction of sulfite toxicity in humans.	Sulfites	93-100	sulfite oxidase	Rattus norvegicus	27-30
17459792-9	2007	IET studies on animal SO and bacterial SDH clearly demonstrate the similarities and differences between these two types of sulfite oxidizing enzymes.	Sulfites	123-130	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	39-42
17320039-5	2007	In hypotonic medium, magnesium and potassium ions have a protective effect on the release of enzymes and on the reactivity of cyto-c as electron acceptor from both sulfite and succinate; results which are consistent with the view that MOM preserves its identity and remains not permeable to exogenous cyto-c.	Sulfites	164-171	cytochrome c, somatic	Homo sapiens	126-132
16979290-5	2007	Strain SA2 used thiosulfate, sulfate, sulfite and elemental sulfur as electron acceptors and produced sulfide.	Sulfites	38-45	stromal antigen 2	Homo sapiens	7-10
17425719-1	2007	The gaseous pollutant SO(2) readily reacts with water to form sulfite that impacts deleteriously on animal and plant health.	Sulfites	62-69	sulfite oxidase	Arabidopsis thaliana	22-24
19071674-0	2007	Comparative electrooxidation of sulphite by self-assembled monolayers (SAMs) of Co(II), Fe(II), Ni(II) and Mn(III) tetrakis benzylmercapto and dodecylmercapto metallophthalocyanines complexes on gold electrodes.	Sulfites	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19071674-1	2007	This work reports on the use of Co(II), Fe(II), Mn(III) and Ni(II) tetrakis benzylmercapto and dodecylmercapto phthalocyanine complexes for gold electrode modification for electrooxidation of sulphite ions.	Sulfites	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
17371503-1	2007	Sulfite reductase (SiR) is an important enzyme catalyzing the reduction of sulfite to sulfide during sulfur assimilation in plants.	Sulfites	75-82	sulfite reductase [ferredoxin], chloroplastic	Zea mays	0-17
17371503-1	2007	Sulfite reductase (SiR) is an important enzyme catalyzing the reduction of sulfite to sulfide during sulfur assimilation in plants.	Sulfites	75-82	sulfite reductase [ferredoxin], chloroplastic	Zea mays	19-22
16924954-8	2006	Spectrophotometric measurement of copper/zinc superoxide dismutase (Cu/Zn SOD) and catalase (CAT) revealed decreased enzyme activities in rats exposed to restraint stress compared to control and sulfite-treated rats.	Sulfites	195-202	superoxide dismutase 1	Rattus norvegicus	68-77
16934831-4	2006	Enzyme containing>or=90% unmodified FMN is prepared by displacement of the endogenous ligand with sulfite, a less tightly bound competing ligand.	Sulfites	101-108	formin 1	Homo sapiens	39-42
16881685-6	2006	The concentration of methionine, adenine, and sulfite in a synthetic grape must influences the progress of fermentation and at the transcriptional level the expression of genes involved in sulfur (MET16), adenine (ADE4), and acetaldehyde (ALD6) metabolism.	Sulfites	46-53	phosphoadenylyl-sulfate reductase (thioredoxin)	Saccharomyces cerevisiae S288C	197-202
16881685-6	2006	The concentration of methionine, adenine, and sulfite in a synthetic grape must influences the progress of fermentation and at the transcriptional level the expression of genes involved in sulfur (MET16), adenine (ADE4), and acetaldehyde (ALD6) metabolism.	Sulfites	46-53	amidophosphoribosyltransferase	Saccharomyces cerevisiae S288C	214-218
16881685-6	2006	The concentration of methionine, adenine, and sulfite in a synthetic grape must influences the progress of fermentation and at the transcriptional level the expression of genes involved in sulfur (MET16), adenine (ADE4), and acetaldehyde (ALD6) metabolism.	Sulfites	46-53	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	239-243
17175208-7	2007	The structure of TTR pre-incubated with sulfite at physiological pH, was determined by X-ray crystallography to provide structural insight for the stabilizing effect of sulfite.	Sulfites	40-47	transthyretin	Homo sapiens	17-20
17175208-7	2007	The structure of TTR pre-incubated with sulfite at physiological pH, was determined by X-ray crystallography to provide structural insight for the stabilizing effect of sulfite.	Sulfites	169-176	transthyretin	Homo sapiens	17-20
17000536-7	2006	It was concluded that exogenous administration of sulfite affected the brain electrical activity in SOX deficiency, and improved neuroprotection.	Sulfites	50-57	sulfite oxidase	Rattus norvegicus	100-103
16858610-0	2006	Expressions of N-methyl-D-aspartate receptors NR2A and NR2B subunit proteins in normal and sulfite-oxidase deficient rat"s hippocampus: effect of exogenous sulfite ingestion.	Sulfites	91-98	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	46-50
16858610-0	2006	Expressions of N-methyl-D-aspartate receptors NR2A and NR2B subunit proteins in normal and sulfite-oxidase deficient rat"s hippocampus: effect of exogenous sulfite ingestion.	Sulfites	91-98	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	55-59
16858610-2	2006	Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate.	Sulfites	128-135	sulfite oxidase	Homo sapiens	0-15
16858610-2	2006	Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate.	Sulfites	128-135	sulfite oxidase	Homo sapiens	17-20
16858610-2	2006	Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate.	Sulfites	161-168	sulfite oxidase	Homo sapiens	0-15
16858610-2	2006	Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate.	Sulfites	161-168	sulfite oxidase	Homo sapiens	17-20
16858610-3	2006	The present study was aimed to investigate effect of sulfite on the N-methyl-D-aspartate (NMDA) receptor (NMDAR) NR2A and NR2B subunits in hippocampus of normal and SOX-deficient rats.	Sulfites	53-60	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	113-117
16858610-3	2006	The present study was aimed to investigate effect of sulfite on the N-methyl-D-aspartate (NMDA) receptor (NMDAR) NR2A and NR2B subunits in hippocampus of normal and SOX-deficient rats.	Sulfites	53-60	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	122-126
16858610-6	2006	Sulfite treatment caused a decrease of NR2A and NR2B subunits of the NMDAR in hippocampus of rats in S and DS groups.	Sulfites	0-7	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	39-43
16858610-6	2006	Sulfite treatment caused a decrease of NR2A and NR2B subunits of the NMDAR in hippocampus of rats in S and DS groups.	Sulfites	0-7	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	48-52
16924954-8	2006	Spectrophotometric measurement of copper/zinc superoxide dismutase (Cu/Zn SOD) and catalase (CAT) revealed decreased enzyme activities in rats exposed to restraint stress compared to control and sulfite-treated rats.	Sulfites	195-202	catalase	Rattus norvegicus	83-91
16924954-8	2006	Spectrophotometric measurement of copper/zinc superoxide dismutase (Cu/Zn SOD) and catalase (CAT) revealed decreased enzyme activities in rats exposed to restraint stress compared to control and sulfite-treated rats.	Sulfites	195-202	catalase	Rattus norvegicus	93-96
17723349-0	2006	Determination of sulfite in beer samples using an amperometric fill and flow channel biosensor employing sulfite oxidase.	Sulfites	17-24	sulfite oxidase	Homo sapiens	105-120
16407262-7	2006	In the plant, sulfite oxidase could be responsible for removing sulfite as a toxic metabolite, which might represent a means to protect the cell against excess of sulfite derived from SO2 gas in the atmosphere (acid rain) or during the decomposition of sulfur-containing amino acids.	Sulfites	64-71	sulfite oxidase	Arabidopsis thaliana	14-29
16719114-6	2006	Sulfite, sulfide, and elevated chloride decreased the NO3- reduction rate by over 2 orders of magnitude.	Sulfites	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
16150638-0	2006	Inhibition of superoxide dismutase, Vitamin C and glutathione on chemiluminescence produced by luminol and the mixture of sulfite and bisulfite.	Sulfites	122-129	superoxide dismutase 1	Homo sapiens	14-34
17723349-8	2006	The enzyme layer contains sulfite oxidase, which, in the process of oxidizing sulfite, produces hydrogen peroxide, which itself is reduced by excess sulfite.	Sulfites	78-85	sulfite oxidase	Homo sapiens	26-41
16579462-5	2006	One of them, APS kinase (encoded by MET14) plays important role in the process of sulphite formation.	Sulfites	82-90	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	36-41
16579462-6	2006	In order to construct high sulphite-producing brewing yeast strain for beer production, MET14 gene was cloned and overexpressed in industrial strain of Saccharomyces cerevisiae.	Sulfites	27-35	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	88-93
16579462-15	2006	The sulphite production of the transformants carrying pPM was 2 fold of that in the control strain YS58, which showed that the MET14 gene on plasmid pPM was expressed functionally in YS58.	Sulfites	4-12	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	127-132
16579462-21	2006	The overexpression of MET14 gene in both laboratory and industrial strains of S. cerevisiae increases the sulphite formation.	Sulfites	106-114	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	22-27
16150492-1	2006	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfur amino acids, and protects cells from sulfite (SO(3)(2-)) toxicity.	Sulfites	136-143	sulfite oxidase	Rattus norvegicus	0-15
16579462-22	2006	It is the first time to construct high sulphite-producing industrial strain by functional expression of MET14 in S. cerevisiae.	Sulfites	39-47	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	104-109
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	29-36	cytochrome c, somatic	Homo sapiens	37-49
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	29-36	cytochrome c, somatic	Homo sapiens	124-136
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	29-36	cytochrome c, somatic	Homo sapiens	124-136
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	87-94	cytochrome c, somatic	Homo sapiens	37-49
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	87-94	cytochrome c, somatic	Homo sapiens	124-136
17009250-5	2006	After copper is added to the sulfite-cytochrome c binary systems, the reaction between sulfite and the protein component in cytochrome c is obviously strengthened at a low concentration (K(A) = 7.289 L mol(-1)), while the addition of copper merely has a little effect on the interaction between sulfite and the ferroporphyrin component in cytochrome c.	Sulfites	87-94	cytochrome c, somatic	Homo sapiens	124-136
16150492-1	2006	Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfur amino acids, and protects cells from sulfite (SO(3)(2-)) toxicity.	Sulfites	136-143	sulfite oxidase	Rattus norvegicus	17-20
16150492-17	2006	Furthermore, sulfite exposure resulted in greater lipid peroxidation and more electrophysiological alterations in the SOX deficient rats than in the control rats.	Sulfites	13-20	sulfite oxidase	Rattus norvegicus	118-121
15681120-2	2005	Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC.	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	38-53
16269753-5	2005	Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature.	Sulfites	376-383	transcription elongation factor A1	Homo sapiens	50-54
16008502-2	2005	In this reaction, activated sulfate in the context of adenosine-5"-phosphosulfate (APS) or 3"-phosphoadenosine 5"-phosphosulfate (PAPS) is converted to sulfite with reducing equivalents from thioredoxin.	Sulfites	152-159	thioredoxin	Homo sapiens	191-202
16008502-7	2005	Sulfite is then released in a thioredoxin-dependent manner.	Sulfites	0-7	thioredoxin	Homo sapiens	30-41
16289095-7	2005	The LDL-oxidase activity of ceruloplasmin was also stimulated by sulfite.	Sulfites	65-72	ceruloplasmin	Homo sapiens	28-41
16234925-1	2005	The physiologically essential oxidation of sulfite to sulfate is catalyzed by the molybdoheme enzyme, sulfite oxidase.	Sulfites	43-50	sulfite oxidase	Homo sapiens	102-117
16099456-2	2005	Disruption of flr gene strongly inhibited the reduction of thiosulfate and exhibited a reduced growth in the presence of sulfite with lactate as electron donor.	Sulfites	121-128	biliverdin reductase B	Homo sapiens	14-17
21162184-10	2005	Its mechanism may involve oxidation damage in the rat hippocampal CA1 neurons, caused by sulfur- and oxygen-centered free radicals formed in the process of sulfite or bisulfite oxidation.	Sulfites	156-163	carbonic anhydrase 1	Rattus norvegicus	66-69
15681120-2	2005	Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC.	Sulfites	0-7	sulfite oxidase	Rattus norvegicus	55-58
15681120-8	2005	In SOX-deficient rats, TBARS levels were found to be significantly increased with sulfite exposure.	Sulfites	82-89	sulfite oxidase	Rattus norvegicus	3-6
15681120-9	2005	Vitamin E reversed the observed detrimental effects of sulfite in the SOX-deficient rats on their hippocampal TBARS but not on their active avoidance learning.	Sulfites	55-62	sulfite oxidase	Rattus norvegicus	70-73
14534839-0	2004	Sulfite and base for the treatment of familial amyloidotic polyneuropathy: two additive approaches to stabilize the conformation of human amyloidogenic transthyretin.	Sulfites	0-7	transthyretin	Homo sapiens	152-165
14729666-3	2004	In steady-state assays of Y343F sulfite oxidase using cytochrome c as the electron acceptor, k(cat) was somewhat impaired ( approximately 34% wild-type activity at pH 8.5), whereas the K(m)(sulfite) showed a 5-fold increase over wild type.	Sulfites	32-39	cytochrome c, somatic	Homo sapiens	54-66
14729666-9	2004	These results demonstrate that the Tyr(343) residue is important for both substrate binding and oxidation of sulfite by sulfite oxidase.	Sulfites	109-116	sulfite oxidase	Homo sapiens	120-135
15574895-4	2004	Even though the selection for sulfite resistance conferred by FZF1-4 resulted in a larger number of transformants for a laboratory strain, the p-fluoro-DL-phenylalanine resistance conferred by ARO4-OFP resulted in a more suitable selection marker for all industrial strains tested.	Sulfites	30-37	Fzf1p	Saccharomyces cerevisiae S288C	62-66
15273247-5	2004	Glutamate dehydrogenase (GDH) in rat brain mitochondrial extract was inhibited dose-dependently by sulfite as was the activity of a purified enzyme.	Sulfites	99-106	glutamate dehydrogenase 1	Homo sapiens	25-28
15273247-8	2004	We propose that GDH is one target of action of sulfite, leading to a decrease in alpha-ketoglutarate and a diminished flux through the tricarboxylic acid cycle accompanied by a decrease in NADH through the mitochondrial electron transport chain, a decreased MMP, and a decrease in ATP synthesis.	Sulfites	47-54	glutamate dehydrogenase 1	Homo sapiens	16-19
15273247-9	2004	Because glutamate is a major metabolite in the brain, inhibition of GDH by sulfite could contribute to the severe phenotype of sulfite oxidase deficiency in human infants.	Sulfites	75-82	glutamate dehydrogenase 1	Homo sapiens	68-71
14534839-1	2004	Recently, we presented evidence that sulfite protects transthyretin (TTR) from normal human individuals and heterozygotes with amyloidogenic TTR mutations against the decay of tetramers into monomers.	Sulfites	37-44	transthyretin	Homo sapiens	54-67
14534839-1	2004	Recently, we presented evidence that sulfite protects transthyretin (TTR) from normal human individuals and heterozygotes with amyloidogenic TTR mutations against the decay of tetramers into monomers.	Sulfites	37-44	transthyretin	Homo sapiens	69-72
14534839-1	2004	Recently, we presented evidence that sulfite protects transthyretin (TTR) from normal human individuals and heterozygotes with amyloidogenic TTR mutations against the decay of tetramers into monomers.	Sulfites	37-44	transthyretin	Homo sapiens	141-144
14534839-2	2004	In this paper we demonstrate a stabilizing effect of sulfite on TTR tetramers from a familial amyloidotic polyneuropathy (FAP) patient homozygous for the most-common amyloidogenic TTR-V30 M mutation.	Sulfites	53-60	transthyretin	Homo sapiens	64-67
14534839-2	2004	In this paper we demonstrate a stabilizing effect of sulfite on TTR tetramers from a familial amyloidotic polyneuropathy (FAP) patient homozygous for the most-common amyloidogenic TTR-V30 M mutation.	Sulfites	53-60	transthyretin	Homo sapiens	180-183
14514920-2	2003	Sulfate for conjugation is produced primarily from the oxidation of cysteine, begun by cysteine dioxygenase (CDO), and completed with the conversion of sulfite to sulfate via sulfite oxidase (SO).	Sulfites	152-159	sulfite oxidase	Homo sapiens	175-190
15356722-2	2004	The oxidation of Ni(II) and Co(II) tetraglycine complexes in borate buffer aqueous solution, by dissolved oxygen, is strongly accelerated by sulfite.	Sulfites	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
14717192-1	2003	Experimental data from a laboratory-scale wet scrubber simulator confirmed that oxidized mercury, Hg2+, can be reduced by aqueous S(IV) (sulfite and/or bisulfite) species and results in elemental mercury (HgO) emissions under typical wet FGD scrubber conditions.	Sulfites	137-144	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	98-101
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	111-118	sulfite oxidase	Homo sapiens	57-59
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	111-118	sulfite oxidase	Homo sapiens	178-180
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	111-118	Rho GTPase activating protein 26	Homo sapiens	301-305
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	231-238	sulfite oxidase	Homo sapiens	57-59
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	231-238	sulfite oxidase	Homo sapiens	178-180
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Sulfites	231-238	Rho GTPase activating protein 26	Homo sapiens	301-305
14567685-7	2003	In the crystal structure of chicken SO, Arg 138, the equivalent of Arg 160 in human SO, is involved in the formation of a positively charged sulfite binding site [Kisker, C., Schindelin, H., Pacheco, A., Wehbi, W., Garnett, R. M., Rajagopalan, K. V., Enemark, J. H., Rees, D. C. (1997) Cell 91, 973-983].	Sulfites	141-148	sulfite oxidase	Homo sapiens	36-38
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-143
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-155
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-143
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-155
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
14580323-5	2003	Sulfite-mediated disulfide bond cleavage followed by reaction with 2-nitro-5-thiosulfobenzoate showed that oxidized p53 contains a single disulfide bond per monomer.	Sulfites	0-7	tumor protein p53	Homo sapiens	116-119
14514920-2	2003	Sulfate for conjugation is produced primarily from the oxidation of cysteine, begun by cysteine dioxygenase (CDO), and completed with the conversion of sulfite to sulfate via sulfite oxidase (SO).	Sulfites	152-159	sulfite oxidase	Homo sapiens	192-194
12147719-2	2002	(1) Nitrate reductase catalyses the key step in inorganic nitrogen assimilation, (2) aldehyde oxidase(s) have been shown to catalyse the last step in the biosynthesis of the phytohormone abscisic acid, (3) xanthine dehydrogenase is involved in purine catabolism and stress reactions, and (4) sulphite oxidase is probably involved in detoxifying excess sulphite.	Sulfites	292-300	aldehyde oxidase 1	Homo sapiens	85-101
14674462-3	2003	The efficiency of the bioelectrocatalytic 2e- oxidation of sulfite catalyzed by SOx in direct ET exchange with the electrode was shown to depend essentially on the nature of the alkanethiol layer.	Sulfites	59-66	sulfite oxidase	Gallus gallus	80-83
14674462-4	2003	Adsorption and orientation of SOx on an 11-mercapto-1-undecanol (MuD-OH) self-assembled monolayer, i.e., terminally functionalized with OH groups, provided efficient catalytic oxidation of sulfite, contrary to nonfunctionalized alkanethiols, e.g., 1-decanethiol, or alkanethiol layers terminally functionalized with NH2 groups.	Sulfites	189-196	sulfite oxidase	Gallus gallus	30-33
12147719-2	2002	(1) Nitrate reductase catalyses the key step in inorganic nitrogen assimilation, (2) aldehyde oxidase(s) have been shown to catalyse the last step in the biosynthesis of the phytohormone abscisic acid, (3) xanthine dehydrogenase is involved in purine catabolism and stress reactions, and (4) sulphite oxidase is probably involved in detoxifying excess sulphite.	Sulfites	292-300	xanthine dehydrogenase	Homo sapiens	206-228
11557133-3	2001	Two pathways of sulfite oxidation are known: (1) direct oxidation to sulfate catalyzed by a sulfite:acceptor oxidoreductase, which is thought to be a molybdenum-containing enzyme; (2) indirect oxidation under the involvement of the enzymes adenylylsulfate (APS) reductase and ATP sulfurylase and/or adenylylsulfate:phosphate adenylyltransferase with APS as an intermediate.	Sulfites	16-23	thioredoxin reductase 1	Homo sapiens	109-123
11921096-0	2002	Increasing sulphite formation in Saccharomyces cerevisiae by overexpression of MET14 and SSU1.	Sulfites	11-19	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	79-84
11921096-0	2002	Increasing sulphite formation in Saccharomyces cerevisiae by overexpression of MET14 and SSU1.	Sulfites	11-19	Ssu1p	Saccharomyces cerevisiae S288C	89-93
11921096-5	2002	We also analysed the effect of overexpression of MET14 and MET16 on sulphite formation.	Sulfites	68-76	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	49-54
11921096-5	2002	We also analysed the effect of overexpression of MET14 and MET16 on sulphite formation.	Sulfites	68-76	phosphoadenylyl-sulfate reductase (thioredoxin)	Saccharomyces cerevisiae S288C	59-64
11921096-8	2002	In addition, inactivation of MET10, encoding a subunit of the sulphite reductase, also leads to a distinct increase in sulphite formation; however, the cells became methionine auxotroph.	Sulfites	62-70	sulfite reductase subunit alpha	Saccharomyces cerevisiae S288C	29-34
11921096-9	2002	The overexpression of SSU1, a gene encoding a putative sulphite pump, yields a slight increase in sulphite accumulation, whereas overexpression of SSU1, together with MET14, increases sulphite formation up to 10-fold.	Sulfites	55-63	Ssu1p	Saccharomyces cerevisiae S288C	22-26
11921096-9	2002	The overexpression of SSU1, a gene encoding a putative sulphite pump, yields a slight increase in sulphite accumulation, whereas overexpression of SSU1, together with MET14, increases sulphite formation up to 10-fold.	Sulfites	98-106	Ssu1p	Saccharomyces cerevisiae S288C	22-26
11921096-11	2002	The addition of glucose can also increase the sulphite formation in strains overexpressing MET14 and/or SSU1 under oxygen-limiting conditions, while the addition of glucose has no significant effect under aerobic conditions.	Sulfites	46-54	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	91-96
11921096-11	2002	The addition of glucose can also increase the sulphite formation in strains overexpressing MET14 and/or SSU1 under oxygen-limiting conditions, while the addition of glucose has no significant effect under aerobic conditions.	Sulfites	46-54	Ssu1p	Saccharomyces cerevisiae S288C	104-108
12269282-2	2001	pH dependent reactivity differences of dimethylsulfite towards the title complex 1 demonstrate the crucial need of oxo-anionic coordination of sulfite to the molybdenum centre of 1 in the model reductive half reaction of sulfite oxidase.	Sulfites	47-54	sulfite oxidase	Homo sapiens	221-236
12005182-0	2002	Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).	Sulfites	0-7	fibrinogen beta chain	Homo sapiens	74-84
12005182-0	2002	Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).	Sulfites	0-7	integrin subunit alpha M	Homo sapiens	107-112
12005182-0	2002	Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).	Sulfites	0-7	integrin subunit alpha M	Homo sapiens	129-134
12005182-0	2002	Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).	Sulfites	0-7	integrin subunit beta 2	Homo sapiens	135-139
11557133-3	2001	Two pathways of sulfite oxidation are known: (1) direct oxidation to sulfate catalyzed by a sulfite:acceptor oxidoreductase, which is thought to be a molybdenum-containing enzyme; (2) indirect oxidation under the involvement of the enzymes adenylylsulfate (APS) reductase and ATP sulfurylase and/or adenylylsulfate:phosphate adenylyltransferase with APS as an intermediate.	Sulfites	16-23	SH2B adaptor protein 2	Homo sapiens	257-260
11557133-3	2001	Two pathways of sulfite oxidation are known: (1) direct oxidation to sulfate catalyzed by a sulfite:acceptor oxidoreductase, which is thought to be a molybdenum-containing enzyme; (2) indirect oxidation under the involvement of the enzymes adenylylsulfate (APS) reductase and ATP sulfurylase and/or adenylylsulfate:phosphate adenylyltransferase with APS as an intermediate.	Sulfites	16-23	SH2B adaptor protein 2	Homo sapiens	350-353
10870099-1	2000	Ssu1p, a plasma membrane protein involved in sulphite metabolism in Saccharomyces cerevisiae, was found to be required for efficient sulphite efflux.	Sulfites	45-53	Ssu1p	Saccharomyces cerevisiae S288C	0-5
11073956-0	2001	Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro.	Sulfites	54-61	sulfoquinovosyldiacylglycerol 1	Arabidopsis thaliana	24-28
11073956-5	2001	Among different possible sulfur donors tested, sulfite led to the formation of UDP-sulfoquinovose in the presence of UDP-glucose and SQD1.	Sulfites	47-54	sulfoquinovosyldiacylglycerol 1	Arabidopsis thaliana	133-137
11073956-8	2001	Approximate K(m) values of 150 microm for UDP-glucose and 10 microm for sulfite were established for SQD1.	Sulfites	72-79	sulfoquinovosyldiacylglycerol 1	Arabidopsis thaliana	101-105
11073956-9	2001	Based on our results, we propose that SQD1 catalyzes the formation of UDP-sulfoquinovose from UDP-glucose and sulfite, derived from the sulfate reduction pathway in the chloroplast.	Sulfites	110-117	sulfoquinovosyldiacylglycerol 1	Arabidopsis thaliana	38-42
10878565-9	2000	A significant increase in steady-state calcium levels after stimulation with FMLP was observed after treatment with sulfite in concentrations of 10 and 100 mM.	Sulfites	116-123	formyl peptide receptor 1	Homo sapiens	77-81
10878565-12	2000	Similar results were obtained after preincubation with sulfite before treatment with FMLP, showing that the effect of sulfite on the respiratory burst was additive to the FMLP response.	Sulfites	118-125	formyl peptide receptor 1	Homo sapiens	85-89
10878565-17	2000	5-1 mM), sulfite caused a concentration-dependent increase of [H(2)O(2)](i), in addition to the FMLP-induced response.	Sulfites	9-16	formyl peptide receptor 1	Homo sapiens	96-100
10870099-1	2000	Ssu1p, a plasma membrane protein involved in sulphite metabolism in Saccharomyces cerevisiae, was found to be required for efficient sulphite efflux.	Sulfites	133-141	Ssu1p	Saccharomyces cerevisiae S288C	0-5
10870099-2	2000	An SSU1 null mutant accumulated significantly more sulphite than wild-type, whereas cells expressing multicopy SSU1 accumulated significantly less.	Sulfites	51-59	Ssu1p	Saccharomyces cerevisiae S288C	3-7
10870099-3	2000	Cells expressing FZF1-4, a dominant allele of a transcriptional activator of SSU1 that confers sulphite resistance, also accumulated less sulphite.	Sulfites	95-103	Fzf1p	Saccharomyces cerevisiae S288C	17-23
10870099-3	2000	Cells expressing FZF1-4, a dominant allele of a transcriptional activator of SSU1 that confers sulphite resistance, also accumulated less sulphite.	Sulfites	95-103	Ssu1p	Saccharomyces cerevisiae S288C	77-81
10870099-3	2000	Cells expressing FZF1-4, a dominant allele of a transcriptional activator of SSU1 that confers sulphite resistance, also accumulated less sulphite.	Sulfites	138-146	Fzf1p	Saccharomyces cerevisiae S288C	17-23
10870099-3	2000	Cells expressing FZF1-4, a dominant allele of a transcriptional activator of SSU1 that confers sulphite resistance, also accumulated less sulphite.	Sulfites	138-146	Ssu1p	Saccharomyces cerevisiae S288C	77-81
10870099-5	2000	Multicopy SSU1 was also found to increase the sulphite resistance of a number of unrelated sulphite-sensitive strains by a factor of 3- to 8-fold.	Sulfites	46-54	Ssu1p	Saccharomyces cerevisiae S288C	10-14
10870099-5	2000	Multicopy SSU1 was also found to increase the sulphite resistance of a number of unrelated sulphite-sensitive strains by a factor of 3- to 8-fold.	Sulfites	91-99	Ssu1p	Saccharomyces cerevisiae S288C	10-14
10870099-6	2000	Rates of efflux of free sulphite from cells expressing multicopy SSU1 or FZF1-4 were significantly greater than that from wild-type or from a SSU1 null mutant.	Sulfites	24-32	Ssu1p	Saccharomyces cerevisiae S288C	65-69
10870099-6	2000	Rates of efflux of free sulphite from cells expressing multicopy SSU1 or FZF1-4 were significantly greater than that from wild-type or from a SSU1 null mutant.	Sulfites	24-32	Fzf1p	Saccharomyces cerevisiae S288C	73-77
10870099-6	2000	Rates of efflux of free sulphite from cells expressing multicopy SSU1 or FZF1-4 were significantly greater than that from wild-type or from a SSU1 null mutant.	Sulfites	24-32	Ssu1p	Saccharomyces cerevisiae S288C	142-146
10870099-7	2000	Rates of efflux of bound sulphite from wild-type, a SSU1 null mutant, a FZF1-4 mutant, or cells expressing multicopy SSU1 were not significantly different, suggesting that Ssu1p specifically mediates efflux of the free form of sulphite.	Sulfites	227-235	Ssu1p	Saccharomyces cerevisiae S288C	172-177
10234785-1	1999	The FZF1 gene of Saccharomyces cerevisiae encodes a five-zinc-finger transcription factor involved in sulphite tolerance.	Sulfites	102-110	Fzf1p	Saccharomyces cerevisiae S288C	4-8
10892291-7	2000	Compared to that in the rabbit fed a sulfite-containing diet, sulfonated TTR was decreased on the 7th day of a sulfite-free diet.	Sulfites	37-44	transthyretin	Oryctolagus cuniculus	73-76
10892291-7	2000	Compared to that in the rabbit fed a sulfite-containing diet, sulfonated TTR was decreased on the 7th day of a sulfite-free diet.	Sulfites	111-118	transthyretin	Oryctolagus cuniculus	73-76
10541593-3	1999	Using isoelectric focusing in urea gradients we were able to demonstrate a stabilizing effect of sulfite on TTR monomers and tetramers, as well as an increase in the tetramer/monomer ratio.	Sulfites	97-104	transthyretin	Homo sapiens	108-111
10350486-1	1999	A comprehensive kinetic study of sulfite oxidase has been undertaken over the pH range 6.0-10.0, including conventional steady-state work as well as rapid kinetic studies of both the reaction of oxidized enzyme with sulfite and reduced enzyme with cytochrome c (III).	Sulfites	33-40	cytochrome c, somatic	Gallus gallus	248-260
12552699-2	1999	The strong fluorescent derivatives formed by the quantitative reaction of sulfite in wine and N-(9-acridinyl) maleimide(NAM) in aqueous solution under mild conditions was injected into the HPLC.	Sulfites	74-81	SH3 and cysteine rich domain 3	Homo sapiens	120-123
10524282-3	1999	We previously described a component which had a molecular mass 80 Da larger than free TTR and was proved to be TTR conjugated with sulfite.	Sulfites	131-138	transthyretin	Homo sapiens	86-89
10524282-3	1999	We previously described a component which had a molecular mass 80 Da larger than free TTR and was proved to be TTR conjugated with sulfite.	Sulfites	131-138	transthyretin	Homo sapiens	111-114
9703738-1	1998	Sulfite-alkaline method after Rampling and Gaffney is proposed for measuring fibrinogen and fibrin degradation products in cadaveric blood.	Sulfites	0-7	fibrinogen beta chain	Homo sapiens	77-87
9604330-4	1998	When analyzing real samples, tap and river waters, different quantities of sulphite were added to decrease the initial band due to fulvic and humic acids.	Sulfites	75-83	nuclear RNA export factor 1	Homo sapiens	29-32
9485308-4	1998	This subunit contains FMN as the flavin cofactor which exhibits the properties of Flavin 2 of glutamate synthase: reactivity with sulfite to yield a flavin-N(5)-sulfite addition product (Kd = 2.6 +/- 0.22 mM), lack of reactivity with NADPH, reduction by L-glutamate, and reoxidation by 2-oxoglutarate and glutamine.	Sulfites	130-137	formin 1	Homo sapiens	22-25
9512363-0	1998	Sulphite enhances peroxynitrite-dependent alpha1-antiproteinase inactivation.	Sulfites	0-8	serpin family A member 1	Homo sapiens	42-63
9294463-0	1997	SSU1 encodes a plasma membrane protein with a central role in a network of proteins conferring sulfite tolerance in Saccharomyces cerevisiae.	Sulfites	95-102	Ssu1p	Saccharomyces cerevisiae S288C	0-4
9512363-3	1998	We show that sulphite can considerably potentiate the inactivation of alpha1-antiproteinase caused by peroxynitrite.	Sulfites	13-21	serpin family A member 1	Homo sapiens	70-91
9618940-5	1998	Inhibitors of phospholipase A2 substantially suppressed release of neutrophil-stimulating activity by sulfite-treated AM.	Sulfites	102-109	phospholipase A2 group IB	Canis lupus familiaris	14-30
9618940-7	1998	In conclusion, sulfite induces AM to release lipid mediators via phospholipase A2- and 5-lipoxygenase-dependent pathways.	Sulfites	15-22	phospholipase A2 group IB	Canis lupus familiaris	65-81
9294463-1	1997	The Saccharomyces cerevisiae SSU1 gene was isolated based on its ability to complement a mutation causing sensitivity to sulfite, a methionine intermediate.	Sulfites	121-128	Ssu1p	Saccharomyces cerevisiae S288C	29-33
9224564-7	1997	Sulphite was a competitive inhibitor vs thiosulphate for rhodanese isolated from normal liver and a hyperbolic activator for the enzyme isolated from liver of DAB-treated animals.	Sulfites	0-8	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	57-66
9261082-3	1997	Thioredoxin is used as the electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) and sulphite.	Sulfites	109-117	thioredoxin	Homo sapiens	0-11
8910450-4	1996	The affinity of pyruvate for the reduced enzyme is increased, and sulfite binding to the oxidized enzyme is weaker in A95G-LOX than in native enzyme.	Sulfites	66-73	lysyl oxidase	Rattus norvegicus	123-126
9634827-5	1996	Partial or full elimination of MET10 gene activity in a brewer"s yeast resulted in increased sulfite accumulation.	Sulfites	93-100	sulfite reductase subunit alpha	Saccharomyces cerevisiae S288C	31-36
8889516-0	1996	Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae.	Sulfites	37-44	Fzf1p	Saccharomyces cerevisiae S288C	10-14
8889516-0	1996	Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae.	Sulfites	37-44	sulfate permease	Saccharomyces cerevisiae S288C	16-20
8889516-1	1996	An ssu2 mutation in Saccharomyces cerevisiae, previously shown to cause sulfite sensitivity, was found to be allelic to GRR1, a gene previously implicated in glucose repression.	Sulfites	72-79	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	3-7
8889516-1	1996	An ssu2 mutation in Saccharomyces cerevisiae, previously shown to cause sulfite sensitivity, was found to be allelic to GRR1, a gene previously implicated in glucose repression.	Sulfites	72-79	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	120-124
8889516-4	1996	Overexpression in GRR1 cells resulted in sulfite sensitivity, suggesting a connection between CLN1 and sulfite metabolism.	Sulfites	41-48	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	18-22
8889516-4	1996	Overexpression in GRR1 cells resulted in sulfite sensitivity, suggesting a connection between CLN1 and sulfite metabolism.	Sulfites	41-48	cyclin CLN1	Saccharomyces cerevisiae S288C	94-98
8889516-5	1996	Multicopy FZF1, a putative transcription factor, was found to suppress the sulfite sensitive phenotype of grr1 strains, but not the glucose derepression or aberrant cell morphology.	Sulfites	75-82	Fzf1p	Saccharomyces cerevisiae S288C	10-14
8889516-5	1996	Multicopy FZF1, a putative transcription factor, was found to suppress the sulfite sensitive phenotype of grr1 strains, but not the glucose derepression or aberrant cell morphology.	Sulfites	75-82	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	106-110
8889516-6	1996	Multicopy FZF1 was also found to suppress the sensitivity of a number of other unrelated sulfite-sensitive mutants, but not that of ssu1 or met20, implying that FZF1 may act through Ssu1p and Met20p.	Sulfites	89-96	Fzf1p	Saccharomyces cerevisiae S288C	10-14
8889516-6	1996	Multicopy FZF1 was also found to suppress the sensitivity of a number of other unrelated sulfite-sensitive mutants, but not that of ssu1 or met20, implying that FZF1 may act through Ssu1p and Met20p.	Sulfites	89-96	Fzf1p	Saccharomyces cerevisiae S288C	161-165
8889516-6	1996	Multicopy FZF1 was also found to suppress the sensitivity of a number of other unrelated sulfite-sensitive mutants, but not that of ssu1 or met20, implying that FZF1 may act through Ssu1p and Met20p.	Sulfites	89-96	Ssu1p	Saccharomyces cerevisiae S288C	182-187
8889516-6	1996	Multicopy FZF1 was also found to suppress the sensitivity of a number of other unrelated sulfite-sensitive mutants, but not that of ssu1 or met20, implying that FZF1 may act through Ssu1p and Met20p.	Sulfites	89-96	uroporphyrinogen-III C-methyltransferase	Saccharomyces cerevisiae S288C	192-198
8889516-7	1996	Disruption of FZF1 resulted in sulfite sensitivity when the construct was introduced in single copy at the FZF1 locus in a GRR1 strain, providing evidence that FZF1 is involved in sulfite metabolism.	Sulfites	31-38	Fzf1p	Saccharomyces cerevisiae S288C	14-18
8889516-7	1996	Disruption of FZF1 resulted in sulfite sensitivity when the construct was introduced in single copy at the FZF1 locus in a GRR1 strain, providing evidence that FZF1 is involved in sulfite metabolism.	Sulfites	31-38	Fzf1p	Saccharomyces cerevisiae S288C	107-111
8889516-7	1996	Disruption of FZF1 resulted in sulfite sensitivity when the construct was introduced in single copy at the FZF1 locus in a GRR1 strain, providing evidence that FZF1 is involved in sulfite metabolism.	Sulfites	31-38	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	123-127
8889516-7	1996	Disruption of FZF1 resulted in sulfite sensitivity when the construct was introduced in single copy at the FZF1 locus in a GRR1 strain, providing evidence that FZF1 is involved in sulfite metabolism.	Sulfites	31-38	Fzf1p	Saccharomyces cerevisiae S288C	107-111
8927481-8	1996	The same additives (azo dyes, sulphites, benzoates) are used in various drug formulations and may be responsible for eliciting PAR.	Sulfites	30-39	jumping translocation breakpoint	Homo sapiens	127-130
8987848-4	1996	We expected that inactivation of MET2 would lead to accumulation of sulfide and derepression of the entire sulfur assimilation pathway and, therefore, possibly also to sulfite accumulation.	Sulfites	168-175	homoserine O-acetyltransferase	Saccharomyces cerevisiae S288C	33-37
8987848-6	1996	Sulfite production was increased in strains with one remaining MET2 gene and even more so when no active MET2 was present.	Sulfites	0-7	homoserine O-acetyltransferase	Saccharomyces cerevisiae S288C	63-67
8987848-6	1996	Sulfite production was increased in strains with one remaining MET2 gene and even more so when no active MET2 was present.	Sulfites	0-7	homoserine O-acetyltransferase	Saccharomyces cerevisiae S288C	105-109
7762419-6	1995	Lucigenin-dependent CL of sulphite-treated and subsequently stimulated neutrophils was strongly inhibited by extracellularly added superoxide dismutase, whereas luminol-dependent CL was markedly reduced by the MPO inhibitor azide.	Sulfites	26-34	myeloperoxidase	Homo sapiens	210-213
8599028-6	1996	In presence of HCO3, the expressed Na-HCO3 cotransporter activity was like the native cotransporter, enhanced by carbonate or sulfite, a finding compatible with the existence of distinct sites for HCO3 and carbonate on the transport system.	Sulfites	126-133	solute carrier family 4 member 4	Homo sapiens	35-56
7762419-7	1995	The intracellular activity of MPO in neutrophils stimulated with PMA in the presence of sulphite (2 mmol/L) was reduced by 55%.	Sulfites	88-96	myeloperoxidase	Homo sapiens	30-33
7762419-8	1995	Sulphite (0.1 mmol/L) also inhibited strongly the activity of MPO in a cell-free system.	Sulfites	0-8	myeloperoxidase	Homo sapiens	62-65
7762419-9	1995	These results indicate that micromolar concentrations of sulphite exert a stimulating effect on the O2- production of neutrophils extracellularly, but have an inhibitory effect on MPO-catalysed reactions intracellularly.	Sulfites	57-65	myeloperoxidase	Homo sapiens	180-183
7992510-1	1994	In this paper we describe the cloning and sequencing of the gene (SUL1) responsible for sulphite resistance in a Saccharomyces cerevisiae mutant (Casalone et al., 1992).	Sulfites	88-96	sulfate permease	Saccharomyces cerevisiae S288C	66-70
1425675-5	1992	Sulfite is known to be much more effective than bicarbonate in stimulating ATPase activity CF1.	Sulfites	0-7	dynein axonemal heavy chain 8	Homo sapiens	75-81
8448446-2	1993	The sulfite in liquid foods or extracts of solid foods is analyzed according to the following principle: Sulfite ions are oxidized to sulfate ions by oxygen in the presence of sulfite oxidase, thereby forming hydrogen peroxide.	Sulfites	4-11	LOW QUALITY PROTEIN: sulfite oxidase	Malus domestica	176-191
8448446-2	1993	The sulfite in liquid foods or extracts of solid foods is analyzed according to the following principle: Sulfite ions are oxidized to sulfate ions by oxygen in the presence of sulfite oxidase, thereby forming hydrogen peroxide.	Sulfites	105-112	LOW QUALITY PROTEIN: sulfite oxidase	Malus domestica	176-191
1816051-0	1991	Chemical modification of rhodanese with sulphite.	Sulfites	40-48	thiosulfate sulfurtransferase	Bos taurus	25-34
1828947-9	1991	In contrast to sulfate, the hypothetical transition-state analogues sulfite and vanadate acted as strong inhibitors of the sulfatase activity.	Sulfites	68-75	arylsulfatase family member H	Homo sapiens	123-132
1645541-1	1991	Exposure of albumin to sulfite in the presence of Co(II) or peroxidase/H2O2 caused site-specific fragmentation, which was not due to cleavage of methionyl nor tryptophanyl peptide bonds.	Sulfites	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
1645541-2	1991	The reaction of GlyPro with sulfite in the presence of Co(II) or peroxidase/H2O2 led to Gly liberation, suggesting the oxidative cleavage of protein at Pro residues.	Sulfites	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
1645541-4	1991	ESR-spin trapping method provided evidence for the formation of sulfate radical (SO4.-) during Co(II)-catalyzed autoxidation of sulfite.	Sulfites	128-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
2137348-3	1990	Sulfite activates the ATPase, and many molecules of ATP per synthase can be hydrolyzed before most of the bound [3H]ADP is released, a result interpreted as indicating that the ADP is not bound at a site participating in catalysis by the sulfite-activated enzyme [Larson, E. M., Umbach, A., & Jagendorf, A. T. (1989) Biochim.	Sulfites	0-7	dynein axonemal heavy chain 8	Homo sapiens	22-28
2329585-16	1990	The interaction of Lys349 with atoms N-1 and O-2 of the flavin ring is probably responsible for stabilization of the anionic form of the flavin semiquinone and hydroquinone and enhancing the reactivity of atom N-5 toward sulfite.	Sulfites	221-228	immunoglobulin kappa variable 1D-39	Homo sapiens	37-48
2137348-7	1990	The Mg2(+)- and ADP-inhibited enzyme when exposed to MgATP and 20-100 mM sulfite shows a lag of about 1 min at 22 degrees C and of about 15 s at 37 degrees C before reaching the same steady-state rate as attained with light-activated ATPase that has not been inhibited by Mg2+ and ADP.	Sulfites	73-80	dynein axonemal heavy chain 8	Homo sapiens	234-240
34915296-6	2022	The catalytic mechanism of the NADH oxidase mimics is that O2 involves in the oxidation of NADH, to generate O2.- intermediate and finally turn to H2O2, while SuOx mimics comes from that MoS2 particles can effectively catalyze sulfite to reduce (Fe(CN)6)3-.	Sulfites	227-234	sulfite oxidase	Homo sapiens	159-163
34915296-7	2022	Based on the excellent SuOx-like activity of MoS2 particles, while phenol can inhibit the oxidation of sulfite, a phenol colorimetric sensor was explored with the dynamic range of 2-1000 muM and the limit of detection of 0.72 muM, applicable to detect phenol in effluents.	Sulfites	103-110	sulfite oxidase	Homo sapiens	23-27
34763081-2	2021	SQOR is a mitochondrial membrane-bound protein that catalyzes a two-electron oxidation of H2S to sulfane sulfur (S0), using glutathione (or sulfite) and coenzyme Q (CoQ) as S0 and electron acceptor, respectively.	Sulfites	140-147	sulfide quinone oxidoreductase	Homo sapiens	0-4
34741542-2	2022	SO is a mitochondrially localized molybdenum cofactor (Moco)- and heme-dependent enzyme, which catalyzes the vital oxidation of toxic sulfite to sulfate.	Sulfites	134-141	sulfite oxidase	Homo sapiens	0-2
34762651-3	2021	We found two new heterologous chromosomal translocations in fermentative strains of S. uvarum at the SSU1 locus, involved in sulfite resistance, an antimicrobial additive widely used in food production.	Sulfites	125-132	Ssu1p	Saccharomyces cerevisiae S288C	101-105
34738214-1	2022	This study aimed to investigate the degradability, mineralization, proposed decomposition pathway, intermediate products, and toxicity of effluent from trichlorfon (TCF) degradation in water by UV/sulfite-advanced reduction process (UV/S-ARP).	Sulfites	197-204	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	238-241
34738214-6	2022	UV/S-ARP had the highest performance at an initial pH of 7, a sulfite ion concentration of 120 mg/L, a contact time of 60 min, and a TCF concentration of 10 mg/L.	Sulfites	62-69	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	5-8
34107028-0	2021	APS reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.	Sulfites	43-50	APS reductase 1	Arabidopsis thaliana	0-13
34637277-1	2021	The discovery of sulfite-stabilized anodic current of hydroquinone (HQ) at high pH was used to develop two new methods for measuring the activity of the key biomarker alkaline phosphatase (ALP).	Sulfites	17-24	alkaline phosphatase, placental	Homo sapiens	167-187
34637277-1	2021	The discovery of sulfite-stabilized anodic current of hydroquinone (HQ) at high pH was used to develop two new methods for measuring the activity of the key biomarker alkaline phosphatase (ALP).	Sulfites	17-24	alkaline phosphatase, placental	Homo sapiens	189-192
34107028-8	2021	Suppression of APR by inhibiting NADPH oxidase and glutathione reductase2 (GR2) by diphenyleneiodonium, or mutation in APR2 or GR2, resulted in decrease in sulfite production and stomatal aperture size, further supporting the role of APR in stomatal aperture size.	Sulfites	156-163	APS reductase 1	Arabidopsis thaliana	15-18
34107028-8	2021	Suppression of APR by inhibiting NADPH oxidase and glutathione reductase2 (GR2) by diphenyleneiodonium, or mutation in APR2 or GR2, resulted in decrease in sulfite production and stomatal aperture size, further supporting the role of APR in stomatal aperture size.	Sulfites	156-163	glyoxylate reductase 2	Arabidopsis thaliana	51-73
34107028-8	2021	Suppression of APR by inhibiting NADPH oxidase and glutathione reductase2 (GR2) by diphenyleneiodonium, or mutation in APR2 or GR2, resulted in decrease in sulfite production and stomatal aperture size, further supporting the role of APR in stomatal aperture size.	Sulfites	156-163	glyoxylate reductase 2	Arabidopsis thaliana	75-78
34107028-8	2021	Suppression of APR by inhibiting NADPH oxidase and glutathione reductase2 (GR2) by diphenyleneiodonium, or mutation in APR2 or GR2, resulted in decrease in sulfite production and stomatal aperture size, further supporting the role of APR in stomatal aperture size.	Sulfites	156-163	glyoxylate reductase 2	Arabidopsis thaliana	127-130
34107028-8	2021	Suppression of APR by inhibiting NADPH oxidase and glutathione reductase2 (GR2) by diphenyleneiodonium, or mutation in APR2 or GR2, resulted in decrease in sulfite production and stomatal aperture size, further supporting the role of APR in stomatal aperture size.	Sulfites	156-163	APS reductase 1	Arabidopsis thaliana	234-237
34107028-0	2021	APS reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.	Sulfites	43-50	sulfite oxidase	Arabidopsis thaliana	18-33
34107028-1	2021	Chloroplast-localized adenosine-5"-phosphosulphate reductase (APR) generates sulfite and plays a pivotal role in sulfate reduction to cysteine.	Sulfites	77-84	APS reductase 1	Arabidopsis thaliana	22-60
34107028-9	2021	The importance of APR and SO in the set-up of sulfite level in leaves, and the significance of sulfite level in water loss were further demonstrated during fast and harsh drought stress in root-detached WT, gr2 and SO modified plants.	Sulfites	46-53	APS reductase 1	Arabidopsis thaliana	18-21
34107028-1	2021	Chloroplast-localized adenosine-5"-phosphosulphate reductase (APR) generates sulfite and plays a pivotal role in sulfate reduction to cysteine.	Sulfites	77-84	APS reductase 1	Arabidopsis thaliana	62-65
34107028-2	2021	The peroxisome-localized sulfite oxidase (SO), oxidizes excess sulfite to sulfate.	Sulfites	63-70	sulfite oxidase	Arabidopsis thaliana	25-40
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	45-52	APS reductase 1	Arabidopsis thaliana	17-20
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	45-52	APS reductase 1	Arabidopsis thaliana	183-186
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	118-125	APS reductase 1	Arabidopsis thaliana	17-20
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	118-125	APS reductase 1	Arabidopsis thaliana	183-186
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	212-219	APS reductase 1	Arabidopsis thaliana	17-20
34107028-6	2021	The increases in APR activity in response to sulfite infiltration into WT and SO Ri leaves resulted in an increase in sulfite beyond the level of the applied sulfite, indicating that APR has an important role in sulfite-induced increases in stomatal aperture.	Sulfites	212-219	APS reductase 1	Arabidopsis thaliana	183-186
34107028-7	2021	Notably, sulfite-induced H2O2 generation by NADPH oxidase, led to enhanced APR expression and sulfite production.	Sulfites	9-16	APS reductase 1	Arabidopsis thaliana	75-78
34249061-2	2021	It was also demonstrated that SO activity is essential to cope with rising dark-induced endogenous sulfite levels and maintain optimal carbon and sulfur metabolism in tomato plants exposed to extended dark stress.	Sulfites	99-106	sulfite oxidase	Solanum lycopersicum	30-32