PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29862811-1	2018	The bacterial enzyme tRNA-guanine transglycosylase (TGT) is involved in the biosynthesis of queuosine, a modified nucleoside present in the anticodon wobble position of tRNAHis, tRNATyr, tRNAAsp, and tRNAAsn.	Nucleoside Q	92-101	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	21-50
29862811-1	2018	The bacterial enzyme tRNA-guanine transglycosylase (TGT) is involved in the biosynthesis of queuosine, a modified nucleoside present in the anticodon wobble position of tRNAHis, tRNATyr, tRNAAsp, and tRNAAsn.	Nucleoside Q	92-101	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	52-55
1378304-1	1992	Queuosine (Q), found exclusively in the first position of the anticodons of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr), is synthesized in eucaryotes by a base-for-base exchange of queuine, the base of Q, for guanine at tRNA position 34.	Nucleoside Q	0-9	mitochondrially encoded tRNA glycine	Homo sapiens	87-96
21487017-8	2011	Here, we show that human HepG2 cells deficient in queuine and mice made deficient in queuosine-modified transfer RNA, by disruption of the tRNA guanine transglycosylase enzyme, are compromised in their ability to produce tyrosine from phenylalanine.	Nucleoside Q	85-94	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	139-168
16164993-7	2005	Among Escherichia coli tRNAs containing queuosine in the wobble position, only tRNA(Asp) is substrate of YadB.	Nucleoside Q	40-49	hypothetical protein	Escherichia coli	105-109
1511436-11	1992	These results, taken together with other previous studies, suggest that a decreased queuosine content of tRNA may be a general feature of neoplasms and may be useful for grading malignancy and perhaps also for the prediction of survival in human lung cancer.	Nucleoside Q	84-93	mitochondrially encoded tRNA glycine	Homo sapiens	105-109
21999246-6	2012	Notably, this work identified and experimentally validated dual function PTPS-I/III enzymes involved in both THF and Q biosynthesis.	Nucleoside Q	117-118	6-pyruvoyltetrahydropterin synthase	Homo sapiens	73-77
21131277-1	2011	The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea.	Nucleoside Q	66-75	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	11-40
21131277-1	2011	The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea.	Nucleoside Q	66-75	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	42-45
20333371-4	2010	One nearly universal modification is queuosine (Q) for guanine (G) in tRNA(His), tRNA(Asp), tRNA(Asn), and tRNA(Tyr); this changes the optimal binding from codons ending in C to no preference or a slight preference for U-ending codons.	Nucleoside Q	37-46	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	81-90
15246567-1	2004	tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA.	Nucleoside Q	90-99	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	0-29
15246567-1	2004	tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA.	Nucleoside Q	90-99	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	31-34
15150343-2	2004	We show that YadB is a tRNA modifying enzyme that evidently glutamylates the queuosine residue, a modified nucleoside at the wobble position of the tRNA(Asp) QUC anticodon.	Nucleoside Q	77-86	hypothetical protein	Escherichia coli	13-17
11255023-1	2001	Queuosine (Q) is a 7-deazaguanosine found in the first position of the anticodon of tRNAs that recognize NAU and NAC codons (Tyr, Asn, Asp and His).	Nucleoside Q	0-9	X-linked Kx blood group	Homo sapiens	113-116
11134952-1	2001	Queuosine is a modified nucleoside located at the first position of the tRNA anticodon, which is synthesized by tRNA-guanine transglycosylase (TGT).	Nucleoside Q	0-9	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	112-141
11134952-1	2001	Queuosine is a modified nucleoside located at the first position of the tRNA anticodon, which is synthesized by tRNA-guanine transglycosylase (TGT).	Nucleoside Q	0-9	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	143-146
11134952-4	2001	Contrary of our expectations, the results revealed higher levels of expression of TGT60KD than that in normal cells, and the level of queuosine in the tRNA fraction corresponded with that of TGT60KD expression.	Nucleoside Q	134-143	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	191-198
11134952-5	2001	These results suggest the possibilities that the expression levels of TGT60KD regulate TGT activity and the levels of queuosine, and that TGT60KD plays significant roles in carcinogenesis.	Nucleoside Q	118-127	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	70-77
11134952-5	2001	These results suggest the possibilities that the expression levels of TGT60KD regulate TGT activity and the levels of queuosine, and that TGT60KD plays significant roles in carcinogenesis.	Nucleoside Q	118-127	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	70-73
11134952-5	2001	These results suggest the possibilities that the expression levels of TGT60KD regulate TGT activity and the levels of queuosine, and that TGT60KD plays significant roles in carcinogenesis.	Nucleoside Q	118-127	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	138-145
7630726-1	1995	The eukaryotic tRNA:guanine transglycosylase (TGT) catalyses the base-for-base exchange of guanine for queuine (the q-base)--a nutrition factor for eukaryotes--at position 34 of the anticodon of tRNAsGUN (where "N" represents one of the four canonical tRNA nucleosides), yielding the modified tRNA nucleoside queuosine (Q).	Nucleoside Q	309-318	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	15-44
7630726-1	1995	The eukaryotic tRNA:guanine transglycosylase (TGT) catalyses the base-for-base exchange of guanine for queuine (the q-base)--a nutrition factor for eukaryotes--at position 34 of the anticodon of tRNAsGUN (where "N" represents one of the four canonical tRNA nucleosides), yielding the modified tRNA nucleoside queuosine (Q).	Nucleoside Q	309-318	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	46-49
7889496-1	1994	Queuosine (Q nucleoside) is a highly modified guanosine analog and is present only in the first position of the anticodons of tRNA(Tyr), tRNA(His), tRNA(Asn) and tRNA(Asp).	Nucleoside Q	0-9	mitochondrially encoded tRNA glycine	Homo sapiens	148-157
7889496-1	1994	Queuosine (Q nucleoside) is a highly modified guanosine analog and is present only in the first position of the anticodons of tRNA(Tyr), tRNA(His), tRNA(Asn) and tRNA(Asp).	Nucleoside Q	11-23	mitochondrially encoded tRNA glycine	Homo sapiens	148-157
32439717-0	2020	Detection and quantification of glycosylated queuosine modified tRNAs by acid denaturing and APB gels.	Nucleoside Q	45-54	arginyl aminopeptidase	Homo sapiens	93-96
3927305-2	1985	In addition, because of the 7-substituent, Q nucleoside also is hypothesized to bind as the syn conformer and, therefore, to be a potential B-lymphocyte activator.	Nucleoside Q	43-55	synemin	Homo sapiens	92-95
6561966-1	1984	Queuine (the base of queuosine, Q) catalytically reduced with tritium or deuterium yields a derivative in which the proton at C-8 (purine numbering system) has been exchanged and the cyclopentene ring has been reduced to a cyclopentane ring.	Nucleoside Q	0-7	homeobox C8	Homo sapiens	126-129
6561966-1	1984	Queuine (the base of queuosine, Q) catalytically reduced with tritium or deuterium yields a derivative in which the proton at C-8 (purine numbering system) has been exchanged and the cyclopentene ring has been reduced to a cyclopentane ring.	Nucleoside Q	21-30	homeobox C8	Homo sapiens	126-129
6844700-9	1983	The enzyme tRNA-guanine transglycosylase, which is a key enzyme in biosynthesis of queuosine in tRNA (inserting Q base into tRNA by a transglycosylase reaction), is active in both tumor cells and normal cells.	Nucleoside Q	83-92	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	11-40
6808062-0	1982	[tRNA guanine transglycosylase and biosynthesis of Q nucleoside present in tRNA as a minor component (author"s transl)].	Nucleoside Q	51-63	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	1-30
6986171-7	1980	Thus, the actual substrate for tRNA-guanine transglycosylase in queuosine biosynthesis in vivo in rat liver may not be 7-(aminomethyl)-7-deazaguanine, which is thought to be an actual substrate guanine, the E. coli system.	Nucleoside Q	64-73	queuine tRNA-ribosyltransferase catalytic subunit 1	Rattus norvegicus	31-60
6986171-8	1980	Queuine or some queuine derivative may be the actual substrate for the tRNA-guanine transglycosylase reaction in the biosynthesis of Q in tRNA of mammalian cells.	Nucleoside Q	0-1	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	71-100
35061353-4	2022	While the initial step in the catalytic cycle of QueG likely involves the formation of a reduced Co(I)Cbl species, the mechanisms employed by this enzyme to accomplish the thermodynamically challenging reduction of base-off Co(II)Cbl to Co(I)Cbl and to convert oQ to Q remain unknown.	Nucleoside Q	267-268	Cbl proto-oncogene	Homo sapiens	102-105