PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9920389-3	1998	The specific binding of the (Hg-Se) complex but not Hg2+ or selenide to Sel P was explained by the unique binding sites consisting of the cationic and anionic ends such as imidazolyl and selenol groups on Sel P, respectively.	imidazolyl	172-182	selenoprotein P	Homo sapiens	72-77
9920389-3	1998	The specific binding of the (Hg-Se) complex but not Hg2+ or selenide to Sel P was explained by the unique binding sites consisting of the cationic and anionic ends such as imidazolyl and selenol groups on Sel P, respectively.	imidazolyl	172-182	selenoprotein P	Homo sapiens	205-210
9722671-7	1998	Upon suicide inactivation with a [15N2]imidazolyl analog, the octet signals due to Co(II) showed superhyperfine splitting into doublets, indicating axial coordination of 5,6-dimethylbenzimidazole to the cobalamin bound to diol dehydratase.	imidazolyl	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
30035285-0	2018	A zeolite-like MOF based on a heterotritopic linker of imidazolyl, carboxyl and pyridine with a long-sought uks net on Schwarz"s D-surface.	imidazolyl	55-65	lysine acetyltransferase 8	Homo sapiens	15-18
2995119-0	1985	Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors.	imidazolyl	0-10	angiotensin I converting enzyme	Homo sapiens	49-78
33278783-2	2021	In this study, three series of novel potent RyR1 inhibitors based on dantrolene and bearing semicarbazone and imidazolyl moieties were designed and synthesized, and their biological activity was evaluated.	imidazolyl	110-120	ryanodine receptor 1, skeletal muscle	Mus musculus	44-48
31037782-4	2019	For ReI compounds, addition to pyridine is found with R"=tBu and OMe, whereas for R=Me and R"=NMe2 , imidazolyl formation is preferred.	imidazolyl	101-111	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	94-98
15686906-0	2005	Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).	imidazolyl	85-95	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	126-166
29783634-4	2018	Molecular modeling studies confirmed a consolidated binding mode in which the nitrogen of the imidazolyl moiety coordinated the heme ferrous iron, meanwhile the hydrophobic groups were located in the western region of HO-1 binding pocket.	imidazolyl	94-104	heme oxygenase 1	Homo sapiens	218-222
28425134-3	2017	Copper complexes with bis(pyrazolyl)methanes with pyridinyl or imidazolyl moieties are already reported as excellent tyrosinase models.	imidazolyl	63-73	tyrosinase	Homo sapiens	117-127
23914925-5	2014	Our results were compatible with experimental published data, showing feasible cation-pi interaction between the iron atom of the heme group of TXAS and the basic nitrogen atom of the imidazolyl group of those inhibitors.	imidazolyl	184-194	thromboxane A synthase 1	Homo sapiens	144-148
21341743-0	2011	Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase.	imidazolyl	48-58	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	105-114
25541201-3	2015	Based on selective activity of hMAO-A, SAR analysis showed that the order of N1 substituent contribution was bromo (3)>piperidinyl (4)>morpholinyl (5)>imidazolyl (6), and compounds with electron-withdrawing substituents (-F, -Cl) at C3 or C5 phenyl ring of 2-pyrazoline nucleus dedicated stronger MAO-A inhibitory activity.	imidazolyl	160-170	monoamine oxidase A	Homo sapiens	31-37
25541201-3	2015	Based on selective activity of hMAO-A, SAR analysis showed that the order of N1 substituent contribution was bromo (3)>piperidinyl (4)>morpholinyl (5)>imidazolyl (6), and compounds with electron-withdrawing substituents (-F, -Cl) at C3 or C5 phenyl ring of 2-pyrazoline nucleus dedicated stronger MAO-A inhibitory activity.	imidazolyl	160-170	monoamine oxidase A	Homo sapiens	32-37
22366075-3	2012	The imidazolyl substituted steroidal derivatives 6 (DPJ-RG-1241) and 7 (RB-401) were obtained as the powerful inhibitors of aromatase with IC50=0.18 muM and IC50=0.168 muM, respectively, approximately 1.2 and 1.4 times more potent in comparison to standard drug exemestane.	imidazolyl	4-14	latexin	Homo sapiens	149-152
22366075-3	2012	The imidazolyl substituted steroidal derivatives 6 (DPJ-RG-1241) and 7 (RB-401) were obtained as the powerful inhibitors of aromatase with IC50=0.18 muM and IC50=0.168 muM, respectively, approximately 1.2 and 1.4 times more potent in comparison to standard drug exemestane.	imidazolyl	4-14	latexin	Homo sapiens	168-171
20684610-0	2010	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.	imidazolyl	15-25	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	80-85
20684610-0	2010	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.	imidazolyl	15-25	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	95-100
20684610-0	2010	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.	imidazolyl	15-25	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	101-108
15686906-0	2005	Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).	imidazolyl	85-95	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	168-172
15203142-1	2004	The synthesized imidazolyl substituted delta2-isoxazolines were subjected to Phospholipase A(2) (PLA(2)) enzyme inhibitory activity against snake venom source and their structure-activity relationship with respect to different groups attached to this moiety is reported for the first time.	imidazolyl	16-26	phospholipase A2, group IB, pancreas	Mus musculus	77-95
15203142-1	2004	The synthesized imidazolyl substituted delta2-isoxazolines were subjected to Phospholipase A(2) (PLA(2)) enzyme inhibitory activity against snake venom source and their structure-activity relationship with respect to different groups attached to this moiety is reported for the first time.	imidazolyl	16-26	phospholipase A2, group IB, pancreas	Mus musculus	97-103