PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17622580-0	2007	A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo.	bisdioxopiperazines	46-65	ATPase, class II, type 9A	Mus musculus	85-92
17622580-5	2007	In an attempt to distinguish between these possibilities, we here present a transgenic mouse model aimed at identifying the contribution of topoisomerase IIalpha to the effects of bisdioxopiperazines.	bisdioxopiperazines	180-199	ATPase, class II, type 9A	Mus musculus	154-161
17622580-6	2007	A tyrosine 165 to serine mutation (Y165S) in topoisomerase IIalpha, demonstrated previously to render the human ortholog of this enzyme highly resistant toward bisdioxopiperazines, was introduced at the TOP2A locus in mouse embryonic stem cells by targeted homologous recombination.	bisdioxopiperazines	160-179	ATPase, class II, type 9A	Mus musculus	59-66
17622580-6	2007	A tyrosine 165 to serine mutation (Y165S) in topoisomerase IIalpha, demonstrated previously to render the human ortholog of this enzyme highly resistant toward bisdioxopiperazines, was introduced at the TOP2A locus in mouse embryonic stem cells by targeted homologous recombination.	bisdioxopiperazines	160-179	DNA topoisomerase II alpha	Homo sapiens	203-208
15647268-5	2005	The ATPase activities of human TOP2alpha(Tyr50 --> Phe) and yeast Top2(Tyr28 --> Phe) were resistant to both bisdioxopiperazines and the ATPase inhibitor sodium orthovanadate.	bisdioxopiperazines	115-134	dynein axonemal heavy chain 8	Homo sapiens	4-10
15647268-5	2005	The ATPase activities of human TOP2alpha(Tyr50 --> Phe) and yeast Top2(Tyr28 --> Phe) were resistant to both bisdioxopiperazines and the ATPase inhibitor sodium orthovanadate.	bisdioxopiperazines	115-134	DNA topoisomerase II alpha	Homo sapiens	31-40