PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10517009-3	1999	An efficient and stereoselective synthesis of the C13-C23 part (8) was achieved starting from methyl (R)- and (S)-3-hydroxy-2-methylpropionates (9) via coupling of the C13-C17 aldehyde (6), prepared by Evans asymmetric aldol reaction, with the C18-C21 iodoalkene (5b) by taking advantage of the 3,4-dimethoxybenzyl protecting group.	r)	102-104	homeobox C13	Homo sapiens	50-53
10517009-3	1999	An efficient and stereoselective synthesis of the C13-C23 part (8) was achieved starting from methyl (R)- and (S)-3-hydroxy-2-methylpropionates (9) via coupling of the C13-C17 aldehyde (6), prepared by Evans asymmetric aldol reaction, with the C18-C21 iodoalkene (5b) by taking advantage of the 3,4-dimethoxybenzyl protecting group.	r)	102-104	nucleolin	Homo sapiens	54-57
32122740-4	2020	The results of enzymatic activity assays supported compound 16m-(R) as a potential and selective JAK2 inhibitor, which exhibited high inhibitory activity with an IC50 of 3 nM against JAK2, and 85- and 76-fold selectivity over JAK1 and JAK3, respectively.	r)	65-67	Janus kinase 2	Homo sapiens	97-101
3838477-4	1985	On the other hand, [23 (S),25 (R)]-1 alpha,25-(OH)2D3-26,23-lactone decreased slightly but significantly 45Ca mobilization, and blocked the resorptive action of 1 alpha,25-dihydroxyvitamin D3 but not that of parathyroid hormone, in mouse calvaria in organ culture.	r)	31-33	parathyroid hormone	Mus musculus	208-227
32122740-4	2020	The results of enzymatic activity assays supported compound 16m-(R) as a potential and selective JAK2 inhibitor, which exhibited high inhibitory activity with an IC50 of 3 nM against JAK2, and 85- and 76-fold selectivity over JAK1 and JAK3, respectively.	r)	65-67	Janus kinase 2	Homo sapiens	183-187
32122740-4	2020	The results of enzymatic activity assays supported compound 16m-(R) as a potential and selective JAK2 inhibitor, which exhibited high inhibitory activity with an IC50 of 3 nM against JAK2, and 85- and 76-fold selectivity over JAK1 and JAK3, respectively.	r)	65-67	Janus kinase 1	Homo sapiens	226-230
32122740-4	2020	The results of enzymatic activity assays supported compound 16m-(R) as a potential and selective JAK2 inhibitor, which exhibited high inhibitory activity with an IC50 of 3 nM against JAK2, and 85- and 76-fold selectivity over JAK1 and JAK3, respectively.	r)	65-67	Janus kinase 3	Homo sapiens	235-239
23993328-3	2013	In the cytotoxic evaluation, compound (R)-10b effectively inhibited the proliferation of c-Met addictive human cancer cell lines (IC50 from 0.19 to 0.71muM) and c-Met activation-mediated cell metastasis.	r)	39-41	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	89-94
25136132-4	2014	Chemoproteomics experiments using a biotinylated derivative of (R)-PFI-2 demonstrated dose-dependent competition for binding to endogenous SETD7 in MCF7 cells pretreated with (R)-PFI-2.	r)	64-66	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	139-144
29959229-8	2018	Using an Rpl29 methylation-specific antibody, we demonstrate that Rpl29K5 methylation is present ubiquitously and validate that (R)-PFI-2, a Set7/9 inhibitor, efficiently reduces Rpl29K5 methylation in cell lines.	r)	129-131	ribosomal protein L29	Homo sapiens	9-14
29959229-8	2018	Using an Rpl29 methylation-specific antibody, we demonstrate that Rpl29K5 methylation is present ubiquitously and validate that (R)-PFI-2, a Set7/9 inhibitor, efficiently reduces Rpl29K5 methylation in cell lines.	r)	129-131	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	141-147
28315263-7	2017	The interactions of (S)-13 and (R)-13 with the sigma1 receptor were analyzed at the molecular level using the 3D homology model.	r)	32-34	sigma non-opioid intracellular receptor 1	Mus musculus	47-62
25423293-5	2014	Strong binding of recombinant (r) AtACBP6 with long-chain acyl-CoA (C16- to C18-CoA) esters was observed with dissociation constants in the nanomolar range.	r)	31-33	acyl-CoA-binding protein 6	Arabidopsis thaliana	34-41
23993328-3	2013	In the cytotoxic evaluation, compound (R)-10b effectively inhibited the proliferation of c-Met addictive human cancer cell lines (IC50 from 0.19 to 0.71muM) and c-Met activation-mediated cell metastasis.	r)	39-41	latexin	Homo sapiens	152-155
23993328-3	2013	In the cytotoxic evaluation, compound (R)-10b effectively inhibited the proliferation of c-Met addictive human cancer cell lines (IC50 from 0.19 to 0.71muM) and c-Met activation-mediated cell metastasis.	r)	39-41	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	161-166
21881950-8	2012	In addition, a statistically significant acute lap effect on C(r) was observed at the end of the second and third laps (by 11.4 and 7.2%, respectively).	r)	63-65	LAP	Homo sapiens	47-50
15709774-4	2005	The similar yields of [1(R)-(2)H]-DHAP and [2(R)-(2)H]-GAP from partitioning of the enzyme-bound enediol(ate) intermediate between hydron transfer to C-1 and C-2 is consistent with earlier results, which showed that there are similar barriers for conversion of this intermediate to the alpha-hydroxy ketone and aldehyde products (Knowles, J. R., and Albery, W. J.	r)	25-27	complement C2	Oryctolagus cuniculus	150-161
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	r)	104-106	apolipoprotein E	Homo sapiens	18-22
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	r)	104-106	ATP binding cassette subfamily A member 1	Homo sapiens	27-32
15041462-6	2004	In contrast, with EPA as substrate CYP1A1 was mainly an epoxygenase, oxidizing with over 68% of total metabolites EPA to 17(R),18(S)-epoxyeicosatetraenoic acid (17(R),18(S)-EETeTr).	r)	124-126	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-41