PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19190342-6	2009	Uptake of the organic cation [(3)H]MPP (4-methyl-pyridinium iodide) into these cells and also into hOCT3 stably transfected Chinese hamster ovary (CHO) cells was inhibited by irinotecan, vincristine, and melphalan.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	30-38	solute carrier family 22 member 3	Homo sapiens	99-104
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	119-126	nuclear receptor subfamily 1, group H, member 3	Mus musculus	10-13
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	119-126	nuclear receptor subfamily 1, group H, member 3	Mus musculus	46-49
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	119-126	solute carrier family 22 member 2	Homo sapiens	154-158
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	119-126	solute carrier family 22 member 2	Homo sapiens	168-172
23458604-5	2013	In OCT-expressing oocytes, [(3)H]MPP(+) uptake rates were 15- to 35-fold higher than in noninjected oocytes, whereas those for [(3)H]spermidine increased more modestly above the background, up to 3-fold.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	27-39	plexin A2	Homo sapiens	3-6
11770002-4	2001	The characteristics of hEMT-mediated uptake of [3H]1-methyl-4-phenylpyridinium ([3H]MPP+) were studied by incubating the cells at 37 degrees C for 1 min with 200 nM [3H]MPP+.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	80-87	IL2 inducible T cell kinase	Homo sapiens	23-27
17225960-0	2007	Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	88-95	somatostatin	Bos taurus	23-35
12176030-3	2002	The uptakes of [(3)H]MPP(+) via mOCT1 and mOCT2 were saturable, with similar Michaelis constants (K(t)) of 10 and 24 microM, respectively.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	15-24	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	32-37
12176030-3	2002	The uptakes of [(3)H]MPP(+) via mOCT1 and mOCT2 were saturable, with similar Michaelis constants (K(t)) of 10 and 24 microM, respectively.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	15-24	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	42-47
10497908-6	1999	The uptake of [3H]MPP+ into hepatocytes, known to be mediated by rOCT1, was inhibited by verapamil and vinblastine (IC50s of 2.6 and 34.4 microM, respectively).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	15-22	solute carrier family 22 member 1	Rattus norvegicus	65-70
9528667-3	1998	rbOCT1 mediated 3H-1-methyl-4-phenylpyridinium (3H-MPP+) transport in Xenopus laevis oocytes was saturable, sensitive to membrane potential, and inhibited by various organic cations.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	48-54	solute carrier family 22 member 1	Oryctolagus cuniculus	0-6
9721755-3	1998	We tested this hypothesis in human embryonic kidney 293 cells stably transfected with the human DAT by measuring the uptake of dopamine, tyramine, and D- and L-amphetamine as well as substrate-induced release of preloaded N-methyl-4-[3H]phenylpyridinium ([3H]MPP+).	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	255-263	solute carrier family 6 member 3	Homo sapiens	96-99
2338548-4	1990	We found a certain correlation between the ability of these agents to displace [3H]MPP+ from its binding sites and their capacity to inhibit MAO-A activity.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	79-87	monoamine oxidase A	Mus musculus	141-146
9187257-6	1997	In Xenopus laevis oocytes injected with the cRNA of hOCT1, the specific uptake of the organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+) was significantly enhanced (8-fold) over that in water-injected oocytes.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	133-139	solute carrier family 22 member 1	Homo sapiens	52-57
9187257-9	1997	In addition, the bile acid taurocholate inhibited the uptake of 3H-MPP+ in oocytes expressing hOCT1.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	64-71	solute carrier family 22 member 1	Homo sapiens	94-99
8692289-1	1996	Tritiated methylphenylpyridinium ([3H]MPP+), a substrate of the neuronal and extraneuronal noradrenaline transporter (uptake1 and uptake2, respectively) and of the organic cation transporter (OCT1), was used to characterize the amine transport system of the established human glioma cell line SK-MG-1.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	34-42	solute carrier family 22 member 1	Homo sapiens	192-196
8692289-5	1996	IC50 (or Ki) values for inhibition of [3H]MPP+ uptake by substrates and inhibitors of uptake2 or OCT1 were highly significantly correlated with published IC50 values for inhibition of uptake2 but not with corresponding values for inhibition of OCT1.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	38-46	solute carrier family 22 member 1	Homo sapiens	97-101
2633172-0	1989	Correspondence between 3H-MPP+ binding site and MAO-A enzyme: pharmacological evidences.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	23-30	monoamine oxidase A	Homo sapiens	48-53
3875815-4	1985	The formation of [3H]MPP+ in human platelets is prevented by specific MAO-B but not by MAO-A or by 5-hydroxytryptamine uptake inhibitors.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	17-25	monoamine oxidase B	Homo sapiens	70-75
3264161-5	1988	Moreover, [3H]MPP+ uptake is blocked by the monoamine transporter inhibitors tetrabenazine and reserpine.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	11-18	solute carrier family 18 member A2	Homo sapiens	44-65
3875815-3	1985	We now report that [3H]MPTP is rapidly converted in vitro into [3H]MPP+ by human platelet MAO-B.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	63-70	monoamine oxidase B	Homo sapiens	90-95
33132314-5	2020	Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	91-98	solute carrier family 22 member 2	Homo sapiens	42-46
32846898-4	2020	The role of FXR in OCT2 and MATEs functions was investigated by monitoring the flux of 3H-MPP+, a substrate of OCT2 and MATEs.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	87-94	POU class 2 homeobox 2	Homo sapiens	111-115
32846898-5	2020	FXR agonists chenodeoxycholic acid (CDCA) and GW4064 stimulated OCT2-mediated 3H-MPP+ uptake in human renal proximal tubular cells (RPTEC/TERT1 cells) and OCT2-CHO-K1 cells.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	78-85	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-3
32846898-5	2020	FXR agonists chenodeoxycholic acid (CDCA) and GW4064 stimulated OCT2-mediated 3H-MPP+ uptake in human renal proximal tubular cells (RPTEC/TERT1 cells) and OCT2-CHO-K1 cells.	3-hydroxy-1-methyl-3-phenyl-2-piperidinone	78-85	POU class 2 homeobox 2	Homo sapiens	64-68