PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15588084-3	2004	In the present paper we expanded SAR studies of 3, the ethyl analogue of the AChE inhibitor caproctamine (2), by investigating the role of its octamethylene spacer separating the two amide functions through the replacement with dipiperidine and dianiline moieties.	caproctamine	92-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
12620072-7	2003	With regard to the biological profile, the most interesting compound was the N-ethyl-analogue of caproctamine (9), that showed pIC(50) values of 7.73 (+/-0.02) and 5.65 (+/-0.03) against AChE and BChE, respectively.	caproctamine	97-109	acetylcholinesterase	Cavia porcellus	187-191
12620072-7	2003	With regard to the biological profile, the most interesting compound was the N-ethyl-analogue of caproctamine (9), that showed pIC(50) values of 7.73 (+/-0.02) and 5.65 (+/-0.03) against AChE and BChE, respectively.	caproctamine	97-109	cholinesterase	Cavia porcellus	196-200
19199985-3	2009	Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE).	caproctamine	53-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	191-211
12134831-1	2002	An RP-HPLC study for the pKa determination of a series of basic compounds related to caproctamine, a dibenzylaminediamide reversible inhibitor of acetylcholinesterase, is reported.	caproctamine	85-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-166
11141093-1	2001	In a search for less flexible analogues of caproctamine (1), a diamine diamide endowed with an interesting AChE affinity profile, we discovered compound 2, in which the terminal 2-methoxybenzyl groups of 1 have been incorporated into a tricyclic system.	caproctamine	43-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111
19199985-3	2009	Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE).	caproctamine	53-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	213-217