PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21186359-5 2011 Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Octbeta2R octopamine autoreceptors. Octopamine 10-20 Cyclic-AMP response element binding protein A Drosophila melanogaster 62-66 21186359-7 2011 In addition, octopamine neurons regulated the expansion of excitatory glutamatergic neuromuscular arbors through Octbeta2Rs on glutamatergic motor neurons. Octopamine 13-23 Octopamine beta2 receptor Drosophila melanogaster 113-121 21267078-10 2011 The data suggest that one effect of octopamine via AmOA1 in the antennal lobe and mushroom body is to modulate inhibitory neurons. Octopamine 36-46 octopamine receptor Apis mellifera 51-56 19278013-1 2009 The effect of exogenous 20-hydroxyecdysone (20E) and juvenile hormone (JH) on the activities of the tyrosine decarboxylase (TDC), the first enzyme in octopamine (OA) synthesis, has been studied in young females of wild type D. virilis and D. melanogaster under normal and heat stress (38 degrees C) conditions. Octopamine 150-160 Tyrosine decarboxylase 1 Drosophila melanogaster 124-127 22073124-3 2011 Subtype TAAR1, the best characterized TAAR so far, is promiscuous for a wide set of ligands and is activated by trace amines tyramine (TYR), phenylethylamine (PEA), octopamine (OA), but also by thyronamines, dopamine, and psycho-active drugs. Octopamine 165-175 trace amine associated receptor 1 Homo sapiens 8-13 22073124-3 2011 Subtype TAAR1, the best characterized TAAR so far, is promiscuous for a wide set of ligands and is activated by trace amines tyramine (TYR), phenylethylamine (PEA), octopamine (OA), but also by thyronamines, dopamine, and psycho-active drugs. Octopamine 177-179 trace amine associated receptor 1 Homo sapiens 8-13 20534837-8 2010 In contrast, octopamine appears to inhibit 5-HT stimulation by activating Galpha(o) signaling in the ASHs that, in turn, inhibits both Galpha(s) and Galpha(q) signaling and the release of nlp-3-encoded peptides. Octopamine 13-23 Neuropeptide-Like Protein Caenorhabditis elegans 188-193 20302871-3 2010 Using an expression vector and transient transfections of Spi-OAR into HEK 293 cells, we observed an increase of cAMP upon addition of octopamine and, to a lesser extent, of tyramine, but not after addition of dopamine, serotonin, or histamine. Octopamine 135-145 chromogranin A Homo sapiens 58-61 20228998-8 2010 Using a mutation in the tyramine beta hydroxylase (TbetaH[M18]) and blocking of evoked synaptic transmission in the octopamine (and tyramine) neurons labeled with a tyramine decarboxylase-2 (TDC2) gene regulatory elements we found that reinforcement of place memories is independent of normal octopamine signaling. Octopamine 116-126 Tyrosine decarboxylase 2 Drosophila melanogaster 165-189 20188656-3 2010 Application of dopamine, the main neuromodulator involved in aversive learning, resulted in PKA activation specifically in the vertical lobe, whereas octopamine, involved in appetitive learning, stimulated PKA in all MB lobes. Octopamine 150-160 Protein kinase, cAMP-dependent, catalytic subunit 2 Drosophila melanogaster 206-209 20188656-5 2010 Furthermore, costimulation with acetylcholine and either dopamine or octopamine led to a synergistic activation of PKA in the MBs that depends on Rutabaga adenylyl cyclase. Octopamine 69-79 Protein kinase, cAMP-dependent, catalytic subunit 2 Drosophila melanogaster 115-118 19570037-5 2009 Comparison of the PNMT-noradrenaline complex with the previously determined PNMT-p-octopamine complex demonstrates that these two substrates form almost equivalent interactions with the enzyme and show that p-octopamine is a valid model substrate for PNMT. Octopamine 81-93 phenylethanolamine N-methyltransferase Homo sapiens 76-80 19570037-5 2009 Comparison of the PNMT-noradrenaline complex with the previously determined PNMT-p-octopamine complex demonstrates that these two substrates form almost equivalent interactions with the enzyme and show that p-octopamine is a valid model substrate for PNMT. Octopamine 81-93 phenylethanolamine N-methyltransferase Homo sapiens 76-80 17703313-2 2008 L: -dihydroxyphenylalanine and octopamine feeding increases ecdysone 20-monooxygenase activity by a factor of 1.6 and 1.7, respectively. Octopamine 31-41 shade Drosophila melanogaster 60-85 18823548-7 2008 We found that activation of Ap oa1 by octopamine enhanced glutamatergic synaptic transmission in the ACC by increasing presynaptic glutamate release in vitro. Octopamine 38-48 apolipoprotein A-I Mus musculus 28-34 18799671-0 2008 Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. Octopamine 0-10 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 49-65 18799671-6 2008 Because protein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophila sleep, we investigated its role in the effects of octopamine on sleep. Octopamine 55-65 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 8-24 18799671-6 2008 Because protein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophila sleep, we investigated its role in the effects of octopamine on sleep. Octopamine 55-65 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 26-29 18799671-6 2008 Because protein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophila sleep, we investigated its role in the effects of octopamine on sleep. Octopamine 163-173 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 8-24 18799671-6 2008 Because protein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophila sleep, we investigated its role in the effects of octopamine on sleep. Octopamine 163-173 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 26-29 18443837-5 2008 In a mutant with little octopamine (Tbetah), jump muscle performance is reduced by 28%. Octopamine 24-34 Tyramine beta hydroxylase Drosophila melanogaster 36-42 19033154-2 2009 To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. Octopamine 204-214 Vesicular monoamine transporter Drosophila melanogaster 80-122 19033154-2 2009 To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. Octopamine 204-214 Vesicular monoamine transporter Drosophila melanogaster 124-129 19262750-2 2009 We have previously shown that OAMB, a Drosophila G-protein-coupled receptor for octopamine (the insect counterpart of mammalian norepinephrine), is required for ovulation induced upon mating. Octopamine 80-90 Octopamine receptor in mushroom bodies Drosophila melanogaster 30-34 17900709-1 2007 Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons. Octopamine 31-41 trace amine associated receptor 1 Homo sapiens 109-142 17900709-1 2007 Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons. Octopamine 31-41 trace amine associated receptor 1 Homo sapiens 144-149 17933333-0 2007 Effect of octopamine on ecdysone-20 monooxygenase activity in Drosophila. Octopamine 10-20 shade Drosophila melanogaster 24-49 17638385-8 2007 However, flies that contain no measurable neural octopamine and an excess of tyramine due to a null mutation in the tyramine beta-hydroxylase gene (TbetaH(nM18)) exhibit normal locomotor activity and cocaine responses in spite of showing female sterility due to loss of octopamine. Octopamine 270-280 Tyramine beta hydroxylase Drosophila melanogaster 116-141 17638385-8 2007 However, flies that contain no measurable neural octopamine and an excess of tyramine due to a null mutation in the tyramine beta-hydroxylase gene (TbetaH(nM18)) exhibit normal locomotor activity and cocaine responses in spite of showing female sterility due to loss of octopamine. Octopamine 270-280 Tyramine beta hydroxylase Drosophila melanogaster 148-154 17928454-6 2007 Octopamine is not the natural signal for flight initiation because flies lacking octopamine [tyramine-beta-hydroxylase (TbetaH) null mutants] can fly. Octopamine 81-91 Tyramine beta hydroxylase Drosophila melanogaster 93-118 17928454-11 2007 Conversely, ablating all neurons containing octopamine or tyramine phenocopies TbetaH mutants. Octopamine 44-54 Tyramine beta hydroxylase Drosophila melanogaster 79-85 16740144-7 2007 When learning mutant t beta h flies, which are deficient in octopamine, were challenged, they exhibited poor performance, validating the utility of this assay. Octopamine 60-70 Tyramine beta hydroxylase Drosophila melanogaster 21-29 17360588-6 2007 A single Fru(M)-positive OCT neuron sends extensive bilateral arborizations to the suboesophageal ganglion, the lateral accessory lobe, and possibly the posterior antennal lobe, suggesting a mechanism for integrating multiple sensory modalities. Octopamine 25-28 fruitless Drosophila melanogaster 9-12 17360588-7 2007 Furthermore, eliminating the expression of Fru(M) by transformer expression in OCT/tyramine neurons changes the aggression versus courtship response behavior. Octopamine 79-82 fruitless Drosophila melanogaster 43-46 15849736-7 2005 Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor. Octopamine 74-84 Vesicular monoamine transporter Drosophila melanogaster 46-53 16363801-5 2005 The mode of binding of cis-(1R,2S)-AT supports the notion that this substrate is a conformationally restrained analogue of flexible PNMT substrates, in that it forms interactions with the enzyme similar to those observed for p-octopamine. Octopamine 225-237 phenylethanolamine N-methyltransferase Homo sapiens 132-136 16363801-9 2005 These results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present. Octopamine 162-174 phenylethanolamine N-methyltransferase Homo sapiens 27-31 16768790-10 2006 They all express tyrosine decarboxylase (required for tyramine and octopamine synthesis) and Drosophila vesicular monoamine transporter (DVMAT). Octopamine 67-77 Tyrosine decarboxylase 1 Drosophila melanogaster 17-39 16452672-3 2006 We have shown previously that Tbetah(nM18) mutants, with altered levels of octopamine and tyramine, have a locomotion deficit. Octopamine 75-85 Tyramine beta hydroxylase Drosophila melanogaster 30-36 15849736-7 2005 Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor. Octopamine 74-84 Vesicular monoamine transporter Drosophila melanogaster 47-51 15849736-10 2005 Our data suggest that DVMAT-A functions as a vesicular transporter for DA, 5HT, and octopamine in vivo, and will provide a powerful invertebrate model for the study of transporter trafficking and regulation. Octopamine 84-94 Vesicular monoamine transporter Drosophila melanogaster 22-29 15986384-10 2005 The toxicity of tested chemicals against wild type and octopamine mutant (iav) fly strains suggested that an octopamine receptor mediates the toxicity of cinnamic alcohol, eugenol, trans-antehole, and 2-phenethyl propionate against fruit flies. Octopamine 55-65 Octopamine receptor in mushroom bodies Drosophila melanogaster 109-128 15729684-7 2005 The tyramine-beta-hydroxylase mutant (TbetaH) with increased tyramine and depleted octopamine levels displays normal ethanol sensitivity, a startle repression, and hyperactivates more in response to ethanol. Octopamine 83-93 Tyramine beta hydroxylase Drosophila melanogaster 4-29 15953361-6 2005 Other physiologically relevant biogenic amines, such as octopamine and dopamine, inhibit [(3)H]tyramine binding with much lower affinity (K(i)s of 1.55 +/- 0.5 and 1.78 +/- 0.6 microM, respectively), supporting the identification of TYRA-2 as a tyramine receptor. Octopamine 56-66 Tyramine receptor tyra-2 Caenorhabditis elegans 233-239 15953361-6 2005 Other physiologically relevant biogenic amines, such as octopamine and dopamine, inhibit [(3)H]tyramine binding with much lower affinity (K(i)s of 1.55 +/- 0.5 and 1.78 +/- 0.6 microM, respectively), supporting the identification of TYRA-2 as a tyramine receptor. Octopamine 56-66 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 245-262 15729684-7 2005 The tyramine-beta-hydroxylase mutant (TbetaH) with increased tyramine and depleted octopamine levels displays normal ethanol sensitivity, a startle repression, and hyperactivates more in response to ethanol. Octopamine 83-93 Tyramine beta hydroxylase Drosophila melanogaster 38-44 15816867-7 2005 The second gene (Dmoa2) codes for a receptor that specifically activates adenylate cyclase and causes a rise of intracellular cAMP with an EC(50) of approximately 3 x 10(-8) m octopamine. Octopamine 176-186 Octopamine beta1 receptor Drosophila melanogaster 17-22 15848803-1 2005 Octopamine biosynthesis requires tyrosine decarboxylase to convert tyrosine into tyramine and tyramine beta-hydroxylase to convert tyramine into octopamine. Octopamine 0-10 Tyrosine decarboxylase Caenorhabditis elegans 33-55 15848803-1 2005 Octopamine biosynthesis requires tyrosine decarboxylase to convert tyrosine into tyramine and tyramine beta-hydroxylase to convert tyramine into octopamine. Octopamine 0-10 DOMON domain-containing protein;Tyramine beta-hydroxylase Caenorhabditis elegans 94-119 15691831-0 2005 Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility. Octopamine 116-126 Tyrosine decarboxylase 1 Drosophila melanogaster 47-69 15691831-3 2005 To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2. Octopamine 60-70 Tyrosine decarboxylase 1 Drosophila melanogaster 91-94 15691831-3 2005 To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2. Octopamine 60-70 Tyrosine decarboxylase 1 Drosophila melanogaster 131-136 15691831-3 2005 To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2. Octopamine 60-70 Tyrosine decarboxylase 2 Drosophila melanogaster 141-146 15691831-5 2005 Flies with a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention. Octopamine 56-66 Tyrosine decarboxylase 2 Drosophila melanogaster 25-30 15691831-9 2005 The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities. Octopamine 138-148 Tyrosine decarboxylase 2 Drosophila melanogaster 35-40 15848803-1 2005 Octopamine biosynthesis requires tyrosine decarboxylase to convert tyrosine into tyramine and tyramine beta-hydroxylase to convert tyramine into octopamine. Octopamine 145-155 DOMON domain-containing protein;Tyramine beta-hydroxylase Caenorhabditis elegans 94-119 15270233-4 2004 The B2 and B3 neurons are inhibited by octopamine, and the response is not affected by IBMX. Octopamine 39-49 immunoglobulin kappa variable 5-2 Homo sapiens 4-13 15569254-5 2004 In contrast, SER-2A exhibits a significantly lower affinity than SER-2 for other physiologically relevant biogenic amines, including octopamine. Octopamine 133-143 G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 Caenorhabditis elegans 13-18 15569254-11 2004 These results suggest that C. elegans contains tyramine receptors, that individual SER-2 isoforms may differ significantly in their sensitivity to other physiologically relevant biogenic amines, such as octopamine (OA), and that tyraminergic signaling may be important in the regulation of key processes in nematodes. Octopamine 203-213 G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 Caenorhabditis elegans 83-88 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Octopamine 32-42 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 89-92 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Octopamine 32-42 glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog Xenopus laevis 93-97 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Octopamine 32-42 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 102-105 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Octopamine 32-42 glutamate receptor ionotropic, NMDA 2B Xenopus laevis 106-110 14978721-5 2004 We found that Tbetah(nM18) mutants, with elevated tyramine levels and reduced octopamine levels, had a severe locomotion phenotype. Octopamine 78-88 Tyramine beta hydroxylase Drosophila melanogaster 14-20 14978721-7 2004 The locomotion phenotype was partially rescued by feeding Tbetah(nM18) larvae octopamine, an effect that could be nullified with simultaneous feeding of tyramine. Octopamine 78-88 Tyramine beta hydroxylase Drosophila melanogaster 58-64 14623230-3 2003 The Tbetah gene has been previously cloned from Drosophila melanogaster, and null mutations have been generated resulting in octopamine-less flies that show profound female sterility. Octopamine 125-135 Tyramine beta hydroxylase Drosophila melanogaster 4-10 14623230-6 2003 Fertility of the mutant females is also restored when TBH is expressed, via the GAL4-UAS system, in cells of the CNS abdominal ganglion that express TBH and produce octopamine. Octopamine 165-175 Tyramine beta hydroxylase Drosophila melanogaster 54-57 12900412-9 2003 The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline. Octopamine 179-189 N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT1-3 Solanum lycopersicum 10-19 12900412-9 2003 The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline. Octopamine 179-189 N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT7-1 Solanum lycopersicum 21-30 12900412-9 2003 The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline. Octopamine 179-189 N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT7-8 Solanum lycopersicum 36-45 11853123-4 2002 Both in vitro and ex vivo assays were performed on rat brain homogenates, and IC50 and ID50 were calculated by a fluorometric method with octopamine as selective MAO-A substrate. Octopamine 138-148 monoamine oxidase A Rattus norvegicus 162-167 12354282-6 2002 COS-7 cells expressing SER-2 bind [3H]LSD in the low nM range and exhibit Kis for tyramine, octopamine and serotonin of 0.07, 2, and 13.7 micro m, respectively. Octopamine 92-102 jagged canonical Notch ligand 2 Homo sapiens 23-28 11919655-0 2002 Is Na(+) required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter? Octopamine 74-84 solute carrier family 6 member 3 Homo sapiens 98-118 15000448-2 2003 We have already reported that octopamine is able to activate in vitro lipolysis in rat adipocytes via beta3-adrenergic receptor activation, while it activates glucose uptake in human fat cells via its oxidation by amine oxidases. Octopamine 30-40 adrenoceptor beta 3 Rattus norvegicus 102-127 11561068-0 2001 Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. Octopamine 15-25 adrenoceptor beta 3 Homo sapiens 79-97 11561068-5 2001 The lipolytic effect and the counter-regulation of insulin action on glucose transport provoked by 0.1 to 1 mM octopamine or by 1 microM beta3-AR agonists found in control animals disappeared in adipocytes from beta3-AR-deficient mice. Octopamine 111-121 adrenergic receptor, beta 3 Mus musculus 211-219 11561068-6 2001 This revealed an insulin-like effect of octopamine on glucose uptake, which was dependent on its oxidation by MAO or SSAO, as was the case for tyramine and benzylamine, devoid of beta3-adrenergic agonism. Octopamine 40-50 amine oxidase copper containing 2 Homo sapiens 117-121 11561068-8 2001 These findings indicate that, besides its lipolytic activity, octopamine exerts, at millimolar dose, dual effect on glucose transport in adipocytes: counteracting insulin action via beta3-AR activation and stimulating basal transport via its oxidation by MAO or SSAO. Octopamine 62-72 adrenoceptor beta 3 Homo sapiens 182-190 11561068-8 2001 These findings indicate that, besides its lipolytic activity, octopamine exerts, at millimolar dose, dual effect on glucose transport in adipocytes: counteracting insulin action via beta3-AR activation and stimulating basal transport via its oxidation by MAO or SSAO. Octopamine 62-72 amine oxidase copper containing 2 Homo sapiens 262-266 11125028-6 2001 The substrate selectivity of dDAT parallels that of the mammalian DATs in that dopamine and tyramine are the preferred substrates, whereas octopamine is transported less efficiently, and serotonin not at all. Octopamine 139-149 Dopamine transporter Drosophila melanogaster 29-33 11196449-2 2000 Noradrenaline, octopamine and Compound A inhibited the type I DOC induced difference spectrum of P450c11 and elicited a type II difference spectrum when added alone. Octopamine 15-25 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 97-104 10433494-4 1999 The Ser-->Ala200 or the Ser-->Ala204 mutant forms of the alpha2A-adrenoceptor, when expressed in cells in the absence of pertussis toxin pretreatment, are two orders of magnitude more sensitive to inhibition of cyclic AMP production by (+/-)-para-octopamine and (+/-)-meta-octopamine, respectively, than cells expressing the wild-type receptor. Octopamine 242-263 adrenoceptor alpha 2A Homo sapiens 63-83 10737611-0 2000 Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter. Octopamine 65-75 solute carrier family 6 member 3 Homo sapiens 103-123 11790328-7 2000 Although being around one hundred-fold less potent that noradrenaline, octopamine was slightly more potent in these hibernators known for their high sensitivity to beta(3)-AR agonists than in rat and chiefly more active than in human adipocytes known for their limited responses to beta(3)-AR agonists. Octopamine 71-81 adrenoceptor beta 3 Homo sapiens 164-174 11790328-7 2000 Although being around one hundred-fold less potent that noradrenaline, octopamine was slightly more potent in these hibernators known for their high sensitivity to beta(3)-AR agonists than in rat and chiefly more active than in human adipocytes known for their limited responses to beta(3)-AR agonists. Octopamine 71-81 adrenoceptor beta 3 Homo sapiens 282-292 11790328-8 2000 Second, octopamine reduced insulin-dependent glucose transport in rat fat cells, a response also observed with noradrenaline and selective beta(3)-AR agonists but not with beta(1)-or beta(2)-agonists. Octopamine 8-18 adrenoceptor beta 3 Homo sapiens 139-149 11790328-15 2000 Thus, octopamine could be considered as an endogenous selective beta(3)-AR agonist. Octopamine 6-16 adrenoceptor beta 3 Homo sapiens 64-74 10603275-0 1999 Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani. Octopamine 10-20 juvenile hormone esterase 1 Bombyx mori 40-65 10433494-10 1999 The results emphasise the importance of the Ser200 and Ser204 residues of the alpha2A-adrenoceptor in exerting an inhibitory influence on the ability of (+/-)-para-octopamine and (+/-)-meta-octopamine respectively, to induce a receptor-agonist conformation capable of inhibiting forskolin-stimulation of cyclic AMP levels. Octopamine 153-174 adrenoceptor alpha 2A Homo sapiens 78-98 9313925-0 1997 Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. Octopamine 44-54 adrenoceptor alpha 2A Homo sapiens 74-95 9874092-4 1998 SSAO metabolizes benzylamine and methylamine in all tissues tested and possibly dopamine and octopamine as well, as shown in competition studies. Octopamine 93-103 amine oxidase copper containing 2 Homo sapiens 0-4 9705469-6 1998 Octopamine enhances GCl,H, mainly by increasing Gmax. Octopamine 0-10 germ cell-less 2, spermatogenesis associated Homo sapiens 20-23 9570796-4 1998 One new receptor, octopamine receptor in mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell lines expressing OAMB showed increased cAMP and intracellular Ca2+ levels after octopamine application. Octopamine 18-28 Octopamine receptor in mushroom bodies Drosophila melanogaster 58-62 9570796-4 1998 One new receptor, octopamine receptor in mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell lines expressing OAMB showed increased cAMP and intracellular Ca2+ levels after octopamine application. Octopamine 18-28 Octopamine receptor in mushroom bodies Drosophila melanogaster 157-161 9579229-2 1998 It has been suggested that the ratio between branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) (BCAA/ AAA ratio) may determine in part the brain concentration of the AAAs, since the BCAAs compete with the AAAs for entry across the blood-brain barrier, leading to the accumulation of false neurotransmitters such as octopamine and phenylethanolamine, which are able to stimulate GH secretion (via alpha 2-adrenergic stimulation). Octopamine 332-342 AT-rich interaction domain 4B Homo sapiens 73-77 9579229-2 1998 It has been suggested that the ratio between branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) (BCAA/ AAA ratio) may determine in part the brain concentration of the AAAs, since the BCAAs compete with the AAAs for entry across the blood-brain barrier, leading to the accumulation of false neurotransmitters such as octopamine and phenylethanolamine, which are able to stimulate GH secretion (via alpha 2-adrenergic stimulation). Octopamine 332-342 AAA1 Homo sapiens 106-109 10344530-11 1999 Octopamine had other properties in common with beta3-AR agonists: stimulation of oxygen consumption in rat brown fat cells and very low affinity in displacing [3H]CGP 12,177 binding to [beta1- or beta2-ARs in dog and rat adipocyte membranes. Octopamine 0-10 adrenoceptor beta 3 Homo sapiens 47-55 10344530-11 1999 Octopamine had other properties in common with beta3-AR agonists: stimulation of oxygen consumption in rat brown fat cells and very low affinity in displacing [3H]CGP 12,177 binding to [beta1- or beta2-ARs in dog and rat adipocyte membranes. Octopamine 0-10 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 186-192 10344530-12 1999 In Chinese hamster ovary (CHO) cells expressing human beta3-ARs, octopamine inhibited [125I]ICYP binding with only twofold less affinity than noradrenaline while it exhibited an affinity around 200-fold lower than noradrenaline in CHO cells expressing human beta1- or beta2-ARs. Octopamine 65-75 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 258-264 9313925-8 1997 The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers. Octopamine 18-28 adrenoceptor alpha 2A Homo sapiens 73-94 9313925-8 1997 The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers. Octopamine 248-258 adrenoceptor alpha 2A Homo sapiens 73-94 9313925-17 1997 Since octopamine and synephrine occur naturally in, and are co-released with catecholamines from, mammalian tissues, the results of the present study suggest that the human cloned alpha 2A-adrenoceptor can be coupled selectively by different endogenous agonists to G-protein pathways mediating the regulation of adenylyl cyclase activity. Octopamine 6-16 adrenoceptor alpha 2A Homo sapiens 180-201 8496068-8 1993 This is attributed to the deficiency of octopamine in iav mutants because low octopamine levels may be unable to out-compete the toxic effect of p-Cresol. Octopamine 40-50 inactive Drosophila melanogaster 54-57 9120070-8 1997 Dopamine-N-acetyltransferase, which is on the catabolic route to dopamine, serotonin, and octopamine, has no effect. Octopamine 90-100 Arylalkylamine N-acetyltransferase 1 Drosophila melanogaster 0-28 8695909-1 1996 Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA. Octopamine 76-86 monoamine oxidase B Homo sapiens 135-151 8695909-1 1996 Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA. Octopamine 76-86 monoamine oxidase A Homo sapiens 201-205 8199852-1 1994 Immunocytochemical techniques are employed to reveal colocalization of octopamine with FMRFamide related peptide in the locust ventral nervous system. Octopamine 71-81 neuropeptide VF precursor Homo sapiens 87-112 8199852-5 1994 With respect to locust ventral ganglia, this investigation shows that colocalization of octopamine with an FMRFamide related peptide is restricted to a single DUM cell occurring in each abdominal ganglion 2-7, which most likely corresponds to segmental homologues of DUM heart-1. Octopamine 88-98 neuropeptide VF precursor Homo sapiens 107-132 8371829-1 1993 Octopamine receptor subclasses were first proposed to explain differences in the pharmacological profiles of a range of physiological responses to octopamine obtained in the extensor-tibiae neuromuscular preparation of the locust. Octopamine 147-157 Octopamine-Tyramine receptor Drosophila melanogaster 0-19 9045634-8 1997 However, electrophysiological experiments indicate that octopamine is able to activate a voltage-independent Cl- current in HEK293 cells stably expressing Lym oa2. Octopamine 56-66 OA2 Homo sapiens 159-162 9014328-4 1996 In stimulation experiments its responded to octopamine leading to an inhibition of adenylate cyclase activity in a dose-dependent manner. Octopamine 44-54 adenylate cyclase Bombyx mori 83-100 8656284-2 1996 Here we report the molecular cloning of the Drosophila melanogaster gene, which encodes tyramine beta-hydroxylase (TBH), the enzyme that catalyzes the last step in octopamine biosynthesis. Octopamine 164-174 Tyramine beta hydroxylase Drosophila melanogaster 88-113 8656284-2 1996 Here we report the molecular cloning of the Drosophila melanogaster gene, which encodes tyramine beta-hydroxylase (TBH), the enzyme that catalyzes the last step in octopamine biosynthesis. Octopamine 164-174 Tyramine beta hydroxylase Drosophila melanogaster 115-118 8656284-4 1996 We generated a polyclonal antibody against the protein product of T beta h gene, and we demonstrate that the TBH expression pattern is remarkably similar to the previously described octopamine immunoreactivity in Drosophila. Octopamine 182-192 Tyramine beta hydroxylase Drosophila melanogaster 66-74 8656284-5 1996 We further report the creation of null mutations at the T beta h locus, which result in complete absence of TBH protein and blockage of the octopamine biosynthesis. Octopamine 140-150 Tyramine beta hydroxylase Drosophila melanogaster 56-64 8656284-6 1996 T beta h-null flies are octopamine-less but survive to adulthood. Octopamine 24-34 Tyramine beta hydroxylase Drosophila melanogaster 0-8 8532118-5 1995 MAO-A and MAO-B activities were measured using octopamine and benzylamine respectively. Octopamine 47-57 monoamine oxidase B Rattus norvegicus 10-15 8496068-1 1993 Flies carrying the inactive (iav) mutation exhibit low locomotor activity and poor mating success, both of which are associated with a deficiency in the putative neurotransmitter, octopamine. Octopamine 180-190 inactive Drosophila melanogaster 29-32 8496068-6 1993 Flies carrying the iav mutation are highly susceptible to the octopamine analogue p-Cresol. Octopamine 62-72 inactive Drosophila melanogaster 19-22 8496068-8 1993 This is attributed to the deficiency of octopamine in iav mutants because low octopamine levels may be unable to out-compete the toxic effect of p-Cresol. Octopamine 78-88 inactive Drosophila melanogaster 54-57 2509446-3 1989 The preincubation of platelet MAO-B with purified MAO-A from mitochondrial membranes of human placenta resulted in appearance of excess octopamine activity. Octopamine 136-146 monoamine oxidase B Homo sapiens 30-35 33796867-4 2021 This olfactory circuit signals the gut to suppress DR-mediated longevity via octopamine, the mammalian homolog of norepinephrine, by regulating the energy sensor AMPK through a Gq-PLCbeta-CaMKK-dependent mechanism. Octopamine 77-87 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 162-166 33796867-4 2021 This olfactory circuit signals the gut to suppress DR-mediated longevity via octopamine, the mammalian homolog of norepinephrine, by regulating the energy sensor AMPK through a Gq-PLCbeta-CaMKK-dependent mechanism. Octopamine 77-87 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 188-193 34068603-3 2021 These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone). Octopamine 215-225 Adipokinetic hormone Drosophila melanogaster 40-43 34068603-3 2021 These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone). Octopamine 215-225 Corazonin Drosophila melanogaster 49-58 34068603-3 2021 These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone). Octopamine 215-225 Corazonin Drosophila melanogaster 60-63 35411674-2 2022 In Drosophila, four types of octopamine receptors have been identified: Oamb, Oct/TyrR, OctbetaR and Octalpha2R. Octopamine 29-39 Octopamine receptor in mushroom bodies Drosophila melanogaster 72-76 35411674-2 2022 In Drosophila, four types of octopamine receptors have been identified: Oamb, Oct/TyrR, OctbetaR and Octalpha2R. Octopamine 29-39 Octopamine-Tyramine receptor Drosophila melanogaster 78-86 1677640-2 1991 Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons. Octopamine 143-153 dopamine beta-hydroxylase Homo sapiens 0-25 1677640-2 1991 Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons. Octopamine 143-153 dopamine beta-hydroxylase Homo sapiens 27-30 35623862-17 2022 However, it seems that aerobic exercise with octopamine supplementation improves heart tissue function by inhibiting the expression of caspase 3 and pro-caspase 3, leading to a significantly decreased apoptosis in cardiomyocytes of DFO-treated models. Octopamine 45-55 caspase 3 Rattus norvegicus 135-144 2509446-3 1989 The preincubation of platelet MAO-B with purified MAO-A from mitochondrial membranes of human placenta resulted in appearance of excess octopamine activity. Octopamine 136-146 monoamine oxidase A Homo sapiens 50-55 2854205-9 1988 These results suggest that octopamine acts on intestinal dopamine D-1 receptor sites to produce relaxation of rabbit jejunum through an increase of cAMP. Octopamine 27-37 D(1A) dopamine receptor Oryctolagus cuniculus 57-78 2719723-12 1989 It is possible that the activity of SSAO is controlled by octopamine released from sympathetic nerve endings or 5-HT released from platelets. Octopamine 58-68 amine oxidase, copper containing 3 Rattus norvegicus 36-40 2500604-6 1989 When vesicular uptake and MAO were intact, unsubstituted octopamines were only 1.5 to 2.2 times less potent than the corresponding tyramines. Octopamine 57-68 monoamine oxidase A Rattus norvegicus 26-29 3106018-6 1987 On the other hand, octopamine, which is formed from tyramine, also inhibited high PRL values found after stress, though the effective dose was higher than that of tyramine. Octopamine 19-29 prolactin Rattus norvegicus 82-85 2907098-0 1988 Pre- and postsynaptic effects of p-tyramine and p-octopamine in the prostatic portion of the rat vas deferens. Octopamine 48-60 arginine vasopressin Rattus norvegicus 97-100 2907098-1 1988 The effect of p-tyramine and p-octopamine on the twitch responses of the prostatic portion of the rat vas deferens to electrical stimulation (0.025 Hz) were compared with the effects of noradrenaline. Octopamine 29-41 arginine vasopressin Rattus norvegicus 102-105 2907098-3 1988 When MAO activity was inhibited by pargyline (10 mumol/l), p-tyramine and p-octopamine had mixed excitatory-inhibitory effects on the twitches, while noradrenaline had mostly excitatory effects along the whole range of concentrations assayed (0.158-15.8 mumol/l). Octopamine 74-86 monoamine oxidase A Rattus norvegicus 5-8 2443616-2 1987 Tissue levels of cAMP, but not cGMP, were significantly increased in isolated cardiac ganglia and cardiac muscle following 10 min exposure to 10(-5) M OCT or 10(-5) M DA. Octopamine 151-154 cathelicidin antimicrobial peptide Homo sapiens 17-21 2443616-3 1987 In both tissues, OCT elicited larger increases in cAMP than did DA. Octopamine 17-20 cathelicidin antimicrobial peptide Homo sapiens 50-54 3584135-4 1987 The rate of octopamine synthesis from tyramine displayed a Michaelis-Menten relationship with respect to ascorbate concentration and an apparent Km of dopamine beta-hydroxylase for ascorbate of 15.0 +/- 2.0 mM was determined. Octopamine 12-22 dopamine beta-hydroxylase Bos taurus 151-176 3106018-9 1987 It does not displace [3H]spiperone binding from anterior pituitary membranes, and octopamine which lowers PRL release itself, cannot account for the effect of tyramine. Octopamine 82-92 prolactin Rattus norvegicus 106-109 3097015-3 1986 Dopamine beta-hydroxylase activity was assessed by measuring the rate of conversion of tyramine to octopamine. Octopamine 99-109 dopamine beta-hydroxylase Homo sapiens 0-25 3785579-7 1986 Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine. Octopamine 40-50 monoamine oxidase A Rattus norvegicus 77-94 2435897-5 1986 Methionine enkephalin ([Met]-enkephalin) blocked the actions of all the above peptides as well as the effects of DL-octopamine and carbachol. Octopamine 113-126 proopiomelanocortin Homo sapiens 24-39 3785579-7 1986 Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine. Octopamine 40-50 monoamine oxidase A Rattus norvegicus 96-99 6093943-0 1984 Effect of intracerebroventricularly administered octopamines and synephrines on angiotensin II-induced water intake in rats. Octopamine 49-60 angiotensinogen Rattus norvegicus 80-94 3921667-5 1985 m-Octopamine is present in concentrations equal to those of p-octopamine in heart, spleen, and liver and in concentrations from 30 to 60% of p-octopamine in adrenals, vas deferens, brain, kidney, large intestine, bladder, and lungs. Octopamine 1-12 arginine vasopressin Rattus norvegicus 167-170 6093943-2 1984 The objective of this investigation was to determine whether the isomers of both octapamine and synephrine could inhibit angiotensin II-induced dipsogenesis in the rat. Octopamine 81-91 angiotensinogen Rattus norvegicus 121-135 6125331-5 1982 The administration of pargyline, a MAO inhibitor, which increased brain octopamine, resulted in a reduction of systolic blood pressure; and this decrease was greater after administration of octopamine precursors and PEA. Octopamine 72-82 monoamine oxidase A Rattus norvegicus 35-38 226908-8 1979 Probenecid loading test revealed that 5-HIAA was normal, HVA high, and large amount of octopamine was detected in CSF. Octopamine 87-97 colony stimulating factor 2 Homo sapiens 114-117 6777088-2 1980 The assay is based on the conversion of NMN or OCT to radiolabeled metanephrine (MN) or synephrine (SYN) by phenylethanolamine-N-methyl transferase (PNMT), using tritium-labeled S-adenosyl-methionine [3H]SAM as methyl donor. Octopamine 47-50 phenylethanolamine N-methyltransferase Homo sapiens 108-147 6777088-2 1980 The assay is based on the conversion of NMN or OCT to radiolabeled metanephrine (MN) or synephrine (SYN) by phenylethanolamine-N-methyl transferase (PNMT), using tritium-labeled S-adenosyl-methionine [3H]SAM as methyl donor. Octopamine 47-50 phenylethanolamine N-methyltransferase Homo sapiens 149-153 33410264-0 2021 Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octbeta2R cascade. Octopamine 39-49 Octopamine beta2 receptor Drosophila melanogaster 93-102 19604876-1 1976 Normal carotid bodies excised from cats showed DBH values of 5.04 + or - 0.53 nmol [(3)H]octopamine formed/h/100 mg tissue (x + or - S.E. Octopamine 89-99 dopamine beta-hydroxylase Felis catus 47-50 799466-2 1976 In mammals, octopamine is formed from tyramine through beta-hydroxylation by DBH in the sympathetic nerves, and it is partially stored in nerve endings with a subcellular distribution similar to that of NE. Octopamine 12-22 dopamine beta-hydroxylase Homo sapiens 77-80 242128-1 1975 A method for the estimation of dopamine beta-hydroxylase activity in human serum is described, based on a thin layer chromatographic separation of the substrate ([14C]tyramine) from the reaction product ([14C]octopamine). Octopamine 209-219 dopamine beta-hydroxylase Homo sapiens 31-56 33538092-5 2021 Manipulation of the genes tyramine beta-hydroxylase and tyrosine hydroxylase, which respectively synthesize octopamine and dopamine from tyramine and tyrosine, had no discernable effect on alcohol sedation, suggesting that Tdc2 affects alcohol sedation by regulating tyramine production. Octopamine 108-118 Tyramine beta hydroxylase Drosophila melanogaster 26-51 637594-4 1978 Plasma and CSF octopamine and phenylethanolamine and CSF 5-HIAA increased markedly as clinical features in the dogs" behavior, characteristic of hepatic encephalopathy occurred, including hypersalivation, ataxia, flapping tremor, somnolence and finally coma. Octopamine 15-25 colony stimulating factor 2 Canis lupus familiaris 11-14 831826-8 1977 The phenolic amines, octopamine, synephrine, serotonin and tyramine, stimulated tRNA methylation slightly while inhibiting histone methylation by both liver and brain extracts and these effects showed no age dependency. Octopamine 21-31 Trng Rattus norvegicus 80-84 831826-8 1977 The phenolic amines, octopamine, synephrine, serotonin and tyramine, stimulated tRNA methylation slightly while inhibiting histone methylation by both liver and brain extracts and these effects showed no age dependency. Octopamine 21-31 H2B clustered histone 1 Rattus norvegicus 123-130 33910059-6 2021 Using a Drosophila model of tauopathy, we conducted a candidate modifier screen targeting tyramine beta hydroxylase (tbetah), the enzyme that controls the production of octopamine in the fly, to determine if levels of this enzyme modulate Tau-induced degeneration in the fly eye. Octopamine 169-179 Tyramine beta hydroxylase Drosophila melanogaster 117-123 33909537-0 2021 She"s got nerve: roles of octopamine in insect female reproduction. Octopamine 26-36 Glutamate oxaloacetate transaminase 2 Drosophila melanogaster 6-9 33915977-3 2021 TAR1, the prominent player in this system, was initially classified as an octopamine receptor which can also be activated by tyramine, while it later appeared to be a true tyramine receptor. Octopamine 74-84 trace amine associated receptor 1 Homo sapiens 0-4 33410264-6 2021 We demonstrate that stuxnet positively regulates Octbeta2R through repression of Polycomb in the ellipsoid body of the adult fly brain and that Octbeta2R is one of the major receptors mediating octopamine function in sleep homeostasis. Octopamine 194-204 Octopamine beta2 receptor Drosophila melanogaster 144-153 33410264-7 2021 In response to octopamine, Octbeta2R transcription is inhibited as a result of stuxnet downregulation. Octopamine 15-25 Octopamine beta2 receptor Drosophila melanogaster 27-36 33410264-9 2021 This study demonstrates a Stuxnet-Polycomb-Octbeta2R-mediated epigenetic regulatory mechanism for octopamine reception, thus providing an example of epigenetic regulation of sleep homeostasis. Octopamine 98-108 Polycomb Drosophila melanogaster 34-42 33410264-9 2021 This study demonstrates a Stuxnet-Polycomb-Octbeta2R-mediated epigenetic regulatory mechanism for octopamine reception, thus providing an example of epigenetic regulation of sleep homeostasis. Octopamine 98-108 Octopamine beta2 receptor Drosophila melanogaster 43-52 33077027-6 2020 Octopamine and its receptor Oamb are also required for mating-induced GSC increase via intracellular Ca2+ signaling. Octopamine 0-10 Octopamine receptor in mushroom bodies Drosophila melanogaster 28-32 33077027-7 2020 Moreover, we identified Matrix metalloproteinase-2 as a downstream component of the octopamine-Ca2+ signaling to induce GSC increase. Octopamine 84-94 Matrix metalloproteinase 2 Drosophila melanogaster 24-50 33077117-6 2020 At 20 C the octopamine receptor gene (oa1) was underexpressed in bees that were not exposed to IMD, but overexpressed in individuals exposed to 2.5 ppb IMD. Octopamine 12-22 octopamine receptor Apis mellifera 38-41 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 75-79 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 126-130 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 126-130 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 75-79 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 126-130 32060912-5 2020 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along with a novel genome-edited conditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons to varying degrees. Octopamine 162-172 Tyrosine decarboxylase 2 Drosophila melanogaster 126-130 32277043-4 2020 Here, we report that octopamine activity through the beta adrenergic-like receptor Octbeta1R drives aversive and appetitive learning: Octbeta1R in the mushroom body alphabeta neurons processes aversive learning whereas Octbeta1R in the projection neurons mediates appetitive learning. Octopamine 21-31 Octopamine beta1 receptor Drosophila melanogaster 83-92 32386525-13 2020 Furthermore, we found that octopamine neurons contact Crz neurons in the subesophageal zone (SEZ), transmitting signals for systemic growth. Octopamine 27-37 Corazonin Drosophila melanogaster 54-57 32386525-14 2020 Together, our results suggest that the Crz-PTTH neuronal axis modulates ecdysteroid biosynthesis in response to octopamine, uncovering a regulatory neuroendocrine system in the developmental transition from growth to maturation. Octopamine 112-122 Corazonin Drosophila melanogaster 39-42 32386525-14 2020 Together, our results suggest that the Crz-PTTH neuronal axis modulates ecdysteroid biosynthesis in response to octopamine, uncovering a regulatory neuroendocrine system in the developmental transition from growth to maturation. Octopamine 112-122 Prothoracicotropic hormone Drosophila melanogaster 43-47 32277043-4 2020 Here, we report that octopamine activity through the beta adrenergic-like receptor Octbeta1R drives aversive and appetitive learning: Octbeta1R in the mushroom body alphabeta neurons processes aversive learning whereas Octbeta1R in the projection neurons mediates appetitive learning. Octopamine 21-31 Octopamine beta1 receptor Drosophila melanogaster 134-143 32277043-4 2020 Here, we report that octopamine activity through the beta adrenergic-like receptor Octbeta1R drives aversive and appetitive learning: Octbeta1R in the mushroom body alphabeta neurons processes aversive learning whereas Octbeta1R in the projection neurons mediates appetitive learning. Octopamine 21-31 Octopamine beta1 receptor Drosophila melanogaster 134-143 32277043-8 2020 Consistently, the mushroom body and projection neurons in the octbeta1r brain exhibit blunted responses to octopamine when cAMP levels are monitored through the cAMP sensor. Octopamine 107-117 Octopamine beta1 receptor Drosophila melanogaster 62-71 32277043-15 2020 Here, we demonstrate that the octopamine-Octbeta1R-cAMP pathway processes both aversive and appetitive learning in distinct neural sites of the olfactory circuit. Octopamine 30-40 Octopamine beta1 receptor Drosophila melanogaster 41-50 32277043-16 2020 Furthermore, we show that the octopamine-Octbeta1R and dopamine-dDA1 signals together drive both aversive and appetitive learning whereas the octopamine-Octbeta1R and octopamine-OAMB pathways jointly facilitate appetitive, but not aversive, learning. Octopamine 30-40 Octopamine beta1 receptor Drosophila melanogaster 41-50 32277043-16 2020 Furthermore, we show that the octopamine-Octbeta1R and dopamine-dDA1 signals together drive both aversive and appetitive learning whereas the octopamine-Octbeta1R and octopamine-OAMB pathways jointly facilitate appetitive, but not aversive, learning. Octopamine 142-152 Octopamine beta1 receptor Drosophila melanogaster 153-162 32277043-16 2020 Furthermore, we show that the octopamine-Octbeta1R and dopamine-dDA1 signals together drive both aversive and appetitive learning whereas the octopamine-Octbeta1R and octopamine-OAMB pathways jointly facilitate appetitive, but not aversive, learning. Octopamine 142-152 Octopamine beta1 receptor Drosophila melanogaster 153-162 31810852-7 2020 The Molecular Docking and afterward Molecular Dynamics calculations of formed complexes between octopamine/norepinephrine with beta1- and beta2- adrenergic receptors examined in details the interactions that lead to the formation of stable complexes. Octopamine 96-106 adrenoceptor beta 1 Homo sapiens 127-165 32315567-8 2020 Thus, inhibition of the deamination of lipolytic hormone octopamine by AOC3 represents a novel mechanism by which ZAG might stimulate lipolysis. Octopamine 57-67 amine oxidase copper containing 3 Homo sapiens 71-75 32315567-8 2020 Thus, inhibition of the deamination of lipolytic hormone octopamine by AOC3 represents a novel mechanism by which ZAG might stimulate lipolysis. Octopamine 57-67 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 114-117 32140572-0 2020 Synergic effects of exercise training and octopamine on peroxisome proliferator-activated receptor-gamma coactivator -1a and uncoupling protein 1 mRNA in heart tissue of rat treated with deep frying oil. Octopamine 42-52 PPARG coactivator 1 alpha Rattus norvegicus 56-120 32140572-0 2020 Synergic effects of exercise training and octopamine on peroxisome proliferator-activated receptor-gamma coactivator -1a and uncoupling protein 1 mRNA in heart tissue of rat treated with deep frying oil. Octopamine 42-52 uncoupling protein 1 Rattus norvegicus 125-145 32140572-10 2020 Also, the expression of PGC1alpha and UCP1 was significantly increase in DFO + exercise group, DFO + OCT group, and DFO + OCT + exercise group compare to DFO group (p < 0.05). Octopamine 101-104 PPARG coactivator 1 alpha Rattus norvegicus 24-33 32140572-10 2020 Also, the expression of PGC1alpha and UCP1 was significantly increase in DFO + exercise group, DFO + OCT group, and DFO + OCT + exercise group compare to DFO group (p < 0.05). Octopamine 101-104 uncoupling protein 1 Rattus norvegicus 38-42 32140572-10 2020 Also, the expression of PGC1alpha and UCP1 was significantly increase in DFO + exercise group, DFO + OCT group, and DFO + OCT + exercise group compare to DFO group (p < 0.05). Octopamine 122-125 PPARG coactivator 1 alpha Rattus norvegicus 24-33 32140572-10 2020 Also, the expression of PGC1alpha and UCP1 was significantly increase in DFO + exercise group, DFO + OCT group, and DFO + OCT + exercise group compare to DFO group (p < 0.05). Octopamine 122-125 uncoupling protein 1 Rattus norvegicus 38-42 32140572-11 2020 Based on these findings, exercise and octopamine can be considered as factors affecting the expression of PGC1alpha genes and UCP1 as well as drug poisoning. Octopamine 38-48 PPARG coactivator 1 alpha Rattus norvegicus 106-115 32140572-11 2020 Based on these findings, exercise and octopamine can be considered as factors affecting the expression of PGC1alpha genes and UCP1 as well as drug poisoning. Octopamine 38-48 uncoupling protein 1 Rattus norvegicus 126-130 32097408-0 2020 Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons. Octopamine 0-10 Vesicular glutamate transporter Drosophila melanogaster 48-54 31320626-3 2019 Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Octopamine 221-231 Tyramine receptor tyra-2 Caenorhabditis elegans 102-108 30821508-2 2020 METHODS: DbetaH assay consisted of the enzymatic hydroxylation of tyramine into octopamine, and DA and NE tissues levels were quantified by HPLC-ED. Octopamine 80-90 dopamine beta-hydroxylase Rattus norvegicus 9-15 31533037-7 2019 Our results demonstrate that octopamine controls starvation-induced neural plasticity by regulating Dlp and provides insights into how proteoglycans can influence behavioral and synaptic plasticity. Octopamine 29-39 dally-like Drosophila melanogaster 100-103 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 79-82 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 91-94 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 145-149 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 91-94 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 91-94 31540212-6 2019 The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1. Octopamine 35-45 L1 cell adhesion molecule Mus musculus 270-274 30605598-8 2019 We also obtained data that support the idea that octopamine could bind and possibly be transported by DmDAT. Octopamine 49-59 Dopamine transporter Drosophila melanogaster 102-107 30065850-9 2018 Mutant analyses showed that tbh-1 mutants lacking only octopamine had normal calcium responses, whereas tdc-1 mutants lacking both tyramine and octopamine did not exhibit the calcium decrease in RME. Octopamine 55-65 DOMON domain-containing protein;Tyramine beta-hydroxylase Caenorhabditis elegans 28-33 30357655-3 2018 A sensitive UHPLC based method for the estimation of DBH activity in human sera samples based on separation of substrate tyramine from the product octopamine in 3 min is described here. Octopamine 147-157 dopamine beta-hydroxylase Homo sapiens 53-56 30301853-4 2018 Here we identify neurotransmitter octopamine (OA) as an endogenous ligand for OCTR-1 in immune regulation and show that the OA-producing RIC neurons function in the OCTR-1 neural circuit to suppress innate immunity. Octopamine 34-44 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 78-84 30301853-4 2018 Here we identify neurotransmitter octopamine (OA) as an endogenous ligand for OCTR-1 in immune regulation and show that the OA-producing RIC neurons function in the OCTR-1 neural circuit to suppress innate immunity. Octopamine 34-44 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 165-171 30704713-7 2018 Octopamine (10 muM) resulted in a sustained neuroexcitation during a 30 min exposure, and neuroexcitation after 21 min was blocked by octopamine receptor antagonist, phentolamine (100 muM). Octopamine 0-10 bicoid Drosophila melanogaster 15-18 30704713-7 2018 Octopamine (10 muM) resulted in a sustained neuroexcitation during a 30 min exposure, and neuroexcitation after 21 min was blocked by octopamine receptor antagonist, phentolamine (100 muM). Octopamine 0-10 bicoid Drosophila melanogaster 184-187 30704713-10 2018 It was also found that atropine (10 muM) blocked octopamine"s sustained neuroexcitation, indicating the possibility of cross-talk between these two GPCR pathways. Octopamine 49-59 bicoid Drosophila melanogaster 36-39 30837287-4 2019 Based on screening in Drosophila for increased presynaptic neuropeptides, the receptor protein tyrosine phosphatase (Rptp) Ptp4E was found to post-transcriptionally regulate neuropeptide content in single DCVs at octopamine synapses. Octopamine 213-223 Protein tyrosine phosphatase 4E Drosophila melanogaster 123-128 30808766-7 2019 We further show that the level of tyramine-beta-hydroxylase (TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food deprivation, thus selecting between antagonistic amine actions on motoneurons. Octopamine 106-116 Tyramine beta hydroxylase Drosophila melanogaster 34-59 30808766-7 2019 We further show that the level of tyramine-beta-hydroxylase (TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food deprivation, thus selecting between antagonistic amine actions on motoneurons. Octopamine 106-116 Tyramine beta hydroxylase Drosophila melanogaster 61-64 30808766-8 2019 Therefore, octopamine and tyramine provide global but distinctly different mechanisms to regulate motoneuron excitability and behavioral plasticity, and their antagonistic actions are balanced within a dynamic range by nutritional effects on TBH. Octopamine 11-21 Tyramine beta hydroxylase Drosophila melanogaster 242-245 30065850-9 2018 Mutant analyses showed that tbh-1 mutants lacking only octopamine had normal calcium responses, whereas tdc-1 mutants lacking both tyramine and octopamine did not exhibit the calcium decrease in RME. Octopamine 144-154 Tyrosine decarboxylase Caenorhabditis elegans 104-109 30018540-6 2018 This aversion is due to octopamine release and not tyramine, since in Tyramine-beta-hydroxylase mutants (Tbetah) lacking octopamine, the aversion is suppressed. Octopamine 24-34 Tyramine beta hydroxylase Drosophila melanogaster 70-95 29987037-3 2018 We recently demonstrated that MMP2 activation and follicle rupture are regulated by the neuronal hormone octopamine (OA) and the octopamine receptor in mushroom body (OAMB). Octopamine 105-115 Matrix metalloproteinase 2 Drosophila melanogaster 30-34 30018540-6 2018 This aversion is due to octopamine release and not tyramine, since in Tyramine-beta-hydroxylase mutants (Tbetah) lacking octopamine, the aversion is suppressed. Octopamine 24-34 Tyramine beta hydroxylase Drosophila melanogaster 105-111 30018540-6 2018 This aversion is due to octopamine release and not tyramine, since in Tyramine-beta-hydroxylase mutants (Tbetah) lacking octopamine, the aversion is suppressed. Octopamine 121-131 Tyramine beta hydroxylase Drosophila melanogaster 70-95 30018540-6 2018 This aversion is due to octopamine release and not tyramine, since in Tyramine-beta-hydroxylase mutants (Tbetah) lacking octopamine, the aversion is suppressed. Octopamine 121-131 Tyramine beta hydroxylase Drosophila melanogaster 105-111 30018540-8 2018 Consistent with the requirement for octopamine in biasing the behavioral outcome, Tbetah mutants fail to switch their attraction. Octopamine 36-46 Tyramine beta hydroxylase Drosophila melanogaster 82-88 30018540-11 2018 Pharmacological increases in octopamine signaling in Tbetah mutants increase ethanol attraction and blocking octopamine receptor function reduces ethanol attraction. Octopamine 29-39 Tyramine beta hydroxylase Drosophila melanogaster 53-59 29538302-0 2018 How Tyramine beta-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles. Octopamine 57-67 tyramine beta-hydroxylase Tribolium castaneum 4-29 29382341-8 2018 CONCLUSIONS: Our findings indicate that, as a dual regulator of octopamine and juvenile hormone release, ETH provides a link between stress-induced elevation of ecdysone levels and consequent reduction in fecundity. Octopamine 64-74 Ecdysis triggering hormone Drosophila melanogaster 105-108 29577066-5 2018 TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Octopamine 84-94 Tyramine receptor tyra-2 Caenorhabditis elegans 0-6 29577066-6 2018 Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior. Octopamine 191-201 Tyramine receptor tyra-2 Caenorhabditis elegans 66-72 29311961-4 2017 We found that administrations of octopamine (the invertebrate counterpart of noradrenaline) and dopamine receptor antagonists impair conditioning to associate an olfactory or visual conditioned stimulus (CS) with water or sodium chloride solution (appetitive or aversive unconditioned stimulus, US), respectively, suggesting that specific octopamine and dopamine neurons mediate appetitive and aversive signals, respectively, in conditioning in crickets. Octopamine 339-349 Dopamine 1-like receptor 1 Drosophila melanogaster 96-113 29247240-3 2017 Using genetic and RNA interference approaches, we show that the activity of the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption. Octopamine 120-130 Octopamine receptor in mushroom bodies Drosophila melanogaster 80-84 28715094-9 2017 We show that expression of UAS-Tbetah in octopamine/tyraminergic neurons using Tdc2-Gal4 in Tbetah null mutant flies fully rescued both the aversive learning defects and female sterility observed in Tbetah mutants. Octopamine 41-51 Tyramine beta hydroxylase Drosophila melanogaster 31-37 29114209-7 2017 Release of tyramine/octopamine from VUM (md and mx) neurons in the antennal lobe and mushroom body calyx would target AmTyr1 expressed on ORN and uniglomerular PN presynaptic terminals. Octopamine 20-30 tyramine receptor Apis mellifera 118-124 29064449-7 2017 Interestingly, these aromatic esters were found to exhibit relatively higher binding affinities to OAMB than the receptor"s natural agonist, octopamine. Octopamine 141-151 Octopamine receptor in mushroom bodies Drosophila melanogaster 99-103 28715094-9 2017 We show that expression of UAS-Tbetah in octopamine/tyraminergic neurons using Tdc2-Gal4 in Tbetah null mutant flies fully rescued both the aversive learning defects and female sterility observed in Tbetah mutants. Octopamine 41-51 Tyrosine decarboxylase 2 Drosophila melanogaster 79-83 28105749-0 2017 Octopamine enhances oxidative stress resistance through the fasting-responsive transcription factor DAF-16/FOXO in C. elegans. Octopamine 0-10 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 100-106 28698386-5 2017 Octopamine, produced by the RIC neurons, acts via SER-3 and SER-6 receptors in SIA neurons to promote roaming behaviors characteristic of fasting animals. Octopamine 0-10 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 50-55 28698386-5 2017 Octopamine, produced by the RIC neurons, acts via SER-3 and SER-6 receptors in SIA neurons to promote roaming behaviors characteristic of fasting animals. Octopamine 0-10 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 60-65 28710457-5 2017 Drosophila melanogaster males with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward divergent interspecies D. virilis and D. yakuba females and a decrease in conspecific mating success. Octopamine 74-84 MBD-R2 Drosophila melanogaster 50-57 27031617-1 2016 Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). Octopamine 87-97 trace amine-associated receptor 1 Mus musculus 155-188 27828941-4 2016 Tyramine and octopamine released from neurons expressing tyrosine decarboxylase 2 (Tdc2) signal directly to astrocytes to stimulate Ca2+ increases through the octopamine/tyramine receptor (Oct-TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn modulate downstream dopaminergic neurons. Octopamine 13-23 Octopamine-Tyramine receptor Drosophila melanogaster 189-197 27828941-4 2016 Tyramine and octopamine released from neurons expressing tyrosine decarboxylase 2 (Tdc2) signal directly to astrocytes to stimulate Ca2+ increases through the octopamine/tyramine receptor (Oct-TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn modulate downstream dopaminergic neurons. Octopamine 13-23 water witch Drosophila melanogaster 263-267 27828941-5 2016 Application of tyramine or octopamine to live preparations silenced dopaminergic neurons and this inhibition required astrocytic Oct-TyrR and Wtrw. Octopamine 27-37 Octopamine-Tyramine receptor Drosophila melanogaster 129-137 27828941-5 2016 Application of tyramine or octopamine to live preparations silenced dopaminergic neurons and this inhibition required astrocytic Oct-TyrR and Wtrw. Octopamine 27-37 water witch Drosophila melanogaster 142-146 27828941-8 2016 Our work identifies Oct-TyrR and Wtrw as key components of the astrocytic Ca2+ signalling machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be mediated by astrocytes, and demonstrates that astrocytes are essential for multiple sensory-driven behaviours in Drosophila. Octopamine 131-141 Octopamine-Tyramine receptor Drosophila melanogaster 20-28 27828941-8 2016 Our work identifies Oct-TyrR and Wtrw as key components of the astrocytic Ca2+ signalling machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be mediated by astrocytes, and demonstrates that astrocytes are essential for multiple sensory-driven behaviours in Drosophila. Octopamine 131-141 water witch Drosophila melanogaster 33-37 27754851-0 2016 The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions. Octopamine 35-45 forkhead box, sub-group O Drosophila melanogaster 14-18 27754851-6 2016 We demonstrate that the nearly twofold decline of FOXO expression in foxoBG01018 mutants results in dramatic changes in the metabolism of dopamine and octopamine and the overall response to stress. Octopamine 151-161 forkhead box, sub-group O Drosophila melanogaster 50-54 27754851-7 2016 The absence of FOXO increases tyrosine decarboxylase activity, the first enzyme in octopamine synthesis, and decreases the enzymatic activity of enzymes in dopamine synthesis, alkaline phosphatase and tyrosine hydroxylase, in young Drosophila females. Octopamine 83-93 forkhead box, sub-group O Drosophila melanogaster 15-19 27326831-5 2016 Endogenous octopamine release was stimulated by genetically inserting either the ATP sensitive channel, P2X2, or the red-light sensitive channelrhodopsin, CsChrimson, into cells expressing tyrosine decarboxylase (TDC), an octopamine synthesis enzyme. Octopamine 11-21 Tyrosine decarboxylase 1 Drosophila melanogaster 189-211 27326831-5 2016 Endogenous octopamine release was stimulated by genetically inserting either the ATP sensitive channel, P2X2, or the red-light sensitive channelrhodopsin, CsChrimson, into cells expressing tyrosine decarboxylase (TDC), an octopamine synthesis enzyme. Octopamine 11-21 Tyrosine decarboxylase 1 Drosophila melanogaster 213-216 29368833-0 2016 [Gene dilp6 regulates octopamine metabolism in Drosophila melanogaster]. Octopamine 22-32 Insulin-like peptide 6 Drosophila melanogaster 6-11 29368833-1 2016 The effect of strong hypomorphic mutation of the insulin-like protein gene (dilp6) on metabolism of octopamine (one of the main biogenic amines in insects) was studied in Drosophila melanogaster males and females. Octopamine 100-110 Insulin-like peptide 6 Drosophila melanogaster 76-81 29368833-3 2016 It was demonstrated that the activity of both studied enzymes is decreased under normal conditions in the dilp6 41 mutants (as we previously demonstrated, this is correlated with an increased level of octopamine). Octopamine 202-212 Insulin-like peptide 6 Drosophila melanogaster 106-111 29368833-5 2016 Thus, it was demonstrated for the first time that insulin-like DILP6 protein in drosophila influences the level of octopamine (regulating the activity of the enzyme degrading octopamine). Octopamine 115-125 Insulin-like peptide 6 Drosophila melanogaster 63-68 29368833-5 2016 Thus, it was demonstrated for the first time that insulin-like DILP6 protein in drosophila influences the level of octopamine (regulating the activity of the enzyme degrading octopamine). Octopamine 175-185 Insulin-like peptide 6 Drosophila melanogaster 63-68 27386520-5 2016 During nutrient deprivation, the nuclear receptor DAF-12, known to sense nutritional cues, up-regulates the expression of tbh-1 that encodes tyramine beta-hydroxylase, a key enzyme for octopamine biosynthesis, in the RIC neurons. Octopamine 185-195 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans 50-56 27386520-5 2016 During nutrient deprivation, the nuclear receptor DAF-12, known to sense nutritional cues, up-regulates the expression of tbh-1 that encodes tyramine beta-hydroxylase, a key enzyme for octopamine biosynthesis, in the RIC neurons. Octopamine 185-195 DOMON domain-containing protein;Tyramine beta-hydroxylase Caenorhabditis elegans 122-127 27386520-5 2016 During nutrient deprivation, the nuclear receptor DAF-12, known to sense nutritional cues, up-regulates the expression of tbh-1 that encodes tyramine beta-hydroxylase, a key enzyme for octopamine biosynthesis, in the RIC neurons. Octopamine 185-195 DOMON domain-containing protein;Tyramine beta-hydroxylase Caenorhabditis elegans 141-166 27386520-6 2016 Octopamine induces the expression of the lipase gene lips-6 via its receptor SER-3 in the intestine. Octopamine 0-10 Lipase Caenorhabditis elegans 41-47 27386520-6 2016 Octopamine induces the expression of the lipase gene lips-6 via its receptor SER-3 in the intestine. Octopamine 0-10 LIPaSe related Caenorhabditis elegans 53-59 27386520-6 2016 Octopamine induces the expression of the lipase gene lips-6 via its receptor SER-3 in the intestine. Octopamine 0-10 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 77-82 27092049-3 2016 At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1. Octopamine 211-221 trace amine associated receptor 1 Homo sapiens 49-82 27092049-3 2016 At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1. Octopamine 211-221 trace amine associated receptor 1 Homo sapiens 84-89 27092049-3 2016 At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1. Octopamine 211-221 trace amine associated receptor 1 Homo sapiens 469-474 27939988-13 2017 The functional characterization of two tyramine receptors from the honeybee, AmTAR1 (previously named AmTYR1) and AmTAR2, which respond to tyramine by changing cAMP levels in opposite direction, is an important step towards understanding the actions of tyramine in honeybee behavior and physiology, particularly in comparison to the effects of octopamine. Octopamine 344-354 tyramine receptor Apis mellifera 102-108 27355756-2 2016 One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system. Octopamine 36-46 Tyramine beta hydroxylase Drosophila melanogaster 106-131 27355756-2 2016 One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system. Octopamine 36-46 Tyramine beta hydroxylase Drosophila melanogaster 133-139 27355756-2 2016 One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system. Octopamine 48-50 Tyramine beta hydroxylase Drosophila melanogaster 106-131 27355756-2 2016 One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system. Octopamine 48-50 Tyramine beta hydroxylase Drosophila melanogaster 133-139 27031617-1 2016 Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). Octopamine 87-97 trace amine-associated receptor 1 Mus musculus 190-195 25566191-3 2014 Activity in the DSK-producing neurons is regulated by octopamine. Octopamine 54-64 Drosulfakinin Drosophila melanogaster 16-19 24654910-4 2015 p-Octopamine binds to neuroreceptors in insects that are not present in humans, while exhibiting poor binding to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors in mammalian systems. Octopamine 0-12 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 131-137 26903298-0 2016 Central nervous system promotes thermotolerance via FoxO/DAF-16 activation through octopamine and acetylcholine signaling in Caenorhabditis elegans. Octopamine 83-93 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 57-63 26903298-7 2016 In conclusion, our results show that octopamine and acetylcholine activate DAF-16 in response to stress, but chronic induction of octopamine and acetylcholine is not beneficial for increasing longevity. Octopamine 37-47 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 75-81 24142897-0 2014 Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila. Octopamine 72-82 Transcription factor AP-2 Drosophila melanogaster 49-55 24894156-1 2014 Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine. Octopamine 237-247 trace amine associated receptor 1 Homo sapiens 0-33 24894156-1 2014 Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine. Octopamine 237-247 trace amine associated receptor 1 Homo sapiens 35-40 25411499-6 2014 With this approach, a systemic injection with the receptor ligand octopamine leads to increased cAMP levels in this specific set of hippocampal neurons. Octopamine 66-76 cathelicidin antimicrobial peptide Mus musculus 96-100 24446241-3 2014 In C. elegans, the amine neurotransmitter octopamine induces activation of cAMP response element-binding protein (CREB) in the cholinergic SIA neurons in the absence of food through activation of the Gq-coupled octopamine receptor SER-3 in these neurons. Octopamine 42-52 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 231-236 24819202-5 2014 The Tyramine-beta-hydroxylase (Tbetah) mutant lacks the enzyme catalyzing the final step of octopamine synthesis. Octopamine 92-102 Tyramine beta hydroxylase Drosophila melanogaster 4-29 24819202-5 2014 The Tyramine-beta-hydroxylase (Tbetah) mutant lacks the enzyme catalyzing the final step of octopamine synthesis. Octopamine 92-102 Tyramine beta hydroxylase Drosophila melanogaster 31-37 24819202-8 2014 Systemic application of octopamine or induction of octopamine synthesis by Tbetah expression in a cluster of octopaminergic neurons within the suboesophageal ganglion restored sucrose responsiveness and habituation of octopamine mutants to control level. Octopamine 51-61 Tyramine beta hydroxylase Drosophila melanogaster 75-81 24819202-8 2014 Systemic application of octopamine or induction of octopamine synthesis by Tbetah expression in a cluster of octopaminergic neurons within the suboesophageal ganglion restored sucrose responsiveness and habituation of octopamine mutants to control level. Octopamine 51-61 Tyramine beta hydroxylase Drosophila melanogaster 75-81 25187989-2 2014 In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Octopamine 67-77 Transcription factor AP-2 Drosophila melanogaster 161-167 25187989-2 2014 In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Octopamine 67-77 tiwaz Drosophila melanogaster 179-182 25187989-4 2014 Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Octopamine 56-66 Transcription factor AP-2 Drosophila melanogaster 32-38 25187989-4 2014 Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Octopamine 56-66 tiwaz Drosophila melanogaster 43-46 24852170-0 2014 Octopamine neuromodulation regulates Gr32a-linked aggression and courtship pathways in Drosophila males. Octopamine 0-10 Gustatory receptor 32a Drosophila melanogaster 37-42 24852170-2 2014 Here we demonstrate that the pheromonal signals detected by Gr32a-expressing chemosensory neurons to enhance male aggression are filtered through octopamine (OA, invertebrate equivalent of norepinephrine) neurons. Octopamine 146-156 Gustatory receptor 32a Drosophila melanogaster 60-65 24852170-4 2014 Physiological and anatomical experiments identify Gr32a to octopamine neuron synaptic and functional connections in the suboesophageal ganglion. Octopamine 59-69 Gustatory receptor 32a Drosophila melanogaster 50-55 24446241-5 2014 As seen in ser-3 deletion mutants, octopamine- and food-deprivation-mediated CREB activation was decreased in ser-6 deletion mutants compared with wild-type animals, suggesting that both SER-3 and SER-6 are required for signal transduction. Octopamine 35-45 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 110-115 24446241-5 2014 As seen in ser-3 deletion mutants, octopamine- and food-deprivation-mediated CREB activation was decreased in ser-6 deletion mutants compared with wild-type animals, suggesting that both SER-3 and SER-6 are required for signal transduction. Octopamine 35-45 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 187-192 24446241-5 2014 As seen in ser-3 deletion mutants, octopamine- and food-deprivation-mediated CREB activation was decreased in ser-6 deletion mutants compared with wild-type animals, suggesting that both SER-3 and SER-6 are required for signal transduction. Octopamine 35-45 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 197-202 25438557-1 2014 The influence of suppression of the expression of the Drosophila insulin-like receptor gene (InR) in corpus allatum (the gland-synthesizing juvenile hormone) on octopamine and juvenile hormone metabolism and on the development of the stress-reaction in Drosophila melanogaster females was studied. Octopamine 161-171 Insulin-like receptor Drosophila melanogaster 65-86 24142897-0 2014 Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila. Octopamine 72-82 tiwaz Drosophila melanogaster 60-63 24142897-2 2014 Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine beta-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Octopamine 317-327 Transcription factor AP-2 Drosophila melanogaster 103-107 24142897-2 2014 Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine beta-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Octopamine 317-327 Transcription factor AP-2 Drosophila melanogaster 109-115 24142897-2 2014 Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine beta-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Octopamine 317-327 tiwaz Drosophila melanogaster 146-149 24142897-2 2014 Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine beta-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Octopamine 317-327 potassium channel tetramerization domain containing 15 Homo sapiens 151-157 24142897-3 2014 Furthermore, we reveal that octopamine in turn regulates aggression through the Drosophila cholecystokinin satiation hormone homolog Drosulfakinin (Dsk). Octopamine 28-38 Drosulfakinin Drosophila melanogaster 148-151 24142897-5 2014 We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk. Octopamine 109-119 Transcription factor AP-2 Drosophila melanogaster 70-76 24142897-5 2014 We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk. Octopamine 109-119 tiwaz Drosophila melanogaster 81-84 24142897-5 2014 We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk. Octopamine 109-119 Drosulfakinin Drosophila melanogaster 228-231 21368121-4 2011 Octopamine-evoked neuropeptide release also requires endoplasmic reticulum Ca(2+) mobilization by the ryanodine receptor and the inositol trisphosphate receptor. Octopamine 0-10 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 129-160 23977320-4 2013 In Caenorhabditis elegans, the amine neurotransmitter octopamine activates a CREB homolog, CRH-1, in cholinergic SIA neurons, whereas dopamine suppresses CREB activation by inhibiting octopamine signaling in response to food stimuli. Octopamine 54-64 BZIP domain-containing protein Caenorhabditis elegans 91-96 23977320-4 2013 In Caenorhabditis elegans, the amine neurotransmitter octopamine activates a CREB homolog, CRH-1, in cholinergic SIA neurons, whereas dopamine suppresses CREB activation by inhibiting octopamine signaling in response to food stimuli. Octopamine 184-194 BZIP domain-containing protein Caenorhabditis elegans 91-96 23356740-7 2013 Conversely, the structurally related receptor, CG16766, was internalized by a number of biogenic amines, including octopamine, dopamine, noradrenaline, adrenaline, which also were able to elevate cyclic AMP levels. Octopamine 115-125 Tyramine receptor II Drosophila melanogaster 47-54 22829591-2 2012 Octopamine promotes wakefulness in the fly by acting through the insulin-producing cells (IPCs) in the fly brain. Octopamine 0-10 Insulin-like receptor Drosophila melanogaster 65-72 22829591-7 2012 Interestingly, this effect is mediated at least partially by insulin, suggesting that effects of octopamine on metabolism are independent of its effects on sleep. Octopamine 97-107 Insulin-like receptor Drosophila melanogaster 61-68 23107737-0 2012 Synthesis and structure-activity relationships and effects of phenylpropanoid amides of octopamine and dopamine on tyrosinase inhibition and antioxidation. Octopamine 88-98 tyrosinase Homo sapiens 115-125 23107737-1 2012 Phenylpropanoid amides of octopamine (OA) 1a-1e and dopamine (DA) 2a-2e were synthesised and the structure-activity relationships (SARs) for antioxidant and tyrosinase inhibition activities were analysed. Octopamine 26-36 tyrosinase Homo sapiens 157-167 21478261-7 2011 From its desensitized state, DmOctalpha1Rb is resensitized by dephosphorylation, and a new Ca(2+) signal occurs on octopamine stimulation. Octopamine 115-125 Octopamine receptor in mushroom bodies Drosophila melanogaster 29-42 21478261-9 2011 We expect that the detailed knowledge of DmOctalpha1Rb-dependent signal transduction fosters the identification of specific drugs that can be used for GPCR-mediated pest control, since octopamine serves important physiological and behavioral functions in arthropods. Octopamine 185-195 Octopamine receptor in mushroom bodies Drosophila melanogaster 41-54 21478261-9 2011 We expect that the detailed knowledge of DmOctalpha1Rb-dependent signal transduction fosters the identification of specific drugs that can be used for GPCR-mediated pest control, since octopamine serves important physiological and behavioral functions in arthropods. Octopamine 185-195 Octopamine receptor in mushroom bodies Drosophila melanogaster 151-155 23681219-7 2013 Using RNA interference, we show that the octopamine receptor AmOA1 (homolog of the Drosophila OAMB receptor) is involved in the octopamine effect. Octopamine 41-51 octopamine receptor Apis mellifera 61-66 24101486-0 2013 Drosophila seminal protein ovulin mediates ovulation through female octopamine neuronal signaling. Octopamine 68-78 Accessory gland protein 26Aa Drosophila melanogaster 27-33 24003139-5 2013 Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Octopamine 145-155 Tyrosine decarboxylase 2 Drosophila melanogaster 55-59 23331098-0 2013 nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster. Octopamine 14-24 nicotinic Acetylcholine Receptor beta1 Drosophila melanogaster 0-5 23331098-6 2013 By using different genetic tools we demonstrate that the BA whose efflux is induced by nAChR activation is octopamine (Oct). Octopamine 107-117 nicotinic Acetylcholine Receptor beta1 Drosophila melanogaster 87-92 23331098-6 2013 By using different genetic tools we demonstrate that the BA whose efflux is induced by nAChR activation is octopamine (Oct). Octopamine 119-122 nicotinic Acetylcholine Receptor beta1 Drosophila melanogaster 87-92 23352695-7 2013 Combined, our results suggest that a novel Orco-mediated olfactory pathway that gains sensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches the valence of a key environmental stimulus in a behavioral-state-dependent manner. Octopamine 132-142 Odorant receptor co-receptor Drosophila melanogaster 43-47 23055498-3 2012 In this study, we find that tyramine beta hydroxylase (TbetaH) mutant males unable to synthesize octopamine (OA) showed impaired courtship conditioning, which could be rescued by transgenic TbetaH expression in the CNS. Octopamine 97-107 Tyramine beta hydroxylase Drosophila melanogaster 28-53 23055498-3 2012 In this study, we find that tyramine beta hydroxylase (TbetaH) mutant males unable to synthesize octopamine (OA) showed impaired courtship conditioning, which could be rescued by transgenic TbetaH expression in the CNS. Octopamine 97-107 Tyramine beta hydroxylase Drosophila melanogaster 55-61 23055498-3 2012 In this study, we find that tyramine beta hydroxylase (TbetaH) mutant males unable to synthesize octopamine (OA) showed impaired courtship conditioning, which could be rescued by transgenic TbetaH expression in the CNS. Octopamine 97-107 Tyramine beta hydroxylase Drosophila melanogaster 190-196 23284851-6 2012 Odor-evoked ethanol preference requires the function of Tbh (Tyramine beta hydroxalyse), the rate-limiting enzyme of octopamine synthesis. Octopamine 117-127 Tyramine beta hydroxylase Drosophila melanogaster 56-59 23284851-6 2012 Odor-evoked ethanol preference requires the function of Tbh (Tyramine beta hydroxalyse), the rate-limiting enzyme of octopamine synthesis. Octopamine 117-127 Tyramine beta hydroxylase Drosophila melanogaster 61-86