PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8692289-1 1996 Tritiated methylphenylpyridinium ([3H]MPP+), a substrate of the neuronal and extraneuronal noradrenaline transporter (uptake1 and uptake2, respectively) and of the organic cation transporter (OCT1), was used to characterize the amine transport system of the established human glioma cell line SK-MG-1. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 34-42 solute carrier family 22 member 1 Homo sapiens 192-196 10497908-6 1999 The uptake of [3H]MPP+ into hepatocytes, known to be mediated by rOCT1, was inhibited by verapamil and vinblastine (IC50s of 2.6 and 34.4 microM, respectively). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 15-22 solute carrier family 22 member 1 Rattus norvegicus 65-70 9721755-3 1998 We tested this hypothesis in human embryonic kidney 293 cells stably transfected with the human DAT by measuring the uptake of dopamine, tyramine, and D- and L-amphetamine as well as substrate-induced release of preloaded N-methyl-4-[3H]phenylpyridinium ([3H]MPP+). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 255-263 solute carrier family 6 member 3 Homo sapiens 96-99 9528667-3 1998 rbOCT1 mediated 3H-1-methyl-4-phenylpyridinium (3H-MPP+) transport in Xenopus laevis oocytes was saturable, sensitive to membrane potential, and inhibited by various organic cations. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 48-54 solute carrier family 22 member 1 Oryctolagus cuniculus 0-6 9187257-6 1997 In Xenopus laevis oocytes injected with the cRNA of hOCT1, the specific uptake of the organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+) was significantly enhanced (8-fold) over that in water-injected oocytes. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 133-139 solute carrier family 22 member 1 Homo sapiens 52-57 9187257-9 1997 In addition, the bile acid taurocholate inhibited the uptake of 3H-MPP+ in oocytes expressing hOCT1. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 64-71 solute carrier family 22 member 1 Homo sapiens 94-99 8692289-5 1996 IC50 (or Ki) values for inhibition of [3H]MPP+ uptake by substrates and inhibitors of uptake2 or OCT1 were highly significantly correlated with published IC50 values for inhibition of uptake2 but not with corresponding values for inhibition of OCT1. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 38-46 solute carrier family 22 member 1 Homo sapiens 97-101 3264161-5 1988 Moreover, [3H]MPP+ uptake is blocked by the monoamine transporter inhibitors tetrabenazine and reserpine. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 11-18 solute carrier family 18 member A2 Homo sapiens 44-65 2338548-4 1990 We found a certain correlation between the ability of these agents to displace [3H]MPP+ from its binding sites and their capacity to inhibit MAO-A activity. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 79-87 monoamine oxidase A Mus musculus 141-146 2633172-0 1989 Correspondence between 3H-MPP+ binding site and MAO-A enzyme: pharmacological evidences. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 23-30 monoamine oxidase A Homo sapiens 48-53 3875815-3 1985 We now report that [3H]MPTP is rapidly converted in vitro into [3H]MPP+ by human platelet MAO-B. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 63-70 monoamine oxidase B Homo sapiens 90-95 19190342-6 2009 Uptake of the organic cation [(3)H]MPP (4-methyl-pyridinium iodide) into these cells and also into hOCT3 stably transfected Chinese hamster ovary (CHO) cells was inhibited by irinotecan, vincristine, and melphalan. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 30-38 solute carrier family 22 member 3 Homo sapiens 99-104 32846898-4 2020 The role of FXR in OCT2 and MATEs functions was investigated by monitoring the flux of 3H-MPP+, a substrate of OCT2 and MATEs. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 87-94 POU class 2 homeobox 2 Homo sapiens 111-115 32846898-5 2020 FXR agonists chenodeoxycholic acid (CDCA) and GW4064 stimulated OCT2-mediated 3H-MPP+ uptake in human renal proximal tubular cells (RPTEC/TERT1 cells) and OCT2-CHO-K1 cells. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 78-85 nuclear receptor subfamily 1 group H member 4 Homo sapiens 0-3 32846898-5 2020 FXR agonists chenodeoxycholic acid (CDCA) and GW4064 stimulated OCT2-mediated 3H-MPP+ uptake in human renal proximal tubular cells (RPTEC/TERT1 cells) and OCT2-CHO-K1 cells. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 78-85 POU class 2 homeobox 2 Homo sapiens 64-68 28741179-3 2017 Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 119-126 nuclear receptor subfamily 1, group H, member 3 Mus musculus 10-13 28741179-3 2017 Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 119-126 nuclear receptor subfamily 1, group H, member 3 Mus musculus 46-49 28741179-3 2017 Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 119-126 solute carrier family 22 member 2 Homo sapiens 154-158 28741179-3 2017 Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1). 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 119-126 solute carrier family 22 member 2 Homo sapiens 168-172 3875815-4 1985 The formation of [3H]MPP+ in human platelets is prevented by specific MAO-B but not by MAO-A or by 5-hydroxytryptamine uptake inhibitors. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 17-25 monoamine oxidase B Homo sapiens 70-75 33132314-5 2020 Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 91-98 solute carrier family 22 member 2 Homo sapiens 42-46 23458604-5 2013 In OCT-expressing oocytes, [(3)H]MPP(+) uptake rates were 15- to 35-fold higher than in noninjected oocytes, whereas those for [(3)H]spermidine increased more modestly above the background, up to 3-fold. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 27-39 plexin A2 Homo sapiens 3-6 11770002-4 2001 The characteristics of hEMT-mediated uptake of [3H]1-methyl-4-phenylpyridinium ([3H]MPP+) were studied by incubating the cells at 37 degrees C for 1 min with 200 nM [3H]MPP+. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 80-87 IL2 inducible T cell kinase Homo sapiens 23-27 17225960-0 2007 Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 88-95 somatostatin Bos taurus 23-35 12176030-3 2002 The uptakes of [(3)H]MPP(+) via mOCT1 and mOCT2 were saturable, with similar Michaelis constants (K(t)) of 10 and 24 microM, respectively. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 15-24 solute carrier family 22 (organic cation transporter), member 1 Mus musculus 32-37 12176030-3 2002 The uptakes of [(3)H]MPP(+) via mOCT1 and mOCT2 were saturable, with similar Michaelis constants (K(t)) of 10 and 24 microM, respectively. 3-hydroxy-1-methyl-3-phenyl-2-piperidinone 15-24 solute carrier family 22 (organic cation transporter), member 2 Mus musculus 42-47