PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32386503-2 2021 OBJECTIVES: One of the objectives of the present study was to demonstrate the anxiolytic behavioral effect of beta-caryophyllene (beta-CBP) in female Swiss mice, as well as to investigate the molecular mechanisms underlying the results obtained. caryophyllene 110-128 CREB binding protein Mus musculus 135-138 33069159-9 2021 Furthermore, pharmacological blockade of mu opioid receptor or Toll-like receptors complex failed to alter, while blockade of peroxisome proliferator-activated receptors (PPARalpha, PPARgamma) reversed BCP-induced reduction in cocaine self-administration, suggesting the involvement of PPARalpha and PPARgamma in BCP"s action. caryophyllene 202-205 peroxisome proliferator activated receptor alpha Mus musculus 171-180 33069159-9 2021 Furthermore, pharmacological blockade of mu opioid receptor or Toll-like receptors complex failed to alter, while blockade of peroxisome proliferator-activated receptors (PPARalpha, PPARgamma) reversed BCP-induced reduction in cocaine self-administration, suggesting the involvement of PPARalpha and PPARgamma in BCP"s action. caryophyllene 202-205 peroxisome proliferator activated receptor gamma Mus musculus 182-191 33069159-11 2021 We found that BCP is more effective in attenuation of cocaine-enhanced oICSS than eICSS, the former driven by optical activation of midbrain dopamine neurons in DAT-cre mice. caryophyllene 14-17 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 161-164 33530917-9 2021 In the doxorubicin-induced chemobrain model, beta-caryophyllene at 100 mg/kg significantly elevated acetylcholinesterase and catalase levels and lowered lipid peroxidation compared to the disease control. caryophyllene 45-63 acetylcholinesterase Rattus norvegicus 100-120 33530917-9 2021 In the doxorubicin-induced chemobrain model, beta-caryophyllene at 100 mg/kg significantly elevated acetylcholinesterase and catalase levels and lowered lipid peroxidation compared to the disease control. caryophyllene 45-63 catalase Rattus norvegicus 125-133 33530917-10 2021 In the novel object recognition task, beta-caryophyllene at 100 mg/kg significantly improved recognition index and discrimination index in the treated animals compared to the disease control, with a significant increase in catalase and decrease in lipid peroxidation in both hippocampus and frontal cortex. caryophyllene 38-56 catalase Rattus norvegicus 223-231 33501847-6 2021 Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. caryophyllene 35-53 apoptotic peptidase activating factor 1 Homo sapiens 115-153 33501847-6 2021 Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. caryophyllene 35-53 caspase 9 Homo sapiens 154-163 33069159-0 2021 Beta-caryophyllene inhibits cocaine self-administration by activation of PPARalpha and PPARgamma: repurposing a FDA-approved food additive for cocaine use disorder. caryophyllene 0-18 peroxisome proliferator activated receptor alpha Mus musculus 73-82 33069159-0 2021 Beta-caryophyllene inhibits cocaine self-administration by activation of PPARalpha and PPARgamma: repurposing a FDA-approved food additive for cocaine use disorder. caryophyllene 0-18 peroxisome proliferator activated receptor gamma Mus musculus 87-96 33447946-6 2021 A principal component analysis of these aphid performance parameters and terpene production in the trichome mutants indicated that longevity and fecundity of M. euphorbiae were negatively correlated with production of the TPS12-derived sesquiterpenes beta-caryophyllene and alpha-humulene. caryophyllene 251-269 beta caryophyllene/humulene synthase Solanum lycopersicum 222-227 33579467-0 2021 beta-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 97-100 33271195-4 2021 To assess whether this is the case, the effect of BCP on the expression and activity of NAD(P)H quinone oxidoreductase (NQO1) was evaluated in mice after the administration of MPTP. caryophyllene 50-53 NAD(P)H dehydrogenase, quinone 1 Mus musculus 120-124 33271195-11 2021 The results showed that BCP inhibits oxidative stress-induced cell death of dopaminergic neurons exposed to MPTP at the same time as it enhances the expression and enzymatic activity of NQO1. caryophyllene 24-27 NAD(P)H dehydrogenase, quinone 1 Mus musculus 186-190 33271195-13 2021 Hence, BCP appears to achieve at least some of its antioxidant effects by augmenting NQO1 activity, which protects cells from MPTP toxicity. caryophyllene 7-10 NAD(P)H dehydrogenase, quinone 1 Mus musculus 85-89 33391143-7 2020 BCP reduced neurologic deficits, cerebral infarct volume, and pathological damage in MCAO mice and caused CI-AMPARs to translocate to synaptic membranes in the hippocampus; surface expression of CI-AMPARs was also decreased in MCAO mice. caryophyllene 0-3 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 109-115 33288697-4 2020 The frequency of HMR events was highly correlated with an ambient temperature lower than 15 C. BCP/BCPO (beta-caryophyllene/caryophyllene oxide) in fresh horse manure was found to drive HMR behavior and attenuated the cold sensitivity of mice by directly targeting and inhibiting transient receptor potential melastatin 8 (TRPM8), an archetypical cold-activated ion channel of mammals. caryophyllene 106-124 transient receptor potential cation channel, subfamily M, member 8 Mus musculus 324-329 33288697-4 2020 The frequency of HMR events was highly correlated with an ambient temperature lower than 15 C. BCP/BCPO (beta-caryophyllene/caryophyllene oxide) in fresh horse manure was found to drive HMR behavior and attenuated the cold sensitivity of mice by directly targeting and inhibiting transient receptor potential melastatin 8 (TRPM8), an archetypical cold-activated ion channel of mammals. caryophyllene 106-124 transient receptor potential cation channel, subfamily M, member 8 Mus musculus 281-322 33391143-10 2020 Interestingly, H-89 treatment significantly disrupted the BCP-mediated facilitation of CI-AMPAR translocation to the synaptic membrane surface and substantially attenuated BCP-induced protection against acute ischemic stroke. caryophyllene 58-61 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 90-95 33391143-11 2020 Additionally, inhibition the cAMP/PKA pathway not only reduced BCP-induced inhibition of AMPAR-mediated excitatory postsynaptic currents in the hippocampal CA1 region but also decreased the effect of BCP-mediated protection against post-acute ischemic stroke cognitive impairment. caryophyllene 63-66 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 89-94 33114208-6 2020 In Epac1-CB2-HEK293 responder cells, the terpenoid beta-caryophyllene significantly modified the cAMP response through CB2. caryophyllene 51-69 Rap guanine nucleotide exchange factor 3 Homo sapiens 3-8 33114208-6 2020 In Epac1-CB2-HEK293 responder cells, the terpenoid beta-caryophyllene significantly modified the cAMP response through CB2. caryophyllene 51-69 cannabinoid receptor 2 Homo sapiens 9-12 33114208-6 2020 In Epac1-CB2-HEK293 responder cells, the terpenoid beta-caryophyllene significantly modified the cAMP response through CB2. caryophyllene 51-69 cannabinoid receptor 2 Homo sapiens 119-122 33868981-6 2021 However, treatment with sildenafil and/ or beta-Caryophyllene significantly reduced the activities of AChE, PDE-5", arginase, ADA, and ACE in penile tissues of PD-induced rats. caryophyllene 43-61 acetylcholinesterase Rattus norvegicus 102-106 33868981-6 2021 However, treatment with sildenafil and/ or beta-Caryophyllene significantly reduced the activities of AChE, PDE-5", arginase, ADA, and ACE in penile tissues of PD-induced rats. caryophyllene 43-61 adenosine deaminase Rattus norvegicus 126-129 33868981-6 2021 However, treatment with sildenafil and/ or beta-Caryophyllene significantly reduced the activities of AChE, PDE-5", arginase, ADA, and ACE in penile tissues of PD-induced rats. caryophyllene 43-61 angiotensin I converting enzyme Rattus norvegicus 135-138 32416450-5 2020 Our results showed that BCP inhibited HG-induced cell proliferation, ROS production and NADPH oxidase (NOX) 2/4 expression. caryophyllene 24-27 cytochrome b-245 beta chain Homo sapiens 88-111 32359221-0 2020 JAK1/STAT3 regulatory effect of beta-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation. caryophyllene 32-50 Janus kinase 1 Homo sapiens 0-4 32359221-0 2020 JAK1/STAT3 regulatory effect of beta-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation. caryophyllene 32-50 signal transducer and activator of transcription 3 Homo sapiens 5-10 32359221-7 2020 Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level. caryophyllene 168-171 Janus kinase 1 Homo sapiens 39-53 32359221-7 2020 Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level. caryophyllene 168-171 signal transducer and activator of transcription 3 Homo sapiens 54-104 32359221-7 2020 Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level. caryophyllene 168-171 Janus kinase 1 Homo sapiens 106-110 32359221-7 2020 Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level. caryophyllene 168-171 signal transducer and activator of transcription 3 Homo sapiens 111-116 32359221-8 2020 Overall results suggest that the treatment of MG-63 cells with BCP promotes apoptosis and inflammation via ROS and JAK1/STAT3 signaling pathway. caryophyllene 63-66 Janus kinase 1 Homo sapiens 115-119 32359221-8 2020 Overall results suggest that the treatment of MG-63 cells with BCP promotes apoptosis and inflammation via ROS and JAK1/STAT3 signaling pathway. caryophyllene 63-66 signal transducer and activator of transcription 3 Homo sapiens 120-125 33013287-0 2020 The CB2 Agonist beta-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain. caryophyllene 16-34 cannabinoid receptor 2 Rattus norvegicus 4-7 32416450-6 2020 BCP exhibited anti-inflammatory activity with decreased levels of TNF-alpha, IL-1beta, IL-6 in HG-induced MCs. caryophyllene 0-3 tumor necrosis factor Homo sapiens 66-75 32416450-6 2020 BCP exhibited anti-inflammatory activity with decreased levels of TNF-alpha, IL-1beta, IL-6 in HG-induced MCs. caryophyllene 0-3 interleukin 1 alpha Homo sapiens 77-85 32416450-6 2020 BCP exhibited anti-inflammatory activity with decreased levels of TNF-alpha, IL-1beta, IL-6 in HG-induced MCs. caryophyllene 0-3 interleukin 6 Homo sapiens 87-91 32416450-7 2020 Moreover, BCP treatment suppressed the HG-induced secretion of fibronectin (FN) and collagen IV (Col IV) in MCs. caryophyllene 10-13 fibronectin 1 Homo sapiens 63-74 32416450-8 2020 Furthermore, BCP suppressed the NF-kappaB activation and enhanced the Nrf2 activation in HG-induced MCs. caryophyllene 13-16 nuclear factor kappa B subunit 1 Homo sapiens 32-41 32416450-8 2020 Furthermore, BCP suppressed the NF-kappaB activation and enhanced the Nrf2 activation in HG-induced MCs. caryophyllene 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 32416450-9 2020 However, inhibition of Nrf2 attenuated the protective effects of BCP on HG-induced MCs, while inhibition of NF-kappaB enhanced the nephro-protective effects of BCP on MCs. caryophyllene 160-163 nuclear factor kappa B subunit 1 Homo sapiens 108-117 32416450-10 2020 In conclusion, these findings demonstrated that BCP executed protective effects on HG-induced MCs via regulating NF-kappaB and Nrf2 signaling pathways. caryophyllene 48-51 nuclear factor kappa B subunit 1 Homo sapiens 113-122 32416450-10 2020 In conclusion, these findings demonstrated that BCP executed protective effects on HG-induced MCs via regulating NF-kappaB and Nrf2 signaling pathways. caryophyllene 48-51 NFE2 like bZIP transcription factor 2 Homo sapiens 127-131 32538090-0 2020 A Concise Bioinspired Semisynthesis of Rumphellaones A-C and Their C-8 Epimers from beta-Caryophyllene. caryophyllene 84-102 homeobox C8 Homo sapiens 67-70 32343912-1 2020 Re: "beta-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice" (J Med Food [Epub ahead of print]; DOI: 10.1089/jmf.2019.0302). caryophyllene 5-23 glial fibrillary acidic protein Mus musculus 72-103 32560286-0 2020 beta-Caryophyllene Reduces the Inflammatory Phenotype of Periodontal Cells by Targeting CB2 Receptors. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 88-91 32560286-3 2020 The aim of this study was to evaluate the therapeutic potential of beta-Caryophyllene (BCP), a CB2 agonist, in an in vitro model of oral mucositis. caryophyllene 67-85 cannabinoid receptor 2 Homo sapiens 95-98 32560286-3 2020 The aim of this study was to evaluate the therapeutic potential of beta-Caryophyllene (BCP), a CB2 agonist, in an in vitro model of oral mucositis. caryophyllene 87-90 cannabinoid receptor 2 Homo sapiens 95-98 32560286-7 2020 BCP blunted the LPS-induced inflammatory phenotype and this effect was reverted by the CB2 antagonist AM630. caryophyllene 0-3 cannabinoid receptor 2 Homo sapiens 87-90 31997410-10 2020 Beta-caryophyllene is a CB2 receptor agonist shown to have insulinotropic activity. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 24-27 31762173-0 2020 Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracts parasitoids. caryophyllene 22-35 (-)-germacrene D synthase-like Gossypium hirsutum 50-56 31762173-3 2020 In order to investigate the potential pest management function of (E)-beta-caryophyllene in cotton plants, the (E)-beta-caryophyllene synthase gene (GhTPS1) was inserted into Gossypium hirsutum variety R15 to generate overexpression lines. caryophyllene 66-88 (-)-germacrene D synthase-like Gossypium hirsutum 149-155 32340197-0 2020 beta-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 78-81 32340197-2 2020 b-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that showed an important anti-inflammatory effect through the interaction of CB2 and peroxisome proliferator-activated receptor gamma (PPARg) receptors. caryophyllene 0-15 cannabinoid receptor 2 Homo sapiens 27-49 32340197-2 2020 b-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that showed an important anti-inflammatory effect through the interaction of CB2 and peroxisome proliferator-activated receptor gamma (PPARg) receptors. caryophyllene 0-15 cannabinoid receptor 2 Homo sapiens 51-54 32340197-2 2020 b-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that showed an important anti-inflammatory effect through the interaction of CB2 and peroxisome proliferator-activated receptor gamma (PPARg) receptors. caryophyllene 0-15 cannabinoid receptor 2 Homo sapiens 141-144 32252311-0 2020 Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by beta-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. caryophyllene 81-99 signal transducer and activator of transcription 3 Homo sapiens 14-19 32252311-6 2020 A lowered expression of doxorubicin-induced STAT3 activation was found in the presence of beta-caryophyllene in both cancer and normal cholangiocytes. caryophyllene 90-108 signal transducer and activator of transcription 3 Homo sapiens 44-49 32252311-8 2020 This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by beta-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent. caryophyllene 105-123 signal transducer and activator of transcription 3 Homo sapiens 45-50 31883107-2 2020 Recent studies indicate that BCP is a cannabinoid CB2 receptor (CB2R) agonist with medical benefits for a number of human diseases. caryophyllene 29-32 cannabinoid receptor 2 (macrophage) Mus musculus 50-53 31883107-2 2020 Recent studies indicate that BCP is a cannabinoid CB2 receptor (CB2R) agonist with medical benefits for a number of human diseases. caryophyllene 29-32 cannabinoid receptor 2 (macrophage) Mus musculus 64-68 31883107-7 2020 Genetic deletion of CB2Rs in CB2-knockout mice blocked the reduction in nicotine self-administration produced only by low doses, but not high doses, of BCP, suggesting the involvement of both CB2 and non-CB2 receptor mechanisms. caryophyllene 152-155 cannabinoid receptor 2 (macrophage) Mus musculus 20-23 31883107-7 2020 Genetic deletion of CB2Rs in CB2-knockout mice blocked the reduction in nicotine self-administration produced only by low doses, but not high doses, of BCP, suggesting the involvement of both CB2 and non-CB2 receptor mechanisms. caryophyllene 152-155 cannabinoid receptor 2 (macrophage) Mus musculus 29-32 31883107-7 2020 Genetic deletion of CB2Rs in CB2-knockout mice blocked the reduction in nicotine self-administration produced only by low doses, but not high doses, of BCP, suggesting the involvement of both CB2 and non-CB2 receptor mechanisms. caryophyllene 152-155 cannabinoid receptor 2 (macrophage) Mus musculus 29-32 31883107-9 2020 Lastly, BCP also attenuated BSR maintained by optogenetic stimulation of dopamine (DA) neurons in the ventral tegmental area in DAT-cre mice, suggesting the involvement of a DA-dependent mechanism in BCP"s action. caryophyllene 8-11 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 128-131 31883107-10 2020 CONCLUSIONS AND IMPLICATIONS: The present findings suggest that BCP has significant anti-nicotine effects via both CB2 and non-CB2 receptor mechanisms, and therefore, deserves further study as a potential new pharmacotherapy for cigarette smoking cessation. caryophyllene 64-67 cannabinoid receptor 2 (macrophage) Mus musculus 115-118 31883107-10 2020 CONCLUSIONS AND IMPLICATIONS: The present findings suggest that BCP has significant anti-nicotine effects via both CB2 and non-CB2 receptor mechanisms, and therefore, deserves further study as a potential new pharmacotherapy for cigarette smoking cessation. caryophyllene 64-67 cannabinoid receptor 2 (macrophage) Mus musculus 127-139 32065089-11 2020 Furthermore, levels of caspase-3 were increased by metaxalone or beta-caryophyllene and enhanced by their combination. caryophyllene 65-83 caspase 3 Mus musculus 23-32 31862467-3 2020 beta-Caryophyllene (BCP) is a CB2 agonist that exhibited anti-inflammatory, analgesic effects but minimal psychoactive effects. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 30-33 31862467-3 2020 beta-Caryophyllene (BCP) is a CB2 agonist that exhibited anti-inflammatory, analgesic effects but minimal psychoactive effects. caryophyllene 20-23 cannabinoid receptor 2 Homo sapiens 30-33 31862467-8 2020 Also BCP improved the stress-related changes in the hippocampal expression of COX-2, BDNF, and CB2 receptor expression. caryophyllene 5-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 78-83 31862467-8 2020 Also BCP improved the stress-related changes in the hippocampal expression of COX-2, BDNF, and CB2 receptor expression. caryophyllene 5-8 brain derived neurotrophic factor Homo sapiens 85-89 31862467-8 2020 Also BCP improved the stress-related changes in the hippocampal expression of COX-2, BDNF, and CB2 receptor expression. caryophyllene 5-8 cannabinoid receptor 2 Homo sapiens 95-98 32237496-3 2020 In order to investigate whether beta-caryophyllene(BCP) could protect neurons from cerebral I/R injury by regulating auto-phagy, C57 BL/6 J male mice were randomly divided into sham operation group, model group, and drug-administered group. caryophyllene 32-50 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Mus musculus 51-54 31963614-8 2020 Docking studies found that the binding site of caryophyllane sesquiterpene was next to the ATP binding domain of P-gp and that beta-caryophyllene possessed the stronger binding affinity and higher inhibition potential calculated by MM-PBSA. caryophyllene 127-145 ATP binding cassette subfamily B member 1 Homo sapiens 113-117 31936396-0 2020 Meroterpene-Like alpha-Glucosidase Inhibitors Based on Biomimetic Reactions Starting from beta-Caryophyllene. caryophyllene 90-108 sucrase-isomaltase Homo sapiens 17-34 31936396-1 2020 BACKGROUND: Natural meroterpenes derived from phloroglucinols and beta-caryophyllene have shown high inhibitory activity against alpha-glucosidase or cancer cells, however, the chemical diversity of this type of skeletons in Nature is limited. caryophyllene 66-84 sucrase-isomaltase Homo sapiens 129-146 31936396-2 2020 METHODS: To expand the chemical space and explore their inhibitory activities against alpha-glucosidase (EC 3.2.1.20), we employed beta-caryophyllene and some natural moieties (4-hydroxycoumarins, lawsone or syncarpic acid) to synthesize new types of meroterpene-like skeletons. caryophyllene 131-149 sucrase-isomaltase Homo sapiens 86-103 30652534-5 2020 After docking of known negative CB2 allosteric modulators (NAMs), dihydro-gambogic acid (DHGA) and trans-beta-caryophyllene (TBC) (note that TBC also shows agonist activity), at the predicted allosteric sites, the best total complex with CB2, CP55,940 and NAM was embedded into a hydrated lipid bilayer and subjected to a 200 ns MD simulation. caryophyllene 99-123 cannabinoid receptor 2 Homo sapiens 32-35 30652534-5 2020 After docking of known negative CB2 allosteric modulators (NAMs), dihydro-gambogic acid (DHGA) and trans-beta-caryophyllene (TBC) (note that TBC also shows agonist activity), at the predicted allosteric sites, the best total complex with CB2, CP55,940 and NAM was embedded into a hydrated lipid bilayer and subjected to a 200 ns MD simulation. caryophyllene 141-144 cannabinoid receptor 2 Homo sapiens 32-35 30652534-5 2020 After docking of known negative CB2 allosteric modulators (NAMs), dihydro-gambogic acid (DHGA) and trans-beta-caryophyllene (TBC) (note that TBC also shows agonist activity), at the predicted allosteric sites, the best total complex with CB2, CP55,940 and NAM was embedded into a hydrated lipid bilayer and subjected to a 200 ns MD simulation. caryophyllene 141-144 cannabinoid receptor 2 Homo sapiens 238-241 30652534-5 2020 After docking of known negative CB2 allosteric modulators (NAMs), dihydro-gambogic acid (DHGA) and trans-beta-caryophyllene (TBC) (note that TBC also shows agonist activity), at the predicted allosteric sites, the best total complex with CB2, CP55,940 and NAM was embedded into a hydrated lipid bilayer and subjected to a 200 ns MD simulation. caryophyllene 99-123 cannabinoid receptor 2 Homo sapiens 238-241 30652534-5 2020 After docking of known negative CB2 allosteric modulators (NAMs), dihydro-gambogic acid (DHGA) and trans-beta-caryophyllene (TBC) (note that TBC also shows agonist activity), at the predicted allosteric sites, the best total complex with CB2, CP55,940 and NAM was embedded into a hydrated lipid bilayer and subjected to a 200 ns MD simulation. caryophyllene 125-128 cannabinoid receptor 2 Homo sapiens 32-35 31892132-7 2019 A CB2 receptor antagonist (AM 630), but not a CB1 receptor antagonist (AM 251), antagonized BCP attenuation of established ddC-induced mechanical allodynia. caryophyllene 92-95 cannabinoid receptor 2 (macrophage) Mus musculus 2-5 31892132-8 2019 beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. caryophyllene 0-18 interleukin 1 beta Mus musculus 67-85 31892132-8 2019 beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. caryophyllene 0-18 tumor necrosis factor Mus musculus 87-114 31892132-8 2019 beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. caryophyllene 0-18 interferon gamma Mus musculus 119-135 31892132-8 2019 beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. caryophyllene 0-18 mitogen-activated protein kinase 3 Mus musculus 216-222 31841509-2 2019 Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). caryophyllene 28-46 cannabinoid receptor 2 (macrophage) Mus musculus 66-88 31841509-2 2019 Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). caryophyllene 28-46 cannabinoid receptor 2 (macrophage) Mus musculus 90-93 31711937-2 2019 beta-Caryophyllene (BCP), a natural and selective CB2 agonist, possesses several protective effects. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 50-53 31711937-2 2019 beta-Caryophyllene (BCP), a natural and selective CB2 agonist, possesses several protective effects. caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 50-53 31610207-5 2019 The optimal dose of BCP, 72 mg/kg body weight, inhibited microglial activation and reduced the secretion of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 by microglia of WT mice. caryophyllene 20-23 interleukin 1 beta Mus musculus 134-156 31766439-8 2019 Based on our findings, we believe that CB2R activation may represent a viable therapeutic target for IC, and that drugs that activate CB2R, such as the generally regarded as safe (GRAS) dietary sesquiterpenoid, BCP, may serve as an adjunct and/or alternative treatment option for alleviating symptoms of inflammation and pain in the management of IC. caryophyllene 211-214 cannabinoid receptor 2 (macrophage) Mus musculus 134-138 31610207-5 2019 The optimal dose of BCP, 72 mg/kg body weight, inhibited microglial activation and reduced the secretion of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 by microglia of WT mice. caryophyllene 20-23 tumor necrosis factor Mus musculus 158-191 31610207-0 2019 beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway. caryophyllene 0-18 toll-like receptor 4 Mus musculus 119-123 31610207-1 2019 AIMS: The objective of the study was to determine whether beta-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway. caryophyllene 58-76 toll-like receptor 4 Mus musculus 239-243 31610207-5 2019 The optimal dose of BCP, 72 mg/kg body weight, inhibited microglial activation and reduced the secretion of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 by microglia of WT mice. caryophyllene 20-23 interleukin 6 Mus musculus 197-201 31610207-1 2019 AIMS: The objective of the study was to determine whether beta-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway. caryophyllene 78-81 toll-like receptor 4 Mus musculus 239-243 31610207-6 2019 BCP inhibited the level of TLR4 in WT mice, and partially reduced neurologic deficits, infarct volume, and brain edema in TLR4 KO mice. caryophyllene 0-3 toll-like receptor 4 Mus musculus 27-31 31610207-6 2019 BCP inhibited the level of TLR4 in WT mice, and partially reduced neurologic deficits, infarct volume, and brain edema in TLR4 KO mice. caryophyllene 0-3 toll-like receptor 4 Mus musculus 122-126 31610207-7 2019 Importantly, BCP reduced the number of activated M1-type microglia and increased the number of M2-type microglia in the ipsilateral cortex of both WT and TLR4 KO mice. caryophyllene 13-16 toll-like receptor 4 Mus musculus 154-158 31610207-8 2019 In vitro, BCP decreased the secretion of proinflammatory cytokines induced by LPS plus IFN-gamma, downregulated the level of TLR4 protein, and polarized microglia towards the M2 phenotype. caryophyllene 10-13 toll-like receptor 4 Mus musculus 125-129 31610207-9 2019 SIGNIFICANCES: The decrease in TLR4 activity mediated, at least in part, the anti-inflammatory effects of BCP and its ability to shift microglia polarization from the M1 to M2 phenotype. caryophyllene 106-109 toll-like receptor 4 Mus musculus 31-35 31798452-10 2019 Curcumin, flavocoxid and beta-caryophyllene suppressed IL-1beta expression with different IC50. caryophyllene 25-43 interleukin 1 alpha Homo sapiens 55-63 31583906-4 2022 Cells treated with BCP, in a dose-dependent manner, exhibited morphological changes, showed lower cell growth, underwent apoptosis and lost the ability to metastasis through the suppression of NF-k B via PI3K/AKT signalling pathway. caryophyllene 19-22 AKT serine/threonine kinase 1 Homo sapiens 209-212 31650795-11 2019 On the other hand, the beta-caryophyllene group showed significant improvement in nausea (p=0.025) and epigastric pain (p=0.018), as well as a decrease in the serum IL-1beta levels (p=0.038). caryophyllene 23-41 interleukin 1 alpha Homo sapiens 165-173 31173795-0 2019 The cannabinoid receptor 2 agonist, beta-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice. caryophyllene 36-54 cannabinoid receptor 2 (macrophage) Mus musculus 4-26 31635244-9 2019 beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1. caryophyllene 6-19 cyclin D1 Homo sapiens 67-76 31635244-9 2019 beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1. caryophyllene 6-19 cyclin dependent kinase 2 Homo sapiens 88-140 31635244-9 2019 beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1. caryophyllene 6-19 cyclin dependent kinase inhibitor 1A Homo sapiens 186-193 31635244-9 2019 beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1. caryophyllene 6-19 cyclin dependent kinase inhibitor 1A Homo sapiens 194-198 31635244-9 2019 beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1. caryophyllene 6-19 cyclin dependent kinase inhibitor 1B Homo sapiens 203-210 31583906-5 2022 These results elucidate that the inhibition of NF-k B and PI3K/AKT is one of the most important mechanism by which BCP suppresses cancer cell proliferation and enhances apoptosis. caryophyllene 115-118 AKT serine/threonine kinase 1 Homo sapiens 63-66 31408659-6 2019 KEY FINDINGS: Monotherapy with BCP or MTX or LEF as well as MTX + LEF significantly reduced paw thickness and arthritic index; the histopathological changes in hind paw joints were recovered; and oxidative stress and tumor necrosis factor-alpha (TNF-alpha) levels in arthritic rats were reduced. caryophyllene 31-34 tumor necrosis factor Rattus norvegicus 217-244 31408659-6 2019 KEY FINDINGS: Monotherapy with BCP or MTX or LEF as well as MTX + LEF significantly reduced paw thickness and arthritic index; the histopathological changes in hind paw joints were recovered; and oxidative stress and tumor necrosis factor-alpha (TNF-alpha) levels in arthritic rats were reduced. caryophyllene 31-34 tumor necrosis factor Rattus norvegicus 246-255 31370242-0 2019 beta-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-gamma Receptors. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 109-112 31370242-0 2019 beta-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-gamma Receptors. caryophyllene 0-18 peroxisome proliferator activated receptor gamma Mus musculus 117-127 31370242-1 2019 beta-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 30-52 31370242-1 2019 beta-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 54-57 31370242-1 2019 beta-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 30-52 31370242-1 2019 beta-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 54-57 31370242-6 2019 BCP significantly hampered the severity of the disease, reduced relevant pro-inflammatory cytokines, and increased the anti-inflammatory cytokine IL-13. caryophyllene 0-3 interleukin 13 Mus musculus 146-151 31370242-10 2019 Finally, BCP reduced NF-kB activation and increased PGC-1alpha and PPAR-gamma expression in human articular chondrocytes stimulated with LPS. caryophyllene 9-12 PPARG coactivator 1 alpha Homo sapiens 52-62 31370242-10 2019 Finally, BCP reduced NF-kB activation and increased PGC-1alpha and PPAR-gamma expression in human articular chondrocytes stimulated with LPS. caryophyllene 9-12 peroxisome proliferator activated receptor gamma Homo sapiens 67-77 31370242-12 2019 These results suggest that BCP ameliorates arthritis through a cross-talk between CB2 and PPAR-gamma. caryophyllene 27-30 cannabinoid receptor 2 (macrophage) Mus musculus 82-85 31370242-12 2019 These results suggest that BCP ameliorates arthritis through a cross-talk between CB2 and PPAR-gamma. caryophyllene 27-30 peroxisome proliferator activated receptor gamma Mus musculus 90-100 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 adrenoceptor beta 2 Homo sapiens 162-167 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 dopamine receptor D2 Homo sapiens 169-173 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 estrogen receptor 1 Homo sapiens 175-179 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 potassium voltage-gated channel subfamily H member 2 Homo sapiens 181-186 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 nuclear receptor subfamily 1 group H member 4 Homo sapiens 188-193 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 nuclear receptor subfamily 1 group I member 2 Homo sapiens 195-200 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 nuclear receptor subfamily 1 group I member 3 Homo sapiens 202-207 31275424-6 2019 The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. caryophyllene 55-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 213-218 30836069-0 2019 beta-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 156-159 31109132-3 2019 This study was intended to discover the prospective cardioprotective actions of beta-caryophyllene, a natural sesquiterpene, to ameliorate isoproterenol (ISO)-induced myocardial infarction through HSP-60/TLR/MyD88/NFkappaB pathway. caryophyllene 80-98 heat shock protein family D (Hsp60) member 1 Homo sapiens 197-203 31109132-3 2019 This study was intended to discover the prospective cardioprotective actions of beta-caryophyllene, a natural sesquiterpene, to ameliorate isoproterenol (ISO)-induced myocardial infarction through HSP-60/TLR/MyD88/NFkappaB pathway. caryophyllene 80-98 MYD88 innate immune signal transduction adaptor Homo sapiens 208-213 31109132-3 2019 This study was intended to discover the prospective cardioprotective actions of beta-caryophyllene, a natural sesquiterpene, to ameliorate isoproterenol (ISO)-induced myocardial infarction through HSP-60/TLR/MyD88/NFkappaB pathway. caryophyllene 80-98 nuclear factor kappa B subunit 1 Homo sapiens 214-222 31109132-7 2019 On the other hand, consumption of beta-caryophyllene significantly reversed the infarcted size, ECG and BP alterations, ameliorated the ISO elevation in cardiac indicators; it also notably diminished HSP-60, and subsequently TLR2, TLR4, MYD88, and TRIF expression, with a substantial reduction in inflammatory mediator levels. caryophyllene 34-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 200-206 31109132-7 2019 On the other hand, consumption of beta-caryophyllene significantly reversed the infarcted size, ECG and BP alterations, ameliorated the ISO elevation in cardiac indicators; it also notably diminished HSP-60, and subsequently TLR2, TLR4, MYD88, and TRIF expression, with a substantial reduction in inflammatory mediator levels. caryophyllene 34-52 toll like receptor 2 Homo sapiens 225-229 31109132-7 2019 On the other hand, consumption of beta-caryophyllene significantly reversed the infarcted size, ECG and BP alterations, ameliorated the ISO elevation in cardiac indicators; it also notably diminished HSP-60, and subsequently TLR2, TLR4, MYD88, and TRIF expression, with a substantial reduction in inflammatory mediator levels. caryophyllene 34-52 toll like receptor 4 Homo sapiens 231-235 31109132-7 2019 On the other hand, consumption of beta-caryophyllene significantly reversed the infarcted size, ECG and BP alterations, ameliorated the ISO elevation in cardiac indicators; it also notably diminished HSP-60, and subsequently TLR2, TLR4, MYD88, and TRIF expression, with a substantial reduction in inflammatory mediator levels. caryophyllene 34-52 MYD88 innate immune signal transduction adaptor Homo sapiens 237-242 31109132-7 2019 On the other hand, consumption of beta-caryophyllene significantly reversed the infarcted size, ECG and BP alterations, ameliorated the ISO elevation in cardiac indicators; it also notably diminished HSP-60, and subsequently TLR2, TLR4, MYD88, and TRIF expression, with a substantial reduction in inflammatory mediator levels. caryophyllene 34-52 TIR domain containing adaptor molecule 1 Homo sapiens 248-252 31109132-8 2019 This study revealed the cardioprotective effect of beta-caryophyllene against MI through inhibiting HSP-60/TLR/MyD88/NFkappaB signaling pathways. caryophyllene 51-69 heat shock protein family D (Hsp60) member 1 Homo sapiens 100-106 31109132-8 2019 This study revealed the cardioprotective effect of beta-caryophyllene against MI through inhibiting HSP-60/TLR/MyD88/NFkappaB signaling pathways. caryophyllene 51-69 MYD88 innate immune signal transduction adaptor Homo sapiens 111-116 31109132-8 2019 This study revealed the cardioprotective effect of beta-caryophyllene against MI through inhibiting HSP-60/TLR/MyD88/NFkappaB signaling pathways. caryophyllene 51-69 nuclear factor kappa B subunit 1 Homo sapiens 117-125 30836069-6 2019 In the present study, we investigated the cardioprotective effect of a selective CB2 receptor agonist; beta-Caryophyllene (BCP), a natural bicyclic sesquiterpene, against DOX-induced chronic cardiotoxicity in rats. caryophyllene 103-121 cannabinoid receptor 2 Rattus norvegicus 81-84 30836069-7 2019 AM630, a CB2 receptor antagonist was administered as a pharmacological challenge prior to BCP treatment to demonstrate CB2 receptor mediated cardioprotective mechanism of BCP. caryophyllene 171-174 cannabinoid receptor 2 Rattus norvegicus 119-122 30836069-15 2019 The CB2 receptor-mediated cardioprotective mechanism was further confirmed by the abrogation of the beneficial effects of BCP with prior administration of the CB2 receptor antagonist; AM630. caryophyllene 122-125 cannabinoid receptor 2 Rattus norvegicus 4-7 30836069-15 2019 The CB2 receptor-mediated cardioprotective mechanism was further confirmed by the abrogation of the beneficial effects of BCP with prior administration of the CB2 receptor antagonist; AM630. caryophyllene 122-125 cannabinoid receptor 2 Rattus norvegicus 159-162 30836069-16 2019 Our study revealed the novel mechanism of BCP in cardioprotection against DOX-induced chronic cardiotoxicity by the activation of CB2 receptors. caryophyllene 42-45 cannabinoid receptor 2 Rattus norvegicus 130-133 31007758-2 2019 The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro. caryophyllene 99-117 tumor necrosis factor Mus musculus 173-182 31007758-2 2019 The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro. caryophyllene 99-117 interleukin 6 Mus musculus 184-188 31007758-2 2019 The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro. caryophyllene 99-117 interleukin 1 beta Mus musculus 193-201 30469079-0 2019 Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-gamma receptors. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 88-91 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 tachykinin 1 Mus musculus 0-11 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 interleukin 1 beta Mus musculus 34-51 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 interleukin 1 beta Mus musculus 53-61 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 tumor necrosis factor Mus musculus 64-91 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 tumor necrosis factor Mus musculus 93-102 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 interleukin 6 Mus musculus 109-122 30864870-11 2019 Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration. caryophyllene 156-159 interleukin 6 Mus musculus 124-128 30620895-3 2019 beta-Caryophyllene (BCP) is a dietary selective CB2 agonist, which deserves the anti-inflammatory and antioxidant effects at both low and high doses through activation of the CB2 receptor. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 48-51 30620895-3 2019 beta-Caryophyllene (BCP) is a dietary selective CB2 agonist, which deserves the anti-inflammatory and antioxidant effects at both low and high doses through activation of the CB2 receptor. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 175-178 30620895-3 2019 beta-Caryophyllene (BCP) is a dietary selective CB2 agonist, which deserves the anti-inflammatory and antioxidant effects at both low and high doses through activation of the CB2 receptor. caryophyllene 20-23 cannabinoid receptor 2 Homo sapiens 48-51 30620895-3 2019 beta-Caryophyllene (BCP) is a dietary selective CB2 agonist, which deserves the anti-inflammatory and antioxidant effects at both low and high doses through activation of the CB2 receptor. caryophyllene 20-23 cannabinoid receptor 2 Homo sapiens 175-178 30620895-5 2019 KEY FINDINGS: The protective effects of BCP on LPS-induced microglia imbalance is provided by the M2 healing phenotype of microglia, releasing the anti-inflammatory (IL-10, Arg-1, and urea) and anti-oxidant (GSH) parameters and reducing the inflammatory (IL-1beta, TNF-alpha, PGE2, iNOS and NO) and oxidative (ROS) biomarkers. caryophyllene 40-43 interleukin 10 Homo sapiens 166-171 30620895-5 2019 KEY FINDINGS: The protective effects of BCP on LPS-induced microglia imbalance is provided by the M2 healing phenotype of microglia, releasing the anti-inflammatory (IL-10, Arg-1, and urea) and anti-oxidant (GSH) parameters and reducing the inflammatory (IL-1beta, TNF-alpha, PGE2, iNOS and NO) and oxidative (ROS) biomarkers. caryophyllene 40-43 arginase 1 Homo sapiens 173-178 30620895-5 2019 KEY FINDINGS: The protective effects of BCP on LPS-induced microglia imbalance is provided by the M2 healing phenotype of microglia, releasing the anti-inflammatory (IL-10, Arg-1, and urea) and anti-oxidant (GSH) parameters and reducing the inflammatory (IL-1beta, TNF-alpha, PGE2, iNOS and NO) and oxidative (ROS) biomarkers. caryophyllene 40-43 interleukin 1 beta Homo sapiens 255-263 30620895-5 2019 KEY FINDINGS: The protective effects of BCP on LPS-induced microglia imbalance is provided by the M2 healing phenotype of microglia, releasing the anti-inflammatory (IL-10, Arg-1, and urea) and anti-oxidant (GSH) parameters and reducing the inflammatory (IL-1beta, TNF-alpha, PGE2, iNOS and NO) and oxidative (ROS) biomarkers. caryophyllene 40-43 tumor necrosis factor Homo sapiens 265-274 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 25-28 cannabinoid receptor 2 Homo sapiens 56-59 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 25-28 peroxisome proliferator activated receptor gamma Homo sapiens 230-240 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 151-154 cannabinoid receptor 2 Homo sapiens 56-59 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 151-154 peroxisome proliferator activated receptor gamma Homo sapiens 230-240 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 151-154 cannabinoid receptor 2 Homo sapiens 56-59 30620895-6 2019 Moreover, we showed that BCP exerts its effects through CB2 receptors which overproduction of ceramides by SMase at middle to higher concentrations of BCP reduce the protective activity of BCP and results in the activation of the PPAR-gamma pathway. caryophyllene 151-154 peroxisome proliferator activated receptor gamma Homo sapiens 230-240 30469079-0 2019 Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-gamma receptors. caryophyllene 0-18 peroxisome proliferator-activated receptor gamma Rattus norvegicus 96-106 30469079-2 2019 Beta-caryophyllene (BCP), a natural sesquiterpene, exerts neuroprotective, anxiolytic and antidepressant effects via its selective agonism to cannabinoid receptor 2 (CB2R). caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 142-164 30469079-2 2019 Beta-caryophyllene (BCP), a natural sesquiterpene, exerts neuroprotective, anxiolytic and antidepressant effects via its selective agonism to cannabinoid receptor 2 (CB2R). caryophyllene 20-23 cannabinoid receptor 2 Rattus norvegicus 142-164 30469079-11 2019 The anxiolytic, anti-oxidant and anti-inflammatory effects of BCP were mediated by both PPAR-gamma and CB2R. caryophyllene 62-65 peroxisome proliferator-activated receptor gamma Rattus norvegicus 88-98 30469079-13 2019 Furthermore, BCP-evoked antidepressant and memory improvement are likely mediated only via CB2R, mainly by upregulation of PGC-1alpha and BDNF. caryophyllene 13-16 PPARG coactivator 1 alpha Rattus norvegicus 123-133 30469079-13 2019 Furthermore, BCP-evoked antidepressant and memory improvement are likely mediated only via CB2R, mainly by upregulation of PGC-1alpha and BDNF. caryophyllene 13-16 brain-derived neurotrophic factor Rattus norvegicus 138-142 30469079-15 2019 BCP seems to activate PPAR-gamma in a ligand-independent manner, via upregulation and activation of PGC-1alpha. caryophyllene 0-3 peroxisome proliferator-activated receptor gamma Rattus norvegicus 22-32 30469079-15 2019 BCP seems to activate PPAR-gamma in a ligand-independent manner, via upregulation and activation of PGC-1alpha. caryophyllene 0-3 PPARG coactivator 1 alpha Rattus norvegicus 100-110 30469079-16 2019 The BCP activation of PPAR--gamma seems to be CB2R-dependent. caryophyllene 4-7 peroxisome proliferator-activated receptor gamma Rattus norvegicus 22-33 30343038-0 2019 Beta-caryophyllene protects against diet-induced dyslipidemia and vascular inflammation in rats: Involvement of CB2 and PPAR-gamma receptors. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 112-115 30343038-0 2019 Beta-caryophyllene protects against diet-induced dyslipidemia and vascular inflammation in rats: Involvement of CB2 and PPAR-gamma receptors. caryophyllene 0-18 peroxisome proliferator-activated receptor gamma Rattus norvegicus 120-130 30343038-1 2019 Beta-caryophyllene (BCP) is a phytocannabinoid possessing selective agonistic activity to cannabinoid type-2 receptors (CB2R) and peroxisome proliferator-activated receptors-alpha (PPAR-alpha). caryophyllene 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 181-191 30343038-2 2019 However, few studies reported the contribution of PPAR-gamma receptors in BCP effects. caryophyllene 74-77 peroxisome proliferator-activated receptor gamma Rattus norvegicus 50-60 30343038-1 2019 Beta-caryophyllene (BCP) is a phytocannabinoid possessing selective agonistic activity to cannabinoid type-2 receptors (CB2R) and peroxisome proliferator-activated receptors-alpha (PPAR-alpha). caryophyllene 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 181-191 30343038-8 2019 PPAR-gamma was involved in BCP-evoked suppression of vascular inflammation, VCAM-1 and restoration of normal vascular eNOS/iNOS balance thus normal NO level. caryophyllene 27-30 peroxisome proliferator-activated receptor gamma Rattus norvegicus 0-10 30132972-5 2018 beta-Caryophyllene, at the dose of 430 mg kg -1 , abolished the increases of protein carbonyl groups and myeloperoxidase activity in the liver and plasma of arthritic rats and, at both doses, it restored the increased levels of reactive oxygen species and reduced glutathione in the arthritic liver. caryophyllene 0-18 myeloperoxidase Rattus norvegicus 105-120 30343038-8 2019 PPAR-gamma was involved in BCP-evoked suppression of vascular inflammation, VCAM-1 and restoration of normal vascular eNOS/iNOS balance thus normal NO level. caryophyllene 27-30 vascular cell adhesion molecule 1 Rattus norvegicus 76-82 30343038-8 2019 PPAR-gamma was involved in BCP-evoked suppression of vascular inflammation, VCAM-1 and restoration of normal vascular eNOS/iNOS balance thus normal NO level. caryophyllene 27-30 nitric oxide synthase 2 Rattus norvegicus 123-127 30529211-4 2019 beta-Caryophyllene (BCP) is a selective type 2 cannabinoid (CB2) receptor agonist. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 60-63 30529211-4 2019 beta-Caryophyllene (BCP) is a selective type 2 cannabinoid (CB2) receptor agonist. caryophyllene 20-23 cannabinoid receptor 2 Homo sapiens 60-63 30529211-8 2019 BCP could prevent LPS-induced cytotoxicity and excessive production of NO, ROS, and TNF-alpha. caryophyllene 0-3 tumor necrosis factor Homo sapiens 84-93 30529211-9 2019 Also, we demonstrated that BCP"s protective effects against LPS-induced oligodendrocytes toxicity were mediated via the CB2 receptor through different pathways including Nrf2/HO-1/anti-oxidant axis, and PPAR-gamma, at low (0.2 and 1 microM), and high (10-50 microM) concentrations, respectively. caryophyllene 27-30 cannabinoid receptor 2 Homo sapiens 120-123 30529211-9 2019 Also, we demonstrated that BCP"s protective effects against LPS-induced oligodendrocytes toxicity were mediated via the CB2 receptor through different pathways including Nrf2/HO-1/anti-oxidant axis, and PPAR-gamma, at low (0.2 and 1 microM), and high (10-50 microM) concentrations, respectively. caryophyllene 27-30 NFE2 like bZIP transcription factor 2 Homo sapiens 170-174 30529211-9 2019 Also, we demonstrated that BCP"s protective effects against LPS-induced oligodendrocytes toxicity were mediated via the CB2 receptor through different pathways including Nrf2/HO-1/anti-oxidant axis, and PPAR-gamma, at low (0.2 and 1 microM), and high (10-50 microM) concentrations, respectively. caryophyllene 27-30 heme oxygenase 1 Homo sapiens 175-179 30529211-9 2019 Also, we demonstrated that BCP"s protective effects against LPS-induced oligodendrocytes toxicity were mediated via the CB2 receptor through different pathways including Nrf2/HO-1/anti-oxidant axis, and PPAR-gamma, at low (0.2 and 1 microM), and high (10-50 microM) concentrations, respectively. caryophyllene 27-30 peroxisome proliferator activated receptor gamma Homo sapiens 203-213 28107775-6 2018 RESULTS: Chronic treatment with BCP alleviated the chronic and binge alcohol-induced liver injury and inflammation by attenuating the pro-inflammatory phenotypic `M1` switch of Kupffer cells and by decreasing the expression of vascular adhesion molecules intercellular adhesion molecule 1, E-Selectin and P-Selectin, as well as the neutrophil infiltration. caryophyllene 32-35 selectin, endothelial cell Mus musculus 290-300 30026695-13 2018 Conclusion: The common food additive and CB2 agonist beta-caryophyllene might have the potential to attenuate dopaminergic firing, quenching the reward and thus motivation associated with romantic love. caryophyllene 53-71 cannabinoid receptor 2 Homo sapiens 41-44 29710667-10 2018 Moreover, our results indicated that BCP prevented MPP+-induced apoptosis of SH-SY5Y through inhibiting the up-regulation of cleaved Caspase-3, Bax, and restoring the expression of Bcl-2. caryophyllene 37-40 caspase 3 Homo sapiens 133-142 29710667-10 2018 Moreover, our results indicated that BCP prevented MPP+-induced apoptosis of SH-SY5Y through inhibiting the up-regulation of cleaved Caspase-3, Bax, and restoring the expression of Bcl-2. caryophyllene 37-40 BCL2 associated X, apoptosis regulator Homo sapiens 144-147 29710667-10 2018 Moreover, our results indicated that BCP prevented MPP+-induced apoptosis of SH-SY5Y through inhibiting the up-regulation of cleaved Caspase-3, Bax, and restoring the expression of Bcl-2. caryophyllene 37-40 BCL2 apoptosis regulator Homo sapiens 181-186 29710667-11 2018 Besides, BCP markedly suppressed HO-1 activation and c-Jun N-terminal Kinase (JNK) phosphorylation. caryophyllene 9-12 mitogen-activated protein kinase 8 Homo sapiens 53-76 29710667-11 2018 Besides, BCP markedly suppressed HO-1 activation and c-Jun N-terminal Kinase (JNK) phosphorylation. caryophyllene 9-12 mitogen-activated protein kinase 8 Homo sapiens 78-81 29748726-9 2018 Docking studies show that all molecules tested have the ability to interact with the SCP-2 protein, wherein alpha-humulene and beta-caryophyllene were the compounds with higher binding energy. caryophyllene 127-145 uncharacterized protein LOC6048170 Culex quinquefasciatus 85-90 29547827-0 2018 Pharmacological characterization of the cannabinoid receptor 2 agonist, beta-caryophyllene on seizure models in mice. caryophyllene 72-90 cannabinoid receptor 2 (macrophage) Mus musculus 40-62 29547827-3 2018 The aim of the present study was to explore the effect of a selective CB2 receptor agonist beta-caryophyllene (BCP) in models of seizures and cognition in mice. caryophyllene 91-109 cannabinoid receptor 2 (macrophage) Mus musculus 70-73 29547827-3 2018 The aim of the present study was to explore the effect of a selective CB2 receptor agonist beta-caryophyllene (BCP) in models of seizures and cognition in mice. caryophyllene 111-114 cannabinoid receptor 2 (macrophage) Mus musculus 70-73 29402275-7 2018 In the frontal cortex, BCP further prevented activation of the endocannabinoid system (ECS), spared the docosahexaenoic acid (DHA), appeared to prevent the increase of cyclooxygenase-2 and increased the peroxisome-proliferator activated receptor-alpha (PPAR-alpha) protein levels, while, in plasma, BCP induced the reduction of arachidonoylethanolamide (AEA) levels as compared to vehicle-treated rats. caryophyllene 23-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 168-184 29402275-7 2018 In the frontal cortex, BCP further prevented activation of the endocannabinoid system (ECS), spared the docosahexaenoic acid (DHA), appeared to prevent the increase of cyclooxygenase-2 and increased the peroxisome-proliferator activated receptor-alpha (PPAR-alpha) protein levels, while, in plasma, BCP induced the reduction of arachidonoylethanolamide (AEA) levels as compared to vehicle-treated rats. caryophyllene 23-26 peroxisome proliferator activated receptor alpha Rattus norvegicus 203-251 29402275-7 2018 In the frontal cortex, BCP further prevented activation of the endocannabinoid system (ECS), spared the docosahexaenoic acid (DHA), appeared to prevent the increase of cyclooxygenase-2 and increased the peroxisome-proliferator activated receptor-alpha (PPAR-alpha) protein levels, while, in plasma, BCP induced the reduction of arachidonoylethanolamide (AEA) levels as compared to vehicle-treated rats. caryophyllene 23-26 peroxisome proliferator activated receptor alpha Rattus norvegicus 253-263 29402275-8 2018 CONCLUSIONS: Collectively, the pre-treatment with BCP, likely acting as agonist for CB2 and PPAR-alpha receptors, modulates in a beneficial way the ECS activation and the lipoperoxidation, taken as indicative of oxidative stress. caryophyllene 50-53 cannabinoid receptor 2 Rattus norvegicus 84-87 29402275-8 2018 CONCLUSIONS: Collectively, the pre-treatment with BCP, likely acting as agonist for CB2 and PPAR-alpha receptors, modulates in a beneficial way the ECS activation and the lipoperoxidation, taken as indicative of oxidative stress. caryophyllene 50-53 peroxisome proliferator activated receptor alpha Rattus norvegicus 92-102 28107775-6 2018 RESULTS: Chronic treatment with BCP alleviated the chronic and binge alcohol-induced liver injury and inflammation by attenuating the pro-inflammatory phenotypic `M1` switch of Kupffer cells and by decreasing the expression of vascular adhesion molecules intercellular adhesion molecule 1, E-Selectin and P-Selectin, as well as the neutrophil infiltration. caryophyllene 32-35 selectin, platelet Mus musculus 305-315 28107775-8 2018 These protective effects of BCP against alcohol-induced liver injury were attenuated in CB2 receptor knockout mice, indicating that the beneficial effects of this natural product in liver injury involve activation of these receptors. caryophyllene 28-31 cannabinoid receptor 2 (macrophage) Mus musculus 88-91 28821008-0 2017 Trans-caryophyllene inhibits amyloid beta (Abeta) oligomer-induced neuroinflammation in BV-2 microglial cells. caryophyllene 0-19 amyloid beta precursor protein Homo sapiens 29-41 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 high mobility group box 1 Mus musculus 19-44 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 high mobility group box 1 Mus musculus 46-51 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 toll-like receptor 4 Mus musculus 54-74 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 toll-like receptor 4 Mus musculus 76-80 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 interleukin 1 beta Mus musculus 83-100 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 interleukin 1 beta Mus musculus 102-110 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 tumor necrosis factor Mus musculus 117-144 29123466-11 2017 BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. caryophyllene 0-3 tumor necrosis factor Mus musculus 146-155 28821008-0 2017 Trans-caryophyllene inhibits amyloid beta (Abeta) oligomer-induced neuroinflammation in BV-2 microglial cells. caryophyllene 0-19 amyloid beta (A4) precursor protein Mus musculus 43-48 28821008-6 2017 In addition, pretreatment of BV2 microglia with TC at concentrations of 10, 25, and 50muM prior to Abeta stimulation led to significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and secretion of pro-inflammatory cytokines. caryophyllene 48-50 nitric oxide synthase 2, inducible Mus musculus 222-253 28821008-6 2017 In addition, pretreatment of BV2 microglia with TC at concentrations of 10, 25, and 50muM prior to Abeta stimulation led to significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and secretion of pro-inflammatory cytokines. caryophyllene 48-50 nitric oxide synthase 2, inducible Mus musculus 255-259 28821008-6 2017 In addition, pretreatment of BV2 microglia with TC at concentrations of 10, 25, and 50muM prior to Abeta stimulation led to significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and secretion of pro-inflammatory cytokines. caryophyllene 48-50 prostaglandin-endoperoxide synthase 2 Mus musculus 265-281 28821008-6 2017 In addition, pretreatment of BV2 microglia with TC at concentrations of 10, 25, and 50muM prior to Abeta stimulation led to significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and secretion of pro-inflammatory cytokines. caryophyllene 48-50 prostaglandin-endoperoxide synthase 2 Mus musculus 283-288 28821008-7 2017 Notably, our results indicate that TC remarkably attenuated Abeta1-42-activated overexpression of toll-like receptor 4 (TLR4). caryophyllene 35-37 toll-like receptor 4 Mus musculus 98-118 28821008-7 2017 Notably, our results indicate that TC remarkably attenuated Abeta1-42-activated overexpression of toll-like receptor 4 (TLR4). caryophyllene 35-37 toll-like receptor 4 Mus musculus 120-124 28821008-8 2017 We further demonstrated that TC markedly reversed Abeta1-42-induced phosphorylation and degradation of IkappaBalpha, nuclear translocation of p65, and NF-kappaB transcriptional activity. caryophyllene 29-31 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 103-115 28821008-8 2017 We further demonstrated that TC markedly reversed Abeta1-42-induced phosphorylation and degradation of IkappaBalpha, nuclear translocation of p65, and NF-kappaB transcriptional activity. caryophyllene 29-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 28729222-9 2017 BCP attenuated the established mechanical allodynia induced by PTX (p < 0.0001) in a CB2-dependent manner. caryophyllene 0-3 cannabinoid receptor 2 (macrophage) Mus musculus 88-91 28729222-11 2017 Spinal cord immunohistochemistry revealed that preventive treatment with BCP reduced p38 MAPK and NF-kappaB activation, as well as the increased Iba-1 and IL-1beta immunoreactivity promoted by PTX. caryophyllene 73-76 mitogen-activated protein kinase 14 Mus musculus 85-93 28729222-11 2017 Spinal cord immunohistochemistry revealed that preventive treatment with BCP reduced p38 MAPK and NF-kappaB activation, as well as the increased Iba-1 and IL-1beta immunoreactivity promoted by PTX. caryophyllene 73-76 induction of brown adipocytes 1 Mus musculus 145-150 28729222-11 2017 Spinal cord immunohistochemistry revealed that preventive treatment with BCP reduced p38 MAPK and NF-kappaB activation, as well as the increased Iba-1 and IL-1beta immunoreactivity promoted by PTX. caryophyllene 73-76 interleukin 1 beta Mus musculus 155-163 28729222-12 2017 Our findings show that BCP effectively attenuated PINP, possibly through CB2-activation in the CNS and posterior inhibition of p38 MAPK/NF-kappaB activation and cytokine release. caryophyllene 23-26 cannabinoid receptor 2 (macrophage) Mus musculus 73-76 28729222-12 2017 Our findings show that BCP effectively attenuated PINP, possibly through CB2-activation in the CNS and posterior inhibition of p38 MAPK/NF-kappaB activation and cytokine release. caryophyllene 23-26 mitogen-activated protein kinase 14 Mus musculus 127-135 28624443-6 2017 Importantly, administration of TC could inhibit the induction of vascular cell adhesion molecule-1 (VCAM-1) both in vitro and in vivo. caryophyllene 31-33 vascular cell adhesion molecule 1 Homo sapiens 100-106 28624443-7 2017 Notably, our data indicate that the inhibitory effects of TC on the expression of VCAM-1 are mediated by the JAK2/STAT1/IRF-1 pathway. caryophyllene 58-60 vascular cell adhesion molecule 1 Homo sapiens 82-88 28624443-6 2017 Importantly, administration of TC could inhibit the induction of vascular cell adhesion molecule-1 (VCAM-1) both in vitro and in vivo. caryophyllene 31-33 vascular cell adhesion molecule 1 Homo sapiens 65-98 28624443-7 2017 Notably, our data indicate that the inhibitory effects of TC on the expression of VCAM-1 are mediated by the JAK2/STAT1/IRF-1 pathway. caryophyllene 58-60 Janus kinase 2 Homo sapiens 109-113 28624443-7 2017 Notably, our data indicate that the inhibitory effects of TC on the expression of VCAM-1 are mediated by the JAK2/STAT1/IRF-1 pathway. caryophyllene 58-60 signal transducer and activator of transcription 1 Homo sapiens 114-119 28624443-7 2017 Notably, our data indicate that the inhibitory effects of TC on the expression of VCAM-1 are mediated by the JAK2/STAT1/IRF-1 pathway. caryophyllene 58-60 interferon regulatory factor 1 Homo sapiens 120-125 28624443-8 2017 TC is a specific agonist of the type 2 cannabinoid receptor (CB2R). caryophyllene 0-2 cannabinoid receptor 2 Homo sapiens 61-64 28624443-9 2017 Importantly, we further verified that the inhibitory effects of TC on the expression of IRF-1 and VCAM-1 are dependent on activation of CB2R. caryophyllene 64-66 interferon regulatory factor 1 Homo sapiens 88-93 28624443-9 2017 Importantly, we further verified that the inhibitory effects of TC on the expression of IRF-1 and VCAM-1 are dependent on activation of CB2R. caryophyllene 64-66 vascular cell adhesion molecule 1 Homo sapiens 98-104 28624443-10 2017 Inhibition of CB2R by either specific inhibitors or RNA interference abolished the inhibitory effects of TC on the expression of IRF-1 and VCAM-1. caryophyllene 105-107 interferon regulatory factor 1 Homo sapiens 129-134 28624443-10 2017 Inhibition of CB2R by either specific inhibitors or RNA interference abolished the inhibitory effects of TC on the expression of IRF-1 and VCAM-1. caryophyllene 105-107 vascular cell adhesion molecule 1 Homo sapiens 139-145 28428873-4 2017 The (E)-caryophyllene production level and transcript abundance of TPS23, terpene synthase responsible for (E)-caryophyllene formation, were compared between Braz1006, Delprim, and B73 after mimicked herbivory. caryophyllene 107-124 (E)-beta-caryophyllene synthase Zea mays 67-72 28463791-7 2017 BCP (25 and 50mg/kg/day) reduced clinical score and severity of EAE and inhibited H2O2, NO, TNF-alpha, IFN-gamma and, IL-17 production. caryophyllene 0-3 tumor necrosis factor Mus musculus 92-101 28463791-7 2017 BCP (25 and 50mg/kg/day) reduced clinical score and severity of EAE and inhibited H2O2, NO, TNF-alpha, IFN-gamma and, IL-17 production. caryophyllene 0-3 interferon gamma Mus musculus 103-112 28463791-7 2017 BCP (25 and 50mg/kg/day) reduced clinical score and severity of EAE and inhibited H2O2, NO, TNF-alpha, IFN-gamma and, IL-17 production. caryophyllene 0-3 interleukin 17A Mus musculus 118-123 28236211-0 2017 beta-Caryophyllene Pretreatment Alleviates Focal Cerebral Ischemia-Reperfusion Injury by Activating PI3K/Akt Signaling Pathway. caryophyllene 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 28236211-8 2017 Our results suggested that BCP pre-treatment protects against I/R injury partly by suppressing apoptosis via PI3K/AKt signaling pathway activation. caryophyllene 27-30 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 28368293-0 2017 (-)-beta-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. caryophyllene 0-22 cannabinoid receptor 2 (macrophage) Mus musculus 26-29 28368293-1 2017 (-)-beta-caryophyllene (BCP), a cannabinoid receptor type 2 (CB2)-selective phytocannabinoid, has already been shown in precedent literature to exhibit both anti-inflammatory and analgesic effects in mouse models of inflammatory and neuropathic pain. caryophyllene 0-22 cannabinoid receptor 2 (macrophage) Mus musculus 61-64 28368293-1 2017 (-)-beta-caryophyllene (BCP), a cannabinoid receptor type 2 (CB2)-selective phytocannabinoid, has already been shown in precedent literature to exhibit both anti-inflammatory and analgesic effects in mouse models of inflammatory and neuropathic pain. caryophyllene 24-27 cannabinoid receptor 2 (macrophage) Mus musculus 61-64 28684694-4 2017 beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R). caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 87-114 28684694-4 2017 beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R). caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 116-120 28684694-4 2017 beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R). caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 87-114 28684694-4 2017 beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R). caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 116-120 28428873-8 2017 The superior (E)-caryophyllene production by Braz1006 was positively correlated with high transcript levels of TPS23 in the landrace compared to Delprim. caryophyllene 13-30 (E)-beta-caryophyllene synthase Zea mays 111-116 28428873-11 2017 The variation in (E)-caryophyllene emission between Braz1006 and Delprim is positively correlated with induced levels of TPS23 transcripts. caryophyllene 17-34 (E)-beta-caryophyllene synthase Zea mays 121-126 27565895-8 2016 BCP pre-treatment prior to the initiation of OGD/R significantly (i) decreased BBB permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated Bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, ZO-1, growth-associated protein-43 and Bcl-2 expression. caryophyllene 0-3 BCL2 associated X, apoptosis regulator Homo sapiens 223-226 27871898-1 2017 Beta-caryophyllene (BCP) is a phytocannabinoid whose neuroprotective activity has been mainly associated with selective activation of cannabinoid-type-2 (CB2) receptors, inhibition of microglial activation and decrease of inflammation. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 154-157 27871898-1 2017 Beta-caryophyllene (BCP) is a phytocannabinoid whose neuroprotective activity has been mainly associated with selective activation of cannabinoid-type-2 (CB2) receptors, inhibition of microglial activation and decrease of inflammation. caryophyllene 20-23 cannabinoid receptor 2 Rattus norvegicus 154-157 27871898-3 2017 We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself. caryophyllene 21-24 nerve growth factor Rattus norvegicus 66-69 27871898-3 2017 We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself. caryophyllene 21-24 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 88-92 27871898-3 2017 We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself. caryophyllene 21-24 nerve growth factor Rattus norvegicus 96-99 27871898-3 2017 We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself. caryophyllene 21-24 nerve growth factor Rattus norvegicus 96-99 27871898-4 2017 The neuritogenic effect of BCP in PC12 cells was abolished by k252a, an inhibitor of the NGF-specific receptor trkA. caryophyllene 27-30 nerve growth factor Rattus norvegicus 89-92 27871898-4 2017 The neuritogenic effect of BCP in PC12 cells was abolished by k252a, an inhibitor of the NGF-specific receptor trkA. caryophyllene 27-30 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 111-115 27871898-6 2017 Additionally, we demonstrated that BCP increases the expression of axonal-plasticity-associated proteins (GAP-43, synapsin and synaptophysin) in PC12 cells. caryophyllene 35-38 growth associated protein 43 Rattus norvegicus 106-112 27871898-6 2017 Additionally, we demonstrated that BCP increases the expression of axonal-plasticity-associated proteins (GAP-43, synapsin and synaptophysin) in PC12 cells. caryophyllene 35-38 synaptophysin Rattus norvegicus 127-140 27871898-8 2017 Altogether, these findings suggest that BCP activates trka receptors and induces neuritogenesis by a mechanism independent of NGF or cannabinoid receptors. caryophyllene 40-43 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 54-58 27871898-8 2017 Altogether, these findings suggest that BCP activates trka receptors and induces neuritogenesis by a mechanism independent of NGF or cannabinoid receptors. caryophyllene 40-43 nerve growth factor Rattus norvegicus 126-129 28026135-4 2017 The results indicate that TC caused a significant elevation in collagen content, alkaline phosphatase activity, osteocalcin production, and mineralization, which are the four markers that account for the various stages of osteoblastic differentiation. caryophyllene 26-28 bone gamma-carboxyglutamate protein 2 Mus musculus 112-123 28026135-6 2017 TC has been shown to be an agonist of the cannabinoid type 2 receptor (CB2R), and the effects of TC on osteocalcin secretion and matrix mineralization were abolished in MC3T3E1 cells transfected with CB2R siRNA. caryophyllene 0-2 cannabinoid receptor 2 (macrophage) Mus musculus 42-69 28026135-6 2017 TC has been shown to be an agonist of the cannabinoid type 2 receptor (CB2R), and the effects of TC on osteocalcin secretion and matrix mineralization were abolished in MC3T3E1 cells transfected with CB2R siRNA. caryophyllene 0-2 cannabinoid receptor 2 (macrophage) Mus musculus 71-75 28026135-6 2017 TC has been shown to be an agonist of the cannabinoid type 2 receptor (CB2R), and the effects of TC on osteocalcin secretion and matrix mineralization were abolished in MC3T3E1 cells transfected with CB2R siRNA. caryophyllene 0-2 cannabinoid receptor 2 (macrophage) Mus musculus 200-204 28026135-6 2017 TC has been shown to be an agonist of the cannabinoid type 2 receptor (CB2R), and the effects of TC on osteocalcin secretion and matrix mineralization were abolished in MC3T3E1 cells transfected with CB2R siRNA. caryophyllene 97-99 bone gamma-carboxyglutamate protein 2 Mus musculus 103-114 28026135-6 2017 TC has been shown to be an agonist of the cannabinoid type 2 receptor (CB2R), and the effects of TC on osteocalcin secretion and matrix mineralization were abolished in MC3T3E1 cells transfected with CB2R siRNA. caryophyllene 97-99 cannabinoid receptor 2 (macrophage) Mus musculus 200-204 28026135-7 2017 Our findings that TC promotes the formation of a mineralized extracellular matrix help to elucidate the role of CB2 signaling in the formation of bone and the maintenance of normal bone mass. caryophyllene 18-20 cannabinoid receptor 2 (macrophage) Mus musculus 112-115 27565895-8 2016 BCP pre-treatment prior to the initiation of OGD/R significantly (i) decreased BBB permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated Bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, ZO-1, growth-associated protein-43 and Bcl-2 expression. caryophyllene 0-3 claudin 5 Homo sapiens 306-315 27565895-8 2016 BCP pre-treatment prior to the initiation of OGD/R significantly (i) decreased BBB permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated Bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, ZO-1, growth-associated protein-43 and Bcl-2 expression. caryophyllene 0-3 occludin Homo sapiens 317-325 27565895-8 2016 BCP pre-treatment prior to the initiation of OGD/R significantly (i) decreased BBB permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated Bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, ZO-1, growth-associated protein-43 and Bcl-2 expression. caryophyllene 0-3 tight junction protein 1 Homo sapiens 327-361 27565895-8 2016 BCP pre-treatment prior to the initiation of OGD/R significantly (i) decreased BBB permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated Bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, ZO-1, growth-associated protein-43 and Bcl-2 expression. caryophyllene 0-3 BCL2 apoptosis regulator Homo sapiens 366-371 27531971-12 2016 Interestingly, BCP supplementation demonstrated the potent therapeutic effects against ROT-induced neurodegeneration, which was evidenced by BCP-mediated CB2 receptor activation and the fact that, prior administration of the CB2 receptor antagonist AM630 diminished the beneficial effects of BCP. caryophyllene 15-18 cannabinoid receptor 2 Rattus norvegicus 154-157 27234712-0 2016 beta-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 104-107 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 sterol regulatory element binding transcription factor 1 Homo sapiens 75-119 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 sterol regulatory element binding transcription factor 1 Homo sapiens 121-129 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 forkhead box O1 Homo sapiens 152-175 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 forkhead box O1 Homo sapiens 177-182 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 fatty acid synthase Homo sapiens 285-304 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 fatty acid synthase Homo sapiens 306-309 27234712-5 2016 Our data also showed that beta-caryophyllene prevents the translocation of sterol regulatory element-binding protein-1c (SREBP-1c) into the nucleus and forkhead box protein O1 (FoxO1) into the cytoplasm through AMPK signaling, and consequently, induces a significant downregulation of fatty acid synthase (FAS) and upregulation of adipose triglyceride lipase, respectively. caryophyllene 26-44 patatin like phospholipase domain containing 2 Homo sapiens 331-358 27531971-4 2016 In the present study, we investigated the CB2 receptor-mediated neuroprotective effect of beta-caryophyllene (BCP), a naturally occurring CB2 receptor agonist, in, a clinically relevant, rotenone (ROT)-induced animal model of PD. caryophyllene 90-108 cannabinoid receptor 2 Rattus norvegicus 42-45 27531971-4 2016 In the present study, we investigated the CB2 receptor-mediated neuroprotective effect of beta-caryophyllene (BCP), a naturally occurring CB2 receptor agonist, in, a clinically relevant, rotenone (ROT)-induced animal model of PD. caryophyllene 110-113 cannabinoid receptor 2 Rattus norvegicus 42-45 27531971-12 2016 Interestingly, BCP supplementation demonstrated the potent therapeutic effects against ROT-induced neurodegeneration, which was evidenced by BCP-mediated CB2 receptor activation and the fact that, prior administration of the CB2 receptor antagonist AM630 diminished the beneficial effects of BCP. caryophyllene 15-18 cannabinoid receptor 2 Rattus norvegicus 225-228 27531971-12 2016 Interestingly, BCP supplementation demonstrated the potent therapeutic effects against ROT-induced neurodegeneration, which was evidenced by BCP-mediated CB2 receptor activation and the fact that, prior administration of the CB2 receptor antagonist AM630 diminished the beneficial effects of BCP. caryophyllene 141-144 cannabinoid receptor 2 Rattus norvegicus 154-157 27531971-12 2016 Interestingly, BCP supplementation demonstrated the potent therapeutic effects against ROT-induced neurodegeneration, which was evidenced by BCP-mediated CB2 receptor activation and the fact that, prior administration of the CB2 receptor antagonist AM630 diminished the beneficial effects of BCP. caryophyllene 141-144 cannabinoid receptor 2 Rattus norvegicus 154-157 27531971-13 2016 The present study suggests that BCP has the potential therapeutic efficacy to elicit significant neuroprotection by its anti-inflammatory and antioxidant activities mediated by activation of the CB2 receptors. caryophyllene 32-35 cannabinoid receptor 2 Rattus norvegicus 195-198 26883973-0 2016 beta-caryophyllene, a dietary cannabinoid, complexed with beta-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn. caryophyllene 0-18 FBJ osteosarcoma oncogene Mus musculus 138-141 27316720-7 2016 However, treatment with BCP rescued dopaminergic neurons and decreased microglia and astrocyte activation evidenced by reduced Iba-1 and GFAP expression. caryophyllene 24-27 allograft inflammatory factor 1 Rattus norvegicus 127-132 27316720-7 2016 However, treatment with BCP rescued dopaminergic neurons and decreased microglia and astrocyte activation evidenced by reduced Iba-1 and GFAP expression. caryophyllene 24-27 glial fibrillary acidic protein Rattus norvegicus 137-141 27316720-8 2016 BCP in addition to attenuation of pro-inflammatory cytokines and inflammatory mediators such as COX-2 and iNOS, also restored antioxidant enzymes and inhibited lipid peroxidation as well as glutathione depletion. caryophyllene 0-3 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 96-101 27316720-8 2016 BCP in addition to attenuation of pro-inflammatory cytokines and inflammatory mediators such as COX-2 and iNOS, also restored antioxidant enzymes and inhibited lipid peroxidation as well as glutathione depletion. caryophyllene 0-3 nitric oxide synthase 2 Rattus norvegicus 106-110 26801169-0 2016 beta-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats. caryophyllene 0-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 76-80 26801169-0 2016 beta-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 81-85 26801169-11 2016 And the protein and mRNA expressions of Nrf2 and HO-1 were significantly up-regulated in the BCP pretreated I-R group. caryophyllene 93-96 NFE2 like bZIP transcription factor 2 Rattus norvegicus 40-44 26801169-11 2016 And the protein and mRNA expressions of Nrf2 and HO-1 were significantly up-regulated in the BCP pretreated I-R group. caryophyllene 93-96 heme oxygenase 1 Rattus norvegicus 49-53 26801169-13 2016 All the above suggested that BCP pretreatment played a neuroprotective role in cerebral I-R injury, which might be exerted by upregulating the expression of Nrf2 and HO-1 to ameliorate oxidative damage and neuronal apoptosis. caryophyllene 29-32 NFE2 like bZIP transcription factor 2 Rattus norvegicus 157-161 26801169-13 2016 All the above suggested that BCP pretreatment played a neuroprotective role in cerebral I-R injury, which might be exerted by upregulating the expression of Nrf2 and HO-1 to ameliorate oxidative damage and neuronal apoptosis. caryophyllene 29-32 heme oxygenase 1 Rattus norvegicus 166-170 25355059-5 2014 In Arabidopsis thaliana, the miR156-SPL module regulates the formation of (E)-beta-caryophyllene in flowering stage through modulating expression of the sesquiterpene synthase gene TPS21. caryophyllene 74-96 terpene synthase 21 Arabidopsis thaliana 181-186 26965491-4 2016 RESULTS: BCP was found to elicit a full agonist action on cannabinoid type 2 (CB2) receptors, a G-protein coupled receptor representing important therapeutic target in several diseases. caryophyllene 9-12 cannabinoid receptor 2 Homo sapiens 78-81 26025912-8 2015 HFD feeding increased the levels of CCL19 and CCL21 in the LN and the expression of CCR7 in the tumor; these changes were blocked by dietary BCP. caryophyllene 141-144 chemokine (C-C motif) ligand 19 Mus musculus 36-41 26025912-8 2015 HFD feeding increased the levels of CCL19 and CCL21 in the LN and the expression of CCR7 in the tumor; these changes were blocked by dietary BCP. caryophyllene 141-144 chemokine (C-C motif) receptor 7 Mus musculus 84-88 26025912-9 2015 In vitro culture results revealed that BCP inhibited lipid accumulation in 3T3-L1 preadipocytes; monocyte migration and monocyte chemoattractant protein-1 secretion by B16F10s, adipocytes and M2-MPhis; angiogenesis and lymphangiogenesis. caryophyllene 39-42 chemokine (C-C motif) ligand 2 Mus musculus 120-154 26025912-10 2015 The suppression of adipocyte and M2-cell accumulation and the inhibition of CCL19/21-CCR7 axis may be a part of mechanisms for the BCP suppression of HFD-stimulated melanoma progression. caryophyllene 131-134 chemokine (C-C motif) ligand 19 Mus musculus 76-81 26025912-10 2015 The suppression of adipocyte and M2-cell accumulation and the inhibition of CCL19/21-CCR7 axis may be a part of mechanisms for the BCP suppression of HFD-stimulated melanoma progression. caryophyllene 131-134 chemokine (C-C motif) receptor 7 Mus musculus 85-89 25578275-5 2015 In Arabidopsis thaliana, the miR156-SPL module regulates the formation of (E)-beta-caryophyllene in the flowering stage through modulating expression of the sesquiterpene synthase gene TPS21. caryophyllene 74-96 terpene synthase 21 Arabidopsis thaliana 185-190 25417010-7 2015 TC pretreatment also preserved the activity of GPx, SOD, and CAT. caryophyllene 0-2 catalase Mus musculus 61-64 25417010-8 2015 Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-alpha and IL-1beta. caryophyllene 54-56 tumor necrosis factor Mus musculus 184-193 25417010-8 2015 Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-alpha and IL-1beta. caryophyllene 54-56 interleukin 1 beta Mus musculus 198-206 25179573-6 2014 However, fibrotic rats treated with either beta-caryophyllene or hemopressin had reduced hepatic collagen content, improved transaminase activity and reduced bilirubin level, ameliorated CB1 gene expression, and increased MMP-1 gene expression compared with untreated fibrotic rats. caryophyllene 43-61 cannabinoid receptor 1 Rattus norvegicus 187-190 25179573-6 2014 However, fibrotic rats treated with either beta-caryophyllene or hemopressin had reduced hepatic collagen content, improved transaminase activity and reduced bilirubin level, ameliorated CB1 gene expression, and increased MMP-1 gene expression compared with untreated fibrotic rats. caryophyllene 43-61 matrix metallopeptidase 1 Rattus norvegicus 222-227 25179573-8 2014 CB2 receptor blockade by AM630 prevents the effects of beta-caryophyllene on CB1 receptor and MMP-1 genes expression. caryophyllene 55-73 cannabinoid receptor 2 Rattus norvegicus 0-3 25179573-8 2014 CB2 receptor blockade by AM630 prevents the effects of beta-caryophyllene on CB1 receptor and MMP-1 genes expression. caryophyllene 55-73 cannabinoid receptor 1 Rattus norvegicus 77-80 25179573-8 2014 CB2 receptor blockade by AM630 prevents the effects of beta-caryophyllene on CB1 receptor and MMP-1 genes expression. caryophyllene 55-73 matrix metallopeptidase 1 Rattus norvegicus 94-99 24831513-1 2014 The widespread dietary plant sesquiterpene hydrocarbon beta-caryophyllene (1) is a CB2 cannabinoid receptor-specific agonist showing anti-inflammatory and analgesic effects in vivo. caryophyllene 55-73 cannabinoid receptor 2 Homo sapiens 83-86 25194788-0 2014 beta-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway. caryophyllene 0-18 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 25194788-6 2014 Moreover, BCP per se induced the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which was reflected by improvement in the cellular GSH antioxidant system. caryophyllene 10-13 NFE2 like bZIP transcription factor 2 Homo sapiens 58-101 25194788-6 2014 Moreover, BCP per se induced the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which was reflected by improvement in the cellular GSH antioxidant system. caryophyllene 10-13 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 25194788-7 2014 Taken together, our results suggest that cytoprotective effects of BCP were mediated by the amelioration of cellular antioxidant responses via Nrf2 activation, which is, in part, dependent on cannabinoid receptor type 2 (CB2R) activation. caryophyllene 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 143-147 25229208-1 2014 The secondary organic aerosol (SOA) mass yields from NO3 oxidation of a series of biogenic volatile organic compounds (BVOCs), consisting of five monoterpenes and one sesquiterpene (alpha-pinene, beta-pinene, Delta-3-carene, limonene, sabinene, and beta-caryophyllene), were investigated in a series of continuous flow experiments in a 10 m(3) indoor Teflon chamber. caryophyllene 249-267 NBL1, DAN family BMP antagonist Homo sapiens 53-56 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 90-93 Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 Caenorhabditis elegans 172-179 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 90-93 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 181-186 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 90-93 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 191-197 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 133-136 Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 Caenorhabditis elegans 172-179 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 133-136 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 181-186 24835194-8 2014 In the present investigation, we have predicted possible biological molecular targets for BCP using molecular docking approaches and BCP was found to have interaction with SIR-2.1, SKN-1 and DAF-16. caryophyllene 133-136 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 191-197 24835194-10 2014 It was observed that BCP increased lifespan of mev-1 and daf-16 but failed to augment lifespan in eat-2, sir-2.1 and skn-1 mutants. caryophyllene 21-24 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Caenorhabditis elegans 47-52 24835194-10 2014 It was observed that BCP increased lifespan of mev-1 and daf-16 but failed to augment lifespan in eat-2, sir-2.1 and skn-1 mutants. caryophyllene 21-24 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 57-63 24488604-0 2014 Trans-caryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-kappaB activation in microglia. caryophyllene 0-19 nuclear factor kappa B subunit 1 Homo sapiens 89-98 24488604-2 2014 Given the fact that the activation of the type 2 cannabinoid receptor (CB2R) provides antioxidative and anti-inflammatory results, it is suspected that its selective agonist, trans-caryophyllene (TC), may have protective effects against hypoxia-induced neuroinflammatory responses. caryophyllene 175-194 cannabinoid receptor 2 Homo sapiens 71-74 24488604-2 2014 Given the fact that the activation of the type 2 cannabinoid receptor (CB2R) provides antioxidative and anti-inflammatory results, it is suspected that its selective agonist, trans-caryophyllene (TC), may have protective effects against hypoxia-induced neuroinflammatory responses. caryophyllene 196-198 cannabinoid receptor 2 Homo sapiens 71-74 24488604-3 2014 In this study, TC was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). caryophyllene 15-17 interleukin 1 beta Homo sapiens 145-153 24488604-3 2014 In this study, TC was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). caryophyllene 15-17 tumor necrosis factor Homo sapiens 155-164 24488604-3 2014 In this study, TC was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). caryophyllene 15-17 interleukin 6 Homo sapiens 170-174 24488604-4 2014 Furthermore, TC significantly inhibited hypoxia-induced generation of reactive oxygen species (ROS) in mitochondria as well as the activation of nuclear factor kappa B (NF-kappaB) in microglia. caryophyllene 13-15 nuclear factor kappa B subunit 1 Homo sapiens 145-167 24488604-4 2014 Furthermore, TC significantly inhibited hypoxia-induced generation of reactive oxygen species (ROS) in mitochondria as well as the activation of nuclear factor kappa B (NF-kappaB) in microglia. caryophyllene 13-15 nuclear factor kappa B subunit 1 Homo sapiens 169-178 24488604-6 2014 These observations indicate that TC suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-kappaB activation in microglia. caryophyllene 33-35 nuclear factor kappa B subunit 1 Homo sapiens 116-125 24999220-0 2014 The cannabinoid receptor 2 agonist, beta-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. caryophyllene 36-54 cannabinoid receptor 2 (macrophage) Mus musculus 4-26 24999220-3 2014 The CB2 receptor agonist, beta-caryophyllene (BCP) was used to investigate the role of the CB2 receptors in mediating alcohol intake and ethanol-induced conditioned place preference (EtOH-CPP) and sensitivity in mice. caryophyllene 26-44 cannabinoid receptor 2 (macrophage) Mus musculus 4-7 24999220-3 2014 The CB2 receptor agonist, beta-caryophyllene (BCP) was used to investigate the role of the CB2 receptors in mediating alcohol intake and ethanol-induced conditioned place preference (EtOH-CPP) and sensitivity in mice. caryophyllene 46-49 cannabinoid receptor 2 (macrophage) Mus musculus 4-7 24930711-0 2014 beta-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 22-25 24930711-2 2014 The aim of the current experiments was to test the effects of the CB2 receptor potent-selective agonist beta-caryophyllene (BCP) in animals subjected to models of anxiolytic- and antidepressant-like effects. caryophyllene 104-122 cannabinoid receptor 2 (macrophage) Mus musculus 66-69 24930711-2 2014 The aim of the current experiments was to test the effects of the CB2 receptor potent-selective agonist beta-caryophyllene (BCP) in animals subjected to models of anxiolytic- and antidepressant-like effects. caryophyllene 124-127 cannabinoid receptor 2 (macrophage) Mus musculus 66-69 24930711-10 2014 Most importantly, pre-administration of the CB2 receptor antagonist AM630, fully abrogated the anxiolytic and the anti-depressant effects of BCP. caryophyllene 141-144 cannabinoid receptor 2 (macrophage) Mus musculus 44-47 24184450-3 2013 Recombinant GhTPS1 accepted farnesyl pyrophosphate as substrate and produced (E)-beta-caryophyllene and alpha-humulene. caryophyllene 77-99 (-)-germacrene D synthase-like Gossypium hirsutum 12-18 24210682-0 2014 The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. caryophyllene 56-74 cannabinoid receptor 2 (macrophage) Mus musculus 16-19 25374376-1 2014 The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse. caryophyllene 75-93 prohibitin 2 Mus musculus 140-143 25374376-1 2014 The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse. caryophyllene 95-97 prohibitin 2 Mus musculus 140-143 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 46-48 prohibitin 2 Mus musculus 116-119 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 46-48 prohibitin 2 Mus musculus 307-310 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 116-119 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 307-310 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 116-119 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 307-310 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 116-119 25374376-6 2014 We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%. caryophyllene 145-147 prohibitin 2 Mus musculus 307-310 24074555-6 2013 By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product. caryophyllene 168-186 (-)-germacrene D synthase-like Gossypium hirsutum 66-72 24074555-6 2013 By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product. caryophyllene 168-186 terpene synthase 10-like Gossypium hirsutum 77-83 24856059-0 2014 trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-alpha. caryophyllene 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 54-102 24856059-2 2014 We demonstrated that trans-caryophyllene, a flavor compound in plant foods and teas, activates peroxisome proliferator-activated receptor (PPAR)-alpha through direct interaction with the ligand-binding domain of PPAR-alpha. caryophyllene 21-40 peroxisome proliferator activated receptor alpha Homo sapiens 95-150 24856059-2 2014 We demonstrated that trans-caryophyllene, a flavor compound in plant foods and teas, activates peroxisome proliferator-activated receptor (PPAR)-alpha through direct interaction with the ligand-binding domain of PPAR-alpha. caryophyllene 21-40 peroxisome proliferator activated receptor alpha Homo sapiens 212-222 24856059-7 2014 In HepG2 cells transfected with small interfering RNA of PPAR-alpha, the effects of trans-caryophyllene on PPAR-alpha responsive gene expressions, intracellular triglyceride, fatty acid uptake and oxidation were disappeared. caryophyllene 84-103 peroxisome proliferator activated receptor alpha Homo sapiens 57-67 24856059-7 2014 In HepG2 cells transfected with small interfering RNA of PPAR-alpha, the effects of trans-caryophyllene on PPAR-alpha responsive gene expressions, intracellular triglyceride, fatty acid uptake and oxidation were disappeared. caryophyllene 84-103 peroxisome proliferator activated receptor alpha Homo sapiens 107-117 24856059-8 2014 These results indicate that the aroma compound, trans-caryophyllene, is PPAR-alpha agonist thus regulates cellular lipid metabolism in PPAR-alpha dependent manners. caryophyllene 48-67 peroxisome proliferator activated receptor alpha Homo sapiens 72-82 24856059-8 2014 These results indicate that the aroma compound, trans-caryophyllene, is PPAR-alpha agonist thus regulates cellular lipid metabolism in PPAR-alpha dependent manners. caryophyllene 48-67 peroxisome proliferator activated receptor alpha Homo sapiens 135-145 24486541-2 2014 Trans-caryophyllene (TC), an important constituent of the essential oil of several species of plants, has been reported to activate the type 2 cannabinoid receptor (CB2R). caryophyllene 0-19 cannabinoid receptor 2 (macrophage) Mus musculus 165-168 24486541-2 2014 Trans-caryophyllene (TC), an important constituent of the essential oil of several species of plants, has been reported to activate the type 2 cannabinoid receptor (CB2R). caryophyllene 21-23 cannabinoid receptor 2 (macrophage) Mus musculus 165-168 24486541-5 2014 However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. caryophyllene 106-108 cannabinoid receptor 2 (macrophage) Mus musculus 23-27 24486541-5 2014 However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. caryophyllene 106-108 cannabinoid receptor 2 (macrophage) Mus musculus 195-199 24486541-5 2014 However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. caryophyllene 153-155 cannabinoid receptor 2 (macrophage) Mus musculus 23-27 24486541-5 2014 However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. caryophyllene 153-155 cannabinoid receptor 2 (macrophage) Mus musculus 195-199 24486541-6 2014 Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. caryophyllene 47-49 ADP-ribosylation factor 6 Mus musculus 93-97 24486541-6 2014 Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. caryophyllene 47-49 Rac family small GTPase 1 Mus musculus 109-113 24486541-6 2014 Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. caryophyllene 47-49 cell division cycle 42 Mus musculus 118-123 24486541-7 2014 Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS. caryophyllene 53-55 ADP-ribosylation factor 6 Mus musculus 13-17 24486541-7 2014 Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS. caryophyllene 53-55 ADP-ribosylation factor 6 Mus musculus 85-89 24486541-7 2014 Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS. caryophyllene 131-133 ADP-ribosylation factor 6 Mus musculus 13-17 24486541-7 2014 Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS. caryophyllene 131-133 ADP-ribosylation factor 6 Mus musculus 85-89 24055516-10 2014 Trans-caryophyllene treatment also decreased the IL-1beta levels. caryophyllene 0-19 interleukin 1 beta Mus musculus 49-57 25171128-0 2014 beta-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARgamma pathway. caryophyllene 0-18 presenilin 1 Mus musculus 67-70 25171128-0 2014 beta-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARgamma pathway. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 84-87 25171128-0 2014 beta-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARgamma pathway. caryophyllene 0-18 peroxisome proliferator activated receptor gamma Mus musculus 116-125 25171128-2 2014 Recently, the plant metabolite beta-caryophyllene was shown to selectively bind to CB2 receptor and act as a full agonist. caryophyllene 31-49 cannabinoid receptor 2 (macrophage) Mus musculus 83-86 25171128-4 2014 RESULTS: beta-Caryophyllene, given orally, prevented cognitive impairment in APP/PS1 mice, and this positive cognitive effect was associated with reduced beta-amyloid burden in both the hippocampus and the cerebral cortex. caryophyllene 9-27 presenilin 1 Mus musculus 81-84 25171128-5 2014 Moreover, beta-caryophyllene reduced astrogliosis and microglial activation as well as the levels of COX-2 protein and the mRNA levels of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the cerebral cortex. caryophyllene 10-28 cytochrome c oxidase II, mitochondrial Mus musculus 101-106 25171128-5 2014 Moreover, beta-caryophyllene reduced astrogliosis and microglial activation as well as the levels of COX-2 protein and the mRNA levels of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the cerebral cortex. caryophyllene 10-28 tumor necrosis factor Mus musculus 168-195 25171128-5 2014 Moreover, beta-caryophyllene reduced astrogliosis and microglial activation as well as the levels of COX-2 protein and the mRNA levels of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the cerebral cortex. caryophyllene 10-28 interleukin 1 beta Mus musculus 200-217 25171128-6 2014 The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effects of beta-caryophyllene on APP/PS1 mice. caryophyllene 120-138 cannabinoid receptor 2 (macrophage) Mus musculus 15-18 25171128-6 2014 The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effects of beta-caryophyllene on APP/PS1 mice. caryophyllene 120-138 peroxisome proliferator activated receptor gamma Mus musculus 43-52 25171128-6 2014 The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effects of beta-caryophyllene on APP/PS1 mice. caryophyllene 120-138 presenilin 1 Mus musculus 146-149 25171128-7 2014 CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD. caryophyllene 93-111 cannabinoid receptor 2 (macrophage) Mus musculus 121-124 25171128-7 2014 CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD. caryophyllene 93-111 peroxisome proliferator activated receptor gamma Mus musculus 153-162 25171128-7 2014 CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD. caryophyllene 183-201 peroxisome proliferator activated receptor gamma Mus musculus 153-162 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 108-127 sirtuin 1 Homo sapiens 144-153 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 129-131 PPARG coactivator 1 alpha Homo sapiens 302-312 23747418-5 2013 This use of TC treatment increases the expression of genes linked to the fatty acid oxidation pathway in a SIRT1/PGC-1alpha-dependent mechanism and also drastically accelerates the rate of complete fatty acid oxidation in C2C12 myotubes, neither of which occur when CB2R mRNA is knocked down using siRNA. caryophyllene 12-14 sirtuin 1 Homo sapiens 107-112 23747418-5 2013 This use of TC treatment increases the expression of genes linked to the fatty acid oxidation pathway in a SIRT1/PGC-1alpha-dependent mechanism and also drastically accelerates the rate of complete fatty acid oxidation in C2C12 myotubes, neither of which occur when CB2R mRNA is knocked down using siRNA. caryophyllene 12-14 PPARG coactivator 1 alpha Homo sapiens 113-123 23790892-5 2013 In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses. caryophyllene 13-36 interleukin 2 Mus musculus 154-158 23790892-5 2013 In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses. caryophyllene 13-36 negative elongation factor complex member C/D, Th1l Mus musculus 160-163 23790892-5 2013 In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses. caryophyllene 13-36 interleukin 10 Mus musculus 169-174 23790892-5 2013 In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses. caryophyllene 13-36 heart and neural crest derivatives expressed 2 Mus musculus 176-179 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 108-127 sirtuin 1 Homo sapiens 155-160 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 108-127 cAMP responsive element binding protein 1 Homo sapiens 220-257 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 108-127 cAMP responsive element binding protein 1 Homo sapiens 259-263 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 108-127 PPARG coactivator 1 alpha Homo sapiens 302-312 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 129-131 sirtuin 1 Homo sapiens 144-153 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 129-131 sirtuin 1 Homo sapiens 155-160 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 129-131 cAMP responsive element binding protein 1 Homo sapiens 220-257 23747418-4 2013 We have found that CB2R is expressed in differentiated C2C12 myotubes, and that use of the specific agonist trans-caryophyllene (TC) stimulates sirtuin 1 (SIRT1) deacetylase activity by increasing the phosphorylation of cAMP response element-binding protein (CREB), thus leading to increased levels of PGC-1alpha deacetylation. caryophyllene 129-131 cAMP responsive element binding protein 1 Homo sapiens 259-263 23734999-6 2013 By contrast, treatments with beta-caryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E2 at a 100 muM concentration. caryophyllene 29-47 interleukin 1 beta Homo sapiens 129-151 23734999-6 2013 By contrast, treatments with beta-caryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E2 at a 100 muM concentration. caryophyllene 29-47 interleukin 6 Homo sapiens 153-157 23734999-6 2013 By contrast, treatments with beta-caryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E2 at a 100 muM concentration. caryophyllene 29-47 prostaglandin-endoperoxide synthase 2 Homo sapiens 163-179 23414569-6 2013 Western blot analysis demonstrated that TC enhanced phosphorylation of AMP-activated protein kinase (AMPK) and cAMP responsive element-binding protein (CREB), and increased expression of the CREB target gene product, brain-derived neurotrophic factor. caryophyllene 40-42 cAMP responsive element binding protein 1 Rattus norvegicus 152-156 23138934-12 2013 The antinociceptive effect produced by BCP was prevented by pretreatment with AM630, a selective CB2 receptor antagonist, but not by AM251, a selective CB1 receptor antagonist. caryophyllene 39-42 cannabinoid receptor 2 (macrophage) Mus musculus 97-100 23138934-14 2013 Pretreatment with naloxone methiodide, a peripherally acting antagonist for opioid receptors and antisera against beta-endorphin, resulted in a significant antagonizing effect on BCP-induced antinociception. caryophyllene 179-182 pro-opiomelanocortin-alpha Mus musculus 114-128 23138934-18 2013 BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid beta-endorphin. caryophyllene 0-3 cannabinoid receptor 2 (macrophage) Mus musculus 33-36 23138934-18 2013 BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid beta-endorphin. caryophyllene 0-3 pro-opiomelanocortin-alpha Mus musculus 127-141 23414569-6 2013 Western blot analysis demonstrated that TC enhanced phosphorylation of AMP-activated protein kinase (AMPK) and cAMP responsive element-binding protein (CREB), and increased expression of the CREB target gene product, brain-derived neurotrophic factor. caryophyllene 40-42 cAMP responsive element binding protein 1 Rattus norvegicus 111-150 23414569-6 2013 Western blot analysis demonstrated that TC enhanced phosphorylation of AMP-activated protein kinase (AMPK) and cAMP responsive element-binding protein (CREB), and increased expression of the CREB target gene product, brain-derived neurotrophic factor. caryophyllene 40-42 cAMP responsive element binding protein 1 Rattus norvegicus 191-195 23414569-6 2013 Western blot analysis demonstrated that TC enhanced phosphorylation of AMP-activated protein kinase (AMPK) and cAMP responsive element-binding protein (CREB), and increased expression of the CREB target gene product, brain-derived neurotrophic factor. caryophyllene 40-42 brain-derived neurotrophic factor Rattus norvegicus 217-250 23414569-8 2013 Selective AMPK and CREB inhibitors abolished the neuroprotective effects of TC. caryophyllene 76-78 cAMP responsive element binding protein 1 Rattus norvegicus 19-23 23414569-9 2013 In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema, and increased phosphorylated CREB and brain-derived neurotrophic factor expression in neurons. caryophyllene 38-40 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 23414569-9 2013 In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema, and increased phosphorylated CREB and brain-derived neurotrophic factor expression in neurons. caryophyllene 38-40 brain-derived neurotrophic factor Rattus norvegicus 122-155 23414569-11 2013 Collectively, these data demonstrate that cortical CB2R activation by TC ameliorates ischemic injury, potentially through modulation of AMPK/CREB signaling, and suggest that cortical CB2Rs might serve as a putative therapeutic target for cerebral ischemia. caryophyllene 70-72 cAMP responsive element binding protein 1 Rattus norvegicus 141-145 23414569-11 2013 Collectively, these data demonstrate that cortical CB2R activation by TC ameliorates ischemic injury, potentially through modulation of AMPK/CREB signaling, and suggest that cortical CB2Rs might serve as a putative therapeutic target for cerebral ischemia. caryophyllene 70-72 cannabinoid receptor 2 Rattus norvegicus 51-54 23259547-5 2012 Tandem heterozygous deletion of a set of three genes, the ubiquitin ligases ubc7 and ssm4/doa10, and the ER resident protein pho86, led to an 11-fold increase in caryophyllene yields (125 mg/L in shake flasks) compared to cells lacking these modifications. caryophyllene 162-175 E2 ubiquitin-conjugating protein UBC7 Saccharomyces cerevisiae S288C 76-80 23259547-5 2012 Tandem heterozygous deletion of a set of three genes, the ubiquitin ligases ubc7 and ssm4/doa10, and the ER resident protein pho86, led to an 11-fold increase in caryophyllene yields (125 mg/L in shake flasks) compared to cells lacking these modifications. caryophyllene 162-175 E3 ubiquitin-protein ligase SSM4 Saccharomyces cerevisiae S288C 85-89 23259547-5 2012 Tandem heterozygous deletion of a set of three genes, the ubiquitin ligases ubc7 and ssm4/doa10, and the ER resident protein pho86, led to an 11-fold increase in caryophyllene yields (125 mg/L in shake flasks) compared to cells lacking these modifications. caryophyllene 162-175 E3 ubiquitin-protein ligase SSM4 Saccharomyces cerevisiae S288C 90-95 21356367-6 2011 Moreover, BCP enhanced IL-4 levels and forkhead box P3 mRNA expression in the mouse colon and reduced cytokine levels (tumor necrosis factor-alpha, keratinocyte-derived chemokine, and macrophage-inflammatory protein-2) in a culture of macrophages stimulated with lipopolysaccharide. caryophyllene 10-13 interleukin 4 Mus musculus 23-27 22669881-4 2012 The induction of TPS21 and TPS11 results in increased emission of sesquiterpene, especially (E)-beta-caryophyllene. caryophyllene 92-114 terpene synthase 21 Arabidopsis thaliana 17-22 22669881-4 2012 The induction of TPS21 and TPS11 results in increased emission of sesquiterpene, especially (E)-beta-caryophyllene. caryophyllene 92-114 trehalose phosphatase/synthase 11 Arabidopsis thaliana 27-32 22326488-4 2012 beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). caryophyllene 0-18 mast cell protease 1 Mus musculus 152-157 22326488-4 2012 beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). caryophyllene 0-18 chemokine (C-X-C motif) ligand 2 Mus musculus 162-167 22326488-4 2012 beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). caryophyllene 0-18 tumor necrosis factor Mus musculus 179-188 22326488-4 2012 beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). caryophyllene 0-18 interleukin 1 beta Mus musculus 193-201 22326488-4 2012 beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). caryophyllene 0-18 intercellular adhesion molecule 1 Mus musculus 221-227 21356367-0 2011 beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 83-86 21356367-0 2011 beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway. caryophyllene 0-18 peroxisome proliferator activated receptor gamma Mus musculus 111-120 21356367-2 2011 Recently, the plant metabolite (E)-beta-caryophyllene (BCP) was shown to bind to and activate CB2. caryophyllene 31-53 cannabinoid receptor 2 (macrophage) Mus musculus 94-97 21356367-6 2011 Moreover, BCP enhanced IL-4 levels and forkhead box P3 mRNA expression in the mouse colon and reduced cytokine levels (tumor necrosis factor-alpha, keratinocyte-derived chemokine, and macrophage-inflammatory protein-2) in a culture of macrophages stimulated with lipopolysaccharide. caryophyllene 10-13 forkhead box P3 Mus musculus 39-54 21356367-2 2011 Recently, the plant metabolite (E)-beta-caryophyllene (BCP) was shown to bind to and activate CB2. caryophyllene 55-58 cannabinoid receptor 2 (macrophage) Mus musculus 94-97 21356367-5 2011 BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor kappaB, IkappaB-kinase alpha/beta, cAMP response element binding and the expression of caspase-3 and Ki-67. caryophyllene 0-3 mitogen-activated protein kinase 3 Mus musculus 47-111 21356367-6 2011 Moreover, BCP enhanced IL-4 levels and forkhead box P3 mRNA expression in the mouse colon and reduced cytokine levels (tumor necrosis factor-alpha, keratinocyte-derived chemokine, and macrophage-inflammatory protein-2) in a culture of macrophages stimulated with lipopolysaccharide. caryophyllene 10-13 tumor necrosis factor Mus musculus 102-146 21356367-5 2011 BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor kappaB, IkappaB-kinase alpha/beta, cAMP response element binding and the expression of caspase-3 and Ki-67. caryophyllene 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 113-133 21356367-5 2011 BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor kappaB, IkappaB-kinase alpha/beta, cAMP response element binding and the expression of caspase-3 and Ki-67. caryophyllene 0-3 caspase 3 Mus musculus 192-201 21356367-6 2011 Moreover, BCP enhanced IL-4 levels and forkhead box P3 mRNA expression in the mouse colon and reduced cytokine levels (tumor necrosis factor-alpha, keratinocyte-derived chemokine, and macrophage-inflammatory protein-2) in a culture of macrophages stimulated with lipopolysaccharide. caryophyllene 10-13 chemokine (C-X-C motif) ligand 2 Mus musculus 184-217 21356367-7 2011 The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effect of BCP. caryophyllene 119-122 cannabinoid receptor 2 (macrophage) Mus musculus 15-18 21356367-7 2011 The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effect of BCP. caryophyllene 119-122 peroxisome proliferator activated receptor gamma Mus musculus 43-52 21356367-9 2011 These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARgamma pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease. caryophyllene 63-66 cannabinoid receptor 2 (macrophage) Mus musculus 76-79 21356367-9 2011 These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARgamma pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease. caryophyllene 63-66 peroxisome proliferator activated receptor gamma Mus musculus 88-97 19322583-14 2009 Recombinant AlCarS converts the sesquiterpene precursor, farnesyl diphosphate, into (E)-beta-caryophyllene with alpha-humulene and alpha-copaene as minor products indicating its close functional relationship to the A. thaliana AtTPS21. caryophyllene 84-106 terpene synthase 21 Arabidopsis thaliana 227-234 18296628-2 2008 We identified a maize terpene synthase, Terpene Synthase 23 (TPS23), that produces (E)-beta-caryophyllene from farnesyl diphosphate. caryophyllene 83-105 (E)-beta-caryophyllene synthase Zea mays 40-59 19921589-3 2009 Two compounds identified in the n-hexane extract, linalool and beta-caryophyllene, were found to be active against C32 cells (IC(50) values of 23.2 and 20.1 microg mL(-1), respectively). caryophyllene 63-81 chemokine like factor Homo sapiens 115-118 18264780-8 2008 Heterologous expression in E. coli of CmTpsNY produced mainly delta-copaene, alpha-copaene, beta-caryophyllene, germacrene D, alpha-muurolene, gamma-cadinene, delta-cadinene, and alpha-cadinene, while CmTpsDul produced alpha-farnesene only. caryophyllene 92-110 (+)-gamma-cadinene synthase Cucumis melo 38-45 18296628-2 2008 We identified a maize terpene synthase, Terpene Synthase 23 (TPS23), that produces (E)-beta-caryophyllene from farnesyl diphosphate. caryophyllene 83-105 (E)-beta-caryophyllene synthase Zea mays 61-66 18296628-7 2008 The gene encoding TPS23 is active in teosinte species and European maize lines, but decreased transcription in most North American lines resulted in the loss of (E)-beta-caryophyllene production. caryophyllene 161-183 (E)-beta-caryophyllene synthase Zea mays 18-23 17188718-7 2007 BCP treatment (300 mg/kg) also significantly reduced the inflammation of colon and reversed the increase in MPO activity that had been induced by exposure to DSS. caryophyllene 0-3 myeloperoxidase Mus musculus 108-111 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 CD14 antigen Mus musculus 129-133 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 toll-like receptor 4 Mus musculus 134-138 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 interleukin 1 beta Mus musculus 213-221 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 interleukin 6 Mus musculus 223-227 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 chemokine (C-X-C motif) ligand 15 Mus musculus 229-233 19704783-8 2008 Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response. caryophyllene 30-48 tumor necrosis factor Mus musculus 238-246 19704783-9 2008 In this addendum, the CB(2) receptor-dependent effect of beta-caryophyllene on LPS-triggered activation of the kinases Erk1/2 and JNK1/2 are further discussed with respect to the possibility that both CB(2) inverse agonists and agonists, independent of their G-protein signaling, may block LPS-triggered activation of MAPKs, leading to inhibition of proinflammatory cytokine expression and attenuation of inflammation. caryophyllene 57-75 mitogen-activated protein kinase 3 Mus musculus 119-125 19704783-9 2008 In this addendum, the CB(2) receptor-dependent effect of beta-caryophyllene on LPS-triggered activation of the kinases Erk1/2 and JNK1/2 are further discussed with respect to the possibility that both CB(2) inverse agonists and agonists, independent of their G-protein signaling, may block LPS-triggered activation of MAPKs, leading to inhibition of proinflammatory cytokine expression and attenuation of inflammation. caryophyllene 57-75 mitogen-activated protein kinase 8 Mus musculus 130-136 17559833-5 2007 Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. caryophyllene 183-206 tumor necrosis factor Rattus norvegicus 223-231 17716654-4 2007 Investigation of the effects of the volatile oil (and terpenes) treatment on total natural killer cells (NK cell) activity from tumor-bearing mice as a possible mechanism of these compounds in vivo revealed that volatile oil and beta-caryophyllene significantly improved NK cell cytotoxicity against YAC-1, a Moloney virus-induced mouse T-cell lymphoma of A/SN origin and Ehrlich ascites cells. caryophyllene 229-247 ADP-ribosyltransferase 1 Mus musculus 300-305 17188718-8 2007 Further, BCP significantly suppressed the serum level of IL-6 protein (a 55% reduction) as well as the level of IL-6 mRNA in the tissue. caryophyllene 9-12 interleukin 6 Mus musculus 57-61 17188718-8 2007 Further, BCP significantly suppressed the serum level of IL-6 protein (a 55% reduction) as well as the level of IL-6 mRNA in the tissue. caryophyllene 9-12 interleukin 6 Mus musculus 112-116 15453708-5 2004 Sesamol, vanillyl alcohol, and trans-ferulic acid exhibited moderate inhibitory actions on the Hsp60-induced cell proliferation; zerumbone, humulene, and caryophylene effectively inhibited it at low concentrations with IC(50) values of 529, 122, and 110 nM, respectively. caryophyllene 154-166 heat shock protein family D (Hsp60) member 1 Rattus norvegicus 95-100 33588052-0 2021 beta-caryophyllene, a natural bicyclic sesquiterpene attenuates beta-adrenergic agonist-induced myocardial injury in a cannabinoid receptor-2 dependent and independent manner. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 119-141 33588052-15 2021 The present study findings demonstrate that BCP possess the potential to protect myocardium against ISO-induced MI in a CB2-dependent and independent manner. caryophyllene 44-47 cannabinoid receptor 2 Rattus norvegicus 120-123 34875285-5 2022 In the first approach, an acute treatment with BCP was effective against seizuring activity induced by pentylenetetrazole (PTZ) in wildtype (Scn1aWT/WT) and also in Syn-Cre/Scn1aWT/A1783V mice, with these last animals having a greater susceptibility to PTZ. caryophyllene 47-50 sodium channel, voltage-gated, type I, alpha Mus musculus 141-148 33809114-4 2021 Among them, we focused on the natural sesquiterpene and cannabinoid type 2 (CB2) receptor agonist Trans-beta-caryophyllene (BCP) by analyzing its role in enhancing glucose metabolism in skeletal muscle cells. caryophyllene 98-122 cannabinoid receptor 2 Homo sapiens 56-74 33809114-4 2021 Among them, we focused on the natural sesquiterpene and cannabinoid type 2 (CB2) receptor agonist Trans-beta-caryophyllene (BCP) by analyzing its role in enhancing glucose metabolism in skeletal muscle cells. caryophyllene 98-122 cannabinoid receptor 2 Homo sapiens 76-79 33809114-4 2021 Among them, we focused on the natural sesquiterpene and cannabinoid type 2 (CB2) receptor agonist Trans-beta-caryophyllene (BCP) by analyzing its role in enhancing glucose metabolism in skeletal muscle cells. caryophyllene 124-127 cannabinoid receptor 2 Homo sapiens 56-74 33809114-4 2021 Among them, we focused on the natural sesquiterpene and cannabinoid type 2 (CB2) receptor agonist Trans-beta-caryophyllene (BCP) by analyzing its role in enhancing glucose metabolism in skeletal muscle cells. caryophyllene 124-127 cannabinoid receptor 2 Homo sapiens 76-79 33809114-9 2021 Our results show that in myotubes, BCP significantly enhances glucose uptake, glycolytic and oxidative pathways, and ATP synthesis through a CB2-dependent mechanism. caryophyllene 35-38 cannabinoid receptor 2 Homo sapiens 141-144 34875285-5 2022 In the first approach, an acute treatment with BCP was effective against seizuring activity induced by pentylenetetrazole (PTZ) in wildtype (Scn1aWT/WT) and also in Syn-Cre/Scn1aWT/A1783V mice, with these last animals having a greater susceptibility to PTZ. caryophyllene 47-50 joined toes Mus musculus 165-168 34875285-5 2022 In the first approach, an acute treatment with BCP was effective against seizuring activity induced by pentylenetetrazole (PTZ) in wildtype (Scn1aWT/WT) and also in Syn-Cre/Scn1aWT/A1783V mice, with these last animals having a greater susceptibility to PTZ. caryophyllene 47-50 sodium channel, voltage-gated, type I, alpha Mus musculus 173-180 34875285-8 2022 Thus, BCP corrected important behavioural abnormalities of Syn-Cre/Scn1aWT/A1783V mice (e.g. delayed appearance of hindlimb grasp reflex, induction of clasping response, motor hyperactivity, altered social interaction and memory impairment), attenuated weight loss, and slightly delayed premature mortality. caryophyllene 6-9 joined toes Mus musculus 59-62 34875285-8 2022 Thus, BCP corrected important behavioural abnormalities of Syn-Cre/Scn1aWT/A1783V mice (e.g. delayed appearance of hindlimb grasp reflex, induction of clasping response, motor hyperactivity, altered social interaction and memory impairment), attenuated weight loss, and slightly delayed premature mortality. caryophyllene 6-9 sodium channel, voltage-gated, type I, alpha Mus musculus 67-74 34875285-9 2022 Again, these benefits were paralleled by a BCP-induced reduction in reactive astrogliosis and microgliosis in the prefrontal cortex and the hippocampal dentate gyrus typical of Syn-Cre/Scn1aWT/A1783V mice. caryophyllene 43-46 joined toes Mus musculus 177-180 34875285-9 2022 Again, these benefits were paralleled by a BCP-induced reduction in reactive astrogliosis and microgliosis in the prefrontal cortex and the hippocampal dentate gyrus typical of Syn-Cre/Scn1aWT/A1783V mice. caryophyllene 43-46 sodium channel, voltage-gated, type I, alpha Mus musculus 185-192 34856202-4 2022 beta-Caryophyllene (BCP) is a low-efficacy natural agonist of CB2 and a common constituent of human diet with well-established anti-inflammatory properties. caryophyllene 0-18 cannabinoid receptor 2 Homo sapiens 62-65 34856202-4 2022 beta-Caryophyllene (BCP) is a low-efficacy natural agonist of CB2 and a common constituent of human diet with well-established anti-inflammatory properties. caryophyllene 20-23 cannabinoid receptor 2 Homo sapiens 62-65 34856202-8 2022 Experiments established the dose-response effects of BCP and pharmacological mechanisms of the antinociceptive action dependent on CB2 and opioid receptors. caryophyllene 53-56 cannabinoid receptor 2 Homo sapiens 131-134 34860602-1 2022 Beta-caryophyllene (BCP), a cannabinoid 2 receptor (CB2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 28-50 34942451-11 2021 Interestingly, lower levels of GFAP, c-Fos and 3-NT were observed in animals receiving beta-caryophyllene and pregabalin treatments. caryophyllene 87-105 glial fibrillary acidic protein Rattus norvegicus 31-35 34942451-11 2021 Interestingly, lower levels of GFAP, c-Fos and 3-NT were observed in animals receiving beta-caryophyllene and pregabalin treatments. caryophyllene 87-105 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-42 34860602-1 2022 Beta-caryophyllene (BCP), a cannabinoid 2 receptor (CB2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 52-55 34860602-1 2022 Beta-caryophyllene (BCP), a cannabinoid 2 receptor (CB2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. caryophyllene 20-23 cannabinoid receptor 2 Rattus norvegicus 28-50 34860602-1 2022 Beta-caryophyllene (BCP), a cannabinoid 2 receptor (CB2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. caryophyllene 20-23 cannabinoid receptor 2 Rattus norvegicus 52-55 34860602-3 2022 Considering the role of CB2 receptor activation and NO regulation in cardiovascular diseases, the combination of BCP with LA may be a possible treatment of diabetic cardiomyopathy (DCM). caryophyllene 113-116 cannabinoid receptor 2 Rattus norvegicus 24-27 34860602-9 2022 The combination of BCP (200 mg/kg) with LA (200 mg/kg) significantly normalized the hemodynamic parameters and decreased the glucose, cardiac markers, IL-6 and TNF-alpha levels. caryophyllene 19-22 interleukin 6 Rattus norvegicus 151-155 34860602-9 2022 The combination of BCP (200 mg/kg) with LA (200 mg/kg) significantly normalized the hemodynamic parameters and decreased the glucose, cardiac markers, IL-6 and TNF-alpha levels. caryophyllene 19-22 tumor necrosis factor Rattus norvegicus 160-169 34816538-0 2021 beta-Caryophyllene inhibits Fas- receptor and caspase-mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction. caryophyllene 0-18 Fas cell surface death receptor Rattus norvegicus 28-41 34816538-0 2021 beta-Caryophyllene inhibits Fas- receptor and caspase-mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction. caryophyllene 0-18 caspase 8 Rattus norvegicus 46-53 34816538-1 2021 We planned to appraise the effects of beta-caryophyllene on Fas- receptor and caspase-mediated apoptosis signaling pathway and endothelial dysfunction in rats infarcted with isoproterenol. caryophyllene 38-56 Fas cell surface death receptor Rattus norvegicus 60-73 34816538-1 2021 We planned to appraise the effects of beta-caryophyllene on Fas- receptor and caspase-mediated apoptosis signaling pathway and endothelial dysfunction in rats infarcted with isoproterenol. caryophyllene 38-56 caspase 8 Rattus norvegicus 78-85 34314522-0 2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. caryophyllene 77-95 adiponectin receptor 1 Rattus norvegicus 18-25 34778972-0 2021 A standardized black pepper seed extract containing beta-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins. caryophyllene 52-70 brain derived neurotrophic factor Mus musculus 159-192 34778972-1 2021 beta-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 95-122 34778972-1 2021 beta-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 124-127 34778972-1 2021 beta-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 95-122 34778972-1 2021 beta-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. caryophyllene 20-23 cannabinoid receptor 2 (macrophage) Mus musculus 124-127 34846548-10 2022 The potency of beta-caryophyllene to reverse mechanical allodynia decreased 1.80-fold in CB2R (-/-) mice. caryophyllene 15-33 cannabinoid receptor 2 (macrophage) Mus musculus 89-93 34830893-6 2021 BCP treatment reduced cell proliferation through CB2R stimulation; notably, BCP considerably increased the pro-apoptotic protein Bax and decreased the anti-apoptotic molecule Bcl-2. caryophyllene 0-3 BCL2 associated X, apoptosis regulator Homo sapiens 129-132 34830893-6 2021 BCP treatment reduced cell proliferation through CB2R stimulation; notably, BCP considerably increased the pro-apoptotic protein Bax and decreased the anti-apoptotic molecule Bcl-2. caryophyllene 0-3 BCL2 apoptosis regulator Homo sapiens 175-180 34778972-20 2021 The findings from this study strongly suggest the beneficial neuroactive properties of black pepper seed extract having the presence of BCP, a CB2 receptor agonist. caryophyllene 136-139 cannabinoid receptor 2 (macrophage) Mus musculus 143-146 34314522-0 2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. caryophyllene 77-95 adiponectin receptor 2 Rattus norvegicus 26-33 34314522-0 2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. caryophyllene 77-95 NFE2 like bZIP transcription factor 2 Rattus norvegicus 38-42 34314522-0 2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. caryophyllene 77-95 heme oxygenase 1 Rattus norvegicus 43-47 34314522-6 2021 In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway. caryophyllene 71-89 adiponectin receptor 1 Rattus norvegicus 136-143 34314522-6 2021 In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway. caryophyllene 71-89 adiponectin receptor 2 Rattus norvegicus 144-151 34314522-6 2021 In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway. caryophyllene 71-89 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-160 34314522-6 2021 In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway. caryophyllene 71-89 heme oxygenase 1 Rattus norvegicus 161-165 34318533-0 2021 beta-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study. caryophyllene 0-18 signal transducer and activator of transcription 3 Homo sapiens 88-94 34468068-0 2021 beta-Caryophyllene may attenuate hyperoxaluria-induced kidney dysfunction in rats by regulating stress marker KIM-1/MCP-1 and NF-kappaB signaling pathway. caryophyllene 0-18 hepatitis A virus cellular receptor 1 Rattus norvegicus 110-115 34468068-0 2021 beta-Caryophyllene may attenuate hyperoxaluria-induced kidney dysfunction in rats by regulating stress marker KIM-1/MCP-1 and NF-kappaB signaling pathway. caryophyllene 0-18 C-C motif chemokine ligand 2 Rattus norvegicus 116-121 34318533-0 2021 beta-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study. caryophyllene 0-18 mechanistic target of rapamycin kinase Homo sapiens 95-99 34318533-0 2021 beta-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study. caryophyllene 0-18 AKT serine/threonine kinase 1 Homo sapiens 100-103 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 59-77 signal transducer and activator of transcription 3 Homo sapiens 216-222 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 59-77 mechanistic target of rapamycin kinase Homo sapiens 223-227 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 59-77 AKT serine/threonine kinase 1 Homo sapiens 228-231 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 79-82 signal transducer and activator of transcription 3 Homo sapiens 216-222 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 79-82 mechanistic target of rapamycin kinase Homo sapiens 223-227 34318533-1 2021 The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism. caryophyllene 79-82 AKT serine/threonine kinase 1 Homo sapiens 228-231 34638895-5 2021 BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF) secretion from human umbilical vein endothelial cells and sprouting of rat aorta microvessels. caryophyllene 0-3 vascular endothelial growth factor A Homo sapiens 138-172 34638895-5 2021 BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF) secretion from human umbilical vein endothelial cells and sprouting of rat aorta microvessels. caryophyllene 0-3 vascular endothelial growth factor A Homo sapiens 174-178 34638895-10 2021 In addition, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions. caryophyllene 13-16 X-linked inhibitor of apoptosis Homo sapiens 88-92 34638895-6 2021 BCP has a probable binding at Site#0 on the surface of VEGFR2. caryophyllene 0-3 kinase insert domain receptor Homo sapiens 55-61 34638895-10 2021 In addition, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions. caryophyllene 13-16 H3 histone pseudogene 16 Homo sapiens 125-128 34638895-10 2021 In addition, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions. caryophyllene 13-16 heat shock protein family D (Hsp60) member 1 Homo sapiens 61-66 34638895-10 2021 In addition, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions. caryophyllene 13-16 HtrA serine peptidase 1 Homo sapiens 68-72 34125438-12 2021 A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells. caryophyllene 284-287 mitochondrially encoded cytochrome c oxidase II Homo sapiens 54-58 34566647-0 2021 beta-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 134-137 34566647-0 2021 beta-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms. caryophyllene 0-18 cannabinoid receptor 2 (macrophage) Mus musculus 146-149 34566647-5 2021 The attenuating effects of BCP were partially blocked by AM 630, a selective CB2 receptor antagonist. caryophyllene 27-30 cannabinoid receptor 2 Rattus norvegicus 77-89 34566647-6 2021 Genetic deletion of CB2 receptors in CB2-knockout (CB2-KO) mice also blocked low dose BCP-induced reduction in METH self-administration, suggesting possible involvement of a CB2 receptor mechanism. caryophyllene 86-89 cannabinoid receptor 2 (macrophage) Mus musculus 20-23 34566647-6 2021 Genetic deletion of CB2 receptors in CB2-knockout (CB2-KO) mice also blocked low dose BCP-induced reduction in METH self-administration, suggesting possible involvement of a CB2 receptor mechanism. caryophyllene 86-89 cannabinoid receptor 2 (macrophage) Mus musculus 37-40 34566647-6 2021 Genetic deletion of CB2 receptors in CB2-knockout (CB2-KO) mice also blocked low dose BCP-induced reduction in METH self-administration, suggesting possible involvement of a CB2 receptor mechanism. caryophyllene 86-89 cannabinoid receptor 2 (macrophage) Mus musculus 51-54 34566647-7 2021 However, at high doses, BCP produced a reduction in METH self-administration in CB2-KO mice in a manner similar as in WT mice, suggesting that non-CB2 receptor mechanisms underlie high dose BCP-produced effects. caryophyllene 24-27 cannabinoid receptor 2 (macrophage) Mus musculus 147-150 34125438-12 2021 A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells. caryophyllene 284-287 CD163 molecule Homo sapiens 149-154 34354405-0 2021 beta-Caryophyllene ameliorates the Mycoplasmal pneumonia through the inhibition of NF-kappaB signal transduction in mice. caryophyllene 0-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 145-149 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 heme oxygenase 1 Homo sapiens 150-154 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 adiponectin receptor 1 Homo sapiens 159-166 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 adiponectin receptor 2 Homo sapiens 171-178 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 adiponectin, C1Q and collagen domain containing Homo sapiens 215-226 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 glucagon like peptide 1 receptor Homo sapiens 228-233 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 interferon gamma Homo sapiens 235-244 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 superoxide dismutase 1 Homo sapiens 246-249 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 catalase Homo sapiens 251-259 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 nuclear factor kappa B subunit 1 Homo sapiens 283-292 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 leptin Homo sapiens 294-300 34277815-2 2021 We aimed to investigate the mechanism of the CNR2 agonist (beta-caryophyllene, beta-Car) in regulating the balance of regulatory T cells (Treg) and T helper cell 17 (Th17) and thus its role in asthma. caryophyllene 59-77 cannabinoid receptor 2 (macrophage) Mus musculus 45-49 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 interleukin 4 Homo sapiens 302-306 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 tumor necrosis factor Homo sapiens 308-311 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 interleukin 1 alpha Homo sapiens 317-325 35300975-4 2022 Beta-caryophyllene is a functional CB2 receptor agonist and exhibit a good safety profile. caryophyllene 0-18 cannabinoid receptor 2 Rattus norvegicus 35-47 35550220-0 2022 beta-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats. caryophyllene 0-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 105-109 35550220-0 2022 beta-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 110-114 35550220-3 2022 PURPOSE: This research was to determine the existence of ferroptosis in the pathogenesis of acute ischemic stroke and investigate whether BCP can inhibit ferroptosis to improve cerebral ischemia injury by activating the NRF2/HO-1 signaling pathway in rats. caryophyllene 138-141 NFE2 like bZIP transcription factor 2 Rattus norvegicus 220-224 35550220-3 2022 PURPOSE: This research was to determine the existence of ferroptosis in the pathogenesis of acute ischemic stroke and investigate whether BCP can inhibit ferroptosis to improve cerebral ischemia injury by activating the NRF2/HO-1 signaling pathway in rats. caryophyllene 138-141 heme oxygenase 1 Rattus norvegicus 225-229 35550220-11 2022 We demonstrated that BCP evidently enhanced NRF2 nuclear translocation, activated the NRF2/HO-1 pathway, which protected against ferroptosis. caryophyllene 21-24 NFE2 like bZIP transcription factor 2 Rattus norvegicus 44-48 35550220-11 2022 We demonstrated that BCP evidently enhanced NRF2 nuclear translocation, activated the NRF2/HO-1 pathway, which protected against ferroptosis. caryophyllene 21-24 NFE2 like bZIP transcription factor 2 Rattus norvegicus 86-90 35550220-11 2022 We demonstrated that BCP evidently enhanced NRF2 nuclear translocation, activated the NRF2/HO-1 pathway, which protected against ferroptosis. caryophyllene 21-24 heme oxygenase 1 Rattus norvegicus 91-95 35550220-16 2022 For the first time, we showed that the significant neuroprotective effects of BCP in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis. caryophyllene 78-81 NFE2 like bZIP transcription factor 2 Rattus norvegicus 219-223 35550220-16 2022 For the first time, we showed that the significant neuroprotective effects of BCP in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis. caryophyllene 78-81 heme oxygenase 1 Rattus norvegicus 224-228 35489272-8 2022 P13K-AKT signaling pathway was involved in the reversal of cardiac hypertrophy by the combination of 1,8-cineole and beta-caryophyllene. caryophyllene 117-135 AKT serine/threonine kinase 1 Rattus norvegicus 5-8 35278524-13 2022 CONCLUSIONS: These findings highlight a neuroprotective role of alpha-bisabolol against Abeta-mediated neurotoxicity associated with an inhibition of Abeta fibrillization and modest antioxidant effect against lipid peroxidation, while beta-caryophyllene also provided a small but significant measure of protection to Abeta-mediated neurotoxicity. caryophyllene 235-253 amyloid beta (A4) precursor protein Mus musculus 88-93 35408995-0 2022 Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion. caryophyllene 28-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 35631497-8 2022 Additionally, beta-caryophyllene reduced carrageenan-induced peritonitis, and the molecular modeling and computational simulation predicted the intermolecular interactions in the P2X7R situs. caryophyllene 14-32 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 179-184 35631497-9 2022 In silico, results indicated beta-caryophyllene as a potent allosteric P2X7R antagonist, although this substance may present toxic effects for humans. caryophyllene 29-47 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 71-76 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 102-105 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-163 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 102-105 brain-derived neurotrophic factor Rattus norvegicus 165-169 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 102-105 glial fibrillary acidic protein Rattus norvegicus 228-232 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 102-105 allograft inflammatory factor 1 Rattus norvegicus 237-241 35408995-6 2022 The BCP treatment caused a decrease of BDNF and an increase of trkB levels in both sham and BCCAO/R conditions while inducing opposite changes in the case of TRPV1, whose levels became higher in BCCAO/R and lower in sham conditions. caryophyllene 4-7 brain-derived neurotrophic factor Rattus norvegicus 39-43 35408995-6 2022 The BCP treatment caused a decrease of BDNF and an increase of trkB levels in both sham and BCCAO/R conditions while inducing opposite changes in the case of TRPV1, whose levels became higher in BCCAO/R and lower in sham conditions. caryophyllene 4-7 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 63-67 35621844-0 2022 beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways. caryophyllene 0-18 toll-like receptor 4 Rattus norvegicus 91-95 35621844-0 2022 beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways. caryophyllene 0-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 109-113 35621844-0 2022 beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 114-117 35621844-0 2022 beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways. caryophyllene 0-18 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 118-122 35621844-16 2022 CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses. caryophyllene 12-15 NFE2 like bZIP transcription factor 2 Rattus norvegicus 61-65 35621844-16 2022 CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses. caryophyllene 12-15 heme oxygenase 1 Rattus norvegicus 66-69 35621844-16 2022 CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses. caryophyllene 12-15 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 70-74 35621844-16 2022 CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses. caryophyllene 12-15 toll-like receptor 4 Rattus norvegicus 89-93 35408995-7 2022 Present results highlight the role of BCP in modulating early events of the cerebral inflammation triggered by the BCCAO/R through the regulation of TRPV1 and the BDNF-trkB system. caryophyllene 38-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 149-154 35408995-7 2022 Present results highlight the role of BCP in modulating early events of the cerebral inflammation triggered by the BCCAO/R through the regulation of TRPV1 and the BDNF-trkB system. caryophyllene 38-41 brain-derived neurotrophic factor Rattus norvegicus 163-167 35408995-7 2022 Present results highlight the role of BCP in modulating early events of the cerebral inflammation triggered by the BCCAO/R through the regulation of TRPV1 and the BDNF-trkB system. caryophyllene 38-41 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 168-172 35408995-0 2022 Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion. caryophyllene 28-46 brain-derived neurotrophic factor Rattus norvegicus 85-89 35408995-0 2022 Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion. caryophyllene 28-46 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 94-98 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 82-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-163 35408995-2 2022 Thus in this study, we investigate with immunochemical assays if a single dose of beta-caryophyllene (BCP), administered before the BCCAO/R, can modulate the TRPV1, BDNF, and trkB receptor in the brain cortex; the glial markers GFAP and Iba1 were also examined. caryophyllene 82-100 brain-derived neurotrophic factor Rattus norvegicus 165-169 35154574-7 2022 Biochemical assays revealed the antioxidant and anti-inflammatory mechanisms of the beta-caryophyllene-treated group with increasing levels of IL-10 and GPx and decreasing levels of pro-inflammatory molecules, including TNF-alpha, IFN-gamma, IL-1beta and IL-6. caryophyllene 84-102 interleukin 10 Rattus norvegicus 143-148 35296033-0 2022 The Food Additive beta-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway. caryophyllene 18-36 Janus kinase 2 Rattus norvegicus 84-88 35296033-0 2022 The Food Additive beta-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway. caryophyllene 18-36 signal transducer and activator of transcription 3 Rattus norvegicus 89-94 35296033-0 2022 The Food Additive beta-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway. caryophyllene 18-36 beta-secretase 1 Rattus norvegicus 95-100 35296033-12 2022 In conclusion, inhibition of the "JAK2-STAT3-BACE1" signalling pathway may be one of the mechanisms through which BCP protects neurons and antagonises Abeta"s neurotoxicity. caryophyllene 114-117 Janus kinase 2 Rattus norvegicus 34-38 35296033-12 2022 In conclusion, inhibition of the "JAK2-STAT3-BACE1" signalling pathway may be one of the mechanisms through which BCP protects neurons and antagonises Abeta"s neurotoxicity. caryophyllene 114-117 signal transducer and activator of transcription 3 Rattus norvegicus 39-44 35296033-12 2022 In conclusion, inhibition of the "JAK2-STAT3-BACE1" signalling pathway may be one of the mechanisms through which BCP protects neurons and antagonises Abeta"s neurotoxicity. caryophyllene 114-117 beta-secretase 1 Rattus norvegicus 45-50 35068213-10 2022 Both BCP regimens ameliorated renal functions and histology, and reduced NF-kappaB, TGF-beta, and KIM-1 levels in addition to those of oxidative stress and inflammation markers. caryophyllene 5-8 transforming growth factor alpha Rattus norvegicus 84-92 35068213-10 2022 Both BCP regimens ameliorated renal functions and histology, and reduced NF-kappaB, TGF-beta, and KIM-1 levels in addition to those of oxidative stress and inflammation markers. caryophyllene 5-8 hepatitis A virus cellular receptor 1 Rattus norvegicus 98-103 35154574-8 2022 After beta-caryophyllene treatment, immunohistochemical assays showed enhanced re-epithelialization, through the increase in laminin-gamma2 and desmoglein-3 immunolabeling. caryophyllene 6-24 desmoglein 3 Rattus norvegicus 144-156 35154574-7 2022 Biochemical assays revealed the antioxidant and anti-inflammatory mechanisms of the beta-caryophyllene-treated group with increasing levels of IL-10 and GPx and decreasing levels of pro-inflammatory molecules, including TNF-alpha, IFN-gamma, IL-1beta and IL-6. caryophyllene 84-102 tumor necrosis factor Rattus norvegicus 220-229 35154574-7 2022 Biochemical assays revealed the antioxidant and anti-inflammatory mechanisms of the beta-caryophyllene-treated group with increasing levels of IL-10 and GPx and decreasing levels of pro-inflammatory molecules, including TNF-alpha, IFN-gamma, IL-1beta and IL-6. caryophyllene 84-102 interferon gamma Rattus norvegicus 231-240 35154574-7 2022 Biochemical assays revealed the antioxidant and anti-inflammatory mechanisms of the beta-caryophyllene-treated group with increasing levels of IL-10 and GPx and decreasing levels of pro-inflammatory molecules, including TNF-alpha, IFN-gamma, IL-1beta and IL-6. caryophyllene 84-102 interleukin 1 alpha Rattus norvegicus 242-250 35154574-7 2022 Biochemical assays revealed the antioxidant and anti-inflammatory mechanisms of the beta-caryophyllene-treated group with increasing levels of IL-10 and GPx and decreasing levels of pro-inflammatory molecules, including TNF-alpha, IFN-gamma, IL-1beta and IL-6. caryophyllene 84-102 interleukin 6 Rattus norvegicus 255-259 35154574-8 2022 After beta-caryophyllene treatment, immunohistochemical assays showed enhanced re-epithelialization, through the increase in laminin-gamma2 and desmoglein-3 immunolabeling. caryophyllene 6-24 laminin subunit gamma 2 Rattus norvegicus 125-139 33967792-0 2021 beta-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-kappaB Signal Pathway: In Silico and In Vivo. caryophyllene 0-18 NLR family, pyrin domain containing 3 Rattus norvegicus 95-100 35056767-5 2022 Applying our novel algorithm toolset-MCCS, we docked three known AMs of CB2 including Ec2la (C-2), trans-beta-caryophyllene (TBC) and cannabidiol (CBD) to each site for further comparisons and quantified the potential binding residues in each allosteric binding site. caryophyllene 99-123 cannabinoid receptor 2 Homo sapiens 72-75 35056767-5 2022 Applying our novel algorithm toolset-MCCS, we docked three known AMs of CB2 including Ec2la (C-2), trans-beta-caryophyllene (TBC) and cannabidiol (CBD) to each site for further comparisons and quantified the potential binding residues in each allosteric binding site. caryophyllene 125-128 cannabinoid receptor 2 Homo sapiens 72-75 35092394-12 2022 CNR2 was the notable target of beta-caryophyllene and performed agonistic interaction, which might have contributed to its cytotoxic activity against 4T1 cells. caryophyllene 31-49 cannabinoid receptor 2 (macrophage) Mus musculus 0-4 24309966-3 1985 The secretion from the first abdominal gland consists of a mixture of C10 and C15 isoprenoids: (C10) alpha-pinene, beta-pinene, limonene, beta-phellandrene; (C15) beta-caryophyllene, caryophyllene oxide, alpha-humulene, and (the major component) humulene epoxide II. caryophyllene 163-181 placenta associated 8 Homo sapiens 158-161 33981431-8 2021 The analysis of TNF-alpha expression revealed improved results in trans-caryophyllene animals. caryophyllene 66-85 tumor necrosis factor Rattus norvegicus 16-25 33981431-11 2021 Treatment with trans-caryophyllene modulated serum IFN-gamma levels negatively, whereas treatment with atorvastatin and trans-caryophyllene maintained lower levels of IFN-gamma compared with the control group. caryophyllene 15-34 interferon gamma Rattus norvegicus 51-60 33981431-11 2021 Treatment with trans-caryophyllene modulated serum IFN-gamma levels negatively, whereas treatment with atorvastatin and trans-caryophyllene maintained lower levels of IFN-gamma compared with the control group. caryophyllene 120-139 interferon gamma Rattus norvegicus 167-176 34054510-7 2021 To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. caryophyllene 91-109 cannabinoid receptor 2 Homo sapiens 34-37 34054510-7 2021 To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. caryophyllene 111-114 cannabinoid receptor 2 Homo sapiens 34-37