PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28686012-4 2017 We also investigated that the loading and release of bFGF from the nanofilm with two parameters (counter-polyanion and film architectures). polyanions 105-114 fibroblast growth factor 2 Homo sapiens 53-57 28607960-7 2017 With the more trypsin-resistant proteins cytochrome c and apomyoglobin, in-membrane proteolysis with short residence times, 1.2 mum membrane pores, and trypsin electrostatically immobilized to an adsorbed polyanion cleaves the proteins after lysine residues in flexible regions. polyanions 205-214 cytochrome c, somatic Homo sapiens 41-53 28551403-4 2017 At higher temperatures, HspB5 and poly(styrene sulfonate) also inhibited endolysin aggregation, though polyanion became less efficient than HspB5 at 55 C and 60 C. However, the polyanion completely protected another protein, glyceraldehyde-3-phosphate dehydrogenase, even at 60 C, in contrast to both natural chaperones whose effect disappeared at 50-55 C. These results provide a platform for the development of artificial chaperones based on synthetic polyelectrolytes. polyanions 103-112 crystallin alpha B Homo sapiens 24-29 28551403-4 2017 At higher temperatures, HspB5 and poly(styrene sulfonate) also inhibited endolysin aggregation, though polyanion became less efficient than HspB5 at 55 C and 60 C. However, the polyanion completely protected another protein, glyceraldehyde-3-phosphate dehydrogenase, even at 60 C, in contrast to both natural chaperones whose effect disappeared at 50-55 C. These results provide a platform for the development of artificial chaperones based on synthetic polyelectrolytes. polyanions 179-188 crystallin alpha B Homo sapiens 24-29 28551403-4 2017 At higher temperatures, HspB5 and poly(styrene sulfonate) also inhibited endolysin aggregation, though polyanion became less efficient than HspB5 at 55 C and 60 C. However, the polyanion completely protected another protein, glyceraldehyde-3-phosphate dehydrogenase, even at 60 C, in contrast to both natural chaperones whose effect disappeared at 50-55 C. These results provide a platform for the development of artificial chaperones based on synthetic polyelectrolytes. polyanions 179-188 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 227-267 27338096-4 2016 Like other serpin-protease partners, C1-INH interaction with C1s is accelerated by polyanions such as heparin. polyanions 83-93 serpin family G member 1 Homo sapiens 37-43 28482498-0 2017 Spontaneous and efficient adsorption of lysozyme from aqueous solutions by naturally polyanion gel beads. polyanions 85-94 lysozyme Homo sapiens 40-48 28530237-4 2017 Here we show that antibodies with binding forces of approximately 60-100 pN activate platelets in the presence of polyanions, while a subset of antibodies from autoimmune-HIT patients with binding forces >=100 pN binds to PF4 alone in the absence of polyanions. polyanions 253-263 platelet factor 4 Homo sapiens 225-228 28530237-5 2017 These antibodies with high binding forces cluster PF4-molecules forming antigenic complexes which allow binding of polyanion-dependent anti-PF4/P-antibodies. polyanions 115-124 platelet factor 4 Homo sapiens 50-53 28530237-5 2017 These antibodies with high binding forces cluster PF4-molecules forming antigenic complexes which allow binding of polyanion-dependent anti-PF4/P-antibodies. polyanions 115-124 platelet factor 4 Homo sapiens 140-143 28379700-1 2017 We have studied the formation and functional properties of polyelectrolyte multilayers where calmodulin (CaM) is used as a polyanion. polyanions 123-132 calmodulin 1 Homo sapiens 93-103 28379700-1 2017 We have studied the formation and functional properties of polyelectrolyte multilayers where calmodulin (CaM) is used as a polyanion. polyanions 123-132 calmodulin 1 Homo sapiens 105-108 27765623-6 2016 The resulting DA-PEI/siSHP-1/pHI-VEGF complexes exhibited the high structural stability against polyanion competition and the improved resistance to digestion by nucleases. polyanions 96-105 vascular endothelial growth factor A Homo sapiens 33-37 27658429-0 2016 Biophysical tools to assess the interaction of PF4 with polyanions. polyanions 56-66 platelet factor 4 Homo sapiens 47-50 27658429-1 2016 The antigen in heparin-induced thrombocytopenia (HIT) is expressed on platelet factor 4 (PF4) when PF4 complexes with polyanions. polyanions 118-128 platelet factor 4 Homo sapiens 89-92 27658429-1 2016 The antigen in heparin-induced thrombocytopenia (HIT) is expressed on platelet factor 4 (PF4) when PF4 complexes with polyanions. polyanions 118-128 platelet factor 4 Homo sapiens 99-102 27658429-3 2016 This allowed identification of those features that make PF4 immunogenic (e. g. a certain conformational change induced by the polyanion, a threshold energy of the complexes, the existence of multimeric complexes, a certain number of bonds formed by PF4 with the polyanion) and to characterize the morphology and thermal stability of complexes formed by the protein with polyanions. polyanions 126-135 platelet factor 4 Homo sapiens 56-59 27658429-3 2016 This allowed identification of those features that make PF4 immunogenic (e. g. a certain conformational change induced by the polyanion, a threshold energy of the complexes, the existence of multimeric complexes, a certain number of bonds formed by PF4 with the polyanion) and to characterize the morphology and thermal stability of complexes formed by the protein with polyanions. polyanions 262-271 platelet factor 4 Homo sapiens 56-59 28347774-0 2017 Polyanion based controlled release system for the GnRH-receptor antagonist degarelix. polyanions 0-9 gonadotropin releasing hormone receptor Rattus norvegicus 50-63 28029772-4 2017 We confirm that in human biological samples, ceruloplasmin activity in serum is decreased in Alzheimer"s disease, but in CSF a reduction of activity in Alzheimer"s disease originates from the polyanion component. polyanions 192-201 ceruloplasmin Homo sapiens 45-58 28325868-2 2017 Polyanions activate IDE toward some substrates, yet an endogenous polyanion activator has not yet been identified. polyanions 0-10 insulin degrading enzyme Homo sapiens 20-23 27338096-4 2016 Like other serpin-protease partners, C1-INH interaction with C1s is accelerated by polyanions such as heparin. polyanions 83-93 complement C1s Homo sapiens 61-64 26186535-0 2015 An Extended Polyanion Activation Surface in Insulin Degrading Enzyme. polyanions 12-21 insulin degrading enzyme Homo sapiens 44-68 27620954-10 2016 FPGS catalyzes the addition of a long polyglutamate chain to folates and antifolates, hence rendering them polyanions which are efficiently retained in the cell and are now bound with enhanced affinity by various folate-dependent enzymes. polyanions 107-117 folylpolyglutamate synthase Homo sapiens 0-4 27393384-3 2016 The actual discrimination is performed by factor H, which has binding sites for polyanions (sialic acids, glycosaminoglycans, phospholipids). polyanions 80-90 complement factor H Homo sapiens 42-50 26016572-7 2015 Polyanions (polyaspartate, polyglutamate, or osteopontin) showed strong growth rate inhibition, but large differences in nucleation and aggregation were observed. polyanions 0-10 secreted phosphoprotein 1 Homo sapiens 45-56 27046148-10 2016 In vitro analysis revealed that factor XIa activates factor XII, and that this reaction is enhanced by polyanions such polyphosphate and nucleic acids. polyanions 103-113 coagulation factor XII (Hageman factor) Mus musculus 53-63 26594418-1 2015 The title double salt containing two distinct, differently protonated hexa-molybdoplatinate(IV) polyanions, Na6[H5.5 alpha-PtMo6O24][H4.5 alpha-PtMo6O24] 29H2O, has been synthesized by a hydro-thermal reaction at ca pH 1.80. polyanions 96-106 hexosaminidase subunit alpha Homo sapiens 70-74 26192629-6 2015 We have established a strong correlation between the structure and dynamics and predict that the formation of flouride polyanion network between Be and F ions and coulomb interaction is responsible for sharp variation of the MS diffusivities which controls the multicomponent diffusion phenomenon in LiF-BeF2 which has a strong impact on the performance of the reactor. polyanions 119-128 LIF interleukin 6 family cytokine Homo sapiens 300-303 25591951-2 2015 Interpolymer interactions between the countercharged polymers like Eudragit EPO (polycation) and hypromellose acetate succinate (polyanion) and Eudragit EPO and hypromellose phthalate (polyanion) were investigated with a view to their use in per oral controlled release drug delivery systems. polyanions 187-196 erythropoietin Homo sapiens 155-158 26186535-8 2015 These findings indicate the presence of multiple polyanion binding modes and suggest the anion-binding surface plays an important conformational role in controlling IDE activity. polyanions 49-58 insulin degrading enzyme Homo sapiens 165-168 24344133-0 2014 Recognition of malondialdehyde-modified proteins by the C terminus of complement factor H is mediated via the polyanion binding site and impaired by mutations found in atypical hemolytic uremic syndrome. polyanions 110-119 complement factor H Homo sapiens 81-89 25345788-1 2014 An alpha1 -Dawson polyanion bearing a lateral side chain with a 4-aminopyridine end group was synthesized. polyanions 18-27 adrenoceptor alpha 1D Homo sapiens 3-9 25220364-0 2014 Polyanion binding accelerates the formation of stable and low-toxic aggregates of ALS-linked SOD1 mutant A4V. polyanions 0-9 superoxide dismutase 1 Homo sapiens 93-97 25220364-9 2014 Although this is only an initial step toward reducing the toxicity of SOD1 mutants, the accelerating role of polyanions in protein aggregation might become one of the rapid pathways that remove toxic forms of SOD1 mutants from intra- and extracellular environments. polyanions 109-119 superoxide dismutase 1 Homo sapiens 70-74 25220364-9 2014 Although this is only an initial step toward reducing the toxicity of SOD1 mutants, the accelerating role of polyanions in protein aggregation might become one of the rapid pathways that remove toxic forms of SOD1 mutants from intra- and extracellular environments. polyanions 109-119 superoxide dismutase 1 Homo sapiens 209-213 25150299-1 2014 The chemokine platelet factor 4 (PF4) undergoes conformational changes when complexing with polyanions. polyanions 92-102 platelet factor 4 Homo sapiens 33-36 24671506-2 2014 Its antigen is formed when the chemokine platelet factor 4 (PF4) complexes with polyanions. polyanions 80-90 platelet factor 4 Homo sapiens 60-63 24671506-3 2014 By assessing polyanions of varying length and degree of sulfation using immunoassay and circular dichroism (CD)-spectroscopy, we show that PF4 structural changes resulting in antiparallel beta-sheet content >30% make PF4/polyanion complexes antigenic. polyanions 13-23 platelet factor 4 Homo sapiens 139-142 24671506-3 2014 By assessing polyanions of varying length and degree of sulfation using immunoassay and circular dichroism (CD)-spectroscopy, we show that PF4 structural changes resulting in antiparallel beta-sheet content >30% make PF4/polyanion complexes antigenic. polyanions 13-22 platelet factor 4 Homo sapiens 139-142 24671506-5 2014 We provide a model suggesting that conformational changes exposing antigens on PF4/polyanion complexes occur in the hairpin involving AA 32-38, which form together with C-terminal AA (66-70) of the adjacent PF4 monomer a continuous patch on the PF4 tetramer surface, explaining why only tetrameric PF4 molecules express "HIT antigens". polyanions 83-92 platelet factor 4 Homo sapiens 79-82 24671506-5 2014 We provide a model suggesting that conformational changes exposing antigens on PF4/polyanion complexes occur in the hairpin involving AA 32-38, which form together with C-terminal AA (66-70) of the adjacent PF4 monomer a continuous patch on the PF4 tetramer surface, explaining why only tetrameric PF4 molecules express "HIT antigens". polyanions 83-92 platelet factor 4 Homo sapiens 207-210 24671506-5 2014 We provide a model suggesting that conformational changes exposing antigens on PF4/polyanion complexes occur in the hairpin involving AA 32-38, which form together with C-terminal AA (66-70) of the adjacent PF4 monomer a continuous patch on the PF4 tetramer surface, explaining why only tetrameric PF4 molecules express "HIT antigens". polyanions 83-92 platelet factor 4 Homo sapiens 207-210 24671506-5 2014 We provide a model suggesting that conformational changes exposing antigens on PF4/polyanion complexes occur in the hairpin involving AA 32-38, which form together with C-terminal AA (66-70) of the adjacent PF4 monomer a continuous patch on the PF4 tetramer surface, explaining why only tetrameric PF4 molecules express "HIT antigens". polyanions 83-92 platelet factor 4 Homo sapiens 207-210 24637705-3 2014 We have redesigned lysozyme"s electrostatic potential field, creating a genetically engineered variant that is less susceptible to polyanion inhibition, yet retains potent bactericidal activity. polyanions 131-140 lysozyme Homo sapiens 19-27 24268243-7 2014 It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems. polyanions 71-80 fibronectin 1 Mus musculus 31-42 23640941-1 2013 Contact to polyanions induces autoactivation of the serine protease factor XII that triggers the kallikrei-kinin system. polyanions 11-21 coagulation factor XII (Hageman factor) Mus musculus 68-78 23861285-1 2013 Multicomponent insulin-containing microparticles are prepared by layer-by-layer assembly of dextran sulfate and chitosan on the core of protein-polyanion complex with or without protease inhibitors. polyanions 144-153 insulin Homo sapiens 15-22 23078372-1 2012 The polyanion of formula {Co(9)(H(2)O)(6)(OH)(3)(HPO(4))(2)(PW(9)O(34))(3)}(16-) (Co(9)) contains a central nonacobalt core held together by hydroxo and hydrogen phosphate bridges and supported by three lacunary Keggin-type polyphosphotungstate ligands. polyanions 4-13 phosphoserine phosphatase pseudogene 1 Homo sapiens 26-31 23673861-1 2013 The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by immunoglobulin G directed against PF4/polyanion complexes. polyanions 76-86 platelet factor 4 Homo sapiens 68-71 23673861-1 2013 The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by immunoglobulin G directed against PF4/polyanion complexes. polyanions 76-86 platelet factor 4 Homo sapiens 211-214 23673861-1 2013 The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by immunoglobulin G directed against PF4/polyanion complexes. polyanions 76-85 platelet factor 4 Homo sapiens 68-71 23673861-1 2013 The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by immunoglobulin G directed against PF4/polyanion complexes. polyanions 76-85 platelet factor 4 Homo sapiens 211-214 23332177-4 2013 Additionally, the DMAE-PRXs with 52 threading CDs (52CD-PRXs) showed greater binding capabilities with siRNA and greater resistance to polyanion competition than 31CD-PRXs, indicating that the highly CD-threaded PRX structure in the 52CD-PRXs is superior in forming stable polyplexes with siRNA. polyanions 135-144 periaxin Homo sapiens 23-26 23078372-1 2012 The polyanion of formula {Co(9)(H(2)O)(6)(OH)(3)(HPO(4))(2)(PW(9)O(34))(3)}(16-) (Co(9)) contains a central nonacobalt core held together by hydroxo and hydrogen phosphate bridges and supported by three lacunary Keggin-type polyphosphotungstate ligands. polyanions 4-13 phosphoserine phosphatase pseudogene 1 Homo sapiens 82-87 22113934-1 2012 Acidic fibroblast growth factor-1 (FGF-1) is an angiogenic protein which requires binding to a polyanion such as heparin for its mitogenic activity and physicochemical stability. polyanions 95-104 fibroblast growth factor 1 Homo sapiens 35-40 22942185-9 2012 As both the lipid A on the surface of Gram-negative bacteria and the amino acids of PF4 contributing to polyanion binding are highly conserved, our results further support the hypothesis that neoepitope formation on PF4 after binding to bacteria is an ancient host defense mechanism. polyanions 104-113 platelet factor 4 Homo sapiens 84-87 22942185-9 2012 As both the lipid A on the surface of Gram-negative bacteria and the amino acids of PF4 contributing to polyanion binding are highly conserved, our results further support the hypothesis that neoepitope formation on PF4 after binding to bacteria is an ancient host defense mechanism. polyanions 104-113 platelet factor 4 Homo sapiens 216-219 22548476-4 2012 PrP(Sc) derived from sheep with V(136)R(154)Q(171)-associated genotypes can be amplified efficiently by PMCA in the presence of additional polyanion such as poly A, but there are no reports that cite ultrasensitive detection of PrP(Sc) derived from sheep of other PrP genotypes. polyanions 139-148 major prion protein Ovis aries 0-3 21954860-0 2011 Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2). polyanions 26-35 fibroblast growth factor 10 Homo sapiens 73-101 21974906-3 2012 The loading of insulin on the microbeads was dependent on the number of insulin layers and the type of polyanions used; higher insulin loading was observed for thicker films and when PVS was used as the polyanion. polyanions 103-113 insulin Homo sapiens 15-22 21974906-3 2012 The loading of insulin on the microbeads was dependent on the number of insulin layers and the type of polyanions used; higher insulin loading was observed for thicker films and when PVS was used as the polyanion. polyanions 103-112 insulin Homo sapiens 15-22 23077523-2 2012 We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by polyanions. polyanions 200-210 insulin degrading enzyme Rattus norvegicus 61-85 23077523-2 2012 We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by polyanions. polyanions 200-210 insulin degrading enzyme Rattus norvegicus 87-90 23077523-4 2012 Based on the structure of IDE, Asn 575 was identified as a potential hydrogen bond partner for Cys904 and mutation of this residue also reduced activity and decreased polyanion activation. polyanions 167-176 insulin degrading enzyme Rattus norvegicus 26-29 21954860-0 2011 Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2). polyanions 26-35 fibroblast growth factor 10 Homo sapiens 103-108 21954860-7 2011 Highly PEGylated polyanions (DS-PEG5) did not bind KGF-2 as well as conjugates with fewer PEG chains. polyanions 17-27 neuronatin Homo sapiens 32-36 21735092-6 2011 CcCK2alpha is capable to utilize GTP and its activity and is inhibited by polyanions and stimulated by polycations in phosphorylation assays, using purified acidic ribosomal protein P1 as a substrate. polyanions 74-84 casein kinase II subunit alpha-like Ceratitis capitata 0-10 21679685-5 2011 Based on the triggering role reported by previous studies of facilitating factors in PrP(C) conversion, e.g., lipid and polyanion, we proposed that the mutation-induced changes may strengthen the interaction between PrP and facilitating factors, which will accelerate PrP conversion and cause PrDs. polyanions 120-129 prion protein Homo sapiens 85-88 21605993-6 2011 We present a model of non-specific electrostatic interactions of FH with polyanion-rich surfaces and specific interactions with C3b, using our computational data and existing experimental data. polyanions 73-82 complement factor H Homo sapiens 65-67 21679685-5 2011 Based on the triggering role reported by previous studies of facilitating factors in PrP(C) conversion, e.g., lipid and polyanion, we proposed that the mutation-induced changes may strengthen the interaction between PrP and facilitating factors, which will accelerate PrP conversion and cause PrDs. polyanions 120-129 prion protein Homo sapiens 216-219 21679685-5 2011 Based on the triggering role reported by previous studies of facilitating factors in PrP(C) conversion, e.g., lipid and polyanion, we proposed that the mutation-induced changes may strengthen the interaction between PrP and facilitating factors, which will accelerate PrP conversion and cause PrDs. polyanions 120-129 prion protein Homo sapiens 216-219 21160168-4 2011 We hypothesized that mucosal host factors such as HD5 an HD6 may alter the activity of polyanion microbicides against HIV. polyanions 87-96 defensin alpha 5 Homo sapiens 50-53 21876254-2 2011 Tau aggregation is dependent on the presence of polyanions, cellular redox state, limited proteolysis, and different posttranslational modifications among which tau phosphorylation plays a particularly important role. polyanions 48-58 microtubule associated protein tau Homo sapiens 0-3 20959601-4 2011 Thus, after binding to bacteria, the endogenous protein PF4 induces antibodies with specificity for PF4/polyanion complexes. polyanions 104-113 platelet factor 4 Homo sapiens 56-59 20959601-4 2011 Thus, after binding to bacteria, the endogenous protein PF4 induces antibodies with specificity for PF4/polyanion complexes. polyanions 104-113 platelet factor 4 Homo sapiens 100-103 21160168-4 2011 We hypothesized that mucosal host factors such as HD5 an HD6 may alter the activity of polyanion microbicides against HIV. polyanions 87-96 defensin alpha 6 Homo sapiens 57-60 20548024-5 2010 These data together with previous findings define a unique binding area exhibiting both polyanion and deoxy-D-ribose recognition properties, located on the inner face of C1q. polyanions 88-97 complement C1q A chain Homo sapiens 170-173 20667715-3 2010 The re-oxidation capacity of partially reduced heptamolybdo-pentavanado-phosphate polyanion (HPA-5(red) or heteropoly blue) by ozone in water and aqueous acetone solution has been examined under conditions simulating pulp bleaching process. polyanions 82-91 integrin subunit alpha 2 Homo sapiens 93-98 20721548-4 2010 PHA polyanions are produced by converting the terminal functional groups into carboxylate groups, while PHA polycations are produced by introducing terminal amino groups. polyanions 4-14 lamin B receptor Homo sapiens 0-3 20808809-4 2010 METHODOLOGY/PRINCIPAL FINDING: In this study a cell-free assay was used to investigate the molecular basis of polyanion stimulated PrP(res) formation using brain tissue or cell line derived murine PrP. polyanions 110-119 prion protein Mus musculus 131-134 20808809-4 2010 METHODOLOGY/PRINCIPAL FINDING: In this study a cell-free assay was used to investigate the molecular basis of polyanion stimulated PrP(res) formation using brain tissue or cell line derived murine PrP. polyanions 110-119 prion protein Mus musculus 197-200 20042707-5 2010 The effects of LMW-HA, but not HMW-HA, on HABP2 activity were inhibited with a peptide of the polyanion-binding domain of HABP2. polyanions 94-103 hyaluronan binding protein 2 Homo sapiens 42-47 20042707-5 2010 The effects of LMW-HA, but not HMW-HA, on HABP2 activity were inhibited with a peptide of the polyanion-binding domain of HABP2. polyanions 94-103 hyaluronan binding protein 2 Homo sapiens 122-127 19519306-2 2009 We found that low pH, certain metals and pesticides, polyanions, polycations and low concentrations of organic solvents cause a significant acceleration of alpha-synuclein fibrillation in the presence of high concentrations of polyethylene glycol. polyanions 53-63 synuclein alpha Homo sapiens 156-171 19645440-1 2009 Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. polyanions 130-140 lysozyme Homo sapiens 95-103 19505131-5 2009 Ion-pair formation between anionic moieties of the polyanion and the metal-coordinated active site is suggested as the dominant mechanism leading to the deactivation of tyrosinase. polyanions 51-60 tyrosinase Homo sapiens 169-179 18801731-3 2008 Here ADAM12, a protease that promotes tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to possess a prodomain/catalytic domain cationic molecular switch, regulated by exogenous heparan sulfate and heparin but also endogenous cell surface proteoglycans and the polyanion, calcium pentosan polysulfate. polyanions 297-306 ADAM metallopeptidase domain 12 Homo sapiens 5-11 19038358-8 2009 Also, the polyanion PRO2000, that was previously shown to prevent HIV entry, inhibits the Grx1- and PDI-dependent reduction of gp120 disulfides. polyanions 10-19 ATPase family AAA domain containing 2 Homo sapiens 20-27 19038358-8 2009 Also, the polyanion PRO2000, that was previously shown to prevent HIV entry, inhibits the Grx1- and PDI-dependent reduction of gp120 disulfides. polyanions 10-19 glutaredoxin Homo sapiens 90-94 19038358-8 2009 Also, the polyanion PRO2000, that was previously shown to prevent HIV entry, inhibits the Grx1- and PDI-dependent reduction of gp120 disulfides. polyanions 10-19 prolyl 4-hydroxylase subunit beta Homo sapiens 100-103 19038358-8 2009 Also, the polyanion PRO2000, that was previously shown to prevent HIV entry, inhibits the Grx1- and PDI-dependent reduction of gp120 disulfides. polyanions 10-19 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 127-132 19124749-0 2009 Polyanion-induced self-association of complement factor H. polyanions 0-9 complement factor H Homo sapiens 49-57 19124749-4 2009 Monomeric human factor H is an extended flexible protein that exhibits an apparent size of 330,000 Da, relative to globular standards, during gel filtration chromatography in the absence of polyanions. polyanions 190-200 complement factor H Homo sapiens 16-24 19124749-11 2009 An expressed fragment encompassing the C-terminal polyanion binding site (complement control protein domains 18-20) also exhibited polyanion-induced self-association, suggesting that the C-terminal ends of factor H mediate self-association. polyanions 50-59 complement factor H Homo sapiens 206-214 19124749-11 2009 An expressed fragment encompassing the C-terminal polyanion binding site (complement control protein domains 18-20) also exhibited polyanion-induced self-association, suggesting that the C-terminal ends of factor H mediate self-association. polyanions 131-140 complement factor H Homo sapiens 206-214 20023744-4 2009 Cleavage of the linker connecting the polyanionic and polycationic domains by specific proteases (tumor associated matrix metalloproteases discussed herein) dissociates the polyanion and enables the cleaved ACPP to enter cells. polyanions 38-47 acid phosphatase, prostate Mus musculus 207-211 18700157-5 2008 Most of the DMAE-SS-PRX polyplexes released the pDNA only in the presence of both 10 mM DTT and of the counter-polyanion, as expected, except for 14DMAE-alpha18-SS-PRX, which released pDNA in the absence of dextran sulfate once the DTT had been added to the polyplex solution. polyanions 111-120 periaxin Homo sapiens 20-23 18235085-1 2008 Mutations in the gene encoding complement factor H (CFH) that alter the C3b/polyanions-binding site in the C-terminal region impair the capacity of factor H to protect host cells. polyanions 76-86 complement factor H Homo sapiens 31-50 18178677-6 2008 In addition, the sensitizing effect of MBP was completely abolished when its cationic charge was neutralized by mixing with a polyanion, such as low-molecular-weight heparin or poly-L-glutamic or poly-L-aspartic acid, before its delivery to the neurons. polyanions 126-135 myelin basic protein Rattus norvegicus 39-42 17705152-9 2008 The potential biological significance of growth hormone polyanion interactions is discussed. polyanions 56-65 growth hormone 1 Homo sapiens 41-55 18235085-1 2008 Mutations in the gene encoding complement factor H (CFH) that alter the C3b/polyanions-binding site in the C-terminal region impair the capacity of factor H to protect host cells. polyanions 76-86 complement factor H Homo sapiens 52-55 18235085-1 2008 Mutations in the gene encoding complement factor H (CFH) that alter the C3b/polyanions-binding site in the C-terminal region impair the capacity of factor H to protect host cells. polyanions 76-86 complement factor H Homo sapiens 42-50 17330862-6 2007 A comparison of the effects of small anions and polyanions demonstrates the importance of cooperativity among the anions in the destabilization of cyt c. polyanions 48-58 cytochrome c, somatic Homo sapiens 147-152 18081691-7 2008 In one plausible model, CCP 20 anchors CFH to self-surfaces via a C3b/polyanion composite binding site, CCP 7 acts as a "proof-reader" to help discriminate self- from non-self patterns of sulphation, and CCPs 1-4 disrupt C3/C5 convertase formation and stability. polyanions 70-79 complement factor H Homo sapiens 39-42 19213321-3 2008 Moreover, coadsorption with polyanions results in an increase of charge in the Cu UPD region. polyanions 28-38 uroporphyrinogen decarboxylase Homo sapiens 82-85 17916573-3 2008 Thus, a better understanding of PA/PABP interactions may not only enhance our understandings of biological systems but also provide new clues to these deadly diseases. polyanions 32-34 poly(A) binding protein cytoplasmic 1 Homo sapiens 35-39 18023464-6 2008 The PLA(2) and proteolytic activities of B. jararacussu crude venom were also inhibited in a concentration-dependent way by suramin, showing that this polyanion antivenom activity has therapeutic potential to be used as an antivenom. polyanions 151-160 phospholipase A2 group IB Rattus norvegicus 4-10 17330862-0 2007 Characterization of the polyanion-induced molten globule-like state of cytochrome c. polyanions 24-33 cytochrome c, somatic Homo sapiens 71-83 17298300-2 2007 Negatively charged polyanions lead to autoactivation of the FSAP, but no information is available concerning the potential regulation of FSAP activity and its metabolism in the vessel wall. polyanions 19-29 hyaluronan binding protein 2 Homo sapiens 60-64 17397238-9 2007 The effect of several high- and low-molecular mass polyanions on the thermal stability of FGF20 is also examined using CD, intrinsic fluorescence, and DSC analysis. polyanions 51-61 fibroblast growth factor 20 Homo sapiens 90-95 17300216-2 2007 The auto-activation of FSAP is facilitated by negatively charged polyanions such as heparin, dextransulfate or extracellular ribonucleic acids. polyanions 65-75 hyaluronan binding protein 2 Homo sapiens 23-27 17094125-0 2007 Effect of polyanions on the structure and stability of repifermin (keratinocyte growth factor-2). polyanions 10-20 fibroblast growth factor 10 Homo sapiens 67-95 17094125-3 2007 In these studies, we examine the effect of several polyanions on the structure and stability of keratinocyte growth factor 2 (KGF-2, FGF-10), a candidate for use as a wound-healing agent. polyanions 51-61 fibroblast growth factor 10 Homo sapiens 96-124 17094125-3 2007 In these studies, we examine the effect of several polyanions on the structure and stability of keratinocyte growth factor 2 (KGF-2, FGF-10), a candidate for use as a wound-healing agent. polyanions 51-61 fibroblast growth factor 10 Homo sapiens 126-131 17094125-3 2007 In these studies, we examine the effect of several polyanions on the structure and stability of keratinocyte growth factor 2 (KGF-2, FGF-10), a candidate for use as a wound-healing agent. polyanions 51-61 fibroblast growth factor 10 Homo sapiens 133-139 17320040-5 2007 When bound to a CldAMP-substituted TATA box, however, the TBP complex was more resistant to polyanions, suggesting enhanced stability. polyanions 92-102 TATA-box binding protein Homo sapiens 58-61 17352500-1 2007 This work describes the immobilization of beta-galactosidase onto polyelectrolyte multilayer assemblies of the polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and the polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA). polyanions 111-120 galactosidase beta 1 Homo sapiens 42-60 19164903-4 2007 We also discuss in this review the role of phosphorylation for the aggregation of the neuronal Tau protein, and compare it to the aggregation induced by external poly anions. polyanions 162-173 microtubule associated protein tau Homo sapiens 95-98 17605281-4 2007 The starting point seems to be the accumulation of polyanions in the elastin of the cribriform plate, followed by disruption of axonal transport, mitochondrial extrusion and subsequent formation of optic disc drusen. polyanions 51-61 elastin Homo sapiens 69-76 17042049-0 2006 P(8) (8-) polyanion with phosphorus atoms in three different formal oxidation states stabilized by a combination of Ag(+) and Hg(2+) cations. polyanions 10-19 S100 calcium binding protein A8 Homo sapiens 0-4 17176051-7 2006 Global effects of polyanions on FGF-10 flexibility, thermodynamic fluctuations, and hydration vary depending on the size and charge density of the polyanion. polyanions 18-27 fibroblast growth factor 10 Homo sapiens 32-38 17176051-10 2006 Similarly, time-resolved spectroscopy reveals increased ground state heterogeneity and increased dipole relaxation on the time scale of fluorescence for FGF-10 in the presence of polyanions. polyanions 179-189 fibroblast growth factor 10 Homo sapiens 153-159 16873726-7 2006 CONCLUSIONS: HIT antigens are formed when charge neutralization by polyanion allows positively charged PF4 tetramers to undergo close approximation. polyanions 67-76 platelet factor 4 Homo sapiens 103-106 17099866-10 2006 In-situ ATR FT-IR spectroscopy revealed that the adsorbed amount of HSA and LYZ under attractive conditions was significantly higher than under repulsive ones, which is analogous to protein adsorption at polyelectrolyte multilayers terminated either by polycation or polyanion. polyanions 267-276 lysozyme Homo sapiens 76-79 16873726-1 2006 OBJECTIVE: Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by antibodies that recognize positively charged platelet factor 4 (PF4), bound to the polyanion, heparin. polyanions 176-185 platelet factor 4 Homo sapiens 157-160 16882346-5 2006 Here we have evaluated two candidate polyanion compounds in clinical trials, PRO 2000 and dextrin sulphate (DxS) to determine their safety and efficacy against in vitro HIV-1 and HSV-2 infection using cellular and tissue explant models. polyanions 37-46 ATPase family AAA domain containing 2 Homo sapiens 77-85 16873726-5 2006 METHODS AND RESULTS: By atomic force microscopy and photon correlation spectroscopy, we show that with any of the 3 polyanions, but in the order, UFH>LMWH>>fondaparinux--PF4 forms clusters in which PF4 tetramers become closely apposed, and to which anti-PF4/heparin antibodies bind. polyanions 116-126 platelet factor 4 Homo sapiens 179-182 16873726-5 2006 METHODS AND RESULTS: By atomic force microscopy and photon correlation spectroscopy, we show that with any of the 3 polyanions, but in the order, UFH>LMWH>>fondaparinux--PF4 forms clusters in which PF4 tetramers become closely apposed, and to which anti-PF4/heparin antibodies bind. polyanions 116-126 platelet factor 4 Homo sapiens 207-210 16873726-5 2006 METHODS AND RESULTS: By atomic force microscopy and photon correlation spectroscopy, we show that with any of the 3 polyanions, but in the order, UFH>LMWH>>fondaparinux--PF4 forms clusters in which PF4 tetramers become closely apposed, and to which anti-PF4/heparin antibodies bind. polyanions 116-126 platelet factor 4 Homo sapiens 207-210 16982928-6 2006 Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge. polyanions 47-56 matrix metallopeptidase 1 Homo sapiens 110-115 16982928-6 2006 Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge. polyanions 47-56 myelin basic protein Homo sapiens 159-162 16982928-6 2006 Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge. polyanions 47-56 eosinophil peroxidase Homo sapiens 168-171 16982928-6 2006 Finally, simultaneous cell incubation with the polyanion molecules, poly-L-glutamic acid or heparin, restored MMP-1 gene expression but incompletely inhibited MBP- and EPO-induced transcriptional effects as well as endothelin-1 and PDGF-AB release, suggesting that cationic proteins act partially through their cationic charge. polyanions 47-56 endothelin 1 Homo sapiens 215-227 16977390-3 2006 Chitosan (Chi) and poly (styrene sulfonate, sodium salt) (PSS) were utilized as polycation and polyanion in this study, respectively. polyanions 95-104 PSS Homo sapiens 58-61 16723115-1 2006 It has recently been reported that insulin-degrading enzyme (IDE) contains an allosteric site which binds polyanions such as ATP and PPPi. polyanions 106-116 insulin degrading enzyme Homo sapiens 35-59 16723115-1 2006 It has recently been reported that insulin-degrading enzyme (IDE) contains an allosteric site which binds polyanions such as ATP and PPPi. polyanions 106-116 insulin degrading enzyme Homo sapiens 61-64 16307432-1 2005 The ability of synthetic polyanions to suppress thermo-aggregation of the oligomeric enzymes (glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, and aspartate aminotransferase) has been established. polyanions 25-35 LOC786101 Bos taurus 94-134 16711753-3 2006 Several studies have been performed to elucidate the mechanism of the anti-HIV-1 activity of sulfated polysaccharides and polyanions in general, including binding to cell surface CD4 and interfering with the gp120-coreceptor interaction. polyanions 122-132 CD4 molecule Homo sapiens 179-182 16711753-3 2006 Several studies have been performed to elucidate the mechanism of the anti-HIV-1 activity of sulfated polysaccharides and polyanions in general, including binding to cell surface CD4 and interfering with the gp120-coreceptor interaction. polyanions 122-132 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 208-213 16519733-5 2006 Variability in the blocking of CD4 mAb binding by sulfated polyanions indicated differences in exofacial CD4 structures. polyanions 59-69 CD4 molecule Homo sapiens 31-34 16519733-5 2006 Variability in the blocking of CD4 mAb binding by sulfated polyanions indicated differences in exofacial CD4 structures. polyanions 59-69 CD4 molecule Homo sapiens 105-108 16246549-0 2006 Specific volume and compressibility of human serum albumin-polyanion complexes. polyanions 59-68 albumin Homo sapiens 45-58 17147270-6 2006 The study of the inhibitory effect of such polyanions as ATP and dextran sulfate (DS) upon thrombin-catalyzed cleavages of fibrinogen has shown that the growth of the negative charge of the polyanion molecule resulted in the increase of its inhibitory activity. polyanions 43-53 coagulation factor II, thrombin Homo sapiens 91-99 17147270-6 2006 The study of the inhibitory effect of such polyanions as ATP and dextran sulfate (DS) upon thrombin-catalyzed cleavages of fibrinogen has shown that the growth of the negative charge of the polyanion molecule resulted in the increase of its inhibitory activity. polyanions 43-52 coagulation factor II, thrombin Homo sapiens 91-99 16533809-0 2006 Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure. polyanions 55-64 complement factor H Homo sapiens 92-100 16533809-7 2006 It is intriguing that a single nucleotide polymorphism predisposing to age-related macular degeneration occupies another region of factor H that harbors a polyanion-binding site. polyanions 155-164 complement factor H Homo sapiens 131-139 16332249-0 2006 A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding. polyanions 130-139 hyaluronan binding protein 2 Homo sapiens 75-105 16332249-0 2006 A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding. polyanions 130-139 hyaluronan binding protein 2 Homo sapiens 107-111 16332249-4 2006 A proteolysis approach, where FSAP was hydrolysed into smaller fragments, was used to identify the polyanion-binding site. polyanions 99-108 hyaluronan binding protein 2 Homo sapiens 30-34 16332249-10 2006 The identification of polyanion-binding sites will help to define the role of FSAP in the vasculature. polyanions 22-31 hyaluronan binding protein 2 Homo sapiens 78-82 16508153-0 2006 Comparison of inhibitory effects of polyanions on nitric oxide production by macrophages stimulated with LPS. polyanions 36-46 interferon regulatory factor 6 Homo sapiens 105-108 16168454-5 2005 Development of resistance to ADS-J1 on the polyanion-resistant HIV-1 led to mutations in gp120 coreceptor binding site and not in gp41. polyanions 43-52 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 89-94 16310517-2 2005 Commercial enzyme immunoassays (EIAs) for PF4/polyanion-reactive antibodies detect two immunoglobulin classes (IgA and IgM) besides IgG. polyanions 46-55 platelet factor 4 Homo sapiens 42-45 16853223-9 2005 The ability of added polyanion to compete with the betaine carboxylic groups in binding with the pyridinium groups was supported by potentiometric titration of PCB-n mixtures with sodium poly(styrenesulfonate): for n > or = 2, the binding of the polyanion-competitor also shifted protonation of carboxylic groups to higher values with DeltapH of more than 2 units. polyanions 21-30 pyruvate carboxylase Homo sapiens 160-163 16853223-9 2005 The ability of added polyanion to compete with the betaine carboxylic groups in binding with the pyridinium groups was supported by potentiometric titration of PCB-n mixtures with sodium poly(styrenesulfonate): for n > or = 2, the binding of the polyanion-competitor also shifted protonation of carboxylic groups to higher values with DeltapH of more than 2 units. polyanions 249-258 pyruvate carboxylase Homo sapiens 160-163 15855160-7 2005 The high degree of similarity between the binding of polyanions and microtubules supports the hypothesis that stable microtubules prevent paired helical filament formation by blocking the tau-polyanion interaction sites, which are crucial for paired helical filament formation. polyanions 53-62 microtubule associated protein tau Homo sapiens 188-191 15894115-2 2005 Although chondroitin sulfate A (CSA), B (CSB) and C (CSC) are highly charged polyanions, little is known about their effects on the proliferation of B cells. polyanions 77-87 excision repair cross-complementing rodent repair deficiency, complementation group 6 Mus musculus 41-44 15855160-6 2005 Chemical shift perturbation studies show that polyanions, which promote paired helical filament aggregation, as well as microtubules interact with tau through positive charges near the ends of the repeats and through the beta-forming motifs at the beginning of repeats 2 and 3. polyanions 46-56 microtubule associated protein tau Homo sapiens 147-150 15855160-7 2005 The high degree of similarity between the binding of polyanions and microtubules supports the hypothesis that stable microtubules prevent paired helical filament formation by blocking the tau-polyanion interaction sites, which are crucial for paired helical filament formation. polyanions 53-63 microtubule associated protein tau Homo sapiens 188-191 15864572-7 2005 However, mixing a polyanion, either poly-aspartate or osteopontin, with the polycation poly-arginine, changed their behavior from disaggregation to aggregation promotion. polyanions 18-27 secreted phosphoprotein 1 Homo sapiens 54-65 15975073-2 2004 The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. polyanions 180-190 microtubule associated protein tau Homo sapiens 16-19 15980594-5 2005 These include: a purification protocol for recombinantly expressed tau; a general method for the polyanion induced polymerization of tau to PHFs; the quantitation of PHFs by a fluorescence-based assay; the imaging and verification of PHFs by negative stain transmission electron microscopy. polyanions 97-106 microtubule associated protein tau Homo sapiens 133-136 15246277-6 2004 We found that the emergence of mutations in gp120 associated with polyanion resistance resulted in a decreased capacity of HIV-1 to bind HSPG. polyanions 66-75 syndecan 2 Homo sapiens 137-141 15246277-7 2004 We also found that the polycation polybrene rescued the capacity of the polyanion-resistant virus to bind HSPG and to infect adherent CD4+ cells. polyanions 72-81 syndecan 2 Homo sapiens 106-110 12236546-2 2002 One of them, pKa value of acidic transition, was shifted from an apparent pKa value 2.5 (typical for cyt c in low ionic strength solvent) to approximately 5.20 +/- 0.15 upon polyanion binding to the protein, pointing to a likely involvement of histidines 26 and/or 33 in the protein acidic transition in complex with the polyanion. polyanions 174-183 cytochrome c, somatic Homo sapiens 101-106 14670592-2 2004 Various polyanions bind to the positively charged V3 loop of gp120. polyanions 8-18 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 61-66 12736188-1 2003 External surfaces of cells are normally protected by extracellular superoxide dismutase, SOD3, which binds to polyanions such as heparan sulfate. polyanions 110-120 superoxide dismutase 3 Rattus norvegicus 89-93 12471127-0 2002 Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H. polyanions 36-46 complement factor H Homo sapiens 131-150 12471127-10 2002 Our results suggest that a region in the most C-terminal domain of FH is involved in target recognition by binding to C3b and surface polyanions. polyanions 134-144 complement factor H Homo sapiens 67-69 12236546-2 2002 One of them, pKa value of acidic transition, was shifted from an apparent pKa value 2.5 (typical for cyt c in low ionic strength solvent) to approximately 5.20 +/- 0.15 upon polyanion binding to the protein, pointing to a likely involvement of histidines 26 and/or 33 in the protein acidic transition in complex with the polyanion. polyanions 321-330 cytochrome c, somatic Homo sapiens 101-106 12236546-5 2002 Polyanion also interacts with chemically-denatured (in the presence of 9 mol/l urea) state of the protein as it follows from stabilization of protein residual structure at acidic pH and its effect on pKa value of acidic transition of chemically-denatured cyt c. polyanions 0-9 cytochrome c, somatic Homo sapiens 255-260 11851332-10 2002 As the remaining FH substitutions could also be correlated with their proximity to conserved basic residues, haemolytic uraemic syndrome may result from a failure of FH to interact with polyanions at cell surfaces in the kidney. polyanions 186-196 complement factor H Homo sapiens 166-168 11135081-5 2001 The binding characteristics of IgA1 to HMCs in the presence of polycation (poly-L-lysine) or polyanion (heparin) were also investigated. polyanions 93-102 immunoglobulin heavy constant alpha 1 Homo sapiens 31-35 11206188-2 2001 Three chemical modifications of rat serum albumin (RSA) were effected on the amine groups of this protein: conjugation with a polyanion using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, intermolecular cross-linking using glutaraldehyde, and reductive alkylation using propyl aldehyde. polyanions 126-135 albumin Homo sapiens 36-49 11433225-6 2001 The findings support the view that antibodies associated with HIT are specific for conformational changes that take place in the positively charged PF4 molecule when it reacts with a suitable, linear polyanion. polyanions 200-209 platelet factor 4 Homo sapiens 148-151 11135081-5 2001 The binding characteristics of IgA1 to HMCs in the presence of polycation (poly-L-lysine) or polyanion (heparin) were also investigated. polyanions 93-102 MKKS centrosomal shuttling protein Homo sapiens 39-43 11135081-20 2001 Preincubation with polyanion decreased the binding of polymeric IgA to HMCs. polyanions 19-28 MKKS centrosomal shuttling protein Homo sapiens 71-75 10644368-4 2000 Here we demonstrate by monoclonal-antibody inhibition, labeled heparin binding, and surface plasmon resonance studies that a second site, most probably corresponding to the newly defined, highly conserved coreceptor binding region on gp120, forms part of the polyanion binding surface. polyanions 259-268 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 234-239 10964417-2 2000 Studies have shown that the efficiency of the binding depends on the presence of the V3 loop of the gp120 which is known to interact with polyanions, such as phosphorothioate oligodeoxynucleotides (Sd, potential anti-HIV drugs). polyanions 138-148 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 100-105 10644368-1 2000 It is well established that the gp120 V3 loop of T-cell-line-adapted human immunodeficiency virus type 1 (HIV-1) binds both cell-associated and soluble polyanions. polyanions 152-162 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 32-37 10644368-5 2000 Consistent with the binding of polyanions to the coreceptor binding surface, dextran sulfate interfered with the gp120-CXCR4 association while having no detectable effect on the gp120-CD4 interaction. polyanions 31-41 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 113-118 10644368-3 2000 However, the analysis of gp120-polyanion interactions has been limited to T-cell-line-adapted, CXCR4-using virus and virus-derived gp120, and the polyanion binding ability of gp120 regions other than the V3 loop has not been addressed. polyanions 31-40 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 25-30 10644368-5 2000 Consistent with the binding of polyanions to the coreceptor binding surface, dextran sulfate interfered with the gp120-CXCR4 association while having no detectable effect on the gp120-CD4 interaction. polyanions 31-41 C-X-C motif chemokine receptor 4 Homo sapiens 119-124 10644368-7 2000 Analysis of mutated forms of X4 gp120 demonstrated that the V3 loop is the major determinant for polyanion binding whereas other regions, including the V1/V2 loop structure and the NH(2) and COOH termini, exert a more subtle influence. polyanions 97-106 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 32-37 10644368-9 2000 These results demonstrate a selective interaction of gp120 with polyanions and suggest that the conserved coreceptor binding surface may present a novel and conserved target for therapeutic intervention. polyanions 64-74 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 53-58 10620613-5 2000 Type I and II class A scavenger receptors (SR-AI/II) recognize a variety of polyanions including bacterial cell wall products such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), suggesting a role for SR-AI/II in innate immunity to bacterial infections. polyanions 76-86 macrophage scavenger receptor 1 Mus musculus 43-48 10620613-5 2000 Type I and II class A scavenger receptors (SR-AI/II) recognize a variety of polyanions including bacterial cell wall products such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), suggesting a role for SR-AI/II in innate immunity to bacterial infections. polyanions 76-86 macrophage scavenger receptor 1 Mus musculus 210-215 11710195-2 2000 Here PA1 and PA2 are two different states or structural forms of a polyanion, B1 and B2 are the number of M+ ions thermodynamically bound to the polyanions PA1 and PA2, respectively. polyanions 67-76 PAXIP1 associated glutamate rich protein 1 Homo sapiens 5-8 11710195-2 2000 Here PA1 and PA2 are two different states or structural forms of a polyanion, B1 and B2 are the number of M+ ions thermodynamically bound to the polyanions PA1 and PA2, respectively. polyanions 67-76 PAXIP1 associated glutamate rich protein 1 Homo sapiens 156-159 11710195-2 2000 Here PA1 and PA2 are two different states or structural forms of a polyanion, B1 and B2 are the number of M+ ions thermodynamically bound to the polyanions PA1 and PA2, respectively. polyanions 145-155 PAXIP1 associated glutamate rich protein 1 Homo sapiens 5-8 11710195-2 2000 Here PA1 and PA2 are two different states or structural forms of a polyanion, B1 and B2 are the number of M+ ions thermodynamically bound to the polyanions PA1 and PA2, respectively. polyanions 145-155 PAXIP1 associated glutamate rich protein 1 Homo sapiens 156-159 10209287-0 1999 Amino acid residues of heparin cofactor II required for stimulation of thrombin inhibition by sulphated polyanions. polyanions 104-114 serpin family D member 1 Homo sapiens 23-42 10525152-1 1999 The effect of polyanion, poly(vinylsulfate), used as a model of negatively charged surface, on ferric cytochrome c (ferricyt c) structure in acidic pH has been studied by absorbance spectroscopy, circular dichroism (CD), tryptophan (Trp) fluorescence and microcalorimetry. polyanions 14-23 cytochrome c, somatic Homo sapiens 102-114 10477271-1 1999 Certain polysulphated polyanions have been shown to have prophylactic effects on the progression of transmissible spongiform encephalopathy disease, presumably because they bind to prion protein (PrP). polyanions 22-32 prion protein Mus musculus 196-199 10477271-8 1999 The differences in the binding strengths of recPrP to pentosan polysulphate and to other sulphated polyanions were found to parallel their in vivo anti-scrapie and in vitro anti-scrapie-specific PrP formation potencies. polyanions 99-109 prion protein Mus musculus 47-50 10209287-3 1999 In this study we determined the concentrations (IC50) of various polyanions required to stimulate thrombin inhibition by native recombinant HCII in comparison with three recombinant HCII variants having decreased affinity for heparin (Lys-173-->Gln), dermatan sulphate (Arg-189-->His), or both heparin and dermatan sulphate (Lys-185-->Asn). polyanions 65-75 serpin family D member 1 Homo sapiens 140-144 10209287-8 1999 These results suggest that, like dermatan sulphate and heparin, other polyanions stimulate HCII primarily by an allosteric mechanism requiring the N-terminal acidic domain. polyanions 70-80 serpin family D member 1 Homo sapiens 91-95 10209287-0 1999 Amino acid residues of heparin cofactor II required for stimulation of thrombin inhibition by sulphated polyanions. polyanions 104-114 coagulation factor II, thrombin Homo sapiens 71-79 10209287-1 1999 A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). polyanions 23-33 coagulation factor II, thrombin Homo sapiens 107-115 10209287-1 1999 A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). polyanions 23-33 serpin family D member 1 Homo sapiens 119-138 10209287-1 1999 A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). polyanions 23-33 serpin family D member 1 Homo sapiens 140-144 10209287-3 1999 In this study we determined the concentrations (IC50) of various polyanions required to stimulate thrombin inhibition by native recombinant HCII in comparison with three recombinant HCII variants having decreased affinity for heparin (Lys-173-->Gln), dermatan sulphate (Arg-189-->His), or both heparin and dermatan sulphate (Lys-185-->Asn). polyanions 65-75 coagulation factor II, thrombin Homo sapiens 98-106 10233845-5 1999 Although the glomerular polyanion was greatly reduced in proteinuric Mpv17-/- mice, it was preserved by antioxidative therapy. polyanions 24-33 MpV17 mitochondrial inner membrane protein Mus musculus 69-74 9692954-3 1998 We have used affinity chromatography and ultrafiltration to probe for direct binding of PEDF to glycosaminoglycans/polyanions. polyanions 115-125 serpin family F member 1 Homo sapiens 88-92 9759973-0 1998 Direct activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion. polyanions 97-106 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 25-67 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. polyanions 8-18 coagulation factor II, thrombin Homo sapiens 127-135 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. polyanions 8-18 fibrinogen beta chain Homo sapiens 158-168 9699464-0 1998 Coulombic and noncoulombic effect of polyanions on cytochrome c structure. polyanions 37-47 cytochrome c, somatic Homo sapiens 51-63 9699464-3 1998 The addition of the second polyanion to a solution of ferric cytochrome c at a low ionic strength, pH 7.0, resulted in profound conformational change in the hydrophobic core of protein (opening of the heme crevice with a perturbation of the methionine 80-heme iron bond and the hydrophobic core of the protein). polyanions 27-36 cytochrome c, somatic Homo sapiens 61-73 9295359-4 1997 Polyanions such as polyglutamate and double-stranded and single-stranded DNA bind to Cdc14p and affect its activity. polyanions 0-10 phosphoprotein phosphatase CDC14 Saccharomyces cerevisiae S288C 85-91 9664623-4 1998 In this study, the uncoupling agents GTP gamma S and pentosan sulfate (PS) (a low molecular weight polyanion) were used to further characterize the molecular interactions between Ang II analogs and the AT1 receptor. polyanions 99-108 angiotensin II receptor type 1 Homo sapiens 202-205 9058241-2 1997 The principle is as follows: low density lipoproteins (LDL) and very low density lipoproteins (VLDL) were coated by polymers and polyanion to be blocked from cholesterol esterase and cholesterol oxidase. polyanions 129-138 carboxyl ester lipase Homo sapiens 158-178 8853808-7 1996 Synthetic polyanion compounds were used as the affinity ligands for LDL adsorbent to simulate the anion-rich sequence of LDL binding sites in the human LDL receptor. polyanions 10-19 low density lipoprotein receptor Homo sapiens 152-164 9118233-0 1996 Polyanion induced preferential multinucleation in macrophages at a low level of TNF-alpha secretion. polyanions 0-9 tumor necrosis factor Rattus norvegicus 80-89 9012864-1 1996 Phosphorothioate oligodeoxynucleotides belong to a class of polyanions that bind to the third variable domain (v3) of HIV-1 gp120 and inhibit infectivity of a wide variety of HIV-1 isolates. polyanions 60-70 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 124-129 8843338-2 1996 Tripolyphosphate, a model compound for polyanions, decreased the Km value of porcine cathepsin D for bovine serum albumin without affecting VMAX. polyanions 39-49 cathepsin D Homo sapiens 85-96 7543282-10 1995 In contrast to heparin, a polyanion which stabilizes the native structure of aFGF, negatively charged phospholipid membranes appear to enhance the disruption of aFGF tertiary structure at submicellar concentrations of sodium dodecyl sulfate but stabilize the remaining secondary structure. polyanions 26-35 fibroblast growth factor 1 Homo sapiens 77-81 7481560-4 1995 In factor H the polyanion recognition site participates in the discrimination between alternative pathway activating and non-activating surfaces. polyanions 16-25 complement factor H Homo sapiens 3-11 8528192-3 1995 ELISA for TNF-alpha showed that the polyanion induced TNF-alpha production by macrophages. polyanions 36-45 tumor necrosis factor Rattus norvegicus 10-19 8528192-3 1995 ELISA for TNF-alpha showed that the polyanion induced TNF-alpha production by macrophages. polyanions 36-45 tumor necrosis factor Rattus norvegicus 54-63 8172562-7 1993 The complex formation of C1q, the most basic serum protein, with this polyanion was demonstrated by several methods: agarose gel electrophoresis followed by immunoprecipitation in the gel and Coomassie staining; western blot analysis of C1q-PRP complexes; complex formation in electrophoretic separation of PRP; retardation of electrophoretic mobility of PRP was checked by blotting of this polysaccharide. polyanions 70-79 complement C1q A chain Homo sapiens 25-28 7786411-2 1995 In this report, we find that the TPKI/GSK-3 beta/FA can be stimulated to phosphorylate brain tau up to 8.5 mol of phosphates per mol of protein by heparin, a polyanion compound. polyanions 158-167 glycogen synthase kinase 3 alpha Homo sapiens 38-48 7786411-2 1995 In this report, we find that the TPKI/GSK-3 beta/FA can be stimulated to phosphorylate brain tau up to 8.5 mol of phosphates per mol of protein by heparin, a polyanion compound. polyanions 158-167 microtubule associated protein tau Homo sapiens 93-96 7536241-0 1995 Deamidation of polyanion-stabilized acidic fibroblast growth factor. polyanions 15-24 fibroblast growth factor 1 Homo sapiens 36-67 7536241-1 1995 The deamidation of polyanion-stabilized acidic fibroblast growth factor (aFGF; FGF-1) can be induced by prolonged storage under accelerated conditions of elevated pH and temperature. polyanions 19-28 fibroblast growth factor 1 Homo sapiens 40-71 7536241-1 1995 The deamidation of polyanion-stabilized acidic fibroblast growth factor (aFGF; FGF-1) can be induced by prolonged storage under accelerated conditions of elevated pH and temperature. polyanions 19-28 fibroblast growth factor 1 Homo sapiens 73-77 7536241-1 1995 The deamidation of polyanion-stabilized acidic fibroblast growth factor (aFGF; FGF-1) can be induced by prolonged storage under accelerated conditions of elevated pH and temperature. polyanions 19-28 fibroblast growth factor 1 Homo sapiens 79-84 7868983-1 1994 Lipoprotein lipase (LPL) interaction with membrane-associated polyanions is a critical component of normal catalytic function. polyanions 62-72 lipoprotein lipase Homo sapiens 0-18 7868983-1 1994 Lipoprotein lipase (LPL) interaction with membrane-associated polyanions is a critical component of normal catalytic function. polyanions 62-72 lipoprotein lipase Homo sapiens 20-23 7829123-9 1994 These results provide some more insight in the behavior of CD4 on lymphoid cell surfaces in response to high molecular weight polyanions such as dextran sulfate. polyanions 126-136 CD4 molecule Homo sapiens 59-62 7521897-0 1994 Sulfated polyanions prevent HIV infection of lymphocytes by disruption of the CD4-gp120 interaction, but do not inhibit monocyte infection. polyanions 9-19 CD4 molecule Homo sapiens 78-81 7521897-0 1994 Sulfated polyanions prevent HIV infection of lymphocytes by disruption of the CD4-gp120 interaction, but do not inhibit monocyte infection. polyanions 9-19 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 82-87 7521897-1 1994 Sulfated polyanions (SPs) bind variably to lymphocyte-expressed CD4 and inhibit binding of monoclonal antibodies to the first two domains of CD4. polyanions 9-19 CD4 molecule Homo sapiens 64-67 7521897-1 1994 Sulfated polyanions (SPs) bind variably to lymphocyte-expressed CD4 and inhibit binding of monoclonal antibodies to the first two domains of CD4. polyanions 9-19 CD4 molecule Homo sapiens 141-144 8030949-5 1994 The relative potencies of the sulfated glycans corresponded with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulfated polyanions may be due to inhibition of protease-resistant PrP accumulation. polyanions 179-189 prion protein Homo sapiens 237-240 7913757-5 1994 The relative potencies of various sulphated glycans correlate with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulphated polyanions is due to inhibition of protease-resistant PrP accumulation. polyanions 182-192 prion protein Homo sapiens 236-239 8292049-0 1994 Regulation of alternative pathway complement activation by glycosaminoglycans: specificity of the polyanion binding site on factor H. polyanions 98-107 complement factor H Homo sapiens 124-132 8292049-3 1994 In this study we have analyzed the ability of different glycosaminoglycans and other negatively charged macromolecules to interact with the factor H polyanion recognition site and to enhance binding of H to the C3b-target complex. polyanions 149-158 complement factor H Homo sapiens 140-148 8292049-9 1994 The results show that the interaction of the polyanion binding site on factor H with glycosaminoglycans depends upon the number, orientation and polymeric arrangement of sulphate groups and suggest that most, but not all, sulphated glycosaminoglycans participate in the protection of host tissues from complement damage by promoting inactivation of tissue-bound C3b. polyanions 45-54 complement factor H Homo sapiens 71-79 8292049-9 1994 The results show that the interaction of the polyanion binding site on factor H with glycosaminoglycans depends upon the number, orientation and polymeric arrangement of sulphate groups and suggest that most, but not all, sulphated glycosaminoglycans participate in the protection of host tissues from complement damage by promoting inactivation of tissue-bound C3b. polyanions 45-54 endogenous retrovirus group K member 3 Homo sapiens 362-365 9815893-11 1995 The interactions of polyanions with PKC are complex, and are dependent on the molecular structure of the polyanion, the presence of cofactors, and the PKC isoform. polyanions 20-29 protein kinase C alpha Homo sapiens 36-39 9815893-11 1995 The interactions of polyanions with PKC are complex, and are dependent on the molecular structure of the polyanion, the presence of cofactors, and the PKC isoform. polyanions 20-29 protein kinase C alpha Homo sapiens 151-154 7521897-5 1994 Recombinant gp120 bound poorly (< 10%) to all of the immobilized polyanions, except pentosan sulfate (17%), for which some binding was noted. polyanions 68-78 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 12-17 7516183-8 1994 On the basis of the crystal structure of bovine aFGF, eight of the prospective labeled sites appear to be dispersed around the perimeter of the growth factor"s presumptive polyanion binding site. polyanions 172-181 fibroblast growth factor 1 Bos taurus 48-52 7516183-12 1994 In conclusion, nucleotides bind apparently nonspecifically to the polyanion binding site of aFGF but nevertheless are capable of modulating the protein"s activity. polyanions 66-75 fibroblast growth factor 1 Bos taurus 92-96 7516183-13 1994 Evidence for the presence of a second or more extended polyanion binding site and the potential biological significance of these results in terms of potential natural ligands of aFGF are also discussed but not resolved. polyanions 55-64 fibroblast growth factor 1 Bos taurus 178-182 8311468-8 1994 Automodification of the transferase decreased polyanion-induced ADP-ribosylation of p33. polyanions 46-55 leukocyte cell derived chemotaxin 2 Gallus gallus 84-87 8172562-7 1993 The complex formation of C1q, the most basic serum protein, with this polyanion was demonstrated by several methods: agarose gel electrophoresis followed by immunoprecipitation in the gel and Coomassie staining; western blot analysis of C1q-PRP complexes; complex formation in electrophoretic separation of PRP; retardation of electrophoretic mobility of PRP was checked by blotting of this polysaccharide. polyanions 70-79 complement C1q A chain Homo sapiens 237-240 8172565-6 1993 Moreover, membrane C1q appears to be involved in various cellular events such as binding of Fc, polyanions, lipid A and gram-negative bacteria to macrophages. polyanions 96-106 complement C1q A chain Homo sapiens 19-22 7692970-8 1993 SOS competes with heparin and suramin for the aFGF polyanion binding site as measured by both fluorescence and light scattering based competitive binding assays. polyanions 51-60 fibroblast growth factor 1 Homo sapiens 46-50 7692970-11 1993 Thus, due to their high charge density, SOS and sucralfate bind and stabilize aFGF via interaction with the aFGF polyanion binding site. polyanions 113-122 fibroblast growth factor 1 Homo sapiens 78-82 7692970-11 1993 Thus, due to their high charge density, SOS and sucralfate bind and stabilize aFGF via interaction with the aFGF polyanion binding site. polyanions 113-122 fibroblast growth factor 1 Homo sapiens 108-112 7691835-6 1993 The ability to potentiate the neurotrophic action of aFGF for E8 chick ciliary neurons was a general property of those PA with low or no activity in the mitogen assay. polyanions 119-121 fibroblast growth factor 1 Gallus gallus 53-57 7692842-9 1993 DNA or heparin (another polyanion) activated tyrosine hydroxylase and decreased fluorescence of the reporter group 30% at pH 6.0. polyanions 24-33 tyrosine hydroxylase Rattus norvegicus 45-65 7692842-12 1993 These results suggest that polyanions play a minimal role, if any, in the physiological regulation of tyrosine hydroxylase activity. polyanions 27-37 tyrosine hydroxylase Rattus norvegicus 102-122 7691835-0 1993 Investigation of the ability of several naturally occurring and synthetic polyanions to bind to and potentiate the biological activity of acidic fibroblast growth factor. polyanions 74-84 fibroblast growth factor 1 Mus musculus 138-169 7691835-8 1993 The differential effects of these PA in potentiating the biological activities of aFGF are discussed in relation to their ability to compete for the heparin-binding site of aFGF. polyanions 34-36 fibroblast growth factor 1 Mus musculus 82-86 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 60-70 fibroblast growth factor 1 Mus musculus 145-176 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 60-70 fibroblast growth factor 1 Mus musculus 178-182 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 72-75 fibroblast growth factor 1 Mus musculus 145-176 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 72-75 fibroblast growth factor 1 Mus musculus 178-182 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 98-101 fibroblast growth factor 1 Mus musculus 145-176 7691835-1 1993 The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. polyanions 98-101 fibroblast growth factor 1 Mus musculus 178-182 7691835-8 1993 The differential effects of these PA in potentiating the biological activities of aFGF are discussed in relation to their ability to compete for the heparin-binding site of aFGF. polyanions 34-36 fibroblast growth factor 1 Mus musculus 173-177 7686672-3 1993 It was found that in addition to the well-known protection of aFGF by heparin, a surprisingly wide variety of polyanions (including small sulfated and phosphorylated compounds) also stabilizes aFGF. polyanions 110-120 fibroblast growth factor 1 Mus musculus 193-197 8336081-4 1993 A role for a specific proteinase, human neutrophil elastase (HNE), is supported by the facts that (1) asbestos increased HNE release assessed by an enzyme-linked immunosorbent assay technique (1.7 +/- 0.5 vs. 2.8 +/- 0.5 micrograms/ml; P < .025), (2) purified HNE or porcine pancreatic elastase (PPE) each alone caused PEC detachment, (3) asbestos plus either HNE or PPE caused PEC lysis similar to that mediated by asbestos and PMNs, and (4) cationic agents released from PMNs were unlikely to be involved because polyanions did not ameliorate injury resulting from asbestos and PMNs. polyanions 518-528 elastase, neutrophil expressed Homo sapiens 40-59 7686045-0 1993 Effect of polyanions on the unfolding of acidic fibroblast growth factor. polyanions 10-20 fibroblast growth factor 1 Homo sapiens 41-72 7686045-2 1993 In the absence of a stabilizing polyanion, the apparent free energy of unfolding of aFGF is 6.5 kcal mol-1. polyanions 32-41 fibroblast growth factor 1 Homo sapiens 84-88 7686045-6 1993 Additional experiments demonstrate that increasing charge density enhances the ability of polyanions such as sulfated beta-cyclodextrins, phosphorylated inositols, and modified heparins to protect aFGF from urea-induced unfolding. polyanions 90-100 fibroblast growth factor 1 Homo sapiens 197-201 7511269-6 1993 Growth stimulation of LNCaP cells by EGF/TGF alpha can be completely reversed by simultaneous addition of polyanions but they inhibit androgen stimulation only partially. polyanions 106-116 transforming growth factor alpha Homo sapiens 41-50 7678300-0 1993 Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. polyanions 9-18 prion protein Homo sapiens 52-55 7678726-0 1993 Physical stabilization of acidic fibroblast growth factor by polyanions. polyanions 61-71 fibroblast growth factor 1 Homo sapiens 26-57 7678726-2 1993 Partially due to the heterogeneity of heparin preparations, the nature of the aFGF polyanion binding site is still ill-defined. polyanions 83-92 fibroblast growth factor 1 Homo sapiens 78-82 7678726-3 1993 We have, therefore, investigated a wide variety of well-defined polyanions in terms of their ability to stabilize human recombinant aFGF (15-154) against thermal denaturation. polyanions 64-74 fibroblast growth factor 1 Homo sapiens 132-136 7678726-4 1993 The specificity of the interaction between aFGF and polyanions is shown to be remarkably weak with a surprising number of polyanions (including small phosphorylated and sulfated compounds as well as highly charged biopolymers) able to induce physical stability. polyanions 52-62 fibroblast growth factor 1 Homo sapiens 43-47 7678726-4 1993 The specificity of the interaction between aFGF and polyanions is shown to be remarkably weak with a surprising number of polyanions (including small phosphorylated and sulfated compounds as well as highly charged biopolymers) able to induce physical stability. polyanions 122-132 fibroblast growth factor 1 Homo sapiens 43-47 1282813-1 1992 The formed complexes of cytochrome c with polyanions retain the bond of Met-80 with heme iron. polyanions 42-52 cytochrome c, somatic Homo sapiens 24-36 1390688-3 1992 This interaction stabilizes aFGF to thermal denaturation and partially protects a free thiol in its polyanion binding site from oxidation. polyanions 100-109 fibroblast growth factor 1 Homo sapiens 28-32 1382654-7 1992 Although theta for Ficoll at rs = 35 A was much smaller than the corresponding value for dextran, it was still approximately 30 times greater than typical values of the filtrate-to-plasma concentration ratio reported for serum albumin (a polyanion) in the rat, in agreement with the concept that glomerular charge-selectivity normally plays an important role in the prevention of albuminuria. polyanions 238-247 albumin Rattus norvegicus 221-234 1298716-6 1992 Electron-dense particles formed by binding of protamine to polyanions were seen primarily in the lamina rara externa of glomerular basement membrane and also along the lamina rara interna and on the foot process surface, which showed the distribution feature of glomerular filter. polyanions 59-69 retinoic acid receptor, alpha Rattus norvegicus 104-108 1499567-2 1992 Recently we have shown that heparin and related sulfated polyanions are low-affinity ligands of the kringle domain in the amino-terminal region (ATF) of human urokinase (u-PA), and proposed that this may facilitate loading of u-PA onto its receptor at the focal contacts between adherent cells and their matrix. polyanions 57-67 glial cell derived neurotrophic factor Homo sapiens 145-148 1499567-2 1992 Recently we have shown that heparin and related sulfated polyanions are low-affinity ligands of the kringle domain in the amino-terminal region (ATF) of human urokinase (u-PA), and proposed that this may facilitate loading of u-PA onto its receptor at the focal contacts between adherent cells and their matrix. polyanions 57-67 plasminogen activator, urokinase Homo sapiens 170-174 1499567-2 1992 Recently we have shown that heparin and related sulfated polyanions are low-affinity ligands of the kringle domain in the amino-terminal region (ATF) of human urokinase (u-PA), and proposed that this may facilitate loading of u-PA onto its receptor at the focal contacts between adherent cells and their matrix. polyanions 57-67 plasminogen activator, urokinase Homo sapiens 226-230 1569928-15 1992 Direct interaction of polyanions with AT1 was suggested by the capacity of solubilized photoaffinity-labeled 125I-AT1 to adsorb to heparin-agarose gels. polyanions 22-32 angiotensin II receptor type 1 Bos taurus 38-41 1315738-6 1992 Non-sulfated and non-carboxylated polyanions also enhanced proteinase inhibition by protein C inhibitor. polyanions 34-44 endogenous retrovirus group K member 18 Homo sapiens 59-69 1315738-6 1992 Non-sulfated and non-carboxylated polyanions also enhanced proteinase inhibition by protein C inhibitor. polyanions 34-44 serpin family A member 5 Homo sapiens 84-103 1569928-15 1992 Direct interaction of polyanions with AT1 was suggested by the capacity of solubilized photoaffinity-labeled 125I-AT1 to adsorb to heparin-agarose gels. polyanions 22-32 angiotensin II receptor type 1 Bos taurus 114-117 1769968-14 1991 The mono(ADP-ribosyl)ation of p33 was markedly enhanced by polyanion, such as DNA, RNA, or poly(L-glutamate). polyanions 59-68 leukocyte cell derived chemotaxin 2 Gallus gallus 30-33 1917988-2 1991 We have found that heparin and other polyanions compete with photoactivated, phosphorylated rhodopsin to bind arrestin (48-kDa protein, S-antigen). polyanions 37-47 S-antigen visual arrestin Bos taurus 120-134 1748468-0 1991 Conservation of a polyanion binding site in mammalian and avian CD4. polyanions 18-27 CD4 molecule Homo sapiens 64-67 1748468-1 1991 A polyanion binding site was identified recently on human CD4 which is distinct from the human immunodeficiency virus (HIV)-gp120 binding region but which incorporates the first two immunoglobulin (Ig)-like domains of the molecule. polyanions 2-11 CD4 molecule Homo sapiens 58-61 1748468-5 1991 The polyanions did not inhibit mAb binding to a variety of other cell-surface antigens in the different species, with the exception of sheep CD8, suggesting that the inhibitory effects observed were essentially CD4 specific. polyanions 4-14 T-cell surface glycoprotein CD4 Ovis aries 211-214 1748468-6 1991 Collectively these data indicate that a polyanion binding site is conserved in mammalian and avian CD4. polyanions 40-49 CD4 molecule Homo sapiens 99-102 1748468-7 1991 Comparison of the amino acid sequences of human, mouse and rat CD4 revealed that basic residues in human CD4 which could participate in a polyanion binding site are conserved in mouse and rat CD4. polyanions 138-147 Cd4 molecule Rattus norvegicus 63-66 1748468-7 1991 Comparison of the amino acid sequences of human, mouse and rat CD4 revealed that basic residues in human CD4 which could participate in a polyanion binding site are conserved in mouse and rat CD4. polyanions 138-147 CD4 molecule Homo sapiens 105-108 1748468-7 1991 Comparison of the amino acid sequences of human, mouse and rat CD4 revealed that basic residues in human CD4 which could participate in a polyanion binding site are conserved in mouse and rat CD4. polyanions 138-147 Cd4 molecule Rattus norvegicus 105-108 1748468-8 1991 It is proposed that this conserved polyanion binding site of CD4 interacts with a sulphated glycosaminoglycan chain which is associated with class II major histocompatibility complex (MHC) molecules containing recently processed antigen. polyanions 35-44 CD4 molecule Homo sapiens 61-64 1721051-0 1991 Effect of polyanions on the refolding of human acidic fibroblast growth factor. polyanions 10-20 fibroblast growth factor 1 Homo sapiens 47-78 1721051-1 1991 Acidic fibroblast growth factor (aFGF) is unstable at physiological temperatures in the absence of polyanions such as heparin. polyanions 99-109 fibroblast growth factor 1 Homo sapiens 33-37 1692629-0 1990 Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. polyanions 123-132 complement factor H Homo sapiens 149-157 1839080-7 1991 The effect of protamine on plasmin clearance suggests that an unknown plasmin inhibitor may be produced by rhabdomyosarcoma cells, whose action is accelerated by endogenous polyanions, in an analogous manner to thrombin inactivation by antithrombin III and protease nexin on endothelial cells and fibroblasts, respectively. polyanions 173-183 plasminogen Homo sapiens 70-77 1759905-2 1991 Several polyanions (mucin, heparin, polygalacturonic acid) and polycations (polylysine, protamine, polybrene) were able to reduce the replication of SNV when present in the viral adsorption period, whereas others (chondroitin sulfate, polymyxin B sulfate, histone) were devoid of any activity. polyanions 8-18 LOC100508689 Homo sapiens 20-25 1700081-0 1990 Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions. polyanions 102-112 agrin Homo sapiens 14-19 1700081-4 1990 Inhibition of agrin-induced AChR aggregation was due, at least in part, to the formation of a complex between the polyanion and agrin that was inactive. polyanions 114-123 agrin Homo sapiens 14-19 1700081-4 1990 Inhibition of agrin-induced AChR aggregation was due, at least in part, to the formation of a complex between the polyanion and agrin that was inactive. polyanions 114-123 agrin Homo sapiens 128-133 2169306-0 1990 Polyanion binding to cytochrome c probed by resonance Raman spectroscopy. polyanions 0-9 cytochrome c, somatic Homo sapiens 21-33 2380554-0 1990 A polyanion binding site on the CD4 molecule. polyanions 2-11 CD4 molecule Homo sapiens 32-35 1692629-4 1990 Fluid-phase polyanions enhanced binding of factor H to C3b attached to activating particles, indicating that the effect resulted from increased affinity between C3b and factor H. polyanions 12-22 complement factor H Homo sapiens 43-51 1692629-4 1990 Fluid-phase polyanions enhanced binding of factor H to C3b attached to activating particles, indicating that the effect resulted from increased affinity between C3b and factor H. polyanions 12-22 endogenous retrovirus group K member 3 Homo sapiens 55-58 1692629-4 1990 Fluid-phase polyanions enhanced binding of factor H to C3b attached to activating particles, indicating that the effect resulted from increased affinity between C3b and factor H. polyanions 12-22 endogenous retrovirus group K member 3 Homo sapiens 161-177 1692629-9 1990 These observations suggest that occupation of a specific site on factor H by polyanions induces an increase in the C3b-H affinity, resulting in discrimination of host cells and tissues from alternative pathway-activating foreign cells. polyanions 77-87 complement factor H Homo sapiens 65-73 1692629-9 1990 These observations suggest that occupation of a specific site on factor H by polyanions induces an increase in the C3b-H affinity, resulting in discrimination of host cells and tissues from alternative pathway-activating foreign cells. polyanions 77-87 endogenous retrovirus group K member 3 Homo sapiens 115-118 35263420-4 2022 51% of patients using the Stago assay had a persistently positive anti-PF4/polyanion levels 100 days post diagnosis whilst 94% of patients monitored using the Immucor assay remain positive. polyanions 75-84 platelet factor 4 Homo sapiens 71-74 11502203-7 2001 The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues. polyanions 63-73 plasminogen activator, urokinase Homo sapiens 56-59 11502203-7 2001 The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues. polyanions 63-73 plasminogen activator, urokinase Homo sapiens 100-103 11502203-7 2001 The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues. polyanions 63-72 plasminogen activator, urokinase Homo sapiens 56-59 11502203-7 2001 The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues. polyanions 63-72 plasminogen activator, urokinase Homo sapiens 100-103 34815130-7 2022 Docking studies revealed it has an unprecedented extended binding to the polyanion-binding site of IDE. polyanions 73-82 insulin degrading enzyme Homo sapiens 99-102 34062235-3 2021 RESULTS: A hybrid nanocarrier composed of calcium phosphate as the inorganic phase and a block copolymer containing polyanions as organic phase, named HNPs, was developed to deliver VEGF siRNA into metastatic breast cancer in mice. polyanions 116-126 vascular endothelial growth factor A Mus musculus 182-186 34484238-2 2021 Vaccine-induced immune thrombotic thrombocytopenia (VITT) is characterized by high levels of serum IgG that bind PF4/polyanion complexes, thus triggering platelet activation. polyanions 117-126 platelet factor 4 Homo sapiens 113-116 35132672-5 2022 Most Ad26.COV2.S-associated VITT antibodies persisted for >5 months in PF4-polyanion ELISAs, while the PEA became negative earlier. polyanions 75-84 platelet factor 4 Homo sapiens 71-74 34912330-17 2021 Recent studies have assumed a mechanism that is assimilable to heparin-induced thrombocytopenia, with protagonist antibodies against the PF4-polyanion complex. polyanions 141-150 platelet factor 4 Homo sapiens 137-140 34474475-4 2021 Consequently, we set out to determine whether the capacity of HRG to bind polyanions enables it to regulate polyP-induced thrombosis. polyanions 74-84 histidine-rich glycoprotein Mus musculus 62-65 34526009-3 2021 Platelet factor 4 is a naturally occurring chemokine, and under certain conditions, may complex with negatively charged molecules and polyanions, including heparin. polyanions 134-144 platelet factor 4 Homo sapiens 0-17 34312301-9 2021 Screening for presence of heparin-induced thrombocytopenia-related antibodies was positive, and highly elevated serum IgG antibodies against PF4-polyanion complexes were subsequently proven. polyanions 145-154 platelet factor 4 Homo sapiens 141-144 2737700-3 1989 Polyanions inhibited ADCC mediated by either IgG2a or IgG2b in a reversible manner. polyanions 0-10 immunoglobulin heavy variable V1-9 Mus musculus 45-50 35448141-2 2022 A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontaneous interactions between CS and natural or synthetic biocompatible polyanions. polyanions 221-231 citrate synthase Homo sapiens 179-181 35457009-6 2022 In vitro recombinant tau can be aggregated by the action of polyanions, such as heparin, arachidonic acid, and more recently, the action of polyphosphates. polyanions 60-70 microtubule associated protein tau Homo sapiens 21-24 2552144-6 1989 In addition, the BHLF1 protein is exhibiting polyanion-binding activity with a maximum for single-stranded DNA. polyanions 45-54 protein BHLF1 Human gammaherpesvirus 4 17-22 2737700-3 1989 Polyanions inhibited ADCC mediated by either IgG2a or IgG2b in a reversible manner. polyanions 0-10 immunoglobulin heavy constant gamma 2B Mus musculus 54-59 2744005-9 1989 It is concluded that 1) podocalyxin is synthesized at a high rate in the differentiating podocyte; 2) its distribution is restricted to the apical plus lateral plasmalemmal domain facing the urinary spaces above the migrating junctions; 3) its time of appearance and distribution during glomerular development are identical to that reported earlier for epithelial polyanion; and 4) its synthesis and insertion into the podocyte plasmalemma is closely coupled to the development of the foot processes and filtration slits. polyanions 364-373 podocalyxin-like Rattus norvegicus 24-35 2465366-10 1989 We speculate that the proteolysis of apoB-100 induced by DS is not limited to this polyanion, but may also be the property of other negatively charged agents, particularly at cold temperatures. polyanions 83-92 apolipoprotein B Homo sapiens 37-45 2459119-12 1988 By using this method, PLC-I, PLC-II, and PLC-III could be measured quantitatively in the presence of other proteins, detergents, lipids, polyanions, and metal ions, all of which greatly affect the activity of PLC enzymes. polyanions 137-147 phospholipase C beta 1 Bos taurus 22-27 3196724-9 1988 It is suggested that the initial uptake of lipoprotein lipase occurs by binding to a polyanion at the liver cell surface. polyanions 85-94 lipoprotein lipase Rattus norvegicus 43-61 2461602-4 1988 These results suggest that t-PA and plasminogen preferentially bind to sulfated or carboxylated polyanions, which may be required to possess certain neutral groups, and such complex formation may improve the plasminogen activation kinetics in a different manner from that of fibrin. polyanions 96-106 plasminogen activator, tissue type Homo sapiens 27-31 2459119-12 1988 By using this method, PLC-I, PLC-II, and PLC-III could be measured quantitatively in the presence of other proteins, detergents, lipids, polyanions, and metal ions, all of which greatly affect the activity of PLC enzymes. polyanions 137-147 phospholipase C gamma 1 Bos taurus 29-35 2459119-12 1988 By using this method, PLC-I, PLC-II, and PLC-III could be measured quantitatively in the presence of other proteins, detergents, lipids, polyanions, and metal ions, all of which greatly affect the activity of PLC enzymes. polyanions 137-147 phospholipase C delta 1 Bos taurus 41-48 3169238-2 1988 These phosphate-containing polyanions accelerate the HCII-thrombin reaction, as much as 1600-fold in the case of phosvitin. polyanions 27-37 serpin family D member 1 Homo sapiens 53-57 3169238-2 1988 These phosphate-containing polyanions accelerate the HCII-thrombin reaction, as much as 1600-fold in the case of phosvitin. polyanions 27-37 coagulation factor II, thrombin Homo sapiens 58-66 3169238-0 1988 Antithrombin action of phosvitin and other phosphate-containing polyanions is mediated by heparin cofactor II. polyanions 64-74 serpin family C member 1 Homo sapiens 0-12 3169238-2 1988 These phosphate-containing polyanions accelerate the HCII-thrombin reaction, as much as 1600-fold in the case of phosvitin. polyanions 27-37 casein kinase 2 beta Homo sapiens 113-122 3169238-0 1988 Antithrombin action of phosvitin and other phosphate-containing polyanions is mediated by heparin cofactor II. polyanions 64-74 serpin family D member 1 Homo sapiens 90-109 3169238-1 1988 We have examined the antithrombin effects of various phosphate-containing polyanions (including linear polyphosphates, polynucleotides and the phosphoserine glycoprotein, phosvitin) on the glycosaminoglycan-binding plasma proteinase inhibitors, antithrombin III (ATIII) and heparin cofactor II (HCII). polyanions 74-84 serpin family C member 1 Homo sapiens 21-33 3169238-6 1988 Our results suggest that the antithrombotic effect of these phosphate-containing polyanions is mediated by HCII activation and not by ATIII. polyanions 81-91 serpin family D member 1 Homo sapiens 107-111 2825793-3 1987 Upon complexation, cytochrome c undergoes structural changes that are dependent on the size and charge of the polyanion, and on the pH and ionic strength of the medium. polyanions 110-119 cytochrome c, somatic Equus caballus 19-31 3421938-1 1988 Osteonectin, extracted from foetal porcine calvariae with 0.5 M-EDTA, was purified to homogeneity by using gel filtration and polyanion anion-exchange fast protein liquid chromatography under dissociative conditions without the need of reducing agents. polyanions 126-135 secreted protein acidic and cysteine rich Bos taurus 0-11 3167123-4 1988 Data from kinetic analysis and lysyl-tRNA synthetase modification by pyridoxal phosphate are suggestive of participation of the tRNA binding site in the enzyme interaction with polyanions. polyanions 177-187 lysine--tRNA ligase Oryctolagus cuniculus 31-52 3355612-4 1988 The concentration of total HDL-cholesterol was higher in the lower risk group due to a difference in HDL2-cholesterol when separation was achieved by polyanion precipitation, but not when separation was made by ultracentrifugation. polyanions 150-159 junctophilin 3 Homo sapiens 101-105 3024691-5 1986 It is concluded that the polyanion (liquoid)-induced intravascular coagulation-like reaction sequestered Fn concomitantly with the precipitation of fibrinogen and VII:Ag in the microclots. polyanions 25-34 fibronectin 1 Rattus norvegicus 105-107 3538890-0 1986 Epithelial polyanion (podocalyxin) is found on the sides but not the soles of the foot processes of the glomerular epithelium. polyanions 11-20 podocalyxin like Homo sapiens 22-33 3533998-1 1986 Glomerular visceral epithelial cells are endowed with a sialic acid-rich surface coat (the "glomerular epithelial polyanion"), which in rat tissue contains the sialoprotein podocalyxin. polyanions 114-124 cysteine-rich secretory protein 3 Rattus norvegicus 160-172 3533998-1 1986 Glomerular visceral epithelial cells are endowed with a sialic acid-rich surface coat (the "glomerular epithelial polyanion"), which in rat tissue contains the sialoprotein podocalyxin. polyanions 114-124 podocalyxin-like Rattus norvegicus 173-184 20493152-1 1986 Cholecystokinin-8 and neurotensin, neuropeptides found in relatively high concentrations in some catcholaminergic neurons and/or terminal or cell body areas, reduced native and polyanion-activated rat striatal tyrosine hydroxylase activity, but not that of the enzyme activated by phosphorylating conditions. polyanions 177-186 neurotensin Rattus norvegicus 0-33 20493152-4 1986 Cholecystokinin-8 and neurotensin may interact with polyanion-activated or membrane bound-activated tyrosine hydroxylase to modulate its activity. polyanions 52-61 neurotensin Rattus norvegicus 22-33 3896782-6 1985 It is shown that proteolytic conversion of lysyl-tRNA synthetase to a fully active dimer of Mr 2 X 64000, leads to loss of both the hydrophobic and the polyanion-binding properties. polyanions 152-161 lysine--tRNA ligase Ovis aries 43-64 3903338-0 1985 [Molecular pathology of the glomerular sialoglycoprotein podocalyxin, a major component of the glomerular polyanion in experimental and human minimal glomerular change]. polyanions 106-115 podocalyxin like Homo sapiens 57-68 3903338-4 1985 We conclude that the loss of histochemical staining for the "glomerular polyanion" is due both to the reduction of sialic acid per podocalyxin molecule, and to the reduction of the surface of the podocyte"s plasmalemma caused by spreading of footprocesses. polyanions 72-81 podocalyxin like Homo sapiens 131-142 6440307-10 1984 We conclude that even though PF4 binds to both polyanions and the platelet membrane, it does not promote the attachment of VIII:vWF. polyanions 47-57 platelet factor 4 Homo sapiens 29-32 6184611-5 1982 Polyanion-induced enzyme release was prevented after incubation of polyanions with highly purified C1q. polyanions 0-9 complement C1q A chain Homo sapiens 99-102 6381855-0 1984 Binding of platelet factor four (PF 4) to glomerular polyanion. polyanions 53-62 platelet factor 4 Rattus norvegicus 33-37 6368066-3 1984 Neuraminidase may also induce sialic acid depletion that would be expected to result in changes of the electrical charge in the immune complex as well as in the glomerular polyanion filtration barrier. polyanions 172-181 neuraminidase 1 Homo sapiens 0-13 6147249-0 1984 The interaction of skeletal myosin subfragment 1 with the polyanion, heparin. polyanions 58-67 myosin heavy chain 14 Homo sapiens 28-34 6184611-5 1982 Polyanion-induced enzyme release was prevented after incubation of polyanions with highly purified C1q. polyanions 67-77 complement C1q A chain Homo sapiens 99-102 6280764-1 1982 Citrate and other polyanion binding to ferricytochrome c partially blocks reduction by ascorbate, but at constant ionic strength the citrate-cytochrome c complex remains reducible; reduction by TMPD is unaffected. polyanions 18-27 cytochrome c, somatic Homo sapiens 44-56 7227541-0 1981 Reversible inhibition of ornithine decarboxylase by polyanions. polyanions 52-62 ornithine decarboxylase 1 Homo sapiens 25-48 6454580-0 1981 Activation of the alternative pathway of complement: efficient fluid-phase amplification by blockade of the regulatory complement protein beta1H through sulfated polyanions. polyanions 162-172 complement factor H Homo sapiens 138-144 6454580-3 1981 It is shown that particulate high-molecular weight sulfated polyanions are capable of reversible binding the guinea pig and human regulatory protein beta1H. polyanions 60-70 complement factor H Homo sapiens 149-155 6165356-0 1980 The effect of complex-formation with polyanions on the redox properties of cytochrome c. polyanions 37-47 cytochrome c, somatic Homo sapiens 75-87 6165356-9 1980 A similar pattern of inhibition and stimulation of reaction rates was observed when phosvitin was replaced by other macromolecular polyanions such as dextran sulphate and heparin, indicating that the results were a general property of complex-formation with polyanions. polyanions 258-268 casein kinase 2 beta Homo sapiens 84-93 6165356-12 1980 It is suggested that the effects of complex-formation with polyanions on the reactivity of cytochrome c with redox reagents are mainly the result of replacing the positive charge on the free cytochrome by a net negative charge. polyanions 59-69 cytochrome c, somatic Homo sapiens 91-103 7005056-1 1980 Laser light-scattering techniques have been used to study the effects of polyanions on the time-dependent interaction of (i) polystyrene particles and (ii) insulin-containing granules isolated from pancreatic islets. polyanions 73-83 insulin Homo sapiens 156-163 518998-0 1979 [Change in the activity of DNAse I inhibitor in the mouse spleen on the administration of a synthetic polyanion]. polyanions 102-111 deoxyribonuclease I Mus musculus 27-34 670702-8 1978 Molecules with negatively charged groups, like polyanions, or molecules with high electron dense groups, like DNP or TNP, can activate the C system via the classical pathway by binding directly to C1q. polyanions 47-57 complement C1q A chain Homo sapiens 197-200 195631-7 1977 Polyribonucleotides (polyadenylic acid and transfer RNA) inhibit both types of kinases, but the degree of inhibition of phosvitin kinase is variable and depends upon the type of the polyanion present. polyanions 182-191 casein kinase 2 beta Homo sapiens 120-129 203615-3 1977 Protein kinase activity can also be inhibited by polyanions which, like the protein inhibitor, bind to basic substrates but do not bind to the catalytic subunit of protein kinase. polyanions 49-59 protein kinase cAMP-activated catalytic subunit beta Bos taurus 0-14 21325-7 1977 Neuraminidase treatment of renal tissue removes the sialic acid-dependent glomerular polyanion staining but preserves and stabilizes the complement receptor. polyanions 85-94 neuraminidase 1 Homo sapiens 0-13 1277185-4 1976 Carbocyanine dye-binding polyanion (CPA) and the sialidase-sensitive fraction of this polyanion (SPA) have been determined in sera of 705 human subjects including healthy normal individuals and patients suffering from a broad spectrum of malignant and nonmalignant disease states. polyanions 86-95 surfactant protein A2 Homo sapiens 97-100 830761-8 1977 We suggest, therefore, C activation by polyanion-polycation interactions in the presence of CRP may be important to certain reactions of host defense and inflammation. polyanions 39-48 C-reactive protein Homo sapiens 92-95 186401-0 1976 Mode of interaction of different polyanions with the first (C1,C1) the second (C2) and the fourth (C4) component of complement. polyanions 33-43 heterogeneous nuclear ribonucleoprotein C Homo sapiens 60-65 186401-4 1976 Activation of C1 and C3 occurred at the same concentration of polyanions. polyanions 62-72 heterogeneous nuclear ribonucleoprotein C Homo sapiens 14-23 4122-2 1976 The activity of a partially purified preparation of tyrosine hydroxylase (EC 1.14.16.2) from the bovine caudate nucleus was increased by heparin, chondroitin sulfate, phosphatidylserine, polyacrylic acid, polyvinyl sulfuric acid and both poly-D-, and poly-L-glutamic acids, all polyanions. polyanions 278-288 tyrosine hydroxylase Bos taurus 52-72 4636641-0 1972 Action of sulfated polyanions used in blood culture on lysozyme, complement and antibiotics. polyanions 19-29 lysozyme Homo sapiens 55-63 5074781-0 1972 Lipoprotein-lipase modifications in subjects treated with a synthetic, heparin-like polyanion (SP 54). polyanions 84-93 lipoprotein lipase Homo sapiens 0-18 33692650-3 2021 Retention of neutrophil elastase within NETs is provided by ejected DNA chains, although this protein is also capable of interacting with a range of other endogenous polyanions, such as heparin and heparan sulfate. polyanions 166-176 elastase, neutrophil expressed Homo sapiens 13-32 13971070-0 1963 Inhibitory and activating effects of polyanions on lipoprotein lipase. polyanions 37-47 lipoprotein lipase Homo sapiens 51-69 4291123-0 1966 Inhibition of neuraminidase by polyanions. polyanions 31-41 neuraminidase 1 Homo sapiens 14-27 34051613-4 2021 The PF4 autoantigen is a polyanion molecule capable of independent interactions with negatively charged bacterial cellular wall, heparin and DNA molecules, thus linking intravascular innate immunity to both bacterial cell walls and pathogen-derived DNA. polyanions 25-34 platelet factor 4 Homo sapiens 4-7 33551060-1 2021 We report for the first time a chronopotentiometric measurement of polyanions based on localized ion depletion at the sample/membrane interface at a characteristic transition time tau, using polymer membrane polyanion-selective electrodes. polyanions 67-77 microtubule associated protein tau Homo sapiens 180-183 33551060-1 2021 We report for the first time a chronopotentiometric measurement of polyanions based on localized ion depletion at the sample/membrane interface at a characteristic transition time tau, using polymer membrane polyanion-selective electrodes. polyanions 67-76 microtubule associated protein tau Homo sapiens 180-183 32133839-4 2020 The polyanions were synthesized in aqueous medium by direct reaction of the monolacunary [beta2-GeW11O39]8- POM precursor with the corresponding lanthanide salts. polyanions 4-14 glycoprotein hormone subunit alpha 2 Homo sapiens 90-95 32849614-2 2020 Three binding sites for C3b and multiple polyanion binding sites have been identified on Factor H. polyanions 41-50 complement factor H Homo sapiens 89-97 32849614-13 2020 Immobilized heparin was used as a model polyanion and SPR confirmed the presence of heparin binding sites in CCP 6-8 (K d 1.2 muM) and in CCP 19-20 (4.9 muM) and suggested the existence of a weak third polyanion binding site in the center of Factor H (CCP 11-13). polyanions 40-49 AGBL carboxypeptidase 4 Homo sapiens 109-116 32717572-5 2020 We also show that simultaneous binding of the anion binding site of C1s by the polyanion is required to deliver the rate enhancement. polyanions 79-88 complement C1s Homo sapiens 68-71 32237268-2 2020 Platelet factor 4 (PF4) binds to polyanions on bacterial surfaces exposing neo-epitopes to which HIT-antibodies bind. polyanions 33-43 platelet factor 4 Homo sapiens 19-22 31799853-4 2019 This effective substitution of PSS polyanions in PDDA/PSS PEMs by PFO anions is suggested by the mechanism that the stability of PDDA/PFO complexes is higher than that of PDDA/PSS PEMs. polyanions 35-45 PSS Homo sapiens 31-34 32251304-8 2020 The effect of K18 on the yeast ribosome can be mitigated in the presence of cellular polyanions like heparin and tRNA, thereby indicating the electrostatic nature of the aggregation process. polyanions 85-95 keratin 18 Homo sapiens 14-17 31799853-4 2019 This effective substitution of PSS polyanions in PDDA/PSS PEMs by PFO anions is suggested by the mechanism that the stability of PDDA/PFO complexes is higher than that of PDDA/PSS PEMs. polyanions 35-45 PSS Homo sapiens 54-57 31799853-4 2019 This effective substitution of PSS polyanions in PDDA/PSS PEMs by PFO anions is suggested by the mechanism that the stability of PDDA/PFO complexes is higher than that of PDDA/PSS PEMs. polyanions 35-45 PSS Homo sapiens 54-57 30398188-4 2018 SC-XRD studies revealed that the polyanion crystallizes in the triclinic space group P-1. polyanions 33-42 crystallin gamma F, pseudogene Homo sapiens 85-88 30568677-6 2018 Based on the results, it was revealed that the polyanion/polycation molar ratio plays a critical role in modulating the characteristics of the inserts, and among all the formulations, the one comprising k-CA/CS PEC with molar ratio of (4:1), (k-CA/CS (4:1)), demonstrated the highest water uptake ability and mucoadhesive potential and provided a more controlled release of sumatriptan succinate. polyanions 47-56 casein kappa Homo sapiens 203-210 29645318-0 2018 Investigating the dynamics and polyanion binding sites of fibroblast growth factor-1 using hydrogen-deuterium exchange mass spectrometry. polyanions 31-40 fibroblast growth factor 1 Homo sapiens 58-84 29911701-4 2018 Interestingly, it is found that Li1+xFe1-xPO4 cannot be delithiated completely and thus cannot achieve extra capacity by anionic redox activity, because the local oxygen-ion redox will cause the fracture of the rigid framework formed by phosphate tetrahedral polyanions. polyanions 259-269 exportin 4 Homo sapiens 41-45 29346393-4 2018 In this study, we applied computational methods to elucidate molecular interactions between the repeat unit of the precisely alternating polyanion, Poly(4,4"-stilbenedicarboxylate-alt-maleic acid) (DCSti-alt-MA) and the V3 loop of gp120 from strains of HIV against which these polyanions were previously tested (IIIb, BaL, 92UG037, JR-CSF) as well as two strains for which gp120 crystal structures are available (YU2, 2B4C). polyanions 137-146 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 231-236 29346393-4 2018 In this study, we applied computational methods to elucidate molecular interactions between the repeat unit of the precisely alternating polyanion, Poly(4,4"-stilbenedicarboxylate-alt-maleic acid) (DCSti-alt-MA) and the V3 loop of gp120 from strains of HIV against which these polyanions were previously tested (IIIb, BaL, 92UG037, JR-CSF) as well as two strains for which gp120 crystal structures are available (YU2, 2B4C). polyanions 137-146 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 373-378 28712066-0 2017 Effect of pH and ionic strength on the binding strength of anti-PF4/polyanion antibodies. polyanions 68-77 platelet factor 4 Homo sapiens 64-67