PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21835921-5	2011	GT MG517 transfers glucosyl and galactosyl residues from UDP-Glc and UDP-Gal to dioleoylglycerol (DOG) acceptor to form the corresponding beta-glycosyl-DOG, which then acts as acceptor to give beta-diglycosyl-DOG products.	diolein	80-96	protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2	Canis lupus familiaris	0-2
26246845-5	2015	METHODS: Twenty individual phytochemicals and an internal proprietary botanical extract library were screened with a primary cell-free DGAT1 enzyme assay that contained dioleoyl glycerol and palmitoleoyl Coenzyme A as substrates plus human intestinal microsomes as the DGAT1 enzyme source.	diolein	169-186	diacylglycerol O-acyltransferase 1	Homo sapiens	135-140
25152299-4	2014	In this study, synthetic peptides corresponding to the predicted binding sites of DGAT1 enzyme were examined using synchrotron radiation circular dichroism spectroscopy, fluorescence emission and adsorption onto lipid monolayers to determine their interactions with substrates associated with triacylglyceride synthesis (oleoyl-CoA and dioleoylglycerol).	diolein	336-352	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
24779728-0	2014	Formation of highly structured cubic micellar lipid nanoparticles of soy phosphatidylcholine and glycerol dioleate and their degradation by triacylglycerol lipase.	diolein	97-114	lipase C, hepatic type	Homo sapiens	140-162
16426828-8	2006	The activity of PKC-epsilon, a novel-type PKC, was increased by adding DLPE, and PKC-gamma, a conventional-type PKC, was activated on the coaddition of diolein and DLPE, as shown by in vitro enzyme activity analysis.	diolein	152-159	protein kinase C, epsilon	Mus musculus	16-27
16905533-4	2006	gammaPKC directly associated with DGKgamma through its accessory domain (AD), depending on Ca2+ as well as phosphatidylserine/diolein in vitro.	diolein	126-133	diacylglycerol kinase gamma	Homo sapiens	34-42
19800417-4	2010	The fact that the ee% of 1,2-sn-diolein over 2,3-sn-diolein increased with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol.	diolein	227-243	lipase E, hormone sensitive type	Homo sapiens	114-117
19800417-6	2010	Among the various mammalian lipases tested so far, HSL is the only lipolytic carboxylester hydrolase found to have a pronounced stereospecificity for the sn-3 position of dioleoylglycerol.	diolein	171-187	lipase E, hormone sensitive type	Homo sapiens	51-54
18004883-2	2007	In comparison, a multiple lipid kinase, MuLK, shows much less stereospecificity, phosphorylating 1,2-dioleoylglycerol only approximately 2-3 times more rapidly than 2,3-dioleoylglycerol.	diolein	97-117	acylglycerol kinase	Homo sapiens	40-44
16426828-8	2006	The activity of PKC-epsilon, a novel-type PKC, was increased by adding DLPE, and PKC-gamma, a conventional-type PKC, was activated on the coaddition of diolein and DLPE, as shown by in vitro enzyme activity analysis.	diolein	152-159	protein kinase C, epsilon	Mus musculus	16-19
16426828-8	2006	The activity of PKC-epsilon, a novel-type PKC, was increased by adding DLPE, and PKC-gamma, a conventional-type PKC, was activated on the coaddition of diolein and DLPE, as shown by in vitro enzyme activity analysis.	diolein	152-159	protein kinase C, gamma	Mus musculus	81-90
16426828-8	2006	The activity of PKC-epsilon, a novel-type PKC, was increased by adding DLPE, and PKC-gamma, a conventional-type PKC, was activated on the coaddition of diolein and DLPE, as shown by in vitro enzyme activity analysis.	diolein	152-159	protein kinase C, epsilon	Mus musculus	42-45
15260473-5	2004	Recombinant human HSL also hydrolyzes insoluble medium- and long-chain acylglycerols such as trioctanoylglycerol, dioleoylglycerol, and olive oil, and can therefore be classified as a true lipase.	diolein	114-130	lipase E, hormone sensitive type	Homo sapiens	18-21
15364929-5	2004	Moreover, iPLA2epsilon, iPLA2zeta, and iPLA2eta also possess acylglycerol transacylase activity utilizing mono-olein as an acyl donor which, in the presence of mono-olein or diolein acceptors, results in the synthesis of diolein and triolein, respectively.	diolein	174-181	patatin like phospholipase domain containing 3	Homo sapiens	10-22
15364929-5	2004	Moreover, iPLA2epsilon, iPLA2zeta, and iPLA2eta also possess acylglycerol transacylase activity utilizing mono-olein as an acyl donor which, in the presence of mono-olein or diolein acceptors, results in the synthesis of diolein and triolein, respectively.	diolein	174-181	patatin like phospholipase domain containing 2	Homo sapiens	24-33
15364929-5	2004	Moreover, iPLA2epsilon, iPLA2zeta, and iPLA2eta also possess acylglycerol transacylase activity utilizing mono-olein as an acyl donor which, in the presence of mono-olein or diolein acceptors, results in the synthesis of diolein and triolein, respectively.	diolein	174-181	patatin like phospholipase domain containing 4	Homo sapiens	39-47
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	diolein	231-238	insulin receptor substrate 1	Canis lupus familiaris	111-116
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	diolein	231-238	protein kinase C beta	Canis lupus familiaris	174-177
9553124-7	1998	Addition of the cytoplasmic syndecan-4 peptide, but not equivalent syndecan-1 or syndecan-2 peptides, potentiated the partial activation of PKCalpha beta gamma by PIP2, resulting in activity greater than that observed with phosphatidylserine, diolein, and calcium.	diolein	243-250	syndecan 4	Homo sapiens	28-38
11871267-8	2001	Fats of elaiosome have a particular complex of fat acids, mainly 1,2-diolein, that attract ant workers.	diolein	65-76	solute carrier family 25 member 6	Homo sapiens	91-94
10811659-7	2000	Lipid binding studies revealed less R63A and R423G mutant CEL were bound to 1,2-diolein monolayer at saturation compared with wild type CEL.	diolein	76-87	carboxyl ester lipase	Rattus norvegicus	58-61
15357018-9	2004	When different molecular species of DAG were provided as substrates to the microsomal mixture, the RcDGAT showed a greater preference to catalyze the transfer of oleate from [14C]oleoyl-CoA to diricinolein than to diolein and dipalmitolein.	diolein	214-221	diacylglycerol O-acyltransferase 1	Ricinus communis	99-105
10090770-6	1999	The association of PKCalpha with membranes containing 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1, 2-dioleoylglycerol (DAG), determined from tryptophan to dansyl-PE resonance energy transfer (RET) measurements, was found to occur at relatively low Ca2+ levels (</=1 microM).	diolein	100-121	protein kinase C alpha	Homo sapiens	19-27
9553124-7	1998	Addition of the cytoplasmic syndecan-4 peptide, but not equivalent syndecan-1 or syndecan-2 peptides, potentiated the partial activation of PKCalpha beta gamma by PIP2, resulting in activity greater than that observed with phosphatidylserine, diolein, and calcium.	diolein	243-250	protein kinase C alpha	Homo sapiens	140-148
9235913-8	1997	In contrast, dioleoylglycerol, which accelerates the PLA2 activity, does not act as an acceptor in either the lysophospholipase or the PLA2 reaction, but can affect enzyme activities by altering substrate presentation.	diolein	13-29	phospholipase A2 group IB	Homo sapiens	53-57
9573621-1	1998	In the absence of DO, two additional 2D crystals of PKC delta are seen, suggesting that the presence of diolein (DO) alters the conformation of intact PKC at the lipid surface.	diolein	104-111	protein kinase C delta	Homo sapiens	52-61
9573621-1	1998	In the absence of DO, two additional 2D crystals of PKC delta are seen, suggesting that the presence of diolein (DO) alters the conformation of intact PKC at the lipid surface.	diolein	104-111	protein kinase C alpha	Homo sapiens	52-55
9573621-1	1998	In the absence of DO, two additional 2D crystals of PKC delta are seen, suggesting that the presence of diolein (DO) alters the conformation of intact PKC at the lipid surface.	diolein	113-115	protein kinase C delta	Homo sapiens	52-61
9573621-1	1998	In the absence of DO, two additional 2D crystals of PKC delta are seen, suggesting that the presence of diolein (DO) alters the conformation of intact PKC at the lipid surface.	diolein	113-115	protein kinase C alpha	Homo sapiens	52-55
8567673-8	1996	Trioleoylglycerol- and dioleoylglycerol-hydrolyzing activities of the purified enzyme and pancreatic lipase were inhibited by addition of intestinal mucosa extract.	diolein	23-39	pancreatic lipase	Rattus norvegicus	90-107
9117107-8	1997	Immunoblots with an antibody against classical PKCs and the activator profile for phosphatidylserine, diolein and Ca2+ revealed that the PKC from rat kidney, which did not bind to phenylsepharose, was most probably due to a proteolytically-generated, constitutively active PKC which is not under the control of a regulatory subunit.	diolein	102-109	protein kinase C, gamma	Rattus norvegicus	137-140
8781494-7	1996	The oleic acid-induced increase of PKC activity in cell lysates was similar in the presence and absence of Ca2+, phosphatidylserine, and diolein (maximum response, 360 +/- 4% versus 342 +/- 9% of control, P = NS).	diolein	137-144	proline rich transmembrane protein 2	Homo sapiens	35-38
7601150-6	1995	Using rabbit pancreatic lipase, we found that deoxycholate enhanced dioleoylglycerol hydrolysis to a higher degree than trioleoylglycerol hydrolysis.	diolein	68-84	pancreatic triacylglycerol lipase	Oryctolagus cuniculus	13-30
8654754-0	1995	The effect of dioleoylglycerol on cytosolic phospholipase A2 activity using a continuous fluorescence displacement assay.	diolein	14-30	phospholipase A2 group IVA	Homo sapiens	34-60
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	diolein	136-152	calmodulin 1	Homo sapiens	0-3
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	diolein	136-152	S100 calcium binding protein B	Homo sapiens	8-12
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	diolein	136-152	pyruvate kinase M1/2	Homo sapiens	27-30
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	diolein	136-152	myristoylated alanine rich protein kinase C substrate	Homo sapiens	60-66
24203271-6	1994	However, PKC activity stimulated by phospholipid, Ca(2+) ions and diolein was inhibited in a dose related fashion by all of these fatty acids.	diolein	66-73	proline rich transmembrane protein 2	Homo sapiens	9-12
8418861-0	1993	Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine.	diolein	54-61	proline rich transmembrane protein 2	Homo sapiens	27-43
8418861-5	1993	PKC bound either to PS alone or to PS and DG was enzymatically competent; however, the rate of phosphorylation was doubled in the presence of 1 mol % diolein.	diolein	150-157	proline rich transmembrane protein 2	Homo sapiens	0-3
1824257-3	1991	Basal, phosphatidylserine-independent, and diolein-independent phosphorylation of cytosolic substrates with molecular weights of 17, 52, 57, and 105 Kd were enhanced in FD/PMA cells grown in PMA as compared with FDC-P1 cells cultured in IL-3.	diolein	43-50	interleukin 3	Mus musculus	237-241
1903566-3	1991	Catalase (CT) suppressed the promoting effects of diolein by up to 70%.	diolein	50-57	catalase	Mus musculus	0-8
1909124-1	1991	Optimal phosphorylation of lipid-free apo A-1 occurs in the absence of calcium, phosphatidyl serine (PS), and diolein (DO).	diolein	110-117	apolipoprotein A1	Homo sapiens	38-45
1909124-1	1991	Optimal phosphorylation of lipid-free apo A-1 occurs in the absence of calcium, phosphatidyl serine (PS), and diolein (DO).	diolein	119-121	apolipoprotein A1	Homo sapiens	38-45
1909304-4	1991	Although synthetic 1,2-diglyceride (diolein) dose dependently stimulated endothelin-1 release, downregulation of protein kinase C after pretreatment with phorbol ester resulted in decreased effects to increase endothelin-1 release by the agonists.	diolein	36-43	endothelin 1	Bos taurus	73-85
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	diolein	48-55	protein kinase C, gamma	Rattus norvegicus	125-141
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	diolein	48-55	protein kinase C, gamma	Rattus norvegicus	143-146
1903566-3	1991	Catalase (CT) suppressed the promoting effects of diolein by up to 70%.	diolein	50-57	catalase	Mus musculus	10-12
2153114-5	1990	These enzymes both phosphorylate 1,2-dioleoyl glycerol at rates of 11.5 mumol/min/mg protein for DGK I and 5.2 mumol/min/mg protein for DGK IV.	diolein	33-54	diacylglycerol kinase, iota	Rattus norvegicus	97-108
1847919-6	1991	The activities of the CPT1 and EPT1 gene products were compared with respect to dioleoylglycerol dependence, CDP-aminoalcohol specificity, phospholipid activation, and inhibition by CMP.	diolein	80-96	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	22-26
1698459-5	1990	Phosphorylation of the exogenous substrate myelin basic protein by DEAE-resolved ovarian kinase showed the variant effector dependence, maximal in the presence of EGTA, phosphatidylserine and 1,2-diolein.	diolein	192-203	myelin basic protein	Homo sapiens	43-63
2254963-7	1990	Likewise phosphorylation of GFAP was also accentuated by calcium/phosphatidylserine/diolein and by exogenous cyclic AMP-dependent kinase in a cell free system.	diolein	84-91	glial fibrillary acidic protein	Homo sapiens	28-32
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	diolein	101-117	cut-like homeobox 1	Rattus norvegicus	177-180
2233125-0	1990	Ethanol and diolein stimulate PKC translocation in astroglial cells.	diolein	12-19	proline rich transmembrane protein 2	Homo sapiens	30-33
2233125-3	1990	When ethanol (25-200 mM) or diolein (3 microM) was applied to cells for 30 seconds, PKC activity was observed to decrease in the cytosol and increase in the membrane fraction of the cell while the whole cell activity remained unchanged.	diolein	28-35	proline rich transmembrane protein 2	Homo sapiens	84-87
2233125-5	1990	When ethanol (100 mM) and diolein (3 microM) were applied simultaneously, membrane-associated activity increased to become 3-5 times greater than when either PKC activator was applied alone.	diolein	26-33	proline rich transmembrane protein 2	Homo sapiens	158-161
2233125-6	1990	These changes in PKC activity parallel changes in taurine release observed when cells are exposed to ethanol and the PKC activator diolein.	diolein	131-138	proline rich transmembrane protein 2	Homo sapiens	17-20
2233125-6	1990	These changes in PKC activity parallel changes in taurine release observed when cells are exposed to ethanol and the PKC activator diolein.	diolein	131-138	proline rich transmembrane protein 2	Homo sapiens	117-120
2158087-2	1990	Diolein alone did not act on this enzyme but exerted a strong stimulatory action when associated with phosphatidylserine and Ca2+.	diolein	0-7	carbonic anhydrase 2	Homo sapiens	125-128
2153114-5	1990	These enzymes both phosphorylate 1,2-dioleoyl glycerol at rates of 11.5 mumol/min/mg protein for DGK I and 5.2 mumol/min/mg protein for DGK IV.	diolein	33-54	diacylglycerol kinase zeta	Rattus norvegicus	136-142
2537172-10	1989	Activation of cytosolic PKC by diolein, phosphatidylserine, and calcium caused phosphorylation of many cytosolic proteins, including those having apparent mol wt of 39K, 35K, 33K, 25K, 19K, and 16K.	diolein	31-38	protein kinase C, gamma	Rattus norvegicus	24-27
3355850-8	1988	Phospholipase A2-mediated hydrolysis of alkylarachidonoyl-GPC is increased 2-fold by albumin and is enhanced 5-fold if 1,2-dioleoylglycerol is incorporated into the substrate dispersion.	diolein	119-139	phospholipase A2 group IB	Homo sapiens	0-16
3229039-5	1988	When vinculin was the substrate, the Ka for Ca2+ was 4 microM and 0.8 microM in the absence and in the presence of diolein, indicating that the sensitivity to Ca2+ and the mechanism of the diolein activation can be influenced by the substrate.	diolein	115-122	vinculin	Bos taurus	5-13
3229039-5	1988	When vinculin was the substrate, the Ka for Ca2+ was 4 microM and 0.8 microM in the absence and in the presence of diolein, indicating that the sensitivity to Ca2+ and the mechanism of the diolein activation can be influenced by the substrate.	diolein	189-196	vinculin	Bos taurus	5-13
2833930-4	1988	The apparent Km values for CDP-ethanolamine were the same (0.26 mm) for endogenously generated dipalmitoylglycerol and dioleoylglycerol.	diolein	119-135	cut-like homeobox 1	Rattus norvegicus	27-30
3355850-8	1988	Phospholipase A2-mediated hydrolysis of alkylarachidonoyl-GPC is increased 2-fold by albumin and is enhanced 5-fold if 1,2-dioleoylglycerol is incorporated into the substrate dispersion.	diolein	119-139	glycophorin C (Gerbich blood group)	Homo sapiens	58-61
3353391-2	1988	Several protein kinase C activators including mezerein, dicaprin, diolein, and 1-oleoyl-2-acetyl-rac-glycerol were found to stimulate ODC activity as does prolactin.	diolein	66-73	ornithine decarboxylase, structural 1	Mus musculus	134-137
3740256-4	1986	Diolein (100 microM), which also stimulates protein kinase C activity in some systems, inhibited prolactin release by 21.3% (P less than 0.05).	diolein	0-7	prolactin	Homo sapiens	97-106
3259445-21	1988	However, inositol 1,4,5-triphosphate released Ca2+ from the stores and 1,2-diolein, an activator of protein kinase C, enhanced the contractions induced by 0.3 microM Ca2+.	diolein	71-82	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	166-169
3569305-5	1987	When cholesterol or 1,2-dioleoyl-glycerol was incorporated into phospholipid vesicles, the affinity of the liposomes for vimentin filaments was considerably increased.	diolein	20-41	vimentin	Homo sapiens	121-129
2881980-4	1987	Treatment of PC12 cells with 1-oleoyl-2-acetylglycerol also leads to increases in the phosphorylation and enzymatic activity of tyrosine hydroxylase; 1,2-diolein and 1,3-diolein are ineffective.	diolein	150-161	tyrosine hydroxylase	Rattus norvegicus	128-148
3155737-2	1985	The phosphorylation and concomitant inactivation of enzymic activity of HMG-CoA reductase was absolutely dependent on Ca2+, phosphatidylserine, and diolein.	diolein	148-155	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	72-89
3698022-1	1986	Phorbol esters trigger production of interleukin 2 by EL4 thymoma cells via an interaction with specific receptors, now considered to be identical with protein kinase C. Several in vitro substrates for protein kinase C were characterized by incubating cytosol from phorbol ester-responsive and -nonresponsive cells with [32P]adenosine triphosphate and CaCl2 with or without phosphatidylserine and diolein and separating proteins by gel electrophoresis.	diolein	397-404	interleukin 2	Mus musculus	37-50
5445-11	1976	Lipoprotein lipase was active against triolein, diolein, and monoolein, but not cholesterol oleate.	diolein	48-55	lipoprotein lipase	Gallus gallus	0-18
6240267-4	1984	In the presence of 1 microM Ca2+, a mixture of phosphatidylserine and diolein (or a potent tumor promoter phorbol ester) was required for optimal cytochrome P-450scc phosphorylation.	diolein	70-77	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	146-165
29132829-0	2018	The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase.	diolein	107-124	phospholipase A2 group IB	Homo sapiens	128-144
4422493-0	1974	Affinity chromatography of human adipose tissue triacylglycerol lipase on agarose-linked dioleoylglycerol.	diolein	89-105	lipase C, hepatic type	Homo sapiens	48-70
29132829-0	2018	The lipolytic degradation of highly structured cubic micellar nanoparticles of soy phosphatidylcholine and glycerol dioleate by phospholipase A2 and triacylglycerol lipase.	diolein	107-124	lipase C, hepatic type	Homo sapiens	149-171