PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18464997-1	2008	The strongest gas-phase MP2/6-31G*(0.25) stacking energies between the aromatic amino acids and the natural or methylated nucleobases were considered.	nucleobases	122-133	tryptase pseudogene 1	Homo sapiens	24-27
19291308-1	2009	BACKGROUND: Uridine phosphorylase (UPP) is a key enzyme of pyrimidine salvage pathways, catalyzing the reversible phosphorolysis of ribosides of uracil to nucleobases and ribose 1-phosphate.	nucleobases	155-166	uridine phosphorylase 1	Homo sapiens	12-33
19291308-1	2009	BACKGROUND: Uridine phosphorylase (UPP) is a key enzyme of pyrimidine salvage pathways, catalyzing the reversible phosphorolysis of ribosides of uracil to nucleobases and ribose 1-phosphate.	nucleobases	155-166	uridine phosphorylase 1	Homo sapiens	35-38
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	nucleobases	157-168	solute carrier family 29 member 3	Homo sapiens	55-62
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	nucleobases	157-168	solute carrier family 29 member 3	Homo sapiens	200-205
19382793-1	2009	The O, N, and C 1s core level photoemission spectra of the nucleobases cytosine and uracil have been measured in the vapor phase, and the results have been interpreted via theoretical calculations.	nucleobases	59-70	complement C1s	Homo sapiens	14-18
18668437-6	2008	The best-characterized members of the family, hENT1 and hENT2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases.	nucleobases	185-196	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
18668437-6	2008	The best-characterized members of the family, hENT1 and hENT2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases.	nucleobases	185-196	solute carrier family 29 member 2	Homo sapiens	56-61
18668437-6	2008	The best-characterized members of the family, hENT1 and hENT2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases.	nucleobases	185-196	solute carrier family 29 member 2	Homo sapiens	151-156
18668437-7	2008	hENT3 has a similar broad permeant selectivity for nucleosides and nucleobases and appears to function in intracellular membranes, including lysosomes.	nucleobases	67-78	solute carrier family 29 member 3	Homo sapiens	0-5
17955979-2	2007	Milk contains a complex mixture of nucleotides, nucleosides, and nucleobases, and because of the reported differences in their relative levels in bovine and human milks, pediatric formulas are increasingly supplemented with nucleotides.	nucleobases	65-76	Weaning weight-maternal milk	Bos taurus	0-4
17998292-3	2008	Here, we report the functional consequences of molecular substitutions of A9 and A10, two highly conserved nucleobases located adjacent to the hairpin ribozyme active site, using G, C, U, 2-aminopurine, 2,6-diaminopurine, purine, and inosine.	nucleobases	107-118	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	81-84
17655363-12	2007	We hypothesize that AAG may cleave certain damaged nucleobases as anions and that the active site may take advantage of a nonpolar environment to favor deprotonated hypoxanthine as a leaving group versus deprotonated adenine or guanine.	nucleobases	51-62	N-methylpurine DNA glycosylase	Homo sapiens	20-23
17447808-1	2007	Redox potentials for the DNA nucleobases and nucleosides, various relevant nucleoside analogues, Watson-Crick base pairs, and seven organic dyes are presented based on DFT/B3LYP/6-31++G(d,p) and B3YLP/6-311+G(2df,p)//B3LYP/6-31+G* levels of calculations.	nucleobases	29-40	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	174-177
17497910-10	2007	Overall, quantum chemical calculations suggest that the contrasting selectivity of Mg2+ and Mn2+ cofactors toward nucleobases derives from the larger flexibility of the Mn2+ complexes accompanied by the excessive polarization and charge-transfer effects as well as less favorable solvation.	nucleobases	114-125	mucin 7, secreted	Homo sapiens	83-86
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	nucleobases	87-98	equilibrative nucleoside transporter 2	Rattus norvegicus	6-44
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	nucleobases	87-98	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	46-51
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	nucleobases	87-98	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	47-51
17473446-2	2007	Human and rat equilibrative nucleoside transporter 2 (hENT2 and rENT2, respectively) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	nucleobases	171-182	equilibrative nucleoside transporter 2	Rattus norvegicus	14-52
17473446-2	2007	Human and rat equilibrative nucleoside transporter 2 (hENT2 and rENT2, respectively) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	nucleobases	171-182	solute carrier family 29 member 2	Homo sapiens	54-59
17473446-3	2007	In the present study, we characterized the transport of a variety of nucleosides and nucleobases via recombinant mouse ENT2 (mENT2).	nucleobases	85-96	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	119-123
17473446-3	2007	In the present study, we characterized the transport of a variety of nucleosides and nucleobases via recombinant mouse ENT2 (mENT2).	nucleobases	85-96	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	125-130
17473446-5	2007	The mENT2-mediated uptake of adenosine was significantly inhibited by nucleosides and nucleobases, irrespective of purine and pyrimidine.	nucleobases	86-97	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	4-9
16990941-4	2006	Selective syn photoproduct formation and concomitant suppression of the trans isomer are favored by orientation of the two guest nucleobases within the template cleft.	nucleobases	129-140	synemin	Homo sapiens	10-13
17088032-3	2007	Equilibrative nucleoside transporter 2 (ENT2) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	nucleobases	132-143	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	40-44
15561147-2	2004	The ability of dCK to degrade 2"-deoxyribonucleosides to free nucleobases and 2-deoxy-alpha-d-ribofuranose-1-phosphate was demonstrated by 1H-31P correlation spectroscopy and by isotope enzyme kinetic methods.	nucleobases	62-73	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	15-18
17723339-4	2006	While the sensing functions depend on the flanking sequences to the AP site, Vitamin B2 is applicable to the detection of T/C (cytosine), T/G (guanine) and T/A (adenine) mutation sequences of the CYP2A6 gene, where the flanking nucleobases are guanines in both positions (-GXG-, X=AP site).	nucleobases	228-239	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	196-202
16228642-1	2005	To explore how chemical structures of both nucleobases and amino acids may have played a role in shaping the genetic code, numbers of sp2 hybrid nitrogen atoms in nucleobases were taken as a determinative measure for empirical stereo-electronic property to analyze the genetic code.	nucleobases	163-174	Sp2 transcription factor	Homo sapiens	134-137
16228642-2	2005	Results revealed that amino acid hydropathy correlates strongly with the sp2 nitrogen atom numbers in nucleobases rather than with the overall electronic property such as redox potentials of the bases, reflecting that stereo-electronic property of bases may play a role.	nucleobases	102-113	Sp2 transcription factor	Homo sapiens	73-76
16984202-3	2006	Human thymine DNA glycosylase (hTDG) cleaves thymine from mutagenic G.T mispairs, recognizes many additional lesions, and has a strong preference for nucleobases paired with guanine rather than adenine.	nucleobases	150-161	thymine DNA glycosylase	Homo sapiens	6-29
16984202-3	2006	Human thymine DNA glycosylase (hTDG) cleaves thymine from mutagenic G.T mispairs, recognizes many additional lesions, and has a strong preference for nucleobases paired with guanine rather than adenine.	nucleobases	150-161	thymine DNA glycosylase	Homo sapiens	31-35
15371014-3	2004	These transporters resemble their human counterparts hENT1 and hENT2 in exhibiting similar broad permeant specificities for nucleosides, while differing in their permeant selectivities for nucleobases.	nucleobases	189-200	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	53-58
15371014-3	2004	These transporters resemble their human counterparts hENT1 and hENT2 in exhibiting similar broad permeant specificities for nucleosides, while differing in their permeant selectivities for nucleobases.	nucleobases	189-200	solute carrier family 29 member 2	Homo sapiens	63-68
11980562-2	2002	LAPTM4 alpha functions to regulate the intracellular compartmentalization of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations.	nucleobases	183-194	lysosomal protein transmembrane 4 alpha	Homo sapiens	0-12
12838422-4	2004	The best-characterised members of the family, hENT1 and hENT2, possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases.	nucleobases	193-204	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
12838422-4	2004	The best-characterised members of the family, hENT1 and hENT2, possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases.	nucleobases	193-204	solute carrier family 29 member 2	Homo sapiens	56-61
12838422-4	2004	The best-characterised members of the family, hENT1 and hENT2, possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases.	nucleobases	193-204	solute carrier family 29 member 2	Homo sapiens	152-157
12810710-13	2003	In competition experiments, the transport of [3H]adenosine by AtENT3 was most significantly inhibited by a number of different purine and pyrimidine nucleosides and 2"-deoxynucleosides, although certain nucleobases and nucleotides were also found to have some inhibitory effect.	nucleobases	203-214	Major facilitator superfamily protein	Arabidopsis thaliana	62-68
11329272-13	2001	These findings raise the possibility that halogenated nucleobases generated by eosinophil peroxidase exert cytotoxic and mutagenic effects at eosinophil-rich sites of inflammation.	nucleobases	54-65	eosinophil peroxidase	Homo sapiens	79-100
12110519-2	2002	In the present work, we studied the substrate specificities of the human and rat orthologs of the Na+-dependent purine-selective nucleoside transporter (SPNT; concentrative nucleoside transporter 2), for nucleosides, nucleobases, and base- and ribose-modified nucleoside analogs.	nucleobases	217-228	solute carrier family 28 member 2	Rattus norvegicus	153-157
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	nucleobases	312-323	solute carrier family 29 member 2	Homo sapiens	99-104
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	nucleobases	312-323	purine-cytosine permease	Saccharomyces cerevisiae S288C	143-147
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	nucleobases	312-323	epsin	Saccharomyces cerevisiae S288C	100-104
11788733-7	2002	Previously, liquid chromatography of the nucleobases has been problematic but is made possible by low-temperature reverse-phase C18 chromatography, a method that increases retention on the column.	nucleobases	41-52	Bardet-Biedl syndrome 9	Homo sapiens	128-131
12440703-3	2002	Recent studies of hENT2 produced in recombinant form in functional expression systems have shown that it differs from hENT1 in that it transports nucleobases.	nucleobases	146-157	solute carrier family 29 member 2	Homo sapiens	18-23
12440703-3	2002	Recent studies of hENT2 produced in recombinant form in functional expression systems have shown that it differs from hENT1 in that it transports nucleobases.	nucleobases	146-157	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	118-123
11139404-1	2001	The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transport of nucleobases and sensitivity to inhibition by nitrobenzylthioinosine (NBMPR) and vasoactive drugs.	nucleobases	257-268	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	64-69
11139404-1	2001	The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transport of nucleobases and sensitivity to inhibition by nitrobenzylthioinosine (NBMPR) and vasoactive drugs.	nucleobases	257-268	solute carrier family 29 member 1	Rattus norvegicus	71-76
11139404-1	2001	The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transport of nucleobases and sensitivity to inhibition by nitrobenzylthioinosine (NBMPR) and vasoactive drugs.	nucleobases	257-268	solute carrier family 29 member 2	Homo sapiens	78-83
11396612-4	2001	Whilst the name of the family reflects the properties of its prototypical member hENT1, an equilibrative transporter of nucleosides, some family members can also transport nucleobases and some are proton-dependent, concentrative transporters.	nucleobases	172-183	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	81-86
11179696-7	2001	CEM/C19 cells stably expressing mENT1.1 and mENT1.2 show similar dose response curves for NBMPR and dipyridamole inhibition of [(3)H]adenosine uptake as well as exhibiting comparable selectivity for both purine and pyrimidine nucleosides but not the corresponding nucleobases.	nucleobases	264-275	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	32-37
11179696-7	2001	CEM/C19 cells stably expressing mENT1.1 and mENT1.2 show similar dose response curves for NBMPR and dipyridamole inhibition of [(3)H]adenosine uptake as well as exhibiting comparable selectivity for both purine and pyrimidine nucleosides but not the corresponding nucleobases.	nucleobases	264-275	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	44-49
10499110-0	1999	Reactivity of an extremely sterically crowded monofunctional Pt complex, [Pt(1-MeC-N3)3(H2O)]2+ (1-MeC = 1-methylcytosine), toward model nucleobases and selectivity toward guanine in single- and double-stranded deoxyoligonucleotides.	nucleobases	137-148	C-C motif chemokine ligand 28	Homo sapiens	79-82
10827169-4	2000	FUI1 transported uridine with high affinity (K(m), 22 +/- 3 micrometer) and was unaffected or inhibited only partially by high concentrations (1 mm) of a variety of ribo- and deoxyribonucleosides or nucleobases.	nucleobases	199-210	uridine permease	Saccharomyces cerevisiae S288C	0-4
10631088-5	2000	SVCT1 displays exquisite substrate selectivity, greatly favoring l-ascorbic acid over its isomers d-isoascorbic acid and dehydroascorbic acid and 2- or 6-substituted analogues, whereas glucose and nucleobases are excluded.	nucleobases	197-208	solute carrier family 23 member 1	Homo sapiens	0-5
10542226-2	1999	Herpes simplex virus type 1 (HSV 1) thymidine kinase (TK) exhibits an extensive substrate diversity for nucleobases and sugar moieties, in contrast to other TKs.	nucleobases	104-115	involved in nucleotide metabolism	Human alphaherpesvirus 1	36-52
10542226-2	1999	Herpes simplex virus type 1 (HSV 1) thymidine kinase (TK) exhibits an extensive substrate diversity for nucleobases and sugar moieties, in contrast to other TKs.	nucleobases	104-115	involved in nucleotide metabolism	Human alphaherpesvirus 1	54-56
10407144-7	1999	(d) The specific interactions that occur between GAPDH and the tRNA(Phe) involve, mainly, stacking between nucleobases and aromatic amino-acid residues, and ionic interactions of basic amino-acid residues with phosphate groups of the ribose-phosphate backbone.	nucleobases	107-118	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	49-54
9464364-6	1998	The reactivity of the complex to model nucleobases 9-ethylguanine (9-EtGH) and 1-methylcytosine (1-MeC) has been investigated by 1H NMR spectroscopy at 45 degrees C in aqueous media.	nucleobases	39-50	C-C motif chemokine ligand 28	Homo sapiens	99-102
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	nucleobases	185-196	thiopurine S-methyltransferase	Homo sapiens	0-30
18966682-2	1996	A molecular ion is clearly observed in both spectra, but the efficiency is improved 10-fold when a femtosecond laser is used, indicating the distinct advantage of ultrashort laser pulses for multiphoton ionization of nucleobases in supersonic jet spectrometry.	nucleobases	217-228	F-box and leucine rich repeat protein 15	Homo sapiens	243-246
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	nucleobases	185-196	thiopurine S-methyltransferase	Homo sapiens	32-36
1544389-1	1992	At suboptimal concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF), nucleobases and nucleosides as well as their analogues strongly stimulated aggregate (colony and cluster) formation from murine bone marrow granulocyte-macrophage colony-forming units (CFU-GM) in agar culture.	nucleobases	91-102	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	32-80
8724854-2	1995	IFN-alpha treatment influenced the metabolism of exogenously supplied nucleobases and nucleosides in a manner expected to contribute to synergistic activity.	nucleobases	70-81	interferon alpha 1	Homo sapiens	0-9
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	nucleobases	57-68	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	10-15
33753838-3	2021	The spectroscopic analysis of the archaeological textiles by SERS reveals the presence of bands attributed to carminic acid and nucleobases, mainly adenine and guanine.	nucleobases	128-139	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	61-65
6487743-3	1984	Values of amino pKD fall in the range 8.6-9.4 for the unsubstituted nucleobases and their endocyclic N-methylated derivatives.	nucleobases	68-79	protein kinase D1	Homo sapiens	16-19
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	nucleobases	57-68	solute carrier family 29 member 2	Homo sapiens	20-25
32095808-8	2020	Site specific structural changes induced by stacking of the pyrene moiety on nearby nucleobases corelate with distinct thrombin binding affinities and increased resistance against nuclease degradation.	nucleobases	84-95	coagulation factor II, thrombin	Homo sapiens	119-127
31283918-7	2019	The transgenic strains are capable of transporting nucleobases that are substrates of rSNBT1 but also of the endogenous L. tarentolae nucleoside/nucleobase transporters.	nucleobases	51-62	similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2)	Rattus norvegicus	86-92
32153630-2	2020	NT5C2 gene (OMIM: 600417) encode a hydrolase enzyme 5"-nucleotidase, cytosolic II play an important role in maintaining the balance of purine nucleotides and free nucleobases in the spinal cord and brain.	nucleobases	163-174	5'-nucleotidase, cytosolic II	Homo sapiens	0-5
30869082-3	2019	Experimentally, we unequivocally demonstrate that the Franck-Condon excited states of d(GpT) are significantly delocalised across both nucleobases, and mediate d(G+pT-) exciplex product formation on an ultrafast (<350 fs) timescale.	nucleobases	135-146	glutamic--pyruvic transaminase	Homo sapiens	88-91
30409785-6	2019	Overall, we provide evidence derived from X-ray structures that nucleobases are poor inner-sphere binders for Mg2+ but good binders for monovalent ions.	nucleobases	64-75	mucin 7, secreted	Homo sapiens	110-113
30605331-8	2019	Thus, we identified, and characterized in vivo, ribose and methanocarba nucleosides, including with A1AR-enhancing N6-dicyclobutylmethyl-adenine and 1,2,4-triazole-3-carboxamide (40, MRS7451) nucleobases.	nucleobases	192-203	adenosine A1 receptor	Mus musculus	100-104
30088497-6	2018	Our results show that majority of the Mg2+ bound nucleobases are also part of a base pair.	nucleobases	49-60	mucin 7, secreted	Homo sapiens	38-41
29076432-2	2018	The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases.	nucleobases	105-116	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-8
29989830-3	2018	When incorporated into duplex DNA, 4CIN pairs equivalently with native nucleobases and has uniquely high quantum yields ranging from 0.15 to 0.31 depending on sequence and hybridization contexts, surpassing that of 2-aminopurine, the prototypical nucleoside fluorophore.	nucleobases	71-82	pyridoxal phosphatase	Homo sapiens	36-39
26778611-0	2016	Three new double-headed nucleotides with additional nucleobases connected to C-5 of pyrimidines; synthesis, duplex and triplex studies.	nucleobases	52-63	complement C5	Homo sapiens	77-80
28430443-10	2017	From the AIM, NCI-RDG, and EDA results, we conclude that noncovalent and electrostatic interaction with partial covalent character exists in the intermolecular bonding between the host and the guest nucleobases.	nucleobases	199-210	ectodysplasin A	Homo sapiens	27-30
27805810-4	2016	Together with previous structural and biochemical findings, the results illustrate how TDG employs an adaptable active site to excise a broad variety of nucleobases from DNA.	nucleobases	153-164	thymine DNA glycosylase	Homo sapiens	87-90
26765542-1	2016	Human alkyladenine DNA glycosylase (AAG) functions as part of the base excision repair (BER) pathway by cleaving the N-glycosidic bond that connects nucleobases to the sugar-phosphate backbone in DNA.	nucleobases	149-160	N-methylpurine DNA glycosylase	Homo sapiens	6-34
26765542-1	2016	Human alkyladenine DNA glycosylase (AAG) functions as part of the base excision repair (BER) pathway by cleaving the N-glycosidic bond that connects nucleobases to the sugar-phosphate backbone in DNA.	nucleobases	149-160	N-methylpurine DNA glycosylase	Homo sapiens	36-39
28708927-1	2017	The prebiotic synthesis of canonical nucleobases from HCN is a cornerstone for the RNA world hypothesis.	nucleobases	37-48	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	54-57
28657627-2	2017	Computational (DFT and MD simulation) methods are employed to systematically characterize the structural and energetic properties of five hydrophobic nucleobases (FEMO, MMO2, NaM, 5SICS and TPT3) that constitute four unnatural base pairs (FEMO:5SICS, MMO2:5SICS, NaM:5SICS and TPT3:NaM).	nucleobases	150-161	SH3 and cysteine rich domain 3	Homo sapiens	175-178
28657627-2	2017	Computational (DFT and MD simulation) methods are employed to systematically characterize the structural and energetic properties of five hydrophobic nucleobases (FEMO, MMO2, NaM, 5SICS and TPT3) that constitute four unnatural base pairs (FEMO:5SICS, MMO2:5SICS, NaM:5SICS and TPT3:NaM).	nucleobases	150-161	SH3 and cysteine rich domain 3	Homo sapiens	263-266
28657627-2	2017	Computational (DFT and MD simulation) methods are employed to systematically characterize the structural and energetic properties of five hydrophobic nucleobases (FEMO, MMO2, NaM, 5SICS and TPT3) that constitute four unnatural base pairs (FEMO:5SICS, MMO2:5SICS, NaM:5SICS and TPT3:NaM).	nucleobases	150-161	SH3 and cysteine rich domain 3	Homo sapiens	263-266
28130641-6	2017	Theoretical analysis based on MP2 and DFT shows that the interaction between the serine and nucleobases is mainly determined by hydrogen bonding.	nucleobases	92-103	tryptase pseudogene 1	Homo sapiens	30-33
28077982-5	2016	Using both the SEHRS and SERS data, a comprehensive vibrational characterization of the interaction of nucleobases with silver nanostructures can be achieved.	nucleobases	103-114	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	25-29
26163994-2	2015	ENT3 is a member of the equilibrative nucleoside transporter (ENT) family whose primary function is mediating transport of nucleosides and nucleobases.	nucleobases	139-150	solute carrier family 29 member 3	Homo sapiens	0-4
25135661-6	2014	Furthermore, the transport of nucleobases was markedly inhibited by low concentrations of a proton uncoupler indicating that NAT3 and NAT12 act as proton-nucleobase symporters.	nucleobases	30-41	Xanthine/uracil permease family protein	Arabidopsis thaliana	125-129
25870268-5	2015	In accordance with theoretical studies, the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN ) for the synthesis of nucleobases.	nucleobases	187-198	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	57-60
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	nucleobases	217-228	mitochondrial amidoxime reducing component 1	Homo sapiens	29-79
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	nucleobases	217-228	mitochondrial amidoxime reducing component 2	Mus musculus	81-86
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	nucleobases	217-228	mitochondrial amidoxime reducing component 2	Mus musculus	91-96
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	nucleobases	217-228	cytochrome b5 type A	Homo sapiens	302-315
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	nucleobases	217-228	cytochrome b5 type A	Homo sapiens	325-338
25611676-2	2015	Cyclic voltammetry (CV), electrochemically controlled scanning tunneling microscopy (EC-STM), and density functional theory (DFT) calculations have been employed in the present study to address the adsorption of the four nucleobases adenine (A), cytosine (C), guanine (G), and thymine (T), on the Au(110)-electrode surface.	nucleobases	221-232	sulfotransferase family 1A member 3	Homo sapiens	88-91
26080001-9	2015	For the first time the binding of nucleobases was observed for AtENT7.	nucleobases	34-45	equilibrative nucleoside transporter 7	Arabidopsis thaliana	63-69
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	nucleobases	143-154	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	39-44
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	nucleobases	143-154	solute carrier family 29 member 2	Homo sapiens	49-54
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	nucleobases	143-154	solute carrier family 29 member 2	Homo sapiens	178-183
25135661-6	2014	Furthermore, the transport of nucleobases was markedly inhibited by low concentrations of a proton uncoupler indicating that NAT3 and NAT12 act as proton-nucleobase symporters.	nucleobases	30-41	nucleobase-ascorbate transporter 12	Arabidopsis thaliana	134-139
25340302-1	2014	Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5"-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing.	nucleobases	260-271	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
24911289-12	2014	This effect is due to the Watson-Crick H-bonds, which are absent in the {GpT+water} system and restrain the relative positioning of the reactive nucleobases in DNA.	nucleobases	145-156	glutamic--pyruvic transaminase	Homo sapiens	73-76
25122757-7	2014	Unlike other AlkB family members whose substrates are DNA or RNA, ALKBH7 is devoid of the "nucleotide recognition lid" which is essential for binding nucleobases, and thus exhibits a solvent-exposed active site; two loops between beta-strands beta6 and beta7 and between beta9 and beta10 create a special outer wall of the minor beta-sheet of the double-stranded beta-helix and form a negatively charged groove.	nucleobases	150-161	alkB homolog 7	Homo sapiens	66-72
25192494-3	2014	Formamide, a hydrolysis product of HCN, was taken as starting material for the formation of nucleobases.	nucleobases	92-103	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	35-38
23512694-4	2013	Complete removal of the nucleobases, phosphates, and 2"-O-tert-butyldimethylsilyl protecting groups leads to the desired propargylated c-di-GMP diester.	nucleobases	24-35	5'-nucleotidase, cytosolic II	Homo sapiens	140-143
24410629-2	2014	The major event of the mechanism of their mutagenicity is N-hydroxylation by P450 enzymes, primarily P450 1A2 (CYP1A2), which leads to the formation of nitrenium ions that covalently modify nucleobases of DNA.	nucleobases	190-201	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	111-117
24086629-1	2013	Aquaporin-9 (AQP9) is a membrane protein channel that is permeable to a range of small solutes, including glycerol, urea and nucleobases.	nucleobases	125-136	aquaporin 9	Homo sapiens	0-11
24086629-1	2013	Aquaporin-9 (AQP9) is a membrane protein channel that is permeable to a range of small solutes, including glycerol, urea and nucleobases.	nucleobases	125-136	aquaporin 9	Homo sapiens	13-17
23658065-0	2013	Adenine phosphoribosyl transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis.	nucleobases	90-101	adenine phosphoribosyl transferase 1	Arabidopsis thaliana	0-36
24858469-1	2014	A new hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica (Sil-VOX(n)) phase was synthesized and applied for the separation of nucleosides and nucleobases in hydrophilic interaction chromatography (HILIC).	nucleobases	154-165	STIL centriolar assembly protein	Homo sapiens	70-73
24715469-2	2014	It has been known for decades that the radiolysis of HCN solutions produces sugars, amino acids and nucleobases.	nucleobases	100-111	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	53-56
21739554-10	2011	More importantly, changes observed in nucleobases, which are indicative of DNA/RNA-protein binding interactions, suggest transcription deregulations as participating precursor onsets of different transport mechanisms that lead to Hsp70 differential expression and associated phenotypic variation.	nucleobases	38-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	230-235
22924387-4	2012	Here, we demonstrate the reductive detoxification of toxic and mutagenic N-hydroxylated nucleobases and their corresponding nucleosides by the mammalian mARC-containing enzyme system.	nucleobases	88-99	activity regulated cytoskeletal-associated protein	Mus musculus	153-157
22127869-8	2012	SELEX (Systematic evolution of ligands by exponential enrichment) and nucleobase preference assays determined the nucleobases with high affinity for HCF152 and suggested several characteristic amino acids that may be involved in determining specificity and/or affinity of the PPR/RNA interaction.	nucleobases	114-125	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	149-155
23097742-1	2012	The nucleobase-ascorbate transporter or nucleobase-cation symporter-2 (NAT/NCS2) family is one of the five known families of transporters that use nucleobases as their principal substrates and the only one that is evolutionarily conserved and widespread in all major taxa of organisms.	nucleobases	147-158	bromodomain containing 2	Homo sapiens	71-74
23097742-1	2012	The nucleobase-ascorbate transporter or nucleobase-cation symporter-2 (NAT/NCS2) family is one of the five known families of transporters that use nucleobases as their principal substrates and the only one that is evolutionarily conserved and widespread in all major taxa of organisms.	nucleobases	147-158	cytosolic thiouridylase subunit 2	Homo sapiens	75-79
21245037-2	2011	We also report here the synthesis, structure and STM current-imaging studies of DNA oligonucleotides containing the nucleobases (thymine) derivatized with 5-phenyl-telluride functionality (5-Te).	nucleobases	116-127	sulfotransferase family 1A member 3	Homo sapiens	49-52
21480791-2	2011	Formamide, a hydrolysis product of HCN, is known as the precursor of various biologically important compounds, for example, nucleobases (purines and pyrimidines).	nucleobases	124-135	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	35-38
20592246-4	2010	To clarify the substrate specificity of PMAT, we comprehensively analyzed the transport activity of human PMAT toward nucleosides, nucleobases, and organic cations in heterologous expression systems under well controlled conditions.	nucleobases	131-142	solute carrier family 29 member 4	Homo sapiens	106-110
20592246-5	2010	Among 12 naturally occurring nucleosides and nucleobases, only adenosine was significantly transported by PMAT.	nucleobases	45-56	solute carrier family 29 member 4	Homo sapiens	106-110