PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12734796-6	2003	Its gene (PDR12) is strongly induced by sorbate, benzoate and certain other moderately lipophilic carboxylate compounds, but not by organic alcohols or high levels of acetate.	Benzoates	49-57	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	10-15
11737636-0	2001	The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives.	Benzoates	183-191	Yme2p	Saccharomyces cerevisiae S288C	6-10
12693212-11	2003	of 6b with acetone forms the methyl enolate complex [Ru2(trpy)2(6,6"-Me2dppz)(CH2COCH3)](PF6)2 (9b) while, analogously to a Cannizarro reaction, the reaction with benzaldehyde forms the bridging benzoate complex [Ru2(trpy)2(6,6"-Me2dppz)(C6H4CO2)](PF6)2 (11b).	Benzoates	195-203	sperm associated antigen 17	Homo sapiens	89-92
12198127-4	2002	BXRalpha can be transactivated by a number of benzoate derivatives including 4-amino-butylbenzoate (4-ABB), 4-hydroxy-butylbenzoate (4-HBB), 3-hydroxy ethyl benzoate (3-HEB), and benzyl benzoate, but only 4-HBB acts as an agonist for both receptors.	Benzoates	46-54	transcription factor 12	Homo sapiens	169-172
12269474-1	2002	Sulfate-reducing bacteria (SRB) HSR1, HSR4, and HSR14 isolated from the salt pans of Goa grew best at 90-100/1000 salinity on substrates like formate, acetate, lactate, butyrate, ethanol and benzoate.	Benzoates	191-199	G protein nucleolar 1 (putative)	Homo sapiens	32-36
12269474-1	2002	Sulfate-reducing bacteria (SRB) HSR1, HSR4, and HSR14 isolated from the salt pans of Goa grew best at 90-100/1000 salinity on substrates like formate, acetate, lactate, butyrate, ethanol and benzoate.	Benzoates	191-199	tripartite motif containing 47	Homo sapiens	85-88
11737636-6	2001	Instead, ZbYme2p has strong similarity to the matrix domain of the S. cerevisiae mitochondrial protein Yme2p/Rna12p/Prp12p and, when expressed as a functional fusion to green fluorescent protein in S. cerevisiae growing on benzoate, is largely localized to mitochondria.	Benzoates	223-231	Yme2p	Saccharomyces cerevisiae S288C	11-16
11158270-7	2001	Results for internal benzoate support the concept of a negatively charged cytoplasmic particle being involved in the ClC-1 gating mechanism sensitive to the internal pH.	Benzoates	21-29	chloride voltage-gated channel 1	Rattus norvegicus	117-122
11504818-4	2001	Ketoprofen, indocyanine green and glibenclamide are potent inhibitors of the uptake of [(14)C]salicylate via rOat2 (K(i) of approximately 12 microM), while diclofenac, benzoate, verapamil, ibuprofen, and tolbutamide are moderate inhibitors (K(i) of approximately 150 microM).	Benzoates	168-176	solute carrier family 22 (organic anion transporter), member 7, pseudogene 1	Rattus norvegicus	109-114
11518528-11	2001	The possible role of benzoate in the antioxidant activity of PRDX5 is discussed.	Benzoates	21-29	peroxiredoxin 5	Homo sapiens	61-66
9540795-1	1998	The XL-I, XL-II and XL-III forms of xenobiotic/medium-chain fatty acid: CoA ligase were found to be inactive toward benzoate in the absence of either monovalent or divalent cations.	Benzoates	116-124	acyl-CoA synthetase medium chain family member 1	Bos taurus	20-26
11196969-2	2000	The benzoate dimers, 1a, show typical dimeric singlet-triplet transitions and strong antiferromagnetic coupling (JST = -206 K (-143 cm-1); H = -2JSTSa.Sb).	Benzoates	4-12	JST	Homo sapiens	113-116
11045454-1	2000	As a potential inhibitor and/or mechanistic probe for lanosterol 14alpha-demethylase, 15alpha-fluoro-24,25-dihydrolanosterol was prepared by fluorination of 15alpha-hydroxy-24,25-dihydrolanost-7-en-3beta-yl benzoate with diethylaminosulfur trifluoride, followed by hydrogen chloride-catalyzed isomerization of the delta7 to delta8 and reductive cleavage of the benzoate.	Benzoates	207-215	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	54-84
10920257-6	2000	The low affinity of homarine (N-methylpicolinate) for oxidized DAO, as in the case of o-methylbenzoate, is due to steric hindrance: one of the ortho carbons of benzoate is near the phenol carbons of Tyr228 and the other ortho carbon is near the carbonyl oxygen of Gly313.	Benzoates	94-102	D-amino acid oxidase	Homo sapiens	63-66
10920257-7	2000	The correlation of the affinity of meta- and para-substituted benzoates for oxidized DAO with their Hammet"s s values are explained by the HOMO-LUMO interaction between the phenol group of Tyr224 and the benzene ring of benzoate derivative.	Benzoates	62-71	D-amino acid oxidase	Homo sapiens	85-88
10920257-7	2000	The correlation of the affinity of meta- and para-substituted benzoates for oxidized DAO with their Hammet"s s values are explained by the HOMO-LUMO interaction between the phenol group of Tyr224 and the benzene ring of benzoate derivative.	Benzoates	62-70	D-amino acid oxidase	Homo sapiens	85-88
10754252-7	2000	Benzoate-grown SK-3 was also able to degrade several Aroclor 1242 congeners without the need for a primary substrate of previous growth on biphenyl.	Benzoates	0-8	potassium calcium-activated channel subfamily N member 3	Homo sapiens	15-19
10761858-0	2000	Expression pattern of BXR suggests a role for benzoate ligand-mediated signalling in hatching gland function.	Benzoates	46-54	nuclear receptor subfamily 1 group I member 2 S homeolog	Xenopus laevis	22-25
10761858-1	2000	The Xenopus laevis nuclear receptor BXR has recently been shown to be activated by a class of endogenous benzoate metabolites, indicating the presence of a novel and unsuspected benzoate ligand-dependent signalling pathway.	Benzoates	105-113	nuclear receptor subfamily 1 group I member 2 S homeolog	Xenopus laevis	36-39
10761858-1	2000	The Xenopus laevis nuclear receptor BXR has recently been shown to be activated by a class of endogenous benzoate metabolites, indicating the presence of a novel and unsuspected benzoate ligand-dependent signalling pathway.	Benzoates	178-186	nuclear receptor subfamily 1 group I member 2 S homeolog	Xenopus laevis	36-39
10711632-2	2000	With benzoate or p-hydroxybenzoate as substrate, the XL-I ligase was essentially inactive in the absence of monovalent cation.	Benzoates	5-13	steroid sulfatase	Homo sapiens	53-57
10482506-12	1999	strain EB1 cells that were grown anaerobically on ethylbenzene, 1-phenylethanol, and acetophenone, but these activities were absent in benzoate-grown cells.	Benzoates	135-143	microtubule associated protein RP/EB family member 1	Homo sapiens	7-10
10493577-8	1999	The benzoate moiety is parallel to the protein surface of PAP and forms only one hydrogen bond with the guanido group of Arg135.	Benzoates	4-12	regenerating family member 3 alpha	Homo sapiens	58-61
10419965-11	1999	Thus, these data provide strong evidence that sorbate and benzoate anions compete with fluorescein for a putative monocarboxylate binding site on the Pdr12 transporter.	Benzoates	58-66	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	150-155
10529005-0	1999	Prenatal melatonin exposure influences the maturation of gonadotropin and prolactin estradiol-benzoate feedback system.	Benzoates	94-102	prolactin	Rattus norvegicus	74-83
11674335-3	1999	Benzoate was introduced as a protecting group at the 1,3-O-disubstituent stage and was removed under basic conditions after the incorporation of the third alkyl group (R(3)) with R(3)X and NaH.	Benzoates	0-8	CD1d molecule	Homo sapiens	168-172
21380913-6	1999	After purifying this intermediate through the formatron of its benzoate, the functionalizatlon of the C-4 and C-5 positions is carried out through an epoxtdation to give two stereoisomers.	Benzoates	63-71	complement C4A (Rodgers blood group)	Homo sapiens	102-105
21380913-6	1999	After purifying this intermediate through the formatron of its benzoate, the functionalizatlon of the C-4 and C-5 positions is carried out through an epoxtdation to give two stereoisomers.	Benzoates	63-71	complement C5	Homo sapiens	110-113
12016856-3	1998	These included taxol derivatives modified at C-2 position with benzoate, m-Cl benzoate, valerate and phenylacetate.	Benzoates	63-71	complement C2	Homo sapiens	45-48
9794920-11	1998	That oatp1 is not a general transporter of anionic compounds was further shown by the lack of transport of harmol sulfate, benzoate, and hippurate.	Benzoates	123-131	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	5-10
9614211-4	1998	Dimethylthiourea or benzoate also decreased the levels of MSR-I mRNA in the presence of the transcription inhibitor actinomycin D.	Benzoates	20-28	progestin and adipoQ receptor family member 7	Homo sapiens	58-61
9573044-0	1998	BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.	Benzoates	83-91	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
9573044-7	1998	Benzoates comprise a new molecular class of nuclear receptor ligand and their activity suggests that BXR may control a previously unsuspected vertebrate signaling pathway.	Benzoates	0-9	nuclear receptor subfamily 1 group I member 2	Homo sapiens	101-104
11004584-4	2000	First of all, intactness of the benzoate moiety of eosin and the negative charge on the carboxylic group of the dye are important factors leading to the specific interaction with alpha-synuclein.	Benzoates	32-40	synuclein alpha	Homo sapiens	179-194
10931353-5	2000	This resistance of the cmk1 mutant is Pdr12 dependent and, unlike with wild-type S. cerevisiae, cmk1 cells are capable of performing Pdr12-specific functions such as energy-dependent cellular extrusion of fluorescein and benzoate.	Benzoates	221-229	calmodulin-dependent protein kinase CMK1	Saccharomyces cerevisiae S288C	23-27
10931353-5	2000	This resistance of the cmk1 mutant is Pdr12 dependent and, unlike with wild-type S. cerevisiae, cmk1 cells are capable of performing Pdr12-specific functions such as energy-dependent cellular extrusion of fluorescein and benzoate.	Benzoates	221-229	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	38-43
10931353-5	2000	This resistance of the cmk1 mutant is Pdr12 dependent and, unlike with wild-type S. cerevisiae, cmk1 cells are capable of performing Pdr12-specific functions such as energy-dependent cellular extrusion of fluorescein and benzoate.	Benzoates	221-229	calmodulin-dependent protein kinase CMK1	Saccharomyces cerevisiae S288C	96-100
10931353-5	2000	This resistance of the cmk1 mutant is Pdr12 dependent and, unlike with wild-type S. cerevisiae, cmk1 cells are capable of performing Pdr12-specific functions such as energy-dependent cellular extrusion of fluorescein and benzoate.	Benzoates	221-229	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	133-138
10434065-4	1999	HXM-A represented 60-80% of the benzoate activity in the lysate, and kinetic analysis revealed that benzoate was the best substrate (highest V(max)/K(m)).	Benzoates	32-40	acyl-CoA synthetase medium chain family member 2B	Homo sapiens	0-5
10434065-4	1999	HXM-A represented 60-80% of the benzoate activity in the lysate, and kinetic analysis revealed that benzoate was the best substrate (highest V(max)/K(m)).	Benzoates	100-108	acyl-CoA synthetase medium chain family member 2B	Homo sapiens	0-5
10941798-8	1999	In accordance with our findings from these studies, two-dimensional gel electrophoretic analysis of extracts of cells grown on benzoate, acetophenone, ethylbenzene, or toluene showed that a number of substrate-specific proteins were induced in strain EbN1.	Benzoates	127-135	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	251-255
10446711-6	1999	Strain DB1 grew on benzoate, dibenzothiophene sulfone, and hexadecanoic acid, but it could not grow on benzofuran, dibenzothiophene, dibenzothiophene sulfoxide, hexadecane, indole, naphthalene, phenol, 2-sulfobenzoic acid, sulfolane, benzothiophene, or 3- or 5-methylbenzothiophenes.	Benzoates	19-27	vascular endothelial zinc finger 1	Homo sapiens	7-10
9870205-11	1998	Serine concentrations were normal in plasma and CSF, but dropped to below normal in CSF in three patients on benzoate treatment.	Benzoates	109-117	colony stimulating factor 2	Homo sapiens	84-87
9792455-2	1998	When peroxynitrite was infused to maintain a 0.9 microM steady-state concentration, plasma made deficient in selenoprotein P diminished benzoate hydroxylation significantly less than control plasma.	Benzoates	136-144	selenoprotein P	Homo sapiens	109-124
9792455-4	1998	Conversely, in a selenoprotein P-enriched plasma preparation obtained via heparin-Sepharose chromatography, protection against benzoate hydroxylation was above controls.	Benzoates	127-135	selenoprotein P	Homo sapiens	17-32
9514608-7	1998	Conclusively, it is considered that the hydroxyl groups of alkaloids, especially a free OH group of 2 at C-6, are important for action on the peripheral vasculature leading to dilatation, and these results indicated that esterification of the hydroxyl group at C-15 with either acetate or benzoate may contribute to enhancement of the activity of the parent alkaloids.	Benzoates	289-297	complement component 6	Mus musculus	105-108
8927481-8	1996	The same additives (azo dyes, sulphites, benzoates) are used in various drug formulations and may be responsible for eliciting PAR.	Benzoates	41-50	jumping translocation breakpoint	Homo sapiens	127-130
7636843-4	1995	We report here structural modifications of the benzoate moiety of 2 that result in analogs with greater RXR selectivity as well as those with pan-agonist (activate both RAR and RXR receptors) activities, analyze the structural features that impart receptor selectivity, and describe a stereoselective method for the synthesis of these analogs.	Benzoates	47-55	retinoid X receptor alpha	Homo sapiens	104-107
8755502-4	1996	We have solved the crystal structure of the complex of D-amino acid oxidase with benzoate, a competitive inhibitor of the substrate, by single isomorphous replacement and eightfold averaging.	Benzoates	81-89	D-amino acid oxidase	Homo sapiens	55-75
8681967-2	1996	A new semi-synthetic oxidase, N6-(6-carbamoylhexyl)-FAD-D-amino acid oxidase, was prepared by reacting the succinimido ester of N6-(6-carboxyhexyl)-FAD with apo-D-amino-acid oxidase from pig kidney in the presence of benzoate.	Benzoates	217-225	D-amino acid oxidase	Sus scrofa	161-181
8636038-1	1996	Growth of Pseudomonas putida (pWWO) on alkylbenzoates requires the expression of the meta pathway operon, which is mediated by the XylS protein after binding of a benzoate effector.	Benzoates	44-52	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	131-135
8636038-2	1996	Alternatively, in cells growing on toluene or its aromatic alcohols, overexpression of xylS mediated by XylR activated by these compounds leads to overproduction of the XylS regulator, which even in the absence of benzoate effectors stimulates transcription from the meta cleavage pathway operon promoter.	Benzoates	214-222	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	87-91
8636038-2	1996	Alternatively, in cells growing on toluene or its aromatic alcohols, overexpression of xylS mediated by XylR activated by these compounds leads to overproduction of the XylS regulator, which even in the absence of benzoate effectors stimulates transcription from the meta cleavage pathway operon promoter.	Benzoates	214-222	xylose operon regulatory protein	Pseudomonas putida	104-108
8884467-5	1996	Studies of salicylate inhibition of XL-I, XL-II, and XL-III revealed that it inhibited the benzoate activity of all three forms with K1 values of ca.	Benzoates	91-99	acyl-CoA synthetase medium chain family member 1	Bos taurus	53-59
7642499-9	1995	Cells grown on benzoate remained Tol+ but were C23O- and contained a plasmid of reduced size or were plasmid free, suggesting an alternate chromosomal catabolic pathway, also defective in variants.	Benzoates	15-23	catechol 2,3-dioxygenase	Pseudomonas putida	47-51
1737378-1	1992	We investigated the effects of a benzoate of an estradiol-chlorambucil conjugate (KM2210) and chlorambucil on growth, estrogen receptor, and secretion of transforming growth factor (TGF)-alpha in the hormone-dependent human breast cancer cell line MCF-7.	Benzoates	33-41	transforming growth factor alpha	Homo sapiens	182-192
7757200-12	1995	LADH inhibited deoxyribose oxidation and benzoate hydroxylation by Cu(II)/H2O2.	Benzoates	41-49	dihydrolipoamide dehydrogenase	Sus scrofa	0-4
7969028-1	1994	The toluate catabolic operon carried by the TOL plasmid pWW0 of Pseudomonas putida is positively regulated by the benzoate-responsive XylS protein which, when activated, stimulates transcription from the operon promoter Pm.	Benzoates	114-122	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	134-138
7944370-5	1994	Results obtained from experiments with dense cell suspensions of strain Cat2 demonstrated that all enzymes necessary for protocatechuate and benzoate degradation were induced during growth with catechol.	Benzoates	141-149	solute carrier family 7 member 2	Homo sapiens	72-76
7944370-13	1994	Key reactions described for anaerobic degradation of benzoate were catalyzed by cell extracts of strain Cat2, too.	Benzoates	53-61	solute carrier family 7 member 2	Homo sapiens	104-108
8071244-1	1994	The Pm promoter of the meta cleavage operon in the TOL (toluene degradation) plasmid pWW0 of Pseudomonas putida becomes activated by the plasmid-encoded XylS regulator in the presence of benzoate and certain substituted analogs such as 3-methylbenzoate.	Benzoates	187-195	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	153-157
8071244-3	1994	XylS-independent induction by benzoate did not occur in a rpoN genetic background.	Benzoates	30-38	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	0-4
8071244-7	1994	One of them is XylS, while the other, provided by the host bacterium, could be related to the chromosome-encoded benzoate degradation pathway.	Benzoates	113-121	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	15-19
8344270-3	1993	We constructed pWW0 mutants defective in the xylT gene, and found that these mutants were not able to grow on p-toluate while they were still capable of growing on benzoate and m-toluate.	Benzoates	164-172	ferredoxin	Pseudomonas putida	45-49
8355261-1	1993	When bovine kidney mitochondria were assayed in the presence of Triton X-100, they were found to contain glycine N-acyltransferase activity toward the CoA-adducts of benzoate, butyrate, isovalerate, naphthylacetate, phenylacetate, and salicylate.	Benzoates	166-174	glycine N-acyltransferase	Bos taurus	105-130
8424807-8	1993	However, the results suggest that many of the metabolite changes observed following higher doses of benzoate could be due to depletion of ATP, free CoA and acetyl CoA levels, possibly secondary to benzoyl CoA accumulation.	Benzoates	100-108	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	163-166
8424807-8	1993	However, the results suggest that many of the metabolite changes observed following higher doses of benzoate could be due to depletion of ATP, free CoA and acetyl CoA levels, possibly secondary to benzoyl CoA accumulation.	Benzoates	100-108	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	163-166
1550349-10	1992	The antioxidants mannitol and benzoate, as well as the iron chelator deferoxamine, reduced the extent of TNF alpha-induced oxidant effects in hepatocytes, which indicates that the oxidant stress may involve hydroxyl radical generation.	Benzoates	30-38	tumor necrosis factor	Mus musculus	105-114
1351830-10	1992	The intestinal D-met-oxidizing activity is dramatically altered by the D-amino acid oxidase specific inhibitor benzoate.	Benzoates	111-119	D-amino-acid oxidase	Gallus gallus	71-91
8424807-8	1993	However, the results suggest that many of the metabolite changes observed following higher doses of benzoate could be due to depletion of ATP, free CoA and acetyl CoA levels, possibly secondary to benzoyl CoA accumulation.	Benzoates	100-108	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	148-151
2208192-4	1990	Conversion of 8 and 15 to their 2",4"-bis(trifluoromethanesulfonates), followed by SN2 reaction with benzoate, gave the corresponding beta-D-mannopyranosyl disaccharides.	Benzoates	101-109	solute carrier family 38 member 5	Homo sapiens	83-86
1979077-1	1990	In order to obtain further information on the structure of D-amino acid oxidase (EC 1.4.3.3), limited proteolysis experiments have been carried out on its apo-, holo-, and holoenzyme-benzoate forms.	Benzoates	183-191	D-amino acid oxidase	Sus scrofa	59-79
2575901-3	1989	Benzoate-induced glutamate efflux from the liver was not dependent on the concentration (0-1 mM) of ammonia (NH3 + NH4+) in the influent perfusate, but was significantly increased after inhibition of glutamine synthetase by methionine sulphoximine or during the metabolism of added glutamine (5 mM).	Benzoates	0-8	glutamate-ammonia ligase	Rattus norvegicus	200-220
1975807-2	1990	The affinity of trigonelline for DAO in the deprotonated state at the enzyme bound FAD 3-imino group is higher than in the neutral state, contrary to in the case of benzoate, which is a competitive inhibitor and is in a monoanionic form.	Benzoates	165-173	D-amino acid oxidase	Homo sapiens	33-36
33803916-11	2021	The in vitro kinetic analyses of the effect of the 156Asn > Ser,199Arg > Cys variant on human GLYAT enzyme activity indicated that individuals with this haplotype might have a decreased ability to metabolise benzoate when compared to individuals with the 156Asn > Ser variant.	Benzoates	208-216	glycine-N-acyltransferase	Homo sapiens	94-99
34160136-0	2021	Ir(III)-Catalyzed Diarylation/Annulation of Benzoic Acids: Facile Access to Multi-Aryl Spirobifluorenes as Pure Hydrocarbon Hosts for High-Performance OLEDs.	Benzoates	44-57	insulin receptor	Homo sapiens	0-7
34878536-8	2022	Stratification by PN status within obese individuals identified differences in polyamine, purine biosynthesis, and benzoate metabolism.	Benzoates	115-123	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	18-20
35050271-8	2022	Catalytic studies with the cobalt(II)-acetonitrile complex ((6-Me3-TPA)CoII(CH3CN)2)(ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions.	Benzoates	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
3182775-7	1988	Exchange of medium chloride with benzoate or isethionate significantly inhibited the stimulated release of prolactin (IC50 at approximately 60 mM exchange) regardless of the secretagogue utilized (phorbol ester, forskolin, depolarization plus BAY K8644, or TRH).	Benzoates	33-41	prolactin	Rattus norvegicus	107-116
2704028-3	1989	The structure-activity relationships of (E)-chalcone-4-carboxylic acids, which are retinoidal benzoic acids represented by R-Ph-X-Ph-COOH (4, X = -COCH = CH-), are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60.	Benzoates	94-107	cochlin	Homo sapiens	147-151
2775312-7	1989	In whole animals, inhibition of pyruvate carboxylase may contribute to benzoate toxicity and the adverse influence of glyoxylate on benzoate therapy.	Benzoates	71-79	pyruvate carboxylase	Homo sapiens	32-52
2775312-7	1989	In whole animals, inhibition of pyruvate carboxylase may contribute to benzoate toxicity and the adverse influence of glyoxylate on benzoate therapy.	Benzoates	132-140	pyruvate carboxylase	Homo sapiens	32-52
2492793-9	1989	Results support the interpretation that the observed inhibition of pyruvate carboxylase occurred primarily by depletion of the activator, acetyl CoA, through sequestration of coenzyme A during benzoate metabolism.	Benzoates	193-201	pyruvate carboxylase	Homo sapiens	67-87
3182775-7	1988	Exchange of medium chloride with benzoate or isethionate significantly inhibited the stimulated release of prolactin (IC50 at approximately 60 mM exchange) regardless of the secretagogue utilized (phorbol ester, forskolin, depolarization plus BAY K8644, or TRH).	Benzoates	33-41	thyrotropin releasing hormone	Rattus norvegicus	257-260
2904274-7	1988	The in vitro translation product of the capped RNA transcript showed significant catalytic activity, which was inhibited strongly by benzoate, a potent inhibitor of DAO.	Benzoates	133-141	D-amino acid oxidase	Sus scrofa	165-168
3950915-1	1986	Twenty-seven substituted benzoic acids have been studied as inhibitors of partially purified human renal thiopurine methyltransferase (TPMT).	Benzoates	25-38	thiopurine S-methyltransferase	Homo sapiens	105-133
16347699-1	1988	Acetate inhibited benzoate degradation by a syntrophic coculture of an anaerobic benzoate degrader (strain BZ-2) and Methanospirillum strain PM-1; the apparent K(i) for acetate was approximately 40 mM.	Benzoates	18-26	transmembrane protein 11	Homo sapiens	141-145
2885027-1	1987	The reaction of O-(2,4-dinitrophenyl)hydroxylamine with D-amino-acid oxidase leads to complete inactivation which can be protected against by the competitive inhibitor benzoate [D"Silva, C., Williams, C. H., Jr., & Massey, V. (1986) Biochemistry 25, 5602-5608].	Benzoates	168-176	D-amino acid oxidase	Homo sapiens	56-76
2885027-3	1987	Differential high-performance liquid chromatography mapping of tryptic digests of D-amino-acid oxidase modified in the absence and presence of benzoate allows the isolation of a single methionine-containing tryptic peptide corresponding to residues 100-115 and referred to as T6-T7.	Benzoates	143-151	D-amino acid oxidase	Homo sapiens	82-102
2885314-6	1987	However, when the reconstituted DAO was complexed with o-, m-, p-aminobenzoate, or benzoate, each of the four 13C-signals underwent a different change in chemical shift.	Benzoates	70-78	D-amino acid oxidase	Homo sapiens	32-35
6134550-2	1983	The reduction of D-amino acid oxidase (DAAO) by hydrated electrons (eaq-) has been studied in the absence and presence of benzoate by pulse radiolysis.	Benzoates	122-130	D-amino acid oxidase	Homo sapiens	39-43
3023186-1	1986	The xylS gene is a regulatory gene which positively controls expression of the genes on the TOL plasmid for degradation enzymes of benzoate or m-toluate in Pseudomonas putida.	Benzoates	131-139	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	4-8
2995796-5	1985	and/or 1O2 scavengers (benzoate, 1,4-diazo-bicyclo-2,2,2-octane or xanthine) caused a marked increase in enzyme release and a decrease in the generation of active-oxygen species except O-2 and H2O2.	Benzoates	23-31	immunoglobulin kappa variable 1D-39	Homo sapiens	185-188
6428267-11	1984	In a single trial, the enzyme citrate synthase was recovered from the benzoate column with 92% retention of enzymatic activity.	Benzoates	70-78	citrate synthase	Homo sapiens	30-46
3002788-8	1986	When added 10 min after glucose, benzoate caused a rapid (within 2-3 min) decrease in fructose 2,6-bisphosphate concentration and in 6-phosphofructo-2-kinase activity.	Benzoates	33-41	6-phosphofructo-2-kinase	Saccharomyces cerevisiae S288C	133-157
3002788-10	1986	Purified 6-phosphofructo-2-kinase was inhibited by benzoate and also by an acid pH.	Benzoates	51-59	6-phosphofructo-2-kinase	Saccharomyces cerevisiae S288C	9-33
2857720-0	1985	Thermodynamic control of D-amino acid oxidase by benzoate binding.	Benzoates	49-57	D-amino acid oxidase	Homo sapiens	25-45
2857720-6	1985	On the other hand, the behavior of the benzoate-bound enzyme under the same conditions is in marked contrast to the thermodynamics of free D-amino acid oxidase.	Benzoates	39-47	D-amino acid oxidase	Homo sapiens	139-159
2857720-7	1985	Spectroelectrochemical experiments performed on inhibitor-bound (benzoate) D-amino acid oxidase show that benzoate binding regulates the redox properties of the enzyme, causing the energy levels of the benzoate-bound enzyme to be consistent with the two-electron transfer catalytic function of the enzyme.	Benzoates	65-73	D-amino acid oxidase	Homo sapiens	75-95
2857720-7	1985	Spectroelectrochemical experiments performed on inhibitor-bound (benzoate) D-amino acid oxidase show that benzoate binding regulates the redox properties of the enzyme, causing the energy levels of the benzoate-bound enzyme to be consistent with the two-electron transfer catalytic function of the enzyme.	Benzoates	106-114	D-amino acid oxidase	Homo sapiens	75-95
2857720-7	1985	Spectroelectrochemical experiments performed on inhibitor-bound (benzoate) D-amino acid oxidase show that benzoate binding regulates the redox properties of the enzyme, causing the energy levels of the benzoate-bound enzyme to be consistent with the two-electron transfer catalytic function of the enzyme.	Benzoates	106-114	D-amino acid oxidase	Homo sapiens	75-95
6134550-5	1983	Subsequently, the benzoate anion radical transferred an electron to the complex of DAAO-benzoate to form the red semiquinone of the enzyme with a second-order rate constant of 1.2 X 10(9) M-1 s-1 at pH 8.3.	Benzoates	18-26	D-amino acid oxidase	Homo sapiens	83-87
6134550-8	1983	In addition, the rate was found to be identical with that of the formation of the complex between benzoate and the red semiquinone of DAAO as measured by a stopped-flow method.	Benzoates	98-106	D-amino acid oxidase	Homo sapiens	134-138
6134550-9	1983	This suggests that bound benzoate dissociates after the reduction of the benzoate-DAAO complex by benzoate anion radical and that free benzoate subsequently recombines with the red semiquinone of the enzyme to form the blue semiquinone.	Benzoates	25-33	D-amino acid oxidase	Homo sapiens	82-86
6134550-9	1983	This suggests that bound benzoate dissociates after the reduction of the benzoate-DAAO complex by benzoate anion radical and that free benzoate subsequently recombines with the red semiquinone of the enzyme to form the blue semiquinone.	Benzoates	73-81	D-amino acid oxidase	Homo sapiens	82-86
6134550-9	1983	This suggests that bound benzoate dissociates after the reduction of the benzoate-DAAO complex by benzoate anion radical and that free benzoate subsequently recombines with the red semiquinone of the enzyme to form the blue semiquinone.	Benzoates	73-81	D-amino acid oxidase	Homo sapiens	82-86
6121792-1	1981	The resonance Raman (RR) spectra of the complexes of D-amino acid oxidase (DAO) with benzoate derivatives were measured.	Benzoates	85-93	D-amino acid oxidase	Homo sapiens	53-73
6121792-1	1981	The resonance Raman (RR) spectra of the complexes of D-amino acid oxidase (DAO) with benzoate derivatives were measured.	Benzoates	85-93	D-amino acid oxidase	Homo sapiens	75-78
6121792-2	1981	The RR spectra of complexes of DAO with benzoate derivatives excited at 514.5 nm are similar to one another and also similar to that of oxidized flavin.	Benzoates	40-48	D-amino acid oxidase	Homo sapiens	31-34
6121792-3	1981	In the cases of DAO-o-NH2-benzoate and DAO-o-OH-benzoate complexes, however, the line at 568 or 565 cm-1, derived from the benzoate derivative, was intensified.	Benzoates	26-34	D-amino acid oxidase	Homo sapiens	16-19
7026238-2	1981	The interaction of decanoate and benzoate with the substrate-binding site in liver alcohol dehydrogenase has been characterized by fluorimetric equilibrium binding studies, using auramine O as a receptor ligand.	Benzoates	33-41	aldo-keto reductase family 1 member A1	Homo sapiens	83-104
6118269-10	1981	The presence of benzoate, while it prevents the loss of activity, reduces by one the number of arginine residues hit by the reagent in the reaction of 1,2-cyclohexanedione with D-amino acid oxidase.	Benzoates	16-24	D-amino acid oxidase	Homo sapiens	177-197
211851-3	1978	CL is inhibited by superoxide dismutase, an enzyme which catalyzes the conversion of O2- to hydrogen peroxide (H2O2), by catalase, an enzyme which destroys H2O2, and by the hydroxyl radical (.OH) scavengers, benzoate and ethanol.	Benzoates	208-216	catalase	Oryctolagus cuniculus	121-129
6894755-10	1981	NADPH binding to 8-mercapto old yellow enzyme and benzoate binding to 8-Cl-D-amino acid oxidase results in complete blockage of previously available position 8.	Benzoates	50-58	D-amino acid oxidase	Homo sapiens	75-95
7229910-1	1980	The acidic compounds, such as phenoxyacetic acids, substituted benzoic acids, or acetylsalicylic acid, were found to bind to bovine serum albumin (BSA).	Benzoates	63-76	albumin	Rattus norvegicus	132-145
403961-1	1977	A review is given on mechanisms of hydroxylation (the introduction of the first hydroxyl group into C-2 and C-4 positions of cinnamic and benzoic acids; the introduction of the second and the third hydroxyl groups into molecules of phenolcarboxylic acids and flavonoids), dehydrogenation (with participation of phenol oxydase and peroxydase) and deep oxidative degradation of phenolic compounds in plant tissues and cell cultures.	Benzoates	138-151	complement C4A (Rodgers blood group)	Homo sapiens	108-111
19047-1	1977	The kinetic and equilibrium dissociation constants of the reversible binding of benzoate to hog kidney D-amino acid oxidase (DAAO) were studied at 19 degrees C over the pH range 5.3-10.5 by means of a stopped-flow apparatus and spectrophotometric titrations.	Benzoates	80-88	D-amino acid oxidase	Homo sapiens	125-129
679070-0	1978	The microbial degradation of cyclohexanecarboxylic acid by a beta-oxidation pathway with simultaneous induction to the utilization of benzoate.	Benzoates	134-142	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	59-65
24475-2	1978	D-Amino acid oxidase (D-amino acid: oxygen oxidoreductase (deaminating), EC 1.4.3.3) apoenzyme, holoenzyme and the enzyme-benzoate complex were active and stable when immobilized to aminoalkyl or carboxyalkyl agarose, or to cyanogen bromide-activated agarose.	Benzoates	122-130	D-amino acid oxidase	Homo sapiens	0-20
19047-0	1977	Effect of pH on the interaction of benzoate and D-amino acid oxidase.	Benzoates	35-43	D-amino acid oxidase	Homo sapiens	48-68
19047-1	1977	The kinetic and equilibrium dissociation constants of the reversible binding of benzoate to hog kidney D-amino acid oxidase (DAAO) were studied at 19 degrees C over the pH range 5.3-10.5 by means of a stopped-flow apparatus and spectrophotometric titrations.	Benzoates	80-88	D-amino acid oxidase	Homo sapiens	103-123
236295-6	1975	The values of P were extimated to be 0.04, 0.4, and 0.4 for FAD, the enzyme and the enzyme-benzoate complex, respectively.	Benzoates	91-99	FA complementation group D2	Homo sapiens	60-63
1237275-1	1975	Substituted phenols were found to be more potent inhibitors of histidine decarboxylase than were the correspondingly-substituted benzoic acids.	Benzoates	129-142	histidine decarboxylase	Homo sapiens	63-86
33406269-0	2021	Brain activity of benzoate, a D-amino acid oxidase inhibitor, in patients with mild cognitive impairment in a randomized, double-blind, placebo controlled clinical trial.	Benzoates	18-26	D-amino acid oxidase	Homo sapiens	30-50
5461769-2	1970	Aromatic compounds like chlorpromazine and benzoate and its homologs strongly enhance the rate of heat denaturation of myoglobin.	Benzoates	43-51	myoglobin	Homo sapiens	119-128
33881530-9	2021	Among 62 women, 6-week benzoate treatment significantly surpassed placebo in the effects on ADAS-cog performance (mean [SD] difference in score between baseline and end point, -3.1 [6.4] points vs 0 [4.5] points; Cohen d = 0.56; P = .04) but not BEHAVE-AD performance.	Benzoates	23-31	alkylglycerone phosphate synthase	Homo sapiens	92-96
32743799-11	2020	Although exogenous benzoate and cinnamate impact glycine levels via activity of glycine-N-acyltransferase, that is not expressed in brain, they are sufficient to lower levels of glycine and derivatives in brain tissue of treated Gldc-deficient mice.	Benzoates	19-27	glycine-N-acyltransferase	Mus musculus	80-105
33721275-6	2021	The similar photochemical transformation was observed in the photolysis of 2-(2-(4-nitrophenyl)-1H-indol-1-yl)acetic acid, in which the benzoate group is not attached at the nitrophenyl ring.	Benzoates	136-144	indoleamine 2,3-dioxygenase 2	Homo sapiens	99-106
32608135-0	2020	On the Structure and Chiral Aggregation of Liquid Crystalline Star-Shaped Triazines H-Bonded to Benzoic Acids.	Benzoates	96-109	steroidogenic acute regulatory protein	Homo sapiens	62-66
32608135-1	2020	The ability of a star-shaped tris(triazolyl)triazine derivative to hierarchically build supramolecular chiral columnar organizations through the formation of 1:3 H-bonded complexes with benzoic acids was studied from a theoretical and experimental point of view.	Benzoates	186-199	steroidogenic acute regulatory protein	Homo sapiens	17-21
32608135-2	2020	Although the star-shaped triazine core crystallizes in a non- C 3 conformation, the C 3 -symmetric conformation is theoretically predicted to be more stable and gives rise to a favourable C 3 supramolecular 1:3 complex upon the interaction with three benzoic acids in their voids.	Benzoates	251-264	steroidogenic acute regulatory protein	Homo sapiens	13-17
33220246-10	2021	Fe(III)-citrate also stimulated the growth of Syntrophus capable of degrading phenol/benzoate into acetate and proceeding direct interspecies electron transfer (DIET).	Benzoates	85-93	general transcription factor IIE subunit 1	Homo sapiens	0-7
33424832-9	2020	Also, benzoate metabolites of BRBs, such as hippurate, upregulated Smad4 and Gzmb expression that might enhance the cytotoxicity of primary human NK cells.	Benzoates	6-14	SMAD family member 4	Homo sapiens	67-72
33424832-9	2020	Also, benzoate metabolites of BRBs, such as hippurate, upregulated Smad4 and Gzmb expression that might enhance the cytotoxicity of primary human NK cells.	Benzoates	6-14	granzyme B	Homo sapiens	77-81
32743799-11	2020	Although exogenous benzoate and cinnamate impact glycine levels via activity of glycine-N-acyltransferase, that is not expressed in brain, they are sufficient to lower levels of glycine and derivatives in brain tissue of treated Gldc-deficient mice.	Benzoates	19-27	glycine decarboxylase	Mus musculus	229-233
32423674-2	2020	High hydrostatic pressure (HHP) stabilized the aniline-, and benzoate-modified GOx at 69.1-80  C compared to atmospheric pressure.	Benzoates	61-69	hydroxyacid oxidase 1	Homo sapiens	79-82
32903271-5	2020	Decreased glycine in the HeLa cell-based xenograft tumors with knocked down SHMT2 was potentiated by administration of the anti-hyperglycinemia agent benzoate.	Benzoates	150-158	serine hydroxymethyltransferase 2	Homo sapiens	76-81
32423674-5	2020	Furthermore, at 240 MPa and 80.0  C, the kinact of the aniline-modified GOx was 69 times smaller than the kinact of native GOx (1530 x 10-2 min-1) at 0.1 MPa and 80.0  C. Similar results were obtained for benzoate-modified GOx.	Benzoates	205-213	hydroxyacid oxidase 1	Homo sapiens	72-75
32423674-6	2020	At each temperature in this study (25-69.1  C), the catalytic activity of the native, aniline-, or benzoate-modified GOx increased with HHP, and reached a maximum at around 180 MPa.	Benzoates	99-107	hydroxyacid oxidase 1	Homo sapiens	117-120
32423674-7	2020	At 180 MPa and 69.1  C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx.	Benzoates	94-102	hydroxyacid oxidase 1	Homo sapiens	41-44
32423674-7	2020	At 180 MPa and 69.1  C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx.	Benzoates	94-102	hydroxyacid oxidase 1	Homo sapiens	112-115
32423674-7	2020	At 180 MPa and 69.1  C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx.	Benzoates	94-102	hydroxyacid oxidase 1	Homo sapiens	112-115
32093316-0	2020	Binding Constants of Substituted Benzoic Acids with Bovine Serum Albumin.	Benzoates	33-46	albumin	Homo sapiens	59-72
32110025-2	2020	A 24-week study demonstrated that sodium benzoate, a D-amino acid oxidase (DAAO) inhibitor, surpassed placebo in improving cognitive function in early-phase Alzheimer"s disease; however, benzoate did not excel placebo in another 6-week study on BPSD.	Benzoates	41-49	D-amino acid oxidase	Homo sapiens	53-73
32110025-2	2020	A 24-week study demonstrated that sodium benzoate, a D-amino acid oxidase (DAAO) inhibitor, surpassed placebo in improving cognitive function in early-phase Alzheimer"s disease; however, benzoate did not excel placebo in another 6-week study on BPSD.	Benzoates	41-49	D-amino acid oxidase	Homo sapiens	75-79
32110025-7	2020	Results: After benzoate treatment, DAAO inhibition was correlated with ADAS-cog decrease (p = 0.034), while baseline DAAO level was correlated with baseline BEHAVE-AD score.	Benzoates	15-23	D-amino acid oxidase	Homo sapiens	35-39
32110025-7	2020	Results: After benzoate treatment, DAAO inhibition was correlated with ADAS-cog decrease (p = 0.034), while baseline DAAO level was correlated with baseline BEHAVE-AD score.	Benzoates	15-23	alkylglycerone phosphate synthase	Homo sapiens	71-75
32110025-8	2020	Multiple linear regression analyses showed that cognitive improvement after benzoate treatment was correlated with DAAO decrease, female gender, younger age, BMI, baseline BPSD severity, and antipsychotic use.	Benzoates	76-84	D-amino acid oxidase	Homo sapiens	115-119
31803978-2	2020	Herein, we report one-pot synthesis of a three-dimensional (3D) cucurbit[7]uril (Q[7])-based MORF under hydrothermal conditions, namely Q[7]-MORF-1, formed by encapsulating the anionic benzoate moieties of the tricarboxylate ligand into the cavity of Q[7].	Benzoates	185-193	lysine acetyltransferase 6B	Homo sapiens	93-97
31803978-2	2020	Herein, we report one-pot synthesis of a three-dimensional (3D) cucurbit[7]uril (Q[7])-based MORF under hydrothermal conditions, namely Q[7]-MORF-1, formed by encapsulating the anionic benzoate moieties of the tricarboxylate ligand into the cavity of Q[7].	Benzoates	185-193	lysine acetyltransferase 6B	Homo sapiens	141-145
30911576-7	2019	Profiles from PARK2 patients showed significantly higher levels of fatty acid (FA) metabolites and oxidized lipids, and significantly lower levels of antioxidant, caffeine, and benzoate-related metabolites.	Benzoates	177-185	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	14-19
32055740-8	2020	In addition, the expression of some genes involved in cell cycle, protein quality control, and neurotransmission such as cyclin D1, HSP70, and ACHE genes was differentially expressed in the presence of these chemicals, most noticeably in treatment of VB.	Benzoates	251-253	cyclin D1	Homo sapiens	121-130
32055740-8	2020	In addition, the expression of some genes involved in cell cycle, protein quality control, and neurotransmission such as cyclin D1, HSP70, and ACHE genes was differentially expressed in the presence of these chemicals, most noticeably in treatment of VB.	Benzoates	251-253	heat shock protein family A (Hsp70) member 4	Homo sapiens	132-137
32055740-8	2020	In addition, the expression of some genes involved in cell cycle, protein quality control, and neurotransmission such as cyclin D1, HSP70, and ACHE genes was differentially expressed in the presence of these chemicals, most noticeably in treatment of VB.	Benzoates	251-253	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
30861344-6	2019	By using benzoate as a product surrogate that inhibits UbiC without activating the biosensor, we were able to efficiently create and screen a diversified library for UbiC variants with reduced product inhibition.	Benzoates	9-17	chorismate lyase	Pseudomonas putida KT2440	55-59
30861344-6	2019	By using benzoate as a product surrogate that inhibits UbiC without activating the biosensor, we were able to efficiently create and screen a diversified library for UbiC variants with reduced product inhibition.	Benzoates	9-17	chorismate lyase	Pseudomonas putida KT2440	166-170
31799256-2	2019	Here, we focused on arginine 120, a residue located at the protein interface, 20 A from the assumed second ligand-binding site, showing a different orientation of the side chain in the hDAAO-benzoate complex, and corresponding to Ser119 in rat DAAO, which is part of a putative nuclear translocation signal (NTS).	Benzoates	191-199	D-amino acid oxidase	Homo sapiens	185-190
31799256-2	2019	Here, we focused on arginine 120, a residue located at the protein interface, 20 A from the assumed second ligand-binding site, showing a different orientation of the side chain in the hDAAO-benzoate complex, and corresponding to Ser119 in rat DAAO, which is part of a putative nuclear translocation signal (NTS).	Benzoates	191-199	D-amino-acid oxidase	Rattus norvegicus	186-190
31575658-3	2019	One Brassicaceae-specific clade of GH3 proteins was predicted to use benzoate as a substrate and includes AtGH3.7 and AtGH3.12/PBS3.	Benzoates	69-77	Auxin-responsive GH3 family protein	Arabidopsis thaliana	127-131
31339119-8	2019	The crystal structure of 6 reveals an ionic and di-nuclear benzoate species composed of a cationic moiety formulated as [(C83CBiIBTP)Co2(O2CC6H5)2]+ and a counterbalanced perchlorate anion, and both metal atoms are attributed to hexa-coordinated cobalt ions with varied coordination environments.	Benzoates	59-67	complement C2	Homo sapiens	133-136
31339119-10	2019	Co complex 1 incorporating benzoate coligands was demonstrated to effectively catalyze the CO2-copolymerization of cyclohexene oxide (CHO), 4-vinyl-1,2-cyclohexene oxide or cyclopentene oxide, producing the associated CO2-based polycarbonates with >99% carbonate repeated units under optimal conditions.	Benzoates	27-35	complement C2	Homo sapiens	91-94
30338326-1	2018	Cobalt(ii) benzoate trihydrate prepared by the reaction of CoCO3 with benzoic acid (HBz) in boiling water followed by crystallization has been structurally characterized as a chain-like system with the formula unit [Co(Bz)(H2O)2]Bz H2O where the Co(ii) atoms are triply linked by one bridging syn-syn benzoato (Bz) and two aqua ligands; additional benzoate counter ions and solvate water molecules are present in the crystal structure.	Benzoates	11-19	hemoglobin subunit zeta	Homo sapiens	84-87
30476185-4	2019	Haa1 is most sensitive to acetate, followed by lactate, whereas War1 is most sensitive to benzoate, followed by sorbate, reflecting their differential activation during weak acid stresses.	Benzoates	90-98	Haa1p	Saccharomyces cerevisiae S288C	0-4
30476185-4	2019	Haa1 is most sensitive to acetate, followed by lactate, whereas War1 is most sensitive to benzoate, followed by sorbate, reflecting their differential activation during weak acid stresses.	Benzoates	90-98	War1p	Saccharomyces cerevisiae S288C	64-68
30338326-1	2018	Cobalt(ii) benzoate trihydrate prepared by the reaction of CoCO3 with benzoic acid (HBz) in boiling water followed by crystallization has been structurally characterized as a chain-like system with the formula unit [Co(Bz)(H2O)2]Bz H2O where the Co(ii) atoms are triply linked by one bridging syn-syn benzoato (Bz) and two aqua ligands; additional benzoate counter ions and solvate water molecules are present in the crystal structure.	Benzoates	11-19	synemin	Homo sapiens	293-296
30398274-2	2018	The C60 and BDP units are bound to the Al center on the opposite faces of the porphyrin: the BDP derivative through a covalent axial bond using a benzoate spacer and the C60 through a coordination bond via an appended imidazole.	Benzoates	146-154	AT-rich interaction domain 3B	Homo sapiens	12-15
30398274-2	2018	The C60 and BDP units are bound to the Al center on the opposite faces of the porphyrin: the BDP derivative through a covalent axial bond using a benzoate spacer and the C60 through a coordination bond via an appended imidazole.	Benzoates	146-154	AT-rich interaction domain 3B	Homo sapiens	93-96
30338326-1	2018	Cobalt(ii) benzoate trihydrate prepared by the reaction of CoCO3 with benzoic acid (HBz) in boiling water followed by crystallization has been structurally characterized as a chain-like system with the formula unit [Co(Bz)(H2O)2]Bz H2O where the Co(ii) atoms are triply linked by one bridging syn-syn benzoato (Bz) and two aqua ligands; additional benzoate counter ions and solvate water molecules are present in the crystal structure.	Benzoates	11-19	synemin	Homo sapiens	297-300
29414743-4	2018	The results of toluene-TPD followed by TPO and toluene-TPSR match well with the catalytic performances of MOF-Mn1Co1, MOF-Mn1Co2, and MOF-Mn2Co1, and in situ FITR proves that the benzoate route exists over MOF-Mn1Co1.	Benzoates	179-187	thyroid peroxidase	Homo sapiens	39-42
30134657-7	2018	The role of an additional (NMe4)OC(CF3)3 additive in facilitating the overall arylation process is also shown to be linked to a shift in the C-H pre-equilibrium associated with benzoate cyclometalation.	Benzoates	177-185	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	27-31
29633454-3	2018	Environmentally benign twofold C-H/C-H functionalizations were accomplished with weakly coordinating benzoic acids and benzamides, employing electricity as the terminal oxidant and generating H2 as the sole byproduct.	Benzoates	101-114	churchill domain containing 1	Homo sapiens	31-38
28743075-3	2017	Our detailed studies of the kinetics of GH3.5 on a variety of auxin and benzoate substrates provides insight into the acyl preference and reaction mechanism of GH3.5.	Benzoates	72-80	Auxin-responsive GH3 family protein	Arabidopsis thaliana	40-45
28753233-0	2018	Knockout of a P-glycoprotein gene increases susceptibility to abamectin and emamectin benzoate in Spodoptera exigua.	Benzoates	86-94	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
29186795-1	2017	Hydroboration-oxidation of 2alpha,4alpha-dimethanol-1beta,5beta-bicyclo[3.3.0]oct-6-en dibenzoate (1) gave alcohols 2 (symmetric) and 3 (unsymmetric) in ~60% yield, together with the monobenzoate diol 4a (37%), resulting from the reduction of the closer benzoate by the intermediate alkylborane.	Benzoates	89-97	POU class 3 homeobox 1	Homo sapiens	78-83
28743075-3	2017	Our detailed studies of the kinetics of GH3.5 on a variety of auxin and benzoate substrates provides insight into the acyl preference and reaction mechanism of GH3.5.	Benzoates	72-80	Auxin-responsive GH3 family protein	Arabidopsis thaliana	160-165
28743075-4	2017	For example, we found GH3.5 activity on substituted benzoates is not defined by the substitution position as it is for GH3.12/PBS3.	Benzoates	52-61	Auxin-responsive GH3 family protein	Arabidopsis thaliana	22-27
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	Benzoates	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
33371618-3	2017	A few children develop allergy to this additive while, as a competitive inhibitor of D-amino acid oxidase, benzoate can also influence neurotransmission and cognitive functioning.	Benzoates	107-115	D-amino acid oxidase	Homo sapiens	85-105
27641970-8	2017	The thermal stability of GOx increased by 8 C with aniline modification, while it decreased by 0.9 C upon modification with benzoate.	Benzoates	124-132	hydroxyacid oxidase 1	Homo sapiens	25-28
26418869-8	2015	The U12 motif is stabilized by benzoate, oxalates, and glycolate ligands.	Benzoates	31-39	RNA, U12 small nuclear 2, pseudogene	Homo sapiens	4-7
27792148-3	2016	Our calculations show that the LRF-BO enables us not only to detect inductive and resonating effects of conjugating systems, but also to predict pKa values on substitution groups via linear relationships between the Hammett constants and the LRF-BO values for meta- and para-substituted benzoic acids.	Benzoates	287-300	CREB3 regulatory factor	Homo sapiens	31-34
27792148-3	2016	Our calculations show that the LRF-BO enables us not only to detect inductive and resonating effects of conjugating systems, but also to predict pKa values on substitution groups via linear relationships between the Hammett constants and the LRF-BO values for meta- and para-substituted benzoic acids.	Benzoates	287-300	CREB3 regulatory factor	Homo sapiens	242-245
27792148-4	2016	More importantly, the LRF-BO values for the O-H bonds strongly depend on the sites to which the virtual perturbation is applied, implying that the LRF-BO values include essential information about reaction mechanism of the acid-dissociation of substituted benzoic acids.	Benzoates	256-269	CREB3 regulatory factor	Homo sapiens	22-25
27792148-4	2016	More importantly, the LRF-BO values for the O-H bonds strongly depend on the sites to which the virtual perturbation is applied, implying that the LRF-BO values include essential information about reaction mechanism of the acid-dissociation of substituted benzoic acids.	Benzoates	256-269	CREB3 regulatory factor	Homo sapiens	147-150
25434489-10	2015	Although a primary environmental function related to the benzoate degradation pathway of aromatic polymers has been attributed to orthologs of this molecule, our findings support the hypothesis that gp70 is important for pathogenesis and invasion in human sporotrichosis.	Benzoates	57-65	embigin	Homo sapiens	199-203
26301743-4	2015	Experimental pK(a) values of benzoic acids and benzenethiols in [Bmim][NTf2] were reproduced with mean unsigned errors of only 0.3 and 0.5 pK(a) units, respectively, which enables theoretical approaches with a suitable strategy as a powerful tool to handle complicated problems in ILs and to eventually realize the rational design of the IL chemistry.	Benzoates	29-42	nuclear transport factor 2	Homo sapiens	71-75
25423999-5	2014	The carboxylate groups of benzoate anions are coordinated to Co(II) ions in a strong bridging mode, which is the driving force for the anisotropic growth of nanofibers.	Benzoates	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25135626-6	2015	Limits of detection and limits of quantification for benzoate were found to be 0.1 and 0.5 microg mL-1, respectively, and for sorbate 0.08 and 0.3 microg mL-1, respectively.	Benzoates	53-61	L1 cell adhesion molecule	Mus musculus	98-102
25423999-6	2014	When NaOH is added during the synthesis, green irregular shaped platelets are obtained, in which the carboxylate groups of benzoate anions are coordinated to the Co(II) ions in a unidentate fashion.	Benzoates	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
32261448-2	2014	The compound, 4-butylphenyl 4-(6-hydroxyhexyloxy)benzoate (2), showed marked cell-growth inhibition at concentrations higher than 5 muM.	Benzoates	48-57	latexin	Homo sapiens	132-135
24074637-0	2014	Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer disease: a randomized, double-blind, placebo-controlled trial.	Benzoates	0-8	D-amino acid oxidase	Homo sapiens	12-32
24806583-2	2014	The results demonstrate that the reaction is potentially useful as it proceeds under very mild conditions (t = 62  C, PCO = 1 bar) and converts aryl chlorides to far more valuable products (especially ortho-substituted benzoic acids and esters) in high yields.	Benzoates	219-232	PCOS1	Homo sapiens	118-125
24077559-6	2013	Of these, 11 compounds (predominantly substituted benzoates with m- or p-tolyl ligands) proved to be highly effective against the parasite amastigotes at concentrations of 0.5-3.5 muM, while being non-toxic towards the mammalian cells at levels below 25 muM, making them highly promising drug candidates.	Benzoates	50-59	latexin	Homo sapiens	180-183
24077559-6	2013	Of these, 11 compounds (predominantly substituted benzoates with m- or p-tolyl ligands) proved to be highly effective against the parasite amastigotes at concentrations of 0.5-3.5 muM, while being non-toxic towards the mammalian cells at levels below 25 muM, making them highly promising drug candidates.	Benzoates	50-59	latexin	Homo sapiens	254-257
23897214-0	2013	Cu(I), Co(II) and Fe(II) coordination polymers with pyrazine and benzoate as ligands.	Benzoates	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-13
24089054-0	2013	Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.	Benzoates	20-28	D-amino acid oxidase	Homo sapiens	104-124
23237781-1	2013	Human glycine N-acyltransferase (human GLYAT) detoxifies a wide range of endogenous and xenobiotic metabolites, including benzoate and salicylate.	Benzoates	122-130	glycine-N-acyltransferase	Homo sapiens	6-31
23583298-3	2013	In this study, an in vitro nuclear receptor coactivator recruiting assay was developed and used to evaluate the binding activities of parabens, salicylates and benzoates via antagonist competitive binding on the human oestrogen-related receptor gamma (ERRgamma), which is known as both a diagnostic biomarker and a treatment target of breast cancer.	Benzoates	160-169	estrogen related receptor gamma	Homo sapiens	218-261
23418063-5	2013	In the construction of the double-stranded ladder-like structures, the parallel alignment of C C bonds in 2-4 is dictated by the chelating and mu2 -eta(2) :eta(1) bridging modes of the benzoate and toluate ligands.	Benzoates	185-193	adaptor related protein complex 1 subunit mu 2	Homo sapiens	143-146
23237781-1	2013	Human glycine N-acyltransferase (human GLYAT) detoxifies a wide range of endogenous and xenobiotic metabolites, including benzoate and salicylate.	Benzoates	122-130	glycine-N-acyltransferase	Homo sapiens	39-44
22628555-2	2012	Here, we report the crystal structures of benzoate-specific Arabidopsis thaliana AtGH3.12/PBS3 and jasmonic acid-specific AtGH3.11/JAR1.	Benzoates	42-50	Auxin-responsive GH3 family protein	Arabidopsis thaliana	90-94
22981274-12	2013	Increased glutamate efflux at OAT2 could be the main benefit of benzoate treatment in patients with urea cycle defects.	Benzoates	64-72	solute carrier family 22 member 7	Homo sapiens	30-34
23044371-4	2012	We further investigated the SAR (structure-activity relationship) of the benzoate substituent of compound J5, and discovered compounds 8d and 8e as better small molecule inhibitors of SENP1.	Benzoates	73-81	SUMO specific peptidase 1	Homo sapiens	184-189
22762247-9	2012	Finally, benzoate feeding experiments using bzo1 mutants and BZO1 biochemical characterization indicated that the in vivo role of BZO1 is to synthesize the benzoate precursor cinnamoyl CoA rather than to generate benzoyl CoA from benzoate and CoA as previously predicted.	Benzoates	9-17	benzoyloxyglucosinolate 1	Arabidopsis thaliana	130-134
22762247-9	2012	Finally, benzoate feeding experiments using bzo1 mutants and BZO1 biochemical characterization indicated that the in vivo role of BZO1 is to synthesize the benzoate precursor cinnamoyl CoA rather than to generate benzoyl CoA from benzoate and CoA as previously predicted.	Benzoates	156-164	benzoyloxyglucosinolate 1	Arabidopsis thaliana	130-134
22762247-9	2012	Finally, benzoate feeding experiments using bzo1 mutants and BZO1 biochemical characterization indicated that the in vivo role of BZO1 is to synthesize the benzoate precursor cinnamoyl CoA rather than to generate benzoyl CoA from benzoate and CoA as previously predicted.	Benzoates	156-164	benzoyloxyglucosinolate 1	Arabidopsis thaliana	130-134
22579419-2	2012	Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities.	Benzoates	0-8	tyrosinase	Homo sapiens	82-92
22346895-4	2012	The benzoate end of the 3-carb-oxy-benzoate ligand chelates one Pb(II) atom and simultaneously bridges two Pb(II) atoms on either side, forming a chain along the b axis.	Benzoates	4-12	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
22346895-4	2012	The benzoate end of the 3-carb-oxy-benzoate ligand chelates one Pb(II) atom and simultaneously bridges two Pb(II) atoms on either side, forming a chain along the b axis.	Benzoates	4-12	submaxillary gland androgen regulated protein 3B	Homo sapiens	64-70
21050024-1	2010	Aqueous acid dissociation constants of substituted areneseleninic, areneselenenic, arenesulfinic, and benzoic acids are calculated by ab initio (MP2) and DFT (B3LYP) methods in combination with bulk solvation models (IEFPCM, CRSrad) from appropriate thermodynamic cycles.	Benzoates	102-115	tryptase pseudogene 1	Homo sapiens	145-148
21754317-1	2011	In title compound, [Ca(C(7)H(5)O(2))(2)(C(7)H(6)O(2))(H(2)O)](n), the eightfold-coordinated Ca(II) ion is bonded to four carboxyl-ate O atoms from two benzoate ions, an O atom from benzoic acid and a water O atom.	Benzoates	151-159	carbonic anhydrase 2	Homo sapiens	92-98
20866083-0	2010	Iron catalyzed competitive olefin oxidation and ipso-hydroxylation of benzoic acids: further evidence for an Fe(V) O oxidant.	Benzoates	70-83	FEV transcription factor, ETS family member	Homo sapiens	109-114
20886810-9	2010	For compound 3, the existence of the axial magnetic exchange pathway through the syn-syn benzoate bridge may also contribute (in addition to the theta and tau angles) to the observed F interaction in this compound through orbital countercomplementarity, which has been supported by DFT calculations.	Benzoates	89-97	synemin	Homo sapiens	81-84
20886810-9	2010	For compound 3, the existence of the axial magnetic exchange pathway through the syn-syn benzoate bridge may also contribute (in addition to the theta and tau angles) to the observed F interaction in this compound through orbital countercomplementarity, which has been supported by DFT calculations.	Benzoates	89-97	synemin	Homo sapiens	85-88
23766109-8	2010	In addition to a number of motility and chemotaxis genes, the fliA gene product is also necessary for the expression of some genes potentially involved in amino acid utilization or stress responses; however, we were unable to assign specific phenotypes linked to these genes since the fliA mutant used the same range of amino acids as the parental strain, and was as tolerant as the wild type to stress imposed by heat, antibiotics, NaCl, sodium dodecyl sulfate, H2 O2 and benzoate.	Benzoates	473-481	RNA polymerase sigma factor FliA	Pseudomonas putida KT2440	62-66
20521334-5	2010	The ligands used affect the tertiary structure of hDAAO differently: benzoate or trifluoro-D-alanine binding increases the amount of the holoenzyme form in solution and stabilizes the flavoprotein, while CPZ binding favors a protein conformation resembling that of the apoprotein, which is more sensitive to degradation.	Benzoates	69-77	D-amino acid oxidase	Homo sapiens	50-55
20521334-7	2010	Benzoate and CPZ similarly modify the short-term cellular D-serine concentration but affect the cellular concentration of hDAAO differently.	Benzoates	0-8	D-amino acid oxidase	Homo sapiens	122-127
20726777-1	2010	Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1.	Benzoates	91-99	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	152-157
20726777-1	2010	Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1.	Benzoates	91-99	War1p	Saccharomyces cerevisiae S288C	222-226
19597885-3	2009	The mphR encoding the transcriptional activator and mphN encoding the largest subunit of multi-component phenol hydroxylase in the benA mutant were significantly downregulated (about 7- and 70-fold) on the basis of mRNA levels when benzoate was added to the medium.	Benzoates	232-240	mphR	Acinetobacter pittii PHEA-2	4-8
19902937-3	2009	Our previous SAR studies on the k values of betaGAs derived from o-, m-, and p-substituted benzoic acids demonstrated that the diversity and complexity of the k values were controlled by the electronic and/or steric effects of the parent carboxylic acids.	Benzoates	91-104	sarcosine dehydrogenase	Homo sapiens	13-16
19597885-5	2009	These results suggest that catabolite repression of phenol degradation by benzoate in A. calcoaceticus PHEA-2 is mediated by the inhibition of the activator protein MphR.	Benzoates	74-82	mphR	Acinetobacter pittii PHEA-2	165-169
19395484-3	2009	GDH(Geo) was purified from cells grown on benzoate and after the heterologous expression of the benzoate-induced bamM gene.	Benzoates	42-50	glutamate dehydrogenase 1	Homo sapiens	0-3
19395484-3	2009	GDH(Geo) was purified from cells grown on benzoate and after the heterologous expression of the benzoate-induced bamM gene.	Benzoates	96-104	glutamate dehydrogenase 1	Homo sapiens	0-3
26631704-6	2008	In addition, according to the experimentally detected enhancement of the reaction rate due to the presence of a nitro group on the benzoate ligand, our calculations show that the transition state for the hydrogen atom abstraction by molecular oxygen along the pathway for the oxygenation reaction of (IMe)2(p-O2NC6H4CO2)PdH lies lower in energy with respect to the analogous transition state calculated for R=Ph.	Benzoates	131-139	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	320-323
19288492-0	2009	Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.	Benzoates	32-45	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	63-94
19288492-1	2009	We have optimized previously discovered benzoic acids 1, which are active as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer.	Benzoates	40-53	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	91-96
19288492-1	2009	We have optimized previously discovered benzoic acids 1, which are active as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer.	Benzoates	40-53	acid phosphatase 1	Homo sapiens	101-108
18781356-2	2008	Disruption of benM or benA destroyed the ability of PHEA-2 to utilize benzoate.	Benzoates	70-78	benM	Acinetobacter pittii PHEA-2	14-18
18781356-2	2008	Disruption of benM or benA destroyed the ability of PHEA-2 to utilize benzoate.	Benzoates	70-78	benA	Acinetobacter pittii PHEA-2	22-26
18781356-3	2008	The benM mutant was used to construct a genomic library for isolation of the complete gene cluster responsible for benzoate degradation.	Benzoates	115-123	benM	Acinetobacter pittii PHEA-2	4-8
18781356-6	2008	Reverse transcriptase-polymerase chain reaction (RT-PCR) results showed that the benABCDE operon is activated by the BenM protein in the presence of benzoate.	Benzoates	149-157	benM	Acinetobacter pittii PHEA-2	117-121
18781356-8	2008	The activities of catechol 1,2-dioxygenase (C12O) and catechol 2,3-dioxygenase (C23O) showed that PHEA-2 converted benzoate to catechol for further degradation, possibly via an ortho-cleavage pathway.	Benzoates	115-123	catA	Acinetobacter pittii PHEA-2	18-42
19000997-4	2009	DESIGN: Two fetuses with a prenatal diagnosis of UCD (female: citrullinaemia; male: ornithine transcarbamylase deficiency) were loaded with benzoate prenatally via the placenta by infusing their mothers with benzoate.	Benzoates	140-148	ornithine transcarbamylase	Homo sapiens	84-110
19189963-7	2009	We found PBS3 favors 4-substituted benzoates such as 4-aminobenzoate and 4-hydroxybenzoate, with moderate activity on benzoate and no observed activity with 2-substituted benzoates.	Benzoates	35-43	Auxin-responsive GH3 family protein	Arabidopsis thaliana	9-13
19177646-1	2009	Using UHV-STM investigations and density-functional theory calculations we prove the contribution of Cu-adatoms to the stabilization of a new high-density phase of benzoate molecules on a Cu(110) substrate.	Benzoates	164-172	sulfotransferase family 1A member 3	Homo sapiens	10-13
18836712-6	2008	In addition, enzyme activity assays showed that the activities of both catechol 1,2-dioxygenase (C12D; EC1.13.11.1) and catechol 2,3-dioxygenase (C23D; EC1.13.11.2) were detected in benzoate-grown P. putida cells, undoubtedly suggesting the simultaneous expression of both the ortho- and the meta-cleavage pathways in P. putida P8 during the biodegradation of benzoate at high concentration.	Benzoates	182-190	catechol 2,3-dioxygenase	Pseudomonas putida	120-144
18836712-6	2008	In addition, enzyme activity assays showed that the activities of both catechol 1,2-dioxygenase (C12D; EC1.13.11.1) and catechol 2,3-dioxygenase (C23D; EC1.13.11.2) were detected in benzoate-grown P. putida cells, undoubtedly suggesting the simultaneous expression of both the ortho- and the meta-cleavage pathways in P. putida P8 during the biodegradation of benzoate at high concentration.	Benzoates	360-368	catechol 2,3-dioxygenase	Pseudomonas putida	120-144
18384689-10	2008	Lastly, the Western clawed frog (Xenopus tropicalis) PXR was insensitive to vitamins and steroidal compounds and was activated only by benzoates.	Benzoates	135-144	nuclear receptor subfamily 1 group I member 2	Xenopus tropicalis	53-56
18314336-0	2008	Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.	Benzoates	87-100	arachidonate 15-lipoxygenase	Homo sapiens	14-29
18462753-0	2008	Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400.	Benzoates	93-101	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	55-77
18462753-3	2008	The goal of this study is to characterize the biochemical and structural properties of the chromosomally encoded form of this new class of ALDHs from LB400 (ALDH(C)) in order to better understand its role in benzoate degradation.	Benzoates	208-216	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	139-143
18462753-11	2008	This study provides the first integrated biochemical and structural characterization of a box-pathway-encoded ALDH from any organism and offers insight into the catalytic role of ALDH(C) in benzoate degradation.	Benzoates	190-198	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	110-114
18462753-11	2008	This study provides the first integrated biochemical and structural characterization of a box-pathway-encoded ALDH from any organism and offers insight into the catalytic role of ALDH(C) in benzoate degradation.	Benzoates	190-198	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	179-183
18240334-5	2008	Other carboxylate preservatives (propionate, sorbate or benzoate) are too large to traverse the Fps1p pore.	Benzoates	56-64	Fps1p	Saccharomyces cerevisiae S288C	96-101
18446519-12	2008	SLC5A8 can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and gamma-hydroxybutyrate.	Benzoates	107-115	solute carrier family 5 member 8	Homo sapiens	0-6
17385753-2	2007	Some C2 meta-substituted benzoate analogues showed potent activity against both drug-sensitive and drug-resistant tumor cells in which resistance is mediated through either P-gp overexpression or beta-tubulin mutation mechanisms.	Benzoates	25-33	phosphoglycolate phosphatase	Homo sapiens	173-177
18066115-6	2007	Where quantitative structure-activity relationship analysis was insufficient, biochemical assessment demonstrated that the benzoate orsellinic acid blocked downstream caspase-12 activation following ceramide challenge.	Benzoates	123-131	caspase 12	Rattus norvegicus	167-177
17768618-3	2007	Conversely, microbial PCE and cis-DCE dechlorination in cultures with benzoate and acetate resulted in the complete transformation to ethene within 30 days.	Benzoates	70-78	24-dehydrocholesterol reductase	Homo sapiens	34-37
17768618-6	2007	These organisms were identified as responsible for the dechlorination of cis-DCE to ethene in the PCE-dechlorinating consortia, operating together with the Desulfitobacterium as PCE-to-cis-DCE dehalogenating bacterium and with a Syntrophus species as potential hydrogen-producing partner in cultures with benzoate.	Benzoates	305-313	24-dehydrocholesterol reductase	Homo sapiens	77-80
17768618-6	2007	These organisms were identified as responsible for the dechlorination of cis-DCE to ethene in the PCE-dechlorinating consortia, operating together with the Desulfitobacterium as PCE-to-cis-DCE dehalogenating bacterium and with a Syntrophus species as potential hydrogen-producing partner in cultures with benzoate.	Benzoates	305-313	24-dehydrocholesterol reductase	Homo sapiens	189-192
17400261-9	2007	Benzyl benzoates 14a and 15a have methoxyl groups at C-2/C-4 and C-3/C-4 in ring A, respectively; while 30a, in addition to the methoxyl groups at C-2/C-6 of ring A, hold a benzoyloxy moiety at C-3" of ring B.	Benzoates	7-16	complement C2	Bos taurus	53-56
17400261-9	2007	Benzyl benzoates 14a and 15a have methoxyl groups at C-2/C-4 and C-3/C-4 in ring A, respectively; while 30a, in addition to the methoxyl groups at C-2/C-6 of ring A, hold a benzoyloxy moiety at C-3" of ring B.	Benzoates	7-16	complement C4	Bos taurus	57-72
17400261-9	2007	Benzyl benzoates 14a and 15a have methoxyl groups at C-2/C-4 and C-3/C-4 in ring A, respectively; while 30a, in addition to the methoxyl groups at C-2/C-6 of ring A, hold a benzoyloxy moiety at C-3" of ring B.	Benzoates	7-16	complement C2	Bos taurus	147-150
17400261-9	2007	Benzyl benzoates 14a and 15a have methoxyl groups at C-2/C-4 and C-3/C-4 in ring A, respectively; while 30a, in addition to the methoxyl groups at C-2/C-6 of ring A, hold a benzoyloxy moiety at C-3" of ring B.	Benzoates	7-16	complement C3	Bos taurus	65-68
17172314-8	2007	In addition to its similar inhibitory effects on the d-NNA conversion and DAAO activity in kidney homogenates, sodium benzoate completely blocked chiral inversion of d-NNA and led to a smaller stereospecific difference, reflected by a nearly 50% reduction of d-NNA clearance and a 2-fold increase in t(1/2) and area under the curve of d-NNA in benzoate-pretreated rats.	Benzoates	118-126	D-amino-acid oxidase	Rattus norvegicus	74-78
17094945-5	2006	We find that each of these compounds, propionate, 2- and 3-methylbutyrate, benzoate, heptanoate, and 2-ethylhexanoate, inhibits Oat6-mediated uptake of a labeled tracer, estrone sulfate, consistent with their being Oat6 substrates.	Benzoates	75-83	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	128-132
17273798-0	2007	Comparison of benzoate- and dodecaborate-based linkers for attachment of radioiodine to HER2-targeting Affibody ligand.	Benzoates	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-92
17221977-1	2007	The reaction of silylaryl triflates, CsF, and ortho-heteroatom-substituted benzoates affords a general and efficient way to prepare biologically interesting xanthones, thioxanthones, and acridones.	Benzoates	75-84	colony stimulating factor 2	Homo sapiens	37-40
17241437-9	2007	Seven of 11 patients whose impressions were taken at least 3 months after the initiation of cinnamon- and benzoate-free diet also showed reduction in lip size during follow up (P<0.002).	Benzoates	106-114	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	150-153
17094945-5	2006	We find that each of these compounds, propionate, 2- and 3-methylbutyrate, benzoate, heptanoate, and 2-ethylhexanoate, inhibits Oat6-mediated uptake of a labeled tracer, estrone sulfate, consistent with their being Oat6 substrates.	Benzoates	75-83	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	215-219
17088322-5	2006	To address this issue, we determined the crystal structure of human DAO in complex with a competitive inhibitor benzoate, at a resolution of 2.5 Angstrom.	Benzoates	112-120	D-amino acid oxidase	Homo sapiens	68-71
16470664-4	2006	Benzoate dioxygenase (BenA, BenD) and catechol 1,2-dioxygenase (CatA) were induced by benzoate.	Benzoates	86-94	catechol 1,2-dioxygenase	Pseudomonas putida KT2440	38-62
16707699-7	2006	A functional PhoP, PtsP, RelA/SpoT modulon, and adhesion protein LapA were necessary for growth in the presence of urea, and the outer membrane proteins OmlA and FepA and the phosphate transporter PstBACS were indispensable for growth in the presence of benzoate.	Benzoates	254-262	GTP diphosphokinase	Pseudomonas putida KT2440	25-29
16470664-4	2006	Benzoate dioxygenase (BenA, BenD) and catechol 1,2-dioxygenase (CatA) were induced by benzoate.	Benzoates	86-94	catechol 1,2-dioxygenase	Pseudomonas putida KT2440	64-68
15664815-3	2005	The cytosolic isozyme hCA I was strongly activated by acetate, oxalate, pyruvate, l-lactate, and citrate (K(A) around 0.1 microM), whereas formate, malonate, malate, and benzoate were weaker activators (K(A) in the range 0.1-1mM).	Benzoates	170-178	carbonic anhydrase 1	Homo sapiens	22-27
16332855-6	2005	PqorM, which shows similarity to the tandem XylS recognition site of Pm, was cross-activated by the xylS gene product in response to benzoate.	Benzoates	133-141	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	44-48
16332855-6	2005	PqorM, which shows similarity to the tandem XylS recognition site of Pm, was cross-activated by the xylS gene product in response to benzoate.	Benzoates	133-141	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	100-104
15997700-0	2005	A catabolic gene cluster for anaerobic benzoate degradation in methanotrophic microbial Black Sea mats.	Benzoates	39-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	94-97
16248767-4	2005	The in vitro characteristics of the (211)At-benzoate-A33 conjugate ((211)At-A33) were investigated and found to be similar to those of (125)I-benzoate-A33 ((125)I-A33) in different assays.	Benzoates	44-52	glycoprotein A33	Homo sapiens	53-56
16248767-4	2005	The in vitro characteristics of the (211)At-benzoate-A33 conjugate ((211)At-A33) were investigated and found to be similar to those of (125)I-benzoate-A33 ((125)I-A33) in different assays.	Benzoates	44-52	glycoprotein A33	Homo sapiens	76-79
16248767-4	2005	The in vitro characteristics of the (211)At-benzoate-A33 conjugate ((211)At-A33) were investigated and found to be similar to those of (125)I-benzoate-A33 ((125)I-A33) in different assays.	Benzoates	44-52	glycoprotein A33	Homo sapiens	76-79
16248767-4	2005	The in vitro characteristics of the (211)At-benzoate-A33 conjugate ((211)At-A33) were investigated and found to be similar to those of (125)I-benzoate-A33 ((125)I-A33) in different assays.	Benzoates	44-52	glycoprotein A33	Homo sapiens	76-79
15236558-4	2004	The Ca(II) ion binding properties with the benzoate derivatives were also examined using Tb(III) ion as a fluorescence probe.	Benzoates	43-51	carbonic anhydrase 2	Homo sapiens	4-10
15736449-4	2004	MATERIALS AND METHODS: We indirectly astatinated EGF ([211At]-benzoate-EGF) and studied its cellular processing in A-431 carcinoma cells in comparison with data concerning [125I]-benzoate-EGF.	Benzoates	62-70	epidermal growth factor	Homo sapiens	49-52
15480454-4	2004	For oxalate, malonate, benzoate and dibenzoate anions only the beta2 constants could be obtained.	Benzoates	23-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	63-68