PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29143789-5	2017	Here we acquire real-time profiles of fibril formation of superoxide dismutase 1 (SOD1) using high-sensitivity Rheo-NMR spectroscopy and detect weak and strong interactions between ThT and SOD1 fibrils in a time-dependent manner.	thioflavin T	181-184	superoxide dismutase 1	Homo sapiens	58-80
29143789-5	2017	Here we acquire real-time profiles of fibril formation of superoxide dismutase 1 (SOD1) using high-sensitivity Rheo-NMR spectroscopy and detect weak and strong interactions between ThT and SOD1 fibrils in a time-dependent manner.	thioflavin T	181-184	superoxide dismutase 1	Homo sapiens	82-86
28936869-1	2017	A novel catalyzed hairpin assembly-based turn-on ratiometric fluorescence biosensor was constructed for the determination of microRNA-122 (miRNA-122) by using 2-aminopurine (2-AP) and thioflavin T (ThT) as detection signal sources.	thioflavin T	184-196	microRNA 122	Homo sapiens	125-137
28936869-1	2017	A novel catalyzed hairpin assembly-based turn-on ratiometric fluorescence biosensor was constructed for the determination of microRNA-122 (miRNA-122) by using 2-aminopurine (2-AP) and thioflavin T (ThT) as detection signal sources.	thioflavin T	184-196	microRNA 122	Homo sapiens	139-148
28936869-1	2017	A novel catalyzed hairpin assembly-based turn-on ratiometric fluorescence biosensor was constructed for the determination of microRNA-122 (miRNA-122) by using 2-aminopurine (2-AP) and thioflavin T (ThT) as detection signal sources.	thioflavin T	198-201	microRNA 122	Homo sapiens	125-137
28936869-1	2017	A novel catalyzed hairpin assembly-based turn-on ratiometric fluorescence biosensor was constructed for the determination of microRNA-122 (miRNA-122) by using 2-aminopurine (2-AP) and thioflavin T (ThT) as detection signal sources.	thioflavin T	198-201	microRNA 122	Homo sapiens	139-148
28760825-0	2017	Modulation of the extent of structural heterogeneity in alpha-synuclein fibrils by the small molecule thioflavin T.	thioflavin T	102-114	synuclein alpha	Homo sapiens	56-71
28978309-6	2017	Interestingly, rBVPrP-109M and rBVPrP-109I exhibited distinct seeded aggregation pathways and aggregate morphologies upon seeding of mouse recombinant PrP fibrils, as monitored by thioflavin T fluorescence and electron microscopy.	thioflavin T	180-192	prion protein	Mus musculus	18-21
28970520-3	2017	In this work, we evaluate the capacity of ThT to photoswitch when bound to insulin amyloids by adjusting the redox properties of its environment.	thioflavin T	42-45	insulin	Homo sapiens	75-82
28527993-7	2017	The thioflavin T fluorescence intensity of the aqueous solution in the J-5 was extremely high despite the absence of heat-treatment.	thioflavin T	4-16	immunoglobulin kappa joining 5	Homo sapiens	71-74
28851223-0	2017	Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-beta Fibrils.	thioflavin T	11-23	amyloid beta precursor protein	Homo sapiens	68-80
28640595-4	2017	In this study, microscale thermophoresis (MST) was applied to assess the binding affinity of known small molecule ligands of alpha-synuclein fibrils, which were also tested in parallel in a thioflavin T fluorescence competition assay for further validation.	thioflavin T	190-202	synuclein alpha	Homo sapiens	125-140
28754988-7	2017	These structures are thioflavin-T-positive allowing to hypothesize the direct implication of zinc ions in pathological aggregation of TDP-43.	thioflavin T	21-33	TAR DNA binding protein	Homo sapiens	134-140
28763009-6	2017	Finally, we used thioflavin T fluorescence and electron microscopy images to show that Ni2+ binding induces the aggregating of Orb2 into structures that are distinct from the amyloid fibrils formed in the absence of Ni2+.	thioflavin T	17-29	ni2	Drosophila melanogaster	87-90
28763009-6	2017	Finally, we used thioflavin T fluorescence and electron microscopy images to show that Ni2+ binding induces the aggregating of Orb2 into structures that are distinct from the amyloid fibrils formed in the absence of Ni2+.	thioflavin T	17-29	orb2	Drosophila melanogaster	127-131
28798389-4	2017	Our thioflavin T fluorescence studies show that HNG inhibits IAPP misfolding at highly substoichiometric concentrations.	thioflavin T	4-16	islet amyloid polypeptide	Homo sapiens	61-65
28230965-7	2017	In thioflavin T fluorescence analysis, inhibited aggregation with prolonged lag time and reduced fluorescence intensity at equilibrium were observed when hIAPP was incubated together with FGQDs.	thioflavin T	3-15	islet amyloid polypeptide	Homo sapiens	154-159
28051995-7	2017	In comparison to healthy control iPS cells, we demonstrated the formation of transthyretin amyloid fibril-like structures in FAP HLC supernatants using the amyloid-specific dyes Congo red and thioflavin T.	thioflavin T	192-204	transthyretin	Homo sapiens	77-90
28416393-5	2017	In our model, increased TDP-43 was related to increased tau aggregation as evidenced by thioflavin S-positive phosphorylated tau, which may implicate TDP-43 expression in pre-tangle formation.	thioflavin T	88-100	TAR DNA binding protein	Mus musculus	24-30
28416393-5	2017	In our model, increased TDP-43 was related to increased tau aggregation as evidenced by thioflavin S-positive phosphorylated tau, which may implicate TDP-43 expression in pre-tangle formation.	thioflavin T	88-100	TAR DNA binding protein	Mus musculus	150-156
28274609-7	2017	Abeta in the brain was detected by western blot, ELISA and Thioflavin-S staining.	thioflavin T	59-71	amyloid beta precursor protein	Rattus norvegicus	0-5
28402629-2	2017	Using a combination of linear dichroism and fluorescence spectroscopies, we report that the relation between the emission intensity and binding of thioflavin-T to insulin fibrils is nonlinear and discuss this in relation to its use in kinetic assays.	thioflavin T	147-159	insulin	Homo sapiens	163-170
28273562-7	2017	Thioflavin T assay of Abeta fibrillisation kinetics demonstrated that one imidazolidine and both triazole compounds inhibited Abeta aggregation.	thioflavin T	0-12	amyloid beta precursor protein	Rattus norvegicus	22-27
28153312-3	2017	In this work, we proposed a novel label-free sensing strategy for T4 PNKP activity based on G-quadruplexe-thioflavin T fluorescent indicator.	thioflavin T	106-118	polynucleotide kinase 3'-phosphatase	Homo sapiens	69-73
28208281-5	2017	The TAGS assay can efficiently "tag" DNA fragments via using their DNA double-strand breaks (DSBs) to initiate the de novo synthesis of G-quadruplexes by TdT with an unmodified G-rich dNTP pool, followed by a rapid fluorescent readout upon the binding of thioflavin T (ThT), a fluorogenic dye highly specific for G-quadruplex.	thioflavin T	255-267	DNA nucleotidylexotransferase	Homo sapiens	154-157
28290684-6	2017	We eliminate the possibility that the disassembly occurs by the association between mPPCs and Abeta monomer/oligomers based on circular dichroism and Thioflavin T fluorescence assays.	thioflavin T	150-162	amyloid beta precursor protein	Homo sapiens	94-99
28292187-5	2017	We show that wild-type (wt) alphaSyn fibrils undergo a slow maturation over time after reaching the plateau phase of aggregation (as detected in a Thioflavin-T fluorescence assay).	thioflavin T	147-159	synuclein alpha	Homo sapiens	28-36
28000098-0	2017	Insulin Formulation Characterization-the Thioflavin T Assays.	thioflavin T	41-53	insulin	Homo sapiens	0-7
28000098-10	2017	The use of the ThT assay in research and characterization of insulin analogues, as well as formulations of insulin, is described by cases drawn from the scientific literature and patents.	thioflavin T	15-18	insulin	Homo sapiens	61-68
28007442-9	2017	Thioflavin T was used to monitor in situ alpha-synuclein fibril formation at pH7.0 and 4.5.	thioflavin T	0-12	alpha-synuclein	Ovis aries	41-56
28208281-5	2017	The TAGS assay can efficiently "tag" DNA fragments via using their DNA double-strand breaks (DSBs) to initiate the de novo synthesis of G-quadruplexes by TdT with an unmodified G-rich dNTP pool, followed by a rapid fluorescent readout upon the binding of thioflavin T (ThT), a fluorogenic dye highly specific for G-quadruplex.	thioflavin T	269-272	DNA nucleotidylexotransferase	Homo sapiens	154-157
27865970-5	2017	Here we investigate the role of each residue in the beta-strand aggregation process of H2 region of NPM1 by performing a systematic alanine scan of its sequence and structural and kinetic analyses of aggregation of derived peptides by means of Circular Dichorism (CD) and Thioflavin T (Th-T) assay.	thioflavin T	272-284	nucleophosmin 1	Homo sapiens	100-104
28069584-7	2017	Furthermore, thioflavin T fluorescence confirmed NE"s positive function of inhibiting Abeta aggregation through its weak binding with SNK(26-28) segment.	thioflavin T	13-25	polo like kinase 2	Homo sapiens	134-137
27865970-5	2017	Here we investigate the role of each residue in the beta-strand aggregation process of H2 region of NPM1 by performing a systematic alanine scan of its sequence and structural and kinetic analyses of aggregation of derived peptides by means of Circular Dichorism (CD) and Thioflavin T (Th-T) assay.	thioflavin T	286-290	nucleophosmin 1	Homo sapiens	100-104
27889337-0	2017	Characterization and analysis of binding of Thioflavin T with partially folded and native states of alpha-lactalbumin protein by calorimetric and spectroscopic techniques.	thioflavin T	44-56	lactalbumin alpha	Homo sapiens	100-117
27889337-1	2017	We have analysed binding of Thioflavin T (ThT) with molten globule (MG) and native (N) states of alpha-lactalbumin (alpha-LA) by using calorimetry and spectroscopy.	thioflavin T	28-40	lactalbumin alpha	Homo sapiens	97-114
27889337-1	2017	We have analysed binding of Thioflavin T (ThT) with molten globule (MG) and native (N) states of alpha-lactalbumin (alpha-LA) by using calorimetry and spectroscopy.	thioflavin T	28-40	lactalbumin alpha	Homo sapiens	116-124
27889337-1	2017	We have analysed binding of Thioflavin T (ThT) with molten globule (MG) and native (N) states of alpha-lactalbumin (alpha-LA) by using calorimetry and spectroscopy.	thioflavin T	42-45	lactalbumin alpha	Homo sapiens	97-114
27889337-1	2017	We have analysed binding of Thioflavin T (ThT) with molten globule (MG) and native (N) states of alpha-lactalbumin (alpha-LA) by using calorimetry and spectroscopy.	thioflavin T	42-45	lactalbumin alpha	Homo sapiens	116-124
27889337-4	2017	Our novel and most important observation is non-fluorescent mode of binding of ThT to the MG state of alpha-LA suggesting that the mechanism of binding is distinctly different from that of association with the protein fibrils.	thioflavin T	79-82	lactalbumin alpha	Homo sapiens	102-110
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	43-46	lactalbumin alpha	Homo sapiens	75-83
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	43-46	lactalbumin alpha	Homo sapiens	202-210
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	43-46	lactalbumin alpha	Homo sapiens	202-210
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	75-83
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	202-210
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	202-210
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	75-83
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	202-210
27889337-6	2017	The thermodynamic parameters of binding of ThT with the MG and N states of alpha-LA obtained from Isothermal Titration Calorimetry (ITC) experiments show the formation of stable complex between ThT and alpha-LA (both MG and N states) and also provide insights on the probable mode of interaction of ThT with the MG and N states of alpha-LA.	thioflavin T	194-197	lactalbumin alpha	Homo sapiens	202-210
28140404-4	2017	Female EFAD transgenic mice (5xFAD+/-/human APOE e3 or e4+/+) with 225 h exposure to urban nanosized PM (nPM) over 15 weeks showed increased cerebral beta-amyloid by thioflavin S for fibrillary amyloid and by immunocytochemistry for Abeta deposits, both exacerbated by APOE e4.	thioflavin T	166-178	apolipoprotein E	Homo sapiens	44-48
27794588-2	2017	Here, we have developed a simple and convenient detection system using the interaction between G-quadruplex and fluorophore thioflavin T (ThT) for discriminating EGFR exon 19 deletion mutant DNA from wild type without a label and quencher.	thioflavin T	124-136	epidermal growth factor receptor	Homo sapiens	162-166
27794588-2	2017	Here, we have developed a simple and convenient detection system using the interaction between G-quadruplex and fluorophore thioflavin T (ThT) for discriminating EGFR exon 19 deletion mutant DNA from wild type without a label and quencher.	thioflavin T	138-141	epidermal growth factor receptor	Homo sapiens	162-166
28123067-4	2017	After reduction of human tau in this mouse model of tauopathy, fewer tau inclusions developed, and preexisting phosphorylated tau and Thioflavin S pathology were reversed.	thioflavin T	134-144	microtubule associated protein tau	Homo sapiens	25-28
27927987-6	2017	Abeta preparations were characterized with transmission electron microscopy and thioflavin T fluorescence.	thioflavin T	80-92	amyloid beta precursor protein	Homo sapiens	0-5
27784218-5	2017	FRET based assay was used to evaluate beta-secretase inhibition using DABCYL- Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-EDANS as substrate and beta-amyloid peptide spontaneous aggregation assay was performed using the thioflavin T spectroscopy assay.	thioflavin T	212-224	amyloid beta precursor protein	Homo sapiens	137-157
27591637-1	2016	We have developed a new methodology for fluorescence turn-on detection of uracil DNA glycosylase (UDG) activity based on G-quadruplex formation using a thioflavin T probe.	thioflavin T	152-164	uracil DNA glycosylase	Homo sapiens	74-96
27744056-4	2017	Thioflavin T (ThT) binding assay was used to monitor the fibrillation process of human serum albumin (HSA) at 65 C in the presence and absence of levodopa.	thioflavin T	0-12	albumin	Homo sapiens	87-100
27744056-4	2017	Thioflavin T (ThT) binding assay was used to monitor the fibrillation process of human serum albumin (HSA) at 65 C in the presence and absence of levodopa.	thioflavin T	14-17	albumin	Homo sapiens	87-100
27998088-5	2016	Amyloid fibril formation of GLP-1 was monitored using thioflavin T fluorescence as a function of peptide concentration between pH 7.5 and 8.2.	thioflavin T	54-66	glucagon	Homo sapiens	28-33
27791396-8	2016	Using the thioflavin T (ThT) assay, an increased fraction of the soluble oligomer of each Abeta analog was transiently detected during fibrillation.	thioflavin T	10-22	amyloid beta precursor protein	Homo sapiens	90-95
27791396-8	2016	Using the thioflavin T (ThT) assay, an increased fraction of the soluble oligomer of each Abeta analog was transiently detected during fibrillation.	thioflavin T	24-27	amyloid beta precursor protein	Homo sapiens	90-95
27445316-12	2016	Negative stain EM, dot blot analysis and ThT plate assays showed that recombinant CRES2, CRES3 and cystatin E2 formed amyloid in vitro, albeit with different aggregation properties.	thioflavin T	41-44	cystatin 11	Mus musculus	82-87
27445316-12	2016	Negative stain EM, dot blot analysis and ThT plate assays showed that recombinant CRES2, CRES3 and cystatin E2 formed amyloid in vitro, albeit with different aggregation properties.	thioflavin T	41-44	cystatin domain containing 2	Mus musculus	99-110
28004763-3	2016	Whereas the initial protein-membrane interaction involves the N-terminal tail that constitutes an extension of the regulatory ACT-domain, prolonged membrane binding induces misfolding and self-oligomerization of TH over time as shown by circular dichroism and Thioflavin T fluorescence.	thioflavin T	260-272	tyrosine hydroxylase	Rattus norvegicus	212-214
27999248-0	2016	A Sensitive and Label-Free Pb(II) Fluorescence Sensor Based on a DNAzyme Controlled G-Quadruplex/Thioflavin T Conformation.	thioflavin T	97-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	27-33
27999248-3	2016	In the presence of Pb(II), a G-rich tail was cut and released from the substrate strand, which then would form a G-quadruplex structure by combination with ThT dye.	thioflavin T	156-159	submaxillary gland androgen regulated protein 3B	Homo sapiens	19-25
27590320-0	2016	Thioflavin T as a fluorescence light-up probe for both parallel and antiparallel G-quadruplexes of 29-mer thrombin binding aptamer.	thioflavin T	0-12	coagulation factor II, thrombin	Homo sapiens	106-114
27687332-7	2016	Furthermore, the Thioflavin T (THT) fluorescence confirmed DA"s positive function of inhibiting Abeta aggregation through its weakly binding with SNK(26-28) segment.	thioflavin T	17-29	polo like kinase 2	Homo sapiens	146-149
27687332-7	2016	Furthermore, the Thioflavin T (THT) fluorescence confirmed DA"s positive function of inhibiting Abeta aggregation through its weakly binding with SNK(26-28) segment.	thioflavin T	31-34	polo like kinase 2	Homo sapiens	146-149
27591637-1	2016	We have developed a new methodology for fluorescence turn-on detection of uracil DNA glycosylase (UDG) activity based on G-quadruplex formation using a thioflavin T probe.	thioflavin T	152-164	uracil DNA glycosylase	Homo sapiens	98-101
28192290-6	2016	The review also highlights time-resolved fluorescence as a promising tool to study the critical conformational transitions associated with early oligomerization of alpha-Syn, which are otherwise not accessible using other commonly used techniques such as thioflavin T (ThT) binding assay.	thioflavin T	255-267	synuclein alpha	Homo sapiens	164-173
27601475-6	2016	S-guanylated tau inhibited heparin-induced tau aggregation in a thioflavin T assay.	thioflavin T	64-76	microtubule associated protein tau	Homo sapiens	13-16
27601475-6	2016	S-guanylated tau inhibited heparin-induced tau aggregation in a thioflavin T assay.	thioflavin T	64-76	microtubule associated protein tau	Homo sapiens	43-46
28192290-6	2016	The review also highlights time-resolved fluorescence as a promising tool to study the critical conformational transitions associated with early oligomerization of alpha-Syn, which are otherwise not accessible using other commonly used techniques such as thioflavin T (ThT) binding assay.	thioflavin T	269-272	synuclein alpha	Homo sapiens	164-173
27633857-6	2016	Inhibition of BAG-1 binding to HSC70 by the small-molecule chemical inhibitor, Thioflavin-S, and a short peptide derived from the C-terminal BAG domain, which mediates binding with the ATPase domain of HSC70, resulted in significant downregulation of E2/ER-facilitated BMP-2-directed osteogenic differentiation of BMSCs.	thioflavin T	79-91	BCL2-associated athanogene 1	Mus musculus	14-19
27479186-5	2016	The kinetics of human amylin amyloid formation can be monitored by SYPRO-orange fluorescence and match the time course determined with thioflavin-T assays.	thioflavin T	135-147	islet amyloid polypeptide	Homo sapiens	22-28
27633857-6	2016	Inhibition of BAG-1 binding to HSC70 by the small-molecule chemical inhibitor, Thioflavin-S, and a short peptide derived from the C-terminal BAG domain, which mediates binding with the ATPase domain of HSC70, resulted in significant downregulation of E2/ER-facilitated BMP-2-directed osteogenic differentiation of BMSCs.	thioflavin T	79-91	heat shock protein 8	Mus musculus	31-36
27108954-5	2016	Here we investigate the effect of Abeta methionine oxidation on fiber formation kinetics and morphology using the amyloid specific fluorescence dye Thioflavin T (ThT) and Transmission Electron Microscopy (TEM).	thioflavin T	148-160	amyloid beta precursor protein	Homo sapiens	34-39
27600721-4	2016	Light scattering, thioflavin T (ThT) and high hydrostatic pressure (HHP) assays showed that p53 DBD aggregates faster and to a greater extent than p63 and p73 DBDs, and was more susceptible to denaturation.	thioflavin T	18-30	tumor protein p53	Homo sapiens	92-95
27600721-4	2016	Light scattering, thioflavin T (ThT) and high hydrostatic pressure (HHP) assays showed that p53 DBD aggregates faster and to a greater extent than p63 and p73 DBDs, and was more susceptible to denaturation.	thioflavin T	32-35	tumor protein p53	Homo sapiens	92-95
27382062-5	2016	We also characterized these alpha-syn species by means of electron microscopy and thioflavin fluorescence assays and found that fragmented beta sheet-rich fibrous structures of alpha-syn with a length of 50 nm or less are the most efficient promoters of accumulation of phosphorylated alpha-syn, which is the hallmark of alpha-synucleinopathies.	thioflavin T	82-92	synuclein, alpha	Mus musculus	28-37
27382062-5	2016	We also characterized these alpha-syn species by means of electron microscopy and thioflavin fluorescence assays and found that fragmented beta sheet-rich fibrous structures of alpha-syn with a length of 50 nm or less are the most efficient promoters of accumulation of phosphorylated alpha-syn, which is the hallmark of alpha-synucleinopathies.	thioflavin T	82-92	synuclein, alpha	Mus musculus	177-186
27382062-5	2016	We also characterized these alpha-syn species by means of electron microscopy and thioflavin fluorescence assays and found that fragmented beta sheet-rich fibrous structures of alpha-syn with a length of 50 nm or less are the most efficient promoters of accumulation of phosphorylated alpha-syn, which is the hallmark of alpha-synucleinopathies.	thioflavin T	82-92	synuclein, alpha	Mus musculus	177-186
27108954-5	2016	Here we investigate the effect of Abeta methionine oxidation on fiber formation kinetics and morphology using the amyloid specific fluorescence dye Thioflavin T (ThT) and Transmission Electron Microscopy (TEM).	thioflavin T	162-165	amyloid beta precursor protein	Homo sapiens	34-39
27503075-5	2016	The seeded inclusions contain posttranslationally modified alpha-syn that is Thioflavin S positive, indicative of amyloid fibrils.	thioflavin T	77-89	synuclein, alpha	Mus musculus	59-68
27165642-2	2016	Here, we used (1) H NMR spectroscopy to determine the binding mode of ThT on the surface of fibrils from lysozyme and insulin.	thioflavin T	70-73	insulin	Homo sapiens	118-125
27546208-2	2016	We describe here an approach to the analysis of the Abeta aggregation mechanism that uses Abeta-polyglutamine hybrid peptides designed to retard amyloid maturation and an adjusted thioflavin intensity scale that reveals structural features of aggregation intermediates.	thioflavin T	180-190	amyloid beta precursor protein	Homo sapiens	52-57
27129292-2	2016	In the present study, we report that smooth muscle titin (SMT; 500 kDa) from chicken gizzard forms amyloid aggregates in vitro This conclusion is supported by EM data, fluorescence analysis using thioflavin T (ThT), Congo red (CR) spectroscopy and X-ray diffraction.	thioflavin T	196-208	titin	Bos taurus	51-56
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	124-136	beta-2-microglobulin	Homo sapiens	62-81
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	124-136	insulin	Homo sapiens	86-93
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	138-141	beta-2-microglobulin	Homo sapiens	62-81
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	138-141	insulin	Homo sapiens	86-93
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	204-207	beta-2-microglobulin	Homo sapiens	62-81
27345358-2	2016	When we induced the ultrasonication-dependent fibrillation of beta2-microglobulin and insulin monitored by amyloid-specific thioflavin T (ThT) fluorescence, both proteins showed a significant decrease in ThT fluorescence after the burst-phase increase.	thioflavin T	204-207	insulin	Homo sapiens	86-93
27228180-0	2016	Stoichiometry and Affinity of Thioflavin T Binding to Sup35p Amyloid Fibrils.	thioflavin T	30-42	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	54-59
27144293-4	2016	Other compounds, such as thioflavin T, bind TTR amyloid fibrils.	thioflavin T	25-37	transthyretin	Homo sapiens	44-47
27322259-4	2016	Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays.	thioflavin T	146-158	islet amyloid polypeptide	Homo sapiens	110-116
26965570-4	2016	S100A9 oligomers and fibrils were generated in vitro and verified by AFM, Thioflavin T and A11 antibody binding.	thioflavin T	74-86	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	0-6
26970755-7	2016	RESULTS: Cholesterol loading and microRNA-33-induced reduction in islet ABCA1 expression increased Thioflavin S-positive amyloid in hIAPP (Tg/o) islets.	thioflavin T	99-111	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	72-77
26970755-7	2016	RESULTS: Cholesterol loading and microRNA-33-induced reduction in islet ABCA1 expression increased Thioflavin S-positive amyloid in hIAPP (Tg/o) islets.	thioflavin T	99-111	islet amyloid polypeptide	Homo sapiens	132-137
27129292-2	2016	In the present study, we report that smooth muscle titin (SMT; 500 kDa) from chicken gizzard forms amyloid aggregates in vitro This conclusion is supported by EM data, fluorescence analysis using thioflavin T (ThT), Congo red (CR) spectroscopy and X-ray diffraction.	thioflavin T	210-213	titin	Bos taurus	51-56
27067251-4	2016	Using the thioflavin T fluorescence assay, atomic force microscopy, circular dichroism and nuclear magnetic resonance measurements, we demonstrate that CSA has an intensive promotion effect on the fibrillation of hIAPP at the POPC membrane, which is larger than the total effect of CSA alone and POPC alone.	thioflavin T	10-22	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	152-155
27067251-4	2016	Using the thioflavin T fluorescence assay, atomic force microscopy, circular dichroism and nuclear magnetic resonance measurements, we demonstrate that CSA has an intensive promotion effect on the fibrillation of hIAPP at the POPC membrane, which is larger than the total effect of CSA alone and POPC alone.	thioflavin T	10-22	islet amyloid polypeptide	Homo sapiens	213-218
26772162-9	2016	We demonstrated that the initial concentration of Abeta during the HFIP pretreatment altered the kinetic profiles of Abeta fibril formation in a thioflavin T fluorescence assay.	thioflavin T	145-157	amyloid beta precursor protein	Homo sapiens	50-55
26772162-9	2016	We demonstrated that the initial concentration of Abeta during the HFIP pretreatment altered the kinetic profiles of Abeta fibril formation in a thioflavin T fluorescence assay.	thioflavin T	145-157	amyloid beta precursor protein	Homo sapiens	117-122
26710111-10	2016	Thioflavin T assays revealed that exosomal PrP(C) accelerates fibrillization of amyloid beta, thereby reducing neurotoxic effects imparted by oligomeric Abeta.	thioflavin T	0-12	prion protein	Homo sapiens	43-49
26710111-10	2016	Thioflavin T assays revealed that exosomal PrP(C) accelerates fibrillization of amyloid beta, thereby reducing neurotoxic effects imparted by oligomeric Abeta.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	80-92
26699836-7	2016	Thioflavin T fluorescence data and atomic force microscopy images demonstrate that both CHICUP and PICUP stabilize Abeta oligomers and attenuate fibril formation.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	115-120
26855360-0	2016	Label-free monitoring of DNA methyltransferase activity based on terminal deoxynucleotidyl transferase using a thioflavin T probe.	thioflavin T	111-123	DNA nucleotidylexotransferase	Homo sapiens	65-102
26855360-1	2016	We have developed a new methodology for fluorescence turn-on detection of DNA methyltransferase (MTase) activity based on terminal deoxynucleotidyl transferase (TdT) using a thioflavin T probe.	thioflavin T	174-186	DNA nucleotidylexotransferase	Homo sapiens	122-159
26855360-1	2016	We have developed a new methodology for fluorescence turn-on detection of DNA methyltransferase (MTase) activity based on terminal deoxynucleotidyl transferase (TdT) using a thioflavin T probe.	thioflavin T	174-186	DNA nucleotidylexotransferase	Homo sapiens	161-164
27010102-1	2016	In this work, we prepared a type of thioflavin T (ThT)-doped lanthanide/nucleotide coordination polymer by the self-assembly of ThT, europium ions (Eu(3+)) and nucleotides (guanosine monophosphate, GMP) in aqueous solution (i.e. ThT/Eu/GMP).	thioflavin T	36-48	5'-nucleotidase, cytosolic II	Homo sapiens	198-201
27010102-1	2016	In this work, we prepared a type of thioflavin T (ThT)-doped lanthanide/nucleotide coordination polymer by the self-assembly of ThT, europium ions (Eu(3+)) and nucleotides (guanosine monophosphate, GMP) in aqueous solution (i.e. ThT/Eu/GMP).	thioflavin T	36-48	5'-nucleotidase, cytosolic II	Homo sapiens	236-239
27010102-1	2016	In this work, we prepared a type of thioflavin T (ThT)-doped lanthanide/nucleotide coordination polymer by the self-assembly of ThT, europium ions (Eu(3+)) and nucleotides (guanosine monophosphate, GMP) in aqueous solution (i.e. ThT/Eu/GMP).	thioflavin T	50-53	5'-nucleotidase, cytosolic II	Homo sapiens	198-201
27010102-1	2016	In this work, we prepared a type of thioflavin T (ThT)-doped lanthanide/nucleotide coordination polymer by the self-assembly of ThT, europium ions (Eu(3+)) and nucleotides (guanosine monophosphate, GMP) in aqueous solution (i.e. ThT/Eu/GMP).	thioflavin T	50-53	5'-nucleotidase, cytosolic II	Homo sapiens	236-239
27010102-2	2016	The Eu/GMP coordination polymers show excellent adaptive inclusion properties for ThT in a convenient one-step approach, which can readily enhance the fluorescence of ThT via the restricted effect.	thioflavin T	82-85	5'-nucleotidase, cytosolic II	Homo sapiens	7-10
27010102-2	2016	The Eu/GMP coordination polymers show excellent adaptive inclusion properties for ThT in a convenient one-step approach, which can readily enhance the fluorescence of ThT via the restricted effect.	thioflavin T	167-170	5'-nucleotidase, cytosolic II	Homo sapiens	7-10
27010102-3	2016	Moreover, the as-prepared hydrophilic ThT/Eu/GMP coordination polymers have the capability to act as a temperature-sensitive, visual and reversible sensor in aqueous solution under the irradiation of visible light.	thioflavin T	38-41	5'-nucleotidase, cytosolic II	Homo sapiens	45-48
26808649-4	2016	This finding is supported by high-throughput dynamic light scattering experiment and thioflavin T assay, where the rapid evolution of hIAPP nucleation and elongation processes is halted by the addition of the dendrimer up to 8 h. Discrete molecular dynamics simulations further reveal that hIAPP residues bound strongly with the dendrimer near the c-terminal portion of the peptide, where the amyloidogenic sequence (residues 22-29) locates.	thioflavin T	85-97	islet amyloid polypeptide	Homo sapiens	134-139
27000658-5	2016	We use the specific amyloid dye Thioflavin-S (Th-S) to stain bacterial inclusion bodies (IBs), in this case mainly formed of Abeta in amyloid conformation.	thioflavin T	32-44	amyloid beta precursor protein	Homo sapiens	125-130
27000658-5	2016	We use the specific amyloid dye Thioflavin-S (Th-S) to stain bacterial inclusion bodies (IBs), in this case mainly formed of Abeta in amyloid conformation.	thioflavin T	46-50	amyloid beta precursor protein	Homo sapiens	125-130
26843409-2	2016	The impact of sodium, potassium, choline, guanidinium, and 1-ethyl-3-methylimidazolium chloride on the fibrillation kinetics of insulin in an acid-denaturing solvent environment is studied by fluorescence spectroscopy using thioflavin T as a fibril-specific stain.	thioflavin T	224-236	insulin	Homo sapiens	128-135
26657584-7	2016	The formation of beta-lg self-assembly was confirmed by Thioflavin T studies, Congo red assay, Rayleigh scattering and dynamic light scattering analysis.	thioflavin T	56-68	beta-lactoglobulin	Bos taurus	17-24
29899907-3	2016	Herein, by employing Thioflavin T (ThT) as a signal transducer, we integrated multiple components based on RET (a type of proto-oncogene) into a logic gate combinatorial library, including basic logic gates (NOR, INHIBIT, IMPLICATION), a single three-input NOR gate, and combinatorial gates (INHIBIT-OR, NOT-AND-NOR).	thioflavin T	21-33	ret proto-oncogene	Homo sapiens	107-110
29899907-3	2016	Herein, by employing Thioflavin T (ThT) as a signal transducer, we integrated multiple components based on RET (a type of proto-oncogene) into a logic gate combinatorial library, including basic logic gates (NOR, INHIBIT, IMPLICATION), a single three-input NOR gate, and combinatorial gates (INHIBIT-OR, NOT-AND-NOR).	thioflavin T	35-38	ret proto-oncogene	Homo sapiens	107-110
26741409-6	2016	We illustrate the approach with results from the aggregation of the beta-amyloid (Abeta) peptides measured using thioflavin T, but the method is suitable for data from any similar kinetic experiment measuring the accumulation of aggregate mass as a function of time; the input data are in the form of a tab-separated text file.	thioflavin T	113-125	amyloid beta precursor protein	Homo sapiens	68-88
26960610-2	2016	The sensitivity of this method is higher than that of the current fibril-specific detection method using probe dye, such as thioflavin T, for which sub-muM level of fibrils are necessary.	thioflavin T	124-136	latexin	Homo sapiens	152-155
26456030-5	2016	We demonstrated that TAN I and TAN IIA inhibited the aggregation of alpha-synuclein as demonstrated by the prolonged lag time and the reduced thioflavin-T fluorescence intensity; TAN I and TAN IIA also disaggregated preformed mature fibrils in vitro.	thioflavin T	142-154	synuclein alpha	Homo sapiens	68-83
27965913-5	2016	This was supported by the observations that phosphorylated alpha-syn oligomers entered neurons, rapidly increased accumulated thioflavin S-positive inclusions, and induced a series of metabolic changes that included activation of polo-like kinase 2, inhibition of glucocerebrosidase and protein phosphatase 2A, and reduction of ceramide levels, all of which have been shown to promote alpha-syn phosphorylation and aggregation.	thioflavin T	126-138	synuclein alpha	Homo sapiens	59-68
26923013-6	2016	Yet, combined therapy enhanced thioflavin-S labeled Abeta plaque burden, a tendency not significant when Abeta1 - 42 plaque load was considered.	thioflavin T	31-43	amyloid beta (A4) precursor protein	Mus musculus	52-57
26656730-5	2015	These EP2-derivated nanofibers promptly accelerated the formation of semen amyloid fibrils by PAP248-286, as shown by Thioflavin T (ThT) and Congo red assays.	thioflavin T	118-130	sperm associated antigen 11B	Homo sapiens	6-9
27586184-2	2016	The global conformational changes in Hb in the presence of ACN were studied using intrinsic fluorescence experiments, acrylamide quenching, ANS fluorescence measurements, soret absorbance spectroscopy, fourier transform infrared spectroscopy, circular dichroism, thioflavin T and congo red assay.	thioflavin T	263-275	apoptotic chromatin condensation inducer 1	Homo sapiens	59-62
26574169-4	2015	In this study, fluorescence correlation spectroscopy (FCS) and Thioflavin T (ThT) were used to monitor the time dependent growth of structured aggregates and characterize multiple components during the aggregation of Abeta peptides in a heterogeneous aqueous solution.	thioflavin T	77-80	amyloid beta precursor protein	Homo sapiens	217-222
26656730-5	2015	These EP2-derivated nanofibers promptly accelerated the formation of semen amyloid fibrils by PAP248-286, as shown by Thioflavin T (ThT) and Congo red assays.	thioflavin T	132-135	sperm associated antigen 11B	Homo sapiens	6-9
26612754-9	2015	Biochemical analysis showed that brains of mice injected with brain extracts from patients with MSA and probable iLBD contained hyperphosphorylated alpha-synuclein that also seeded aggregation of recombinant human wild-type alpha-synuclein in a Thioflavin T binding assay.	thioflavin T	245-257	synuclein alpha	Homo sapiens	148-163
26577032-1	2015	We have developed a new methodology for label-free fluorescence turn-on detection of T4 polynucleotide kinase/phosphatase activity (T4 PNKP) using a Thioflavin T probe.	thioflavin T	149-161	polynucleotide kinase 3'-phosphatase	Homo sapiens	135-139
26190022-6	2015	This paper reports that wild-type and Italian-mutant Abeta both form fibrils characterized by the cross-beta architecture, but with distinct beta-sheet organizations, resulting in differences in thioflavin T fluorescence and solvent accessibility.	thioflavin T	195-207	amyloid beta precursor protein	Homo sapiens	53-58
26612754-9	2015	Biochemical analysis showed that brains of mice injected with brain extracts from patients with MSA and probable iLBD contained hyperphosphorylated alpha-synuclein that also seeded aggregation of recombinant human wild-type alpha-synuclein in a Thioflavin T binding assay.	thioflavin T	245-257	synuclein alpha	Homo sapiens	224-239
26571264-3	2015	The kinetics of lysozyme aggregation, monitored by Thioflavin T fluorescence, dynamic light scattering and the quenching of tryptophan fluorescence by acrylamide, is described by a sigmoid curve typical of a nucleation-dependent polymerization process.	thioflavin T	51-63	lysozyme	Homo sapiens	16-24
26600248-6	2015	Aggregation kinetics of pEAbeta(3-40) in the presence of 20% TFE monitored by thioflavin-T (ThT) assay showed a typical sigmoidal aggregation in contrast to Abeta(1-40), which lacks ThT positive structures under the same conditions.	thioflavin T	78-90	amyloid beta precursor protein	Homo sapiens	26-31
26600248-6	2015	Aggregation kinetics of pEAbeta(3-40) in the presence of 20% TFE monitored by thioflavin-T (ThT) assay showed a typical sigmoidal aggregation in contrast to Abeta(1-40), which lacks ThT positive structures under the same conditions.	thioflavin T	92-95	amyloid beta precursor protein	Homo sapiens	26-31
26600248-6	2015	Aggregation kinetics of pEAbeta(3-40) in the presence of 20% TFE monitored by thioflavin-T (ThT) assay showed a typical sigmoidal aggregation in contrast to Abeta(1-40), which lacks ThT positive structures under the same conditions.	thioflavin T	182-185	amyloid beta precursor protein	Homo sapiens	26-31
26457972-0	2015	Ultrafast Torsional Relaxation of Thioflavin-T in Tris(pentafluoroethyl)trifluorophosphate (FAP) Anion-Based Ionic Liquids.	thioflavin T	34-46	fibroblast activation protein alpha	Homo sapiens	92-95
26093169-6	2015	alpha-Syn accumulations co-localized with ubiquitin, p62, and were thioflavin-S-positive and proteinase-k resistant, suggesting that PFF-induced pathology exhibits properties similar to human LBs.	thioflavin T	67-79	synuclein alpha	Homo sapiens	0-9
26359500-5	2015	Co-incubation of Abeta40 with small amounts of GAPDH aggregates significantly enhanced Abeta40 amyloidogenesis, as assessed by in vitro thioflavin-T assays.	thioflavin T	136-148	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	47-52
26162702-4	2015	Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Abeta aggregation process in a concentration-dependent manner.	thioflavin T	33-45	serine peptidase inhibitor Kazal type 1	Homo sapiens	105-108
26162702-4	2015	Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Abeta aggregation process in a concentration-dependent manner.	thioflavin T	47-51	serine peptidase inhibitor Kazal type 1	Homo sapiens	105-108
26104290-6	2015	Upregulation of TNF-alpha, cleaved caspase-3, and Thioflavin-S-positive aggregates was observed in the ipsilateral hemispheres of the GET-1 brains as early as 3 days after ischemia.	thioflavin T	50-62	grainyhead like transcription factor 3	Mus musculus	134-139
26340532-5	2015	The Thioflavin T (ThT) assay and various spectroscopic and microscopic techniques establish that the PDI-HIS molecules accelerate the Abeta1-40 and the amyloid aggregates in CSF into micro size coassembled structures.	thioflavin T	4-16	peptidyl arginine deiminase 1	Homo sapiens	101-104
26340532-5	2015	The Thioflavin T (ThT) assay and various spectroscopic and microscopic techniques establish that the PDI-HIS molecules accelerate the Abeta1-40 and the amyloid aggregates in CSF into micro size coassembled structures.	thioflavin T	18-21	peptidyl arginine deiminase 1	Homo sapiens	101-104
26134353-3	2015	In this work, taking T4 polynucleotide kinase (PNK) as a model, the ThT/G-quadruplex based platform and lambdaexonuclease (lambdaexo) cleavage reaction were combined to design a label-free "turn-on" strategy for fast, simple and accurate detection of T4 PNK activity and its inhibition.	thioflavin T	68-71	polynucleotide kinase 3'-phosphatase	Homo sapiens	47-50
26420657-7	2015	Furthermore, the crystal structure of DimC33 in complex with the amyloid-specific dye Thioflavin-T pinpoints a second interface, which likely participates in the first steps of beta2m aggregation.	thioflavin T	86-98	beta-2-microglobulin	Homo sapiens	177-183
26246183-1	2015	In this communication, using sub-picosecond resolved fluorescence upconversion spectroscopy, we discover that despite a large fluorescence enhancement observed for thioflavin-T in insulin fibrils, the majority of fibril bound thioflavin-T undergoes efficient ultrafast conformational relaxation, and thus does not contribute to the characteristic fluorescence enhancement.	thioflavin T	164-176	insulin	Homo sapiens	180-187
26134353-3	2015	In this work, taking T4 polynucleotide kinase (PNK) as a model, the ThT/G-quadruplex based platform and lambdaexonuclease (lambdaexo) cleavage reaction were combined to design a label-free "turn-on" strategy for fast, simple and accurate detection of T4 PNK activity and its inhibition.	thioflavin T	68-71	polynucleotide kinase 3'-phosphatase	Homo sapiens	254-257
26134353-4	2015	In the presence of T4 PNK, the designed thioflavin T based molecular beacon (TMB) DNA probe could be phosphorylated and then digested by the cleavage of lambdaexo, releasing the G-quartets.	thioflavin T	40-52	polynucleotide kinase 3'-phosphatase	Homo sapiens	22-25
26134353-5	2015	These then bound to ThT to form ThT/G-quadruplexes with an obvious fluorescence generation, for the "turn-on" detection of T4 PNK.	thioflavin T	20-23	polynucleotide kinase 3'-phosphatase	Homo sapiens	126-129
26134353-5	2015	These then bound to ThT to form ThT/G-quadruplexes with an obvious fluorescence generation, for the "turn-on" detection of T4 PNK.	thioflavin T	32-35	polynucleotide kinase 3'-phosphatase	Homo sapiens	126-129
26083929-8	2015	Moreover, a temperature increase was observed to induce dissociation of SEPT3-GC dimers into monomers just preceding their reassembling into amyloid aggregates, as revealed by the Thioflavin-T fluorescence assays.	thioflavin T	180-192	septin 3	Homo sapiens	72-77
26175149-3	2015	Thioflavin T fluorescence assay as well as fluorescence and transmission microscopies revealed that upon lipid binding, fibril formation by apoA-I 1-83 is strongly inhibited, whereas the G26R mutant still retains the ability to form fibrils.	thioflavin T	0-12	apolipoprotein A1	Homo sapiens	140-146
25946560-7	2015	High concentrations of human serum albumin (HSA) and carboxyl-modified polystyrene nanoparticles lead to an elevated ThT signal, masking a possible fibril formation event.	thioflavin T	117-120	albumin	Homo sapiens	29-48
25934110-5	2015	The results showed that ginsenoside Rb1 and Rg1 inhibited obviously RCMkappa-CN fibrillation in both the initial rate and final level of ThT fluorescence.	thioflavin T	137-140	RB transcriptional corepressor 1	Homo sapiens	36-39
25934110-5	2015	The results showed that ginsenoside Rb1 and Rg1 inhibited obviously RCMkappa-CN fibrillation in both the initial rate and final level of ThT fluorescence.	thioflavin T	137-140	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	44-47
26063798-3	2015	When ultrasonication was used to accelerate the spontaneous fibrillation of beta2m at pH 2.0, the effects observed depended on ultrasonic power; although stronger ultrasonic power effectively accelerated fibrillation, excessively strong ultrasonic power decreased the amount of fibrils formed, as monitored by thioflavin T fluorescence.	thioflavin T	310-322	beta-2-microglobulin	Homo sapiens	76-82
25957407-7	2015	Cyclization of Bri and ABri resulted in production of biologically inert monomers that showed no propensity to assemble, whereas reduced ABri and reduced Bri aggregated forming thioflavin T-positive amyloid fibrils that lacked significant toxic activity.	thioflavin T	177-189	integral membrane protein 2B	Homo sapiens	15-18
26023729-4	2015	We have used Thioflavin T (ThT) fluorescence enhancement, circular dichroism spectroscopy (CD), coprecipitation, and transmission electron microscopy (TEM) to study the interaction of histone H1 with Abeta(1-42).	thioflavin T	13-25	H1.0 linker histone	Homo sapiens	184-194
26153461-3	2015	In the present study Forster resonance energy transfer (FRET) between the membrane fluorescent probe Laurdan as a donor and amyloid-specific dye Thioflavin T (ThT) as an acceptor was employed to explore the interactions of amyloid fibrils from apoA-I variants 1-83/G26R and 1-83/G26R/W@8 with the model membranes composed of phosphatidylcholine and its mixture with cholesterol.	thioflavin T	145-157	apolipoprotein A1	Homo sapiens	244-250
26173915-0	2015	Thioflavin T as an Efficient G-Quadruplex Inducer for the Highly Sensitive Detection of Thrombin Using a New Foster Resonance Energy Transfer System.	thioflavin T	0-12	coagulation factor II, thrombin	Homo sapiens	88-96
26173915-2	2015	A simple, label-free, and sensitive strategy for the detection of thrombin in buffer and in diluted serum was designed based on this new system using ThT as an efficient inducer of the G-quadruplex.	thioflavin T	150-153	coagulation factor II, thrombin	Homo sapiens	66-74
26173915-6	2015	However, in the presence of the target, the aptamer forms a G-quadruplex-thrombin complex first, followed by the intercalation of ThT into the G-quadruplex.	thioflavin T	130-133	coagulation factor II, thrombin	Homo sapiens	73-81
25754874-3	2015	It was found that, when dissolved in bulk solutions, Pep11 formed into beta-sheet structures and assembled into long filaments in several hours, as revealed by Thioflavin T fluorescence and transmission electron microscopy (TEM) morphology characterization, respectively.	thioflavin T	160-172	VPS29 retromer complex component	Homo sapiens	53-58
25634539-2	2015	We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of aminochrome determined by Western blot, transmission electron microscopy, circular dichroism, and thioflavin T fluorescence, suggesting a protective role of NQO1 by preventing the formation of SNCA oligomers in dopaminergic neurons.	thioflavin T	193-205	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	14-27
25634539-2	2015	We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of aminochrome determined by Western blot, transmission electron microscopy, circular dichroism, and thioflavin T fluorescence, suggesting a protective role of NQO1 by preventing the formation of SNCA oligomers in dopaminergic neurons.	thioflavin T	193-205	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	29-33
25634539-2	2015	We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of aminochrome determined by Western blot, transmission electron microscopy, circular dichroism, and thioflavin T fluorescence, suggesting a protective role of NQO1 by preventing the formation of SNCA oligomers in dopaminergic neurons.	thioflavin T	193-205	synuclein alpha	Rattus norvegicus	61-65
25483916-2	2015	In this paper, we developed a label-free and enzyme-free fluorescent biosensor based on target recycling and Thioflavin T (ThT) induced G-quadruplex formation for MXR7 (liver cancer related short gene) detection in human serum.	thioflavin T	109-121	glypican 3	Homo sapiens	163-167
25815792-5	2015	The ability of these peptides to depolymerize Abeta fibrils was also investigated experimentally using atomic force microscopy and fluorescence spectroscopy (Thioflavin T assay).	thioflavin T	158-170	amyloid beta precursor protein	Homo sapiens	46-51
25483916-2	2015	In this paper, we developed a label-free and enzyme-free fluorescent biosensor based on target recycling and Thioflavin T (ThT) induced G-quadruplex formation for MXR7 (liver cancer related short gene) detection in human serum.	thioflavin T	123-126	glypican 3	Homo sapiens	163-167
25659910-4	2015	Here we report real-time observation of alpha-syn fibril elongation on a glass surface, imaged by total internal reflection fluorescence microscopy using thioflavin T fluorescence.	thioflavin T	154-166	synuclein alpha	Homo sapiens	40-49
25407821-5	2015	By using Thioflavin T fluorescence assay, we found that B12H (0.3-3 muM) directly inhibited Abeta fibrils formation following co-incubation of B12H and Abeta1-40 at 37  C for 6 days in vitro.	thioflavin T	9-21	amyloid beta precursor protein	Homo sapiens	92-97
25461257-6	2015	A similar phenomenon was triggered after addition of Thioflavin S, which was shown to block BAG-1/BCL-2 interaction and to increase cell death, enforcing a prosurvival role of the BAG-1 protein in AML.	thioflavin T	53-65	BAG cochaperone 1	Homo sapiens	92-97
25498198-4	2015	The heparin nanoparticles were demonstrated to bind with Abeta through a variety of techniques including enzyme-linked immunosorbent assay, gel electrophoresis, and thioflavin T assay.	thioflavin T	165-177	amyloid beta precursor protein	Homo sapiens	57-62
25673873-4	2015	METHODS: in this study, we focused on Abeta amyloid fibrils and/or aggregation on the peripheral RBC from 50 subjects with AD and 50 healthy controls (HCs) through thioflavin T (ThT) staining followed by immunofluorescence assay to confirm the presence of Abeta amyloid fibrils and/or aggregation on the RBC.	thioflavin T	164-176	amyloid beta precursor protein	Homo sapiens	38-43
25673873-4	2015	METHODS: in this study, we focused on Abeta amyloid fibrils and/or aggregation on the peripheral RBC from 50 subjects with AD and 50 healthy controls (HCs) through thioflavin T (ThT) staining followed by immunofluorescence assay to confirm the presence of Abeta amyloid fibrils and/or aggregation on the RBC.	thioflavin T	178-181	amyloid beta precursor protein	Homo sapiens	38-43
25461257-6	2015	A similar phenomenon was triggered after addition of Thioflavin S, which was shown to block BAG-1/BCL-2 interaction and to increase cell death, enforcing a prosurvival role of the BAG-1 protein in AML.	thioflavin T	53-65	BCL2 apoptosis regulator	Homo sapiens	98-103
25461257-6	2015	A similar phenomenon was triggered after addition of Thioflavin S, which was shown to block BAG-1/BCL-2 interaction and to increase cell death, enforcing a prosurvival role of the BAG-1 protein in AML.	thioflavin T	53-65	BAG cochaperone 1	Homo sapiens	180-185
25461257-7	2015	Interestingly, synergic cytotoxic effects of doxorubicin, VP16 drugs, and ABT-737 compound were observed when Thioflavin S was coupled with these drugs.	thioflavin T	110-122	host cell factor C1	Homo sapiens	58-62
25609257-9	2015	ApoC-II D69K fibrils exhibited reduced thioflavin T binding capacity compared to that of fibrils formed by WT apoC-II and apoC-II KDDK.	thioflavin T	39-51	apolipoprotein C2	Homo sapiens	0-7
25446742-3	2015	In vitro generated alpha-syn oligomers and fibrils were verified using atomic force microscopy and the thioflavin T binding assay.	thioflavin T	103-115	synuclein, alpha	Mus musculus	19-28
25609918-7	2015	Molecules identified through ATPase assays are validated by thioflavin T aggregation assays in the presence of HSP70.	thioflavin T	60-72	dynein axonemal heavy chain 8	Homo sapiens	29-35
25404240-3	2015	A thioflavin T fluorescence assay showed that ZnPc(COONa)8 significantly inhibited Abeta fibril formation, increasing the lag time and dose-dependently decreasing the plateau level of fibril formation.	thioflavin T	2-14	amyloid beta precursor protein	Homo sapiens	83-88
25609918-7	2015	Molecules identified through ATPase assays are validated by thioflavin T aggregation assays in the presence of HSP70.	thioflavin T	60-72	heat shock protein family A (Hsp70) member 4	Homo sapiens	111-116
25347820-2	2014	Suppression of islet amyloid polypeptide (IAPP) fibril formation by compound 1 was demonstrated by thioflavin T fluorescence and atomic force microscopy.	thioflavin T	99-111	islet amyloid polypeptide	Rattus norvegicus	42-46
26510980-7	2015	Additionally, GFAP and Amylo-Glo labeling suggest that astrocytic hypertrophy is minimized in ThT-treated animals.	thioflavin T	94-97	glial fibrillary acidic protein	Mus musculus	14-18
25325557-2	2015	The definitive diagnosis is made postmortem, in part through the presence of amyloid-beta plaques in the brain tissue, which can be done with the small molecule thioflavin-T (ThT).	thioflavin T	161-173	amyloid beta precursor protein	Homo sapiens	77-89
25325557-2	2015	The definitive diagnosis is made postmortem, in part through the presence of amyloid-beta plaques in the brain tissue, which can be done with the small molecule thioflavin-T (ThT).	thioflavin T	175-178	amyloid beta precursor protein	Homo sapiens	77-89
25278441-8	2014	Thioflavin T staining indicated that homogeneous Abeta was achieved.	thioflavin T	0-12	amyloid beta (A4) precursor protein	Mus musculus	49-54
25139219-5	2014	GKN1 prevented amyloid aggregation and fibrils formation by inhibiting Abeta(1-40) polymerization, as evaluated by SDS-PAGE, thioflavin-T binding assay and gel filtration experiments.	thioflavin T	125-137	gastrokine 1	Homo sapiens	0-4
25217638-3	2014	By monitoring fibril formation using Thioflavin T fluorescence and far-UV CD spectroscopy, we have found that the aggregation of Abeta42 is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide.	thioflavin T	37-49	DnaJ heat shock protein family (Hsp40) member B6	Homo sapiens	152-158
25333939-5	2014	The amyloid-fibril-binding properties of L1 and L2 were investigated by fluorescence titrations and ThT competition assays.	thioflavin T	100-103	L1 cell adhesion molecule	Homo sapiens	41-50
25314129-4	2014	Thioflavin T assay showed that CAPE suppressed the amyloid fibril formation of TTR.	thioflavin T	0-12	transthyretin	Homo sapiens	79-82
24680925-7	2014	The PAS-ligand thioflavin-T (Th-T; 0.5-25muM), however, decreased cell adhesion and proliferation, on both uncoated and ACh-E coated plates, with less magnitude on AChE-coated plates.	thioflavin T	29-33	acetylcholinesterase	Mus musculus	164-168
25284680-3	2014	The aggregation mechanism of tau in the presence of inducers such as heparin, deciphered using probes such as thioflavin T/S fluorescence, light scattering, and electron microscopy assays, has been shown to conform to ligand-induced nucleation-dependent polymerization.	thioflavin T	110-122	microtubule associated protein tau	Homo sapiens	29-32
25172508-3	2014	Determination of the amyloidogenetic potential of these proteins by thioflavin T (ThT) method demonstrated that galectin-7 molecule incubated at pH 2.0 was capable of binding to the dye, but failed to form amyloid fibrils.	thioflavin T	68-80	galectin 7	Homo sapiens	112-122
25172508-3	2014	Determination of the amyloidogenetic potential of these proteins by thioflavin T (ThT) method demonstrated that galectin-7 molecule incubated at pH 2.0 was capable of binding to the dye, but failed to form amyloid fibrils.	thioflavin T	82-85	galectin 7	Homo sapiens	112-122
25118567-5	2014	While AGel alone undergoes sigmoidal transition to thioflavin T (ThT)-responsive fibrillar aggregates with clear lag phase, the presence of curcumin or emetine abolishes the lag phase and produces starkly different, noncytotoxic end products.	thioflavin T	51-63	gelsolin	Homo sapiens	6-10
25118567-5	2014	While AGel alone undergoes sigmoidal transition to thioflavin T (ThT)-responsive fibrillar aggregates with clear lag phase, the presence of curcumin or emetine abolishes the lag phase and produces starkly different, noncytotoxic end products.	thioflavin T	65-68	gelsolin	Homo sapiens	6-10
24680925-7	2014	The PAS-ligand thioflavin-T (Th-T; 0.5-25muM), however, decreased cell adhesion and proliferation, on both uncoated and ACh-E coated plates, with less magnitude on AChE-coated plates.	thioflavin T	15-27	acetylcholinesterase	Mus musculus	164-168
24680925-9	2014	On the other hand, binding of Th-T directly to the PAS affects both cell adherence and proliferation, with less magnitude in the presence of membrane-bound AChE.	thioflavin T	30-34	acetylcholinesterase	Mus musculus	156-160
24933520-4	2014	Incubation of SOD with glucose, methylglyoxal (MG) or both at 37C resulted in progressive hyperchromicity at 280nm, intrinsic fluorescence quenching at 310nm, decrease in negative ellipticity at 208nm, AGE-specific fluorescence enhancement in the wavelength range 400-480nm and Thioflavin T (ThT) fluorescence enhancement at 480nm (fibrillar state enhancement).	thioflavin T	278-290	superoxide dismutase 1	Homo sapiens	14-17
25245945-2	2014	Both Thioflavin T (ThT) and N-Methyl mesoporphyrin IX (NMM) become fluorescent in the presence of most G4, but thrombin-binding aptamer (TBA) has been reported as the only exception of the known G4-forming oligonucleotides when ThT is used as a high-throughput assay to identify G4 formation.	thioflavin T	19-22	coagulation factor II, thrombin	Homo sapiens	111-119
24933520-4	2014	Incubation of SOD with glucose, methylglyoxal (MG) or both at 37C resulted in progressive hyperchromicity at 280nm, intrinsic fluorescence quenching at 310nm, decrease in negative ellipticity at 208nm, AGE-specific fluorescence enhancement in the wavelength range 400-480nm and Thioflavin T (ThT) fluorescence enhancement at 480nm (fibrillar state enhancement).	thioflavin T	292-295	superoxide dismutase 1	Homo sapiens	14-17
24879532-5	2014	The inhibitory effect of these conjugates on Abeta amyloid fibril formation is reported using thioflavin T fluorescence assays and AFM observation.	thioflavin T	94-106	amyloid beta precursor protein	Homo sapiens	45-50
24835632-3	2014	Herein, we investigate the main pitfalls associated with the use of ThT-based assays to monitor the fibrillation of alpha-synuclein (alpha-syn), a protein linked to Parkinson"s disease and other alpha-synucleinopathies.	thioflavin T	68-71	synuclein alpha	Homo sapiens	116-131
24835632-3	2014	Herein, we investigate the main pitfalls associated with the use of ThT-based assays to monitor the fibrillation of alpha-synuclein (alpha-syn), a protein linked to Parkinson"s disease and other alpha-synucleinopathies.	thioflavin T	68-71	synuclein alpha	Homo sapiens	116-125
24835632-4	2014	We demonstrated for the first time that ThT interacts with alpha-syn disordered monomer and accelerates the protein fibrillation in vitro.	thioflavin T	40-43	synuclein alpha	Homo sapiens	59-68
24835632-6	2014	Interestingly, NMR experiments indicated that C-terminal domain of alpha-syn is the main region perturbed by ThT interaction, similarly to that found for the pesticide paraquat, a well-documented accelerator of alpha-syn fibrillation.	thioflavin T	109-112	synuclein alpha	Homo sapiens	67-76
24835632-6	2014	Interestingly, NMR experiments indicated that C-terminal domain of alpha-syn is the main region perturbed by ThT interaction, similarly to that found for the pesticide paraquat, a well-documented accelerator of alpha-syn fibrillation.	thioflavin T	109-112	synuclein alpha	Homo sapiens	211-220
24835632-7	2014	Moreover, we demonstrated that certain potent inhibitors of alpha-syn fibrillation, such as oxidized catecholamines and polyphenols, undergo spontaneous oxidation in aqueous solution, generating compounds that strongly quench ThT fluorescence.	thioflavin T	226-229	synuclein alpha	Homo sapiens	60-69
24834989-2	2014	Moreover, this G-rich sequence binding to the thioflavin T (ThT) dye can be applied in real-time fluorescent detection of TdT activity.	thioflavin T	46-58	DNA nucleotidylexotransferase	Homo sapiens	122-125
24834989-2	2014	Moreover, this G-rich sequence binding to the thioflavin T (ThT) dye can be applied in real-time fluorescent detection of TdT activity.	thioflavin T	60-63	DNA nucleotidylexotransferase	Homo sapiens	122-125
24602872-5	2014	Thioflavin T fluorescence and dynamic light scattering measurements and transmission electron microscopy analysis confirm that recombinant medin assembles into amyloid-like fibrils over a 48-h period.	thioflavin T	0-12	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	139-144
24471790-3	2014	Here, we show by a combination of independent techniques including electron microscopy, Thioflavin T fluorescence, and circular dichroism that GAPR-1 has the capability to form amyloid-like fibrils in the presence of liposomes containing negatively charged lipids.	thioflavin T	88-100	GLI pathogenesis related 2	Homo sapiens	143-149
24988354-2	2014	In this work, we characterize the aggregation process of human insulin at acidic pH in the presence of sulfate ions using a combination of Thioflavin T fluorescence, dynamic light scattering, size exclusion chromatography, Fourier transform infrared spectroscopy, and transmission electron microscopy.	thioflavin T	139-151	insulin	Homo sapiens	63-70
24480422-4	2014	In vitro generated alpha-syn oligomers and fibrils were characterized using atomic force microscopy and the thioflavin T binding assay.	thioflavin T	108-120	synuclein, alpha	Mus musculus	19-28
24717291-3	2014	Fluorescent imaging demonstrated that 2 and 8 clearly stained thioflavin-S positive Abeta plaques in the brain sections of Tg2576 transgenic mice.	thioflavin T	62-74	amyloid beta (A4) precursor protein	Mus musculus	84-89
24594816-0	2014	Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection.	thioflavin T	67-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	134-142
24661268-6	2014	Thioflavin T kinetics fluorescence assays demonstrate that mPPCs suppress Abeta fibrillogenesis.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	74-79
24594816-2	2014	In this paper, we developed a label-free fluorescent biosensor based on nuclease assisted target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection in saliva.	thioflavin T	111-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	178-186
24281246-5	2014	Thioflavin S-stained amyloid plaque intensity was reduced up to 60% by CTB-MBP incubation with human AD and 3xTgAD mice brain sections ex vivo.	thioflavin T	0-12	phosphate cytidylyltransferase 1B, choline	Homo sapiens	71-74
24281246-5	2014	Thioflavin S-stained amyloid plaque intensity was reduced up to 60% by CTB-MBP incubation with human AD and 3xTgAD mice brain sections ex vivo.	thioflavin T	0-12	myelin basic protein	Homo sapiens	75-78
24488624-3	2014	The effect of the ligands on IAPP amyloid fibril formation was evaluated with the thioflavin T (ThT) fluorescence-based assay.	thioflavin T	82-94	islet amyloid polypeptide	Homo sapiens	29-33
24112789-4	2014	Here, we show that Abeta and gramicidin form aggregates enriched in beta-sheet structures using electron microscopy, and Thioflavin and Congo Red staining techniques.	thioflavin T	121-131	amyloid beta precursor protein	Homo sapiens	19-24
24488624-3	2014	The effect of the ligands on IAPP amyloid fibril formation was evaluated with the thioflavin T (ThT) fluorescence-based assay.	thioflavin T	96-99	islet amyloid polypeptide	Homo sapiens	29-33
23981668-8	2014	The results of further dot blot assays, thioflavin T fluorescence assays, and electron microscopy imaging experiments, indicated that the N-terminal synthetic peptide AChE7-20 had nearly the same ability as AChE with regard to triggering Abeta aggregation and deposition.	thioflavin T	40-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171
24460028-3	2014	In this work the effect of the air-water interface (AWI) on alpha-Syn aggregation is investigated by means of thioflavin T binding measurements, dynamic light scattering, size-exclusion chromatography, electron microscopy, and atomic force microscopy.	thioflavin T	110-122	synuclein alpha	Homo sapiens	60-69
24422526-3	2014	Herein, we demonstrated that glabridin (Glab), a prenylated isoflavan isolated from Glycyrrhiza glabra L., inhibited aggregation of TTR in a thioflavin assay.	thioflavin T	141-151	transthyretin	Homo sapiens	132-135
25506055-8	2014	Compared with the control, more and longer fibrils of Abeta in the presence of geniposide were observed under electron microscope though the fibrils became less sensitive to thioflavin T staining.	thioflavin T	174-186	amyloid beta precursor protein	Homo sapiens	54-59
24440699-5	2014	All SAA1 isoforms adopted alpha-helix structures at 4 C, but were unstructured at 37 C. Heparin-induced amyloid fibril formation of SAA1 was observed at 37 C, as evidenced by the increased thioflavin T (ThT) fluorescence and beta-sheet structure formation.	thioflavin T	189-201	serum amyloid A1	Homo sapiens	4-8
24440699-5	2014	All SAA1 isoforms adopted alpha-helix structures at 4 C, but were unstructured at 37 C. Heparin-induced amyloid fibril formation of SAA1 was observed at 37 C, as evidenced by the increased thioflavin T (ThT) fluorescence and beta-sheet structure formation.	thioflavin T	189-201	serum amyloid A1	Homo sapiens	132-136
24440699-5	2014	All SAA1 isoforms adopted alpha-helix structures at 4 C, but were unstructured at 37 C. Heparin-induced amyloid fibril formation of SAA1 was observed at 37 C, as evidenced by the increased thioflavin T (ThT) fluorescence and beta-sheet structure formation.	thioflavin T	203-206	serum amyloid A1	Homo sapiens	4-8
24440699-5	2014	All SAA1 isoforms adopted alpha-helix structures at 4 C, but were unstructured at 37 C. Heparin-induced amyloid fibril formation of SAA1 was observed at 37 C, as evidenced by the increased thioflavin T (ThT) fluorescence and beta-sheet structure formation.	thioflavin T	203-206	serum amyloid A1	Homo sapiens	132-136
24239554-0	2014	Interaction of thioflavin T with amyloid fibrils of apolipoprotein A-I N-terminal fragment: resonance energy transfer study.	thioflavin T	15-27	apolipoprotein A1	Homo sapiens	52-70
24304283-5	2014	Results obtained from both molecular simulations and surface plasmon resonance experiments reveal a strong binding of D3 and RD2 to Abeta, leading to a significant reduction in the amount of beta structures in both monomer and fibril, which was also demonstrated in Thioflavin T assays.	thioflavin T	266-278	peripherin 2	Homo sapiens	125-128
24170094-1	2014	The fluorescence response of the Thioflavin-T (ThT) dye and derivatives has become the standard tool for detecting beta-amyloid aggregates (Abeta) in solution.	thioflavin T	33-45	amyloid beta precursor protein	Homo sapiens	140-145
24170094-1	2014	The fluorescence response of the Thioflavin-T (ThT) dye and derivatives has become the standard tool for detecting beta-amyloid aggregates (Abeta) in solution.	thioflavin T	47-50	amyloid beta precursor protein	Homo sapiens	140-145
24296542-3	2014	Tissue amyloid-beta was evaluated using the monoclonal antibody 4G8, thioflavin S and Bielschowsky silver stain.	thioflavin T	69-81	amyloid beta precursor protein	Homo sapiens	7-19
24053224-4	2013	As measured by a Thioflavin-T based fibrillization assay, there was an earlier onset of aggregation when alpha-synuclein oligomers were added to monomeric alpha-synuclein.	thioflavin T	17-29	synuclein, alpha	Mus musculus	105-120
24053224-4	2013	As measured by a Thioflavin-T based fibrillization assay, there was an earlier onset of aggregation when alpha-synuclein oligomers were added to monomeric alpha-synuclein.	thioflavin T	17-29	synuclein, alpha	Mus musculus	155-170
24384760-1	2013	In order to compare the density functional theory (DFT) and the method with the molecular valence connectivity index of the 3rd order (3chiv) in the estimation of stability constants log beta2, we used copper(II) complexes with thioflavin-based intercalation compounds designed for application in Alzheimer"s disease.	thioflavin T	228-238	ATPase H+ transporting V0 subunit a2	Homo sapiens	187-192
24157371-3	2013	In this study we have shown, using in vitro thioflavin T assays and transmission electron microscopy, that grape seed extract inhibits fibril formation of kappa-casein (kappa-CN), a milk protein which forms amyloid fibrils spontaneously under physiological conditions.	thioflavin T	44-56	casein kappa	Homo sapiens	155-167
24157371-3	2013	In this study we have shown, using in vitro thioflavin T assays and transmission electron microscopy, that grape seed extract inhibits fibril formation of kappa-casein (kappa-CN), a milk protein which forms amyloid fibrils spontaneously under physiological conditions.	thioflavin T	44-56	casein kappa	Homo sapiens	169-177
23963844-6	2013	The time-dependent loss of thioflavin T fluorescence that we interpreted previously as disaggregation is due to increased adsorption of Abeta amyloid to the surfaces of multiwell plates and Eppendorf tubes in the presence of biological extracts.	thioflavin T	27-39	amyloid beta precursor protein	Homo sapiens	136-141
24239554-3	2014	In the present study Forster resonance energy transfer between tryptophan as a donor and Thioflavin T as an acceptor was employed to obtain structural information on the amyloid fibrils formed by apoA-I variant 1-83/G26R/W@8.	thioflavin T	89-101	apolipoprotein A1	Homo sapiens	196-202
24239554-5	2014	A beta-strand-loop-beta-strand structural model of 1-83/G26R/W@8 apoA-I fibrils has been proposed, with potential ThT binding sites located in the solvent-exposed grooves of the N-terminal beta-sheet layer.	thioflavin T	114-117	apolipoprotein A1	Homo sapiens	65-71
24243599-3	2013	In this paper, we have investigated the ability of covalently linked long-chain fatty acids in modulating the self-assembly of an aromatic amino acid-rich highly amyloidogenic sequence derived from the amino acid region 59-71 of human beta2-microglobulin by thioflavin T (ThT) fluorescence microscopy, circular dichroism, and fluorescence spectroscopy.	thioflavin T	258-270	beta-2-microglobulin	Homo sapiens	235-254
24243599-3	2013	In this paper, we have investigated the ability of covalently linked long-chain fatty acids in modulating the self-assembly of an aromatic amino acid-rich highly amyloidogenic sequence derived from the amino acid region 59-71 of human beta2-microglobulin by thioflavin T (ThT) fluorescence microscopy, circular dichroism, and fluorescence spectroscopy.	thioflavin T	272-275	beta-2-microglobulin	Homo sapiens	235-254
24109600-8	2013	Sti1-inducible foci are perinuclear and contain proteins that are bound by the amyloid indicator dye thioflavin-T.	thioflavin T	101-113	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	0-4
24048738-0	2013	Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.	thioflavin T	21-33	BAG cochaperone 1	Homo sapiens	65-70
24048738-0	2013	Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.	thioflavin T	21-33	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	113-117
24048738-2	2013	Thioflavin S (NSC71948)-a mixture of compounds resulting from the methylation and sulfonation of primulin base-has been shown to dose-dependently inhibit the interaction between BAG-1 and Hsc70 in vitro.	thioflavin T	0-12	BAG cochaperone 1	Homo sapiens	178-183
24048738-2	2013	Thioflavin S (NSC71948)-a mixture of compounds resulting from the methylation and sulfonation of primulin base-has been shown to dose-dependently inhibit the interaction between BAG-1 and Hsc70 in vitro.	thioflavin T	0-12	heat shock protein family A (Hsp70) member 8	Homo sapiens	188-193
24048738-3	2013	In human breast cancer cell lines, with high BAG-1 expression levels, Thioflavin S reduces the binding of BAG-1 to Hsc70, Hsp70, or CRAF and decreases proliferation and viability.	thioflavin T	70-82	BAG cochaperone 1	Homo sapiens	45-50
24048738-3	2013	In human breast cancer cell lines, with high BAG-1 expression levels, Thioflavin S reduces the binding of BAG-1 to Hsc70, Hsp70, or CRAF and decreases proliferation and viability.	thioflavin T	70-82	BAG cochaperone 1	Homo sapiens	106-111
24048738-3	2013	In human breast cancer cell lines, with high BAG-1 expression levels, Thioflavin S reduces the binding of BAG-1 to Hsc70, Hsp70, or CRAF and decreases proliferation and viability.	thioflavin T	70-82	heat shock protein family A (Hsp70) member 8	Homo sapiens	115-120
24048738-3	2013	In human breast cancer cell lines, with high BAG-1 expression levels, Thioflavin S reduces the binding of BAG-1 to Hsc70, Hsp70, or CRAF and decreases proliferation and viability.	thioflavin T	70-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	122-127
24048738-3	2013	In human breast cancer cell lines, with high BAG-1 expression levels, Thioflavin S reduces the binding of BAG-1 to Hsc70, Hsp70, or CRAF and decreases proliferation and viability.	thioflavin T	70-82	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	132-136
23974296-3	2013	We observed the ability of the water-soluble murine amylin to aggregate in water resulting in an insoluble material with Thioflavin T binding properties.	thioflavin T	121-133	islet amyloid polypeptide	Mus musculus	52-58
23986449-3	2013	Russell"s viper venom (RVV) contains protein(s) that destabilize Abeta aggregates as revealed from the thioflavin T assay.	thioflavin T	103-115	amyloid beta precursor protein	Homo sapiens	65-70
23777711-5	2013	The increase in Thioflavin T (ThT) and anilinonaphthalene-8-sulfonic acid (ANS) fluorescent intensities and Congo red absorbance were inhibited by simultaneous incubation of various concentrations of apigenin with insulin, in a dose-dependent manner.	thioflavin T	16-28	insulin	Homo sapiens	214-221
23913715-5	2013	Circular dichroism and thioflavin T(S) assays showed that secondary structures of Abeta and alphaS assemblies inhibited by antiparkinsonian agents were statistical coil state and that their seeding activities had disappeared.	thioflavin T	23-35	amyloid beta precursor protein	Homo sapiens	82-87
24970188-4	2013	The thioflavine T (ThT) fluorescence assay studies provide evidence that early-phase misfolded alpha-synuclein forms are affected by rotenone and that the fibrillation process is accelerated.	thioflavin T	4-17	synuclein alpha	Homo sapiens	95-110
24970188-4	2013	The thioflavine T (ThT) fluorescence assay studies provide evidence that early-phase misfolded alpha-synuclein forms are affected by rotenone and that the fibrillation process is accelerated.	thioflavin T	19-22	synuclein alpha	Homo sapiens	95-110
24098548-7	2013	As revealed by thioflavin T binding assays, Sarkosyl-insoluble SDS-PAGE, and transmission electron microscopy, full-length human PDI remarkably inhibits both steps of nucleation and elongation of Tau244-372 fibrillization in a concentration-dependent manner.	thioflavin T	15-27	prolyl 4-hydroxylase subunit beta	Homo sapiens	129-132
23861388-6	2013	In agreement, Ca(2+) decreases SOD1 critical concentration and nucleation time during aggregation kinetics, as evidenced by thioflavin T fluorescence emission.	thioflavin T	124-136	superoxide dismutase 1	Homo sapiens	31-35
23715664-5	2013	In the present study, we have analyzed the expression of GMF and its association with APs and NFTs in the entorhinal cortex of AD brains by using immunohistochemistry combined with thioflavin-S fluorescence labeling methods.	thioflavin T	181-191	glia maturation factor beta	Homo sapiens	57-60
23885714-6	2013	Thioflavin-S-negative neuronal and glial inclusions of patients with FTDP-17 were robustly AC-K280 reactive.	thioflavin T	0-12	microtubule associated protein tau	Homo sapiens	69-76
23645685-1	2013	The interaction at neutral pH between wild-type and a variant form (R3A) of the amyloid fibril-forming protein beta2-microglobulin (beta2m) and the molecular chaperone alphaB-crystallin was investigated by thioflavin T fluorescence, NMR spectroscopy, and mass spectrometry.	thioflavin T	206-218	beta-2-microglobulin	Homo sapiens	111-130
23541553-2	2013	Increasing the concentration of either GA or ferulic acid (FA) up to 50 mM results in cyt c aggregation as confirmed by shift in Congo red, increase thioflavin T, decrease ANS and Trp fluorescence.	thioflavin T	149-161	cytochrome c, somatic	Homo sapiens	86-91
24003261-3	2013	The assay uses thioflavin-T as a probe, which binds to the peripheral anionic site of AChE and yields an increase in fluorescent signal.	thioflavin T	15-27	acetylcholinesterase	Mus musculus	86-90
23645685-1	2013	The interaction at neutral pH between wild-type and a variant form (R3A) of the amyloid fibril-forming protein beta2-microglobulin (beta2m) and the molecular chaperone alphaB-crystallin was investigated by thioflavin T fluorescence, NMR spectroscopy, and mass spectrometry.	thioflavin T	206-218	beta-2-microglobulin	Homo sapiens	132-138
23470163-5	2013	Notably, administration of the B1R antagonist, R715, to 8-month-old Tg-SwDI mice for 8 weeks resulted in higher Abeta40 levels and increased thioflavin S-positive fibrillar Abeta deposition.	thioflavin T	141-153	bradykinin receptor, beta 1	Mus musculus	31-34
23584594-6	2013	The results of thioflavin T and Congo red assays suggest the existence of a significant quantity of amyloid-like entities in the sample of reduced glycated insulin adduct.	thioflavin T	15-27	insulin	Homo sapiens	156-163
23652332-8	2013	Zn(2+) binding to Abeta42 almost completely suppressed Abeta42 fibrillization, which could be significantly restored by SelP-H and SelM", as observed by thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM).	thioflavin T	167-170	selectin P	Homo sapiens	120-124
23652332-8	2013	Zn(2+) binding to Abeta42 almost completely suppressed Abeta42 fibrillization, which could be significantly restored by SelP-H and SelM", as observed by thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM).	thioflavin T	167-170	selenoprotein M	Homo sapiens	131-136
23696796-6	2013	We report that both IVIG and pAbs-Abeta specifically bound to Abeta and inhibited its aggregation in a dose-dependent manner as measured by Thioflavin T assay.	thioflavin T	140-152	amyloid beta precursor protein	Homo sapiens	34-39
23696796-6	2013	We report that both IVIG and pAbs-Abeta specifically bound to Abeta and inhibited its aggregation in a dose-dependent manner as measured by Thioflavin T assay.	thioflavin T	140-152	amyloid beta precursor protein	Homo sapiens	62-67
23614719-7	2013	Thioflavin T measurements and immunoblotting indicated different structural properties for the different Abeta oligomers.	thioflavin T	0-12	amyloid beta (A4) precursor protein	Mus musculus	105-110
23510371-14	2013	Alanine scanning mutagenesis revealed that amino acids K54, R55, G56, and K59 within MBP1-64 are important for both Abeta binding and inhibition of fibril assembly as assessed by solid phase binding, thioflavin T binding and fluorescence, and transmission electron microscopy studies.	thioflavin T	200-212	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	85-89
23360549-5	2013	In transmission electron microscopy, optimized thioflavin T and cell survival assays, CP-2 inhibits the formation of Abeta aggregates, entirely disassembles preformed aggregated and fibrillar Abeta, and protects rat pheochromocytoma PC12 cells from Abeta toxicity, without inducing any toxicity by itself.	thioflavin T	47-59	cathepsin L	Rattus norvegicus	86-90
23435553-0	2013	Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer"s disease.	thioflavin T	36-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
23509974-5	2013	Staining of Abeta plaques was confirmed via staining of the same sections with the fluorescent amyloid binding dye Thioflavin S.	thioflavin T	115-127	amyloid beta (A4) precursor protein	Mus musculus	12-17
23333843-3	2013	Both alpha-syn oligomers and its fibrils were firstly characterized using atomic force microscopy and the thioflavin T binding assay.	thioflavin T	106-118	synuclein alpha	Homo sapiens	5-14
23762946-3	2010	During assay development, we discovered that trace components in the dye mixtures thioflavine S and primuline were potent inhibitors of the NS3 helicase.	thioflavin T	82-95	KRAS proto-oncogene, GTPase	Homo sapiens	140-143
23339420-5	2013	Equal molar ratios of PGG to IAPP substantially reduced the ability of IAPP to bind thioflavin T.	thioflavin T	84-96	islet amyloid polypeptide	Rattus norvegicus	29-33
23467355-5	2013	We show that ABCA7 loss doubled insoluble Abeta levels and thioflavine-S-positive plaques in the brain.	thioflavin T	59-70	ATP-binding cassette, sub-family A (ABC1), member 7	Mus musculus	13-18
23339420-5	2013	Equal molar ratios of PGG to IAPP substantially reduced the ability of IAPP to bind thioflavin T.	thioflavin T	84-96	islet amyloid polypeptide	Rattus norvegicus	71-75
22993064-6	2013	We show that these chaperone proteins suppress the increase in thioflavin T fluorescence associated with SOD1 aggregation, primarily through inhibiting aggregate growth, not the lag phase in which nuclei are formed.	thioflavin T	63-75	superoxide dismutase 1	Homo sapiens	105-109
22035352-7	2012	The distribution of GMF-immunoreactive cells in and around Thioflavin-S stained APs and NFTs suggests involvement of GMF in inflammatory responses through reactive glia and a role of GMF in AD pathology.	thioflavin T	59-71	glia maturation factor beta	Homo sapiens	20-23
23262353-7	2013	In addition, the elk PrP(127-147) peptide is unique in its ability to enhance Thioflavin T fluorescence and its ability to modulate neuronal ion channel conductances.	thioflavin T	78-90	PRP@	Bos taurus	21-24
22976818-3	2013	Importantly, this probe, compared with the well known amyloid-staining compound thioflavin T (ThT), is more sensitive to Abeta oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer"s disease.	thioflavin T	80-92	amyloid beta precursor protein	Homo sapiens	121-126
22976818-3	2013	Importantly, this probe, compared with the well known amyloid-staining compound thioflavin T (ThT), is more sensitive to Abeta oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer"s disease.	thioflavin T	94-97	amyloid beta precursor protein	Homo sapiens	121-126
22387586-7	2013	Expression of cardiac fgl2 was correlated with no-reflow size of rats with acute MI/R, which was detected and calculated by thioflavin S staining.	thioflavin T	124-136	fibrinogen-like 2	Rattus norvegicus	22-26
23256221-9	2004	N-methyl-[(11)C]-2-(4"-methylaminophenyl)-6-hydroxybenzothiasole, an Abeta-binding compound based on a series of neutral thioflavin-T derivatives, was radiolabeled with the positron-emitting radionuclide (11)C ([(11)C]6-OH-BTA-1 or [(11)C]PIB).	thioflavin T	121-133	amyloid beta precursor protein	Homo sapiens	69-74
22634517-3	2012	Thioflavin-T fluorescence studies revealed that HCTL markedly enhanced the quantity of insulin fibril formation in both agitating and non-agitating systems.	thioflavin T	0-12	insulin	Homo sapiens	87-94
23022543-10	2013	Finally, Thioflavin T, a marker of extended beta-sheet structures present in amyloid fibers, binds to adsorbed insulin after 30-40 min.	thioflavin T	9-21	insulin	Homo sapiens	111-118
23053135-9	2013	Increased tau pathology in FTLD-C9ORF72 was assessed with thioflavin-S fluorescent microscopy-based neurofibrillary tangle counts and with image analysis of tau burden in temporal cortex and hippocampus.	thioflavin T	58-70	microtubule associated protein tau	Homo sapiens	10-13
23053135-9	2013	Increased tau pathology in FTLD-C9ORF72 was assessed with thioflavin-S fluorescent microscopy-based neurofibrillary tangle counts and with image analysis of tau burden in temporal cortex and hippocampus.	thioflavin T	58-70	C9orf72-SMCR8 complex subunit	Homo sapiens	32-39
23325240-5	2013	Moreover, unlike tau pathology that spontaneously develops in old PS19 mice, the pff-induced tau inclusions more closely resembled AD NFTs because they were Thioflavin S positive, acetylated, and more resistant to proteinase K digestion.	thioflavin T	157-169	microtubule associated protein tau	Homo sapiens	93-96
23234567-4	2013	In the absence of preformed [KR] amyloid seeds, bovine insulin agitated at 60  C converts into chiral amyloid superstructures exhibiting negative extrinsic Cotton effect in bound thioflavin T.	thioflavin T	179-191	insulin	Bos taurus	55-62
23124365-8	2013	The demonstration that pathological TDP-43 can be amyloidogenic in situ suggests the following conclusions: (1) the conformational changes associated with TDP-43 aggregation are more complex than previously thought; (2) Thioflavin-S positive SLI may be composed primarily of filamentous ultrastructures.	thioflavin T	220-232	TAR DNA binding protein	Homo sapiens	36-42
23090025-2	2013	Conformational changes on ovalbumin at various concentrations of glyoxal, ethylene glycol (EG) and polyethylene glycol-400 (PEG-400) were investigated by fluorescence spectroscopy, circular dichroism, attenuated total reflection Fourier transform infra red spectroscopy, 8-anilino-1-naphthalenesulfonic acid and thioflavin T assay.	thioflavin T	312-324	ovalbumin (SERPINB14)	Gallus gallus	26-35
22981725-10	2012	When Abeta(1-40 or 1-42) was co-incubated with RES (50muM), the thioflavin T fluorescence of the mixture was weakened, and the number and length of amyloid fibrils were decreased.	thioflavin T	64-76	amyloid beta precursor protein	Homo sapiens	5-10
22981725-10	2012	When Abeta(1-40 or 1-42) was co-incubated with RES (50muM), the thioflavin T fluorescence of the mixture was weakened, and the number and length of amyloid fibrils were decreased.	thioflavin T	64-76	latexin	Homo sapiens	54-57
22998665-9	2012	Using (19)F NMR, we show that thioflavin T strongly competes with EGCG for binding sites on IAPP fibers.	thioflavin T	30-42	islet amyloid polypeptide	Homo sapiens	92-96
22035352-7	2012	The distribution of GMF-immunoreactive cells in and around Thioflavin-S stained APs and NFTs suggests involvement of GMF in inflammatory responses through reactive glia and a role of GMF in AD pathology.	thioflavin T	59-71	glia maturation factor beta	Homo sapiens	117-120
22035352-7	2012	The distribution of GMF-immunoreactive cells in and around Thioflavin-S stained APs and NFTs suggests involvement of GMF in inflammatory responses through reactive glia and a role of GMF in AD pathology.	thioflavin T	59-71	glia maturation factor beta	Homo sapiens	117-120
22799493-3	2012	The amyloidogenic activity of the synthesized Abeta was confirmed via thioflavin T assay, transmission electron microscopic analysis and electrophoresis.	thioflavin T	70-82	amyloid beta precursor protein	Homo sapiens	46-51
22913627-4	2012	Thioflavin-T fluorescence and MTT assays were used to measure its ability to block Abeta(1-42) -induced aggregation and reduction in cell viability.	thioflavin T	0-12	amyloid beta precursor protein	Rattus norvegicus	83-88
22715097-5	2012	Full-length p53 aggregated into amyloid-like species that bound thioflavin T.	thioflavin T	64-76	tumor protein p53	Homo sapiens	12-15
22206987-11	2012	Thioflavin T binding assays, together with experiments using a p-cyanophenylalanine (p-cyanoPhe) variant of human IAPP, show that the designed S20K mutant inhibits amyloid formation by human IAPP.	thioflavin T	0-12	islet amyloid polypeptide	Homo sapiens	114-118
22206987-11	2012	Thioflavin T binding assays, together with experiments using a p-cyanophenylalanine (p-cyanoPhe) variant of human IAPP, show that the designed S20K mutant inhibits amyloid formation by human IAPP.	thioflavin T	0-12	islet amyloid polypeptide	Homo sapiens	191-195
22817896-5	2012	The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX.	thioflavin T	68-71	receptor interacting serine/threonine kinase 1	Homo sapiens	15-19
22789706-2	2012	To identify ligands having high binding potency toward aggregated alpha-synuclein, we synthesized a series of phenothiazine derivatives and assessed their binding affinity to recombinant alpha-synuclein fibrils using a fluorescent thioflavin T competition assay.	thioflavin T	231-243	synuclein alpha	Homo sapiens	66-81
22789706-2	2012	To identify ligands having high binding potency toward aggregated alpha-synuclein, we synthesized a series of phenothiazine derivatives and assessed their binding affinity to recombinant alpha-synuclein fibrils using a fluorescent thioflavin T competition assay.	thioflavin T	231-243	synuclein alpha	Homo sapiens	187-202
22817896-5	2012	The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX.	thioflavin T	68-71	receptor interacting serine/threonine kinase 3	Homo sapiens	20-24
22817896-5	2012	The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX.	thioflavin T	168-171	receptor interacting serine/threonine kinase 1	Homo sapiens	15-19
22817896-5	2012	The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX.	thioflavin T	168-171	receptor interacting serine/threonine kinase 3	Homo sapiens	20-24
22266679-1	2012	Using human insulin, we report for the first time, the evaluation of fluorescence lifetime of an extrinsically added fluorogenic dye, Thioflavin T (ThT), as a more sensitive and convenient method for the assessment of fibrillation in the pre-fibrillar regime.	thioflavin T	134-146	insulin	Homo sapiens	12-19
22978166-3	2012	Thioflavin T binding assay revealed an enhanced fibrillization of the recombinant human PrP after redox process.	thioflavin T	0-12	prion protein	Homo sapiens	88-91
22119572-9	2012	Synchrotron radiation-circular dichroism and, Congo red and thioflavin-T dye-binding experiments suggested that transferrin aggregation in solution does not involve major structural changes to the protein or formation of classical beta-sheet amyloid structures.	thioflavin T	60-72	transferrin	Homo sapiens	112-123
22266679-1	2012	Using human insulin, we report for the first time, the evaluation of fluorescence lifetime of an extrinsically added fluorogenic dye, Thioflavin T (ThT), as a more sensitive and convenient method for the assessment of fibrillation in the pre-fibrillar regime.	thioflavin T	148-151	insulin	Homo sapiens	12-19
22754299-4	2012	The aggregation rate was determined by the Thioflavin T (ThT) assay, in which Abeta-40 Y10F populated an ensemble of folded conformations much quicker and stronger than the wild type Abeta.	thioflavin T	43-55	amyloid beta precursor protein	Homo sapiens	78-83
22281499-4	2012	We report that C-peptide then modulates the insulin aggregation lag time and profoundly changes the fibril appearance, to rounded clumps of short fibrils, which, however, still are Thioflavine T-positive.	thioflavin T	181-194	insulin	Homo sapiens	15-24
22285571-3	2012	Here we take a ligand-based quantitative structure-activity relationship approach to identify descriptors of binding affinity and selectivity for a series of 50 closely related benzothiazole derivatives reported to displace Thioflavin T fluorescent probe from synthetic aggregates composed of beta-amyloid peptide and insulin.	thioflavin T	224-236	amyloid beta precursor protein	Homo sapiens	293-313
22285571-3	2012	Here we take a ligand-based quantitative structure-activity relationship approach to identify descriptors of binding affinity and selectivity for a series of 50 closely related benzothiazole derivatives reported to displace Thioflavin T fluorescent probe from synthetic aggregates composed of beta-amyloid peptide and insulin.	thioflavin T	224-236	insulin	Homo sapiens	318-325
22031526-1	2012	Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T.	thioflavin T	267-279	prion protein	Homo sapiens	102-105
22031526-1	2012	Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T.	thioflavin T	267-279	prion protein	Homo sapiens	166-169
22754299-4	2012	The aggregation rate was determined by the Thioflavin T (ThT) assay, in which Abeta-40 Y10F populated an ensemble of folded conformations much quicker and stronger than the wild type Abeta.	thioflavin T	57-60	amyloid beta precursor protein	Homo sapiens	78-83
22059381-4	2011	In this study, the effects of these major coffee components, as well as dihydrocaffeic acid (DHCA) (a major metabolite of CGA and CA), on the amyloidogenicity of hIAPP were investigated by thioflavin-T based fluorescence emission, transmission electronic microscopy, circular dichroism, light-induced cross-linking, dynamic light scattering, and MTT-based cell viability assays.	thioflavin T	189-201	islet amyloid polypeptide	Homo sapiens	162-167
22728896-8	2012	Our results suggest that MQ induces changes in the aggregation kinetics of Abeta producing variations in the nucleation phase (Abeta: k1 = 2.7 +- 0.4 x 10-3 s-1 MQ: k1 = 8.3 +- 0.6 x 10-3 s-1) and altering Thioflavin T insertion in beta-sheets.	thioflavin T	206-216	amyloid beta precursor protein	Rattus norvegicus	75-80
22728896-8	2012	Our results suggest that MQ induces changes in the aggregation kinetics of Abeta producing variations in the nucleation phase (Abeta: k1 = 2.7 +- 0.4 x 10-3 s-1 MQ: k1 = 8.3 +- 0.6 x 10-3 s-1) and altering Thioflavin T insertion in beta-sheets.	thioflavin T	206-216	amyloid beta precursor protein	Rattus norvegicus	127-132
22083646-4	2012	In the current study, we demonstrated that the same selected substances also decrease the fluorescence signal of ThT bound to insulin fibrils already at submicromolar or micromolar concentrations.	thioflavin T	113-116	insulin	Homo sapiens	126-133
22986484-4	2012	METHODS: The formation of alpha-synuclein amyloid species was assessed by thioflavin-T assay and atomic force microscopy was employed to confirm their morphology.	thioflavin T	74-86	synuclein alpha	Homo sapiens	26-41
22312444-8	2012	Relocalization of tau from axons to somatodendritic compartments and propagation of tauopathy to regions outside of the EC correlated with mature tangle formation in neurons in the EC as revealed by thioflavin-S staining.	thioflavin T	199-211	microtubule associated protein tau	Homo sapiens	18-21
21942925-2	2011	However, here we show that the nonpathogenic murine SAA2.2 spontaneously forms marginally stable amyloid fibrils at 37  C that exhibit cross-beta structure, binding to thioflavin T, and fibrillation by a nucleation-dependent seeding mechanism.	thioflavin T	168-180	serum amyloid A 2	Mus musculus	52-56
21986202-2	2011	We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on alpha-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques.	thioflavin T	199-211	synuclein alpha	Homo sapiens	147-156
22004604-3	2011	The interaction was also marked when unheated lysozyme was mixed with N-ovalbumin preheated at 72  C. Moreover, the mixture rapidly formed fibrous precipitates, which were positive for thioflavin T fluorescent emission, a marker for the amyloid fibril formation.	thioflavin T	185-197	lysozyme	Homo sapiens	46-54
22220313-8	2004	Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes.	thioflavin T	108-120	amyloid beta precursor protein	Homo sapiens	23-28
22220317-8	2004	Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes.	thioflavin T	108-120	amyloid beta precursor protein	Homo sapiens	23-28
22220319-9	2004	Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes.	thioflavin T	108-120	amyloid beta precursor protein	Homo sapiens	23-28
22220320-8	2004	Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes.	thioflavin T	108-120	amyloid beta precursor protein	Homo sapiens	23-28
22120172-2	2011	Here we analyze hIAPP aggregation in vitro, measured via thioflavin-T fluorescence.	thioflavin T	57-69	islet amyloid polypeptide	Homo sapiens	16-21
21885280-6	2011	Fluorescence staining of Tg APP/PS-1 mouse brain sections demonstrated high and specific labeling of Abeta plaques by 1 in the cortex region, which was confirmed with thioflavin-S staining of the same spots in the adjacent brain sections.	thioflavin T	167-179	presenilin 1	Mus musculus	32-36
21905118-7	2011	Despite this transient interaction, the various sHsps inhibited mature alpha-syn fibril formation as shown by a Thioflavin T assay and atomic force microscopy.	thioflavin T	112-124	synuclein alpha	Homo sapiens	71-80
21848289-6	2011	In the case of alpha-syn, the dominant effect of active hairpins was, besides a weakened ThT fluorescence response, the earlier appearance of insoluble aggregates that do not display amyloid characteristics with the few fibrils observed having abnormal morphology.	thioflavin T	89-92	synuclein alpha	Homo sapiens	15-24
21838267-9	2011	Abeta polymerization analysis-studied by thioflavin-T assay and electron microscopy-indicated that NL-1 stabilized Abeta aggregates in vitro.	thioflavin T	41-53	amyloid beta precursor protein	Homo sapiens	0-5
21410644-6	2011	The fibrillation of alpha-synuclein was monitored by Thioflavin T fluorescence and immunoblotting.	thioflavin T	53-65	synuclein alpha	Homo sapiens	20-35
21887833-5	2011	Fluorescence-activated cell-sorting analysis and Thioflavin-T binding assay demonstrated that the conjugated microspheres bind with high affinity and selectivity to Abeta, sequester it from the medium and reduce its aggregation.	thioflavin T	49-61	amyloid beta precursor protein	Rattus norvegicus	165-170
21812329-5	2011	A Thioflavin-T (Th-T) binding assay conducted after aging Abeta in vitro (37 degrees C, pH 7.4 in PBS) revealed that PIMT inhibited the increase of fluorescence caused by amyloid fibrillogenesis.	thioflavin T	2-14	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	117-121
21812329-5	2011	A Thioflavin-T (Th-T) binding assay conducted after aging Abeta in vitro (37 degrees C, pH 7.4 in PBS) revealed that PIMT inhibited the increase of fluorescence caused by amyloid fibrillogenesis.	thioflavin T	16-20	amyloid beta precursor protein	Homo sapiens	58-63
21812329-5	2011	A Thioflavin-T (Th-T) binding assay conducted after aging Abeta in vitro (37 degrees C, pH 7.4 in PBS) revealed that PIMT inhibited the increase of fluorescence caused by amyloid fibrillogenesis.	thioflavin T	16-20	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	117-121
21612934-5	2011	Circular dichroism spectroscopy, Western blot analysis, and thioflavin-T fluorescence intensity and cellular toxicity assays suggest that the self-assembly pathways of Abeta(E22Delta) differed from those of Abeta(WT).	thioflavin T	60-72	amyloid beta precursor protein	Homo sapiens	168-182
21545139-6	2011	PoxnoPC at a close to critical micelle concentration (~22.5 muM) causes a maximal increase in ThT fluorescence and the K(app) for fibril formation.	thioflavin T	94-97	latexin	Homo sapiens	60-63
21410644-11	2011	In contrast to the effect of dopamine on the aggregation of alpha-synuclein alone, in the presence of MPTP or MPP(+) , the aggregates formed are Thioflavin T-positive and amyloidogenic.	thioflavin T	145-157	synuclein alpha	Homo sapiens	60-75
21504025-5	2011	TTR protofibrils obtained by mild acidification appeared as flexible filaments with variable length and were able to bind amyloid markers (thioflavin T and Congo red).	thioflavin T	139-151	transthyretin	Homo sapiens	0-3
21300800-0	2011	Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T.	thioflavin T	110-122	transforming growth factor beta induced	Homo sapiens	34-49
21533606-4	2011	Vascular Abeta deposits in the brain of STZ-icv-treated rats (3 months old at the time of icv treatment) were visualized by Thioflavine-S staining, Congo red staining and Abeta immunohistochemistry.	thioflavin T	124-137	amyloid beta precursor protein	Rattus norvegicus	9-14
21388222-3	2011	We found that freshly polymerized beta2m fibrils at 0.1-0.3 mg/mL concentration completely dissociated to monomers upon 10 min incubation at 99  C. Fibril depolymerization was followed by thioflavin-T fluorescence and circular dichroism spectroscopy at various temperatures.	thioflavin T	188-200	beta-2-microglobulin	Homo sapiens	34-40
21451522-7	2011	These beneficial effects of ThT depend on the protein homeostasis network regulator heat shock factor 1 (HSF-1), the stress resistance and longevity transcription factor SKN-1, molecular chaperones, autophagy and proteosomal functions.	thioflavin T	28-31	heat shock transcription factor 1	Homo sapiens	84-103
21451522-7	2011	These beneficial effects of ThT depend on the protein homeostasis network regulator heat shock factor 1 (HSF-1), the stress resistance and longevity transcription factor SKN-1, molecular chaperones, autophagy and proteosomal functions.	thioflavin T	28-31	heat shock transcription factor 1	Homo sapiens	105-110
20805224-3	2010	Upon introduction of preformed seeds into cells overexpressing alpha-synuclein, abundant, highly filamentous alpha-synuclein-positive inclusions, which are extensively phosphorylated and ubiquitinated and partially thioflavin-positive, were formed within the cells.	thioflavin T	215-225	synuclein alpha	Homo sapiens	63-78
21327870-10	2011	On the other hand, the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5% sarkosyl, unlike TDP-43 when expressed in yeast cells.	thioflavin T	52-64	FUS RNA binding protein	Homo sapiens	44-47
20805224-3	2010	Upon introduction of preformed seeds into cells overexpressing alpha-synuclein, abundant, highly filamentous alpha-synuclein-positive inclusions, which are extensively phosphorylated and ubiquitinated and partially thioflavin-positive, were formed within the cells.	thioflavin T	215-225	synuclein alpha	Homo sapiens	109-124
20697279-12	2010	This study further validates ThT staining for detection of amyloid TGFBIp deposits.	thioflavin T	29-32	transforming growth factor beta induced	Homo sapiens	67-73
20888320-5	2010	Regarding other low-molecular compounds interacting with Abeta fibrils, thioflavin T (ThT) also enhanced the clearance of mutant Notch3.	thioflavin T	72-84	notch receptor 3	Homo sapiens	129-135
20888320-5	2010	Regarding other low-molecular compounds interacting with Abeta fibrils, thioflavin T (ThT) also enhanced the clearance of mutant Notch3.	thioflavin T	86-89	notch receptor 3	Homo sapiens	129-135
20888320-6	2010	These findings suggest that DAPH, SA, and ThT are potent reagents to dissociate the preformed aggregates of mutant Notch3 by disruption of intermolecular contacts of misfolded proteins.	thioflavin T	42-45	notch receptor 3	Homo sapiens	115-121
21048945-2	2010	It was shown that ThT fluorescence quantum yield varies from 0.0001 in water at room temperature to 0.28 in rigid isotropic solution (T/eta 0).	thioflavin T	18-21	endothelin receptor type A	Homo sapiens	136-139
20806406-3	2010	The results showed that the APP(Swe)/PS1(dE9) mice had significantly decreased hippocampal N-acetyl aspartate (NAA)/total creatine (tCr) level at 16 months of age, which was associated with degeneration of and intracellular deposition of thioflavine S-positive materials in hippocampal CA3 pyramidal neurons.	thioflavin T	238-249	presenilin 1	Mus musculus	37-40
20806406-3	2010	The results showed that the APP(Swe)/PS1(dE9) mice had significantly decreased hippocampal N-acetyl aspartate (NAA)/total creatine (tCr) level at 16 months of age, which was associated with degeneration of and intracellular deposition of thioflavine S-positive materials in hippocampal CA3 pyramidal neurons.	thioflavin T	238-249	anon-E9	Drosophila melanogaster	41-44
20806406-4	2010	The results of this study provide direct evidence showing association among Abeta pathology (intracellular deposition of thioflavine S-positive materials), neuronal degeneration, and metabolic changes observable with in vivo (1)H-MRS in the hippocampus of APP(Swe)/PS1(dE9) mice.	thioflavin T	121-132	amyloid beta (A4) precursor protein	Mus musculus	76-81
20721410-5	2010	A significant correlation with phospho-tau levels indicate that the in vitro test with magnetite nanoparticles and Thioflavin T dye on cerebrospinal fluid could be sensitive to changes mediated by early Alzheimer"s disease stages.	thioflavin T	115-127	microtubule associated protein tau	Homo sapiens	39-42
20801100-3	2010	Here, we have investigated the interaction of alpha-synuclein with ionic liquids by using several biochemical techniques including Thioflavin T assays and transmission electron microscopy (TEM).	thioflavin T	131-143	synuclein alpha	Homo sapiens	46-61
20509699-2	2010	Here we show that the beta(2) structural variant of poly(l-glutamic) acid forms fibrils with an amyloid-like morphology, ability to enhance fluorescence of thioflavin T, and seeding properties.	thioflavin T	156-168	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
20826442-6	2010	Here, we report the co-crystal structures of ThT with two alternative states of beta-2 microglobulin (beta2m); one monomeric, the other an amyloid-like oligomer.	thioflavin T	45-48	beta-2-microglobulin	Homo sapiens	80-100
20826442-6	2010	Here, we report the co-crystal structures of ThT with two alternative states of beta-2 microglobulin (beta2m); one monomeric, the other an amyloid-like oligomer.	thioflavin T	45-48	beta-2-microglobulin	Homo sapiens	102-108
20707388-7	2010	Fluorescence-detected thioflavin-T binding assays and transmission electron microscopy confirm that the compound inhibits unseeded amyloid fibril formation as well as disaggregates IAPP amyloid.	thioflavin T	22-34	islet amyloid polypeptide	Rattus norvegicus	181-185
20462500-6	2010	Mixing PLA2 with submicellar (22 microM) PoxnoPC caused a pronounced increase in Thioflavin T fluorescence, in keeping with the formation of amyloid-type fibers, which were seen also by electron microscopy.	thioflavin T	81-93	phospholipase A2 group IB	Homo sapiens	7-11
20640189-5	2010	Induced expression of TREM2 occurred co-incident with detection of thioflavine-S-positive amyloid deposits.	thioflavin T	67-78	triggering receptor expressed on myeloid cells 2	Mus musculus	22-27
20333453-5	2010	RESULTS: In both methods, insulin formed thioflavin T-binding species, most likely fibrils.	thioflavin T	41-53	insulin	Homo sapiens	26-33
20448140-3	2010	Here, we present evidence that the (mut)CDSN deposits display an affinity for amyloidophilic dyes, namely Congo red and thioflavin T.	thioflavin T	120-132	corneodesmosin	Homo sapiens	40-44
20400513-8	2010	Rather, neprilysin may act by reducing hIAPP fibrillogenesis, which we showed to be the case by fluorescence-based thioflavin T binding studies and electron microscopy.	thioflavin T	115-127	membrane metalloendopeptidase	Homo sapiens	8-18
20400513-8	2010	Rather, neprilysin may act by reducing hIAPP fibrillogenesis, which we showed to be the case by fluorescence-based thioflavin T binding studies and electron microscopy.	thioflavin T	115-127	islet amyloid polypeptide	Homo sapiens	39-44
20502498-5	2010	Thioflavine S staining was used to detect alpha-synuclein aggregation.	thioflavin T	0-13	synuclein alpha	Homo sapiens	42-57
20188180-5	2010	Experimentally, the conformational transitions in the early stages of the octapeptide Abeta(28-35) and its mutants A30G and A30I in solution were characterized by CD, Thioflavin assay and FRET spectroscopy.	thioflavin T	167-177	amyloid beta precursor protein	Homo sapiens	86-91
20160085-11	2010	Synthetic porcine IAPP was considerably less amyloidogenic than human IAPP as determined by transmission electron microscopy, circular dichroism, and thioflavin T binding.	thioflavin T	150-162	islet amyloid polypeptide	Homo sapiens	18-22
20172856-8	2010	In contrast, at low concentrations of SDS, PB1-F2 variants exhibited various abilities to form fibers that were evidenced as amyloid fibers in a thioflavin T assay.	thioflavin T	145-157	polybromo 1	Homo sapiens	43-46
20132485-4	2010	Cultured cells were readily induced to develop large, cytoplasmic alpha-syn filamentous aggregates that were hyperphosphorylated, often ubiquitinated and thioflavin positive.	thioflavin T	154-164	synuclein alpha	Homo sapiens	66-75
20017535-1	2010	The fibrillation process of the islet amyloid polypeptide (IAPP) and its fragment (IAPP(20-29)) was studied by means of Thioflavin T (ThT) fluorescence and transmission electron microscopy in the absence and presence of N-isopropylacrylamide:N-tert-butylacrylamide (NiPAM:BAM) copolymeric nanoparticles.	thioflavin T	134-137	islet amyloid polypeptide	Homo sapiens	59-63
20038605-7	2010	There was also evidence of amyloid formation in vivo: the surfaces of cells expressing wall-bound Als1p, Als5p, Muc1p, or Flo1p were birefringent and bound the fluorescent amyloid-reporting dye thioflavin T.	thioflavin T	194-206	Flo11p	Saccharomyces cerevisiae S288C	112-117
20111867-8	2010	Using the amyloid-specific dyes, Congo Red and Thioflavin S, we find that SOD1-positive inclusions in familial ALS, as well as TDP-43- and ubiquitin-positive inclusions in sporadic ALS, contain non-amyloid protein deposits.	thioflavin T	47-59	superoxide dismutase 1	Homo sapiens	74-78
20038605-7	2010	There was also evidence of amyloid formation in vivo: the surfaces of cells expressing wall-bound Als1p, Als5p, Muc1p, or Flo1p were birefringent and bound the fluorescent amyloid-reporting dye thioflavin T.	thioflavin T	194-206	flocculin FLO1	Saccharomyces cerevisiae S288C	122-127
19821579-5	2009	Our conjugates strongly inhibit amyloid fibril formation from Abeta(40) at low inhibitor to Abeta molar ratios (e.g., 0.02:1 in the case of the KLVFFA conjugate) at which Abeta-binding motifs alone are fully inactive (thioflavin T assays and atomic force microscopy observation).	thioflavin T	218-230	amyloid beta precursor protein	Homo sapiens	62-67
20133843-7	2010	Incubation of MetO-apoA-I for extended periods resulted in aggregation of the protein, and these aggregates bound Thioflavin T and Congo Red.	thioflavin T	114-126	apolipoprotein A1	Homo sapiens	19-25
19857478-7	2010	Correlation was also found between ThT fluorescence tertiles and LDL-cholesterol, total-cholesterol, and C-reactive protein.	thioflavin T	35-38	C-reactive protein	Homo sapiens	105-123
19857478-8	2010	Floatation fractionation of apoB containing lipoproteins showed that ThT reactivity in this fraction correlated with both serum oxidised-LDL and LDL-cholesterol levels.	thioflavin T	69-72	apolipoprotein B	Homo sapiens	28-32
20847447-5	2010	The fibrillogenic patterns of Abeta peptides in these compounds were analyzed by thioflavin T assay and SDS-PAGE with photoinduced cross-linking of unmodified proteins protocols, then were analyzed and compared to those obtained via transmission electron microscopy and neuronal cell viability assays.	thioflavin T	81-93	amyloid beta precursor protein	Homo sapiens	30-35
20173337-2	2010	When the repeat domain of human Tau (Tau(RD)) carrying the FTDP-17 mutation DeltaK280 is expressed, the cells develop aggregates, as seen by thioflavin S fluorescence, electron microscopy, and sarkosyl extraction methods.	thioflavin T	141-151	microtubule associated protein tau	Homo sapiens	32-35
20173337-2	2010	When the repeat domain of human Tau (Tau(RD)) carrying the FTDP-17 mutation DeltaK280 is expressed, the cells develop aggregates, as seen by thioflavin S fluorescence, electron microscopy, and sarkosyl extraction methods.	thioflavin T	141-151	microtubule associated protein tau	Homo sapiens	37-40
20173337-2	2010	When the repeat domain of human Tau (Tau(RD)) carrying the FTDP-17 mutation DeltaK280 is expressed, the cells develop aggregates, as seen by thioflavin S fluorescence, electron microscopy, and sarkosyl extraction methods.	thioflavin T	141-151	microtubule associated protein tau	Homo sapiens	59-66
19850675-2	2009	When Abeta solution is stirred with a magnetic stirrer bar at 37 degrees C, a rapid increase in thioflavin T fluorescence is observed.	thioflavin T	96-108	amyloid beta precursor protein	Homo sapiens	5-10
19720066-8	2009	In particular, ThT positive PrP aggregates produced from rec mouse PrP residues 89 to 230 lead to mostly oligomeric structures at low concentrations of guanidine hydrochloride, while more amyloidal structures were observed at higher concentrations of the denaturant.	thioflavin T	15-18	prion protein	Mus musculus	28-31
19720066-8	2009	In particular, ThT positive PrP aggregates produced from rec mouse PrP residues 89 to 230 lead to mostly oligomeric structures at low concentrations of guanidine hydrochloride, while more amyloidal structures were observed at higher concentrations of the denaturant.	thioflavin T	15-18	prion protein	Mus musculus	67-70
19810772-7	2009	Using thioflavin T fluorescence, electron microscopy, and electron paramagnetic resonance, we provide evidence that substoichiometric amounts of annexin A5 inhibit h-IAPP and alpha-synuclein misfolding and fibril formation.	thioflavin T	6-18	annexin A5	Homo sapiens	145-155
19916936-5	2009	Experiments with a mutant strain devoid of the BGL2 gene suggest the compensation of absent amyloid-like protein Bgl2p by increase in contents of thioflavin-binding proteins in the cell wall.	thioflavin T	146-156	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	47-51
19995549-5	2010	The tryptophan fluorescence of Abeta(1-40) F19W, but not Abeta(1-40) F4W, underwent a marked blue shift during fibril formation and this shift was temporally correlated with thioflavin T binding.	thioflavin T	174-186	amyloid beta precursor protein	Homo sapiens	31-36
20028124-5	2010	Thioflavin-T fluorescence-monitored kinetic experiments, transmission electron microscopy, and circular dichroism showed that rat IAPP lengthened the lag phase for amyloid formation by human IAPP, slowed the growth rate, reduced the amount of amyloid fibrils produced in a dose-dependent manner, and altered the morphology of the fibrils.	thioflavin T	0-12	islet amyloid polypeptide	Rattus norvegicus	130-134
20140223-11	2010	thioflavin T (ThT) fluorescence increased during alpha-Syn incubation regardless of ribosylation.	thioflavin T	0-12	synuclein alpha	Homo sapiens	49-58
20140223-11	2010	thioflavin T (ThT) fluorescence increased during alpha-Syn incubation regardless of ribosylation.	thioflavin T	14-17	synuclein alpha	Homo sapiens	49-58
19460190-9	2009	Thioflavin T-based fluorimetric assay revealed the ability of PMS1339 to inhibit AChE-induced Abeta aggregation.	thioflavin T	0-12	acetylcholinesterase	Mus musculus	81-85
19538143-2	2009	Insulin fibrils feature characteristics common to amyloid fibrils such as an elongated morphology, characteristic cross-beta diffraction pattern, Thioflavin T fluorescence, and Congo Red birefringence.	thioflavin T	146-158	insulin	Homo sapiens	0-7
19651786-7	2009	As shown by thioflavin T fluorescence monitoring, the formation of this cross-link accelerated the aggregation of native alpha-synuclein.	thioflavin T	12-24	synuclein alpha	Homo sapiens	121-136
21099274-5	2009	Using Thioflavin T fluorescence assay and transmission electron microscopy, we found that all dicyclic and tricyclic compounds in our screen were efficient inhibitors of insulin fibril formation.	thioflavin T	6-18	insulin	Homo sapiens	170-177
19690191-0	2009	Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.	thioflavin T	0-12	BAG cochaperone 1	Homo sapiens	40-67
19690191-0	2009	Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.	thioflavin T	0-12	BAG cochaperone 1	Homo sapiens	69-74
19550045-3	2009	Adopting UV spectroscopy, Congo red spectrophotometry and thioflavin T fluorimetry, we were able to quantify, in water, the very fast assembling time necessary for A beta (25-35) to form stable insoluble aggregates and their ability to seed or not seed fibril growth.	thioflavin T	58-70	amyloid beta precursor protein	Homo sapiens	164-170
19731227-2	2009	Amyloid fibrils composed of polymeric structures of the amyloid-beta (Abeta) concentrate at the center of senile plaques and accumulate in the walls of cerebral blood vessels, exhibiting extensive Congo red/thioflavin S staining.	thioflavin T	207-219	amyloid beta precursor protein	Homo sapiens	56-68
19580328-6	2009	The fibrillization of a truncated tau fragment that contains four MT-binding domains was monitored in an assay that employed complementary thioflavin T fluorescence and fluorescence polarization methods.	thioflavin T	139-151	microtubule associated protein tau	Homo sapiens	34-37
19675240-5	2009	Neuropathology includes mild scattered vacuolation and prominent, mainly cerebellar localized, thioflavin S-positive PrP plaques comprised of full-length PrP(A116V).	thioflavin T	95-107	prion protein	Homo sapiens	117-120
19675240-5	2009	Neuropathology includes mild scattered vacuolation and prominent, mainly cerebellar localized, thioflavin S-positive PrP plaques comprised of full-length PrP(A116V).	thioflavin T	95-107	prion protein	Homo sapiens	154-157
19594832-9	2009	Similar to amyloid oligomers, ELOA also interacts with thioflavin-T dye, shows a spherical morphology, assembles into ring-shaped structures, as monitored by atomic force microscopy, and exerts a toxic effect in cells.	thioflavin T	55-67	elongin A	Homo sapiens	30-34
19540126-9	2009	Of 16 diverse compounds selected for experimental screening, 2 prevented and reversed Abeta aggregation at 2-3microM concentration, as measured by Thioflavin T (ThT) fluorescence and ELISA assays.	thioflavin T	147-159	amyloid beta precursor protein	Homo sapiens	86-91
19540126-9	2009	Of 16 diverse compounds selected for experimental screening, 2 prevented and reversed Abeta aggregation at 2-3microM concentration, as measured by Thioflavin T (ThT) fluorescence and ELISA assays.	thioflavin T	161-164	amyloid beta precursor protein	Homo sapiens	86-91
19589380-7	2009	To reveal whether the VEGF-induced changes in soluble Abeta-level may be due to actions of VEGF on Abeta fibrillogenesis, the fibrillar status of Abeta was examined using the thioflavin-T binding assay.	thioflavin T	175-187	vascular endothelial growth factor A	Mus musculus	22-26
19266322-7	2009	Oxidative stress followed by proteasomal inhibition caused the occurrence of larger thioflavin S-positive inclusions, immunoreactive for tau and alphaB-crystallin, thus resembling glial cell inclusion bodies.	thioflavin T	84-96	crystallin, alpha B	Rattus norvegicus	145-162
19537801-2	2009	Thioflavin T fluorescence studies showed that submicellar levels of the short-chain phospholipids, dipentanoylphosphatidylcholine and dihexanoylphosphatidylcholine, strongly inhibited amyloid fibril formation by an 11-residue peptide derived from human apolipoprotein C-II (apoC-II(60-70)).	thioflavin T	0-12	apolipoprotein C2	Homo sapiens	253-272
19537801-2	2009	Thioflavin T fluorescence studies showed that submicellar levels of the short-chain phospholipids, dipentanoylphosphatidylcholine and dihexanoylphosphatidylcholine, strongly inhibited amyloid fibril formation by an 11-residue peptide derived from human apolipoprotein C-II (apoC-II(60-70)).	thioflavin T	0-12	apolipoprotein C2	Homo sapiens	274-281
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	242-254	serum amyloid A protein	Oncorhynchus mykiss	41-44
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	242-254	serum amyloid A protein	Oncorhynchus mykiss	130-133
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	242-254	serum amyloid A protein	Oncorhynchus mykiss	130-133
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	256-259	serum amyloid A protein	Oncorhynchus mykiss	41-44
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	256-259	serum amyloid A protein	Oncorhynchus mykiss	130-133
19268373-5	2009	Using an antiserum against a trout acute SAA peptide that was previously shown to specifically recognize intact recombinant trout SAA and peptides derived from it, we showed by confocal microscopy analysis extensive colocalization of SAA and thioflavin T (ThT) staining in the skeletal muscle fibers of infected fish, suggesting for the first time the presence of AA-derived aggregates in the skeletal muscle of a lower vertebrate.	thioflavin T	256-259	serum amyloid A protein	Oncorhynchus mykiss	130-133
19006330-0	2008	Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter.	thioflavin T	70-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
19250316-6	2009	hTTR and sbTTR formed thin, curved fibrils at low pH (pH 2-3) that bound thioflavin-T (thioflavin-T-positive) but did not stain with Congo Red (CR) (CR-negative).	thioflavin T	73-85	transthyretin	Homo sapiens	0-4
19250316-6	2009	hTTR and sbTTR formed thin, curved fibrils at low pH (pH 2-3) that bound thioflavin-T (thioflavin-T-positive) but did not stain with Congo Red (CR) (CR-negative).	thioflavin T	87-99	transthyretin	Homo sapiens	0-4
19384600-8	2009	However, N3, but not N4, was capable of partially antagonizing the binding of Thioflavin S to synthetic tau filaments.	thioflavin T	78-90	microtubule associated protein tau	Homo sapiens	104-107
19027885-6	2009	Importantly, cells accumulating alpha-Syn assemblies with different abilities to bind thioflavin S displayed different changes in phosphorylation and glycosylation.	thioflavin T	86-98	synuclein alpha	Homo sapiens	32-41
18813919-4	2009	This results in an unusually efficient, concentration-dependent conformational conversion of a large subfragment of PrP(94-233) into a soluble beta-structured oligomeric intermediate species, that readily forms a thioflavin-T-positive aggregate.	thioflavin T	213-225	prion protein	Mus musculus	116-119
19015863-5	2009	Similarly, plaque loads, both beta-amyloid (Abeta) and thioflavine S, in PS1 FAD and sporadic AD cases were not significantly different; however, in pathologically aged cases, they were significantly lower than those in PS1 cases, but were not different from sporadic AD cases.	thioflavin T	55-66	presenilin 1	Homo sapiens	73-76
19526145-1	2009	Fluorescence intensity of thioflavin T fluorogenic label increased significantly as a result of formation of enzyme-inhibitory complex with acetylcholinesterase of human blood erythrocytes.	thioflavin T	26-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-160
19526145-2	2009	Thioflavin T is a reversible inhibitor, selectively reacting with acetylcholinesterase.	thioflavin T	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
19526145-3	2009	Thioflavin T fluorescence intensity is proportional to acetylcholinesterase activity for the studied interval of enzyme activities.	thioflavin T	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-75
19007333-6	2009	FRET (fluorescence resonance energy transfer) between thioflavin-T and JC-1 was also employed to specifically identify the amyloid fibrils of alpha-synuclein.	thioflavin T	54-66	synuclein alpha	Homo sapiens	142-157
19010783-2	2009	At neutral pH, irradiation at 442 nm with a laser beam to excite ThT inhibited the fibril growth of beta(2)-microglobulin (beta2-m), a major component of amyloid fibrils deposited in patients with dialysis-related amyloidosis.	thioflavin T	65-68	beta-2-microglobulin	Homo sapiens	100-121
19094062-5	2009	Both WT synphilin-1 and R621C synphilin-1 led to the formation of Thioflavine-S positive inclusions in C57Bl/6 mice and degeneration of dopaminergic neurons in the substantia nigra.	thioflavin T	66-79	synuclein, alpha interacting protein (synphilin)	Mus musculus	8-13
19094062-5	2009	Both WT synphilin-1 and R621C synphilin-1 led to the formation of Thioflavine-S positive inclusions in C57Bl/6 mice and degeneration of dopaminergic neurons in the substantia nigra.	thioflavin T	66-79	synuclein, alpha interacting protein (synphilin)	Mus musculus	8-19
19325915-2	2009	Fibrillar inclusions containing SOD1 and SOD1 inclusions that bind the amyloid-specific dye thioflavin S have been found in neurons of transgenic mice expressing mutant SOD1.	thioflavin T	92-104	superoxide dismutase 1, soluble	Mus musculus	32-36
19325915-2	2009	Fibrillar inclusions containing SOD1 and SOD1 inclusions that bind the amyloid-specific dye thioflavin S have been found in neurons of transgenic mice expressing mutant SOD1.	thioflavin T	92-104	superoxide dismutase 1, soluble	Mus musculus	41-45
19325915-2	2009	Fibrillar inclusions containing SOD1 and SOD1 inclusions that bind the amyloid-specific dye thioflavin S have been found in neurons of transgenic mice expressing mutant SOD1.	thioflavin T	92-104	superoxide dismutase 1, soluble	Mus musculus	41-45
19325915-4	2009	When agitated at acidic pH in the presence of low concentrations of guanidine or acetonitrile, metalated SOD1 formed fibrillar material which bound both thioflavin T and Congo red and had circular dichroism and infrared spectra characteristic of amyloid.	thioflavin T	153-165	superoxide dismutase 1	Homo sapiens	105-109
18955112-4	2008	However, a thioflavin derivative, Pittsburgh Compound-B (PIB), which is a successful PET tracer for detecting Abeta plaques in AD brains, does not visualize Abeta plaques in APP and PS1/APP transgenic mice.	thioflavin T	11-21	amyloid beta (A4) precursor protein	Mus musculus	110-115
19006330-8	2008	The fluorescence of thioflavin T is strongly enhanced when it binds to the P-site of AChE, and this fluorescence is partially quenched when a second ligand binds to the A-site to form a ternary complex.	thioflavin T	20-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
18679819-7	2008	A differential pattern of thioflavine S staining was observed in the VCP treated group.	thioflavin T	26-37	valosin containing protein	Mus musculus	69-72
18767849-4	2008	To understand the role that this residual structure plays in the aggregation of this protein, we probed the mechanism of aggregation using protein engineering experiments and thus identified the regions of the sequence of HypF-N that play a critical role in the conversion of this dynamic state into thioflavin T-binding and beta-sheet containing protofibrils.	thioflavin T	300-312	fibroblast growth factor 23	Homo sapiens	222-226
18793854-2	2008	All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Abeta fibril formation.	thioflavin T	48-60	amyloid beta precursor protein	Homo sapiens	120-125
18793854-2	2008	All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Abeta fibril formation.	thioflavin T	62-65	amyloid beta precursor protein	Homo sapiens	120-125
27877974-1	2008	A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid beta peptide (1-42) (Abeta), as evaluated by thioflavin T assay and atomic force microscopy.	thioflavin T	151-163	amyloid beta precursor protein	Homo sapiens	127-132
18602908-0	2008	Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis.	thioflavin T	66-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
18602908-5	2008	Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group.	thioflavin T	151-163	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
18602908-6	2008	The fluorescence of thioflavin T is strongly enhanced when it binds to the P-site of AChE, and this fluorescence is partially quenched when a second ligand binds to the A-site to form a ternary complex.	thioflavin T	20-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
18590743-2	2008	We used noncovalent labeling with thioflavin T and 1-anilino-8-naphthalenesulfonate to follow the conformational changes occurring in beta-lactoglobulin during aggregation using time resolved luminescence.	thioflavin T	34-46	beta-lactoglobulin	Bos taurus	134-152
18753422-6	2008	To investigate their conformational change and amyloidogenicity, we measured circular dichroism spectra, the fluorescence intensity of tryptophan and thioflavin-T (ThT) of the recombinant beta(2)m.	thioflavin T	150-162	beta-2-microglobulin	Homo sapiens	188-196
18753422-6	2008	To investigate their conformational change and amyloidogenicity, we measured circular dichroism spectra, the fluorescence intensity of tryptophan and thioflavin-T (ThT) of the recombinant beta(2)m.	thioflavin T	164-167	beta-2-microglobulin	Homo sapiens	188-196
18753422-11	2008	EM showed that beta(2)m formed amorphous debris containing typical amyloid fibrils at 24 hours, when ThT fluorescence intensity was three-fold lower than that at six hours.	thioflavin T	101-104	beta-2-microglobulin	Homo sapiens	15-23
18682830-7	2008	A-Beta peptides (1-14) and (15-42) showed lower amyloidogenic potential than the full length counterpart, as assessed by thioflavin binding assay and ultrastructural analysis by transmission electron microscopy.	thioflavin T	121-131	amyloid beta precursor protein	Homo sapiens	0-6
18423506-0	2008	Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos.	thioflavin T	19-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
18423506-2	2008	The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme.	thioflavin T	83-95	acetylcholinesterase (Cartwright blood group)	Homo sapiens	223-243
18423506-3	2008	Incubation of 3 nM acetylcholinesterase active sites with 50 nM or 2000 nM inhibitor altered both the B(max) and K(d) for thioflavin t binding to the peripheral anionic site.	thioflavin T	122-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-39
18823586-7	2008	In addition, dityrosine crosslink formation was observed in acrolein-mediated NF-L aggregates and these aggregates displayed thioflavin T reactivity, reminiscent of amyloid.	thioflavin T	125-137	neurofilament light chain	Homo sapiens	78-82
18492724-5	2008	More importantly, cells expressing Zip-fused alpha-S, but not alpha-S alone, formed alpha-S immunopositive and thioflavin S-positive inclusions in 7 days.	thioflavin T	111-123	synuclein alpha	Homo sapiens	45-52
18474565-6	2008	These studies further revealed that high ThT fluorescence correlated with efficient diarrhoea induction, suggesting the importance of an optimal ThT-recognizable conformation in diarrhoea induction by purified NSP4.	thioflavin T	41-44	protease, serine 57	Mus musculus	210-214
18339749-3	2008	We showed that the interfacial activation of PLA(2), evident after the preceding lag phase, coincides with the formation of oligomers staining with thioflavin T and subsequently with Congo red.	thioflavin T	148-160	phospholipase A2 group IB	Homo sapiens	45-51
18474565-6	2008	These studies further revealed that high ThT fluorescence correlated with efficient diarrhoea induction, suggesting the importance of an optimal ThT-recognizable conformation in diarrhoea induction by purified NSP4.	thioflavin T	145-148	protease, serine 57	Mus musculus	210-214
18433772-3	2008	Current techniques for monitoring the kinetics of alpha-synuclein aggregation based on fluorescent dyes such as Thioflavin-T and Congo red detect only the terminal fibrillar species, are discontinuous and notoriously irreproducible.	thioflavin T	112-124	synuclein alpha	Homo sapiens	50-65
18353662-6	2008	We used in vitro assays such as thioflavin-T binding and aggregation inhibitors like Congo red to reveal that A beta-peptide in its A beta-globulomer conformation is a structural entity which is independent from amyloid fibril formation.	thioflavin T	32-44	amyloid beta precursor protein	Homo sapiens	110-116
17761424-4	2007	To determine the feasibility of distinguishing tau aggregates from beta-amyloid and alpha-synuclein aggregates with small molecule probes, a library containing 72,455 small molecules was screened for antagonists of tau-aggregate-mediated changes in Thioflavin S fluorescence, followed by secondary screens to distinguish the relative affinity for each substrate protein.	thioflavin T	249-259	microtubule associated protein tau	Homo sapiens	215-218
18167354-5	2008	Thioflavin T assay and electron microscopic study further supported the idea that TLS bound to tNhtt-42Q aggregates at the early stage of tNhtt-42Q amyloid formation.	thioflavin T	0-12	fused in sarcoma	Mus musculus	82-85
17980608-3	2008	Dialkylamino-substituted monomethine cyanine T-284 and meso-ethyl-substituted trimethine cyanine SH-516 demonstrated the higher emission intensity and selectivity to aggregated ASN than classic amyloid stain Thioflavin T, and could be proposed as novel efficient fluorescent probes for fibrillar ASN detection.	thioflavin T	208-220	synuclein alpha	Homo sapiens	177-180
17953662-0	2008	Congo red and thioflavin-T analogs detect Abeta oligomers.	thioflavin T	14-26	amyloid beta precursor protein	Homo sapiens	42-47
18314273-14	2008	However, cells bearing aggregated alpha-Syn, as revealed by proteinase K or Thioflavin-S treatment had significantly reduced Total-TH immunoreactivity, but high phosphoserine-TH labeling.	thioflavin T	76-88	synuclein alpha	Homo sapiens	34-43
18245081-4	2008	Using reduced and carboxymethylated kappa-casein (RCMkappa-CN), we show that fibril formation is accompanied by a characteristic increase in thioflavin T fluorescence intensity, solution turbidity, and beta-sheet content of the protein.	thioflavin T	141-153	casein kappa	Homo sapiens	36-48
19098439-4	2008	Circular dichroism analysis and fluorescence spectroscopy with thioflavin T indicate the presence of beta-sheet structures in Bgl2p isolates.	thioflavin T	63-75	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	126-131
18301778-10	2008	This pattern of degeneration coincides with the distribution of Thioflavin S-stained Abeta aggregates: Abeta42Arc formed large deposits in the cell body, Abeta42art accumulated preferentially in the neurites, while Abeta42 accumulated in both locations.	thioflavin T	64-76	beta amyloid protein precursor-like	Drosophila melanogaster	85-90
18202749-7	2008	PDAPP/Abca1 Tg mice developed a phenotype remarkably similar to that seen in PDAPP/Apoe(-/-) mice: there was significantly less amyloid beta-peptide (Abeta) deposition, a redistribution of Abeta to the hilus of the dentate gyrus in the hippocampus, and an almost complete absence of thioflavine S-positive amyloid plaques.	thioflavin T	283-294	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	6-11
17926318-0	2008	Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.	thioflavin T	0-10	amyloid beta precursor protein	Homo sapiens	38-50
17613523-8	2007	Additionally, continuous exposure of GAPDH-overexpressing HeLa cells to oxidants produced disulfide bonds in GAPDH leading to both detergent-insoluble and thioflavin-S-positive aggregates, which were associated with oxidative stress-induced cell death.	thioflavin T	155-167	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-42
20641418-15	2004	One promising approach of developing optical imaging probes is based on the development of small-molecules of Abeta-staining compounds, such as Congo red and thioflavin T.	thioflavin T	158-170	amyloid beta precursor protein	Homo sapiens	110-115
18057560-8	2007	We examined the effect of Congo red and Thioflavin T (potent fAbeta-binding compounds) on the binding of different proteases to fAbeta.	thioflavin T	40-52	FA complementation group A	Homo sapiens	61-67
18057560-8	2007	We examined the effect of Congo red and Thioflavin T (potent fAbeta-binding compounds) on the binding of different proteases to fAbeta.	thioflavin T	40-52	FA complementation group A	Homo sapiens	128-134
17679143-4	2007	With the use of Congo red staining, Thioflavin T fluorescence, electron microscopy, and a solid-phase binding assay on different synthetic peptides, we identified the last 18-19 amino acid residues to constitute the amyloid-promoting region of medin.	thioflavin T	36-48	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	244-249
18025470-4	2007	In addition, compared with APP(Sw,Ind) mice, double-transgenic (Ngb-Tg x APP(Sw,Ind)) mice showed reductions in thioflavin-S-stained extracellular Abeta deposits, decreased levels of Abeta(1-40) and Abeta(1-42), and improved behavioral performance in a Y-maze test of spontaneous alternations.	thioflavin T	112-124	neuroglobin	Mus musculus	64-67
17996039-3	2007	RESULTS: Here, we show that human latexin, a protein that shares the same fold with cystatin C, assembles into stable spherical amyloid-like oligomers that bind thioflavin-T and congo red similarly to common amyloid structures but do not evolve into fibrils.	thioflavin T	161-173	latexin	Homo sapiens	34-41
17939755-3	2007	Here we describe a simplified polyglutamine assay that uses a soluble, pathological-length polyglutamine construct (62 glutamines [Q62]) fused to glutathione-S-transferase (GST) and measure aggregate formation with fluorescence generated by thioflavin T binding.	thioflavin T	241-253	glutathione S-transferase kappa 1	Homo sapiens	173-176
17898208-4	2007	[11C]-Pittsburgh compound B ([11C]-PIB) is a thioflavin-T derivative that has allowed in vivo Abeta burden to be quantified using positron emission tomography (PET).	thioflavin T	45-57	amyloid beta precursor protein	Homo sapiens	94-99
17613523-8	2007	Additionally, continuous exposure of GAPDH-overexpressing HeLa cells to oxidants produced disulfide bonds in GAPDH leading to both detergent-insoluble and thioflavin-S-positive aggregates, which were associated with oxidative stress-induced cell death.	thioflavin T	155-167	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	109-114
17681791-5	2007	This binding had a capacity of about 0.1 moles of ThT bound per mole of insulin in fibril form.	thioflavin T	50-53	insulin	Homo sapiens	72-79
17597573-5	2007	Typical sigmoidal kinetics of the amyloidosis of alpha-synuclein assessed with the thioflavin-T binding fluorescence or the beta-sheet content was fully reproduced by the resveratrol binding fluorescence.	thioflavin T	83-95	synuclein alpha	Homo sapiens	49-64
17582434-4	2007	Abeta-(1-40) was incubated with equimolar GM1 at 37 degrees C. After a lag period of 6-12 h, amyloid fibrils were formed, as confirmed by circular dichroism, thioflavin-T fluorescence, size-exclusion chromatography, and transmission electron microscopy.	thioflavin T	158-170	amyloid beta precursor protein	Rattus norvegicus	0-5
17385016-2	2007	MATERIALS AND METHODS: Insulin aggregation on agitation was monitored spectrophotometrically and by fibrillation studies with a dye Thioflavin T.	thioflavin T	132-144	insulin	Homo sapiens	23-30
17482435-2	2007	The first part focused on the time-dependent structural changes of Abeta (1-40) by circular dichroism (CD) spectroscopy, thioflavin T (ThT) fluorescence assay, and atomic force microscopy (AFM).	thioflavin T	121-133	amyloid beta precursor protein	Homo sapiens	67-72
17482435-2	2007	The first part focused on the time-dependent structural changes of Abeta (1-40) by circular dichroism (CD) spectroscopy, thioflavin T (ThT) fluorescence assay, and atomic force microscopy (AFM).	thioflavin T	135-138	amyloid beta precursor protein	Homo sapiens	67-72
17662525-5	2007	When the brain sections of Tg2576 mice were treated with both tPA and plasminogen, levels of thioflavin-S fluorescence, congophilicity and birefringence in the compact amyloid plaques were significantly reduced, and the ultrastructure of Abeta42-fibrils was disrupted.	thioflavin T	93-105	plasminogen activator, tissue	Mus musculus	62-65
17518465-3	2007	Here we show that, upon vortexing, insulin forms two distinct types of fibrils with opposite local chiral preferences, which manifest in the opposite twists of bound dye, thioflavin T.	thioflavin T	171-183	insulin	Homo sapiens	35-42
17374542-3	2007	Immunohistochemical analysis of FBD and FDD brain lesions unveiled the presence of serum amyloid P-component (SAP) primarily associated with thioflavin positive amyloid deposits in spite of the significant pre-amyloid burden existing in both disorders.	thioflavin T	141-151	amyloid P component, serum	Homo sapiens	83-108
17374542-3	2007	Immunohistochemical analysis of FBD and FDD brain lesions unveiled the presence of serum amyloid P-component (SAP) primarily associated with thioflavin positive amyloid deposits in spite of the significant pre-amyloid burden existing in both disorders.	thioflavin T	141-151	amyloid P component, serum	Homo sapiens	110-113
17374526-7	2007	Purified IAPP forms fibrils as seen by Thioflavin-T fluorescence and AFM, and these fibrils were cytotoxic towards pancreatic cell line RIN5mf cells.	thioflavin T	39-51	islet amyloid polypeptide	Homo sapiens	9-13
17289401-4	2007	Acetylcholinesterase and gamma-cyclodextrin induced a characteristic ThT fluorescence similar to that with amyloid fibrils, whereas beta-cyclodextrin and the beta-sheet-rich transthyretin did not.	thioflavin T	69-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
17289401-5	2007	The cavities of acetylcholinesterase and gamma-cyclodextrin were of similar diameter and only these cavities could accommodate two ThT ions according to molecular modelling.	thioflavin T	131-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
17049613-0	2007	Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.	thioflavin T	47-59	amyloid beta precursor protein	Homo sapiens	23-28
17324933-6	2007	We found that Ydj1 was able to suppress formation of amyloid-like fibrils of Ure2 by delaying the process of fibril formation, as monitored by thioflavin T binding and atomic force microscopy imaging.	thioflavin T	143-155	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	14-18
17404210-5	2007	The results of a thioflavin T fluorescence assay to monitor Abeta aggregation disclosed that L-PGDS/beta-trace inhibited the spontaneous aggregation of Abeta (1-40) and Abeta (1-42) within its physiological range (1-5 microM) in CSF.	thioflavin T	17-29	prostaglandin D2 synthase	Homo sapiens	93-99
17536782-2	2007	A fast and sensitive analytical method for beta-amyloid (Abeta) aggregates was developed by the combination of CE-laser induced fluorescence and the fluorescence reagent, thioflavine T.	thioflavin T	171-184	amyloid beta precursor protein	Homo sapiens	57-62
17049613-1	2007	Thioflavin T (ThT) fluorescence is a commonly used method to monitor Abeta protein fibril formation.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	69-74
17049613-1	2007	Thioflavin T (ThT) fluorescence is a commonly used method to monitor Abeta protein fibril formation.	thioflavin T	14-17	amyloid beta precursor protein	Homo sapiens	69-74
17049613-8	2007	The newly developed ThT fluorescence protocol was used to quantify Abeta fibril content after treatment with CLN.	thioflavin T	20-23	amyloid beta precursor protein	Homo sapiens	67-72
17217959-6	2007	Synthetic apoC-II(56-76) readily formed fibrils, albeit with a different morphology and thioflavinT fluorescence yield compared to full-length apoC-II.	thioflavin T	88-99	apolipoprotein C2	Homo sapiens	10-17
17212777-6	2006	Seriously limited hydrolysis caused by higher peptide concentrations is consistent with monomeric/dimeric Abeta species participation in the process, confirmed by thioflavine T binding.	thioflavin T	163-176	amyloid beta precursor protein	Homo sapiens	106-111
17365997-4	2007	Co-incubation of cystatin C with monomeric Abeta1-42 significantly attenuated the in vitro formation of Abeta oligomers and protofibrils, as determined using electron microscopy (EM), dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, thioflavin T (ThT) spectrofluorimetry and gel chromatography.	thioflavin T	264-276	cystatin C	Homo sapiens	17-27
17365997-4	2007	Co-incubation of cystatin C with monomeric Abeta1-42 significantly attenuated the in vitro formation of Abeta oligomers and protofibrils, as determined using electron microscopy (EM), dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, thioflavin T (ThT) spectrofluorimetry and gel chromatography.	thioflavin T	264-276	amyloid beta precursor protein	Homo sapiens	43-48
17365997-4	2007	Co-incubation of cystatin C with monomeric Abeta1-42 significantly attenuated the in vitro formation of Abeta oligomers and protofibrils, as determined using electron microscopy (EM), dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, thioflavin T (ThT) spectrofluorimetry and gel chromatography.	thioflavin T	278-281	cystatin C	Homo sapiens	17-27
17365997-4	2007	Co-incubation of cystatin C with monomeric Abeta1-42 significantly attenuated the in vitro formation of Abeta oligomers and protofibrils, as determined using electron microscopy (EM), dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, thioflavin T (ThT) spectrofluorimetry and gel chromatography.	thioflavin T	278-281	amyloid beta precursor protein	Homo sapiens	43-48
16984903-7	2006	We show that mouse models (Mo/Hu APPswe PS1dE9 mice) homozygous for a destructive mutation of TLR4 (Tlr(Lps-d)/Tlr(Lps-d)) had increases in diffuse and fibrillar Abeta deposits by immunocytochemistry, fibrillar Abeta deposits by thioflavine-S staining and buffer-soluble and insoluble Abeta by ELISA in the cerebrum, as compared with TLR4 wild-type mouse models.	thioflavin T	229-242	toll-like receptor 4	Mus musculus	94-98
16973602-10	2006	Based on thioflavin T reactivity, the combination of Hsp70/40 and Hsp90 caused structural changes in oligomers but had little effect on fibrils.	thioflavin T	9-21	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
16973602-10	2006	Based on thioflavin T reactivity, the combination of Hsp70/40 and Hsp90 caused structural changes in oligomers but had little effect on fibrils.	thioflavin T	9-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	66-71
16981713-6	2006	Two scFvs with differing affinities for Abeta were studied, and both inhibited aggregation of Abeta42 as determined by thioflavin T binding assay and atomic force microscopy analysis and blocked Abeta-induced toxicity toward human neuroblastoma SH-SY5Y cells as determined by MTT and LDH release assays.	thioflavin T	119-131	amyloid beta precursor protein	Homo sapiens	40-45
16981713-6	2006	Two scFvs with differing affinities for Abeta were studied, and both inhibited aggregation of Abeta42 as determined by thioflavin T binding assay and atomic force microscopy analysis and blocked Abeta-induced toxicity toward human neuroblastoma SH-SY5Y cells as determined by MTT and LDH release assays.	thioflavin T	119-131	amyloid beta precursor protein	Homo sapiens	94-99
16981683-3	2006	First, seed-dependent fibril growth of beta2-microglobulin (beta2-m) and amyloid beta peptide was visualized in real time at the single fibril level using total internal reflection fluorescence microscopy combined with the binding of thioflavin T, an amyloid-specific fluorescence dye.	thioflavin T	234-246	beta-2-microglobulin	Homo sapiens	39-58
16953582-3	2006	By targeting the C-terminal beta-sheet region of an Abeta intermediate structure extracted from molecular dynamics simulations of Abeta conformational transition, a new inhibitor that abolishes Abeta fibrillation was discovered using virtual screening in conjunction with thioflavin T fluorescence assay and atomic force microscopy determination.	thioflavin T	272-284	amyloid beta precursor protein	Homo sapiens	52-57
16953582-3	2006	By targeting the C-terminal beta-sheet region of an Abeta intermediate structure extracted from molecular dynamics simulations of Abeta conformational transition, a new inhibitor that abolishes Abeta fibrillation was discovered using virtual screening in conjunction with thioflavin T fluorescence assay and atomic force microscopy determination.	thioflavin T	272-284	amyloid beta precursor protein	Homo sapiens	130-135
16982417-5	2006	Lentivirus-mediated expression of CatB in aged hAPP mice reduced preexisting amyloid deposits, even thioflavin S-positive plaques.	thioflavin T	100-112	cathepsin B	Mus musculus	34-38
16890957-2	2006	Here, we show at physiological salt concentrations and pH that native tetramers of apoE form soluble aggregates in vitro that bind the amyloid dyes thioflavin T and Congo red.	thioflavin T	148-160	apolipoprotein E	Homo sapiens	83-87
16914838-0	2006	Characteristics of the binding of thioflavin S to tau paired helical filaments.	thioflavin T	34-46	microtubule associated protein tau	Homo sapiens	50-53
16787929-4	2006	fAbeta was decreased in samples incubated with MMP-9 compared with other proteases, assessed using thioflavin-T.	thioflavin T	99-111	fumarylacetoacetate hydrolase	Mus musculus	0-6
16787929-4	2006	fAbeta was decreased in samples incubated with MMP-9 compared with other proteases, assessed using thioflavin-T.	thioflavin T	99-111	matrix metallopeptidase 9	Mus musculus	47-52
16787929-9	2006	MMP-9 digestion resulted in a decrease in thioflavin-S (ThS) staining.	thioflavin T	42-54	matrix metallopeptidase 9	Mus musculus	0-5
16787929-9	2006	MMP-9 digestion resulted in a decrease in thioflavin-S (ThS) staining.	thioflavin T	56-59	matrix metallopeptidase 9	Mus musculus	0-5
16787929-10	2006	Consistent with a role for endogenous MMP-9 in this process in vivo, MMP-9 immunoreactivity was detected in astrocytes surrounding amyloid plaques in the brains of aged APP/PS1 and APPsw mice, and increased MMP activity was selectively observed in compact ThS-positive plaques.	thioflavin T	256-259	matrix metallopeptidase 9	Mus musculus	69-74
16823041-5	2006	In addition, hARD1 forms protofilaments under physiological conditions of pH and temperature, as judged by electron microscopy and staining with the dyes Congo red and thioflavin T.	thioflavin T	168-180	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	13-18
16375913-9	2006	Ultimately, fibronectin fibrils appear to be partially structured like amyloid fibrils as shown by thioflavine T staining.	thioflavin T	99-112	fibronectin 1	Homo sapiens	12-23
16546210-7	2006	Light-scattering assays and bound thioflavin T fluorescence indicated that myosin aggregates when incubated at 43 degrees C for 30 min, while alphaB-crystallin suppressed this thermal aggregation.	thioflavin T	34-46	myosin, heavy chain 9, non-muscle	Gallus gallus	75-81
16914838-2	2006	Paired helical filaments (PHF) from Alzheimer"s disease (AD) patients, (whose main component is the microtubule associated protein, tau) bind to thioflavins.	thioflavin T	145-156	regulator of microtubule dynamics 1	Homo sapiens	100-130
16914838-2	2006	Paired helical filaments (PHF) from Alzheimer"s disease (AD) patients, (whose main component is the microtubule associated protein, tau) bind to thioflavins.	thioflavin T	145-156	microtubule associated protein tau	Homo sapiens	132-135
16914838-3	2006	By using a novel immunofluorescence method, the binding of ThS to isolated tau filaments was tested.	thioflavin T	59-62	microtubule associated protein tau	Homo sapiens	75-78
16914838-4	2006	Also, the characteristics of this binding of ThS to PHF or to the in vitro assembled tau filaments, have been analyzed.	thioflavin T	45-48	microtubule associated protein tau	Homo sapiens	85-88
16171385-8	2005	Interestingly, assembly of A beta(1-40) fibrils in the presence of a saturating concentration of the amyloid dye thioflavin T does not measurably affect fibril stability, in contrast to the commonly observed stabilization of globular proteins by ligand binding.	thioflavin T	113-125	amyloid beta precursor protein	Homo sapiens	27-33
16386398-3	2006	A long-term expression of TGF-beta1 results in persisting perivascular thioflavin-positive depositions, which did not disappear even though the transgene synthesis was repressed completely by administration of doxycycline.	thioflavin T	71-81	transforming growth factor, beta 1	Mus musculus	26-35
16386399-0	2006	Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus of APP/PS1 transgenic mice.	thioflavin T	0-11	presenilin 1	Mus musculus	96-99
16386399-2	2006	Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta).	thioflavin T	64-76	amyloid beta (A4) precursor protein	Mus musculus	137-142
16386399-2	2006	Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta).	thioflavin T	81-93	amyloid beta (A4) precursor protein	Mus musculus	137-142
16386399-7	2006	In the cortices of 7-14 months old APP/PS1 mice with age-dependent beta-amyloidosis, thioflavins selectively targeted fibrillar Abeta after biodegradation-induced release from their nanoparticulate carriers upon intracerebral injection.	thioflavin T	85-96	presenilin 1	Mus musculus	39-42
16386399-7	2006	In the cortices of 7-14 months old APP/PS1 mice with age-dependent beta-amyloidosis, thioflavins selectively targeted fibrillar Abeta after biodegradation-induced release from their nanoparticulate carriers upon intracerebral injection.	thioflavin T	85-96	amyloid beta (A4) precursor protein	Mus musculus	128-133
16198581-11	2006	Abeta fibril formation studies were performed by means of thioflavin T fluorescence assay.	thioflavin T	58-70	amyloid beta precursor protein	Homo sapiens	0-5
16893071-2	2006	Since C1q is colocalized with thioflavine-positive plaques and the C5b-9 complement membrane attack complex is detected in AD brain at autopsy, it is reasonable to hypothesize that complement activation has a role in the manifestation of AD either by its lytic capacity or as a trigger of glial infiltration and initiation of potentially damaging inflammation.	thioflavin T	30-41	complement C1q A chain	Homo sapiens	6-9
16331989-4	2005	Aggregation of IAPP is considerably faster at a lower pH (4.0 +/- 0.3) than at high pH (8.8 +/- 0.3), as judged by turbidity and thioflavine-T fluorescence studies.	thioflavin T	129-140	islet amyloid polypeptide	Homo sapiens	15-19
16554036-0	2006	Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge.	thioflavin T	13-25	ATP binding cassette subfamily B member 1	Homo sapiens	67-81
16554036-6	2006	Our results show that: (i) ThT is able to cross membranes and to penetrate inside the cells; (ii) ThT is a P-gp substrate; (iii) ThT is poor MRP1 substrate.	thioflavin T	27-30	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
16554036-6	2006	Our results show that: (i) ThT is able to cross membranes and to penetrate inside the cells; (ii) ThT is a P-gp substrate; (iii) ThT is poor MRP1 substrate.	thioflavin T	27-30	ATP binding cassette subfamily C member 1	Homo sapiens	141-145
16554036-6	2006	Our results show that: (i) ThT is able to cross membranes and to penetrate inside the cells; (ii) ThT is a P-gp substrate; (iii) ThT is poor MRP1 substrate.	thioflavin T	98-101	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
16554036-6	2006	Our results show that: (i) ThT is able to cross membranes and to penetrate inside the cells; (ii) ThT is a P-gp substrate; (iii) ThT is poor MRP1 substrate.	thioflavin T	98-101	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
16554036-7	2006	In conclusion, our results suggest that two factors could be involved in the low accumulation of ThT in the brain: ThT is a P-gp substrate and its lipophilicity is low.	thioflavin T	97-100	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
16554036-7	2006	In conclusion, our results suggest that two factors could be involved in the low accumulation of ThT in the brain: ThT is a P-gp substrate and its lipophilicity is low.	thioflavin T	115-118	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
16376376-5	2006	Alternatively, a novel, fast equilibrium pathway to distinct beta-sheet-rich oligomers with thioflavin T-binding capability is accessible to partially unfolded insulin monomers at pressures below approximately 200 bar in the absence of EtOH.	thioflavin T	92-104	insulin	Homo sapiens	160-167
16220550-7	2006	In addition, minocycline and to a lesser extent tetracycline inhibit fibril formation of Abeta as determined in a thioflavin-S-based fluorescence test.	thioflavin T	114-126	amyloid beta precursor protein	Homo sapiens	89-94
16207713-6	2005	We demonstrated that the targeted disruption of ABCA1 increases amyloid deposition in APP23 mice, and the effect is manifested by an increased level of Abeta immunoreactivity, as well as thioflavine S-positive plaques in brain parenchyma.	thioflavin T	187-198	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	48-53
16286092-4	2005	The mechanism of MIF amyloid formation was probed by electron microscopy, turbidity, Thioflavin T binding, circular dichroism spectroscopy, and analytical ultracentrifugation.	thioflavin T	85-97	macrophage migration inhibitory factor	Homo sapiens	17-20
16169977-1	2005	In 5% (v/v) trifluoroethanol, pH 5.5, 25 degrees C one of the acylphosphatases from Drosophila melanogaster (AcPDro2) forms fibrillar aggregates that bind thioflavin T and Congo red and have an extensive beta-sheet structure, as revealed by circular dichroism.	thioflavin T	155-167	Acylphosphatase 2	Drosophila melanogaster	109-116
16054644-3	2005	When incubated for several weeks at neutral pH in the presence of the denaturant guanidine hydrochloride, GroES formed a typical amyloid fibril; unbranched, twisted, and extended filaments stainable by thioflavin T and Congo red.	thioflavin T	202-214	chaperonin GroES	Escherichia coli	106-111
15615711-0	2005	Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer"s disease PET imaging agents on beta-amyloid peptide fibrils.	thioflavin T	66-78	amyloid beta precursor protein	Homo sapiens	130-150
15855161-2	2005	Each of the main compound classes, derived from thioflavin T (PIB), Congo Red (BSB), and aminonaphthalene (FDDNP) are believed to bind to mutually exclusive sites on the beta-amyloid (Abeta) peptide fibrils.	thioflavin T	48-60	amyloid beta precursor protein	Homo sapiens	184-189
15855161-3	2005	We recently reported the presence of three classes of binding sites (BS1, BS2, BS3) on the Abeta fibrils for thioflavin T derivatives and now extend these findings to demonstrate that these sites are also able to accommodate ligands from the other chemotype classes.	thioflavin T	109-121	amyloid beta precursor protein	Homo sapiens	91-96
15855161-6	2005	In contrast, each of the compounds examined were able to displace thioflavin T (BS1 probe) from the Abeta fibrils when evaluated in a fluorescence competition assay with Ki values for PIB, FDDNP, and BSB of 1865, 335, and 600 nM, respectively.	thioflavin T	66-78	amyloid beta precursor protein	Homo sapiens	100-105
15855161-8	2005	The results from these assays indicate that (i) the three classes of thioflavin T binding sites are able to accommodate a wide range of chemotype structures, (ii) BSB binds to two sites on the Abeta fibrils, one of which is BS2, and the other is distinct from the thioflavin T derivative binding sites, and (iii) there is no independent binding site on the fibrils for FDDNP, and the ligand binds to both the BS1 and BS3 sites with significantly lower affinities than previously reported.	thioflavin T	69-81	amyloid beta precursor protein	Homo sapiens	193-198
15707952-5	2005	The effector could also inhibit Abeta fibril formation, monitored by thioflavin T fluorescence intensity assay and transmitted electron microscopic images.	thioflavin T	69-81	amyloid beta precursor protein	Homo sapiens	32-37
15766269-5	2005	The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence.	thioflavin T	329-341	beta-2-microglobulin	Homo sapiens	62-70
15766269-5	2005	The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence.	thioflavin T	329-341	beta-2-microglobulin	Homo sapiens	82-90
15766269-5	2005	The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence.	thioflavin T	329-341	beta-2-microglobulin	Homo sapiens	82-90
16087241-6	2005	By way of contrast, beta-pleated conformers of NAC which were formed in the presence of Al(III) showed much lower levels of thioflavin T fluorescence and were poorer catalysts of the redox cycling of added Fe(II) and these properties were commensurate with an increased abundance of a novel amyloid morphology which consisted of twisted fibrils with a periodicity of about 100 nm.	thioflavin T	124-136	synuclein alpha	Homo sapiens	47-50
16098186-6	2005	PA700 inhibits both wild-type and A53T alpha-synuclein fibril formation as measured by Thioflavin T fluorescence.	thioflavin T	87-99	synuclein alpha	Rattus norvegicus	39-54
15837583-5	2005	Also, SAP and C1q enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays.	thioflavin T	95-107	amyloid P component, serum	Homo sapiens	6-9
15837583-5	2005	Also, SAP and C1q enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays.	thioflavin T	95-107	complement C1q A chain	Homo sapiens	14-17
15837583-5	2005	Also, SAP and C1q enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays.	thioflavin T	95-107	prion protein	Mus musculus	27-30
15215182-3	2004	In AD and DS cerebral cortex, CLAC invariably colocalized with Abeta42 but often lacked Abeta40- or thioflavin S (thioS)-reactivities.	thioflavin T	100-112	collagen type XXV alpha 1 chain	Homo sapiens	30-34
16076606-1	2005	Although the structures of Thioflavin T and another benzothiazole, BTA-1, are similar, they bind to A beta non-competitively, probably to different sites on the A beta(1-40) fibrils.	thioflavin T	27-39	amyloid beta precursor protein	Homo sapiens	100-106
15576361-2	2005	We showed that equine lysozyme assembles into soluble amyloid oligomers and protofilaments at pH 2.0 and 4.5, 57 degrees C. They bind thioflavin-T and Congo red similar to common amyloid structures, and their morphology was monitored by atomic force microscopy.	thioflavin T	134-146	lysozyme	Equus caballus	22-30
15590652-3	2005	Functionally, purified recombinant human p25alpha strongly stimulates the aggregation of alpha-synuclein in vitro as demonstrated by thioflavin-T fluorescence and quantitative electron microscopy.	thioflavin T	133-145	tubulin polymerization promoting protein	Homo sapiens	41-49
15590652-3	2005	Functionally, purified recombinant human p25alpha strongly stimulates the aggregation of alpha-synuclein in vitro as demonstrated by thioflavin-T fluorescence and quantitative electron microscopy.	thioflavin T	133-145	synuclein alpha	Homo sapiens	89-104
15628856-3	2005	A 22-residue peptide of beta(2)-microglobulin, Ser20-Lys41 (L-K3 peptide), obtained by digestion with Acromobacter protease I, formed amyloid-like fibrils in 50% (v/v) 2,2,2-trifluoroethanol and 10 mM HCl at 25 degrees C, as confirmed by thioflavin T fluorescence, circular dichroism spectra, and atomic force microscopy images.	thioflavin T	238-250	beta-2-microglobulin	Homo sapiens	24-45
15494420-9	2004	However, in the presence of GSK3 beta, Tau-D421, but not full-length tau, was present in the Sarkosyl-insoluble fraction and formed thioflavin-S-positive inclusions in the cell.	thioflavin T	132-144	glycogen synthase kinase 3 beta	Homo sapiens	28-37
15322100-9	2004	In contrast, however, ubiquitinated inclusions in alpha-synuclein-deficient neurons lacked amyloid-like fibrillization, as determined by thioflavine S staining.	thioflavin T	137-150	synuclein, alpha	Mus musculus	50-65
15505373-3	2004	In contrast, filamentous, thioflavine S-positive amyloid deposition in AbetaPP/PS mice was catalyzed at least 3000 fold by apoE.	thioflavin T	26-37	amyloid beta (A4) precursor protein	Mus musculus	71-78
15505373-3	2004	In contrast, filamentous, thioflavine S-positive amyloid deposition in AbetaPP/PS mice was catalyzed at least 3000 fold by apoE.	thioflavin T	26-37	apolipoprotein E	Mus musculus	123-127
15312232-6	2004	However, when ThT assays were repeated using Abeta1-42, modest, but statistically significant, profibrillogenic activity was detected in both apolipoprotein E epsilon3- and apolipoprotein E epsilon4-containing media and was similar in magnitude for the two isoforms.	thioflavin T	14-17	apolipoprotein E	Homo sapiens	142-189
15285804-15	2004	Identification of the thioflavin-S-positive material will facilitate the full appraisal of the clinical implication of the effects of anti-inflammatory drugs, and provide a more thorough understanding of TGF-beta1 actions in brain.	thioflavin T	22-34	transforming growth factor, beta 1	Mus musculus	204-213
15663196-5	2004	In this in vitro study, using transmission electron microscopy and thioflavin T binding assay, we show that mini-alphaA-crystallin arrests the fibril formation of Abeta peptides.	thioflavin T	67-79	amyloid beta precursor protein	Rattus norvegicus	163-168
15533443-3	2004	Here, seed-dependent amyloid fibril growth of Abeta(1-40) was visualized in real-time at the single fibril level using total internal reflection fluorescence microscopy (TIRFM) combined with the binding of thioflavin T, an amyloid-specific fluorescence dye.	thioflavin T	206-218	amyloid beta precursor protein	Homo sapiens	46-51
15466394-5	2004	At 10 months of age, an extensive neuronal loss (>50%) is present in the CA1/2 hippocampal pyramidal cell layer that correlates with strong accumulation of intraneuronal Abeta and thioflavine-S-positive intracellular material but not with extracellular Abeta deposits.	thioflavin T	180-191	carbonic anhydrase 12	Mus musculus	73-78
15215182-3	2004	In AD and DS cerebral cortex, CLAC invariably colocalized with Abeta42 but often lacked Abeta40- or thioflavin S (thioS)-reactivities.	thioflavin T	114-119	collagen type XXV alpha 1 chain	Homo sapiens	30-34
15215529-5	2004	Using a variety of spectroscopic methods we analyzed the nature of the structures formed after incubation at 37 degrees C. Electron microscopy showed that PI-9 forms ordered circular and elongated-type aggregates, which also bind the fluorescent dye Thioflavin T.	thioflavin T	250-262	serpin family B member 9	Homo sapiens	155-159
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	125-128	amyloid beta precursor protein	Homo sapiens	88-93
15033422-4	2004	After the exposure to ROS, alpha-synuclein aggregates were formed in the cytoplasm of these cells, and these were immunopositive for ubiquitin, nitrotyrosine and dityrosine, and positive for thioflavin S staining.	thioflavin T	191-203	synuclein alpha	Homo sapiens	27-42
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	111-123	immunglobulin heavy chain variable region	Homo sapiens	3-7
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	111-123	amyloid beta precursor protein	Homo sapiens	36-41
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	111-123	amyloid beta precursor protein	Homo sapiens	88-93
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	111-123	amyloid beta precursor protein	Homo sapiens	88-93
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	125-128	immunglobulin heavy chain variable region	Homo sapiens	3-7
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	125-128	amyloid beta precursor protein	Homo sapiens	36-41
15170333-6	2004	An scFv binding the 17-28 region of Abeta effectively inhibited in vitro aggregation of Abeta as determined by thioflavin T (ThT) fluorescence staining and atomic force microscopy (AFM) analysis, while an scFv binding the carboxyl-terminal region of Abeta (residues 29-40) did not inhibit aggregation.	thioflavin T	125-128	amyloid beta precursor protein	Homo sapiens	88-93
14985348-8	2004	The vascular Abeta accumulations were fibrillar, exhibiting strong thioflavin S staining, and occasionally presented signs of microhemorrhage.	thioflavin T	67-79	amyloid beta (A4) precursor protein	Mus musculus	13-18
14583196-5	2003	As seen with other amyloid proteins, the ABri fibrils had characteristic binding with Congo red and thioflavin-T, and the relative amounts of beta-sheet and amyloid fibril-like structures are influenced strongly by pH.	thioflavin T	100-112	integral membrane protein 2B	Homo sapiens	41-45
14769048-5	2004	Surface aggregation of tau protein was followed by the time-dependent appearance of a thioflavin S reactive intermediate that accumulated over a period of hours.	thioflavin T	86-96	microtubule associated protein tau	Homo sapiens	23-26
14592420-6	2003	In in vitro amyloid formation test measured with thioflavin T and electron microscopy, in the presence of VLDL/CM, amyloid formation of TTR was enhanced more than in the presence LDL or in the absence of lipoprotein species.	thioflavin T	49-61	transthyretin	Homo sapiens	136-139
14667496-6	2003	Thioflavin (or benzothiazole) derivatives displayed excellent in vitro characteristics with high binding affinities for Abeta aggregates (in subnanomolar to nanomolar range) and excellent plaque labeling of AD brain sections.	thioflavin T	0-10	amyloid beta precursor protein	Homo sapiens	120-125
12716908-2	2003	By using Thioflavin T, a dye that specifically binds to beta-sheet structures, we found that highly toxic forms of Abeta-aggregates were formed at the initial stage of fibrillogenesis, which is consistent with recent reports on Abeta oligomers.	thioflavin T	9-21	amyloid beta precursor protein	Homo sapiens	115-120
14523089-5	2003	Simultaneously, tau-positive aggregates that also stained with the amyloid-binding dye thioflavin-S as well as with antibodies to tau and alphaB-crystallin were detected.	thioflavin T	87-99	microtubule associated protein tau	Homo sapiens	16-19
14536032-6	2003	A thioflavin-T binding assay was performed to determine whether the copper/H2O2 system-induced in vitro aggregation of NF-L displays amyloid-like characteristics.	thioflavin T	2-14	neurofilament light chain	Homo sapiens	119-123
14536032-7	2003	The aggregate of NF-L displayed thioflavin T reactivity, which was reminiscent of amyloid.	thioflavin T	32-42	neurofilament light chain	Homo sapiens	17-21
12924949-3	2003	Circular dichroism and thioflavin T binding of a recombinant form of the C-terminal domain (rCBD) of thrombospondin-1 indicated a species highly enriched in beta-sheet secondary structure, with spectra similar to those of amyloid proteins.	thioflavin T	23-35	thrombospondin 1	Homo sapiens	101-117
12873148-3	2003	Mutagenesis combined with thioflavin T fluorescence detection, atomic force microscopic imaging, and cytotoxicity assays reveal that deletion of this sequence completely eliminates alpha-Syn fibrillization and cell toxicity.	thioflavin T	26-38	synuclein alpha	Homo sapiens	181-190
12716908-2	2003	By using Thioflavin T, a dye that specifically binds to beta-sheet structures, we found that highly toxic forms of Abeta-aggregates were formed at the initial stage of fibrillogenesis, which is consistent with recent reports on Abeta oligomers.	thioflavin T	9-21	amyloid beta precursor protein	Homo sapiens	228-233
12691846-2	2003	All tau-positive tangles were stained for thioflavine S, while approximately 84% of thioflavine S-stained tangles were tau-immunolabelled.	thioflavin T	84-97	microtubule associated protein tau	Homo sapiens	119-122
12691846-3	2003	Approximately 58-62% and 73-76% of thioflavine S- and tau-labelled tangles, respectively, were present within cortical neurons labelled for microtubule-associated protein-2.	thioflavin T	35-46	microtubule associated protein 2	Homo sapiens	140-172
12634062-2	2003	Circular dichroism, Fourier transform infrared spectroscopy and staining with Congo red and thioflavin T showed that p53tet-wt and p53tet-R337H adopt an alternative beta-sheet conformation (p53tet-wt-beta and p53tet-R337H-beta, respectively), characteristic of amyloid-like fibrils, when incubated at pH 4.0 and elevated temperatures.	thioflavin T	92-104	tumor protein p53	Homo sapiens	117-120
12697936-3	2003	A beta deposits were detected by immunostaining and thioflavin fluorescence, and quantified by using high-throughput digital image acquisition and analysis.	thioflavin T	52-62	amyloid beta (A4) precursor protein	Mus musculus	0-6
12668464-7	2003	The kinetics of aggregation (1 mg/mL apoC-II) as assessed using thioflavin T and preparative pelleting assays reveal that monomeric apoC-II is depleted after approximately 12 h incubation at room temperature.	thioflavin T	64-76	apolipoprotein C2	Homo sapiens	37-44
12668464-7	2003	The kinetics of aggregation (1 mg/mL apoC-II) as assessed using thioflavin T and preparative pelleting assays reveal that monomeric apoC-II is depleted after approximately 12 h incubation at room temperature.	thioflavin T	64-76	apolipoprotein C2	Homo sapiens	132-139
12962326-15	2003	Previous studies on amyloid proteins have suggested that such motifs promote fibril formation, and near-ultraviolet CD and thioflavin-T binding studies on RCM-kappa-casein support this concept.	thioflavin T	123-135	casein kappa	Bos taurus	159-171
12634062-2	2003	Circular dichroism, Fourier transform infrared spectroscopy and staining with Congo red and thioflavin T showed that p53tet-wt and p53tet-R337H adopt an alternative beta-sheet conformation (p53tet-wt-beta and p53tet-R337H-beta, respectively), characteristic of amyloid-like fibrils, when incubated at pH 4.0 and elevated temperatures.	thioflavin T	92-104	tumor protein p53	Homo sapiens	131-134
11958955-8	2002	The Cu,Zn-SOD/H(2)O(2)-induced alpha-synuclein aggregates displayed strong thioflavin-S reactivity, reminiscent of amyloid.	thioflavin T	75-85	superoxide dismutase 1	Homo sapiens	10-13
12573540-3	2003	Cholesterol and apolipoprotein E co-localized to the core of thioflavin S-positive (fibrillar) plaques, but not thioflavin S-negative (diffuse) plaques from an early age.	thioflavin T	61-73	apolipoprotein E	Mus musculus	16-32
12397073-8	2002	6-Hydroxydopamine triggers thioflavin T-positive deposits in alpha-synuclein, but not mock-transfected TSM1 neurons, and drastically increases alpha-synuclein immunoreactivity.	thioflavin T	27-39	synuclein, alpha	Mus musculus	61-76
12603271-7	2003	Synthetic Abeta was used to produce three different samples (Abeta-fibrilar; Abeta-aggregated; Abeta-AGE), which were characterized for beta-sheeted fibrils by the thioflavin-T test and electron microscopy.	thioflavin T	164-176	amyloid beta (A4) precursor protein	Mus musculus	10-15
12435752-2	2003	Circular dichroism and fluorometric thioflavin T kinetic studies showed a transition of alpha-synuclein from unaggregated to highly aggregated states, characterized by lag and transition phases.	thioflavin T	36-48	synuclein alpha	Homo sapiens	88-103
12460583-4	2002	In this study, we characterize the kinetics and conformational changes of alpha(1)-antitrypsin polymerization at pH 4 using tryptophan fluorescence, circular dichroism, turbidity changes and thioflavin T binding.	thioflavin T	191-203	serpin family A member 1	Homo sapiens	74-94
12480736-4	2002	Transgenic mice overexpressing TGF-beta1 in astrocytes develop AD-like cerebrovascular abnormalities, including perivascular astrocytosis, microvascular basement membrane thickening, and accumulation of thioflavin S-positive amyloid in the absence of parenchymal degeneration.	thioflavin T	203-215	transforming growth factor, beta 1	Mus musculus	31-40
12217698-6	2002	In contrast, incubating alpha-synuclein at low pH (pH 4.0 or pH 5.0) resulted in the rapid formation of turbid suspensions characterized by strong ANS binding, reduced thioflavin-T binding and reduced seeding efficiency.	thioflavin T	168-180	synuclein alpha	Homo sapiens	24-39
12135814-7	2002	Although rat TTR in buffer of pH 7.0 could not make amyloid fibrils, rat TTR at pH 2.0-3.5 significantly formed amyloid fibrils, as confirmed by the thioflavin T test and electron microscopy.	thioflavin T	149-161	transthyretin	Rattus norvegicus	73-76
12453634-4	2002	Thioflavin-S staining of alpha-synuclein aggregates showed that they displayed characteristic fibrillar structures.	thioflavin T	0-12	synuclein alpha	Homo sapiens	25-40
11958955-8	2002	The Cu,Zn-SOD/H(2)O(2)-induced alpha-synuclein aggregates displayed strong thioflavin-S reactivity, reminiscent of amyloid.	thioflavin T	75-85	synuclein alpha	Homo sapiens	31-46
11707429-8	2002	Thioflavine S-positive structures accumulated within neurons of the substantia nigra pars compacta, and dual labeling and confocal imaging confirmed that these aggregates contained alpha-synuclein.	thioflavin T	0-13	synuclein, alpha	Mus musculus	181-196
11601499-6	2001	Mice expressing ApoE4 in combination with APPsw have accelerated A beta deposition in the brain as assessed by enzyme immunoassay for A beta40 and A beta42 extractable in 70% formic acid, by assessment of amyloid plaque formation using thioflavin-S staining, and by immunohistochemical staining with antibodies specific for A beta40 or A beta42 and the 4G8 monoclonal or 162 polyclonal antibody.	thioflavin T	236-248	apolipoprotein E	Homo sapiens	16-21
11846043-3	2002	These Abeta-deposits can be visualized by thioflavin S, Congo red staining, silver staining methods and immunohistochemistry.	thioflavin T	42-54	amyloid beta precursor protein	Homo sapiens	6-11
12235811-3	2001	Congo-red birefringency and thioflavin-S reactivity in NFT-bearing neurons also demonstrated that the tau aggregation forms a beta-sheet structure.	thioflavin T	28-38	microtubule associated protein tau	Homo sapiens	102-105
11588612-3	2001	We have used RP-HPLC and thioflavin T fluorescence to demonstrate that Abeta42 is rapidly cleaved by the protease plasmin and that cleavage prevented the aggregation of Abeta42, and its cleavage products, into beta-pleated sheet structures.	thioflavin T	25-37	plasminogen	Homo sapiens	114-121
11300721-3	2001	C1q was consistently associated with thioflavine-S positive Abeta plaques in DS brain and increased with more extensive age-dependent Abeta deposition.	thioflavin T	37-50	complement C1q A chain	Homo sapiens	0-3
11553297-6	2001	Quantification of thioflavine-S-positive Abeta deposits revealed a marked acceleration of amyloid deposition in LPS-treated APPV717F+/+-apoE+/+ mice compared to nontreated or vehicle-treated APPV717F+/+-apoE+/+ mice (P = 0.005).	thioflavin T	18-31	apolipoprotein E	Mus musculus	136-140
11553297-6	2001	Quantification of thioflavine-S-positive Abeta deposits revealed a marked acceleration of amyloid deposition in LPS-treated APPV717F+/+-apoE+/+ mice compared to nontreated or vehicle-treated APPV717F+/+-apoE+/+ mice (P = 0.005).	thioflavin T	18-31	apolipoprotein E	Mus musculus	203-207
11437366-4	2001	Tau polymerization, under physiological tau concentrations in the presence of dithiothreitol (DTT), was followed by a Thioflavine S fluorescence assay.	thioflavin T	118-129	microtubule associated protein tau	Homo sapiens	0-3
11313335-0	2001	Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.	thioflavin T	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
11313335-5	2001	Here we report that thioflavin T, a fluorophore widely used to detect amyloid structure in proteins, binds selectively to the AChE peripheral site with an equilibrium dissociation constant of 1.0 microm.	thioflavin T	20-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
11313335-6	2001	The fluorescence of the bound thioflavin T is increased more than 1000-fold over that of unbound thioflavin T, the greatest enhancement of fluorescence for the binding of a fluorophore to AChE yet observed.	thioflavin T	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-192
11313335-6	2001	The fluorescence of the bound thioflavin T is increased more than 1000-fold over that of unbound thioflavin T, the greatest enhancement of fluorescence for the binding of a fluorophore to AChE yet observed.	thioflavin T	97-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-192
11313335-8	2001	The observation of this partial quenching of thioflavin T fluorescence is a major advance in the study of AChE for two reasons.	thioflavin T	45-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
11313335-10	2001	Second, it indicates that ligand binding to the acylation site initiates a change in the local AChE conformation at the peripheral site that quenches the fluorescence of bound thioflavin T.	thioflavin T	176-188	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
11376898-5	2001	Thioflavin T fluorometric assay and electron microscopy revealed that entactin significantly inhibited Abeta1-40 (Abeta40) fibril formation at an Abeta40:entactin molar ratio of 50:1.	thioflavin T	0-12	nidogen 1	Homo sapiens	70-78
11413227-5	2001	Both a thioflavine-T (Th-T) fluorometric assay and circular dichroism (CD) spectroscopy showed the amyloid fibril formation of Abeta in PBS to be much higher than that of Abeta in PB.	thioflavin T	7-20	amyloid beta precursor protein	Homo sapiens	127-132
11413227-5	2001	Both a thioflavine-T (Th-T) fluorometric assay and circular dichroism (CD) spectroscopy showed the amyloid fibril formation of Abeta in PBS to be much higher than that of Abeta in PB.	thioflavin T	22-26	amyloid beta precursor protein	Homo sapiens	127-132
11374584-4	2001	We have used thioflavin T fluorescence and reverse phase high performance liquid chromatography to show that ATP, and in particular AlATP, promoted the formation of thioflavin T-reactive fibrils of beta amyloid and, an unrelated amyloidogenic peptide, amylin.	thioflavin T	165-177	islet amyloid polypeptide	Homo sapiens	252-258
11306576-9	2001	Additionally, the soluble aggregates formed by the amyloidogenic TTR variants showed morphological and thioflavin-T fluorescence properties characteristic of amyloid.	thioflavin T	103-115	transthyretin	Homo sapiens	65-68
11437372-4	2001	The method detects Abeta aggregation in its earliest stages, well before complexation becomes apparent in more conventional methods such as the thioflavin T fluorescence assay.	thioflavin T	144-156	amyloid beta precursor protein	Homo sapiens	19-24
11300721-3	2001	C1q was consistently associated with thioflavine-S positive Abeta plaques in DS brain and increased with more extensive age-dependent Abeta deposition.	thioflavin T	37-50	amyloid beta precursor protein	Homo sapiens	60-65
11300721-4	2001	In contrast, little or no C1q labeling was associated with diffuse or thioflavine-S negative Abeta deposits.	thioflavin T	70-81	complement C1q A chain	Homo sapiens	26-29
11004584-1	2000	Among various dyes including congo red, thioflavin S, thioflavin T, eosin, rhodamine 6G, and phenol red, the eosin was the only dye that induced self-oligomerization of alpha-synuclein in the presence of a chemical coupling reagent of N-(ethoxycarbonyl)-2-ethoxy-1, 2-dihydroquinoline.	thioflavin T	54-66	synuclein alpha	Homo sapiens	169-184
11045665-3	2000	Elimination of APOE resulted in a redistribution and alteration in the character of Abeta deposition in homozygous APP(V717F) tg mice, with a dramatic reduction in cortical and dentate gyrus deposition, prominent increase in diffuse CA1 and CA3 deposition, and prevention of the formation of thioflavin-S-positive deposits.	thioflavin T	292-304	apolipoprotein E	Mus musculus	15-19
11045665-3	2000	Elimination of APOE resulted in a redistribution and alteration in the character of Abeta deposition in homozygous APP(V717F) tg mice, with a dramatic reduction in cortical and dentate gyrus deposition, prominent increase in diffuse CA1 and CA3 deposition, and prevention of the formation of thioflavin-S-positive deposits.	thioflavin T	292-304	amyloid beta (A4) precursor protein	Mus musculus	84-89
10869348-9	2000	Remarkably the overloading of Tau on microtubules leads to a thioflavin S fluorescence increase reminiscent of that seen with Tau aggregated into Alzheimer paired helical filaments.	thioflavin T	61-71	microtubule associated protein tau	Homo sapiens	30-33
10913285-2	2000	Using Congo red and thioflavin-T binding, electron microscopy, and X-ray fiber diffraction, we have determined conditions under which recombinant monomeric beta(2)m spontaneously associates to form fibrils in vitro.	thioflavin T	20-32	beta-2-microglobulin	Homo sapiens	156-164
10690926-7	2000	Thioflavin S and Congo red staining indicated a beta-pleated sheet conformation of the A beta deposits, implying formation of fibrils.	thioflavin T	0-12	amyloid beta precursor protein	Rattus norvegicus	87-93
10889036-1	2000	Human apolipoprotein C-II (apoC-II) self-associates in solution to form aggregates with the characteristics of amyloid including red-green birefringence in the presence of Congo Red under cross-polarized light, increased fluorescence in the presence of thioflavin T, and a fibrous structure when examined by electron microscopy.	thioflavin T	253-265	apolipoprotein C2	Homo sapiens	6-25
10889036-1	2000	Human apolipoprotein C-II (apoC-II) self-associates in solution to form aggregates with the characteristics of amyloid including red-green birefringence in the presence of Congo Red under cross-polarized light, increased fluorescence in the presence of thioflavin T, and a fibrous structure when examined by electron microscopy.	thioflavin T	253-265	apolipoprotein C2	Homo sapiens	27-34
10940227-3	2000	We describe in detail the morphological development of the Abeta polymerization process from pseudo-spherical structures and protofibrils to mature thioflavin-T-positive/Congo red-positive amyloid fibrils.	thioflavin T	148-160	amyloid beta precursor protein	Homo sapiens	59-64
10952022-10	2000	CONCLUSIONS: ApoE was immunocytochemically detected in neuritic plaques that were positive for thioflavine-S.	thioflavin T	95-106	apolipoprotein E	Mus musculus	13-17
10686395-6	2000	Using thioflavin T assay, we find that heparin promotes fibrillogenesis of amyloid beta-peptide whereas apoE abolishes this effect.	thioflavin T	6-18	apolipoprotein E	Homo sapiens	104-108
11261806-5	2000	AChE infusion into rat hippocampus determines the appearance of anti-Abeta and thioflavine-S positive plaques, and AChE-Abeta toxicity on hippocampal cultures was blocked by lithium, an activator of the Wnt cascade.	thioflavin T	79-90	acetylcholinesterase	Rattus norvegicus	0-4
10611946-8	1999	During the incubation of fA beta 2M with native beta 2-m at 37 degrees C, the fluorescence of thioflavin T increased without a lag phase and proceeded to equilibrium.	thioflavin T	94-106	beta-2-microglobulin	Homo sapiens	28-35
10611368-5	1999	ApoE immunoreactivity was detected in a subset of Abeta immunoreactive deposits and in virtually all thioflavine-S-fluorescent amyloid deposits.	thioflavin T	101-112	apolipoprotein E	Mus musculus	0-4
10674423-3	1999	Interleukin-1beta- and tumor necrosis factor alpha-immunopositive microglia were localized with thioflavine-positive (fibrillar) Abeta deposits.	thioflavin T	96-107	interleukin 1 beta	Mus musculus	0-17
10569934-1	1999	We analyzed the interaction of two kinds of amyloid beta-peptides (A beta), i.e., A beta(1-42) and A beta(1-40), in the kinetics of beta-amyloid fibril (fA beta) formation in vitro, based on a nucleation-dependent polymerization model using fluorescence spectroscopy with thioflavin T.	thioflavin T	272-284	amyloid beta precursor protein	Homo sapiens	67-73
10674423-3	1999	Interleukin-1beta- and tumor necrosis factor alpha-immunopositive microglia were localized with thioflavine-positive (fibrillar) Abeta deposits.	thioflavin T	96-107	tumor necrosis factor	Mus musculus	23-50
9675319-3	1998	Since some Lewy bodies in Parkinson"s disease display Thioflavine-S reactivity, our results may suggest that amyloidogenic properties of NACP/alpha-synuclein may play a crucial role in pathogenesis of disorders with Lewy bodies such as Parkinson"s disease.	thioflavin T	54-65	synuclein alpha	Homo sapiens	137-141
9751195-3	1998	Expression of wild-type A beta in these animals leads to rapid production of amyloid deposits reactive with Congo red and thioflavin S.	thioflavin T	122-134	amyloid beta precursor protein	Homo sapiens	24-30
10521263-7	1999	The L55P-TTR protofilaments formed in vitro bind Congo red and thioflavin T (albeit more weakly than the fibrils produced at acidic pH), suggesting that the structure observed probably represents an amyloid precursor.	thioflavin T	63-75	transthyretin	Homo sapiens	9-12
10514414-6	1999	Fluorometry using thioflavine T also revealed that AApoAII fibril extension was inhibited by the addition of type B apoA-II in vitro.	thioflavin T	18-31	apolipoprotein A-II	Mus musculus	116-123
10208537-6	1999	NACP/ alpha-synuclein aggregates displayed strong thioflavine-S and congo-red reactivity, reminiscent of amyloid.	thioflavin T	50-61	synuclein alpha	Homo sapiens	0-4
10208537-6	1999	NACP/ alpha-synuclein aggregates displayed strong thioflavine-S and congo-red reactivity, reminiscent of amyloid.	thioflavin T	50-61	synuclein alpha	Homo sapiens	6-21
9568695-6	1998	Using thioflavin T fluorometry, Congo red staining, and electron microscopy methodology, intact perlecan was found to enhance amylin fibril formation in a dosage-dependent manner, with the majority of these effects attributed to the heparan sulfate GAG chains of perlecan.	thioflavin T	6-18	heparan sulfate proteoglycan 2	Rattus norvegicus	96-104
9714466-2	1998	A thioflavine-T fluorometric assay showed a synthetic peptide containing the YFQRYLI sequence from the laminin alpha1 chain to inhibit Abeta40 fibril formation while the inhibitory effect of this peptide was found to be somewhat less than that of intact laminin 1.	thioflavin T	2-13	laminin subunit alpha 1	Rattus norvegicus	103-117
9690671-3	1998	However, A beta deposits in the presubiculum are thioflavin-S- and Congo red-negative--and thus, nonfibrillar--even after 11 to 19 years of AD.	thioflavin T	49-61	amyloid beta precursor protein	Homo sapiens	9-15
9546999-5	1998	In 5 aged primates, the cortex surrounding the amyloid beta lesions contained argyrophilic, thioflavine S fluorescent, Alz 50 and ubiquitin immunoreactive neurons and perikarya.	thioflavin T	92-105	amyloid beta precursor protein	Homo sapiens	47-59
9514645-2	1998	Using thioflavine T fluorescence and turbidity assays we demonstrated that the rate of aggregation for the Z AAT in the presence of LA at a molar ratio of 1:5 AAT to LA, in Tris-buffered saline, pH 7.4, is at least twice that of the Z protein alone or the M variant with and without LA.	thioflavin T	6-17	serpin family A member 1	Homo sapiens	109-112
9351682-4	1997	It is demonstrated herein that the assembly of A beta(25-35) into thioflavin T-reactive fibrils and their subsequent rearrangement into advanced glycation endproducts is accelerated by ATP.	thioflavin T	66-78	amyloid beta precursor protein	Homo sapiens	47-53
9403484-7	1997	The BChE-positive plaques were found only in areas containing thioflavine S-positive compact plaques, both neuritic and nonneuritic.	thioflavin T	62-73	butyrylcholinesterase	Homo sapiens	4-8
9403484-8	1997	Within such areas, almost all (>98%) BChE-containing plaques bound thioflavine S, and almost all (93%) thioflavine S plaques contained BChE.	thioflavin T	67-78	butyrylcholinesterase	Homo sapiens	37-41
9475506-6	1998	Considering that the total amount of amyloid formed, measured by thioflavine-T fluorescence, was similar for both AChE preparations, our results suggest that the edrophonium-AChE possesses an higher intrinsic capacity to stimulate the aggregation of Abeta(1-40) peptide.	thioflavin T	65-76	acetylcholinesterase	Bos taurus	174-178
9325095-9	1997	AChE was seen to form strong complexes with the Abeta(12-28) fibrils as such complexes stained positively for both thioflavine-T and AChE activity, were resistant to high ionic strength treatment, and were partially sensitive to detergents, suggesting that hydrophobic interactions may play a role in the stabilization of the AChE-Abeta complex.	thioflavin T	115-126	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
9245692-3	1997	Quantitative radioassay (radioactivity of soluble IAPP after adding 125I-IAPP) and thioflavine fluorescence spectroscopy showed that insulin, C-peptide, and pancreastatin inhibited fibril formation by 60-100% at ratio 100:1 (peptide:IAPP), whereas at 1:10 or 1:100, i.e., IAPP in excess, a potentiated IAPP fibril formation was induced by the peptides.	thioflavin T	83-94	insulin	Homo sapiens	133-140
9202333-3	1997	In this report, we show that the fibrillar aggregation state of A beta, as determined by thioflavin T fluorometry, electron microscopy, and staining with Congo red and thioflavine S, is precisely correlated with the ability of the peptide to induce the formation of activated fragments of the complement proteins C4 and C3.	thioflavin T	89-101	amyloid beta precursor protein	Homo sapiens	64-70
9202333-3	1997	In this report, we show that the fibrillar aggregation state of A beta, as determined by thioflavin T fluorometry, electron microscopy, and staining with Congo red and thioflavine S, is precisely correlated with the ability of the peptide to induce the formation of activated fragments of the complement proteins C4 and C3.	thioflavin T	168-181	amyloid beta precursor protein	Homo sapiens	64-70
9186492-4	1997	Mixing of preformed beta (1-40) amyloid fibrils with ThT in a stopped-flow spectrophotometer, monitoring fluorescence emission at > 475 nm while exciting at 450 nm, distinguished multiple kinetic phases of roughly equivalent amplitude with tau"s in the ranges of 0.007, 0.05, 0.75, and 10-20 s. The fastest reaction appears to reflect a bimolecular dye binding event while the remaining reactions are rate-limited by protein tertiary or quaternary conformational changes.	thioflavin T	53-56	microtubule associated protein tau	Homo sapiens	240-243
9232632-3	1997	The amount of cross beta-pleated sheet structure of A beta 1-40 fibrils was found to decrease by metal cations in a concentration-dependent manner as measured by ThT fluorescence spectroscopy.	thioflavin T	162-165	AA1	Homo sapiens	52-60
7977635-7	1994	With the use of electron microscopy and a thioflavin T assay for fibril formation we found that apo E and apo E4 in particular enhance this spontaneous fibrillogenesis of A beta peptides under the in vitro conditions used.	thioflavin T	42-54	apolipoprotein E	Homo sapiens	96-101
8955102-13	1996	Polymerized MAP-2c and the microtubule binding region fragment readily bound thioflavin-S, a dye that stains paired helical filaments in the histochemical diagnosis of Alzheimer"s disease.	thioflavin T	77-89	microtubule associated protein 2	Homo sapiens	12-18
8954102-4	1996	MAP-2 MTBR polymers bind thioflavin-S, a dye used to histochemically localize Alzheimer neurofibrillary tangles.	thioflavin T	25-37	microtubule associated protein 2	Homo sapiens	0-5
8593893-4	1996	C1q immunostaining was colocalized with nearly all thioflavine-positive plaques, while C1q was not detected in beta-amyloid immunopositive plaques which were thioflavine-negative.	thioflavin T	51-62	complement C1q A chain	Homo sapiens	0-3
8532111-5	1995	Thioflavine S and electron microscopic analysis confirmed that injected A beta 1-40 formed 7-9 nm AD type amyloid fibrils in the cultures.	thioflavin T	0-13	amyloid beta precursor protein	Homo sapiens	72-78
7852387-3	1995	The single mutation of valine 18 to alanine induces a significant increment of the alpha-helical content of A beta, determined by Fourier transform infrared spectroscopy and circular dichroism and dramatically diminishes fibrillogenesis, measured by turbidity, thioflavine T binding, Congo red staining, and electron microscopic examination.	thioflavin T	261-274	amyloid beta precursor protein	Homo sapiens	108-114
8791894-4	1996	This overexpression of beta PP, was concomitant with formation of many A beta nonfibrillar (thioflavine-negative) plaques in the neuropil.	thioflavin T	92-103	amyloid beta precursor protein	Homo sapiens	23-30
7639340-3	1995	Analyzing AD tissue sections single and double stained with anti-A beta antibodies and thioflavin S (thioS) by bright field, fluorescence, and confocal microscopy revealed that spherical plaque cores consist of a thioS-positive center and an anti-A beta antibody immunoreactive rim.	thioflavin T	213-218	amyloid beta precursor protein	Homo sapiens	65-71
7639340-8	1995	A beta may become thioS positive by interacting with one or more of its known molecular chaperons, and this may be important for the pathogenesis of AD, given that thioS-positive A beta deposits are associated with neuritic and synaptic damage.	thioflavin T	18-23	amyloid beta precursor protein	Homo sapiens	0-6
7639340-8	1995	A beta may become thioS positive by interacting with one or more of its known molecular chaperons, and this may be important for the pathogenesis of AD, given that thioS-positive A beta deposits are associated with neuritic and synaptic damage.	thioflavin T	164-169	amyloid beta precursor protein	Homo sapiens	0-6
7639340-8	1995	A beta may become thioS positive by interacting with one or more of its known molecular chaperons, and this may be important for the pathogenesis of AD, given that thioS-positive A beta deposits are associated with neuritic and synaptic damage.	thioflavin T	164-169	amyloid beta precursor protein	Homo sapiens	179-185
7977635-7	1994	With the use of electron microscopy and a thioflavin T assay for fibril formation we found that apo E and apo E4 in particular enhance this spontaneous fibrillogenesis of A beta peptides under the in vitro conditions used.	thioflavin T	42-54	apolipoprotein E	Homo sapiens	106-112
7977635-7	1994	With the use of electron microscopy and a thioflavin T assay for fibril formation we found that apo E and apo E4 in particular enhance this spontaneous fibrillogenesis of A beta peptides under the in vitro conditions used.	thioflavin T	42-54	amyloid beta precursor protein	Homo sapiens	171-177
8313943-7	1994	Jun and Fos immunoreactivity were also colocalized with GFAP-positive astrocytes distributed in the cortex of AD and control cases, and surrounding thioflavine-stained plaques in AD brain.	thioflavin T	148-159	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-11
7824054-5	1994	Moreover, we observed a close correspondence between ApoE and thioflavin-positive (i.e., amyloid) plaques suggesting that ApoE may play a critical role in the conversion of beta A4 to its beta-pleated form.	thioflavin T	62-72	apolipoprotein E	Macaca mulatta	122-126
8525803-10	1995	The deposits were thioflavin S and Congo red positive, indicating that the BAP was in a consolidated form.	thioflavin T	18-30	SIL1 nucleotide exchange factor	Homo sapiens	75-78
8197133-2	1994	After a concentration-dependent lag period during in vitro incubations, soluble preparations of synthetic beta AP slowly form fibrillar aggregates that resemble natural amyloid and are measurable by sedimentation and thioflavin T-based fluorescence.	thioflavin T	217-229	serpin family F member 2	Homo sapiens	106-113
8313943-7	1994	Jun and Fos immunoreactivity were also colocalized with GFAP-positive astrocytes distributed in the cortex of AD and control cases, and surrounding thioflavine-stained plaques in AD brain.	thioflavin T	148-159	glial fibrillary acidic protein	Homo sapiens	56-60
1438289-7	1992	Thioflavin S histochemistry suggested accumulations of amyloid in the cerebrovasculature of transgenic mice with the highest expression of the beta APP-C100 transgene.	thioflavin T	0-12	amyloid beta (A4) precursor protein	Mus musculus	143-151
8059599-9	1994	In addition, extracellular heparan sulfate proteoglycan deposits were observed which colocalized with thioflavine S-positive senile plaques in Alzheimer"s disease, Down syndrome and selected Guam dementia cases.	thioflavin T	102-113	CD44 molecule (Indian blood group)	Homo sapiens	27-55
8059599-10	1994	In some cases, heparan sulfate proteoglycan was seen in senile plaques that appeared to be diffuse or primitive plaques that stained weakly with thioflavine.	thioflavin T	145-156	CD44 molecule (Indian blood group)	Homo sapiens	15-43
8292358-2	1994	One hundred percent of animals receiving infusions of synthetic beta-amyloid protein (A beta 1-40) plus a specific heparan sulfate proteoglycan (HSPG) for 1 week or 7 weeks (following 2 week infusions) demonstrated Congo red and thioflavin S-positive deposits adjacent to the infusion site.	thioflavin T	229-241	syndecan 2	Rattus norvegicus	115-143
8292358-2	1994	One hundred percent of animals receiving infusions of synthetic beta-amyloid protein (A beta 1-40) plus a specific heparan sulfate proteoglycan (HSPG) for 1 week or 7 weeks (following 2 week infusions) demonstrated Congo red and thioflavin S-positive deposits adjacent to the infusion site.	thioflavin T	229-241	syndecan 2	Rattus norvegicus	145-149
8402154-3	1993	More of the thioflavine-S-positive senile plaques of the LBVs contained growth associated protein 43 (GAP-43), a marker of neuritic growth and sprouting.	thioflavin T	12-23	growth associated protein 43	Homo sapiens	72-100
8402154-3	1993	More of the thioflavine-S-positive senile plaques of the LBVs contained growth associated protein 43 (GAP-43), a marker of neuritic growth and sprouting.	thioflavin T	12-23	growth associated protein 43	Homo sapiens	102-108
8453378-5	1993	Insulin fibrils converted to a beta-sheet conformation fluoresce intensely with ThT.	thioflavin T	80-83	amyloid beta precursor protein	Homo sapiens	29-35
33803786-5	2021	Using nuclear magnetic resonance spectroscopy, we observed gradual spectral changes in Abeta after a 10 s CAP pretreatment, which also suppressed its fibril formation, as revealed by thioflavin T assay.	thioflavin T	183-195	amyloid beta precursor protein	Homo sapiens	87-92
1759562-5	1991	We have found that the number of AChE-, thioflavine S- and Tau-positive SP that accumulate in the dentate gyrus is positively correlated with the density of thioflavine S-stained neurofibrillary tangles in layers II and III of the entorhinal cortex.	thioflavin T	157-168	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-37
1759562-5	1991	We have found that the number of AChE-, thioflavine S- and Tau-positive SP that accumulate in the dentate gyrus is positively correlated with the density of thioflavine S-stained neurofibrillary tangles in layers II and III of the entorhinal cortex.	thioflavin T	157-168	microtubule associated protein tau	Homo sapiens	59-62
1672808-7	1991	Glutamate-, glutaminase-, and taurine-stained neurons were found to contain neurofibrillary tangles using either double immunofluorescence with tau antisera, double immunoperoxidase stains, or silver and thioflavine S counterstains.	thioflavin T	204-215	microtubule associated protein tau	Homo sapiens	30-33
33778168-4	2021	BP was found to inhibit aggregation of Abeta as revealed by the Thioflavin T (ThT) fluorescence assay and atomic force microscopy (AFM).	thioflavin T	64-76	amyloid beta precursor protein	Homo sapiens	39-44
33778168-4	2021	BP was found to inhibit aggregation of Abeta as revealed by the Thioflavin T (ThT) fluorescence assay and atomic force microscopy (AFM).	thioflavin T	78-81	amyloid beta precursor protein	Homo sapiens	39-44
33809196-4	2021	A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Abeta fibrils with varying potency due to specific structural differences.	thioflavin T	2-14	amyloid beta precursor protein	Homo sapiens	112-117
33809196-4	2021	A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Abeta fibrils with varying potency due to specific structural differences.	thioflavin T	16-19	amyloid beta precursor protein	Homo sapiens	112-117
32638088-5	2020	For thioflavin-based miRNA-21 detection, the excitation and emission wavelengths are set to 425 nm and 490 nm, respectively.	thioflavin T	4-14	microRNA 21	Homo sapiens	21-29
34592066-4	2022	Immunostaining with two types of specific antibodies for Abeta identified the clear presence of Abeta peptides associated with: (1) carcinoma cells and (2) extracellular aggregated amyloid (also revealed by Congo red and thioflavin S staining).	thioflavin T	221-233	amyloid beta (A4) precursor protein	Mus musculus	96-101
33809978-7	2021	We report that DiY cross-linking facilitates tau assembly into tau oligomers that fail to bind thioflavin S, lack beta-sheet structure and prevents their elongation into filaments.	thioflavin T	95-107	microtubule associated protein tau	Homo sapiens	45-48
34896474-2	2022	After they were characterized, the influence of GSH-MoS2 QDs on amyloid aggregation of bovine serum albumin (BSA) was investigated by various analytical methods including thioflavin T fluorescence assay, circular dichroism and transmission electron microscope.	thioflavin T	171-183	albumin	Homo sapiens	94-107
34927250-3	2022	To assess the effect of autoclaving (AC) or gamma (gamma)-ray irradiation on Abeta pathology transmission, we evaluated the seeding effect of Abeta aggregates using thioflavin T (ThT) assays and high-speed atomic force microscopy (HS-AFM) and investigated the structural changes in the Abeta aggregates after treatment with AC or gamma-ray irradiation using ThT assays, circular dichroism (CD) spectroscopy, and electron microscopy (EM).	thioflavin T	165-177	amyloid beta precursor protein	Homo sapiens	142-147
34927250-3	2022	To assess the effect of autoclaving (AC) or gamma (gamma)-ray irradiation on Abeta pathology transmission, we evaluated the seeding effect of Abeta aggregates using thioflavin T (ThT) assays and high-speed atomic force microscopy (HS-AFM) and investigated the structural changes in the Abeta aggregates after treatment with AC or gamma-ray irradiation using ThT assays, circular dichroism (CD) spectroscopy, and electron microscopy (EM).	thioflavin T	179-182	amyloid beta precursor protein	Homo sapiens	142-147
34948195-6	2021	Using thioflavin and seeding polymerization assays, in addition to electron microscopy, we found that EA could dramatically reduce alpha-syn aggregation.	thioflavin T	6-16	synuclein alpha	Homo sapiens	131-140
34911929-6	2021	We quantitatively measure the decrease in dilute phase concentration as the LLPS of alpha-synuclein is followed by the formation of Thioflavin-T positive amyloid aggregates.	thioflavin T	132-144	synuclein alpha	Homo sapiens	84-99
34339840-6	2021	Specifically, the aggregation of phosphorylated full-length TDP-43 protein (pS410) was monitored by transmission electron microscopy (TEM), turbidity absorbance, and thioflavin (ThT).	thioflavin T	166-176	TAR DNA binding protein	Homo sapiens	60-66
34944028-9	2021	Experiments performed by quenching assay, docking, and Thioflavin T assay further established that the main forces are hydrogen Van der Waals and some non-negligible hydrophobic forces, affecting the lag phase of tau protein kinetics.	thioflavin T	55-67	microtubule associated protein tau	Homo sapiens	213-216
34298087-9	2021	Consistent with its chaperone activity, thioflavin T binding assays clearly showed a modulatory effect of clusterin on ABri and ADan aggregation/fibrillization properties.	thioflavin T	40-52	clusterin	Homo sapiens	106-115
34821199-4	2021	Co-incubation and post-incubation of lysozyme with copper salts reduced the fluorescence signal of thioflavin T with an increment in the intrinsic fluorescence of the protein.	thioflavin T	99-111	lysozyme	Homo sapiens	37-45
34927250-4	2022	The ThT assays and HS-AFM showed that the seeding effect of Abeta aggregates was inactivated by AC at different temperatures, exposure times, and concentrations of Abeta aggregates during treatment with AC.	thioflavin T	4-7	amyloid beta precursor protein	Homo sapiens	60-65
34927250-4	2022	The ThT assays and HS-AFM showed that the seeding effect of Abeta aggregates was inactivated by AC at different temperatures, exposure times, and concentrations of Abeta aggregates during treatment with AC.	thioflavin T	4-7	amyloid beta precursor protein	Homo sapiens	164-169
34927250-5	2022	The results of the ThT fluorescence and CD spectral patterns of the autoclaved Abeta aggregates indicate that AC reduced beta-sheet-rich structures in Abeta aggregates.	thioflavin T	19-22	amyloid beta precursor protein	Homo sapiens	151-156
34718942-4	2021	In the present article, we report preliminary analyses of interactions between amyloid-beta and hydroxyapatite-cholesterol composites using Thioflavin-T binding kinetics, solid-state NMR and transmission electron microscopy (TEM).	thioflavin T	140-150	amyloid beta precursor protein	Homo sapiens	79-91
34718942-5	2021	Thioflavin-T fluorescence kinetics shows that amyloid-beta (1-42) aggregates only under certain conditions of concentration of cholesterol in the hydroxyapatite-cholesterol composites prepared by two different methods.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	46-58
34450412-5	2021	The complex shows high sensitivity to fibrillar insulin with a limit of detection of 0.85 muM and binding affinity of 12.40 +- 1.84 muM which is comparable to those of Thioflavin T and Congo red, with the advantage of minimizing background fluorescence, absorption of light by biomolecules, and light scattering from physiologic salts in the medium.	thioflavin T	168-180	insulin	Homo sapiens	48-55
34986530-5	2021	The beta-amyloid protein (Abeta) depositions in cortex and hippocampal CA1 area of mice were detected by thioflavin T staining.	thioflavin T	105-117	amyloid beta (A4) precursor protein	Mus musculus	26-31
34881008-4	2021	Secondly, we detect the decrease in fluorescence of the G4-selective dyes thioflavin-T and Zn-PPIX bound to various DNA G4 sequences following the addition of cage 1.	thioflavin T	74-86	cancer antigen 1	Homo sapiens	159-165
34260251-2	2021	When vials containing insulin were subjected to mechanical shock or when ultrasound was applied to the vials, the resulting cavitation events induced formation of insulin amyloid fibril nuclei that were detected by transmission electron microscopy and quantified by fluorescence spectroscopy following staining with the amyloid-sensitive dye thioflavin-T.	thioflavin T	342-354	insulin	Homo sapiens	22-29
34309760-6	2021	Thioflavin T assays and electron microscopy demonstrated a decreased potential of pGlu79-alpha-synuclein to form fibrils.	thioflavin T	0-12	synuclein alpha	Homo sapiens	89-104
34445262-6	2021	By using amyloid kinetic analysis, monitored by thioflavin-T fluorescence, and AFM imaging, we found that S100A9 co-aggregation with these compounds does not hinder amyloid formation but leads to morphological changes in the amyloid fibrils, manifested in fibril thickening.	thioflavin T	48-60	S100 calcium binding protein A9	Homo sapiens	106-112
34232542-5	2021	The effect of IMRCs on amyloid-beta (Abeta)-related pathology was detected by thioflavin-S staining and Western blot.	thioflavin T	78-90	amyloid beta (A4) precursor protein	Mus musculus	37-42
34494815-4	2021	The commercial fluorescent probe thioflavin-T (ThT) is used to image Abeta; however, because of its short emission wavelength and poor BBB penetration, ThT can only be used in vitro.	thioflavin T	33-45	histocompatibility 2, class II antigen A, beta 1	Mus musculus	69-74
34494815-4	2021	The commercial fluorescent probe thioflavin-T (ThT) is used to image Abeta; however, because of its short emission wavelength and poor BBB penetration, ThT can only be used in vitro.	thioflavin T	47-50	histocompatibility 2, class II antigen A, beta 1	Mus musculus	69-74
34494815-5	2021	With this research, based on ThT, we design three fluorescent probes (SZIs) having a longer emission wavelength in order to image Abeta aggregates.	thioflavin T	29-32	histocompatibility 2, class II antigen A, beta 1	Mus musculus	130-135
34604227-7	2021	Biophysical assays combining, Thioflavin-T fluorescence, transmission electronic microscopy, capillary electrophoresis, and mass spectrometry showed that the designed compounds inhibit both the oligomerization and the fibrillization of hIAPP.	thioflavin T	30-42	islet amyloid polypeptide	Homo sapiens	236-241
34612337-5	2021	Based on the results of thioflavin T fluorescence and atomic force microscopy imaging assays, it was shown that SWCNT-COOH can not only effectively inhibit Abeta aggregation, but also depolymerize the mature fibrils of Abeta.	thioflavin T	24-36	amyloid beta precursor protein	Homo sapiens	219-224
34541343-4	2021	Thioflavin T (ThT) assay showed alpha-T3 reduced Abeta aggregation at 10 muM concentration.	thioflavin T	0-12	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	32-40
34541343-4	2021	Thioflavin T (ThT) assay showed alpha-T3 reduced Abeta aggregation at 10 muM concentration.	thioflavin T	14-17	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	32-40
34541343-5	2021	Furthermore, both alpha-T3 and gamma-T3 demonstrated Abeta disaggregation, as shown by the reduction of ThT fluorescence.	thioflavin T	104-107	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	18-26
34432157-7	2021	Subsequently, the 3D-QSAR model was used to predict the inhibitory activities towards alpha-syn aggregation, and the actual inhibitory activities were evaluated by thioflavin-T assay in vitro with the best inhibitory activity reaching 45.08%.	thioflavin T	164-176	synuclein alpha	Homo sapiens	86-95
34432157-10	2021	Based on the best pharmacophore modeling, novel indolinone derivatives were designed and synthesized, and the inhibitory activities for alpha-synuclein aggregation were evaluated by thioflavin-T assay in vitro, which preliminary indicated that five pharmacophore sites (two hydrogen bond acceptors (A), a hydrophobic group (H), and two aromatic rings (R)) in compounds contribute to the inhibitory activities.	thioflavin T	182-194	synuclein alpha	Homo sapiens	136-151
34426645-10	2021	Surprisingly, K321Q and K353Q acetylmimetics altered the conformational structure of P301L/S320F tau to extensively impair Thioflavin S binding.	thioflavin T	123-133	microtubule associated protein tau	Homo sapiens	97-100
34362943-7	2021	Region 62-87 of equine and human alpha-syn peptides was found to be most prone to aggregation according to Tango bioinformatic program and kinetics of aggregation via a thioflavin T fluorescence assay.	thioflavin T	169-181	synuclein alpha	Homo sapiens	33-42
34264642-7	2021	IAPP lipidated at His-18 showed a hastened random coil-to-beta-sheet conformational conversion into fibrillar assemblies with a distinct morphology, a low level of binding to thioflavin T, and a high surface hydrophobicity.	thioflavin T	175-187	islet amyloid polypeptide	Homo sapiens	0-4
34077500-5	2021	Transmission electron microscope and thioflavin T assay revealed that SERPINA3-R124C shortened life time of small soluble oligomer and maintained beta-sheet rich protofibril-like aggregates for longer time compared to that of with SERPINA3-WT.	thioflavin T	37-49	serpin family A member 3	Homo sapiens	70-78
34260251-2	2021	When vials containing insulin were subjected to mechanical shock or when ultrasound was applied to the vials, the resulting cavitation events induced formation of insulin amyloid fibril nuclei that were detected by transmission electron microscopy and quantified by fluorescence spectroscopy following staining with the amyloid-sensitive dye thioflavin-T.	thioflavin T	342-354	insulin	Homo sapiens	163-170
34099032-2	2021	Recently it has been shown that specifically, larger, Thioflavin T-binding Abeta aggregates are associated with increased neuroinflammation and cytokine release.	thioflavin T	54-66	amyloid beta precursor protein	Homo sapiens	75-80
34195724-1	2021	The present study provides evidence that the energy transfer chain consisting of the benzothiazole dye Thioflavin T as an input donor, a phosphonium dye TDV and a squaraine dye SQ4 as mediators, and one of the three squaraines SQ1/2/3 as an output acceptor displays an excellent amyloid-sensing ability when applied to differentiating between the amyloid and non-fibrillized states of insulin.	thioflavin T	103-115	insulin	Homo sapiens	385-392
34190258-2	2021	In the present contribution, we have employed a macrocyclic host molecule, sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD), as a tuning agent for an intensely emissive aggregate assembly of a molecular rotor dye, thioflavin-T (ThT), in the presence of an anionic polyelectrolyte, polystyrene sulfonate (PSS).	thioflavin T	214-226	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	115-122
34190258-2	2021	In the present contribution, we have employed a macrocyclic host molecule, sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD), as a tuning agent for an intensely emissive aggregate assembly of a molecular rotor dye, thioflavin-T (ThT), in the presence of an anionic polyelectrolyte, polystyrene sulfonate (PSS).	thioflavin T	228-231	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	115-122
34323038-4	2021	Thioflavin T assay was done to assess the ability of RD2-NP to bind with Abeta and ex vivo imaging was conducted to evaluate the distribution of RD2-NP in brain lesion sites.	thioflavin T	0-12	peripherin 2	Mus musculus	53-56
34137596-4	2021	Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay.	thioflavin T	172-184	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
34151857-5	2021	METHODS: Size exclusion chromatography, Thioflavin T emission, and circular dichroism spectroscopy were used to isolate structurally defined forms of recombinant, human alpha-synuclein.	thioflavin T	40-52	synuclein alpha	Homo sapiens	169-184
34071254-4	2021	With a set of complementary methods, including thioflavin-T-based aggregation kinetic assays, Tau oligomer-specific dot-blot analysis, and single oligomer/fibril analysis by atomic force microscopy, we demonstrate that PolDIP2 inhibits Tau aggregation and amyloid fibril growth in vitro.	thioflavin T	47-59	DNA polymerase delta interacting protein 2	Homo sapiens	219-226
35452930-2	2022	Herein a gold nanocluster stabilized by Arg-Cys dipeptide (Au(RC)NCs) was synthesized to investigate its disaggregation activity toward Abeta fibrils by using Thioflavin-T (ThT) fluorescence assay and atomic force microscopy.	thioflavin T	159-171	amyloid beta precursor protein	Homo sapiens	136-141
35452930-2	2022	Herein a gold nanocluster stabilized by Arg-Cys dipeptide (Au(RC)NCs) was synthesized to investigate its disaggregation activity toward Abeta fibrils by using Thioflavin-T (ThT) fluorescence assay and atomic force microscopy.	thioflavin T	173-176	amyloid beta precursor protein	Homo sapiens	136-141
35349840-6	2022	The formed amplicon contains a series G-quadruplex structure, which can be combined with Thioflavin T (ThT) to produce fluorescence and achieve high sensitivity label-free detection of APE1.	thioflavin T	89-101	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	185-189
35624629-6	2022	With the assistance of TdT and dGTP, the released trigger DNA with 3"-OH terminal can be elongated to a superlong poly(guanine) sequence, and a notable fluorescence signal was observed in the presence of thioflavin T.	thioflavin T	204-216	DNA nucleotidylexotransferase	Homo sapiens	23-26
35466397-3	2022	Here, we tested recombinantly expressed Abeta42 (Asp1 to Ala42) against synthetic Abeta42 from different suppliers using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), circular dichroism (CD) spectroscopy, thioflavin T aggregation, surface plasmon resonance and MTT cell viability assays.	thioflavin T	233-245	beta-secretase 2	Homo sapiens	49-53
35486137-5	2022	In the presence of thioflavin T (ThT), analytical target ALP was converted in an amplified and activatable fluorescence signal.	thioflavin T	19-31	alkaline phosphatase, placental	Homo sapiens	57-60
35349840-6	2022	The formed amplicon contains a series G-quadruplex structure, which can be combined with Thioflavin T (ThT) to produce fluorescence and achieve high sensitivity label-free detection of APE1.	thioflavin T	103-106	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	185-189
35486137-5	2022	In the presence of thioflavin T (ThT), analytical target ALP was converted in an amplified and activatable fluorescence signal.	thioflavin T	33-36	alkaline phosphatase, placental	Homo sapiens	57-60
35474400-10	2022	The thioflavin T (ThT) fibrillation kinetics study showed that the nanoparticles elicited maximum disaggregation of Abeta fibrils that was depicted by the quenched fluorescence intensity signal.	thioflavin T	4-16	amyloid beta precursor protein	Homo sapiens	116-121
35474400-10	2022	The thioflavin T (ThT) fibrillation kinetics study showed that the nanoparticles elicited maximum disaggregation of Abeta fibrils that was depicted by the quenched fluorescence intensity signal.	thioflavin T	18-21	amyloid beta precursor protein	Homo sapiens	116-121
35514983-6	2022	Calreticulin blocked Abeta fibrillization and modified Abeta oligomerization, as measured by thioflavin T fluorescence and transmission electron microscopy.	thioflavin T	93-105	calreticulin	Homo sapiens	0-12
35327661-10	2022	nAbs-alphaSyn inhibited fibrillation of alphaSyn reported by the Thioflavin T aggregation assay.	thioflavin T	65-75	synuclein alpha	Homo sapiens	5-13
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	34-46	activator of HSP90 ATPase activity 1	Homo sapiens	93-97
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	34-46	heat shock protein 90 alpha family class A member 1	Homo sapiens	120-125
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	34-46	microtubule associated protein tau	Homo sapiens	136-139
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	48-51	activator of HSP90 ATPase activity 1	Homo sapiens	93-97
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	48-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	120-125
35586436-2	2022	Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM.	thioflavin T	48-51	microtubule associated protein tau	Homo sapiens	136-139
35327661-10	2022	nAbs-alphaSyn inhibited fibrillation of alphaSyn reported by the Thioflavin T aggregation assay.	thioflavin T	65-75	synuclein alpha	Homo sapiens	40-48
35401818-3	2022	Methods: By conducting computational modelling to quantitatively fine-tune the twisted intramolecular charge transfer (TICT) tendency of Thioflavin T (ThT) analogues, we developed an ultrasensitive probe AH-2.	thioflavin T	137-149	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	204-208
35234452-5	2022	When lightened by thioflavin T (ThT), beams of fluorescence were emitted to show the presented miRNA-21.	thioflavin T	18-30	microRNA 21	Homo sapiens	95-103
35234452-5	2022	When lightened by thioflavin T (ThT), beams of fluorescence were emitted to show the presented miRNA-21.	thioflavin T	32-35	microRNA 21	Homo sapiens	95-103
35168722-4	2022	The released hairpins further bind the primer to trigger the polymerase-aided PER process for the yield of plenty of G-quadruplex sequences, which then combine with the thioflavin T to drastically enhance its fluorescence for sensing miRNA-122 with a low 49.4 fM detection limit.	thioflavin T	169-181	microRNA 122	Homo sapiens	234-243
35401818-3	2022	Methods: By conducting computational modelling to quantitatively fine-tune the twisted intramolecular charge transfer (TICT) tendency of Thioflavin T (ThT) analogues, we developed an ultrasensitive probe AH-2.	thioflavin T	151-154	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	204-208
35401818-4	2022	AH-2 retained the binding affinity and binding mode of ThT towards Abeta deposits, and exhibited ca 10-fold less background fluorescence and 5-10 folds of improved signal-to-background contrast upon binding Abeta deposits.	thioflavin T	55-58	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	0-4
35013421-5	2022	The first screening, thioflavin T assay, allowed the identification of 30 molecules, among a total of 1262 FDA-approved small compounds, which showed inhibitory effects on alpha-synuclein fibrilization.	thioflavin T	21-33	synuclein alpha	Homo sapiens	172-187
35119275-5	2022	The formation of Abeta fibrils is also confirmed in the measurement solution using a fluorescent dye, thioflavin T, which selectively binds to the Abeta fibrils.	thioflavin T	102-114	amyloid beta precursor protein	Homo sapiens	17-22
35119275-5	2022	The formation of Abeta fibrils is also confirmed in the measurement solution using a fluorescent dye, thioflavin T, which selectively binds to the Abeta fibrils.	thioflavin T	102-114	amyloid beta precursor protein	Homo sapiens	147-152
35615856-9	2022	When HEK293T cells were transfected with inflammasome components NLRP3 or Pyrin, along with ASC, pro-caspase-1, pro-IL-1beta, and B2M, ThT fluorescence intensity increased.	thioflavin T	135-138	caspase 1	Homo sapiens	101-110
35615856-9	2022	When HEK293T cells were transfected with inflammasome components NLRP3 or Pyrin, along with ASC, pro-caspase-1, pro-IL-1beta, and B2M, ThT fluorescence intensity increased.	thioflavin T	135-138	beta-2-microglobulin	Homo sapiens	130-133
3144799-3	1988	We observed different distributions of dystrophic neurites (immunolabelled with anti-PHF or anti-Tau) around thioflavine-stained angiopathic arterioles.	thioflavin T	109-120	microtubule associated protein tau	Homo sapiens	97-100
2513582-3	1989	The earliest alpha 1-antichymotrypsin immunoreactivity was found in cortical perivascular cells before the appearance of either thioflavin S-identifiable amyloid deposits or beta-protein reactivity in vessels.	thioflavin T	128-140	serpin family A member 3	Homo sapiens	13-37
2456021-5	1988	Some neurofilament-positive neurites were not visualized with thioflavin, but almost all tau-positive neurites were colabeled with thioflavin.	thioflavin T	131-141	microtubule associated protein tau	Homo sapiens	89-92
3318271-9	1987	The synthetic cerebrovascular amyloid peptide possesses amyloid-like properties: at neutral pH it forms insoluble aggregates consisting of 5-7-nm fibrils, which form red-green birefringent adducts with Congo red and fluoresce with thioflavine S.	thioflavin T	231-244	amyloid beta precursor protein	Homo sapiens	14-45
2886516-13	1987	Neuritic plaques identified on double label experiments with thioflavin include somatostatin axons but not neurons.	thioflavin T	61-71	somatostatin	Homo sapiens	80-92
6514105-4	1984	Combined with thioflavin-T staining to visualize amyloid, this histochemical technique showed that some of these AChE-containing fibers were present in proximity to deposits of amyloid.	thioflavin T	14-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
3794758-3	1987	The study utilizes a monoclonal antibody to microtubule-associated protein 2 for selective immunocytochemical visualization of dendrites and thioflavin S to visualize SP.	thioflavin T	141-153	microtubule associated protein 2	Homo sapiens	44-76
2413088-7	1985	Double-label studies of NPY-i and thioflavin indicate that NPY-i fibers can participate in neuritic plaque formation although not all neuritic plaques contained NPY-i axons and not all NPY-i axons were associated with plaques.	thioflavin T	34-44	neuropeptide Y	Homo sapiens	59-62
2413088-7	1985	Double-label studies of NPY-i and thioflavin indicate that NPY-i fibers can participate in neuritic plaque formation although not all neuritic plaques contained NPY-i axons and not all NPY-i axons were associated with plaques.	thioflavin T	34-44	neuropeptide Y	Homo sapiens	59-62
2413088-7	1985	Double-label studies of NPY-i and thioflavin indicate that NPY-i fibers can participate in neuritic plaque formation although not all neuritic plaques contained NPY-i axons and not all NPY-i axons were associated with plaques.	thioflavin T	34-44	neuropeptide Y	Homo sapiens	59-62
6505701-4	1984	In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence).	thioflavin T	134-146	choline O-acetyltransferase	Bos taurus	33-58
33634808-0	2021	Fluorescence assay based on the thioflavin T-induced conformation switch of G-quadruplexes for TET1 detection.	thioflavin T	32-44	tet methylcytosine dioxygenase 1	Homo sapiens	95-99
33997868-4	2021	Thioflavin T fluorescence assays demonstrated that fast green FCF could inhibit the fibrillogenesis alpha-synuclein.	thioflavin T	0-12	synuclein alpha	Homo sapiens	100-115
33641228-3	2021	Here, we used ultrafast two-dimensional infrared (2D IR) spectroscopy, thioflavin T binding, and transmission electron microscopy to show that the synthetic BAX alpha9 peptide (alpha9p) forms amyloid aggregates in aqueous environments and on the surfaces of anionic small unilamellar vesicles.	thioflavin T	71-83	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
33641228-3	2021	Here, we used ultrafast two-dimensional infrared (2D IR) spectroscopy, thioflavin T binding, and transmission electron microscopy to show that the synthetic BAX alpha9 peptide (alpha9p) forms amyloid aggregates in aqueous environments and on the surfaces of anionic small unilamellar vesicles.	thioflavin T	71-83	immunoglobulin kappa variable 1D-22 (pseudogene)	Homo sapiens	161-167
34056268-5	2021	KLVFF is a hydrophobic sequence of the pentapeptide that prevented tau aggregation as observed by thioflavin S fluorescence, transmission electron microscopy, and circular dichroism spectroscopy.	thioflavin T	98-108	microtubule associated protein tau	Homo sapiens	67-70
33887213-7	2021	In this study, we have synthesized four analogues of hIAPP (H18R-IAPP, H18K-IAPP, H18A-IAPP and H18E-IAPP) and characterized their aggregation with either insulin or zinc in order to determine the effect of the residue-18 on the insulin-IAPP and zinc-IAPP interactions using a variety of biophysical experiments including thioflavin-T fluorescence, transmission electron microscopy imaging, circular dichroism, and NMR spectroscopy.	thioflavin T	322-334	islet amyloid polypeptide	Homo sapiens	53-58
33895131-0	2021	Tau/Abeta chimera peptides: a Thioflavin-T and MALDI-TOF study of Abeta amyloidosis in the presence of Cu(II) or Zn(II) ions and Total Lipid Brain Extract (TLBE) vesicles.	thioflavin T	30-42	microtubule associated protein tau	Homo sapiens	0-3
33614299-3	2021	When the aggregation of insulin, a model amyloidogenic protein, is tracked using thioflavin-T (ThT), an amyloid specific dye, there is an anomalous occurrence of double-sigmoidal aggregation kinetics.	thioflavin T	95-98	insulin	Homo sapiens	24-31
33582578-9	2021	Respective compounds BS-10 and BS-22 inhibited AChE-induced Abeta1-42 aggregation in thioflavin T-assay at 10 muM and 20 muM, but BS-10 at 10 muM and 20 muM concentrations are found more potent than BS-22.	thioflavin T	85-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
33657201-7	2021	Thioflavin T (ThT) fluorescence and Fourier transform infrared (FTIR) analyses indicated that the nanobubbles induced the change of the glucagon conformation to a beta-sheet structure.	thioflavin T	0-12	glucagon	Homo sapiens	136-144
33657201-7	2021	Thioflavin T (ThT) fluorescence and Fourier transform infrared (FTIR) analyses indicated that the nanobubbles induced the change of the glucagon conformation to a beta-sheet structure.	thioflavin T	14-17	glucagon	Homo sapiens	136-144
33460657-4	2021	Thioflavin-T (ThT) fluorescence assays showed that the binding of EA or PPG could effectively inhibit the nucleation and elongation of PrP fibrilization and reduce the amount of PrP fibrils generated.	thioflavin T	0-12	prion protein	Homo sapiens	135-138
33460657-4	2021	Thioflavin-T (ThT) fluorescence assays showed that the binding of EA or PPG could effectively inhibit the nucleation and elongation of PrP fibrilization and reduce the amount of PrP fibrils generated.	thioflavin T	0-12	prion protein	Homo sapiens	178-181
33460657-4	2021	Thioflavin-T (ThT) fluorescence assays showed that the binding of EA or PPG could effectively inhibit the nucleation and elongation of PrP fibrilization and reduce the amount of PrP fibrils generated.	thioflavin T	14-17	prion protein	Homo sapiens	135-138
33460657-4	2021	Thioflavin-T (ThT) fluorescence assays showed that the binding of EA or PPG could effectively inhibit the nucleation and elongation of PrP fibrilization and reduce the amount of PrP fibrils generated.	thioflavin T	14-17	prion protein	Homo sapiens	178-181
33527970-2	2021	Compounds Tr3, Tr7, Tr12, Tr15, and Tr16 exhibited good effect in inhibiting alpha-syn fibrillogenesis confirmed by Thioflavin-T assay and fluorescence microscopy and alpha-syn disaggregation confirmed by fluorescence microscopy.	thioflavin T	116-128	nuclear receptor subfamily 4 group A member 1	Homo sapiens	10-13
33527970-2	2021	Compounds Tr3, Tr7, Tr12, Tr15, and Tr16 exhibited good effect in inhibiting alpha-syn fibrillogenesis confirmed by Thioflavin-T assay and fluorescence microscopy and alpha-syn disaggregation confirmed by fluorescence microscopy.	thioflavin T	116-128	synuclein alpha	Homo sapiens	77-86
33395622-4	2021	Several peptides exhibited promising protection against Abeta aggregation-mediated-neurotoxicity in PC-12 cells at doses ranged between 10 muM and 0.1 muM, further confirmed by the thioflavin-T fluorescence assay.	thioflavin T	181-193	amyloid beta precursor protein	Rattus norvegicus	56-61
33614299-0	2021	Exploring the occurrence of thioflavin-T-positive insulin amyloid aggregation intermediates.	thioflavin T	28-40	insulin	Homo sapiens	50-57
33614299-3	2021	When the aggregation of insulin, a model amyloidogenic protein, is tracked using thioflavin-T (ThT), an amyloid specific dye, there is an anomalous occurrence of double-sigmoidal aggregation kinetics.	thioflavin T	81-93	insulin	Homo sapiens	24-31
33562625-1	2021	We present an integrated delivery technology herein employing the aerosolized method to repurpose thioflavin S for imaging amyloid beta (Abeta) deposits in the retina as a surrogate of Abeta in the brain for early detection of Alzheimer"s disease.	thioflavin T	98-110	amyloid beta (A4) precursor protein	Mus musculus	137-142
33562625-4	2021	Furthermore, the fluorescent signal depicted from thioflavin S corroborates with Abeta immunohistochemistry staining information.	thioflavin T	50-62	amyloid beta (A4) precursor protein	Mus musculus	81-86
33502585-7	2021	Compared with the commonly used thioflavin T fluorescence assay, this method provided higher sensitivity to the formation of Abeta oligomer at the very early assembly stage.	thioflavin T	32-44	amyloid beta precursor protein	Rattus norvegicus	125-130
33417459-8	2021	However, as seen by thioflavin-T fluorescence, TH aggregated at this more acidic pH.	thioflavin T	20-32	tyrosine hydroxylase	Homo sapiens	47-49
33754065-16	2021	The therapeutic potential of US-HA-Exo/FUS delivery was demonstrated by a decrease in thioflavin-S-positive amyloid plaques and Abeta immuno-staining, a therapeutic target for AD in APP/PS1 transgenic mice.	thioflavin T	86-98	5'-3' exoribonuclease 1	Mus musculus	35-38
33681712-9	2021	These anti-cytotoxic effects can be derived from the inhibitory functions of borrelidins against the Abeta aggregation as shown in thioflavin T and gel electrophoretic analyses.	thioflavin T	131-143	amyloid beta (A4) precursor protein	Mus musculus	101-106
33202269-4	2021	Herein, we report a simple, selective, sensitive and label-free fluorescence detection scheme for Thrombin which is based on the interaction between Thrombin and a fluorescent complex of Heparin with a molecular rotor dye, Thioflavin-T.	thioflavin T	223-235	coagulation factor II, thrombin	Homo sapiens	98-106
33202269-4	2021	Herein, we report a simple, selective, sensitive and label-free fluorescence detection scheme for Thrombin which is based on the interaction between Thrombin and a fluorescent complex of Heparin with a molecular rotor dye, Thioflavin-T.	thioflavin T	223-235	coagulation factor II, thrombin	Homo sapiens	149-157
33202269-5	2021	The detection scheme exploits selective interaction between cationic Thrombin and anionic Heparin to modulate the monomer-aggregate equilibrium of the Thioflavin-T-Heparin system.	thioflavin T	151-163	coagulation factor II, thrombin	Homo sapiens	69-77
33452414-2	2021	In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation.	thioflavin T	66-78	amyloid beta (A4) precursor protein	Mus musculus	58-63
33452414-2	2021	In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation.	thioflavin T	80-83	amyloid beta (A4) precursor protein	Mus musculus	58-63
33452414-3	2021	In this study, we investigated the possibility that a commonly used Abeta-expressing AD model mouse, 5XFAD, generates ThS-positive aggregates of beta-sheet structures in addition to Abeta fibrils.	thioflavin T	118-121	amyloid beta (A4) precursor protein	Mus musculus	68-73
33452414-4	2021	To test this hypothesis, brain sections of male and female 5XFAD mice were double-stained with ThS and monoclonal antibodies against Abeta, tau, or alpha-synuclein, all of which aggregates are detected by ThS.	thioflavin T	205-208	synuclein, alpha	Mus musculus	148-163
33452414-6	2021	Upon administration of a small molecule that exclusively disaggregates Abeta to 5XFAD mice for six weeks, we found that the reduction level of plaques was smaller in brain sections stained by ThS compared to an anti-Abeta antibody.	thioflavin T	192-195	amyloid beta (A4) precursor protein	Mus musculus	71-76
33452414-7	2021	Our findings implicate that the use of ThS complicates the quantification of amyloid plaques and the assessment of Abeta-targeting drugs in 5XFAD mice.	thioflavin T	39-42	amyloid beta (A4) precursor protein	Mus musculus	115-120
33431932-5	2021	UBQLN4 displays heightened aggregation propensity over the other ubiquilins and, like amyloids, UBQLN4 forms ThioflavinT-positive fibrils in vitro.	thioflavin T	109-120	ubiquilin 4	Homo sapiens	0-6
33431932-5	2021	UBQLN4 displays heightened aggregation propensity over the other ubiquilins and, like amyloids, UBQLN4 forms ThioflavinT-positive fibrils in vitro.	thioflavin T	109-120	ubiquilin 4	Homo sapiens	96-102
32770501-10	2021	Thioflavin binding, dynamic light scattering, and transmission electron microscopy protocols are described as complementary methods to detect Abeta aggregation kinetics, aggregate sizes, and morphologies of observed aggregates.	thioflavin T	0-10	amyloid beta precursor protein	Homo sapiens	142-147
32471773-6	2021	RESULTS: Compound 1 displays characteristics of Abeta binding dyes, such as thioflavin-S, in that it labels both parenchymal Abeta plaques and CAA when applied to histological sections from both a transgenic APP/PS1 mouse model of Abeta amyloidosis and AD brain.	thioflavin T	76-88	amyloid beta (A4) precursor protein	Mus musculus	48-53
32471773-6	2021	RESULTS: Compound 1 displays characteristics of Abeta binding dyes, such as thioflavin-S, in that it labels both parenchymal Abeta plaques and CAA when applied to histological sections from both a transgenic APP/PS1 mouse model of Abeta amyloidosis and AD brain.	thioflavin T	76-88	amyloid beta precursor protein	Homo sapiens	125-130
33338256-8	2021	Corroborating these in vivo findings, synthetic Abeta-S8C dimers inhibited fibril formation of wild-type Abeta also in vitro, seen by an increased half-time in the ThT assay.	thioflavin T	164-167	amyloid beta precursor protein	Homo sapiens	48-53
32975927-8	2020	Insights into the aggregation properties of htt-ex1 derivatives-as well as into the nucleation process itself-were obtained using fluorescence correlation spectroscopy (FCS) and a novel thioflavin-T (ThT) protocol that allows quantitation of htt-ex1 assembly intermediates.Using these tools, we quantified physical states of htt-ex1 at different growth times in mammalian PC12 cells engineered for inducible expression of both normal and expanded polyQ repeat length versions of htt-ex1.	thioflavin T	186-198	huntingtin	Homo sapiens	44-47
33317395-4	2020	The role of cysteine residues in Tau aggregation has been studied by in-vitro aggregation assay that was measured by Thioflavin S fluorescence to observe the kinetics of aggregation.	thioflavin T	117-127	microtubule associated protein tau	Homo sapiens	33-36
33201685-0	2020	Identifying Insulin Fibril Conformational Differences by Thioflavin-T Binding Characteristics.	thioflavin T	57-69	insulin	Homo sapiens	12-19
33287899-4	2020	Here we show that overexpression of CLAC precursor (CLAC-P) in the brains of APP transgenic mice results in a significant remodeling of amyloid pathology, i.e., reduction in diffuse-type amyloid plaques and an increase in compact plaques laden with thioflavin S-positive amyloid cores.	thioflavin T	249-261	collagen, type XXV, alpha 1	Mus musculus	52-58
33194521-2	2020	Thioflavin-T assay for assessing amyloid-beta (Abeta) aggregation of these alkaloids exhibited inhibitions at 60.321% +- 2.61 (50 muM) for isomitraphylline and 43.17% +- 3.48 (50 muM) for mitraphylline.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	33-45
33194521-2	2020	Thioflavin-T assay for assessing amyloid-beta (Abeta) aggregation of these alkaloids exhibited inhibitions at 60.321% +- 2.61 (50 muM) for isomitraphylline and 43.17% +- 3.48 (50 muM) for mitraphylline.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	47-52
32961434-5	2020	Compounds A1, A2 A4, A8 and A9 showed a significant lowering of the alpha-syn fibril formation during Thioflavin-T assay and fluorescence microscopy.	thioflavin T	102-114	synuclein alpha	Homo sapiens	68-77
33084705-3	2020	The self-assembly of NKB and its mutant species was investigated by Thioflavin T (ThT) fluorescence assay and atomic force microscopy (AFM), and at the same time, the effect of Cu2+ on the aggregation of NKB was studied.	thioflavin T	68-80	tachykinin precursor 3	Rattus norvegicus	21-24
33084705-3	2020	The self-assembly of NKB and its mutant species was investigated by Thioflavin T (ThT) fluorescence assay and atomic force microscopy (AFM), and at the same time, the effect of Cu2+ on the aggregation of NKB was studied.	thioflavin T	82-85	tachykinin precursor 3	Rattus norvegicus	21-24
33114506-1	2020	We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N3-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence.	thioflavin T	26-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	190-195
33114506-1	2020	We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N3-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence.	thioflavin T	40-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	190-195
33114506-1	2020	We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N3-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence.	thioflavin T	102-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	190-195
32975927-8	2020	Insights into the aggregation properties of htt-ex1 derivatives-as well as into the nucleation process itself-were obtained using fluorescence correlation spectroscopy (FCS) and a novel thioflavin-T (ThT) protocol that allows quantitation of htt-ex1 assembly intermediates.Using these tools, we quantified physical states of htt-ex1 at different growth times in mammalian PC12 cells engineered for inducible expression of both normal and expanded polyQ repeat length versions of htt-ex1.	thioflavin T	200-203	huntingtin	Homo sapiens	44-47
33053340-4	2020	A patient-derived R140Q FMRP point mutation mislocalizes PKA-SPARK activity, whereas deletion of the RNA-binding arginine-glycine-glycine (RGG) box (hFMRP-DeltaRGG) produces fibrillar PKA-SPARK assemblies colocalizing with ribonucleoprotein (RNP) and aggregation (thioflavin T) markers, demonstrating fibrillar partitioning of cytosolic protein aggregates.	thioflavin T	264-276	fragile X messenger ribonucleoprotein 1	Homo sapiens	149-154
33049998-4	2020	By applying a thioflavin T (ThT) fluorescence assay, we have found that CacyBP/SIP protects alpha-synuclein from aggregation and that the fragment overlapping the N-terminal part and the CS domain of CacyBP/SIP is crucial for this activity.	thioflavin T	28-31	calcyclin binding protein	Homo sapiens	72-78
33049998-4	2020	By applying a thioflavin T (ThT) fluorescence assay, we have found that CacyBP/SIP protects alpha-synuclein from aggregation and that the fragment overlapping the N-terminal part and the CS domain of CacyBP/SIP is crucial for this activity.	thioflavin T	14-26	calcyclin binding protein	Homo sapiens	72-78
33008896-0	2020	Novel self-replicating alpha-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons.	thioflavin T	62-65	synuclein, alpha	Mus musculus	23-38
33008896-2	2020	Experimentally, various alpha-syn fibril polymorphs have been obtained from distinct fibrillization conditions by altering the medium constituents and were selected by amyloid monitoring using the probe thioflavin T (ThT).	thioflavin T	203-215	synuclein, alpha	Mus musculus	24-33
33008896-2	2020	Experimentally, various alpha-syn fibril polymorphs have been obtained from distinct fibrillization conditions by altering the medium constituents and were selected by amyloid monitoring using the probe thioflavin T (ThT).	thioflavin T	217-220	synuclein, alpha	Mus musculus	24-33
32768884-7	2020	PAP also reduced the expression of matrix metalloproteinase-3 (MMP-3), and the MMP3-positive area co-labeled with thioflavin-S.	thioflavin T	114-126	matrix metallopeptidase 3	Mus musculus	79-83
32728889-7	2020	Cell-free thioflavin T assays were used to monitor hIAPP aggregation kinetics in the presence and absence of IL-1beta.	thioflavin T	10-22	islet amyloid polypeptide	Homo sapiens	51-56
33049998-4	2020	By applying a thioflavin T (ThT) fluorescence assay, we have found that CacyBP/SIP protects alpha-synuclein from aggregation and that the fragment overlapping the N-terminal part and the CS domain of CacyBP/SIP is crucial for this activity.	thioflavin T	28-31	calcyclin binding protein	Homo sapiens	200-206
32673279-5	2020	As the concentration of artemin was increased up to 4 mug/ml, a decrease in fibril formation of alpha-synuclein was observed using thioflavin T (ThT) fluorescence and congo red (CR) assay.	thioflavin T	131-143	synuclein alpha	Homo sapiens	96-111
32917811-6	2020	In contrast to the soluble N-terminal portion, the C-terminal tyrosine-rich fragment of ALIX-PRD forms amyloid fibrils and viscous gels validated using dye-binding assays with amyloid-specific probes, congo red and thioflavin T (ThT), and visualized by transmission electron microscopy.	thioflavin T	215-227	programmed cell death 6 interacting protein	Homo sapiens	88-92
32917811-6	2020	In contrast to the soluble N-terminal portion, the C-terminal tyrosine-rich fragment of ALIX-PRD forms amyloid fibrils and viscous gels validated using dye-binding assays with amyloid-specific probes, congo red and thioflavin T (ThT), and visualized by transmission electron microscopy.	thioflavin T	229-232	programmed cell death 6 interacting protein	Homo sapiens	88-92
32673279-5	2020	As the concentration of artemin was increased up to 4 mug/ml, a decrease in fibril formation of alpha-synuclein was observed using thioflavin T (ThT) fluorescence and congo red (CR) assay.	thioflavin T	145-148	synuclein alpha	Homo sapiens	96-111
32786307-5	2020	In addition, AMF binds to Abeta fibrils with a high affinity (Ki = 287 +- 20 nM) - as revealed by a competition thioflavin T (ThT) assay, and specifically labels the amyloid plaques ex vivo in the brain sections of transgenic AD mice - as confirmed via immunostaining with an Abeta antibody.	thioflavin T	112-124	amyloid beta (A4) precursor protein	Mus musculus	26-31
32887693-4	2020	Further, PFF-mediated protein aggregation was exacerbated by Ubc9-RNAi in Thioflavin T staining, compared to NC1 controls.	thioflavin T	74-86	ubiquitin-conjugating enzyme E2I	Mus musculus	61-65
32839791-4	2020	Importantly, a target analogue DNA complex can be generated in such processes for recycling the branch migration reactions for the production of substantial amounts of G-quadruplexes, which can bind the thioflavin T dye to show significantly intensified fluorescence for detecting MUC1 with a low detection limit of 2.8 nM without the involvement of any labels or enzymes.	thioflavin T	203-215	mucin 1, cell surface associated	Homo sapiens	281-285
32619650-6	2020	Thioflavin S staining was used to observe Abeta deposition.	thioflavin T	0-12	amyloid beta (A4) precursor protein	Mus musculus	42-47
32786307-5	2020	In addition, AMF binds to Abeta fibrils with a high affinity (Ki = 287 +- 20 nM) - as revealed by a competition thioflavin T (ThT) assay, and specifically labels the amyloid plaques ex vivo in the brain sections of transgenic AD mice - as confirmed via immunostaining with an Abeta antibody.	thioflavin T	126-129	amyloid beta (A4) precursor protein	Mus musculus	26-31
32701214-5	2020	Here, we examined potential inhibitors of superoxide dismutase 1 (SOD1) using ThT-fluorescence including the different phases of fluorescence change and added a parallel screen of SOD1 activity as a potential proxy for compound toxicity.	thioflavin T	78-81	superoxide dismutase 1	Homo sapiens	42-64
32701214-5	2020	Here, we examined potential inhibitors of superoxide dismutase 1 (SOD1) using ThT-fluorescence including the different phases of fluorescence change and added a parallel screen of SOD1 activity as a potential proxy for compound toxicity.	thioflavin T	78-81	superoxide dismutase 1	Homo sapiens	66-70
32488355-6	2020	The results of thioflavin T-assay also elicited anti-Abeta aggregation activity by JFD03947.	thioflavin T	15-25	amyloid beta precursor protein	Homo sapiens	53-58
32736670-0	2020	The Yarrowia lipolytica orthologs of Sup35p assemble into thioflavin T-negative amyloid fibrils.	thioflavin T	58-70	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	37-43
32859090-3	2020	In this work, we focused on the investigation of the mechanisms, which underlay the difference in sensitivity of ThT fluorescence intensity and lifetime to the formation of protein aggregates during fibrillation by the example of insulin and during binding to globular proteins.	thioflavin T	113-116	insulin	Homo sapiens	230-237
32579329-7	2020	Moreover, MG-2119 inhibited alpha-syn aggregation as revealed by Thioflavin T (ThT) assay and dynamic light scattering (DLS) measurements.	thioflavin T	65-77	synuclein alpha	Homo sapiens	28-37
32417755-4	2020	Using an array of approaches, including thioflavin T fluorescence assays and sedimentation analysis, we found that the N-terminal region of Hsp27 and the terminal regions of alphaB-crystallin are important for delaying amyloid fibril nucleation and for disaggregating mature apolipoprotein C-II fibrils.	thioflavin T	40-52	heat shock protein family B (small) member 1	Homo sapiens	140-145
32665013-4	2020	Although both genotypes developed tau pathology, Fyn KO developed fewer neurofibrillary tangles on Bielschowsky and Thioflavin S stained sections and showed lower levels of phosphorylated tau.	thioflavin T	116-128	Fyn proto-oncogene	Mus musculus	49-52
32496046-1	2020	Thioflavin T (ThT) is a popular fluorescent dye for detecting amyloid, a protein aggregate with a beta-sheet-rich structure that causes many neurodegenerative diseases.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	96-102
32496046-1	2020	Thioflavin T (ThT) is a popular fluorescent dye for detecting amyloid, a protein aggregate with a beta-sheet-rich structure that causes many neurodegenerative diseases.	thioflavin T	14-17	amyloid beta precursor protein	Homo sapiens	96-102
32850841-5	2020	Using Thioflavin-T fluorescence and transmission electron microscopy, we show here for the first time that PDI can break down nascent fibrils of alpha-synuclein.	thioflavin T	6-18	prolyl 4-hydroxylase subunit beta	Homo sapiens	107-110
32850841-5	2020	Using Thioflavin-T fluorescence and transmission electron microscopy, we show here for the first time that PDI can break down nascent fibrils of alpha-synuclein.	thioflavin T	6-18	synuclein alpha	Homo sapiens	145-160
32579329-7	2020	Moreover, MG-2119 inhibited alpha-syn aggregation as revealed by Thioflavin T (ThT) assay and dynamic light scattering (DLS) measurements.	thioflavin T	79-82	synuclein alpha	Homo sapiens	28-37
32402244-11	2020	This observation and the significantly lower thioflavin T fluorescence emitted by medin aggregates compared to amyloid-beta fibrils, along with the absence of amyloid fibers in the AFM and transmission electron microscopy images, suggest that medin aggregation into pores follows a nonamyloidogenic pathway.	thioflavin T	45-57	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	82-87
32544592-4	2021	While the fluorescence response of extrinsic fluorescent probes such as Thioflavin-T have become workhorse tools for characterizing large Abeta aggregates in solution, it is widely accepted that these methods suffer from many important drawbacks, including an insensitivity to oligomeric species.	thioflavin T	72-84	amyloid beta precursor protein	Homo sapiens	138-143
31747135-3	2020	Intact or elastase-digested thrombin destabilized Abeta fibril, as demonstrated by thioflavin T assay.	thioflavin T	83-95	coagulation factor II, thrombin	Homo sapiens	28-36
31907497-5	2020	After hyperspectral Raman mapping, Abeta plaques were visualized using Thioflavin-S staining on the exact same tissue sections.	thioflavin T	71-83	amyloid beta precursor protein	Homo sapiens	35-40
32207466-4	2020	Here, we investigated the aggregation kinetics of Tau and disease-associated P301L and P301S mutants by combined thioflavin T assay and kinetic modeling, which revealed the rate constants of individual microscopic steps in the process of amyloid formation.	thioflavin T	113-125	microtubule associated protein tau	Homo sapiens	50-53
31759017-4	2020	Thioflavin-T (ThT) fluorescence assay, dynamic light scattering (DLS) and atomic force microscopy (AFM) images showed that cichoric acid inhibited the aggregation and fibrillation of hIAPP in a dosage-dependent manner.	thioflavin T	0-12	islet amyloid polypeptide	Homo sapiens	183-188
31945312-8	2020	Thioflavin T fluorescence assay, quantitative chromatographic analysis of the insoluble fraction and transmission electron microscopy allowed for a deeper insight into the SAA aggregation process and the morphology of aggregates.	thioflavin T	0-12	serum amyloid A1	Homo sapiens	172-175
32183067-4	2020	Here, we show that COS inhibited the aggregation of hIAPP and disassembled preformed hIAPP fibrils in a dose-dependent manner by thioflavin T fluorescence assay, circular dichroism spectroscopy, and transmission electron microscope.	thioflavin T	129-141	islet amyloid polypeptide	Homo sapiens	52-57
32183067-4	2020	Here, we show that COS inhibited the aggregation of hIAPP and disassembled preformed hIAPP fibrils in a dose-dependent manner by thioflavin T fluorescence assay, circular dichroism spectroscopy, and transmission electron microscope.	thioflavin T	129-141	islet amyloid polypeptide	Homo sapiens	85-90
32458857-0	2020	Driving force to detect Alzheimer"s disease biomarkers: application of a thioflavine T@Er-MOF ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid beta-protein and acetylcholine.	thioflavin T	73-84	presenilin 1	Homo sapiens	148-160
32458857-5	2020	Firstly, with the spilted DNA strategy, this is the first time that ThT@Er-MOF can be applied in the label-free detection of SSODN (part of the presenilin 1 gene).	thioflavin T	68-71	presenilin 1	Homo sapiens	144-156
32458857-6	2020	Secondly, for the detection of Abeta, because ThT can be specifically combined with Abeta and has an excellent characteristic fluorescence band, the dual-emission ThT@Er-MOF sensor can be selectively applied to detect Abeta over the analog protein, which shows far more sensitivity than other Abeta sensors.	thioflavin T	46-49	amyloid beta precursor protein	Homo sapiens	31-36
32458857-6	2020	Secondly, for the detection of Abeta, because ThT can be specifically combined with Abeta and has an excellent characteristic fluorescence band, the dual-emission ThT@Er-MOF sensor can be selectively applied to detect Abeta over the analog protein, which shows far more sensitivity than other Abeta sensors.	thioflavin T	163-166	amyloid beta precursor protein	Homo sapiens	31-36
32458857-6	2020	Secondly, for the detection of Abeta, because ThT can be specifically combined with Abeta and has an excellent characteristic fluorescence band, the dual-emission ThT@Er-MOF sensor can be selectively applied to detect Abeta over the analog protein, which shows far more sensitivity than other Abeta sensors.	thioflavin T	163-166	amyloid beta precursor protein	Homo sapiens	84-89
32458857-6	2020	Secondly, for the detection of Abeta, because ThT can be specifically combined with Abeta and has an excellent characteristic fluorescence band, the dual-emission ThT@Er-MOF sensor can be selectively applied to detect Abeta over the analog protein, which shows far more sensitivity than other Abeta sensors.	thioflavin T	163-166	amyloid beta precursor protein	Homo sapiens	84-89
32458857-6	2020	Secondly, for the detection of Abeta, because ThT can be specifically combined with Abeta and has an excellent characteristic fluorescence band, the dual-emission ThT@Er-MOF sensor can be selectively applied to detect Abeta over the analog protein, which shows far more sensitivity than other Abeta sensors.	thioflavin T	163-166	amyloid beta precursor protein	Homo sapiens	84-89
32429337-4	2020	In this study, we showed the potential of lactulose and melibiose to inhibit alpha-synuclein aggregation using biochemical thioflavin T fluorescence, cryogenic transmission electron microscopy (cryo-TEM) and prokaryotic split Venus complementation assays.	thioflavin T	123-135	synuclein, alpha	Mus musculus	77-92
32571190-0	2020	alpha-Synuclein Overexpression in SH-SY5Y Human Neuroblastoma Cells Leads to the Accumulation of Thioflavin S-positive Aggregates and Impairment of Glycolysis.	thioflavin T	97-109	synuclein alpha	Homo sapiens	0-15
32005664-5	2020	Further, recombinant OTUB1 exhibited high thioflavin-T and Congo red binding and increased beta-sheet formation upon heat induction.	thioflavin T	42-52	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	21-26
32005664-7	2020	OTUB1 formed inclusions in neuronal cells and co-localized with thioflavin S and with alpha-synuclein during rotenone-induced stress.	thioflavin T	64-76	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	0-5
31785325-8	2020	RESULTS: ThT assay indicated reduction of fibrillation of VA6 by PIMT.	thioflavin T	9-12	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	65-69
31945397-4	2020	Subsequently, thioflavin T binding assay showed that 3 out of 9 studied compounds effectively prevented amyloid transformation of alpha-synuclein with IC50 of 13, 50 and 251 muM.	thioflavin T	14-26	synuclein alpha	Homo sapiens	130-145
32087764-8	2020	The discrimination of Pick disease from Alzheimer disease and chronic traumatic encephalopathy cases is then achieved through the quantitative differences in K12 RT-QuIC assay thioflavin T responses, which correlate with structural properties of the reaction products.	thioflavin T	176-188	protein interacting with PRKCA 1	Homo sapiens	22-26
32121059-5	2020	Conversely, pyridinium polycation, poly(N-ethylvinylpyridinium), switched the mechanism of alpha-synuclein aggregation from amyloidogenic to amorphous, which resulted in the formation of large amorphous aggregates that do not bind with thioflavin T.	thioflavin T	236-248	synuclein alpha	Homo sapiens	91-106
32087764-8	2020	The discrimination of Pick disease from Alzheimer disease and chronic traumatic encephalopathy cases is then achieved through the quantitative differences in K12 RT-QuIC assay thioflavin T responses, which correlate with structural properties of the reaction products.	thioflavin T	176-188	keratin 12	Homo sapiens	158-161
32153351-7	2020	In a cell-free system, FAIM inhibits aggregation of mutant SOD1, and further disassembles and solubilizes established mutant SOD1 protein aggregates, as determined by thioflavin T (ThT), filter trap, and sedimentation assays.	thioflavin T	167-179	Fas apoptotic inhibitory molecule	Homo sapiens	23-27
32153351-7	2020	In a cell-free system, FAIM inhibits aggregation of mutant SOD1, and further disassembles and solubilizes established mutant SOD1 protein aggregates, as determined by thioflavin T (ThT), filter trap, and sedimentation assays.	thioflavin T	181-184	Fas apoptotic inhibitory molecule	Homo sapiens	23-27
32154238-8	2020	These NPs showed a strong inhibitory effect on alphaSYN fibrillization, significantly diminishing alphaSYN fibrillization in vitro compared to untreated alphaSYN using a Thioflavin T assay.	thioflavin T	170-182	synuclein alpha	Homo sapiens	47-55
31952808-7	2020	[R273C]p53 aggregation is disulfide mediated, leading to cross-beta, thioflavin-T-positive aggregates, whereas hydrophobic interactions dominate self-assembly in [R273L]p53, leading to a mixture of amyloid and amorphous aggregates.	thioflavin T	69-81	tumor protein p53	Homo sapiens	7-10
32093427-8	2020	Neuronal accumulation of Thioflavin-S-positive misfolded protein aggregates and drastically increased levels of neuroinflammatory glial fibrillary acidic protein (GFAP)-positive astrocytes and CD11b-positive activated microglia were observed in Idua -/- cortex by confocal fluorescent microscopy.	thioflavin T	25-37	integrin alpha M	Mus musculus	193-198
32027132-6	2020	We test the influence of Cu2+ on the aggregation properties of these amylin analogues with thioflavin T assays.	thioflavin T	91-103	islet amyloid polypeptide	Rattus norvegicus	69-75
31952808-7	2020	[R273C]p53 aggregation is disulfide mediated, leading to cross-beta, thioflavin-T-positive aggregates, whereas hydrophobic interactions dominate self-assembly in [R273L]p53, leading to a mixture of amyloid and amorphous aggregates.	thioflavin T	69-81	tumor protein p53	Homo sapiens	169-172
31616982-4	2020	A novel dimension of this tau RT-QuIC testing was the identification of three disease-associated classes of 4R tau seeds; these classes were revealed by conformational variations in the in vitro amplified tau fibrils as detected by thioflavin T fluorescence amplitudes and FTIR spectroscopy.	thioflavin T	232-244	microtubule associated protein tau	Homo sapiens	26-29
32013170-5	2020	The aggregation of human recombinant alpha-synuclein was investigated using thioflavin-T fluorescence assay.	thioflavin T	76-88	synuclein alpha	Homo sapiens	37-52
31812799-3	2020	A thioflavin T fluorescence assay was first used to determine the fibrillation profile of a GLP-1-like peptide (G48) at conditions being considered to formulate the peptide.	thioflavin T	2-14	glucagon like peptide 1 receptor	Homo sapiens	92-97
31812799-3	2020	A thioflavin T fluorescence assay was first used to determine the fibrillation profile of a GLP-1-like peptide (G48) at conditions being considered to formulate the peptide.	thioflavin T	2-14	deoxyribonuclease 1 like 1	Homo sapiens	112-115
31927055-8	2020	Using thioflavine-S staining and ELISA, we found that Orexin-A promoted Abeta accumulation in APP/PS1 mice.	thioflavin T	6-17	hypocretin	Mus musculus	54-62
31616982-4	2020	A novel dimension of this tau RT-QuIC testing was the identification of three disease-associated classes of 4R tau seeds; these classes were revealed by conformational variations in the in vitro amplified tau fibrils as detected by thioflavin T fluorescence amplitudes and FTIR spectroscopy.	thioflavin T	232-244	microtubule associated protein tau	Homo sapiens	111-114
31616982-4	2020	A novel dimension of this tau RT-QuIC testing was the identification of three disease-associated classes of 4R tau seeds; these classes were revealed by conformational variations in the in vitro amplified tau fibrils as detected by thioflavin T fluorescence amplitudes and FTIR spectroscopy.	thioflavin T	232-244	microtubule associated protein tau	Homo sapiens	111-114
32410038-3	2020	In this chapter, we describe two techniques for the histological detection of Abeta, immunostaining with Abeta antibodies and staining with the amyloid dye thioflavin S, and its quantification using digital imaging.	thioflavin T	156-168	amyloid beta (A4) precursor protein	Mus musculus	78-83
31888771-9	2019	We detect thioflavin S-positive inclusions indicating the presence of mature amyloid aggregates.In conclusion, alpha-synuclein strains seed the aggregation of their cellular counterparts to different extents and spread differentially within the central nervous system yielding distinct propagation patterns.	thioflavin T	10-22	synuclein, alpha	Mus musculus	111-126
32979726-5	2020	RESULTS: Fluorescence microscopy results showed that fluorescence signals of IPBF derivatives corresponded to the thioflavin-T positive amyloid deposits of PrPSc in the brain sections of mouse-adapted bovine spongiform encephalopathy (mBSE)-infected mice.	thioflavin T	114-126	prion protein	Mus musculus	156-161
32186269-5	2020	METHOD: In this work, the influence of Ca2+ and Zn2+ on the beta-casein fibril formation in the absence and presence of HS was investigated by various methods of Thioflavin T fluorescence assay, transmission electron microscopy and intrinsic fluorescence measure.	thioflavin T	162-174	casein beta	Homo sapiens	60-71
31561043-7	2019	Further, 49 also exhibited anti-Abeta aggregation activity in self- and AChE-induced thioflavin T assay, which was ascertained by morphological characterization by atomic force microscopy (AFM).	thioflavin T	85-97	amyloid beta precursor protein	Homo sapiens	32-37
31831836-5	2019	We showed that FXR1 clearly colocalizes in cortical neurons with amyloid-specific dyes Congo-Red, Thioflavines S and T. FXR1 extracted from brain by immunoprecipitation shows yellow-green birefringence after staining with Congo red.	thioflavin T	98-110	FMR1 autosomal homolog 1	Rattus norvegicus	15-19
31746886-4	2019	SDS-PAGE analysis supported by Thioflavin T measurement showed that the WPI fibril formation accompanied by hydrolysis limited the formation reaction rate; further analysis indicated that main impurities especially for alpha-lactalbumin may affect the intermolecular contacts among beta-lg.	thioflavin T	31-41	lactalbumin alpha	Homo sapiens	219-236
31561043-7	2019	Further, 49 also exhibited anti-Abeta aggregation activity in self- and AChE-induced thioflavin T assay, which was ascertained by morphological characterization by atomic force microscopy (AFM).	thioflavin T	85-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
31027853-3	2019	The corresponding recombinant tau proteins showed reduced microtubule assembly and increased aggregation by thioflavin S assay.	thioflavin T	108-120	microtubule associated protein tau	Homo sapiens	30-33
31580671-0	2019	Additional Thioflavin-T Binding Mode in Insulin Fibril Inner Core Region.	thioflavin T	11-21	insulin	Homo sapiens	40-47
31580415-7	2019	alpha-Synuclein inclusions were thioflavin-S-positive suggesting that the inclusions induced by alpha-synuclein preformed fibrils exhibited pathological properties similar to amyloid-like Lewy body pathology in Parkinson"s disease brains.	thioflavin T	32-44	alpha-synuclein	Macaca fascicularis	0-15
31580415-7	2019	alpha-Synuclein inclusions were thioflavin-S-positive suggesting that the inclusions induced by alpha-synuclein preformed fibrils exhibited pathological properties similar to amyloid-like Lewy body pathology in Parkinson"s disease brains.	thioflavin T	32-44	alpha-synuclein	Macaca fascicularis	96-111
31592638-8	2019	Protein aggregation studies using a residual enzymatic activity assay, circular dichroism, and a Thioflavin T assay revealed that the secondary structure of the lysozyme was retained even after harsh thermal treatment.	thioflavin T	97-109	lysozyme	Homo sapiens	161-169
31495783-5	2019	Using thioflavin T assays, circular dichroism spectroscopy, and transmission electron microscopy analyses, we found that beta2m efficiently forms amyloid fibrils even at neutral pH by heating with agitation at high-salt conditions.	thioflavin T	6-18	beta-2-microglobulin	Homo sapiens	121-127
31580671-4	2019	In this work, we examine the binding of ThT to insulin fibrils generated at pH 2.4 and reveal a possible inner core binding mode which is not accessible to the dye molecule after aggregation occurs.	thioflavin T	40-43	insulin	Homo sapiens	47-54
31484760-4	2019	In addition to the increase in the number and size, we discovered an age-dependent acquisition of thioflavin S+, amyloid-like adhesive properties of mutant Htt aggregates and a concomitant progressive clustering of aggregates with mitochondria and synaptic proteins, indicating that the amyloid-like adhesive property underlies the neurotoxicity of mutant Htt aggregation.	thioflavin T	98-111	huntingtin	Drosophila melanogaster	156-159
31432820-0	2019	A zirconium-based metal-organic framework sensitized by thioflavin-T for sensitive photoelectrochemical detection of C-reactive protein.	thioflavin T	56-68	C-reactive protein	Homo sapiens	117-135
31432820-1	2019	Herein, a novel photoelectrochemical (PEC) assay was developed for the sensitive detection of C-reactive protein (CRP) based on a zirconium-based metal-organic framework (PCN-777) as the photoelectric material and thioflavin-T (Th-T) as the effective signal sensitizer coupled with rolling circle amplification (RCA).	thioflavin T	214-226	C-reactive protein	Homo sapiens	94-112
31432820-1	2019	Herein, a novel photoelectrochemical (PEC) assay was developed for the sensitive detection of C-reactive protein (CRP) based on a zirconium-based metal-organic framework (PCN-777) as the photoelectric material and thioflavin-T (Th-T) as the effective signal sensitizer coupled with rolling circle amplification (RCA).	thioflavin T	214-226	C-reactive protein	Homo sapiens	114-117
31432820-1	2019	Herein, a novel photoelectrochemical (PEC) assay was developed for the sensitive detection of C-reactive protein (CRP) based on a zirconium-based metal-organic framework (PCN-777) as the photoelectric material and thioflavin-T (Th-T) as the effective signal sensitizer coupled with rolling circle amplification (RCA).	thioflavin T	228-232	C-reactive protein	Homo sapiens	94-112
31432820-1	2019	Herein, a novel photoelectrochemical (PEC) assay was developed for the sensitive detection of C-reactive protein (CRP) based on a zirconium-based metal-organic framework (PCN-777) as the photoelectric material and thioflavin-T (Th-T) as the effective signal sensitizer coupled with rolling circle amplification (RCA).	thioflavin T	228-232	C-reactive protein	Homo sapiens	114-117
31424918-3	2019	Here, we find N-terminally acetylated alphaSyn (Ac-alphaSyn) aggregates more slowly than non-acetylated alphaSyn (NH3-alphaSyn) with significantly reduced sensitivity to thioflavin T (ThT).	thioflavin T	170-182	synuclein alpha	Homo sapiens	38-46
31424918-3	2019	Here, we find N-terminally acetylated alphaSyn (Ac-alphaSyn) aggregates more slowly than non-acetylated alphaSyn (NH3-alphaSyn) with significantly reduced sensitivity to thioflavin T (ThT).	thioflavin T	170-182	synuclein alpha	Homo sapiens	51-59
31424918-3	2019	Here, we find N-terminally acetylated alphaSyn (Ac-alphaSyn) aggregates more slowly than non-acetylated alphaSyn (NH3-alphaSyn) with significantly reduced sensitivity to thioflavin T (ThT).	thioflavin T	184-187	synuclein alpha	Homo sapiens	38-46
31424918-3	2019	Here, we find N-terminally acetylated alphaSyn (Ac-alphaSyn) aggregates more slowly than non-acetylated alphaSyn (NH3-alphaSyn) with significantly reduced sensitivity to thioflavin T (ThT).	thioflavin T	184-187	synuclein alpha	Homo sapiens	51-59
31424918-5	2019	Interestingly, the low-ThT Ac-alphaSyn fibrils seed both acetylated and non-acetylated alphaSyn and faithfully propagate the low-ThT character through several generations, indicating a stable fibril polymorph.	thioflavin T	23-26	synuclein alpha	Homo sapiens	30-38
31424918-5	2019	Interestingly, the low-ThT Ac-alphaSyn fibrils seed both acetylated and non-acetylated alphaSyn and faithfully propagate the low-ThT character through several generations, indicating a stable fibril polymorph.	thioflavin T	23-26	synuclein alpha	Homo sapiens	87-95
31424918-5	2019	Interestingly, the low-ThT Ac-alphaSyn fibrils seed both acetylated and non-acetylated alphaSyn and faithfully propagate the low-ThT character through several generations, indicating a stable fibril polymorph.	thioflavin T	129-132	synuclein alpha	Homo sapiens	30-38
31324836-8	2019	Interestingly, SEN-causing mutations also favor the tendency of KCTD1 to adopt structural states that are characterized by the ability to bind the beta-amyloid fluorescent dye thioflavin T.	thioflavin T	176-188	potassium channel tetramerization domain containing 1	Homo sapiens	64-69
31288978-5	2019	Meanwhile, compound 42 also inhibited AChE-induced Abeta aggregation (39.5-66.9%) in thioflavin T assay.	thioflavin T	85-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
31102680-9	2019	Thioflavin T fluorescence suggests GRASP55 intermediate can be aggregates/fibrils.	thioflavin T	0-12	golgi reassembly stacking protein 2	Homo sapiens	35-42
31390360-6	2019	We show that CREST is toxic in yeast and forms nuclear and occasionally cytoplasmic foci that stain with Thioflavin-T, a dye indicative of amyloid-like protein.	thioflavin T	105-117	SS18L1 subunit of BAF chromatin remodeling complex	Homo sapiens	13-18
31209546-0	2019	A label-free fluorescence method based on terminal deoxynucleotidyl transferase and thioflavin T for detecting prostate-specific antigen.	thioflavin T	84-96	kallikrein related peptidase 3	Homo sapiens	111-136
31209546-3	2019	In this work, a label-free fluorescent method was developed based on terminal deoxynucleotidyl transferase (TdT) and G-quadruplex-thioflavin T complex for detecting PSA.	thioflavin T	130-142	kallikrein related peptidase 3	Homo sapiens	165-168
31695369-2	2019	Methods: In this paper, the inhibitory effect of cerium oxide (CeO2) NPs against alpha-synuclein (alpha-syn) amyloid formation was explored by different methods such as Thioflavin T (ThT) and 8-anilinonaphthalene-1-sulfonic acid (ANS) fluorescence spectroscopy, Congo red adsorption assay, circular dichroism (CD) spectroscopy, transmission electron microscopy (TEM), and bioinformatical approaches.	thioflavin T	183-186	synuclein alpha	Homo sapiens	81-96
31695369-2	2019	Methods: In this paper, the inhibitory effect of cerium oxide (CeO2) NPs against alpha-synuclein (alpha-syn) amyloid formation was explored by different methods such as Thioflavin T (ThT) and 8-anilinonaphthalene-1-sulfonic acid (ANS) fluorescence spectroscopy, Congo red adsorption assay, circular dichroism (CD) spectroscopy, transmission electron microscopy (TEM), and bioinformatical approaches.	thioflavin T	183-186	synuclein alpha	Homo sapiens	81-90
31417892-7	2019	The insulin molecular structure and fibril morphology have been shown to be modified at different stages of its fibrillation, which has been proved by comparative analysis of the data obtained using circular dichroism, dynamic light scattering, amyloid-specific thioflavin T (ThT) assay, transmission electron microscopy, and high-speed atomic force microscopy.	thioflavin T	262-274	insulin	Homo sapiens	4-11
31417892-7	2019	The insulin molecular structure and fibril morphology have been shown to be modified at different stages of its fibrillation, which has been proved by comparative analysis of the data obtained using circular dichroism, dynamic light scattering, amyloid-specific thioflavin T (ThT) assay, transmission electron microscopy, and high-speed atomic force microscopy.	thioflavin T	276-279	insulin	Homo sapiens	4-11
31009195-2	2019	Insoluble senile plaques of Abeta in brain tissues are commonly stained with thioflavin and congo red dyes and observed through microscopy, while those in living patient brains are detected via radioisotope-labeled fluorescence chemicals for positron emission tomography.	thioflavin T	77-87	amyloid beta precursor protein	Homo sapiens	28-33
31180362-6	2019	Transduced cultures produce tau aggregates that stain positively for thioflavin and display markers of neurotoxicity, such as decreased axonal length and increased lysosomal volume.	thioflavin T	69-79	microtubule associated protein tau	Homo sapiens	28-31
31109117-7	2019	Results of the Thioflavin T Kinetic (ThT) and TEM assay showed that Abeta aggregate formation was inhibited by each tea type.	thioflavin T	15-27	amyloid beta precursor protein	Rattus norvegicus	68-73
30648297-9	2019	IL-1beta exposure-induced beta-cell stress after 4 H, decreased insulin levels, and increased thioflavin binding were noted.	thioflavin T	94-104	interleukin 1 beta	Rattus norvegicus	0-8
31034772-4	2019	We characterized the binding region of HSA on alpha-syn by high-field solution NMR spectroscopy and the effect of HSA on alpha-syn aggregation by thioflavin-T (ThT) fluorescence under both low-ionic-strength and physiological conditions at the albumin concentration in serum and CSF.	thioflavin T	146-158	synuclein alpha	Homo sapiens	121-130
31034772-4	2019	We characterized the binding region of HSA on alpha-syn by high-field solution NMR spectroscopy and the effect of HSA on alpha-syn aggregation by thioflavin-T (ThT) fluorescence under both low-ionic-strength and physiological conditions at the albumin concentration in serum and CSF.	thioflavin T	160-163	synuclein alpha	Homo sapiens	121-130
30703662-0	2019	Spectroscopic studies of Thioflavin-T binding to c-Myc G-quadruplex DNA.	thioflavin T	25-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
30703662-3	2019	In this report, we provide a detailed account of Thioflavin T (ThT) interacting with a promoter gene (c-Myc) which has relevance in several types of human cancers.	thioflavin T	49-61	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
30703662-3	2019	In this report, we provide a detailed account of Thioflavin T (ThT) interacting with a promoter gene (c-Myc) which has relevance in several types of human cancers.	thioflavin T	63-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
30703662-4	2019	Using a variety of spectroscopic techniques, we have shown that the binding of ThT is selective to c-Myc G-quadruplex only, having poor interactions with the duplex DNA sequences.	thioflavin T	79-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	99-104
30703662-6	2019	Fluorescence studies showed that the binding of ThT to c-Myc G-quadruplex results in a large increase in the fluorescence emission spectrum of c-Myc G-quadruplex while the same to duplex DNAs was much poor.	thioflavin T	48-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-60
30703662-6	2019	Fluorescence studies showed that the binding of ThT to c-Myc G-quadruplex results in a large increase in the fluorescence emission spectrum of c-Myc G-quadruplex while the same to duplex DNAs was much poor.	thioflavin T	48-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-148
30703662-7	2019	Binding of ThT to c-Myc G-quadruplex results in thermal stabilization of the quadruplex DNA by up to 7.4  C and Job plot experiments demonstrated the presence of 1:1 and 2:1 ligand to quadruplex complexes.	thioflavin T	11-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
30771602-2	2019	Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method.	thioflavin T	138-150	microtubule associated protein tau	Homo sapiens	114-117
30784883-5	2019	Meanwhile, both these compounds inhibited self- and AChE-induced Abeta aggregation in thioflavin T assay, which was also re-affirmed by morphological characterization of Abeta aggregates using atomic force microscopy (AFM).	thioflavin T	86-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
30784883-5	2019	Meanwhile, both these compounds inhibited self- and AChE-induced Abeta aggregation in thioflavin T assay, which was also re-affirmed by morphological characterization of Abeta aggregates using atomic force microscopy (AFM).	thioflavin T	86-98	amyloid beta precursor protein	Homo sapiens	65-70
30838043-7	2019	The effectiveness of FLPNF on inhibiting hIAPP amyloid aggregation was tested by Thioflavin T (ThT) staining.	thioflavin T	81-93	islet amyloid polypeptide	Homo sapiens	41-46
30714272-4	2019	Under in vitro conditions, PG-4 formed visible aggregates and displayed the hallmark properties of typical amyloids such as enhanced binding of Congo red, increased fluorescence with Thioflavin-T, and fibrillar morphology under transmission electron microscopy.	thioflavin T	183-195	protegrin-4	Sus scrofa	27-31
30842997-6	2019	Importantly, we find that ThT extends lifespan of aex-3/T337 worms as it does with control N2 animals, showing both strains similar locomotion features under this treatment.	thioflavin T	26-29	MAP kinase-activating death domain protein	Caenorhabditis elegans	50-55
30312115-4	2019	Our research demonstrates that amyloid deposition existed in hIAPP-INS1 cell by the thioflavin S fluorescent staining, meanwhile the function of insulin secretion of hIAPP-INS1 cells was decreased significantly (p < 0.01).	thioflavin T	84-96	islet amyloid polypeptide	Homo sapiens	61-66
29663860-6	2019	Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket.	thioflavin T	148-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
29663860-6	2019	Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket.	thioflavin T	161-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
30794963-6	2019	Using a thioflavin-T assay, we observed that DBP-PLGA nanoparticles significantly inhibited Abeta aggregation in vitro.	thioflavin T	8-20	D site albumin promoter binding protein	Mus musculus	45-48
30968030-6	2019	The effect of the conjugate molecules on alpha-Syn aggregation in vitro was monitored using Thioflavin T fluorescence assay, circular dichroism, transmission electron microscopy, and Congo red birefringence assay.	thioflavin T	92-104	synuclein alpha	Homo sapiens	41-50
30893771-9	2019	The aortas of IGF-II/LDLR-/-ApoB100/100 mice showed large thioflavin-S-positive atherosclerotic plaques containing ox-LDL and macrophages.	thioflavin T	58-70	insulin-like growth factor 2	Mus musculus	14-20
30893771-9	2019	The aortas of IGF-II/LDLR-/-ApoB100/100 mice showed large thioflavin-S-positive atherosclerotic plaques containing ox-LDL and macrophages.	thioflavin T	58-70	low density lipoprotein receptor	Mus musculus	21-25
30893771-9	2019	The aortas of IGF-II/LDLR-/-ApoB100/100 mice showed large thioflavin-S-positive atherosclerotic plaques containing ox-LDL and macrophages.	thioflavin T	58-70	apolipoprotein B	Mus musculus	28-35
30684867-3	2019	Thioflavin-T assay indicated trihydroxy chalcones inhibited Abeta aggregation better.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	60-65
32255010-6	2019	Using an average particle size of 6.6 nm and increasing the concentration of the SiNPs to 5.0 mug mL-1, the Thioflavin T (ThT) fluorescence intensity decreased significantly by 90%, with an increased lag time of 76.8 h, compared to that of the control.	thioflavin T	108-120	L1 cell adhesion molecule	Mus musculus	98-102
32255010-6	2019	Using an average particle size of 6.6 nm and increasing the concentration of the SiNPs to 5.0 mug mL-1, the Thioflavin T (ThT) fluorescence intensity decreased significantly by 90%, with an increased lag time of 76.8 h, compared to that of the control.	thioflavin T	122-125	L1 cell adhesion molecule	Mus musculus	98-102
30530075-5	2019	The effect of the compounds on hIAPP amyloid fibril formation was evaluated with a thioflavin T (ThT) fluorescence-based kinetic assay.	thioflavin T	83-95	islet amyloid polypeptide	Homo sapiens	31-36
30530075-5	2019	The effect of the compounds on hIAPP amyloid fibril formation was evaluated with a thioflavin T (ThT) fluorescence-based kinetic assay.	thioflavin T	97-100	islet amyloid polypeptide	Homo sapiens	31-36
30572018-0	2019	A novel fluorometric method for inorganic pyrophosphatase detection based on G-quadruplex-thioflavin T.	thioflavin T	90-102	inorganic pyrophosphatase 1	Homo sapiens	32-57
30572018-1	2019	In this paper, we propose a fluorometric approach for the highly sensitive detection of inorganic pyrophosphatase (PPase) based on G-quadruplex-thioflavin T (ThT).	thioflavin T	144-156	inorganic pyrophosphatase 1	Homo sapiens	88-113
30572018-1	2019	In this paper, we propose a fluorometric approach for the highly sensitive detection of inorganic pyrophosphatase (PPase) based on G-quadruplex-thioflavin T (ThT).	thioflavin T	144-156	inorganic pyrophosphatase 1	Homo sapiens	115-120
30585717-3	2019	Thioflavin T kinetics fluorescence assays, dynamic light scattering measurements, far-UV circular dichroism, and transmission electron microscopy all indicate that M1-AuNP conjugates prevent IAPP fibrillation at M1:IAPP molar ratios of as low as 1:50, while free M1 is unable to prevent fibrillation at the same substoichiometric concentrations.	thioflavin T	0-12	islet amyloid polypeptide	Homo sapiens	191-195
30632567-2	2019	Here, we report chemical modifications of key amino acid residues of Abeta42 (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure.	thioflavin T	118-130	H1.3 linker histone, cluster member	Homo sapiens	83-86
30632567-2	2019	Here, we report chemical modifications of key amino acid residues of Abeta42 (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure.	thioflavin T	118-130	H1.4 linker histone, cluster member	Homo sapiens	88-91
30632567-2	2019	Here, we report chemical modifications of key amino acid residues of Abeta42 (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure.	thioflavin T	132-135	H1.3 linker histone, cluster member	Homo sapiens	83-86
30632567-2	2019	Here, we report chemical modifications of key amino acid residues of Abeta42 (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure.	thioflavin T	132-135	H1.4 linker histone, cluster member	Homo sapiens	88-91
30686993-7	2018	Co-immunofluorescence showed that the alpha-synuclein-immunoreactive aggregates are both thioflavin S and ubiquitin positive.	thioflavin T	89-101	synuclein alpha	Rattus norvegicus	38-53
30278239-3	2019	Here, the effects of DNA tetrahedrons on the formation of alpha-syn amyloid fibrils were investigated using various biochemical and biophysical methods such as thioflavin T fluorescence assay, atomic force microscopy, light scattering, transmission electron microscopy, and cell-based cytotoxicity assay.	thioflavin T	160-172	synuclein alpha	Homo sapiens	58-67
30315849-6	2019	The interaction leads insulin conformational rearrangement into amyloid-like fibril, which is studied using thioflavin T dye binding assay, circular dichroism spectroscopy and TEM, followed by cytotoxicity propensity using Alamar Blue dye reduction assay.	thioflavin T	108-120	insulin	Homo sapiens	22-29
30584141-6	2019	Our results showed that when pretreated with 3.0 mg/kg LPS, thioflavin S can be found in the brain bound to Abeta plaques in aged 5XFAD transgenic mice.	thioflavin T	60-72	amyloid beta (A4) precursor protein	Mus musculus	108-113
31642793-5	2019	RESULTS: The results showed that PrP 106-126 amyloid formation was inhibited by both LK and SP, as evidenced from Thioflavin T fluorescence assay.	thioflavin T	114-126	prion protein	Homo sapiens	33-36
30584141-9	2019	Our results suggest that the BBB in aged 5XFAD mouse model is susceptible to increased permeability mediated by LPS, allowing for improved delivery of the small molecule thioflavin S to target Abeta plaques and SPIO nanoparticles, which are significantly larger than antibodies used in clinical trials for immunotherapy of AD.	thioflavin T	170-182	amyloid beta (A4) precursor protein	Mus musculus	193-198
30309894-6	2018	Furthermore, all three apoE3 variants are aggregation-prone, as shown by dynamic light-scattering measurements and by their enhanced capacity to bind the amyloid probe thioflavin T.	thioflavin T	168-180	apolipoprotein E	Homo sapiens	23-28
30559642-0	2018	Tau"s Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal.	thioflavin T	69-79	EF-hand domain family member D2	Homo sapiens	30-35
30392756-5	2018	Thioflavin-S-staining confirmed the increased accumulation of aggregated NOTCH3 in VSMCR133C compared to VSMCWT.	thioflavin T	0-12	notch receptor 3	Homo sapiens	73-79
30285025-6	2018	Among the designed NDI-conjugates, l-dopa and dopamine derivatives (NLD and NDP, respectively) showed excellent aggregation modulation efficiency (inhibition and dissolution), as shown by the thioflavin T (ThT) binding assays, dot blot analysis and in cellulo studies.	thioflavin T	192-204	norrin cystine knot growth factor NDP	Homo sapiens	76-79
30285025-6	2018	Among the designed NDI-conjugates, l-dopa and dopamine derivatives (NLD and NDP, respectively) showed excellent aggregation modulation efficiency (inhibition and dissolution), as shown by the thioflavin T (ThT) binding assays, dot blot analysis and in cellulo studies.	thioflavin T	206-209	norrin cystine knot growth factor NDP	Homo sapiens	76-79
30385800-6	2018	We show that oxidative modification of Abeta impedes the ability for Abeta monomer to form fibres, as indicated by the amyloid specific dye Thioflavin T (ThT).	thioflavin T	140-152	amyloid beta precursor protein	Homo sapiens	39-44
30369028-3	2018	The thioflavin T assay and transmission electron microscopy show accelerated IAPP fibrillization through elimination of the nucleation phase and shortening of the elongation phase by the nanostructures.	thioflavin T	4-16	islet amyloid polypeptide	Homo sapiens	77-81
30350837-4	2018	Such interactions, probed in vitro by a thioflavin T kinetic assay, fluorescence quenching, circular dichroism spectroscopy, a cell viability assay and in silico by discrete molecular dynamics simulations, translated to a significant recovery of embryonic zebrafish from the damage elicited by IAPP in vivo, as indicated by improved hatching as well as alleviated reactive oxygen species production, abnormality and mortality of the organism.	thioflavin T	40-52	islet amyloid polypeptide	Danio rerio	294-298
30351325-5	2018	Thioflavin T fluorescence and circular dichroism spectroscopic analysis indicated that the nanobubbles induced the change of the peptide conformation to a beta-sheet structure.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	153-159
30385800-6	2018	We show that oxidative modification of Abeta impedes the ability for Abeta monomer to form fibres, as indicated by the amyloid specific dye Thioflavin T (ThT).	thioflavin T	140-152	amyloid beta precursor protein	Homo sapiens	69-74
30385800-6	2018	We show that oxidative modification of Abeta impedes the ability for Abeta monomer to form fibres, as indicated by the amyloid specific dye Thioflavin T (ThT).	thioflavin T	154-157	amyloid beta precursor protein	Homo sapiens	39-44
30385800-6	2018	We show that oxidative modification of Abeta impedes the ability for Abeta monomer to form fibres, as indicated by the amyloid specific dye Thioflavin T (ThT).	thioflavin T	154-157	amyloid beta precursor protein	Homo sapiens	69-74
30287796-6	2018	Aggregation curves measured by the standard thioflavin-T (ThT) fluorescence assay are shown to reflect the relative composition of protein monomers and soluble oligomers measured by nuclear magnetic resonance (NMR) for human insulin, and by dynamic light scattering (DLS) for ataxin-3.	thioflavin T	58-61	insulin	Homo sapiens	225-232
30287796-6	2018	Aggregation curves measured by the standard thioflavin-T (ThT) fluorescence assay are shown to reflect the relative composition of protein monomers and soluble oligomers measured by nuclear magnetic resonance (NMR) for human insulin, and by dynamic light scattering (DLS) for ataxin-3.	thioflavin T	58-61	ataxin 3	Homo sapiens	276-284
29372531-5	2018	Here, we report the amyloidogenesis of murine amylin, which showed lower responsivity to the fluorescent probe thioflavin T compared to human amylin, but presented highly organized fibrilar amyloid material.	thioflavin T	111-123	islet amyloid polypeptide	Mus musculus	46-52
30269782-7	2018	With a POPG:PrP molar ratio of 30:1, the ThT fluorescence of MoPrP was found to be lower than that of ChPrP, however, the POPG-induced MoPrP had higher beta-sheet content and was more proteinase K-resistant than POPG-induced ChPrP.	thioflavin T	41-44	prion protein	Mus musculus	12-15
30289953-4	2018	Here, we show that the SOD1 polypeptides undergo hydrogelation accompanied by the formation of thioflavin T-positive fibrils at pH 3.0 and 4.0, but not at pH 5.0 where precipitates are formed.	thioflavin T	95-107	superoxide dismutase 1	Homo sapiens	23-27
30356861-12	2018	4) phosphorylated alpha-syn, at Ser-129 (pSer129), was found to be increased in hm-alpha-syn injected animals in comparison to controls that overexpressed GFP alone, which was also found in the most of LB stained by the thioflavine S (ThS) in the SN field.	thioflavin T	220-233	synuclein alpha	Rattus norvegicus	18-27
30356861-12	2018	4) phosphorylated alpha-syn, at Ser-129 (pSer129), was found to be increased in hm-alpha-syn injected animals in comparison to controls that overexpressed GFP alone, which was also found in the most of LB stained by the thioflavine S (ThS) in the SN field.	thioflavin T	235-238	synuclein alpha	Rattus norvegicus	18-27
30077972-5	2018	Using thioflavin fluorescence, CD, and light scattering analysis along with atomic force microscopy imaging, we found that the temperature-dependent aggregation of beta2m markedly depends on NaCl concentration.	thioflavin T	6-16	beta-2-microglobulin	Homo sapiens	164-170
30223436-0	2018	Structural Features of Amyloid Fibrils Formed from the Full-Length and Truncated Forms of Beta-2-Microglobulin Probed by Fluorescent Dye Thioflavin T.	thioflavin T	137-149	beta-2-microglobulin	Homo sapiens	90-110
30223436-5	2018	Spectroscopic analysis of the obtained samples allowed us to detect one binding mode (type) of ThT interaction with all the studied variants of beta2M amyloid fibrils with affinity ~104 M-1.	thioflavin T	95-98	beta-2-microglobulin	Homo sapiens	144-150
30223436-8	2018	The observed differences in the ThT-beta2M fibrils binding parameters and characteristics of the bound dye allowed to prove not only the difference of the DeltaN10beta2m fibrils from other beta2M fibrils (that can be detected visually, for example, by transmission electron microscopy (TEM), but also the differences between beta2m and DeltaN6beta2m fibrils (that can not be unequivocally confirmed by other approaches).	thioflavin T	32-35	beta-2-microglobulin	Homo sapiens	36-42
30223436-8	2018	The observed differences in the ThT-beta2M fibrils binding parameters and characteristics of the bound dye allowed to prove not only the difference of the DeltaN10beta2m fibrils from other beta2M fibrils (that can be detected visually, for example, by transmission electron microscopy (TEM), but also the differences between beta2m and DeltaN6beta2m fibrils (that can not be unequivocally confirmed by other approaches).	thioflavin T	32-35	beta-2-microglobulin	Homo sapiens	189-195
30223436-8	2018	The observed differences in the ThT-beta2M fibrils binding parameters and characteristics of the bound dye allowed to prove not only the difference of the DeltaN10beta2m fibrils from other beta2M fibrils (that can be detected visually, for example, by transmission electron microscopy (TEM), but also the differences between beta2m and DeltaN6beta2m fibrils (that can not be unequivocally confirmed by other approaches).	thioflavin T	32-35	beta-2-microglobulin	Homo sapiens	163-169
30012864-4	2018	Computer-based predictions of secondary structure, mutational analyses, and fluorescent titration with the beta-sheet dye thioflavin T suggest that eIF4G1(S1093) modulates a 4-stranded beta-sheet composed of antiparallel beta-hairpins formed by the autoinhibitory elements in eIF4G1"s unstructured regions.	thioflavin T	122-134	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	148-154
29964137-11	2018	Studies of in vitro Thioflavin S Tau-aggregation assays show half-maximal inhibitory activities (IC50 values) of BB17/conjugates in the low micro-molar range.	thioflavin T	20-32	B.burgdorferi-associated arthritis 17	Mus musculus	113-117
30486688-0	2018	Polymorph-specific distribution of binding sites determines thioflavin-T fluorescence intensity in alpha-synuclein fibrils.	thioflavin T	60-72	synuclein alpha	Homo sapiens	99-114
29366673-5	2018	Using a thioflavin T kinetic assay, transmission electron microscopy and a hemolysis assay here we show that human serum albumin, the most abundant protein in the plasma, impeded the fibrillization and mitigated membrane damage of both IAPP and alphaS.	thioflavin T	8-20	albumin	Homo sapiens	115-128
29859874-3	2018	Thioflavin-T fluorescence assay demonstrated that at physiological concentrations, NAA substantially inhibited the initiation of Abeta fibril formation.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	129-134
29733334-8	2018	Nonetheless, lowering the expression of the human tau transgene was sufficient to equally ameliorate thioflavin-S positive tangles and prevent neuronal loss equally well in both the APP/PS1 x rTg4510 mice and the rTg4510 cohort.	thioflavin T	101-113	microtubule associated protein tau	Homo sapiens	50-53
30142878-0	2018	Investigation of alpha-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T.	thioflavin T	77-89	synuclein alpha	Homo sapiens	17-32
30142878-1	2018	In this work, alpha-synuclein amyloid fibrils-the formation of which is a biomarker of Parkinson"s disease-were investigated using the fluorescent probe thioflavin T (ThT).	thioflavin T	153-165	synuclein alpha	Homo sapiens	14-29
30142878-1	2018	In this work, alpha-synuclein amyloid fibrils-the formation of which is a biomarker of Parkinson"s disease-were investigated using the fluorescent probe thioflavin T (ThT).	thioflavin T	167-170	synuclein alpha	Homo sapiens	14-29
30142878-4	2018	For the determination of ThT-alpha-synuclein amyloid fibril binding parameters, the sample and reference solutions were prepared using equilibrium microdialysis.	thioflavin T	25-28	synuclein alpha	Homo sapiens	29-44
30142878-8	2018	The obtained differences in the ThT binding parameters to the amyloid fibrils formed from alpha-synuclein and other amyloidogenic proteins, as well as in the photophysical characteristics of the bound dye, confirmed the hypothesis of amyloid fibril polymorphism.	thioflavin T	32-35	synuclein alpha	Homo sapiens	90-105
30024736-3	2018	Here we report that the concentration-dependent capability of DNAJB6 to suppress fibril formation in thioflavin T fluorescence assays decreases progressively with an increasing number of S/T substitutions, with an almost complete loss of suppression when 18 S/T residues are substituted.	thioflavin T	101-113	DnaJ heat shock protein family (Hsp40) member B6	Homo sapiens	62-68
29906302-5	2018	The high binding affinities and desirable photophysical properties of these complexes render them potential alternatives to established fluorescent Abeta probes such as thioflavin T.	thioflavin T	169-181	amyloid beta precursor protein	Homo sapiens	148-153
29727655-3	2018	However, near UV experiments, Dynamic Light Scattering, Thioflavin-T fluorescence measurements and Atomic Force Microscopy revealed that the kinetics from native-to-fibrillar state of insulin is hampered only in the presence of (-)-epigallocatechin-3-gallate.	thioflavin T	56-68	insulin	Homo sapiens	184-191
30069495-0	2018	alpha-Synuclein Aggregation Monitored by Thioflavin T Fluorescence Assay.	thioflavin T	41-53	synuclein alpha	Homo sapiens	0-15
30097010-7	2018	CONCLUSIONS: The fluorescence of functionalized NDs is more stable than that of fluorescent markers commonly used to stain Abeta aggregates such as Thioflavin T.	thioflavin T	148-160	amyloid beta (A4) precursor protein	Mus musculus	123-128
29853641-8	2018	We show that the Cdc19 aggregates share several structural features with pathological amyloids formed by human insulin and the Alzheimer"s disease-associated Abeta42 peptide, particularly secondary beta-sheet structure, thermodynamic stability, and staining by the thioflavin T dye.	thioflavin T	265-277	minichromosome maintenance complex component 2	Homo sapiens	17-22
29652131-0	2018	Thioflavin T Interaction with Acetylcholinesterase: New Evidence of 1:1 Binding Stoichiometry Obtained with Samples Prepared by Equilibrium Microdialysis.	thioflavin T	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
29652131-1	2018	The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE).	thioflavin T	69-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-119
29652131-1	2018	The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE).	thioflavin T	69-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
29652131-1	2018	The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE).	thioflavin T	83-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-119
29652131-1	2018	The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE).	thioflavin T	83-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
29652131-3	2018	Despite the extended and active investigation of ThT-AChE binding, there is still no common view on the stoichiometry of this interaction.	thioflavin T	49-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
29652131-4	2018	In particular, there is a hypothesis explaining the spectral properties of bound to AChE dye and high quantum yield of its fluorescence by formation of dimers or excimers of ThT.	thioflavin T	174-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
29652131-5	2018	In order to confirm or deny this hypothesis, we proposed a new experimental approach for examination of ThT-AChE interaction based on spectroscopic investigation of samples prepared by equilibrium microdialysis.	thioflavin T	104-107	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
29652131-6	2018	This approach allowed us to prove 1/1 ThT/AChE binding stoichiometry.	thioflavin T	38-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-46
29652131-7	2018	The increase of ThT fluorescence quantum yield and lifetime accompanying its binding to AChE can be explained by the molecular rotor nature of this dye.	thioflavin T	16-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-92
29652131-8	2018	Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE.	thioflavin T	70-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
29652131-8	2018	Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE.	thioflavin T	70-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-203
29652131-8	2018	Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE.	thioflavin T	166-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
29652131-9	2018	The model of ThT localization in the active site of AChE was proposed by using molecular docking simulations.	thioflavin T	13-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
29652131-10	2018	These results also allowed us to suggest the key role of aromatic residues in ThT-AChE interaction, as observed for some amyloid fibrils.	thioflavin T	78-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86
30079347-4	2018	The thioflavin-S staining and Western blot results (Abeta1-42 monomer/oligomer, APP, ADAM10, SAPPalpha, and PreP) showed that LIG reduced Abeta levels in the brain of APP/PS1 mice.	thioflavin T	4-16	ubiquitin-conjugating enzyme E2K	Mus musculus	126-129
29481950-8	2018	Increased ThT fluorescence and CR absorbance of 10mM MG incubated HSA suggests that glycated HSA results in the formation of aggregates of HSA.	thioflavin T	10-13	albumin	Homo sapiens	93-96
29481950-8	2018	Increased ThT fluorescence and CR absorbance of 10mM MG incubated HSA suggests that glycated HSA results in the formation of aggregates of HSA.	thioflavin T	10-13	albumin	Homo sapiens	93-96
29955078-5	2018	Surprisingly, immunocytochemical analysis of cortical levels of thioflavin S- and Abeta-reactive plaques showed that APP mice with a partial or complete lack of 7B2 expression exhibited a significantly lower number and burden of thioflavin S-reactive, as well as Abeta-immunoreactive, plaques.	thioflavin T	229-239	secretogranin V	Mus musculus	161-164
29760185-7	2018	In the presence of preformed profilin-1 aggregates, the PF state, unlike the unfolded and folded states, could interact with these aggregates via nonspecific hydrophobic interactions and also increase thioflavin-T fluorescence, revealing its amyloidogenic potential.	thioflavin T	201-213	profilin 1	Homo sapiens	29-39
29402077-7	2018	When applied to a blind, focused library of 17 Hsp90 inhibitors, our miniaturized single-read in vitro thioflavin T -based kinetics aggregation assay exclusively identified compounds that target the chaperone N-terminal nucleotide binding site.	thioflavin T	103-115	heat shock protein 90 alpha family class A member 1	Homo sapiens	47-52
29649360-3	2018	Under semiquiescent conditions (within a 96 well microplate, without a gyrating bead), the aggregation of apo-SOD1 into thioflavin-T-positive (ThT(+)) amyloid fibrils did not occur over 120 h in the absence of liposomal surfaces.	thioflavin T	120-132	superoxide dismutase 1	Homo sapiens	110-114
29378116-4	2018	Here, we apply all-atom discrete molecular dynamics simulations to investigate possible molecular mechanisms for the accelerated coaggregation of IAPP and Abeta42 comparing to Abeta42 aggregation alone, which was confirmed by the complementary thioflavin-T fluorescence assay.	thioflavin T	244-256	islet amyloid polypeptide	Homo sapiens	146-150
29381047-0	2018	Core Binding Site of a Thioflavin-T-Derived Imaging Probe on Amyloid beta Fibrils Predicted by Computational Methods.	thioflavin T	23-35	amyloid beta precursor protein	Homo sapiens	61-73
29381047-2	2018	In this study, we investigated the most accessible amyloid beta (Abeta) binding site of [123I]IMPY, a Thioflavin-T-derived SPECT probe, using experimental and computational methods.	thioflavin T	102-112	amyloid beta precursor protein	Homo sapiens	51-63
29381047-2	2018	In this study, we investigated the most accessible amyloid beta (Abeta) binding site of [123I]IMPY, a Thioflavin-T-derived SPECT probe, using experimental and computational methods.	thioflavin T	102-112	amyloid beta precursor protein	Homo sapiens	65-70
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	26-38	ATP binding cassette subfamily B member 1	Homo sapiens	200-203
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	26-38	ATP binding cassette subfamily B member 1	Homo sapiens	205-219
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	26-38	ATP binding cassette subfamily B member 1	Homo sapiens	221-226
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	40-43	ATP binding cassette subfamily B member 1	Homo sapiens	200-203
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	40-43	ATP binding cassette subfamily B member 1	Homo sapiens	205-219
30108983-5	2018	Herein, we postulate that thioflavin T (ThT), due to its physico-chemical attributes, such as moderate lipophilicity and protonated nitrogen, could very well be recognized as a transport substrate of Pgp (P-glycoprotein, ABCB1) thus restricting its permeation into the brain.	thioflavin T	40-43	ATP binding cassette subfamily B member 1	Homo sapiens	221-226
30108983-7	2018	While ThT penetrates KB-3-1 cells, it gets excluded from KB-8-5 cells, and also indicates LY335979-induced uptake in Pgp-expressing cells.	thioflavin T	6-9	ATP binding cassette subfamily B member 1	Homo sapiens	117-120
30108983-9	2018	These data show that uptake profiles of ThT have been modified by the expression of Pgp in these cells, and are inversely proportional to the expression of the transporter protein located on the plasma membrane of these cells.	thioflavin T	40-43	ATP binding cassette subfamily B member 1	Homo sapiens	84-87
30108983-10	2018	Combined data demonstrate that ThT is efficiently recognized by Pgp as its transport substrate.	thioflavin T	31-34	ATP binding cassette subfamily B member 1	Homo sapiens	64-67
29611693-4	2018	In the early nucleation stage of Abeta40 aggregation, while no fluorescence was detectable with traditional thioflavin T (ThT) assay, the prominent electrical signals probed by GM1-SLB/G-FET demonstrate that the G-FET detection is more sensitive than the ThT assay.	thioflavin T	255-258	intraflagellar transport 172	Homo sapiens	177-190
29472250-5	2018	We found that tau droplets become gel-like in minutes, and over days start to spontaneously form thioflavin-S-positive tau aggregates that are competent of seeding cellular tau aggregation.	thioflavin T	97-107	microtubule associated protein tau	Homo sapiens	14-17
29577153-4	2018	Thioflavin T fluorescence kinetics measurements revealed a stronger autocatalytic behaviour of IAPP and a weaker concentration dependence of fibrillization half-time t1/2, as compared to Abeta42.	thioflavin T	0-12	islet amyloid polypeptide	Homo sapiens	95-99
29472250-5	2018	We found that tau droplets become gel-like in minutes, and over days start to spontaneously form thioflavin-S-positive tau aggregates that are competent of seeding cellular tau aggregation.	thioflavin T	97-107	microtubule associated protein tau	Homo sapiens	119-122
29472250-5	2018	We found that tau droplets become gel-like in minutes, and over days start to spontaneously form thioflavin-S-positive tau aggregates that are competent of seeding cellular tau aggregation.	thioflavin T	97-107	microtubule associated protein tau	Homo sapiens	119-122
29409811-6	2018	Using transmission electron microscopy and thioflavin-T fluorescent dye, we have shown that albumin traps Abeta as oligomers, 9 nm in diameter.	thioflavin T	43-55	amyloid beta precursor protein	Homo sapiens	106-111
29615769-3	2018	This designed aptamer combined particular sequence for the c-Met on the cell surface and poly-G-quadruplexes structures that allow a rapid and amplified fluorescent readout upon the binding of thioflavin T (ThT).	thioflavin T	193-205	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	59-64
29615769-3	2018	This designed aptamer combined particular sequence for the c-Met on the cell surface and poly-G-quadruplexes structures that allow a rapid and amplified fluorescent readout upon the binding of thioflavin T (ThT).	thioflavin T	207-210	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	59-64
29615769-5	2018	This unique c-Met targeting aptamer enabled simultaneous monitoring of c-Met on the cell surface with ThT and photodynamic killing of these lung cancer cells with TMPyP4.	thioflavin T	102-105	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	12-17
29615769-5	2018	This unique c-Met targeting aptamer enabled simultaneous monitoring of c-Met on the cell surface with ThT and photodynamic killing of these lung cancer cells with TMPyP4.	thioflavin T	102-105	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	71-76
29523142-4	2018	METHODS: The fibril form of human IAPP (hIAPP) was tested using thioflavin-T fluorescence assay and transmission electron microscope technology after incubated with palmitate for 5 h at 25  C. The cytotoxicity of fibril hIAPP was evaluated in INS-1 cells through analyzing the leakage of cell membrane and cell apoptosis.	thioflavin T	64-76	islet amyloid polypeptide	Homo sapiens	34-38
29160692-5	2018	Initially, S100A9 fibrils were morphologically verified by atomic force microscopy and Thioflavin T assay.	thioflavin T	87-99	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	11-17
29523142-4	2018	METHODS: The fibril form of human IAPP (hIAPP) was tested using thioflavin-T fluorescence assay and transmission electron microscope technology after incubated with palmitate for 5 h at 25  C. The cytotoxicity of fibril hIAPP was evaluated in INS-1 cells through analyzing the leakage of cell membrane and cell apoptosis.	thioflavin T	64-76	islet amyloid polypeptide	Homo sapiens	40-45
29311134-5	2018	Ablation of Klk7 exacerbated the thioflavin S-positive Abeta pathology in AD model mice.	thioflavin T	33-43	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	Mus musculus	12-16
29311134-5	2018	Ablation of Klk7 exacerbated the thioflavin S-positive Abeta pathology in AD model mice.	thioflavin T	33-43	amyloid beta (A4) precursor protein	Mus musculus	55-60
29577851-9	2018	Aggregation of alpha-synuclein upon exposure to phospholipase A2-induced action on PC/PS liposomes was measured using thioflavin T fluorescence, SDS-PAGE, gel filtration chromatography, and transmission electron microscopy.	thioflavin T	118-130	synuclein alpha	Homo sapiens	15-30
29180135-6	2018	The human alpha-Syn accumulated during aging and formed PK-resistant, thioflavin-binding aggregates.	thioflavin T	70-80	synuclein alpha	Homo sapiens	10-19
29288051-6	2018	HS-induced increases in thioflavin T fluorescence for SAA (1-76) peptide and less significant increases for full-length SAA were observed.	thioflavin T	24-36	serum amyloid A1 cluster	Homo sapiens	54-57
29105391-10	2018	Importantly, Artemin was observed to effectively block the aggregation of both physiologic- and supraphysiologic TAU concentrations in a dose-dependent manner, as judged by ThT and CD spectroscopy analyses.	thioflavin T	173-176	artemin	Homo sapiens	13-20
29472606-5	2018	Thioflavin T fluorescent assays revealed that the inhibitory effect of CEHA was 69% and 55% higher than EHA and CHA, respectively, and cytotoxicity assays showed that the viability of SH-SY5Y cells incubated with Abeta and CEHA was 28% higher than that with Abeta and the mixture of EHA and CHA.	thioflavin T	0-12	amyloid beta precursor protein	Homo sapiens	213-218
28150569-2	2018	Catalase molecule aggregates at 50% TFE as evident by high thioflavin T fluorescence, shifted congo red absorbance, change in circular dichroism and soret spectra.	thioflavin T	59-71	catalase	Homo sapiens	0-8
29371591-5	2018	In addition, MIF alters the typical SOD1 amyloid aggregation pathway in vitro, and, instead, promotes the formation of disordered aggregates, as measured by Thioflavin T (ThT) assay and transmission electron microscopy (TEM) imaging.	thioflavin T	157-169	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	13-16
29371591-5	2018	In addition, MIF alters the typical SOD1 amyloid aggregation pathway in vitro, and, instead, promotes the formation of disordered aggregates, as measured by Thioflavin T (ThT) assay and transmission electron microscopy (TEM) imaging.	thioflavin T	171-174	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	13-16
28822269-0	2018	Correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-T fluorescence with their inhibition activity.	thioflavin T	80-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-156
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	44-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	44-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
28822269-2	2018	The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation.	thioflavin T	44-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-156
29577851-9	2018	Aggregation of alpha-synuclein upon exposure to phospholipase A2-induced action on PC/PS liposomes was measured using thioflavin T fluorescence, SDS-PAGE, gel filtration chromatography, and transmission electron microscopy.	thioflavin T	118-130	phospholipase A2 group IB	Homo sapiens	48-64
29186056-7	2017	Here, we extend this study by solving the crystal structures of human BChE in complex with five reversible ligands, namely, decamethonium, thioflavin T, propidium, huprine, and ethopropazine.	thioflavin T	139-151	butyrylcholinesterase	Homo sapiens	70-74
29171274-8	2017	We further demonstrate a unique application of the newly developed polymer for kinetics and structural characterization of the aggregation of human islet amyloid polypeptide (also known as amylin) within the lipid bilayer of the polymer nanodiscs using thioflavin-T-based fluorescence and circular dichroism experiments.	thioflavin T	253-265	islet amyloid polypeptide	Homo sapiens	189-195
28837764-3	2017	Thioflavin S (ThS) staining of amyloid colocalized with pathological phosphorylated Tau, suggesting that the peptide was able to seed endogenous wild-type Tau.	thioflavin T	0-12	microtubule associated protein tau	Homo sapiens	84-87
28837764-3	2017	Thioflavin S (ThS) staining of amyloid colocalized with pathological phosphorylated Tau, suggesting that the peptide was able to seed endogenous wild-type Tau.	thioflavin T	0-12	microtubule associated protein tau	Homo sapiens	155-158
28837764-3	2017	Thioflavin S (ThS) staining of amyloid colocalized with pathological phosphorylated Tau, suggesting that the peptide was able to seed endogenous wild-type Tau.	thioflavin T	14-17	microtubule associated protein tau	Homo sapiens	84-87
28837764-3	2017	Thioflavin S (ThS) staining of amyloid colocalized with pathological phosphorylated Tau, suggesting that the peptide was able to seed endogenous wild-type Tau.	thioflavin T	14-17	microtubule associated protein tau	Homo sapiens	155-158
29147551-4	2017	In this study, overlapping peptides were designed to target the "binding" region (RLANFLVHSS, residues 11-20) of human amylin, and their effects on amyloid fibril formation were determined by thioflavin-T assay.	thioflavin T	192-204	islet amyloid polypeptide	Homo sapiens	119-125
29246595-4	2017	In this study, amyloid-beta (Abeta) aggregates in platelet membranes from 65 patients with CAA and 66 healthy volunteers (controls) were confirmed through thioflavin T (ThT) assay and Western blot analysis.	thioflavin T	155-167	amyloid beta precursor protein	Homo sapiens	29-34
29246595-4	2017	In this study, amyloid-beta (Abeta) aggregates in platelet membranes from 65 patients with CAA and 66 healthy volunteers (controls) were confirmed through thioflavin T (ThT) assay and Western blot analysis.	thioflavin T	169-172	amyloid beta precursor protein	Homo sapiens	29-34
28986145-7	2017	Fibrillation of recombinantly expressed human betaB2-crystallin was performed in 10% (v/v) trifluoroethanol (TFE) solution (pH 2.0) at various temperatures, and its amyloid-like structure was confirmed using Thioflavin-T (ThT) assay, transmission electron microscopy (TEM), and X-ray fiber diffraction (XRFD) analysis.	thioflavin T	208-220	crystallin beta B2	Homo sapiens	46-63
28986145-7	2017	Fibrillation of recombinantly expressed human betaB2-crystallin was performed in 10% (v/v) trifluoroethanol (TFE) solution (pH 2.0) at various temperatures, and its amyloid-like structure was confirmed using Thioflavin-T (ThT) assay, transmission electron microscopy (TEM), and X-ray fiber diffraction (XRFD) analysis.	thioflavin T	222-225	crystallin beta B2	Homo sapiens	46-63
29594474-6	2017	Therefore, the change in fluorescence intensity of ThT is directly correlated to the concentration of Pb(II) and Hg(II).	thioflavin T	51-54	submaxillary gland androgen regulated protein 3B	Homo sapiens	102-108
29594474-10	2017	Graphical abstract A label free sensitive and selective "on-off" fluorescent assay for detection of Pb(II) and Hg(II) based on graphene oxide -DNAzyme complex with fluorogenic dye thioflavin T.	thioflavin T	180-192	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-106
28974578-5	2017	The effect of each acyl group on the rate of SOD1 fibril nucleation and elongation were quantified in vitro with thioflavin-T (ThT) fluorescence, and we performed 594 iterate aggregation assays to obtain statistically significant rates.	thioflavin T	113-125	superoxide dismutase 1, soluble	Mus musculus	45-49
28974578-5	2017	The effect of each acyl group on the rate of SOD1 fibril nucleation and elongation were quantified in vitro with thioflavin-T (ThT) fluorescence, and we performed 594 iterate aggregation assays to obtain statistically significant rates.	thioflavin T	127-130	superoxide dismutase 1, soluble	Mus musculus	45-49