PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11389684-4	2001	Daily treatment of confluent cells with 0.75 mM tyramine (a substrate of MAO and SSAO) or benzylamine (a substrate of SSAO) over 1 week caused the acquisition of typical adipocyte morphology.	Tyramine	48-56	monoamine oxidase A	Rattus norvegicus	73-76
11776438-4	2001	A series of novel N-substituted tyramine (2-p-hydroxyphenylethylamine) derivatives (1 to approximately 11) were synthesized and evaluated for their inhibitory activity against pig kidney aldose reductase (EC 1, 1, 1, 21).	Tyramine	42-69	aldo-keto reductase family 1 member B	Sus scrofa	187-203
11430910-6	2001	The endogenous organic cation tyramine, but not choline, inhibited EMT-mediated transport (IC(50) of 468 microM).	Tyramine	30-38	solute carrier family 22 member 3	Homo sapiens	67-70
11389684-4	2001	Daily treatment of confluent cells with 0.75 mM tyramine (a substrate of MAO and SSAO) or benzylamine (a substrate of SSAO) over 1 week caused the acquisition of typical adipocyte morphology.	Tyramine	48-56	amine oxidase, copper containing 3	Mus musculus	81-85
11336106-4	2001	tyramine was potentiated by the MAO-A inhibitors clorgyline (0.1-1.0 mg/kg i.v.)	Tyramine	0-8	monoamine oxidase A	Rattus norvegicus	32-37
11156574-6	2001	Nevertheless, L-DOPA and two other substrates, namely, catechol and tyramine did produce nitric oxide from Angeli"s salt in the presence of tyrosinase, suggesting involvement of the respective unstable quinones.	Tyramine	68-76	tyrosinase	Rattus norvegicus	140-150
11226418-5	2001	Moreover we could show that addition of substrate tyramine to H2O2 incubates is responsible for a partial protection of DbH against inactivation.	Tyramine	50-58	dopamine beta-hydroxylase	Bos taurus	120-123
11259630-1	2001	The human monoamine oxidase (MAO) B plays a major role in the degradation of biogenic and dietary amines such as phenylethylamine, benzylamine, dopamine, and tyramine.	Tyramine	158-166	monoamine oxidase B	Homo sapiens	10-35
10713442-10	2000	These results indicate that tyramine has a functional role in the Drosophila olfactory system as a neurotransmitter or a neuromodulator, and hono is the first tyramine receptor mutant.	Tyramine	28-36	Tyramine receptor	Drosophila melanogaster	159-176
11125028-6	2001	The substrate selectivity of dDAT parallels that of the mammalian DATs in that dopamine and tyramine are the preferred substrates, whereas octopamine is transported less efficiently, and serotonin not at all.	Tyramine	92-100	Dopamine transporter	Drosophila melanogaster	29-33
10777699-3	2000	The MAO substrate tyramine induced tyrosine phosphorylation of Shc, ERK activation, and an increase in DNA synthesis in HEK 293 expressing MAO-B, but not in wild type HEK 293 cells, which do not express MAO.	Tyramine	18-26	SHC adaptor protein 1	Homo sapiens	63-66
10777699-3	2000	The MAO substrate tyramine induced tyrosine phosphorylation of Shc, ERK activation, and an increase in DNA synthesis in HEK 293 expressing MAO-B, but not in wild type HEK 293 cells, which do not express MAO.	Tyramine	18-26	mitogen-activated protein kinase 1	Homo sapiens	68-71
10777699-3	2000	The MAO substrate tyramine induced tyrosine phosphorylation of Shc, ERK activation, and an increase in DNA synthesis in HEK 293 expressing MAO-B, but not in wild type HEK 293 cells, which do not express MAO.	Tyramine	18-26	monoamine oxidase B	Homo sapiens	139-144
10737611-0	2000	Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter.	Tyramine	81-89	solute carrier family 6 member 3	Homo sapiens	103-123
10926841-1	2000	It has been shown that the combination of benzylamine or tyramine and low concentrations of vanadate markedly stimulates glucose transport in rat adipocytes by a mechanism that requires semicarbazide-sensitive amine oxidase (SSAO) activity and H(2)O(2) formation.	Tyramine	57-65	amine oxidase, copper containing 3	Rattus norvegicus	186-223
10926841-1	2000	It has been shown that the combination of benzylamine or tyramine and low concentrations of vanadate markedly stimulates glucose transport in rat adipocytes by a mechanism that requires semicarbazide-sensitive amine oxidase (SSAO) activity and H(2)O(2) formation.	Tyramine	57-65	amine oxidase, copper containing 3	Rattus norvegicus	225-229
10926841-3	2000	We found that several SSAO substrates (benzylamine, tyramine, methylamine, n-decylamine, histamine, tryptamine or beta-phenylethylamine), in combination with low concentrations of vanadate, stimulate glucose transport in isolated rat adipocytes.	Tyramine	52-60	amine oxidase, copper containing 3	Rattus norvegicus	22-26
10926841-6	2000	Benzylamine or tyramine in combination with vanadate potently stimulated the tyrosine phosphorylation of both insulin receptor substrate (IRS)-1 and IRS-3.	Tyramine	15-23	insulin receptor substrate 1	Rattus norvegicus	110-144
10926841-6	2000	Benzylamine or tyramine in combination with vanadate potently stimulated the tyrosine phosphorylation of both insulin receptor substrate (IRS)-1 and IRS-3.	Tyramine	15-23	insulin receptor substrate 3	Rattus norvegicus	149-154
11008881-1	2000	Monoamine oxidase (MAO) and benzylamine oxidases (Bz-SSAO) of rat white adipocytes, deaminating benzylamine and tyramine produce hydrogen peroxide at different cellular levels.	Tyramine	112-120	amine oxidase, copper containing 3	Rattus norvegicus	53-57
10640514-10	2000	Thus, for polymorphic forms of human FMO3, lower k(cat)/K(m) values for N-oxygenation of 10-(N, N-dimethylaminopentyl)-2-(trifluoromethyl) phenothiazine, trimethylamine, and tyramine were observed.	Tyramine	174-182	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	37-41
10582588-4	1999	In these experiments, incubation of rat brain mitochondria with tyramine (a mixed MAO-A/MAO-B substrate) for 15 min at 27 degrees C suppressed state 3 respiration by 32.8% and state 5 respiration by 40.1%.	Tyramine	64-72	monoamine oxidase A	Rattus norvegicus	82-87
10571247-4	1999	Characterization of the enzyme isoforms by inhibition profiles of [14C]tyramine oxidation and Western and Northern blot analyses showed that mRNAs and proteins related to both monoamine oxidases A and B were expressed in adipocytes.	Tyramine	71-79	monoamine oxidase A	Homo sapiens	176-202
10647887-7	1999	The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine.	Tyramine	191-199	monoamine oxidase A	Homo sapiens	128-133
10582588-4	1999	In these experiments, incubation of rat brain mitochondria with tyramine (a mixed MAO-A/MAO-B substrate) for 15 min at 27 degrees C suppressed state 3 respiration by 32.8% and state 5 respiration by 40.1%.	Tyramine	64-72	monoamine oxidase B	Rattus norvegicus	88-93
10422637-0	1999	Tyramine produces interstitial adenosine-mediated activation of ecto-5"-nucleotidase in rat heart in vivo.	Tyramine	0-8	5' nucleotidase, ecto	Rattus norvegicus	64-84
10441143-8	1999	When comparing the specificity of SULT1A3 toward tyramine with that for p-ethylphenol (which differs from tyramine in having no amine group on the carbon side chain), we saw a 200-fold preference for tyramine.	Tyramine	49-57	sulfotransferase family 1A member 3	Homo sapiens	34-41
10441143-8	1999	When comparing the specificity of SULT1A3 toward tyramine with that for p-ethylphenol (which differs from tyramine in having no amine group on the carbon side chain), we saw a 200-fold preference for tyramine.	Tyramine	106-114	sulfotransferase family 1A member 3	Homo sapiens	34-41
10441143-8	1999	When comparing the specificity of SULT1A3 toward tyramine with that for p-ethylphenol (which differs from tyramine in having no amine group on the carbon side chain), we saw a 200-fold preference for tyramine.	Tyramine	106-114	sulfotransferase family 1A member 3	Homo sapiens	34-41
10469593-5	1999	Mutant flies had reduced amounts of the trace amine tyramine in the brain because of reduced activity of the enzyme tyrosine decarboxylase (TDC), which converts tyrosine to tyramine.	Tyramine	52-60	Tyrosine decarboxylase 1	Drosophila melanogaster	116-138
10469593-5	1999	Mutant flies had reduced amounts of the trace amine tyramine in the brain because of reduced activity of the enzyme tyrosine decarboxylase (TDC), which converts tyrosine to tyramine.	Tyramine	52-60	Tyrosine decarboxylase 1	Drosophila melanogaster	140-143
10469593-5	1999	Mutant flies had reduced amounts of the trace amine tyramine in the brain because of reduced activity of the enzyme tyrosine decarboxylase (TDC), which converts tyrosine to tyramine.	Tyramine	173-181	Tyrosine decarboxylase 1	Drosophila melanogaster	116-138
10469593-5	1999	Mutant flies had reduced amounts of the trace amine tyramine in the brain because of reduced activity of the enzyme tyrosine decarboxylase (TDC), which converts tyrosine to tyramine.	Tyramine	173-181	Tyrosine decarboxylase 1	Drosophila melanogaster	140-143
10422637-8	1999	Tyramine (1 mM) increased the adenosine concentration measured in the presence of 100 microM AMP (i.e., the activity of ecto-5"-nucleotidase) by 65.8 +/- 19.9% (n = 6, P < 0.05), an increase which was inhibited by an antagonist of the alpha1-adrenoceptor (prazosin, 50 microM) or of protein kinase C (chelerythrine, 10 microM).	Tyramine	0-8	5' nucleotidase, ecto	Rattus norvegicus	120-140
10422637-13	1999	The results suggest that tyramine elevates adenosine via stimulation of alpha1-adrenoceptors and protein kinase C-mediated activation of ecto-5"-nucleotidase in rat heart.	Tyramine	25-33	5' nucleotidase, ecto	Rattus norvegicus	137-157
10082842-4	1999	However, Glu into the ACe in the presence of NE or tyramine elicited depressor or bradycardic response that were significantly smaller (70-100%) in magnitude than to Glu alone.	Tyramine	51-59	angiotensin I converting enzyme	Rattus norvegicus	22-25
10498294-5	1999	Our results showed that cell incubation with tyramine (50 micromol/l) led to a time-dependent H2O2 generation which was fully inhibited by MAO A (clorgyline and RO 41-1049) and MAO B (selegiline and RO 19-6327) inhibitors.	Tyramine	45-53	monoamine oxidase A	Homo sapiens	139-144
10498294-5	1999	Our results showed that cell incubation with tyramine (50 micromol/l) led to a time-dependent H2O2 generation which was fully inhibited by MAO A (clorgyline and RO 41-1049) and MAO B (selegiline and RO 19-6327) inhibitors.	Tyramine	45-53	monoamine oxidase B	Homo sapiens	177-182
10333983-14	1998	These results suggest that befloxatone is a potent reversible MAO-A inhibitor with antidepressant potential and a wide safety margin with regard to the potentiation of the pressor effect of tyramine.	Tyramine	190-198	monoamine oxidase A	Rattus norvegicus	62-67
9721755-0	1998	Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter.	Tyramine	87-95	solute carrier family 6 member 3	Homo sapiens	156-176
9731223-0	1998	Dopamine formation from tyramine by CYP2D6.	Tyramine	24-32	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	36-42
9721755-3	1998	We tested this hypothesis in human embryonic kidney 293 cells stably transfected with the human DAT by measuring the uptake of dopamine, tyramine, and D- and L-amphetamine as well as substrate-induced release of preloaded N-methyl-4-[3H]phenylpyridinium ([3H]MPP+).	Tyramine	137-145	solute carrier family 6 member 3	Homo sapiens	96-99
9731223-4	1998	Among the 11 isoforms of human CYP expressed in yeast, CYP2D6 was the only isoform exhibiting strong ability to convert p-tyramine and m-tyramine to dopamine.	Tyramine	120-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-34
9731223-4	1998	Among the 11 isoforms of human CYP expressed in yeast, CYP2D6 was the only isoform exhibiting strong ability to convert p-tyramine and m-tyramine to dopamine.	Tyramine	120-130	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	55-61
9731223-5	1998	In studies with human hepatic microsomes, the hydroxylation of tyramine to dopamine was inhibited by bufuralol, a typical substrate for CYP2D isoforms, and anti-CYP2D1 antiserum.	Tyramine	63-71	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	136-141
9731223-6	1998	This is the first report showing that CYP2D is capable of converting tyramine to dopamine.	Tyramine	69-77	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	38-43
9731223-7	1998	The Km values of CYP2D6, expressed in yeast, for p-tyramine and m-tyramine were 190.1 +/- 19.5 microM and 58.2 +/- 13.8 microM, respectively.	Tyramine	49-59	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	17-23
9731223-9	1998	Our results suggest that dopamine is formed from endogenous and/or exogenous tyramine by this CYP2D isoform.	Tyramine	77-85	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	94-99
9675034-5	1998	17beta-Estradiol treatment for 2 weeks significantly increased (P < 0.01) MAO activity in the hamster kidney (76.7 +/- 10.0 and 113.0 +/- 10.8% over controls for the substrates tyramine and kynuramine, respectively).	Tyramine	180-188	monoamine oxidase A	Rattus norvegicus	77-80
9794720-9	1998	Administration of tyramine induced only a plateau vasoconstrictor phase; the FBFi: FBFc ratio decreased by 49+/-6% before and 63+/-5% during infusion of insulin (P < 0.01).	Tyramine	18-26	insulin	Homo sapiens	153-160
9794720-12	1998	Infusion of insulin significantly reduced the apparent concentrations of norepinephrine and tyramine at which half maximal effect occurs (EC50).	Tyramine	92-100	insulin	Homo sapiens	12-19
9622553-3	1998	It is believed that a monoamine oxidase (MAO) inhibitor specific for MAO A, which is reversibly bound to this enzyme and displaceable by tyramine, will be an antidepressant which will not cause a rise in blood pressure when tyramine-containing foods are ingested.	Tyramine	137-145	monoamine oxidase A	Homo sapiens	69-74
9622553-3	1998	It is believed that a monoamine oxidase (MAO) inhibitor specific for MAO A, which is reversibly bound to this enzyme and displaceable by tyramine, will be an antidepressant which will not cause a rise in blood pressure when tyramine-containing foods are ingested.	Tyramine	224-232	monoamine oxidase A	Homo sapiens	69-74
9512925-4	1997	The CYP1A2 dependent O-demethylation of methoxyresorufin in 3-methylcholanthrene induced hepatocytes was also markedly enhanced when intracellular H2O2 was generated by the mitochondrial monoamine oxidase (MAO) substrates tyramine or kynurenamine.	Tyramine	222-230	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
9572675-3	1998	Platelet MAO-B activity was measured using [14C]tyramine as substrate.	Tyramine	48-56	monoamine oxidase B	Homo sapiens	9-14
9413928-1	1998	The relationship between monoamine oxidase (EC 1.4.3.4; MAO) and peroxidase (EC 1.11.1.7; POD) in the metabolism of tyramine was investigated using the crude mitochondrial fraction of rat intestine.	Tyramine	116-124	monoamine oxidase A	Rattus norvegicus	56-59
9413928-4	1998	A similar value was found for the oxidative deamination of tyramine catalysed by intestinal MAO.	Tyramine	59-67	monoamine oxidase A	Rattus norvegicus	92-95
9413928-10	1998	These results indicate that the peroxidase-dependent metabolism of tyramine in the gut may be driven by H2O2 produced by MAO activities and that MAO-A is mainly responsible for this process, as well as for the oxidative deamination of tyramine.	Tyramine	67-75	monoamine oxidase A	Rattus norvegicus	121-124
9413928-10	1998	These results indicate that the peroxidase-dependent metabolism of tyramine in the gut may be driven by H2O2 produced by MAO activities and that MAO-A is mainly responsible for this process, as well as for the oxidative deamination of tyramine.	Tyramine	67-75	monoamine oxidase A	Rattus norvegicus	145-150
9413928-10	1998	These results indicate that the peroxidase-dependent metabolism of tyramine in the gut may be driven by H2O2 produced by MAO activities and that MAO-A is mainly responsible for this process, as well as for the oxidative deamination of tyramine.	Tyramine	235-243	monoamine oxidase A	Rattus norvegicus	145-150
9663810-22	1998	CONCLUSIONS: The potentiation of tyramine-evoked mydriasis by moclobemide is likely to reflect the inhibition of MAO-A activity in the iris, consistent with the activity of this enzyme in sympathetic nerve terminals.	Tyramine	33-41	monoamine oxidase A	Homo sapiens	113-118
9503566-2	1997	Although tyramine is a substrate for both MAO-A and -B, it is only inhibitors of the former enzyme, which are also the effective antidepressants, that give rise to the cheese reaction.	Tyramine	9-17	monoamine oxidase A	Homo sapiens	42-54
9503566-5	1997	The development of reversible inhibitors of monoamine oxidase-A (RIMAs) has reduced this hypertensive response since rising tyramine concentrations can displace the inhibitor from the enzyme and thus allow some metabolism to occur.	Tyramine	124-132	monoamine oxidase A	Homo sapiens	44-63
31026895-0	1997	Tyramine Formation by Pediococcus spp.	Tyramine	0-8	histocompatibility minor 13	Homo sapiens	34-37
9282832-4	1997	The conclusion that FMO was predominantly responsible for trans oxime formation in human liver microsomes was based on the effect of incubation conditions on tyramine N-oxygenation and the observation that cDNA-expressed human FMO3 also N-oxygenated tyramine to give exclusively the trans oxime.	Tyramine	250-258	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	227-231
9282832-7	1997	The results suggested that tyramine was sequentially N-oxygenated in the presence of pig and human liver microsomes and cDNA-expressed FMO3 to the hydroxylamine and then to the di-N-hydroxylamine that was spontaneously dehydrated to the trans oxime.	Tyramine	27-35	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	135-139
9288939-6	1997	THT follows Michaelis-Menten kinetics in the presence of low concentrations of feruloyl-CoA but negative cooperativity occurs when this concentration increases above 2.5 microM, resulting in a marked decrease of the affinity for tyramine.	Tyramine	229-237	tyramine N-feruloyltransferase 4/11	Nicotiana tabacum	0-3
9379445-10	1997	Molecular simulations of the receptor--ligand complex yielded structures in which the tyramine moiety or opioid "message" of dynorphin is bound within a conserved aromatic pocket in the transmembrane domain while the helical portion contacted residues in EL2 and in the extracellular end of transmembrane helices 6 and 7.	Tyramine	86-94	spectrin alpha, erythrocytic 1	Homo sapiens	255-258
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	98-106	monoamine oxidase A	Rattus norvegicus	170-175
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	98-106	monoamine oxidase A	Rattus norvegicus	170-173
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	256-264	monoamine oxidase A	Rattus norvegicus	170-175
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	256-264	monoamine oxidase A	Rattus norvegicus	170-173
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	256-264	monoamine oxidase A	Rattus norvegicus	170-175
9258353-6	1997	This is in contrast to a large blood pressure rise in rats pretreated with phenelzine followed by tyramine, and in accord with the belief that an inhibitor selective for MAO A which is reversibly bound to the enzyme and therefore displaced by any ingested tyramine will not lead to the "cheese effect" (hypertension during treatment with MAO inhibitors usually caused by ingestion of foods containing tyramine).	Tyramine	256-264	monoamine oxidase A	Rattus norvegicus	170-173
31026895-9	1997	Tyramine production between 5 and 15 mg/liter was related to Pediococcus spp.	Tyramine	0-8	histocompatibility minor 13	Homo sapiens	73-76
31026895-13	1997	Determination of tyramine levels in beer was found to be a reliable indicator of the degree of contamination by Pediococcus spp.	Tyramine	17-25	histocompatibility minor 13	Homo sapiens	124-127
9050018-21	1997	tyramine) by beta 1-adrenoceptor-mediated positive inotropic effects.	Tyramine	0-8	adrenoceptor beta 1	Homo sapiens	13-32
8914926-0	1996	The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA.	Tyramine	18-26	monoamine oxidase A	Rattus norvegicus	30-49
9025956-6	1997	Following preincubation of rat liver homogenates with selective monoamine oxidase (MAO)-A and -B inhibitors, kinetic constants were obtained for metabolism of the mixed substrate, p-tyramine.	Tyramine	180-190	monoamine oxidase A	Rattus norvegicus	64-96
9156408-0	1997	Pharmacokinetic properties of LMW-heparin-tyramine fractions with high or low affinity to antithrombin III in the rat.	Tyramine	42-50	serpin family C member 1	Rattus norvegicus	90-106
8914926-2	1996	In this study, we examined whether the H2O2 formed during the two-electron oxidation of tyramine [4-(2-aminoethyl)phenol] (a substrate for monoamine oxidases A/B) may contribute to the intramitochondrial steady-state concentration of H2O2 ([H2O2]ss) and, thus, be involved in the oxidative impairment of mitochondrial matrix components.	Tyramine	88-96	monoamine oxidase A	Rattus norvegicus	139-161
8914926-2	1996	In this study, we examined whether the H2O2 formed during the two-electron oxidation of tyramine [4-(2-aminoethyl)phenol] (a substrate for monoamine oxidases A/B) may contribute to the intramitochondrial steady-state concentration of H2O2 ([H2O2]ss) and, thus, be involved in the oxidative impairment of mitochondrial matrix components.	Tyramine	98-120	monoamine oxidase A	Rattus norvegicus	139-161
8823904-1	1996	The reducing end C-1 of (1-->4)-linked alpha-D-oligogalacturonides (oligogalacturonides), with degrees of polymerization (dp) 3 and 13, was coupled to tyramine via reductive amination in the presence of sodium cyanoborohydride.	Tyramine	154-162	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	17-20
8695909-6	1996	The maoA gene forms an operon with the maoC gene, which has similarity to a dehydrogenase involved in the tyramine metabolism.	Tyramine	106-114	monoamine oxidase A	Homo sapiens	4-8
8695909-1	1996	Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA.	Tyramine	56-64	monoamine oxidase B	Homo sapiens	135-151
8695909-1	1996	Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA.	Tyramine	56-64	monoamine oxidase A	Homo sapiens	201-205
8532118-3	1995	Total MAO activity measured using tyramine, increased postnatally up to 24 weeks of age and attained a plateau afterward.	Tyramine	34-42	monoamine oxidase A	Rattus norvegicus	6-9
8861736-1	1996	The objective of this study was to assess the tyramine pressor sensitivity during combined administration of selective and reversible inhibitors of monoamine oxidase A and B, viz.	Tyramine	46-54	monoamine oxidase A	Homo sapiens	148-173
8861736-14	1996	The low amount of oral tyramine needed (51 + or - 20 mg) to induce relevant increases in blood pressure indicates that dietary precautions are needed when both MAO-A and B are inhibited by 2 reversible inhibitors.	Tyramine	23-31	monoamine oxidase A	Homo sapiens	160-171
8573115-3	1996	Moreover the enzymatic activity of MAO-B towards phenylethylamine and tyramine is also suppressed after this immunoprecipitation, contrary to the MAO-A activity towards 5-hydroxy-tryptamine.	Tyramine	70-78	monoamine oxidase B	Homo sapiens	35-40
8920635-8	1996	For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes.	Tyramine	71-79	amine oxidase, copper containing 3	Rattus norvegicus	119-123
8920635-8	1996	For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes.	Tyramine	71-79	amine oxidase, copper containing 3	Rattus norvegicus	193-197
8920635-8	1996	For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes.	Tyramine	71-79	amine oxidase copper containing 2	Homo sapiens	193-197
8546710-8	1996	The Km of tyramine for native and recombinant human enzymes are virtually the same but higher than bovine DBH by about 3-fold.	Tyramine	10-18	dopamine beta-hydroxylase	Bos taurus	106-109
7582398-2	1995	This angiotensin II/norepinephrine interaction was investigated in man by examining the effect of enalapril pretreatment (5 mg for 5 days) on the renal response to a low non-pressor dose of intravenous tyramine 4 micrograms/kg/min for 120 min in 8 healthy subjects undergoing water diuresis.	Tyramine	202-210	angiotensinogen	Homo sapiens	5-19
7896069-0	1994	Altered alpha-adrenergic responses of vas deferens to noradrenaline and tyramine from rats with short- and long-term alloxan diabetes.	Tyramine	72-80	arginine vasopressin	Rattus norvegicus	38-41
7585347-4	1995	beta 3AR agonists (BRL 37344 and CGP 12177A) did not produce vasorelaxation, although tyramine could compete for cyanopindolol binding to murine L cells expressing human beta 2AR or beta 3AR.	Tyramine	86-94	adrenoceptor beta 3	Homo sapiens	182-190
7727409-2	1995	The resonance Raman spectra of hTH1 complexed with dopamine, noradrenaline, tyramine, and catechol have been studied and compared to those obtained for TH isolated from bovine adrenal glands or rat phaeochromocytoma tissue.	Tyramine	76-84	negative elongation factor complex member C/D	Homo sapiens	31-35
8584672-3	1995	Both lysyl oxidase and SSAO catalyze the oxidation of tyramine with removal of the pro-S hydrogen from C-1 of this substrate.	Tyramine	54-62	amine oxidase copper containing 3	Homo sapiens	23-27
7955818-1	1994	The effects of monoamine oxidase B (MAO-B) inhibition by mofegiline on the pharmacokinetics of p-tyramine and its major metabolite, p-hydroxyphenylacetic acid, were investigated in 24 healthy male volunteers.	Tyramine	95-105	monoamine oxidase B	Homo sapiens	36-41
7896069-5	1994	For this purpose, intrinsic activities (alpha E value) and apparent affinity constants (pD2 value) for contractile effects of noradrenaline and tyramine in the isolated rat vas deferens were calculated in normal rats and rats with short- and long-term alloxan diabetes.	Tyramine	144-152	arginine vasopressin	Rattus norvegicus	173-176
7896069-8	1994	By contrast, apparent affinity constants for contractile effects of tyramine in the isolated rat vas deferens were attenuated due to both short- and long-term alloxan diabetes.	Tyramine	68-76	arginine vasopressin	Rattus norvegicus	97-100
7896069-9	1994	Intrinsic activities for both noradrenaline- and tyramine-induced contractions of rat vas deferens, however, were increased due to short-term diabetes and decreased due to long-term diabetes.	Tyramine	49-57	arginine vasopressin	Rattus norvegicus	86-89
7931253-3	1994	Sensitivity to orally administered tyramine was determined under fasting conditions before and after drug administration and the doses of tyramine yielding a 30 mmHg increase of SBP (PD30) compared.	Tyramine	138-146	selenium binding protein 1	Homo sapiens	178-181
8151003-1	1994	A case report of a hypertensive crisis resulting from the ingestion of tap beer in a patient on an irreversible monamine oxidase inhibitor (MAOI; phenelzine) stimulated the investigation of different kinds of beer for tyramine concentration.	Tyramine	218-226	nuclear RNA export factor 1	Homo sapiens	71-74
8151003-2	1994	The objective was to determine the tyramine concentration in tap and bottled beers.	Tyramine	35-43	nuclear RNA export factor 1	Homo sapiens	61-64
12231940-6	1993	The study of tyramine structure-activity relationships further suggested that the toxicity of tyramine might be due to the formation of indolequinones after oxidation by PPO.	Tyramine	13-21	protoporphyrinogen oxidase, chloroplastic	Nicotiana tabacum	170-173
8255365-1	1993	The behavior of inhibitors of monoamine oxidase-A (MAO-A) is considered in terms of the possibility of having an effective antidepressant that does not give rise to hypertensive interactions with dietary tyramine.	Tyramine	204-212	monoamine oxidase A	Rattus norvegicus	51-56
8255365-4	1993	Selective inhibition of MAO-A by clorgyline results in a large increase in the amount of unchanged tyramine transported, whereas selective inhibition of MAO-B with L-deprenyl (selegiline) has no significant effect.	Tyramine	99-107	monoamine oxidase A	Rattus norvegicus	24-29
8255365-5	1993	The behavior of reversible MAO-A inhibitors can significantly reduce, but not entirely eliminate, these effects on the intestinal metabolism of tyramine, but only if the inhibition is competitive in nature.	Tyramine	144-152	monoamine oxidase A	Rattus norvegicus	27-32
8216383-5	1993	The application of the procedure to assay the oxidation of benzylamine, tyramine and 2-n-pentylaminoacetamide (milacemide) by a crude mitochondrial preparation from rat liver and purified ox liver MAO-B is demonstrated.	Tyramine	72-80	monoamine oxidase B	Rattus norvegicus	197-202
12231940-8	1993	THT was undetectable in calli grown on 2,4-dichlorophenoxyacetic acid but very active in tyramine-resistant crown gall cultures.	Tyramine	89-97	tyramine N-feruloyltransferase 4/11	Nicotiana tabacum	0-3
12231940-6	1993	The study of tyramine structure-activity relationships further suggested that the toxicity of tyramine might be due to the formation of indolequinones after oxidation by PPO.	Tyramine	94-102	protoporphyrinogen oxidase, chloroplastic	Nicotiana tabacum	170-173
8254175-10	1993	Furthermore, alpha-trinositol treatment completely inhibited the potentiation induced by neuropeptide Y (0.1 micrograms/min for 30 min) of the blood pressure responses to intravenous bolus injections of noradrenaline (20 ng), tyramine (40 micrograms) or angiotensin II (10 ng).	Tyramine	226-234	neuropeptide Y	Rattus norvegicus	89-103
8482079-1	1993	The specific adrenal dopamine-beta-hydroxylase activity measured in cat and rat was: (1) two times higher in cat than in rat; (2) significantly enhanced by ascorbate (up to 5 mM) that acts as a major activator; (3) differently affected by exogenous copper added to the incubation medium, leading to a decrease with large concentrations; and (4) similar, according to the kinetic parameters, thereby demonstrating a greater affinity for ascorbate than for tyramine.	Tyramine	455-463	dopamine beta-hydroxylase	Rattus norvegicus	21-46
8365114-7	1993	In the inhibition studies with selective MAO-A and MAO-B inhibitors, clorgyline and deprenyl, deamination of 5-HT, Bz and Tyr in both tissues was induced by MAO-A alone, MAO-B alone and both forms of the enzyme, respectively, indicating the same substrate specificity as that in rats.	Tyramine	122-125	monoamine oxidase A	Rattus norvegicus	41-46
8365114-7	1993	In the inhibition studies with selective MAO-A and MAO-B inhibitors, clorgyline and deprenyl, deamination of 5-HT, Bz and Tyr in both tissues was induced by MAO-A alone, MAO-B alone and both forms of the enzyme, respectively, indicating the same substrate specificity as that in rats.	Tyramine	122-125	monoamine oxidase B	Rattus norvegicus	51-56
8365114-7	1993	In the inhibition studies with selective MAO-A and MAO-B inhibitors, clorgyline and deprenyl, deamination of 5-HT, Bz and Tyr in both tissues was induced by MAO-A alone, MAO-B alone and both forms of the enzyme, respectively, indicating the same substrate specificity as that in rats.	Tyramine	122-125	monoamine oxidase A	Rattus norvegicus	157-162
8365114-7	1993	In the inhibition studies with selective MAO-A and MAO-B inhibitors, clorgyline and deprenyl, deamination of 5-HT, Bz and Tyr in both tissues was induced by MAO-A alone, MAO-B alone and both forms of the enzyme, respectively, indicating the same substrate specificity as that in rats.	Tyramine	122-125	monoamine oxidase B	Rattus norvegicus	170-175
8389852-0	1993	Endothelium- and beta-2 adrenoceptor-independent relaxation of rat aorta by tyramine and certain other phenylethylamines.	Tyramine	76-84	adrenoceptor beta 2	Rattus norvegicus	17-36
8389852-10	1993	It is suggested that at high concentrations tyramine and related phenylethylamines cause endothelium- and beta-2 adrenoceptor independent vasorelaxation either via specific tyramine receptors or nonselectively.	Tyramine	44-52	adrenoceptor beta 2	Rattus norvegicus	106-125
8461050-3	1993	p-Nitrophenol, a prototype substrate of human P-PST form, inhibits MST at micromolar concentration while millimolar concentrations of dopamine and tyramine, substrates of human M-(monoamine)-PST, are required to elicit a similar degree of inhibition.	Tyramine	147-155	sulfotransferase family 1A member 1	Homo sapiens	46-51
8313392-1	1993	Severe side effects such as hepatotoxicity and potentiation of the sympathomimetic action of tyramine ("the cheese effect") caused the withdrawal of nonselective irreversible monoamine oxidase (MAO) inhibitors from use in psychiatric therapy.	Tyramine	93-101	monoamine oxidase A	Rattus norvegicus	175-192
8313392-1	1993	Severe side effects such as hepatotoxicity and potentiation of the sympathomimetic action of tyramine ("the cheese effect") caused the withdrawal of nonselective irreversible monoamine oxidase (MAO) inhibitors from use in psychiatric therapy.	Tyramine	93-101	monoamine oxidase A	Rattus norvegicus	194-197
8313394-3	1993	However, BW 1370U87 differs from most other MAO inhibitors in that its mechanism of action follows simple competitive kinetics, so that an unusually high concentration of tyramine in peripheral tissues may displace the inhibitor from MAO-A sites in the intestine and liver.	Tyramine	171-179	monoamine oxidase A	Homo sapiens	234-239
8313392-4	1993	Being reversibly bound to MAO, these drugs may be displaced from their binding site in the intestine by ingested, indirectly sympathomimetic amines such as tyramine, thus avoiding the initiation of the hypertensive crises.	Tyramine	156-164	monoamine oxidase A	Rattus norvegicus	26-29
8313396-4	1993	The introduction of reversible inhibitors of monoamine oxidase-A (RIMAs) has greatly reduced both the number and severity of these interactions and, in particular, the risk of hypertensive crises following the ingestion of tyramine (the "cheese effect").	Tyramine	223-231	monoamine oxidase A	Homo sapiens	45-64
8390270-1	1993	The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors.	Tyramine	96-104	monoamine oxidase A	Homo sapiens	171-196
8390270-1	1993	The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors.	Tyramine	96-104	monoamine oxidase A	Homo sapiens	283-288
8390270-1	1993	The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors.	Tyramine	96-104	monoamine oxidase B	Homo sapiens	312-317
1609337-6	1992	The reversible inhibitors of monoamine oxidase A (RIMAs) are a group of drugs that, by producing inhibition selectively of monoamine oxidase A (MOA-A), still allow metabolism of tyramine by MAO-B.	Tyramine	178-186	monoamine oxidase A	Homo sapiens	29-48
1397011-0	1992	Displacement of in vivo binding of [3H]brofaromine to rat intestinal monoamine oxidase A by orally administered tyramine.	Tyramine	112-120	monoamine oxidase A	Rattus norvegicus	69-88
1397011-1	1992	The reversibility of the interaction of inhibitors with monoamine oxidase (MAO) is thought to provide a safety valve with respect to tyramine potentiation.	Tyramine	133-141	monoamine oxidase A	Rattus norvegicus	56-73
1397011-1	1992	The reversibility of the interaction of inhibitors with monoamine oxidase (MAO) is thought to provide a safety valve with respect to tyramine potentiation.	Tyramine	133-141	monoamine oxidase A	Rattus norvegicus	75-78
1637818-5	1992	The preferred mode of tyramine oxidation was found to occur with the loss of pro-S proton at C-1, coupled with solvent exchange into C-2, a pattern which has not been observed for any copper amine oxidase examined to date.	Tyramine	22-30	complement C2	Bos taurus	133-136
1397011-5	1992	It was also found that tyramine was relatively more effective in partially MAO-inhibited rats.	Tyramine	23-31	monoamine oxidase A	Rattus norvegicus	75-78
1609337-6	1992	The reversible inhibitors of monoamine oxidase A (RIMAs) are a group of drugs that, by producing inhibition selectively of monoamine oxidase A (MOA-A), still allow metabolism of tyramine by MAO-B.	Tyramine	178-186	monoamine oxidase A	Homo sapiens	123-142
1609337-6	1992	The reversible inhibitors of monoamine oxidase A (RIMAs) are a group of drugs that, by producing inhibition selectively of monoamine oxidase A (MOA-A), still allow metabolism of tyramine by MAO-B.	Tyramine	178-186	monoamine oxidase B	Homo sapiens	190-195
1560185-10	1992	[125I]Tyramine-MIB reactivity and sensitivity exceeds that of protein-tyrosyl radioiodination by the chloramine-T procedure and is expected to assist in studying minute quantities of SH-proteins.	Tyramine	6-14	MIB E3 ubiquitin protein ligase 1	Homo sapiens	15-18
1667926-6	1991	Only class III conformers for both c-ORN and c-PEN, having tyramine dihedral angles chi 1 = 150 degrees +/- 30 degrees and chi 2 = -155 degrees +/- 20 degrees, had significant structural and conformational properties that were mutually compatible while respecting the PEO vector space.	Tyramine	59-67	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	47-50
1349516-2	1992	Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase).	Tyramine	324-332	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
1349516-2	1992	Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase).	Tyramine	324-332	butyrylcholinesterase	Homo sapiens	68-89
1349516-3	1992	Tyramine activation was unaffected in the presence of the selective acetylcholinesterase inhibitor BW284C51 whereas it was abolished in the presence of the selective butyrylcholinesterase inhibitor ethopropazine, suggesting the presence of both types of aryl acylamidases in amniotic fluid, one associated with acetylcholinesterase and the other associated with butyrylcholinesterase.	Tyramine	0-8	butyrylcholinesterase	Homo sapiens	166-187
1349516-3	1992	Tyramine activation was unaffected in the presence of the selective acetylcholinesterase inhibitor BW284C51 whereas it was abolished in the presence of the selective butyrylcholinesterase inhibitor ethopropazine, suggesting the presence of both types of aryl acylamidases in amniotic fluid, one associated with acetylcholinesterase and the other associated with butyrylcholinesterase.	Tyramine	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	311-331
1349516-3	1992	Tyramine activation was unaffected in the presence of the selective acetylcholinesterase inhibitor BW284C51 whereas it was abolished in the presence of the selective butyrylcholinesterase inhibitor ethopropazine, suggesting the presence of both types of aryl acylamidases in amniotic fluid, one associated with acetylcholinesterase and the other associated with butyrylcholinesterase.	Tyramine	0-8	butyrylcholinesterase	Homo sapiens	362-383
1356240-5	1992	+/- 7.5 pmol tritiated H2O/mg protein/min) and a higher Km of MAO (59 +/- 2.9 nM tyramine) than normal animals (46 +/- 1.7 nM tyramine).	Tyramine	81-89	monoamine oxidase A	Rattus norvegicus	62-65
1546143-4	1992	Potentiation of the cardiovascular effects of tyramine is less pronounced after taking moclobemide than after irreversible MAO-A inhibitors.	Tyramine	46-54	monoamine oxidase A	Homo sapiens	123-128
1483487-1	1992	An open study was carried out to examine the effect of moclobemide, a new antidepressant reversible inhibitor of MAO-A, on the pressor response induced by oral tyramine added to meals of different lipid and protein composition, and to correlate the blood pressure increase in the tyramine test with that obtained during an exercise test.	Tyramine	160-168	monoamine oxidase A	Homo sapiens	113-118
1331579-2	1992	To improve the temporal and spatial control of the membrane potential, sodium currents (INa) were recorded in 45.5 mM [Na+]o at 10 degrees C. Both tyramine and NFT (1-100 microM) induced a concentration-dependent decrease in INa evoked from a holding potential of -80 mV without affecting a change in either the time to peak or the time constant for the falling phase of INa.	Tyramine	147-155	internexin neuronal intermediate filament protein alpha	Homo sapiens	88-91
1331579-2	1992	To improve the temporal and spatial control of the membrane potential, sodium currents (INa) were recorded in 45.5 mM [Na+]o at 10 degrees C. Both tyramine and NFT (1-100 microM) induced a concentration-dependent decrease in INa evoked from a holding potential of -80 mV without affecting a change in either the time to peak or the time constant for the falling phase of INa.	Tyramine	147-155	internexin neuronal intermediate filament protein alpha	Homo sapiens	225-228
1331579-2	1992	To improve the temporal and spatial control of the membrane potential, sodium currents (INa) were recorded in 45.5 mM [Na+]o at 10 degrees C. Both tyramine and NFT (1-100 microM) induced a concentration-dependent decrease in INa evoked from a holding potential of -80 mV without affecting a change in either the time to peak or the time constant for the falling phase of INa.	Tyramine	147-155	internexin neuronal intermediate filament protein alpha	Homo sapiens	225-228
1331579-4	1992	The finding that both tyramine and NFT decreased INa when activated maximally, from a holding potential of -120 mV, indicates that the amplitude of INa can be reduced independently of a change in the kinetics of the current.	Tyramine	22-30	internexin neuronal intermediate filament protein alpha	Homo sapiens	49-52
1331579-4	1992	The finding that both tyramine and NFT decreased INa when activated maximally, from a holding potential of -120 mV, indicates that the amplitude of INa can be reduced independently of a change in the kinetics of the current.	Tyramine	22-30	internexin neuronal intermediate filament protein alpha	Homo sapiens	148-151
1609114-6	1992	In the intestinal tract tyramine is mainly metabolized by MAO-A.	Tyramine	24-32	monoamine oxidase A	Homo sapiens	58-63
1907840-3	1991	We have therefore investigated the effects of oral lithium carbonate (500 mg) on the natriuretic response to a pressor dose of tyramine (15 micrograms kg-1 min-1) in six normal volunteers.	Tyramine	127-135	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
1759390-6	1991	After selective inhibition of MAO-A by chlorgyline the order of MAO-B-dependent effects of biogenic amines on mitochondrial enzymes studied was as follows: tyramine greater than or equal to 2-phenylethylamine much greater than serotonin.	Tyramine	156-164	monoamine oxidase B	Homo sapiens	64-69
1759390-7	1991	In deprenyl pretreated mitochondria the potency of MAO-A-dependent effects of these amines was: serotonin greater than tyramine much greater than much greater than 2-phenylethylamine.	Tyramine	119-127	monoamine oxidase A	Homo sapiens	51-56
1741773-8	1991	The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23).	Tyramine	146-154	monoamine oxidase A	Homo sapiens	11-16
1741773-8	1991	The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23).	Tyramine	146-154	monoamine oxidase B	Homo sapiens	36-41
1743243-0	1991	The effect of angiotensin II on haemodynamic and plasma noradrenaline responses to tyramine infusion in man.	Tyramine	83-91	angiotensinogen	Homo sapiens	14-28
1884793-1	1991	In experiments on conscious normotensive male Wistar rats the new antidepressants, reversible MAO-A inhibitors, pyrazidole and incazane, as well as moclobemid increased the pressor effect of orally administered tyramine.	Tyramine	211-219	monoamine oxidase A	Rattus norvegicus	94-99
1884793-4	1991	The potentiation by the studied MAO-A inhibitors of the pressor effect of tyramine reflects the inhibition of the activity of MAO-A and the first-pass metabolism of tyramine in the gut and liver, as well as the inhibition of intraneuronal MAO activity in noradrenergic nerve endings and the potentiation of sympathetic activity.	Tyramine	74-82	monoamine oxidase A	Rattus norvegicus	32-37
1884793-4	1991	The potentiation by the studied MAO-A inhibitors of the pressor effect of tyramine reflects the inhibition of the activity of MAO-A and the first-pass metabolism of tyramine in the gut and liver, as well as the inhibition of intraneuronal MAO activity in noradrenergic nerve endings and the potentiation of sympathetic activity.	Tyramine	74-82	monoamine oxidase A	Rattus norvegicus	126-131
1884793-4	1991	The potentiation by the studied MAO-A inhibitors of the pressor effect of tyramine reflects the inhibition of the activity of MAO-A and the first-pass metabolism of tyramine in the gut and liver, as well as the inhibition of intraneuronal MAO activity in noradrenergic nerve endings and the potentiation of sympathetic activity.	Tyramine	74-82	monoamine oxidase A	Rattus norvegicus	32-35
1884793-4	1991	The potentiation by the studied MAO-A inhibitors of the pressor effect of tyramine reflects the inhibition of the activity of MAO-A and the first-pass metabolism of tyramine in the gut and liver, as well as the inhibition of intraneuronal MAO activity in noradrenergic nerve endings and the potentiation of sympathetic activity.	Tyramine	165-173	monoamine oxidase A	Rattus norvegicus	32-37
1884793-4	1991	The potentiation by the studied MAO-A inhibitors of the pressor effect of tyramine reflects the inhibition of the activity of MAO-A and the first-pass metabolism of tyramine in the gut and liver, as well as the inhibition of intraneuronal MAO activity in noradrenergic nerve endings and the potentiation of sympathetic activity.	Tyramine	165-173	monoamine oxidase A	Rattus norvegicus	32-35
1905757-2	1991	By using tyramine as a substrate, the presence of MAO in these cells was demonstrated.	Tyramine	9-17	monoamine oxidase A	Rattus norvegicus	50-53
1817165-4	1991	Like the observations on adrenergic neurones, non-selective and selective MAO-A inhibitors potentiate the catecholamine-releasing property of tyramine in PC12 cells.	Tyramine	142-150	monoamine oxidase A	Rattus norvegicus	74-79
1817165-8	1991	In the final analysis the inter-relationship between MAO-A activity and the presence of tyramine-releasable pool of catecholamines in adrenergic neurons and PC12 cells may have a genetic basis and could be important in illuminating the differentiation of neural crest into adrenergic neurones and adrenal medulla on the one hand and chromaffin cells to PC12 cells on the other.	Tyramine	88-96	monoamine oxidase A	Rattus norvegicus	53-58
22282124-7	1991	The MAO-B inhibitor, selegiline (5 mg once daily), also lowered the oral tyramine threshold significantly.	Tyramine	73-81	monoamine oxidase B	Homo sapiens	4-9
1997791-4	1991	An increase in the perfusate concentration of p-tyrosine resulted in a significant increase in p-tyramine production that was blocked by the addition of NSD-1015, an inhibitor of aromatic-1-amino decarboxylase (AADC).	Tyramine	95-105	dopa decarboxylase	Rattus norvegicus	179-209
1997791-4	1991	An increase in the perfusate concentration of p-tyrosine resulted in a significant increase in p-tyramine production that was blocked by the addition of NSD-1015, an inhibitor of aromatic-1-amino decarboxylase (AADC).	Tyramine	95-105	dopa decarboxylase	Rattus norvegicus	211-215
1997791-5	1991	We conclude p-tyrosine is the precursor for the renal production of p-tyramine, renal AADC catalyzes the formation of urinary p-tyramine, synthesized p-tyramine is predominantly excreted in the urine, and p-tyramine synthesis is modulated by the arterial delivery of p-tyrosine to the kidney.	Tyramine	68-78	dopa decarboxylase	Rattus norvegicus	86-90
1997791-5	1991	We conclude p-tyrosine is the precursor for the renal production of p-tyramine, renal AADC catalyzes the formation of urinary p-tyramine, synthesized p-tyramine is predominantly excreted in the urine, and p-tyramine synthesis is modulated by the arterial delivery of p-tyrosine to the kidney.	Tyramine	126-136	dopa decarboxylase	Rattus norvegicus	86-90
1997791-5	1991	We conclude p-tyrosine is the precursor for the renal production of p-tyramine, renal AADC catalyzes the formation of urinary p-tyramine, synthesized p-tyramine is predominantly excreted in the urine, and p-tyramine synthesis is modulated by the arterial delivery of p-tyrosine to the kidney.	Tyramine	126-136	dopa decarboxylase	Rattus norvegicus	86-90
1997791-5	1991	We conclude p-tyrosine is the precursor for the renal production of p-tyramine, renal AADC catalyzes the formation of urinary p-tyramine, synthesized p-tyramine is predominantly excreted in the urine, and p-tyramine synthesis is modulated by the arterial delivery of p-tyrosine to the kidney.	Tyramine	126-136	dopa decarboxylase	Rattus norvegicus	86-90
2299343-0	1990	Monoamine oxidase (MAO)-A but not MAO-B inhibitors potentiate tyramine-induced catecholamine release from PC12 cells.	Tyramine	62-70	monoamine oxidase A	Rattus norvegicus	0-25
2251787-2	1990	It was shown that in experimental catatonia (as compared with rats of the corresponding control group) there was a dramatic increase in the brain stem of the rate of oxidative deamination of beta-phenylethylamine catalyzed by MAO-III; there was also a statistically significant (albeit less expressed than in the experiments with beta-phenylethylamine) increase in the rate of deamination of tyramine and a decrease in the rate of deamination of serotonin.	Tyramine	392-400	monoamine oxidase A	Rattus norvegicus	226-229
2251787-3	1990	In the systems with MAO-II beta we detected statistically significant increase in the rates of deamination of tyramine and beta-phenylethylamine in experimental catatonia as compared with corresponding control.	Tyramine	110-118	monoamine oxidase A	Rattus norvegicus	20-23
2306475-3	1990	HYD and IAA show slope and intercept mixed-type allosteric inhibition of dopamine beta-hydroxylase with respect to tyramine.	Tyramine	115-123	dopamine beta-hydroxylase	Bos taurus	73-98
2306475-4	1990	QCA shows allosteric uncompetitive inhibition of dopamine beta-hydroxylase with respect to tyramine.	Tyramine	91-99	dopamine beta-hydroxylase	Bos taurus	49-74
2306475-6	1990	HP and BI show linear mixed-type while IQCA shows linear uncompetitive inhibition of dopamine beta-hydroxylase with respect to tyramine.	Tyramine	127-135	dopamine beta-hydroxylase	Bos taurus	85-110
2306475-8	1990	These findings are consistent with a uni-uni-ping-pong-ter-bi kinetic mechanism for dopamine beta-hydroxylase that involves a ternary enzyme-ascorbate-tyramine-oxygen complex.	Tyramine	151-159	dopamine beta-hydroxylase	Bos taurus	84-109
2323731-5	1990	The MAO A inhibitor clorgyline (10(-9) M) produced a strong inhibition on the iodotyrosine formation induced by tyramine, 5-HT and PEA.	Tyramine	112-120	monoamine oxidase A	Bos taurus	4-9
2299343-2	1990	Selective monoamine oxidase (MAO)-A (clorgyline and moclobemide) and not MAO-B inhibitors (l-deprenyl, AGN 1135, and Ro 16-6491) potentiate the catecholamine-releasing action of tyramine significantly more than that of K+.	Tyramine	178-186	monoamine oxidase A	Rattus norvegicus	10-35
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Tyramine	20-28	monoamine oxidase A	Rattus norvegicus	82-87
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Tyramine	20-28	monoamine oxidase A	Rattus norvegicus	134-139
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Tyramine	166-174	monoamine oxidase A	Rattus norvegicus	82-87
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Tyramine	166-174	monoamine oxidase A	Rattus norvegicus	134-139
2248084-6	1990	Potentiation of the tyramine pressor effect is mainly influenced by the irreversibility and degree of MAO-A inhibition.	Tyramine	20-28	monoamine oxidase A	Homo sapiens	102-107
2248084-7	1990	Tyramine sensitivity was raised (a factor of 10-30) by all irreversible MAO inhibitors in doses inhibiting MAO-A; it diminished with increasing reversibility.	Tyramine	0-8	monoamine oxidase A	Homo sapiens	107-112
2153484-1	1990	In this rapid, simple, and convenient enzymatic method for measurement of tyrosine in plasma, tyrosine is converted to tyramine by action of tyrosine decarboxylase (EC 4.1.1.25) and the tyramine produced is oxidized to p-hydroxybenzyl aldehyde and hydrogen peroxide by action of tyramine oxidase (EC 1.4.3.9).	Tyramine	119-127	monoamine oxidase B	Homo sapiens	279-295
2248060-6	1990	This effect was almost completely eliminated by desipramine, suggesting that coadministration of a norepinephrine uptake inhibitor with a reversible MAO inhibitor is likely to reduce the risk of tyramine-induced hypertensive crisis.	Tyramine	195-203	monoamine oxidase A	Rattus norvegicus	149-152
2248079-5	1990	Interaction of MAO inhibitors and monoamine reuptake inhibitors with tyramine is discussed on the basis of experiments in conscious rats.	Tyramine	69-77	monoamine oxidase A	Rattus norvegicus	15-18
2127505-0	1990	The effect of various monoamine oxidase (MAO) inhibitors on the response of blood pressure of rats and cats to tyramine.	Tyramine	111-119	monoamine oxidase A	Rattus norvegicus	22-39
2127505-0	1990	The effect of various monoamine oxidase (MAO) inhibitors on the response of blood pressure of rats and cats to tyramine.	Tyramine	111-119	monoamine oxidase A	Rattus norvegicus	41-44
2127505-2	1990	It occurs mainly as a result of the interaction of MAO inhibitor with tyramine in foodstuffs.	Tyramine	70-78	monoamine oxidase A	Rattus norvegicus	51-54
2127505-3	1990	Anaesthetised rats and cats were used in order to investigate and compare the influence of the effect of tyramine by selective MAO type-B inhibitors with that produced by non-selective and A-selective MAO inhibitors on the one hand, and on the other hand, different MAO-B inhibitors with (-)deprenyl.	Tyramine	105-113	monoamine oxidase A	Rattus norvegicus	127-130
2127505-4	1990	(-)Deprenyl was the only one which inhibited the effect of tyramine in the experimental animals used, while other MAO inhibitors potentiated the tyramine effect.	Tyramine	145-153	monoamine oxidase A	Rattus norvegicus	114-117
2153484-1	1990	In this rapid, simple, and convenient enzymatic method for measurement of tyrosine in plasma, tyrosine is converted to tyramine by action of tyrosine decarboxylase (EC 4.1.1.25) and the tyramine produced is oxidized to p-hydroxybenzyl aldehyde and hydrogen peroxide by action of tyramine oxidase (EC 1.4.3.9).	Tyramine	186-194	monoamine oxidase B	Homo sapiens	279-295
34962369-0	2022	Interfacially Super-Assembled Tyramine-Modified Mesoporous Silica-Alumina Oxide Heterochannels for Label-Free Tyrosinase Detection.	Tyramine	30-38	tyrosinase	Homo sapiens	110-120
33232669-0	2020	Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans.	Tyramine	0-8	BZIP domain-containing protein	Caenorhabditis elegans	37-42
33232669-4	2020	Expression of xbp-1s in just two pairs of neurons that synthesize tyramine, the RIM and RIC interneurons, induced intestinal UPRER activation and extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons.	Tyramine	66-74	BZIP domain-containing protein	Caenorhabditis elegans	14-19
33232669-5	2020	In addition, we found that neuronal xbp-1s modulates feeding behavior and reproduction, dependent upon tyramine synthesis.	Tyramine	103-111	BZIP domain-containing protein	Caenorhabditis elegans	36-41
34959139-3	2022	The linear range of TYR-AuNPs LFIA was 0.25-5 ng mL-1 with the limit of detection (LOD) of 0.032 ng mL-1, and the LOD was 8-fold lower than that of the traditional AuNPs LFIA (0.26 ng mL-1).	Tyramine	20-23	L1 cell adhesion molecule	Mus musculus	49-53
34959139-3	2022	The linear range of TYR-AuNPs LFIA was 0.25-5 ng mL-1 with the limit of detection (LOD) of 0.032 ng mL-1, and the LOD was 8-fold lower than that of the traditional AuNPs LFIA (0.26 ng mL-1).	Tyramine	20-23	L1 cell adhesion molecule	Mus musculus	100-104
34959139-3	2022	The linear range of TYR-AuNPs LFIA was 0.25-5 ng mL-1 with the limit of detection (LOD) of 0.032 ng mL-1, and the LOD was 8-fold lower than that of the traditional AuNPs LFIA (0.26 ng mL-1).	Tyramine	20-23	L1 cell adhesion molecule	Mus musculus	184-188
34962369-4	2022	Herein, a functional nanofluidic heterochannel composed of an ultrathin tyramine-modified mesoporous silica layer (Tyr-MS) and alumina oxide (AAO) arrays is constructed by an interfacial super-assembly method.	Tyramine	72-80	tyrosinase	Homo sapiens	115-118
34952586-2	2021	Herein, based on the reformative tyramine signal amplification (TSA) enabled by molecular aptamer beacon (MAB) conversion, a label-free surface plasmon resonance (SPR) biosensor was proposed for highly sensitive and specific detection of HER2-positive exosomes.	Tyramine	33-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	238-242
34474093-4	2021	The DAO-1 showed a broad substrate selectivity with tyramine, histamine, putrescine and cadaverine being the most favored substrates.	Tyramine	52-60	amine oxidase copper containing 1	Homo sapiens	4-9
34784871-11	2021	Of monoamine oxidase B inhibitors, safinamide is the least susceptible for interaction with the tyramine-rich food, whereas selegiline and rasagiline may lose selectivity to monoamine oxidase B when administered in supratherapeutic doses.	Tyramine	96-104	monoamine oxidase B	Homo sapiens	3-22
34794563-8	2021	The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added.	Tyramine	18-26	tyrosinase	Homo sapiens	4-7
34794563-8	2021	The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added.	Tyramine	18-26	tyrosinase	Homo sapiens	264-267
35547777-2	2022	Here, we present a new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with antioxidant drug curcumin (Cur).	Tyramine	54-62	TATA box binding protein	Mus musculus	108-111
34766253-3	2021	Trace amine-associated receptor 1 (TAAR1), the most well characterized receptor in the TAAR family, has been shown to be potently activated by trace amines such as TYR and PEA.	Tyramine	164-167	trace amine associated receptor 1	Homo sapiens	0-33
34766253-3	2021	Trace amine-associated receptor 1 (TAAR1), the most well characterized receptor in the TAAR family, has been shown to be potently activated by trace amines such as TYR and PEA.	Tyramine	164-167	trace amine associated receptor 1	Homo sapiens	35-40
34605737-0	2021	Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine.	Tyramine	165-175	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	53-72
34256299-3	2021	In addition, a number of endogenous compounds have been shown to be substrates of CYP2D6 including trace amines in the brain such as tyramine and 5-methoxytryptamine as well as anandamide and progesterone.	Tyramine	133-141	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	82-88
34358444-7	2021	Tyramine inhibits a subset of feeding-promoting tyramine receptor (TyrR)-expressing neurons and activates P1 neurons, a known command center for courtship.	Tyramine	0-8	Tyramine receptor	Drosophila melanogaster	48-65
34358444-7	2021	Tyramine inhibits a subset of feeding-promoting tyramine receptor (TyrR)-expressing neurons and activates P1 neurons, a known command center for courtship.	Tyramine	0-8	Tyramine receptor	Drosophila melanogaster	67-71
34358444-9	2021	Therefore, TyrR and P1 neurons are oppositely modulated by starvation, via tyramine levels, and food availability.	Tyramine	75-83	Tyramine receptor	Drosophila melanogaster	11-15
34067451-3	2021	Herein, a novel nano-in-gel delivery system for vascular endothelial growth factor (VEGF), composed of star-shaped polyglutamic acid-VEGF nanoparticles in a tyramine-modified hyaluronic acid hydrogel (nano-VEGF-HA-TA), is investigated.	Tyramine	157-165	vascular endothelial growth factor A	Homo sapiens	48-82
34067451-3	2021	Herein, a novel nano-in-gel delivery system for vascular endothelial growth factor (VEGF), composed of star-shaped polyglutamic acid-VEGF nanoparticles in a tyramine-modified hyaluronic acid hydrogel (nano-VEGF-HA-TA), is investigated.	Tyramine	157-165	vascular endothelial growth factor A	Homo sapiens	84-88
34067451-3	2021	Herein, a novel nano-in-gel delivery system for vascular endothelial growth factor (VEGF), composed of star-shaped polyglutamic acid-VEGF nanoparticles in a tyramine-modified hyaluronic acid hydrogel (nano-VEGF-HA-TA), is investigated.	Tyramine	157-165	vascular endothelial growth factor A	Homo sapiens	133-137
34067451-3	2021	Herein, a novel nano-in-gel delivery system for vascular endothelial growth factor (VEGF), composed of star-shaped polyglutamic acid-VEGF nanoparticles in a tyramine-modified hyaluronic acid hydrogel (nano-VEGF-HA-TA), is investigated.	Tyramine	157-165	vascular endothelial growth factor A	Homo sapiens	206-210
35291811-11	2022	RESULTS: The changes in leg vascular resistance in response to tyramine (+289% versus +222%), sodium nitroprusside (-82% versus -78%) and acetylcholine (-40% versus -44%) infusion were not different between the 2 groups (P>0.05) and pannexin-1 blockade did not alter these variables (P>0.05).	Tyramine	63-71	pannexin 1	Homo sapiens	233-243
35164229-7	2022	Furthermore, chlorogenic acid, tyramine derivatives, and the mixture of the six identified major compounds significantly decreased IL-6 secretion by LPS-activated J774 cells.	Tyramine	31-39	interleukin 6	Mus musculus	131-135
2819332-2	1989	Semicarbazide-sensitive amine oxidase (SSAO) activity has been demonstrated in the isolated mesenteric arterial bed of the rat in vitro by studying the metabolism of benzylamine (Bz) and tyramine (Tyr) added to the perfusing fluid.	Tyramine	187-195	amine oxidase, copper containing 3	Rattus norvegicus	0-37
35126867-3	2022	METHODS: 3H-2-deoxyglucose uptake (2-DG) was determined in adipocytes from obese and lean rats in response to insulin or MAO and SSAO substrates such as tyramine and benzylamine.	Tyramine	153-161	amine oxidase, copper containing 3	Rattus norvegicus	129-133
35126867-7	2022	Tyramine and benzylamine activation of hexose uptake was vanadate-dependent and was also limited, while MAO was increased and SSAO decreased.	Tyramine	0-8	monoamine oxidase A	Rattus norvegicus	104-107
35126867-7	2022	Tyramine and benzylamine activation of hexose uptake was vanadate-dependent and was also limited, while MAO was increased and SSAO decreased.	Tyramine	0-8	amine oxidase, copper containing 3	Rattus norvegicus	126-130
35126867-11	2022	However, probably as a consequence of SSAO down-regulation, the glucose transport stimulation by tyramine is decreased as much as that of insulin in these insulin-resistant adipocytes.	Tyramine	97-105	amine oxidase, copper containing 3	Rattus norvegicus	38-42
2508758-1	1989	Microbial tyrosine decarboxylase (EC 4.1.1.25) and mammalian aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) catalyse the formation of tyramine from L-tyrosine.	Tyramine	137-145	dopa decarboxylase	Homo sapiens	61-96
2819333-3	1989	Very little MAO-B activity is found in homogenates of this tissue when Tyr is used as substrate.	Tyramine	71-74	monoamine oxidase B	Rattus norvegicus	12-17
35066863-3	2022	Although we have recently described that tyramine is antilipolytic in human adipocytes, no clear evidence has been reported about its effects on glucose transport in the same cell model, while tyramine mimics various insulin-like effects in rodent fat cells, such as activation of glucose transport, lipogenesis, and adipogenesis.	Tyramine	193-201	insulin	Homo sapiens	217-224
35066863-11	2022	In all, the oxidation of high doses of tyramine, already reported to inhibit lipolysis in human fat cells, also partially mimic another effect of insulin in these cells, the glucose uptake activation.	Tyramine	39-47	insulin	Homo sapiens	146-153
2619973-2	1989	Administration of moclobemide--a relatively short-acting, reversible inhibitor of monoamine oxidase-A (MAO-A)--to experimental animals potentiates the pressor responses to intravenously injected tyramine, but such effects are moderate, short-lived, and much less apparent when the tyramine is given orally.	Tyramine	195-203	monoamine oxidase A	Homo sapiens	103-108
2619973-2	1989	Administration of moclobemide--a relatively short-acting, reversible inhibitor of monoamine oxidase-A (MAO-A)--to experimental animals potentiates the pressor responses to intravenously injected tyramine, but such effects are moderate, short-lived, and much less apparent when the tyramine is given orally.	Tyramine	281-289	monoamine oxidase A	Homo sapiens	103-108
2819332-2	1989	Semicarbazide-sensitive amine oxidase (SSAO) activity has been demonstrated in the isolated mesenteric arterial bed of the rat in vitro by studying the metabolism of benzylamine (Bz) and tyramine (Tyr) added to the perfusing fluid.	Tyramine	187-195	amine oxidase, copper containing 3	Rattus norvegicus	39-43
2819332-2	1989	Semicarbazide-sensitive amine oxidase (SSAO) activity has been demonstrated in the isolated mesenteric arterial bed of the rat in vitro by studying the metabolism of benzylamine (Bz) and tyramine (Tyr) added to the perfusing fluid.	Tyramine	197-200	amine oxidase, copper containing 3	Rattus norvegicus	0-37
2819332-2	1989	Semicarbazide-sensitive amine oxidase (SSAO) activity has been demonstrated in the isolated mesenteric arterial bed of the rat in vitro by studying the metabolism of benzylamine (Bz) and tyramine (Tyr) added to the perfusing fluid.	Tyramine	197-200	amine oxidase, copper containing 3	Rattus norvegicus	39-43
2819332-11	1989	The metabolism of Tyr by homogenates of the rat mesenteric vascular bed was carried out by SSAO (60%) and MAO-A (40%) with very little contribution from MAO-B.	Tyramine	18-21	amine oxidase, copper containing 3	Rattus norvegicus	91-95
2819332-11	1989	The metabolism of Tyr by homogenates of the rat mesenteric vascular bed was carried out by SSAO (60%) and MAO-A (40%) with very little contribution from MAO-B.	Tyramine	18-21	monoamine oxidase A	Rattus norvegicus	106-111
2819332-12	1989	Homogenates from rats pretreated with MDL 72145 showed metabolism of Tyr by MAO-A only.	Tyramine	69-72	monoamine oxidase A	Rattus norvegicus	76-81
2795592-8	1989	Confirming this finding significantly lower tyramine doses were required to produce the same SBP increase in hypertensives than in the normotensive volunteers.	Tyramine	44-52	selenium binding protein 1	Homo sapiens	93-96
2503040-4	1989	The presence of MAO-B was corroborated by the inhibition of PEA oxidation with nanomolar deprenyl concentrations and by inhibition of TYR oxidation with high clorgyline concentrations, as well as by the simple sigmoid curve obtained in both cases.	Tyramine	134-137	monoamine oxidase B	Homo sapiens	16-21
2587673-3	1989	The present results in rats and the clinical trials provide evidence that moclobemide is an orally active MAO-A inhibitor which, due to its remarkably low tyramine potentiating pressor effects and to its lack of anticholinergic activity, has a very attractive pharmacological profile.	Tyramine	155-163	monoamine oxidase A	Rattus norvegicus	106-111
2770705-4	1989	A reciprocal relation was found to exist between inhibitory constants of 5-N-substituted amiloride analogues for monoamine oxidase A and the ratio of overflows of endogenous noradrenaline and 3,4-dihydroxyphenylethylene glycol from the isolated rat tail artery incubated in the presence of a 50 microM concentration of the analogue, when the tissue was exposed to 10 microM tyramine.	Tyramine	374-382	monoamine oxidase A	Rattus norvegicus	113-132
2587674-9	1989	The results suggest that the two reversible MAO-A inhibitors moclobemide and brofaromine carry a much reduced liability to tyramine-related hypertensive reactions.	Tyramine	123-131	monoamine oxidase A	Homo sapiens	44-49
2570842-2	1989	Hordenine was deaminated by rat liver MAO with a Michaelis constant of 479 microM and maximum velocity of 128 nmol (mg protein)-1 h-1 compared with 144 microM and 482 nmol (mg protein)-1 h-1 for tyramine.	Tyramine	195-203	monoamine oxidase A	Rattus norvegicus	38-41
2719723-9	1989	Direct evidence for metabolism by SSAO of some of the competing amines such as isoamylamine, phenylethylamine, tyramine and tryptamine was obtained by fluorimetric or radiochemical assays.	Tyramine	111-119	amine oxidase, copper containing 3	Rattus norvegicus	34-38
22156310-0	1989	Potentiation of the pressor effect of oral and intravenous tyramine during administration of the selective MAO-A inhibitor moclobemide in healthy volunteers.	Tyramine	59-67	monoamine oxidase A	Homo sapiens	107-112
2492810-2	1989	The endogenous material (F-1 and F-2) obtained after Bio-Gel P-2 gel filtration and silica column chromatography inhibited MAO in the monkey brain mitochondria toward 5-hydroxytryptamine (5-HT), beta-phenylethylamine (beta-PEA), tyramine and dopamine as substrates.	Tyramine	229-237	coagulation factor II, thrombin	Homo sapiens	25-36
2794993-10	1989	The results suggest that the two reversible MAO-A inhibitors Mocl and Brof may lessen the liability to TYR-related hypertensive reactions.	Tyramine	103-106	monoamine oxidase A	Homo sapiens	44-49
2913308-0	1989	Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.	Tyramine	57-65	phenylethanolamine N-methyltransferase	Homo sapiens	93-131
2913308-4	1989	p-Tyramine (10, Ki = 294 microM) was more potent than phenylethylamine (1, Ki = 854 microM) but m-tyramine (9, Ki = 1250 microM) was less potent than phenylethylamine as an inhibitor of PNMT.	Tyramine	0-10	phenylethanolamine N-methyltransferase	Homo sapiens	186-190
2913308-9	1989	The interaction of the p-hydroxyl group of the tyramine moiety may involve hydrogen bonding since the corresponding methyl ethers show a greatly reduced affinity for the active site of PNMT (Ki = 34 and 389 microM for methoxy analogues 28 and 35, compared to Ki = 4.7 and 111 microM for the corresponding phenolic analogues 14 and 23).	Tyramine	47-55	phenylethanolamine N-methyltransferase	Homo sapiens	185-189
3269534-0	1988	The effect of various MAO-B inhibitors on rabbit arterial strip response to tyramine.	Tyramine	76-84	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	22-27
3269534-3	1988	Thus the inhibition of noradrenaline-releasing effect of tyramine, a property favorable from the point of view of safety in clinical practice, is a specific feature of (-)deprenyl and not a more general characteristics of MAO-B inhibitors.	Tyramine	57-65	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	222-227
3368472-0	1988	Differential responsiveness of LH and prolactin to p-tyramine in male and female rats.	Tyramine	51-61	prolactin	Rattus norvegicus	38-47
2843627-2	1988	In the present work, we evaluated in unanesthetized normotensive rats the effect of NPY on blood pressure responsiveness not only to norepinephrine, but also to tyramine, a sympathomimetic agent acting indirectly to B-HT933, a selective alpha-2 adrenoceptor stimulant, to angiotensin II and vasopressin.	Tyramine	161-169	neuropeptide Y	Rattus norvegicus	84-87
2843627-6	1988	NPY significantly enhanced the pressor effect of norepinephrine, tyramine and angiotensin II, but not that of B-HT933 and vasopressin.	Tyramine	65-73	neuropeptide Y	Rattus norvegicus	0-3
2907029-5	1988	Tyramine and PEA were relatively poor substrates for SSAO, with very high apparent Km values of 17.6 and 13.3 mM, respectively, when determined in the presence of clorgyline, 10(-3) M, added to inhibit any metabolism of those amines by MAO activities.	Tyramine	0-8	amine oxidase copper containing 2	Homo sapiens	53-57
2907029-6	1988	However, kinetic studies with benzylamine indicated that clorgyline, 10(-3) M, also appears to inhibit SSAO competitively such that the true Km values for tyramine and PEA may be about 60% of those apparent values given above.	Tyramine	155-163	amine oxidase copper containing 2	Homo sapiens	103-107
2907098-0	1988	Pre- and postsynaptic effects of p-tyramine and p-octopamine in the prostatic portion of the rat vas deferens.	Tyramine	33-43	arginine vasopressin	Rattus norvegicus	97-100
2907098-3	1988	When MAO activity was inhibited by pargyline (10 mumol/l), p-tyramine and p-octopamine had mixed excitatory-inhibitory effects on the twitches, while noradrenaline had mostly excitatory effects along the whole range of concentrations assayed (0.158-15.8 mumol/l).	Tyramine	59-69	monoamine oxidase A	Rattus norvegicus	5-8
3368472-1	1988	The effect of p-tyramine, a natural amine which is found in the rat brain in trace amounts, was evaluated for its capacity to influence LH and prolactin secretion in male and female rats under different hormonal conditions.	Tyramine	14-24	prolactin	Rattus norvegicus	143-152
3368472-5	1988	On the other hand, p-tyramine inhibited prolactin secretion in male rats pretreated with EB, and not in similarly treated female rats.	Tyramine	19-29	prolactin	Rattus norvegicus	40-49
3368472-6	1988	The present results suggest that p-tyramine may be involved not only in prolactin regulation as it has been previously shown, but also in LH control, and that the hormonal response to this amine is sexually differentiated in the rat.	Tyramine	33-43	prolactin	Rattus norvegicus	72-81
2450251-6	1988	The peak concentrations of free tyramine in plasma and the concomitant increase of systolic blood pressure were significantly (p less than 0.01) smaller when tyramine was administered with a meal (before or after moclobemide) than when given with tap water.	Tyramine	32-40	nuclear RNA export factor 1	Homo sapiens	247-250
2450251-6	1988	The peak concentrations of free tyramine in plasma and the concomitant increase of systolic blood pressure were significantly (p less than 0.01) smaller when tyramine was administered with a meal (before or after moclobemide) than when given with tap water.	Tyramine	158-166	nuclear RNA export factor 1	Homo sapiens	247-250
3266532-3	1988	Brain selectivity would overcome the risk of tyramine interactions which have been shown to occur with selective MAO-A but not MAO-B inhibitors.	Tyramine	45-53	monoamine oxidase A	Homo sapiens	113-118
3171572-1	1988	The histochemical distribution of monoamine oxidase A and B in rat brain was investigated using a coupled peroxidatic technique with benzylamine and tyramine as substrates and clorgyline and (-)-deprenyl as selective inhibitors.	Tyramine	149-157	monoamine oxidase A	Rattus norvegicus	34-59
3266532-3	1988	Brain selectivity would overcome the risk of tyramine interactions which have been shown to occur with selective MAO-A but not MAO-B inhibitors.	Tyramine	45-53	monoamine oxidase B	Homo sapiens	127-132
3444478-14	1987	A larger fraction of vesicular 3H-noradrenaline is accessible to equireleasing concentrations of (+)-amphetamine (an inhibitor of MAO) than of tyramine (a substrate of MAO).	Tyramine	143-151	monoamine oxidase A	Rattus norvegicus	168-171
3595714-0	1987	Characterization of the release of neuropeptide Y (NPY) induced by tyramine from synaptosomal preparations of rabbit jejunum.	Tyramine	67-75	neuropeptide Y	Oryctolagus cuniculus	35-49
24226068-0	1987	Peroxidase-mediated integration of tyramine into xylem cell walls of tobacco leaves.	Tyramine	35-43	peroxidase N1	Nicotiana tabacum	0-10
3106018-0	1987	Prolactin inhibition by p-tyramine in the male rat: site of action.	Tyramine	24-34	prolactin	Rattus norvegicus	0-9
3106018-2	1987	In the present experiments the action of p-tyramine on PRL release in vitro, or after challenge with different hyperprolactinemic drugs (serotonin, morphine, and TRH) was tested.	Tyramine	41-51	prolactin	Rattus norvegicus	55-58
3106018-4	1987	P-Tyramine inhibited PRL release from hemipituitaries incubated in vitro at doses of 10(-4) and 10(-6) M (inhibition to 31% and 59% of control values, respectively).	Tyramine	0-10	prolactin	Rattus norvegicus	21-24
24226068-4	1987	Study of the mechanism of insolubilisation of tyramine showed that the amine was integrated in regions in which peroxidase activity could be located cytochemically using 3,3"-diaminobenzidine and H2O2 as substrates.	Tyramine	46-54	peroxidase N1	Nicotiana tabacum	112-122
2886556-3	1987	MAO was assessed by measuring the specific binding of [3H]pargyline, an irreversible MAO inhibitor, and the rates of oxidation of known MAO substrates: benzylamine, tyramine, tryptamine, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	Tyramine	165-173	monoamine oxidase A	Rattus norvegicus	0-3
3106018-6	1987	On the other hand, octopamine, which is formed from tyramine, also inhibited high PRL values found after stress, though the effective dose was higher than that of tyramine.	Tyramine	52-60	prolactin	Rattus norvegicus	82-85
3106018-6	1987	On the other hand, octopamine, which is formed from tyramine, also inhibited high PRL values found after stress, though the effective dose was higher than that of tyramine.	Tyramine	163-171	prolactin	Rattus norvegicus	82-85
3106018-8	1987	The present results indicate that tyramine can inhibit PRL release due to certain drugs, by acting directly at the pituitary level.	Tyramine	34-42	prolactin	Rattus norvegicus	55-58
3595714-5	1987	Guanethidine, however, at a concentration insufficient to block the uptake of tyramine reduced the release of both NE and NPY.	Tyramine	78-86	neuropeptide Y	Oryctolagus cuniculus	122-125
3595714-6	1987	These data suggest that tyramine enters into nerve terminals through a desipramine-sensitive mechanism, resulting in the co-release of NE and NPY which can be reduced by guanethidine.	Tyramine	24-32	neuropeptide Y	Oryctolagus cuniculus	142-145
3595714-0	1987	Characterization of the release of neuropeptide Y (NPY) induced by tyramine from synaptosomal preparations of rabbit jejunum.	Tyramine	67-75	neuropeptide Y	Oryctolagus cuniculus	51-54
3595714-1	1987	The effect of tyramine on the secretion of neuropeptide Y-like immunoreactivity (NPY-LI) was investigated in a synaptosomal fraction prepared from rabbit jejunum.	Tyramine	14-22	neuropeptide Y	Oryctolagus cuniculus	43-57
3595714-1	1987	The effect of tyramine on the secretion of neuropeptide Y-like immunoreactivity (NPY-LI) was investigated in a synaptosomal fraction prepared from rabbit jejunum.	Tyramine	14-22	neuropeptide Y	Oryctolagus cuniculus	81-84
3595714-2	1987	In addition to evoking the release of norepinephrine (NE), tyramine induced a dose-dependent increase of NPY-LI secretion which was insensitive to tetrodotoxin and was not affected by the removal of calcium ions from the bathing medium.	Tyramine	59-67	neuropeptide Y	Oryctolagus cuniculus	105-108
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-151	U2AF homology motif kinase 1	Rattus norvegicus	14-17
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-151	dopamine beta-hydroxylase	Rattus norvegicus	55-58
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-151	dopamine beta-hydroxylase	Rattus norvegicus	168-171
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-150	U2AF homology motif kinase 1	Rattus norvegicus	14-17
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-150	dopamine beta-hydroxylase	Rattus norvegicus	55-58
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Tyramine	142-150	dopamine beta-hydroxylase	Rattus norvegicus	168-171
3820219-7	1987	This correlate is used to support the hypothesis that binding of inhibitor to DBH occurs in a fashion that mimics the binding of tyramine substrates.	Tyramine	129-137	dopamine beta-hydroxylase	Rattus norvegicus	78-81
3097015-3	1986	Dopamine beta-hydroxylase activity was assessed by measuring the rate of conversion of tyramine to octopamine.	Tyramine	87-95	dopamine beta-hydroxylase	Homo sapiens	0-25
3108675-4	1987	In addition to inducing the release of 3H-norepinephrine (NE), tyramine evoked a concentration-dependent efflux of NPY-like immunoreactivity (NPY-LI) from synaptosomal preparations.	Tyramine	63-71	neuropeptide Y	Rattus norvegicus	115-118
3108675-4	1987	In addition to inducing the release of 3H-norepinephrine (NE), tyramine evoked a concentration-dependent efflux of NPY-like immunoreactivity (NPY-LI) from synaptosomal preparations.	Tyramine	63-71	neuropeptide Y	Rattus norvegicus	142-145
3108675-6	1987	Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).	Tyramine	53-61	neuropeptide Y	Rattus norvegicus	27-30
3108675-6	1987	Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).	Tyramine	53-61	neuropeptide Y	Rattus norvegicus	237-240
3108675-6	1987	Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).	Tyramine	108-116	neuropeptide Y	Rattus norvegicus	27-30
3108675-6	1987	Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).	Tyramine	108-116	neuropeptide Y	Rattus norvegicus	237-240
3108675-7	1987	Therefore, we suggest that tyramine does induce the release of NPY from rat vas deferens, in addition to effecting NE secretion.	Tyramine	27-35	neuropeptide Y	Rattus norvegicus	63-66
3796219-5	1987	Using tyramine as substrate, dopamine-beta-hydroxylase is slightly inhibited by dopamine 3-sulfate according to some irreversible or mixed mechanisms.	Tyramine	6-14	dopamine beta-hydroxylase	Homo sapiens	29-54
3031526-5	1987	Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.	Tyramine	0-8	arginine vasopressin	Rattus norvegicus	66-77
3031526-5	1987	Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.	Tyramine	0-8	arginine vasopressin	Rattus norvegicus	144-155
3108675-0	1987	Release of neuropeptide Y (NPY) induced by tyramine in the isolated vas deferens of rat.	Tyramine	43-51	neuropeptide Y	Rattus norvegicus	11-25
3108675-0	1987	Release of neuropeptide Y (NPY) induced by tyramine in the isolated vas deferens of rat.	Tyramine	43-51	neuropeptide Y	Rattus norvegicus	27-30
3108675-3	1987	In the presence of an antiserum to neuropeptide Y (NPY), the contraction induced by concentrations of tyramine greater than 10 microM was markedly increased.	Tyramine	102-110	neuropeptide Y	Rattus norvegicus	35-49
3108675-3	1987	In the presence of an antiserum to neuropeptide Y (NPY), the contraction induced by concentrations of tyramine greater than 10 microM was markedly increased.	Tyramine	102-110	neuropeptide Y	Rattus norvegicus	51-54
3480939-4	1987	Since tyramine releases noradrenaline into the cytoplasm and not by exocytosis, its action is potentiated by inhibition of neuronal MAO-A.	Tyramine	6-14	monoamine oxidase A	Homo sapiens	132-137
3822124-6	1986	The kinetics of the oxidase are similar to those of monoamine oxidase type A reported in other tissues including the adrenergic neuron, having apparent Km values of 400, 280, 170 and 227 microM for noradrenaline, dopamine, serotonin and tyramine.	Tyramine	237-245	monoamine oxidase A	Rattus norvegicus	52-76
3783606-4	1986	These inhibitors incorporate structural features that resemble both tyramine and oxygen substrates, and as evidenced by steady-state kinetics, they appear to bind both the phenethylamine binding site and the active site copper atom(s) in DBH.	Tyramine	68-76	dopamine beta-hydroxylase	Homo sapiens	238-241
2872316-5	1986	The changes in Km and Vmax values at pH 7 and pH 9 indicated that the affinities of MAO-A towards 5-HT and tyramine slightly increased at pH 9 and those of MAO-B towards tyramine and benzylamine also increased at pH 9, while uncharged amines at pH 9 amounted to about a hundred times of those at pH 7.	Tyramine	107-115	monoamine oxidase A	Rattus norvegicus	84-89
3777218-1	1986	Fetal lambs treated with sheep anti-mouse nerve growth factor antibodies (anti-NGF) at 80 days gestation subsequently showed a diminished cardiovascular response to intravenous infusion of tyramine (1 mg/min over 10 min) and no significant change in plasma norepinephrine concentrations as measured by reversed-phase high-pressure liquid chromatography and electrochemical detection.	Tyramine	189-197	beta-nerve growth factor	Ovis aries	79-82
2430159-6	1986	In vitro studies in rat brainstem mitochondrial preparations show a dose-dependent, reversible, inhibition of MAO using tyramine as the substrate for the enzyme reaction.	Tyramine	120-128	monoamine oxidase A	Rattus norvegicus	110-113
3785579-7	1986	Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine.	Tyramine	52-60	monoamine oxidase A	Rattus norvegicus	77-94
3785579-7	1986	Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine.	Tyramine	52-60	monoamine oxidase A	Rattus norvegicus	96-99
2872316-5	1986	The changes in Km and Vmax values at pH 7 and pH 9 indicated that the affinities of MAO-A towards 5-HT and tyramine slightly increased at pH 9 and those of MAO-B towards tyramine and benzylamine also increased at pH 9, while uncharged amines at pH 9 amounted to about a hundred times of those at pH 7.	Tyramine	107-115	monoamine oxidase B	Rattus norvegicus	156-161
2872316-5	1986	The changes in Km and Vmax values at pH 7 and pH 9 indicated that the affinities of MAO-A towards 5-HT and tyramine slightly increased at pH 9 and those of MAO-B towards tyramine and benzylamine also increased at pH 9, while uncharged amines at pH 9 amounted to about a hundred times of those at pH 7.	Tyramine	170-178	monoamine oxidase A	Rattus norvegicus	84-89
2872316-5	1986	The changes in Km and Vmax values at pH 7 and pH 9 indicated that the affinities of MAO-A towards 5-HT and tyramine slightly increased at pH 9 and those of MAO-B towards tyramine and benzylamine also increased at pH 9, while uncharged amines at pH 9 amounted to about a hundred times of those at pH 7.	Tyramine	170-178	monoamine oxidase B	Rattus norvegicus	156-161
3754818-0	1986	Tyramine-induced release of neuropeptide Y (NPY) in isolated rabbit intestine.	Tyramine	0-8	neuropeptide Y	Oryctolagus cuniculus	28-42
3754818-0	1986	Tyramine-induced release of neuropeptide Y (NPY) in isolated rabbit intestine.	Tyramine	0-8	neuropeptide Y	Oryctolagus cuniculus	44-47
3754818-5	1986	Thus, it is suggested that tyramine induced the release of NPY to initiate the subsequent sustained contracture.	Tyramine	27-35	neuropeptide Y	Oryctolagus cuniculus	59-62
4073489-3	1985	The method includes PLP-dependent enzymatic decarboxylation of L-tyrosine to tyramine (enzyme used: L-tyrosine apodecarboxylase (EC 4.1.1.25) from Streptococcus faecalis) and measurement of tyramine by high-performance liquid chromatography with electrochemical detection.	Tyramine	77-85	pyridoxal phosphatase	Homo sapiens	20-23
3949732-2	1986	A transmembrane electron shuttle between the external (cytosolic) and intragranular ascorbate pools was demonstrated in vitro in intact bovine chromaffin granules undergoing tyramine- or dopamine-stimulated dopamine-beta-hydroxylase turnover.	Tyramine	174-182	dopamine beta-hydroxylase	Bos taurus	207-232
3949732-4	1986	The rate of ascorbate oxidation is a function of the extragranular concentrations of tyramine over the range 50 microM to 2 mM and is 95% inhibited by addition of the dopamine-beta-hydroxylase inhibitor disulfiram.	Tyramine	85-93	dopamine beta-hydroxylase	Bos taurus	167-192
3023548-5	1986	MAO A and B were inhibited approximately equipotently and the material competitively inhibited tyramine oxidation by rat liver.	Tyramine	95-103	monoamine oxidase A	Rattus norvegicus	0-11
3534860-7	1986	The following sympathetic components may contribute to the effect of angiotensin II:ganglionic stimulation; enhanced release of noradrenaline (tyramine-like effect); inhibited noradrenaline re-uptake; facilitation of noradrenaline release via presynaptic AII-receptors; sensitization of postsynaptic alpha-adrenoceptors.	Tyramine	143-151	angiotensinogen	Homo sapiens	69-83
3953019-1	1986	Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR).	Tyramine	112-120	monoamine oxidase A	Rattus norvegicus	12-30
3953019-1	1986	Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR).	Tyramine	112-120	monoamine oxidase A	Rattus norvegicus	32-35
3953019-4	1986	However, in experiments with tyramine as a substrate of MAO the enzymatic activity in SHR brain mitochondria was increased 1.5-fold (P less than 0.05) as compared with the WKY rats.	Tyramine	29-37	monoamine oxidase A	Rattus norvegicus	56-59
3953019-5	1986	In kidney mitochondria of SHR the activity of MAO (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) did not exhibit any alterations as compared with the control WKY rats.	Tyramine	104-112	monoamine oxidase A	Rattus norvegicus	46-49
3083168-5	1986	This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO).	Tyramine	21-29	monoamine oxidase A	Rattus norvegicus	140-157
3083168-5	1986	This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO).	Tyramine	21-29	monoamine oxidase A	Rattus norvegicus	159-162
3840523-8	1985	Such combinations had a greatly reduced propensity to augment the cardiovascular effects of intraduodenally administered tyramine, when compared with FMMT given alone or with clorgyline, a selective inhibitor of MAO type A.	Tyramine	121-129	monoamine oxidase A	Rattus norvegicus	212-215
3840523-9	1985	The results obtained with FMMT suggest the possibility of achieving selective inhibition of MAO within monoamine nerves of the CNS and, further, suggest that combination of FMMT with an inhibitor of extracerebral AADC will reduce the propensity of this inhibitor to produce adverse interactions with tyramine.	Tyramine	300-308	dopa decarboxylase	Rattus norvegicus	213-217
4073489-3	1985	The method includes PLP-dependent enzymatic decarboxylation of L-tyrosine to tyramine (enzyme used: L-tyrosine apodecarboxylase (EC 4.1.1.25) from Streptococcus faecalis) and measurement of tyramine by high-performance liquid chromatography with electrochemical detection.	Tyramine	190-198	pyridoxal phosphatase	Homo sapiens	20-23
3987630-0	1985	p-Tyramine, a natural amine, inhibits prolactin release in vivo.	Tyramine	0-10	prolactin	Rattus norvegicus	38-47
3928010-4	1985	The pressor responses to tyramine were potentiated by the selective MAO-A inhibitor clorgyline (2 mg kg-1) but not by selegiline (1.0 mg kg-1) and AGN 1135 (1.5 mg kg-1), selective MAO-B inhibitors.	Tyramine	25-33	monoamine oxidase A	Homo sapiens	68-73
3928010-4	1985	The pressor responses to tyramine were potentiated by the selective MAO-A inhibitor clorgyline (2 mg kg-1) but not by selegiline (1.0 mg kg-1) and AGN 1135 (1.5 mg kg-1), selective MAO-B inhibitors.	Tyramine	25-33	monoamine oxidase B	Homo sapiens	181-186
3987630-6	1985	These results show that low amounts of tyramine, a naturally occurring amine, can inhibit in vivo increases in PRL levels achieved physiologically or pharmacologically.	Tyramine	39-47	prolactin	Rattus norvegicus	111-114
4073474-2	1985	Results indicated an underestimation of MAO activity when liquid ion exchange chromatography (LIEC) was used instead of an ion exchange chromatographic method (IEC) to separate the different products of the deaminated tyramine, phenylethylamine, or serotonin.	Tyramine	218-226	monoamine oxidase A	Rattus norvegicus	40-43
3987630-2	1985	When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress.	Tyramine	18-28	prolactin	Rattus norvegicus	43-46
3987630-4	1985	When PRL levels were increased by pretreatment with alpha-methyl-p-tyrosine or haloperidol, once again both tyramine and dopamine lowered PRL titers.	Tyramine	108-116	prolactin	Rattus norvegicus	5-8
3987630-4	1985	When PRL levels were increased by pretreatment with alpha-methyl-p-tyrosine or haloperidol, once again both tyramine and dopamine lowered PRL titers.	Tyramine	108-116	prolactin	Rattus norvegicus	138-141
3839173-8	1985	Pargyline and tranylcypromine shifted the dose-response curves for tyramine and beta-phenylethylamine, but not serotonin, to the left, indicating inhibition of type B MAO.	Tyramine	67-75	monoamine oxidase A	Rattus norvegicus	167-170
3972830-9	1985	Purified bovine-soluble dopamine beta-hydroxylase activity is a hyperbolic function of tyramine concentration at pH 5.0.	Tyramine	87-95	dopamine beta-hydroxylase	Bos taurus	24-49
3835805-1	1985	In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates.	Tyramine	163-171	monoamine oxidase A	Rattus norvegicus	152-155
3835805-2	1985	It was established that ZnSO4 significantly increased the activity of liver MAO with all substrates studied, Co(NO3)2 increased it when tyramine and serotonin were used while NiSO4 increased MAO activity when serotonin was used as a substrate.	Tyramine	136-144	monoamine oxidase A	Rattus norvegicus	76-79
3929314-5	1985	Reductions in plasma 3-methoxy,4-hydroxyphenylglycol (MHPG), used as a possible index of in vivo MAO-A inhibition, were highly correlated with increases in tyramine pressor sensitivity (r = 0.82).	Tyramine	156-164	monoamine oxidase A	Homo sapiens	97-102
6712358-4	1984	Doubling the concentration of glucose in the solution bathing the isolated vas deferens from rats fasted for 24 hr increased the responses to noradrenaline and tyramine.	Tyramine	160-168	arginine vasopressin	Rattus norvegicus	75-78
6748374-3	1984	The selective and potent MAO-A and MAO-B inhibitors FLA 788(+), FLA 336(+), MD 780236 and benzylcyanide caused dose-dependent inhibitions of MAO activity in both carp brain and liver; the inhibition curves were all single-sigmoidal, and the degrees of inhibition of the activities towards 5-hydroxytryptamine (5-HT, selective MAO-A substrate), tyramine (substrate for both forms of MAO) and beta-phenylethylamine (PEA, selective MAO-B substrate) were similar.	Tyramine	344-352	monoamine oxidase B	Rattus norvegicus	35-40
6748816-3	1984	produces a slight but appreciable inhibition of MAO activity with tyramine or serotonin but not with benzylamine as substrate in both rat brain and liver mitochondria.	Tyramine	66-74	monoamine oxidase A	Rattus norvegicus	48-51
6748816-4	1984	Lignocaine (2-20 mM) inhibits (in vitro) both brain and liver mitochondrial MAO activity, using tyramine, serotonin and benzylamine as substrates, in a concentration-dependent manner.	Tyramine	96-104	monoamine oxidase A	Rattus norvegicus	76-79
6748816-5	1984	Furthermore, lignocaine produces a marked in vitro inhibition of serotonin and tyramine oxidation in MAO-A and not in MAO-B preparation of rat brain.	Tyramine	79-87	monoamine oxidase A	Rattus norvegicus	101-106
6748816-7	1984	Lineweaver-Burk plots show that lignocaine (2-10 mM) produces a significant increase in Km and decrease in Vmax of MAO for tyramine and serotonin in both brain and liver.	Tyramine	123-131	monoamine oxidase A	Rattus norvegicus	115-118
6319404-10	1984	Tyramine stabilized [14C]cyanide binding to dopamine beta-hydroxylase, consistent with the lack of enzyme reactivation observed under certain conditions (Colombo, G., Giedroc, D. P., Rajashekhar, B., and Villafranca, J. J.	Tyramine	0-8	dopamine beta-hydroxylase	Homo sapiens	44-69
6319404-14	1984	EPR data for dopamine beta-hydroxylase-bound Cu2+ directly demonstrated that a quaternary complex with tyramine and cyanide was formed, since the spectrum of dopamine beta-hydroxylase-Cu2+-tyramine-cyanide is distinct from that of dopamine beta-hydroxylase-Cu2+-cyanide and dopamine beta-hydroxylase-Cu2+-tyramine.	Tyramine	103-111	dopamine beta-hydroxylase	Homo sapiens	13-38
6319404-14	1984	EPR data for dopamine beta-hydroxylase-bound Cu2+ directly demonstrated that a quaternary complex with tyramine and cyanide was formed, since the spectrum of dopamine beta-hydroxylase-Cu2+-tyramine-cyanide is distinct from that of dopamine beta-hydroxylase-Cu2+-cyanide and dopamine beta-hydroxylase-Cu2+-tyramine.	Tyramine	103-111	dopamine beta-hydroxylase	Homo sapiens	158-183
6319404-14	1984	EPR data for dopamine beta-hydroxylase-bound Cu2+ directly demonstrated that a quaternary complex with tyramine and cyanide was formed, since the spectrum of dopamine beta-hydroxylase-Cu2+-tyramine-cyanide is distinct from that of dopamine beta-hydroxylase-Cu2+-cyanide and dopamine beta-hydroxylase-Cu2+-tyramine.	Tyramine	103-111	dopamine beta-hydroxylase	Homo sapiens	158-183
6319404-14	1984	EPR data for dopamine beta-hydroxylase-bound Cu2+ directly demonstrated that a quaternary complex with tyramine and cyanide was formed, since the spectrum of dopamine beta-hydroxylase-Cu2+-tyramine-cyanide is distinct from that of dopamine beta-hydroxylase-Cu2+-cyanide and dopamine beta-hydroxylase-Cu2+-tyramine.	Tyramine	103-111	dopamine beta-hydroxylase	Homo sapiens	158-183
6099973-4	1984	Also both noradrenaline and tyramine were more effective on the infected vas deferens suggesting a post-junctional sensitization of alpha adrenoceptors.	Tyramine	28-36	arginine vasopressin	Rattus norvegicus	73-76
6741571-3	1984	The increase in MAO activity in the presence of human plasma can be explained by the observed decrease in the apparent Km for the amine (tyramine, PEA).	Tyramine	137-145	monoamine oxidase A	Rattus norvegicus	16-19
6117620-5	1981	In addition, plasma DBH activities following sympathetic outflow stimulation and tyramine administration were markedly increased and decreased respectively compared with untreated controls.	Tyramine	81-89	dopamine beta-hydroxylase	Rattus norvegicus	20-23
6627826-9	1983	This may reflect the dose of cimoxatone used, the activity of monoamine oxidase form B (MAO-B) in the gut and liver or displacement of the predominantly reversible and predominantly competitive inhibitor, cimoxatone, from the enzyme by a high local tyramine concentration.	Tyramine	249-257	monoamine oxidase B	Homo sapiens	88-93
6122719-4	1982	Tyramine, norepinephrine, and epinephrine also stimulate the cyclase, probably via the octopamine receptor.	Tyramine	0-8	Octopamine-Tyramine receptor	Drosophila melanogaster	87-106
7080482-1	1982	Monoamine oxidase (MAO) activity (substrate: tyramine) has been studied in rat intestinal wall mitochondrial fractions identified by monitoring succinate dehydrogenase and cytochrome oxidase activities.	Tyramine	45-53	monoamine oxidase A	Rattus norvegicus	0-17
7080482-1	1982	Monoamine oxidase (MAO) activity (substrate: tyramine) has been studied in rat intestinal wall mitochondrial fractions identified by monitoring succinate dehydrogenase and cytochrome oxidase activities.	Tyramine	45-53	monoamine oxidase A	Rattus norvegicus	19-22
7074998-4	1982	Dopamine-beta-hydroxylase (DBH) was assayed by a sensitive radioenzymatic assay using tyramine as the substrate.	Tyramine	86-94	dopamine beta-hydroxylase	Rattus norvegicus	0-25
7074998-4	1982	Dopamine-beta-hydroxylase (DBH) was assayed by a sensitive radioenzymatic assay using tyramine as the substrate.	Tyramine	86-94	dopamine beta-hydroxylase	Rattus norvegicus	27-30
6797482-3	1981	After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased.	Tyramine	141-149	monoamine oxidase A	Rattus norvegicus	24-27
6797482-3	1981	After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased.	Tyramine	141-149	monoamine oxidase A	Rattus norvegicus	187-190
6645113-7	1983	Km values for tyramine of heart MAO in WKY and SHR were approx.	Tyramine	14-22	monoamine oxidase A	Rattus norvegicus	32-35
6414536-5	1983	In intact mitochondria the intensity of inhibition by clorgyline of tyramine deamination in the presence of benzyl alcohol (competitive reversible MAO inhibitor) was increased, but the additive effect was not achieved.	Tyramine	68-76	monoamine oxidase A	Rattus norvegicus	147-150
6131537-3	1983	Thus, spinal AADC neurons have the enzymatic capacity to catalyze directly the conversion of the amino acids tyrosine, tryptophan, or phenylalanine to their respective amines tyramine, tryptamine, or phenylethylamine.	Tyramine	175-183	dopa decarboxylase	Rattus norvegicus	13-17
6830619-0	1983	Intestinal metabolism of tyramine by both forms of monoamine oxidase in the rat.	Tyramine	25-33	monoamine oxidase A	Rattus norvegicus	51-68
6830619-1	1983	The two forms of monoamine oxidase (MAO) in rat intestine and brain homogenates were found to have different Km and Vmax values towards tyramine.	Tyramine	136-144	monoamine oxidase A	Rattus norvegicus	17-34
6830619-1	1983	The two forms of monoamine oxidase (MAO) in rat intestine and brain homogenates were found to have different Km and Vmax values towards tyramine.	Tyramine	136-144	monoamine oxidase A	Rattus norvegicus	36-39
6830619-3	1983	As a consequence, the ratio of activities (MAO-A: MAO-B) towards tyramine are dependent upon the substrate concentration.	Tyramine	65-73	monoamine oxidase A	Rattus norvegicus	43-48
6830619-3	1983	As a consequence, the ratio of activities (MAO-A: MAO-B) towards tyramine are dependent upon the substrate concentration.	Tyramine	65-73	monoamine oxidase B	Rattus norvegicus	50-55
6830619-4	1983	The MAO-A-selective inhibitors, toloxatone and cimoxatone, were found to be competitive inhibitors of the oxidation of tyramine by the A-form of this enzyme in the rat intestine, with Ki values of 3.4 microM and 3.7 nM respectively.	Tyramine	119-127	monoamine oxidase A	Rattus norvegicus	4-9
6830619-5	1983	The significance of these results in relation to the "cheese effect", a pressor response to tyramine after monoamine oxidase inhibition, are discussed.	Tyramine	92-100	monoamine oxidase A	Rattus norvegicus	107-124
6686709-0	1983	Levels of p-tyramine in rat brain after chronic administration of MAO-inhibiting antidepressants.	Tyramine	10-20	monoamine oxidase A	Rattus norvegicus	66-69
6127132-6	1982	5 Potentiation of tyramine responses by clorgyline and LY51641 occurred at 91% and 64% inhibition of MAO type A respectively, although full potentiation of the tyramine response was elicited only when substantial inhibition of both enzyme types occurred.	Tyramine	18-26	monoamine oxidase A	Rattus norvegicus	101-104
6180024-1	1982	Use of 125iodinated progesterone 11 alpha-glucuronide-tyramine conjugate as radioligand with the majority of antisera raised against progesterone 11 alpha-hemisuccinate-bovine serum albumin is shown to produce steep and sensitive standard curves.	Tyramine	54-62	albumin	Homo sapiens	176-189
6784775-4	1981	This intermediate was reacted with ammonia, histamine, tyramine or N alpha-acetyl-lysine methyl ester (N alpha Ac-Lys-OMe) to yield the respective unsubstituted and N-substituted Nim-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH2, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N alpha Ac-Lys-OMe.	Tyramine	55-63	thyrotropin releasing hormone	Oryctolagus cuniculus	210-213
6793119-0	1981	Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B.	Tyramine	0-8	monoamine oxidase B	Rattus norvegicus	75-99
6784775-4	1981	This intermediate was reacted with ammonia, histamine, tyramine or N alpha-acetyl-lysine methyl ester (N alpha Ac-Lys-OMe) to yield the respective unsubstituted and N-substituted Nim-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH2, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N alpha Ac-Lys-OMe.	Tyramine	55-63	thyrotropin releasing hormone	Oryctolagus cuniculus	227-230
6784775-4	1981	This intermediate was reacted with ammonia, histamine, tyramine or N alpha-acetyl-lysine methyl ester (N alpha Ac-Lys-OMe) to yield the respective unsubstituted and N-substituted Nim-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH2, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N alpha Ac-Lys-OMe.	Tyramine	55-63	thyrotropin releasing hormone	Oryctolagus cuniculus	227-230
6784775-4	1981	This intermediate was reacted with ammonia, histamine, tyramine or N alpha-acetyl-lysine methyl ester (N alpha Ac-Lys-OMe) to yield the respective unsubstituted and N-substituted Nim-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH2, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N alpha Ac-Lys-OMe.	Tyramine	55-63	thyrotropin releasing hormone	Oryctolagus cuniculus	227-230
6784775-4	1981	This intermediate was reacted with ammonia, histamine, tyramine or N alpha-acetyl-lysine methyl ester (N alpha Ac-Lys-OMe) to yield the respective unsubstituted and N-substituted Nim-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH2, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N alpha Ac-Lys-OMe.	Tyramine	55-63	thyrotropin releasing hormone	Oryctolagus cuniculus	227-230
7248043-4	1981	The ratio of V of serum DBH (tyramine as substrate) tended to be lower in patients independent of their psychopathological state than in controls.	Tyramine	29-37	dopamine beta-hydroxylase	Homo sapiens	24-27
6455104-1	1981	The MAO activity (tyramine substrate) was measured in 17 different brain regions, the spinal cord, and 13 different organs of four patients with Huntington"s disease and three patients with Parkinson"s disease.	Tyramine	18-26	monoamine oxidase A	Rattus norvegicus	4-7
6245422-6	1980	Both TyA-induced and 5-HT-induced head-twitches were inhibited by dopamine and noradrenaline, while catecholaminergic denervators such as reserpine and 6-hydroxydopamine, and diethyldithiocarbamic acid, a dopamine-beta-hydroxylase inhibitor, increased the TyA response.	Tyramine	5-8	dopamine beta hydroxylase	Mus musculus	205-230
6791202-4	1981	The effects of treatment with the selective MAO-A inhibitor clorgyline and the partially selective MAO-B inhibitors pargyline and deprenyl on tyramine"s pressor effects were studied in depressed patients using an IV steady-state tyramine infusion technique.	Tyramine	142-150	monoamine oxidase B	Homo sapiens	99-104
6791210-7	1981	Tyramine pressor sensitivity changes accompanying administration of the MAO inhibitors were highly correlated with decreases in plasma MHPG (r = 0.92), supporting our previous data indicating the rank order of clorgyline greater than pargyline greater than deprenyl for enhancement of tyramine pressor sensitivity and, thus, suggesting that tyramine potentiation is primarily a function of MAO-A rather than MAO-B inhibition.	Tyramine	0-8	monoamine oxidase A	Homo sapiens	390-395
6791210-7	1981	Tyramine pressor sensitivity changes accompanying administration of the MAO inhibitors were highly correlated with decreases in plasma MHPG (r = 0.92), supporting our previous data indicating the rank order of clorgyline greater than pargyline greater than deprenyl for enhancement of tyramine pressor sensitivity and, thus, suggesting that tyramine potentiation is primarily a function of MAO-A rather than MAO-B inhibition.	Tyramine	0-8	monoamine oxidase B	Homo sapiens	408-413
6786369-0	1980	[Mechanism of inhibition by chlorgyline and deprenyl of tyramine deamination by mitochondrial monoamine oxidase of rat liver].	Tyramine	56-64	monoamine oxidase A	Rattus norvegicus	94-111
6786369-1	1980	The inhibition by chlorgyline and deprenyl of deamination of tyramine, i. e. substrate of two forms of monoamine oxidase (MAO) A and B, by fragments of rat liver mitochondrial membrane and the effects of competitive reversible inhibitors of the MAO activity, e. g. 4-ethylpyridine, benzyl alcohol, O-benzyl-hydroxylamine and 2-oxyquinoline, on this process were studied.	Tyramine	61-69	monoamine oxidase A	Rattus norvegicus	103-134
6786369-1	1980	The inhibition by chlorgyline and deprenyl of deamination of tyramine, i. e. substrate of two forms of monoamine oxidase (MAO) A and B, by fragments of rat liver mitochondrial membrane and the effects of competitive reversible inhibitors of the MAO activity, e. g. 4-ethylpyridine, benzyl alcohol, O-benzyl-hydroxylamine and 2-oxyquinoline, on this process were studied.	Tyramine	61-69	monoamine oxidase A	Rattus norvegicus	122-125
6786369-3	1980	The stimulating effect is due to the independent action of two inhibitors on the two different sites of the MAO active center: chlorgyline--on the isoalloxazine ring of FAD, that of 4-ethylpyridine, benzyl alcohol, O-benzylhydroxylamine, 2-oxyquinoline, respectively, on the hydrophobic region involved in tyramine binding.	Tyramine	306-314	monoamine oxidase A	Rattus norvegicus	108-111
6786369-6	1980	The data obtained revealed the differences in the type and mechanism of action of chlorgyline and deprenyl on tyramine deamination and showed that these inhibitors act on different sites of the MAO active center, responsible for tyramine oxidation.	Tyramine	110-118	monoamine oxidase A	Rattus norvegicus	194-197
6786369-6	1980	The data obtained revealed the differences in the type and mechanism of action of chlorgyline and deprenyl on tyramine deamination and showed that these inhibitors act on different sites of the MAO active center, responsible for tyramine oxidation.	Tyramine	229-237	monoamine oxidase A	Rattus norvegicus	194-197
7421140-5	1980	This derivative was prepared by coupling 4-hemisuccinamidobiphenyl (4-HSBP) with tyramine, and then radioiodinating this compound using the enzymatic lactoperoxidase method.	Tyramine	81-89	selenium binding protein 1	Homo sapiens	70-74
41907-1	1979	The specific actiivty of rat heart MAO, towards both tyramine and benzylamine as substrates, was found to increase with the age of the animal, and also after administration of (-)-thyroxine to young male rats.	Tyramine	53-61	monoamine oxidase A	Rattus norvegicus	35-38
41907-4	1979	Clorgyline and deprenyl, used as inhibitors of rat heart MAO, indicated that tyramine is metabolized solely by MAO-A, whereas benzylamine is a substrate for both MAO-A and -B, and also a clorgyline- and deprenyl-resistant enzymic activity.	Tyramine	77-85	monoamine oxidase A	Rattus norvegicus	57-60
41907-4	1979	Clorgyline and deprenyl, used as inhibitors of rat heart MAO, indicated that tyramine is metabolized solely by MAO-A, whereas benzylamine is a substrate for both MAO-A and -B, and also a clorgyline- and deprenyl-resistant enzymic activity.	Tyramine	77-85	monoamine oxidase A	Rattus norvegicus	111-116
21237-3	1977	The remainder of the tyramine deamination is brought about by MAO-A and MAO-B.	Tyramine	21-29	monoamine oxidase A	Gallus gallus	62-67
109783-4	1979	The inhibition of tyramine deamination by clorgyline and deprenyl yielded biphasic plots indicative of the presence of MAO-A and MAO-B enzyme forms in the vervet brain.	Tyramine	18-26	monoamine oxidase A	Rattus norvegicus	119-124
478387-4	1979	The tyramine level was remarkably high one hour after insulin injection.	Tyramine	4-12	insulin	Homo sapiens	54-61
363735-2	1978	The method, which is based on the separation on a microparticulate bonded strong cation-exchange resin and measurement of the native fluorescence, has been applied to give a sensitive assay of dopamine beta-monooxygenase (EC 1.14.17.1) activity in human serum with tyramine as the substrate.	Tyramine	265-273	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	222-226
393420-0	1979	Fluorescence enzyme immunoassay for insulin using peroxidase-tyramine-hydrogen peroxide.	Tyramine	61-69	insulin	Homo sapiens	36-43
222733-0	1979	Arylsulfatase in Salmonella typhimurium: detection and influence of carbon source and tyramine on its synthesis.	Tyramine	86-94	putative arylsulfatase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	0-13
475507-5	1979	Reserpine pretreatment diminished the response of the vas to tyramine; however, methyldopa restored the responses to a greater magnitude suggesting the formation of methyldopamine and methylnoradrenaline.	Tyramine	61-69	arginine vasopressin	Rattus norvegicus	54-57
446597-0	1979	Effects of thyroidectomy on monoamine oxidase activities toward tyramine and serotonin in the circumventricular nuclei of the rat.	Tyramine	64-72	monoamine oxidase A	Rattus norvegicus	28-45
446597-1	1979	Following thyroidectomy, monoamine oxidase (MAO) activities toward tyramine decreased significantly by 20% in the nucleus periventricularis and the nucleus arcuatus among the 3 hypothalamic nuclei of the rat, while MAO activity toward serotonin decreased significantly by 10% only in the nucleus periventricularis.	Tyramine	67-75	monoamine oxidase A	Rattus norvegicus	25-42
446597-1	1979	Following thyroidectomy, monoamine oxidase (MAO) activities toward tyramine decreased significantly by 20% in the nucleus periventricularis and the nucleus arcuatus among the 3 hypothalamic nuclei of the rat, while MAO activity toward serotonin decreased significantly by 10% only in the nucleus periventricularis.	Tyramine	67-75	monoamine oxidase A	Rattus norvegicus	44-47
429200-1	1979	Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates.	Tyramine	183-191	monoamine oxidase A	Rattus norvegicus	0-17
429200-1	1979	Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates.	Tyramine	183-191	monoamine oxidase A	Rattus norvegicus	19-22
555128-1	1979	Dopamine, noradrenaline, tyramine, amantadine and apomorphine produced concentration-related contractions of the rat vas deferens "in vitro".	Tyramine	25-33	arginine vasopressin	Rattus norvegicus	117-120
673021-0	1978	Inhibitory effect of tyramine-induced release of catecholamines on renin secretion.	Tyramine	21-29	renin	Rattus norvegicus	67-72
673021-1	1978	The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats.	Tyramine	49-57	renin	Rattus norvegicus	105-110
673021-2	1978	Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration.	Tyramine	0-8	renin	Rattus norvegicus	90-95
673021-4	1978	Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release.	Tyramine	110-118	renin	Rattus norvegicus	122-127
673021-4	1978	Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release.	Tyramine	110-118	renin	Rattus norvegicus	209-214
21237-3	1977	The remainder of the tyramine deamination is brought about by MAO-A and MAO-B.	Tyramine	21-29	monoamine oxidase B	Gallus gallus	72-77
21126-2	1977	MAO activity in rat brain mitochondria with tyramine as substrate at 100% oxygen concentration was three times as much as that at 20%.	Tyramine	44-52	monoamine oxidase A	Rattus norvegicus	0-3
919375-1	1977	Inhibition of monoamine oxidase (substrates tyramine or serotonin) with simultaneous appearance of diamine oxidase (substrates histamine or putrescine) and distinct increase in AMP-deaminating activities were found after total body X-ray irradiation (700 r) of white mice or rats in mitochondrial fractions isolated from their liver and intestines.	Tyramine	44-52	amine oxidase, copper-containing 1	Mus musculus	99-114
14872-7	1976	In isolated rat vas deferens pretreated with CD-3400 for 1, 2 and 5 days,, the contraction induced by tyramine (3 X 10(-5)M) was significantly inhibited.	Tyramine	102-110	arginine vasopressin	Rattus norvegicus	16-19
831826-8	1977	The phenolic amines, octopamine, synephrine, serotonin and tyramine, stimulated tRNA methylation slightly while inhibiting histone methylation by both liver and brain extracts and these effects showed no age dependency.	Tyramine	59-67	Trng	Rattus norvegicus	80-84
831826-8	1977	The phenolic amines, octopamine, synephrine, serotonin and tyramine, stimulated tRNA methylation slightly while inhibiting histone methylation by both liver and brain extracts and these effects showed no age dependency.	Tyramine	59-67	H2B clustered histone 1	Rattus norvegicus	123-130
21126-5	1977	At 100% oxygen concentration, pargyline showed the most potent inhibition of MAO activity in liver mitochondria with tyramine as substrate, but inhibitions caused by pheniprazine and harmaline were not remarkable.	Tyramine	117-125	monoamine oxidase A	Rattus norvegicus	77-80
319927-0	1977	Tyramine interference in assay of serum dopamine-beta-hydroxylase.	Tyramine	0-8	dopamine beta-hydroxylase	Homo sapiens	40-65
12389-3	1976	Enzymic properties of partially purified monoamine oxidase (MAO) from human placenta were studied with tyramine, serotonin and benzylamine as substrates.	Tyramine	103-111	monoamine oxidase A	Rattus norvegicus	60-63
938792-8	1976	6 Studies on rat isolated vas deferens again showed that responses to tyramine are greatly reduced following fenfluramine.	Tyramine	70-78	arginine vasopressin	Rattus norvegicus	26-29
10424-2	1976	The levels of tyramine in brain were increased to a similar extent by injecting animals with a monoamine oxidase inhibitor, pargyline, and a dopamine beta-hydroxylase inhibitor, FLA-63; in contrast, pretreatment of animals with alpha-methyl-para-tyrosine, a tyrosine hydroxylase inhibitor, did not lead to an increase in tyramine levels in brain.	Tyramine	14-22	dopamine beta-hydroxylase	Rattus norvegicus	141-166
938797-6	1976	3 MAO activity towards kynuramine, tyramine and dopamine increased after birth in all brain regions and also in the liver, to reach maximal values between days 40 and 80.	Tyramine	35-43	monoamine oxidase A	Rattus norvegicus	2-5
938797-19	1976	7 In the domestic pig there was a significant rise in the values in hippocampal MAO activity towards dopamine and tyramine from the foetus (55 day gestation) to the 1 week old piglet.	Tyramine	114-122	monoamine oxidase A	Rattus norvegicus	80-83
33892344-3	2021	In the range of mug/L, exposure to nanopolystyrene (100 nm) increased the expression of tdc-1 encoding a tyrosine decarboxylase required for synthesis of tyramine, and decreased the expression of eat-4 encoding a glutamate transporter.	Tyramine	154-162	Tyrosine decarboxylase	Caenorhabditis elegans	88-93
936210-7	1976	(e) Both inhibitions of cysteine on dopamine-beta-hydroxylase with and without pretreatment were the noncompetitive type to the substrate, tyramine.	Tyramine	139-147	dopamine beta-hydroxylase	Homo sapiens	36-61
1262860-3	1976	When the activity of MAO was plotted as % of the highest specific activity towards tyramine, kynuramine oxidation remained fairly constant in fractions 10 to 30 but tyramine and dopamine showed separate peaks of activity in fractions 21 and 32 respectively.	Tyramine	83-91	monoamine oxidase A	Rattus norvegicus	21-24
1262860-3	1976	When the activity of MAO was plotted as % of the highest specific activity towards tyramine, kynuramine oxidation remained fairly constant in fractions 10 to 30 but tyramine and dopamine showed separate peaks of activity in fractions 21 and 32 respectively.	Tyramine	165-173	monoamine oxidase A	Rattus norvegicus	21-24
1221134-5	1975	Dopamine beta-hydroxylase (DBH) activity, using tyramine as substrate, in heart, aorta, mesenteric artery and renal artery was markedly reduced.	Tyramine	48-56	dopamine beta-hydroxylase	Rattus norvegicus	0-25
1221134-5	1975	Dopamine beta-hydroxylase (DBH) activity, using tyramine as substrate, in heart, aorta, mesenteric artery and renal artery was markedly reduced.	Tyramine	48-56	dopamine beta-hydroxylase	Rattus norvegicus	27-30
242128-1	1975	A method for the estimation of dopamine beta-hydroxylase activity in human serum is described, based on a thin layer chromatographic separation of the substrate ([14C]tyramine) from the reaction product ([14C]octopamine).	Tyramine	167-175	dopamine beta-hydroxylase	Homo sapiens	31-56
4455332-2	1974	Tyramine caused contraction in 10 out of 18 guinea-pig vas deferens; EA caused contraction in 17 of the preparations which did not respond to tyramine.	Tyramine	0-8	arginine vasopressin	Rattus norvegicus	55-58
5400117-0	1969	[Reduction of the vasopressor effect of tyramine in patients with hypertension, aldosteronism and low plasma renin].	Tyramine	40-48	renin	Homo sapiens	109-114
13798429-3	1960	The responses of the nictitating membrane to adrenaline, noradrenaline and tyramine were potentiated by substance P as well.	Tyramine	75-83	tachykinin precursor 1	Homo sapiens	104-115
33892344-6	2021	In the neurons, TYRA-2 functioned as the corresponding receptor of tyramine and acted upstream of MPK-1 signaling to regulate the nanopolystyrene toxicity.	Tyramine	67-75	Tyramine receptor tyra-2	Caenorhabditis elegans	16-22
1155-2	1976	We used this system to study effects of tyramine (an indirectly acting amine capable of displacing endogenous catecholmines from sympathetic nerve endings) on renin release.	Tyramine	40-48	renin	Rattus norvegicus	159-164
1155-3	1976	Tyramine (10(-3)M) in the presence of a monoamine oxidase inhibitor (pheniprazine, 10(-5)M) and a phosphodiesterase inhibitor (theophylline, 10(-3)M) significantly (P less than 0.01) stimulated renin release when values were compared to control observations for media containing only the inhibitors.	Tyramine	0-8	renin	Rattus norvegicus	194-199
1155-4	1976	Tyramine-induced stimulation of renin release was blocked by the beta-blocking agent, propranolol (2 X 10(-4) M), and the neural uptake blocking agent, cocaine (10(-5) M), but not by the alpha-antagonist, phentolamine (9 X 10(-4) M).	Tyramine	0-8	renin	Rattus norvegicus	32-37
988114-3	1976	The mean values for the eleven volunteers were: DBH 65.8+/-25.8 nanomoles hydroxylated tyramine per ml serum and hour (At substrate concentration 0.05 mM), HVA 89.9+/-57.3 ng/ml serum and MHPG 10.9+/-3.4 ng/ml, with variation coefficient of 38.6, 63.8 and 30.1 respectively.	Tyramine	87-95	dopamine beta-hydroxylase	Homo sapiens	48-51
1080179-1	1975	The monoamine oxidase (MAO) activity in the ovariectomized rat uterus was significantly increased above control levels in animals given testosterone: 33% (P smaller than 0.01) with tryptamine or 34% (P smaller than 0.05) with tyramine as substrate.	Tyramine	226-234	monoamine oxidase A	Rattus norvegicus	4-21
1080179-1	1975	The monoamine oxidase (MAO) activity in the ovariectomized rat uterus was significantly increased above control levels in animals given testosterone: 33% (P smaller than 0.01) with tryptamine or 34% (P smaller than 0.05) with tyramine as substrate.	Tyramine	226-234	monoamine oxidase A	Rattus norvegicus	23-26
1080179-3	1975	Progesterone injection increased MAO activity toward tyramine by 20% but towards tryptamine by only 8%.	Tyramine	53-61	monoamine oxidase A	Rattus norvegicus	33-36
1171051-8	1975	Interaction between tyramine and clonidine was also seen in vitro, but it disappeared in the reserpinized, denervated or propranolol-pretreated guinea-pig vas deferens.	Tyramine	20-28	arginine vasopressin	Rattus norvegicus	155-158
4796394-2	1973	Stereoselective labelling at C-2 of tyramine: stereochemistry of hydroxylation at saturated carbon.	Tyramine	36-44	complement C2	Homo sapiens	29-32
5768130-0	1969	The effect of cocaine and imipramine on tyramine-induced release of noradrenaline-3H from the rat vas deferens in vitro.	Tyramine	40-48	arginine vasopressin	Rattus norvegicus	98-101
5768130-2	1969	Tyramine 10(-4)M significantly increased release of noradrenaline-7-(3)H (NA-7-(3)H) from rat vas deferens in vitro.2.	Tyramine	0-8	arginine vasopressin	Rattus norvegicus	94-97
5768130-6	1969	It is suggested that the tyramine receptor in rat vas deferens differs from that in other systems and that blockade of tyramine-released noradrenaline at alpha-adrenergic receptors may be the most important mechanism for tyramine antagonism by imipramine-like drugs in this tissue.	Tyramine	25-33	arginine vasopressin	Rattus norvegicus	50-53
19871095-6	1941	Tyrosinase inactivates renin, angiotonin, Victor"s pressor substance, adrenalin, and tyramine in vitro, and alters the response of the blood pressure to these substances in rats and dogs.	Tyramine	85-93	tyrosinase	Rattus norvegicus	0-10
33984269-3	2021	Here, we show that in C. elegans, loss of neuronal fzo-1/mitofusin induces nonautonomous UPRmt through multiple neurotransmitters and neurohormones, including acetylcholine, serotonin, glutamate, tyramine, and insulin-like peptides.	Tyramine	196-204	Transmembrane GTPase fzo-1	Caenorhabditis elegans	51-56
33992221-4	2021	Previously, these Q-TAO strips have been also optimized for tyramine determination in cheese extract.	Tyramine	60-68	monoamine oxidase B	Homo sapiens	20-23
33998627-0	2021	Modulation of inflammation by anti-TNF alpha mAb-dendrimer nanoparticles loaded in tyramine-modified gellan gum hydrogels in a cartilage-on-a-chip model.	Tyramine	83-91	tumor necrosis factor	Homo sapiens	35-44
33998627-3	2021	In this study, a human 3D inflammatory cartilage-on-a-chip model was established to test the therapeutic efficacy of anti-TNFalpha mAb-CS/PAMAM dendrimer NPs loaded-Tyramine-Gellan Gum in the treatment of inflammation.	Tyramine	165-173	tumor necrosis factor	Homo sapiens	122-130
33922836-0	2021	Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics.	Tyramine	20-28	tyrosinase	Homo sapiens	78-88
33890854-4	2021	Here, we demonstrate through high-resolution imaging of intact Drosophila brains that Tyramine induces a reversible remodeling of somatic RNP granules characterized by the decondensation of granule-enriched RBPs (e.g. Imp/ZBP1/IGF2BP) and helicases (e.g. Me31B/DDX-6/Rck).	Tyramine	86-94	maternal expression at 31B	Drosophila melanogaster	255-260
33890854-4	2021	Here, we demonstrate through high-resolution imaging of intact Drosophila brains that Tyramine induces a reversible remodeling of somatic RNP granules characterized by the decondensation of granule-enriched RBPs (e.g. Imp/ZBP1/IGF2BP) and helicases (e.g. Me31B/DDX-6/Rck).	Tyramine	86-94	maternal expression at 31B	Drosophila melanogaster	261-266
33890854-5	2021	Furthermore, our functional analysis reveals that Tyramine signals both through its receptor TyrR and through the calcium-activated kinase CamkII to trigger RNP component decondensation.	Tyramine	50-58	Tyramine receptor	Drosophila melanogaster	93-97
33579534-0	2021	TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.	Tyramine	44-52	trace amine-associated receptor 1	Mus musculus	0-5
33924374-2	2021	A critical first step in energy scavenging from TYR and DGA in Salmonella involves TYR-oxidation via TYR-oxidoreductase and production of free-DGA via beta-glucuronidase (GUS)-mediated hydrolysis of d-glucuronides (conjugated form of DGA), respectively.	Tyramine	48-51	glucuronidase beta	Homo sapiens	151-169
33538092-3	2021	Here, we report our studies on the role of Tyrosine decarboxylase 2 (Tdc2), which converts tyrosine to the catecholamine tyramine, in glial cells in Drosophila alcohol sedation.	Tyramine	121-129	Tyrosine decarboxylase 2	Drosophila melanogaster	43-67
33538092-3	2021	Here, we report our studies on the role of Tyrosine decarboxylase 2 (Tdc2), which converts tyrosine to the catecholamine tyramine, in glial cells in Drosophila alcohol sedation.	Tyramine	121-129	Tyrosine decarboxylase 2	Drosophila melanogaster	69-73
33538092-5	2021	Manipulation of the genes tyramine beta-hydroxylase and tyrosine hydroxylase, which respectively synthesize octopamine and dopamine from tyramine and tyrosine, had no discernable effect on alcohol sedation, suggesting that Tdc2 affects alcohol sedation by regulating tyramine production.	Tyramine	137-145	Tyramine beta hydroxylase	Drosophila melanogaster	26-51
33920848-3	2021	Here, we used an ion channel activation assay to estimate the kons and koffs of four dopamine D2 receptor (D2R) agonists; dopamine (DA), p-tyramine, (R)- and (S)-5-OH-dipropylaminotetralin (DPAT).	Tyramine	137-147	dopamine receptor D2	Homo sapiens	85-105
33920848-3	2021	Here, we used an ion channel activation assay to estimate the kons and koffs of four dopamine D2 receptor (D2R) agonists; dopamine (DA), p-tyramine, (R)- and (S)-5-OH-dipropylaminotetralin (DPAT).	Tyramine	137-147	dopamine receptor D2	Homo sapiens	107-110
33915977-3	2021	TAR1, the prominent player in this system, was initially classified as an octopamine receptor which can also be activated by tyramine, while it later appeared to be a true tyramine receptor.	Tyramine	125-133	trace amine associated receptor 1	Homo sapiens	0-4
33579534-7	2021	Furthermore, tyramine accumulation was higher in TAAR1-KO versus wild-type mice, suggesting a negative feedback mechanism for TAAR1 in sensing tyramine levels.	Tyramine	13-21	trace amine-associated receptor 1	Mus musculus	49-54
33579534-7	2021	Furthermore, tyramine accumulation was higher in TAAR1-KO versus wild-type mice, suggesting a negative feedback mechanism for TAAR1 in sensing tyramine levels.	Tyramine	13-21	trace amine-associated receptor 1	Mus musculus	126-131
33579534-7	2021	Furthermore, tyramine accumulation was higher in TAAR1-KO versus wild-type mice, suggesting a negative feedback mechanism for TAAR1 in sensing tyramine levels.	Tyramine	143-151	trace amine-associated receptor 1	Mus musculus	49-54
33579534-7	2021	Furthermore, tyramine accumulation was higher in TAAR1-KO versus wild-type mice, suggesting a negative feedback mechanism for TAAR1 in sensing tyramine levels.	Tyramine	143-151	trace amine-associated receptor 1	Mus musculus	126-131
33384769-8	2020	Such activation was similar to that already reported for benzylamine, methylamine and tyramine, well-recognized substrates of semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO).	Tyramine	86-94	amine oxidase, copper containing 3	Rattus norvegicus	126-163
33384769-8	2020	Such activation was similar to that already reported for benzylamine, methylamine and tyramine, well-recognized substrates of semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO).	Tyramine	86-94	amine oxidase, copper containing 3	Rattus norvegicus	165-169
31678493-6	2020	We therefore investigated the effect of TAAR ligands on cAMP signalling and insulin secretion, and found that only the branch of the TAAR family tree that is activated by isopentylamine, 2-phenylethylamine, p-tyramine, and agmatine significantly increased intracellular cAMP and resulted in increased insulin secretion from INS-1 cells and primary mouse islets under normal conditions.	Tyramine	207-217	insulin	Homo sapiens	76-83
32334013-0	2020	Involvement of Organic Cation Transporter 2 and a Na+-dependent active transporter in p-tyramine transport across Caco-2 intestinal cells.	Tyramine	86-96	solute carrier family 22 member 2	Homo sapiens	15-43
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	43-53	trace amine associated receptor 1	Homo sapiens	75-108
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	43-53	solute carrier family 22 member 2	Homo sapiens	217-245
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	43-53	solute carrier family 22 member 2	Homo sapiens	247-251
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	55-58	trace amine associated receptor 1	Homo sapiens	75-108
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	55-58	solute carrier family 22 member 2	Homo sapiens	217-245
32334013-1	2020	AIMS: We have previously demonstrated that p-tyramine (TYR), an endogenous trace amine-associated receptor 1 agonist, passage across neuronal membranes involves a transporter exhibiting the pharmacological profile of Organic Cation Transporter 2 (OCT2).	Tyramine	55-58	solute carrier family 22 member 2	Homo sapiens	247-251
32334013-11	2020	SIGNIFICANCE: We have demonstrated for the first time that TYR is transported across Caco-2 apical membranes via facilitated diffusion by OCT2, whereas transport across basolateral membranes is by a Na+-dependent, atropine-sensitive, active transporter.	Tyramine	59-62	solute carrier family 22 member 2	Homo sapiens	138-142
32664213-1	2020	The tyrosinase-catalyzed oxidation of tyramine, leading to the deposition of pseudo-polydopamine (psi-PDA) thin films, is disclosed herein as a superior technology for surface functionalization and coating at a neutral pH and at a low substrate concentration, compared to the standard autoxidative PDA coating protocols.	Tyramine	38-46	tyrosinase	Homo sapiens	4-14
32664213-5	2020	The exposure to a tyramine solution of tyrosinase-loaded alginate spheres, or films deposited on glass or polyethylene, resulted in a rapid gel-confined psi-PDA formation with no leakage or darkening of the solution, allowing the complete recovery and re-utilization of the unreacted tyramine.	Tyramine	18-26	tyrosinase	Homo sapiens	39-49
32664213-5	2020	The exposure to a tyramine solution of tyrosinase-loaded alginate spheres, or films deposited on glass or polyethylene, resulted in a rapid gel-confined psi-PDA formation with no leakage or darkening of the solution, allowing the complete recovery and re-utilization of the unreacted tyramine.	Tyramine	284-292	tyrosinase	Homo sapiens	39-49
32664213-7	2020	The psi-PDA deposition by tyrosinase-catalyzed tyramine oxidation is thus proposed as a controllable and low-waste technology for selective surface functionalization and coating or for clean eumelanin particle production.	Tyramine	47-55	tyrosinase	Homo sapiens	26-36
32233461-3	2020	The presented strategy involves a laccase (oxidoreductase) mediated initial polymerization of 4-hydroxyphenylacetic acid to a homopolymer containing phenolic terminal units, which in turn can be easily reactivated by the same enzyme in the same reaction vessel to continue propagation with a second monomer (tyramine).	Tyramine	308-316	thioredoxin reductase 1	Homo sapiens	43-57
32145505-3	2020	A mixture of EGCG conjugated hyaluronic acids (HA_E) and tyramine conjugated hyaluronic acids (HA_T) was reacted with tyrosinase isolated from Streptomyces avermitillis (SA_Ty) to form that displayed fast enzyme kinetic to form a crosslinked adhesive hydrogel.	Tyramine	57-65	tyrosinase	Homo sapiens	118-128
32072299-3	2020	Tyramine has been determined using its enzymatic reaction with tyramine oxidase (TAO).	Tyramine	0-8	monoamine oxidase B	Homo sapiens	63-79
32072299-3	2020	Tyramine has been determined using its enzymatic reaction with tyramine oxidase (TAO).	Tyramine	0-8	monoamine oxidase B	Homo sapiens	81-84
32072299-9	2020	Graphical abstractTyramine is determined by measuring the plasmon band of the gold nanoparticles formed during its enzymatic reaction with Tyramine oxidase.	Tyramine	18-26	monoamine oxidase B	Homo sapiens	139-155
32942081-1	2020	Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines.	Tyramine	165-173	monoamine oxidase A	Homo sapiens	20-25
32942081-1	2020	Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines.	Tyramine	165-173	monoamine oxidase B	Homo sapiens	30-35
32763247-0	2020	Tyramine and its receptor TYR1 linked behavior QTL to reproductive physiology in honey bee workers (Apis mellifera).	Tyramine	0-8	tyramine receptor	Apis mellifera	26-30
31647557-0	2020	Kinetic and solvent isotope effects in oxidation of halogen derivatives of tyramine catalyzed by monoamine oxidase A.	Tyramine	75-83	monoamine oxidase A	Homo sapiens	97-116
30821508-2	2020	METHODS: DbetaH assay consisted of the enzymatic hydroxylation of tyramine into octopamine, and DA and NE tissues levels were quantified by HPLC-ED.	Tyramine	66-74	dopamine beta-hydroxylase	Rattus norvegicus	9-15
31195313-4	2019	Firstly, tyramine-conjugated GO (GOTA) was synthesized and immobilized onto the surfaces of TiO2 through tyrosinase (Tyr)-catalyzed oxidative reaction (GOTA/TiO2).	Tyramine	9-17	tyrosinase	Homo sapiens	105-115
31570011-3	2019	TYR activates the mammalian trace amine associated receptor 1 (TAAR1).	Tyramine	0-3	trace amine associated receptor 1	Homo sapiens	28-61
31570011-3	2019	TYR activates the mammalian trace amine associated receptor 1 (TAAR1).	Tyramine	0-3	trace amine associated receptor 1	Homo sapiens	63-68
31570011-7	2019	Additionally, TYR elicits significant increases in inflammatory cytokine gene expression in non-polarized and LPS-polarized BMDM, and the TAAR1 antagonist EPPTB inhibits the TYR-mediated upregulation of TAAR1 and inflammatory cytokine gene expression in BMDM.	Tyramine	174-177	trace amine-associated receptor 1	Mus musculus	138-143
31570011-7	2019	Additionally, TYR elicits significant increases in inflammatory cytokine gene expression in non-polarized and LPS-polarized BMDM, and the TAAR1 antagonist EPPTB inhibits the TYR-mediated upregulation of TAAR1 and inflammatory cytokine gene expression in BMDM.	Tyramine	174-177	trace amine-associated receptor 1	Mus musculus	203-208
31693494-10	2019	In addition, tyramine was significantly inversely correlated with multiple biomarkers of inflammation and cardiometabolic risk factors such as RBP4, monocyte TLR-4 abundance and P38MAPKinase activity, body mass index (BMI) and blood pressure (BP) (both systolic and diastolic).	Tyramine	13-21	retinol binding protein 4	Homo sapiens	143-147
31693494-10	2019	In addition, tyramine was significantly inversely correlated with multiple biomarkers of inflammation and cardiometabolic risk factors such as RBP4, monocyte TLR-4 abundance and P38MAPKinase activity, body mass index (BMI) and blood pressure (BP) (both systolic and diastolic).	Tyramine	13-21	toll like receptor 4	Homo sapiens	158-163
31736764-3	2019	In vitro data indicated that the pharmacokinetics of tyramine possibly depend on the organic cation transporter OCT1 genotype and on the CYP2D6 genotype.	Tyramine	53-61	solute carrier family 22 member 1	Homo sapiens	112-116
31736764-3	2019	In vitro data indicated that the pharmacokinetics of tyramine possibly depend on the organic cation transporter OCT1 genotype and on the CYP2D6 genotype.	Tyramine	53-61	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	137-143
31736764-4	2019	Since tyramine is a prototypic substrate of monoamine oxidase A (MAO-A), genetic polymorphisms in MAO-A may also be relevant.	Tyramine	6-14	monoamine oxidase A	Homo sapiens	44-63
31736764-4	2019	Since tyramine is a prototypic substrate of monoamine oxidase A (MAO-A), genetic polymorphisms in MAO-A may also be relevant.	Tyramine	6-14	monoamine oxidase A	Homo sapiens	65-70
31736764-4	2019	Since tyramine is a prototypic substrate of monoamine oxidase A (MAO-A), genetic polymorphisms in MAO-A may also be relevant.	Tyramine	6-14	monoamine oxidase A	Homo sapiens	98-103
31736764-5	2019	The aims of this study were to identify to what extent the interindividual variation in pharmacokinetics and pharmacodynamics of tyramine is determined by genetic polymorphisms in OCT1, CYP2D6, and MAO-A.	Tyramine	129-137	solute carrier family 22 member 1	Homo sapiens	180-184
31736764-5	2019	The aims of this study were to identify to what extent the interindividual variation in pharmacokinetics and pharmacodynamics of tyramine is determined by genetic polymorphisms in OCT1, CYP2D6, and MAO-A.	Tyramine	129-137	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	186-192
31736764-5	2019	The aims of this study were to identify to what extent the interindividual variation in pharmacokinetics and pharmacodynamics of tyramine is determined by genetic polymorphisms in OCT1, CYP2D6, and MAO-A.	Tyramine	129-137	monoamine oxidase A	Homo sapiens	198-203
31736764-6	2019	Beyond that, we wanted to evaluate tyramine as probe drug for the in vivo activity of MAO-A and OCT1.	Tyramine	35-43	monoamine oxidase A	Homo sapiens	86-91
31736764-6	2019	Beyond that, we wanted to evaluate tyramine as probe drug for the in vivo activity of MAO-A and OCT1.	Tyramine	35-43	solute carrier family 22 member 1	Homo sapiens	96-100
32003674-0	2020	Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of alpha-Glucosidase Enzyme.	Tyramine	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	102-119
32003674-1	2020	BACKGROUND: Tyramine derivatives 3-16 were prepared and tested first time for their alpha-glucosidase (Sources: Saccharomyces cerevisiae) inhibitory activity by using an in vitro mechanism-based biochemical assay.	Tyramine	12-20	sucrase isomaltase (alpha-glucosidase)	Mus musculus	84-101
31433402-5	2019	The gelatin-PEG-tyramine (GPT) prepolymer underwent enzymatic crosslinking, which yielded a higher gelation rate of up to 4.24 +- 0.08 s. Second, one-step bioprinting of a cell-laden tubular structure was demonstrated using a coaxial type extruder and the GPT bioink with human umbilical vein endothelial cells (HUVECs) with or without human dermal fibroblasts (HDFs).	Tyramine	16-24	glutamic--pyruvic transaminase	Homo sapiens	26-29
31433402-5	2019	The gelatin-PEG-tyramine (GPT) prepolymer underwent enzymatic crosslinking, which yielded a higher gelation rate of up to 4.24 +- 0.08 s. Second, one-step bioprinting of a cell-laden tubular structure was demonstrated using a coaxial type extruder and the GPT bioink with human umbilical vein endothelial cells (HUVECs) with or without human dermal fibroblasts (HDFs).	Tyramine	16-24	glutamic--pyruvic transaminase	Homo sapiens	256-259
30711102-0	2019	Tyrosinase based amperometric biosensor for determination of tyramine in fermented food and beverages with gold nanoparticle doped poly(8-anilino-1-naphthalene sulphonic acid) modified electrode.	Tyramine	61-69	tyrosinase	Homo sapiens	0-10
33405568-8	2019	Silk fibroin was functionalized with tyramine to enrich the protein"s phenolic side chains, which were subsequently oxidized into catechol groups using mushroom tyrosinase (MT).	Tyramine	37-45	fibroin light chain	Bombyx mori	5-12
30771976-2	2019	The effective fluorescence quenching of UCNPs by melanin-like polymers could detect tyramine and tyrosinase (TYR) activity through the bio-catalysed oxidation of tyramine to the melanin-like polymer products.	Tyramine	162-170	tyrosinase	Homo sapiens	97-107
30771976-2	2019	The effective fluorescence quenching of UCNPs by melanin-like polymers could detect tyramine and tyrosinase (TYR) activity through the bio-catalysed oxidation of tyramine to the melanin-like polymer products.	Tyramine	162-170	tyrosinase	Homo sapiens	109-112
30003648-6	2018	Using cardiomyoblasts and primary cardiomyocytes, we demonstrate that chronic MAO-A activation mediated by synthetic (tyramine) and physiological (NE) substrates induces ROS-dependent DNA damage response, activation of cyclin-dependent kinase inhibitors p21cip , p16ink4a , and p15ink4b and typical features of senescence such as cell flattening and SA-beta-gal activity.	Tyramine	118-126	monoamine oxidase A	Homo sapiens	78-83
30771911-4	2019	Inspired by the changes in both of the solution color and the fluorescence emission due to the sensing between Si NPs and dopamine (DA), we employed tyramine as the model substrate, which can transfer into DA by tyrosinase.	Tyramine	149-157	tyrosinase	Homo sapiens	212-222
30771911-5	2019	It was found that the tyrosinase-incubated tyramine solution exhibited pale yellow under nature light or yellow fluorescence under UV light in the presence of Si NPs, where the color/fluorescence intensity were directly related to the concentration of tyrosinase.	Tyramine	43-51	tyrosinase	Homo sapiens	22-32
30771911-5	2019	It was found that the tyrosinase-incubated tyramine solution exhibited pale yellow under nature light or yellow fluorescence under UV light in the presence of Si NPs, where the color/fluorescence intensity were directly related to the concentration of tyrosinase.	Tyramine	43-51	tyrosinase	Homo sapiens	252-262
29546421-11	2019	It can be hypothesized that if CYP2D6 activity is reduced, tyramine metabolism will decrease, resulting in reduced formation of endogenous dopamine.	Tyramine	59-67	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	31-37
29417334-4	2018	It was revealed early on that selective, even irreversible inhibition of MAO-B is free from the severe side effect of the non-selective MAO inhibitors, the potentiation of tyramine, resulting in the so-called "cheese effect".	Tyramine	172-180	monoamine oxidase B	Homo sapiens	73-78
30808766-7	2019	We further show that the level of tyramine-beta-hydroxylase (TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food deprivation, thus selecting between antagonistic amine actions on motoneurons.	Tyramine	34-42	Tyramine beta hydroxylase	Drosophila melanogaster	61-64
30357655-3	2018	A sensitive UHPLC based method for the estimation of DBH activity in human sera samples based on separation of substrate tyramine from the product octopamine in 3 min is described here.	Tyramine	121-129	dopamine beta-hydroxylase	Homo sapiens	53-56
30039351-10	2018	Indeed, tyramine antilipolytic effect was impaired by MAO-A inhibition.	Tyramine	8-16	monoamine oxidase A	Homo sapiens	54-59
30003648-6	2018	Using cardiomyoblasts and primary cardiomyocytes, we demonstrate that chronic MAO-A activation mediated by synthetic (tyramine) and physiological (NE) substrates induces ROS-dependent DNA damage response, activation of cyclin-dependent kinase inhibitors p21cip , p16ink4a , and p15ink4b and typical features of senescence such as cell flattening and SA-beta-gal activity.	Tyramine	118-126	cyclin dependent kinase inhibitor 2A	Homo sapiens	263-271
30003648-6	2018	Using cardiomyoblasts and primary cardiomyocytes, we demonstrate that chronic MAO-A activation mediated by synthetic (tyramine) and physiological (NE) substrates induces ROS-dependent DNA damage response, activation of cyclin-dependent kinase inhibitors p21cip , p16ink4a , and p15ink4b and typical features of senescence such as cell flattening and SA-beta-gal activity.	Tyramine	118-126	cyclin dependent kinase inhibitor 2B	Homo sapiens	278-286
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	213-221	alkaline phosphatase, placental	Homo sapiens	17-20
30065850-12	2018	These results indicate that tyramine released from RIM inhibits RME via SER-2 signaling.	Tyramine	28-36	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	72-77
30065850-17	2018	Conclusion: We demonstrate that endogenous tyramine downregulates calcium levels in GABAergic RME motor neurons in the head via the tyramine receptor SER-2 during backward locomotion and omega turns.	Tyramine	43-51	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	150-155
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	213-221	tyrosinase	Homo sapiens	25-35
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	213-221	alkaline phosphatase, placental	Homo sapiens	155-158
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	269-277	alkaline phosphatase, placental	Homo sapiens	17-20
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	269-277	tyrosinase	Homo sapiens	25-35
29800522-3	2018	As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol.	Tyramine	269-277	alkaline phosphatase, placental	Homo sapiens	155-158
29114209-0	2017	The Biogenic Amine Tyramine and its Receptor (AmTyr1) in Olfactory Neuropils in the Honey Bee (Apis mellifera) Brain.	Tyramine	19-27	tyramine receptor	Apis mellifera	46-52
29229249-5	2018	Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo.	Tyramine	0-8	tyrosinase	Homo sapiens	92-95
29229249-5	2018	Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo.	Tyramine	10-12	tyrosinase	Homo sapiens	80-90
29229249-5	2018	Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo.	Tyramine	10-12	tyrosinase	Homo sapiens	92-95
29545750-12	2018	In contrast to T1AM, tyramine decreased the phosphorylation of Ser40-TH, while increasing Ser845-GluA1 phosphorylation, actions that were not blocked in TAAR1 KO mice.	Tyramine	21-29	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	97-102
29545750-14	2018	The D1 receptor antagonist SCH23390 blocked tyramine-induced Ser845-GluA1 phosphorylation, but had no effect on tyramine- or beta-PEA-induced Ser40-TH phosphorylation.	Tyramine	44-52	dopamine receptor D1	Mus musculus	4-15
29545750-14	2018	The D1 receptor antagonist SCH23390 blocked tyramine-induced Ser845-GluA1 phosphorylation, but had no effect on tyramine- or beta-PEA-induced Ser40-TH phosphorylation.	Tyramine	44-52	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	68-73
29030339-6	2018	Tyramine reduced LVC in both groups at 10-W exercise (COPD: -3 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) and 20% WLmax (COPD: -4 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) with no difference between groups.	Tyramine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
29030339-6	2018	Tyramine reduced LVC in both groups at 10-W exercise (COPD: -3 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) and 20% WLmax (COPD: -4 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) with no difference between groups.	Tyramine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
29030339-6	2018	Tyramine reduced LVC in both groups at 10-W exercise (COPD: -3 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) and 20% WLmax (COPD: -4 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) with no difference between groups.	Tyramine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
29030339-6	2018	Tyramine reduced LVC in both groups at 10-W exercise (COPD: -3 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) and 20% WLmax (COPD: -4 +- 1 ml min-1 mmHg-1 and controls: -3 +- 1 ml min-1 mmHg-1, P < 0.05) with no difference between groups.	Tyramine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
29577066-5	2018	TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit.	Tyramine	75-83	Tyramine receptor tyra-2	Caenorhabditis elegans	0-6
29577066-6	2018	Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.	Tyramine	178-186	Tyramine receptor tyra-2	Caenorhabditis elegans	66-72
30393170-4	2018	Thus, we tested the effect of dsRNA and siRNA on the tyramine receptor 1 (tyr1), which encodes a receptor of neurotransmitter tyramine, in honey bee brains at mRNA and protein levels over time.	Tyramine	53-61	tyramine receptor	Apis mellifera	74-78
28841980-8	2017	Brushite cement-PPO-GA biosensor resulted in a reliable, highly sensitive, fast, inexpensive and easy analytical method for tyramine detection.	Tyramine	124-132	protoporphyrinogen oxidase	Homo sapiens	16-19
29229249-5	2018	Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo.	Tyramine	0-8	tyrosinase	Homo sapiens	80-90
29375386-3	2017	In vitro, TAAR1 is activated with nanomolar to micromolar affinity by some endogenous amines, particularly p-tyramine, beta-phenylethylamine, and 3-iodothyronamine (T1AM), the latter representing a novel branch of thyroid hormone signaling.	Tyramine	107-117	trace amine associated receptor 1	Homo sapiens	10-15
29375386-6	2017	In particular, beta-phenylethylamine and p-tyramine have been reported to modify the release and/or the response to dopamine, norepinephrine, acetylcholine and GABA, while evidence of cross-talk between TAAR1 and other aminergic receptors has been provided.	Tyramine	41-51	trace amine associated receptor 1	Homo sapiens	203-208
29114209-1	2017	This article describes the cellular sources for tyramine and the cellular targets of tyramine via the Tyramine Receptor 1 (AmTyr1) in the olfactory learning and memory neuropils of the honey bee brain.	Tyramine	48-56	tyramine receptor	Apis mellifera	123-129
29114209-1	2017	This article describes the cellular sources for tyramine and the cellular targets of tyramine via the Tyramine Receptor 1 (AmTyr1) in the olfactory learning and memory neuropils of the honey bee brain.	Tyramine	85-93	tyramine receptor	Apis mellifera	123-129
29114209-7	2017	Release of tyramine/octopamine from VUM (md and mx) neurons in the antennal lobe and mushroom body calyx would target AmTyr1 expressed on ORN and uniglomerular PN presynaptic terminals.	Tyramine	11-19	tyramine receptor	Apis mellifera	118-124
28682929-9	2017	In view of the observed, considerable heterogeneity of enzyme activities, we suggest to determine activities of monoamine oxidase A and B to reduce the risk for tyramine-induced hypertension and the serotonergic syndrome during chronic therapy with rasagiline or safinamide.	Tyramine	161-169	monoamine oxidase A	Homo sapiens	112-131
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	36-44	tyrosinase	Homo sapiens	116-126
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	36-44	tyrosinase	Homo sapiens	352-362
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	137-145	tyrosinase	Homo sapiens	116-126
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	137-145	tyrosinase	Homo sapiens	352-362
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	137-145	tyrosinase	Homo sapiens	116-126
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Tyramine	137-145	tyrosinase	Homo sapiens	352-362
29021745-0	2017	Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase.	Tyramine	0-8	Pyrroline 5-carboyxlate reductase	Drosophila melanogaster	85-94
28634235-6	2017	Using a combination of MS, isotope labeling, and 1H and 13C NMR techniques, we established that the major product, MftA*, is a tyramine-valine-cross-linked peptide formed by MftC through two S-adenosylmethionine-dependent turnovers.	Tyramine	127-135	solute carrier family 25 member 32	Homo sapiens	174-178
28848405-14	2017	This differential effect of tyramine on gustatory responsiveness correlates with a higher natural gustatory responsiveness of foragers, with a higher tyramine receptor (Amtar1) mRNA expression in fat bodies of foragers and with lower baseline tyramine titers in fat bodies of foragers compared to those of nurse bees.	Tyramine	28-36	tyramine receptor	Apis mellifera	150-167
28860630-6	2017	Neurotransmitter receptors previously implicated in C. elegans foraging decisions NPR-1 and TYRA-3, for NPY-like neuropeptides and tyramine respectively, do not appear to be involved in oxytocin-dependent adult food-leaving.	Tyramine	131-139	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	82-87
28860630-6	2017	Neurotransmitter receptors previously implicated in C. elegans foraging decisions NPR-1 and TYRA-3, for NPY-like neuropeptides and tyramine respectively, do not appear to be involved in oxytocin-dependent adult food-leaving.	Tyramine	131-139	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	92-98
27696428-5	2017	The incubation of PPH and TYR in the presence of MTGase exhibited a 52% DPPH radical scavenging activity at 10 mg mL-1 .	Tyramine	26-29	L1 cell adhesion molecule	Mus musculus	114-118
28557441-4	2017	This consists of tyrosinase-oxidized phenolic groups of a heparin derivative (heparin-grafted tyramine, HT) to catechol groups, followed by immobilizing heparin and inducing the in situ Ag NP formation onto poly(urethane) (PU) substrates.	Tyramine	94-102	tyrosinase	Homo sapiens	17-27
27696428-2	2017	This study describes a new method using microbial transglutaminase (MTGase) to covalently link BAs such as histamine (HIS) and tyramine (TYR) to the glutamine residues of alcalase-hydrolyzed pea protein (PPH).	Tyramine	127-135	enolase 1	Homo sapiens	204-207
27355756-2	2016	One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system.	Tyramine	72-80	Tyramine beta hydroxylase	Drosophila melanogaster	106-131
27696428-2	2017	This study describes a new method using microbial transglutaminase (MTGase) to covalently link BAs such as histamine (HIS) and tyramine (TYR) to the glutamine residues of alcalase-hydrolyzed pea protein (PPH).	Tyramine	137-140	enolase 1	Homo sapiens	204-207
27696428-4	2017	Seventy-six % of HIS and 65% of TYR were covalently incorporated to PPH by MTGase.	Tyramine	32-35	enolase 1	Homo sapiens	68-71
28084165-0	2017	Tyramine and beta-phenylethylamine, from fermented food products, as agonists for the human trace amine-associated receptor 1 (hTAAR1) in the stomach.	Tyramine	0-8	trace amine associated receptor 1	Homo sapiens	92-125
28084165-0	2017	Tyramine and beta-phenylethylamine, from fermented food products, as agonists for the human trace amine-associated receptor 1 (hTAAR1) in the stomach.	Tyramine	0-8	trace amine associated receptor 1	Homo sapiens	127-133
28084165-6	2017	The CRE-SEAP reporter assay revealed that only hTAAR1 functioned as a Gs-coupled receptor in response to tyramine and beta-phenylethylamine stimulation.	Tyramine	105-113	trace amine associated receptor 1	Homo sapiens	47-53
28084165-8	2017	These data suggest that tyramine and beta-phenylethylamine in fermented foods act at hTAAR1 as agonists in the pylorus of stomach.	Tyramine	24-32	trace amine associated receptor 1	Homo sapiens	85-91
28740730-5	2017	Aromatic amines, tryptamine, and tyramine activate interleukin-2 but inhibit lysozyme.	Tyramine	33-41	interleukin 15	Gallus gallus	51-64
27942755-0	2017	Tyramine-modified pectins via periodate oxidation for soybean hull peroxidase induced hydrogel formation and immobilization.	Tyramine	0-8	peroxidase	Glycine max	67-77
27942755-3	2017	All tyramine-pectins showed exceptional gelling properties and could form hydrogel both by cross-linking of carboxyl groups with calcium or by cross-linking phenol groups with peroxidase in the presence of hydrogen peroxide.	Tyramine	4-12	peroxidase	Glycine max	176-186
27939988-13	2017	The functional characterization of two tyramine receptors from the honeybee, AmTAR1 (previously named AmTYR1) and AmTAR2, which respond to tyramine by changing cAMP levels in opposite direction, is an important step towards understanding the actions of tyramine in honeybee behavior and physiology, particularly in comparison to the effects of octopamine.	Tyramine	39-47	tyramine receptor	Apis mellifera	102-108
27939988-13	2017	The functional characterization of two tyramine receptors from the honeybee, AmTAR1 (previously named AmTYR1) and AmTAR2, which respond to tyramine by changing cAMP levels in opposite direction, is an important step towards understanding the actions of tyramine in honeybee behavior and physiology, particularly in comparison to the effects of octopamine.	Tyramine	139-147	tyramine receptor	Apis mellifera	102-108
27355756-2	2016	One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system.	Tyramine	72-80	Tyramine beta hydroxylase	Drosophila melanogaster	133-139
27355756-2	2016	One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system.	Tyramine	82-84	Tyramine beta hydroxylase	Drosophila melanogaster	106-131
27355756-2	2016	One of these biogenic amines called octopamine (OA) is synthesized from tyramine (TA) by the catalysis of tyramine-beta-hydroxylase (TbetaH) originated in the insect nervous system.	Tyramine	82-84	Tyramine beta hydroxylase	Drosophila melanogaster	133-139
27901065-1	2016	p-Tyramine is an archetypal member of the endogenous family of monoamines known as trace amines, and is one of the endogenous agonists for trace amine-associated receptor (TAAR)1.	Tyramine	0-10	trace-amine-associated receptor 1	Rattus norvegicus	172-178
26912275-0	2016	Ultrasonic synthesis of tyramine derivatives as novel inhibitors of alpha-glucosidase in vitro.	Tyramine	24-32	sucrase isomaltase (alpha-glucosidase)	Mus musculus	68-85
26912275-12	2016	The current study describes the synthesis alpha-glucosidase inhibitory activity of derivatives, based on a natural product tyramine template.	Tyramine	123-131	sucrase isomaltase (alpha-glucosidase)	Mus musculus	42-59
27901065-8	2016	Using inhibitors of varying selectivity, we identify Organic Cation Transporter 2 (OCT2; SLC22A2) as mediating high affinity uptake of p-tyramine at physiologically relevant concentrations.	Tyramine	135-145	solute carrier family 22 member 2	Rattus norvegicus	53-81
27901065-8	2016	Using inhibitors of varying selectivity, we identify Organic Cation Transporter 2 (OCT2; SLC22A2) as mediating high affinity uptake of p-tyramine at physiologically relevant concentrations.	Tyramine	135-145	solute carrier family 22 member 2	Rattus norvegicus	83-87
27901065-8	2016	Using inhibitors of varying selectivity, we identify Organic Cation Transporter 2 (OCT2; SLC22A2) as mediating high affinity uptake of p-tyramine at physiologically relevant concentrations.	Tyramine	135-145	solute carrier family 22 member 2	Rattus norvegicus	89-96
27901065-10	2016	These results provide the first identification of a high affinity neuronal transporter for p-tyramine, and also confirm the recently described localization of OCT2 in pre-synaptic terminals.	Tyramine	91-101	solute carrier family 22 member 2	Rattus norvegicus	159-163
27498566-8	2016	We conclude that TyrR is a receptor for tyramine, and suggest that it serves to curb high levels of courtship activity through functioning as an inhibitory neuromodulator.	Tyramine	40-48	Tyramine receptor	Drosophila melanogaster	17-21
27828941-4	2016	Tyramine and octopamine released from neurons expressing tyrosine decarboxylase 2 (Tdc2) signal directly to astrocytes to stimulate Ca2+ increases through the octopamine/tyramine receptor (Oct-TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn modulate downstream dopaminergic neurons.	Tyramine	0-8	Octopamine-Tyramine receptor	Drosophila melanogaster	189-197
27828941-4	2016	Tyramine and octopamine released from neurons expressing tyrosine decarboxylase 2 (Tdc2) signal directly to astrocytes to stimulate Ca2+ increases through the octopamine/tyramine receptor (Oct-TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn modulate downstream dopaminergic neurons.	Tyramine	0-8	water witch	Drosophila melanogaster	263-267
27828941-5	2016	Application of tyramine or octopamine to live preparations silenced dopaminergic neurons and this inhibition required astrocytic Oct-TyrR and Wtrw.	Tyramine	15-23	Octopamine-Tyramine receptor	Drosophila melanogaster	129-137
27828941-5	2016	Application of tyramine or octopamine to live preparations silenced dopaminergic neurons and this inhibition required astrocytic Oct-TyrR and Wtrw.	Tyramine	15-23	water witch	Drosophila melanogaster	142-146
27828941-8	2016	Our work identifies Oct-TyrR and Wtrw as key components of the astrocytic Ca2+ signalling machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be mediated by astrocytes, and demonstrates that astrocytes are essential for multiple sensory-driven behaviours in Drosophila.	Tyramine	147-155	Octopamine-Tyramine receptor	Drosophila melanogaster	20-28
27828941-8	2016	Our work identifies Oct-TyrR and Wtrw as key components of the astrocytic Ca2+ signalling machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be mediated by astrocytes, and demonstrates that astrocytes are essential for multiple sensory-driven behaviours in Drosophila.	Tyramine	147-155	water witch	Drosophila melanogaster	33-37
27092049-3	2016	At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1.	Tyramine	227-235	trace amine associated receptor 1	Homo sapiens	49-82
27209590-1	2016	A voltammetric biosensor based on tyrosinase (TYR) was developed for determination of tyramine.	Tyramine	86-94	tyrosinase	Homo sapiens	34-44
27209590-1	2016	A voltammetric biosensor based on tyrosinase (TYR) was developed for determination of tyramine.	Tyramine	86-94	tyrosinase	Homo sapiens	46-49
27209590-5	2016	The biosensor exhibited electrocatalytic activity toward tyramine oxidation within a linear range from 6 to 130 muM, high sensitivity of 486 muA mM(-1) cm(-2), and limit of detection of 1.5 muM.	Tyramine	57-65	latexin	Homo sapiens	112-115
27209590-5	2016	The biosensor exhibited electrocatalytic activity toward tyramine oxidation within a linear range from 6 to 130 muM, high sensitivity of 486 muA mM(-1) cm(-2), and limit of detection of 1.5 muM.	Tyramine	57-65	latexin	Homo sapiens	190-193
27209590-6	2016	The apparent Michaelis-Menten constant was calculated to be 66.0 muM indicating a high biological affinity of the developed biosensor for tyramine.	Tyramine	138-146	latexin	Homo sapiens	65-68
27209590-8	2016	Graphical abstract Different food samples were analyzed to determine tyramine using biosensor based on tyrosinase.	Tyramine	69-77	tyrosinase	Homo sapiens	103-113
27126795-1	2016	Silencing of ODC also led to significantly reduced concentrations of polyamines (putrescine, spermidine and spermine), tyramine and phenolamides (caffeoylputrescine and dicaffeoylspermidine) with concomitant increases in concentrations of amino acids ornithine, arginine, aspartate, glutamate and glutamine.	Tyramine	119-127	ornithine decarboxylase	Nicotiana tabacum	13-16
27092049-3	2016	At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1.	Tyramine	227-235	trace amine associated receptor 1	Homo sapiens	84-89
27031617-1	2016	Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).	Tyramine	77-85	trace amine-associated receptor 1	Mus musculus	155-188
27031617-1	2016	Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).	Tyramine	77-85	trace amine-associated receptor 1	Mus musculus	190-195
26574516-3	2016	The "cheese effect"-paroxysmal hypertension evoked by tyramine-containing foodstuffs-limits clinical use of irreversible MAO-A inhibitors.	Tyramine	54-62	monoamine oxidase A	Rattus norvegicus	121-126
25641750-5	2015	Non-linear fitting of the velocities, determined at various concentrations of substrate (tyramine) and co-substrate (ascorbic acid), and of etamicastat and nepicastat, indicated that the inhibition of DBH by both compounds follows a mixed-model inhibition mechanism, approaching competitive behavior with regards to the substrate tyramine, with K(i) values of 34 and 11 nM, respectively.	Tyramine	89-97	dopamine beta-hydroxylase	Homo sapiens	201-204
26476413-5	2015	Herein, we define the kinetic mechanism for AANATL2 as an ordered sequential mechanism with acetyl-CoA binding first followed by tyramine to generate the ternary complex prior to catalysis.	Tyramine	129-137	Arylalkylamine N-acetyltransferase-like 2	Drosophila melanogaster	44-51
25042749-8	2015	Most toxic histamine and tyramine in fermented lupin and soya bean were found at levels lower those causing adverse health effects.	Tyramine	25-33	5'-nucleotidase, cytosolic IIIA	Homo sapiens	47-52
27118978-7	2016	GST also inhibited hMAO-B tyramine oxidation and hydrogen peroxide production more than hMAO-A.	Tyramine	26-34	monoamine oxidase B	Homo sapiens	19-25
26881018-6	2016	Phenolic compounds fully inhibited the fluorescent detection of H2O2 generated during MAO and SSAO activation by tyramine and benzylamine.	Tyramine	113-121	amine oxidase copper containing 2	Homo sapiens	94-98
26601069-9	2015	Functional characterization showed that T1AM, beta-PEA and p-tyramine (p-Tyr) act as agonists at all tested orthologs, but EC50 values of T1AM at rat Taar1 differed significantly when compared to all other tested vertebrate Taar1.	Tyramine	59-69	trace-amine-associated receptor 1	Rattus norvegicus	224-229
26601069-9	2015	Functional characterization showed that T1AM, beta-PEA and p-tyramine (p-Tyr) act as agonists at all tested orthologs, but EC50 values of T1AM at rat Taar1 differed significantly when compared to all other tested vertebrate Taar1.	Tyramine	71-76	trace-amine-associated receptor 1	Rattus norvegicus	224-229
26601069-11	2015	In contrast, beta-PEA and p-Tyr potencies were rather conserved throughout all tested Taar1 orthologs.	Tyramine	26-31	trace-amine-associated receptor 1	Rattus norvegicus	86-91
25641750-5	2015	Non-linear fitting of the velocities, determined at various concentrations of substrate (tyramine) and co-substrate (ascorbic acid), and of etamicastat and nepicastat, indicated that the inhibition of DBH by both compounds follows a mixed-model inhibition mechanism, approaching competitive behavior with regards to the substrate tyramine, with K(i) values of 34 and 11 nM, respectively.	Tyramine	330-338	dopamine beta-hydroxylase	Homo sapiens	201-204
25426030-1	2014	The trace amines (TAs), tryptamine, tyramine, and beta-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC).	Tyramine	36-44	dopa decarboxylase	Homo sapiens	120-155
25566095-6	2014	beta3-adrenoceptor agonist (BRL37344) reduced baseline vascular resistance, the tyramine-stimulated norepinephrine overflow and the positive inotropic response to tyramine in hypertensive but not normotensive rats.	Tyramine	80-88	adrenoceptor beta 3	Rattus norvegicus	0-18
25566095-6	2014	beta3-adrenoceptor agonist (BRL37344) reduced baseline vascular resistance, the tyramine-stimulated norepinephrine overflow and the positive inotropic response to tyramine in hypertensive but not normotensive rats.	Tyramine	163-171	adrenoceptor beta 3	Rattus norvegicus	0-18
25566095-7	2014	beta3-adrenoceptor antagonist (SR59230A) reduced tyramine-stimulated norepinephrine release in both strains and the secretion of epinephrine in hypertensive rats.	Tyramine	49-57	adrenoceptor beta 3	Rattus norvegicus	0-18
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	Tyramine	215-223	trace amine associated receptor 1	Homo sapiens	0-33
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	Tyramine	215-223	trace amine associated receptor 1	Homo sapiens	35-40
25426030-1	2014	The trace amines (TAs), tryptamine, tyramine, and beta-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC).	Tyramine	36-44	dopa decarboxylase	Homo sapiens	157-161
25426030-3	2014	We first showed that the spinal cord contains the substrates for TA biosynthesis (AADC) and for receptor-mediated actions via trace amine-associated receptors (TAARs) 1 and 4.	Tyramine	65-67	dopa decarboxylase	Homo sapiens	82-86
25017965-4	2014	We find that upon incubation with hydrogen peroxide or the MAO substrate tyramine myoblasts from patients upregulate MAO-B expression and display a significant rise in reactive oxygen species (ROS) levels, with concomitant mitochondrial depolarization.	Tyramine	73-81	monoamine oxidase B	Homo sapiens	117-122
27128224-2	2014	In Period 1, the sensitivity of each subject to orally administered tyramine was established by determining the dose of tyramine that elevates SBP >=30 mmHg on >=3 consecutive occasions (i.e., TYR303 ).	Tyramine	68-76	selenium binding protein 1	Homo sapiens	143-146
24795691-5	2014	By a newly established method, using tyramine-stimulated release through the norepinephrine transporter (NET), presynaptic control of catecholamine release was studied in normotensive and spontaneously hypertensive rats.	Tyramine	37-45	solute carrier family 6 member 2	Rattus norvegicus	77-103
24351130-3	2014	Whereas 2,4-dichlorophenol gives rise to sustained oscillations at 40 muM, it was discovered that tyramine promotes damped oscillations at a concentration of 120 muM.	Tyramine	98-106	latexin	Homo sapiens	162-165
24886880-6	2014	The maximum effect induced by a single concentration of tyramine was diminished in the vas deferens from treated group.	Tyramine	56-64	arginine vasopressin	Rattus norvegicus	87-90
24720993-2	2014	The method is based on the inhibition of TOD that catalyzes the oxidation of tyramine substrate to produce aldehyde and hydrogen peroxide (H2O2).	Tyramine	77-85	monoamine oxidase B	Homo sapiens	41-44
27128224-2	2014	In Period 1, the sensitivity of each subject to orally administered tyramine was established by determining the dose of tyramine that elevates SBP >=30 mmHg on >=3 consecutive occasions (i.e., TYR303 ).	Tyramine	120-128	selenium binding protein 1	Homo sapiens	143-146
23986246-3	2013	TA abolishes the serotonergic sensitization of aversive behavior mediated by the two nociceptive ASH sensory neurons and requires the expression of the adrenergic-like, Galphaq-coupled, TA receptor TYRA-3 on inhibitory monoaminergic and peptidergic neurons.	Tyramine	0-2	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	198-204
25069249-5	2013	TA-associated receptor type 1 (TAAR1) has been shown to have a number of ligands, such as tyramine, PEA, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), and lysergic acid diethylamide (LSD), that may change human mental states.	Tyramine	90-98	trace amine associated receptor 1	Homo sapiens	0-29
23493762-7	2013	The high plasma levels of TYR, a potent agonist of the trace amine associated receptors type 1 (TAAR1), may ultimately down-regulate this receptor because of loss of inhibitory presynaptic regulation, therein resulting in uncontrolled neurotransmitter release.	Tyramine	26-29	trace amine associated receptor 1	Homo sapiens	96-101
25069249-5	2013	TA-associated receptor type 1 (TAAR1) has been shown to have a number of ligands, such as tyramine, PEA, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), and lysergic acid diethylamide (LSD), that may change human mental states.	Tyramine	90-98	trace amine associated receptor 1	Homo sapiens	31-36
23142736-5	2013	Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine beta-hydroxylase (tbetah) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA).	Tyramine	108-116	Bacchus	Drosophila melanogaster	72-76
23567667-1	2013	The lipase-catalyzed molecular hybridization of alpha-lipoic acid (LA) with bioactive compounds pyridoxine, tyrosol and tyramine was performed in ionic solvents and deep eutectic solvents.	Tyramine	120-128	PAN0_003d1715	Moesziomyces antarcticus	4-10
23142736-5	2013	Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine beta-hydroxylase (tbetah) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA).	Tyramine	108-116	Tyramine beta hydroxylase	Drosophila melanogaster	135-141
23142736-5	2013	Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine beta-hydroxylase (tbetah) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA).	Tyramine	202-204	Bacchus	Drosophila melanogaster	72-76
23142736-5	2013	Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine beta-hydroxylase (tbetah) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA).	Tyramine	202-204	Tyramine beta hydroxylase	Drosophila melanogaster	108-133
23142736-5	2013	Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine beta-hydroxylase (tbetah) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA).	Tyramine	202-204	Tyramine beta hydroxylase	Drosophila melanogaster	135-141
24553000-2	2013	Recent in vitro and in vivo studies performed in rodents indicate that dopamine and serotonin may be formed in the brain via alternative CYP2D-mediated pathways, i.e., tyramine hydroxylation and 5-methoxytryptamine O-demethylation, respectively.	Tyramine	168-176	cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)	Homo sapiens	137-142
23252650-4	2013	Similarly, the effective quenching of the AgNCs by quinones enabled the detection of tyrosinase through the biocatalyzed oxidation of tyrosine, dopamine, or tyramine to the respective quinone products.	Tyramine	157-165	tyrosinase	Homo sapiens	85-95
23446525-3	2013	Drosophila kinin is known to act through intracellular calcium, but the mode of action of tyramine is not known.	Tyramine	90-98	Leucokinin	Drosophila melanogaster	11-16
23446525-6	2013	In addition, tyramine signalling to calcium is markedly reduced in mutants of NorpA (a phospholipase C) and itpr, the inositol trisphosphate receptor gene, which we have previously shown to be necessary for Drosophila kinin signalling.	Tyramine	13-21	no receptor potential A	Drosophila melanogaster	78-83
23446525-6	2013	In addition, tyramine signalling to calcium is markedly reduced in mutants of NorpA (a phospholipase C) and itpr, the inositol trisphosphate receptor gene, which we have previously shown to be necessary for Drosophila kinin signalling.	Tyramine	13-21	no receptor potential A	Drosophila melanogaster	87-102
23446525-6	2013	In addition, tyramine signalling to calcium is markedly reduced in mutants of NorpA (a phospholipase C) and itpr, the inositol trisphosphate receptor gene, which we have previously shown to be necessary for Drosophila kinin signalling.	Tyramine	13-21	Leucokinin	Drosophila melanogaster	218-223
23446525-7	2013	Therefore, tyramine and Drosophila kinin signals converge on phospholipase C, and thence on intracellular calcium; and both act to increase chloride shunt conductance by signalling through itpr.	Tyramine	11-19	no receptor potential A	Drosophila melanogaster	61-76
23565061-6	2013	Tyramine temporally coordinates the different phases of the escape response through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynaptic activation of the slow-acting metabotropic receptor, SER-2.	Tyramine	0-8	Ligand-Gated ion Channel	Caenorhabditis elegans	148-154
23565061-6	2013	Tyramine temporally coordinates the different phases of the escape response through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynaptic activation of the slow-acting metabotropic receptor, SER-2.	Tyramine	0-8	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	227-232
21628600-2	2012	Pharmacologic inhibition of monoamine oxidase type A (MAO-A), but not MAO-B, poses a risk of the "cheese effect," a hypertensive response to excess dietary tyramine, a biogenic sympathomimetic amine.	Tyramine	156-164	monoamine oxidase A	Homo sapiens	28-52
21628600-2	2012	Pharmacologic inhibition of monoamine oxidase type A (MAO-A), but not MAO-B, poses a risk of the "cheese effect," a hypertensive response to excess dietary tyramine, a biogenic sympathomimetic amine.	Tyramine	156-164	monoamine oxidase A	Homo sapiens	54-59
21628600-3	2012	Tyramine challenge studies, conducted to characterize rasagiline selectivity for the MAO-B enzyme and tyramine sensitivity, demonstrate that rasagiline, when used at the recommended dose, is selective for MAO-B and is not associated with heightened tyramine sensitivity.	Tyramine	0-8	monoamine oxidase B	Homo sapiens	85-90
21670104-3	2011	TAAR1 is a Galpha(s) protein-coupled receptor that is activated by biogenic amines, "trace amines," such as beta-phenylethylamine (beta-PEA) and tyramine that are normally found at low concentrations in the mammalian brain.	Tyramine	145-153	trace amine associated receptor 1	Homo sapiens	0-5
21651557-1	2011	The cytochrome P450-mediated synthesis of dopamine from tyramine has been shown in vitro.	Tyramine	56-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-19
21651557-2	2011	The aim of the present study was to demonstrate the ability of rat cytochrome P450 (CYP) 2D to synthesize dopamine from tyramine in the brain in vivo.	Tyramine	120-128	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-82
22078410-9	2011	As reversible inhibitors of MAO-A, tetrahydropyridine analogs are at low risk of having an adverse effect of tyramine-induced hypertension.	Tyramine	109-117	monoamine oxidase A	Homo sapiens	28-33
21679153-2	2011	The roles of monoamine oxidase (MAO); flavin-containing monooxygenase (FMO); and cytochrome P450 2D6 (CYP2D6) were studied in terms of the enzymatic elimination of tyramine in vitro at a substrate concentration of 1.0 microM; which is relevant to in vivo serum concentrations.	Tyramine	164-172	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	102-108
21679153-2	2011	The roles of monoamine oxidase (MAO); flavin-containing monooxygenase (FMO); and cytochrome P450 2D6 (CYP2D6) were studied in terms of the enzymatic elimination of tyramine in vitro at a substrate concentration of 1.0 microM; which is relevant to in vivo serum concentrations.	Tyramine	164-172	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	81-100
21679153-5	2011	Among recombinant P450 and FMO enzymes; CYP2D6 had a high activity in terms of tyramine elimination.	Tyramine	79-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	18-30
21679153-5	2011	Among recombinant P450 and FMO enzymes; CYP2D6 had a high activity in terms of tyramine elimination.	Tyramine	79-87	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	40-46
21679153-6	2011	Tyramine elimination rates were inhibited by quinidine and significantly correlated with bufuralol 1"-hydroxylation activities (a CYP2D6 marker).	Tyramine	0-8	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	130-136
21679153-8	2011	The present results suggest that tyramine is eliminated mainly by polymorphic CYP2D6.	Tyramine	33-41	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	78-84
21603928-8	2011	These results suggest that decrease of TA level in the brain likely affects neurons expressing PregOAR/TAR, causing mediation of the sensitivity in the sensillum and/or output of motor neurons for PER.	Tyramine	39-41	tar	Drosophila melanogaster	103-106
21525407-1	2011	The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders.	Tyramine	120-130	trace amine-associated receptor 1	Mus musculus	4-37
21539368-1	2011	Dopamine can be generated from tyramine via arene hydroxylation catalyzed by a cytochrome P450 enzyme (CYP2D6).	Tyramine	31-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-94
21539368-1	2011	Dopamine can be generated from tyramine via arene hydroxylation catalyzed by a cytochrome P450 enzyme (CYP2D6).	Tyramine	31-39	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	103-109
21525407-1	2011	The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders.	Tyramine	120-130	trace amine-associated receptor 1	Mus musculus	39-44
21111850-3	2011	Tyrosinase was employed to convert tyramine-conjugated micelles to highly reactive catechol conjugated micelles that could further cross-link individual Pluronic copolymer micelles to form a highly stable gel structure.	Tyramine	35-43	tyrosinase	Homo sapiens	0-10
21224199-5	2011	If MAO-A inhibition occurs, the body cannot protect itself from exogenous amines such as tyramine.	Tyramine	89-97	monoamine oxidase A	Homo sapiens	3-8
22073124-3	2011	Subtype TAAR1, the best characterized TAAR so far, is promiscuous for a wide set of ligands and is activated by trace amines tyramine (TYR), phenylethylamine (PEA), octopamine (OA), but also by thyronamines, dopamine, and psycho-active drugs.	Tyramine	125-133	trace amine associated receptor 1	Homo sapiens	8-13
22073124-3	2011	Subtype TAAR1, the best characterized TAAR so far, is promiscuous for a wide set of ligands and is activated by trace amines tyramine (TYR), phenylethylamine (PEA), octopamine (OA), but also by thyronamines, dopamine, and psycho-active drugs.	Tyramine	135-138	trace amine associated receptor 1	Homo sapiens	8-13
22073124-5	2011	We, therefore, tested TAAR1 agonists TYR, PEA and OA regarding their effects on ADRB1/2 signaling by co-stimulation studies.	Tyramine	37-40	trace amine associated receptor 1	Homo sapiens	22-27
22073124-5	2011	We, therefore, tested TAAR1 agonists TYR, PEA and OA regarding their effects on ADRB1/2 signaling by co-stimulation studies.	Tyramine	37-40	adrenoceptor beta 1	Homo sapiens	80-85
22073124-6	2011	Surprisingly, trace amines TYR and PEA are partial allosteric antagonists at ADRB1/2, whereas OA is a partial orthosteric ADRB2-antagonist and ADRB1-agonist.	Tyramine	27-30	adrenoceptor beta 1	Homo sapiens	77-84
22073124-6	2011	Surprisingly, trace amines TYR and PEA are partial allosteric antagonists at ADRB1/2, whereas OA is a partial orthosteric ADRB2-antagonist and ADRB1-agonist.	Tyramine	27-30	adrenoceptor beta 1	Homo sapiens	77-82
20590640-4	2010	KEY RESULTS: TYR and beta-PEA reversibly reduced D(2) receptor-activated GIRK currents in a concentration-dependent manner on SNpc neurones.	Tyramine	13-16	dopamine receptor D2	Mus musculus	49-62
20445015-0	2010	Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.	Tyramine	22-30	monoamine oxidase B	Homo sapiens	83-107
19894083-0	2010	limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30.	Tyramine	59-67	monoamine oxidase A	Rattus norvegicus	122-139
19894083-1	2010	One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline.	Tyramine	183-191	monoamine oxidase A	Rattus norvegicus	40-57
19894083-1	2010	One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline.	Tyramine	183-191	monoamine oxidase A	Rattus norvegicus	59-62
19894083-1	2010	One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline.	Tyramine	183-191	monoamine oxidase A	Rattus norvegicus	231-236
20832343-6	2010	Renal microsomes containing CYP2D were able to convert tyramine into dopamine (3.0 nmol/min/g protein) but because of low plasma levels of tyramine this is an unlikely explanation for urinary dopamine excretion in AADC-deficiency.	Tyramine	55-63	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	28-33
20832343-6	2010	Renal microsomes containing CYP2D were able to convert tyramine into dopamine (3.0 nmol/min/g protein) but because of low plasma levels of tyramine this is an unlikely explanation for urinary dopamine excretion in AADC-deficiency.	Tyramine	139-147	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	28-33
20832343-10	2010	This finding can neither be explained by genotype/phenotype correlations nor by alternative metabolic pathways, although small amounts of dopamine may be formed via tyramine hydroxylation by renal CYP2D6.	Tyramine	165-173	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	197-203
20832343-11	2010	CYP2D6-mediated conversion of tyramine into dopamine might be an interesting target for the development of new therapeutic strategies in AADC-deficiency.	Tyramine	30-38	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
20403465-4	2010	An enzyme involved in synephrine biosynthesis, tyrosine decarboxylase (TYDC), is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that decarboxylates tyrosine to yield CO(2) and tyramine.	Tyramine	177-185	pyridoxal phosphatase	Homo sapiens	107-110
20590640-4	2010	KEY RESULTS: TYR and beta-PEA reversibly reduced D(2) receptor-activated GIRK currents in a concentration-dependent manner on SNpc neurones.	Tyramine	13-16	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	73-77
19896925-5	2010	Thymol and carvacrol were then tested and demonstrated to interact with TyrR in desensitizing SER-2 for tyramine activation in [Ca(2+)](i) mobilization assay, and in translocating SER-2 from membrane to cytoplasm in receptor internalization assay.	Tyramine	104-112	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	94-99
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	Tyramine	153-161	monoamine oxidase A	Rattus norvegicus	4-7
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	Tyramine	153-161	monoamine oxidase A	Rattus norvegicus	106-109
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	Tyramine	153-161	monoamine oxidase A	Rattus norvegicus	106-109
20302871-3	2010	Using an expression vector and transient transfections of Spi-OAR into HEK 293 cells, we observed an increase of cAMP upon addition of octopamine and, to a lesser extent, of tyramine, but not after addition of dopamine, serotonin, or histamine.	Tyramine	174-182	chromogranin A	Homo sapiens	58-61
19006188-0	2010	Selective MAO-B inhibitors have low potential for the tyramine effect.	Tyramine	54-62	monoamine oxidase B	Homo sapiens	10-15
20121075-0	2010	In situ forming hydrogels based on tyramine conjugated 4-Arm-PPO-PEO via enzymatic oxidative reaction.	Tyramine	35-43	protoporphyrinogen oxidase	Mus musculus	61-64
19818757-1	2010	The present study was aimed at determining which rat cytochrome P450 (CYP) isoforms are involved in the hydroxylation of tyramine to dopamine and at determining whether the reaction can take place in the brain.	Tyramine	121-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-68
19818757-1	2010	The present study was aimed at determining which rat cytochrome P450 (CYP) isoforms are involved in the hydroxylation of tyramine to dopamine and at determining whether the reaction can take place in the brain.	Tyramine	121-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	70-73
19818757-4	2010	Of the rat CYP isoforms tested, only CYP2D2, 2D4 and 2D18 (but not CYP2D1) were capable of forming dopamine from tyramine.	Tyramine	113-121	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	11-14
19818757-4	2010	Of the rat CYP isoforms tested, only CYP2D2, 2D4 and 2D18 (but not CYP2D1) were capable of forming dopamine from tyramine.	Tyramine	113-121	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	37-43
19818757-4	2010	Of the rat CYP isoforms tested, only CYP2D2, 2D4 and 2D18 (but not CYP2D1) were capable of forming dopamine from tyramine.	Tyramine	113-121	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	67-73
19818757-7	2010	The reaction was inhibited by the CYP2D inhibitor quinine and by anti-CYP2D4 antibodies, which suggests that CYP2D4 is the isoform governing tyramine hydroxylation to dopamine in the rat brain.	Tyramine	141-149	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	70-76
19818757-7	2010	The reaction was inhibited by the CYP2D inhibitor quinine and by anti-CYP2D4 antibodies, which suggests that CYP2D4 is the isoform governing tyramine hydroxylation to dopamine in the rat brain.	Tyramine	141-149	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	109-115
20228998-8	2010	Using a mutation in the tyramine beta hydroxylase (TbetaH[M18]) and blocking of evoked synaptic transmission in the octopamine (and tyramine) neurons labeled with a tyramine decarboxylase-2 (TDC2) gene regulatory elements we found that reinforcement of place memories is independent of normal octopamine signaling.	Tyramine	24-32	Tyramine beta hydroxylase	Drosophila melanogaster	51-57
19450582-4	2009	Recombinant (His)(6)-TyrDC was expressed in Escherichia coli and enzymatically characterized: it exclusively catalyzed the conversion of L-tyrosine to tyramine, exhibited an optimum temperature of 50 degrees C, and an optimum pH at approximately 8.5-9.	Tyramine	151-159	L-tyrosine decarboxylase	Arabidopsis thaliana	21-26
19915121-2	2009	Isolated MTs can respond not only to TA but also to its precursor, tyrosine; this observation led to the proposal that MTs are able to synthesize TA from applied tyrosine through the action of the enzyme tyrosine decarboxylase (TDC).	Tyramine	37-39	Tyrosine decarboxylase 1	Drosophila melanogaster	204-226
19915121-2	2009	Isolated MTs can respond not only to TA but also to its precursor, tyrosine; this observation led to the proposal that MTs are able to synthesize TA from applied tyrosine through the action of the enzyme tyrosine decarboxylase (TDC).	Tyramine	146-148	Tyrosine decarboxylase 1	Drosophila melanogaster	204-226
19915121-2	2009	Isolated MTs can respond not only to TA but also to its precursor, tyrosine; this observation led to the proposal that MTs are able to synthesize TA from applied tyrosine through the action of the enzyme tyrosine decarboxylase (TDC).	Tyramine	146-148	Tyrosine decarboxylase 1	Drosophila melanogaster	228-231
19892733-5	2009	We show that EPPTB prevents the reduction of the firing frequency of DA neurons induced by p-tyramine (p-tyr), a nonselective TAAR1 agonist.	Tyramine	91-101	trace amine-associated receptor 1	Mus musculus	126-131
19574391-3	2009	lgc-55 mutants are defective in a behavior that requires endogenous tyramine, which indicates that this ionotropic tyramine receptor functions in tyramine signaling in vivo.	Tyramine	68-76	Ligand-Gated ion Channel	Caenorhabditis elegans	0-6
19574391-3	2009	lgc-55 mutants are defective in a behavior that requires endogenous tyramine, which indicates that this ionotropic tyramine receptor functions in tyramine signaling in vivo.	Tyramine	115-123	Ligand-Gated ion Channel	Caenorhabditis elegans	0-6
19915121-10	2009	TA synthesis in the MT is the first reported physiological role for Drosophila Tdc1.	Tyramine	0-2	Tyrosine decarboxylase 1	Drosophila melanogaster	79-83
19588076-3	2009	The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine and benzylamine, the favored substrates of AOC3.	Tyramine	94-104	amine oxidase copper containing 2	Homo sapiens	37-41
19386398-0	2009	Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.	Tyramine	14-22	tyrosinase	Homo sapiens	69-79
19386398-2	2009	The prodrugs contained a tyramine or dopamine promoiety required for tyrosinase activation and this was joined via a urea functional group to the cytotoxic triazene.	Tyramine	25-33	tyrosinase	Homo sapiens	69-79
19477148-3	2009	report the characterization of LGC-55 in C. elegans, the first identified tyramine-gated chloride channel.	Tyramine	74-82	Ligand-Gated ion Channel	Caenorhabditis elegans	31-37
19477154-3	2009	Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55.	Tyramine	19-27	Ligand-Gated ion Channel	Caenorhabditis elegans	136-142
19477154-3	2009	Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55.	Tyramine	103-111	Ligand-Gated ion Channel	Caenorhabditis elegans	136-142
19477154-7	2009	Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.	Tyramine	24-32	Ligand-Gated ion Channel	Caenorhabditis elegans	14-20
19519772-3	2009	The potency of p-tyramine and other non-catechols (d-amphetamine, beta-phenethylamine, MPP(+)) in inhibiting cocaine analog binding to DAT in digitonin-treated cells was markedly weakened to a level similar to that observed in cell-free membranes.	Tyramine	15-25	solute carrier family 6 member 3	Homo sapiens	135-138
18678789-2	2008	Rasagiline mesylate is a novel irreversible selective monoamine oxidase type B inhibitor for Parkinson disease that may have a low risk of interaction with dietary tyramine because of its selectivity.	Tyramine	164-172	monoamine oxidase B	Homo sapiens	54-78
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	Tyramine	114-122	monoamine oxidase A	Rattus norvegicus	29-32
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	Tyramine	114-122	monoamine oxidase A	Rattus norvegicus	47-50
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	Tyramine	114-122	monoamine oxidase A	Rattus norvegicus	47-50
18703581-7	2008	Combined infusion of the vasodilatory compounds and the sympathetic vasoconstrictor drug tyramine increased plasma noradrenaline in all hyperaemic conditions, but only caused leg and systemic vasoconstriction and augmented O(2) extraction during adenosine, AMP and ADP infusion (LBF from 3.2 +/- 0.3 to 1.8 +/- 0.2 l min(-1); 3.7 +/- 0.4 to 1.7 +/- 0.2 l min(-1) and 3.3 +/- 0.4 to 2.4 +/- 0.3 l min(-1), respectively, P < 0.05).	Tyramine	89-97	CD59 molecule (CD59 blood group)	Homo sapiens	317-323
18703581-7	2008	Combined infusion of the vasodilatory compounds and the sympathetic vasoconstrictor drug tyramine increased plasma noradrenaline in all hyperaemic conditions, but only caused leg and systemic vasoconstriction and augmented O(2) extraction during adenosine, AMP and ADP infusion (LBF from 3.2 +/- 0.3 to 1.8 +/- 0.2 l min(-1); 3.7 +/- 0.4 to 1.7 +/- 0.2 l min(-1) and 3.3 +/- 0.4 to 2.4 +/- 0.3 l min(-1), respectively, P < 0.05).	Tyramine	89-97	CD59 molecule (CD59 blood group)	Homo sapiens	355-361
18703581-7	2008	Combined infusion of the vasodilatory compounds and the sympathetic vasoconstrictor drug tyramine increased plasma noradrenaline in all hyperaemic conditions, but only caused leg and systemic vasoconstriction and augmented O(2) extraction during adenosine, AMP and ADP infusion (LBF from 3.2 +/- 0.3 to 1.8 +/- 0.2 l min(-1); 3.7 +/- 0.4 to 1.7 +/- 0.2 l min(-1) and 3.3 +/- 0.4 to 2.4 +/- 0.3 l min(-1), respectively, P < 0.05).	Tyramine	89-97	CD59 molecule (CD59 blood group)	Homo sapiens	355-361
19256523-7	2009	Additionally, 1 and tyramine were found to have the same binding mode in rat TAAR(1) despite structure-activity relationship data suggesting the possibility of each molecule having different binding orientations.	Tyramine	20-28	trace-amine-associated receptor 1	Rattus norvegicus	77-84
19325074-6	2009	This receptor encoded by the human TAAR1 gene is also present in rat and mouse genomes (Taar1) and has been shown to be activated by endogenous trace amine ligands, including p-tyramine and beta-phenylethylamine.	Tyramine	175-185	trace amine associated receptor 1	Homo sapiens	35-40
19325074-6	2009	This receptor encoded by the human TAAR1 gene is also present in rat and mouse genomes (Taar1) and has been shown to be activated by endogenous trace amine ligands, including p-tyramine and beta-phenylethylamine.	Tyramine	175-185	trace amine-associated receptor 1	Mus musculus	88-93
18256476-5	2008	These recombinant dmST1, 3, and 4 products showed high sulfating activity toward phenolic compounds such as vanillin and 4-nitrophenol, but showed no activity toward typical endogenous substrates such as tyramine and serotonin.	Tyramine	204-212	Sulfotransferase 1	Drosophila melanogaster	18-23
18430612-10	2008	Norepinephrine was elevated in p75-/- atria, but stimulating norepinephrine release with tyramine produced less tachycardia in p75-/- mice than wild type mice.	Tyramine	89-97	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	127-130
18083911-6	2008	The endogenous TAAR1 agonist p-tyramine specifically decreased the spike frequency of these neurons in wild-type but not in Taar1 knockout mice, consistent with the prominent expression of Taar1 in the ventral tegmental area.	Tyramine	29-39	trace amine-associated receptor 1	Mus musculus	15-20
18083911-6	2008	The endogenous TAAR1 agonist p-tyramine specifically decreased the spike frequency of these neurons in wild-type but not in Taar1 knockout mice, consistent with the prominent expression of Taar1 in the ventral tegmental area.	Tyramine	29-39	trace amine-associated receptor 1	Mus musculus	189-194
18226904-0	2008	Tyramine fragment binding to BACE-1.	Tyramine	0-8	beta-secretase 1	Homo sapiens	29-35
18226904-1	2008	Fragment screening revealed that tyramine binds to the active site of the Alzheimer"s disease drug target BACE-1.	Tyramine	33-41	beta-secretase 1	Homo sapiens	106-112
18180394-12	2008	CONCLUSIONS: Locally infused tyramine produced dose-dependent pressor responses, predicted by family history of hypertension, sex, and genetic variants at loci, particularly CHGB, that encode the biosynthesis, storage, and metabolism of catecholamines.	Tyramine	29-37	chromogranin B	Homo sapiens	174-178
17900709-1	2007	Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons.	Tyramine	21-29	trace amine associated receptor 1	Homo sapiens	109-142
17900709-1	2007	Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons.	Tyramine	21-29	trace amine associated receptor 1	Homo sapiens	144-149
17561096-3	2007	Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis.	Tyramine	36-44	sphingomyelin phosphodiesterase 3	Homo sapiens	142-168
17928454-10	2007	Flight deficits are rescued by substituting octopamine but also by blocking the receptors for tyramine, which is enriched in TbetaH mutants.	Tyramine	94-102	Tyramine beta hydroxylase	Drosophila melanogaster	125-131
17928454-11	2007	Conversely, ablating all neurons containing octopamine or tyramine phenocopies TbetaH mutants.	Tyramine	58-66	Tyramine beta hydroxylase	Drosophila melanogaster	79-85
17868200-3	2007	An exception is the extensive investigation carried out on the inhibition of the metabolism of tyramine, when tyramine-containing food is ingested by subjects taking inhibitors of MAO A or of both MAO A and B.	Tyramine	95-103	monoamine oxidase A	Homo sapiens	180-185
17868200-3	2007	An exception is the extensive investigation carried out on the inhibition of the metabolism of tyramine, when tyramine-containing food is ingested by subjects taking inhibitors of MAO A or of both MAO A and B.	Tyramine	95-103	monoamine oxidase A	Homo sapiens	197-202
17868200-3	2007	An exception is the extensive investigation carried out on the inhibition of the metabolism of tyramine, when tyramine-containing food is ingested by subjects taking inhibitors of MAO A or of both MAO A and B.	Tyramine	110-118	monoamine oxidase A	Homo sapiens	180-185
17868200-3	2007	An exception is the extensive investigation carried out on the inhibition of the metabolism of tyramine, when tyramine-containing food is ingested by subjects taking inhibitors of MAO A or of both MAO A and B.	Tyramine	110-118	monoamine oxidase A	Homo sapiens	197-202
17684049-0	2007	Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans.	Tyramine	0-8	insulin	Homo sapiens	60-67
17684049-7	2007	RESULTS: The acute insulin response to arginine was significantly reduced during tyramine compared with that seen in the absence of tyramine (P = 0.036).	Tyramine	81-89	insulin	Homo sapiens	19-26
17638385-3	2007	Tyramine is synthesized from tyrosine by the enzyme tyrosine decarboxylase (TDC).	Tyramine	0-8	Tyrosine decarboxylase 1	Drosophila melanogaster	52-74
17638385-3	2007	Tyramine is synthesized from tyrosine by the enzyme tyrosine decarboxylase (TDC).	Tyramine	0-8	Tyrosine decarboxylase 1	Drosophila melanogaster	76-79
17561096-1	2007	The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling.	Tyramine	141-149	monoamine oxidase A	Homo sapiens	38-57
17561096-1	2007	The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling.	Tyramine	141-149	monoamine oxidase A	Homo sapiens	59-64
17638385-8	2007	However, flies that contain no measurable neural octopamine and an excess of tyramine due to a null mutation in the tyramine beta-hydroxylase gene (TbetaH(nM18)) exhibit normal locomotor activity and cocaine responses in spite of showing female sterility due to loss of octopamine.	Tyramine	77-85	Tyramine beta hydroxylase	Drosophila melanogaster	116-141
17638385-8	2007	However, flies that contain no measurable neural octopamine and an excess of tyramine due to a null mutation in the tyramine beta-hydroxylase gene (TbetaH(nM18)) exhibit normal locomotor activity and cocaine responses in spite of showing female sterility due to loss of octopamine.	Tyramine	77-85	Tyramine beta hydroxylase	Drosophila melanogaster	148-154
17638385-9	2007	The ability of elevated levels of neural tyramine in TbetaH(nM18) flies to supplant the role of octopamine in adult locomotor and cocaine-induced behaviors, but not in functions related to female fertility, indicates mechanistic differences in the roles of trace amines in these processes.	Tyramine	41-49	Tyramine beta hydroxylase	Drosophila melanogaster	53-59
17561096-3	2007	Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis.	Tyramine	36-44	sphingomyelin phosphodiesterase 3	Homo sapiens	170-177
17561096-3	2007	Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis.	Tyramine	36-44	mitogen-activated protein kinase 3	Homo sapiens	226-232
17561096-4	2007	Silencing MAO-A by siRNA, pharmacological MAO-A inhibitors (pargyline and Ro41-1049), and the antioxidant/ROS scavenger butylated hydroxytoluene (BHT) inhibited the signaling cascade, suggesting that ROS generated during tyramine oxidation by MAO-A are required.	Tyramine	221-229	monoamine oxidase A	Homo sapiens	10-15
17561096-6	2007	Silencing nSMase2 by siRNA did not inhibit ROS generation and MMP2 activation, but blocked SMC proliferation induced by tyramine, suggesting that nSMase2 is downstream MMP2.	Tyramine	120-128	sphingomyelin phosphodiesterase 3	Homo sapiens	10-17
17561096-6	2007	Silencing nSMase2 by siRNA did not inhibit ROS generation and MMP2 activation, but blocked SMC proliferation induced by tyramine, suggesting that nSMase2 is downstream MMP2.	Tyramine	120-128	matrix metallopeptidase 2	Homo sapiens	168-172
17561096-7	2007	These findings demonstrate that H(2)O(2)-generated during tyramine oxidation by MAO-A triggers a stress-induced mitogenic signaling via the MMP2/sphingolipid pathway, which could participate in excessive remodeling and alteration of the vascular wall.	Tyramine	58-66	monoamine oxidase A	Homo sapiens	80-85
17561096-7	2007	These findings demonstrate that H(2)O(2)-generated during tyramine oxidation by MAO-A triggers a stress-induced mitogenic signaling via the MMP2/sphingolipid pathway, which could participate in excessive remodeling and alteration of the vascular wall.	Tyramine	58-66	matrix metallopeptidase 2	Homo sapiens	140-144
17567175-0	2007	Monitoring the activity of tyrosinase on a tyramine/dopamine-functionalized surface by force microscopy.	Tyramine	43-51	tyrosinase	Homo sapiens	27-37
17567175-1	2007	Tyrosinase activity is monitored by pi-donor-acceptor force interactions between a bipyridinium-modified AFM tip and the biocatalytic reaction product generated on a tyramine- (or dopamine-) modified surface.	Tyramine	166-174	tyrosinase	Homo sapiens	0-10
17360588-7	2007	Furthermore, eliminating the expression of Fru(M) by transformer expression in OCT/tyramine neurons changes the aggression versus courtship response behavior.	Tyramine	83-91	fruitless	Drosophila melanogaster	43-46
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	Tyramine	61-74	trace-amine-associated receptor 1	Rattus norvegicus	196-229
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	Tyramine	61-74	trace-amine-associated receptor 1	Rattus norvegicus	231-237
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	Tyramine	76-79	trace-amine-associated receptor 1	Rattus norvegicus	196-229
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	Tyramine	76-79	trace-amine-associated receptor 1	Rattus norvegicus	231-237
17218486-7	2007	PEA was a potent and full agonist at each species of TAAR1, whereas TYR was a full agonist for the rodent TAAR1s but was a partial agonist at h-rChTAAR1.	Tyramine	68-71	trace amine associated receptor 1	Homo sapiens	106-111
17406961-3	2007	Tyramine, which is a substrate for both MAO and SSAO, can also stimulate this process and in that case both MAO and SSAO inhibitors attenuate the effect.	Tyramine	0-8	amine oxidase copper containing 2	Homo sapiens	48-52
17284087-2	2007	However, MAO-A is also inhibited at the high oral dosages needed to effectively treat depression (not an approved indication), necessitating a tyramine-restricted diet.	Tyramine	143-151	monoamine oxidase A	Homo sapiens	9-14
17261052-2	2007	Tyramine is covalently linked to the pattern to yield an encoded nanostructure for the enzyme tyrosinase.	Tyramine	0-8	tyrosinase	Homo sapiens	94-104
17685382-5	2007	The TR-induced oxidation of the tyramine- or 1-functionalized ISFETs resulted in the formation of the redox-active dopaquinone units.	Tyramine	32-40	tyrosinase	Homo sapiens	4-6
17401530-2	2007	With the exception of the inhibition of the metabolism of tyramine ingested by subjects taking inhibitors of MAO-A or of both MAO-A and -B, which has been extensively investigated, the involvement of the monoamine oxidases in xenobiotic amine metabolism (drugs in particular) has been largely neglected.	Tyramine	58-66	monoamine oxidase A	Homo sapiens	109-114
17401530-2	2007	With the exception of the inhibition of the metabolism of tyramine ingested by subjects taking inhibitors of MAO-A or of both MAO-A and -B, which has been extensively investigated, the involvement of the monoamine oxidases in xenobiotic amine metabolism (drugs in particular) has been largely neglected.	Tyramine	58-66	monoamine oxidase A	Homo sapiens	126-138
17406961-3	2007	Tyramine, which is a substrate for both MAO and SSAO, can also stimulate this process and in that case both MAO and SSAO inhibitors attenuate the effect.	Tyramine	0-8	amine oxidase copper containing 2	Homo sapiens	116-120
17056035-3	2006	Interaction with monoamine oxidase (MAO) was investigated by measuring the ability to modulate [(14)C]tyramine oxidation and hydrogen peroxide production.	Tyramine	102-110	monoamine oxidase A	Rattus norvegicus	36-39
17056035-7	2006	Like classical MAO-inhibitors, they were unable to produce hydrogen peroxide and to activate glucose uptake but prevented tyramine to do so in rodent or human adipocytes.	Tyramine	122-130	monoamine oxidase A	Rattus norvegicus	15-18
16807522-1	2006	OBJECTIVES: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine.	Tyramine	124-132	monoamine oxidase B	Homo sapiens	16-35
16979412-6	2006	In addition, tyramine and benzylamine impaired tumor necrosis factor alpha-dependent nitric oxide formation in a pargyline- and semicarbazide-sensitive manner, respectively.	Tyramine	13-21	tumor necrosis factor	Mus musculus	47-74
16527847-9	2006	TYR also increased portal ghrelin [change (Delta), +52 +/- 11%], whereas saline infusion had little effect.	Tyramine	0-3	ghrelin and obestatin prepropeptide	Rattus norvegicus	26-33
16527847-10	2006	We next determined whether the neural stimulation of ghrelin secretion was mediated indirectly via the suppression of insulin secretion during SNS and TYR.	Tyramine	151-154	ghrelin and obestatin prepropeptide	Rattus norvegicus	53-60
16768790-10	2006	They all express tyrosine decarboxylase (required for tyramine and octopamine synthesis) and Drosophila vesicular monoamine transporter (DVMAT).	Tyramine	54-62	Tyrosine decarboxylase 1	Drosophila melanogaster	17-39
16807522-1	2006	OBJECTIVES: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine.	Tyramine	124-132	monoamine oxidase B	Homo sapiens	37-42
16452672-3	2006	We have shown previously that Tbetah(nM18) mutants, with altered levels of octopamine and tyramine, have a locomotion deficit.	Tyramine	90-98	Tyramine beta hydroxylase	Drosophila melanogaster	30-36
16376104-5	2006	While TbetaM efficiently hydroxylates the aliphatic carbon of phenolic amines such as tyramine (the physiological substrate) and dopamine, phenethylamine is a poor substrate.	Tyramine	86-94	Tyramine beta hydroxylase	Drosophila melanogaster	6-12
16185723-2	2005	SERT can operate in reverse direction and be induced by SERT substrates including 5-HT, tyramine and the positively charged methyl-phenylpyridinium (MPP(+)), as well as the amphetamine derivatives para-chloroamphetamine (pCA) and methylene-dioxy-methamphetamine (MDMA).	Tyramine	88-96	solute carrier family 6 member 4	Homo sapiens	0-4
16384907-3	2006	Purified recombinant THT protein catalyzed the synthesis of N-hydroxycinnamic acid amides of tyramine, including feruloyltyramine and p-coumaroyltyramine, but did not accept serotonin as a substrate.	Tyramine	93-101	tyramine N-feruloyltransferase 4/11-like	Capsicum annuum	21-24
16301642-3	2005	We also show that WBC express CYP2D6, an enzyme capable of synthesizing morphine from tyramine, norlaudanosoline, and codeine.	Tyramine	86-94	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	30-36
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	Tyramine	265-275	solute carrier family 6 member 3	Rattus norvegicus	37-57
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	Tyramine	265-275	solute carrier family 6 member 3	Rattus norvegicus	59-62
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	Tyramine	265-275	solute carrier family 6 member 3	Rattus norvegicus	193-196
16185723-2	2005	SERT can operate in reverse direction and be induced by SERT substrates including 5-HT, tyramine and the positively charged methyl-phenylpyridinium (MPP(+)), as well as the amphetamine derivatives para-chloroamphetamine (pCA) and methylene-dioxy-methamphetamine (MDMA).	Tyramine	88-96	solute carrier family 6 member 4	Homo sapiens	56-60
19468644-5	2005	to evaluate vas deferens reactivity to tyramine or norepinephrine, in the absence or presence of ropivacaine.	Tyramine	39-47	arginine vasopressin	Rattus norvegicus	12-15
15968512-0	2005	Characterization of the monophenolase activity of tyrosinase on betaxanthins: the tyramine-betaxanthin/dopamine-betaxanthin pair.	Tyramine	82-90	tyrosinase	Homo sapiens	50-60
15953361-5	2005	Membranes from COS-7 cells expressing TYRA-2 bind [(3)H]tyramine with high affinity with a K(d) of 20 +/- 5 nM.	Tyramine	56-64	Tyramine receptor tyra-2	Caenorhabditis elegans	38-44
15849736-7	2005	Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor.	Tyramine	86-94	Vesicular monoamine transporter	Drosophila melanogaster	46-53
15849736-7	2005	Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor.	Tyramine	86-94	Vesicular monoamine transporter	Drosophila melanogaster	47-51
15953361-7	2005	Indeed, tyramine also dramatically increases GTPgammaS binding to membranes from cells expressing TYRA-2 (EC(50) of 50 +/- 13 nM) and the TA-dependent GTPgammaS binding is PTX-sensitive suggesting that TYRA-2 may couple to Galpha(i/o).	Tyramine	8-16	Tyramine receptor tyra-2	Caenorhabditis elegans	98-104
15953361-7	2005	Indeed, tyramine also dramatically increases GTPgammaS binding to membranes from cells expressing TYRA-2 (EC(50) of 50 +/- 13 nM) and the TA-dependent GTPgammaS binding is PTX-sensitive suggesting that TYRA-2 may couple to Galpha(i/o).	Tyramine	8-16	Tyramine receptor tyra-2	Caenorhabditis elegans	202-208
16180332-7	2005	However, when considering the overall capacity of the fat depots to oxidize tyramine or benzylamine, there was an increase in MAO and SSAO activity only in the enlarged WAT of HFD-induced obese mice.	Tyramine	76-84	amine oxidase, copper containing 3	Mus musculus	134-138
15729684-7	2005	The tyramine-beta-hydroxylase mutant (TbetaH) with increased tyramine and depleted octopamine levels displays normal ethanol sensitivity, a startle repression, and hyperactivates more in response to ethanol.	Tyramine	4-12	Tyramine beta hydroxylase	Drosophila melanogaster	38-44
15729684-10	2005	The comparative analysis of the phenotypes associated with inactive and TbetaH mutants suggests that the fine tuning of ethanol-induced hyperactivity can be correlated with different tyramine levels.	Tyramine	183-191	Tyramine beta hydroxylase	Drosophila melanogaster	72-78
15778090-3	2005	The data indicate that a rapid intracellular degradation of L-3,4-dihydroxyphenylalanine and tyramine (at 100 and 200 microM concentrations) is accompanied by 25-40% decrease in glucose production from pyruvate, alanine + glycerol + octanoate and dihydroxyacetone due to augmented generation of hydrogen peroxide via monoamine oxidase B, resulting in a decline of glutathione redox state by 40%.	Tyramine	93-101	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	317-336
15778090-4	2005	Moreover, following inhibition of monoamine oxidase B by deprenyl or substitution of pyruvate by aspartate + glycerol + octanoate both L-3,4-dihydroxyphenylalanine and tyramine affect neither the rate of gluconeogenesis nor glutathione redox state.	Tyramine	168-176	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	34-53
15764732-5	2005	Cotransfection with the human dopamine transporter enhanced PEA-, amphetamine-, and MDMA-mediated rhTA(1) receptor activation, but it diminished tyramine activation of rhTA(1).	Tyramine	145-153	solute carrier family 6 member 3	Homo sapiens	30-50
15928836-0	2005	Tyramine, benzylamine, and to a lesser extent histamine, partially mimic the adipogenic effect of insulin in a human preadipocyte cell strain.	Tyramine	0-8	insulin	Homo sapiens	98-105
15848803-1	2005	Octopamine biosynthesis requires tyrosine decarboxylase to convert tyrosine into tyramine and tyramine beta-hydroxylase to convert tyramine into octopamine.	Tyramine	81-89	Tyrosine decarboxylase	Caenorhabditis elegans	33-55
15691831-0	2005	Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility.	Tyramine	103-111	Tyrosine decarboxylase 1	Drosophila melanogaster	47-69
15691831-2	2005	Tyramine is synthesized from tyrosine by the enzyme tyrosine decarboxylase (TDC), a member of the aromatic amino acid family, but this enzyme has not been identified in Drosophila or in higher animals.	Tyramine	0-8	Tyrosine decarboxylase 1	Drosophila melanogaster	52-74
15691831-2	2005	Tyramine is synthesized from tyrosine by the enzyme tyrosine decarboxylase (TDC), a member of the aromatic amino acid family, but this enzyme has not been identified in Drosophila or in higher animals.	Tyramine	0-8	Tyrosine decarboxylase 1	Drosophila melanogaster	76-79
15691831-3	2005	To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2.	Tyramine	32-40	Tyrosine decarboxylase 1	Drosophila melanogaster	91-94
15691831-3	2005	To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2.	Tyramine	32-40	Tyrosine decarboxylase 1	Drosophila melanogaster	131-136
15691831-3	2005	To further clarify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila melanogaster, dTdc1 and dTdc2.	Tyramine	32-40	Tyrosine decarboxylase 2	Drosophila melanogaster	141-146
15691831-5	2005	Flies with a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention.	Tyramine	43-51	Tyrosine decarboxylase 2	Drosophila melanogaster	25-30
15691831-9	2005	The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities.	Tyramine	153-161	Tyrosine decarboxylase 2	Drosophila melanogaster	35-40
15500961-7	2004	Serotonin and tyramine, in addition to dopamine, were found to inhibit macroscopic currents at heteromeric NMDA receptors, but not AMPA (GluR1/GluR2) receptors.	Tyramine	14-22	glutamate receptor, ionotropic, AMPA 2 S homeolog	Xenopus laevis	143-148
16076022-6	2005	Tyramine-induced cell death was attenuated by MAO inhibitors as well as with catalase and the iron chelator deferoxamine, suggesting that H202 might mediate the observed toxicity.	Tyramine	0-8	catalase	Homo sapiens	77-85
15569254-3	2004	Membranes prepared from cells expressing either SER-2 or SER-2A bind [3H]lysergic acid diethylamide (LSD) in the low nanomolar range and exhibit highest affinity for tyramine.	Tyramine	166-174	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	48-53
15569254-3	2004	Membranes prepared from cells expressing either SER-2 or SER-2A bind [3H]lysergic acid diethylamide (LSD) in the low nanomolar range and exhibit highest affinity for tyramine.	Tyramine	166-174	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	57-62
15569254-6	2004	Pertussis toxin treatment reduces affinity for both tyramine and octopamine, especially for octopamine in membranes from cells expressing SER-2, suggesting that the conformation of the mid-region of the third intracellular loop is dictated by G-protein interactions and is responsible for the differential tyramine/octopamine affinities of the two isoforms.	Tyramine	52-60	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	138-143
15569254-6	2004	Pertussis toxin treatment reduces affinity for both tyramine and octopamine, especially for octopamine in membranes from cells expressing SER-2, suggesting that the conformation of the mid-region of the third intracellular loop is dictated by G-protein interactions and is responsible for the differential tyramine/octopamine affinities of the two isoforms.	Tyramine	306-314	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	138-143
15569254-8	2004	Tyramine, but not octopamine, also elevates Ca2+ levels in cells expressing SER-2 and to a lesser extent SER-2A.	Tyramine	0-8	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	76-81
15373809-0	2004	Amino acid residues involved in interaction with tyramine in the Bombyx mori tyramine receptor.	Tyramine	49-57	tyramine receptor	Bombyx mori	77-94
15158166-1	2004	Tyramine is a biogenic trace amine that releases monoamines and is a good substrate for monoamine oxidase (MAO)-A/B.	Tyramine	0-8	monoamine oxidase A	Mus musculus	88-115
15126247-4	2004	In the S1 segment, TYR was a more effective inhibitor of TEA uptake than CIM (IC50 values of 39 and 328 microM, respectively), implicating OCT1 as the predominant pathway for TEA transport.	Tyramine	19-22	solute carrier family 22 member 1	Oryctolagus cuniculus	139-143
15234270-9	2004	Detailed kinetic analysis showed SULT1C1 was more prolific in that it was able to sulfate dopamine, tyramine, and apomorphine, which SULT1B1 was not.	Tyramine	100-108	sulfotransferase family, cytosolic, 1C, member 2a	Rattus norvegicus	33-40
15075350-3	2004	In the presence of their substrates, tyramine for MAO and benzylamine for SSAO, intracellular synthesis of H(2)O(2) took place with concomitant inhibition of LPS/IFN-gamma-induced NOS2 protein synthesis, as detected by Western blotting, flow cytometry, and immunofluorescence microscopy analyses.	Tyramine	37-45	monoamine oxidase A	Rattus norvegicus	50-53
15103693-4	2004	DA, Hill coefficient 1.0, and its analogs 3-hydroxyphenethylamine and 4-hydroxyphenethylamine attenuated the effects of PG on the DAT while phenethylamine did not.	Tyramine	70-93	solute carrier family 6 member 3	Rattus norvegicus	130-133
15075350-3	2004	In the presence of their substrates, tyramine for MAO and benzylamine for SSAO, intracellular synthesis of H(2)O(2) took place with concomitant inhibition of LPS/IFN-gamma-induced NOS2 protein synthesis, as detected by Western blotting, flow cytometry, and immunofluorescence microscopy analyses.	Tyramine	37-45	amine oxidase, copper containing 3	Rattus norvegicus	74-78
15075350-3	2004	In the presence of their substrates, tyramine for MAO and benzylamine for SSAO, intracellular synthesis of H(2)O(2) took place with concomitant inhibition of LPS/IFN-gamma-induced NOS2 protein synthesis, as detected by Western blotting, flow cytometry, and immunofluorescence microscopy analyses.	Tyramine	37-45	interferon gamma	Rattus norvegicus	158-171
15075350-3	2004	In the presence of their substrates, tyramine for MAO and benzylamine for SSAO, intracellular synthesis of H(2)O(2) took place with concomitant inhibition of LPS/IFN-gamma-induced NOS2 protein synthesis, as detected by Western blotting, flow cytometry, and immunofluorescence microscopy analyses.	Tyramine	37-45	nitric oxide synthase 2	Rattus norvegicus	180-184
12754108-4	2003	In LPS/IFN-gamma-treated cells, the MAO substrates dopamine (DA) and tyramine caused a concentration-dependent attenuation of NO(2)(-) and NO(3)(-).	Tyramine	69-77	interferon gamma	Rattus norvegicus	7-16
14978721-5	2004	We found that Tbetah(nM18) mutants, with elevated tyramine levels and reduced octopamine levels, had a severe locomotion phenotype.	Tyramine	50-58	Tyramine beta hydroxylase	Drosophila melanogaster	14-20
14978721-7	2004	The locomotion phenotype was partially rescued by feeding Tbetah(nM18) larvae octopamine, an effect that could be nullified with simultaneous feeding of tyramine.	Tyramine	153-161	Tyramine beta hydroxylase	Drosophila melanogaster	58-64
12944320-5	2003	Conversely, OCT1 had a higher affinity for tyramine and pindolol than did OCT2 (21.2 and 2.4 vs. 361 and 50 microM, respectively).	Tyramine	43-51	solute carrier family 22 member 1	Oryctolagus cuniculus	12-16
12944320-9	2003	However, the profile of inhibition of tyramine (an OCT1-selective substrate) transport in single S2 segments indicated that, despite a comparatively low level of expression, OCT1 can play a dominant role in the uptake of selected OC substrates.	Tyramine	38-46	solute carrier family 22 member 1	Oryctolagus cuniculus	51-55
12944320-9	2003	However, the profile of inhibition of tyramine (an OCT1-selective substrate) transport in single S2 segments indicated that, despite a comparatively low level of expression, OCT1 can play a dominant role in the uptake of selected OC substrates.	Tyramine	38-46	solute carrier family 22 member 1	Oryctolagus cuniculus	174-178
14769875-9	2003	The addition of a soluble form of dopamine beta-hydroxylase to the external medium resulted in the successful reconstitution of the hydroxylation activity towards tyramine, an analogue of dopamine, suggesting that a direct electron transfer via complex formation occurred.	Tyramine	163-171	dopamine beta-hydroxylase	Bos taurus	34-59
12855685-1	2003	Monoamine oxidase (MAO) A and B catalyze the oxidative deamination of neuroactive and dietary monoamines such as serotonin, tyramine, and phenylethylamine.	Tyramine	124-132	monoamine oxidase A	Homo sapiens	0-25
15000452-9	2003	As previously reported for other insulin-sensitive processes, such as stimulation of glucose transport or lipolysis inhibition in mature adipocytes, the stimulation of adipogenesis by tyramine and benzylamine was an SSAO-dependent mechanism that apparently shared common signaling pathways with insulin.	Tyramine	184-192	amine oxidase, copper containing 3	Mus musculus	216-220
15000454-12	2003	These results show that the improvement of glucose tolerance induced by prolonged tyramine administration occurs in an insulin-depleted model and probably results from peripheral insulin-like actions of the oxidation of MAO/SSAO substrates, such as the stimulation of glucose uptake into adipocytes.	Tyramine	82-90	monoamine oxidase A	Rattus norvegicus	220-223
15000454-12	2003	These results show that the improvement of glucose tolerance induced by prolonged tyramine administration occurs in an insulin-depleted model and probably results from peripheral insulin-like actions of the oxidation of MAO/SSAO substrates, such as the stimulation of glucose uptake into adipocytes.	Tyramine	82-90	amine oxidase, copper containing 3	Rattus norvegicus	224-228
12897643-0	2003	Pressor response to intravenous tyramine in healthy subjects after safinamide, a novel neuroprotectant with selective, reversible monoamine oxidase B inhibition.	Tyramine	32-40	monoamine oxidase B	Homo sapiens	130-149
12754286-5	2003	Here we report the application of a tyramine/CARD (catalyzed reporter deposition)-enhanced nonradioactive in situ hybridization (ISH) protocol for detection of catalase mRNA in sections of perfusion-fixed, paraffin-embedded rat brain.	Tyramine	36-44	catalase	Rattus norvegicus	160-168
14625153-1	2003	BACKGROUND: The oral administration of monoamine oxidase (MAO) inhibitors has the potential to cause a hypertensive reaction after the ingestion of tyramine-containing compounds.	Tyramine	148-156	monoamine oxidase A	Rattus norvegicus	39-56
14625153-1	2003	BACKGROUND: The oral administration of monoamine oxidase (MAO) inhibitors has the potential to cause a hypertensive reaction after the ingestion of tyramine-containing compounds.	Tyramine	148-156	monoamine oxidase A	Rattus norvegicus	58-61
12707242-7	2003	As expected, forearm vascular resistance increased during the cold pressor test, but tyramine produced forearm vasodilation (4.5+/-1 versus -5+/-1 mm Hg x dL(-1) x min(-1), P<0.03) despite the increase in local norepinephrine spillover.	Tyramine	85-93	CD59 molecule (CD59 blood group)	Homo sapiens	164-170
12754108-4	2003	In LPS/IFN-gamma-treated cells, the MAO substrates dopamine (DA) and tyramine caused a concentration-dependent attenuation of NO(2)(-) and NO(3)(-).	Tyramine	69-77	monoamine oxidase A	Rattus norvegicus	36-39
12686100-3	2003	Substrates of SSAO such as benzylamine or tyramine in combination with vanadate potently stimulate tyrosine phosphorylation of both insulin-receptor substrates 1 (IRS-1) and 3 (IRS-3) and phosphatidylinositol 3-kinase (PI 3-kinase) activity in adipose cells, which occurs in the presence of a weak stimulation of insulin-receptor kinase.	Tyramine	42-50	amine oxidase, copper containing 3	Rattus norvegicus	14-18
12686100-3	2003	Substrates of SSAO such as benzylamine or tyramine in combination with vanadate potently stimulate tyrosine phosphorylation of both insulin-receptor substrates 1 (IRS-1) and 3 (IRS-3) and phosphatidylinositol 3-kinase (PI 3-kinase) activity in adipose cells, which occurs in the presence of a weak stimulation of insulin-receptor kinase.	Tyramine	42-50	insulin receptor substrate 1	Rattus norvegicus	163-175
12686100-3	2003	Substrates of SSAO such as benzylamine or tyramine in combination with vanadate potently stimulate tyrosine phosphorylation of both insulin-receptor substrates 1 (IRS-1) and 3 (IRS-3) and phosphatidylinositol 3-kinase (PI 3-kinase) activity in adipose cells, which occurs in the presence of a weak stimulation of insulin-receptor kinase.	Tyramine	42-50	insulin receptor substrate 3	Rattus norvegicus	177-182
12176961-5	2002	Intracoronary infusion of tyramine resulted in a negligible increase in epinephrine concentration in myocardial interstitial fluid (EPI(MIF)), whereas 30 minutes after infusion of epinephrine an increase of 9.5 nmol/L in EPI(MIF) was observed, indicating that epinephrine is taken up by and released from cardiac sympathetic neurons.	Tyramine	26-34	macrophage migration inhibitory factor	Homo sapiens	132-140
12765230-6	2003	Although dietary restrictions during moclobemide therapy are not considered necessary, the combination of large quantities of moclobemide and tyramine-containing products seems to be lethal, probably because monoamine oxidase-A selectivity is overwhelmed after massive overdoses.	Tyramine	142-150	monoamine oxidase A	Homo sapiens	208-227
15618754-6	2003	Among 11 isoforms of human recombinant P450s, only CYP2D6 exhibited an ability to efficiently convert tyramine which exists in the brain, to dopamine.	Tyramine	102-110	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	51-57
12937847-0	2003	Immunohistochemical detection of dipeptidyl peptidase IV (CD 26) in thyroid neoplasia using biotinylated tyramine amplification.	Tyramine	105-113	dipeptidyl peptidase 4	Homo sapiens	33-56
12937847-0	2003	Immunohistochemical detection of dipeptidyl peptidase IV (CD 26) in thyroid neoplasia using biotinylated tyramine amplification.	Tyramine	105-113	dipeptidyl peptidase 4	Homo sapiens	58-63
12937847-4	2003	DPP IV/CD 26 was assessed in paraffin-embedded thyroid specimens immunohistochemically using commercially available antibody (Serotec) and biotinylated tyramine amplification kit (DAKO).	Tyramine	152-160	dipeptidyl peptidase 4	Homo sapiens	0-6
12937847-9	2003	DPP IV/CD 26 can be assessed immunohistochemically using biotinylated tyramine amplification kit.	Tyramine	70-78	dipeptidyl peptidase 4	Homo sapiens	0-6
12937847-9	2003	DPP IV/CD 26 can be assessed immunohistochemically using biotinylated tyramine amplification kit.	Tyramine	70-78	dipeptidyl peptidase 4	Homo sapiens	7-12
12438548-5	2002	SSAO activity is also widely distributed and present at a lower level than MAO, except in fat depots where both oxidases were equally involved in tyramine oxidation.	Tyramine	146-154	amine oxidase, copper containing 3	Rattus norvegicus	0-4
12354282-6	2002	COS-7 cells expressing SER-2 bind [3H]LSD in the low nM range and exhibit Kis for tyramine, octopamine and serotonin of 0.07, 2, and 13.7 micro m, respectively.	Tyramine	82-90	jagged canonical Notch ligand 2	Homo sapiens	23-28
12354282-7	2002	Significantly, tyramine reduces forskolin-stimulated cAMP levels in HEK293 cells stably expressing SER-2 with an IC50 of about 360 nm, suggesting that SER-2 is a tyramine receptor.	Tyramine	15-23	jagged canonical Notch ligand 2	Homo sapiens	99-104
12354282-7	2002	Significantly, tyramine reduces forskolin-stimulated cAMP levels in HEK293 cells stably expressing SER-2 with an IC50 of about 360 nm, suggesting that SER-2 is a tyramine receptor.	Tyramine	15-23	jagged canonical Notch ligand 2	Homo sapiens	151-156
12444020-4	2003	The most potent of these agonists is tyramine, which is active at low nanomolar concentrations; the pharmacology of this response matches that of the previously published cloned insect tyramine receptor.	Tyramine	37-45	Tyramine receptor	Drosophila melanogaster	185-202
12324691-4	2002	In the 2:3 adduct (8) formed by tris-(2-aminoethyl)amine, and in the 2:1 adduct (9) formed with 2-(4"-hydroxyphenyl)ethylamine (tyramine), where Z" = 1.5 in space group P-1, the hard hydrogen bonds generate three-dimensional structures.	Tyramine	128-136	crystallin gamma F, pseudogene	Homo sapiens	169-172
12423250-3	2002	In human DAT-expressing Xenopus laevis oocytes, repeated exposure to low micromolar concentrations of DA, AMPH or tyramine markedly reduced transport-mediated currents.	Tyramine	114-122	solute carrier family 6 member 3	Homo sapiens	9-12
12183041-3	2002	The effect of tyramine but not of octopamine was selectively abolished in the TyrR mutant hono, suggesting that this gene encodes a receptor for tyramine, and not for octopamine.	Tyramine	14-22	Tyramine receptor	Drosophila melanogaster	78-82
12183041-3	2002	The effect of tyramine but not of octopamine was selectively abolished in the TyrR mutant hono, suggesting that this gene encodes a receptor for tyramine, and not for octopamine.	Tyramine	145-153	Tyramine receptor	Drosophila melanogaster	78-82
12176961-5	2002	Intracoronary infusion of tyramine resulted in a negligible increase in epinephrine concentration in myocardial interstitial fluid (EPI(MIF)), whereas 30 minutes after infusion of epinephrine an increase of 9.5 nmol/L in EPI(MIF) was observed, indicating that epinephrine is taken up by and released from cardiac sympathetic neurons.	Tyramine	26-34	macrophage migration inhibitory factor	Homo sapiens	221-229
12172644-1	2002	Incubation of rat liver mitochondria with 100-500 mM tyramine, a substrate for monoamine oxidases A and B (MAOs), in the presence of 30 mM Ca2+ induces matrix swelling, accompanied by collapse of membrane potential, efflux of endogenous Mg2+ and accumulated Ca2+ and oxidation of endogenous pyridine nucleotides.	Tyramine	53-61	monoamine oxidase A	Rattus norvegicus	79-105
12172644-6	2002	The MAO inhibitors clorgyline (50 mM) and pargyline (500 mM) completely protect against MPT induction by 100 mM tyramine but also inhibit the phenomenon, although with different efficacy, when it is induced by 100 mM Ca2+ in the absence of tyramine.	Tyramine	112-120	monoamine oxidase A	Rattus norvegicus	4-7
12172644-6	2002	The MAO inhibitors clorgyline (50 mM) and pargyline (500 mM) completely protect against MPT induction by 100 mM tyramine but also inhibit the phenomenon, although with different efficacy, when it is induced by 100 mM Ca2+ in the absence of tyramine.	Tyramine	240-248	monoamine oxidase A	Rattus norvegicus	4-7
11919655-0	2002	Is Na(+) required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter?	Tyramine	60-68	solute carrier family 6 member 3	Homo sapiens	98-118
11901210-3	2002	LAT1-mediated [(14)C]phenylalanine uptake was strongly inhibited in a competitive manner by aromatic-amino acid derivatives including L-dopa, alpha-methyldopa, melphalan, triiodothyronine, and thyroxine, whereas phenylalanine methyl ester, N-methyl phenylalanine, dopamine, tyramine, carbidopa, and droxidopa did not inhibit [(14)C]phenylalanine uptake.	Tyramine	274-282	solute carrier family 7 member 5 L homeolog	Xenopus laevis	0-4