PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2654305-5 1989 These results indicate that the systemic absorption of 1% insulin through the eyes can be enhanced at least 7-fold when 1% of the surfactant, saponin, was added to the solution. Saponins 142-149 insulin Homo sapiens 58-65 2654305-7 1989 Most importantly, the blood glucose was reduced concomitantly with the increase of blood insulin when 50 microliters of 1% insulin in 1% saponin solution was instilled in the eyes. Saponins 137-144 insulin Homo sapiens 89-96 2654305-9 1989 In normal animals, 25 microliters of 1% insulin in 1% saponin reduced blood glucose from 102 mg % to 50 mg % in an hour and blood glucose remained low for at least 3 hrs. Saponins 54-61 insulin Homo sapiens 40-47 2654305-10 1989 These results indicate that insulin can be delivered systemically through the eyes, particularly with the surfactant enhancers, such as saponin. Saponins 136-143 insulin Homo sapiens 28-35 2928797-4 1989 In saponin-permeabilized platelets, added histamine reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen. Saponins 3-10 histidine decarboxylase Homo sapiens 87-90 2493244-2 1989 Indirect immunofluorescence staining with anti-CD4 antibodies revealed newly internalized CD4 in ganglioside-treated cells after membrane permeabilization with 0.1% saponin. Saponins 165-172 CD4 molecule Homo sapiens 47-50 2493244-2 1989 Indirect immunofluorescence staining with anti-CD4 antibodies revealed newly internalized CD4 in ganglioside-treated cells after membrane permeabilization with 0.1% saponin. Saponins 165-172 CD4 molecule Homo sapiens 90-93 2912451-3 1989 In saponin-treated skinned myometrial cells from pregnant rats, 100 nM-TPA enhanced the contraction induced by 0.3 microM-Ca2+, but reduced that induced by 1 microM-Ca2+. Saponins 3-10 plasminogen activator, tissue type Rattus norvegicus 71-74 2537621-5 1989 The efflux of several secretory proteins was studied at various saponin concentrations; a 2-fold higher saponin concentration was required to release transferrin compared with that required to release albumin and orosomucoid. Saponins 104-111 transferrin Homo sapiens 150-161 2473929-0 1989 Zhi-mu saponin inhibits alpha-fetoprotein gene expression in developing rat liver. Saponins 7-14 alpha-fetoprotein Rattus norvegicus 24-41 2473929-2 1989 A saponin isolated from the Chinese herb zhi-mu (Anemarrhena asphodeloides Bunge) modifies alpha-fetoprotein production when injected into newborn rats. Saponins 2-9 alpha-fetoprotein Rattus norvegicus 91-108 3182080-2 1988 In the studies described in this paper, we investigated the ability of the purified M-2 molecule to elicit a protective immune response in conjunction with Freund incomplete and complete adjuvants, saponin, and Corynebacterium parvum. Saponins 198-205 cholinergic receptor, muscarinic 2, cardiac Mus musculus 84-87 3063257-0 1988 Action of guanosine 5"-[beta-thio]diphosphate on thrombin-induced activation and Ca2+ mobilization in saponin-permeabilized and intact human platelets. Saponins 102-109 coagulation factor II, thrombin Homo sapiens 49-57 3128172-0 1988 Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: evidence for involvement of GTP-binding protein in phospholipase A2 activation. Saponins 65-72 phospholipase A2 Oryctolagus cuniculus 151-167 3120720-1 1987 Human platelets labeled with [3H]arachidonic acid and permeabilized with saponin produced [3H]1,2-diacylglycerol (DG) by phospholipase C and released [3H]arachidonate by phospholipase A2, when activated with thrombin. Saponins 73-80 phospholipase A2 group IB Homo sapiens 170-186 3257448-2 1988 In saponin-permeabilized rat hepatocytes, neomycin via its ability to bind Ins (1,4,5)P3 abolished the release of Ca2+ induced by added Ins (1,4,5)P3. Saponins 3-10 carbonic anhydrase 2 Rattus norvegicus 114-117 2829859-4 1988 Thrombin also stimulated 45Ca2+ uptake into saponin-treated platelets. Saponins 44-51 coagulation factor II, thrombin Homo sapiens 0-8 2972328-8 1988 ATPase activities were operationally defined and measured in saponin lysates of these rbcs. Saponins 61-68 dynein axonemal heavy chain 8 Homo sapiens 0-6 3120720-1 1987 Human platelets labeled with [3H]arachidonic acid and permeabilized with saponin produced [3H]1,2-diacylglycerol (DG) by phospholipase C and released [3H]arachidonate by phospholipase A2, when activated with thrombin. Saponins 73-80 coagulation factor II, thrombin Homo sapiens 208-216 3023367-8 1986 Guanosine 5"-O-(2-thiodiphosphate) (GDP beta S), which inhibits G protein function, inhibited the ability of thrombin to cause IP3 and diacylglycerol formation, granule secretion, and Ca2+ release from the dense tubular system in saponin-treated platelets. Saponins 230-237 coagulation factor II, thrombin Homo sapiens 109-117 2826256-3 1987 We have now tested the specificity of various nucleotides in regulating PIC activity in the absence or presence of the hormone cholecystokinin (CCK-8) in saponin-permeabilized [3H]inositol-labelled Flow 9000 cells. Saponins 154-161 phospholipase C beta 1 Homo sapiens 72-75 3667697-9 1987 Immunocytochemical study revealed that myosin was present in the saponin-extracted cytoskeleton after activation and that myosin was localized on the filamentous network. Saponins 65-72 myosin heavy chain 14 Homo sapiens 39-45 3662529-0 1987 Effect of guanosine triphosphate on the release of Ca2+ from intracellular store sites of saponin-treated human peripheral lymphocytes. Saponins 90-97 carbonic anhydrase 2 Homo sapiens 51-54 3662529-4 1987 On the other hand, Ca2+ uptake in the presence of oxalate by saponin-treated lymphocytes was stimulated by GTP and this stimulation was abolished when polyethylene glycol was concomitantly present. Saponins 61-68 carbonic anhydrase 2 Homo sapiens 19-22 3662529-6 1987 These results indicate that GTP has an inherent activity to release Ca2+ as well as to stimulate the uptake of Ca2+ in nonmitochondrial intracellular store sites of saponin-treated lymphocytes. Saponins 165-172 carbonic anhydrase 2 Homo sapiens 111-114 3107563-1 1987 Guanosine 5"-O-thiotriphosphate (GTP gamma S) and thrombin stimulate the activity of phospholipase C in platelets that have been permeabilized with saponin and whose inositol phospholipids have been prelabeled with [3H]inositol. Saponins 148-155 coagulation factor II, thrombin Homo sapiens 50-58 3104349-5 1987 The staining pattern of u-PA and PAI-1 resisted treatment with 0.2% saponin followed by mechanical removal of cells, a method previously reported to isolate focal contact membranes of fibroblasts. Saponins 68-75 plasminogen activator, urokinase Homo sapiens 24-28 3104349-5 1987 The staining pattern of u-PA and PAI-1 resisted treatment with 0.2% saponin followed by mechanical removal of cells, a method previously reported to isolate focal contact membranes of fibroblasts. Saponins 68-75 serpin family E member 1 Homo sapiens 33-38 3104349-6 1987 We further demonstrated the deposition of u-PA to the contact areas of cells obtained by saponin treatment by zymography, and that of PAI-1 by metabolic labeling, reverse zymography, immunoblotting, and immunoprecipitation. Saponins 89-96 plasminogen activator, urokinase Homo sapiens 42-46 3112131-0 1987 Guanine nucleotides stimulate arachidonic acid release by phospholipase A2 in saponin-permeabilized human platelets. Saponins 78-85 phospholipase A2 group IB Homo sapiens 58-74 3112131-6 1987 These data indicate that the release of arachidonic acid by phospholipase A2 in saponin-treated platelets may be linked to a GTP-binding protein. Saponins 80-87 phospholipase A2 group IB Homo sapiens 60-76 3023367-5 1986 In platelets permeabilized with saponin, nonhydrolyzable GTP analogs reproduced the effects of thrombin by causing diacylglycerol formation, Ca2+ release from the dense tubular system and serotonin secretion. Saponins 32-39 coagulation factor II, thrombin Homo sapiens 95-103 3497866-2 1987 The in vivo lymphocyte proliferation in mice fed antigen + saponin (AG + SAP) was significantly greater than that in mice fed antigen (AG) alone. Saponins 59-66 SH2 domain containing 1A Mus musculus 73-76 3497866-7 1987 Our present data indicate that the immunocompetence in animals fed AG + SAP was indeed evoked by saponins. Saponins 97-105 SH2 domain containing 1A Mus musculus 72-75 3023367-11 1986 Thrombin-induced diacylglycerol formation and 45Ca release were also inhibited when the saponin-treated platelets were preincubated with pertussis toxin, an event that was associated with the ADP-ribosylation of a protein with Mr = 41.7 kDa. Saponins 88-95 coagulation factor II, thrombin Homo sapiens 0-8 3733740-10 1986 In Golgi membranes permeabilized by treatment with 0.5% saponin, mannosidase II could readily be cleaved to the 110,000-dalton form by digestion with chymotrypsin under conditions similar to those which result in a proteolytic inactivation of galactosyltransferase, a lumenal Golgi membrane marker. Saponins 56-63 glycoprotein alpha-galactosyltransferase 1 Rattus norvegicus 243-264 3486313-4 1986 We therefore investigated the effect of angiotensin II-amide and IP3 on intracellular Ca2 stores in saponin-treated cells and homogenate from rat kidney cortex. Saponins 100-107 carbonic anhydrase 2 Rattus norvegicus 86-89 3955077-1 1986 We have recently reported that human neutrophils can be permeabilized with the cholesterol complexing agent saponin and that these cells can be induced to secrete the granule enzyme lysozyme in response to micromolar levels of free calcium. Saponins 108-115 lysozyme Homo sapiens 182-190 3958056-1 1986 Acetylcholine receptor (AChR) clusters of cultured rat myotubes, isolated by extraction with saponin (Bloch, R. J., 1984, J. Saponins 93-100 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 0-22 2939827-7 1986 Saponin-permeabilized platelets show identical platelet responses (shape change, aggregation and release of 5-hydroxy[14C]tryptamine) to both collagen (5 micrograms/ml) and thrombin (0.1 unit/ml) as obtained with intact cells, indicating that there is minimal disturbance to the surface membrane receptor topography for these two agonists. Saponins 0-7 coagulation factor II, thrombin Homo sapiens 173-181 3518389-2 1986 With this procedure, we compared the effect of various fixatives, with or without saponin permeabilization, on the immunoreactivity of a secretory product (prolactin) and membrane proteins in cultured prolactin cells. Saponins 82-89 prolactin Homo sapiens 156-165 2939827-8 1986 Ins(1,4,5)P3 (1-10 microM) added to saponin-treated platelets (but not to intact platelets) induced dose-related shape change, aggregation and release of 5-hydroxy[14C]tryptamine which at maximal doses was comparable with responses obtained with thrombin or collagen. Saponins 36-43 coagulation factor II, thrombin Homo sapiens 246-254 4041533-2 1985 Both nonpermeabilized and permeabilized (with Tween 20, saponin, or cold acetone) spermatozoa showed fluorescence following treatment with antirabbit SBP (anti-rSBP) and subsequently with rabbit antisheep immunoglobulin G-fluorescein isothiocyanate. Saponins 56-63 sex hormone-binding globulin Oryctolagus cuniculus 150-153 3599553-1 1986 The effects of Ca2+ and calmodulin on contraction of saponin-treated (chemically skinned) uterine smooth muscle fibers of pregnant rats were examined. Saponins 53-60 calmodulin 1 Rattus norvegicus 24-34 3599553-6 1986 The amount of calmodulin, which eluted out of uterine muscle cells during saponin treatment, was large in the early and middle stages of pregnancy. Saponins 74-81 calmodulin 1 Rattus norvegicus 14-24 4041465-4 1985 The release of glyceraldehyde-3-phosphate dehydrogenase from fresh rat erythrocytes immediately following saponin lysis was also determined using the rapid filtration technique recently described. Saponins 106-113 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 15-55 2430128-1 1986 The particle transport in axons permeabilized with saponin was blocked by three actin-related proteins, 88 K protein/actin complex, actinogelin, and cofilin. Saponins 51-58 cofilin 1 Homo sapiens 149-156 4041533-2 1985 Both nonpermeabilized and permeabilized (with Tween 20, saponin, or cold acetone) spermatozoa showed fluorescence following treatment with antirabbit SBP (anti-rSBP) and subsequently with rabbit antisheep immunoglobulin G-fluorescein isothiocyanate. Saponins 56-63 spermine binding protein Rattus norvegicus 160-164 3928634-3 1985 When the S. aureus cells bearing the immunoadsorbed material were treated with 0.5% saponin, extracts containing the precursor form of cathepsin D were obtained. Saponins 84-91 cathepsin D Homo sapiens 135-146 3928634-6 1985 The extraction of this cathepsin D precursor was independent of mannose 6-phosphate and was complete after a brief exposure to saponin. Saponins 127-134 cathepsin D Homo sapiens 23-34 6940463-3 1981 In addition, melittin as well as another surfactant, saponin, were potent adjuvants for IgE formation in mice when mixed with ovalbumin (Ov). Saponins 53-60 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 126-135 3968435-0 1985 Micromolar concentrations of free calcium provoke secretion of lysozyme from human neutrophils permeabilized with saponin. Saponins 114-121 lysozyme Homo sapiens 63-71 2866887-0 1985 Roles of Ca2+ on the inositol 1,4,5-trisphosphate-induced release of Ca2+ from saponin-permeabilized single cells of the porcine coronary artery. Saponins 79-86 carbonic anhydrase 2 Homo sapiens 9-12 2866887-0 1985 Roles of Ca2+ on the inositol 1,4,5-trisphosphate-induced release of Ca2+ from saponin-permeabilized single cells of the porcine coronary artery. Saponins 79-86 carbonic anhydrase 2 Homo sapiens 69-72 6489348-3 1984 The concentration of saponin for 50% inhibition (IC50) of major saponin-sensitive Ca2+ uptake was 11 micrograms/ml, and this uptake was enhanced by calmodulin. Saponins 21-28 calmodulin-2 Canis lupus familiaris 148-158 6489348-3 1984 The concentration of saponin for 50% inhibition (IC50) of major saponin-sensitive Ca2+ uptake was 11 micrograms/ml, and this uptake was enhanced by calmodulin. Saponins 64-71 calmodulin-2 Canis lupus familiaris 148-158 6147347-9 1984 Ca2+ accumulated in vesicles via either the Ca2+ pump or Na+-Ca2+ exchanger is rapidly (in less than 1 min) released by 0.1% saponin (w/v), although a minor component (8-10%) of Ca2+ pump activity is resistant to saponin addition. Saponins 125-132 solute carrier family 8 member A1 Homo sapiens 57-75 6147347-9 1984 Ca2+ accumulated in vesicles via either the Ca2+ pump or Na+-Ca2+ exchanger is rapidly (in less than 1 min) released by 0.1% saponin (w/v), although a minor component (8-10%) of Ca2+ pump activity is resistant to saponin addition. Saponins 213-220 solute carrier family 8 member A1 Homo sapiens 57-75 6381511-3 1984 The domain structure evident in intact cells was maintained in AChR clusters after isolation using saponin. Saponins 99-106 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 63-67 6371135-0 1984 Ultrastructural indirect immunolocalization of transferrin in cultured rat hepatocytes permeabilized with saponin. Saponins 106-113 transferrin Rattus norvegicus 47-58 6371135-1 1984 Transferrin was localized in 48-hr cultured adult rat hepatocytes by indirect immunoperoxidase following paraformaldehyde--glutaraldehyde fixation and the use of saponin as a membrane permeabilizing agent. Saponins 162-169 transferrin Rattus norvegicus 0-11 6229546-6 1984 The presence of fibrinogen, beta TG, and PF4 in corresponding large intracellular vacuoles and along the platelet plasma membrane after thrombin stimulation was demonstrated by immunocytochemical techniques in saponin-permeabilized and nonpermeabilized platelets. Saponins 210-217 fibrinogen beta chain Homo sapiens 16-26 6229546-6 1984 The presence of fibrinogen, beta TG, and PF4 in corresponding large intracellular vacuoles and along the platelet plasma membrane after thrombin stimulation was demonstrated by immunocytochemical techniques in saponin-permeabilized and nonpermeabilized platelets. Saponins 210-217 pro-platelet basic protein Homo sapiens 28-35 6229546-6 1984 The presence of fibrinogen, beta TG, and PF4 in corresponding large intracellular vacuoles and along the platelet plasma membrane after thrombin stimulation was demonstrated by immunocytochemical techniques in saponin-permeabilized and nonpermeabilized platelets. Saponins 210-217 platelet factor 4 Homo sapiens 41-44 6229546-6 1984 The presence of fibrinogen, beta TG, and PF4 in corresponding large intracellular vacuoles and along the platelet plasma membrane after thrombin stimulation was demonstrated by immunocytochemical techniques in saponin-permeabilized and nonpermeabilized platelets. Saponins 210-217 coagulation factor II, thrombin Homo sapiens 136-144 6689959-6 1984 In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+. Saponins 7-14 carbonic anhydrase 2 Oryctolagus cuniculus 57-60 6689959-6 1984 In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+. Saponins 7-14 carbonic anhydrase 2 Oryctolagus cuniculus 94-97 6689959-6 1984 In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+. Saponins 7-14 carbonic anhydrase 2 Oryctolagus cuniculus 94-97 6689959-6 1984 In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+. Saponins 7-14 carbonic anhydrase 2 Oryctolagus cuniculus 94-97 7026668-4 1981 However, when the cell surface antigen was blocked in advance with specific unlabeled antibodies and direct immunocytochemistry performed in the presence of saponin, intracellular alkaline phosphatase antigen was observed in the perinuclear space, endoplasmic reticulum, and Golgi apparatus. Saponins 157-164 CD53 molecule Homo sapiens 18-38 2987242-0 1985 Thrombin induces serotonin secretion and aggregation independently of inositol phospholipids hydrolysis and protein phosphorylation in human platelets permeabilized with saponin. Saponins 170-177 coagulation factor II, thrombin Homo sapiens 0-8 6092900-7 1984 Furthermore, in addition to spontaneous dissociation from ASPG-R following return to the cell surface, studies conducted in saponin-permeabilized monolayers support the return of free intracellular 125I-Gal-cytochrome c to the cell surface during exocytosis. Saponins 124-131 cytochrome c, somatic Homo sapiens 207-219 6333869-0 1984 Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate. Saponins 91-98 carbonic anhydrase 2 Homo sapiens 11-14 6333869-3 1984 In the presence of 10 mM-NaN3, the Ca2+ accumulated in the presence of oxalate was seen in the endoplasmic reticulum of saponin-treated macrophages by electron microscopy, indicating that the site of Ca2+ released by inositol 1,4,5-trisphosphate may be endoplasmic reticulum-like membranes. Saponins 120-127 carbonic anhydrase 2 Homo sapiens 35-38 6333869-3 1984 In the presence of 10 mM-NaN3, the Ca2+ accumulated in the presence of oxalate was seen in the endoplasmic reticulum of saponin-treated macrophages by electron microscopy, indicating that the site of Ca2+ released by inositol 1,4,5-trisphosphate may be endoplasmic reticulum-like membranes. Saponins 120-127 carbonic anhydrase 2 Homo sapiens 200-203 6201493-8 1984 When a saponin-permeabilized, agarose-embedded plasma membrane (PM) fraction was incubated with affinity-purified anti-LAP, 85% of the protein A-gold particles associated with the three recognizable PM domains were present in the BC. Saponins 7-14 leucine aminopeptidase 3 Rattus norvegicus 119-122 6727582-6 1984 However, A15 /27 (but not A9/63 or B20 ) reacted with saponin-permeabilized PLC/PRF/5 and Chang cells and also with rabbit LSP. Saponins 54-61 immunoglobulin kappa variable 1-32 (pseudogene) Homo sapiens 9-12 6727582-6 1984 However, A15 /27 (but not A9/63 or B20 ) reacted with saponin-permeabilized PLC/PRF/5 and Chang cells and also with rabbit LSP. Saponins 54-61 heparan sulfate proteoglycan 2 Homo sapiens 76-79 6366416-0 1984 Effect of trifluoperazine and calmodulin on catecholamine secretion by saponin-skinned cultured chromaffin cells. Saponins 71-78 calmodulin 1 Homo sapiens 30-40 6141172-5 1984 The conjugates enter saponin-permeabilized cells and, as judged by the inhibition of [125I] alpha BTX binding, they label the entire intracellular AChR pool. Saponins 21-28 cholinergic receptor nicotinic delta subunit Gallus gallus 147-151 6865902-0 1983 Effect of calmodulin and calmodulin antagonists on the Ca2+ uptake by the intracellular Ca2+-accumulating system of guinea pig peritoneal macrophages treated with saponin. Saponins 163-170 calmodulin-3 Cavia porcellus 25-35 7066603-1 1982 1 Effects of chlorpromazine on the contraction evoked in intact muscles, and of chlorpromazine or calmodulin on the contraction evoked in the saponin-treated skinned muscles of the guinea-pig mesenteric artery were investigated. Saponins 143-150 calmodulin-3 Cavia porcellus 99-109 6174528-11 1982 LPO-catalyzed radioiodinations were performed on normal and saponin-treated vesicles and on vesicles from which the Mr (relative molecular mass) 43,000 protein had been removed by alkaline extraction. Saponins 60-67 lactoperoxidase Homo sapiens 0-3 6940463-3 1981 In addition, melittin as well as another surfactant, saponin, were potent adjuvants for IgE formation in mice when mixed with ovalbumin (Ov). Saponins 53-60 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 137-139 6940463-4 1981 Titres of 1280 and 2560 to ovalbumin were produced in CBA mice after two injections of melittin and Ov or saponin and Ov. Saponins 106-113 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 27-36 146397-5 1976 Thiocyanate inhibited saponin-stimulated Mg-ATPase, Ki = 1.85 X 10(-2)M. The probable mechanisms of action of the above anions on Mg-ATPase and possible relation to passive permeability of Na+ and K+ ions are discussed. Saponins 22-29 dynein axonemal heavy chain 8 Homo sapiens 44-50 7006375-7 1980 After Ohtsuki"s hypotonic fixative followed by saponin permeabilization, PRL is visualized within the totality of RER cisternae, including the perinuclear cisternae and the peripheral saccules on the cis-Golgi face. Saponins 47-54 prolactin Rattus norvegicus 73-76 394767-0 1979 Enhancement and suppression in production of IgM-antibody in mice treated with purified saponins. Saponins 88-96 immunoglobulin heavy constant mu Mus musculus 45-48 146397-5 1976 Thiocyanate inhibited saponin-stimulated Mg-ATPase, Ki = 1.85 X 10(-2)M. The probable mechanisms of action of the above anions on Mg-ATPase and possible relation to passive permeability of Na+ and K+ ions are discussed. Saponins 22-29 dynein axonemal heavy chain 8 Homo sapiens 133-139 4667544-0 1972 [Effectiveness of anti-foot-and-mouth disease GOA-formol vaccine with saponin]. Saponins 70-77 tripartite motif containing 47 Homo sapiens 46-49 240521-3 1975 In the recommended assay saponin is used for lysis of erythrocytes when testing adenosine deaminase activity in red blood cells. Saponins 25-32 adenosine deaminase Homo sapiens 80-99 33910079-4 2021 PEGylated nanoparticle albumin-bound (PNAB) was used to promote prolonged bioactivity of steroidal ginsenoside saponins, PNAB-Rg6 and PNAB-Rgx365. Saponins 111-119 albumin Homo sapiens 23-30 32608254-1 2021 This study aimed to evaluate the effect Cycloastragenol (CAG), a triterpenoid saponin isolated from the Radix astragali, on Abeta-induced BBB damage. Saponins 78-85 histocompatibility 2, class II antigen A, beta 1 Mus musculus 124-129 33781874-7 2021 We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis. Saponins 124-132 NFE2 like bZIP transcription factor 2 Homo sapiens 277-320 33781874-7 2021 We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis. Saponins 124-132 NFE2 like bZIP transcription factor 2 Homo sapiens 322-326 34044827-0 2021 The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway. Saponins 15-22 AKT serine/threonine kinase 1 Homo sapiens 108-111 34044827-0 2021 The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway. Saponins 15-22 mechanistic target of rapamycin kinase Homo sapiens 112-116 34052350-0 2021 Anemarrhena Saponins Attenuate Insulin Resistance in Rats with High-Fat Diet-Induced Obesity via the IRS-1/PI3K/AKT Pathway. Saponins 12-20 insulin receptor substrate 1 Rattus norvegicus 101-106 34052350-0 2021 Anemarrhena Saponins Attenuate Insulin Resistance in Rats with High-Fat Diet-Induced Obesity via the IRS-1/PI3K/AKT Pathway. Saponins 12-20 AKT serine/threonine kinase 1 Rattus norvegicus 112-115 34052350-9 2021 Further, we conducted in vivo and in vitro experiments, and Western-blot analysis to study the effects of anemarrhena saponins on the IRS-1/PI3K/AKT pathway. Saponins 118-126 insulin receptor substrate 1 Rattus norvegicus 134-139 34052350-12 2021 Moreover, anemarrhena saponins up-regulated the phosphorylation levels of IRS-1, PI3K and AKT, promoted insulin signal transduction, and reduced liver injury induced by insulin resistance. Saponins 22-30 insulin receptor substrate 1 Rattus norvegicus 74-79 34052350-12 2021 Moreover, anemarrhena saponins up-regulated the phosphorylation levels of IRS-1, PI3K and AKT, promoted insulin signal transduction, and reduced liver injury induced by insulin resistance. Saponins 22-30 AKT serine/threonine kinase 1 Rattus norvegicus 90-93 34052350-13 2021 CONCLUSIONS: These findings suggest that anemarrhena saponins could promote insulin signal transduction through the IRS-1/PI3K/AKT pathway, thereby reducing the damage caused by insulin resistance. Saponins 53-61 insulin receptor substrate 1 Rattus norvegicus 116-121 34052350-13 2021 CONCLUSIONS: These findings suggest that anemarrhena saponins could promote insulin signal transduction through the IRS-1/PI3K/AKT pathway, thereby reducing the damage caused by insulin resistance. Saponins 53-61 AKT serine/threonine kinase 1 Rattus norvegicus 127-130 34044075-0 2021 Astragalus saponins improves stroke by promoting the proliferation of neural stem cells through phosphorylation of Akt. Saponins 11-19 thymoma viral proto-oncogene 1 Mus musculus 115-118 34044075-13 2021 CONCLUSION: The present study elucidated that Astragalus saponins pretreatment could provide a protective effect on experimental stroke mainly by enhancing proliferation of NSCs through targeting Akt. Saponins 57-65 thymoma viral proto-oncogene 1 Mus musculus 196-199 33753260-4 2021 We found that the isolated saponins (14-17) bind to the substrate-binding pocket of SARS-CoV-2 Mpro with docking energy scores of -7.13, -7.29, -7.47, and -7.54 kcal.mol-1, respectively, along with binding abilities equivalent to an already claimed N3 protease inhibitor (-7.51 kcal.mol-1). Saponins 27-35 NEWENTRY Severe acute respiratory syndrome-related coronavirus 95-99 33578123-5 2021 The relative standard error of prediction (RSEP) values of five saponins including notoginsenoside R1, ginsenoside Rg1, Re, Rb1, and Rd were 3.240%, 5.468%, 5.303%, 5.043%, and 3.745%, respectively. Saponins 64-72 protein phosphatase 1 regulatory subunit 3A Homo sapiens 115-118 33578123-5 2021 The relative standard error of prediction (RSEP) values of five saponins including notoginsenoside R1, ginsenoside Rg1, Re, Rb1, and Rd were 3.240%, 5.468%, 5.303%, 5.043%, and 3.745%, respectively. Saponins 64-72 RB transcriptional corepressor 1 Homo sapiens 124-127 19873462-7 1946 Rhodopsin was an inevitable contaminant in most methods of extraction, but could be reduced to about 10 per cent of the absorption due to iodopsin by extraction of unhardened retinas with 4 per cent Merck"s saponin in (3/4) saturated magnesium sulfate for about 1 hour. Saponins 207-214 rhodopsin Homo sapiens 0-9 33845383-4 2021 In order to discover proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, fourteen new triterpenoid saponins named gypenoside LXXXVIII-CI (1-14) along with six known compounds (15-20) were isolated from G. pentaphyllum. Saponins 113-121 proprotein convertase subtilisin/kexin type 9 Homo sapiens 68-73 34041517-3 2021 Using a series of platelet function assays, we found that G-Rb2 and G-Rd2, among the ten PNF saponin monomers, significantly inhibited human platelet aggregation and activation induced by adenosine diphosphate (ADP) in vitro. Saponins 93-100 RB transcriptional corepressor like 2 Homo sapiens 60-63 34041517-3 2021 Using a series of platelet function assays, we found that G-Rb2 and G-Rd2, among the ten PNF saponin monomers, significantly inhibited human platelet aggregation and activation induced by adenosine diphosphate (ADP) in vitro. Saponins 93-100 peripherin 2 Homo sapiens 70-73 34038799-6 2021 RESULTS: The ultrasonic extraction parameters of saponins fraction, including ethanol concentration 30%, extraction time 55 min, ratio of solvent to material 35:1 ml/g and extraction temperature 46 C, were screened by response surface method with the extracting rate 5.49%, and thirty compositions were detected with LC-MSn method. Saponins 49-57 moesin Mus musculus 320-323 34038799-7 2021 Moreover, saponins fraction can play a stronger anti-inflammatory effect by reducing the phagocytic activity and pulmonary edema, and protection of morphology of RAW 264.7 cells and lung tissues, and decreasing the content of NO and TNF-alpha. Saponins 10-18 tumor necrosis factor Mus musculus 233-242 33999391-9 2021 The K and ERb of tea saponin from tea seeds were 0.12 and 94.50% with 7.5 mM LiBr at pH 8.0 and 25 C, respectively. Saponins 21-28 estrogen receptor 2 Homo sapiens 10-13 33069631-0 2021 Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway. Saponins 0-8 AKT serine/threonine kinase 1 Rattus norvegicus 103-106 33069631-0 2021 Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway. Saponins 0-8 forkhead box O1 Rattus norvegicus 107-112 33069631-7 2021 First, saponins increased the mRNA and protein levels of IRS-2 but decreased the serine 731 phosphorylation level of IRS-2. Saponins 7-15 insulin receptor substrate 2 Rattus norvegicus 57-62 33069631-7 2021 First, saponins increased the mRNA and protein levels of IRS-2 but decreased the serine 731 phosphorylation level of IRS-2. Saponins 7-15 insulin receptor substrate 2 Rattus norvegicus 117-122 33069631-8 2021 Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. Saponins 10-18 AKT serine/threonine kinase 1 Rattus norvegicus 52-55 33069631-8 2021 Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. Saponins 10-18 forkhead box O1 Rattus norvegicus 99-104 33069631-9 2021 Furthermore, saponins increased the protein level of the downstream molecule and insulin initiating factor PDX-1, which was also reversed by ly294002. Saponins 13-21 pancreatic and duodenal homeobox 1 Rattus norvegicus 107-112 33069631-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 AKT serine/threonine kinase 1 Rattus norvegicus 24-27 33069631-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 pancreatic and duodenal homeobox 1 Rattus norvegicus 32-37 33069631-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 forkhead box O1 Rattus norvegicus 57-62 33069631-13 2021 In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway. Saponins 130-138 AKT serine/threonine kinase 1 Rattus norvegicus 183-186 33069631-13 2021 In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway. Saponins 130-138 forkhead box O1 Rattus norvegicus 187-192 33915505-11 2021 Molecular docking revealed Fructus saponins I"s high affinity with FIS1, MFN1, MFN2, and OPA1. Saponins 35-43 fission, mitochondrial 1 Homo sapiens 67-71 33915505-11 2021 Molecular docking revealed Fructus saponins I"s high affinity with FIS1, MFN1, MFN2, and OPA1. Saponins 35-43 mitofusin 1 Homo sapiens 73-77 33915505-11 2021 Molecular docking revealed Fructus saponins I"s high affinity with FIS1, MFN1, MFN2, and OPA1. Saponins 35-43 OPA1 mitochondrial dynamin like GTPase Homo sapiens 89-93 33865981-3 2021 Ginsenoside Rg1 (Rg1), notoginsenoside R1 (NgR1), and notoginsenoside R2 (NgR2) are three major PPT-type saponins in P. notoginseng and possess potential cardiovascular protection activities. Saponins 105-113 Ngr1p Saccharomyces cerevisiae S288C 43-47 34025139-10 2021 Conclusion: RGE and its saponins inhibit IL-1beta secretion in response to UV exposure in both keratinocytes and macrophages. Saponins 24-32 interleukin 1 alpha Homo sapiens 41-49 33865981-6 2021 Using one of these UGTs, PgUGT94Q13, and the previously identified PgUGT71A53 and PgUGT71A54, the biosynthetic pathway to produce saponins NgR1 and NgR2 from PPT could be available. Saponins 130-138 Ngr1p Saccharomyces cerevisiae S288C 139-143 33884100-0 2021 IRS-2/Akt/GSK-3beta/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity. Saponins 85-92 insulin receptor substrate 2 Mus musculus 0-5 33884100-0 2021 IRS-2/Akt/GSK-3beta/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity. Saponins 85-92 thymoma viral proto-oncogene 1 Mus musculus 6-9 33884100-0 2021 IRS-2/Akt/GSK-3beta/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity. Saponins 85-92 glycogen synthase kinase 3 alpha Mus musculus 10-19 33884100-0 2021 IRS-2/Akt/GSK-3beta/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity. Saponins 85-92 nuclear factor, erythroid derived 2, like 2 Mus musculus 20-24 33446655-4 2021 In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease. Saponins 35-42 angiotensin converting enzyme 2 Homo sapiens 108-113 33321190-0 2021 Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H2O2-induced apoptosis by modulating Ezh2 phosphorylation. Saponins 13-21 enhancer of zeste 2 polycomb repressive complex 2 subunit Rattus norvegicus 113-117 33656663-11 2021 Panax notoginseng saponins (PNS) ameliorated hepatic steatosis and fibrosis, and gut-liver axis-mediated pathogenesis of NAFLD is proposed to occur in a TLR4-dependent manner. Saponins 18-26 toll-like receptor 4 Mus musculus 153-157 33485994-6 2021 BALB/c mice immunization with a DNA plasmid and recombinant protein plus saponin induced development of specific Th1-type immunity, characterized by high levels of IFN-gamma, IL-12, GM-CSF, both T cell subtypes and antileishmanial IgG2a isotype antibodies, before and after infection. Saponins 73-80 interferon gamma Mus musculus 164-173 33485994-6 2021 BALB/c mice immunization with a DNA plasmid and recombinant protein plus saponin induced development of specific Th1-type immunity, characterized by high levels of IFN-gamma, IL-12, GM-CSF, both T cell subtypes and antileishmanial IgG2a isotype antibodies, before and after infection. Saponins 73-80 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 182-188 33485994-6 2021 BALB/c mice immunization with a DNA plasmid and recombinant protein plus saponin induced development of specific Th1-type immunity, characterized by high levels of IFN-gamma, IL-12, GM-CSF, both T cell subtypes and antileishmanial IgG2a isotype antibodies, before and after infection. Saponins 73-80 immunoglobulin heavy variable V1-9 Mus musculus 231-236 33781453-0 2021 Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer. Saponins 6-13 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 41-45 32980486-2 2021 Ginsenoside Rb1 (Rb1) is the most abundant triterpenoid saponin in Panax quinquefolius L., which has the function of Qi-invigorating and Yin-nourishing. Saponins 56-63 RB transcriptional corepressor 1 Homo sapiens 12-15 32980486-2 2021 Ginsenoside Rb1 (Rb1) is the most abundant triterpenoid saponin in Panax quinquefolius L., which has the function of Qi-invigorating and Yin-nourishing. Saponins 56-63 RB transcriptional corepressor 1 Homo sapiens 17-20 33131725-5 2021 The results of cellular assays showed that saponin 29 significantly inhibited LPS-induced secretion of pro-inflammatory factors TNF-alpha and IL-6 in THP1-derived macrophages. Saponins 43-50 tumor necrosis factor Mus musculus 128-137 33261954-9 2021 Flavonoid and saponin, two types of compounds in YPFG, were found to be the major active ingredients in the immunomodulatory effects of YPFG, and these components may regulate the abnormal metabolism of bile acids by enhancing the expression of FXR and LXRalpha. Saponins 14-21 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 245-248 33261954-9 2021 Flavonoid and saponin, two types of compounds in YPFG, were found to be the major active ingredients in the immunomodulatory effects of YPFG, and these components may regulate the abnormal metabolism of bile acids by enhancing the expression of FXR and LXRalpha. Saponins 14-21 nuclear receptor subfamily 1, group H, member 3 Rattus norvegicus 253-261 33425648-0 2021 In silico investigation of saponins and tannins as potential inhibitors of SARS-CoV-2 main protease (Mpro). Saponins 27-35 NEWENTRY Severe acute respiratory syndrome-related coronavirus 101-105 33425648-3 2021 Isolated saponins and tannins were evaluated for antiviral activity against SARS-CoV-2 (Mpro) via Molecular Docking and it was observed that a handsome number of the phytochemicals had binding affinities much better than Remdesivir, Dexamethasone, and N3 inhibitor which were used as the standards in this study. Saponins 9-17 NEWENTRY Severe acute respiratory syndrome-related coronavirus 88-92 33316029-9 2021 The effects of BTP2 on the RYR Ca2+ leak and release were abolished by pre-exposure to saponin, indicating that the effects of BTP2 on the RYR are not direct and require a functional t-system. Saponins 87-94 ryanodine receptor 2 Homo sapiens 27-30 33316029-9 2021 The effects of BTP2 on the RYR Ca2+ leak and release were abolished by pre-exposure to saponin, indicating that the effects of BTP2 on the RYR are not direct and require a functional t-system. Saponins 87-94 ryanodine receptor 2 Homo sapiens 139-142 33244850-0 2021 Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of alpha-synuclein through endoplasmic reticulum stress. Saponins 22-30 synuclein alpha Rattus norvegicus 128-143 33131725-5 2021 The results of cellular assays showed that saponin 29 significantly inhibited LPS-induced secretion of pro-inflammatory factors TNF-alpha and IL-6 in THP1-derived macrophages. Saponins 43-50 interleukin 6 Mus musculus 142-146 32963175-0 2020 Total Saponins from Paris Forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway. Saponins 6-14 phosphoglycolate phosphatase Homo sapiens 102-106 32963175-0 2020 Total Saponins from Paris Forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway. Saponins 6-14 mitogen-activated protein kinase 1 Homo sapiens 111-114 33259022-0 2020 Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF kappa B Pathway. Saponins 18-26 activating transcription factor 3 Rattus norvegicus 114-118 33259022-0 2020 Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF kappa B Pathway. Saponins 18-26 mitogen activated protein kinase kinase 3 Rattus norvegicus 119-125 33259022-0 2020 Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF kappa B Pathway. Saponins 18-26 mitogen activated protein kinase 14 Rattus norvegicus 126-134 33002483-0 2020 A spirostanol saponin isolated from Tupistra chinensis Baker simultaneously induces apoptosis and autophagy by regulating the JNK pathway in human gastric cancer cells. Saponins 14-21 mitogen-activated protein kinase 8 Homo sapiens 126-129 32725513-0 2020 Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Saponins 12-20 signal transducer and activator of transcription 3 Mus musculus 142-147 33139139-3 2020 Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Saponins 77-84 angiotensin converting enzyme 2 Homo sapiens 189-220 33139139-3 2020 Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Saponins 77-84 angiotensin converting enzyme 2 Homo sapiens 222-227 33230115-3 2020 When assayed in an IFNAR-/- mouse model, SBV-N with Saponin induced strong non-neutralizing broadly virus-reactive antibodies, decreased clinical signs, as well as significantly reduced viremia. Saponins 52-59 interferon (alpha and beta) receptor 1 Mus musculus 19-24 33228450-5 2021 In our previous study, Gp saponins (GpS) displayed prebiotic and cancer-preventive properties through the modulation of GM in Apc Min/+ mice. Saponins 26-34 APC, WNT signaling pathway regulator Mus musculus 126-129 33204574-2 2020 GmSg-1 gene is the key enzyme gene for synthesizing class A saponins. Saponins 60-68 glucosyltransferase Glycine max 0-6 33204574-6 2020 It was found that HCR has high specificity for GmSg-1 gene and could be applied to the visual detection of different soybean cultivars containing Aa type, Ab type, and Aa/Ab type saponins, which could provide technical reference and theoretical basis for molecular breeding of soybean and development of functional soybean products. Saponins 179-187 glucosyltransferase Glycine max 47-53 33146631-4 2021 The flavonoid and saponin-rich fractions showed in vitro hepatoprotective and antioxidant activity comparable to those of flavonoid complex silymarin (60 mug/mL) in a model of metabolic bioactivation, induced by CCl4. Saponins 18-25 C-C motif chemokine ligand 4 Rattus norvegicus 212-216 33122966-3 2020 Periploca forrestii Schltr saponin (PFS) was shown to potently inhibit murine arthritis by protecting bone and cartilage injury and suppressing NF-kappaB activation. Saponins 27-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 144-153 32771949-0 2020 Panax notoginseng saponin R1 modulates TNF-alpha/NF-kappaB signaling and attenuates allergic airway inflammation in asthma. Saponins 18-25 tumor necrosis factor Mus musculus 39-48 32771949-0 2020 Panax notoginseng saponin R1 modulates TNF-alpha/NF-kappaB signaling and attenuates allergic airway inflammation in asthma. Saponins 18-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 49-58 33192124-2 2020 Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation. Saponins 14-21 NLR family, pyrin domain containing 3 Mus musculus 74-79 33192124-2 2020 Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation. Saponins 14-21 absent in melanoma 2 Mus musculus 84-88 33192124-3 2020 In this study, we investigated the effect of non-saponin components of RGE on AIM2 inflammasome activation. Saponins 49-56 absent in melanoma 2 Mus musculus 78-82 33192124-7 2020 Results: The non-saponin fraction and saponin-eliminating fraction (SEF) of RGE selectively attenuated the activation of AIM2 inflammasomes, but not that of NLRP3 or NLRC4 inflammasomes. Saponins 38-45 absent in melanoma 2 Mus musculus 121-125 33192124-9 2020 Conclusion: Non-saponins of RGE, such as fructose-arginine, might be effective in regulating infectious and autoimmune diseases resulting from AIM2 inflammasome activation. Saponins 16-24 absent in melanoma 2 Mus musculus 143-147 32823242-3 2020 PURPOSE: We aimed to investigate the proangiogenic activity of notoginsenoside R1 (NR1) isolated from total saponins of Panax notoginseng with regard to activation of the Ang2/Tie2 signaling pathway. Saponins 108-116 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 83-86 32823242-3 2020 PURPOSE: We aimed to investigate the proangiogenic activity of notoginsenoside R1 (NR1) isolated from total saponins of Panax notoginseng with regard to activation of the Ang2/Tie2 signaling pathway. Saponins 108-116 angiopoietin 2b Danio rerio 171-175 32945421-0 2020 Panax notoginseng Saponins protect auditory cells against cisplatin-induced ototoxicity by inducing the AKT/Nrf2 signaling-mediated redox pathway. Saponins 18-26 AKT serine/threonine kinase 1 Homo sapiens 104-107 33176641-0 2021 Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats. Saponins 18-26 thioredoxin interacting protein Rattus norvegicus 63-68 33176641-0 2021 Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats. Saponins 18-26 NLR family, pyrin domain containing 3 Rattus norvegicus 78-83 32945421-0 2020 Panax notoginseng Saponins protect auditory cells against cisplatin-induced ototoxicity by inducing the AKT/Nrf2 signaling-mediated redox pathway. Saponins 18-26 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 32707371-5 2020 By combining affinity ultrafiltration and high-performance liquid chromatography-mass spectrometry (AUF-LC-MS), an efficient method was developed to identify spirostanol glycosides and furostanol glycosides as the 5-LOX/COX-2 dual inhibitors from saponins extract of Anemarrhenae Rhizoma (SEAR). Saponins 247-255 arachidonate 5-lipoxygenase Homo sapiens 214-219 33042284-0 2020 Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKalpha/STAT3 signaling in diet-induced obesity. Saponins 18-26 leptin Mus musculus 119-125 32446927-0 2020 Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. Saponins 59-66 AKT serine/threonine kinase 1 Homo sapiens 140-143 33042284-0 2020 Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKalpha/STAT3 signaling in diet-induced obesity. Saponins 18-26 signal transducer and activator of transcription 3 Mus musculus 145-150 32446927-0 2020 Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. Saponins 59-66 mechanistic target of rapamycin kinase Homo sapiens 144-148 32843018-0 2020 Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica Makino on rats with gouty arthritis by influencing MAPK signalling pathway. Saponins 39-46 mitogen activated protein kinase 3 Rattus norvegicus 132-136 32864368-14 2020 Conclusion: The prepared vaccine, namely Pneumo-5, and adjuvanted with either 1 or 1.5 mg/dose saponin was proved safe and potent for effectual protection of calves against BVDV genotypes 1 and 2, BoHV-1.1, BPI-3V, and BRSV. Saponins 95-102 bpi-3v None 207-213 32485185-0 2020 A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma. Saponins 12-19 AKT serine/threonine kinase 1 Homo sapiens 120-123 32485185-0 2020 A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma. Saponins 12-19 mechanistic target of rapamycin kinase Homo sapiens 124-128 32655683-0 2020 Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions. Saponins 35-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-108 32655683-0 2020 Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions. Saponins 35-43 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 113-140 32821440-4 2020 ChimeraT/saponin vaccine stimulated significantly higher levels of IFN-gamma, IL-12, and GM-CSF cytokines by both murine CD4+ and CD8+ T cells, with correspondingly low levels of IL-4 and IL-10. Saponins 9-16 interferon gamma Mus musculus 67-76 32821440-4 2020 ChimeraT/saponin vaccine stimulated significantly higher levels of IFN-gamma, IL-12, and GM-CSF cytokines by both murine CD4+ and CD8+ T cells, with correspondingly low levels of IL-4 and IL-10. Saponins 9-16 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 89-95 32821440-4 2020 ChimeraT/saponin vaccine stimulated significantly higher levels of IFN-gamma, IL-12, and GM-CSF cytokines by both murine CD4+ and CD8+ T cells, with correspondingly low levels of IL-4 and IL-10. Saponins 9-16 CD4 antigen Mus musculus 121-124 32821440-4 2020 ChimeraT/saponin vaccine stimulated significantly higher levels of IFN-gamma, IL-12, and GM-CSF cytokines by both murine CD4+ and CD8+ T cells, with correspondingly low levels of IL-4 and IL-10. Saponins 9-16 interleukin 4 Mus musculus 179-183 32821440-4 2020 ChimeraT/saponin vaccine stimulated significantly higher levels of IFN-gamma, IL-12, and GM-CSF cytokines by both murine CD4+ and CD8+ T cells, with correspondingly low levels of IL-4 and IL-10. Saponins 9-16 interleukin 10 Mus musculus 188-193 32802113-0 2020 In Vitro Evaluation of the Neuroprotective Effect of Panax notoginseng Saponins by Activating the EGFR/PI3K/AKT Pathway. Saponins 71-79 epidermal growth factor receptor Homo sapiens 98-102 32802113-0 2020 In Vitro Evaluation of the Neuroprotective Effect of Panax notoginseng Saponins by Activating the EGFR/PI3K/AKT Pathway. Saponins 71-79 AKT serine/threonine kinase 1 Homo sapiens 108-111 32583791-4 2020 Some bioactive compounds, in particular phenolic compounds, saponins and alkaloids have revealed good abilities to affect p53 expression and indirectly control the telomere length. Saponins 60-68 tumor protein p53 Homo sapiens 122-125 32583791-6 2020 As main findings, phenolic compounds, saponins and alkaloids interfere with cancer progression by stimulating p53 expression, which can cause pro-apoptotic onset and restrict the anti-apoptotic activity, in addition to preventing telomerase enzyme activity. Saponins 38-46 tumor protein p53 Homo sapiens 110-113 33335762-3 2020 Notoginsenoside R1 (NGR1), a saponin isolated from Panax notoginseng, has been shown to exert neuroprotective effects. Saponins 29-36 reticulon 4 receptor Rattus norvegicus 20-24 32372871-1 2020 Background: Ginsenoside Rk1, a saponin component isolated from heat-processed Panax ginseng Meyer, has been implicated in the regulation of antitumor and anti-inflammatory activities. Saponins 31-38 kallikrein 1-related peptidase B3 Rattus norvegicus 24-27 32145316-0 2020 Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. Saponins 43-51 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 99-102 32145316-4 2020 Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro. Saponins 78-85 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 137-140 32145316-4 2020 Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro. Saponins 78-85 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 167-173 32145316-5 2020 In the study of CYP, polyphyllin VI exhibited weak inhibition on CYP2D1 activity in rat liver microsomes with IC50 value at 45.2 muM, while paris saponin VII weakly inhibited CYP2C11 and CYP2E1 activities with IC50 value at 42.0 and 67.7 muM, respectively. Saponins 146-153 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 175-182 32427081-0 2021 Saponins from the sea cucumber promotes the osteoblast differentiation in MC3T3-E1 cells through activation of BMP2/Smads pathway. Saponins 0-8 bone morphogenetic protein 2 Mus musculus 111-115 32427081-8 2021 CONCLUSION: SCS promoted osteogenic differentiation of pre-osteoblasts by activating BMP2/Smads molecular pathway, providing theoretical basis for the development of sea cucumber saponins for the treatment to bone loss diseases such as osteoporosis. Saponins 179-187 bone morphogenetic protein 2 Mus musculus 85-89 32575028-1 2020 BACKGROUND: P. chinensis saponins (PRS) are pentacyclic triterpenoid bioactive constituents from Pulsatilla chinensis (Bunge) Regel. Saponins 25-33 PRS Homo sapiens 35-38 32595508-11 2020 In addition, also an aqueous extract containing high amounts of isoflavonoid glycosides and saponins from the roots of O. spinosa showed anti-inflammatory effects by interacting with the TLR4 signaling pathway. Saponins 92-100 toll like receptor 4 Homo sapiens 187-191 32348180-4 2020 Using CRISPR gene-edited HEK293 cell lines, we establish that loss of both calpains-1 and -2 (CAPNS1-/-) virtually ablates Ca2+-dependent repair of mechanical scrape injuries, though does not affect injury or recovery from perforation by streptolysin-O or saponin. Saponins 256-263 calpain 1 Homo sapiens 75-92 32348180-4 2020 Using CRISPR gene-edited HEK293 cell lines, we establish that loss of both calpains-1 and -2 (CAPNS1-/-) virtually ablates Ca2+-dependent repair of mechanical scrape injuries, though does not affect injury or recovery from perforation by streptolysin-O or saponin. Saponins 256-263 calpain small subunit 1 Homo sapiens 94-100 32381364-0 2020 Astragalus saponin IV promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-21/NGF/BMP2/Runx2 pathway. Saponins 11-18 microRNA 21 Homo sapiens 100-106 32381364-0 2020 Astragalus saponin IV promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-21/NGF/BMP2/Runx2 pathway. Saponins 11-18 nerve growth factor Homo sapiens 107-110 32381364-0 2020 Astragalus saponin IV promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-21/NGF/BMP2/Runx2 pathway. Saponins 11-18 bone morphogenetic protein 2 Homo sapiens 111-115 32381364-0 2020 Astragalus saponin IV promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-21/NGF/BMP2/Runx2 pathway. Saponins 11-18 RUNX family transcription factor 2 Homo sapiens 116-121 32299503-0 2020 DPYSL2 is a novel regulator for neural stem cell differentiation in rats: revealed by Panax notoginseng saponin administration. Saponins 104-111 dihydropyrimidinase-like 2 Rattus norvegicus 0-6 32382308-0 2020 Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins. Saponins 145-153 apolipoprotein E Mus musculus 93-109 32382308-1 2020 This study investigated whether Panax notoginseng saponins (PNS) reduced atherosclerotic lesion formation in apolipoprotein E knockout (ApoE-KO) mice and illustrated the potential mechanism for a network pharmacology approach. Saponins 50-58 apolipoprotein E Mus musculus 109-125 32382308-1 2020 This study investigated whether Panax notoginseng saponins (PNS) reduced atherosclerotic lesion formation in apolipoprotein E knockout (ApoE-KO) mice and illustrated the potential mechanism for a network pharmacology approach. Saponins 50-58 apolipoprotein E Mus musculus 136-140 31678415-4 2020 AIM OF STUDY: Our previous study indicated that saponins extracted from AC (ACS) were the active anti-HBV ingredients in AC. Saponins 48-56 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 76-79 31891798-0 2020 Anti-cancer activity of Conyza blinii saponin against cervical carcinoma through MAPK/TGF-beta/Nrf2 signaling pathways. Saponins 38-45 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 31986407-0 2020 Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP/p16 signals via m6A modulation. Saponins 24-31 WT1 associated protein Rattus norvegicus 135-139 32256588-0 2020 Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. Saponins 0-7 roundabout guidance receptor 1 Homo sapiens 25-30 32256588-7 2020 Treatment with saponin facilitated significant cytotoxic effects of IT-Robo1 on HSQ-89 cells. Saponins 15-22 roundabout guidance receptor 1 Homo sapiens 71-76 32224542-2 2020 OBJECTIVE: To investigate the effect of aqueous extract and saponin fraction of Tribulus terrestris L. (TT) on the proteome and expression of intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in the human umbilical vein endothelial cell (HUVEC) and human bone marrow endothelial cell (HBMEC) lines. Saponins 60-67 intercellular adhesion molecule 1 Homo sapiens 142-175 32224542-2 2020 OBJECTIVE: To investigate the effect of aqueous extract and saponin fraction of Tribulus terrestris L. (TT) on the proteome and expression of intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in the human umbilical vein endothelial cell (HUVEC) and human bone marrow endothelial cell (HBMEC) lines. Saponins 60-67 intercellular adhesion molecule 1 Homo sapiens 177-183 32224542-9 2020 CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. Saponins 31-38 intercellular adhesion molecule 1 Homo sapiens 137-143 32224542-9 2020 CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. Saponins 31-38 vascular cell adhesion molecule 1 Homo sapiens 145-151 32224542-9 2020 CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. Saponins 31-38 selectin E Homo sapiens 157-167 32461350-0 2020 Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes. Saponins 49-56 interleukin 1 alpha Homo sapiens 75-79 32461350-6 2020 The combination of CpG and saponin-based adjuvants induces potent DC maturation (mainly CpG-mediated), antigen cross-presentation (mainly saponin-based adjuvant mediated), while excretion of IL-1beta by DCs in vitro depends on the presence of both adjuvants. Saponins 27-34 interleukin 1 alpha Homo sapiens 191-199 32124939-0 2020 Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K-AKT-mTOR pathway in osteoarthritic chondrocytes. Saponins 18-26 AKT serine/threonine kinase 1 Rattus norvegicus 91-94 32124939-0 2020 Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K-AKT-mTOR pathway in osteoarthritic chondrocytes. Saponins 18-26 mechanistic target of rapamycin kinase Rattus norvegicus 95-99 31972205-2 2020 It has been reported that ginseng saponin extract (GSE) has an inhibitory effect on the hyperactivity of the HPA axis induced by stresses and increased corticosterone level induced by intraperitoneal injection of adrenocorticotrophic hormone (ACTH) in mice. Saponins 34-41 pro-opiomelanocortin-alpha Mus musculus 243-247 32309379-2 2020 Ginsenoside Rg1 (GRg1), a major saponin in ginseng, exerts high anti-apoptotic activity. Saponins 32-39 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 32012760-0 2020 Mechanisms of Mixed Th1/Th2 Responses in Mice Induced by Albizia julibrissin Saponin Active Fraction by in Silico Analysis. Saponins 77-84 negative elongation factor complex member C/D, Th1l Mus musculus 20-23 32158393-9 2020 In addition, these three saponins induced autophagic flux by increasing the ratio of RFP-LC3 to GFP-LC3, and by decreasing P62 expression. Saponins 25-33 microtubule-associated protein 1 light chain 3 alpha Mus musculus 89-92 32158393-9 2020 In addition, these three saponins induced autophagic flux by increasing the ratio of RFP-LC3 to GFP-LC3, and by decreasing P62 expression. Saponins 25-33 nucleoporin 62 Mus musculus 123-126 30470136-0 2020 A new tetracyclic saponin from Astragalus glycyphyllos L. and its neuroprotective and hMAO-B inhibiting activity. Saponins 18-25 monoamine oxidase B Homo sapiens 86-92 31560992-7 2020 RESULTS: Daucosterol (CA2), a steroid saponin, was identified as major anticancer principle of the C. adansonii extract. Saponins 38-45 carbonic anhydrase 2 Homo sapiens 22-25 32093087-7 2020 Significant correlations were found between the total polyphenols, flavonoids or saponins content in the two selected SDEOs and Th1/Th2 immune balance or anti-inflammatory ability in linear, non-linear or biphasic manners, respectively. Saponins 81-89 heart and neural crest derivatives expressed 2 Mus musculus 132-135 31988091-3 2020 Polyphyllin II (PP2), an important steroidal saponin extracted from Rhizoma Paris, has emerged as a potential anticancer agent, but the effects of PP2 in liver cancers and its underlying mechanisms remain unexplored. Saponins 35-52 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 16-19 31913047-7 2020 Five saponins showed strong endosomal escape activity, enhancing MAP30-HBP cytotoxicity by more than 106 to 109 folds. Saponins 5-13 heme binding protein 1 Homo sapiens 71-74 31913047-8 2020 These saponins also enhanced the apoptotic effect of MAP30-HBP in a pH-dependent manner. Saponins 6-14 heme binding protein 1 Homo sapiens 59-62 31913047-9 2020 Additionally, growth inhibition of MAP30-HBP-treated SMMC-7721 cells was greater than that of similarly treated HeLa cells, suggesting that saponin-mediated endosomolytic effect is likely to be cell-specific. Saponins 140-147 heme binding protein 1 Homo sapiens 41-44 32012760-0 2020 Mechanisms of Mixed Th1/Th2 Responses in Mice Induced by Albizia julibrissin Saponin Active Fraction by in Silico Analysis. Saponins 77-84 heart and neural crest derivatives expressed 2 Mus musculus 24-27 31986489-2 2020 Araloside C (AsC), a natural saponin, exerts extensive anti-inflammatory properties. Saponins 29-36 steroid sulfatase Mus musculus 0-11 31986489-2 2020 Araloside C (AsC), a natural saponin, exerts extensive anti-inflammatory properties. Saponins 29-36 steroid sulfatase Mus musculus 13-16 32012760-1 2020 The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate that improves antigen-specific both cellular and humoral immune responses and elicits mixed Th1/Th2 responses, but its mechanisms remain unclear. Saponins 52-59 negative elongation factor complex member C/D, Th1l Mus musculus 191-194 32012760-1 2020 The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate that improves antigen-specific both cellular and humoral immune responses and elicits mixed Th1/Th2 responses, but its mechanisms remain unclear. Saponins 52-59 heart and neural crest derivatives expressed 2 Mus musculus 195-198 31969494-0 2020 Chikusetsu saponin IVa protects pancreatic beta cell against intermittent high glucose-induced injury by activating Wnt/beta-catenin/TCF7L2 pathway. Saponins 11-18 catenin (cadherin associated protein), beta 1 Mus musculus 120-132 31969494-0 2020 Chikusetsu saponin IVa protects pancreatic beta cell against intermittent high glucose-induced injury by activating Wnt/beta-catenin/TCF7L2 pathway. Saponins 11-18 transcription factor 7 like 2, T cell specific, HMG box Mus musculus 133-139 30582348-6 2020 This review summarizes the biological and pharmacological activities of typical saponins mediated by some of the most well described nuclear receptors, including the classical steroid hormone receptors (ER, GR, MR, and AR) and the adopted orphan receptors (PPAR, LXR, FXR, and PXR). Saponins 80-88 peroxisome proliferator activated receptor alpha Homo sapiens 257-261 32015754-4 2020 Our research found that panax notoginseng saponins (PNS), especially panaxadiol saponins (PDS) and its aglucon 20(S)-Protopanaxdiol (PPD), could improve the immunosuppressive state by regulating the abnormal hematopoietic differentiation in a tumor-bearing body by multiple ways. Saponins 42-50 DNA segment, 20S Mus musculus 111-131 30582348-6 2020 This review summarizes the biological and pharmacological activities of typical saponins mediated by some of the most well described nuclear receptors, including the classical steroid hormone receptors (ER, GR, MR, and AR) and the adopted orphan receptors (PPAR, LXR, FXR, and PXR). Saponins 80-88 nuclear receptor subfamily 1 group H member 4 Homo sapiens 268-271 30582348-6 2020 This review summarizes the biological and pharmacological activities of typical saponins mediated by some of the most well described nuclear receptors, including the classical steroid hormone receptors (ER, GR, MR, and AR) and the adopted orphan receptors (PPAR, LXR, FXR, and PXR). Saponins 80-88 nuclear receptor subfamily 1 group I member 2 Homo sapiens 277-280 32832486-0 2020 Saponins from Tribulus terrestris L. Extract Down-regulate the Expression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines. Saponins 0-8 intercellular adhesion molecule 1 Homo sapiens 77-83 31715069-0 2020 Panax notoginseng saponins (PNS) ameliorate cisplatin-induced mitochondrial injury via the HIF-1alpha/mitochondria/ROS pathway. Saponins 18-26 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 91-101 31715069-3 2020 Our previous studies have indicated that Panax notoginseng saponins (PNS) mitigate CIN by enhancing HIF-1alpha-induced mitochondrial autophagy. Saponins 59-67 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 100-110 31746361-0 2020 Rhizoma Paridis total saponins alleviate H2O2-induced oxidative stress injury by upregulating the Nrf2 pathway. Saponins 22-30 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 31873810-5 2019 RESULTS: Increased endolysosomal escape of saporin and OKT10-SAP was observed by confocal microscopy in cells treated with saponin. Saponins 123-130 SH2 domain containing 1A Homo sapiens 61-64 31688993-0 2020 Paris saponin VII enhanced the sensitivity of HepG2/ADR cells to ADR via modulation of PI3K/AKT/MAPK signaling pathway. Saponins 6-13 AKT serine/threonine kinase 1 Homo sapiens 92-95 31688993-1 2020 To find the effect of Paris saponin VII (PS VII)-mediated PI3K/AKT/MAPK signaling pathway on the sensitivity of ADR-resistant HepG2 cell (HepG2/ADR) cells to ADR. Saponins 28-35 AKT serine/threonine kinase 1 Homo sapiens 63-66 32015677-0 2020 Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKCdelta. Saponins 11-18 protein kinase C, delta Mus musculus 101-109 31921219-7 2019 By analyzing phosphorylation of interferon regulatory factor 3 (IRF3) in cell culture, we provide evidence that the saponin component increases access of exogenous cGAMP to the intracellular STING pathway. Saponins 116-123 interferon regulatory factor 3 Mus musculus 32-62 31921219-7 2019 By analyzing phosphorylation of interferon regulatory factor 3 (IRF3) in cell culture, we provide evidence that the saponin component increases access of exogenous cGAMP to the intracellular STING pathway. Saponins 116-123 interferon regulatory factor 3 Mus musculus 64-68 31864413-2 2019 This study aims to explore the immunosuppressive activity of SBF-1, an analog of saponin OSW-1, against T lymphocytes in vitro and in vivo. Saponins 81-88 SET binding factor 1 Mus musculus 61-66 31678552-1 2019 OBJECTIVES: Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. Saponins 44-51 ferredoxin reductase Mus musculus 31-33 31678552-1 2019 OBJECTIVES: Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. Saponins 44-51 ferredoxin reductase Mus musculus 35-37 32832486-0 2020 Saponins from Tribulus terrestris L. Extract Down-regulate the Expression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines. Saponins 0-8 vascular cell adhesion molecule 1 Homo sapiens 85-91 32832486-0 2020 Saponins from Tribulus terrestris L. Extract Down-regulate the Expression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines. Saponins 0-8 selectin E Homo sapiens 96-106 32832486-3 2020 Due to the anti-inflammatory activity of Tribulus terrestris (TT), the present study investigated the effect of aqueous extract and saponin fraction of TT on the expression of ICAM-1, VCAM-1, and SELE genes in endothelial cells during normal and lipopolysaccharide (LPS) induced conditions. Saponins 132-139 intercellular adhesion molecule 1 Homo sapiens 176-182 32832486-3 2020 Due to the anti-inflammatory activity of Tribulus terrestris (TT), the present study investigated the effect of aqueous extract and saponin fraction of TT on the expression of ICAM-1, VCAM-1, and SELE genes in endothelial cells during normal and lipopolysaccharide (LPS) induced conditions. Saponins 132-139 vascular cell adhesion molecule 1 Homo sapiens 184-190 31885672-2 2019 SSb2 is only found in aqueous Bupleuri Radix extract, and it is one of the secondary saponins derived from saikosaponin d (SSd), which exists in the methanolic extract. Saponins 85-93 nucleic acid binding protein 1 Mus musculus 0-4 31612532-0 2019 Saponin-rich extracts from Holothuria leucospilota mediate lifespan extension and stress resistance in Caenorhabditis elegans via daf-16. Saponins 0-7 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 130-136 31678866-0 2019 Activation of RAW264.7 macrophages by active fraction of Albizia julibrissin saponin via Ca2+-ERK1/2-CREB-lncRNA pathways. Saponins 77-84 mitogen-activated protein kinase 3 Mus musculus 94-100 31678866-0 2019 Activation of RAW264.7 macrophages by active fraction of Albizia julibrissin saponin via Ca2+-ERK1/2-CREB-lncRNA pathways. Saponins 77-84 cAMP responsive element binding protein 1 Mus musculus 101-105 31612532-8 2019 Taken together, this study revealed the evidences on anti-aging activities of saponin-rich extracts from H. leucospilota, which can extend lifespan of C. elegans via daf-16. Saponins 78-85 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 166-172 31489680-10 2019 Qualitative characterisation of APM indicated existence of alkaloids, terpenoids, coumarins, cardiac glycosides, phenols, flavonoids, saponins, tannins and sterols. Saponins 134-142 alanyl aminopeptidase, membrane Rattus norvegicus 32-35 30734590-1 2019 Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). Saponins 19-27 aldo-keto reductase family 1 member B Homo sapiens 221-237 30734590-1 2019 Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). Saponins 19-27 aldo-keto reductase family 1 member B Homo sapiens 239-246 31468630-0 2019 Panax notoginseng saponins suppress lipopolysaccharide-induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF-kappaB inflammatory pathways. Saponins 18-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 151-155 31468630-0 2019 Panax notoginseng saponins suppress lipopolysaccharide-induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF-kappaB inflammatory pathways. Saponins 18-26 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 172-181 31629869-4 2019 Various lignans and saponins showed the significant activities, they could obviously inhibit the growth of tumor cells and the release of NO and TNF-alpha in RAW 264.7 cells induced by LPS. Saponins 20-28 tumor necrosis factor Mus musculus 145-154 31368122-1 2019 Notoginsenoside R1 (NGR1 ), a diagnostic protopanaxatriol-type (ppt-type) saponin in Panax notoginseng, possesses potent biological activities including antithrombotic, anti-inflammatory, neuron protection and improvement of microcirculation, yet its pharmacokinetics and metabolic characterization as an individual compound remain unclear. Saponins 74-81 reticulon 4 receptor Rattus norvegicus 20-24 31357337-5 2019 The MCS assay was linear within the range of 9.039-180.773 x 10-4 mg mL-1 of saponin (R2 = 0.9929), using the integrated density/area as a foam measurement (Y) and the logarithm of saponin concentration (X) (Y = 372.1 + 104.2LogX). Saponins 77-84 L1 cell adhesion molecule Mus musculus 69-73 31237033-3 2019 Moreover, saponin induced IL1beta and MCP1 release and did not affect the complement system. Saponins 10-17 interleukin 1 beta Homo sapiens 26-33 31680950-3 2019 In this study, we investigated the effect of ginsenoside Rb1 (Rb1), a saponin derived from Panax ginseng Meyer, on browning. Saponins 70-77 RB transcriptional corepressor 1 Mus musculus 57-60 31680950-3 2019 In this study, we investigated the effect of ginsenoside Rb1 (Rb1), a saponin derived from Panax ginseng Meyer, on browning. Saponins 70-77 RB transcriptional corepressor 1 Mus musculus 62-65 31662772-1 2019 The current study investigates the inhibitory effects of Pulsatilla pentacyclic triterpenoid saponins extract (PPTS) on epithelial-mesenchymal transition (EMT) triggered by the transforming growth factor-beta1 (TGF-beta1) in human colorectal cancer SW480 cell line, further illustrates the possible mechanism of PPTS inhibition of growth and invasion from the perspective of EMT, and provides new theoretical support for the treatment of tumor by Chinese medicine. Saponins 68-101 transforming growth factor beta 1 Homo sapiens 177-209 31662772-1 2019 The current study investigates the inhibitory effects of Pulsatilla pentacyclic triterpenoid saponins extract (PPTS) on epithelial-mesenchymal transition (EMT) triggered by the transforming growth factor-beta1 (TGF-beta1) in human colorectal cancer SW480 cell line, further illustrates the possible mechanism of PPTS inhibition of growth and invasion from the perspective of EMT, and provides new theoretical support for the treatment of tumor by Chinese medicine. Saponins 68-101 transforming growth factor beta 1 Homo sapiens 211-220 31237033-3 2019 Moreover, saponin induced IL1beta and MCP1 release and did not affect the complement system. Saponins 10-17 C-C motif chemokine ligand 2 Homo sapiens 38-42 30945345-3 2019 Platycodin D (PLD) is a triterpenoid saponin that exhibits antioxidant properties. Saponins 37-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 29457747-3 2019 The isolated saponin (1) displayed significant cytotoxic activity against the human glioblastoma cell line U-87 MG and TG1 stem-like glioma cells isolated from a patient tumor with IC50 values of 1.69 and 1.44 muM, respectively. Saponins 13-20 latexin Homo sapiens 210-213 30945455-0 2019 Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1-PI3K-AKT signaling pathway and GLUT4 expression. Saponins 18-26 insulin receptor substrate 1 Mus musculus 90-94 31934124-0 2019 Paris saponin H suppresses human hepatocellular carcinoma (HCC) by inactivation of Wnt/beta-catenin pathway in vitro and in vivo. Saponins 6-13 catenin beta 1 Homo sapiens 87-99 31182089-0 2019 Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. Saponins 18-26 thymoma viral proto-oncogene 1 Mus musculus 85-88 31182089-0 2019 Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. Saponins 18-26 mechanistic target of rapamycin kinase Mus musculus 89-93 31182089-0 2019 Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. Saponins 18-26 thymoma viral proto-oncogene 1 Mus musculus 145-148 30878903-2 2019 Numerous researches have proved that the dammarane type saponins including notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1) and ginsenoside Rb1 (GRb1) are the main bioactive components of PN in CDDP. Saponins 56-64 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 95-98 30878903-3 2019 An efficient, realiable and sensitive liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis method for simultaneously detecting NR1, GRg1 and GRb1 in human plasma was established and applied to the pharmacokinetics study of the three PN saponins after oral administration of CDDP. Saponins 250-258 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 141-144 31086211-0 2019 The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol. Saponins 20-27 Rh associated glycoprotein Homo sapiens 40-43 31086211-2 2019 This contrasts with our recent publication showing that Chol, contrary to sphingomyelin (SM), can delay the cytotoxicity of the saponin ginsenoside Rh2, challenging the usual view that most saponins mediate their membrane effects through interaction with Chol. Saponins 128-135 Rh associated glycoprotein Homo sapiens 148-151 31065079-1 2019 Ginsenoside Rg1, a natural triterpenoid saponins compound isolated from the Panax species, has been found to possess neuroprotective properties in neurodegenerative diseases such as Alzheimer"s disease (AD). Saponins 40-48 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 31310523-3 2019 To produce ginsenosides Rh2 and Rg3, the saponin-producing capacity of endophytic bacteria isolated from Panax ginseng was investigated. Saponins 41-48 Rh associated glycoprotein Homo sapiens 24-27 31308811-1 2019 Background: Ginsenoside Rb1, a triterpene saponin, is derived from the Panax ginseng root and has potent antiinflammatory activity. Saponins 42-49 RB transcriptional corepressor 1 Mus musculus 24-27 31308821-1 2019 Background: Timosaponin AIII (TA3) is a steroidal saponin extracted from Anemarrhena asphodeloides. Saponins 16-23 trace amine associated receptor 9 Homo sapiens 30-33 29882435-2 2019 In addition, the ability of metanolic extract and saponins to modulate the interleukin-2 production in PHA/PMA stimulated Jurkat E6-1 cells was investigated as well. Saponins 50-58 interleukin 2 Homo sapiens 75-88 30327544-0 2019 Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions. Saponins 21-29 ornithine aminotransferase pseudogene 1 Homo sapiens 63-68 30327544-4 2019 Inhibition of human OATP1B1/1B3 and rat Oatp1b2 by the individual saponins was investigated in vitro; the compounds" joint inhibition was also assessed in vitro and the data was processed using the Chou-Talalay method. Saponins 66-74 solute carrier organic anion transporter family member 1B1 Homo sapiens 20-31 30945455-0 2019 Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1-PI3K-AKT signaling pathway and GLUT4 expression. Saponins 18-26 thymoma viral proto-oncogene 1 Mus musculus 100-103 30945455-0 2019 Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1-PI3K-AKT signaling pathway and GLUT4 expression. Saponins 18-26 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 126-131 30905075-3 2019 In the present study, we showed that raddeanin A (RA), an oleanane-type triterpenoid saponin, suppresses the transcriptional activities of both the full-length and the splice variants of AR. Saponins 85-92 androgen receptor Homo sapiens 187-189 31144047-6 2019 RESULTS: Correlation analyses between gene expression and saponin accumulation revealed high correlations between saponin content with gene expression of beta-amyrin synthase, MtCYP716A12, and two cytochromes P450 genes, MtCYP72A67 and MtCYP72A68. Saponins 114-121 beta-amyrin synthase Medicago truncatula 154-174 31005723-0 2019 Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. Saponins 11-18 mechanistic target of rapamycin kinase Mus musculus 129-133 31005723-0 2019 Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. Saponins 11-18 unc-51 like kinase 1 Mus musculus 134-138 31342718-27 2019 All the results suggested that the ethanol extract of CAC had remarkable diuretic activity and its main effective components included sterol,triterpenoid saponin and lignin glycosides. Saponins 154-161 solute carrier family 25 member 20 Rattus norvegicus 54-57 30864725-1 2019 Ginsenoside Rb1 (GRb1), one of the major active saponins isolated from ginseng, has recently been reported to protect various organs against ischemia/reperfusion (IR) injury; however, the mechanisms underlying these protective effects following intestinal IR (IIR) remain unclear. Saponins 48-56 RB transcriptional corepressor 1 Rattus norvegicus 12-15 30930854-1 2019 Ginsenoside Rb2 (Rb2), the most abundant saponin contained in Panax ginseng, has been used to treat variety of metabolic diseases. Saponins 41-48 RB transcriptional corepressor like 2 Mus musculus 12-15 30549041-2 2019 Based on the dual-directional regulatory effect of Panax notoginseng on platelet, the present study focused on the effect of Notoginsenoside Ft1, a saponin with effect in promoting platelet aggregation. Saponins 148-155 AKT interacting protein Homo sapiens 141-144 30930854-1 2019 Ginsenoside Rb2 (Rb2), the most abundant saponin contained in Panax ginseng, has been used to treat variety of metabolic diseases. Saponins 41-48 RB transcriptional corepressor like 2 Mus musculus 17-20 30697065-0 2019 Erratum: Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells [Corrigendum]. Saponins 20-28 AKT serine/threonine kinase 1 Homo sapiens 55-58 30587668-0 2019 Panax notoginseng Saponins Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155. Saponins 18-26 microRNA 155 Homo sapiens 177-184 30795644-2 2019 To verify the therapeutic effects of saponin-enriched extracts of Asparagus cochinchinensis (SPA) on the anti-inflammatory response and on the cholinergic regulation in the gastrointestinal system, an alteration on the constipation phenotypes, on the inflammatory responses, and on the muscarinic cholinergic regulation were investigated in the transverse colons of Sprague Dawley (SD) rats with loperamide (Lop)-induced constipation after the treatment of SPA. Saponins 37-44 surfactant protein A1 Rattus norvegicus 93-96 30795644-2 2019 To verify the therapeutic effects of saponin-enriched extracts of Asparagus cochinchinensis (SPA) on the anti-inflammatory response and on the cholinergic regulation in the gastrointestinal system, an alteration on the constipation phenotypes, on the inflammatory responses, and on the muscarinic cholinergic regulation were investigated in the transverse colons of Sprague Dawley (SD) rats with loperamide (Lop)-induced constipation after the treatment of SPA. Saponins 37-44 surfactant protein A1 Rattus norvegicus 457-460 30622216-0 2019 Gustatory receptor 28b is necessary for avoiding saponin in Drosophila melanogaster. Saponins 49-56 Myosin 28B1 Drosophila melanogaster 19-22 30622216-3 2019 Using a behavioral screen of 26 mutant fly lines, we show that the Gr28b gene cluster plays a role in saponin avoidance in the labellum. Saponins 102-109 Gustatory receptor 28b Drosophila melanogaster 67-72 30622216-4 2019 The Gr28b mutant does not avoid saponin and exhibits increased lethality when fed saponin-mixed food. Saponins 32-39 Gustatory receptor 28b Drosophila melanogaster 4-9 30622216-4 2019 The Gr28b mutant does not avoid saponin and exhibits increased lethality when fed saponin-mixed food. Saponins 82-89 Gustatory receptor 28b Drosophila melanogaster 4-9 30622216-5 2019 Tissue-specific rescue experiments with five different Gr28b isoforms revealed that only the Gr28b.c isoform is required for saponin sensation. Saponins 125-132 Gustatory receptor 28b Drosophila melanogaster 55-60 30622216-5 2019 Tissue-specific rescue experiments with five different Gr28b isoforms revealed that only the Gr28b.c isoform is required for saponin sensation. Saponins 125-132 Gustatory receptor 28b Drosophila melanogaster 93-100 32328572-0 2019 Saponins of Dioscorea Nipponicae Inhibits IL-17A-Induced Changes in Biomechanical Behaviors of In Vitro Cultured Human Airway Smooth Muscle Cells. Saponins 0-8 interleukin 17A Homo sapiens 42-48 32328572-4 2019 One potential candidate is the inexpensive and widely available natural herb saponins of Dioscorea nipponicae (SDN), which has recently been reported to suppress the level of inflammatory factor IL-17A in ovalbumin-induced mice, thereby alleviating the inflammation symptoms of asthma. Saponins 77-85 interleukin 17A Mus musculus 195-201 32328572-4 2019 One potential candidate is the inexpensive and widely available natural herb saponins of Dioscorea nipponicae (SDN), which has recently been reported to suppress the level of inflammatory factor IL-17A in ovalbumin-induced mice, thereby alleviating the inflammation symptoms of asthma. Saponins 77-85 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 205-214 30832367-2 2019 Notoginsenoside R1 (NGR1), a novel saponin extracted from Panax notoginseng, posesses pharmacological properties, including treating diabetic encephalopathy and improving microcirculatory disorders. Saponins 35-42 reticulon 4 receptor Rattus norvegicus 20-24 30408535-15 2019 Treatment with saponin rich fraction of A. lebbeck increased levels of Caspases-3 (optical density of 0.24 at 450 nm) and Caspase-8 (optical density of 0.31 at 450 nm) as compared to staurosporine (optical density of 2.47 and 2.65 for caspases-3 and -8 respectively at 450 nm). Saponins 15-22 caspase 8 Homo sapiens 122-131 30502455-2 2019 Astragaloside IV (AIV) is a natural saponin abandent in Astragalus membranaceus and this study aims to find if AIV protects neuronal survival via preserving mitochondrial hexokinase-II (HK-II). Saponins 36-43 annexin A4 Mus musculus 18-21 30531436-0 2019 Panax Notoginseng Saponins Attenuate Myocardial Ischemia-Reperfusion Injury Through the HIF-1alpha/BNIP3 Pathway of Autophagy. Saponins 18-26 BCL2 interacting protein 3 Rattus norvegicus 99-104 30697065-0 2019 Erratum: Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells [Corrigendum]. Saponins 20-28 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 60-65 30697065-0 2019 Erratum: Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells [Corrigendum]. Saponins 20-28 BCL2 like 1 Homo sapiens 71-77 30634720-2 2019 Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng, and our previous studies showed the cardioprotective and neuroprotective effects of NGR1. Saponins 37-44 reticulon 4 receptor Mus musculus 20-24 30634720-2 2019 Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng, and our previous studies showed the cardioprotective and neuroprotective effects of NGR1. Saponins 37-44 reticulon 4 receptor Mus musculus 169-173 30463294-1 2018 Ginsenoside Rg1, a saponin that is a primary component of ginseng, has been demonstrated to protect hearts from diverse cardiovascular diseases with regulating multiple cellular signal pathways. Saponins 19-26 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 30989956-0 2019 [Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway]. Saponins 21-29 NLR family, pyrin domain containing 3 Rattus norvegicus 110-115 30989959-8 2019 The methodological results showed that GE,zingibroside R1,ginsenoside Ro and chikusetsu saponin IVa demonstrated a good linear relationship within the concentration ranges of 2-4 000,16-4 096,14-3 584,23-5 888 mug L-1 respectively. Saponins 88-95 ribosomal protein L4 Rattus norvegicus 214-217 30745871-0 2019 Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death. Saponins 39-46 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 65-69 29752696-0 2018 Total Saponins of Rubus Parvifolius L. Exhibited Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways. Saponins 6-14 signal transducer and activator of transcription 3 Mus musculus 86-91 29752696-0 2018 Total Saponins of Rubus Parvifolius L. Exhibited Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways. Saponins 6-14 eukaryotic translation initiation factor 4E Mus musculus 96-101 30532593-0 2018 Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells. Saponins 11-19 AKT serine/threonine kinase 1 Homo sapiens 46-49 30532593-0 2018 Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells. Saponins 11-19 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 51-56 30532593-0 2018 Securidaca-saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells. Saponins 11-19 BCL2 like 1 Homo sapiens 62-68 30593247-0 2018 [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-beta1/Smad3 signaling pathway in aging rats]. Saponins 11-19 transforming growth factor, beta 1 Rattus norvegicus 88-97 30450046-2 2018 Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and our previous studies have showed cardioprotective and neuroprotective effects of NGR1. Saponins 37-44 reticulon 4 receptor Rattus norvegicus 20-24 30450046-2 2018 Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and our previous studies have showed cardioprotective and neuroprotective effects of NGR1. Saponins 37-44 reticulon 4 receptor Rattus norvegicus 169-173 30264477-1 2018 Ginsenoside Rb2, a saponin from Panax ginseng, has been shown to have many functions. Saponins 19-26 RB transcriptional corepressor like 2 Mus musculus 12-15 30593247-0 2018 [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-beta1/Smad3 signaling pathway in aging rats]. Saponins 11-19 SMAD family member 3 Rattus norvegicus 98-103 30297638-1 2018 Capilliposide B (LC-B) and Capilliposide C (LC-C), two new triterpenoid saponins extracted from Lysimachia capillipes Hemsl, exhibit potential anticancer activity both in vitro and in vivo. Saponins 72-80 small nucleolar RNA, C/D box 118 Homo sapiens 44-48 30119231-1 2018 Araloside A is a triterpenoid saponin,which exhibits a broad spectrum of pharmacological activities, such as stimulating fibrinolysis, preventing coagulant, inhibiting renin, and decreasing blood pressure. Saponins 30-37 renin Homo sapiens 168-173 30039882-0 2018 NF-kappaB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice. Saponins 113-121 thymoma viral proto-oncogene 1 Mus musculus 24-27 29926388-5 2018 The apoptotic effects of saponins were further evaluated by annexin-V/propidium iodide dual staining experiment to examine the occurrence of phosphatidylserine externalization onto the cell surface by a flflow cytometer. Saponins 25-33 annexin A5 Homo sapiens 60-69 30320262-1 2018 Saponins are potential wide-spectrum antitumor drugs, and copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition is a suitable approach to synthesizing saponin-like compounds by regioselective glycosylation of the C2/C3 hydroxyl and C28 carboxylic groups of triterpene aglycones maslinic acid (MA) and oleanolic acid (OA). Saponins 0-8 complement C2 Homo sapiens 218-232 30320262-1 2018 Saponins are potential wide-spectrum antitumor drugs, and copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition is a suitable approach to synthesizing saponin-like compounds by regioselective glycosylation of the C2/C3 hydroxyl and C28 carboxylic groups of triterpene aglycones maslinic acid (MA) and oleanolic acid (OA). Saponins 156-163 complement C2 Homo sapiens 218-232 30413028-2 2018 Ginsenoside Rb1 (Rb1), an active saponin of Panax notoginseng, has been found to exert beneficial effects on inflammation and oxidative stress. Saponins 33-40 RB transcriptional corepressor 1 Mus musculus 12-15 30413028-2 2018 Ginsenoside Rb1 (Rb1), an active saponin of Panax notoginseng, has been found to exert beneficial effects on inflammation and oxidative stress. Saponins 33-40 RB transcriptional corepressor 1 Mus musculus 17-20 29908151-7 2018 In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response. Saponins 28-35 interferon gamma Mus musculus 183-192 29908151-7 2018 In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response. Saponins 28-35 interleukin 2 Mus musculus 194-198 29908151-7 2018 In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response. Saponins 28-35 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 211-217 29908151-7 2018 In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response. Saponins 28-35 immunoglobulin heavy variable V1-9 Mus musculus 226-231 29908469-10 2018 Among the six analytes, ginsenoside Rb1 showed slowest elimination from plasma with a t1/2z of 16.00 h, while that of the others were between 1.72 and 5.62 h. In conclusion, the developed method was successfully used to simultaneously analyze major oleanolic acid-type and damarane-type saponins of RPJ in rat plasma after oral administration. Saponins 287-295 RB transcriptional corepressor 1 Rattus norvegicus 36-39 30116354-3 2018 It was determined this steroidal saponin induced the apoptosis in Rh1 cells and activated caspase-3 and caspase-9. Saponins 33-40 caspase 3 Homo sapiens 90-99 30116354-3 2018 It was determined this steroidal saponin induced the apoptosis in Rh1 cells and activated caspase-3 and caspase-9. Saponins 33-40 caspase 9 Homo sapiens 104-113 29654431-1 2018 Saikosaponin a (SSa), a triterpenoid saponin, has numerous pharmacological properties, including anti-inflammatory and antioxidant effects. Saponins 5-12 tripartite motif-containing 21 Mus musculus 16-19 30235825-0 2018 Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-kappaB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways. Saponins 24-32 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 95-104 30235825-0 2018 Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-kappaB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways. Saponins 24-32 thymoma viral proto-oncogene 1 Mus musculus 136-139 29655658-2 2018 Saponins can induce either proinflammatory Th1/Th2 or sole anti-inflammatory Th2 immunities. Saponins 0-8 negative elongation factor complex member C/D Homo sapiens 43-46 29782965-0 2018 Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin. Saponins 77-92 Rh associated glycoprotein Homo sapiens 70-73 29782965-11 2018 This work is the first reporting that membrane cholesterol could delay the activity of ginsenoside Rh2, renewing the idea that saponin cytotoxicity is ascribed to an interaction with membrane cholesterol. Saponins 127-134 Rh associated glycoprotein Homo sapiens 99-102 29528145-4 2018 Here, we report that Timosaponin A-III (TA-III), a steroidal saponin obtained from the rhizomes of an herb, Anemarrhena asphodeloides, strongly inhibits expression of BMI1 in breast cancer cells. Saponins 25-32 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 167-171 29954059-1 2018 Ginsenosides Rg1 is one of the major pharmacologically active saponins in ginseng, which as an antioxidant reduces oxidative damage in the liver and can also be used to prevent cardiovascular diseases and diabetes. Saponins 62-70 protein phosphatase 1, regulatory subunit 3A Mus musculus 13-16 29765072-3 2018 Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects. Saponins 37-44 reticulon 4 receptor Mus musculus 20-24 30128881-0 2018 Saponin from Tupistra chinensis Bak Inhibits NF-kappaB Signaling in Sarcoma S-180 Cell Mouse Xenografts. Saponins 0-7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-54 29501622-0 2018 Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats. Saponins 22-30 RB transcriptional corepressor 1 Rattus norvegicus 31-34 29501622-0 2018 Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats. Saponins 22-30 AKT serine/threonine kinase 1 Rattus norvegicus 64-67 29501622-0 2018 Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats. Saponins 22-30 mechanistic target of rapamycin kinase Rattus norvegicus 69-73 29501622-0 2018 Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats. Saponins 22-30 phosphatase and tensin homolog Rattus norvegicus 74-78 29706292-3 2018 Therefore, the ability of a novel saponin-based adjuvant G3 to inducing balanced Th1 and Th2 responses in BALB/c mice immunized with a split trivalent seasonal influenza vaccine was evaluated in comparison to that of the adjuvant Al(OH)3. Saponins 34-41 negative elongation factor complex member C/D, Th1l Mus musculus 81-84 29377384-0 2018 Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Saponins 6-13 AKT serine/threonine kinase 1 Homo sapiens 72-75 29377384-0 2018 Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Saponins 6-13 ATP binding cassette subfamily B member 1 Homo sapiens 107-121 29849908-6 2018 In aggregate, DKSM and PSRE attenuated the hypercholesterolemia-associated oxidative stress and systemic inflammation in rats, potentially by enhancement of hepatic endogenous antioxidant defense via activation of the Nrf2-ARE pathway, which may be contributed by the rich content of phenolics and saponins in DKSM and PSRE. Saponins 298-306 NFE2 like bZIP transcription factor 2 Rattus norvegicus 218-222 29625607-6 2018 RESULTS: AEAC containing flavonoids, phenols, saponins and protodioscin induced enhancement of NGF secretion and decreased intracellular ROS in the neuronal and microglial cell line. Saponins 46-54 nerve growth factor Mus musculus 95-98 29655658-4 2018 While saponins having different triterpenoid aglycons and oligosaccharide chains can activate DCs to induce Th1/Th2 immunoresponses, fucopyranosyl residues from their oligosaccharides by binding to the DC-SIGN receptor can bias DCs toward a sole Th2 immunity. Saponins 6-14 negative elongation factor complex member C/D Homo sapiens 108-111 29471392-4 2018 The 50% hemolytic dosage (HD50) value of tea seed saponins was increased from 6.69 to 27.43 mug mL-1. Saponins 50-58 L1 cell adhesion molecule Mus musculus 96-100 29280337-7 2018 The results suggest that notoginsenoside Fc and ginsenoside Rb3 showed relatively higher exposure compared with other saponins. Saponins 118-126 stathmin 4 Rattus norvegicus 60-63 29584740-9 2018 RESULTS: The addition of Panax quinquefolius saponins (PQS+DAPT) to standard DAPT therapy significantly decreased the myocardial infarct area, degree of myocardial lesions, TXB2 and PAI levels, and the TXB2/6-keto-PGF1alpha ratio, while increasing 6-keto-PGF1alpha and t-PA levels and reducing the degree of gastric mucosal injury. Saponins 45-53 serpin family E member 1 Rattus norvegicus 182-185 29599776-3 2018 The Leishmania amastigote 2 (A2) protein has been repeatedly described as immunogenic and protective against VL in different animal models; it is recognized by human T cells, and it is also commercially available in a vaccine formulation containing saponin against canine VL. Saponins 249-256 UDP glucuronosyltransferase 1 family, polypeptide A7C Rattus norvegicus 29-31 29692648-1 2018 Objective: To study the effects of the different components of the total flavonoids and total saponins from Mao Dongqing"s active site on the rats of TIA model, determine the optimal reactive components ratio of Mao Dongqing on the rats of TIA. Saponins 94-102 monoamine oxidase A Rattus norvegicus 108-111 29425748-2 2018 Ginsenoside Rb2 (Rb2) is the most abundant saponin in Panax ginseng, this study investigates the role of Rb2 in the anti-hyperglycemic mechanism of insulin-sensitive cell lines 3T3-L1 adipocytes as well as high fat diet-induced obesity mice. Saponins 43-50 RB transcriptional corepressor like 2 Mus musculus 12-15 29425748-2 2018 Ginsenoside Rb2 (Rb2) is the most abundant saponin in Panax ginseng, this study investigates the role of Rb2 in the anti-hyperglycemic mechanism of insulin-sensitive cell lines 3T3-L1 adipocytes as well as high fat diet-induced obesity mice. Saponins 43-50 RB transcriptional corepressor like 2 Mus musculus 17-20 29425748-2 2018 Ginsenoside Rb2 (Rb2) is the most abundant saponin in Panax ginseng, this study investigates the role of Rb2 in the anti-hyperglycemic mechanism of insulin-sensitive cell lines 3T3-L1 adipocytes as well as high fat diet-induced obesity mice. Saponins 43-50 RB transcriptional corepressor like 2 Mus musculus 17-20 29692648-4 2018 Results: The contents of total flavonoids and total saponins in the active part of Mao Dongqing can significantly improve the pathological changes of brain tissue in rats, improve the activity of Na+-K+-ATP enzyme, Ca++-ATP enzyme and Mg++-ATP enzyme in the brain of rats, and reduce the level of glutamic acid in serum. Saponins 52-60 monoamine oxidase A Rattus norvegicus 83-86 29692648-6 2018 CONCLUSION: The different proportions of total flavonoids and total saponins in the active part of Mao Dongqing all has a better effect on the rats with TIA, and the ratio of 10:6 is the best active component for preventing and controlling TIA. Saponins 68-76 monoamine oxidase A Rattus norvegicus 99-102 29355315-7 2018 These findings demonstrated for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppressed GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells. Saponins 95-102 solute carrier family 2 member 2 Homo sapiens 129-134 29355315-7 2018 These findings demonstrated for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppressed GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells. Saponins 95-102 solute carrier family 10 member 2 Homo sapiens 183-187 29355315-7 2018 These findings demonstrated for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppressed GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells. Saponins 95-102 ATP binding cassette subfamily C member 2 Homo sapiens 195-199 29225132-2 2018 The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Saponins 34-41 Rh blood group D antigen Homo sapiens 16-19 29225132-2 2018 The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Saponins 34-41 Rh blood group D antigen Homo sapiens 21-24 29225132-2 2018 The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Saponins 118-126 Rh blood group D antigen Homo sapiens 16-19 29225132-2 2018 The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Saponins 118-126 Rh blood group D antigen Homo sapiens 21-24 29455728-3 2018 Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%- 64.6% at 50 mumol L-1, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC50 values being 12.7 and 8.3 mumol L-1, respectively. Saponins 14-21 homeobox B7 Homo sapiens 206-219 29247773-2 2018 Saponins and sapogenins are considered as valuable natural products for ameliorating this pathology, possibly through the nuclear receptor PPARgamma activation. Saponins 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 139-148 28558522-0 2018 Saponin Extracts Induced Apoptosis of Endometrial Cells From Women With Endometriosis Through Modulation of miR-21-5p. Saponins 0-7 microRNA 215 Homo sapiens 108-117 28558522-6 2018 After the saponin extract treatment, the expression of caspase 3 was significantly increased in HESCs. Saponins 10-17 caspase 3 Homo sapiens 55-64 28558522-11 2018 In conclusions, treatment with saponin extracts significantly decreased the expression of miR-21-5p in HESCs from patients with endometriosis. Saponins 31-38 microRNA 215 Homo sapiens 90-99 29301342-7 2018 The rSMP-3/saponin combination induced high production of protein-specific IFN-gamma, IL-12, and granulocyte-macrophage colony-stimulating factor (GM-CSF) by the spleen cells of the immunized mice. Saponins 11-18 interferon gamma Mus musculus 75-84 29287199-0 2018 Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway. Saponins 27-34 Ras homolog, mTORC1 binding Rattus norvegicus 138-142 29287199-0 2018 Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway. Saponins 27-34 mechanistic target of rapamycin kinase Rattus norvegicus 143-147 29287199-5 2018 Upon the intervention of Trillium tschonoskii Maxim (TTM) saponin, one of bioactive components from local natural herbs in China, the learning and memory capacity of D-gal-induced aging rats was evaluated through Morris water maze test, and the regulation of Rheb-mTOR signal pathway and functional status of autophagy in hippocampal tissues of D-gal-induced aging rats was explored by Western blot. Saponins 58-65 Ras homolog, mTORC1 binding Rattus norvegicus 259-263 29287199-5 2018 Upon the intervention of Trillium tschonoskii Maxim (TTM) saponin, one of bioactive components from local natural herbs in China, the learning and memory capacity of D-gal-induced aging rats was evaluated through Morris water maze test, and the regulation of Rheb-mTOR signal pathway and functional status of autophagy in hippocampal tissues of D-gal-induced aging rats was explored by Western blot. Saponins 58-65 mechanistic target of rapamycin kinase Rattus norvegicus 264-268 29287199-6 2018 TTM saponin revealed an obvious function to improve learning and memory capacity of D-gal-induced aging rats through up-regulating Rheb and down-regulating mTOR, thereby rescuing dysfunctional autophagy to execute anti-aging role. Saponins 4-11 Ras homolog, mTORC1 binding Rattus norvegicus 131-135 29287199-6 2018 TTM saponin revealed an obvious function to improve learning and memory capacity of D-gal-induced aging rats through up-regulating Rheb and down-regulating mTOR, thereby rescuing dysfunctional autophagy to execute anti-aging role. Saponins 4-11 mechanistic target of rapamycin kinase Rattus norvegicus 156-160 28993280-2 2018 Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-activated protein kinase (AMPK). Saponins 48-56 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 146-174 28993280-2 2018 Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-activated protein kinase (AMPK). Saponins 48-56 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 176-180 29301342-7 2018 The rSMP-3/saponin combination induced high production of protein-specific IFN-gamma, IL-12, and granulocyte-macrophage colony-stimulating factor (GM-CSF) by the spleen cells of the immunized mice. Saponins 11-18 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 97-145 29301342-7 2018 The rSMP-3/saponin combination induced high production of protein-specific IFN-gamma, IL-12, and granulocyte-macrophage colony-stimulating factor (GM-CSF) by the spleen cells of the immunized mice. Saponins 11-18 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 147-153 29207398-1 2018 OBJECTIVE: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin. Saponins 90-97 RB transcriptional corepressor 1 Rattus norvegicus 25-28 29425646-9 2018 Thirteen saponins out of the nineteen tested increased IL-1beta concentrations considerably, while six compounds changed IL-2 or IFN-gamma levels slightly. Saponins 9-17 interleukin 1 beta Homo sapiens 55-63 29425646-11 2018 CONCLUSION: In this study, almost all saponins with oleanolic acid as aglycones exhibited significant hemolysis, monodesmosidic saponins with hederagenin as aglycone were the most active compounds against lung cancer cells with greater activity than standard commercial chemotherapy drug doxorubicin and some of the hederagenin type saponins induced remarkable IL-1beta secretion. Saponins 38-46 interleukin 1 beta Homo sapiens 361-369 29318977-0 2018 Inhibition of Migration and Invasion of Hepatocarcinoma HepG2 Cells by Dietary Saponins via Targeting HIF-1alpha. Saponins 79-87 hypoxia inducible factor 1 subunit alpha Homo sapiens 102-112 29318977-5 2018 Under the same simulated hypoxia, the molecular mechanism of saponin function was conducted by measuring the gene expression of Hypoxia Inducible Factor (HIF)-1alpha through RT-PCR, in which ZC-3 showed a potent inhibition of gene HIF-1alpha. Saponins 61-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 128-165 29318977-5 2018 Under the same simulated hypoxia, the molecular mechanism of saponin function was conducted by measuring the gene expression of Hypoxia Inducible Factor (HIF)-1alpha through RT-PCR, in which ZC-3 showed a potent inhibition of gene HIF-1alpha. Saponins 61-68 misshapen like kinase 1 Homo sapiens 191-195 29318977-5 2018 Under the same simulated hypoxia, the molecular mechanism of saponin function was conducted by measuring the gene expression of Hypoxia Inducible Factor (HIF)-1alpha through RT-PCR, in which ZC-3 showed a potent inhibition of gene HIF-1alpha. Saponins 61-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 231-241 29318977-6 2018 For the protein expression by immunofluorescence staining with confocal microscopy, HIF-1alpha was also inhibited by saponins, with the most potent one being ZC-4 after eight hours" relatively hypoxia incubation. Saponins 117-125 hypoxia inducible factor 1 subunit alpha Homo sapiens 84-94 29318977-7 2018 CONCLUSION: Saponins ZC-4 and ZC-3 have the potential to reduce HepG2 cell proliferation, migration and invasion caused by hypoxia through effectively inhibiting the gene and protein expression of HIF-1alpha directly and as antioxidant indirectly. Saponins 12-20 hypoxia inducible factor 1 subunit alpha Homo sapiens 197-207 29061506-3 2018 Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Saponins 47-54 heat shock protein 86, pseudogene 1 Mus musculus 127-132 29169044-1 2018 Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, is reported as a potent suppressor of pro-inflammatory functions of macrophages. Saponins 25-32 flotillin 2 Mus musculus 17-20 29203451-9 2018 RESULTS: An increased CPRG substrate concentration combined with a different detergent, Saponin, and an optimal wavelength recording markedly increased the sensitivity for the detection of beta-galactosidase activity ( 4-fold increase). Saponins 88-95 galactosidase beta 1 Homo sapiens 189-207 29207398-1 2018 OBJECTIVE: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin. Saponins 90-97 stathmin 4 Rattus norvegicus 33-36 28278662-6 2017 After eight days of fermentation, the total saponins produced in the culture broth of PN8 and PN17 were 1.061 and 0.583 mg mL-1, respectively. Saponins 44-52 L1 cell adhesion molecule Mus musculus 123-127 29276182-6 2017 RESULTS: Our results indicated a significant increase in the expression of IFN-gamma, IL-10 and IL-13, but not IL-12A, gene transcripts in PBMCs of FML-saponin vaccinated dogs in comparison with controls. Saponins 152-159 interferon gamma Canis lupus familiaris 75-84 29276182-6 2017 RESULTS: Our results indicated a significant increase in the expression of IFN-gamma, IL-10 and IL-13, but not IL-12A, gene transcripts in PBMCs of FML-saponin vaccinated dogs in comparison with controls. Saponins 152-159 interleukin 10 Canis lupus familiaris 86-91 29276182-6 2017 RESULTS: Our results indicated a significant increase in the expression of IFN-gamma, IL-10 and IL-13, but not IL-12A, gene transcripts in PBMCs of FML-saponin vaccinated dogs in comparison with controls. Saponins 152-159 interleukin 13 Canis lupus familiaris 96-101 29276182-7 2017 Our findings showed a significant difference in the ratio of IFN-gamma/IL-10 mRNA expression in FML-saponin vaccinated dogs in comparison with two control groups. Saponins 100-107 interferon gamma Canis lupus familiaris 61-70 29276182-7 2017 Our findings showed a significant difference in the ratio of IFN-gamma/IL-10 mRNA expression in FML-saponin vaccinated dogs in comparison with two control groups. Saponins 100-107 interleukin 10 Canis lupus familiaris 71-76 29104273-1 2017 In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ). Saponins 139-147 monoamine oxidase A Rattus norvegicus 190-193 29104273-13 2017 Compared with monomer administration group, the intestinal absorption of C3, C4, DC1, and DC2 was significantly improved by co-existing components in MDQ-TS, and the non-absorbable saponins of C4, DC1, and DC2 unexpectedly showed sufficient intestinal permeability with Papp > 0.12 x 10-2 cm min-1. Saponins 181-189 oligosaccharyltransferase complex non-catalytic subunit Rattus norvegicus 90-93 29039503-0 2017 Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1beta and high-mobility group box 1 release in macrophages. Saponins 47-55 tumor necrosis factor Mus musculus 132-141 29039503-0 2017 Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1beta and high-mobility group box 1 release in macrophages. Saponins 47-55 interleukin 1 beta Mus musculus 143-151 29039503-8 2017 The results demonstrated that these five saponins significantly suppressed LPS-induced expression of TNF-alpha and IL-1beta at the mRNA and protein level in RAW264.7 cells. Saponins 41-49 tumor necrosis factor Mus musculus 101-110 29039503-8 2017 The results demonstrated that these five saponins significantly suppressed LPS-induced expression of TNF-alpha and IL-1beta at the mRNA and protein level in RAW264.7 cells. Saponins 41-49 interleukin 1 beta Mus musculus 115-123 29039503-10 2017 Taken together, these results suggested that the anti-inflammatory activity of AGS-derived saponins may be associated with the downregulation of TNF-alpha and IL-1beta, and the "late-phase" proinflammatory cytokine HMGB1, via negative regulation of the NF-kappaB pathway in RAW264.7 cells. Saponins 91-99 tumor necrosis factor Mus musculus 145-154 29039503-10 2017 Taken together, these results suggested that the anti-inflammatory activity of AGS-derived saponins may be associated with the downregulation of TNF-alpha and IL-1beta, and the "late-phase" proinflammatory cytokine HMGB1, via negative regulation of the NF-kappaB pathway in RAW264.7 cells. Saponins 91-99 interleukin 1 beta Mus musculus 159-167 28278662-7 2017 The saponin extracts exhibited moderate to high (inhibition zone diameter 15.7-28.4 mm, MIC 1.6-12.5 mg mL-1) antimicrobial activity against pathogens tested. Saponins 4-11 L1 cell adhesion molecule Mus musculus 104-108 29262539-0 2017 Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1alpha. Saponins 18-26 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 95-105 29376267-0 2017 [Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-kappaB signaling pathway in aging rats]. Saponins 11-19 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 92-96 29376267-0 2017 [Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-kappaB signaling pathway in aging rats]. Saponins 11-19 sirtuin 1 Rattus norvegicus 97-102 28849171-3 2017 Ginsenoside Rg1 (Rg1) is a steroidal saponin found in ginseng. Saponins 37-44 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 28849171-3 2017 Ginsenoside Rg1 (Rg1) is a steroidal saponin found in ginseng. Saponins 37-44 protein phosphatase 1, regulatory subunit 3A Mus musculus 17-20 29263880-2 2017 Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4"-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01. Saponins 143-150 toll like receptor 4 Homo sapiens 79-83 29263880-2 2017 Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4"-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01. Saponins 143-150 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 92-129 29263880-2 2017 Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4"-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01. Saponins 143-150 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 131-134 28397101-2 2017 To identify extended-spectrum beta-lactamases (ESBL) directly in positive blood culture bottles, we developed a workflow of saponin extraction followed by a bottom-up proteomics approach using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Saponins 124-131 EsbL Escherichia coli 47-51 28711525-2 2017 In this study, platycodin D (PD), a saponin isolated from traditional Chinese herb Platycodonis Radix, was identified as a novel Hsp90 inhibitor. Saponins 36-43 heat shock protein 90 alpha family class A member 1 Homo sapiens 129-134 29192437-6 2017 In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food. Saponins 110-118 RELA proto-oncogene, NF-kB subunit Homo sapiens 138-141 29192437-6 2017 In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food. Saponins 110-118 nuclear factor kappa B subunit 1 Homo sapiens 192-201 28844006-6 2017 In addition, cell extraction experiments performed using Triton X-100 and saponin showed that a pool of tau45-230 was associated with the cytoskeleton and the cytoskeleton plus membrane-bound organelles, respectively, in cultured hippocampal neurons. Saponins 74-81 ATP binding cassette subfamily A member 1 Homo sapiens 177-191 28953944-4 2017 Here, we investigated whether a currently licensed commercial subunit rA2 protein-saponin vaccine (Leish-tec ) had an additional effect to dog culling on reducing the canine infectious populations. Saponins 82-89 UDP glucuronosyltransferase 1 family, polypeptide A7C Rattus norvegicus 70-73 29109794-3 2017 Ginsenoside Rg1 is a major propanaxatriol-type saponin in ginseng. Saponins 47-54 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 28547925-0 2017 The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis. Saponins 4-11 myosin, heavy polypeptide 9, non-muscle Mus musculus 39-74 28547925-0 2017 The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis. Saponins 4-11 tumor necrosis factor receptor superfamily, member 1b Mus musculus 80-94 28547925-0 2017 The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis. Saponins 4-11 coagulation factor III Mus musculus 108-121 28547925-3 2017 Here, we have shown that a natural saponin, D39, from Liriope muscari exerted anti-thrombotic activity in vivo, by targeting NMMHC IIA. Saponins 35-42 myosin, heavy polypeptide 9, non-muscle Mus musculus 125-134 28414111-6 2017 Brij 35, Tween 20, saponin and digitonin selectively extracted IGF2R compared to other two receptors. Saponins 19-26 insulin like growth factor 2 receptor Homo sapiens 63-68 28633386-6 2017 The results showed that administration of tea saponins significantly increased total antioxidant capacity, total superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and alpha-tocopherol, and decreased malondialdehyde and protein carbonyl. Saponins 46-54 catalase Gallus gallus 135-143 32188210-7 2017 Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including HepG3B, Huh-7 and plc/prf/5 cells. Saponins 89-96 EHHADH antisense RNA 1 Homo sapiens 225-235 27640876-1 2017 Ginsenoside Rb1, the major saponin component of ginseng root, has a wide range of therapeutic application. Saponins 27-34 RB transcriptional corepressor 1 Mus musculus 12-15 32188210-7 2017 Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including HepG3B, Huh-7 and plc/prf/5 cells. Saponins 89-96 MIR7-3 host gene Homo sapiens 289-294 28737726-1 2017 Compound K is one of the active metabolites of Panaxnotoginseng saponins, which could attenuate the formation of atherosclerosis in mice modelsvia activating LXRalpha. Saponins 64-72 nuclear receptor subfamily 1, group H, member 3 Mus musculus 158-166 28716103-10 2017 The effect of saponins from fruit, bark and leaves (Zf.Sa, Zb.Sa and Zl.Sa) against Caco-2 cell lines inhibited the growth of Caco-2 by 53.16 (+-3.31) %, 66.43 (+- 3.24) and 45.96 (+- 10.67) respectively with respect to Actinomycin-D (4 muM) which showed the growth inhibition of 65.40(+-4.29) %. Saponins 14-22 latexin Homo sapiens 237-240 28579031-8 2017 The action of saponins on glycoprotein pump (Pgp) activity in L3 larvae was compared to that of the pump blocker Verapamil (VPL). Saponins 14-22 phosphoglycolate phosphatase Mus musculus 45-48 28539361-4 2017 Membrane permeabilization of cardiac myocytes with saponin and/or Triton X-100 increased NAADP synthesis, indicating that intracellular CD38 contributes to NAADP production. Saponins 51-58 CD38 antigen Mus musculus 136-140 28729651-5 2017 Combination of ginsenoside Rb1 and Rd, two major saponin compounds of PNS, recapitulated the retinal protection of PNS and attenuated retinal oxidative stress and inflammatory changes. Saponins 49-56 RB transcriptional corepressor 1 Mus musculus 27-30 28456576-0 2017 Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis. Saponins 23-30 toll-like receptor 2 Rattus norvegicus 75-79 28478866-6 2017 Isolated saponins (1-4) and six previously reported saponins (5-10) were tested for their inhibitory effects of Abeta aggregation and their protective effects on SH-SY5Y cells against Abeta-associated toxicity. Saponins 9-17 amyloid beta precursor protein Homo sapiens 112-117 28579930-4 2017 RESULTS: PD known as a saponin with four sugar moieties, an inhibitor for platelet aggregation, and a low density lipoprotein (LPL) lowering agent, displayed strong growth inhibitory effect to HL-60. Saponins 23-30 lipoprotein lipase Homo sapiens 127-130 28327531-3 2017 The toll-like receptor ligand Poly I:C and the saponin Quil A polarized swine DC cytokines towards a type 1 phenotype, with preferential production of IL-12 and TNF-alpha. Saponins 47-54 tumor necrosis factor Sus scrofa 163-172 28587113-8 2017 On the other hand, many herbal antagonists of c-Met-dependent signaling, such as saponin, resveratrol, and LZ-8, were identified. Saponins 81-88 MET proto-oncogene, receptor tyrosine kinase Homo sapiens 46-51 28235471-0 2017 Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells. Saponins 51-58 CD19 molecule Homo sapiens 120-124 28273565-2 2017 The cell viability assays indicate that synthetic saponins show antiproliferation activities in three cancer cell lines with IC50 values of 2.4-15.1 muM and hederacolchiside A1 being the most potent. Saponins 50-58 latexin Homo sapiens 149-152 28373842-0 2017 Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt beta-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Saponins 70-77 catenin beta 1 Homo sapiens 109-121 28373842-0 2017 Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt beta-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Saponins 70-77 secreted frizzled related protein 4 Homo sapiens 155-190 28701874-1 2017 BACKGROUND: Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. Saponins 49-56 Rh associated glycoprotein Homo sapiens 24-27 28701874-1 2017 BACKGROUND: Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. Saponins 49-56 Rh associated glycoprotein Homo sapiens 31-34 28216107-4 2017 Here, we show that the disruption of the phosphatidic acid phosphatase-encoding PAH1 through CRISPR/Cas9 results in a dramatic expansion of the endoplasmic reticulum (ER), which stimulated the production of recombinant triterpene biosynthesis enzymes and ultimately boosted triterpenoid and triterpene saponin accumulation. Saponins 302-309 phosphatidate phosphatase PAH1 Saccharomyces cerevisiae S288C 80-84 27825116-3 2017 Here we show for the first time, with mechanism-based evidence, that ginsenoside-Rb1, a natural saponin isolated from the rhizome of Panax quinquefolius and notoginseng, exhibits potent cytotoxicity on CSCs. Saponins 96-103 RB transcriptional corepressor 1 Homo sapiens 81-84 28017695-0 2017 miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis. Saponins 76-84 microRNA 29c Mus musculus 0-7 28109786-1 2017 During the search for protein tyrosine phosphatase 1B (PTP1B) inhibitors from marine organisms, the known tetramic acid derivative, melophlin C (1), was isolated as an active component together with the new nortriterpenoid saponin, sarasinoside S (2), and three homologues: sarasinosides A1 (3), I1 (4), and J (5), from the Indonesian marine sponge Petrosia sp. Saponins 223-230 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 55-60 26712031-4 2017 METHODS: Here we present in vivo studies highlighting a protective function of ginsenoside Rb1, a natural steroid glycoside derivative purified from saponin of Panax ginseng, in neurological injury during aging. Saponins 149-156 RB transcriptional corepressor 1 Homo sapiens 91-94 28049560-6 2017 In the results, the administration of the recombinant protein plus saponin induced a specific IFN-gamma, IL-12 and GM-CSF production, as well as high IgG2a isotype antibody levels, which protected mice against a challenge using L. amazonensis promastigotes. Saponins 67-74 interferon gamma Mus musculus 94-103 28049560-6 2017 In the results, the administration of the recombinant protein plus saponin induced a specific IFN-gamma, IL-12 and GM-CSF production, as well as high IgG2a isotype antibody levels, which protected mice against a challenge using L. amazonensis promastigotes. Saponins 67-74 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 115-121 28049560-6 2017 In the results, the administration of the recombinant protein plus saponin induced a specific IFN-gamma, IL-12 and GM-CSF production, as well as high IgG2a isotype antibody levels, which protected mice against a challenge using L. amazonensis promastigotes. Saponins 67-74 immunoglobulin heavy variable V1-9 Mus musculus 150-155 28137413-0 2017 Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1beta-induced inflammation and apoptosis in vitro. Saponins 22-30 interleukin 1 beta Rattus norvegicus 74-91 27593711-3 2017 The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-gamma, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses. Saponins 28-35 RAB11 family interacting protein 1 (class I) Mus musculus 24-27 27828760-0 2017 Ginseng Stem-and-Leaf Saponin (GSLS)-Enhanced Protective Immune Responses Induced by Toxoplasma gondii Heat Shocked Protein 70 (HSP70) Against Toxoplasmosis in Mice. Saponins 22-29 heat shock protein 1B Mus musculus 128-133 27912969-5 2017 Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. Saponins 19-27 nitric oxide synthase 2, inducible Mus musculus 169-190 27912969-5 2017 Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. Saponins 19-27 nitric oxide synthase 2, inducible Mus musculus 192-196 27912969-5 2017 Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. Saponins 19-27 prostaglandin-endoperoxide synthase 2 Mus musculus 202-218 27912969-5 2017 Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. Saponins 19-27 prostaglandin-endoperoxide synthase 2 Mus musculus 220-225 27123551-3 2017 Saikosaponin A (SSA) is a triterpenoid saponin isolated from Radix Bupleuri. Saponins 5-12 tripartite motif containing 21 Homo sapiens 16-19 30650272-20 2017 01) , expressions levels of Bax, Caspase-3, and pAPP were down-regulated, Bcl-2/Bax ratio was obviously elevated in the saponin group, the volatile oil group, the polysaccharide group (P <0. Saponins 120-127 BCL2, apoptosis regulator Rattus norvegicus 74-79 30650272-20 2017 01) , expressions levels of Bax, Caspase-3, and pAPP were down-regulated, Bcl-2/Bax ratio was obviously elevated in the saponin group, the volatile oil group, the polysaccharide group (P <0. Saponins 120-127 BCL2 associated X, apoptosis regulator Rattus norvegicus 80-83 28112228-0 2017 Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Saponins 31-39 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 28112228-0 2017 Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Saponins 31-39 mechanistic target of rapamycin kinase Danio rerio 109-113 28112228-0 2017 Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Saponins 31-39 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 118-122 28112228-0 2017 Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Saponins 31-39 sirtuin 1 Danio rerio 123-128 28112228-0 2017 Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Saponins 31-39 forkhead box O3 Rattus norvegicus 129-134 28088315-0 2017 Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway. Saponins 6-13 AKT serine/threonine kinase 1 Homo sapiens 78-81 28088315-0 2017 Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway. Saponins 6-13 mechanistic target of rapamycin kinase Homo sapiens 82-86 27903977-3 2017 Our preliminary data showed that dioscin, a glucoside saponin, could upregulate the expression of connexins Cx26 and Cx43, major components of gap junctions, in melanoma cells. Saponins 54-61 gap junction protein, beta 2 Mus musculus 108-112 27903977-3 2017 Our preliminary data showed that dioscin, a glucoside saponin, could upregulate the expression of connexins Cx26 and Cx43, major components of gap junctions, in melanoma cells. Saponins 54-61 gap junction protein, alpha 1 Mus musculus 117-121 28250796-2 2017 Our previous study has shown that Panax notoginseng saponins (PNS) have an antiaging action by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of aged rats. Saponins 52-60 catalase Mus musculus 158-161 28496480-7 2017 In addition, the crude saponin increased sub-G1 peak in flow cytometry histogram of treated cells, ROS generation and caspase-3 and -9 activity (IC50 of 11.10, 11.27 microg/mL). Saponins 23-30 caspase 3 Homo sapiens 118-134 28496480-8 2017 The dose dependent down regulation of Bcl-2 in treated cells demonstrated that saponin fraction can trigger intrinsic apoptotic pathway in cancer cells. Saponins 79-86 BCL2 apoptosis regulator Homo sapiens 38-43 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 cyclin dependent kinase inhibitor 3 Homo sapiens 108-141 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 cyclin dependent kinase inhibitor 3 Homo sapiens 143-147 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 cyclin dependent kinase inhibitor 1A Homo sapiens 149-152 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 cyclin dependent kinase inhibitor 1A Homo sapiens 153-157 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 microRNA 34a Homo sapiens 194-200 27388719-1 2017 Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. Saponins 37-44 microRNA 21 Homo sapiens 205-211 27553977-0 2016 Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells. Saponins 6-14 vascular endothelial growth factor c Danio rerio 76-82 27566197-0 2016 Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. Saponins 18-26 microRNA 222 Mus musculus 100-107 27780139-2 2016 Platycodin D (PLD), a triterpenoid saponin isolated from the root of Platycodon grandiflorum, has anti-inflammatory effects in a mouse model of allergic asthma. Saponins 35-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 27598942-0 2016 Protective effect of Trillium tschonoskii saponin on CCl4-induced acute liver injury of rats through apoptosis inhibition. Saponins 42-49 C-C motif chemokine ligand 4 Rattus norvegicus 53-57 26712211-0 2016 Panax notoginseng saponins protect kidney from diabetes by up-regulating silent information regulator 1 and activating antioxidant proteins in rats. Saponins 18-26 sirtuin 1 Rattus norvegicus 73-103 27593711-3 2017 The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-gamma, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses. Saponins 28-35 interferon gamma Mus musculus 109-118 27593711-3 2017 The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-gamma, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses. Saponins 28-35 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 130-136 27593711-3 2017 The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-gamma, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses. Saponins 28-35 interleukin 4 Mus musculus 209-213 27593711-3 2017 The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-gamma, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses. Saponins 28-35 interleukin 10 Mus musculus 218-223 27282665-0 2016 Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-beta1/Smads signaling pathway modulation. Saponins 60-68 transforming growth factor, beta 1 Rattus norvegicus 95-104 27693742-0 2016 A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways. Saponins 16-23 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 149-157 27482746-7 2016 In addition, TT saponins resulted in a further significant increase in AR in gastrocnemius and significantly suppressed the overtraining-induced increase in IGF-1R in the liver. Saponins 16-24 androgen receptor Rattus norvegicus 71-73 27482746-7 2016 In addition, TT saponins resulted in a further significant increase in AR in gastrocnemius and significantly suppressed the overtraining-induced increase in IGF-1R in the liver. Saponins 16-24 insulin-like growth factor 1 receptor Rattus norvegicus 157-163 27482746-8 2016 These results indicated that TT saponins increased performance, body mass, and gastrocnemius mass of rats undergoing overtraining, which might be attributed to the changes in androgen-AR axis and IGF-1R signaling. Saponins 32-40 androgen receptor Rattus norvegicus 184-186 27482746-8 2016 These results indicated that TT saponins increased performance, body mass, and gastrocnemius mass of rats undergoing overtraining, which might be attributed to the changes in androgen-AR axis and IGF-1R signaling. Saponins 32-40 insulin-like growth factor 1 receptor Rattus norvegicus 196-202 27420349-0 2016 Triterpenoid Saponins from the Caryophyllaceae Family Modulate the Efflux Activity of the P-Glycoprotein in an In Vitro Model of Intestinal Barrier. Saponins 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 90-104 27420349-3 2016 In this context, the role of saponins on the intestinal permeability of a P-glycoprotein substrate was investigated. Saponins 29-37 ATP binding cassette subfamily B member 1 Homo sapiens 74-88 27420349-4 2016 The P-glycoprotein inhibition activity of three triterpenoid saponins extracted from several plants of the Caryophyllaceae family was evaluated using an intestinal barrier model comprised of Caco-2 cell lines. Saponins 61-69 ATP binding cassette subfamily B member 1 Homo sapiens 4-18 27420349-5 2016 The results showed a strong effect of two saponins on P-glycoprotein-mediated transport. Saponins 42-50 ATP binding cassette subfamily B member 1 Homo sapiens 54-68 27420349-6 2016 At a concentration of 15 microM, the efflux ratio was close to 1 for both saponins, thus suggesting a total inhibition of the efflux pump in contrast to verapamil HCl, a conventional P-glycoprotein inhibitor. Saponins 74-82 ATP binding cassette subfamily B member 1 Homo sapiens 183-197 27332950-0 2016 Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways. Saponins 11-18 sirtuin 1 Homo sapiens 107-112 27332950-0 2016 Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways. Saponins 11-18 PPARG coactivator 1 alpha Homo sapiens 113-123 27332950-0 2016 Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways. Saponins 11-18 superoxide dismutase 2 Homo sapiens 124-130 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 occludin Rattus norvegicus 94-102 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 NFE2 like bZIP transcription factor 2 Rattus norvegicus 108-112 27177748-1 2016 Ginsenoside Rh2, a triterpene saponin extracted from Panax ginseng, exhibits pharmacological activity against multiple cancers. Saponins 30-37 Rh associated glycoprotein Homo sapiens 12-15 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 heme oxygenase 1 Rattus norvegicus 113-117 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 118-123 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 sirtuin 1 Rattus norvegicus 124-129 30209929-6 2016 Compared with aging model rats,total saponins of Panax japonicus increased the expressions of Occludin,ZO-1,Nrf2,HO-1,NQO-1,Sirt1 and PGC-1alpha( P < 0. Saponins 37-45 PPARG coactivator 1 alpha Rattus norvegicus 134-144 27295967-2 2016 The ginsenoside Rb1 magnetic molecular imprinted polymers (Rb1-MMIPs) were successfully synthesized for specific recognition and selective enrichment of Panax notoginseng saponin metabolites in rat faeces. Saponins 171-178 RB transcriptional corepressor 1 Rattus norvegicus 16-19 27240301-4 2016 Then the in vitro anti-inflammatory activity of 27 compounds were evaluated, and 9 saponins, 11 bile acids, taurine and muscone exhibited significant inhibitory activities on TNF-alpha production with IC50 values ranging from 12.34 to 147.24muM. Saponins 83-91 tumor necrosis factor Homo sapiens 175-184 27288754-0 2016 Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo. Saponins 18-26 ras homolog family member A Homo sapiens 70-74 27288754-0 2016 Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo. Saponins 18-26 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 75-80 27288754-3 2016 AIMS OF THE STUDY: This study explored whether panax notoginseng saponins (PNS) provided neuroprotective effects by inhibiting the expressions of NgR1, RhoA, and ROCK2 following middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) injury in SH-SY5Y cells. Saponins 65-73 ras homolog family member A Homo sapiens 152-156 27288754-3 2016 AIMS OF THE STUDY: This study explored whether panax notoginseng saponins (PNS) provided neuroprotective effects by inhibiting the expressions of NgR1, RhoA, and ROCK2 following middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) injury in SH-SY5Y cells. Saponins 65-73 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 162-167 27223851-2 2016 The inhibitory effects on UGTs via nor-oleanane triterpenoid saponins, which were the bioactive ingredients from Stauntonia brachyanthera, a traditional Chinese folk medicines with highly biological values, were evaluated comprehensively with recombinant UGT isoforms as enzyme source and a nonspecific substrate 4-methylumbelliferone (4-MU) as substrate. Saponins 61-69 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 26-29 27295967-2 2016 The ginsenoside Rb1 magnetic molecular imprinted polymers (Rb1-MMIPs) were successfully synthesized for specific recognition and selective enrichment of Panax notoginseng saponin metabolites in rat faeces. Saponins 171-178 RB transcriptional corepressor 1 Rattus norvegicus 59-62 27295967-5 2016 Dispersion solid-phase extraction using Rb1-MMIPs (Rb1-MMIPs-DSPE) integrated with LTQ-Orbitrap MS was applied to fish out and identify saponin metabolites from rat faeces, and totally 58 related compounds were detected within 20min, including 26 PPD-group and 32 PPT-group notoginsenoside metabolites. Saponins 136-143 RB transcriptional corepressor 1 Rattus norvegicus 40-43 27295967-5 2016 Dispersion solid-phase extraction using Rb1-MMIPs (Rb1-MMIPs-DSPE) integrated with LTQ-Orbitrap MS was applied to fish out and identify saponin metabolites from rat faeces, and totally 58 related compounds were detected within 20min, including 26 PPD-group and 32 PPT-group notoginsenoside metabolites. Saponins 136-143 RB transcriptional corepressor 1 Rattus norvegicus 51-54 27283034-1 2016 A series of saponins and sapogenins from Medicago species were tested for their ability to bind and activate the nuclear receptor PPARgamma by SPR experiments and transactivation assay, respectively. Saponins 12-20 peroxisome proliferator activated receptor gamma Homo sapiens 130-139 26976272-4 2016 The immunogenicity of rLiHyD/saponin vaccine was evaluated, and the results showed that immunized mice produced high levels of IFN-gamma, IL-12 and GM-CSF after in vitro stimulation with rLiHyD, as well as by using L. major or L. braziliensis protein extracts. Saponins 29-36 interferon gamma Mus musculus 127-136 26976272-4 2016 The immunogenicity of rLiHyD/saponin vaccine was evaluated, and the results showed that immunized mice produced high levels of IFN-gamma, IL-12 and GM-CSF after in vitro stimulation with rLiHyD, as well as by using L. major or L. braziliensis protein extracts. Saponins 29-36 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 148-154 26976272-7 2016 The partial protection obtained by the rLiHyD/saponin vaccine was associated with a parasite-specific IL-12-dependent IFN-gamma secretion, which was produced mainly by CD4(+) T cells. Saponins 46-53 interferon gamma Mus musculus 118-127 27118322-5 2016 The known spirostanol saponins 7 and 8 exhibited notable cytotoxicity against the two tumor cell lines with IC50 values of 1.13 and 3.42muM, respectively, while the new furostanol saponins 3 and 4 showed moderate cytotoxicity with IC50 values of 15.28 to 16.98muM. Saponins 22-30 latexin Homo sapiens 136-139 25533511-13 2016 The proliferative effects of these saponins on HUVECs were effectively blocked by the addition of SU5416 (a VEGF-KDR/Flk-1 inhibitor). Saponins 35-43 vascular endothelial growth factor Aa Danio rerio 108-112 25533511-13 2016 The proliferative effects of these saponins on HUVECs were effectively blocked by the addition of SU5416 (a VEGF-KDR/Flk-1 inhibitor). Saponins 35-43 kinase insert domain receptor (a type III receptor tyrosine kinase) Danio rerio 113-116 25533511-13 2016 The proliferative effects of these saponins on HUVECs were effectively blocked by the addition of SU5416 (a VEGF-KDR/Flk-1 inhibitor). Saponins 35-43 kinase insert domain receptor (a type III receptor tyrosine kinase) Danio rerio 117-122 27082009-11 2016 Following detection of IL-17 mRNA and protein expression levels in the ocular tissues of rats of the five groups, it was found that their expression was lowest in the saponin-treated group and the other differences in expression were all statistically significant (P<0.05). Saponins 167-174 interleukin 17A Rattus norvegicus 23-28 27105508-3 2016 We found that the combination of the saponin monomer 13 from the dwarf lilyturf tuber (DT-13), performing anti-metastasis and anti-angiogenesis effects, with TPT synergistically induced apoptotic cytotoxicity in GCs with high EGF receptor (EGFR) expression, which was dependent on DT-13-induced endocytosis of EGFR. Saponins 37-44 epidermal growth factor receptor Homo sapiens 226-238 27105508-3 2016 We found that the combination of the saponin monomer 13 from the dwarf lilyturf tuber (DT-13), performing anti-metastasis and anti-angiogenesis effects, with TPT synergistically induced apoptotic cytotoxicity in GCs with high EGF receptor (EGFR) expression, which was dependent on DT-13-induced endocytosis of EGFR. Saponins 37-44 epidermal growth factor receptor Homo sapiens 240-244 27105508-3 2016 We found that the combination of the saponin monomer 13 from the dwarf lilyturf tuber (DT-13), performing anti-metastasis and anti-angiogenesis effects, with TPT synergistically induced apoptotic cytotoxicity in GCs with high EGF receptor (EGFR) expression, which was dependent on DT-13-induced endocytosis of EGFR. Saponins 37-44 epidermal growth factor receptor Homo sapiens 310-314 26915440-1 2016 BACKGROUND: We aimed to study the effect of Panax notoginseng saponins (PNS) on the proliferation, differentiation, self-renewal, and expressions of basic fibroblast growth factor (bFGF) and brain-derived neurotrophic factor (BDNF) in rat embryonic neural stem cells (NSCs). Saponins 62-70 fibroblast growth factor 2 Rattus norvegicus 181-185 26915440-1 2016 BACKGROUND: We aimed to study the effect of Panax notoginseng saponins (PNS) on the proliferation, differentiation, self-renewal, and expressions of basic fibroblast growth factor (bFGF) and brain-derived neurotrophic factor (BDNF) in rat embryonic neural stem cells (NSCs). Saponins 62-70 brain-derived neurotrophic factor Rattus norvegicus 226-230 26947206-0 2016 Effects of total saponins from Rhizoma Dioscoreae Nipponicae on expression of vascular endothelial growth factor and angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid arthritis. Saponins 17-25 vascular endothelial growth factor A Rattus norvegicus 78-112 26947206-0 2016 Effects of total saponins from Rhizoma Dioscoreae Nipponicae on expression of vascular endothelial growth factor and angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid arthritis. Saponins 17-25 angiopoietin 2 Rattus norvegicus 117-131 26784885-0 2016 Panax notoginseng saponins ameliorate impaired arterial vasodilation in SHRSP.Z-Lepr(fa) /lzmDmcr rats with metabolic syndrome. Saponins 18-26 leptin receptor Rattus norvegicus 80-84 26947206-1 2016 BACKGROUND: This study aimed to determine the effects of total saponins from Rhizoma Dioscoreae Nipponicae (TS-RDN) on the expression of vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-2 and Tie-2 (endothelial tyrosine kinase receptor) receptors in the synovium of rats with rheumatoid arthritis (RA) (collagen-induced arthritis; CIA), and to examine the mechanisms of TS-RDN in alleviating RA. Saponins 63-71 vascular endothelial growth factor A Rattus norvegicus 137-171 26947206-1 2016 BACKGROUND: This study aimed to determine the effects of total saponins from Rhizoma Dioscoreae Nipponicae (TS-RDN) on the expression of vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-2 and Tie-2 (endothelial tyrosine kinase receptor) receptors in the synovium of rats with rheumatoid arthritis (RA) (collagen-induced arthritis; CIA), and to examine the mechanisms of TS-RDN in alleviating RA. Saponins 63-71 vascular endothelial growth factor A Rattus norvegicus 173-177 26947206-1 2016 BACKGROUND: This study aimed to determine the effects of total saponins from Rhizoma Dioscoreae Nipponicae (TS-RDN) on the expression of vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-2 and Tie-2 (endothelial tyrosine kinase receptor) receptors in the synovium of rats with rheumatoid arthritis (RA) (collagen-induced arthritis; CIA), and to examine the mechanisms of TS-RDN in alleviating RA. Saponins 63-71 angiogenin, ribonuclease A family, member 2 Rattus norvegicus 183-203 26947206-1 2016 BACKGROUND: This study aimed to determine the effects of total saponins from Rhizoma Dioscoreae Nipponicae (TS-RDN) on the expression of vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-2 and Tie-2 (endothelial tyrosine kinase receptor) receptors in the synovium of rats with rheumatoid arthritis (RA) (collagen-induced arthritis; CIA), and to examine the mechanisms of TS-RDN in alleviating RA. Saponins 63-71 TEK receptor tyrosine kinase Rattus norvegicus 208-213 27074384-0 2016 The Hypolipidemic Effect of Total Saponins from Kuding Tea in High-Fat Diet-Induced Hyperlipidemic Mice and Its Composition Characterized by UPLC-QTOF-MS/MS. Saponins 34-42 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 55-58 27074384-2 2016 In this study, total saponins (TS) from water extract of Kuding tea was prepared by D101 macroporous resins and analyzed by UPLC-QTOF-MS/MS. Saponins 21-29 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 64-67 27074384-5 2016 As a result, 52 saponins were identified or characterized in TS extract from Kuding tea. Saponins 16-24 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 84-87 27074384-11 2016 These results give the evidence that the saponins in Kuding tea could provide benefits in managing hypercholesterolemia and may be a good candidate for development as a functional food and nutraceutical. Saponins 41-49 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 60-63 27125283-9 2016 CONCLUSIONS The underlying mechanism of Paris saponins may be related to targeting the PI3K/AKT pathways to cause apoptosis. Saponins 46-54 AKT serine/threonine kinase 1 Homo sapiens 92-95 27060963-2 2016 Our previous study reported that gypenoside XVII (GP-17), which is a major saponin abundant in ginseng and Panax notoginseng, ameliorated amyloid-beta (Abeta)25-35-induced apoptosis in PC12 cells by regulating autophagy. Saponins 75-82 prolactin induced protein Mus musculus 50-55 27241254-15 2016 Thus, our hypothesis is that the saponins derived from fungal endophytes can be explored as clinical applicable leptin inhibitors for treating immune mediated diseases. Saponins 33-41 leptin Homo sapiens 112-118 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 18-26 Rh associated glycoprotein Homo sapiens 100-103 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 18-26 RB transcriptional corepressor 1 Homo sapiens 197-200 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 18-26 RB transcriptional corepressor like 2 Homo sapiens 202-205 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 166-174 Rh associated glycoprotein Homo sapiens 100-103 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 166-174 RB transcriptional corepressor 1 Homo sapiens 197-200 27158230-1 2016 BACKGROUND: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. Saponins 166-174 RB transcriptional corepressor like 2 Homo sapiens 202-205 27400477-0 2016 Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/ Stat3 pathways. Saponins 18-26 Janus kinase 2 Rattus norvegicus 127-131 27400477-0 2016 Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/ Stat3 pathways. Saponins 18-26 signal transducer and activator of transcription 3 Rattus norvegicus 133-138 26998045-4 2016 The aim of the present study was to identify the anti-inflammatory effects of total saponins extracted from ginseng (TSG) on lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages. Saponins 84-92 twisted gastrulation BMP signaling modulator 1 Mus musculus 117-120 26701355-0 2016 Fast Centrifugal Partition Chromatography Fractionation of Concentrated Agave (Agave salmiana) Sap to Obtain Saponins with Apoptotic Effect on Colon Cancer Cells. Saponins 109-117 SH2 domain containing 1A Homo sapiens 95-98 25575679-5 2016 Treatment with traditional Chinese anti-aging medicine Xueshuangtong (Panax notoginseng saponins, PNS) significantly reversed the SCN2B expressions in the prefrontal cortex, resulting in improved learning and memory. Saponins 88-96 sodium channel, voltage-gated, type II, beta Mus musculus 130-135 26888485-2 2016 Notoginsenoside R1 (NGR1) is a novel saponin isolated from P. notoginseng, which has a history of prevention and treatment of cardiovascular diseases. Saponins 37-44 reticulon 4 receptor Rattus norvegicus 0-18 27168752-10 2016 Flow cytometry showed that optimum concentration of saponin promoted oocyte maturation via down regulation of TNF-alpha as follicular degenerative factor in nursing cells. Saponins 52-59 tumor necrosis factor Mus musculus 110-119 27168752-12 2016 Moreover, the extracted saponin at concentrations of 1, 2 mug/ml enhanced follicle growth which is accompanied by attenuating ROS formation, elevating SOD activity and reducing TNF-alpha expression in granulosa cells. Saponins 24-31 tumor necrosis factor Mus musculus 177-186 26732631-8 2016 Saponins from the YTN CMM Glycyrrhiza uralensis (Sgu) were the most potent promoters of IL-1beta and TNF-alpha release. Saponins 0-8 interleukin 1 beta Mus musculus 88-96 26732631-8 2016 Saponins from the YTN CMM Glycyrrhiza uralensis (Sgu) were the most potent promoters of IL-1beta and TNF-alpha release. Saponins 0-8 tumor necrosis factor Mus musculus 101-110 26888485-2 2016 Notoginsenoside R1 (NGR1) is a novel saponin isolated from P. notoginseng, which has a history of prevention and treatment of cardiovascular diseases. Saponins 37-44 reticulon 4 receptor Rattus norvegicus 20-24 26593442-3 2016 In the results, it is shown that rLiHyT plus saponin vaccinated mice produced high levels of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation of spleen cells using both rLiHyT and Leishmania infantum SLA. Saponins 45-52 interferon gamma Mus musculus 93-102 26861252-2 2016 Polyphyllin VII (PP7), a pennogenyl saponin from P. polyphylla has been found to exert strong anticancer activity. Saponins 36-43 protein phosphatase with EF-hand domain 1 Homo sapiens 17-20 26593442-3 2016 In the results, it is shown that rLiHyT plus saponin vaccinated mice produced high levels of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation of spleen cells using both rLiHyT and Leishmania infantum SLA. Saponins 45-52 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 115-121 26272548-1 2016 OBJECTIVE: To evaluate the efficacy and safety of Pai-Neng-Da Capsule (panaxadiol saponins component, PND), a new Chinese patent medicine, on patients with chronic aplastic anemia (CAA) and to explore the optimal therapeutic regimen for CAA. Saponins 82-90 serpin family E member 1 Homo sapiens 50-53 26709796-3 2016 LCWE or saponin wad found to produce membrane injury, which was resealed in a Ca(2+)-dependent manner, but abolished by FasL, a membrane raft (MR) clustering stimulator. Saponins 8-15 Fas ligand (TNF superfamily, member 6) Mus musculus 120-124 26833423-0 2016 Novel microspheres based on triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae) for the improvement of gemcitabine release. Saponins 39-47 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 107-110 26567319-2 2016 Notoginsenoside Ft1 (Ft1), a saponin from Panax notoginseng, can enhance platelet aggregation by activating signaling network mediated through P2Y12 and induce proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells. Saponins 29-36 AKT interacting protein Homo sapiens 16-19 26567319-2 2016 Notoginsenoside Ft1 (Ft1), a saponin from Panax notoginseng, can enhance platelet aggregation by activating signaling network mediated through P2Y12 and induce proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells. Saponins 29-36 AKT interacting protein Homo sapiens 21-24 26808193-1 2016 Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types. Saponins 36-43 protein phosphatase with EF-hand domain 1 Homo sapiens 17-20 26555265-7 2016 A nanoparticulate adjuvant that contains QS-21 as part of a heterogeneous mixture of saponins also induced IL-1beta in an NLRP3-dependent manner. Saponins 85-93 interleukin 1 beta Homo sapiens 107-115 26555265-9 2016 Thus, we have identified QS-21 as a nonparticulate single molecular saponin that activates the NLRP3 inflammasome, but this signaling pathway may contribute to decreased antigen-specific responses in vivo. Saponins 68-75 NLR family pyrin domain containing 3 Homo sapiens 95-100 26521655-5 2016 The structural elucidation of complex saponins possessing from 5 to 8 sugar units is performed by a combination of extensive spectroscopic techniques including 1D- and 2D-NMR experiments (1H, 13C, DEPT, COSY, NOESY, TOCSY, HSQC, HMBC) and mass spectrometry (FAB-MS HRESIMS). Saponins 38-46 FA complementation group B Homo sapiens 258-261 30188622-3 2016 The aim of the study was to determine the modifying effect of cryoprotectant PEG-1500 and low temperatures on the Ca2+-ATPase activity using the model of the saponin-permeabilized erythrocytes. Saponins 158-165 carbonic anhydrase 2 Homo sapiens 114-117 26650797-0 2016 Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways. Saponins 6-14 thymoma viral proto-oncogene 1 Mus musculus 108-111 26650797-0 2016 Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways. Saponins 6-14 mechanistic target of rapamycin kinase Mus musculus 112-116 26650797-0 2016 Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways. Saponins 6-14 mitogen-activated protein kinase 14 Mus musculus 121-124 26648253-0 2015 Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway. Saponins 11-18 sirtuin 1 Rattus norvegicus 52-57 26648253-0 2015 Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway. Saponins 11-18 mitogen activated protein kinase 3 Rattus norvegicus 58-64 26603552-1 2015 Quillaja saponins, e.g. QS-21, are immunomodulating aldehyde-carrying triterpene glycosides, which depending on the acylation state of their single fucosyl residue (Fucp) induce either Th1/Th2 or Th2 immunity. Saponins 9-17 negative elongation factor complex member C/D Homo sapiens 185-188 26475038-1 2015 Saikosaponin a (SSa), the major triterpenoid saponin derivatives from Radix bupleuri (RB), has been reported to have anti-inflammatory effects. Saponins 5-12 tripartite motif containing 21 Homo sapiens 16-19 26603552-6 2015 saponins results once more in the induction of Th1/Th2 immunity supports the Fucp role in polarizing the response toward Th2 immunity. Saponins 0-8 negative elongation factor complex member C/D Homo sapiens 47-50 26420067-0 2015 New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. Saponins 55-63 sirtuin 1 Homo sapiens 4-9 26498380-1 2015 It was previously shown that total saponins extracted from Aralia taibaiensis (sAT) have potent antioxidant activities for treating diabetes mellitus and attenuate d-galactose-induced aging. Saponins 35-43 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 79-82 26343612-9 2015 Subsequently, the inhibitory effects of four saponins and 14 plant extracts on the activity of surface displayed Hyal-1 were evaluated. Saponins 45-53 hyaluronidase 1 Homo sapiens 113-119 26367128-7 2015 Spleen cells from mice inoculated with the individual proteins or with the polyproteins vaccine plus saponin showed a protein-specific production of IFN-gamma, IL-12, and GM-CSF after an in vitro stimulation, which was maintained after infection. Saponins 101-108 interferon gamma Mus musculus 149-158 26367128-7 2015 Spleen cells from mice inoculated with the individual proteins or with the polyproteins vaccine plus saponin showed a protein-specific production of IFN-gamma, IL-12, and GM-CSF after an in vitro stimulation, which was maintained after infection. Saponins 101-108 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 171-177 26989747-0 2015 Transcriptional analysis of VEGF-D and TGFbeta genes in MCF7 cells exposed to saponin isolated from Holothuria leucospilota (sea cucumber). Saponins 78-85 vascular endothelial growth factor D Homo sapiens 28-34 26989747-0 2015 Transcriptional analysis of VEGF-D and TGFbeta genes in MCF7 cells exposed to saponin isolated from Holothuria leucospilota (sea cucumber). Saponins 78-85 transforming growth factor beta 1 Homo sapiens 39-46 26989747-3 2015 In this study we examined the anti-angiogenic effect of saponin isolated from Holothuria leucospilota (sea cucumber) through evaluation of vascular endothelial growth factor D (VEGF-D) and transforming growth factor-beta (TGFbeta) expression in a breast cancer cell line. Saponins 56-63 vascular endothelial growth factor D Homo sapiens 177-183 26989747-3 2015 In this study we examined the anti-angiogenic effect of saponin isolated from Holothuria leucospilota (sea cucumber) through evaluation of vascular endothelial growth factor D (VEGF-D) and transforming growth factor-beta (TGFbeta) expression in a breast cancer cell line. Saponins 56-63 transforming growth factor beta 1 Homo sapiens 222-229 26989747-7 2015 Sea cucumber saponin at a concentration of 12 mug/ml inhibited VEGF-D and TGFbeta expression more than 90% compared with controls. Saponins 13-20 vascular endothelial growth factor D Homo sapiens 63-69 26989747-7 2015 Sea cucumber saponin at a concentration of 12 mug/ml inhibited VEGF-D and TGFbeta expression more than 90% compared with controls. Saponins 13-20 transforming growth factor beta 1 Homo sapiens 74-81 26160291-10 2015 After challenge with L. infantum, spleen cells of BALB/c mice vaccinated with rLiHyV/saponin stimulated with parasite antigens showed a higher production of IFN-gamma, IL-12 and GM-CSF, than the same cells obtained from mice vaccinated with the individual peptides, or mice from control (inoculated with saline or saponin) groups. Saponins 85-92 interferon gamma Mus musculus 157-166 26220630-0 2015 Aldose reductase inhibition of a saponin-rich fraction and new furostanol saponin derivatives from Balanites aegyptiaca. Saponins 33-40 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 26220630-18 2015 CONCLUSION: The aldose reductase inhibitory activity of Balanites fruits is due to the steroidal saponins present. Saponins 97-105 aldo-keto reductase family 1 member B1 Rattus norvegicus 16-32 26295969-3 2015 This present study reports on the evaluation of cytotoxic effects and explanation of the molecular mechanisms of action of the two pennogenyl saponins (PS 1 and PS 2) isolated from Paris quadrifolia L. rhizomes on human cervical adenocarcinoma cell line HeLa. Saponins 142-150 taste 2 receptor member 62 pseudogene Homo sapiens 152-156 26295969-3 2015 This present study reports on the evaluation of cytotoxic effects and explanation of the molecular mechanisms of action of the two pennogenyl saponins (PS 1 and PS 2) isolated from Paris quadrifolia L. rhizomes on human cervical adenocarcinoma cell line HeLa. Saponins 142-150 taste 2 receptor member 64 pseudogene Homo sapiens 161-165 26295969-4 2015 To determine the viability of the cells treated with the compounds we used real-time cell proliferation analysis and found that the pennogenyl saponins PS 1 and PS 2 strongly inhibited the tumor cells growth with IC50 values of 1.11 +- 0.04 mug/ml and 0.87 +- 0.05 mug/ml, respectively. Saponins 143-151 taste 2 receptor member 62 pseudogene Homo sapiens 152-156 26295969-6 2015 Quantitative PCR and Western Blot analysis showed that the two saponins significantly increased mRNA expression of FADD and BID as well as induced caspase-8 via increased of procaspase-8 processing in the treated cells. Saponins 63-71 Fas associated via death domain Homo sapiens 115-119 26295969-6 2015 Quantitative PCR and Western Blot analysis showed that the two saponins significantly increased mRNA expression of FADD and BID as well as induced caspase-8 via increased of procaspase-8 processing in the treated cells. Saponins 63-71 BH3 interacting domain death agonist Homo sapiens 124-127 26295969-6 2015 Quantitative PCR and Western Blot analysis showed that the two saponins significantly increased mRNA expression of FADD and BID as well as induced caspase-8 via increased of procaspase-8 processing in the treated cells. Saponins 63-71 caspase 8 Homo sapiens 147-156 26487862-5 2015 Furthermore, at 7 days, more NGF- and BDNF-immunoreactive neurons were observed in the ventral horn of the spinal cord of rats that had received Panax notoginseng saponins than in those that received saline. Saponins 163-171 nerve growth factor Rattus norvegicus 29-32 26487862-5 2015 Furthermore, at 7 days, more NGF- and BDNF-immunoreactive neurons were observed in the ventral horn of the spinal cord of rats that had received Panax notoginseng saponins than in those that received saline. Saponins 163-171 brain-derived neurotrophic factor Rattus norvegicus 38-42 26487862-6 2015 These results indicate that Panax notoginseng saponins caused an upregulation of NGF and BDNF in rats with spinal cord transection, and improved hindlimb motor function. Saponins 46-54 nerve growth factor Rattus norvegicus 81-84 26487862-6 2015 These results indicate that Panax notoginseng saponins caused an upregulation of NGF and BDNF in rats with spinal cord transection, and improved hindlimb motor function. Saponins 46-54 brain-derived neurotrophic factor Rattus norvegicus 89-93 26160291-10 2015 After challenge with L. infantum, spleen cells of BALB/c mice vaccinated with rLiHyV/saponin stimulated with parasite antigens showed a higher production of IFN-gamma, IL-12 and GM-CSF, than the same cells obtained from mice vaccinated with the individual peptides, or mice from control (inoculated with saline or saponin) groups. Saponins 85-92 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 178-184 26160291-11 2015 This Th1-type cellular response observed in rLiHyV/saponin vaccinated mice was accompanied by the induction of parasite-specific IgG2a isotype antibodies. Saponins 51-58 immunoglobulin heavy variable V1-9 Mus musculus 129-134 25712888-0 2015 Inhibition of matrix metalloproteinase-13 expression in IL-1beta-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action. Saponins 111-118 matrix metallopeptidase 13 Homo sapiens 14-41 26666018-9 2015 Histamine, VEGF and TNF-alpha levels in notoginseng total saponin preparation middle-dose group and high-dose group significantly increased (P < 0.05, P < 0.01) than control group and showed a dose-dependent manner as well as consistent with the degree of ear blue dye. Saponins 58-65 tumor necrosis factor Mus musculus 20-29 26666018-11 2015 So pseadoanaphylactoid reaction caused by notoginseng total saponin preparation may be related to histamine, VEGF, TNF-alpha, and it is possible that IL-6 and IL-10 can play a role when pseadoanaphylactoid reaction achieve a certain high degree. Saponins 60-67 vascular endothelial growth factor A Mus musculus 109-113 26666018-11 2015 So pseadoanaphylactoid reaction caused by notoginseng total saponin preparation may be related to histamine, VEGF, TNF-alpha, and it is possible that IL-6 and IL-10 can play a role when pseadoanaphylactoid reaction achieve a certain high degree. Saponins 60-67 tumor necrosis factor Mus musculus 115-124 25836593-5 2015 Catalase was loaded into exosomes ex vivo using different methods: the incubation at room temperature, permeabilization with saponin, freeze-thaw cycles, sonication, or extrusion. Saponins 125-132 catalase Mus musculus 0-8 25836593-7 2015 A reformation of exosomes upon sonication and extrusion, or permeabilization with saponin resulted in high loading efficiency, sustained release, and catalase preservation against proteases degradation. Saponins 82-89 catalase Mus musculus 150-158 26157351-0 2015 The saponin DT-13 attenuates tumor necrosis factor-alpha-induced vascular inflammation associated with Src/NF-kB/MAPK pathway modulation. Saponins 4-11 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 103-106 25712888-0 2015 Inhibition of matrix metalloproteinase-13 expression in IL-1beta-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action. Saponins 111-118 interleukin 1 beta Homo sapiens 56-64 26762065-8 2015 RESULTS: Total saponins of Panacis Majoris Rhizoma might significantly decrease the levels of serum TNF-alpha, IL-1beta, IL-6 and IL-8; decrease myocardial hypertrophy indexes, myocardial infarct size, degree of ventricular dilatation and myocardial interstitial collagen volume fraction; improve heart tissue morphology and cardiac function; downregulate protein expression of pIkappaB-alpha and NF-kappaBp65; and upregulate protein expression of SIRT1. Saponins 15-23 tumor necrosis factor Rattus norvegicus 100-109 25625570-0 2015 Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2/MAPK/Smad-dependent Runx2 pathway. Saponins 20-28 bone morphogenetic protein 2 Mus musculus 77-105 25625570-0 2015 Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2/MAPK/Smad-dependent Runx2 pathway. Saponins 20-28 runt related transcription factor 2 Mus musculus 126-131 26762065-8 2015 RESULTS: Total saponins of Panacis Majoris Rhizoma might significantly decrease the levels of serum TNF-alpha, IL-1beta, IL-6 and IL-8; decrease myocardial hypertrophy indexes, myocardial infarct size, degree of ventricular dilatation and myocardial interstitial collagen volume fraction; improve heart tissue morphology and cardiac function; downregulate protein expression of pIkappaB-alpha and NF-kappaBp65; and upregulate protein expression of SIRT1. Saponins 15-23 interleukin 1 beta Rattus norvegicus 111-119 26762065-8 2015 RESULTS: Total saponins of Panacis Majoris Rhizoma might significantly decrease the levels of serum TNF-alpha, IL-1beta, IL-6 and IL-8; decrease myocardial hypertrophy indexes, myocardial infarct size, degree of ventricular dilatation and myocardial interstitial collagen volume fraction; improve heart tissue morphology and cardiac function; downregulate protein expression of pIkappaB-alpha and NF-kappaBp65; and upregulate protein expression of SIRT1. Saponins 15-23 interleukin 6 Rattus norvegicus 121-125 26762065-8 2015 RESULTS: Total saponins of Panacis Majoris Rhizoma might significantly decrease the levels of serum TNF-alpha, IL-1beta, IL-6 and IL-8; decrease myocardial hypertrophy indexes, myocardial infarct size, degree of ventricular dilatation and myocardial interstitial collagen volume fraction; improve heart tissue morphology and cardiac function; downregulate protein expression of pIkappaB-alpha and NF-kappaBp65; and upregulate protein expression of SIRT1. Saponins 15-23 sirtuin 1 Rattus norvegicus 448-453 25875901-9 2015 We showed that 2-152a MAb-mediated binding of a cytotoxic agent (a saponin-conjugated secondary antibody) to surface DHCR24 led to significant cytotoxicity. Saponins 67-74 24-dehydrocholesterol reductase Homo sapiens 117-123 25895106-0 2015 Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. Saponins 49-57 interleukin 6 Homo sapiens 119-123 25895106-0 2015 Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. Saponins 49-57 signal transducer and activator of transcription 3 Homo sapiens 132-137 26159026-17 2015 Compared with the model group, the expression of cortical Syt-1 increased in the saponin group and the benzene group; the expression of cortical IL-1beta increased in the benzene group and the polysaccharide group; the expression of hippocampal GFAP increased in the three kinds extracts of QKR groups; expression levels of Syt-1, IL-1beta, GFAP, and beta-APP in the cortex and hippocampus decreased in the rest treatment groups (all P < 0.05, P < 0.01). Saponins 81-88 synaptotagmin 1 Rattus norvegicus 58-63 25797537-5 2015 The known saponins 12, 16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 muM, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 muM. Saponins 10-18 butyrylcholinesterase Rattus norvegicus 171-185 25607254-0 2015 Total saponins from Albizia julibrissin inhibit vascular endothelial growth factor-mediated angiogenesis in vitro and in vivo. Saponins 6-14 vascular endothelial growth factor A Homo sapiens 48-82 25595597-8 2015 Detailed mechanistic studies with sonicated or saponin-treated CHHs, human liver microsomes, and S9 fractions showed that both NADPH and UDP-glucuronic acid are required for 3-hydroxydesloratadine formation, and studies with recombinant UDP-glucuronosyltransferase (UGT) and P450 enzymes implicated the specific involvement of UGT2B10 in addition to CYP2C8. Saponins 47-54 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 237-264 25762407-0 2015 Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation. Saponins 56-63 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 34-37 25600909-0 2015 Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: a unique action mode of saponin compounds with poor bioavailability. Saponins 147-154 interleukin 10 Rattus norvegicus 11-25 25595597-8 2015 Detailed mechanistic studies with sonicated or saponin-treated CHHs, human liver microsomes, and S9 fractions showed that both NADPH and UDP-glucuronic acid are required for 3-hydroxydesloratadine formation, and studies with recombinant UDP-glucuronosyltransferase (UGT) and P450 enzymes implicated the specific involvement of UGT2B10 in addition to CYP2C8. Saponins 47-54 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 266-269 25595597-8 2015 Detailed mechanistic studies with sonicated or saponin-treated CHHs, human liver microsomes, and S9 fractions showed that both NADPH and UDP-glucuronic acid are required for 3-hydroxydesloratadine formation, and studies with recombinant UDP-glucuronosyltransferase (UGT) and P450 enzymes implicated the specific involvement of UGT2B10 in addition to CYP2C8. Saponins 47-54 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 327-334 25595597-8 2015 Detailed mechanistic studies with sonicated or saponin-treated CHHs, human liver microsomes, and S9 fractions showed that both NADPH and UDP-glucuronic acid are required for 3-hydroxydesloratadine formation, and studies with recombinant UDP-glucuronosyltransferase (UGT) and P450 enzymes implicated the specific involvement of UGT2B10 in addition to CYP2C8. Saponins 47-54 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 350-356 25590691-0 2015 Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells. Saponins 0-8 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 99-108 25590691-1 2015 We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. Saponins 79-87 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 116-125 25590691-1 2015 We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. Saponins 98-106 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 116-125 26075266-9 2015 We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Saponins 106-114 brain derived neurotrophic factor Homo sapiens 132-144 25123353-0 2015 ASC, a bioactive steroidal saponin from Ophitopogin japonicas, inhibits angiogenesis through interruption of Src tyrosine kinase-dependent matrix metalloproteinase pathway. Saponins 27-34 PYD and CARD domain containing Homo sapiens 0-3 25123353-2 2015 In this study, we investigated a potent angiogenesis inhibitor, ASC, a steroidal saponin compound, which has been purified from Ophitopogin japonicus (L.f) Ker.-Gawl. Saponins 81-88 PYD and CARD domain containing Homo sapiens 64-67 25652852-0 2015 [Total saponins of Clematis inhibits JAK2/STAT3 signal pathway of adjuvant-induced arthritis rats]. Saponins 7-15 Janus kinase 2 Rattus norvegicus 37-41 25652852-0 2015 [Total saponins of Clematis inhibits JAK2/STAT3 signal pathway of adjuvant-induced arthritis rats]. Saponins 7-15 signal transducer and activator of transcription 3 Rattus norvegicus 42-47 25562722-2 2015 The aim of the study was to evaluate the anticancer properties of four pennogenyl saponins (PS1-PS4) on a panel of human cancer and normal cell lines, and explore the potential mechanisms underlying the selective anticancer effects of the steroidal saponins in cancer cells. Saponins 82-90 taste 2 receptor member 62 pseudogene Homo sapiens 92-99 25993753-0 2015 [Effect of total saponins from rhizoma dioscoreae nipponicae on the expression of SDF1 and HCIKB kinase in rIK-1beta induced fibroblast-like synoviocytes]. Saponins 17-25 C-X-C motif chemokine ligand 12 Homo sapiens 82-86 25993753-1 2015 OBJECTIVE: To study the effect of total saponins from Rhizoma Dioscoreae nipponicae (RDN) on the expression of stroma cell derived factor 1 (SDF1) and IKB kinase (IKK) in rIL-1beta induced fibroblast-like synoviocytes (FLS). Saponins 40-48 C-X-C motif chemokine ligand 12 Homo sapiens 111-139 25993753-1 2015 OBJECTIVE: To study the effect of total saponins from Rhizoma Dioscoreae nipponicae (RDN) on the expression of stroma cell derived factor 1 (SDF1) and IKB kinase (IKK) in rIL-1beta induced fibroblast-like synoviocytes (FLS). Saponins 40-48 C-X-C motif chemokine ligand 12 Homo sapiens 141-145 25993753-1 2015 OBJECTIVE: To study the effect of total saponins from Rhizoma Dioscoreae nipponicae (RDN) on the expression of stroma cell derived factor 1 (SDF1) and IKB kinase (IKK) in rIL-1beta induced fibroblast-like synoviocytes (FLS). Saponins 40-48 interleukin 1 beta Rattus norvegicus 171-180 25993753-8 2015 CONCLUSIONS: Total saponins from RDN could inhibit the activation of both SDF1 and p-IKK. Saponins 19-27 C-X-C motif chemokine ligand 12 Homo sapiens 74-78 26107236-5 2015 The anti-invasive activity of extracted saponins was examined through adhesion of HeLa cells to extracellular matrix, wound healing and evaluation of the mRNA levels of MMP-2 and MMP-9 by real time-PCR. Saponins 40-48 matrix metallopeptidase 2 Homo sapiens 169-174 26107236-5 2015 The anti-invasive activity of extracted saponins was examined through adhesion of HeLa cells to extracellular matrix, wound healing and evaluation of the mRNA levels of MMP-2 and MMP-9 by real time-PCR. Saponins 40-48 matrix metallopeptidase 9 Homo sapiens 179-184 26107236-9 2015 The significant dose dependent down regulation of MMP-2 and MMP-9 in treated cells demonstrated that isolated saponins can decline tumor metastasis in vitro. Saponins 110-118 matrix metallopeptidase 2 Homo sapiens 50-55 26107236-9 2015 The significant dose dependent down regulation of MMP-2 and MMP-9 in treated cells demonstrated that isolated saponins can decline tumor metastasis in vitro. Saponins 110-118 matrix metallopeptidase 9 Homo sapiens 60-65 25774540-0 2015 Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes. Saponins 74-81 RB transcriptional corepressor like 2 Homo sapiens 38-41 26089937-5 2015 The results showed that RT saponins inhibited iNOS expression to restore NO to basal level. Saponins 27-35 nitric oxide synthase 2 Homo sapiens 46-50 26089937-6 2015 Moreover, compared with Cu/Zn-SOD, RT saponins (2 mg/kg/d dosage) significantly increased Mn-SOD activity after SAH. Saponins 38-46 superoxide dismutase 2 Homo sapiens 90-96 26089937-9 2015 Our findings demonstrated the beneficial effects of RT saponins in enhancing neuroprotective effects by deducing iNOS activity, normalizing SOD level, and inhibiting p-p38 and p53 expression, hence offering significant therapeutic implications for SAH. Saponins 55-63 nitric oxide synthase 2 Homo sapiens 113-117 26089937-9 2015 Our findings demonstrated the beneficial effects of RT saponins in enhancing neuroprotective effects by deducing iNOS activity, normalizing SOD level, and inhibiting p-p38 and p53 expression, hence offering significant therapeutic implications for SAH. Saponins 55-63 superoxide dismutase 1 Homo sapiens 140-143 26089937-9 2015 Our findings demonstrated the beneficial effects of RT saponins in enhancing neuroprotective effects by deducing iNOS activity, normalizing SOD level, and inhibiting p-p38 and p53 expression, hence offering significant therapeutic implications for SAH. Saponins 55-63 mitogen-activated protein kinase 14 Homo sapiens 168-171 26089937-9 2015 Our findings demonstrated the beneficial effects of RT saponins in enhancing neuroprotective effects by deducing iNOS activity, normalizing SOD level, and inhibiting p-p38 and p53 expression, hence offering significant therapeutic implications for SAH. Saponins 55-63 tumor protein p53 Homo sapiens 176-179 25364265-1 2014 BACKGROUND: Hypoxia-induced vascular endothelial growth factor (VEGF) upregulation and angiogenesis following treatment of hepatocellular carcinoma (HCC) with transarterial embolization (TAE) or transarterial chemoembolization (TACE) may be mediated by ginsenoside Rg3, an anti-angiogenic saponin extracted from ginseng. Saponins 289-296 vascular endothelial growth factor A Rattus norvegicus 64-68 26539217-0 2015 Panax notoginseng Saponins Attenuate Phenotype Switching of Vascular Smooth Muscle Cells Induced by Notch3 Silencing. Saponins 18-26 notch receptor 3 Homo sapiens 100-106 25154304-0 2014 Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-kappaB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. Saponins 21-29 sirtuin 1 Rattus norvegicus 111-116 25064608-4 2014 Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells. Saponins 138-145 2,4-dienoyl-CoA reductase 1 Homo sapiens 63-68 25064608-4 2014 Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells. Saponins 138-145 mitogen-activated protein kinase 8 Homo sapiens 85-88 25064608-4 2014 Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells. Saponins 138-145 PYD and CARD domain containing Homo sapiens 147-150 25652852-1 2015 OBJECTIVE: To evaluate the effect of total saponins of Clematis (TSC) on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal transduction pathway in adjuvant-induced arthritis (AIA) rats and investigate the probable mechanisms. Saponins 43-51 Janus kinase 2 Rattus norvegicus 140-144 25652852-1 2015 OBJECTIVE: To evaluate the effect of total saponins of Clematis (TSC) on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal transduction pathway in adjuvant-induced arthritis (AIA) rats and investigate the probable mechanisms. Saponins 43-51 signal transducer and activator of transcription 3 Rattus norvegicus 145-150 26182666-7 2015 The SMS1 content in the saponin extract of kidney cortex is about 12-fold higher compared to the RIPA extraction procedure. Saponins 24-31 sphingomyelin synthase 1 Homo sapiens 4-8 25563364-0 2015 Changes in gene expression of CXCR4, CCR7 and BCL2 after treatment of breast cancer cells with saponin extract from Tribulus terrestris. Saponins 95-102 C-X-C motif chemokine receptor 4 Homo sapiens 30-35 25563364-0 2015 Changes in gene expression of CXCR4, CCR7 and BCL2 after treatment of breast cancer cells with saponin extract from Tribulus terrestris. Saponins 95-102 C-C motif chemokine receptor 7 Homo sapiens 37-41 25563364-0 2015 Changes in gene expression of CXCR4, CCR7 and BCL2 after treatment of breast cancer cells with saponin extract from Tribulus terrestris. Saponins 95-102 BCL2 apoptosis regulator Homo sapiens 46-50 25563364-7 2015 While CXCR4 expression was reduced in both cell lines, CCR7 and BCL2 levels decreased only in tumorigenic MCF7 cells, implying cell-specificity of the saponin action. Saponins 151-158 C-C motif chemokine receptor 7 Homo sapiens 55-59 25563364-7 2015 While CXCR4 expression was reduced in both cell lines, CCR7 and BCL2 levels decreased only in tumorigenic MCF7 cells, implying cell-specificity of the saponin action. Saponins 151-158 BCL2 apoptosis regulator Homo sapiens 64-68 25480514-0 2014 The saponin DT-13 inhibits gastric cancer cell migration through down-regulation of CCR5-CCL5 axis. Saponins 4-11 C-C motif chemokine receptor 5 Homo sapiens 84-88 25480514-0 2014 The saponin DT-13 inhibits gastric cancer cell migration through down-regulation of CCR5-CCL5 axis. Saponins 4-11 C-C motif chemokine ligand 5 Homo sapiens 89-93 25060691-4 2014 Our previous studies have showed that ginseng total saponins (GTS) exhibited antidiabetic effects partly via modulating GLP-1 release. Saponins 52-60 glucagon Rattus norvegicus 120-125 25333662-6 2014 BALB/c mice vaccinated with clones plus saponin showed both a high and specific production of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation with individual clones or L. infantum extracts. Saponins 40-47 interferon gamma Mus musculus 94-103 25333662-6 2014 BALB/c mice vaccinated with clones plus saponin showed both a high and specific production of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation with individual clones or L. infantum extracts. Saponins 40-47 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 116-122 25108743-7 2014 The reported saponins can be classified into protopanaxadiol, protopanaxatriol, octillol, oleanolic acid, C17 side-chain varied, and miscellaneous subtypes, according to structural differences in sapogenins. Saponins 13-21 cytokine like 1 Homo sapiens 106-109 25213453-2 2014 Here, we investigated the effects of Notoginsenoside R1 (NTR1), a major saponin isolated from Panax notoginseng, on neuronal excitability and assessed the beneficial effects of NTR1 on synaptic and memory deficits under the Abeta-enriched conditions in vivo and in vitro. Saponins 72-79 neurotensin receptor 1 Mus musculus 57-61 25248048-12 2014 Total saponins from Rhizoma Dioscoreae Nipponicae could effectively reverse potassium oxonate-induced alterations in renal mouse urate transporter 1, glucose transporter 9, organic anion transporter 1, and organic anion transporter 3 mRNA and protein levels, resulting in enhancement of renal urate excretion in mice. Saponins 6-14 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 150-233 25577870-1 2014 Ginsenoside Rb3 (GRb3) is one of the main components in plasma of Panax quinquefolius Saponin of stem and leaf (PQS), which can be into human plasma. Saponins 86-93 stathmin 4 Homo sapiens 12-15 25895378-7 2014 The Purple and Green Notoginseng Radix et Rhizoma both contained five saponin monomers whose contents were as follows: ginsenoside Rg1 > ginsenoside Rb1 > notoginsenoside R1 > ginsenoside Rd > ginsenoside Re. Saponins 70-77 protein phosphatase 1 regulatory subunit 3A Homo sapiens 131-134 25895378-7 2014 The Purple and Green Notoginseng Radix et Rhizoma both contained five saponin monomers whose contents were as follows: ginsenoside Rg1 > ginsenoside Rb1 > notoginsenoside R1 > ginsenoside Rd > ginsenoside Re. Saponins 70-77 RB transcriptional corepressor 1 Homo sapiens 152-155 24484214-9 2014 CONCLUSION: Panax notoginseng saponins possess excellent anti-OSF activity, and its mechanism may be related to its ability to inhibit the ANE-induced activation of PI3K/AKT, ERK/JNK/p38 MAPK, and TGFbeta/smad pathways. Saponins 30-38 AKT serine/threonine kinase 1 Homo sapiens 170-173 25073091-0 2014 Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways. Saponins 11-18 sirtuin 1 Homo sapiens 94-99 25073091-0 2014 Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways. Saponins 11-18 superoxide dismutase 2 Homo sapiens 100-106 25073091-0 2014 Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways. Saponins 11-18 heat shock protein family A (Hsp70) member 5 Homo sapiens 111-116 24857982-6 2014 KEY FINDINGS: Among the saponins examined, Ft1 showed the best inhibitory effect on cell proliferation of SH-SY5Y cells with IC50 of 45muM. Saponins 24-32 AKT interacting protein Homo sapiens 43-46 24818584-0 2014 Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation. Saponins 6-13 ATP binding cassette subfamily B member 1 Homo sapiens 118-132 24802169-4 2014 The effect of three food-related proteins (hen egg lysozyme, bovine beta-lactoglobulin and beta-casein) on surface tension of the saponins is also described. Saponins 130-138 beta-lactoglobulin Bos taurus 68-86 24802169-4 2014 The effect of three food-related proteins (hen egg lysozyme, bovine beta-lactoglobulin and beta-casein) on surface tension of the saponins is also described. Saponins 130-138 casein beta Bos taurus 91-102 24802169-8 2014 This is especially well visible for beta-casein/QBS mixtures, where a characteristic maximum in the surface tension isotherm around the molar ratio of one can be noticed for one saponin product, but not for the other. Saponins 178-185 casein beta Bos taurus 36-47 25143813-0 2014 Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana. Saponins 83-91 peroxisome proliferator activated receptor alpha Homo sapiens 22-26 24924952-8 2014 A 24 h exposure to saponin (15 microg/ml) resulted in a significant increase of annexin V binding and a significant stimulation of hemolysis. Saponins 19-26 annexin A5 Homo sapiens 80-89 25054024-0 2014 Inhibition of COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a chlorogenic acid ester saponin. Saponins 111-118 cytochrome c oxidase II, mitochondrial Mus musculus 14-19 25059722-3 2014 Previous studies have indicated that dietary sea cucumber saponin (SCS) could improve glucose and lipid metabolism of rodent. Saponins 58-65 sepia Mus musculus 45-48 23828910-1 2014 Jujuboside B (JuB) is a main bioactive saponin constituent of Ziziphi Spinosae Semen, which is a traditional herb for the treatment of insomnia and anxiety. Saponins 39-46 ajuba LIM protein Rattus norvegicus 0-12 23828910-1 2014 Jujuboside B (JuB) is a main bioactive saponin constituent of Ziziphi Spinosae Semen, which is a traditional herb for the treatment of insomnia and anxiety. Saponins 39-46 ajuba LIM protein Rattus norvegicus 14-17 24484214-9 2014 CONCLUSION: Panax notoginseng saponins possess excellent anti-OSF activity, and its mechanism may be related to its ability to inhibit the ANE-induced activation of PI3K/AKT, ERK/JNK/p38 MAPK, and TGFbeta/smad pathways. Saponins 30-38 mitogen-activated protein kinase 8 Homo sapiens 179-182 24484214-9 2014 CONCLUSION: Panax notoginseng saponins possess excellent anti-OSF activity, and its mechanism may be related to its ability to inhibit the ANE-induced activation of PI3K/AKT, ERK/JNK/p38 MAPK, and TGFbeta/smad pathways. Saponins 30-38 transforming growth factor beta 1 Homo sapiens 197-204 25165785-0 2014 The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3beta. Saponins 44-52 glycogen synthase kinase 3 beta Mus musculus 130-139 24856809-5 2014 As SGLT1 is found in high levels in brush-border membranes of intestinal epithelial cells, these findings demonstrate for the first time the potential of these saponins for inhibiting electrogenic glucose uptake in the gastrointestinal tract. Saponins 160-168 major facilitator superfamily domain containing 4B S homeolog Xenopus laevis 3-8 24854572-0 2014 Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kappaB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Saponins 37-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 111-120 24854572-0 2014 Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kappaB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Saponins 37-45 signal transducer and activator of transcription 1 Mus musculus 125-130 24854572-0 2014 Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kappaB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Saponins 37-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 149-153 24560910-4 2014 Ginsenoside Rg1 (Rg1) is a steroidal saponin abundantly contained in ginseng. Saponins 37-44 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 24105419-0 2014 Platycodi radix saponin inhibits alpha-glucosidase in vitro and modulates hepatic glucose-regulating enzyme activities in C57BL/KsJ-db/db mice. Saponins 16-23 sucrase isomaltase (alpha-glucosidase) Mus musculus 33-50 24105419-1 2014 This study investigated anti-diabetic activity of a concentrated saponin fraction from Platycodi radix (SK1) in C57BL/KsJ-db/db mice and its underlying mechanism. Saponins 65-72 skin antigen 1 Mus musculus 104-107 24754510-0 2014 Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway. Saponins 31-38 negative elongation factor complex member C/D, Th1l Mus musculus 96-99 24754510-0 2014 Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway. Saponins 31-38 heart and neural crest derivatives expressed 2 Mus musculus 101-104 25272846-12 2014 Compared with the LPS model group, total saponins of P. japonicus high, middle and low dose groups (0.1, 1, 10, 40 mg x L(-1)) could significantly reduce the secretion of NO, TNF-alpha, IL-1beta of LPS-induced RAW264. Saponins 41-49 tumor necrosis factor Mus musculus 175-184 25272846-12 2014 Compared with the LPS model group, total saponins of P. japonicus high, middle and low dose groups (0.1, 1, 10, 40 mg x L(-1)) could significantly reduce the secretion of NO, TNF-alpha, IL-1beta of LPS-induced RAW264. Saponins 41-49 interleukin 1 beta Mus musculus 186-194 24119161-0 2014 Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Saponins 12-19 thioredoxin 1 Mus musculus 76-89 24119161-15 2014 CONCLUSION: Panaxatriol saponin ameliorated liver injury by APAP through restoring the expression TRX-1 and inhibiting pro-caspase-12 decrease. Saponins 24-31 thioredoxin 1 Mus musculus 98-103 24754510-0 2014 Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway. Saponins 31-38 mitogen-activated protein kinase 1 Mus musculus 130-134 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 interleukin 1 complex Mus musculus 49-67 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 interleukin 2 Mus musculus 69-73 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 interferon gamma Mus musculus 82-98 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 tumor necrosis factor Mus musculus 103-136 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 interleukin 10 Mus musculus 175-180 24754510-7 2014 Tea saponin with OVA increased the expression of interleukin (IL)-1, IL-2, IL-12, interferon-gamma and tumor necrosis factor (TNF)-alpha and decreased the expression level of IL-10 and IL-8 in T-lymphocytes. Saponins 4-11 chemokine (C-X-C motif) ligand 15 Mus musculus 185-189 24754510-8 2014 Furthermore, tea saponin, in the presence of OVA, downregulated the MAPK signaling pathway via inhibition of IL-4, IL-8 and nuclear factor kappaB (NF-kappaB) in EL4 cells. Saponins 17-24 interleukin 4 Mus musculus 109-113 24754510-8 2014 Furthermore, tea saponin, in the presence of OVA, downregulated the MAPK signaling pathway via inhibition of IL-4, IL-8 and nuclear factor kappaB (NF-kappaB) in EL4 cells. Saponins 17-24 chemokine (C-X-C motif) ligand 15 Mus musculus 115-119 24754510-8 2014 Furthermore, tea saponin, in the presence of OVA, downregulated the MAPK signaling pathway via inhibition of IL-4, IL-8 and nuclear factor kappaB (NF-kappaB) in EL4 cells. Saponins 17-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 147-156 24754510-9 2014 Th1 cytokines enhancer and Th2 cytokines and NF-kappaB inhibitor, tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-alpha- and NF-kappaB-mediated regulation of MAPK signaling pathway. Saponins 70-77 negative elongation factor complex member C/D, Th1l Mus musculus 0-3 24754510-9 2014 Th1 cytokines enhancer and Th2 cytokines and NF-kappaB inhibitor, tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-alpha- and NF-kappaB-mediated regulation of MAPK signaling pathway. Saponins 70-77 heart and neural crest derivatives expressed 2 Mus musculus 27-30 24754510-9 2014 Th1 cytokines enhancer and Th2 cytokines and NF-kappaB inhibitor, tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-alpha- and NF-kappaB-mediated regulation of MAPK signaling pathway. Saponins 70-77 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-54 24754510-9 2014 Th1 cytokines enhancer and Th2 cytokines and NF-kappaB inhibitor, tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-alpha- and NF-kappaB-mediated regulation of MAPK signaling pathway. Saponins 70-77 tumor necrosis factor Mus musculus 177-186 24754510-9 2014 Th1 cytokines enhancer and Th2 cytokines and NF-kappaB inhibitor, tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-alpha- and NF-kappaB-mediated regulation of MAPK signaling pathway. Saponins 70-77 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 192-201 24963614-11 2014 These findings demonstrate that total steroid saponins exhibit promising neuroprotection effects against the transient focal ischemia-reperfusion cerebral injury in the rat experimental model and the underlying mechanisms might be mediated through inhibition of anti-edema as well as anti-oxidative effects by inactivation of NF-kappaB and ERK 1/2 signalling pathway. Saponins 46-54 mitogen activated protein kinase 3 Rattus norvegicus 340-347 24560910-4 2014 Ginsenoside Rg1 (Rg1) is a steroidal saponin abundantly contained in ginseng. Saponins 37-44 protein phosphatase 1, regulatory subunit 3A Mus musculus 17-20 24491258-1 2014 The present study was to investigate the effects and possible mechanisms of the total saponins from Dioscorea nipponica Makino (TSDN) against CCl4-induced hepato-toxicity in mice. Saponins 86-94 chemokine (C-C motif) ligand 4 Mus musculus 142-146 24530287-4 2014 In the present study, two known pennogenyl saponins (PS1 and PS2) were isolated from R. paridis axialis and identified by spectral techniques. Saponins 43-51 presenilin 1 Mus musculus 53-56 24530287-4 2014 In the present study, two known pennogenyl saponins (PS1 and PS2) were isolated from R. paridis axialis and identified by spectral techniques. Saponins 43-51 trefoil factor 1 Mus musculus 61-64 24117220-0 2014 Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng. Saponins 90-97 purinergic receptor P2Y12 Homo sapiens 9-14 24524879-3 2014 AIM OF STUDY: To evaluate the antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis (SAT) in experimental type 2 diabetic mellitus (T2DM) rats. Saponins 99-107 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 143-146 24597831-11 2014 CONCLUSIONS: RT saponins in n-butanol fraction might be a potential antioxidant candidate, as CCl4-induced oxidative stress has been found to be alleviated, which may be associated with the time dependent manner of n-butanol saponins in a low dose. Saponins 16-24 C-C motif chemokine ligand 4 Homo sapiens 94-98 24822411-6 2014 In addition, panaxatriol saponin Rf has displayed stronger disturbance effect on DMPC than Re and Rg1. Saponins 25-32 protein phosphatase 1 regulatory subunit 3A Homo sapiens 98-101 29403868-6 2014 It was found that the pharmacokinetic parameters of notoginsenoside R1, ginsenoside Rg1 and Rb1 represented a statistically significant difference (P<0.05) between the normal rats and the blood stasis rats after administration of total saponin from Sanqi (TSFS). Saponins 239-246 RB transcriptional corepressor 1 Rattus norvegicus 92-95 24291418-4 2014 In order to explain this phenomenon, we carried out research on the effects of Rhizoma Paridis Saponins on the activities of cytochrome p450 enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2E1 and CYP3A4. Saponins 95-103 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 149-155 24291418-4 2014 In order to explain this phenomenon, we carried out research on the effects of Rhizoma Paridis Saponins on the activities of cytochrome p450 enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2E1 and CYP3A4. Saponins 95-103 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 181-187 24165110-0 2014 Effects of Panax notoginseng saponin on alpha, beta, and gamma secretase involved in Abeta deposition in SAMP8 mice. Saponins 29-36 amyloid beta (A4) precursor protein Mus musculus 85-90 24428931-10 2014 Mechanistically, we found that failure of alum + LAg to protect mice was associated with elevated levels of IL-4, whereas both IL-4 and IL-10 levels were increased in saponin + LAg immunized mice. Saponins 167-174 interleukin 4 Mus musculus 127-131 24428931-10 2014 Mechanistically, we found that failure of alum + LAg to protect mice was associated with elevated levels of IL-4, whereas both IL-4 and IL-10 levels were increased in saponin + LAg immunized mice. Saponins 167-174 interleukin 10 Mus musculus 136-141 24428931-13 2014 CONCLUSIONS: These findings indicate that elevated levels of IL-4 may contribute to LAg vaccine failure, whereas combined elevation of IL-4 together with IL-10 exacerbated the disease as observed in saponin + LAg immunized mice. Saponins 199-206 interleukin 4 Mus musculus 135-139 24428931-13 2014 CONCLUSIONS: These findings indicate that elevated levels of IL-4 may contribute to LAg vaccine failure, whereas combined elevation of IL-4 together with IL-10 exacerbated the disease as observed in saponin + LAg immunized mice. Saponins 199-206 interleukin 10 Mus musculus 154-159 24269237-0 2014 Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC. Saponins 0-7 AKT serine/threonine kinase 1 Homo sapiens 108-111 24467548-4 2014 We observed that the total saponins of S. riparia could down-regulate renal mURAT1, resulting in the enhancement of urate excretion in the kidney of hyperuricemic mice. Saponins 27-35 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 76-82 25605200-0 2014 Steroidal saponins from Paris polyphylla suppress adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMP-2 and MMP-9. Saponins 10-18 matrix metallopeptidase 2 Homo sapiens 135-140 25605200-0 2014 Steroidal saponins from Paris polyphylla suppress adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMP-2 and MMP-9. Saponins 10-18 matrix metallopeptidase 9 Homo sapiens 145-150 25041018-0 2014 Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition. Saponins 0-8 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 100-104 25041018-0 2014 Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition. Saponins 0-8 signal transducer and activator of transcription 3 Homo sapiens 120-125 24761846-1 2014 Ginsenoside Rg1 is one effective anticancer and antioxidant constituent of total saponins of Panax ginseng (TSPG), which has been shown to have various pharmacological effects. Saponins 81-89 protein phosphatase 1 regulatory subunit 3A Homo sapiens 12-15 24384406-4 2014 Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1beta-treated SW1353 cells at non-cytotoxic concentrations (1-50 muM). Saponins 21-29 interleukin 1 beta Homo sapiens 118-126 24384406-4 2014 Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1beta-treated SW1353 cells at non-cytotoxic concentrations (1-50 muM). Saponins 21-29 latexin Homo sapiens 186-189 24062182-2 2014 We earlier showed that GPI-0100, a semi-synthetic saponin derivative with amphiphilic structure, significantly stimulates the immunogenicity and protective efficacy of influenza subunit vaccine administered via a systemic route. Saponins 50-57 glucose-6-phosphate isomerase 1 Mus musculus 23-26 24117220-0 2014 Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng. Saponins 90-97 AKT interacting protein Homo sapiens 83-86 24117220-9 2014 KEY RESULTS: Among the saponins examined, Ft1 was the most potent procoagulant and induced dose-dependent platelet aggregation. Saponins 23-31 AKT interacting protein Homo sapiens 42-45 24771377-4 2014 Saponins promoted the maturation of human peripheral blood dendritic cells, which was proven by high expression of CD83 (terminal differentiation marker) and CD86 (bone-stimulating molecule) and of HLA-DR and HLA-ABC molecules on the cell membrane. Saponins 0-8 CD83 molecule Homo sapiens 115-119 24771377-4 2014 Saponins promoted the maturation of human peripheral blood dendritic cells, which was proven by high expression of CD83 (terminal differentiation marker) and CD86 (bone-stimulating molecule) and of HLA-DR and HLA-ABC molecules on the cell membrane. Saponins 0-8 CD86 molecule Homo sapiens 158-162 24902809-8 2014 The expression levels of the c-fos gene in Group B were significantly higher than that in groups A and C, and expression levels of the Bax gene in Group A were significantly lower than that in groups B and C. CONCLUSION: The saponin extract of RP can inhibit oxidative stress, downregulate the levels of c-fos and Bax gene expression, and inhibit apoptosis in the retina after photocoagulation. Saponins 225-232 apoptosis regulator BAX Oryctolagus cuniculus 135-138 24902809-8 2014 The expression levels of the c-fos gene in Group B were significantly higher than that in groups A and C, and expression levels of the Bax gene in Group A were significantly lower than that in groups B and C. CONCLUSION: The saponin extract of RP can inhibit oxidative stress, downregulate the levels of c-fos and Bax gene expression, and inhibit apoptosis in the retina after photocoagulation. Saponins 225-232 apoptosis regulator BAX Oryctolagus cuniculus 314-317 24341702-0 2014 Saponins from the roots of Platycodon grandiflorum suppresses TGFbeta1-induced epithelial-mesenchymal transition via repression of PI3K/Akt, ERK1/2 and Smad2/3 pathway in human lung carcinoma A549 cells. Saponins 0-8 transforming growth factor beta 1 Homo sapiens 62-70 24818251-0 2014 Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo. Saponins 18-26 reticulon 4 Rattus norvegicus 81-87 24818251-0 2014 Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo. Saponins 18-26 reticulon 4 receptor Rattus norvegicus 89-92 24818251-4 2014 We found that the expression of Nogo-A, NgR and p75 of rats receiving MCAO surgery increased on the 7th day, reached a peak on the 14th or 28th day and maintained high levels and Panax notoginseng saponins significantly decreased these expressions. Saponins 197-205 reticulon 4 Rattus norvegicus 32-38 24818251-4 2014 We found that the expression of Nogo-A, NgR and p75 of rats receiving MCAO surgery increased on the 7th day, reached a peak on the 14th or 28th day and maintained high levels and Panax notoginseng saponins significantly decreased these expressions. Saponins 197-205 reticulon 4 receptor Rattus norvegicus 40-43 24818251-4 2014 We found that the expression of Nogo-A, NgR and p75 of rats receiving MCAO surgery increased on the 7th day, reached a peak on the 14th or 28th day and maintained high levels and Panax notoginseng saponins significantly decreased these expressions. Saponins 197-205 nerve growth factor receptor Rattus norvegicus 48-51 24558305-4 2014 Ginsenoside-Rh2, a ginseng saponin isolated from the root of Panax ginseng, has been suggested to have potential as an anticancer agent, but the underlying mechanisms remain elusive. Saponins 27-34 Rh associated glycoprotein Homo sapiens 12-15 24955212-0 2014 Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway. Saponins 12-20 AKT serine/threonine kinase 1 Rattus norvegicus 103-106 24955212-0 2014 Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway. Saponins 12-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 111-115 24669284-0 2014 Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. Saponins 0-8 forkhead box O3 Rattus norvegicus 91-97 24669284-0 2014 Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. Saponins 0-8 NFE2 like bZIP transcription factor 2 Rattus norvegicus 102-106 24669284-9 2014 By activating FOXO3a and Nrf2 pathways, saponins increase their downstream multiple antioxidants expression and function, at least in part contributing to the protection on the D-galactose-induced aging in rats. Saponins 40-48 forkhead box O3 Rattus norvegicus 14-20 24669284-9 2014 By activating FOXO3a and Nrf2 pathways, saponins increase their downstream multiple antioxidants expression and function, at least in part contributing to the protection on the D-galactose-induced aging in rats. Saponins 40-48 NFE2 like bZIP transcription factor 2 Rattus norvegicus 25-29 24341702-0 2014 Saponins from the roots of Platycodon grandiflorum suppresses TGFbeta1-induced epithelial-mesenchymal transition via repression of PI3K/Akt, ERK1/2 and Smad2/3 pathway in human lung carcinoma A549 cells. Saponins 0-8 AKT serine/threonine kinase 1 Homo sapiens 136-139 24341702-0 2014 Saponins from the roots of Platycodon grandiflorum suppresses TGFbeta1-induced epithelial-mesenchymal transition via repression of PI3K/Akt, ERK1/2 and Smad2/3 pathway in human lung carcinoma A549 cells. Saponins 0-8 mitogen-activated protein kinase 3 Homo sapiens 141-147 24341702-0 2014 Saponins from the roots of Platycodon grandiflorum suppresses TGFbeta1-induced epithelial-mesenchymal transition via repression of PI3K/Akt, ERK1/2 and Smad2/3 pathway in human lung carcinoma A549 cells. Saponins 0-8 SMAD family member 3 Homo sapiens 152-159 24458001-0 2014 Panax notoginseng saponins improve erectile function through attenuation of oxidative stress, restoration of Akt activity and protection of endothelial and smooth muscle cells in diabetic rats with erectile dysfunction. Saponins 18-26 AKT serine/threonine kinase 1 Rattus norvegicus 109-112 24123538-0 2014 The effects of Panax notoginseng saponins (PNS) on the activities of "rat" CYP2C9, CYP2D6 and CYP3A4. Saponins 33-41 cytochrome P450, family 2, subfamily d, polypeptide 3 Rattus norvegicus 83-89 24084294-9 2013 A significant reduction in the cell membrane cholesterol content was noted for those saponins who showed membrane toxicity (IC50 <60 muM). Saponins 85-93 latexin Homo sapiens 136-139 24269908-3 2013 The MS/MS transitions of the triterpenoidal saponins: m/z 911.4 603.2, 749.4 471.3, 895.6 733.2, 733.5 455.3, and 579.3 371.1 were monitored for B3, BD, B7 and B10, B11 and internal standard (Forsythin), respectively. Saponins 44-52 ectonucleotide pyrophosphatase/phosphodiesterase 3 Rattus norvegicus 145-168 24344979-8 2014 Upon incubation of mate extract with StPPO, phenolic compounds disappeared completely and saponins remained. Saponins 90-98 catechol oxidase B, chloroplastic Solanum tuberosum 37-42 24084294-11 2013 Saponins with little influence on the cell membrane (IC50 >100 muM) insignificantly altered the cell membrane cholesterol content. Saponins 0-8 latexin Homo sapiens 66-69 24084294-14 2013 In these experiments ECV-304 cells were either incubated with (3)H-cholesterol or with (3)H-cholesterol and 5 muM saponin. Saponins 114-121 latexin Homo sapiens 110-113 23578622-0 2013 Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells. Saponins 0-8 sirtuin 1 Homo sapiens 87-92 24224098-0 2013 Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of beta -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity. Saponins 4-12 glucuronidase, beta Rattus norvegicus 92-111 23725454-7 2013 Additional screening using sets of saponin- and triazine-based compounds was undertaken to further validate this assay, which led to the discovery of triazine PP-II-A03 as a novel insulin mimetic. Saponins 35-42 insulin Homo sapiens 180-187 24224098-8 2013 Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of beta -glucuronidase in rats, while the expression of COX-2 protein and PGE2 level were not affected. Saponins 65-73 glucuronidase, beta Rattus norvegicus 123-142 24224098-10 2013 Soybean saponins were effective in inhibiting colon cancer by downregulating the activity of beta -glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level. Saponins 8-16 glucuronidase, beta Rattus norvegicus 93-112 24233437-6 2013 Also, saponin fractions increased effectively intracellular antioxidant enzyme activities including catalase, glutathione peroxidase and superoxide dismutase in H2O2- treated HepG2 hepatoma cells. Saponins 6-13 catalase Homo sapiens 100-108 23827777-12 2013 Also, glutathione and superoxide dismutase (SOD)-levels were restored towards normalcy in the liver of CCl4-treated rats, indicating the hepatoprotective role of NPW, which was found to contain a fair amount of flavonoids, phenolics, and saponin constituents. Saponins 238-245 C-C motif chemokine ligand 4 Rattus norvegicus 103-107 23578622-0 2013 Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells. Saponins 0-8 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 111-139 23554136-0 2013 Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-kappaB p65ser(311) signaling via IkappaB-alpha and GSK-3beta reduced phosphorylation. Saponins 24-32 synaptotagmin 1 Rattus norvegicus 123-126 23554136-0 2013 Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-kappaB p65ser(311) signaling via IkappaB-alpha and GSK-3beta reduced phosphorylation. Saponins 24-32 NFKB inhibitor alpha Rattus norvegicus 149-162 23554136-0 2013 Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-kappaB p65ser(311) signaling via IkappaB-alpha and GSK-3beta reduced phosphorylation. Saponins 24-32 glycogen synthase kinase 3 beta Rattus norvegicus 167-176 23554136-6 2013 YMT and mate saponins reduced the expression of proinflammatory molecules COX-2 and iNOS with concomitant reduction in p-p65 (P < 0.05). Saponins 13-21 cytochrome c oxidase II, mitochondrial Rattus norvegicus 74-79 23554136-6 2013 YMT and mate saponins reduced the expression of proinflammatory molecules COX-2 and iNOS with concomitant reduction in p-p65 (P < 0.05). Saponins 13-21 nitric oxide synthase 2 Rattus norvegicus 84-88 23554136-6 2013 YMT and mate saponins reduced the expression of proinflammatory molecules COX-2 and iNOS with concomitant reduction in p-p65 (P < 0.05). Saponins 13-21 synaptotagmin 1 Rattus norvegicus 121-124 23554136-7 2013 Immunohistochemical analysis of the formalin-fixed middle colons showed that YMT and mate saponins reduced the expression of p-p65(ser311) by 45.7% and 43.1%, respectively, in comparison to the control (P < 0.05). Saponins 90-98 synaptotagmin 1 Rattus norvegicus 127-130 24146467-0 2013 Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences. Saponins 18-25 trans-2,3-enoyl-CoA reductase Homo sapiens 26-30 23499166-0 2013 Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. Saponins 12-20 coagulation factor II, thrombin Homo sapiens 63-71 23499166-2 2013 To determine the effect of its secondary plant metabolites on the endothelium, phenolic compounds and saponins from Butcher"s broom were isolated from a methanolic extract, and their activity on the thrombin-induced hyperpermeability of human microvascular endothelial cells (HMEC-1) was investigated in vitro. Saponins 102-110 coagulation factor II, thrombin Homo sapiens 199-207 23499166-7 2013 The highest activities were observed for the spirostanol saponins 5 and 8 and for esculin (4) at 10muM, and these compounds resulted in a reduction of the thrombin-induced hyperpermeability to 41.9%, 42.6% and 53.3%, respectively. Saponins 57-65 coagulation factor II, thrombin Homo sapiens 155-163 23737876-1 2013 Saikosaponin A (SSA) is a major triterpenoid saponin isolated from Radix bupleuri (RB), a widely used Chinese traditional medicine to treat various inflammation-related diseases. Saponins 5-12 tripartite motif-containing 21 Mus musculus 16-19 23399642-2 2013 We used mesenchymally transformed, E-cadherin-negative MDA-MB-231 breast carcinoma cells in a natural product screen and determined that the triterpenoid saponin sarasinoside A1 inhibited their invasion and the invasion of a number of other tumor cell lines. Saponins 154-161 cadherin 1 Homo sapiens 35-45 24146467-2 2013 Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. Saponins 39-46 trans-2,3-enoyl-CoA reductase Homo sapiens 47-51 24146480-0 2013 Effect of Paris saponin on antitumor and immune function in U14 tumor-bearing mice. Saponins 16-23 small nucleolar RNA, C/D box 14C Mus musculus 60-63 24146480-2 2013 MTT assay was used to examine the effect of Paris saponin on U14 cell proliferatiosn in vitro; the ascites tumor model of U14 cervical cancer was established to observe the effect of Paris saponin on inhibition of the tumor and on survival time of mice; and serum IL-4 and IFN-gamma levels in tumor-bearing mice were detected. Saponins 50-57 small nucleolar RNA, C/D box 14C Mus musculus 61-64 23315199-7 2013 A combined pharmacophore- and docking-based virtual screening was performed to identify several saponins as potential inhibitors for NMMHC IIA. Saponins 96-104 myosin heavy chain 9 Homo sapiens 133-142 23444389-4 2013 The aim of this study was to investigate whether ginseng total saponins (GTS) exerts its antidiabetic effects via modulating GLP1 release. Saponins 63-71 glucagon like peptide 1 receptor Homo sapiens 125-129 23443329-3 2013 In this study, we show that the treatment of prostate cancer cells with saponins extracted from P. grandiflorum (SPG) inhibits cell proliferation in a dose-dependent manner. Saponins 72-80 SPG16 Homo sapiens 113-116 23700798-0 2013 alpha-Glucosidase and alpha-amylase inhibitory activities of saponins from traditional Chinese medicines in the treatment of diabetes mellitus. Saponins 61-69 sucrase-isomaltase Homo sapiens 0-17 23700798-5 2013 The results revealed that saponins 2, 3, 4 (IC50: 0.83 +/- 0.05 microM for BSG and IC50: 0.72 +/- 0.03 microM for SCG), 5, 6, 7, 9, 10, 11 and 12 (IC50: 1.07 +/- 0.04 micro.M for BSG and IC50: 0.93 +/- 0.05 micro.M for SCG) showed alpha-glucosidase inhibitory activities, while 2, 3, 4 (IC50: 0.93 +/- 0.04 micro.M for PPA), 5, 6, 7, 9, 10, 11 and 12 (IC50: 1.02 +/- 0.03 micro.M for PPA) possessed significant alpha-amylase inhibitory activities. Saponins 26-34 sucrase-isomaltase Homo sapiens 231-248 23944037-0 2013 [Effect of Panax notoginseng saponins on expressions of MMP-13 and TIMP-1 in rats with hepatic fibrosis]. Saponins 29-37 matrix metallopeptidase 13 Rattus norvegicus 56-62 23847952-0 2013 [Effects of sapindus saponins on inflammatory response mediated by Ang II/p38MAPK pathway and cardiac hypertrophy in spontaneously hypertensive rats]. Saponins 21-29 angiogenin Rattus norvegicus 67-70 23847952-6 2013 RESULT: Sapindus saponins reduced LVMI, and blocked the expression level of Ang II, AT1R, p-p38MAPK, VEGF and hs-CRP in myocardial tissue. Saponins 17-25 angiotensinogen Rattus norvegicus 76-82 23847952-6 2013 RESULT: Sapindus saponins reduced LVMI, and blocked the expression level of Ang II, AT1R, p-p38MAPK, VEGF and hs-CRP in myocardial tissue. Saponins 17-25 angiotensin II receptor, type 1a Rattus norvegicus 84-88 23847952-6 2013 RESULT: Sapindus saponins reduced LVMI, and blocked the expression level of Ang II, AT1R, p-p38MAPK, VEGF and hs-CRP in myocardial tissue. Saponins 17-25 vascular endothelial growth factor A Rattus norvegicus 101-105 23944037-0 2013 [Effect of Panax notoginseng saponins on expressions of MMP-13 and TIMP-1 in rats with hepatic fibrosis]. Saponins 29-37 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 67-73 23944037-1 2013 OBJECTIVE: To investigate the effect of Panax notoginseng saponins (PNS) on the expressions of matrix metalloproteinase (MMP)-13 and its tissue inhibitor of metalloproteinase (TIMP)-1 in carbon tetrachloride (CCl4)-induced hepatic fibrosis rats, and explore the possible mechanism of PNS"s effect against hepatic fibrosis. Saponins 58-66 C-C motif chemokine ligand 4 Rattus norvegicus 209-213 22821055-0 2013 Saponin-rich fraction from Clematis chinensis Osbeck roots protects rabbit chondrocytes against nitric oxide-induced apoptosis via preventing mitochondria impairment and caspase-3 activation. Saponins 0-7 caspase-3 Oryctolagus cuniculus 170-179 24146480-3 2013 The Paris saponin showed significant inhibitory effect on growth of cervical cancer U14 cells both in vitro and in vivo, prolonged the survival time of mice, increased the serum IFN-gamma level of tumor-bearing mice, and reduced the serum IL-4 level. Saponins 10-17 small nucleolar RNA, C/D box 14C Mus musculus 84-87 24146480-3 2013 The Paris saponin showed significant inhibitory effect on growth of cervical cancer U14 cells both in vitro and in vivo, prolonged the survival time of mice, increased the serum IFN-gamma level of tumor-bearing mice, and reduced the serum IL-4 level. Saponins 10-17 interferon gamma Mus musculus 178-187 24146480-3 2013 The Paris saponin showed significant inhibitory effect on growth of cervical cancer U14 cells both in vitro and in vivo, prolonged the survival time of mice, increased the serum IFN-gamma level of tumor-bearing mice, and reduced the serum IL-4 level. Saponins 10-17 interleukin 4 Mus musculus 239-243 24146480-4 2013 The Paris saponin can inhibit U14 cell growth and prolong survival time of mice; it is speculated that the Paris saponin may express its anti-tumor activity by improving the body"s immune system. Saponins 10-17 small nucleolar RNA, C/D box 14C Mus musculus 30-33 24146480-4 2013 The Paris saponin can inhibit U14 cell growth and prolong survival time of mice; it is speculated that the Paris saponin may express its anti-tumor activity by improving the body"s immune system. Saponins 113-120 small nucleolar RNA, C/D box 14C Mus musculus 30-33 23371459-0 2013 Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells. Saponins 18-26 mitogen-activated protein kinase kinase 7 Homo sapiens 90-93 23439553-0 2013 A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1. Saponins 12-19 SUN family protein UTH1 Saccharomyces cerevisiae S288C 112-116 23125221-1 2013 The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells. Saponins 15-22 Rh associated glycoprotein Homo sapiens 35-38 23152132-3 2013 Ginsenoside Rh2, one of the components in ginseng saponin, has been shown to have anti-proliferative effect on human NSCLC cells and is being studied as a therapeutic drug for NSCLC. Saponins 50-57 Rh associated glycoprotein Homo sapiens 12-15 23371459-0 2013 Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells. Saponins 18-26 mitogen-activated protein kinase 1 Homo sapiens 95-98 23404227-10 2013 The gene expression of TGFB1 and collagen I in the renal samples was significantly suppressed in the low- and high-dose saponin groups compared with that in the control group. Saponins 120-127 transforming growth factor, beta 1 Rattus norvegicus 23-28 23371459-0 2013 Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells. Saponins 18-26 AKT serine/threonine kinase 1 Homo sapiens 100-103 23371459-0 2013 Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells. Saponins 18-26 glutaminyl-tRNA amidotransferase subunit QRSL1 Homo sapiens 131-135 23371459-1 2013 OBJECTIVE: To investigate the effects of panax notoginseng saponins (PNS) on expression, regulation and phosphorylation of multiple protein kinases in mitogen activated protein kinase (MAPK) intracellular signal pathway and GATA transcription factors in hematopoietic cells, so as to explore its mechanism of proliferation and differentiation activity on hematopoiesis. Saponins 59-67 mitogen-activated protein kinase 3 Homo sapiens 185-189 23371459-1 2013 OBJECTIVE: To investigate the effects of panax notoginseng saponins (PNS) on expression, regulation and phosphorylation of multiple protein kinases in mitogen activated protein kinase (MAPK) intracellular signal pathway and GATA transcription factors in hematopoietic cells, so as to explore its mechanism of proliferation and differentiation activity on hematopoiesis. Saponins 59-67 glutaminyl-tRNA amidotransferase subunit QRSL1 Homo sapiens 224-228 23956765-0 2013 Panax Quinquefolius Saponin of Stem and Leaf Attenuates Intermittent High Glucose-Induced Oxidative Stress Injury in Cultured Human Umbilical Vein Endothelial Cells via PI3K/Akt/GSK-3 beta Pathway. Saponins 20-27 AKT serine/threonine kinase 1 Homo sapiens 174-177 23297776-5 2013 In addition, several polyphenolic compounds, such as isoflavones, saponins, phenolic acids, etc., impart bitter and astringent tastes to SPI. Saponins 66-74 chromogranin A Homo sapiens 137-140 24080960-0 2013 Panax notoginseng saponins promote endothelial progenitor cell mobilization and attenuate atherosclerotic lesions in apolipoprotein E knockout mice. Saponins 18-26 apolipoprotein E Mus musculus 117-133 23956765-0 2013 Panax Quinquefolius Saponin of Stem and Leaf Attenuates Intermittent High Glucose-Induced Oxidative Stress Injury in Cultured Human Umbilical Vein Endothelial Cells via PI3K/Akt/GSK-3 beta Pathway. Saponins 20-27 glycogen synthase kinase 3 beta Homo sapiens 178-188 24191167-7 2013 These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor. Saponins 134-142 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-89 24191167-6 2013 We found that COX-2/PGE2 signaling pathway, which plays key roles in the development of cancer, is involved in the antitumor activities of these saponins. Saponins 145-153 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 22978695-3 2013 The isolated saponins were evaluated for their in vitro cytotoxicity against A549, LAC and Hela human cancer cell lines, which demonstrated that only compound 1 possessed significant cytotoxic activity with IC50 values of 3.70, 5.70 and 3.64 microM, respectively. Saponins 13-21 lactase Homo sapiens 83-86 24191167-7 2013 These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor. Saponins 50-58 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-89 23573301-5 2013 rLiHyp1 plus saponin vaccinated mice showed a high and specific production of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation with the recombinant protein. Saponins 13-20 interferon gamma Mus musculus 78-87 23063465-1 2013 Ginsenoside Rg1, a steroidal saponin of high abundance in ginseng, possesses the neuroprotective effects. Saponins 29-36 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 23573301-5 2013 rLiHyp1 plus saponin vaccinated mice showed a high and specific production of IFN-gamma, IL-12, and GM-CSF after in vitro stimulation with the recombinant protein. Saponins 13-20 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 100-106 23437404-2 2013 Alpha (alpha)-tomatine is the major saponin present in tomato (Lycopersicon esculentum) and we have previously reported that it suppresses tumor necrosis factor-alpha (TNF-alpha)-induced nuclear translocation of nuclear factor-kappa B (NF-kappaB) in androgen-independent prostate cancer PC-3 cells and also potently induces apoptosis of these cells. Saponins 36-43 tumor necrosis factor Homo sapiens 168-177 22704889-6 2012 Additionally, we evaluated the anti-type I allergy activity of the saponins with RBL-2H3 (Rat basophilic leukemia) cells by measuring the beta-hexosaminidase release inhibitory activity. Saponins 67-75 O-GlcNAcase Rattus norvegicus 138-157 23717139-1 2012 Ginsenoside Rp1 (G-Rp1) is a saponin derivate that provides anti-metastatic activities through inhibition of the NF-kappaB pathway. Saponins 29-36 retinitis pigmentosa 1 (human) Mus musculus 12-15 23717139-1 2012 Ginsenoside Rp1 (G-Rp1) is a saponin derivate that provides anti-metastatic activities through inhibition of the NF-kappaB pathway. Saponins 29-36 retinitis pigmentosa 1 (human) Mus musculus 19-22 22923196-4 2012 Among them, compounds 1-4 are the first spirostanol saponins with a peroxy group located between C-5 and C-8 of the aglycone. Saponins 52-60 complement C5 Homo sapiens 97-100 22923196-4 2012 Among them, compounds 1-4 are the first spirostanol saponins with a peroxy group located between C-5 and C-8 of the aglycone. Saponins 52-60 homeobox C8 Homo sapiens 105-108 23270239-7 2012 The qingxin kaiqiao formula group and the saponin group showed a decrease in the expressions of Caspase-3, Abeta and betaAPP in cerebral cortex and hippocampus area, displaying notable differences (P < 0.01, P < 0.05) compared with the control group. Saponins 42-49 caspase 3 Rattus norvegicus 96-105 23270239-7 2012 The qingxin kaiqiao formula group and the saponin group showed a decrease in the expressions of Caspase-3, Abeta and betaAPP in cerebral cortex and hippocampus area, displaying notable differences (P < 0.01, P < 0.05) compared with the control group. Saponins 42-49 amyloid beta precursor protein Rattus norvegicus 107-112 23270239-8 2012 CONCLUSION: qingxin kaiqiao formula and saponin can obviously improve the learning and memory ability of AD rats with by decreasing the expression of Caspase-3, Abeta and betaAPP in cortex and hippocampus. Saponins 40-47 caspase 3 Rattus norvegicus 150-159 23270239-8 2012 CONCLUSION: qingxin kaiqiao formula and saponin can obviously improve the learning and memory ability of AD rats with by decreasing the expression of Caspase-3, Abeta and betaAPP in cortex and hippocampus. Saponins 40-47 amyloid beta precursor protein Rattus norvegicus 161-166 22992293-0 2012 Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. Saponins 11-19 vascular endothelial growth factor A Homo sapiens 33-67 22771629-1 2012 Notoginsenoside Ft1 (Ft1) is a saponin isolated from Panax notoginseng, which has been used traditionally for the treatment of trauma injuries in East Asia. Saponins 31-38 AKT interacting protein Homo sapiens 16-19 22771629-1 2012 Notoginsenoside Ft1 (Ft1) is a saponin isolated from Panax notoginseng, which has been used traditionally for the treatment of trauma injuries in East Asia. Saponins 31-38 AKT interacting protein Homo sapiens 21-24 22728095-1 2012 Saikosaponin a (SSa) and its epimer saikosaponin d (SSd) are major triterpenoid saponin derivatives from Radix bupleuri (RB), which has been long used in Chinese traditional medicine for treatment of various inflammation-related diseases. Saponins 5-12 tripartite motif-containing 21 Mus musculus 16-19 22771363-2 2012 Four semi-synthetic saponin derivatives, TSA1, TSA2, TSA3, and TSA4, were synthesized from TSA; two derivatives TSE1 and TSE2 were prepared from TSE. Saponins 20-27 lymphocyte antigen 6 complex, locus E Mus musculus 41-45 22683903-5 2012 AIM OF THE STUDY: The purpose of this study was to investigate whether Panax notoginseng saponins (PNS) attenuated atherosclerosis by inducing liver X receptor alpha (LXRalpha) expression and to elucidate the mechanisms responsible for the effects. Saponins 89-97 nuclear receptor subfamily 1, group H, member 3 Rattus norvegicus 167-175 22162298-0 2012 Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Saponins 29-37 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 59-65 22162298-0 2012 Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Saponins 29-37 cytochrome P450, family 2, subfamily d, polypeptide 4 Rattus norvegicus 75-81 23162908-1 2012 After searching the transcriptome dataset of Panax notoginseng, one unique sequence Pn02086 encoding UDP-glucosyltransferase (UGT), which may be involved in triterpene saponin biosynthesis, was discovered. Saponins 168-175 hydroquinone glucosyltransferase Medicago truncatula 101-124 23358207-0 2013 Triterpenoid saponins of Pulsatilla koreana root have inhibition effects of tumor necrosis factor-alpha secretion in lipopolysaccharide-induced RAW264.7 cells. Saponins 13-21 tumor necrosis factor Mus musculus 76-103 23285798-4 2012 In addition, the saponins showed moderate stimulatory effects on interleukin-2 production in PHA/PMA stimulated Jurkat E6.1 cells. Saponins 17-25 interleukin 2 Homo sapiens 65-78 23185771-1 2012 OBJECTIVE: To study the effects of Qingxin Kaiqiao Recipe (QKR) saponin on the expressions of Bax, Bcl-2, beta-amyloid (Abeta), and beta-amyloid precursor protein (betaAPP) in the cortex and hippocampus of Alzheimer"s disease (AD) rats. Saponins 64-71 BCL2 associated X, apoptosis regulator Rattus norvegicus 94-97 23185771-1 2012 OBJECTIVE: To study the effects of Qingxin Kaiqiao Recipe (QKR) saponin on the expressions of Bax, Bcl-2, beta-amyloid (Abeta), and beta-amyloid precursor protein (betaAPP) in the cortex and hippocampus of Alzheimer"s disease (AD) rats. Saponins 64-71 BCL2, apoptosis regulator Rattus norvegicus 99-104 23185771-1 2012 OBJECTIVE: To study the effects of Qingxin Kaiqiao Recipe (QKR) saponin on the expressions of Bax, Bcl-2, beta-amyloid (Abeta), and beta-amyloid precursor protein (betaAPP) in the cortex and hippocampus of Alzheimer"s disease (AD) rats. Saponins 64-71 amyloid beta precursor protein Rattus norvegicus 120-125 23185771-1 2012 OBJECTIVE: To study the effects of Qingxin Kaiqiao Recipe (QKR) saponin on the expressions of Bax, Bcl-2, beta-amyloid (Abeta), and beta-amyloid precursor protein (betaAPP) in the cortex and hippocampus of Alzheimer"s disease (AD) rats. Saponins 64-71 amyloid beta precursor protein Rattus norvegicus 132-162 23185771-18 2012 The escape latency was obviously postponed at day 3 -5, the platform crossing times decreased, the expression of Bcl-2 in the cortex and hippocampus decreased in the saponin group, showing statistical difference (P<0.05, P<0.01). Saponins 166-173 BCL2, apoptosis regulator Rattus norvegicus 113-118 21847688-5 2012 RESULTS: Platyconic acid (PA) most effectively increased insulin-stimulated glucose uptake in 3T3-L1 adipocytes, possibly in part by working as a peroxisome proliferator-activated receptors (PPAR)-gamma activator; however, none of the saponins improved glucose-stimulated insulin secretion in insulinoma cells. Saponins 235-243 peroxisome proliferator activated receptor gamma Mus musculus 191-195 23717127-3 2012 Therefore, in this study, we showed that RGSF containing 20(S)-protopanaxadiol type saponins inhibited nitric oxide production and attenuated the release of tumor necrotic factor (TNF)-alpha, interleukin (IL)-6, granulocyte monocyte colony stimulating factor (GMCSF), and macrophage chemo-attractant protein-1 in lipopolysaccharide (LPS) stimulated murine macrophage RAW264.7 cells. Saponins 84-92 tumor necrosis factor Mus musculus 157-190 23717127-3 2012 Therefore, in this study, we showed that RGSF containing 20(S)-protopanaxadiol type saponins inhibited nitric oxide production and attenuated the release of tumor necrotic factor (TNF)-alpha, interleukin (IL)-6, granulocyte monocyte colony stimulating factor (GMCSF), and macrophage chemo-attractant protein-1 in lipopolysaccharide (LPS) stimulated murine macrophage RAW264.7 cells. Saponins 84-92 interleukin 6 Mus musculus 192-210 23717127-3 2012 Therefore, in this study, we showed that RGSF containing 20(S)-protopanaxadiol type saponins inhibited nitric oxide production and attenuated the release of tumor necrotic factor (TNF)-alpha, interleukin (IL)-6, granulocyte monocyte colony stimulating factor (GMCSF), and macrophage chemo-attractant protein-1 in lipopolysaccharide (LPS) stimulated murine macrophage RAW264.7 cells. Saponins 84-92 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 212-258 23717127-3 2012 Therefore, in this study, we showed that RGSF containing 20(S)-protopanaxadiol type saponins inhibited nitric oxide production and attenuated the release of tumor necrotic factor (TNF)-alpha, interleukin (IL)-6, granulocyte monocyte colony stimulating factor (GMCSF), and macrophage chemo-attractant protein-1 in lipopolysaccharide (LPS) stimulated murine macrophage RAW264.7 cells. Saponins 84-92 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 260-265 22309811-4 2012 Certain plant secondary metabolites (saponins) were shown to increase the efficacy of a particular epidermal growth factor receptor (EGFR)-targeted toxin, paralleled by a tremendous decrease of side effects. Saponins 37-45 epidermal growth factor receptor Homo sapiens 99-131 22292787-5 2012 However, several saponins, including ginsenosides Ra3, Rb1, Rc, and Rd, and dioscin, are excreted slowly into the bile and in turn have significantly long elimination half lives (7-25 h in rats). Saponins 17-25 RB transcriptional corepressor 1 Rattus norvegicus 55-58 22309811-4 2012 Certain plant secondary metabolites (saponins) were shown to increase the efficacy of a particular epidermal growth factor receptor (EGFR)-targeted toxin, paralleled by a tremendous decrease of side effects. Saponins 37-45 epidermal growth factor receptor Homo sapiens 133-137 22309811-5 2012 This study was conducted in order to investigate the effects of substituting different toxin moieties fused to an EGF ligand binding domain on the augmentative ability of saponins for each against therapeutic potential of the saponin-mediated efficacy increase for different anti-tumor toxins targeting the EGFR. Saponins 171-179 epidermal growth factor receptor Homo sapiens 307-311 22309811-5 2012 This study was conducted in order to investigate the effects of substituting different toxin moieties fused to an EGF ligand binding domain on the augmentative ability of saponins for each against therapeutic potential of the saponin-mediated efficacy increase for different anti-tumor toxins targeting the EGFR. Saponins 171-178 epidermal growth factor receptor Homo sapiens 307-311 23717114-0 2012 Inhibition of TNF-alpha-mediated NF-kappaB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves. Saponins 101-109 tumor necrosis factor Homo sapiens 14-23 22457133-5 2012 BMP-4 expression was significantly increased in both liver fibrosis and HCC and saponin class of certain Chinese herbs could regulate its expression. Saponins 80-87 bone morphogenetic protein 4 Homo sapiens 0-5 25049609-1 2012 This study was conducted to determine the effects of dietary addition of tea saponins (TS) and soybean oil (SO) on fatty acid profile and gene expression of stearoyl-CoA desaturase (SCD) in longissimus dorsi (LD) muscle of growing lambs. Saponins 77-85 acyl-CoA desaturase Ovis aries 157-180 25049609-1 2012 This study was conducted to determine the effects of dietary addition of tea saponins (TS) and soybean oil (SO) on fatty acid profile and gene expression of stearoyl-CoA desaturase (SCD) in longissimus dorsi (LD) muscle of growing lambs. Saponins 77-85 acyl-CoA desaturase Ovis aries 182-185 21948936-7 2012 Finally, we found, using whole-cell patch-clamp recordings, that the action potential transmission in neurons within the somatosensory cortex was excited by Rb3 perfusion and blocked with Panax notoginseng total saponins extracted from leaves. Saponins 212-220 stathmin-like 4 Mus musculus 157-160 22159471-2 2012 Saikosaponin-d (SSD), a triterpene saponin extracted from Bupleurum falcatum L. (Umbelliferae), is known to exert inhibitory effects on COX-2 expression, together with inflammation and hepatic fibrosis. Saponins 5-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 136-141 22613987-0 2012 Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice. Saponins 19-27 MOK protein kinase Mus musculus 37-41 22178681-4 2012 The five oleanolic acid triterpenoid saponins used in this experiment suppressed N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation in a concentration-dependent manner. Saponins 37-45 formyl peptide receptor 1 Homo sapiens 122-126 22613987-0 2012 Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice. Saponins 19-27 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 61-70 22057058-2 2012 A series of different experiments were performed to investigate potential mechanisms of action by saponins with regard to ecdysteroid receptor (EcR) responsiveness, cell viability, cell membrane permeation, and induction of apoptosis with DNA fragmentation and caspase-3 like activity. Saponins 98-106 Ecdysone receptor Drosophila melanogaster 122-142 22862162-2 2012 In this study, we report the cytotoxic activity of the total saponins of Tupistra chinensis Baker (TST) against several carcinoma cell lines, including A549, MCF-7 and HeLa cells with the IC50 values of 4.11 mug/ml, 6.47 mug/ml and 7.78 mug/ml respectively. Saponins 61-69 thiosulfate sulfurtransferase Homo sapiens 99-102 23209812-2 2012 Saikosaponin a (SSa), a triterpene saponin derived from Bupleurum chinensis DC., has been demonstrated to have significant antiepileptic activity in a variety of epilepsy models in vivo. Saponins 5-12 tripartite motif containing 21 Homo sapiens 16-19 22880001-7 2012 This impairment was rescued by delivering exogenous cytochrome c to mitochondria via saponin-mediated plasma membrane permeabilization. Saponins 85-92 cytochrome c, somatic Homo sapiens 52-64 22138178-8 2012 Draining lymph node CD11c+ DCs acquire antigens more efficiently and become increasingly activated following ablation with saponin adjuvants relative to ablation alone. Saponins 123-130 integrin subunit alpha X Homo sapiens 20-25 22057058-6 2012 In general the data obtained provide evidence that the anti-ecdysteroid action by saponins is not based on a true antagonistic interaction with EcR signaling, but can be explained by a cytotoxic action due to permeation of the insect cell membrane. Saponins 82-90 Ecdysone receptor Drosophila melanogaster 144-147 23284901-0 2012 Enhancement of the immunogenicity and protective efficacy of a mucosal influenza subunit vaccine by the saponin adjuvant GPI-0100. Saponins 104-111 glucose-6-phosphate isomerase 1 Mus musculus 121-124 23284901-2 2012 Here, we used a murine challenge model to evaluate the adjuvant activity of GPI-0100, a saponin-derived adjuvant, on influenza subunit vaccine administered via the intranasal or the intrapulmonary route. Saponins 88-95 glucose-6-phosphate isomerase 1 Mus musculus 76-79 22745742-0 2012 Saponin inhibits hepatitis C virus propagation by up-regulating suppressor of cytokine signaling 2. Saponins 0-7 suppressor of cytokine signaling 2 Homo sapiens 64-98 22745742-5 2012 In addition, saponin potentiated IFN-alpha-induced anti-HCV activity. Saponins 13-20 interferon alpha 1 Homo sapiens 33-42 22745742-6 2012 Moreover, saponin exerted antiviral activity even in IFN-alpha resistant mutant HCVcc-infected cells. Saponins 10-17 interferon alpha 1 Homo sapiens 53-62 22745742-8 2012 We demonstrated that suppressor of cytokine signaling 2 (SOCS2) protein level was distinctively increased by saponin, which in turn resulted in inhibition of HCV replication. Saponins 109-116 suppressor of cytokine signaling 2 Homo sapiens 21-55 22745742-8 2012 We demonstrated that suppressor of cytokine signaling 2 (SOCS2) protein level was distinctively increased by saponin, which in turn resulted in inhibition of HCV replication. Saponins 109-116 suppressor of cytokine signaling 2 Homo sapiens 57-62 22745742-10 2012 These data imply that saponin inhibits HCV replication via SOCS2 signaling pathway. Saponins 22-29 suppressor of cytokine signaling 2 Homo sapiens 59-64 22734421-9 2012 CONCLUSION: Saponin from Tupistra chinensis showed beneficial effect on the prevention of mice from lipopolysaccharides-induced death, in which down regulation of IL-1beta and TNF-alpha expression might be involved. Saponins 12-19 interleukin 1 beta Mus musculus 163-171 22734421-9 2012 CONCLUSION: Saponin from Tupistra chinensis showed beneficial effect on the prevention of mice from lipopolysaccharides-induced death, in which down regulation of IL-1beta and TNF-alpha expression might be involved. Saponins 12-19 tumor necrosis factor Mus musculus 176-185 23983342-3 2012 A modify traditional method of crude saponins extraction was used to give the following percentage yields: WSA-2.74%, RAA-3.59%, LDC-1.62%, BFI-0.81% and LIP-1.57% respectively. Saponins 37-45 lipase A, lysosomal acid type Rattus norvegicus 154-159 21964931-2 2011 Ginsenoside-Rg1, a nontoxic saponin isolated from the rhizome of Panax ginseng, exhibits potent proangiogenic activity and has the potential to be developed as a new angiotherapeutic agent. Saponins 28-35 protein phosphatase 1 regulatory subunit 3A Homo sapiens 12-15 22057058-2 2012 A series of different experiments were performed to investigate potential mechanisms of action by saponins with regard to ecdysteroid receptor (EcR) responsiveness, cell viability, cell membrane permeation, and induction of apoptosis with DNA fragmentation and caspase-3 like activity. Saponins 98-106 Ecdysone receptor Drosophila melanogaster 144-147 22057058-2 2012 A series of different experiments were performed to investigate potential mechanisms of action by saponins with regard to ecdysteroid receptor (EcR) responsiveness, cell viability, cell membrane permeation, and induction of apoptosis with DNA fragmentation and caspase-3 like activity. Saponins 98-106 Death executioner caspase related to Apopain/Yama Drosophila melanogaster 261-270 22039103-3 2011 In the present study, using the gene co-expression analysis tool of Medicago truncatula, we found a strong correlation between CYP716A12 and beta-amyrin synthase (bAS), which encodes the enzyme responsible for the initial cyclization of 2,3-oxidosqualene to beta-amyrin (the basic structural backbone of most triterpenoid saponins). Saponins 322-330 beta-amyrin synthase Medicago truncatula 141-161 21963563-1 2011 AIM OF THE STUDY: To investigate the effect and mechanism of total saponins of panax ginseng (TSPG) on the damages of endothelium cells induced by Angiotensin II (AngII). Saponins 67-75 angiotensinogen Rattus norvegicus 163-168 21889336-0 2011 Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-kappaB inhibition and PPAR activation signal pathway. Saponins 25-33 nuclear factor kappa B subunit 1 Homo sapiens 74-83 21691763-8 2011 RESULTS: Saponin-treated animals showed increased SOD levels accompanied by decreased MDA, Scr and BUN levels (p < 0.05 vs. untreated controls); bcl-2 mRNA and protein levels were increased in transplanted kidney from treated animals, while bax mRNA and protein levels were decreased (p < 0.05 vs. untreated controls). Saponins 9-16 BCL2, apoptosis regulator Rattus norvegicus 148-153 21691763-8 2011 RESULTS: Saponin-treated animals showed increased SOD levels accompanied by decreased MDA, Scr and BUN levels (p < 0.05 vs. untreated controls); bcl-2 mRNA and protein levels were increased in transplanted kidney from treated animals, while bax mRNA and protein levels were decreased (p < 0.05 vs. untreated controls). Saponins 9-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 244-247 21816213-4 2011 Through the gelatin zymography assay, immunofluorescence analysis and western blot, saponins exhibited different levels of protein expression inhibition of MMP-1, -2, -3, -9 and -14. Saponins 84-92 matrix metallopeptidase 13 Mus musculus 156-181 21630021-0 2011 Manipulation of saponin biosynthesis by RNA interference-mediated silencing of beta-amyrin synthase gene expression in soybean. Saponins 16-23 beta-amyrin synthase Glycine max 79-99 21630021-2 2011 We now describe the modification of saponin biosynthesis by RNA interference (RNAi)-mediated gene silencing targeted to beta-amyrin synthase, a key enzyme in the synthesis of a common aglycon of soybean saponins. Saponins 36-43 beta-amyrin synthase Glycine max 120-140 21630021-2 2011 We now describe the modification of saponin biosynthesis by RNA interference (RNAi)-mediated gene silencing targeted to beta-amyrin synthase, a key enzyme in the synthesis of a common aglycon of soybean saponins. Saponins 203-211 beta-amyrin synthase Glycine max 120-140 21623512-3 2011 Chen (Araliaceae), which is a famous traditional Chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside ST-4. Saponins 171-178 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Homo sapiens 203-207 21995855-9 2011 RESULTS: Three saponin fractions and two individual ginsenosides exhibited the inhibitory effects on monocyte adhesion on TNF-alpha-activated HCAECs and expression of ICAM-1 and VCAM-1 at both mRNA and protein levels in vitro. Saponins 15-22 tumor necrosis factor Homo sapiens 122-131 21995855-11 2011 These inhibitory effect of saponin fractions maybe attribute partially to the suppression of the TNF-alpha-induced NF-kappaB activation. Saponins 27-34 tumor necrosis factor Homo sapiens 97-106 21995855-13 2011 Among the tested saponin fractions, PDS is the most potent saponin fraction against TNF-alpha-induced monocyte adhesion as well as the expression of adhesion molecules in vitro and in vivo. Saponins 17-24 tumor necrosis factor Homo sapiens 84-93 21995855-13 2011 Among the tested saponin fractions, PDS is the most potent saponin fraction against TNF-alpha-induced monocyte adhesion as well as the expression of adhesion molecules in vitro and in vivo. Saponins 59-66 tumor necrosis factor Homo sapiens 84-93 21619920-0 2011 Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes. Saponins 18-26 AKT serine/threonine kinase 1 Rattus norvegicus 81-84 25134766-2 2011 In the present study, we applied zebrafish for the first time in a metabolic study of notoginsenoside (R1), ginsenoside (Rg1) and ginsenoside (Rb1), which are saponins isolated from Panax notoginseng. Saponins 159-167 retinoblastoma 1 Danio rerio 143-146 22005258-0 2011 Saponins from the roots of Platycodon grandiflorum suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and NF-kappaB/AP-1-dependent signaling in HaCaT cells. Saponins 0-8 nuclear factor kappa B subunit 1 Homo sapiens 134-143 22005258-0 2011 Saponins from the roots of Platycodon grandiflorum suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and NF-kappaB/AP-1-dependent signaling in HaCaT cells. Saponins 0-8 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 144-148 22121814-0 2011 [Inhibition of glutathione-S-transferase by total saponins of Panax notoginseng and its kinetics analysis in liver of mice]. Saponins 50-58 hematopoietic prostaglandin D synthase Mus musculus 15-40 22121814-1 2011 OBJECTIVE: To study the inhibition of glutathione-s-transferase by total saponins of Panax notoginseng and its kinetics analysis in liver of mice. Saponins 73-81 hematopoietic prostaglandin D synthase Mus musculus 38-63 22121814-2 2011 METHOD: Mouse liver cytochyma enzyme was obtained by different velocity centrifugation, the mouse liver glutathione-S-transferase of michaelis constant (Km), maximum velocity (Vmax) and the inhibition of glutathione-S-transferase by total saponins of P. notoginseng of 50% inhibiting concentration (IC50), inhibition constant (KI, KIS), the type of inhibition were calculation by Lineweaver-Burk and the low of semi-effet-probit. Saponins 239-247 hematopoietic prostaglandin D synthase Mus musculus 104-129 22121814-2 2011 METHOD: Mouse liver cytochyma enzyme was obtained by different velocity centrifugation, the mouse liver glutathione-S-transferase of michaelis constant (Km), maximum velocity (Vmax) and the inhibition of glutathione-S-transferase by total saponins of P. notoginseng of 50% inhibiting concentration (IC50), inhibition constant (KI, KIS), the type of inhibition were calculation by Lineweaver-Burk and the low of semi-effet-probit. Saponins 239-247 hematopoietic prostaglandin D synthase Mus musculus 204-229 22121814-3 2011 RESULT: It was found that total saponins of P. notoginseng inhibited the glutathione-S-transferase activity with IC50 of 189.54 mg x L(-1). Saponins 32-40 hematopoietic prostaglandin D synthase Mus musculus 73-98 22121814-5 2011 Kinetics studies of total saponins of P. notoginseng on glutathione-S-transferase showed the inhibition were belong to mix-type with GSH and CDNB; the inhibition constant was 0.27 mg x L(-1) (KI), 0.68 mg x L(-1) (KIS) with GSH, and 0.21 mg x L(-1) (KI), 0.66 mg x L(-1) (KIS) with CDNB. Saponins 26-34 hematopoietic prostaglandin D synthase Mus musculus 56-81 22121814-6 2011 CONCLUSION: Total saponins of P. notoginseng strongly inhibited the glutathione-S-transferase activity. Saponins 18-26 hematopoietic prostaglandin D synthase Mus musculus 68-93 23717062-1 2011 Ginsenoside (G) Rp1 is a ginseng saponin derivative with anti-cancer and anti-inflammatory activities. Saponins 33-40 RP1 axonemal microtubule associated Homo sapiens 16-19 21490677-1 2011 20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, which is reported to be pro-apoptotic in some cells but anti-apoptotic in neuronal cells by regulating Akt signaling. Saponins 54-62 AKT serine/threonine kinase 1 Homo sapiens 167-170 21198552-1 2011 BACKGROUND AND PURPOSE: Kalopanaxsaponin A, a triterpenoid saponin isolated from Kalopanax pictus (family Araliaceae), potently inhibited nuclear factor-kappa B (NF-kappaB) activation in lipopolysaccharide (LPS)-stimulated peritoneal macrophages during a screening programme for anti-colitis agents from natural products. Saponins 33-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 162-171 21420464-2 2011 Here, the role of STAT3 pathway in the antitumor activity of an active ginseng saponin metabolite compound K (CK) was investigated in human multiple myeloma U266 cells. Saponins 79-86 signal transducer and activator of transcription 3 Homo sapiens 18-23 21198552-1 2011 BACKGROUND AND PURPOSE: Kalopanaxsaponin A, a triterpenoid saponin isolated from Kalopanax pictus (family Araliaceae), potently inhibited nuclear factor-kappa B (NF-kappaB) activation in lipopolysaccharide (LPS)-stimulated peritoneal macrophages during a screening programme for anti-colitis agents from natural products. Saponins 33-40 toll-like receptor 4 Mus musculus 207-210 21773070-0 2011 In vitro Effects of Selected Saponins on the Production and Release of Lysozyme Activity of Human Monocytic and Epithelial Cell Lines. Saponins 29-37 lysozyme Homo sapiens 71-79 21773070-2 2011 The purpose of the present study was to investigate whether in vitro exposure to saponins can affect the release and production of lysozyme activity in human monocytic cells THP-1, and in human epithelial cells HT-29. Saponins 81-89 lysozyme Homo sapiens 131-139 21773070-2 2011 The purpose of the present study was to investigate whether in vitro exposure to saponins can affect the release and production of lysozyme activity in human monocytic cells THP-1, and in human epithelial cells HT-29. Saponins 81-89 GLI family zinc finger 2 Homo sapiens 174-179 21773070-4 2011 Majority of the examined saponins were demonstrated to stimulate significantly the release of lysozyme activity of monocytes and epithelial cells after one hour treatment at non-toxic concentrations. Saponins 25-33 lysozyme Homo sapiens 94-102 21773070-5 2011 On the contrary, cells treated with saponins for longer periods up to 72 hours showed tendency to decrease in the secretion and production of lysozyme activity. Saponins 36-44 lysozyme Homo sapiens 142-150 21773070-7 2011 The results suggested positive contribution of some saponins to lysozyme release of monocytes and epithelial cells upon short exposure. Saponins 52-60 lysozyme Homo sapiens 64-72 21773070-8 2011 Furthermore, demonstrated ability of these saponins to enhance the release of lysozyme activity can present a new mechanism contribute to explaining important biological characteristics of saponins, including the antibacterial, antiviral, anti-inflammatory or immune-stimulating properties. Saponins 43-51 lysozyme Homo sapiens 78-86 21773070-8 2011 Furthermore, demonstrated ability of these saponins to enhance the release of lysozyme activity can present a new mechanism contribute to explaining important biological characteristics of saponins, including the antibacterial, antiviral, anti-inflammatory or immune-stimulating properties. Saponins 189-197 lysozyme Homo sapiens 78-86 20524959-1 2010 Ginsenoside Rb1, a major ingredient of ginseng saponins, can affect various brain functions, including learning and memory. Saponins 47-55 RB transcriptional corepressor 1 Homo sapiens 12-15 21673512-3 2011 The involvement of other relevant components of the saponin-related signaling routes, such as the Tumor Necrosis Factor(TNF)-alpha, the interleukin(IL)-6 and the Nuclear Transcription Factor-kB (NF-kappaB), has been highlighted in animal cells. Saponins 52-59 tumor necrosis factor Homo sapiens 98-130 21673512-3 2011 The involvement of other relevant components of the saponin-related signaling routes, such as the Tumor Necrosis Factor(TNF)-alpha, the interleukin(IL)-6 and the Nuclear Transcription Factor-kB (NF-kappaB), has been highlighted in animal cells. Saponins 52-59 interleukin 6 Homo sapiens 136-153 20847539-1 2011 Saponin is the generic name of steroid or triterpene glycosides, and the capacities of some saponins to stimulate both Th1 immune response and production of cytotoxic T cells are useful as vaccine components against intracellular pathogens. Saponins 92-100 negative elongation factor complex member C/D, Th1l Mus musculus 119-122 20704729-7 2010 Furthermore, a substantial amount of alphaS1-casein remained associated with microsomal or post-ER membranes after saponin permeabilisation in non-conservative conditions or carbonate extraction at pH11, all in the presence of DTT. Saponins 115-122 casein alpha s1 Rattus norvegicus 37-51 24250355-9 2011 Furthermore, we found these pennogenin steroidal saponins could induce HepG2 cells apoptosis at a concentration of 20 muM after 48 h treatment. Saponins 49-57 latexin Homo sapiens 118-121 20020492-0 2010 Epidermal growth factor receptor expression affects the efficacy of the combined application of saponin and a targeted toxin on human cervical carcinoma cells. Saponins 96-103 epidermal growth factor receptor Homo sapiens 0-32 20664949-0 2010 Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Saponins 11-19 mechanistic target of rapamycin kinase Homo sapiens 29-33 20664949-0 2010 Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Saponins 11-19 mitogen-activated protein kinase 1 Homo sapiens 38-41 20944999-0 2010 Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production. Saponins 89-96 interleukin 4 Mus musculus 190-194 20827341-8 2010 The ginseng total saponin exhibited a significant reversal in the nicotine-induced increase of TH and DBH mRNA expression, decreasing the mRNA levels of TH and DBH by 57.2% and 48.9%, respectively in PC12 cells. Saponins 18-25 dopamine beta-hydroxylase Rattus norvegicus 102-105 20602519-6 2010 Steroidal saponin added to defaunated ruminal fluid (dRF) or clarified ruminal fluid (cRF) was recovered completely from the mixture as saponin + sapogenin (99.1% and 100.6%, respectively), whereas saponin recovery from the supernatant of dRF was greatly reduced (P < 0.001) compared to that from supernatant of cRF (58.5 vs. 98.7%). Saponins 10-17 ventral veins lacking Drosophila melanogaster 53-56 20602519-6 2010 Steroidal saponin added to defaunated ruminal fluid (dRF) or clarified ruminal fluid (cRF) was recovered completely from the mixture as saponin + sapogenin (99.1% and 100.6%, respectively), whereas saponin recovery from the supernatant of dRF was greatly reduced (P < 0.001) compared to that from supernatant of cRF (58.5 vs. 98.7%). Saponins 10-17 ventral veins lacking Drosophila melanogaster 239-242 20602519-7 2010 Saponin recoveries from the supernatants of dRF and cRF did not differ between donor cattle fed or not fed Yucca schidigera saponin (59.2 vs. 57.3% and 98.4 vs. 99.3%, respectively). Saponins 0-7 ventral veins lacking Drosophila melanogaster 44-47 20827341-8 2010 The ginseng total saponin exhibited a significant reversal in the nicotine-induced increase of TH and DBH mRNA expression, decreasing the mRNA levels of TH and DBH by 57.2% and 48.9%, respectively in PC12 cells. Saponins 18-25 dopamine beta-hydroxylase Rattus norvegicus 160-163 21046759-0 2010 [Influence of astragalosides and Panax notoginseng saponins compatibility on MMP-9 and TIMP-1 after cerebral ischemia-reperfusion in mice]. Saponins 51-59 matrix metallopeptidase 9 Mus musculus 77-82 21046759-1 2010 OBJECTIVE: To investigate the effect of astragalosides (AST) and Panax notoginseng saponins (PNS) compatibility on the expression of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metal11oproteinase-1 (TIMP-1) after cerebral ischemia/reperfusion (I/R) injury in mice, to probe into its anti-ischemic brain injury protection mechanism. Saponins 83-91 matrix metallopeptidase 9 Mus musculus 162-167 21046759-1 2010 OBJECTIVE: To investigate the effect of astragalosides (AST) and Panax notoginseng saponins (PNS) compatibility on the expression of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metal11oproteinase-1 (TIMP-1) after cerebral ischemia/reperfusion (I/R) injury in mice, to probe into its anti-ischemic brain injury protection mechanism. Saponins 83-91 tissue inhibitor of metalloproteinase 1 Mus musculus 215-221 20435129-8 2010 CONCLUSIONS: PNS possess anti-hyperglycemic and anti-obese activities by improving insulin- and leptin sensitivity, and Rb1 is responsible for the anti-hyperglycemic effect among the five saponins in KK-Ay mice. Saponins 188-196 RB transcriptional corepressor 1 Mus musculus 120-123 20458170-3 2010 Because saponin extraction is specific for the non-autophagosome associated EGFP-LC3-I form of the protein, flow cytometry can be used to measure total fluorescence of saponin extracted HOS-EGFP-LC3 cells as a measure of the levels of autophagosome associated EGFP-LC3-II. Saponins 8-15 microtubule associated protein 1 light chain 3 alpha Homo sapiens 81-84 20458170-3 2010 Because saponin extraction is specific for the non-autophagosome associated EGFP-LC3-I form of the protein, flow cytometry can be used to measure total fluorescence of saponin extracted HOS-EGFP-LC3 cells as a measure of the levels of autophagosome associated EGFP-LC3-II. Saponins 168-175 microtubule associated protein 1 light chain 3 alpha Homo sapiens 195-198 20458170-3 2010 Because saponin extraction is specific for the non-autophagosome associated EGFP-LC3-I form of the protein, flow cytometry can be used to measure total fluorescence of saponin extracted HOS-EGFP-LC3 cells as a measure of the levels of autophagosome associated EGFP-LC3-II. Saponins 168-175 microtubule associated protein 1 light chain 3 alpha Homo sapiens 195-198 20053498-4 2010 The activation of c-Src, JAK1 and JAK2 implicated in STAT3 activation, were also suppressed by this saponin. Saponins 100-107 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 18-23 20053498-4 2010 The activation of c-Src, JAK1 and JAK2 implicated in STAT3 activation, were also suppressed by this saponin. Saponins 100-107 Janus kinase 1 Homo sapiens 25-29 20053498-4 2010 The activation of c-Src, JAK1 and JAK2 implicated in STAT3 activation, were also suppressed by this saponin. Saponins 100-107 Janus kinase 2 Homo sapiens 34-38 20053498-4 2010 The activation of c-Src, JAK1 and JAK2 implicated in STAT3 activation, were also suppressed by this saponin. Saponins 100-107 signal transducer and activator of transcription 3 Homo sapiens 53-58 20230881-0 2010 Molecular mechanism of endothelial nitric-oxide synthase activation by Platycodon grandiflorum root-derived saponins. Saponins 108-116 nitric oxide synthase 3 Homo sapiens 23-56 20346345-3 2010 Avicin G and avicin D were significantly more efficient than saponin in inducing cytotoxicity in PC3 human prostate cancer cells. Saponins 61-68 chromobox 8 Homo sapiens 97-100 20220105-3 2010 As characterized by infrared, mass, and nuclear magnetic resonance (NMR) spectral analyses, Mi-saponin A (MSA) was found to be the most potent component among a mixture of saponins. Saponins 172-180 thyroid peroxidase Homo sapiens 92-104 20554696-0 2010 Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3. Saponins 0-8 glutathione peroxidase 3 Mus musculus 120-124 20554696-0 2010 Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3. Saponins 0-8 superoxide dismutase 1, soluble Mus musculus 126-130 20554696-0 2010 Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3. Saponins 0-8 superoxide dismutase 3, extracellular Mus musculus 135-139 20220105-3 2010 As characterized by infrared, mass, and nuclear magnetic resonance (NMR) spectral analyses, Mi-saponin A (MSA) was found to be the most potent component among a mixture of saponins. Saponins 172-180 thyroid peroxidase Homo sapiens 106-109 20460744-6 2010 These results clearly indicate that the 3-O-beta-dglucopyranosiduronic moiety in saponins (glucuronide saponin) is essential for renin inhibition. Saponins 81-89 renin Homo sapiens 129-134 20460744-0 2010 Inhibition of human renin activity by saponins. Saponins 38-46 renin Homo sapiens 20-25 20460744-3 2010 In the present study, the effects of saponins and sapogenols on human renin activities were investigated. Saponins 37-45 renin Homo sapiens 70-75 20080229-3 2010 The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. Saponins 23-31 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 20080229-3 2010 The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. Saponins 23-31 tumor necrosis factor Homo sapiens 56-65 20080229-3 2010 The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. Saponins 23-31 GLI family zinc finger 2 Homo sapiens 156-161 20331853-9 2010 The calibration curves for the three saponins were linear over the concentration ranges 2.64-264 ng/mL (r2 = 0.9967, P = 0.003), 3.6-360 ng/mL (r2 = 0.9941, P = 0.004), and 18.7-1870 ng/mL (r2 = 0.9912, P = 0.004) for notoginsenoside R1, ginsenoside Rg1, and ginsenoside Rb1, respectively. Saponins 37-45 RB transcriptional corepressor 1 Canis lupus familiaris 271-274 20211032-0 2010 Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. Saponins 8-16 peroxisome proliferator activated receptor alpha Rattus norvegicus 87-96 20211032-0 2010 Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. Saponins 8-16 sterol regulatory element binding transcription factor 1 Rattus norvegicus 101-109 20460744-6 2010 These results clearly indicate that the 3-O-beta-dglucopyranosiduronic moiety in saponins (glucuronide saponin) is essential for renin inhibition. Saponins 81-88 renin Homo sapiens 129-134 19857566-0 2010 Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Saponins 12-20 thioredoxin 1 Rattus norvegicus 62-75 20606312-0 2010 The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Saponins 4-11 coagulation factor III, tissue factor Homo sapiens 141-154 20410593-0 2010 Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Saponins 12-19 matrix metallopeptidase 3 Mus musculus 116-142 21071835-1 2010 The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Saponins 42-49 renin Homo sapiens 53-58 21071835-2 2010 Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 microg/ml. Saponins 8-15 renin Homo sapiens 46-51 19615455-8 2009 DAW water extract, saponins fraction and akebia saponin D had the neuroprotective capacity to antagonize A beta(25-35)-induced cytotoxicity in PC 12 cells. Saponins 19-27 amyloid beta precursor protein Rattus norvegicus 105-111 20694680-4 2010 The optimal protocol employs saponin and Tween 20 both during the fixation and permeabilization steps, and we demonstrate that it is efficient for three anti-BCL11B antibodies covering distinctive BCL11B epitopes. Saponins 29-36 BAF chromatin remodeling complex subunit BCL11B Homo sapiens 158-164 20694680-4 2010 The optimal protocol employs saponin and Tween 20 both during the fixation and permeabilization steps, and we demonstrate that it is efficient for three anti-BCL11B antibodies covering distinctive BCL11B epitopes. Saponins 29-36 BAF chromatin remodeling complex subunit BCL11B Homo sapiens 197-203 20069911-3 2009 The triterpenoid saponins are mainly oleanolic type and hederagenin type, most of which are bidesmosidic saponins, substituted with oligosaccharide chains at both C-3 and C-28, and some are substituted with acetyl, caffeoyl, isoferuloyl, p-methoxy cinnamyl and 3,4-dimethoxy cinnamyl groups in the oligosaccharide chains. Saponins 17-25 complement C3 Homo sapiens 163-166 20518313-0 2010 [Effects of Panax notoginseng saponins on ACE2 and TNF-alpha in rats with post-myocardial infarction-ventricular remodeling]. Saponins 30-38 angiotensin I converting enzyme 2 Rattus norvegicus 42-46 20518313-0 2010 [Effects of Panax notoginseng saponins on ACE2 and TNF-alpha in rats with post-myocardial infarction-ventricular remodeling]. Saponins 30-38 tumor necrosis factor Rattus norvegicus 51-60 20518313-1 2010 OBJECTIVE: To research the effects of Panax notoginseng saponins (PNS) on angiotensin-converting enzymes 2 ( ACE2) and tumor necrosis factor-alpha (TNF-alpha) in rats with post-myocardial infarction ventricular remodeling. Saponins 56-64 angiotensin I converting enzyme 2 Rattus norvegicus 109-113 20518313-1 2010 OBJECTIVE: To research the effects of Panax notoginseng saponins (PNS) on angiotensin-converting enzymes 2 ( ACE2) and tumor necrosis factor-alpha (TNF-alpha) in rats with post-myocardial infarction ventricular remodeling. Saponins 56-64 tumor necrosis factor Rattus norvegicus 148-157 19735710-12 2009 In all doses used in the experiment, the steroidal saponins decreased aspartate aminotransferase (GOT), alanine aminotransferase (ALT) and alkaline phosphatase (AKP) in serum and increased reduced glutathione hormone (GSH), glutathione reductase (GR) and glutathione S-transferases (GST) in liver. Saponins 51-59 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 70-96 19735710-12 2009 In all doses used in the experiment, the steroidal saponins decreased aspartate aminotransferase (GOT), alanine aminotransferase (ALT) and alkaline phosphatase (AKP) in serum and increased reduced glutathione hormone (GSH), glutathione reductase (GR) and glutathione S-transferases (GST) in liver. Saponins 51-59 glutathione-disulfide reductase Rattus norvegicus 224-245 19735710-12 2009 In all doses used in the experiment, the steroidal saponins decreased aspartate aminotransferase (GOT), alanine aminotransferase (ALT) and alkaline phosphatase (AKP) in serum and increased reduced glutathione hormone (GSH), glutathione reductase (GR) and glutathione S-transferases (GST) in liver. Saponins 51-59 glutathione-disulfide reductase Rattus norvegicus 247-249 19781620-0 2009 Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora. Saponins 67-75 thymoma viral proto-oncogene 1 Mus musculus 24-27 19781620-4 2009 RESULTS: Western blotting revealed that incubation with saponins (100 microg/ml) and sapogenin (100 microg/ml) induced the phosphorylation of the phosphatidylinositol-3-kinase (PI3K) as well as of the downstream targets protein kinase B/Akt (at Ser473) and glycogen synthase kinase GSK-3 alpha/beta (at Ser21/9) in a time-dependent manner. Saponins 56-64 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 146-175 19781620-4 2009 RESULTS: Western blotting revealed that incubation with saponins (100 microg/ml) and sapogenin (100 microg/ml) induced the phosphorylation of the phosphatidylinositol-3-kinase (PI3K) as well as of the downstream targets protein kinase B/Akt (at Ser473) and glycogen synthase kinase GSK-3 alpha/beta (at Ser21/9) in a time-dependent manner. Saponins 56-64 thymoma viral proto-oncogene 1 Mus musculus 237-240 19781620-4 2009 RESULTS: Western blotting revealed that incubation with saponins (100 microg/ml) and sapogenin (100 microg/ml) induced the phosphorylation of the phosphatidylinositol-3-kinase (PI3K) as well as of the downstream targets protein kinase B/Akt (at Ser473) and glycogen synthase kinase GSK-3 alpha/beta (at Ser21/9) in a time-dependent manner. Saponins 56-64 glycogen synthase kinase 3 alpha Mus musculus 282-293 19781620-6 2009 Within 48 h saponins/sapogenin treatment further increased the protein abundance of the insulin-sensitive glucose transporter Glut4. Saponins 12-20 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 126-131 19781620-7 2009 Confocal microscopy confirmed that saponins/sapogenin treatment stimulated Akt phosphorylation and revealed that the treatment was followed by translocation of Glut4 into the cell membrane of C2C12 muscle cells. Saponins 35-43 thymoma viral proto-oncogene 1 Mus musculus 75-78 19781620-7 2009 Confocal microscopy confirmed that saponins/sapogenin treatment stimulated Akt phosphorylation and revealed that the treatment was followed by translocation of Glut4 into the cell membrane of C2C12 muscle cells. Saponins 35-43 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 160-165 19781620-8 2009 CONCLUSIONS: Saponins and sapogenin activate the PI3K/Akt pathway thus leading to phosphorylation and inactivation of GSK-3 alpha/beta with subsequent stimulation of glycogen synthesis as well as increase of Glut4-dependent glucose transport across the cell membrane. Saponins 13-21 thymoma viral proto-oncogene 1 Mus musculus 54-57 19781620-8 2009 CONCLUSIONS: Saponins and sapogenin activate the PI3K/Akt pathway thus leading to phosphorylation and inactivation of GSK-3 alpha/beta with subsequent stimulation of glycogen synthesis as well as increase of Glut4-dependent glucose transport across the cell membrane. Saponins 13-21 glycogen synthase kinase 3 alpha Mus musculus 118-129 19781620-8 2009 CONCLUSIONS: Saponins and sapogenin activate the PI3K/Akt pathway thus leading to phosphorylation and inactivation of GSK-3 alpha/beta with subsequent stimulation of glycogen synthesis as well as increase of Glut4-dependent glucose transport across the cell membrane. Saponins 13-21 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 208-213 19735711-0 2009 Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway. Saponins 6-14 CD34 molecule Homo sapiens 82-86 19735711-0 2009 Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway. Saponins 6-14 erythropoietin receptor Homo sapiens 98-102 19735711-0 2009 Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway. Saponins 6-14 Janus kinase 2 Homo sapiens 112-116 19735711-0 2009 Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway. Saponins 6-14 signal transducer and activator of transcription 5A Homo sapiens 117-122 19957887-2 2009 Saponin (SN1) isolated from C. infortunatum leaves in doses of 30, 50, 75 and 100 mg/kg, ip provided 36.28, 60.47, 90.71, 100% protection respectively from writhing induced by 1.2% v/v acetic acid. Saponins 0-7 solute carrier family 38, member 3 Mus musculus 9-12 19639231-1 2009 Ginsenoside Rp1, a semi-synthesized ginseng saponin, was shown to have chemopreventive action and anti-metastatic potential. Saponins 44-51 RP1 axonemal microtubule associated Homo sapiens 12-15 19426756-3 2009 Among saponins, timosaponin AIII (TA3) significantly reversed the scopolamine-induced deficits in a passive avoidance test and in the Morris water maze test. Saponins 6-14 RIKEN cDNA 2700049A03 gene Mus musculus 34-37 19505560-6 2009 CONCLUSIONS: Saponins are beneficial for improving hyperlipidemia and hyperglycemia by increasing the gene expression of adipsin, Glut4 and PPARgamma and reducing the gene expression of the enzyme G6Pase and FABP4 in C57BL/KsJ-db/db mice. Saponins 13-21 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 130-135 19505560-6 2009 CONCLUSIONS: Saponins are beneficial for improving hyperlipidemia and hyperglycemia by increasing the gene expression of adipsin, Glut4 and PPARgamma and reducing the gene expression of the enzyme G6Pase and FABP4 in C57BL/KsJ-db/db mice. Saponins 13-21 peroxisome proliferator activated receptor gamma Mus musculus 140-149 19505560-6 2009 CONCLUSIONS: Saponins are beneficial for improving hyperlipidemia and hyperglycemia by increasing the gene expression of adipsin, Glut4 and PPARgamma and reducing the gene expression of the enzyme G6Pase and FABP4 in C57BL/KsJ-db/db mice. Saponins 13-21 glucose-6-phosphatase, catalytic Mus musculus 197-203 19505560-6 2009 CONCLUSIONS: Saponins are beneficial for improving hyperlipidemia and hyperglycemia by increasing the gene expression of adipsin, Glut4 and PPARgamma and reducing the gene expression of the enzyme G6Pase and FABP4 in C57BL/KsJ-db/db mice. Saponins 13-21 fatty acid binding protein 4, adipocyte Mus musculus 208-213 19551732-0 2009 Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis). Saponins 34-42 pancreatic lipase Mus musculus 114-131 19551732-1 2009 The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of Chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. Saponins 54-61 pancreatic lipase Mus musculus 276-293 19627213-2 2009 SK1 is an edible saponin-rich compound from Platycodi radix. Saponins 17-24 skin antigen 1 Mus musculus 0-3 19634321-2 2009 Among the eleven saponins tested, four effectively inhibited beta-hexosaminidase release from rat peritoneal mast cells. Saponins 17-25 O-GlcNAcase Rattus norvegicus 61-80 19470246-0 2009 Effects of nanoparticulate saponin-platinum conjugates on 2,4-dinitrofluorobenzene-induced macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells. Saponins 27-34 chemokine (C-X-C motif) ligand 2 Mus musculus 91-124 19470246-5 2009 In addition, we found that nano saponin-Pt conjugates acted as a potent antioxidant that reduced the production of ROS and inhibited activation of the MAP kinase pathway and MIP-2 gene expression in response to DNFB. Saponins 32-39 chemokine (C-X-C motif) ligand 2 Mus musculus 174-179 19145554-1 2009 Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-cancer activities. Saponins 37-44 retinitis pigmentosa 1 (human) Mus musculus 12-15 19808358-4 2009 METHODS AND RESULTS: In patients with chronic heart failure treated with angiotensin-converting enzyme inhibition, cardiac oxidative capacity, measured in saponin-permeabilized fibers, was 25% lower, and proliferator-activated receptor-gamma coactivator-1alpha protein content was 34% lower compared with nonfailing controls. Saponins 155-162 angiotensin I converting enzyme Rattus norvegicus 73-102 19673391-0 2009 [Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse]. Saponins 29-37 synaptophysin Mus musculus 41-44 19678540-0 2009 The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. Saponins 70-78 interleukin 18 Homo sapiens 4-18 19678540-4 2009 Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Saponins 108-116 interleukin 18 Homo sapiens 80-85 19428913-2 2009 It has recently been shown that one member of an intracellular PRR, the NLRP3 inflammasome, is activated by a number of classical adjuvants including aluminum hydroxide and saponins [Eisenbarth SC, Colegio OR, O"Connor W, Sutterwala FS, Flavell RA. Saponins 173-181 NLR family, pyrin domain containing 3 Mus musculus 72-77 19145554-1 2009 Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-cancer activities. Saponins 37-44 retinitis pigmentosa 1 (human) Mus musculus 19-22 19445159-7 2009 Compared with model group, in total saponins of P. ginseng combined with berberine group can increase the contents of LVSP, +dp/dtmax, -dp/dtmax were increased, but were increased contents of LVEDP, plasma brain natriuretic peptide and Ca2+ concentration were decreased. Saponins 36-44 carbonic anhydrase 2 Rattus norvegicus 236-239 19624018-1 2009 OBJECTIVE: To explore the effect and the mechanism of panax notoginseng saponins (PNS) on the vascular intima hyperplasia and expression of proliferating cell nuclear antigen (PCNA) after aortic intima injury induced ballcon in rats. Saponins 72-80 proliferating cell nuclear antigen Rattus norvegicus 176-180 19148542-0 2009 Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Saponins 11-19 mitogen-activated protein kinase 1 Homo sapiens 44-47 19148542-0 2009 Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Saponins 11-19 nuclear factor kappa B subunit 1 Homo sapiens 60-69 19160368-4 2009 The saponin ginsenoside Rg1 (similar structure to astralagosides) was used as an internal standard. Saponins 4-11 protein phosphatase 1 regulatory subunit 3A Homo sapiens 24-27 19504380-3 2009 The effects of two major saponins (clematichinenosides AR and AR(2)) on the secretion of TNF-alpha in murine peritoneal macrophages induced by lipopolysaccharides were further investigated. Saponins 25-33 tumor necrosis factor Mus musculus 89-98 19059471-0 2009 Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. Saponins 6-14 caspase 1 Rattus norvegicus 63-71 19336893-3 2009 In our previous report, we demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active ingredients of ginseng saponins, inhibits human Kv1.4 (hKv1.4) channel currents through the interaction with amino acids, including Lys (K) residue, which is known as K(+) activation and the extracellular tetraethylammonium (TEA) binding site. Saponins 119-127 potassium voltage-gated channel subfamily A member 4 Homo sapiens 144-149 19336893-3 2009 In our previous report, we demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active ingredients of ginseng saponins, inhibits human Kv1.4 (hKv1.4) channel currents through the interaction with amino acids, including Lys (K) residue, which is known as K(+) activation and the extracellular tetraethylammonium (TEA) binding site. Saponins 119-127 potassium voltage-gated channel subfamily A member 4 Homo sapiens 151-157 19655412-0 2009 Total saponins of Panax ginseng induces K562 cell differentiation by promoting internalization of the erythropoietin receptor. Saponins 6-14 erythropoietin receptor Homo sapiens 102-125 19938225-1 2009 This study was carried out to determine the effect of saponins of Panax notoginseng (SPN), a naturally occurring cardiovascular agent, on: (1) glucose uptake, (2) GLUT4 translocation and (3) glycogen synthesis in 3T3-L1 adipocytes. Saponins 54-62 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 163-168 19363238-0 2009 Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins. Saponins 86-94 apolipoprotein E Mus musculus 49-53 19363238-1 2009 The aim of this study was to test the effects of Ilex kudingcha total saponins on hemorheology of ApoE-/- mice suffering from hypercholesterolemia induced by high-cholesterol diet. Saponins 70-78 apolipoprotein E Mus musculus 98-102 18499341-0 2008 Saponins derived from the roots of Platycodon grandiflorum inhibit HT-1080 cell invasion and MMPs activities: regulation of NF-kappaB activation via ROS signal pathway. Saponins 0-8 matrix metallopeptidase 2 Homo sapiens 93-97 18955103-1 2008 This study examined the apoptotic effects of crude saponins acquired from the roots of Platycodon grandiflorum (SPR) in HT-29 human colon cancer cells. Saponins 51-59 sepiapterin reductase Homo sapiens 112-115 18495126-10 2008 ELISA of sera revealed IgG1 to be elevated in recNcROP2-saponin vaccinated mice, whilst IgG2a was higher in recNcROP2-FIA vaccinated animals. Saponins 56-63 LOC105243590 Mus musculus 23-27 19317166-0 2008 [Effects of panax notoginseng saponins on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells injury induced by oxidized low-density lipoprotein]. Saponins 30-38 intercellular adhesion molecule 1 Homo sapiens 56-89 18758081-1 2008 Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin with a chemopreventive action. Saponins 43-50 RP1 axonemal microtubule associated Homo sapiens 12-15 18758081-1 2008 Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin with a chemopreventive action. Saponins 43-50 RP1 axonemal microtubule associated Homo sapiens 19-22 18816528-5 2008 To our knowledge, this is the first study to demonstrate that steroidal saponins stimulate rat growth-hormone release in rat pituitary cells. Saponins 72-80 gonadotropin releasing hormone receptor Rattus norvegicus 95-109 18786325-10 2008 In the in vitro experiment, it was shown that rhizoma paridis total saponins in concentrations of 5, 10, 20 and 40 mg/L could inhibit remarkably the release of TNF-alpha and IL-1 beta from LPS-stimulated PMPhi of rats (all P < 0.01). Saponins 68-76 tumor necrosis factor Rattus norvegicus 160-169 18830889-4 2008 In the studies reported here, we noted that with these cells, these RIP solutions only became highly cytotoxic when they were used in a combined treatment with Gypsophila saponins. Saponins 171-179 receptor interacting serine/threonine kinase 1 Homo sapiens 68-71 19105274-1 2008 OBJECTIVE: To investigate the effect of rhizoma paridis total saponins(RPTS)on the levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in blood serum of two-hit rat model induced by multiple fractures and lipopolysaccharide. Saponins 62-70 tumor necrosis factor Rattus norvegicus 93-120 18502060-2 2008 Ginsenosides Rg1 and Rb1 were extracted from Panax notoginseng saponins (PNS). Saponins 63-71 RB transcriptional corepressor 1 Rattus norvegicus 21-24 18718060-0 2008 [Effect of total saponins of Panaxginseng on bax and bcl-xl gene expression in HL-60 cells]. Saponins 17-25 BCL2 associated X, apoptosis regulator Homo sapiens 45-48 18718060-0 2008 [Effect of total saponins of Panaxginseng on bax and bcl-xl gene expression in HL-60 cells]. Saponins 17-25 BCL2 like 1 Homo sapiens 53-59 18718060-1 2008 The aim of this study was to investigate the effect of the total saponins of Panaxginseng (TSPG) on cells expression of apoptosis-related genes bax and bcl-xl in HL-60 cells and its mechanism inducing apoptosis of HL-60 cells. Saponins 65-73 BCL2 associated X, apoptosis regulator Homo sapiens 144-147 18718060-1 2008 The aim of this study was to investigate the effect of the total saponins of Panaxginseng (TSPG) on cells expression of apoptosis-related genes bax and bcl-xl in HL-60 cells and its mechanism inducing apoptosis of HL-60 cells. Saponins 65-73 BCL2 like 1 Homo sapiens 152-158 18786325-10 2008 In the in vitro experiment, it was shown that rhizoma paridis total saponins in concentrations of 5, 10, 20 and 40 mg/L could inhibit remarkably the release of TNF-alpha and IL-1 beta from LPS-stimulated PMPhi of rats (all P < 0.01). Saponins 68-76 interleukin 1 beta Rattus norvegicus 174-183 18501482-11 2008 These results suggested that the number of sugar residues in the glycidic chains attached to C-3 of aglycone could affect the haemolytic and adjuvant activities of platycodigenin-type saponins, and that PD had immunological adjuvant activity, and simultaneously elicited a Th1 and Th2 immune response by regulating gene expression of Th1/Th2 cytokines and transcription factors. Saponins 184-192 complement component 3 Mus musculus 93-96 18837333-1 2008 Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. Saponins 60-68 RB transcriptional corepressor 1 Homo sapiens 12-15 18547688-0 2008 A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum. Saponins 67-75 negative elongation factor complex member C/D, Th1l Mus musculus 21-24 18547688-0 2008 A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum. Saponins 67-75 heart and neural crest derivatives expressed 2 Mus musculus 29-32 18086515-0 2008 Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Saponins 8-15 matrix metalloproteinase MMP2 Glycine max 76-81 18086515-1 2008 The antimetastatic properties of soybean saponin were investigated by evaluating matrix metalloproteinase (MMP-2 and MMP-9) production in HT-1080 cells. Saponins 41-48 matrix metalloproteinase MMP2 Glycine max 107-112 18086515-5 2008 The treatment of HT-1080 cells with soybean saponin inhibited the mRNA expression of and reduced the amounts of secreted MMP-2 and MMP-9, whereas it increased the amount of secreted TIMP-2 dose-dependently. Saponins 44-51 matrix metalloproteinase MMP2 Glycine max 121-126 18086515-9 2008 Our current data support the notion that soybean saponin inhibits tumor cell metastasis by suppressing MMP-2 and MMP-9 productions, and stimulating TIMP-2 secretion, thereby suggesting that soybean saponin has a chemopreventive property against cancer metastasis. Saponins 49-56 matrix metalloproteinase MMP2 Glycine max 103-108 18288389-0 2008 A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Saponins 10-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 103-124 18061674-8 2008 Treatment with either streptolysin-O or saponin, lipid rafts disrupting agents, abolishes the ethanol-induced activation of the TLR4/IL-1RI signaling pathway. Saponins 40-47 toll-like receptor 4 Mus musculus 128-132 17948236-7 2008 The highest levels of ZAP-70 fluorescence occurred when cells were permeabilized using a noncommercial saponin procedure. Saponins 103-110 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 22-28 18243933-5 2008 In contrast, labelling of CD79alpha and IFN-gamma was possible with all investigated fixation/permeabilisation variants; however, here saponin and Tween protocols induced a higher degree of unspecific binding. Saponins 135-142 CD79a molecule Sus scrofa 26-35 18300467-0 2007 [Effects of Panax notoginseng saponins on long-term potentiation in the CA1 region of the rat hippocampus]. Saponins 30-38 carbonic anhydrase 1 Rattus norvegicus 72-75 18214757-1 2008 PURPOSE: This article was intended to improve the absorption of ginsenoside Rg1 and Rb1 of Panax notoginseng saponins (PNS). Saponins 109-117 RB transcriptional corepressor 1 Rattus norvegicus 84-87 18006124-5 2007 In CD80 or CD86 KO mice, formulations with the saponin derivative, QS21 could efficiently default to the other B7 molecule. Saponins 47-54 CD80 antigen Mus musculus 3-7 18006124-5 2007 In CD80 or CD86 KO mice, formulations with the saponin derivative, QS21 could efficiently default to the other B7 molecule. Saponins 47-54 CD86 antigen Mus musculus 11-15 17786021-6 2007 Saponin also induced GFP-LC3 puncta in Atg5(-/-) MEF transfected with GFP-LC3, where no LC3-II is produced, demonstrating that the puncta are autophagosome-independent. Saponins 0-7 E74 like ETS transcription factor 4 Homo sapiens 49-52 18198636-0 2007 [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]. Saponins 31-38 insulin Homo sapiens 42-49 18198636-1 2007 OBJECTIVE: To investigate the effect of panax quinquefolius saponin(PQS) on blood glucose, blood lipid and insulin sensitivity in patients of coronary heart disease (CHD) with blood glucose abnormality (BGA). Saponins 60-67 insulin Homo sapiens 107-114 17148504-4 2007 Our findings have shown that Astragalus saponins (AST) inhibit cell proliferation through accumulation in S phase and G2/M arrest, with concomitant suppression of p21 expression and inhibition of cyclin-dependent kinase activity. Saponins 40-48 H3 histone pseudogene 16 Homo sapiens 163-166 17786275-10 2007 Indeed, pretreatment with a p38 inhibitor decreased saponin-induced apoptosis with a significant decrease in DNA fragmentation. Saponins 52-59 mitogen-activated protein kinase 14 Homo sapiens 28-31 17708802-0 2007 [Effects of Ginseng panaxadiol saponin on proliferation and differentiation of human bone marrow CD34+ cells]. Saponins 31-38 CD34 molecule Homo sapiens 97-101 17708802-1 2007 The study was purposed to investigate the effects of the panaxadiol saponin (PDS) from Ginseng on proliferation and differentiation of human CD34(+) cells from human bone marrow. Saponins 68-75 CD34 molecule Homo sapiens 141-145 17461933-6 2007 RESULTS: Western blot analysis of immunoprecipitates showed that introduction of the inhibitory peptide decreased tyrosine phosphorylation of PMCA by nearly 60% in saponin-permeabilized, thrombin-treated platelets as compared with the scrambled control peptide. Saponins 164-171 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 142-146 17461933-6 2007 RESULTS: Western blot analysis of immunoprecipitates showed that introduction of the inhibitory peptide decreased tyrosine phosphorylation of PMCA by nearly 60% in saponin-permeabilized, thrombin-treated platelets as compared with the scrambled control peptide. Saponins 164-171 coagulation factor II, thrombin Homo sapiens 187-195 17428004-4 2007 36 major chromatographic peaks of FDP, including 14 saponins, 13 phenolic acids and nine diterpenoid quinones were characterized by their MS spectra and in comparison with some of the reference standards. Saponins 52-60 fructose-bisphosphatase 1 Rattus norvegicus 34-37 19086568-0 2007 Isolation of saponin from dried roots of Gypsophila simonii Hub. Saponins 13-20 ELAV like RNA binding protein 2 Homo sapiens 60-63 17461933-4 2007 METHODS: A decapeptide including the tyrosine phosphorylation site of PMCA and a scrambled version were synthesized and introduced into human platelets using saponin. Saponins 158-165 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 70-74 17454255-2 2007 The purpose of this study was to determine the effect of ginseng saponin mRg2, a mixture of ginsenosides containing 60% Rg2, on the repair and apoptosis of ultraviolet B (UVB)-exposed NIH3T3 cells. Saponins 65-72 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Mus musculus 73-77 16924497-2 2007 The present study was designed to determine biological structure-activity relationships (SAR) for saponins present in Panax ginseng fruits. Saponins 98-106 sarcosine dehydrogenase Homo sapiens 89-92 17526173-0 2007 [Effect of panax quinquefolius saponin on angiogenesis and expressions of VEGF and bFGF in myocardium of rats with acute myocardial infarction]. Saponins 31-38 vascular endothelial growth factor A Rattus norvegicus 74-78 17526173-1 2007 OBJECTIVE: To study the effect of Panax quinquefolius Saponin (PQS), an extraction from stem and leaf of American ginseng, on vascular regeneration in infarcted area, and expressions of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in myocardium of rats with acute myocardial infarction (AMI). Saponins 54-61 vascular endothelial growth factor A Rattus norvegicus 222-226 17526173-1 2007 OBJECTIVE: To study the effect of Panax quinquefolius Saponin (PQS), an extraction from stem and leaf of American ginseng, on vascular regeneration in infarcted area, and expressions of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in myocardium of rats with acute myocardial infarction (AMI). Saponins 54-61 fibroblast growth factor 2 Rattus norvegicus 264-268 17454307-3 2007 The saponin produced a beneficial effect on resuscitation of haemorrhagic shock as follows: first, it could significantly rise increased mean arterial pressure; second, it could increased blood oxygen content; third, it could markedly decreased serum lipoperoxidase and increased superoxide dismutase (SOD) activities. Saponins 4-11 superoxide dismutase 1 Homo sapiens 280-300 17454307-3 2007 The saponin produced a beneficial effect on resuscitation of haemorrhagic shock as follows: first, it could significantly rise increased mean arterial pressure; second, it could increased blood oxygen content; third, it could markedly decreased serum lipoperoxidase and increased superoxide dismutase (SOD) activities. Saponins 4-11 superoxide dismutase 1 Homo sapiens 302-305 17409572-0 2007 An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii. Saponins 21-28 cytochrome c oxidase II, mitochondrial Mus musculus 60-65 17393022-3 2007 Activation of saponin-permeabilized platelets in the presence of a peptide composed of the last ten residues of the PMCA4b C-terminus leads to a significant decrease of PMCA associated with the cytoskeleton, suggesting that PDZ domain interactions play a role in tethering the pump to the cytoskeleton. Saponins 14-21 ATPase plasma membrane Ca2+ transporting 4 Homo sapiens 116-122 17393022-3 2007 Activation of saponin-permeabilized platelets in the presence of a peptide composed of the last ten residues of the PMCA4b C-terminus leads to a significant decrease of PMCA associated with the cytoskeleton, suggesting that PDZ domain interactions play a role in tethering the pump to the cytoskeleton. Saponins 14-21 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 116-120 17454255-2 2007 The purpose of this study was to determine the effect of ginseng saponin mRg2, a mixture of ginsenosides containing 60% Rg2, on the repair and apoptosis of ultraviolet B (UVB)-exposed NIH3T3 cells. Saponins 65-72 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Mus musculus 74-77 17268065-3 2007 In this study, we examined the effect of macrostemonoside A, a tigogenin steroidal saponin isolated from the bulbs of Allium macrostemon Bung on the expression of visfatin in differentiated 3T3-L1 adipocytes. Saponins 83-90 nicotinamide phosphoribosyltransferase Mus musculus 163-171 17268104-5 2007 Among the new saponins, foliatheasaponins II and III, were found to inhibit release of beta-hexosaminidase, as a marker of antigen-induced degranulation, in RBL-2H3 cells. Saponins 14-22 O-GlcNAcase Rattus norvegicus 87-106 17092489-0 2007 Acylation with diangeloyl groups at C21-22 positions in triterpenoid saponins is essential for cytotoxicity towards tumor cells. Saponins 69-77 TBL1X/Y related 1 Homo sapiens 36-39 17092489-5 2007 This saponin is a triterpenoid saponin with a trisaccharide chain attached at C3 of the aglycone and two angeloyl groups acylated at C21 and C22. Saponins 5-12 transducin (beta)-like 1X-linked receptor 1 Mus musculus 133-136 17092489-5 2007 This saponin is a triterpenoid saponin with a trisaccharide chain attached at C3 of the aglycone and two angeloyl groups acylated at C21 and C22. Saponins 5-12 Sp7 transcription factor 7 Mus musculus 141-144 17092489-5 2007 This saponin is a triterpenoid saponin with a trisaccharide chain attached at C3 of the aglycone and two angeloyl groups acylated at C21 and C22. Saponins 31-38 transducin (beta)-like 1X-linked receptor 1 Mus musculus 133-136 17092489-5 2007 This saponin is a triterpenoid saponin with a trisaccharide chain attached at C3 of the aglycone and two angeloyl groups acylated at C21 and C22. Saponins 31-38 Sp7 transcription factor 7 Mus musculus 141-144 17069940-7 2007 Of the ginsenosides studied, Rg1, Re, Rg2, Rg3 and Rb1 have more potent adjuvant properties than the others, indicating that they are the major constituents contributing to the adjuvant activities of total ginseng saponins. Saponins 214-222 protein phosphatase 1, regulatory subunit 3A Mus musculus 29-32 17343007-1 2007 OBJECTIVE: To observe the effect of Panax notoginseng saponins (PNS) on serum content of neuronal specific enolase (NSE) and function recovery in patients with cerebral hemorrhage (CH) for exploring the therapeutic action of PNS in treating CH. Saponins 54-62 enolase 2 Homo sapiens 116-119 17069940-7 2007 Of the ginsenosides studied, Rg1, Re, Rg2, Rg3 and Rb1 have more potent adjuvant properties than the others, indicating that they are the major constituents contributing to the adjuvant activities of total ginseng saponins. Saponins 214-222 RB transcriptional corepressor 1 Mus musculus 51-54 17159501-3 2007 In this study, a new triterpenoid saponin (GC-1) was extracted from the fruit of Gymnocladus chinensis Baillon and its biological actions were investigated. Saponins 34-41 olfactomedin 4 Homo sapiens 43-47 17193304-3 2006 These two saponins were evaluated for haemolytic activities and adjuvant potentials on the cellular and humoral immune responses of ICR mice against ovalbumin (OVA). Saponins 10-18 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 149-158 16982463-6 2006 The saponins fraction displayed the best antiproliferative effect on the PC3 cell line with 18 microg/ml as GI50. Saponins 4-12 chromobox 8 Homo sapiens 73-76 17076642-0 2006 Isolation, characterization and study of enhancing effects on nasal absorption of insulin in rat of the total saponin from Acanthophyllum squarrosum. Saponins 110-117 insulin Homo sapiens 82-89 16581872-7 2006 Adenosine (1-100 nm) and the specific A2A receptor agonist CGS 21680 (1-50 nm) produced a concentration-dependant potentiation of the caffeine-induced Ca2+ release from saponin-skinned fibres. Saponins 169-176 carbonic anhydrase 2 Mustela putorius furo 151-154 16557452-1 2006 This research attempts to clarify the cause for poor oral absorption of ginsenoside Rb1 (Rb1), one main ingredient of the well known Panax notoginseng saponins (PNS) for curing hemorrhage. Saponins 151-159 RB transcriptional corepressor 1 Homo sapiens 84-87 16637684-0 2006 Quillaja saponin can modulate ovalbumin-induced IgE allergic responses through regulation of Th1/Th2 balance in a murine model. Saponins 9-16 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 30-39 16637684-0 2006 Quillaja saponin can modulate ovalbumin-induced IgE allergic responses through regulation of Th1/Th2 balance in a murine model. Saponins 9-16 negative elongation factor complex member C/D, Th1l Mus musculus 93-96 16637684-0 2006 Quillaja saponin can modulate ovalbumin-induced IgE allergic responses through regulation of Th1/Th2 balance in a murine model. Saponins 9-16 heart and neural crest derivatives expressed 2 Mus musculus 97-100 16637684-3 2006 The purpose of this study is to investigate whether Quillaja saponin can suppress ovalbumin (OVA)-induced IgE-mediated allergic responses through promoting a dominant Th1 immune response. Saponins 61-68 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 82-91 16637684-3 2006 The purpose of this study is to investigate whether Quillaja saponin can suppress ovalbumin (OVA)-induced IgE-mediated allergic responses through promoting a dominant Th1 immune response. Saponins 61-68 negative elongation factor complex member C/D, Th1l Mus musculus 167-170 16637684-13 2006 Suppression of OVA-specific IgG1 and an increase of OVA-IgG2a were observed in mice fed saponin. Saponins 88-95 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 28-32 16637684-13 2006 Suppression of OVA-specific IgG1 and an increase of OVA-IgG2a were observed in mice fed saponin. Saponins 88-95 immunoglobulin heavy variable V1-9 Mus musculus 56-61 20085228-3 2006 The results of in vitro cytotoxic activity of the mixture of spirostanol saponins against cell lines melanoma B16 and sarcoma XC and human fibroblasts HSF are also reported. Saponins 73-81 interleukin 6 Homo sapiens 151-154 16519972-0 2006 Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice. Saponins 41-49 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 96-105 16539852-1 2006 AIM: To clarify the cause of poor oral absorption of ginsenoside Rg1 (Rg1), the active ingredient in Panax notoginseng saponins (PNS) used for treating hemorrhage. Saponins 119-127 protein phosphatase 1 regulatory subunit 3A Homo sapiens 65-68 16539852-1 2006 AIM: To clarify the cause of poor oral absorption of ginsenoside Rg1 (Rg1), the active ingredient in Panax notoginseng saponins (PNS) used for treating hemorrhage. Saponins 119-127 protein phosphatase 1 regulatory subunit 3A Homo sapiens 70-73 16760614-1 2006 Three saponins were extracted and isolated from starfish by reversed-phase high performance liquid chromatography (HPLC), and analyzed by fast atom bombardment mass spectrometry (FAB-MS). Saponins 6-14 FA complementation group B Homo sapiens 179-182 16557452-1 2006 This research attempts to clarify the cause for poor oral absorption of ginsenoside Rb1 (Rb1), one main ingredient of the well known Panax notoginseng saponins (PNS) for curing hemorrhage. Saponins 151-159 RB transcriptional corepressor 1 Homo sapiens 89-92 16271738-0 2006 Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum. Saponins 117-125 tumor necrosis factor Homo sapiens 14-41 16332509-2 2006 These saponins were evaluated for their haemolytic activities and adjuvant potentials on the cellular and humoral immune responses of ICR mice against ovalbumin (OVA). Saponins 6-14 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 151-160 16711421-0 2006 [Determination of 20 (S)-ginsengnoside Rh2 in the alkali-hydrolysis product of saponins from leaves of Panax qinquefolium by RP-HPLC]. Saponins 79-87 Rh associated glycoprotein Homo sapiens 39-42 16711421-1 2006 OBJECTIVE: To determine 20(S)-ginsengnoside Rh2 in the hydrolysis product of saponins from leaves of Panax qinquefolium. Saponins 77-85 Rh associated glycoprotein Homo sapiens 44-47 16214270-0 2006 Haemolytic activities and adjuvant effect of Bupleurum chinense saponins on the immune responses to ovalbumin in mice. Saponins 64-72 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 100-109 16214270-1 2006 In this study, the haemolytic activities of Bupleurum chinense saponins (BCS) and its adjuvant potentials on the immune responses of ICR mice against ovalbumin (OVA) were evaluated. Saponins 63-71 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 150-159 16411770-7 2006 Confocal microscopy confirmed membrane localization of epitope-tagged hASBT in saponin-treated (permeabilized) and nonpermeabilized transfected COS-1 and MDCK cells. Saponins 79-86 solute carrier family 10 member 2 Homo sapiens 70-75 16417288-0 2006 Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. Saponins 12-20 pancreatic lipase Mus musculus 96-113 16297897-0 2006 Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety. Saponins 64-72 replication factor C subunit 1 Homo sapiens 47-49 16049964-0 2006 Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Saponins 8-15 matrix metallopeptidase 9 Homo sapiens 60-86 16049964-0 2006 Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Saponins 8-15 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 120-139 16049964-3 2006 We investigated the effects of a ginseng saponin metabolite, compound K (20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol), on MMP-9 expression in human astroglioma cells. Saponins 41-48 matrix metallopeptidase 9 Homo sapiens 129-134 16297708-5 2005 Soybean saponins also down-regulated the expression of COX-2 and iNOS at mRNA/protein levels. Saponins 8-16 cox2 Glycine max 55-60 16183855-0 2005 Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2. Saponins 37-44 caspase 8 Homo sapiens 72-81 16183855-0 2005 Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2. Saponins 37-44 BCL2 apoptosis regulator Homo sapiens 104-109 16198226-4 2005 Septic insult by lipopolysaccharide and interferon-gamma increased ascorbate recycling in astrocytes permeabilized with saponin but decreased it in those with intact plasma membrane. Saponins 120-127 interferon gamma Rattus norvegicus 40-56 16043270-0 2005 Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Saponins 69-77 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 111-120 16141537-0 2005 Isolation of saponins with the inhibitory effect on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production from Pleurospermum kamtschaticum. Saponins 13-21 ATPase, H+ transporting, lysosomal V1 subunit E1 Mus musculus 80-114 16261522-0 2005 Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice. Saponins 69-77 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 105-114 15935506-3 2005 Here we investigated whether saponins are able to enhance the efficacy of a receptor-specific chimeric toxin consisting of saporin-3, epidermal growth factor and a molecular adapter previously shown to reduce side effects on non-target cells. Saponins 29-37 epidermal growth factor Mus musculus 134-157 16080910-5 2005 Subcellular localization of ERbeta isoforms was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques and affinity purified polyclonal antibodies specific for ERbeta-1 as well as to two of the truncated carboxy terminus isoforms (beta-2 and beta-5). Saponins 82-89 estrogen receptor 2 Homo sapiens 28-34 15996266-0 2005 Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI. Saponins 11-18 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 62-68 16320219-1 2005 Saponins with an aldehyde function bound at C-4 from different plant origins increase the cytotoxicity of the lectin agrostin by enhancing its penetration through the cell membrane. Saponins 0-8 complement C4A (Rodgers blood group) Homo sapiens 44-47 15996266-0 2005 Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI. Saponins 11-18 CD63 molecule Homo sapiens 73-77 15996266-0 2005 Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI. Saponins 11-18 Fc epsilon receptor Ia Homo sapiens 163-174 15996266-3 2005 In a recent report, detection of CD203c after lysis with Saponin was shown to be superior to detection of CD63 after lysis with formic acid. Saponins 57-64 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 33-39 15996266-9 2005 RESULTS: More basophils (median 1164 vs. median 397) and better discrimination of upregulated CD203c and CD63 amongst responders were obtained after lysis with Saponin than after lysis with formic acid. Saponins 160-167 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 94-100 15996266-9 2005 RESULTS: More basophils (median 1164 vs. median 397) and better discrimination of upregulated CD203c and CD63 amongst responders were obtained after lysis with Saponin than after lysis with formic acid. Saponins 160-167 CD63 molecule Homo sapiens 105-109 16124609-0 2005 [Effects of the Panax notoginseng saponins on the level of synaptophysin protein in brain in rat model with lesion of Meynert]. Saponins 34-42 synaptophysin Rattus norvegicus 59-72 15739095-1 2005 Ginsenoside Rh2 (Rh2), a purified ginseng saponin, has been shown to have antiproliferative effects in certain cancer cell types. Saponins 42-49 Rh associated glycoprotein Homo sapiens 12-15 15739095-1 2005 Ginsenoside Rh2 (Rh2), a purified ginseng saponin, has been shown to have antiproliferative effects in certain cancer cell types. Saponins 42-49 Rh associated glycoprotein Homo sapiens 17-20 16075720-1 2005 OBJECTIVE: To study the protective effects of Panax notoginseng saponins (PNS) on angiotensin II (Ang II)-induced rat cardiomyocyte apoptosis in vitro and the probable mechanism. Saponins 64-72 angiotensinogen Rattus norvegicus 98-104 15842772-0 2005 Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes. Saponins 29-37 potassium voltage-gated channel subfamily H member 2 Homo sapiens 66-70 15842772-1 2005 AIM: To examine the effects of ginseng saponins on the heterologously expressed human ether-a-go-go related gene (HERG) that encodes the rapid component of the delayed rectifier K+ channel. Saponins 39-47 potassium voltage-gated channel subfamily H member 2 Homo sapiens 114-118 15842772-4 2005 RESULTS: Crude saponins of Korean red ginseng (GS) induced a minimal increase of the maximal HERG conductance without changes in the voltage-dependent HERG current activation and inactivation curves. Saponins 15-23 potassium voltage-gated channel subfamily H member 2 Homo sapiens 93-97 15842772-6 2005 Consistently, ginseng saponins increased the HERG deactivation time constants with the order of potency of Rg1 (a major component of PT)>Rf1>Rb1 (a major component of PD). Saponins 22-30 potassium voltage-gated channel subfamily H member 2 Homo sapiens 45-49 15842772-9 2005 CONCLUSION: Ginseng saponins enhance HERG currents, which could be in part a possible mechanism of the shortening cardiac action potential of ginseng saponins. Saponins 20-28 potassium voltage-gated channel subfamily H member 2 Homo sapiens 37-41 15842772-9 2005 CONCLUSION: Ginseng saponins enhance HERG currents, which could be in part a possible mechanism of the shortening cardiac action potential of ginseng saponins. Saponins 150-158 potassium voltage-gated channel subfamily H member 2 Homo sapiens 37-41 15748625-0 2005 Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Saponins 95-103 nitric oxide synthase 2, inducible Mus musculus 14-45 15748625-3 2005 In this study, we investigated the effects of seven platycodin saponins on the activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Saponins 63-71 nitric oxide synthase 2, inducible Mus musculus 93-124 15748625-3 2005 In this study, we investigated the effects of seven platycodin saponins on the activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Saponins 63-71 nitric oxide synthase 2, inducible Mus musculus 126-130 15748625-3 2005 In this study, we investigated the effects of seven platycodin saponins on the activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Saponins 63-71 cytochrome c oxidase II, mitochondrial Mus musculus 155-160 15748625-10 2005 These results suggest that the main inhibitory mechanism of the platycodin saponins may be the reduction of iNOS and COX-2 gene expression through blocking of NF-kappaB activation. Saponins 75-83 nitric oxide synthase 2, inducible Mus musculus 108-112 15748625-10 2005 These results suggest that the main inhibitory mechanism of the platycodin saponins may be the reduction of iNOS and COX-2 gene expression through blocking of NF-kappaB activation. Saponins 75-83 cytochrome c oxidase II, mitochondrial Mus musculus 117-122 15789748-0 2005 In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase. Saponins 45-53 pancreatic lipase Homo sapiens 78-95 16131033-0 2005 [Effect of Panax notoginseng saponins on intercellular adhesion molecule-1 expression and neutrophil infiltration in cerebral infarction tissue of rats]. Saponins 29-37 intercellular adhesion molecule 1 Rattus norvegicus 41-74 16131033-1 2005 OBJECTIVE: To investigate the effect of Panax notoginseng saponins (Pns) on the expression of intercellular adhesion molecule-1 (ICAM-1) and brain neutrophil infiltration induced by transient focal cerberal ischemia and reperfusion in rats. Saponins 58-66 intercellular adhesion molecule 1 Rattus norvegicus 94-127 16131033-1 2005 OBJECTIVE: To investigate the effect of Panax notoginseng saponins (Pns) on the expression of intercellular adhesion molecule-1 (ICAM-1) and brain neutrophil infiltration induced by transient focal cerberal ischemia and reperfusion in rats. Saponins 58-66 intercellular adhesion molecule 1 Rattus norvegicus 129-135 15789748-3 2005 The total saponin fraction of Platycodi Radix appeared to have a potent inhibitory activity against the hydrolysis of triolein emulsified with phosphatidycholine by pancreatic lipase in vitro. Saponins 10-17 pancreatic lipase Homo sapiens 165-182 15789748-4 2005 Based on these results, further purification of active components yielded 10 known triterpenoidal saponins, among these compounds, platycodin A, C, D, and deapioplatycodin D exhibited significant inhibitory effects on PL at the concentration of 500 microg/mL with 3.3, 5.2, 34.8, and 11.67% pancreatic lipase activity vs control, respectively. Saponins 98-106 pancreatic lipase Homo sapiens 218-220 15789748-6 2005 Therefore, the anti-obesity effect of Platycodi Radix might be due to the inhibition of pancreatic lipase by its saponins. Saponins 113-121 pancreatic lipase Homo sapiens 88-105 15471899-6 2005 of saponins also resulted in a transient accumulation of cells in the S-phase of the cell cycle that was associated with a significant reduction of cyclin-dependant kinase-2 (CDK-2) activity. Saponins 3-11 cyclin dependent kinase 2 Homo sapiens 148-173 15471899-6 2005 of saponins also resulted in a transient accumulation of cells in the S-phase of the cell cycle that was associated with a significant reduction of cyclin-dependant kinase-2 (CDK-2) activity. Saponins 3-11 cyclin dependent kinase 2 Homo sapiens 175-180 15485778-0 2004 [Effect of total Panax notoginseng saponins on the activity of human endothelial nitric oxide synthase gene promoter]. Saponins 35-43 nitric oxide synthase 3 Homo sapiens 69-102 15583046-12 2005 On d 20, IgG and CRP were greater (P < 0.05) in saponin-supplemented pigs (IgG = 17.5 vs. 11.4 mg/mL; CRP = 26.98 vs. 12.5 mg/mL). Saponins 51-58 C-reactive protein Sus scrofa 105-108 15485778-1 2004 OBJECTIVE: To study the mechanism of total Panax notoginseng saponin (tPNS) in regulating the transcription activity of human endothelial nitric oxide synthase (heNOS) gene promoter. Saponins 61-68 nitric oxide synthase 3 Homo sapiens 126-159 15172114-0 2004 Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. Saponins 28-35 NFKB inhibitor alpha Homo sapiens 72-84 15478202-0 2004 Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. Saponins 24-32 endothelin receptor type A Homo sapiens 110-113 15478202-0 2004 Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. Saponins 24-32 angiotensin II receptor type 1 Homo sapiens 130-133 15478202-1 2004 Different types of triterpenes including saponins and aglycons were evaluated for their ability to inhibit [3H] BQ-123 and [3H] angiotensin II binding to the human endothelin 1 ETA and angiotensin II AT1 receptors, respectively. Saponins 41-49 angiotensinogen Homo sapiens 128-142 15364435-0 2004 Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice. Saponins 37-45 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 73-82 15364435-1 2004 In this study, the haemolytic activities of Panax notoginseng saponins (PNS) and its adjuvant potentials on the cellular and humoral immune responses of ICR mice against ovalbumin (OVA) were evaluated. Saponins 62-70 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 170-179 15478202-2 2004 Selectivity for only one of the two receptors was exhibited by asiatic acid and its saponins (ETA) and oleanolic acid (AT1). Saponins 84-92 endothelin receptor type A Homo sapiens 94-97 15478202-5 2004 Highly haemolytic saponins such as alpha-hederin and beta-escine showed partial (60%) inhibition of radioligand-binding to the ETA receptor and complete inhibition (100%) to the AT1 receptor. Saponins 18-26 endothelin receptor type A Homo sapiens 127-130 15478202-5 2004 Highly haemolytic saponins such as alpha-hederin and beta-escine showed partial (60%) inhibition of radioligand-binding to the ETA receptor and complete inhibition (100%) to the AT1 receptor. Saponins 18-26 angiotensin II receptor type 1 Homo sapiens 178-181 15172114-0 2004 Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. Saponins 28-35 proline rich transmembrane protein 2 Homo sapiens 86-102 15172114-0 2004 Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. Saponins 28-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 108-124 15172114-5 2004 Crude soy saponin extract suppressed the degradation of IkappaBalpha in PMA-stimulated cells, while COX-2 and PKC expressions were significantly down-regulated. Saponins 10-17 NFKB inhibitor alpha Homo sapiens 56-68 15172114-5 2004 Crude soy saponin extract suppressed the degradation of IkappaBalpha in PMA-stimulated cells, while COX-2 and PKC expressions were significantly down-regulated. Saponins 10-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 100-105 15172114-5 2004 Crude soy saponin extract suppressed the degradation of IkappaBalpha in PMA-stimulated cells, while COX-2 and PKC expressions were significantly down-regulated. Saponins 10-17 proline rich transmembrane protein 2 Homo sapiens 110-113 15010693-2 2004 Since ppd-type saponins are known to be completely metabolized to 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1) by intestinal bacteria when taken orally, M1 and ginsenoside Rb1, as a representative of ppd-type saponins, were examined for cognitive disorder. Saponins 15-23 RB transcriptional corepressor 1 Mus musculus 181-184 15248179-6 2004 To confirm that anti-CD19 mAb (clone SJ25-C1)-treated PMNs definitely produce TNF alpha, we measured the levels of intracellular expression of TNF alpha in PMNs permeabilized by saponin. Saponins 178-185 tumor necrosis factor Mus musculus 143-152 15165836-3 2004 [35S]GTPgammaS binding assays in saponin-permeabilized CGCs showed that G-protein activation by the CB1 agonist, WIN55212-2, and adenosine A1 agonist, phenylisopropyladenosine, was maximal during the second week in culture. Saponins 33-40 cannabinoid receptor 1 Rattus norvegicus 100-103 14660672-4 2004 The altered organization of these microdomains caused by saponin and methyl-beta-cyclodextrin treatment largely impairs the buoyancy and distribution of Cav2.1 channels and SNAREs in flotation gradients. Saponins 57-64 calcium voltage-gated channel subunit alpha1 A Homo sapiens 153-159 15180305-0 2004 Role of the Fas/Fas ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in HepG2 cells. Saponins 61-68 Fas ligand Homo sapiens 16-26 15180305-1 2004 This research team found in previous studies, that the ginseng saponin metabolite IH901 induces apoptosis in HepG2 cells via a mitochondrial-mediated pathway, which resulted in the activation of caspase-9 and subsequently of caspase-3 and -8. Saponins 63-70 caspase 9 Homo sapiens 195-204 15180305-1 2004 This research team found in previous studies, that the ginseng saponin metabolite IH901 induces apoptosis in HepG2 cells via a mitochondrial-mediated pathway, which resulted in the activation of caspase-9 and subsequently of caspase-3 and -8. Saponins 63-70 caspase 3 Homo sapiens 225-241 14754996-5 2004 In saponin-permeabilized myocytes IP(3) and the more potent IP(3)R agonist adenophostin increased basal [Ca(2+)](i) and the frequency of spontaneous Ca(2+) sparks. Saponins 3-10 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 60-66 15037120-3 2004 Subcellular localization of ERalpha and ERbeta was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques, as well as immunodetection of differential cellular components after subjecting the cultured cells to fractionation by sucrose gradient centrifugation. Saponins 85-92 estrogen receptor 1 Homo sapiens 28-35 15037120-3 2004 Subcellular localization of ERalpha and ERbeta was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques, as well as immunodetection of differential cellular components after subjecting the cultured cells to fractionation by sucrose gradient centrifugation. Saponins 85-92 estrogen receptor 2 Homo sapiens 40-46 15117556-1 2004 Demand for bean products is growing because of the presence of several health-promoting components in edible bean products such as saponins. Saponins 131-139 brain expressed associated with NEDD4 1 Homo sapiens 11-15 15117556-1 2004 Demand for bean products is growing because of the presence of several health-promoting components in edible bean products such as saponins. Saponins 131-139 brain expressed associated with NEDD4 1 Homo sapiens 109-113 15117556-11 2004 This study reviews the effect of thermal processing on the characteristics and stability of saponins in canned bean products. Saponins 92-100 brain expressed associated with NEDD4 1 Homo sapiens 111-115 15117556-14 2004 An optimum thermal process can increase the stability and maintain the saponins in canned bean products, which is useful for assisting the food industry to improve thermal processing technology and enhance bean product quality. Saponins 71-79 brain expressed associated with NEDD4 1 Homo sapiens 90-94 14969341-0 2004 Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Saponins 26-34 Rh associated glycoprotein Homo sapiens 50-53 15032308-10 2004 Analysis of EL4 cells by flow cytometry after Annexin V/propidium iodide staining demonstrated that saponin induced both apoptosis and necrosis. Saponins 100-107 annexin A5 Mus musculus 46-55 14761678-0 2004 A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Saponins 10-17 caspase 8 Homo sapiens 122-131 14761678-0 2004 A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Saponins 10-17 BH3 interacting domain death agonist Homo sapiens 147-150 14666768-0 2003 [Experimental study on expression of GM-CSF from human endothelial cells and monocytes induced by total saponins of panax ginseng]. Saponins 104-112 colony stimulating factor 2 Homo sapiens 37-43 14585674-5 2003 As expected for a saponin vaccine, the highest ratios were found in relation to IgG1, IgG2a and IgG2b (4.4, 5 and 2.5, respectively). Saponins 18-25 LOC105243590 Mus musculus 80-84 14585674-5 2003 As expected for a saponin vaccine, the highest ratios were found in relation to IgG1, IgG2a and IgG2b (4.4, 5 and 2.5, respectively). Saponins 18-25 immunoglobulin heavy variable V1-9 Mus musculus 86-91 14585674-5 2003 As expected for a saponin vaccine, the highest ratios were found in relation to IgG1, IgG2a and IgG2b (4.4, 5 and 2.5, respectively). Saponins 18-25 immunoglobulin heavy constant gamma 2B Mus musculus 96-101 14522442-8 2003 BUN, Cr, AST, ALT and ALP levels increased in saponin-receiving rats. Saponins 46-53 PDZ and LIM domain 3 Rattus norvegicus 22-25 14666768-1 2003 OBJECTIVE: To study the effect of total saponins of Panax ginseng (TSPG) on the expression of granulocytemacrophage colony-stimulating factor (GM-CSF) from human endothelial cells and monocytes and the relationship between TSPG and human granulocytopoiesis and monocytopoiesis modulation. Saponins 40-48 colony stimulating factor 2 Homo sapiens 143-149 14528684-3 2003 RESULTS: Total saponins from Radix Bupleuri still had antiendotoxin effect even when it (50 mg.ml-1) was diluted to 32 times by LAL test in vitro. Saponins 15-23 lysosomal acid lipase A Mus musculus 128-131 12963989-0 2003 A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Saponins 16-23 fibroblast growth factor receptor 3 Homo sapiens 72-107 12937833-0 2003 [Modulation of expression of human GM-CSF and GM-CSFRalpha by total saponins of Panax ginseng]. Saponins 68-76 colony stimulating factor 2 Homo sapiens 35-41 12937833-0 2003 [Modulation of expression of human GM-CSF and GM-CSFRalpha by total saponins of Panax ginseng]. Saponins 68-76 colony stimulating factor 2 receptor subunit alpha Homo sapiens 46-58 12721284-3 2003 Since S100A1 protein is differentially expressed in fast- and slow-twitch skeletal muscle, we used saponin-skinned murine Musculus extensor digitorum longus (EDL) and Musculus soleus (Soleus) fibers to assess the impact of S100A1 protein on SR Ca2+ release and isometric twitch force in functionally intact permeabilized muscle fibers. Saponins 99-106 S100 calcium binding protein A1 Mus musculus 6-12 12779087-4 2003 As expected from the gene sequence analysis and the biochemical features, both nucleus and cytoplasmic BRCA1 protein staining were detected in cells fixed for 60 min in 4% paraformaldehyde and permeabilized with either 0.3% saponin or 0.02% Triton. Saponins 224-231 BRCA1 DNA repair associated Homo sapiens 103-108 12526837-8 2003 The synthetic saponins increase the number of apoptotic B cells, in combination with cladribine (2-CdA), that are isolated from chronic lymphotic leukemia (B-CLL) patients. Saponins 14-22 cytidine deaminase Homo sapiens 99-102 12654630-4 2003 Activation of hMCs mediated by the high-affinity Fc receptor for immunoglobulin (Ig)E (Fc epsilon RI) increased the surface presentation of CCR3 within 1 h, with a parallel decrease in intracellular CCR3 as determined by flow cytometry on saponin-permeabilized hMCs. Saponins 239-246 Miles-Carpenter X-linked mental retardation syndrome Homo sapiens 14-18 12654630-4 2003 Activation of hMCs mediated by the high-affinity Fc receptor for immunoglobulin (Ig)E (Fc epsilon RI) increased the surface presentation of CCR3 within 1 h, with a parallel decrease in intracellular CCR3 as determined by flow cytometry on saponin-permeabilized hMCs. Saponins 239-246 Fc epsilon receptor Ia Homo sapiens 87-100 12654630-4 2003 Activation of hMCs mediated by the high-affinity Fc receptor for immunoglobulin (Ig)E (Fc epsilon RI) increased the surface presentation of CCR3 within 1 h, with a parallel decrease in intracellular CCR3 as determined by flow cytometry on saponin-permeabilized hMCs. Saponins 239-246 C-C motif chemokine receptor 3 Homo sapiens 140-144 12725562-4 2003 Saponin fraction from the roots of P. tenuifolia enhanced the production of NGF, however phenolic glycoside fraction showed no effect. Saponins 0-7 nerve growth factor Rattus norvegicus 76-79 12725562-5 2003 Onjisaponins A, B, E, F and G as major saponins of the root of P. tenuifolia strongly increased the NGF level, whereas ginsenosides Rb1 and Rg1 did not affect the NGF level. Saponins 4-12 nerve growth factor Rattus norvegicus 100-103 12459191-5 2002 The PLD inhibitor, neomycin, suppressed cAMP-dependent exocytosis in saponin-permeabilized cells. Saponins 69-76 cathelicidin antimicrobial peptide Rattus norvegicus 40-44 12417022-5 2002 Although GFP-SNAP-23 seemed to be expressed universally in the cytosol, the GFP signal was clearly seen on the plasma membrane, when soluble GFP-SNAP-23 was removed by treatment with saponin. Saponins 183-190 synaptosome associated protein 23 Homo sapiens 145-152 12588684-4 2003 Augmented L-selectin and Mac-1 expression was detected in both granulocyte populations upon saponin treatment. Saponins 92-99 L-selectin Bos taurus 10-20 11906758-2 2002 When compared to responses following immunization with antigen alone co-administration of baculovirus-expressed cat IFN-gamma significantly enhanced serum antibody titers to both viral antigens; to levels comparable with responses evoked by commonly known saponin and alum adjuvants. Saponins 256-263 interferon gamma Felis catus 116-125 12219927-10 2002 The method has been used for determination of TMS, acetyl or methyl derivatives of an aglycones released during saponin hydrolysis. Saponins 112-119 PYD and CARD domain containing Homo sapiens 46-49 12163669-5 2002 Previously, we reported that crude saponins inhibited pancreatic lipase activity in vitro. Saponins 35-43 pancreatic lipase Mus musculus 54-71 12079428-1 2002 In this study we investigated the effect of ginseng saponins on the p53-dependent apoptosis in NIH3T3 cells exposed to methyl methanesulfonate (MMS), an alkylating agent. Saponins 52-60 transformation related protein 53, pseudogene Mus musculus 68-71 12079428-4 2002 By Western blot analyses it was demonstrated that postincubation of saponins increases the expression of p53 and p21 in MMS-exposed cells but decreased that of CDK2, cyclin E and D1, and PCNA. Saponins 68-76 transformation related protein 53, pseudogene Mus musculus 105-108 12079428-4 2002 By Western blot analyses it was demonstrated that postincubation of saponins increases the expression of p53 and p21 in MMS-exposed cells but decreased that of CDK2, cyclin E and D1, and PCNA. Saponins 68-76 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 113-116 12079428-6 2002 These results suggest that ginseng saponins contain components potentiating the apoptosis of MMS-exposed NIH3T3 cells via p53 and p21 activation, accompanied with by downregulation of cell cycle-related protein expression. Saponins 35-43 transformation related protein 53, pseudogene Mus musculus 122-125 12079428-6 2002 These results suggest that ginseng saponins contain components potentiating the apoptosis of MMS-exposed NIH3T3 cells via p53 and p21 activation, accompanied with by downregulation of cell cycle-related protein expression. Saponins 35-43 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 130-133 11999345-0 2002 Modulation of the Th1/Th2 bias by lipopeptide and saponin adjuvants in orally immunized mice. Saponins 50-57 negative elongation factor complex member C/D, Th1l Mus musculus 18-21 11999345-0 2002 Modulation of the Th1/Th2 bias by lipopeptide and saponin adjuvants in orally immunized mice. Saponins 50-57 heart and neural crest derivatives expressed 2 Mus musculus 22-25 11999345-5 2002 In contrast, the saponin adjuvant enhanced both IgG2a and IgG1, and the sera showed elevated specific IgE concentrations. Saponins 17-24 immunoglobulin heavy variable V1-9 Mus musculus 48-53 11999345-5 2002 In contrast, the saponin adjuvant enhanced both IgG2a and IgG1, and the sera showed elevated specific IgE concentrations. Saponins 17-24 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 58-62 11999345-7 2002 Our data suggest that both adjuvants enhance the mucosal as well as the systemic immune response; P3CSK4 predominantly elicits the activation of the Th1 subset, whereas saponin activates both the Th1 and Th2 subser. Saponins 169-176 negative elongation factor complex member C/D, Th1l Mus musculus 196-199 11999345-7 2002 Our data suggest that both adjuvants enhance the mucosal as well as the systemic immune response; P3CSK4 predominantly elicits the activation of the Th1 subset, whereas saponin activates both the Th1 and Th2 subser. Saponins 169-176 heart and neural crest derivatives expressed 2 Mus musculus 204-207 11720987-2 2001 Expression of RyR3 restored caffeine-sensitive, global Ca(2+) release and causes the appearance of relatively frequent, spontaneous, spatially localized elevations of [Ca(2+)], as well as occasional spontaneous, propagating Ca(2+) release, in both intact and saponin-permeabilized myotubes. Saponins 259-266 ryanodine receptor 3 Homo sapiens 14-18 11969246-4 2002 Fluorescence confocal microscopy showed that the fluorescence of GFP-IP3R3 was distributed to reticular network structures, even after cell permeabilization with saponin. Saponins 162-169 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 69-74 11922485-5 2002 Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. Saponins 9-17 complement C3 Ovis aries 102-105 12673105-2 2002 (GSE) is a traditional herbal medicine that is saponin-rich. Saponins 47-54 CELIAC2 Homo sapiens 1-4 11606766-7 2001 We also demonstrate that two sodium azide-generated saponin-deficient mutants of oat, which define the Sad1 genetic complementation group, are defective in the gene encoding this enzyme and provide molecular genetic evidence indicating a direct link between AsbAS1, triterpenoid saponin biosynthesis, and disease resistance. Saponins 52-59 BR serine/threonine kinase 1 Homo sapiens 103-107 11606030-8 2001 Moreover, the saponin fraction induced apoptotic cell death of macrophages only when they were stimulated by M-CSF; it did not affect the viability of macrophages cultured without M-CSF or with granulocyte/macrophage-CSF. Saponins 14-21 colony stimulating factor 1 Homo sapiens 109-114 11606030-8 2001 Moreover, the saponin fraction induced apoptotic cell death of macrophages only when they were stimulated by M-CSF; it did not affect the viability of macrophages cultured without M-CSF or with granulocyte/macrophage-CSF. Saponins 14-21 colony stimulating factor 2 Homo sapiens 111-114 11748374-5 2001 Some partly deglycosylated saponins such as ginsenoside Rh-1, Rh-2, and Rg-3 are obtained from red ginseng as artifacts produced during steaming. Saponins 27-35 Rh associated glycoprotein Homo sapiens 62-66 11717446-5 2001 Analysis of intracellular Ca(2+) cycling in S100A1-overexpressing cardiomyocytes revealed a significant increase in cytosolic Ca(2+) transients, whereas in functional studies on saponin-permeabilized adult cardiomyocytes, the addition of S100A1 protein significantly enhanced SR Ca(2+) uptake. Saponins 178-185 S100 calcium binding protein A1 Homo sapiens 44-50 11729639-3 2001 Intestinal absorption of dietary fat was found to be reduced by tea saponin and chitosan through inhibiting pancreatic lipase activity, by chondroitin sulfate through inhibiting both pancreatic lipase activity and fatty acid absorption, and by lactosucrose through inhibiting beta-monoglyceride absorption. Saponins 68-75 pancreatic lipase Mus musculus 108-125 11535125-6 2001 Saponin treatment of MLE15 cells shifted the LPP activity, cholesterol, PC+SM and caveolin-1 from lipid microdomains to detergent-soluble fractions. Saponins 0-7 caveolin 1, caveolae protein Mus musculus 82-92 11564081-4 2001 However, flow cytometric analysis of saponin-permeabilized cells demonstrated higher levels of intracellular FasL in AA than in normal T cells (P < 0.005), both prior to and following activation with phytohaemagglutinin. Saponins 37-44 Fas ligand Homo sapiens 109-113 11312005-2 2001 The GP36 was isolated by chemical elution + sonication and used for Balb/c mouse vaccination in combination with saponin, by the s.c. route, inducing a strong and specific protective effect against experimental visceral leishmaniasis shown by the increase of: specific IgG antibodies (82.6%), mainly IgG2a, the delayed type of hypersensitivity to promastigote lysate (37.8%, P < 0.001), the in vitro cellular proliferative response to GP36 of ganglia lymphocytes (53.5%, P < 0.005) and the decrease of liver parasite burden (68.1%, P < 0.025). Saponins 113-120 podoplanin Homo sapiens 4-8 11848513-7 2001 In summary, the triterpene saponins investigated contain an apoptotic-inducing activity in A431 cells and in the case of ursolic acid it is associated with proteolytic activation of caspase-3 and/or other similar caspases. Saponins 27-35 caspase 3 Homo sapiens 182-191 11454696-4 2001 The triterpenoid saponins also partially inhibited phosphatidylinositol 3-kinase activity in Jurkat T cells in a time-dependent manner and phosphorylation in the downstream protein Akt, whereas no affect was seen on the Ras/mitogen-activated protein kinase cascade. Saponins 17-25 AKT serine/threonine kinase 1 Homo sapiens 181-184 12578629-2 2001 The main component is total saponin of panax ginseng (TSPG), which contains more than 20 ginsenosides including Rg1, Rb1 and so on. Saponins 28-35 protein phosphatase 1 regulatory subunit 3A Homo sapiens 112-115 12578629-2 2001 The main component is total saponin of panax ginseng (TSPG), which contains more than 20 ginsenosides including Rg1, Rb1 and so on. Saponins 28-35 RB transcriptional corepressor 1 Homo sapiens 117-120 11375981-6 2001 The deduced orientation of the N terminus in the cytoplasm was confirmed by immunocytochemistry on intact and saponin-permeabilized Chinese hamster ovary cells expressing recombinant rCNT1. Saponins 110-117 solute carrier family 28 member 1 Rattus norvegicus 183-188 11278574-8 2001 Activation of saponin-permeabilized platelets in the presence of the peptide led to a significant decrease of PMCA in the cytoskeleton. Saponins 14-21 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 110-114 11090099-0 2000 Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA. Saponins 15-22 MYC proto-oncogene, bHLH transcription factor Homo sapiens 92-97 11161055-1 2001 We have found that chromosaponin I (CSI), a gamma-pyronyl-triterpenoid saponin isolated from pea (Pisum sativum L. cv Alaska), specifically interacts with AUX1 protein in regulating the gravitropic response of Arabidopsis roots. Saponins 25-32 Transmembrane amino acid transporter family protein Arabidopsis thaliana 155-159 11090099-0 2000 Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA. Saponins 15-22 BCL2 apoptosis regulator Homo sapiens 108-113 11199127-3 2000 Serum AST level was significantly decreased only with total saponins (-52.2%) and ALT level was slightly modified. Saponins 60-68 transmembrane protease, serine 11d Mus musculus 6-9 11190386-2 2000 The saponins were revealed to contain three hydroxyl groups at the C-1beta, C-2alpha, and C-3beta positions in the spirostanol skeleton, and to bear a di- or triglycoside at C-3 as the common structural features. Saponins 4-12 endogenous retrovirus group K member 3 Homo sapiens 90-97 11053518-7 2000 On the other hand, the total saponin fraction of the aqueous extract inhibited pancreatic lipase activity in vitro. Saponins 29-36 pancreatic lipase Mus musculus 79-96 11501043-1 2000 AIM: To study the effects of ginseng root saponins (GRS) on interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) expression in hippocampal neurons in chronic inflammation model of aged rats. Saponins 42-50 interleukin 1 beta Rattus norvegicus 80-89 10869362-1 2000 In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. Saponins 195-202 cytochrome c oxidase subunit 8A Homo sapiens 56-59 10869362-1 2000 In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. Saponins 195-202 cytochrome c oxidase subunit 8A Homo sapiens 161-164 10927026-0 2000 Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Saponins 67-74 cytochrome c, somatic Homo sapiens 79-91 10927026-0 2000 Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Saponins 67-74 caspase 3 Homo sapiens 115-124 11043459-3 2000 Captopril also enhanced BK-induced endothelium-dependent relaxation in saponin-treated coronary rings, and GppNHp partially suppressed this enhancement. Saponins 71-78 kininogen 1 Bos taurus 24-26 10942897-6 2000 RESULTS: With 0.3% saponin as the permeabilization reagent, a significant loss of lectin labeling was observed when comparing mono PNA and triple (i.e. , B220-PNA-Bcl-2) staining (74.8% and 22.5% positive cells, respectively). Saponins 19-26 B cell leukemia/lymphoma 2 Mus musculus 163-168 10901311-16 2000 Permeabilization of the plasma membrane by saponin increased both the accumulation of doxorubicin (p < 0.05) and the cytotoxic activity of this drug in all lines, but the effects were most pronounced in the MOS/IR1 cells. Saponins 43-50 Moloney sarcoma oncogene Mus musculus 210-213 10764774-3 2000 Saponin-permeabilized COS cells transfected with type I IP(3)R showed a 50% increase in inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release at saturating [IP(3)] (10 micrometer) but no enhancement at subsaturating [IP(3)] (300 nm). Saponins 0-7 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 56-62 10901311-16 2000 Permeabilization of the plasma membrane by saponin increased both the accumulation of doxorubicin (p < 0.05) and the cytotoxic activity of this drug in all lines, but the effects were most pronounced in the MOS/IR1 cells. Saponins 43-50 immune response 1 Mus musculus 214-217 10767399-2 2000 In this paper, two novel steroidal saponins, timosaponins E1 and E2 were isolated from Anemarrhenae rhizoma, and the effects of these steroidal saponins on superoxide generation in human neutrophils were investigated. Saponins 35-43 small nucleolar RNA, H/ACA box 73A Homo sapiens 58-67 10748018-3 2000 Here we report that PAK2, a member of the Rho family of GTPase-dependent kinases, regulates isometric tension development and myosin II RLC phosphorylation in saponin permeabilized endothelial monolayers. Saponins 159-166 p21 (RAC1) activated kinase 2 Homo sapiens 20-24 10660256-5 2000 In mice, there was a preferential increase of the IgG2a subclass, and upon in vitro secondary antigen stimulation, high IL-2 and IFN-gamma levels were observed in spleen cell cultures from P. senega saponins-immunized animals. Saponins 199-207 interferon gamma Mus musculus 129-138 11192297-4 2000 Because of these issues, we investigated whether the saponin QS-21 could facilitate a reduction in dose of rIL-12 when F protein was prepared in the absence of alum (F/rIL-12). Saponins 53-60 interleukin 12B Rattus norvegicus 107-113 10594555-9 1999 Significant intracellular expression of lymphocyte LC1 was observed using the anti-LC1 MoAb 1B in saponin-permeabilized cells. Saponins 98-105 annexin A1 Homo sapiens 51-54 10594555-9 1999 Significant intracellular expression of lymphocyte LC1 was observed using the anti-LC1 MoAb 1B in saponin-permeabilized cells. Saponins 98-105 annexin A1 Homo sapiens 83-86 10594930-4 1999 Here, we examined the effect of ginseng saponins on the induction of SOD and catalase gene expression. Saponins 40-48 catalase Homo sapiens 77-85 10482563-6 1999 Using saponin-permeabilized cells coexpressing Gag and Env proteins, we obtained further evidence for Env-Gag interaction. Saponins 6-13 Pr55(Gag) Human immunodeficiency virus 1 47-50 10482563-6 1999 Using saponin-permeabilized cells coexpressing Gag and Env proteins, we obtained further evidence for Env-Gag interaction. Saponins 6-13 endogenous retrovirus group W member 1, envelope Homo sapiens 55-58 10482563-6 1999 Using saponin-permeabilized cells coexpressing Gag and Env proteins, we obtained further evidence for Env-Gag interaction. Saponins 6-13 endogenous retrovirus group W member 1, envelope Homo sapiens 102-105 10482563-6 1999 Using saponin-permeabilized cells coexpressing Gag and Env proteins, we obtained further evidence for Env-Gag interaction. Saponins 6-13 Pr55(Gag) Human immunodeficiency virus 1 106-109 10589445-4 1999 In addition, ginseng saponins treatment led to a recovery in postheparin plasma LPL activity and heparin-releasable heart LPL activity, which were markedly reduced by CPM treatment. Saponins 21-29 lipoprotein lipase Rattus norvegicus 80-83 10589445-4 1999 In addition, ginseng saponins treatment led to a recovery in postheparin plasma LPL activity and heparin-releasable heart LPL activity, which were markedly reduced by CPM treatment. Saponins 21-29 lipoprotein lipase Rattus norvegicus 122-125 10589445-6 1999 In the present study we first demonstrated that ginseng saponins sustained LPL activity at a normal level or protected LPL activity from being decreased by several factors, resulting in the decrease of serum TG and cholesterol. Saponins 56-64 lipoprotein lipase Rattus norvegicus 75-78 10589445-6 1999 In the present study we first demonstrated that ginseng saponins sustained LPL activity at a normal level or protected LPL activity from being decreased by several factors, resulting in the decrease of serum TG and cholesterol. Saponins 56-64 lipoprotein lipase Rattus norvegicus 119-122 9761744-6 1998 Most MBCD-released Thy-1 and CD59 were not sedimentable and thus differed from Thy-1 released by membrane-active cholesterol-binding agents such as saponin and streptolysin O, or Triton X-100. Saponins 148-155 Thy-1 cell surface antigen Homo sapiens 79-84 10401573-15 1999 In saponin-treated cavernous strips, the neurogenic relaxation was not affected by acetylcholine, physostigmine, atropine and vasoactive intestinal peptide (VIP) but was abolished by ODQ. Saponins 3-10 vasoactive intestinal peptide Canis lupus familiaris 157-160 10228035-2 1999 Immune-stimulating complexes (ISCOMS) containing the saponin adjuvant Quil A are potential vaccine vectors that induce a wide range of Ag-specific responses in vivo encompassing both humoral and CD4 and CD8 cell-mediated immune responses. Saponins 53-60 CD4 antigen Mus musculus 195-198 11783273-0 1999 [Effect of Panax notoginseng saponin on Ca2+, CaM in craniocerebral injury]. Saponins 29-36 calmodulin Oryctolagus cuniculus 46-49 10026225-7 1999 Measurements of fluorescence intensities and fluorescence recovery after photobleaching of the full-length myosin light chain kinase in saponin-permeable cells showed that Ca2+/calmodulin did not dissociate the kinase from these filaments. Saponins 136-143 myosin light chain kinase Rattus norvegicus 107-132 10068769-5 1999 Unfixed, solid tumor cells are permeabilized only with saponin to preserve Ki antigen. Saponins 55-62 proteasome activator subunit 3 Homo sapiens 75-85 9876141-1 1999 Avenacin A-1 is a member of a group of naturally occurring compounds called saponins. Saponins 76-84 BCL2 related protein A1 Homo sapiens 9-12 10394109-9 1999 The PT saponin induced inhibition of alpha-MG uptake was blocked by mepacrine, a phospholipase A2 inhibitor. Saponins 7-14 phospholipase A2 Oryctolagus cuniculus 81-97 10394109-11 1999 In conclusion, PT saponin inhibited, in part, alpha-MG uptake through the phospholipase A2 signal pathway in primary cultured rabbit renal PTCs. Saponins 18-25 phospholipase A2 Oryctolagus cuniculus 74-90 10470863-3 1999 The activity in permeabilized fibers after treatment with saponin, Triton X-100 and Ca(2+)-free medium reached 2.80, 6.97 and 3.32 micromol ATP min(-1) mg(-1) protein, respectively, when a coupled enzyme assay system with external hexokinase and glucose-6-phosphate dehydrogenase was used. Saponins 58-65 glucose-6-phosphate dehydrogenase Rattus norvegicus 246-279 10047984-11 1998 Endothelial cell monolayers permeabilized with saponin retract upon exposure to either Cdc42 or trypsin-activated gamma-PAK and ATP. Saponins 47-54 cell division cycle 42 Homo sapiens 87-92 10047984-11 1998 Endothelial cell monolayers permeabilized with saponin retract upon exposure to either Cdc42 or trypsin-activated gamma-PAK and ATP. Saponins 47-54 p21 (RAC1) activated kinase 2 Homo sapiens 114-123 9799125-2 1998 Apoptosis was induced by either staurosporine or ginsenoside Rh2, a ginseng saponin with a dammarane skeleton. Saponins 76-83 Rh associated glycoprotein Homo sapiens 61-64 12567527-4 1998 Its crude saponin had significant protective effect in hepatic damage caused by CCl4 in mice, its ether extract had significant analgesic effect. Saponins 10-17 chemokine (C-C motif) ligand 4 Mus musculus 80-84 10603985-3 1998 Experiments measuring tension transients in saponin-permeabilized cardiac muscles from genetically engineered mice under a variety of SR calcium loading conditions provide evidence of the functional alterations that can be achieved by manipulation of the degree of PLB inhibition of the calcium pump. Saponins 44-51 phospholamban Mus musculus 265-268 9559335-1 1998 The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine-induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Saponins 62-69 RB transcriptional corepressor 1 Mus musculus 17-20 9566961-2 1998 The intracellular orientation of apoB in the secretory pathway was confirmed by immunocytochemistry using antibodies recognizing specific domains of apoB in streptolysin-O (STP-O)- and saponin-permeabilized HepG2 cells. Saponins 185-192 apolipoprotein B Homo sapiens 33-37 9566961-2 1998 The intracellular orientation of apoB in the secretory pathway was confirmed by immunocytochemistry using antibodies recognizing specific domains of apoB in streptolysin-O (STP-O)- and saponin-permeabilized HepG2 cells. Saponins 185-192 apolipoprotein B Homo sapiens 149-153 9566961-3 1998 Lumenal epitopes on marker proteins in secretory pathway compartments (p63, p53, and galactosyltransferase) were not stained by antibodies in STP-O-treated cells, but were brightly stained in saponin-treated cells, confirming that internal membranes were not perforated in STP-O-treated cells. Saponins 192-199 sulfotransferase family 1A member 1 Homo sapiens 273-276 9566961-5 1998 Staining with this antibody was similar in STP-O- and saponin-treated cells, indicating that this epitope in apoB is exposed to the cytosol at the site of apoB synthesis and throughout most of the remaining secretory pathway. Saponins 54-61 apolipoprotein B Homo sapiens 109-113 9643450-10 1998 Our findings suggest that Rg1, a component of ginseng saponin with appropriate activity, might be a useful agent for prevention and treatment of the adverse effects of morphine. Saponins 54-61 protein phosphatase 1, regulatory subunit 3A Mus musculus 26-29 9559335-1 1998 The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine-induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Saponins 62-69 protein phosphatase 1, regulatory subunit 3A Mus musculus 25-28 9559335-3 1998 Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors. Saponins 96-103 RB transcriptional corepressor 1 Mus musculus 44-47 9559335-3 1998 Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors. Saponins 96-103 protein phosphatase 1, regulatory subunit 3A Mus musculus 52-55 9559335-3 1998 Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors. Saponins 251-258 RB transcriptional corepressor 1 Mus musculus 44-47 9559335-3 1998 Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors. Saponins 251-258 protein phosphatase 1, regulatory subunit 3A Mus musculus 52-55 9627130-7 1998 These results suggest that saponin adjuvants may be suitable for immunotherapy in humans where a Th1-type response is sought, provided that there is no pre-existing Th2-type response to the antigen. Saponins 27-34 negative elongation factor complex member C/D Homo sapiens 97-100 9422781-5 1998 First, we demonstrated that saponin, which removes cholesterol from cell membranes and allows solubilization of GPI-anchored proteins by Triton X-100, had the same effect on the GPI-anchored protein alkaline phosphatase (PLAP) in SCRLs of appropriate lipid composition. Saponins 28-35 alkaline phosphatase, placental Homo sapiens 221-225 9579049-5 1998 By this behavior and the FAB-MS spectrum, the structures of three saponins (calliandra saponin M, N and O) were established. Saponins 66-74 FA complementation group B Homo sapiens 25-28 9491761-2 1998 The antihepatotoxic activities of these saponins and glycyrrhizin (positive control) were demonstrated by measuring the levels of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT). Saponins 40-48 glutamic--pyruvic transaminase Rattus norvegicus 130-159 9491761-2 1998 The antihepatotoxic activities of these saponins and glycyrrhizin (positive control) were demonstrated by measuring the levels of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT). Saponins 40-48 glutamic--pyruvic transaminase Rattus norvegicus 161-164 9428802-8 1998 Intracellular and surface-located TPO was detected by fluorescein-labeled antibodies on saponin-treated cells. Saponins 88-95 thyroid peroxidase Homo sapiens 34-37 9400005-4 1997 In normal cells permeabilized by saponin, contraction was antagonized by antibodies against Gq/11, by the phosphatidylinositol-specific phospholipase C (PI-PLC) antagonist U 73122, but not by the phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609, or by the phospholipase D pathway inhibitor propranolol. Saponins 33-40 phospholipase C beta 1 Homo sapiens 106-151 9459177-1 1997 We have demonstrated that ginsenoside Rh2 (G-Rh2), a ginseng saponin with a dammarane skeleton, induces apoptosis of human hepatoma SK-HEP-1 cells as evidenced by analyses of DNA fragmentation, flow cytometry and changes in cell morphology. Saponins 61-68 Rh associated glycoprotein Homo sapiens 38-41 9459177-1 1997 We have demonstrated that ginsenoside Rh2 (G-Rh2), a ginseng saponin with a dammarane skeleton, induces apoptosis of human hepatoma SK-HEP-1 cells as evidenced by analyses of DNA fragmentation, flow cytometry and changes in cell morphology. Saponins 61-68 Rh associated glycoprotein Homo sapiens 45-48 9451064-12 1998 Induction of 70 kd heat shock protein content in the whole cardiac homogenate from heat-stressed rats as measured by Western immunoblotting was 5.2 +/- 1.9 (vs 0.0 in non-heat-stressed rats, p < 0.0001) and dropped to 0.0 in heat-stressed hearts treated with saponin. Saponins 262-269 selenoprotein K Rattus norvegicus 19-37 9400005-4 1997 In normal cells permeabilized by saponin, contraction was antagonized by antibodies against Gq/11, by the phosphatidylinositol-specific phospholipase C (PI-PLC) antagonist U 73122, but not by the phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor D609, or by the phospholipase D pathway inhibitor propranolol. Saponins 33-40 phospholipase C beta 1 Homo sapiens 153-159 9342944-5 1997 When the lipid peroxidation was induced by incubating rat liver microsomes with CCl4 in the presence of NADPH, the standardized saponin significantly blocked the formation of thiobarbituric acid-reactive substances at the same concentrations showing P450 inhibition in liver microsomes. Saponins 128-135 C-C motif chemokine ligand 4 Rattus norvegicus 80-84 9342944-1 1997 A possible role of cytochrome P450 (P450) inhibition by red ginseng saponins in carbon tetrachloride (CCl4)-induced lipid peroxidation was investigated in liver microsomes prepared from male Sprague Dawley rats. Saponins 68-76 C-C motif chemokine ligand 4 Rattus norvegicus 102-106 9342944-8 1997 Taken together, our present results indicated that the inhibitory effects of red ginseng saponin on P450 enzymes may have a critical role in CCl4-induced lipid peroxidation in rat liver microsomes and that the mechanism of hepatoprotection by red ginseng saponin may be distinct from that of silymarin. Saponins 89-96 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 9342944-3 1997 The standardized saponin of red ginseng showed inhibitory effects on P450-associated monooxygenase activities in a dose-dependent manner, particularly p-nitrophenol hydroxylase activity which has been known to represent CCl4-activating P450 2E1 enzyme. Saponins 17-24 C-C motif chemokine ligand 4 Rattus norvegicus 220-224 9342944-8 1997 Taken together, our present results indicated that the inhibitory effects of red ginseng saponin on P450 enzymes may have a critical role in CCl4-induced lipid peroxidation in rat liver microsomes and that the mechanism of hepatoprotection by red ginseng saponin may be distinct from that of silymarin. Saponins 255-262 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 9221915-1 1997 Ginsenoside Rb1 (Rb1), a saponin of North American ginseng (Panax quinquefolium L.), has been found to exert beneficial effects on memory and learning, putatively through its actions on the cholinergic system. Saponins 25-32 RB transcriptional corepressor 1 Rattus norvegicus 12-15 9221915-1 1997 Ginsenoside Rb1 (Rb1), a saponin of North American ginseng (Panax quinquefolium L.), has been found to exert beneficial effects on memory and learning, putatively through its actions on the cholinergic system. Saponins 25-32 RB transcriptional corepressor 1 Rattus norvegicus 17-20 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interleukin 10 Mus musculus 50-64 11038971-2 1997 Compared with oleanolic acid and sodium chloride physiological solution, the water decoction of and the total saponin in root and cortex of Aralia taibaiensis were testified to have significant protective activity in experimental acute liver injury in mice induced by CCl4. Saponins 110-117 chemokine (C-C motif) ligand 4 Mus musculus 268-272 9058601-6 1997 In LES single cells isolated by enzymatic digestion and permeabilized by saponin, 1-2-dioctanoylglycerol-mediated contraction was inhibited by preincubation with PKC-betaII antiserum but not by other PKC antisera. Saponins 73-80 protein kinase C alpha Homo sapiens 162-165 9058601-8 1997 N-Myristoylated peptides derived from the pseudosubstrate sequences of PKC isozymes were used to inhibit saponin, 1-2-dioctanoylglycerol-induced contraction of LES and ESO smooth muscle cells. Saponins 105-112 protein kinase C alpha Homo sapiens 71-74 9062701-2 1996 The apparent K(m) value for ADP with succinate as substrate, which was as high as 330 +/- 32 microM in SF in SF at 20 degrees C, decreased about 2-fold in SCF at the same temperature and in SF at 37 degrees C, and decreased further to 67 +/- 8 microM in SCF at 37 degrees C. Thus, weakening or breaking of cellular contacts by collagenase and the temperature-dependence of diffusion of substrates such as ADP, seem to be important factors that determine the respiratory activity and regulatory parameters of mitochondria in saponin-permeabilized cardiomyocytes. Saponins 524-531 KIT ligand Rattus norvegicus 155-158 9212819-5 1997 In this way, we were able to detect IL-8 with a monoclonal antibody in stimulated cells that were microwave-fixed with a combination of paraformaldehyde (4%) and glutaraldehyde (0.1%), followed by permeabilization with saponin (0.025%). Saponins 219-226 C-X-C motif chemokine ligand 8 Homo sapiens 36-40 9261947-0 1997 Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations. Saponins 92-99 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 80-85 9103461-4 1997 However, after permeabilizing these cells with saponin, a strong positive intracellular staining for gC1qR was observed by FACS, fluorescence microscopy on coverslips, and confocal laser scanning microscopic analysis. Saponins 47-54 complement C1q binding protein Homo sapiens 101-106 8958049-0 1996 Saponin adjuvant primes for a dominant interleukin-10 production to ovalbumin and to Trypanosoma cruzi antigen. Saponins 0-7 interleukin 10 Mus musculus 39-53 8958049-0 1996 Saponin adjuvant primes for a dominant interleukin-10 production to ovalbumin and to Trypanosoma cruzi antigen. Saponins 0-7 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 68-77 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interleukin 10 Mus musculus 66-71 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interferon gamma Mus musculus 81-97 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interferon gamma Mus musculus 99-108 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interferon gamma Mus musculus 218-227 8958049-3 1996 Upon in vitro secondary antigen stimulation, high interleukin-10 (IL-10) and low interferon-gamma (IFN-gamma) levels were observed in lymph node (LN) cell cultures from saponin-immunized mice in contrast with the high IFN-gamma and decreased IL-10 production by LN cells from CFA-immunized mice. Saponins 169-176 interleukin 10 Mus musculus 242-247 8958049-5 1996 Concanavalin A (Con A)-stimulated interleukin-4 (IL-4) production was higher in saponin-immunized mice than in CFA-immunized mice. Saponins 80-87 interleukin 4 Mus musculus 34-47 8958049-5 1996 Concanavalin A (Con A)-stimulated interleukin-4 (IL-4) production was higher in saponin-immunized mice than in CFA-immunized mice. Saponins 80-87 interleukin 4 Mus musculus 49-53 8958049-6 1996 IL-10 produced by LN cells from saponin-immunized mice suppressed IFN-gamma production and Con A-induced proliferation. Saponins 32-39 interleukin 10 Mus musculus 0-5 8958049-6 1996 IL-10 produced by LN cells from saponin-immunized mice suppressed IFN-gamma production and Con A-induced proliferation. Saponins 32-39 interferon gamma Mus musculus 66-75 8683457-0 1996 Comparative effects of inorganic phosphate and oxalate on uptake and release of Ca2+ by the sarcoplasmic reticulum in saponin skinned rat cardiac trabeculae. Saponins 118-125 carbonic anhydrase 2 Rattus norvegicus 80-83 8957234-4 1996 In addition, CGRP inhibited IP3-induced O2- production and transient increase in [Ca2+]i, caused by exogenous addition of IP3 in saponin-permeabilized neutrophils. Saponins 129-136 calcitonin related polypeptide alpha Homo sapiens 13-17 8759755-8 1996 Analysis of intracellularly stored CD69 in eosinophils permeabilized with saponin revealed intracellular binding of anti-CD69 Abs in all isolated eosinophils. Saponins 74-81 CD69 molecule Homo sapiens 35-39 8759755-8 1996 Analysis of intracellularly stored CD69 in eosinophils permeabilized with saponin revealed intracellular binding of anti-CD69 Abs in all isolated eosinophils. Saponins 74-81 CD69 molecule Homo sapiens 121-125 8640742-1 1996 The crude saponins from the shoots (edible part of asparagus) of asparagus (asparagus crude saponins; ACS) were found to have antitumor activity. Saponins 10-18 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 102-105 8640742-1 1996 The crude saponins from the shoots (edible part of asparagus) of asparagus (asparagus crude saponins; ACS) were found to have antitumor activity. Saponins 92-100 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 102-105 8762084-2 1996 Lipocortin 1 (LC1) immunoreactivity in murine peripheral blood leukocytes was quantified by use of a flow cytometric technique associated with a permeabilisation protocol with saponin. Saponins 176-183 annexin A1 Mus musculus 0-12 8730749-0 1996 The effects of saponin on the binding and functional properties of the human adenosine A1 receptor. Saponins 15-22 adenosine A1 receptor Homo sapiens 77-98 8607792-1 1996 Addition of GTPgammaS to saponin-permeabilised human neutrophils activated both the NADPH oxidase and phospholipase D (PLD). Saponins 25-32 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 8607792-1 1996 Addition of GTPgammaS to saponin-permeabilised human neutrophils activated both the NADPH oxidase and phospholipase D (PLD). Saponins 25-32 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 8647892-3 1996 To test this hypothesis, the properties of IP3-dependent Ca2+ release in single saponin-permeabilized HSY cells were studied by monitoring [Ca2+]s using the Ca(2+)-sensitive fluorescent dye mag-fura-2. Saponins 80-87 carbonic anhydrase 2 Homo sapiens 57-60 8766823-3 1996 We measured the instantaneous current to voltage relationship for h-erg channels using the saponin permeabilized variation of the cut-open oocyte clamp technique. Saponins 91-98 potassium voltage-gated channel subfamily H member 2 Homo sapiens 66-71 8670130-5 1996 In washed, saponin-permeabilized platelets incubated with [gamma-32P]ATP, thrombin- and phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of several proteins (66, 45, and 20kDa) was inhibited by preincubation with AS peptide (KNVVGARRSSWRVISSIEQK) based on the pseudosubstrate-like region of the 14-3-3 family. Saponins 11-18 coagulation factor II, thrombin Homo sapiens 74-82 8555271-5 1996 Namely, the saponins could induce a permeability change on liposomal membrane without cholesterol when they are glycosylated at both C-3 and C-28 of the oleanolic acid. Saponins 12-20 complement C3 Homo sapiens 133-136 8555271-7 1996 The saponins glycosylated only at C-3 could also exhibit the same activity with somewhat different action profiles when the glucuronic acid is esterified, while those with the free glucuronic acid required cholesterol in the liposomes to induce permeability change thereof. Saponins 4-12 complement C3 Homo sapiens 34-37 8666426-5 1996 Pretreatment of the cells with the cholesterol-complexing agents, saponin or digitonin, resulted in complete solubilization of Thy-1 and p56/p53lyn in non-ionic detergents and dissociation of the complexes; this implies that cholesterol plays a crucial role in stabilization of the complexes. Saponins 66-73 Thy-1 cell surface antigen Rattus norvegicus 127-132 8951688-4 1996 Significant changes in serum glucose and/or insulin occurred when the insulin was administered with 0.5% saponin, 0.5% and 1% BL-9, 0.5% and 1% dodecylmaltoside, and 0.5% and 1% tetradecylmaltoside. Saponins 105-112 insulin Canis lupus familiaris 44-51 8951688-4 1996 Significant changes in serum glucose and/or insulin occurred when the insulin was administered with 0.5% saponin, 0.5% and 1% BL-9, 0.5% and 1% dodecylmaltoside, and 0.5% and 1% tetradecylmaltoside. Saponins 105-112 insulin Canis lupus familiaris 70-77 8956502-2 1996 The Ca2+ concentration-response curves of saponin-treated left atrial skinned fibers obtained from guinea pig and rat were almost identical. Saponins 42-49 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 4-7 8666426-5 1996 Pretreatment of the cells with the cholesterol-complexing agents, saponin or digitonin, resulted in complete solubilization of Thy-1 and p56/p53lyn in non-ionic detergents and dissociation of the complexes; this implies that cholesterol plays a crucial role in stabilization of the complexes. Saponins 66-73 LYN proto-oncogene, Src family tyrosine kinase Rattus norvegicus 141-147 8666426-7 1996 Sequential treatment with saponin and Nonidet P-40 was used to fractionate tyrosine-phosphorylated proteins during Thy-1-mediated activation of RBL-2H3 cells. Saponins 26-33 Thy-1 cell surface antigen Rattus norvegicus 115-120 7622562-1 1995 The phosphorylation of regulatory myosin light chains by the Ca2+/calmodulin-dependent enzyme myosin light chain kinase (MLCK) has been shown to be essential and sufficient for initiation of endothelial cell retraction in saponin permeabilized monolayers (Wysolmerski, R. B. and D. Lagunoff. Saponins 222-229 myosin heavy chain 14 Homo sapiens 34-40 8720128-6 1995 All these results taken together suggest that (i) gp96 purified from soybeans as a GL-binding protein belongs to the LOX family; and (ii) triterpenoid saponins, including GL, are involved in the regulation of the activities of CK-II and LOXs in plants, such as soybeans and roots of liquorice, which contain large quantities of saponins. Saponins 151-159 linoleate 9S-lipoxygenase-4 Glycine max 117-120 8720128-6 1995 All these results taken together suggest that (i) gp96 purified from soybeans as a GL-binding protein belongs to the LOX family; and (ii) triterpenoid saponins, including GL, are involved in the regulation of the activities of CK-II and LOXs in plants, such as soybeans and roots of liquorice, which contain large quantities of saponins. Saponins 328-336 linoleate 9S-lipoxygenase-4 Glycine max 117-120 8824741-1 1995 The non-saponin fraction (NSF; lipophilic fraction) from the roots of Panax ginseng inhibited the aggregation of human platelets induced by thrombin (0.1 units/ml) in a dose-dependent manner. Saponins 8-15 coagulation factor II, thrombin Homo sapiens 140-148 8619322-2 1995 CGRP-LI release, and formation of the stable PGI2-metabolite 6-keto-PGF1 alpha, in response to moderate acidosis (pH 7, 6, but not 5) were significantly reduced after removal of endothelium using saponin (50 micrograms mL-1) perfusion. Saponins 196-203 L1 cell adhesion molecule Mus musculus 219-223 8845804-2 1995 In an in vitro analysis, both saponin preparations showed a significant inhibition of adhesion to fibronectin (FN) and laminin (LM) by B16-BL6 melanoma. Saponins 30-37 fibronectin 1 Mus musculus 98-109 8845804-2 1995 In an in vitro analysis, both saponin preparations showed a significant inhibition of adhesion to fibronectin (FN) and laminin (LM) by B16-BL6 melanoma. Saponins 30-37 fibronectin 1 Mus musculus 111-113 8523901-1 1995 We used the saponin Rg1 extracted from Panax ginseng to study its effects on lymphocytes of 10 young and 19 elderly persons. Saponins 12-19 protein phosphatase 1 regulatory subunit 3A Homo sapiens 20-23 7576254-0 1995 Effect of saponin from Quillaja saponaria (molina) on antibody, tumour necrosis factor and interferon-gamma production. Saponins 10-17 interferon gamma Mus musculus 91-107 7576254-7 1995 Interferon-gamma was produced only when BSA and saponin were injected together into the mice. Saponins 48-55 interferon gamma Mus musculus 0-16 7622562-1 1995 The phosphorylation of regulatory myosin light chains by the Ca2+/calmodulin-dependent enzyme myosin light chain kinase (MLCK) has been shown to be essential and sufficient for initiation of endothelial cell retraction in saponin permeabilized monolayers (Wysolmerski, R. B. and D. Lagunoff. Saponins 222-229 myosin light chain kinase Homo sapiens 94-119 7622562-1 1995 The phosphorylation of regulatory myosin light chains by the Ca2+/calmodulin-dependent enzyme myosin light chain kinase (MLCK) has been shown to be essential and sufficient for initiation of endothelial cell retraction in saponin permeabilized monolayers (Wysolmerski, R. B. and D. Lagunoff. Saponins 222-229 myosin light chain kinase Homo sapiens 121-125 8574820-4 1995 Significant changes in both serum glucose and insulin occurred when the insulin was administered with 0.5% saponin, 0.5% Brij-78, 1% BL-9 and 2% BL-9. Saponins 107-114 insulin Felis catus 46-53 7562400-2 1995 The generation of O2- from the cells induced by saponins was monitored by the reduction of cytochrome c. Saponins 48-56 cytochrome c, somatic Homo sapiens 91-103 7603461-7 1995 Gluc(2,3",4")P3 was also a full agonist for Ca2+ release, being only 10-12-fold less potent than Ins(1,4,5)P3 in saponin-permeabilized SH-SY5Y neuroblastoma cells [EC50 = 647 nM; Ins(1,4,5)P3 EC50 = 52 nM] and Madin-Darby canine kidney cells [EC50 = 2484 nM; Ins(1,4,5)P3 EC50 = 247 nM]. Saponins 113-120 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 0-4 7880721-6 1995 In MCF-7 cells the optimal pH for the ECE activity using a saponin cell permeabilisation procedure was found to residue within a narrow range of 6.2-7.26. Saponins 59-66 endothelin converting enzyme 1 Homo sapiens 38-41 8568631-3 1995 After pretreatment with saponin (50 micrograms mL-1, 3 min) to damage endothelial cells, this suppressing effect of ginsenosides was unaltered. Saponins 24-31 L1 cell adhesion molecule Mus musculus 47-58 8720437-9 1995 When fibroblasts were extracted with saponin, p53 was still associated with the actin filaments, as well as mitochondrial membranes and granular structures of the nuclear matrix. Saponins 37-44 tumor protein p53 Homo sapiens 46-49 7877136-7 1994 The antibody 960 also specifically increased insulin binding to intact, saponin-permeabilized IM-9 cell membranes. Saponins 72-79 insulin Homo sapiens 45-52 7803452-0 1994 Caffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPase. Saponins 71-78 dynein axonemal heavy chain 8 Homo sapiens 148-154 7698197-3 1994 The uptake and release of Ca2+ were explored on saponin-skinned fibres with or without cyclopiazonic acid and some results obtained were compared with those obtained with adult cremaster muscle. Saponins 48-55 carbonic anhydrase 2 Mustela putorius furo 26-29 7698197-5 1994 Furthermore, application of cyclopiazonic acid modified the twitch, the caffeine responses and decreased the amount of Ca2+ taken up by the sarcoplasmic reticulum in saponin-skinned fibres. Saponins 166-173 carbonic anhydrase 2 Mustela putorius furo 119-122 7526916-5 1994 In saponin-permeabilized platelets, we observed a marked inhibition of GTP-gamma S-stimulated PLD by many of the PTK inhibitors, consistent with the possibility that PTKs are involved in the regulation of PLD activity by a G-protein or small GTP-binding protein. Saponins 3-10 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 7851158-5 1994 This technique, which employs fixation in 1% paraformaldehyde and permeabilization with 1% saponin and 0.025% digitonin, features reliable internalization and low nonspecific binding of anti-CD3 epsilon in murine lymphoid cells, as well as tissue culture cell lines. Saponins 91-98 CD3 antigen, epsilon polypeptide Mus musculus 191-194 7851158-6 1994 The combination of saponin and digitonin treatment was also compatible with the staining of sCD3 and other lymphocyte surface antigens such as Thy1, CD4, CD8, B220, and IgM. Saponins 19-26 stearoyl-coenzyme A desaturase 3 Mus musculus 92-96 7851158-6 1994 The combination of saponin and digitonin treatment was also compatible with the staining of sCD3 and other lymphocyte surface antigens such as Thy1, CD4, CD8, B220, and IgM. Saponins 19-26 thymus cell antigen 1, theta Mus musculus 143-147 7851158-6 1994 The combination of saponin and digitonin treatment was also compatible with the staining of sCD3 and other lymphocyte surface antigens such as Thy1, CD4, CD8, B220, and IgM. Saponins 19-26 CD4 antigen Mus musculus 149-152 7851158-6 1994 The combination of saponin and digitonin treatment was also compatible with the staining of sCD3 and other lymphocyte surface antigens such as Thy1, CD4, CD8, B220, and IgM. Saponins 19-26 protein tyrosine phosphatase, receptor type, C Mus musculus 159-163 8051068-3 1994 With serum-stimulated, murine NIH/3T3 cells expressing PGHS-2, an anti-peptide antibody directed against a domain near the COOH terminus of this isozyme caused staining only after all membranes were permeabilized with 0.2% saponin; no staining occurred with 3T3 cells treated with digitonin to permeabilize only the plasma membrane. Saponins 223-230 prostaglandin-endoperoxide synthase 2 Mus musculus 55-61 7804156-0 1994 Increase in cytoskeletal actin induced by inositol 1,4-bisphosphate in saponin-permeated pig platelets. Saponins 71-78 actin alpha 2, smooth muscle Sus scrofa 25-30 7804156-1 1994 Inositol 1,4-bisphosphate (IP2) which rapidly accumulates during cell activation, strongly stimulates an increase in cytoskeletal actin in saponin-permeated platelets, and the effect is insensitive to 5"-Chloro-5"-deoxyadenosine. Saponins 139-146 actin alpha 2, smooth muscle Sus scrofa 130-135 7767884-2 1994 This response appears to be mediated by a Ca(2+)-independent isoenzyme of PKC (probably PKC epsilon), since saponin-permeabilized single ferret aortic smooth muscle cells, which retain receptor coupling, developed force in response to phenylephrine at low free [Ca2+] (pCa 7.0-8.6) and the constitutively active proteolytic fragment of PKC (PKM) elicited a contraction at pCa 7 comparable with the phenylephrine-induced contraction. Saponins 108-115 pyruvate kinase PKM Mustela putorius furo 341-344 7897590-3 1994 Although ocular instillation of insulin alone did not decrease the serum glucose concentration, instillation of insulin with absorption promoters such as EDTA and saponin decreased it. Saponins 163-170 insulin Oryctolagus cuniculus 112-119 7526916-5 1994 In saponin-permeabilized platelets, we observed a marked inhibition of GTP-gamma S-stimulated PLD by many of the PTK inhibitors, consistent with the possibility that PTKs are involved in the regulation of PLD activity by a G-protein or small GTP-binding protein. Saponins 3-10 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 205-208 8138587-1 1994 Induction paralleled the time course of morphologic change and reflected relatively specific increases in saponin-resistant p52(PAI-1) protein accumulation (approximating ten- to thirty-fold over control) and mRNA abundance (seven- to nine-fold). Saponins 106-113 similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) Rattus norvegicus 124-127 8021235-2 1994 To answer this question, we have used chemical cross-linking and immunological detection to identify the nearest neighbor(s) of arginyl-tRNA synthetase both in the isolated, purified complex and in saponin-permeabilized cells, which retain much of the structural organization of intact cells. Saponins 198-205 arginyl-tRNA synthetase 1 Homo sapiens 128-151 7522731-0 1994 Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Saponins 53-60 RB transcriptional corepressor like 2 Mus musculus 91-94 7808459-3 1994 The functional role of isozymes binding to sites of energy utilization and production characteristic of the adult myocardium can be evidenced by the functional coupling of M-CK to myofibrillar ATPase and mito-CK to translocase in Triton X-100 and saponin skinned fibers. Saponins 247-254 creatine kinase, M-type Homo sapiens 172-176 8069258-9 1994 These results suggest, first, that GRb1-m potentiates NGF-induced neurite outgrowth of chick embryonic DRGs and DRG neurons, but behaves in a slightly different manner from GRb1, and, second, that the effects of the two saponins may work primarily on neurons causing the potentiation of NGF-induced neurite outgrowth. Saponins 220-228 nerve growth factor Gallus gallus 54-57 8143783-7 1994 Permeabilization with saponin showed that the growth hormone receptor binding sites were almost exclusively present at the cell surface with little intracellularly. Saponins 22-29 growth hormone receptor Homo sapiens 46-69 8138587-1 1994 Induction paralleled the time course of morphologic change and reflected relatively specific increases in saponin-resistant p52(PAI-1) protein accumulation (approximating ten- to thirty-fold over control) and mRNA abundance (seven- to nine-fold). Saponins 106-113 serpin family E member 1 Rattus norvegicus 128-133 8138588-4 1994 Further binding of [3H]IP3 to saponin-permeabilized bovine endothelial cells reveals the presence of a single, high affinity class of IP3 receptor with a dissociation constant (Kd) of approximately 0.50 (+/- 0.03) nM. Saponins 30-37 inositol 1,4,5-trisphosphate receptor type 3 Bos taurus 134-146 7908190-0 1994 Saponin-induced release of cell-surface-anchored Thy-1 by serum glycosylphosphatidylinositol-specific phospholipase D. Saponins 0-7 thymus cell antigen 1, theta Mus musculus 49-54 7908190-0 1994 Saponin-induced release of cell-surface-anchored Thy-1 by serum glycosylphosphatidylinositol-specific phospholipase D. Saponins 0-7 glycosylphosphatidylinositol specific phospholipase D1 Mus musculus 64-117 7908190-4 1994 However, pretreatment of cells with saponin, a cholesterol-sequestering agent, rendered Thy-1 susceptible to hydrolysis. Saponins 36-43 thymus cell antigen 1, theta Mus musculus 88-93 7908190-6 1994 From experiments with reconstituted liposomes it was inferred that the effect of saponin on cells was to aid in the presentation of Thy-1 to GPI-PLD. Saponins 81-88 thymus cell antigen 1, theta Mus musculus 132-137 7908190-6 1994 From experiments with reconstituted liposomes it was inferred that the effect of saponin on cells was to aid in the presentation of Thy-1 to GPI-PLD. Saponins 81-88 glycosylphosphatidylinositol specific phospholipase D1 Mus musculus 141-148 7908190-8 1994 Rather, additional molecules in the plasma membrane are possibly involved in the presentation of Thy-1 on saponin-treated cells. Saponins 106-113 thymus cell antigen 1, theta Mus musculus 97-102 7913789-3 1994 Adenosine and 5"-chloro-5"-deoxyadenosine strongly inhibit the phosphorylation of phosphatidylinositol in dose-dependent manner, and adenosine reverses the formation of thrombin-stimulated inositol bisphosphate, which has proved to promote the polymerization of actin in saponin-permeated platelets. Saponins 271-278 coagulation factor II, thrombin Sus scrofa 169-177 8388644-1 1993 The mechanisms by which cAMP and cGMP and agents that stimulate one (isoproterenol and nitroprusside) or both cyclic nucleotides (VIP) decrease cytosolic free Ca2+ ([Ca2+]i) and inhibit contraction were examined in dispersed, intact, and saponin-permeabilized gastric muscle cells. Saponins 238-245 vasoactive intestinal peptide Homo sapiens 130-133 7508416-3 1993 Here, we show that incorporation of ovalbumin (OVA) into immune-stimulating complexes (ISCOMS) containing saponin prevents the induction of oral tolerance in mice. Saponins 106-113 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 36-45 7508416-3 1993 Here, we show that incorporation of ovalbumin (OVA) into immune-stimulating complexes (ISCOMS) containing saponin prevents the induction of oral tolerance in mice. Saponins 106-113 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 47-50 8224100-1 1993 Direct membrane injury by CCl4, in situations excluding metabolic activation, was evaluated in saponin-permeabilized hepatocytes and in microsomes by measuring immediate Ca2+ efflux. Saponins 95-102 C-C motif chemokine ligand 4 Homo sapiens 26-30 8347661-2 1993 After 30 min of incubation with saponin all lactate dehydrogenase, 50% of creatine kinase, 30% of adenylate kinase and less than 20% of citrate synthase was released into the permeabilization medium. Saponins 32-39 citrate synthase Homo sapiens 136-152 7692065-1 1993 Rabbit pancreatic acinar cells, permeabilized by saponin treatment, rapidly accumulated 3.5 nmol of Ca2+/mg protein in an energy-dependent pool when incubated at an ambient free Ca2+ concentration of 100 nM. Saponins 49-56 carbonic anhydrase 2 Oryctolagus cuniculus 100-103 7692065-1 1993 Rabbit pancreatic acinar cells, permeabilized by saponin treatment, rapidly accumulated 3.5 nmol of Ca2+/mg protein in an energy-dependent pool when incubated at an ambient free Ca2+ concentration of 100 nM. Saponins 49-56 carbonic anhydrase 2 Oryctolagus cuniculus 178-181 8503838-2 1993 PLD activity was assayed by measuring (in the presence of 1% ethanol) the accumulation of phosphatidylethanol in cells permeabilized with beta-escin, a saponin-like detergent. Saponins 152-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 8388970-2 1993 Fixation methods employing saponin as detergent resulted in accurate detection of MPO and cCD3, whereas cCD22 was detectable only after buffered-formaldehyde-acetone fixation. Saponins 27-34 myeloperoxidase Homo sapiens 82-85 8448137-4 1993 InsP3 releases 50-90% of the Ca2+ sequestered within the intracellular stores of mammalian cells permeabilized with saponin. Saponins 116-123 carbonic anhydrase 2 Homo sapiens 29-32 8237409-3 1993 Adding xanthine 0.42 mmol.L-1 and xanthine oxidase 5.4 nmol.L-1 into culture medium led to the increase of free radical content of the myocardiocytes and the decrease of action potential parameters, which were reversed by I 2 micrograms.ml-1, indicating the antioxidative action of saponin monomer I. Saponins 282-289 ribosomal protein L4 Rattus norvegicus 60-63 1331276-1 1992 To evaluate the identity of the guanosine triphosphate--binding proteins coupling arginine vasopressin receptor occupancy with activation of phospholipase C, leading to Ca2+ mobilization, and activation of phospholipase A2, leading to arachidonate release and prostanoid formation, we used intact cells, saponin-permeabilized cells, and membranes of the rat mesangial cell. Saponins 304-311 arginine vasopressin Rattus norvegicus 91-102 8380584-5 1993 Exogenously added protein kinase C (PKC) also phosphorylated MARCKS and induced its translocation in the cells permeabilized with saponin. Saponins 130-137 myristoylated alanine rich protein kinase C substrate Homo sapiens 61-67 1361726-10 1992 Permeabilization of monolayers with saponin before staining restored a labelling pattern for NEP similar to the one obtained for DPP-IV. Saponins 36-43 membrane metalloendopeptidase Homo sapiens 93-96 1478613-0 1992 Saponin effects of prolactin-like stimulation of ornithine decarboxylase activity in mouse mammary gland explants. Saponins 0-7 ornithine decarboxylase, structural 1 Mus musculus 49-72 1478613-1 1992 Saponin, a naturally occurring plant glycoside, was found to elicit a prolactin-like stimulation of ornithine decarboxylase (ODC) activity in mouse mammary gland explants. Saponins 0-7 ornithine decarboxylase, structural 1 Mus musculus 100-123 1478613-1 1992 Saponin, a naturally occurring plant glycoside, was found to elicit a prolactin-like stimulation of ornithine decarboxylase (ODC) activity in mouse mammary gland explants. Saponins 0-7 ornithine decarboxylase, structural 1 Mus musculus 125-128 1478613-2 1992 A dose-response activation of ODC was observed with saponin at concentrations between 2 and 10 micrograms/ml. Saponins 52-59 ornithine decarboxylase, structural 1 Mus musculus 30-33 1478613-4 1992 The time-course of the saponin and PRL effects on ODC activation were not different; a maximum response occurred 2-4 hours after addition of saponin. Saponins 23-30 ornithine decarboxylase, structural 1 Mus musculus 50-53 1478613-4 1992 The time-course of the saponin and PRL effects on ODC activation were not different; a maximum response occurred 2-4 hours after addition of saponin. Saponins 141-148 prolactin Mus musculus 35-38 1478613-6 1992 Finally, saponin, by itself, did not affect the rate of milk product formation, but at higher concentrations (above 0.5 microgram/ml) impaired the PRL stimulation of lipid and casein synthesis. Saponins 9-16 prolactin Mus musculus 147-150 1300040-3 1992 On normal myocardial cells, Rb1, Rb2, Rb3 20 micrograms.ml-1 inhibited the AP and spontaneous contractility, (suggesting the Ca channel blockade action of panaxadiol saponins). Saponins 166-174 RB transcriptional corepressor 1 Rattus norvegicus 28-31 1457190-2 1992 All the adjuvants induced IgG1 antibody, but saponin elicited the highest titers of IgG2a. Saponins 45-52 immunoglobulin heavy variable V1-9 Mus musculus 84-89 1457190-4 1992 All the cultures secreted IL-5, but only those from saponin-immunized mice produced IFN gamma, suggesting that saponin is capable of activating both the Th1 and TH2 T-cell subsets. Saponins 52-59 interferon gamma Mus musculus 84-93 1457190-4 1992 All the cultures secreted IL-5, but only those from saponin-immunized mice produced IFN gamma, suggesting that saponin is capable of activating both the Th1 and TH2 T-cell subsets. Saponins 52-59 negative elongation factor complex member C/D, Th1l Mus musculus 153-156 1457190-4 1992 All the cultures secreted IL-5, but only those from saponin-immunized mice produced IFN gamma, suggesting that saponin is capable of activating both the Th1 and TH2 T-cell subsets. Saponins 111-118 interferon gamma Mus musculus 84-93 1457190-4 1992 All the cultures secreted IL-5, but only those from saponin-immunized mice produced IFN gamma, suggesting that saponin is capable of activating both the Th1 and TH2 T-cell subsets. Saponins 111-118 negative elongation factor complex member C/D, Th1l Mus musculus 153-156 1446368-3 1992 To clarify the pharmacokinetics of absorption, distribution and excretion of ginsenoside Rb2 (Rb2), one of the major saponins of the root of Panax ginseng, following oral administration to rats, a tritium (3H) labeling of Rb2 was examined. Saponins 117-125 RB transcriptional corepressor like 2 Rattus norvegicus 89-92 1446368-3 1992 To clarify the pharmacokinetics of absorption, distribution and excretion of ginsenoside Rb2 (Rb2), one of the major saponins of the root of Panax ginseng, following oral administration to rats, a tritium (3H) labeling of Rb2 was examined. Saponins 117-125 RB transcriptional corepressor like 2 Rattus norvegicus 94-97 1446368-3 1992 To clarify the pharmacokinetics of absorption, distribution and excretion of ginsenoside Rb2 (Rb2), one of the major saponins of the root of Panax ginseng, following oral administration to rats, a tritium (3H) labeling of Rb2 was examined. Saponins 117-125 RB transcriptional corepressor like 2 Rattus norvegicus 94-97 1522120-7 1992 To examine further the signal transduction pathway initiated by thrombin, we developed novel conditions for minimal permeabilization of EC with saponin (4-8 micrograms/ml for 5-15 min at 37 degrees C) which allow the introduction of small extracellular molecules without the loss of large intracellular proteins and which retain thrombin-stimulated secretion. Saponins 144-151 coagulation factor II, thrombin Homo sapiens 64-72 1420290-4 1992 4 h after the in vivo administration of TDGA, the CPT-I activity in saponin-permeabilized platelets was nearly completely inhibited along with a significant reduction in the MAR induced by ADP, thrombin and ionophore A23187. Saponins 68-75 carnitine palmitoyltransferase 1B Rattus norvegicus 50-55 1420290-4 1992 4 h after the in vivo administration of TDGA, the CPT-I activity in saponin-permeabilized platelets was nearly completely inhibited along with a significant reduction in the MAR induced by ADP, thrombin and ionophore A23187. Saponins 68-75 coagulation factor II Rattus norvegicus 194-202 1300040-3 1992 On normal myocardial cells, Rb1, Rb2, Rb3 20 micrograms.ml-1 inhibited the AP and spontaneous contractility, (suggesting the Ca channel blockade action of panaxadiol saponins). Saponins 166-174 stathmin 4 Rattus norvegicus 38-41 1300197-2 1992 Saponin was found to be better than Triton X-100 for providing a new "dystrophin-enriched" solution for use in biochemical studies of the molecule. Saponins 0-7 dystrophin Gallus gallus 70-80 1740142-10 1992 In situ ADP ribosylation of beta/gamma-actin was evidenced with chicken peripheral heterophils permeabilized with saponin. Saponins 114-121 actin, gamma 2, smooth muscle, enteric Gallus gallus 33-44 1498337-6 1992 However, when the apical cell surface was pretreated with anti-TF antibody, washed, and then cells were lysed with water or permeabilized with saponin, similar augmentation of TF activity was still observed, suggesting the presence of a pool of TF to which the antibody did not initially gain access. Saponins 143-150 coagulation factor III, tissue factor Homo sapiens 176-178 1498337-6 1992 However, when the apical cell surface was pretreated with anti-TF antibody, washed, and then cells were lysed with water or permeabilized with saponin, similar augmentation of TF activity was still observed, suggesting the presence of a pool of TF to which the antibody did not initially gain access. Saponins 143-150 coagulation factor III, tissue factor Homo sapiens 176-178 1500719-4 1992 The calcium ionophore A23187 and the detergent saponin caused complete release of nonprocessed 35-kDa pro-IL-1 beta and liberation into the extracellular medium of the cytoplasmic marker enzyme LDH and the lysosomal enzyme beta-N-acetylglucosaminidase. Saponins 47-54 interleukin 1 beta Mus musculus 106-115 1819714-0 1991 Platelet-activating factor (PAF) induces contraction of saponin-skinned smooth muscle of coronary artery. Saponins 56-63 PCNA clamp associated factor Homo sapiens 0-26 1442065-9 1992 Moreover, the level of hepatic microsomal cytochrome P-450 in all mice given the two saponins were significantly increased, the liver metabolism and immunoregulating action produced by ASI and SK may be also involved in their hepato-protective effects. Saponins 85-93 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 42-58 18475487-1 1992 Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. Saponins 27-34 flotillin 2 Mus musculus 17-20 1819714-0 1991 Platelet-activating factor (PAF) induces contraction of saponin-skinned smooth muscle of coronary artery. Saponins 56-63 PCNA clamp associated factor Homo sapiens 28-31 1819714-1 1991 The effect of platelet-activating factor (PAF) on the development of isometric tension by saponin-skinned coronary artery was studied. Saponins 90-97 PCNA clamp associated factor Homo sapiens 14-40 1819714-1 1991 The effect of platelet-activating factor (PAF) on the development of isometric tension by saponin-skinned coronary artery was studied. Saponins 90-97 PCNA clamp associated factor Homo sapiens 42-45 1935970-3 1991 Stimulation of intact platelets with the Ca(2+)-ionophore A23187 or thrombin, but not phorbol 12,13-dibutyrate, decreased the subsequent pertussis-toxin-dependent ADP ribosylation of Gi alpha in saponin-permeabilized platelets in a time-dependent and dose-dependent manner. Saponins 195-202 coagulation factor II, thrombin Homo sapiens 68-76 1896087-6 1991 Translocated apo B17 is strongly associated with the membrane of the ER, being only partially releasable with alkaline carbonate, and remaining bound to the microsomes following disruption with saponin. Saponins 194-201 NADH:ubiquinone oxidoreductase subunit B6 Homo sapiens 17-20 1804549-3 1991 In order to clarify some similarities and differences of decomposition modes between 20(S)-protopanaxadiol (20(S)-ppd) saponins, represented by ginsenoside Rb1 (Rb1) and ginsenoside Rb2 (Rb2), the decompositions of Rb1 and Rb2 in the rat gastrointestinal tract, 0.1 N HCl and crude hesperidinase were investigated in detail. Saponins 119-127 RB transcriptional corepressor 1 Rattus norvegicus 156-159 1839676-2 1991 Tellurite, even at a concentration of 0.01 mM, inhibited 25 per cent of the saponin-stimulated ATPase activity of the contractile membrane protein; the inhibition increased with increasing tellurite concentration, and was reversible. Saponins 76-83 dynein axonemal heavy chain 8 Homo sapiens 95-101 1839676-3 1991 On the other hand, in erythrocytes preincubated with tellurite, the ATPase activity of the membrane contractile protein, non-stimulated by saponin, increased, and the increase was further enhanced by washing the erythrocytes. Saponins 139-146 dynein axonemal heavy chain 8 Homo sapiens 68-74 1801609-3 1991 In the sediment containing the vesicles the activity of beta-galactosidase was mostly unavailable for the substrate showing a high degree of latency: the activity became soluble after a treatment with 0.5% saponin. Saponins 206-213 galactosidase, beta 1 Rattus norvegicus 56-74 1804549-6 1991 The decomposition modes of 20(S)-ppd saponins (Rb1 and Rb2) differed from that of 20(S)-protopanaxatriol saponin (Rg1) in rat stomach. Saponins 37-45 RB transcriptional corepressor 1 Rattus norvegicus 47-50 1804549-6 1991 The decomposition modes of 20(S)-ppd saponins (Rb1 and Rb2) differed from that of 20(S)-protopanaxatriol saponin (Rg1) in rat stomach. Saponins 37-45 RB transcriptional corepressor like 2 Rattus norvegicus 55-58 1804549-8 1991 The decomposition modes of Rb1 and Rb2, both 20(S)-ppd saponins, are considered to be different because of the hydrolysis rate in the terminal sugar moiety at the C-20 hydroxyl group in the rat large intestine. Saponins 55-63 RB transcriptional corepressor 1 Rattus norvegicus 27-30 1804549-8 1991 The decomposition modes of Rb1 and Rb2, both 20(S)-ppd saponins, are considered to be different because of the hydrolysis rate in the terminal sugar moiety at the C-20 hydroxyl group in the rat large intestine. Saponins 55-63 RB transcriptional corepressor like 2 Rattus norvegicus 35-38 1804554-0 1991 Study on the cupric phenanthroline-induced beta-glucuronidase release in saponin-permeabilized polymorphonuclear leukocytes. Saponins 73-80 glucuronidase beta Homo sapiens 43-61 1804554-1 1991 Saponin-permeabilized polymorphonuclear leukocytes (PMNs) released beta-glucuronidase, a lysosomal enzyme, dose-dependently in response to cupric phenanthroline (CuPh), a mild oxidant, which catalyzes the formation of disulfide bridges. Saponins 0-7 glucuronidase beta Homo sapiens 67-85 2070820-7 1991 This increased protease activity corresponded with a 50-70% reduction in the content of the PA inhibitor-like protein p50 in both the saponin-resistant undersurface matrix and the culture medium. Saponins 134-141 nuclear factor kappa B subunit 1 Homo sapiens 118-121 1873863-6 1991 Functional activity of mitochondrial creatine kinase was determined in saponin-skinned fibers. Saponins 71-78 creatine kinase S-type, mitochondrial Oryctolagus cuniculus 23-52 1857344-1 1991 Saponin-permeabilization (30 micrograms/ml) of the platelet plasma membrane, which enables access of added compounds to mitochondrial overt carnitine palmitoyltransferase (CPT I), was applied to allow the rapid determination of CPT I activity in situ. Saponins 0-7 carnitine palmitoyltransferase 1B Rattus norvegicus 172-177 2055278-3 1991 We partially purified AChR clusters by extracting cultured rat myotubes with the cholesterol-specific detergent, saponin. Saponins 113-120 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 22-26 2045882-3 1991 AChRs were localized in surface and intracellular pools of intact and saponin-permeabilized ganglionic neurons, respectively, by using a highly sensitive immunocytochemical approach that included the binding of an anti-AChR monoclonal antibody (mAb) followed by a biotinylated secondary antibody and an avidin-biotinylated HRP complex. Saponins 70-77 cholinergic receptor nicotinic delta subunit Gallus gallus 0-4 1677198-1 1991 The localization of the human erythrocyte membrane Ins(1,3,4,5)P4 3-phosphatase was investigated by saponin permeabilization of resealed "isoionic" erythrocyte ghosts. Saponins 100-107 multiple inositol-polyphosphate phosphatase 1 Homo sapiens 51-79 1849366-9 1991 To explore a potential role for G proteins, we examined the effect of guanine nucleotide analogues on ANP-stimulated IP3 production in saponin-permeabilized cells. Saponins 135-142 natriuretic peptide A Rattus norvegicus 102-105 1722200-0 1991 Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin-permeabilized parotid acini. Saponins 64-71 calmodulin 2, pseudogene 1 Rattus norvegicus 25-30 1857344-1 1991 Saponin-permeabilization (30 micrograms/ml) of the platelet plasma membrane, which enables access of added compounds to mitochondrial overt carnitine palmitoyltransferase (CPT I), was applied to allow the rapid determination of CPT I activity in situ. Saponins 0-7 carnitine palmitoyltransferase 1B Rattus norvegicus 228-233 2011597-7 1991 A similar form of GP-2 was released from zymogen granules permeabilized with saponin and incubated in the absence of added phospholipase C. Kinetic analysis of GP-2 release at 0 degrees C and 37 degrees C suggested the presence of a granule enzyme responsible for endogenous release of GP-2 to granule contents and into the apical medium. Saponins 77-84 glycoprotein 2 Canis lupus familiaris 18-22 2018129-2 1991 PKC-beta (0.1-100 U/ml) and Ins(1,4,5)P3 (10(-9) to 10(-6) M) caused concentration-dependent contraction of IAS smooth muscle cells permeabilized by saponin. Saponins 149-156 protein kinase C beta type Oryctolagus cuniculus 0-8 1987271-3 1991 Several distinct saponins, designated QS-7, QS-17, QS-18, and QS-21, were demonstrated to boost antibody levels by 100-fold or more when used in mouse immunizations with the Ag BSA and beef liver cytochrome b5. Saponins 17-25 cytochrome b5 type A (microsomal) Mus musculus 196-209 1826634-6 1991 The use of selective agents such as oligomycin, saponin, ionomycin and biliary salts indicated that Ca2+ was stored in three different pools which are distinct from the mitochondria and from inside-out membrane vesicles. Saponins 48-55 carbonic anhydrase 2 Bos taurus 100-103 2268285-5 1990 In 45Ca2(+)-release studies it was shown that, in saponin-permeabilized insulin-exposed cells, preincubation with exogenous PGE2 or 8-bromo cyclic AMP decreased the sensitivity of 45Ca2+ release in response to Ins(1,4,5)P3, as demonstrated by an increase in the EC50 (concn. Saponins 50-57 insulin Homo sapiens 72-79 1898963-6 1991 Addition of Ins(1,4,5)P3 (10 microM) to saponin-treated (leaky) keratinocytes also resulted in a rapid release of [Ca++]i. Saponins 40-47 carbonic anhydrase 1 Mus musculus 115-121 2164048-7 1990 Inhibition by EGF is not due to an increase in inositol trisphosphate (IP3) as exposure of saponin-permeabilized cells to exogenous IP3 is without effect. Saponins 91-98 epidermal growth factor like 1 Rattus norvegicus 14-17 2120042-4 1990 However, when microsomal membranes are depleted of content by washing with saponin they are still able to co-translationally translocate and glycosylate human IFN-gamma, but the products were of higher apparent Mr than those generated by control microsomes. Saponins 75-82 interferon gamma Homo sapiens 159-168 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 5-12 prolyl 4-hydroxylase subunit beta Homo sapiens 77-105 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 5-12 prolyl 4-hydroxylase subunit beta Homo sapiens 107-110 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 5-12 interferon gamma Homo sapiens 193-202 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 5-12 prolyl 4-hydroxylase subunit beta Homo sapiens 250-253 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 206-213 prolyl 4-hydroxylase subunit beta Homo sapiens 77-105 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 206-213 prolyl 4-hydroxylase subunit beta Homo sapiens 107-110 2332454-3 1990 A threshold of 2-4 microM CD was found to be necessary to augment p52 deposition into both the secreted protein- and saponin-resistant cytomatrix (SAP) fractions of NRK cells. Saponins 117-124 similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) Rattus norvegicus 66-69 2303480-3 1990 Prior exposure of saponin-treated platelets to anti-p24/CD9 inhibited the [32P] ADP-ribosylation of the alpha 41 protein by pertussis toxin. Saponins 18-25 transmembrane p24 trafficking protein 2 Homo sapiens 52-55 2328393-11 1990 In saponin-skinned strips, application of caffeine (5-10 mM) during loading of the Ca2(+)-store increased the subsequent contraction induced by myo-inositol 1,4,5 trisphosphate (IP3, 10 microM). Saponins 3-10 carbonic anhydrase 2 Rattus norvegicus 83-86 2303480-3 1990 Prior exposure of saponin-treated platelets to anti-p24/CD9 inhibited the [32P] ADP-ribosylation of the alpha 41 protein by pertussis toxin. Saponins 18-25 CD9 molecule Homo sapiens 56-59 2289622-2 1990 Cultured mesenchymal cells respond to hyperoxic (hyper-O2) stress with increased cell flattening/substrate adhesion and overall 47-69% reductions in total matrix-associated (i.e. saponin-resistant [SAP fraction]) protein. Saponins 179-186 amyloid P component, serum Homo sapiens 198-201 1968781-5 1990 Clathrin plaques remain after AChR domains are disrupted by azide, or after microfilament bundles are destabilized by cytochalasin D. Extraction of myotubes with saponin removes clathrin without disrupting AChR domains. Saponins 162-169 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 30-34 1968781-5 1990 Clathrin plaques remain after AChR domains are disrupted by azide, or after microfilament bundles are destabilized by cytochalasin D. Extraction of myotubes with saponin removes clathrin without disrupting AChR domains. Saponins 162-169 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 206-210 2104768-8 1990 The effects of DPPE and HDC inhibitors are significantly reversed by the addition of histamine (0.1 to 10 mumol/L) to saponin-permeabilized platelets, though histamine alone has no pro-aggregatory effects. Saponins 118-125 histidine decarboxylase Homo sapiens 24-27 33761611-4 2021 In this study, we investigated the effect of the saponin fraction isolated from sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) leaves on the viability of HL-60 cancer cells using resazurin assay and its ability to induction of apoptosis with Annexin V-FITC and propidium iodide (PI) double staining. Saponins 49-56 annexin A5 Homo sapiens 247-256 33762943-3 2021 Our previous study has reported that Panax notoginseng saponins (PNS) protection against thapsigargin (TG)-induced ER stress response and associated cell apoptosis in cardiac myocytes is calcium dependent and mediated by ER Ca2+ release through RyR2. Saponins 55-63 ryanodine receptor 2 Rattus norvegicus 245-249 34933095-0 2022 Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP2-Mediated mitophagy. Saponins 9-17 NLR family, pyrin domain containing 3 Mus musculus 26-31 11410334-0 2001 Saponin permeabilization of rough microsomes from rat liver reveals a novel prothrombin pool. Saponins 0-7 coagulation factor II Rattus norvegicus 76-87 11410334-1 2001 Saponin permeabilization of rough microsomes in the presence of high salt revealed a novel pool of prothrombin associated by ionic interactions to the microsomal membrane. Saponins 0-7 coagulation factor II Rattus norvegicus 99-110 11410334-3 2001 By a subsequent treatment with 0.32% saponin in a slightly alkaline high salt buffer a fraction of peripherally associated membrane prothrombin was released from rough microsomes. Saponins 37-44 coagulation factor II Rattus norvegicus 132-143 34798409-0 2022 Dammarane-type saponins with proprotein convertase subtilisin/kexin type 9 inhibitory activity from Gynostemma pentaphyllum. Saponins 15-23 proprotein convertase subtilisin/kexin type 9 Homo sapiens 29-74 34952766-8 2022 The studies included in the review showed that the saponins and sapogenins were anti-inflammatory, antinociceptive and antioxidant and they modulate inflammatory cytokines mainly through the Nf-kappaB, TLR4 and MAPKs pathways. Saponins 51-59 nuclear factor kappa B subunit 1 Homo sapiens 191-200 34952766-8 2022 The studies included in the review showed that the saponins and sapogenins were anti-inflammatory, antinociceptive and antioxidant and they modulate inflammatory cytokines mainly through the Nf-kappaB, TLR4 and MAPKs pathways. Saponins 51-59 toll like receptor 4 Homo sapiens 202-206 34943071-0 2021 Crude Saponin from Platycodon grandiflorum Attenuates Abeta-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways. Saponins 6-13 amyloid beta (A4) precursor protein Mus musculus 54-59 34655668-0 2022 A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway. Saponins 33-40 AKT serine/threonine kinase 1 Homo sapiens 146-149 34655668-0 2022 A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway. Saponins 33-40 mechanistic target of rapamycin kinase Homo sapiens 150-154 34697654-6 2022 The results showed that six saponins, including ginsenoside Rh4, ginsenoside Rk3, ginsenoside Rg5, ginsenoside Rk1, ginsenoside Rg6, and 20(S)-ginsenoside Rh2, were significantly different between the two groups. Saponins 28-36 kallikrein 1-related peptidase B3 Rattus norvegicus 111-114 34624452-0 2022 Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-kappaB and Ang/Tie-2 pathways. Saponins 0-8 TNF receptor superfamily member 11B Rattus norvegicus 105-108 34624452-0 2022 Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-kappaB and Ang/Tie-2 pathways. Saponins 0-8 TNF superfamily member 11 Rattus norvegicus 109-114 34624452-0 2022 Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-kappaB and Ang/Tie-2 pathways. Saponins 0-8 angiogenin Rattus norvegicus 129-132 34624452-0 2022 Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-kappaB and Ang/Tie-2 pathways. Saponins 0-8 TEK receptor tyrosine kinase Rattus norvegicus 133-138 34974155-6 2022 The moderate to high survivability demonstrated by the Sa-adjuvanted IV vaccine, was substantiated by the significant (p < 0.05) upregulation of IL-1beta, Mx and PKR gene transcript. Saponins 55-57 interleukin 1 alpha Homo sapiens 145-153 34974155-6 2022 The moderate to high survivability demonstrated by the Sa-adjuvanted IV vaccine, was substantiated by the significant (p < 0.05) upregulation of IL-1beta, Mx and PKR gene transcript. Saponins 55-57 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 162-165 34943071-2 2021 We investigated whether P. grandiflorum crude saponin (PGS) protects neurons from neurodegeneration caused by amyloid beta (Abeta)-induced oxidative stress. Saponins 46-53 amyloid beta (A4) precursor protein Mus musculus 124-129 34665516-1 2021 Ginsenosides, including Rb 1 , Rb 2 , Rb 3 and Rc, belong to protopanaxadiol-type saponins in Panax ginseng C. A. Mey. Saponins 82-90 RB transcriptional corepressor 1 Homo sapiens 24-28 34828872-8 2021 While much has been published in relation to oat nutrients and oat fibers and their impact on major diseases, the oat industries and consumers may benefit from greater knowledge and understanding of clinical effects, range of occurrence, distribution, therapeutic doses and food functional attributes of other oat bioactives such as avenanthramides and saponins as well as other anti-inflammatory agents found in the cereal. Saponins 353-361 ornithine aminotransferase Homo sapiens 114-117 34174648-0 2021 Development of pH-driven zein/tea saponin composite nanoparticles for encapsulation and oral delivery of curcumin. Saponins 34-41 phenylalanine hydroxylase Homo sapiens 15-17 34751072-7 2021 The results showed that dietary saponins exerted anti-cancer activities via regulation of apoptosis, autophagy, arrest cell cycle, anti-proliferation, anti-metastasis, and anti-angiogenesis, by regulation of several critical signaling pathways, including MAPK, PI3K/Akt/mTOR, NF-kappaB, and VEGF/VEGFR. Saponins 32-40 AKT serine/threonine kinase 1 Homo sapiens 266-269 34751072-7 2021 The results showed that dietary saponins exerted anti-cancer activities via regulation of apoptosis, autophagy, arrest cell cycle, anti-proliferation, anti-metastasis, and anti-angiogenesis, by regulation of several critical signaling pathways, including MAPK, PI3K/Akt/mTOR, NF-kappaB, and VEGF/VEGFR. Saponins 32-40 mechanistic target of rapamycin kinase Homo sapiens 270-274 34751072-7 2021 The results showed that dietary saponins exerted anti-cancer activities via regulation of apoptosis, autophagy, arrest cell cycle, anti-proliferation, anti-metastasis, and anti-angiogenesis, by regulation of several critical signaling pathways, including MAPK, PI3K/Akt/mTOR, NF-kappaB, and VEGF/VEGFR. Saponins 32-40 vascular endothelial growth factor A Homo sapiens 291-295 34751072-7 2021 The results showed that dietary saponins exerted anti-cancer activities via regulation of apoptosis, autophagy, arrest cell cycle, anti-proliferation, anti-metastasis, and anti-angiogenesis, by regulation of several critical signaling pathways, including MAPK, PI3K/Akt/mTOR, NF-kappaB, and VEGF/VEGFR. Saponins 32-40 kinase insert domain receptor Homo sapiens 296-301 34385105-0 2021 Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1alpha/BNIP3 to inhibit mitochondrial apoptosis pathway. Saponins 18-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-100 34771191-2 2021 Herein, BP was chemically functionalized by aliphatic amine (DETA), aromatic amine (PPDA) and cyclamine (Pid) via a nucleophilic substitution reaction, aiming to develop an intensively reactive BP flame retardant for epoxy resin (EP). Saponins 94-103 metastasis associated 1 family member 2 Homo sapiens 105-108 34771191-2 2021 Herein, BP was chemically functionalized by aliphatic amine (DETA), aromatic amine (PPDA) and cyclamine (Pid) via a nucleophilic substitution reaction, aiming to develop an intensively reactive BP flame retardant for epoxy resin (EP). Saponins 94-103 epiregulin Homo sapiens 230-232 34690763-4 2021 In vivo, we found that Panax notoginseng saponins (PNS) could inhibit tumor growth and significantly downregulate the expression and phosphorylation of ATP1A1/AKT/ERK in tumor-bearing mice. Saponins 41-49 AKT serine/threonine kinase 1 Homo sapiens 159-162 34690763-4 2021 In vivo, we found that Panax notoginseng saponins (PNS) could inhibit tumor growth and significantly downregulate the expression and phosphorylation of ATP1A1/AKT/ERK in tumor-bearing mice. Saponins 41-49 mitogen-activated protein kinase 1 Homo sapiens 163-166 34721647-0 2021 Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF-kappaB Signaling Pathway. Saponins 6-13 toll like receptor 4 Homo sapiens 117-121 34721647-0 2021 Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF-kappaB Signaling Pathway. Saponins 6-13 nuclear factor kappa B subunit 1 Homo sapiens 122-131 34721647-2 2021 This study aims to investigate whether the total saponin of Dioscorea collettii (TSD) can attenuate monosodium urate (MSU) crystal-induced inflammatory effects by suppressing the activation of the TLR4/NF-kappaB signaling pathway in vivo and in vitro. Saponins 49-56 toll like receptor 4 Homo sapiens 197-201 34721647-2 2021 This study aims to investigate whether the total saponin of Dioscorea collettii (TSD) can attenuate monosodium urate (MSU) crystal-induced inflammatory effects by suppressing the activation of the TLR4/NF-kappaB signaling pathway in vivo and in vitro. Saponins 49-56 nuclear factor kappa B subunit 1 Homo sapiens 202-211 34690763-4 2021 In vivo, we found that Panax notoginseng saponins (PNS) could inhibit tumor growth and significantly downregulate the expression and phosphorylation of ATP1A1/AKT/ERK in tumor-bearing mice. Saponins 41-49 ATPase Na+/K+ transporting subunit alpha 1 Homo sapiens 152-158 34343036-5 2021 The saponin and two flavonoid glycosides displayed non-selective antiplasmodial activity at 50 microg/mL but the activities were diminished at 10 microg/mL. Saponins 4-11 thrombopoietin Mus musculus 153-155 34129896-0 2021 Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors. Saponins 0-8 NLR family, pyrin domain containing 3 Mus musculus 90-95 34440920-1 2021 Since the signal transducer and activator of transcription 3 (STAT3)/programmed death-ligand 1 (PD-L1) signaling plays an important role in tumor-immune microenvironments, in the present study, the role of STAT3/PD-L1 signaling in the apoptotic mechanism of an active ginseng saponin metabolite compound K (CK) was investigated in human prostate cancer cells. Saponins 276-283 signal transducer and activator of transcription 3 Homo sapiens 62-67 34440920-1 2021 Since the signal transducer and activator of transcription 3 (STAT3)/programmed death-ligand 1 (PD-L1) signaling plays an important role in tumor-immune microenvironments, in the present study, the role of STAT3/PD-L1 signaling in the apoptotic mechanism of an active ginseng saponin metabolite compound K (CK) was investigated in human prostate cancer cells. Saponins 276-283 CD274 molecule Homo sapiens 96-101 34440920-1 2021 Since the signal transducer and activator of transcription 3 (STAT3)/programmed death-ligand 1 (PD-L1) signaling plays an important role in tumor-immune microenvironments, in the present study, the role of STAT3/PD-L1 signaling in the apoptotic mechanism of an active ginseng saponin metabolite compound K (CK) was investigated in human prostate cancer cells. Saponins 276-283 signal transducer and activator of transcription 3 Homo sapiens 206-211 34506766-0 2021 A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells. Saponins 18-25 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 0-4 34581940-0 2022 Total Saponins of Panax notoginseng Activate Akt/mTOR Pathway and Exhibit Neuroprotection in vitro and in vivo against Ischemic Damage. Saponins 6-14 AKT serine/threonine kinase 1 Homo sapiens 45-48 34581940-0 2022 Total Saponins of Panax notoginseng Activate Akt/mTOR Pathway and Exhibit Neuroprotection in vitro and in vivo against Ischemic Damage. Saponins 6-14 mechanistic target of rapamycin kinase Homo sapiens 49-53 34604348-0 2021 Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Saponins 37-45 thymoma viral proto-oncogene 1 Mus musculus 145-148 34604348-0 2021 Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Saponins 37-45 mechanistic target of rapamycin kinase Mus musculus 149-153 34354001-0 2021 Panax notoginseng saponins protect H9c2 cells from hypoxia-reoxygenation injury through FOXO3a/HIF-1alpha cell signaling pathway. Saponins 18-26 forkhead box O3 Rattus norvegicus 88-94 34354001-0 2021 Panax notoginseng saponins protect H9c2 cells from hypoxia-reoxygenation injury through FOXO3a/HIF-1alpha cell signaling pathway. Saponins 18-26 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 95-105 34451648-6 2021 Through a pharmacological and microscopic approach, it was underlined that this saponin modified both auxin distribution and transport, causing an auxin accumulation in the region of root maturation and an alteration of proteins responsible for the auxin efflux (PIN2). Saponins 80-87 Auxin efflux carrier family protein Arabidopsis thaliana 263-267 34343036-5 2021 The saponin and two flavonoid glycosides displayed non-selective antiplasmodial activity at 50 microg/mL but the activities were diminished at 10 microg/mL. Saponins 4-11 thrombopoietin Mus musculus 102-104 34062240-0 2021 Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota. Saponins 0-8 complement component 3 Mus musculus 69-82 34236031-0 2021 (Panax notoginseng saponins inhibit proliferation, migration, invasion and promote apoptosis of U2OS osteosarcoma cells via blocking Notch1 pathway). Saponins 19-27 notch receptor 1 Homo sapiens 133-139 34132431-1 2021 In the current study, the pivotal roles of serum and glucocorticoid-induced protein kinase (SGK1) and NF-kB related signalings known as prognostic biomarkers in cervical cancers were explored in the antitumor effect of a ginseng saponin metabolite compound K (CK) in HeLa and SiHa cervical cancer cells. Saponins 229-236 serum/glucocorticoid regulated kinase 1 Homo sapiens 92-96 34078669-3 2021 Although PRR independent adjuvants (e.g., oil-in-water emulsion and saponin) are emerging, these adjuvants induce some local and systemic reactogenicity. Saponins 68-75 nectin cell adhesion molecule 1 Mus musculus 9-12 34071663-1 2021 Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins, such as ginsenoside Rb1, Rb2, Rc, and Rd. Saponins 87-95 cytidine/uridine monophosphate kinase 1 Homo sapiens 12-14 34071663-1 2021 Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins, such as ginsenoside Rb1, Rb2, Rc, and Rd. Saponins 87-95 RB transcriptional corepressor 1 Homo sapiens 117-120 33973571-7 2021 Saponin-permeabilized parasites were analyzed to obtain the ratio of green/yellow fluorescence intensity (Rgy) plotted as a function of pH in a pH calibration curve of FITC-dextran. Saponins 0-7 phenylalanine hydroxylase Homo sapiens 136-138 33973571-7 2021 Saponin-permeabilized parasites were analyzed to obtain the ratio of green/yellow fluorescence intensity (Rgy) plotted as a function of pH in a pH calibration curve of FITC-dextran. Saponins 0-7 phenylalanine hydroxylase Homo sapiens 144-146 34071663-1 2021 Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins, such as ginsenoside Rb1, Rb2, Rc, and Rd. Saponins 87-95 RB transcriptional corepressor like 2 Homo sapiens 122-125 35307576-14 2022 The bile acids and saponins are most likely related to the anti-NLRP3 inflammasome activation effect of BBD. Saponins 19-27 NLR family, pyrin domain containing 3 Mus musculus 64-69 35595219-2 2022 Ginsenoside Rg1 is a saponin isolated and purified from ginseng that exerts protective effects on the liver in some liver injury models. Saponins 21-28 protein phosphatase 1, regulatory subunit 3A Mus musculus 12-15 34070219-7 2021 Cycloastragenol (CAG), an extract of saponins, stimulates telomerase enzymes and enhances KLB expression and alleviates age-related deterioration in cultured primary bovine granulosa cells. Saponins 37-45 klotho beta Bos taurus 90-93 34068075-12 2021 Moreover, the saponins cake extract showed a strong inhibitory action on alpha-amylase and alpha-glucosidase, which is also higher than that of Argan oil. Saponins 14-22 sucrase isomaltase (alpha-glucosidase) Mus musculus 91-108 34556263-0 2021 Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway. Saponins 0-8 AKT serine/threonine kinase 1 Rattus norvegicus 103-106 34556263-0 2021 Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway. Saponins 0-8 forkhead box O1 Rattus norvegicus 107-112 34556263-7 2021 First, saponins increased the mRNA and protein levels of IRS-2 but decreased the serine 731 phosphorylation level of IRS-2. Saponins 7-15 insulin receptor substrate 2 Rattus norvegicus 57-62 34556263-7 2021 First, saponins increased the mRNA and protein levels of IRS-2 but decreased the serine 731 phosphorylation level of IRS-2. Saponins 7-15 insulin receptor substrate 2 Rattus norvegicus 117-122 34556263-8 2021 Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. Saponins 10-18 AKT serine/threonine kinase 1 Rattus norvegicus 52-55 34556263-8 2021 Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. Saponins 10-18 forkhead box O1 Rattus norvegicus 99-104 34556263-9 2021 Furthermore, saponins increased the protein level of the downstream molecule and insulin initiating factor PDX-1, which was also reversed by ly294002. Saponins 13-21 pancreatic and duodenal homeobox 1 Rattus norvegicus 107-112 34556263-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 AKT serine/threonine kinase 1 Rattus norvegicus 24-27 34556263-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 pancreatic and duodenal homeobox 1 Rattus norvegicus 32-37 34556263-10 2021 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. Saponins 0-8 forkhead box O1 Rattus norvegicus 57-62 34556263-13 2021 In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway. Saponins 130-138 AKT serine/threonine kinase 1 Rattus norvegicus 183-186 34556263-13 2021 In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway. Saponins 130-138 forkhead box O1 Rattus norvegicus 187-192 35371298-0 2022 Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b. Saponins 24-32 myosin regulatory light chain interacting protein Homo sapiens 88-91 35630692-9 2022 Hydrolyzed saponins already degrade erythrocytes at 20 microg mL-1, whereas 100 microg mL-1 of transesterified saponins is needed to induce detectable activity. Saponins 11-19 L1 cell adhesion molecule Mus musculus 62-66 35630692-9 2022 Hydrolyzed saponins already degrade erythrocytes at 20 microg mL-1, whereas 100 microg mL-1 of transesterified saponins is needed to induce detectable activity. Saponins 111-119 L1 cell adhesion molecule Mus musculus 87-91 35600780-0 2022 Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-kappaB and AP-1 pathways. Saponins 19-26 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 86-95 35600780-0 2022 Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-kappaB and AP-1 pathways. Saponins 19-26 jun proto-oncogene Mus musculus 100-104 35634375-1 2022 Ginsenoside Rb1, a diol-type ginseng saponin, has various positive effects on the central nervous system. Saponins 37-44 RB transcriptional corepressor 1 Mus musculus 12-15 35600856-1 2022 Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity. Saponins 70-77 Rh associated glycoprotein Homo sapiens 12-15 35371298-0 2022 Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b. Saponins 24-32 microRNA let-7b Homo sapiens 92-98 35131955-2 2022 In a previous study, a GH39 beta-xylosidase Xln-DT was responsible for the bioconversion of saponin, a natural active substance with a xylose group, with high selectivity for cleaving the outer xylose moiety of notoginsenoside R1 at the C-6 position, producing ginsenoside Rg1 with potent anti-fatigue activity. Saponins 92-99 protein phosphatase 1, regulatory subunit 3A Mus musculus 273-276 35179617-7 2022 Both TC2 and SS diffused through pig ear skin and traces of TC2 (but not SS) were detected in the stratum corneum of mice at 6-24 h. Neither TC2 nor SS was detected in plasma. Saponins 13-15 transcobalamin 2 Mus musculus 60-63 35389397-6 2022 CB1 and MKP-1 are the targets of the glucocorticoid-like effect of saponins. Saponins 67-75 cannabinoid receptor 1 (brain) Mus musculus 0-3 35389397-6 2022 CB1 and MKP-1 are the targets of the glucocorticoid-like effect of saponins. Saponins 67-75 dual specificity phosphatase 1 Mus musculus 8-13 35385194-0 2022 Panax notoginseng saponins improves healing of high glucose-induced wound through the GSK-3beta/beta-catenin pathway. Saponins 18-26 glycogen synthase kinase 3 alpha Rattus norvegicus 86-95 35455695-0 2022 Decrease of Hyaluronidase Activity and Suppression of Mouse CD4+ T Lymphocyte Activation by Tomato Juice Saponin Esculeoside B, and Its Sapogenol Esculeogenin B. Saponins 105-112 CD4 antigen Mus musculus 60-63 35385194-0 2022 Panax notoginseng saponins improves healing of high glucose-induced wound through the GSK-3beta/beta-catenin pathway. Saponins 18-26 catenin beta 1 Rattus norvegicus 96-108 35156801-7 2022 Finally, we found that aligned saponin nanodiscs provide a sufficient alignment medium to allow the measurement of residual dipolar couplings (RDCs) in aqueous cytochrome c. Saponins 31-38 cytochrome c, somatic Homo sapiens 160-172 35262106-2 2022 Our previous studies showed that the aqueous extract of ESL enhanced memory in mice, and its saponin fraction (ESL-SAP) exhibited promising neuroprotective activities in vitro; however, the in vivo neurally related effect, bioactive material basis, and possible mechanism of action of ESL-SAP have not been investigated. Saponins 93-100 SH2 domain containing 1A Mus musculus 115-118 35262106-4 2022 Furthermore, an in vivo saponin library-guided pseudotargeted strategy was established to support the rapid monitoring of 26 blood-brain barrier (BBB)-permeated saponins from ESL-SAP-administered rats. Saponins 24-31 amyloid P component, serum Rattus norvegicus 179-182 35262106-4 2022 Furthermore, an in vivo saponin library-guided pseudotargeted strategy was established to support the rapid monitoring of 26 blood-brain barrier (BBB)-permeated saponins from ESL-SAP-administered rats. Saponins 161-169 amyloid P component, serum Rattus norvegicus 179-182 35074343-0 2022 Panax notoginseng saponins induce apoptosis in retinoblastoma Y79 cells via the PI3K/AKT signalling pathway. Saponins 18-26 AKT serine/threonine kinase 1 Homo sapiens 85-88 35573878-9 2022 This bioactive molecular network provided a panoramic view of FJHQD"s ACE inhibitory activities, which demonstrated that flavones from Astragali Radix and Glycyrrhizae Radix et Rhizoma, saponins from Astragali Radix, and sesquiterpenoids from Atractylodis Macrocephalae Rhizoma were principal components responsible for this effect of FJHQD. Saponins 186-194 angiotensin I converting enzyme Homo sapiens 70-73 35215495-12 2022 PM exposure resulted in increased expression of leptin, which was reduced by saponins. Saponins 77-85 leptin Homo sapiens 48-54 35215495-15 2022 CONCLUSION: Saponins of KRG can protect the skin from the harmful effects of PM exposure by reducing levels of ROS, leptin, inflammatory cytokines, and melanin. Saponins 12-20 leptin Homo sapiens 116-122 35136538-1 2022 Objective: To analyze the clinical observation of salvianolic acid combined with panax notoginseng saponins combined with basic nursing intervention on cerebral ischemia-reperfusion injury in rats and its effects on the expression of apoptosis-related proteins Bcl-2, Bax and caspase-3. Saponins 99-107 BCL2, apoptosis regulator Rattus norvegicus 261-266 35119449-0 2022 S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation. Saponins 18-25 ribosomal protein S20 Homo sapiens 0-4 35022006-0 2022 Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes. Saponins 18-26 phosphoglycolate phosphatase Mus musculus 35-39 35022006-0 2022 Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes. Saponins 18-26 sirtuin 1 Mus musculus 116-121 35022006-0 2022 Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes. Saponins 18-26 forkhead box O1 Mus musculus 122-127 35022006-0 2022 Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes. Saponins 18-26 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 128-132 2530284-2 1989 The cells were then fixed and subsequently permeabilized in suspension by the detergent saponin in order to enable TNF alpha- or TNF beta-specific antibodies to enter the cells and interact with cytoplasmic TNF in producer cells. Saponins 88-95 tumor necrosis factor Homo sapiens 115-124 35071373-0 2021 Corrigendum: Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Deprivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Saponins 50-58 thymoma viral proto-oncogene 1 Mus musculus 159-162 35071373-0 2021 Corrigendum: Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Deprivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Saponins 50-58 mechanistic target of rapamycin kinase Mus musculus 163-167 2530284-2 1989 The cells were then fixed and subsequently permeabilized in suspension by the detergent saponin in order to enable TNF alpha- or TNF beta-specific antibodies to enter the cells and interact with cytoplasmic TNF in producer cells. Saponins 88-95 tumor necrosis factor Homo sapiens 115-118 2508056-0 1989 Calmodulin loss in vascular smooth muscle following Triton X-100 or saponin skinning. Saponins 68-75 calmodulin 1 Rattus norvegicus 0-10 2508056-5 1989 Permeabilization of the plasmalemma with 0.15 mg/ml saponin or 0.5% Triton X-100 caused significant detergent-dependent loss of CaM. Saponins 52-59 calmodulin 1 Rattus norvegicus 128-131 2508056-6 1989 At the end of a 1 h skinning period, tissues exposed to saponin lost 30% of total CaM. Saponins 56-63 calmodulin 1 Rattus norvegicus 82-85 2508056-10 1989 The diffusible CaM component of saponin skinned tissue (59%) was significantly less than the diffusible component of those skinned with Triton X-100 (88%); however, the rate coefficients for CaM diffusion (0.78 h-1 and 0.91 h-1, respectively) did not statistically differ. Saponins 32-39 calmodulin 1 Rattus norvegicus 15-18 2508056-11 1989 The nondiffusible component of CaM was significantly larger in saponin treated strips (42%) than in Triton X-100 permeabilized tissue (12%). Saponins 63-70 calmodulin 1 Rattus norvegicus 31-34 2788653-7 1989 In saponin-permeabilized hepatocytes, tBuBHQ released Ca2+ from the same nonmitochondrial, ATP-dependent Ca2+ pool which was released by inositol 1,4,5-trisphosphate. Saponins 3-10 carbonic anhydrase 2 Rattus norvegicus 54-57 2788653-8 1989 Furthermore, tBuBHQ-induced Ca2+ release in saponin-permeabilized cells was not inhibited by neomycin, and tBuBHQ did not produce any apparent accumulation of inositol phosphates in intact hepatocytes. Saponins 44-51 carbonic anhydrase 2 Rattus norvegicus 28-31 2798038-4 1989 In cells loaded to isotopic equilibrium with 45Ca, bradykinin increased the 45Ca efflux into both calcium-containing and calcium-free solutions, with an EC50 for the increase in 45Ca efflux induced by bradykinin of 1.3 x 10(-9) M. The involvement of an intracellular Ca2+ store and the participation of a second messenger in its release were investigated in saponin-permeabilized endothelial cells. Saponins 358-365 kininogen 1 Bos taurus 51-61 2798038-4 1989 In cells loaded to isotopic equilibrium with 45Ca, bradykinin increased the 45Ca efflux into both calcium-containing and calcium-free solutions, with an EC50 for the increase in 45Ca efflux induced by bradykinin of 1.3 x 10(-9) M. The involvement of an intracellular Ca2+ store and the participation of a second messenger in its release were investigated in saponin-permeabilized endothelial cells. Saponins 358-365 kininogen 1 Bos taurus 201-211 2515819-13 1989 Furthermore, the Cu2(+)-contracture was inhibited by exposing the outer membrane to trypsin, phospholipase C or saponin. Saponins 112-119 immunoglobulin kappa variable 1-35 Mus musculus 17-20 2732247-7 1989 Extraction of triads with low concentrations of saponin or sodium dodecyl sulfate completely removes albumin without removing intrinsic membrane proteins. Saponins 48-55 albumin Oryctolagus cuniculus 101-108