PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7576830-10	1995	The pyridostigmine inhibited AChE recovered only in the 100 mumol kg-1 kg oxime groups at the end of the experiment.	Oximes	74-79	acetylcholinesterase	Cavia porcellus	29-33
7476018-0	1995	Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants.	Oximes	42-47	butyrylcholinesterase	Homo sapiens	109-123
7799993-8	1995	In humans, the efficacy of oximes in AChE reactivation can be determined rapidly using electrophysiologic studies.	Oximes	27-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-41
7840615-1	1995	The oxolanosterol oxime 3 beta-hydroxylanost-7-en-15-one 15-oxime and the structurally similar 3 beta-hydroxylanost-7-en-15-one are dual-action inhibitors of cholesterol synthesis which cause both inhibition of lanosterol 14 alpha-methyl demethylase and suppression of the rate-limiting enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR).	Oximes	18-23	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	294-341
7840615-1	1995	The oxolanosterol oxime 3 beta-hydroxylanost-7-en-15-one 15-oxime and the structurally similar 3 beta-hydroxylanost-7-en-15-one are dual-action inhibitors of cholesterol synthesis which cause both inhibition of lanosterol 14 alpha-methyl demethylase and suppression of the rate-limiting enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR).	Oximes	18-23	high mobility group AT-hook 1	Homo sapiens	343-347
7654137-14	1995	The oxime efficacy in reactivating diaphragm AChE decreased in the order sarin > VX without significant differences between pretreated and non-pretreated groups.	Oximes	4-9	acetylcholinesterase	Cavia porcellus	45-49
8750900-4	1995	With HI 6 alone, the portion of AChE activity which could be reactivated 25 min after the start of ageing decreased rapidly with the delay of the oxime addition (100% of the original activity at immediate addition), the half-life being approximately 2.5 min.	Oximes	146-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-36
7670367-0	1995	Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates.	Oximes	0-5	acetylcholinesterase	Bos taurus	76-96
7778760-1	1995	We have developed an assay for pyridoxal kinase which takes advantage of the intense fluorescence yield of the oxime of pyridoxal or pyridoxal-5"-phosphate and the substantial difference in the rates of formation of these two oximes.	Oximes	111-116	pyridoxal kinase	Homo sapiens	31-47
7778760-1	1995	We have developed an assay for pyridoxal kinase which takes advantage of the intense fluorescence yield of the oxime of pyridoxal or pyridoxal-5"-phosphate and the substantial difference in the rates of formation of these two oximes.	Oximes	226-232	pyridoxal kinase	Homo sapiens	31-47
7758210-8	1995	Reactivation of carbamylated cholinesterase is obtained by the incubation of diluted enzyme at 37 degrees C for 2.5 h prior to assay, whereas phosphorylated (non-aged) enzyme is reactivated by a 30 min incubation with oximes.	Oximes	218-224	butyrylcholinesterase	Homo sapiens	29-43
8161944-0	1994	Rate constants of carbamylation and decarbamylation of acetylcholinesterase for physostigmine and carbaryl in the presence of an oxime.	Oximes	129-134	acetylcholinesterase	Bos taurus	55-75
8134223-13	1994	In vitro, oximes reactivated acetylcholinesterase inhibited with paraoxon, whereas no significant effect of oximes on carbamylated enzyme activity was observed.	Oximes	10-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-49
8161944-7	1994	The results extend those in a recent report by other authors who studied the half-life of carbamylation for acetylcholinesterase and butyrylcholinesterase in an attempt to understand the mechanism by which oximes increase the toxicity of carbaryl in vivo.	Oximes	206-212	acetylcholinesterase	Bos taurus	108-128
8304979-3	1994	To improve the efficacy of cholinesterases as pretreatment drugs, we have developed an approach in which the catalytic activity of OP-inhibited FBS AChE was rapidly and continuously restored, thus detoxifying the OP and minimizing enzyme aging by having sufficient amounts of appropriate oxime present.	Oximes	288-293	acetylcholinesterase	Mus musculus	148-152
8291056-13	1994	Both paraoxon- and DFP-exposed cultures recovered ACHE activity immediately following OP exposure if treated postexposure with an oxime reactivator, 2-pralidoxime.	Oximes	130-135	acetylcholinesterase (Cartwright blood group)	Gallus gallus	50-54
7857205-0	1994	In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human.	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-102
7857205-3	1994	In the Pre-Post mode the oxime effects would result from a combination of not only shielding of acetylcholinesterase from soman inhibition but also from immediate reactivation of soman-inhibited acetylcholinesterase.	Oximes	25-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
7857205-3	1994	In the Pre-Post mode the oxime effects would result from a combination of not only shielding of acetylcholinesterase from soman inhibition but also from immediate reactivation of soman-inhibited acetylcholinesterase.	Oximes	25-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-215
7857205-9	1994	Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase.	Oximes	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-83
7857205-9	1994	Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase.	Oximes	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
7857205-9	1994	Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase.	Oximes	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
8308950-6	1994	We propose that stability of the plasma cholinesterase at 6 to 8 h after temporarily suspending oxime provides a rapid guide to the duration of therapy, especially in patients whose complications make clinical assessment difficult.	Oximes	96-101	butyrylcholinesterase	Homo sapiens	40-54
8344000-1	1993	O-Ethyl-O-4-nitrophenylphosphoramidate is a short-acting anticholinesterase and a possible candidate for a prophylactic agent against nerve agents since human acetylcholinesterase inhibited by this agent undergoes rapid spontaneous reactivation which can be accelerated further, if necessary, by treatment with oximes.	Oximes	311-317	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
8292752-5	1993	The rat brain acetylcholinesterase spontaneous (k0 = approximately 13.0 x 10(-3) min-1) and oxime-mediated (koxime) = 51.0 x 10(-3) min-1) reactivation rate constants following inhibition by isomalathion stereoisomers with the R configuration at phosphorus were comparable to spontaneous (11.3 x 10(-3) min-1) and oxime-mediated (50.2 x 10(-3) min-1) reactivation rates obtained for (S)-isoparathion methyl.	Oximes	92-97	acetylcholinesterase	Rattus norvegicus	14-34
8292752-5	1993	The rat brain acetylcholinesterase spontaneous (k0 = approximately 13.0 x 10(-3) min-1) and oxime-mediated (koxime) = 51.0 x 10(-3) min-1) reactivation rate constants following inhibition by isomalathion stereoisomers with the R configuration at phosphorus were comparable to spontaneous (11.3 x 10(-3) min-1) and oxime-mediated (50.2 x 10(-3) min-1) reactivation rates obtained for (S)-isoparathion methyl.	Oximes	109-114	acetylcholinesterase	Rattus norvegicus	14-34
1361555-5	1992	The reactivation of cholinesterase in cerebral cortex by the oximes, in spite of their being quaternary salts is a notable feature.	Oximes	61-67	butyrylcholinesterase	Homo sapiens	20-34
8311691-1	1993	The ability of three oximes, HI-6, MMB-4 and ICD-467, to reactivate cholinesterase (ChE) inhibited by the organophosphorus compound soman was compared in blood (plasma and erythrocytes), brain regions (including spinal cord) and peripheral tissues of rats.	Oximes	21-27	butyrylcholinesterase	Rattus norvegicus	84-87
8494501-11	1993	Combination of pyridostigmine pretreatment and oxime treatment enhanced the recovery of the tracheal contraction response and the ChE activity in the trachea compared to treatment with oximes alone.	Oximes	47-52	butyrylcholinesterase	Rattus norvegicus	130-133
8448346-3	1993	Following inhibition of rat brain AChE by (SPRC)- or (SPSC)-isomalathion, k0 and k(oxime) values were obtained that were comparable to (SP)-isoparathion methyl, indicating that the same mechanism of inhibition was shared, namely, formation of an O,S-dimethyl phosphorothiolated enzyme.	Oximes	83-88	acetylcholinesterase	Rattus norvegicus	34-38
1664202-1	1991	Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime.	Oximes	84-89	butyrylcholinesterase	Rattus norvegicus	100-114
8441737-7	1993	The addition of HI-6, an AChE-reactivating oxime, to atropine + diazepam therapy further increased the survival in soman-poisoned and physostigmine-pretreated rats, yielding the highest protective ratio of 6.4.	Oximes	43-48	acetylcholinesterase	Rattus norvegicus	25-29
1631893-1	1992	The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys.	Oximes	32-37	cholinesterase	Callithrix jacchus	86-100
1631893-1	1992	The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys.	Oximes	32-37	cholinesterase	Callithrix jacchus	102-105
1733041-0	1992	Central activity of acetylcholinesterase oxime reactivators.	Oximes	41-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
1733041-1	1992	The ability of various oximes to antagonize the sarin-induced hypothermia and reactivate phosphorylated acetylcholinesterase was used as an indicator of the central activity of oximes.	Oximes	23-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-124
1778361-1	1991	Phrenic nerve diaphragm muscles of young adult rats were used to study the ability of the oximes 2-PAM and HI-6 to recover muscle function depressed by organophosphate (OP) agents.	Oximes	90-96	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	99-102
1890690-6	1991	The oxime HI-6 reactivated soman phosphonylated enzymes to a considerably greater extent than other oximes, and FBS AChE was notably more responsive to HI-6 than to other oximes.	Oximes	171-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
1890690-8	1991	In general, oxime potency and some rank order varied with each inhibitor and with each AChE, although there was some similarity in oxime rank order between the two mammalian AChEs.	Oximes	12-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
1664331-0	1991	On the mechanism whereby HI-6 improves neuromuscular function after oxime-resistant acetylcholinesterase inhibition and subsequent impairment of neuromuscular transmission.	Oximes	68-73	acetylcholinesterase	Rattus norvegicus	84-104
1664331-1	1991	Experiments were performed to elucidate the mechanism of action by which the oxime HI-6 causes a recovery of neuromuscular function after oxime-resistant inhibition of acetylcholinesterase by the organophosphate S27.	Oximes	77-82	acetylcholinesterase	Rattus norvegicus	168-188
1412499-4	1992	We have found that the inhibition of both eel acetylcholinesterase (eel AChE, EC 3.1.1.7) and human serum cholinesterase (human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes.	Oximes	183-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
1412499-4	1992	We have found that the inhibition of both eel acetylcholinesterase (eel AChE, EC 3.1.1.7) and human serum cholinesterase (human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes.	Oximes	183-189	butyrylcholinesterase	Homo sapiens	52-66
1599796-6	1992	The method of introducing the amino functionality at the C-4 methylene group described herein provides an alternative to that currently in use (reduction of oximes).	Oximes	157-163	complement C4A (Rodgers blood group)	Homo sapiens	57-60
1459041-4	1992	In assessing therapeutic efficacy and oxime-induced reactivation of blood AChE, rats were pretreated with PYR, challenged with agent and treated with atropine (16 mg/kg, im) and HI-6 or 2-PAM (100 umoles/kg, im) 30 sec post agent.	Oximes	38-43	acetylcholinesterase	Rattus norvegicus	74-78
2029909-3	1991	Displaying inhibition constants of 0.45 microM and 0.62 microM, for the animal and plant enzyme, respectively, the simple oxime 2 was about equally potent as the parent lactone 1, and 50-400 times more efficient than two recently described new beta-N-acetylglucosaminidase inhibitors.	Oximes	122-127	O-GlcNAcase	Homo sapiens	244-272
2052186-2	1991	The maximal protection produced by the oximes PAM and HI-6 varied as much as 6-fold between these species.	Oximes	39-45	peptidylglycine alpha-amidating monooxygenase	Mus musculus	46-49
1664202-1	1991	Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime.	Oximes	84-89	butyrylcholinesterase	Rattus norvegicus	116-119
1664202-3	1991	Atropinized rats were artificially ventilated after injection with 3 x LD50 soman for 3 h and then treated with HI-6, i.e. at a time when oxime reactivation of soman inhibited ChE is no longer possible.	Oximes	138-143	butyrylcholinesterase	Rattus norvegicus	176-179
2046471-1	1991	To assess the utility of phosphinates as pretreatments against nerve agents, experiments were conducted to determine whether oximes can reactivate phosphinate-inhibited guinea pig acetylcholinesterase (AChE) and whether the toxicity of phosphinates is reduced by treatment with atropine and/or oxime.	Oximes	125-131	acetylcholinesterase	Cavia porcellus	202-206
2046471-1	1991	To assess the utility of phosphinates as pretreatments against nerve agents, experiments were conducted to determine whether oximes can reactivate phosphinate-inhibited guinea pig acetylcholinesterase (AChE) and whether the toxicity of phosphinates is reduced by treatment with atropine and/or oxime.	Oximes	125-130	acetylcholinesterase	Cavia porcellus	202-206
2046471-4	1991	Both oximes significantly reactivated MPP- or CMPP-inhibited AChE; however, HI-6 was the better reactivator in both cases.	Oximes	5-11	acetylcholinesterase	Cavia porcellus	61-65
1992286-1	1991	C-6 derivatives--hydrazones, phenylhydrazones, dinitrophenylhydrazones, oximes and semicarbazones--of morphinane-6-ones were synthesized and their binding characteristics were studied on rat brain membranes.	Oximes	72-78	complement C6	Rattus norvegicus	0-3
1658986-3	1991	CRS-inhibited AChE appeared to age very rapidly, because in vitro addition of oximes immediately following inhibition, did not result in any AChE reactivation.	Oximes	78-84	acetylcholinesterase	Rattus norvegicus	14-18
2260991-0	1990	Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits.	Oximes	22-28	ACE-1	Oryctolagus cuniculus	83-103
2260991-1	1990	The antidotal benefit of oximes against organophosphorus (OP) anticholinesterase intoxication is thought to be due to reactivation of the OP-inhibited acetylcholinesterase (AChE).	Oximes	25-31	ACE-1	Oryctolagus cuniculus	151-171
2260991-1	1990	The antidotal benefit of oximes against organophosphorus (OP) anticholinesterase intoxication is thought to be due to reactivation of the OP-inhibited acetylcholinesterase (AChE).	Oximes	25-31	ACE-1	Oryctolagus cuniculus	173-177
2260991-2	1990	This study was conducted to determine whether the antidotal efficacy against soman by the oximes 2-hydroxyiminomethyl-3-methyl-1-[2-(3-methyl-3-nitrobutyl oxymethyl)]-imidazolium Cl (ICD 467) and 1,1"-methylenebis[4-(hydroxyiminomethyl) pyridinium] di-Cl (MMB-4) resulted, in part, from reactivation of the inhibited AChE.	Oximes	90-96	ACE-1	Oryctolagus cuniculus	317-321
2260991-3	1990	These oximes were tested in parallel with pralidoxime Cl (2-PAM) and 1-(2-hydroxyiminomethyl-1-pyridinio-3-(4-carbamoyl-1-pyridinio+ ++)-2-oxapropane di-Cl (HI-6).	Oximes	6-12	peptidyl-glycine alpha-amidating monooxygenase	Oryctolagus cuniculus	60-63
2362084-0	1990	Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
2362084-1	1990	The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor.	Oximes	27-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-88
2362084-1	1990	The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor.	Oximes	27-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
2362084-3	1990	This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning.	Oximes	93-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77
2362084-6	1990	Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates.	Oximes	81-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
2362084-6	1990	Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates.	Oximes	107-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
2362084-6	1990	Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates.	Oximes	107-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
2403479-1	1990	The use of oxime reactivators of inhibited cholinesterase enzymes in poisoning by carbamate compounds has received mixed reviews in the medical literature.	Oximes	11-16	butyrylcholinesterase	Homo sapiens	43-57
33802843-11	2021	Our present data, together with previous results on other OPCs, indicate that the experimental oximes K-27 and K-48 are very promising pretreatment compounds.	Oximes	95-101	keratin 27	Rattus norvegicus	102-106
33872504-2	2021	Our convergent synthesis features a [3+2] dipolar cycloaddition of an olefin-bearing 1,3-syn diol unit and an oxime segment containing 1,2-syn diol functionality as the key step.	Oximes	110-115	synemin	Homo sapiens	15-18
33588047-3	2021	We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE).	Oximes	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196
33588047-3	2021	We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE).	Oximes	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	203-207
34846842-4	2021	The labeled O-GlcNAc glycopeptides could be efficiently enriched based on the equilibrium between the hydrazine and oxime bonds.	Oximes	116-121	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	12-20
34968725-8	2022	To this end, we conjugated aldehyde-tagged Env with Propargyl-PEG3-aminooxy linker (oxime ligation; Step-one) and coupled these conjugates by copper-catalyzed azide-alkyne cycloaddition (Click reaction; Step-two) to calcium phosphate nanoparticles (CaPs) functionalized with terminal azide groups.	Oximes	84-89	endogenous retrovirus group W member 1, envelope	Homo sapiens	43-46
34844036-0	2022	Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells.	Oximes	62-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	79-84
34844036-0	2022	Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells.	Oximes	62-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
34844036-1	2022	Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes were designed as potential HSP90 inhibitors.	Oximes	62-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	96-101
34145064-2	2021	In considering dosing requirements for oxime antidotes in OP exposures that inactivate AChE, clearance of proton ionizable, zwitterionic antidotes is rapid and proceeds with largely the parent antidotal compound being cleared by renal transporters.	Oximes	39-44	acetylcholinesterase	Mus musculus	87-91
34796899-7	2021	The stable oxime makes extensive interactions with ODC but cannot be catabolized, explaining APA"s high potency in ODC inhibition.	Oximes	11-16	ornithine decarboxylase 1	Homo sapiens	51-54
34796899-7	2021	The stable oxime makes extensive interactions with ODC but cannot be catabolized, explaining APA"s high potency in ODC inhibition.	Oximes	11-16	ornithine decarboxylase 1	Homo sapiens	115-118
34399903-3	2021	Based on chemoselective formation of oximes by solid phase immobilized hydroxylamine derivatives we proposed the protocol for derivatization and selective detection of carbonylated compounds in human serum albumin hydrolysate as a complex peptide mixture and of testosterone in urine samples.	Oximes	37-43	albumin	Homo sapiens	200-213
34773452-1	2021	A series of 5-(4-pyridyl)-1,2,4-triazoles hybrids with acetophenones and their oxime derivatives was rationally designed and synthesized as epidermal growth factor receptor (EGFR) kinase inhibitors.	Oximes	79-84	epidermal growth factor receptor	Homo sapiens	140-172
34773452-1	2021	A series of 5-(4-pyridyl)-1,2,4-triazoles hybrids with acetophenones and their oxime derivatives was rationally designed and synthesized as epidermal growth factor receptor (EGFR) kinase inhibitors.	Oximes	79-84	epidermal growth factor receptor	Homo sapiens	174-178
34558680-0	2022	Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation.	Oximes	6-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-79
34558680-2	2022	Here, we describe synthesis, photochemical properties, and biochemical activities of two caged oxime compounds applied in the photocontrolled reactivation of the AChE inactivated by reactive organophosphate.	Oximes	95-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-166
34558680-3	2022	Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class.	Oximes	77-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
34577159-3	2021	We synthesized 13 derivatives of our reported JNK inhibitor 11H-indeno(1,2-b)quinoxalin-11-one oxime and evaluated their binding to the three JNK isoforms and their biological effects.	Oximes	95-100	mitogen-activated protein kinase 8	Homo sapiens	46-49
34577159-3	2021	We synthesized 13 derivatives of our reported JNK inhibitor 11H-indeno(1,2-b)quinoxalin-11-one oxime and evaluated their binding to the three JNK isoforms and their biological effects.	Oximes	95-100	mitogen-activated protein kinase 8	Homo sapiens	142-145
34541552-3	2021	Reactivation of inhibited hAChE can be achieved with nucleophilic antidotes, such as oximes.	Oximes	85-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-31
34541552-5	2021	Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution.	Oximes	166-171	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-150
34324828-5	2021	We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE.	Oximes	115-121	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-193
34324828-6	2021	However, binding of oximes to the native ligand-free hAChE, binding of high-affinity reversible ligands, or formation of a SP-sarin-hAChE conjugate had no effect on homodimerization.	Oximes	20-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-58
34671741-0	2021	Dual acting oximes designed for therapeutic decontamination of reactive organophosphates via catalytic inactivation and acetylcholinesterase reactivation.	Oximes	12-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-140
34671741-5	2021	This library was screened by enzyme assays performed with human and electric eel subtypes of OP-inactivated AChE, which led to identifying three oxime leads that displayed significant enhancements in reactivation activity comparable to 2-PAM.	Oximes	145-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
34067242-4	2021	Some oximes are inhibitors of lipoxygenase 5, human neutrophil elastase, and proteinase 3.	Oximes	5-11	elastase, neutrophil expressed	Homo sapiens	52-71
34330964-2	2021	The current standard treatment against their effects relies on the use of small molecule-based oximes that can efficiently restore acetylcholinesterase (AChE) activity.	Oximes	95-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-151
34330964-2	2021	The current standard treatment against their effects relies on the use of small molecule-based oximes that can efficiently restore acetylcholinesterase (AChE) activity.	Oximes	95-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
34067242-4	2021	Some oximes are inhibitors of lipoxygenase 5, human neutrophil elastase, and proteinase 3.	Oximes	5-11	proteinase 3	Homo sapiens	77-89
35628301-0	2022	Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.	Oximes	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
35489467-0	2022	Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok).	Oximes	57-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	28-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	255-259
35631423-3	2022	The oxime radiotracers were produced by condensation of an aminooxy functionalized PSMA-inhibitor Lys-Urea-Glu scaffold with fluorine-18-labeled aldehydes.	Oximes	4-9	folate hydrolase 1	Homo sapiens	83-87
35525902-0	2022	Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia.	Oximes	0-5	dual oxidase 2	Homo sapiens	96-109
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	28-34	butyrylcholinesterase	Homo sapiens	264-268
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	48-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	255-259
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	48-54	butyrylcholinesterase	Homo sapiens	264-268
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	79-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	255-259
35526478-2	2022	Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE.	Oximes	79-84	butyrylcholinesterase	Homo sapiens	264-268
35526478-6	2022	The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE.	Oximes	62-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	247-251
35526478-6	2022	The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE.	Oximes	62-67	butyrylcholinesterase	Homo sapiens	256-260
35526478-6	2022	The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE.	Oximes	221-227	acetylcholinesterase (Cartwright blood group)	Homo sapiens	247-251
35526478-6	2022	The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE.	Oximes	221-227	butyrylcholinesterase	Homo sapiens	256-260
2818204-2	1989	The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides.	Oximes	54-59	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	63-66
35164361-1	2022	A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered.	Oximes	32-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
35527825-2	2022	We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids.	Oximes	147-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
35025136-5	2022	Here, we combined genetic code expansion with oxime ligation to generate p53 site-specifically mono-ubiquitylated at position 120.	Oximes	46-51	tumor protein p53	Homo sapiens	73-76
2613337-4	1989	The most notable differences in substrate profiles between the extended broad spectrum enzymes and TEM-2 enzymes occurred with oxime-containing antibiotics.	Oximes	127-132	RASD family member 2	Homo sapiens	99-104
2605226-6	1989	The maximum of the difference spectrum between either chicken red or rhodopsin and its photoproduct (all-trans-retinal oxime plus opsin) was determined to be 571 or 503 nm, respectively.	Oximes	119-124	rhodopsin	Gallus gallus	69-78
2605226-6	1989	The maximum of the difference spectrum between either chicken red or rhodopsin and its photoproduct (all-trans-retinal oxime plus opsin) was determined to be 571 or 503 nm, respectively.	Oximes	119-124	opsin 1 (cone pigments), short-wave-sensitive (violet cone opsin)	Gallus gallus	73-78
2494778-0	1989	The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication.	Oximes	25-30	acetylcholinesterase	Rattus norvegicus	68-88
2917984-2	1989	With the exception of the conjugate formed from reaction of AchE with RP-cycloheptyl methylphosphonyl thiocholine, all enantiomeric conjugates underwent oxime reactivation at rates that were within 2-3-fold of each other.	Oximes	153-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
2596267-1	1989	It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE.	Oximes	40-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
2596267-1	1989	It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE.	Oximes	40-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86
2596267-1	1989	It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE.	Oximes	40-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	355-359
2796731-8	1989	The use of oximes (PAM and Toxobidine) considerably contributed to reactivation of AChE and ChE and to normalization of the test marker enzymes.	Oximes	11-17	acetylcholinesterase	Rattus norvegicus	83-87
2903553-1	1988	A peptide 60 residues in length that corresponds to the homeo domain of Antennapedia (Antp), a protein governing development in Drosophila, was synthesized by segment condensation with protected peptide segments prepared on an oxime resin.	Oximes	227-232	Antennapedia	Drosophila melanogaster	72-84
2903553-1	1988	A peptide 60 residues in length that corresponds to the homeo domain of Antennapedia (Antp), a protein governing development in Drosophila, was synthesized by segment condensation with protected peptide segments prepared on an oxime resin.	Oximes	227-232	Antennapedia	Drosophila melanogaster	86-90
2452874-1	1988	Interactions of the oximes pyridine-2-aldoxime (2-PAM) and 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino++ +)-2-oxapropane dichloride (HI-6), reactivators of phosphorylated acetylcholinesterase enzyme, with the nicotinic acetylcholine receptor-ion channel complex were studied using electrophysiological techniques.	Oximes	20-26	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	50-53
3057326-4	1988	The mechanism of action of organophosphates has been determined in some depth; the understanding of the toxic effects resulting from the inhibition of cholinesterase activity, causing accumulation of acetylcholine at nerve endings has played a major part in providing a rationale for specific antidote treatment using atropine and oximes.	Oximes	331-337	butyrylcholinesterase	Homo sapiens	151-165
3345199-1	1988	Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex.	Oximes	162-168	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
3345199-1	1988	Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex.	Oximes	162-168	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
3827595-6	1986	The concentration of the oxime in CSF increased rapidly during the absorption phase (by 30 min after injection).	Oximes	25-30	colony stimulating factor 2	Canis lupus familiaris	34-37
3299873-5	1987	The serum oxime concentrations (ED50 values) for HI-6, obidoxime, and PAM against a 3 LD50 dose of sarin were 0.72, 9.05, and 2.56 micrograms/ml, respectively.	Oximes	10-15	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	70-73
3566284-0	1987	Oxime-metabolizing activity of liver aldehyde oxidase.	Oximes	0-5	aldehyde oxidase 1	Homo sapiens	37-53
3566284-1	1987	Liver aldehyde oxidase in the presence of its electron donor exhibited a significant oxime-metabolizing activity toward some different types of oximes under anaerobic conditions.	Oximes	85-90	aldehyde oxidase 1	Homo sapiens	6-22
3566284-1	1987	Liver aldehyde oxidase in the presence of its electron donor exhibited a significant oxime-metabolizing activity toward some different types of oximes under anaerobic conditions.	Oximes	144-150	aldehyde oxidase 1	Homo sapiens	6-22
3566284-5	1987	We propose a mechanism of oxime biotransformation that liver aldehyde oxidase catalyzes the reduction of oximes to the corresponding ketimines which in turn undergo, depending on their chemical stability, nonenzymatic hydrolysis to the corresponding oxo compounds and ammonia.	Oximes	26-31	aldehyde oxidase 1	Homo sapiens	61-77
3566284-5	1987	We propose a mechanism of oxime biotransformation that liver aldehyde oxidase catalyzes the reduction of oximes to the corresponding ketimines which in turn undergo, depending on their chemical stability, nonenzymatic hydrolysis to the corresponding oxo compounds and ammonia.	Oximes	105-111	aldehyde oxidase 1	Homo sapiens	61-77
3807651-1	1987	The generally accepted explanation for the effects of oximes in countering organophosphorus (OP) anticholinesterase is reactivation of the inhibited acetylcholinesterase (AChE).	Oximes	54-60	acetylcholinesterase	Cavia porcellus	149-169
3807651-1	1987	The generally accepted explanation for the effects of oximes in countering organophosphorus (OP) anticholinesterase is reactivation of the inhibited acetylcholinesterase (AChE).	Oximes	54-60	acetylcholinesterase	Cavia porcellus	171-175
3807651-2	1987	With soman, the inhibited AChE rapidly becomes resistant to oxime reactivation due to a phenomenon called aging.	Oximes	60-65	acetylcholinesterase	Cavia porcellus	26-30
3807651-9	1987	The data from in vitro and in vivo experiments revealed that oximes accelerated the decarbamylation (p less than 0.05) of inhibited AChE.	Oximes	61-67	acetylcholinesterase	Cavia porcellus	132-136
2452874-8	1988	Our study demonstrates a direct molecular interaction of the oximes HI-6 and 2-PAM with the natural agonist molecule and with the acetylcholine receptor-ion channel complex.	Oximes	61-67	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	79-82
3746817-5	1986	In this series, varying R substituents on the aryl ring produced compounds with oxime pKa values from 6.8 to 8.0, optimum for an AChE reactivator.	Oximes	80-85	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
3954783-3	1986	The rates of inhibition of AChE by these phosphylated oximes and the parent (and related) organophosphates have also been measured.	Oximes	54-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-31
2423865-8	1986	Monoclonal antibodies raised against the oxime conjugate such as 258(2)-1 (herein referred to as mAb D) primarily recognized chemical determinants in ring 2 and the tertiary amino group of the piperidine ring.	Oximes	41-46	H2-K region expressed gene 6	Mus musculus	150-156
3751113-5	1986	The oxime metabolites were formed as mixtures of two geometric isomers, Z (syn-phenyl) and E (anti-phenyl), wherein the phenyl and hydroxyl group are cis and trans to each other respectively.	Oximes	4-9	synemin	Homo sapiens	75-78
3972833-6	1985	NBD-aminoethyl methylphosphono-acetylcholinesterase undergoes oxime-induced as well as spontaneous reactivation at rates that are 3.6 and 35 times faster, respectively, than the corresponding rates measured for the NBD-aminopentyl conjugate.	Oximes	62-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
3951676-2	1986	However, a partial protection of AChE in brain against inhibition by soman was obtained in anaesthetized, atropinized rats by the oxime injected into the cerebral ventricle 5 min before parenteral exposure to soman.	Oximes	130-135	acetylcholinesterase	Rattus norvegicus	33-37
6389867-6	1984	Thus structural changes at the C-6 position to produce diaziridines, oximes, and oxime O-methyl ethers provide compounds retaining expected opioid activity.	Oximes	69-75	complement C6	Homo sapiens	31-34
6710513-3	1984	Atropine and the oximes were less effective as profenofos antidotes, indicating that profenofos-inhibited AChE may undergo rapid aging.	Oximes	17-23	acetylcholinesterase	Mus musculus	106-110
6497906-0	1984	The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.	Oximes	20-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
6497906-1	1984	A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme.	Oximes	47-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
6497906-1	1984	A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme.	Oximes	47-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
6151379-0	1984	[Adrenergic beta 1 and beta 2 blocking activity of new aminopropanols derived from oximes and esters].	Oximes	83-89	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-29
6098298-2	1984	The difference absorption spectrum between the cyclopentatrienylidene 11-cis-locked-rhodopsin and its retinal oxime had its maximum at 495 nm (P-495).	Oximes	110-115	rhodopsin	Bos taurus	84-93
20487840-4	1981	Rapid hydrolysis of phosphonylated acetylcholinesterase can be brought about by oximes, but dealkylation of the phosphonyl group on the enzyme (known as ageing) renders the inhibited enzyme insensitive to oximes.	Oximes	80-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
6871372-2	1983	In both chloroform and carbon tetrachloride solutions, the exocyclic N4-methoxy group of N4-methoxycytosine, and of 5-methyl N4-methoxycytosine (which is in the oxime form under these conditions), is so oriented that it is predominantly syn to the ring N(3), and neither compound forms planar auto-associates.	Oximes	161-166	synemin	Homo sapiens	237-240
6628257-5	1983	The effectiveness of these oximes in restoration of VX-inactivated ChE in vivo offers an explanation as to why conventional atropine/oxime therapy is so effective against VX intoxication.	Oximes	27-33	butyrylcholinesterase	Rattus norvegicus	67-70
6628257-5	1983	The effectiveness of these oximes in restoration of VX-inactivated ChE in vivo offers an explanation as to why conventional atropine/oxime therapy is so effective against VX intoxication.	Oximes	27-32	butyrylcholinesterase	Rattus norvegicus	67-70
6655549-0	1983	Antigenic properties of estriol 3-glucuronide-[C-6]-bovine serum albumin conjugates having oxime bridges.	Oximes	91-96	LOW QUALITY PROTEIN: complement component C6	Oryctolagus cuniculus	47-50
6655549-0	1983	Antigenic properties of estriol 3-glucuronide-[C-6]-bovine serum albumin conjugates having oxime bridges.	Oximes	91-96	albumin	Oryctolagus cuniculus	59-72
7100228-0	1982	Modification of the level of acetylcholinesterase activity by two oximes in certain brain regions and peripheral tissues of paraoxon treated rats.	Oximes	66-72	acetylcholinesterase	Rattus norvegicus	29-49
6461392-1	1982	A method is described for the extraction of urinary organic acids in children, their conversion to TMS and oxime TMS derivatives and their separation by gas liquid chromatography on a packed column of 10% OV 101.	Oximes	107-112	PYD and CARD domain containing	Homo sapiens	113-116
7014032-7	1981	Moreover, the glucose oxidase and the oxime methods for determination of glucose and urea were found to give significantly lower values than the hexokinase and urease methods, respectively.	Oximes	38-43	hexokinase 1	Homo sapiens	145-155
6262099-2	1981	It was found that the oxime-mediated recovery of function in both tissues of the rat and guinea pig was composed of direct oxime actions, AChE reactivation and adaptation.	Oximes	22-27	acetylcholinesterase	Cavia porcellus	138-142
7281197-0	1981	Continual monitoring of the reactivation effect of oximes on blood acetylcholinesterase in the rats poisoned with organophosphates.	Oximes	51-57	acetylcholinesterase	Rattus norvegicus	67-87
7426043-0	1980	Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes.	Oximes	129-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
799866-2	1976	Described is an activating affect (observed for the first time in vivo) on ChE preduced by low and very low concentrations of reactivators of the group of oximes.	Oximes	155-161	butyrylcholinesterase	Rattus norvegicus	75-78
1015993-0	1976	Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives.	Oximes	45-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-30
1015993-1	1976	Out of 12 oximes and amidoximes (3 of which were new to the literature) the following showed a distinct antilethal effect in DFP poisoning: RA14 (1-methylbenzimidazole-2-aldoxime methiodide), RA14 (pyridine-4-aldoxime dodecyl bromide), and RA24 (pyridine-2-aldoxime dodecyl bromide).	Oximes	10-16	RA14	Homo sapiens	140-144
497002-0	1979	Some adjuncts to oxime-atropine therapy for organophosphate intoxication--their effects on acetylcholinesterase.	Oximes	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
435080-5	1979	The oximes with a hydroxyiminomethyl group in position 4 in the pyridinium ring were good reactivators of both phosphorylated and phosphonylated acetylcholinesterase.	Oximes	4-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-165
799866-4	1976	The low concentrations of the specific oxime ractivators of ChE, followed up by ChDT, can be used as sensitive quantitative indicators of the activity of ChE.	Oximes	39-44	butyrylcholinesterase	Rattus norvegicus	60-63
799866-4	1976	The low concentrations of the specific oxime ractivators of ChE, followed up by ChDT, can be used as sensitive quantitative indicators of the activity of ChE.	Oximes	39-44	butyrylcholinesterase	Rattus norvegicus	154-157
18961635-1	1975	A rapid method of simultaneous spectrophotometric determination of up to 4 ppm of iron(II) and 20 ppm of copper(II) in a mixture by chloroform extraction of the syn-phenyl-alpha-pyridyl ketoxime complexes at pH 10.0, is developed.	Oximes	186-194	synemin	Homo sapiens	161-164
4363351-0	1973	[Proceedings: Relationship of serum cholinesterase level in chronic alcoholic liver disease and appearance of delirium tremens: therapeutic effect of oximes].	Oximes	150-156	butyrylcholinesterase	Homo sapiens	36-50
4751672-0	1973	Reactivation of phosphorylated cholinesterase by some imidazole-substituted oximes.	Oximes	76-82	butyrylcholinesterase	Homo sapiens	31-45
4669224-0	1972	[Competition of an oxime in the binding of cholinesterase and tetanus toxin].	Oximes	19-24	butyrylcholinesterase	Homo sapiens	43-57
4110154-11	1972	A wet paste of rhodopsin-digitonin micelles, sheared between glass slides, becomes highly oriented, the rhodopsin chromophores lining up in the direction of shear, the retinal oxime produced by bleaching orienting more perpendicularly to the shear.	Oximes	176-181	rhodopsin	Homo sapiens	15-24
4110154-11	1972	A wet paste of rhodopsin-digitonin micelles, sheared between glass slides, becomes highly oriented, the rhodopsin chromophores lining up in the direction of shear, the retinal oxime produced by bleaching orienting more perpendicularly to the shear.	Oximes	176-181	rhodopsin	Homo sapiens	104-113
14249424-0	1964	OXIMES ANTAGONISTIC TO INHIBITORS OF CHOLINESTERASE.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	37-51
5315345-2	1971	From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes.	Oximes	90-96	butyrylcholinesterase	Rattus norvegicus	62-76
5315345-2	1971	From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes.	Oximes	257-263	butyrylcholinesterase	Rattus norvegicus	62-76
5439615-0	1970	[Acetylcholinesterase at the motor end plate of the rat diaphragm after poisoning with Paraoxon and Soman during application of oximes].	Oximes	128-134	acetylcholinesterase	Rattus norvegicus	0-21
5702864-0	1968	[Behavior of cholinesterase in the blood in relation to treatment with oximes in a case of acute rogor poisoning].	Oximes	71-77	butyrylcholinesterase	Homo sapiens	13-27
5594205-0	1967	[Study of the action in vitro of some new oximes on normal cholinesterase and cholinesterase blocked by toxic organophosphoric compounds].	Oximes	42-48	butyrylcholinesterase	Homo sapiens	59-73
5594205-0	1967	[Study of the action in vitro of some new oximes on normal cholinesterase and cholinesterase blocked by toxic organophosphoric compounds].	Oximes	42-48	butyrylcholinesterase	Homo sapiens	78-92
6027243-0	1967	Oxime reactivation of diethylphosphoryl human serum cholinesterase.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	52-66
5881660-0	1965	Oxime reactivation of erythrocyte cholinesterase inhibited by ethyl p-nitrophenyl ethylphosphonate.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	34-48
14234924-0	1964	OXIMES ANTAGONISTIC TO INHIBITORS OF CHOLINESTERASE.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	37-51
14450082-0	1961	The neutralization of cholinesterase inhibition by various oximes and by atropine.	Oximes	59-65	butyrylcholinesterase	Homo sapiens	22-36
14126349-0	1964	[EFFECT OF VARIOUS OXIMES DERIVED FROM 1-PHENYL, 1-BENZYL AND 1-PHENACYL PYRIDINE AND ANALOGUES OF 4-FORMYL PYRIDINE IN PARAOXON INTOXICATION].	Oximes	19-25	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	58-63
14026286-3	1962	Prophylactic oxime (2 g. PAM chloride orally) is recommended if the situation permits.	Oximes	13-18	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	25-28
14463753-5	1962	Strips treated with a high concentration of oxime, sufficient to cause 100% reactivation of cholinesterase, exhibit normal control tone and motility after washing.	Oximes	44-49	cholinesterase	Oryctolagus cuniculus	92-106
13918437-0	1961	Pharmacological studies of cholinesterase reactivating oximes.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	27-41
14442184-0	1959	Oxime reactivation studies of inhibited true and pseudo cholinesterase.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	56-70
14442185-0	1959	Oxime reactivation studies of inhibited true and pseudo cholinesterase.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	56-70
13355845-0	1956	The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds.	Oximes	33-39	butyrylcholinesterase	Homo sapiens	44-58
13526753-0	1957	[Organization of medical aid in phosgene-oxime poisoning].	Oximes	41-46	activation induced cytidine deaminase	Homo sapiens	25-28
13276605-0	1955	The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds.	Oximes	20-26	butyrylcholinesterase	Homo sapiens	51-65
33990679-0	2021	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase.	Oximes	15-21	butyrylcholinesterase	Homo sapiens	87-108
34019427-0	2021	Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.	Oximes	10-15	acetylcholinesterase	Mus musculus	33-53
34019427-1	2021	Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
34019427-1	2021	Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
33990679-2	2021	Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
33990679-2	2021	Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	85-106
33990679-2	2021	Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs.	Oximes	0-5	butyrylcholinesterase	Homo sapiens	108-112
33990679-6	2021	EMP-MeCyC detoxification and EMP-BChE reactivation screening campaigns of ~155,000 small molecules resulted in the identification of 33 nucleophile candidates, including non-quaternary oximes.	Oximes	185-191	butyrylcholinesterase	Homo sapiens	33-37
33990679-7	2021	Four of the oximes were reactivators of both Sarin- and VX-inhibited BChE and directly detoxified Sarin.	Oximes	12-18	butyrylcholinesterase	Homo sapiens	69-73
33540058-4	2021	For this, (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one (Cl-HIN), a compound that has properties of isatin and oxime in its structure, have shown reactivating properties in the activity of AChE that have been added to antidepressant-like effects in rats exposed to malathion in acute protocol.	Oximes	109-114	acetylcholinesterase	Rattus norvegicus	187-191
33545185-0	2021	Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study.	Oximes	31-36	acetylcholinesterase	Rattus norvegicus	52-72
33545185-1	2021	Oxime reactivators of acetylcholinesterase (AChE) represent an integral part of standard antidote treatment of organophosphate poisoning.	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	22-42
33545185-1	2021	Oxime reactivators of acetylcholinesterase (AChE) represent an integral part of standard antidote treatment of organophosphate poisoning.	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	44-48
33540058-12	2021	Collectively, the results of this study suggest that Cl-HIN is an oxime capable of reactivating AChE inhibited and presents na antidepressant-like effect in cases of prolonged exposure to malathion.	Oximes	66-71	acetylcholinesterase	Rattus norvegicus	96-100
33592259-9	2021	Novel oxime 15 demonstrated significant broad spectrum reactivation of OP-inhibited rat serum BChE while novel oxime 20 demonstrated significant broad spectrum reactivation of OP-inhibited human serum BChE.	Oximes	111-116	butyrylcholinesterase	Homo sapiens	201-205
33592259-0	2021	Reactivation of Organophosphate-inhibited Serum Butyrylcholinesterase by Novel Substituted Phenoxyalkyl Pyridinium Oximes and Traditional Oximes.	Oximes	115-121	butyrylcholinesterase	Homo sapiens	48-69
33592259-3	2021	Oximes are a critical piece to the therapeutic regimen which remove the OP from the inhibited AChE and restore normal cholinergic function.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
33592259-9	2021	Novel oxime 15 demonstrated significant broad spectrum reactivation of OP-inhibited rat serum BChE while novel oxime 20 demonstrated significant broad spectrum reactivation of OP-inhibited human serum BChE.	Oximes	6-11	butyrylcholinesterase	Homo sapiens	94-98
33566584-0	2021	Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening.	Oximes	19-24	hexokinase 2	Homo sapiens	45-49
33548273-2	2021	However, available oxime antidote 2-PAM only reactivates OP-inhibited AChE in peripheral tissues.	Oximes	19-24	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	36-39
33548273-2	2021	However, available oxime antidote 2-PAM only reactivates OP-inhibited AChE in peripheral tissues.	Oximes	19-24	acetylcholinesterase	Cavia porcellus	70-74
33548273-3	2021	Monoisonitrosoacetone (MINA), a tertiary oxime, reportedly reactivates AChE in the central nervous system (CNS).	Oximes	41-46	acetylcholinesterase	Cavia porcellus	71-75
33682265-10	2021	Compared with 2-PAM, Oxime 20 stimulated Bcl2l1 expression more and returned expression closer to the vehicle control values.	Oximes	21-26	Bcl2-like 1	Rattus norvegicus	41-47
33592259-10	2021	All tested oximes were poor reactivators of OP-inhibited guinea pig serum BChE.	Oximes	11-17	butyrylcholinesterase	Homo sapiens	74-78
33672922-5	2021	Furthermore, species-specific amino acid differences in acetylcholinesterase confound studies that use oximes or other compounds to restore its function after inhibition by CWNA.	Oximes	103-109	acetylcholinesterase	Mus musculus	56-76
33135362-0	2021	MS-based screening of small amino acid derived oxime libraries for hGAT3 inhibitors.	Oximes	47-52	solute carrier family 6 member 11	Homo sapiens	67-72
33135362-1	2021	Aiming at the identification of new hGAT3 inhibitors, oxime libraries comprising a total of more than 1100 compounds were generated by reaction of various aldehyde and ketone libraries with hydroxylamines that comprised isoserine, 4-amino-2-hydroxybutyric acid, 4-amino-3-hydroxybutyric or nipecotic acid subunits.	Oximes	54-59	solute carrier family 6 member 11	Homo sapiens	36-41
33135362-2	2021	The formed oxime libraries were tested for their inhibitory potency at hGAT3 using an MS transporter assay.	Oximes	11-16	solute carrier family 6 member 11	Homo sapiens	71-76
33135362-5	2021	1-[2-({[bis(4-chlorophenyl)methylene]amino}oxy)ethyl]piperidine-3-carboxylic acid was found to be the most potent compound of tested oxime (pIC 50  = 5.17 +- 0.12) displaying an inhibitory potency close to the potency of the enantiopure benchmark hGAT3 inhibitor ( S )-SNAP-5114.	Oximes	133-138	solute carrier family 6 member 11	Homo sapiens	247-252
33563155-15	2022	The binding of oximes with bovine serum albumin (BSA) revealed static quenching of intrinsic fluorescence of BSA by oxime.	Oximes	15-21	albumin	Homo sapiens	34-47
33563155-15	2022	The binding of oximes with bovine serum albumin (BSA) revealed static quenching of intrinsic fluorescence of BSA by oxime.	Oximes	15-20	albumin	Homo sapiens	34-47
33223264-0	2021	Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable "click" oxime bond tethers and preclinical evaluation against prostate cancer.	Oximes	91-96	gonadotropin releasing hormone 1	Mus musculus	40-44
33681810-2	2020	Four sugars, sialic acid, and the dimer through tetramer of alpha-2 8-linked oligosialic acid were added to an aminooxy-terminated hexavalent dendrimer core using a chemoselective oxime-forming reaction.	Oximes	180-185	glycoprotein hormone subunit alpha 2	Homo sapiens	60-67
33563155-11	2022	The binding of oximes with bovine serum albumin (BSA) was also investigated by UV-Vis spectrophotometer.	Oximes	15-21	albumin	Homo sapiens	34-47
33563155-14	2022	Further, in-vitro enzymatic assay indicated reasonable reactivation potential of the oximes against paraoxon-inhibited AChE.	Oximes	85-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
33257873-3	2021	This phosphorylation is a unique cryptic modification as it is introduced in the third of seven steps during aminohexuronic acid (AHA) nucleoside biosynthesis, retained throughout the pathway"s duration, and is removed in the last step of the pathway.	Oximes	130-133	cripto, FRL-1, cryptic family 1	Homo sapiens	33-40
32334495-3	2021	When AChE is inhibited by OPs, its reactivation can be usually performed through cationic oximes.	Oximes	90-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	5-9
33213094-2	2020	The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current emergency treatment including anticholinergics, benzodiazepines, and oxime reactivators.	Oximes	191-196	acetylcholinesterase	Danio rerio	87-107
33213094-7	2020	Additionally, the organophosphorus-specific response for oxime reactivation of acetylcholinesterase was comparable to what has been previously reported.	Oximes	57-62	acetylcholinesterase	Danio rerio	79-99
32896797-0	2020	Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1.	Oximes	154-159	solute carrier family 6 member 1	Homo sapiens	192-210
32896797-2	2020	After reaction of a nipecotic acid derivative possessing a hydroxylamine functionality with aldehydes, the resulting oxime library was screened accordingly toward the GABA transporter subtype 1 (GAT1), a drug target for several neurological disorders.	Oximes	117-122	solute carrier family 6 member 1	Homo sapiens	167-193
32896797-2	2020	After reaction of a nipecotic acid derivative possessing a hydroxylamine functionality with aldehydes, the resulting oxime library was screened accordingly toward the GABA transporter subtype 1 (GAT1), a drug target for several neurological disorders.	Oximes	117-122	solute carrier family 6 member 1	Homo sapiens	195-199
32198755-6	2020	Therapeutic guidance concerning the duration and success of the current oxime therapy via determination of the cholinesterase status can contribute to an optimal use of resources.	Oximes	72-77	butyrylcholinesterase	Homo sapiens	111-125
32319115-1	2020	Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	131-151
32319115-1	2020	Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	153-157
32319115-2	2020	Oximes, such as the pyridinium oxime pralidoxime (2-PAM) in the United States, can reactivate the inhibited AChE and restore cholinergic function.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	108-112
32319115-5	2020	Using high sublethal dosages of the OPs, the novel oximes were observed to attenuate seizure-like behavior in rats and to reduce the levels of glial fibrillary acidic protein (an indicator of glial scarring) to control levels, in contrast to levels observed with 2-PAM or no oxime therapy.	Oximes	51-57	glial fibrillary acidic protein	Rattus norvegicus	143-174
32319115-5	2020	Using high sublethal dosages of the OPs, the novel oximes were observed to attenuate seizure-like behavior in rats and to reduce the levels of glial fibrillary acidic protein (an indicator of glial scarring) to control levels, in contrast to levels observed with 2-PAM or no oxime therapy.	Oximes	51-56	glial fibrillary acidic protein	Rattus norvegicus	143-174
32436233-1	2020	Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE).	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	53-73
32436233-1	2020	Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE).	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	75-79
32436233-2	2020	Although they share a common mechanism of AChE reactivation, the rate and amount of oxime that enters the brain are critical to the efficacy, a process linked to the oxime structure and charge.	Oximes	84-89	acetylcholinesterase	Rattus norvegicus	42-46
32436233-2	2020	Although they share a common mechanism of AChE reactivation, the rate and amount of oxime that enters the brain are critical to the efficacy, a process linked to the oxime structure and charge.	Oximes	166-171	acetylcholinesterase	Rattus norvegicus	42-46
32544483-0	2020	Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
33105595-4	2020	Interestingly, its analogue, an oxime ether with a benzobicyclo[3.2.1]-skeleton, compound 32 was one of the most potent BChE inhibitors in this study (IC50 = 31 microM), but not as potent as endo-43, an ether derivative of the benzobicyclo[3.2.1]octene with an additional phenyl substituent (IC50 = 17 microM).	Oximes	32-37	butyrylcholinesterase	Homo sapiens	120-124
32835730-0	2020	Effect of P-glycoprotein on the availability of oxime reactivators in the brain.	Oximes	48-53	ATP binding cassette subfamily B member 1	Homo sapiens	10-24
32835730-6	2020	A major drawback of currently available oxime reactivators is their inability to reactivate AChE in the central nervous system (CNS) as they are unable to cross the blood-brain barrier.	Oximes	40-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96
32835730-8	2020	The aim of this study was to evaluate the effect of P-gp on the permeation of oximes into the brain.	Oximes	78-84	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
32544483-0	2020	Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.	Oximes	112-118	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
32786529-5	2020	The activity of the BChE-polymer-oxime conjugates was dependent on the degree of oxime loading within the copolymer side chains.	Oximes	33-38	butyrylcholinesterase	Homo sapiens	20-24
32786529-6	2020	The covalent modification of oxime-containing copolymers prolonged the activity of BChE in the presence of the VX- and cyclosarin-fluorogenic analogues EMP-MeCyC and CMP-MeCyC, respectively.	Oximes	29-34	butyrylcholinesterase	Homo sapiens	83-87
32502538-2	2020	Atropine-oximes therapy is commonly used; however, the efficacy of oximes in the reactivation of AChE has been inconsistent.	Oximes	67-73	acetylcholinesterase	Rattus norvegicus	97-101
32899591-7	2020	Comparing theoretical and experimental data, it is possible to notice that the oxime, in most cases, showed better reactivation percentages at higher concentrations, with the best result for the reactivation of the AChE-VX adduct.	Oximes	79-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	215-219
32583098-5	2020	Furthermore, this oxime in combination with BChE exhibited a capability to act as a bioscavenger of cyclosarin, degrading within 2 h up to 100-fold excess of cyclosarin concentration over the enzyme.	Oximes	18-23	butyrylcholinesterase	Homo sapiens	44-48
32583098-6	2020	Molecular modeling revealed that the position of the cyclohexyl moiety conjugated with the active site serine of BChE directs the favorable positioning of the quinuclidinium ring and the bromophenyl moiety of Q8, which makes phosphonylated-serine easily accessible for the nucleophilic displacement by the oxime group of Q8.	Oximes	306-311	butyrylcholinesterase	Homo sapiens	113-117
32388435-0	2020	Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates.	Oximes	66-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-109
32388435-4	2020	It was also found that some non-oxime derivatives of Mannich phenols displayed obvious reactivation potency for VX, sarin and pesticides inhibited hAChE even in very low concentration.	Oximes	32-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-152
32267631-1	2020	Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.	Oximes	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	27-30
32267631-1	2020	Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-148
32267631-1	2020	Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
32639532-3	2020	The crystal structure was determined for the complex of oxime III within human BChE, confirming that all three binding groups interacted with active site residues.	Oximes	56-61	butyrylcholinesterase	Homo sapiens	79-83
32639532-4	2020	In the case of BChE inhibited by GF, oximes I (kr = 207 M-1 min-1) and III (kr = 213 M-1 min-1) showed better reactivation efficiency than the reference oxime 2-PAM.	Oximes	37-43	butyrylcholinesterase	Homo sapiens	15-19
32639532-5	2020	Finally, the key mechanistic steps in the reactivation of GF-inhibited BChE with oxime III were modelled using the PM7R6 method, stressing the importance of proton transfer from Nepsilon of His438 to Ogamma of Ser203 for achieving successful reactivation.	Oximes	81-86	butyrylcholinesterase	Homo sapiens	71-75
32454005-0	2020	Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase.	Oximes	47-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
32454005-1	2020	Since several decades oximes have been used as part of treatment of nerve agent intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase after its covalent inhibition by organophosphorus compounds such as pesticides and nerve agents.	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-175
32388435-1	2020	A new series of novel nonquaternary conjugates and non-oxime reactivators for reactivation of both nerve agents and pesticides inhibited hAChE were described in this paper.	Oximes	55-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-142
31954867-3	2020	Three common oximes are available: HI-6, Pralidoxime (2-PAM) and Obidoxime (Obi), all possess a nucleophile that can break the NA-AChE covalent bond.	Oximes	13-19	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	56-59
32512884-2	2020	One therapeutic approach is the reactivation of inhibited acetylcholinesterase by oximes.	Oximes	82-88	acetylcholinesterase	Mus musculus	58-78
32333945-0	2020	Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants.	Oximes	44-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
32333945-5	2020	Therefore, this review focuses on oxime-assisted catalysis by AChE mutants that provides a potential means for degradation of organophosphates in the plasma before reaching the cellular target site.	Oximes	34-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
32437172-7	2020	At low molar ratios (1 U:1 AAO/BAO and 1 U:2 AAO/BAO) the dominant species is the uranyl coordinated via the eta1-oxygen atom of the oxime group, while at high molar ratios (1 U:3 AAO/BAO and 1 U:4 AAO/BAO) the dominant species are a tetrameric uranyl-mu3-O-eta1-amidoxime complex similar to compounds 5 and 6 and a uranyl-eta2-amidoxime complex similar to compounds 3 and 4.	Oximes	133-138	secreted phosphoprotein 1	Homo sapiens	109-113
31954867-3	2020	Three common oximes are available: HI-6, Pralidoxime (2-PAM) and Obidoxime (Obi), all possess a nucleophile that can break the NA-AChE covalent bond.	Oximes	13-19	acetylcholinesterase	Cavia porcellus	130-134
32380126-3	2020	Oximes reactivate AChE in both the peripheral nervous system and the CNS.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
31694074-2	2020	Although inconsistent, the standard treatment consists of a muscarinic receptor antagonist (atropine) and AChE-reactivating molecules such as oximes.	Oximes	142-148	acetylcholinesterase	Rattus norvegicus	106-110
32281011-5	2020	RESULTS: We found the activity of caspases and serum MDA and TAC were significantly increased after OP poisoning and decreased after the appropriate atropine and oxime treatment course.	Oximes	162-167	caspase 9	Homo sapiens	34-42
32105443-2	2020	Oxime reactivators of AChE are used in medical practice in the treatment of nerve agent poisoning, but the search for novel improved reactivators with central activity is an ongoing pursuit.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
32086265-5	2020	However, in most clinics only determination of plasma butyrylcholinesterase (BChE) is established which lacks a pathophysiological correlate, shows higher variability in the population and behaves different regarding inhibition by OP and reactivation by oximes.	Oximes	254-260	butyrylcholinesterase	Homo sapiens	77-81
32086265-6	2020	The ChE test kit helped to diagnose atypical cases of OP poisoning, for example, missing of typical muscarinic symptoms, and resulted in administration of pralidoxime, the oxime used in Serbia.	Oximes	161-166	butyrylcholinesterase	Homo sapiens	4-7
32086265-7	2020	The ChE test kit also allows an initial assessment whether an oxime therapy is successful.	Oximes	62-67	butyrylcholinesterase	Homo sapiens	4-7
32086265-8	2020	In one case report, AChE activity increased after oxime administration indicating therapeutic success whereas BChE activity did not.	Oximes	50-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
31830555-2	2020	Current post-exposure nerve agent treatment includes atropine to treat overstimulation at muscarinic synapses, a benzodiazepine anti-convulsant, and an oxime to restore the function of AChE.	Oximes	152-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	185-189
32236245-1	2020	A near-IR perylene diimide probe (OPR-PDI) containing an oxime-propargyl hybrid moiety at the bay position, was designed and synthesized for detection of Pd species and Cu2+ ions in 90% water, the solid state and MG-63 live cells.	Oximes	57-62	peptidyl arginine deiminase 1	Homo sapiens	38-41
32019865-0	2020	Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.	Oximes	64-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-139
32019865-5	2020	On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE (hAChE), here we created seven uncharged acetamido bis-oximes as candidate antidotes.	Oximes	199-219	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
32175496-0	2020	Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
32178264-4	2020	Within the most outstanding reactivators, the substances denominated oximes stand out, showing good performance for reactivating AChE and restoring the normal synaptic acetylcholine (ACh) levels.	Oximes	69-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
31971800-0	2020	O-Perfluoropyridin-4-yl Oximes: Iminyl Radical Precursors for Photo- or Thermal-Induced N-O Cleavage in C(sp2)-C(sp3) Bond Formation.	Oximes	0-30	Sp2 transcription factor	Homo sapiens	104-109
31971800-2	2020	A range of O-perfluoropyridin-4-yl oximes were successfully utilized in C(sp2)-C(sp3) bond formations of quinoxalin-2(1H)-ones and alkenes, providing facile accesses to a range of functionalized alkylnitriles.	Oximes	11-41	Sp2 transcription factor	Homo sapiens	72-77
31999451-0	2020	Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.	Oximes	13-48	signal transducer and activator of transcription 3	Homo sapiens	182-232
31999451-2	2020	In the present study, a set of naphthoquinone aromatic amide-oxime derivatives were designed, which stimulated the immune response via IDO1 inhibition and simultaneously displayed powerful antitumor activity against three selected cancer cell lines through suppressing STAT3 signaling.	Oximes	31-66	indoleamine 2,3-dioxygenase 1	Homo sapiens	135-139
32175496-3	2020	HI-6 and 2-PAM are cationic oximes proved to be effective for the reactivation of AChE inhibited by the nerve agents VX and sarin (GB).	Oximes	28-34	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	11-14
32175496-3	2020	HI-6 and 2-PAM are cationic oximes proved to be effective for the reactivation of AChE inhibited by the nerve agents VX and sarin (GB).	Oximes	28-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86
32175496-5	2020	Uncharged oximes appear as an interesting alternative to solve this problem, but the development and enhancement of more efficient uncharged oximes capable of reactivating human AChE is still necessary.	Oximes	10-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-182
32175496-5	2020	Uncharged oximes appear as an interesting alternative to solve this problem, but the development and enhancement of more efficient uncharged oximes capable of reactivating human AChE is still necessary.	Oximes	141-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-182
32175496-7	2020	In order to investigate the interaction and behavior of cationic and uncharged oximes, we performed here molecular docking, molecular dynamics simulations, and binding energies calculations of the known cationic oximes HI-6 and 2-PAM plus four uncharged oximes found in the literature, complexed with human AChE (HssACHE) conjugated with the nerve agents VX and GB.	Oximes	79-85	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	230-233
32175496-8	2020	The uncharged oximes showed different behaviors, especially RS194B, which presented stability inside AChE-VX, but presented free binding energy lower than cationic oximes, suggesting that structural alterations could favor its interactions with these complexes.	Oximes	14-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
32175496-9	2020	In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates.	Oximes	234-240	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	24-27
32175496-9	2020	In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates.	Oximes	234-240	acetylcholinesterase (Cartwright blood group)	Homo sapiens	246-250
31784187-3	2020	We designed and synthesized a series of substituted nitric oxide (NO)-releasing quinolone-1,2,4-triazole/oxime hybrids, hypothesizing that the introduction of a STAT3 binding scaffold would augment their cytotoxicity.	Oximes	105-110	signal transducer and activator of transcription 3	Mus musculus	161-166
31999451-2	2020	In the present study, a set of naphthoquinone aromatic amide-oxime derivatives were designed, which stimulated the immune response via IDO1 inhibition and simultaneously displayed powerful antitumor activity against three selected cancer cell lines through suppressing STAT3 signaling.	Oximes	31-66	signal transducer and activator of transcription 3	Homo sapiens	269-274
31158460-0	2020	Novel centrally active oxime reactivators of acetylcholinesterase inhibited by surrogates of sarin and VX.	Oximes	23-28	acetylcholinesterase	Rattus norvegicus	45-65
31022458-1	2020	There is a unique in vivo interplay involving the mechanism of inactivation of acetylcholinesterase (AChE) by toxic organophosphorus (OP) compounds and the restoration of AChE activity by oxime antidotes.	Oximes	188-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
31022458-2	2020	OP compounds form covalent adducts to this critical enzyme target and oximes are introduced to directly displace the OP from AChE.	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129
31586705-0	2019	Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-kappaB-mediated transcription in HepG2 hepatoma cells.	Oximes	0-20	nuclear factor kappa B subunit 1	Homo sapiens	80-89
31586705-1	2019	The aim of this study was to evaluate the effect of new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) on the expression and activation of NF-kappaB in human hepatoma HepG2 cells.	Oximes	56-76	nuclear factor kappa B subunit 1	Homo sapiens	171-180
31586705-1	2019	The aim of this study was to evaluate the effect of new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) on the expression and activation of NF-kappaB in human hepatoma HepG2 cells.	Oximes	78-81	nuclear factor kappa B subunit 1	Homo sapiens	171-180
31586705-3	2019	Moreover, conjugation of OAO with ASP led to enhanced downregulation of NF-kappaB expression and activation.	Oximes	25-28	nuclear factor kappa B subunit 1	Homo sapiens	72-81
31586705-6	2019	The results of this study indicate that the new derivatives of OAO and particularly their conjugates with ASP, downregulate the expression of COX-2 in HepG2 cells by modulating the NF-kappaB signaling pathway and suggest their potential application in the prevention of liver inflammation and cancer.	Oximes	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
31586705-6	2019	The results of this study indicate that the new derivatives of OAO and particularly their conjugates with ASP, downregulate the expression of COX-2 in HepG2 cells by modulating the NF-kappaB signaling pathway and suggest their potential application in the prevention of liver inflammation and cancer.	Oximes	63-66	nuclear factor kappa B subunit 1	Homo sapiens	181-190
31521263-2	2019	Herein, a synergetic targeted combination chemotherapy of doxorubicin (DOX) and cisplatin in breast cancer was realized by HER2 antibody-decorated nanoparticles assembled from aldehyde hyaluronic acid (AHA) and hydroxyethyl chitosan (HECS).	Oximes	202-205	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-127
31074292-3	2019	To investigate these interactions, theoretical results from docking were first compared with experimental data of hybrid 5C, 4-PA, and two commercial oximes, on the reactivation of human AChE (HssAChE) inhibited by VX.	Oximes	150-156	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
31264735-7	2019	The other oximes reduced the RR to 0.13 (obidoxime), 0.20 (K-203), 0.21 (K-74), 0.24 (K-75) and 0.26 (pralidoxime), which were significantly more efficacious than 10-methylacridine (RR = 0.65).	Oximes	10-16	keratin 74	Homo sapiens	73-77
31264735-7	2019	The other oximes reduced the RR to 0.13 (obidoxime), 0.20 (K-203), 0.21 (K-74), 0.24 (K-75) and 0.26 (pralidoxime), which were significantly more efficacious than 10-methylacridine (RR = 0.65).	Oximes	10-16	keratin 75	Homo sapiens	86-90
31549708-1	2019	A tridentate ligand LH3 (C11H13N3O4) comprising o-vanillin, hydrazone and oxime donor groups has been employed to prepare a new class of di- and tetranuclear LnIII complexes.	Oximes	74-79	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	20-23
31414695-4	2019	Here, we report the synthesis and biological evaluation of a novel bimodal oxime conjugate composed of a photosensitizing drug, red-emitting pheophorbide a, and nandrolone (NT), a steroid specifically binding the androgen receptor (AR) commonly overexpressed in various tumors.	Oximes	75-80	androgen receptor	Homo sapiens	213-230
31414695-4	2019	Here, we report the synthesis and biological evaluation of a novel bimodal oxime conjugate composed of a photosensitizing drug, red-emitting pheophorbide a, and nandrolone (NT), a steroid specifically binding the androgen receptor (AR) commonly overexpressed in various tumors.	Oximes	75-80	androgen receptor	Homo sapiens	232-234
31414695-12	2019	The oxime ether bond degradation was assayed in living cells by both real-time microscopy and a steroid receptor reporter assay using AR U-2 OS cells.	Oximes	4-9	androgen receptor	Homo sapiens	134-136
31540034-6	2019	Moreover, for the products containing electron-donating substituents (-CH3, -OCH3), the isomerization from the oxime anti to syn isomer under acidic conditions was discovered.	Oximes	111-116	synemin	Homo sapiens	125-128
31540034-8	2019	From NMR data the syn and anti structures of produced oximes were elucidated.	Oximes	54-60	synemin	Homo sapiens	18-21
31516541-2	2019	In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.	Oximes	52-57	butyrylcholinesterase	Rattus norvegicus	267-281
31516541-2	2019	In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.	Oximes	52-57	butyrylcholinesterase	Rattus norvegicus	283-286
31516541-2	2019	In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.	Oximes	104-109	butyrylcholinesterase	Rattus norvegicus	267-281
31516541-2	2019	In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.	Oximes	104-109	butyrylcholinesterase	Rattus norvegicus	283-286
31516541-7	2019	Results: The OXIME blocked the increase of plasma markers of hepatic function (AST and ALP) and the enzymatic inhibition of catalase and glutathione reductase in the liver of malathion-treated rats.	Oximes	13-18	glutathione-disulfide reductase	Rattus norvegicus	137-158
31276662-0	2019	Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models.	Oximes	34-40	butyrylcholinesterase	Homo sapiens	95-116
31276662-3	2019	Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM).	Oximes	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
31276662-3	2019	Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM).	Oximes	68-74	butyrylcholinesterase	Homo sapiens	156-160
31176713-7	2019	Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature.	Oximes	226-231	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-92
31276662-3	2019	Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM).	Oximes	68-74	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	215-218
31276662-4	2019	In vitro studies showed higher intrinsic toxicities of both oximes than 2-PAM for AChE.	Oximes	60-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86
31176713-7	2019	Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature.	Oximes	226-231	ATPase H+ transporting V1 subunit E1	Homo sapiens	112-115
31207225-0	2019	Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects.	Oximes	34-40	acetylcholinesterase	Mus musculus	128-132
31176713-7	2019	Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature.	Oximes	338-343	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-92
31207225-3	2019	Theoretical calculations were performed to assess the difference for the oxime activity with inhibited AChE-complexes and the factors that govern this difference.	Oximes	73-78	acetylcholinesterase	Mus musculus	103-107
31176713-7	2019	Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature.	Oximes	338-343	ATPase H+ transporting V1 subunit E1	Homo sapiens	112-115
31138650-0	2019	Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.	Oximes	36-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	133-153
31138650-4	2019	Current antidotes, including oxime reactivators that attack the OP-AChE conjugate to free the active enzyme, are inefficient.	Oximes	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
31138650-6	2019	Here, we present room temperature X-ray structures of native and VX-phosphonylated hAChE with an imidazole-based oxime reactivator, RS-170B.	Oximes	113-118	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-88
31097402-0	2019	Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1).	Oximes	30-35	solute carrier family 6 member 1	Homo sapiens	167-204
31097402-0	2019	Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1).	Oximes	30-35	solute carrier family 6 member 1	Homo sapiens	206-210
31097402-1	2019	In the present study, the concept of oxime library screening by MS Binding Assays was successfully extended to N-substituted lipophilic pyrrolidine-3-carboxylic acid derivatives in the pursuit of varying the amino acid motif in order to identify new inhibitors for GAT1 and to broaden structure-activity-relationships for this target, the most abundant GABA transporter in the central nervous system.	Oximes	37-42	solute carrier family 6 member 1	Homo sapiens	265-269
31097402-5	2019	Thereby, oxime derivatives with a 1,1"-biphenyl moiety were found as the first inhibitors of mGAT1 comprising a pyrrolidine-3-carboxylic acid motif with affinities in the submicromolar range.	Oximes	9-14	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	93-98
31004594-3	2019	Its BChE reactivation potency was showed to be promising when compared to the standard oximes used in medical practice, asoxime (HI-6) and pralidoxime (2-PAM), especially in case of sarin and tabun.	Oximes	87-93	butyrylcholinesterase	Homo sapiens	4-8
29722548-4	2019	To determine if P-gp affinity screening could be used to reduce animal use, we measured in vitro oxime-stimulated ATPase activity to see if the in vivo reactivation efficacies related to the oximes" functions as P-gp substrates.	Oximes	191-197	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	16-20
29722548-4	2019	To determine if P-gp affinity screening could be used to reduce animal use, we measured in vitro oxime-stimulated ATPase activity to see if the in vivo reactivation efficacies related to the oximes" functions as P-gp substrates.	Oximes	191-197	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	212-216
29722548-5	2019	High efficacy oximes were expected to be poor P-gp substrates, thus remaining in the brain longer.	Oximes	14-20	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	46-50
29722548-6	2019	The high efficacy oximes (24-35% brain AChE reactivation) were worse P-gp substrates than the low efficacy oximes (0-7% brain AChE reactivation).	Oximes	18-24	acetylcholinesterase	Rattus norvegicus	39-43
29722548-6	2019	The high efficacy oximes (24-35% brain AChE reactivation) were worse P-gp substrates than the low efficacy oximes (0-7% brain AChE reactivation).	Oximes	18-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	69-73
29722548-6	2019	The high efficacy oximes (24-35% brain AChE reactivation) were worse P-gp substrates than the low efficacy oximes (0-7% brain AChE reactivation).	Oximes	18-24	acetylcholinesterase	Rattus norvegicus	126-130
29722548-7	2019	However, the oxime group with medium in vivo reactivation of 10-17% were even worse P-gp substrates than the high efficacy group so their reactivation ability was not reflected by P-gp export.	Oximes	13-18	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-88
29722548-8	2019	The results suggest that in vitro P-gp ATPase activity can remove the low efficacy oximes from in vivo testing, but is not sufficient to differentiate between the top two tiers.	Oximes	83-89	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	34-38
31112674-5	2019	The central compartment is readily accessible by the OPs which are lipophilic bullets that can easily cross the BBB, whereas first-line therapeutics, namely oxime-based AChE reactivators and atropine, do not cross or do so rather slowly.	Oximes	157-162	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
31112674-6	2019	The limitation of oxime-based AChE reactivators can be ascribed to their chemical nature, bearing a positive charge which is essential either for their AChE affinity or their reactivating potency.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
31112674-6	2019	The limitation of oxime-based AChE reactivators can be ascribed to their chemical nature, bearing a positive charge which is essential either for their AChE affinity or their reactivating potency.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-156
30858091-12	2019	However, the oxime HI-6 as potent reactivator of cyclosarin-inhibited AChE was not able to prevent the FPDc prolongation in this model.	Oximes	13-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
31136186-2	2019	Under visible-light irradiation, single-electron transfer from fac-Ir(ppy)3 to related oxime takes place followed by a fast beta-fragment of C-C bond to yield aryl and aliphatic acyl radicals, subsequently captured by diverse Michael acceptors.	Oximes	87-92	FA complementation group C	Homo sapiens	63-66
30950246-3	2019	The current antidotes are oxime-based drugs that can regenerate the AChE catalytic activity.	Oximes	26-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30978400-2	2019	Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhibited AChE, but the classical oximes are particularly ineffective in counteracting tabun exposure.	Oximes	128-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-163
30978400-3	2019	In a recent publication (Kovarik et al., 2019), we showed that several oximes prepared by the Huisgen 1,3 dipolar cycloaddition and related precursors efficiently reactivate the tabun-AChE conjugate.	Oximes	71-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-188
30978400-7	2019	Indeed, after initial screening of the triazole oxime library and its precursors for the reactivation efficacy on Y337A and Y337A/F338A human AChE mutants, we found potentially active oxime-mutant enzyme pairs capable of degrading tabun in cycles of inhibition and reactivation.	Oximes	48-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
30444932-5	2019	Oxime nucleophiles can reactivate select OP-inhibited acetylcholinesterase (AChE).	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-74
30444932-5	2019	Oxime nucleophiles can reactivate select OP-inhibited acetylcholinesterase (AChE).	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
30777661-1	2019	Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS.	Oximes	28-33	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	162-167
30777661-2	2019	By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed.	Oximes	32-37	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	72-77
30777661-3	2019	In the present study, oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1.	Oximes	22-27	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	251-256
30682493-0	2019	Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro.	Oximes	28-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
30500087-0	2019	Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase-3 activation activities.	Oximes	46-52	caspase 3	Homo sapiens	115-124
30458057-0	2019	Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.	Oximes	59-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-109
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Oximes	211-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Oximes	211-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
30458057-5	2019	We identified several oximes with significantly improved in vitro reactivating potential for tabun-inhibited human AChE, and in vivo antidotal efficacies in tabun-exposed mice.	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
30347329-5	2019	Molecular modeling suggested a mode of binding interaction at the JNK catalytic site and that the selected oxime derivatives were potentially competitive JNK inhibitors.	Oximes	107-112	mitogen-activated protein kinase 8	Homo sapiens	66-69
30347329-5	2019	Molecular modeling suggested a mode of binding interaction at the JNK catalytic site and that the selected oxime derivatives were potentially competitive JNK inhibitors.	Oximes	107-112	mitogen-activated protein kinase 8	Homo sapiens	154-157
30347329-7	2019	Thus, oximes with indenoquinoxaline and tryptanthrin nuclei can serve as specific small-molecule modulators for mechanistic studies of JNK, as well as potential leads for the development of anti-inflammatory drugs.	Oximes	6-12	mitogen-activated protein kinase 8	Homo sapiens	135-138
30312685-0	2018	Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.	Oximes	123-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	21-41
30362667-1	2018	The current standard therapy to counteract organophosphate intoxication is not effective in equal measure against all types of organophosphorus compounds (OPCs), as the outcome of oxime-induced reactivation of inactivated acetylcholinesterase (AChE) strongly depends on the particular OPC.	Oximes	180-185	acetylcholinesterase (Cartwright blood group)	Homo sapiens	222-242
30362667-1	2018	The current standard therapy to counteract organophosphate intoxication is not effective in equal measure against all types of organophosphorus compounds (OPCs), as the outcome of oxime-induced reactivation of inactivated acetylcholinesterase (AChE) strongly depends on the particular OPC.	Oximes	180-185	acetylcholinesterase (Cartwright blood group)	Homo sapiens	244-248
30312685-2	2018	Insufficient efficacy of the standard therapy with atropine and AChE reactivators (oximes) against certain OP initiated synthesis of novel non-oxime reactivators basing on the common structure 4-amino-2-((diethylamino)methyl)phenol (ADOC).	Oximes	83-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
30312685-2	2018	Insufficient efficacy of the standard therapy with atropine and AChE reactivators (oximes) against certain OP initiated synthesis of novel non-oxime reactivators basing on the common structure 4-amino-2-((diethylamino)methyl)phenol (ADOC).	Oximes	83-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
30485691-1	2018	In this study, pyrrolidine-3-acetic acid derived oxime libraries were applied to the concept of library screening by MS Binding Assays, as a powerful technique to reveal new potent murine gamma-aminobutyric acid transporter subtype (mGAT1) inhibitors.	Oximes	49-54	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	233-238
30485691-3	2018	The oxime libraries have been screened by means of competitive MS Binding Assays and, as a consequence, the most active libraries were further investigated through deconvolution experiments to identify single oximes responsible for the observed activity on the target mGAT1.	Oximes	4-9	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	268-273
30485691-3	2018	The oxime libraries have been screened by means of competitive MS Binding Assays and, as a consequence, the most active libraries were further investigated through deconvolution experiments to identify single oximes responsible for the observed activity on the target mGAT1.	Oximes	209-215	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	268-273
30218682-4	2018	HI-6 dimethanesulfonate (HI-6 DMS) is an oxime able to reactivate in vitro and in vivo VR-inhibited AChE.	Oximes	41-46	acetylcholinesterase	Macaca fascicularis	100-104
30265992-3	2018	The in vitro reactivation experiment for pesticides inhibited hAChE of these new synthesized oximes were conducted for the first time.	Oximes	93-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-67
30265992-5	2018	It was found that introduction of peripheral site ligands could increase oximes" binding affinity for inhibited hAChE in most cases, which resulted in greater reactivation ability.	Oximes	73-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-117
30424582-0	2018	Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110
30496567-7	2018	However, the rats challenged with NIMP or NEMP plus therapy with our novel Oxime 20 (either a bromide or a mesylate salt) showed GFAP levels statistically undistinguishable from controls.	Oximes	75-80	glial fibrillary acidic protein	Rattus norvegicus	129-133
30176309-8	2018	Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mumol/kg in contrast to BMD58-K203 = 100 mumol/kg.	Oximes	0-5	Bone mineral density QTL 58	Rattus norvegicus	123-128
30176309-8	2018	Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mumol/kg in contrast to BMD58-K203 = 100 mumol/kg.	Oximes	0-5	Bone mineral density QTL 58	Rattus norvegicus	163-168
30122284-0	2018	Oximes short-acting CB1 receptor agonists.	Oximes	0-6	cannabinoid receptor 1	Homo sapiens	20-23
30374056-0	2018	Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.	Oximes	15-21	dynactin subunit 6	Homo sapiens	94-97
30374056-0	2018	Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.	Oximes	15-21	cyclin D1	Homo sapiens	120-129
30064081-5	2018	The new zinc-binders, both of the oxime and sulfonamide types, showed a striking selective activity against the target hCA IX over ubiquitous hCA I and II, with diverse inhibitory ranges and ratio differing the two subsets.	Oximes	34-39	HCA1	Homo sapiens	119-122
30064081-5	2018	The new zinc-binders, both of the oxime and sulfonamide types, showed a striking selective activity against the target hCA IX over ubiquitous hCA I and II, with diverse inhibitory ranges and ratio differing the two subsets.	Oximes	34-39	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	142-154
30122284-1	2018	New oximes short-acting CB1 agonists were explored by the introduction of an internal oxime and polar groups at the C3 alkyl tail of Delta8-THC.	Oximes	4-10	cannabinoid receptor 1	Homo sapiens	24-27
30122284-1	2018	New oximes short-acting CB1 agonists were explored by the introduction of an internal oxime and polar groups at the C3 alkyl tail of Delta8-THC.	Oximes	4-9	cannabinoid receptor 1	Homo sapiens	24-27
30122284-4	2018	All oxime analogs showed comparable affinity at the CB2 receptor, but surprisingly they were found to function as inverse agonists for CB2.	Oximes	4-9	cannabinoid receptor 2	Homo sapiens	52-55
30122284-4	2018	All oxime analogs showed comparable affinity at the CB2 receptor, but surprisingly they were found to function as inverse agonists for CB2.	Oximes	4-9	cannabinoid receptor 2	Homo sapiens	135-138
30122284-9	2018	We have selected oxime trans-8a based on its potency for CB1, and favorable pharmacodynamic profile, such as fast onset and predictable duration of pharmacological action, for evaluation in pre-clinical models of anorexia nervosa.	Oximes	17-22	cannabinoid receptor 1	Homo sapiens	57-60
30125110-3	2018	A promising reactivator based on tetrahydroacridine linked to a nonquaternary oxime is also an undesired submicromolar reversible inhibitor of AChE.	Oximes	78-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
30056178-6	2018	2-PAM Cl is the U.S. FDA-approved standard-of-care oxime therapy for OP intoxication.	Oximes	51-56	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	2-5
30167602-4	2018	Here we report a stable Abeta oligomer mimic that is transformed into fibrils by a chemical stimulus, i.e., an oxime exchange reaction.	Oximes	111-116	amyloid beta precursor protein	Homo sapiens	24-29
30096649-0	2018	Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase.	Oximes	26-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
30096649-3	2018	The presently fielded oximes reactivate OP-inhibited AChE by liberating the phosphylated serine.	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
30096649-6	2018	Recently, a number of non-oxime compounds was discovered in which the 4-amino-2-((diethylamino)methyl)phenol (ADOC) motif proved to be able to reactivate OP-inhibited AChE to some extent.	Oximes	26-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171
30096649-8	2018	We here disclose that one of those compounds showed a remarkable ability to reactivate OP-inhibited hAChE in vitro and that it is the most potent non-oxime reported to date.	Oximes	150-155	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-105
30056178-12	2018	Furthermore, based on those ED50s, the TI trend of the various oximes against both GB and VX was MMB4 DMS &gt; HLo-7 DMS &gt; 2-PAM Cl, while against PHO, MMB4 DMS &gt; 2-PAM Cl &gt; HLo-7 DMS.	Oximes	63-69	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	128-131
30056178-12	2018	Furthermore, based on those ED50s, the TI trend of the various oximes against both GB and VX was MMB4 DMS &gt; HLo-7 DMS &gt; 2-PAM Cl, while against PHO, MMB4 DMS &gt; 2-PAM Cl &gt; HLo-7 DMS.	Oximes	63-69	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	171-174
30110162-3	2018	Phosphylation of acetylcholinesterase produces two adducts, an initial neutral adduct that can be reactivated with oxime nucleophiles, and a subsequent monoanionic adduct (called aged acetylcholinesterase) which has proven over two generations to be impervious to reactivation.	Oximes	115-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	17-37
28993240-1	2018	Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes.	Oximes	192-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
28993240-1	2018	Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes.	Oximes	192-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
28993240-7	2018	In conclusion, the results of the present study indicate a negligible reactivation of soman-inhibited AChE by oximes at conditions simulating the in vivo poisoning by soman.	Oximes	110-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-106
29129798-1	2018	Post-exposure nerve agent treatment usually includes administration of an oxime, which acts to restore function of the enzyme acetylcholinesterase (AChE).	Oximes	74-79	acetylcholinesterase	Cavia porcellus	126-146
29129798-1	2018	Post-exposure nerve agent treatment usually includes administration of an oxime, which acts to restore function of the enzyme acetylcholinesterase (AChE).	Oximes	74-79	acetylcholinesterase	Cavia porcellus	148-152
29129798-4	2018	As such, there is a need to understand the relationship between dose rate, plasma concentration, reactivation of AChE activity and efficacy, to provide supporting evidence for oxime infusions in nerve agent poisoning.	Oximes	176-181	acetylcholinesterase	Cavia porcellus	113-117
29180286-0	2018	The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110
29180286-3	2018	The endeavor of many chemists to find more efficient reactivators resulted in thousands of newly-designed and synthesized oximes-potential reactivators of AChE.	Oximes	122-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
30176331-14	2018	The oxime acts as antidote against physostigmine and pyridostigmine poisoning by reactivating AChE in the brain and diaphragm, respectively.	Oximes	4-9	acetylcholinesterase	Rattus norvegicus	94-98
29626600-0	2018	Oxime-functionalized cryogel disks for catalase immobilization.	Oximes	0-5	catalase	Homo sapiens	39-47
29772260-0	2018	Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67
29772260-1	2018	The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents.	Oximes	26-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-98
29772260-1	2018	The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents.	Oximes	26-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104
29626600-2	2018	In the current study, catalase immobilization was applied onto the oxime-functionalized cryogel disks.	Oximes	67-72	catalase	Homo sapiens	22-30
29626600-10	2018	Furthermore, catalase desorption was achieved by 1.0M NaSCN at pH8.0 successfully and catalase adsorption capacity of oxime-functionalized cryogel disk was decreased by 9.9% at the end of 5 adsorption-desorption cycle.	Oximes	118-123	catalase	Homo sapiens	13-21
29626600-10	2018	Furthermore, catalase desorption was achieved by 1.0M NaSCN at pH8.0 successfully and catalase adsorption capacity of oxime-functionalized cryogel disk was decreased by 9.9% at the end of 5 adsorption-desorption cycle.	Oximes	118-123	catalase	Homo sapiens	86-94
29614332-3	2018	Treatment for toxicity due to OPC exposure has been largely focused on the reactivation of AChE by oxime-based compounds via direct nucleophilic attack on the phosphorous center.	Oximes	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
29980922-0	2018	Influence of gauche effect on uncharged oxime reactivators for the reactivation of tabun-inhibited AChE: quantum chemical and steered molecular dynamics studies.	Oximes	40-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
29980922-1	2018	The neutral oxime reactivator RS194B with a seven-membered ring has shown better efficacy towards the tabun-inhibited AChE than that of RS69N with a six-membered ring and RS41A with a five-membered ring.	Oximes	12-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122
28446076-2	2018	Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human AChE under some conditions.	Oximes	5-11	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	26-29
29773682-0	2018	Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase.	Oximes	27-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	Oximes	155-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	Oximes	155-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
29920954-4	2018	This reaction was very selective for the syn-oxime.	Oximes	45-50	synemin	Homo sapiens	41-44
29735900-4	2018	Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate).	Oximes	12-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-193
29735900-4	2018	Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate).	Oximes	12-18	butyrylcholinesterase	Homo sapiens	208-212
29735900-4	2018	Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate).	Oximes	12-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-193
29735900-4	2018	Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate).	Oximes	12-17	butyrylcholinesterase	Homo sapiens	208-212
28446076-0	2018	Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach.	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
28446076-2	2018	Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human AChE under some conditions.	Oximes	5-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
29548566-2	2018	In this study, an unusual separation situation in comprehensive two dimensional GC where two dimensional interconversion (i.e. a raised plateau in both first and second dimension, 1D and 2D) was observed in analysis of oxime isomers.	Oximes	219-224	leiomodin 1	Homo sapiens	180-189
29548566-5	2018	The simulated results were supported by experimental results obtained by a comprehensive heart-cut multidimensional GC (H/C MDGC) approach which was developed to clearly investigate isomerisation of E/Z oxime molecules in both 1D and 2D separations under different isothermal conditions.	Oximes	203-208	leiomodin 1	Homo sapiens	227-236
29553731-0	2018	Dynamic Mechanism of a Fluorinated Oxime Reactivator Unbinding from AChE Gorge in Polarizable Water.	Oximes	35-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
29577198-3	2018	Oxime-induced reactivation of acetylcholinesterase was most pronounced in dipyroxime and toxogonin: parameters of the kinetics of reduction of the phosphorylated enzyme differed by more than 2 times from the values received with the use of other reactivators.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
29719573-0	2018	Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin-GnRH-III conjugates developed for targeted drug delivery.	Oximes	49-54	gonadotropin releasing hormone 1	Homo sapiens	80-84
27275644-3	2018	This part is devoted to non-aromatic molecules characterized by a lone pair located on a sp2 nitrogen atom, it embraces functional groups such as imines, amidines, guanidines, diazenes, hydrazines, oximes, and phosphazenes.	Oximes	198-204	Sp2 transcription factor	Homo sapiens	89-92
29482737-0	2018	Kinetic analysis of oxime-assisted reactivation of human, Guinea pig, and rat acetylcholinesterase inhibited by the organophosphorus pesticide metabolite phorate oxon (PHO).	Oximes	20-25	acetylcholinesterase	Rattus norvegicus	78-98
28971759-7	2018	RESULTS: Over the last decades the introduction of oxime groups in the steroid scaffold is originating molecules with relevant antitumor activities, as well as steroid sulfatase, aromatase, 17alpha-hydroxylase-17,20-lyase, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase type 1 inhibitory activities.	Oximes	51-56	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	244-286
28971759-8	2018	As relevant examples, pregnenolone 20-oximes showed high activity as 17alpha-hydroxylase-17,20-lyase and 5alpha-reductase inhibitors and the introduction of an oxime group at C-6 in androstane series also led to relevant results as aromatase inhibitors.	Oximes	38-43	complement C6	Homo sapiens	175-178
29098328-2	2018	On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies.	Oximes	87-93	acetylcholinesterase	Rattus norvegicus	137-141
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Oximes	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
29216560-7	2018	Taken together, these efforts culminated in the discovery of oxime 2a as a potential SGLT2 inhibitor.	Oximes	61-66	solute carrier family 5 member 2	Homo sapiens	85-90
29218520-4	2018	This process started with the identification of a focused series of oxime derivatives, originally designed as estrogen receptor (ER) ligands, which were structurally optimized in order to direct their activity towards GLUT1 and to minimize their binding to the ERs, leading to the production of efficient and selective inhibitors of glucose uptake in cancer cells.	Oximes	68-73	estrogen receptor 1	Homo sapiens	110-127
29218520-4	2018	This process started with the identification of a focused series of oxime derivatives, originally designed as estrogen receptor (ER) ligands, which were structurally optimized in order to direct their activity towards GLUT1 and to minimize their binding to the ERs, leading to the production of efficient and selective inhibitors of glucose uptake in cancer cells.	Oximes	68-73	estrogen receptor 1	Homo sapiens	129-131
29218520-4	2018	This process started with the identification of a focused series of oxime derivatives, originally designed as estrogen receptor (ER) ligands, which were structurally optimized in order to direct their activity towards GLUT1 and to minimize their binding to the ERs, leading to the production of efficient and selective inhibitors of glucose uptake in cancer cells.	Oximes	68-73	solute carrier family 2 member 1	Homo sapiens	218-223
28722512-5	2018	In silico the molecular interactions between AChE and oximes were examined and binding energies were assessed.	Oximes	54-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
28722512-7	2018	In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
29091431-1	2017	Recently, a new class of reactivators of chemical warfare agent inhibited acetylcholinesterase (AChE) with promising in vitro potential was developed by the covalent linkage of an oxime nucleophile and a peripheral site ligand.	Oximes	180-185	acetylcholinesterase	Rattus norvegicus	74-94
29091431-1	2017	Recently, a new class of reactivators of chemical warfare agent inhibited acetylcholinesterase (AChE) with promising in vitro potential was developed by the covalent linkage of an oxime nucleophile and a peripheral site ligand.	Oximes	180-185	acetylcholinesterase	Rattus norvegicus	96-100
31723659-4	2017	Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted.	Oximes	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
31723659-4	2017	Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted.	Oximes	173-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
28738249-0	2017	New 1,3,4-oxadiazole/oxime hybrids: Design, synthesis, anti-inflammatory, COX inhibitory activities and ulcerogenic liability.	Oximes	21-26	cytochrome c oxidase subunit 8A	Homo sapiens	74-77
28738249-1	2017	A series of new 1,3,4-oxadiazole/oxime hybrids were synthesized and designed as potent COX inhibitors.	Oximes	33-38	cytochrome c oxidase subunit 8A	Homo sapiens	87-90
29291440-7	2018	Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function.	Oximes	0-5	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
29291440-7	2018	Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function.	Oximes	0-5	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
29291440-7	2018	Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function.	Oximes	23-28	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
29291440-7	2018	Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function.	Oximes	23-28	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
28722512-7	2018	In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151
29046224-0	2017	Reprint of: Impact of the corrin framework of vitamin B12 on the electrochemical carbon-skeleton rearrangement in comparison to an imine/oxime planar ligand; tuning selectivity in 1,2-migration of a functional group by controlling electrolysis potential.	Oximes	137-142	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	54-57
28639122-7	2017	RESULTS: F-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with [18F]SFB and (2) oxime formation with 4-[18F]fluorobenzaldehyde and [18F]FDG using the respective aminooxy-functionalized lysine residue.	Oximes	187-192	folate hydrolase 1	Homo sapiens	22-26
28440951-8	2017	5- or 5"-Bromo- or phenyl-substituted (but not in combination) inhibitors, having a H-bonded oxime weakly acidic group of a small volume, are optimal candidates for binding hGSTM1-1.	Oximes	93-98	glutathione S-transferase mu 1	Homo sapiens	173-181
28795808-3	2017	In this paper, we describe how the unique features of SNO-OCTs can be employed to modify an oxime-bearing styrene copolymer and introduce an array of polar functionalities into the polymer.	Oximes	92-97	strawberry notch homolog 1	Homo sapiens	54-57
28542985-6	2017	Oximes poorly reactivate AChE inhibited by phosphoramidates.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-29
28805227-5	2017	The resonance effect dominates the electronic effects on the BDEs of oximes, and electron-donating conjugation increases the BDE.	Oximes	69-75	homeobox D13	Homo sapiens	61-64
28646405-0	2017	Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.	Oximes	48-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
28693885-4	2017	The present study utilized a macaque (Ma) model to demonstrate the efficacy of a novel zwitterionic and centrally acting oxime RS194B to reactivate sarin- and paraoxon-inhibited macaque AChE and butyrylcholinesterase (BChE) in vitro and to further assess the capacity of RS194B to effect a reversal of clinical symptoms following sarin inhalation in vivo.	Oximes	121-126	butyrylcholinesterase	Homo sapiens	195-216
28693885-4	2017	The present study utilized a macaque (Ma) model to demonstrate the efficacy of a novel zwitterionic and centrally acting oxime RS194B to reactivate sarin- and paraoxon-inhibited macaque AChE and butyrylcholinesterase (BChE) in vitro and to further assess the capacity of RS194B to effect a reversal of clinical symptoms following sarin inhalation in vivo.	Oximes	121-126	butyrylcholinesterase	Homo sapiens	218-222
29062551-2	2017	Oximes, especially pralidoxime (2-PAM), are widely used as antidotes to treat OP poisoning.	Oximes	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	34-37
28474886-5	2017	"Click SAgA" (cSAgAPLP:LABL) uses hydrolytically stable covalent conjugation chemistry (Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC)) rather than a hydrolyzable oxime bond to attach PLP and LABL to HA.	Oximes	168-173	proteolipid protein 1	Homo sapiens	19-22
28696367-3	2017	The reactivating efficacy of a newly developed oxime K305 is lower compared to the reactivating efficacy of the oxime K203 and trimedoxime while the ability of the oxime K307 to reactivate tabun-inhibited acetylcholinesterase (AChE) in the brain roughly corresponds to the reactivating efficacy of the oxime K203 and it is slightly lower compared to trimedoxime.	Oximes	47-52	acetylcholinesterase	Rattus norvegicus	205-225
28696367-3	2017	The reactivating efficacy of a newly developed oxime K305 is lower compared to the reactivating efficacy of the oxime K203 and trimedoxime while the ability of the oxime K307 to reactivate tabun-inhibited acetylcholinesterase (AChE) in the brain roughly corresponds to the reactivating efficacy of the oxime K203 and it is slightly lower compared to trimedoxime.	Oximes	47-52	acetylcholinesterase	Rattus norvegicus	227-231
29201079-0	2017	Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase.	Oximes	61-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-135
28737687-4	2017	As the results showed, the tested oximes were more efficient in the reactivation of BChE and they reactivated enzyme activity to up to 70% with reactivation rates similar to known pyridinium oximes used as antidotes in medical practice today.	Oximes	34-40	butyrylcholinesterase	Homo sapiens	84-88
28737687-5	2017	Furthermore, the oximes showed selectivity towards binding to the BChE active site and the determined enzyme-oxime dissociation constants supported work on the future development of inhibitors in other targeted studies (e.g., in treatment of neurodegenerative disease).	Oximes	17-23	butyrylcholinesterase	Homo sapiens	66-70
28737687-5	2017	Furthermore, the oximes showed selectivity towards binding to the BChE active site and the determined enzyme-oxime dissociation constants supported work on the future development of inhibitors in other targeted studies (e.g., in treatment of neurodegenerative disease).	Oximes	17-22	butyrylcholinesterase	Homo sapiens	66-70
28696367-1	2017	The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and trimedoxime.	Oximes	35-41	acetylcholinesterase	Rattus norvegicus	125-145
28696367-1	2017	The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and trimedoxime.	Oximes	35-40	acetylcholinesterase	Rattus norvegicus	125-145
27358236-2	2017	One current approach is directed toward synthesizing oximes with high affinity and reactivatability toward butyrylcholinesterase (BChE) in plasma to generate an effective pseudocatalytic scavenger.	Oximes	53-59	butyrylcholinesterase	Homo sapiens	107-128
28412361-5	2017	INCB14943 binds to heme iron in IDO1 protein through the oxime nitrogen.	Oximes	57-62	indoleamine 2,3-dioxygenase 1	Homo sapiens	32-36
28412361-7	2017	Comparing with the other reported inhibitors, the oxime nitrogen and halogen bond interaction are identified as the unique features of INCB14943 among the IDO1 inhibitors.	Oximes	50-55	indoleamine 2,3-dioxygenase 1	Homo sapiens	155-159
27125569-1	2017	Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream.	Oximes	209-214	butyrylcholinesterase	Homo sapiens	0-22
27125569-1	2017	Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream.	Oximes	209-214	butyrylcholinesterase	Homo sapiens	24-28
27125569-1	2017	Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream.	Oximes	209-214	butyrylcholinesterase	Homo sapiens	162-166
27125569-0	2017	Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.	Oximes	27-33	butyrylcholinesterase	Homo sapiens	56-78
28097769-6	2017	The location of this oxime with the PLP, which forms in place of the native internal aldimine linkage of PLP of the native KAT-I, is away from the position of the native internal aldimine, with the free Lys247 substantially retaining the orientation of the native structure.	Oximes	21-26	pyridoxal phosphatase	Homo sapiens	36-39
28097769-6	2017	The location of this oxime with the PLP, which forms in place of the native internal aldimine linkage of PLP of the native KAT-I, is away from the position of the native internal aldimine, with the free Lys247 substantially retaining the orientation of the native structure.	Oximes	21-26	pyridoxal phosphatase	Homo sapiens	105-108
28097769-6	2017	The location of this oxime with the PLP, which forms in place of the native internal aldimine linkage of PLP of the native KAT-I, is away from the position of the native internal aldimine, with the free Lys247 substantially retaining the orientation of the native structure.	Oximes	21-26	kynurenine aminotransferase 1	Homo sapiens	123-128
31294152-5	2017	Oximes are compounds that reactivate Acetylcholinesterase (AChE), a regulatory enzyme responsible for the transmission of nerve impulses, which is one of the molecular targets most vulnerable to neurotoxic agents.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
31294152-5	2017	Oximes are compounds that reactivate Acetylcholinesterase (AChE), a regulatory enzyme responsible for the transmission of nerve impulses, which is one of the molecular targets most vulnerable to neurotoxic agents.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
27358236-2	2017	One current approach is directed toward synthesizing oximes with high affinity and reactivatability toward butyrylcholinesterase (BChE) in plasma to generate an effective pseudocatalytic scavenger.	Oximes	53-59	butyrylcholinesterase	Homo sapiens	130-134
27358236-3	2017	An interim solution could be the administration of external AChE or BChE from blood products to augment pseudocatalytic scavenging with slower but clinically approved oximes to decrease nerve agent concentrations in the body.	Oximes	167-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
27358236-3	2017	An interim solution could be the administration of external AChE or BChE from blood products to augment pseudocatalytic scavenging with slower but clinically approved oximes to decrease nerve agent concentrations in the body.	Oximes	167-173	butyrylcholinesterase	Homo sapiens	68-72
28165084-0	2017	Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study.	Oximes	25-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
28119957-2	2017	The resulting Ni/ACOX catalyst is highly active and chemoselective for hydrogenation of nitroarenes to produce functionalized anilines and oximes.	Oximes	139-145	acyl-CoA oxidase 1	Homo sapiens	17-21
27908452-9	2017	This study concludes that NO3- formation during ozonation of DON is induced by an oxygen-transfer to nitrogen forming hydroxylamine and oxime, while NH4+ formation is induced by electron-transfer reactions involving C-centered radicals and imine intermediates.	Oximes	136-141	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
28124920-0	2017	Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.	Oximes	43-48	insulin	Homo sapiens	24-31
26612005-0	2016	Docking and molecular dynamics studies of peripheral site ligand-oximes as reactivators of sarin-inhibited human acetylcholinesterase.	Oximes	65-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-133
28596833-7	2017	The oxime M41 accounted for only 0.62% of the total plasma radioactivity and was detected only at early time points.	Oximes	4-9	DSCAM antisense RNA 1	Homo sapiens	10-13
27582056-9	2016	Among further modifications of known oximes, the main attention has been paid to dual binding site ligands of AChE as the current mainstream strategy.	Oximes	37-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-114
26612005-1	2016	In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders of acetylcholinesterase (AChE) and potential penetrators on the blood brain barrier.	Oximes	116-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-188
26612005-1	2016	In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders of acetylcholinesterase (AChE) and potential penetrators on the blood brain barrier.	Oximes	116-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-182
26899146-13	2016	In particular, association of cholinesterase mutants (not susceptible to age after phosphylation) with fast-reactivating oximes leads to pseudocatalytic bioscavengers.	Oximes	121-127	butyrylcholinesterase	Homo sapiens	30-44
27062893-0	2016	Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.	Oximes	30-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-72
27062893-2	2016	2PAM reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent.	Oximes	82-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
27125761-2	2016	The need for an effective treatment of OP poisoning resulted in the implementation of a combination therapy with the muscarinic receptor antagonist atropine and an oxime for the reactivation of OP-inhibited acetylcholinesterase (AChE).	Oximes	164-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	229-233
27125761-6	2016	Multiple in vitro and in vivo studies investigated the potential of oximes to reactivate OP-inhibited AChE and to reverse OP-induced cholinergic signs.	Oximes	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-106
27129421-1	2016	The antidotal treatment of organophosphates (OP) nerve agents (NA) poisoning is based on anticholinergics (e.g. atropine) combined with oxime reactivators (e.g. 2PAM) of acetylcholinesterase (AChE).	Oximes	136-141	acetylcholinesterase	Rattus norvegicus	170-190
27238725-1	2016	Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Oximes	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	165-185
27238725-1	2016	Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Oximes	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
27238725-1	2016	Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Oximes	56-61	butyrylcholinesterase	Homo sapiens	197-218
27238725-1	2016	Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Oximes	56-61	butyrylcholinesterase	Homo sapiens	220-224
27387540-5	2016	A number of these novel oximes have shown the ability to decrease the level of ChE inhibition in the brains of rats treated with a high sublethal dosage of either a sarin surrogate (nitrophenyl isopropyl methylphosphonate, NIMP) or the VX surrogate NEMP.	Oximes	24-30	butyrylcholinesterase	Rattus norvegicus	79-82
27387540-8	2016	Therefore these novel oximes have demonstrated an ability to reactivate inhibited ChE in brain preparations from two species and in vivo data support their ability to enter the brain and provide a therapeutic action.	Oximes	22-28	butyrylcholinesterase	Rattus norvegicus	82-85
27785869-5	2016	To address this issue, we report the synthesis of a covalent RANTES-PF4 heterodimer (termed OPRAH) by total chemical synthesis and oxime ligation, with an acceleration of the final ligation step driven by PPIs between RANTES and PF4.	Oximes	131-136	C-C motif chemokine ligand 5	Homo sapiens	61-67
27785869-5	2016	To address this issue, we report the synthesis of a covalent RANTES-PF4 heterodimer (termed OPRAH) by total chemical synthesis and oxime ligation, with an acceleration of the final ligation step driven by PPIs between RANTES and PF4.	Oximes	131-136	platelet factor 4	Homo sapiens	68-71
27693733-5	2016	As the results have shown, the tested oximes were in general more efficient in the reactivation of OP-inhibited BChE than AChE.	Oximes	38-44	butyrylcholinesterase	Homo sapiens	112-116
27693733-7	2016	The cholinesterases displayed a binding affinity for these derivatives in a mumolar range no matter the substituent on their rings which was in accordance with the molecular modelling results showing a similar binding pattern for all oximes within the active site of both AChE and BChE.	Oximes	234-240	acetylcholinesterase (Cartwright blood group)	Homo sapiens	272-276
27693733-7	2016	The cholinesterases displayed a binding affinity for these derivatives in a mumolar range no matter the substituent on their rings which was in accordance with the molecular modelling results showing a similar binding pattern for all oximes within the active site of both AChE and BChE.	Oximes	234-240	butyrylcholinesterase	Homo sapiens	281-285
27581755-0	2016	Discovery of Chromeno[4,3-c]pyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kalpha.	Oximes	69-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	122-131
27371941-2	2016	Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime antidotes.	Oximes	154-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-30
27654152-0	2016	A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers.	Oximes	36-42	butyrylcholinesterase	Homo sapiens	58-79
27654152-2	2016	An additional improvement in medical countermeasures would be to use oximes that could reactivate BChE as well to upgrade bioscavenging from stoichiometric to oxime-assisted catalytic.	Oximes	69-75	butyrylcholinesterase	Homo sapiens	98-102
27654152-2	2016	An additional improvement in medical countermeasures would be to use oximes that could reactivate BChE as well to upgrade bioscavenging from stoichiometric to oxime-assisted catalytic.	Oximes	69-74	butyrylcholinesterase	Homo sapiens	98-102
27654152-5	2016	A comprehensive analysis was performed for the most promising oximes defining kinetic parameters of reactivation as well as interactions with uninhibited BChE.	Oximes	62-68	butyrylcholinesterase	Homo sapiens	154-158
27654152-9	2016	The obtained protection in VX poisoning outlines its potential in development oxime-assisted OP-bioscavenging with BChE.	Oximes	78-83	butyrylcholinesterase	Homo sapiens	115-119
27624074-0	2016	Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.	Oximes	15-20	polo like kinase 1	Homo sapiens	100-118
27494215-0	2016	Biological Testing of Organophosphorus-Inactivated Acetylcholinesterase Oxime Reactivators Identified via Virtual Screening.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-71
27494215-4	2016	In order to find new starting points for the development of oxime-containing therapeutic reactivators and to increase our base of knowledge, we have employed a combination of computational and experimental procedures to identify additional compounds with the real or potential ability to reactivate AChE while augmenting and complementing current knowledge.	Oximes	60-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	299-303
27460171-4	2016	Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.	Oximes	81-86	histone deacetylase 1	Homo sapiens	117-122
28327676-9	2016	Oximes reactivate cholinesterase enzymes and help to overcome even the nicotinic effects of OP poisoning.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	18-32
27191504-4	2016	We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes.	Oximes	139-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
27191504-8	2016	Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation.	Oximes	88-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67
27212630-4	2016	Modification of C-6 of 11-nortetrodotoxin-6,6-diol to form an oxime derivative decreased the activity to 1/22.	Oximes	62-67	complement component 6	Mus musculus	16-19
27450532-6	2016	In comparison to 2-PAM and obidoxime, oxime 4a and 4b exhibited enhanced reactivation efficacy toward sarin inhibited hAChE while oxime 4c showed far greater reactivation efficacy toward VX inhibited hAChE.	Oximes	38-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-123
27371941-3	2016	Antidote efficacy is limited by the structural diversity of OP-AChE conjugates resulting from differences in the structure of the conjugated OP, the different active-center volumes they occupy when conjugated to the active-center serine of AChE, and the distinct chemical characteristics of both OPs and oximes documented in numerous X-ray structures of OP-conjugated AChEs.	Oximes	304-310	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
27371941-4	2016	Efforts to improve oxime reactivation efficacy by AChE structure-based enhancement of oxime structure have yielded only limited success.	Oximes	19-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54
27371941-4	2016	Efforts to improve oxime reactivation efficacy by AChE structure-based enhancement of oxime structure have yielded only limited success.	Oximes	86-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54
27371941-5	2016	We outline here the potential limitations of available AChE X-ray structures that preclude an accurate prediction of oxime structures, which are necessary for association in the OP-AChE gorge and nucleophilic attack of the OP-conjugated phosphorus.	Oximes	117-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59
27371941-5	2016	We outline here the potential limitations of available AChE X-ray structures that preclude an accurate prediction of oxime structures, which are necessary for association in the OP-AChE gorge and nucleophilic attack of the OP-conjugated phosphorus.	Oximes	117-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
27177985-0	2016	Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor.	Oximes	41-47	acetylcholinesterase	Rattus norvegicus	79-99
27396356-1	2016	BACKGROUND: Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase.	Oximes	86-92	peptidylglycine alpha-amidating monooxygenase	Canis lupus familiaris	117-120
27396356-1	2016	BACKGROUND: Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase.	Oximes	86-92	acetylcholinesterase	Canis lupus familiaris	150-170
27177985-1	2016	As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing.	Oximes	3-8	acetylcholinesterase	Rattus norvegicus	90-110
27177985-1	2016	As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing.	Oximes	3-8	acetylcholinesterase	Rattus norvegicus	112-116
27131125-5	2016	While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray.	Oximes	118-123	neuraminidase 1	Homo sapiens	162-175
26930003-3	2016	SZV-1287 is a new 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime SSAO inhibitor, its chemical structure is similar to other oxime derivatives described as TRPA1 antagonists.	Oximes	59-64	amine oxidase, copper containing 3	Rattus norvegicus	65-69
27371941-0	2016	Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning.	Oximes	70-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-43
26930003-10	2016	This is the first evidence that our novel oxime compound SZV-1287 originally developed as a SSAO inhibitor has a potent dual antagonistic action on TRPA1 and TRPV1 ion channels on primary sensory neurons.	Oximes	42-47	amine oxidase, copper containing 3	Rattus norvegicus	92-96
26930003-10	2016	This is the first evidence that our novel oxime compound SZV-1287 originally developed as a SSAO inhibitor has a potent dual antagonistic action on TRPA1 and TRPV1 ion channels on primary sensory neurons.	Oximes	42-47	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	148-153
26930003-10	2016	This is the first evidence that our novel oxime compound SZV-1287 originally developed as a SSAO inhibitor has a potent dual antagonistic action on TRPA1 and TRPV1 ion channels on primary sensory neurons.	Oximes	42-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	158-163
27327269-6	2016	For postaging treatment, realkylation of aged AChE by appropriate alkylators may pave the way for oxime treatment by neutralizing the oxyanion at the active site of aged AChE.	Oximes	98-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
27327269-6	2016	For postaging treatment, realkylation of aged AChE by appropriate alkylators may pave the way for oxime treatment by neutralizing the oxyanion at the active site of aged AChE.	Oximes	98-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	170-174
27153507-0	2016	Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.	Oximes	24-30	butyrylcholinesterase	Rattus norvegicus	51-65
26879641-2	2016	We have examined the structural features of the tabun-conjugated AChE complex with an oxime reactivator, Ortho-7, to provide a strategy for designing new and efficient reactivators.	Oximes	86-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
27153507-1	2016	Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo.	Oximes	8-13	butyrylcholinesterase	Rattus norvegicus	57-71
27153507-1	2016	Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo.	Oximes	8-13	butyrylcholinesterase	Rattus norvegicus	73-76
27153507-4	2016	In addition, treatment of rats with these novel oximes is associated with attenuation of seizure-like behavior compared to rats treated with 2-PAM, providing additional evidence that the oximes penetrate the blood-brain barrier.	Oximes	187-193	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	143-146
27101948-0	2016	Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-127
27101948-9	2016	Studies stipulated that butene-linked oximes consisting of different functional moieties are good reactivators and found to have better efficacy to reactivate nerve agent-inhibited human AChE in comparison to eel AChE.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
27101948-9	2016	Studies stipulated that butene-linked oximes consisting of different functional moieties are good reactivators and found to have better efficacy to reactivate nerve agent-inhibited human AChE in comparison to eel AChE.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	213-217
27042207-6	2016	Several oximes are found to be hyperglycemic, anti-neoplastic, anti-inflammatory, anti-leishmanial and VEGFR-2 kinase inhibitors.	Oximes	8-14	kinase insert domain receptor	Homo sapiens	103-110
27010345-6	2016	Oxime analog 7o displayed the most potent EGFR TK inhibitory activity with an IC50 of 0.07 muM, which was analogous to the positive control.	Oximes	0-5	epidermal growth factor receptor	Homo sapiens	42-46
27000635-2	2016	The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct.	Oximes	141-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-125
27000635-2	2016	The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct.	Oximes	141-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
27000635-2	2016	The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct.	Oximes	141-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	193-197
26809136-4	2016	The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6.	Oximes	25-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
26851641-1	2016	Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE).	Oximes	144-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-198
26851641-1	2016	Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE).	Oximes	144-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	200-204
27153754-0	2016	Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
27153754-3	2016	To investigate the ability of obidoxime, HI-6 and the combination of both oximes to reactivate inhibited human AChE in the presence of sarin, cyclosarin or tabun we adopted a dynamic in vitro model with real-time and continuous determination of AChE activity to simulate inhalation nerve agent exposure and intramuscular oxime administration.	Oximes	74-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
27153754-5	2016	The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54
25743373-2	2016	Inhibited AChE can be reactivated by cleavage of the Ser-phosphorus bond either spontaneously or through a reaction with nucleophilic agents, such as oximes.	Oximes	150-156	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-14
25743373-5	2016	Here, our goal was to study oxime reactivation and aging reactions of human AChE inhibited by mipafox or a sarin analog (Flu-MPs, fluorescent methylphosphonate).	Oximes	28-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
26519930-0	2015	Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model.	Oximes	6-11	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
28959540-4	2016	Currently approved antidotes against OPs include the peripheral anticholinergic drug atropine and an oxime that reactivates the inhibited cholinesterase.	Oximes	101-106	butyrylcholinesterase	Homo sapiens	138-152
26368669-1	2015	Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine.	Oximes	88-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
26368669-1	2015	Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine.	Oximes	88-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
26368669-1	2015	Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine.	Oximes	88-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
26368669-1	2015	Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine.	Oximes	88-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
26368669-2	2015	In addition, AChE inhibited by close tabun analogues, N,N-diethyltabun and N,N-di-n-propyltabun was completely resistant towards reactivation by oximes.	Oximes	145-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-17
26368669-3	2015	In order to get more insight into potential mechanisms of this oxime resistance experiments with these toxic agents and the oximes obidoxime, 2-PAM, MMB-4 and HI-6 were performed utilizing a dynamic model with real-time determination of AChE activity.	Oximes	63-68	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	144-147
26368669-3	2015	In order to get more insight into potential mechanisms of this oxime resistance experiments with these toxic agents and the oximes obidoxime, 2-PAM, MMB-4 and HI-6 were performed utilizing a dynamic model with real-time determination of AChE activity.	Oximes	63-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	237-241
26368669-8	2015	These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE.	Oximes	161-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
26368669-8	2015	These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE.	Oximes	161-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	298-302
26368669-8	2015	These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE.	Oximes	161-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
26368669-8	2015	These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE.	Oximes	161-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	298-302
26210933-1	2016	The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP).	Oximes	45-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
26210933-1	2016	The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP).	Oximes	116-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-167
26210933-1	2016	The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP).	Oximes	116-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
26210933-4	2016	Several oximes with superior reactivating potency towards selective OP-AChE conjugates were identified but none of the tested oximes can be considered as a broad spectrum reactivator.	Oximes	8-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
26747974-2	2016	Both oximes are very potent reactivators of organophosphate-inhibited AChE.	Oximes	5-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
26705700-5	2016	Brain cholinesterase inhibition was slightly less in novel oxime treated rats compared to 2-PAM in the 24h survivors.	Oximes	59-64	butyrylcholinesterase	Rattus norvegicus	6-20
26519930-1	2015	We have designed and synthesized certain novel oxime- and amide-bearing coumarin derivatives as nuclear factor erythroid 2 p45-related factor 2 (Nrf2) activators.	Oximes	47-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
26519930-7	2015	These results suggested that novel oxime-bearing coumarin 17a is able to activate Nrf2/ARE pathway in vivo and are therefore seen as a promising candidate for further investigation.	Oximes	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
26468911-0	2015	Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge.	Oximes	76-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
25945727-5	2015	An aminooxy-modified LXR agonist was conjugated to anti-CD11a IgG through a stable, cathepsin B cleavable oxime linkage to afford a chemically defined ADC.	Oximes	106-111	integrin subunit alpha L	Homo sapiens	56-61
25945727-5	2015	An aminooxy-modified LXR agonist was conjugated to anti-CD11a IgG through a stable, cathepsin B cleavable oxime linkage to afford a chemically defined ADC.	Oximes	106-111	cathepsin B	Homo sapiens	84-95
26468911-2	2015	We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water.	Oximes	11-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
25407587-0	2015	Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents.	Oximes	63-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-98
26594472-3	2015	Further, the O atom of the benzo-furan ring is syn to the N atom of the oxime group.	Oximes	72-77	synemin	Homo sapiens	47-50
25963916-0	2015	Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues.	Oximes	29-34	progestagen associated endometrial protein	Homo sapiens	47-50
26070418-7	2015	However, the synthesized oximes showed marginal reactivation efficacies in case of tabun inhibited hAChE.	Oximes	25-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-104
25907366-0	2015	Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators.	Oximes	13-18	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
25907366-5	2015	In the present study, certain oxime-bearing naphthalene derivatives were synthesized and evaluated for their Nrf2 activation and anti-proliferative activities.	Oximes	30-35	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
25963916-2	2015	A fast gelling oxime-crosslinked PEG hydrogel with tunable gelation time, degradation, and mechanical properties is presented.	Oximes	15-20	progestagen associated endometrial protein	Homo sapiens	33-36
25784649-2	2015	We recently synthesized the sodium salt of IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime) and demonstrated that it is a high-affinity JNK inhibitor and inhibits murine delayed-type hypersensitivity.	Oximes	85-90	mitogen-activated protein kinase 8	Mus musculus	136-139
25835984-2	2015	Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against soman, while the efficacy of the recommended nerve agent bioscavenger butyrylcholinesterase is limited by strictly stoichiometric scavenging.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
25753941-0	2015	Rh(III)-catalyzed oxime ether-directed heteroarylation of arene through oxidative C-H/C-H cross-coupling.	Oximes	18-23	churchill domain containing 1	Homo sapiens	82-89
25701203-2	2015	Here we evaluated the zebrafish as a potential pharmacological model for screening novel oxime antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE).	Oximes	89-94	acetylcholinesterase	Danio rerio	161-165
25701203-5	2015	However, differences between the Kox and k2 constants suggest that zebrafish AChE associates more tightly with oximes, but has a slower maximal reactivation rate than human AChE.	Oximes	111-117	acetylcholinesterase	Danio rerio	77-81
24912784-5	2015	Human plasma was incubated with OP and the reactivation of inhibited BChE was tested with multiple oxime concentrations followed by nonlinear regression analysis for the determination of reactivity, affinity and overall reactivation constants.	Oximes	99-104	butyrylcholinesterase	Homo sapiens	69-73
24912784-6	2015	The generated data indicate that the tested oximes have a low-to-negligible reactivating potency with paraoxon- and tabun-inhibited human BChE.	Oximes	44-50	butyrylcholinesterase	Homo sapiens	138-142
25451328-1	2015	In this study, we employed site-directed mutagenesis to understand the role of amino acids in the gorge in oxime-induced reactivation of nerve agent-inhibited human (Hu) acetylcholinesterase (AChE).	Oximes	107-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196
24912784-7	2015	Several oximes showed a moderate-to-high potency with cyclosarin-inhibited BChE.	Oximes	8-14	butyrylcholinesterase	Homo sapiens	75-79
24912784-9	2015	In the end, novel structures of oxime and non-oxime reactivators are urgently needed for the development of human BChE into an effective pseudo-catalytic scavenger.	Oximes	32-37	butyrylcholinesterase	Homo sapiens	114-118
24912784-9	2015	In the end, novel structures of oxime and non-oxime reactivators are urgently needed for the development of human BChE into an effective pseudo-catalytic scavenger.	Oximes	46-51	butyrylcholinesterase	Homo sapiens	114-118
25522658-0	2015	Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.	Oximes	32-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-120
25894563-1	2015	The ability of two novel bispyridinium oximes K727 and K733 and currently available oximes (HI-6, obidoxime) to reactivate sarin-inhibited acetylcholinesterase and to reduce acute toxicity of sarin was evaluated.	Oximes	39-45	acetylcholinesterase	Rattus norvegicus	139-159
25522658-4	2015	Hereby, oxime-induced reactivation of OP-inhibited non-human AChE was reported to be accelerated by different AChE-ligands.	Oximes	8-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
25522658-4	2015	Hereby, oxime-induced reactivation of OP-inhibited non-human AChE was reported to be accelerated by different AChE-ligands.	Oximes	8-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-114
25522658-5	2015	To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed.	Oximes	133-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-37
25522658-5	2015	To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed.	Oximes	133-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180
25522658-5	2015	To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed.	Oximes	133-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180
25522658-6	2015	Several ligands competed with the oxime for the AChE binding-site impairing reactivation of OP-inhibited AChE whereas a markedly accelerated reactivation of sarin-inhibited enzyme by obidoxime was recorded in the presence of edrophonium, galanthamine and donepezil.	Oximes	34-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
25522658-6	2015	Several ligands competed with the oxime for the AChE binding-site impairing reactivation of OP-inhibited AChE whereas a markedly accelerated reactivation of sarin-inhibited enzyme by obidoxime was recorded in the presence of edrophonium, galanthamine and donepezil.	Oximes	34-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
25450746-0	2015	Adaptation of a dynamic in vitro model with real-time determination  of butyrylcholinesterase activity in the presence of cyclosarin and an  oxime.	Oximes	141-146	butyrylcholinesterase	Homo sapiens	72-93
25369775-0	2015	Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1.	Oximes	28-33	solute carrier family 6 member 1	Homo sapiens	85-89
25461321-1	2015	Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through virtual screening of an in-house compound database.	Oximes	93-99	acetylcholinesterase	Rattus norvegicus	234-238
25461321-1	2015	Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through virtual screening of an in-house compound database.	Oximes	93-98	acetylcholinesterase	Rattus norvegicus	234-238
25461323-2	2015	A series of novel VEGFR-2 inhibitors containing oxime as hinge binding fragment were described.	Oximes	48-53	kinase insert domain receptor	Homo sapiens	18-25
25461323-4	2015	The oxime group was firstly introduced to interact with hinge region of VEGFR-2.	Oximes	4-9	kinase insert domain receptor	Homo sapiens	72-79
25373357-0	2015	Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.	Oximes	137-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
25497132-0	2015	Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175.	Oximes	71-77	peroxisome proliferator activated receptor alpha	Homo sapiens	96-144
25373357-1	2015	INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE.	Oximes	41-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113
25373357-1	2015	INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE.	Oximes	41-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
25373357-1	2015	INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE.	Oximes	41-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	314-318
25373357-5	2015	EXPERT OPINION: The structural differences of the organophosphorus compounds (OP) and the available oximes reactivators of OP-inhibited AChE generate distinct toxicokinetic or PK profiles.	Oximes	100-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-140
25351635-0	2015	Oxime bond-linked daunorubicin-GnRH-III bioconjugates exert antitumor activity in castration-resistant prostate cancer cells via the type I GnRH receptor.	Oximes	0-5	gonadotropin releasing hormone receptor	Homo sapiens	133-153
25894563-6	2015	On the other hand, the oxime HI-6 was found to be the most efficient reactivator of sarin-inhibited acetylcholinesterase.	Oximes	23-28	acetylcholinesterase	Rattus norvegicus	100-120
24805972-0	2015	Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Oximes	169-174	complement C3	Homo sapiens	67-70
25845909-1	2015	Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE).	Oximes	42-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Oximes	169-174	RNA polymerase III subunit K	Homo sapiens	75-79
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Oximes	169-174	complement C3	Homo sapiens	135-138
25304213-8	2015	However, in the presence of eight novel oximes, PON1-mediated degradation of both surrogates occurs.	Oximes	40-46	paraoxonase 1	Homo sapiens	48-52
25479380-1	2014	For three random splits, one-variable models of oximes reactivation of sarin inhibited acetylcholinesterase (logarithm of the AChE reactivation percentage by oximes with concentration of 0.001 M) have been calculated with CORAL software.	Oximes	48-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
25240274-6	2014	This effect was not observed when incubating highly diluted AChE with oximes.	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
25190468-1	2014	The search of proficient oximes as reactivators of irreversibly inhibited-AChE by organophosphate poisoning necessitates an appropriate assessment of their physicochemical properties and reactivation kinetics.	Oximes	25-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
25218671-0	2014	Quantum chemical and steered molecular dynamics studies for one pot solution to reactivate aged acetylcholinesterase with alkylator oxime.	Oximes	132-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
25218671-1	2014	Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct.	Oximes	38-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
25218671-1	2014	Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct.	Oximes	38-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
25218671-5	2014	The free enzyme can be liberated from the inhibited acetylcholinesterase with the sulfonium compound decorated with an oxime group to avoid the administration of oxime drugs separately.	Oximes	119-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-72
25218671-5	2014	The free enzyme can be liberated from the inhibited acetylcholinesterase with the sulfonium compound decorated with an oxime group to avoid the administration of oxime drugs separately.	Oximes	162-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-72
25218671-12	2014	The computational study suggests that the newly designed oxime is a potential candidate to reactivate the aged-AChE adduct.	Oximes	57-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
25346249-8	2014	Shift of DFP induced brain AChE IC50 curves to right was observed at 0.20 LD50 treatment dose of oximes with respect to 2-PAM.	Oximes	97-103	acetylcholinesterase	Mus musculus	27-31
25190468-4	2014	Further the tested oximes were screened through in vitro reactivation kinetics against paraoxon-inhibited AChE.	Oximes	19-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
25045021-0	2014	The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.	Oximes	103-109	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	Oximes	125-131	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-6	2014	However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1.	Oximes	41-47	mitochondrial amidoxime reducing component 2	Mus musculus	94-99
25045021-6	2014	However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1.	Oximes	41-47	mitochondrial amidoxime reducing component 2	Mus musculus	104-109
25045021-6	2014	However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1.	Oximes	41-47	mitochondrial amidoxime reducing component 2	Mus musculus	164-169
24136594-9	2014	Prophylactic administration of an oxime (such as K-27) in case of imminent OPC exposure may be a viable option.	Oximes	34-39	keratin 27	Rattus norvegicus	49-53
25016257-5	2014	(1) The 1H-NMR signals at ~5.5, 4-8, 7.4-10.2, and 12.22-12.37 ppm were attributed to the chemical shifts of active protons on carbons adjacent to R-OH, RAr-OH, oximes, and -COOH, respectively.	Oximes	161-167	RAB40B, member RAS oncogene family	Homo sapiens	153-156
24964273-3	2014	Tabun is one of the highly toxic organophosphorus (OP) compounds and is resistant to many oxime drugs formulated for the reactivation of AChE.	Oximes	90-95	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-141
24902036-0	2014	Ketoxime coupling of p-acetylphenylalanine at neutral pH for site-directed spin labeling of human sulfite oxidase.	Oximes	0-8	sulfite oxidase	Homo sapiens	98-113
24902036-1	2014	Site-directed spin labeling of the unnatural amino acid p-acetylphenylalanine (p-AcPhe) using oxime based coupling chemistry is successfully applied to investigate human sulfite oxidase (hSO), a protein containing an essential cysteine residue, which impedes the use of thiol based coupling chemistry.	Oximes	94-99	sulfite oxidase	Homo sapiens	170-185
24549829-0	2014	Unbinding free energy of acetylcholinesterase bound oxime drugs along the gorge pathway from metadynamics-umbrella sampling investigation.	Oximes	52-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-45
25006785-10	2014	We observed the involvement of BKCa channels in Oxime S1-induced relaxation in mesenteric artery rings.	Oximes	48-53	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	31-35
23962483-0	2013	Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates.	Oximes	55-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
24129980-5	2014	This is confirmed using HEK-293 cells transfected to express human HDC and the aminooxy analog of histidine, 4(5)-aminooxymethylimidazole (O-IMHA, IC50   2 x 10(-7) M) capable to form a PLP-inhibitor complex (oxime) in the enzyme active center.	Oximes	209-214	histidine decarboxylase	Homo sapiens	67-70
24129980-6	2014	Taking advantage of the availability of the human HDC X-ray structure, we have also determined the potential interactions that could stabilize this oxime in the active site of mammalian HDC.	Oximes	148-153	histidine decarboxylase	Homo sapiens	50-53
24129980-6	2014	Taking advantage of the availability of the human HDC X-ray structure, we have also determined the potential interactions that could stabilize this oxime in the active site of mammalian HDC.	Oximes	148-153	histidine decarboxylase	Homo sapiens	186-189
24345352-1	2014	Reactivation of organophosphate (OP) inhibited acetylcholinesterase (AChE) by oximes is inadequate against various OP nerve agents known till date owing to their diverse structural features.	Oximes	78-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
24345352-3	2014	The efficacy of oxime reactivators is estimated through different in vitro and in vivo models using AChE from various sources against structurally different OPs.	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104
24345352-7	2014	The enhanced reactivation efficacy of oximes may be attributed to the optimal length of xylene linker which facilitates appropriate positioning of carbamoyl function to the peripheral anionic site (PAS) and extending the oxime moiety to the active site of AChE.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260
24345352-7	2014	The enhanced reactivation efficacy of oximes may be attributed to the optimal length of xylene linker which facilitates appropriate positioning of carbamoyl function to the peripheral anionic site (PAS) and extending the oxime moiety to the active site of AChE.	Oximes	38-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260
24057572-1	2014	Great efforts have been undertaken in the last decades to develop new oximes to reactivate acetylcholinesterase inhibited by organophosphorus compounds (OP).	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
24283935-1	2014	A novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA).	Oximes	8-13	intercellular adhesion molecule 1	Homo sapiens	59-65
24599312-3	2014	Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.	Oximes	16-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
24658567-1	2014	A new series of oxime ethers 4a-z was designed and synthesized to test the blocking activity against beta1 and beta2-adrenergic receptors.	Oximes	16-21	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	101-106
24658567-1	2014	A new series of oxime ethers 4a-z was designed and synthesized to test the blocking activity against beta1 and beta2-adrenergic receptors.	Oximes	16-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	111-116
24258240-0	2014	Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	11-31
24295433-1	2014	The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods.	Oximes	35-41	butyrylcholinesterase	Rattus norvegicus	88-102
24295433-1	2014	The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods.	Oximes	35-40	butyrylcholinesterase	Rattus norvegicus	88-102
24295433-3	2014	In the brain, the potency of both newly developed oximes to reactivate tabun-inhibited cholinesterase was negligible.	Oximes	50-56	butyrylcholinesterase	Rattus norvegicus	87-101
24443939-0	2014	Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.	Oximes	44-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-145
24443939-2	2014	The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates.	Oximes	98-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
24443939-8	2014	The reactivation of AChE inactivated with either cyclosarin or tabun requires the oxime therapeutic to possess an overall polar-positive surface area.	Oximes	82-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
24443939-9	2014	Oxime therapeutics for the reactivation of sarin-inactivated AChE are conformationally dependent while oxime reverse therapeutics for VX require a compact region with a highly hydrophilic region and two positively charged pyridine rings.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
24344993-5	2014	In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran.	Oximes	58-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
24200808-1	2013	An analysis of the main pharmacophoric features present in the still limited number of inhibitors of glucose transporter GLUT1 led to the identification of new oxime-based inhibitors, which proved to be able to efficiently hinder glucose uptake and cell growth in H1299 lung cancer cells.	Oximes	160-165	solute carrier family 2 member 1	Homo sapiens	121-126
23962483-4	2013	Therefore, we performed an in vitro kinetic study to investigate the effect of clinically used oximes on carbamoylation and decarbamoylation of human AChE.	Oximes	95-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
24312449-7	2013	The calculated activation barriers support the superiority of neutral oximes for the activation of tabun-inhibited AChE compared to charged oximes.	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
24312449-9	2013	Docking studies revealed that the poor binding affinity of simple neutral oxime drugs such as 3-hydroxy-2-pyridinealdoxime inside the active-site gorge of AChE was significantly augmented with the addition of neutral peripheral units compared to conventional charged peripheral sites.	Oximes	74-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
24161674-5	2013	Substitution of 5 amino acid residues in combination with the use of an oxime linker for dimerization increased the solubility and chemical stability of the dimeric CXCL14(51-77).	Oximes	72-77	C-X-C motif chemokine ligand 14	Homo sapiens	165-171
24157926-2	2013	Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated.	Oximes	53-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-149
24054643-6	2013	An oxime peak identifier (OPI) of the carbohydrate analytes, based on the combination of an internal standard and the corresponding syn/anti peak ratios, increased the reliability of the identification of reducing carbohydrates.	Oximes	3-8	synemin	Homo sapiens	132-135
23735753-9	2013	On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin.	Oximes	24-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
23735753-9	2013	On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin.	Oximes	24-29	kininogen 1	Homo sapiens	187-197
23735753-9	2013	On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin.	Oximes	24-29	kininogen 1	Homo sapiens	217-227
23789829-0	2013	In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
23789829-0	2013	In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators.	Oximes	53-58	activation induced cytidine deaminase	Homo sapiens	109-112
23789829-3	2013	The model was generated from published experimental percentage reactivation data on oximes as changes of AChE/BuChE activities in the whole blood after cyclosarin intoxication and administration.	Oximes	84-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
23789829-6	2013	Furthermore, from virtual screening of two commercial databases, Maybridge and ChemNavigator using map-fitting of the model led us to identify two new non-oxime compounds showing reactivation efficacy within 10-fold range of 2-PAM for DFP-inhibited AChE.	Oximes	155-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	249-253
23680647-0	2013	Kinetic analysis of inhibition of glucoamylase and active site mutants via chemoselective oxime immobilization of acarbose on SPR chip surfaces.	Oximes	90-95	sepiapterin reductase	Homo sapiens	126-129
23631694-11	2013	Oxidation of the sialic acid side chains of Tf generated aldehyde functionalized protein that was reacted with aminooxy terminated poly(HPMA), which resulted in protein-polymer bioconjugates carrying oxime linkages.	Oximes	200-205	transferrin	Homo sapiens	44-46
23959117-0	2013	Oximes: inhibitors of human recombinant acetylcholinesterase.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-60
23959117-3	2013	Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity.	Oximes	107-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
23959117-4	2013	However, oximes also bind to the active site of AChE, simultaneously acting as reversible inhibitors.	Oximes	9-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
23959117-5	2013	The goal of the present study is to determine how oxime structure influences the inhibition of human recombinant AChE (hrAChE).	Oximes	50-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
22960624-0	2013	Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.	Oximes	17-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
22827894-0	2013	Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
22827894-1	2013	Treatment of poisoning by various organophosphorus (OP) nerve agents with established acetylcholinesterase (AChE) reactivators (oximes) is insufficient.	Oximes	128-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-106
22827894-1	2013	Treatment of poisoning by various organophosphorus (OP) nerve agents with established acetylcholinesterase (AChE) reactivators (oximes) is insufficient.	Oximes	128-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
22827894-4	2013	The crucial mechanism of action of oximes is the reactivation of phosphylated AChE.	Oximes	35-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
22827894-6	2013	It was tempting to evaluate the reactivation kinetics of a series of oximes with various OP inhibitors performed under identical experimental conditions in order to get insight into structural requirements for adequate affinity and reactivity towards inhibited AChE.	Oximes	69-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	261-265
22827894-7	2013	The determination of reactivation rate constants with bispyridinium oximes having different linkers, bearing oxime group(s) at different positions and having in part additional substituents revealed that (a) the reactivating potency was dependent on the position of the oxime groups and of additional substituents, (b) small modifications of the oxime structure had an in part marked effect on the kinetic properties and (c) no single oxime had an adequate reactivating potency with AChE inhibited by structurally different OP.	Oximes	68-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	483-487
22982773-0	2013	A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.	Oximes	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-79
22982773-1	2013	Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE).	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-206
22982773-1	2013	Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE).	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	208-212
22982773-2	2013	Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary &gt;100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate.	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
22982773-2	2013	Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary &gt;100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate.	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143
22982773-3	2013	To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues.	Oximes	39-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
22982773-3	2013	To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues.	Oximes	142-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
22982773-4	2013	Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation.	Oximes	153-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
22982773-5	2013	Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
22982773-5	2013	Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	196-200
22982773-5	2013	Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	196-200
23047024-1	2013	Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms.	Oximes	37-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
23073172-1	2013	We are evaluating a facilitative transport strategy to move oximes across the blood brain barrier (BBB) to reactivate inhibited brain acetylcholinesterase (AChE).	Oximes	60-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	156-160
23422169-7	2013	Previous work has shown the success of oxime-based sensors in the selective detection of AChE inhibitors and this work highlights the ability of an AChE-inspired biomimetic sensor to accurately predict the toxicity (LD50 and LC50) for a range of AChE inhibitors.	Oximes	39-44	acetylcholinesterase	Rattus norvegicus	89-93
23422169-7	2013	Previous work has shown the success of oxime-based sensors in the selective detection of AChE inhibitors and this work highlights the ability of an AChE-inspired biomimetic sensor to accurately predict the toxicity (LD50 and LC50) for a range of AChE inhibitors.	Oximes	39-44	acetylcholinesterase	Rattus norvegicus	148-152
23422169-7	2013	Previous work has shown the success of oxime-based sensors in the selective detection of AChE inhibitors and this work highlights the ability of an AChE-inspired biomimetic sensor to accurately predict the toxicity (LD50 and LC50) for a range of AChE inhibitors.	Oximes	39-44	acetylcholinesterase	Rattus norvegicus	148-152
23314320-2	2013	The current U.S. military and civilian oxime countermeasure, 2-[(hydroxyimino)methyl]-1-methylpyridin-1-ium chloride (2-PAM), is under consideration for replacement with a more effective acetylcholinesterase reactivator, 1,1"-methylenebis{4-hydroxyiminomethyl}pyridinium dimethanesulfonate (MMB-4).	Oximes	39-44	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	120-123
23534424-1	2013	BACKGROUND: Extreme efforts are made for the structural diversification of oximes used as AChE reactivators.	Oximes	75-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
23073172-5	2013	Here we report the reactivation parameters for VX- and GB-inhibited human (Hu) AChE of the best SOx (13c) and our findings that the kinetics are similar to those of the parent oxime.	Oximes	176-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
23111374-4	2013	In this study, a series of seven new uncharged oximes reactivators have been synthesized and their in vitro ability to reactivate VX and tabun-inhibited human acetylcholinesterase (hAChE) has been evaluated.	Oximes	47-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
23111374-4	2013	In this study, a series of seven new uncharged oximes reactivators have been synthesized and their in vitro ability to reactivate VX and tabun-inhibited human acetylcholinesterase (hAChE) has been evaluated.	Oximes	47-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-186
23123249-0	2013	Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates.	Oximes	35-40	acetylcholinesterase	Rattus norvegicus	57-77
23123249-1	2013	A critical need for combating the effects of organophosphate (OP) anticholinesterases, such as nerve agents, is the current lack of an effective oxime reactivator which can penetrate the blood-brain barrier (BBB), and therefore reactivate inhibited acetylcholinesterase (AChE) in the brain.	Oximes	145-150	acetylcholinesterase	Rattus norvegicus	249-269
23123249-1	2013	A critical need for combating the effects of organophosphate (OP) anticholinesterases, such as nerve agents, is the current lack of an effective oxime reactivator which can penetrate the blood-brain barrier (BBB), and therefore reactivate inhibited acetylcholinesterase (AChE) in the brain.	Oximes	145-150	acetylcholinesterase	Rattus norvegicus	271-275
23123249-4	2013	The oximes demonstrated a range of 14-76% reactivation of rat brain AChE in vitro.	Oximes	4-10	acetylcholinesterase	Rattus norvegicus	68-72
23123249-5	2013	An in vivo testing paradigm was developed in which the novel oxime was administered at the time of maximal brain AChE inhibition (about 80%) (1h) elicited by nitrophenyl isopropyl methylphosphonate (NIMP; sarin surrogate).	Oximes	61-66	acetylcholinesterase	Rattus norvegicus	113-117
23123249-6	2013	This paradigm, with delayed administration of oxime to a time when brain AChE was starting to recover, was designed to minimize reactivation/reinhibition of peripheral AChE during the reactivation period which would decrease the availability of the surrogate for entry into the brain; this paradigm will allow proof of concept of BBB penetrability.	Oximes	46-51	acetylcholinesterase	Rattus norvegicus	168-172
23220589-6	2013	The aim of the present study was to evaluate the efficacy of some ChE reactivators against OPC intoxication (tabun, paraoxon and dichlorvos) in in vitro experiments and to compare their activity to that known for some currently used oximes (obidoxime, HI-6, 2-PAM).	Oximes	233-239	butyrylcholinesterase	Rattus norvegicus	66-69
22960624-4	2013	The oxime RS150D [N-((1-(3-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)benzamide] was highlighted as the most promising reactivator of the tabun-hAChE conjugate.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-186
22975155-1	2013	A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun.	Oximes	43-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-146
23339663-8	2013	X-ray crystallography and mass spectrometry show the formation of an aged end product formed in both AChE and BChE that cannot be reactivated by current oxime-based therapeutics.	Oximes	153-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
23339663-8	2013	X-ray crystallography and mass spectrometry show the formation of an aged end product formed in both AChE and BChE that cannot be reactivated by current oxime-based therapeutics.	Oximes	153-158	butyrylcholinesterase	Homo sapiens	110-114
22901042-2	2013	The study determining percentage of reactivation of tabun-inhibited diaphragm and brain acetylcholinesterase in poisoned rats showed that the reactivating efficacy of all newly developed oximes is comparable with K203 but lower than the reactivating potency of trimedoxime in diaphragm.	Oximes	187-193	acetylcholinesterase	Rattus norvegicus	88-108
23085985-6	2013	The Ag2 ion is coordinated to the N61 oxime nitrogens, a monodentate and a (O,O)-bridging nitrato/perchlorato or two monodentate O-trifluoromethylsulfonato anions.	Oximes	38-43	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	4-7
23184734-2	2013	We found that the HDAC potency and isoform selectivity provided by the oxime unit of psammaplin A could be reproduced by using carefully chosen heterocyclic frameworks.	Oximes	71-76	histone deacetylase 9	Homo sapiens	18-22
23410111-2	2013	Although oxime nucleophiles can reactivate the AChE-phosphyl adduct, the adduct undergoes a reaction called aging.	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
22561105-0	2012	Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase.	Oximes	65-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-142
23002990-2	2012	Treatment of O-arylmethyl alkynyl oxime ethers with 5 mol % of Cu(OTf)(2) in chlorobenzene at reflux gave 4-arylmethylisoxazoles in good to excellent yields via the sequential intramolecular addition of the oxime moiety to the alkyne with subsequent 1,3-migration of the arylmethyl group.	Oximes	34-39	POU class 2 homeobox 2	Homo sapiens	63-72
23461011-0	2013	[Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase].	Oximes	22-27	butyrylcholinesterase	Homo sapiens	72-86
23461011-1	2013	The kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase has been experimentally studied in vitro.	Oximes	16-21	butyrylcholinesterase	Homo sapiens	66-80
23176543-1	2013	INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles.	Oximes	78-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-124
23176543-1	2013	INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles.	Oximes	78-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
23176543-5	2013	The non-homogenous distribution of oximes versus OP in tissues was considered and correlated with the highly variable AChE reactivation at both peripheral and central levels.	Oximes	35-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122
22703537-11	2012	In conclusion, our work demonstrated that the newly synthesised oximes were able to reactivate not only human erythrocyte AChE but also human plasma BChE, which could represent an advantage in the treatment of OP compounds poisoning.	Oximes	64-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-126
22703537-11	2012	In conclusion, our work demonstrated that the newly synthesised oximes were able to reactivate not only human erythrocyte AChE but also human plasma BChE, which could represent an advantage in the treatment of OP compounds poisoning.	Oximes	64-70	butyrylcholinesterase	Homo sapiens	149-153
23047286-4	2012	The incorporation of oxime ethers on the carbonyl portion of the benzoyl group can bring the PPARalpha/gamma potency ratio equal to or slightly greater than one, as is the case for compounds 20 c and 21 a.	Oximes	21-26	peroxisome proliferator activated receptor alpha	Mus musculus	93-102
23136681-13	2004	synthesized two conjugates, [(18)F]-5 and [(18)F]-8, by conjugating [(18)F]FDG with folate and methotrexate (MTX), respectively, using the readily available oxime-reactive [(18)F]FDG building block (1).	Oximes	157-162	metaxin 1	Homo sapiens	109-112
22437842-1	2012	The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents.	Oximes	92-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-81
22437842-1	2012	The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents.	Oximes	92-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
22437842-4	2012	In part, marked differences in affinity and reactivity of the investigated oximes toward OP-inhibited human AChE were recorded.	Oximes	75-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
22561105-1	2012	Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment.	Oximes	146-152	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
22561105-1	2012	Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment.	Oximes	146-152	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-142
22649796-2	2012	However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents.	Oximes	87-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-128
22649796-2	2012	However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents.	Oximes	87-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134
22649796-3	2012	New oximes were mostly tested for their therapeutic efficacy by using different animal models and for their reactivating potency with AChE from different species.	Oximes	4-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
22649796-5	2012	Now, we found it tempting to determine the reactivation kinetics of a series of bispyridinium oximes bearing one or two oxime groups at different positions and having an oxybismethylene or a trimethylene linker under identical conditions with human AChE inhibited by structurally different OP.	Oximes	94-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	249-253
22649796-7	2012	Hence, these and previous data emphasize the necessity for thorough kinetic investigations of OP-oxime-AChE interactions and underline the difficulty to develop a broad spectrum oxime reactivator which is efficient against structurally different OP inhibitors.	Oximes	97-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-107
22343626-2	2012	Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro.	Oximes	31-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-150
23115436-6	2012	Following decontamination, depending on the severity of intoxication the administration of atropine to counteract muscarinic over-stimulation, and an oxime to reactivate acetyl cholinesterase are indicated.	Oximes	150-155	butyrylcholinesterase	Homo sapiens	177-191
22292814-0	2012	Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.	Oximes	97-102	polo like kinase 1	Homo sapiens	32-50
22292814-0	2012	Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.	Oximes	97-102	polo like kinase 1	Homo sapiens	52-56
22292814-1	2012	In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide PLHSpT using oxime-based post solid-phase peptide diversification of the N-terminal Pro residue.	Oximes	189-194	polo like kinase 1	Homo sapiens	60-78
22292814-1	2012	In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide PLHSpT using oxime-based post solid-phase peptide diversification of the N-terminal Pro residue.	Oximes	189-194	polo like kinase 1	Homo sapiens	80-84
22343626-6	2012	The enhanced intrinsic reactivity against the OP-AChE target combined with favorable pharmacokinetic properties resulted in great improvement of antidotal properties of RS194B compared with RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide.	Oximes	233-238	acetylcholinesterase	Mus musculus	49-53
22385173-7	2012	Analysis of solvation free energy indicates high solute polarization and dispersion energies of the oximes to be particularly critical for the tabun- inhibited mouse AChE, whereas lower values of these properties favor reactivation against other OP agents, such as soman, sarin and cyclosarin.	Oximes	100-106	acetylcholinesterase	Mus musculus	166-170
22230262-0	2012	Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase.	Oximes	45-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
22230262-1	2012	There is an ongoing debate whether oximes can effectively counteract the effects of organophosphorus compounds (OP) on brain acetylcholinesterase (AChE) activity and whether there are differences in the kinetic properties of brain and erythrocyte AChE.	Oximes	35-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-145
22230262-1	2012	There is an ongoing debate whether oximes can effectively counteract the effects of organophosphorus compounds (OP) on brain acetylcholinesterase (AChE) activity and whether there are differences in the kinetic properties of brain and erythrocyte AChE.	Oximes	35-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151
22230262-7	2012	These data support the view that AChE from different tissue has similar kinetic properties and that brain AChE is comparably susceptible toward reactivation by oximes.	Oximes	160-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
22160885-5	2012	Plasma cholinesterase activity was higher in animals receiving enzyme and oxime before the organophosphates than in the oxime-only pretreated groups.	Oximes	74-79	butyrylcholinesterase	Homo sapiens	7-21
22160885-5	2012	Plasma cholinesterase activity was higher in animals receiving enzyme and oxime before the organophosphates than in the oxime-only pretreated groups.	Oximes	120-125	butyrylcholinesterase	Homo sapiens	7-21
21998030-2	2012	Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the investigation of the kinetics of interactions between OP and oximes.	Oximes	180-186	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-41
22125290-1	2012	OBJECTIVES: Oximes such as pralidoxime (2-PAM) are essential antidotes for life-threatening organophosphate poisoning.	Oximes	12-18	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	42-45
22309910-1	2012	We earlier reported an in silico pharmacophore model for reactivation of oximes to tabun-inhibited AChE.	Oximes	73-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
22309910-2	2012	Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a rational strategy to discover non-oxime reactivators of DFP-inhibited AChE in this study.	Oximes	135-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
22309910-4	2012	The procedure led us to identify several potent non-oxime compounds that reactivate DFP-inhibited AChE.	Oximes	52-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
22447833-1	2012	Oxime HI-6 is an efficient reactivator of the acetylcholinesterase inhibited by organophosphorous nerve agents.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-66
22731788-1	2012	We have applied a theoretical methodology, previously developed to evaluate the association and kinetic reactivation constants of oximes, comparing theoretical data obtained for human acetylcholinesterase (HsAChE) with in vitro results from Mus musculus AChE (MmAChE) previously reported in the literature.	Oximes	130-136	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-204
22280363-5	2012	SAR around our focused library revealed a number of features, most notably the oxime functionality to be important to this selectivity.	Oximes	79-84	sarcosine dehydrogenase	Homo sapiens	0-3
22696932-2	2012	In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain.	Oximes	187-193	acetylcholinesterase	Rattus norvegicus	87-107
22696932-2	2012	In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain.	Oximes	187-192	acetylcholinesterase	Rattus norvegicus	87-107
22754334-5	2012	CYP83A1 mainly metabolizes the aliphatic oximes to form aliphatic glucosinolate and CYP83B1 mostly catalyzes aromatic oximes to synthesis corresponding substrates for aromatic and indolic glucosinolates.	Oximes	41-47	cytochrome P450 83A1	Brassica rapa	0-7
22754334-5	2012	CYP83A1 mainly metabolizes the aliphatic oximes to form aliphatic glucosinolate and CYP83B1 mostly catalyzes aromatic oximes to synthesis corresponding substrates for aromatic and indolic glucosinolates.	Oximes	41-47	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	84-91
22731788-1	2012	We have applied a theoretical methodology, previously developed to evaluate the association and kinetic reactivation constants of oximes, comparing theoretical data obtained for human acetylcholinesterase (HsAChE) with in vitro results from Mus musculus AChE (MmAChE) previously reported in the literature.	Oximes	130-136	acetylcholinesterase	Mus musculus	208-212
23038000-8	2012	The activation of MPO and increase in IL-1, IL-6, TNF-alpha and IFN-gamma levels induced by CdCl(2) were also reduced by oxime.	Oximes	121-126	myeloperoxidase	Mus musculus	18-21
23038000-8	2012	The activation of MPO and increase in IL-1, IL-6, TNF-alpha and IFN-gamma levels induced by CdCl(2) were also reduced by oxime.	Oximes	121-126	interleukin 1 complex	Mus musculus	38-42
23038000-8	2012	The activation of MPO and increase in IL-1, IL-6, TNF-alpha and IFN-gamma levels induced by CdCl(2) were also reduced by oxime.	Oximes	121-126	interleukin 6	Mus musculus	44-48
23038000-8	2012	The activation of MPO and increase in IL-1, IL-6, TNF-alpha and IFN-gamma levels induced by CdCl(2) were also reduced by oxime.	Oximes	121-126	tumor necrosis factor	Mus musculus	50-59
23038000-8	2012	The activation of MPO and increase in IL-1, IL-6, TNF-alpha and IFN-gamma levels induced by CdCl(2) were also reduced by oxime.	Oximes	121-126	interferon gamma	Mus musculus	64-73
23038000-9	2012	IL-10, which was reduced by cadmium, was restored by oxime administration.	Oximes	53-58	interleukin 10	Mus musculus	0-5
22360668-6	2012	The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6).	Oximes	70-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-187
22360668-6	2012	The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6).	Oximes	124-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-187
22360668-6	2012	The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6).	Oximes	70-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-187
22808117-0	2012	Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase.	Oximes	23-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-119
22808117-1	2012	Oxime drugs translocate through the 20 A active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds" (such as tabun) conjugation.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-82
22052741-5	2011	By incorporating artificial amino acids that carry an azide (Aha) or an alkyne (Plk) in their side chains, into ubiquitin (Ub) and PCNA, respectively, we were able to link the two proteins site-specifically by the Cu(I) -catalyzed azide-alkyne cycloaddition.	Oximes	61-64	proliferating cell nuclear antigen	Homo sapiens	131-135
21989207-3	2011	Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures.	Oximes	49-54	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	6-9
21989207-3	2011	Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures.	Oximes	49-54	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	73-76
21989207-3	2011	Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures.	Oximes	49-54	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	73-76
21989207-3	2011	Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures.	Oximes	49-54	acetylcholinesterase	Cavia porcellus	212-216
21799476-6	2011	Standard treatment involves the administration of intravenous atropine and an oxime to counteract acetylcholinesterase inhibition at the synapse, but the usefulness of oximes is still debated.	Oximes	78-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-118
21930118-1	2011	Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides.	Oximes	133-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-112
21723318-11	2011	This indicates that peripheral and central AChE activities are not necessarily correlated after the treatment of OP compounds and/or oximes, which should be taken into account in the diagnosis and management of OP-exposed humans.	Oximes	133-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-47
21983245-0	2011	Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study.	Oximes	21-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-68
21983245-0	2011	Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study.	Oximes	21-27	butyrylcholinesterase	Homo sapiens	73-94
21983245-2	2011	Oximes are compounds generally used to reverse the ChE inhibition caused by OP agents.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	51-54
21983245-3	2011	In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-212
21983245-3	2011	In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	214-218
21983245-3	2011	In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion.	Oximes	72-77	butyrylcholinesterase	Homo sapiens	224-245
21983245-3	2011	In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion.	Oximes	72-77	butyrylcholinesterase	Homo sapiens	247-251
21983245-8	2011	However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE.	Oximes	30-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
21983245-10	2011	We conclude that both newly developed oximes seem to be promising reactivators of OP-inhibited AChE.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
21930118-1	2011	Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides.	Oximes	133-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118
21504785-0	2011	Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase.	Oximes	55-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-134
21504785-2	2011	Conversely, non-ionic oxime reactivators often suffer from a lack of reactivating potency due to a low affinity for the active site of AChE.	Oximes	22-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
21726608-1	2011	The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes.	Oximes	107-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-144
21730071-5	2011	Here, we characterize 10 human (h) AChE mutants that, when coupled with an oxime, give rise to catalytic reactivation and aging resistance of the soman conjugate.	Oximes	75-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
21726608-1	2011	The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes.	Oximes	107-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
21726608-7	2011	In vitro testing of the nanoparticulate oxime formulations in primary porcine brain capillary endothelial cells (pBCEC) demonstrated an up to two times higher reactivation of OP-inhibited AChE than the free oximes.	Oximes	40-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-192
21803135-2	2011	To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE).	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96
21803135-2	2011	To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE).	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
21641693-3	2011	In addition, oxime Ih displayed cytotoxicity against KB cells with an IC(50) value of 0.17 muM which is about 10 times stronger than the ellipticine.	Oximes	13-18	latexin	Homo sapiens	91-94
21730071-0	2011	Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
21671403-0	2011	Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH.	Oximes	0-5	YopH	Yersinia pestis	148-152
21605992-2	2011	Oximes are used as potential reactivators of OP-inhibited AChE due to their alpha-effect nucleophilic reactivity.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
21524678-1	2011	The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical warfare (CW) organophosphorous (OP) nerve agent poisoning.	Oximes	4-10	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	26-29
21600273-3	2011	An explanation for limited penetration might be that oximes are substrates for the active P-glycoprotein (Pgp) efflux transporter located in the BBB.	Oximes	53-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	90-104
21600273-3	2011	An explanation for limited penetration might be that oximes are substrates for the active P-glycoprotein (Pgp) efflux transporter located in the BBB.	Oximes	53-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-109
21688786-2	2011	The reactions proceeded with both of anti- and syn-isomers of oximes with a wide scope of substituents.	Oximes	62-68	synemin	Homo sapiens	47-50
21530621-3	2011	Although successful treatment of OP poisoning can be obtained through decontamination and/or oxime reactivation of agent-inhibited cholinesterase, medical countermeasures that increase the therapeutic window for these measures would be of benefit.	Oximes	93-98	cholinesterase	Sus scrofa	131-145
21574642-5	2011	First, we identified an optimized oxime conjugation strategy under which complex dendrimers can be fully decorated not only with model peptides, but also with recombinant proteins (insulin was taken as an example).	Oximes	34-39	insulin	Homo sapiens	181-188
21493754-10	2011	Protein expression of ACHE nonsynonymous variant D134H (SNP6) is impaired: this variant shows compromised stability and altered rates of organophosphate inhibition and oxime-assisted reactivation.	Oximes	168-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
21464125-4	2011	Reactivation capacities of novel oximes are rank ordered by their relative reactivation rate constants at 0.67 mm compared with 2-pyridinealdoxime methiodide for reactivation of four organophosphate (sarin, cyclosarin, VX, and paraoxon) conjugates of human acetylcholinesterase (hAChE).	Oximes	33-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	279-284
21464125-6	2011	The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives (for hAChE) and imidazole-containing aldoximes (for hBChE) also exhibited reasonable activity in the reactivation of tabun conjugates.	Oximes	25-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-92
21464125-6	2011	The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives (for hAChE) and imidazole-containing aldoximes (for hBChE) also exhibited reasonable activity in the reactivation of tabun conjugates.	Oximes	25-31	butyrylcholinesterase	Homo sapiens	134-139
21195145-4	2011	Oxime-type AChE reactivators pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 were tested for their potential to affect the activity of monoamine oxidase of type A (MAO-A) and type B (MAO-B) in crude mitochondrial fraction of pig brains.	Oximes	0-5	acetylcholinesterase (Yt blood group)	Sus scrofa	11-15
21417297-6	2011	These somehow contradictory results were finally rationalized by a computational assisted SAR, which gave us the chance to understand how the oxime derivatives interact with the catalytic site and justify the observed activity profile.	Oximes	142-147	sarcosine dehydrogenase	Homo sapiens	90-93
21367426-3	2011	Results confirmed that (i) the TMS oxime-ether derivatives of the keto steroids provide from 1.40 times (gestodene) up to 4.25 times (norethisterone) higher responses compared to their TMS-ether ones, and (ii) the distribution of syn/anti oximes is characteristic to the ketosteroid species examined.	Oximes	35-40	synemin	Homo sapiens	230-233
20807085-1	2011	The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE).	Oximes	138-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	204-208
20807085-4	2011	These constants can be used to calculate reactivation velocities and oxime concentrations necessary for the reactivation of a desired fraction of inhibited AChE.	Oximes	69-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	156-160
20807085-7	2011	Hereby, it has to be taken into account that an increase of affinity to OP-inhibited AChE is generally accompanied by an increased affinity to native AChE and subsequent reduction in oxime tolerance.	Oximes	183-188	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
20807085-8	2011	Hence, future developments of more effective oximes should consider kinetic demands by attempting to achieve a certain level of reactivity and affinity, preferentially towards OP-inhibited AChE.	Oximes	45-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-193
21402092-2	2011	However, successful oxime treatment in soman poisoning is limited due to rapid aging of phosphylated acetylcholinesterase (AChE).	Oximes	20-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-121
21402092-2	2011	However, successful oxime treatment in soman poisoning is limited due to rapid aging of phosphylated acetylcholinesterase (AChE).	Oximes	20-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127
21195145-4	2011	Oxime-type AChE reactivators pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 were tested for their potential to affect the activity of monoamine oxidase of type A (MAO-A) and type B (MAO-B) in crude mitochondrial fraction of pig brains.	Oximes	0-5	monoamine oxidase A	Sus scrofa	143-170
21251822-0	2011	Non-oxime inhibitors of B-Raf(V600E) kinase.	Oximes	4-9	Braf transforming gene	Mus musculus	24-29
21328273-2	2011	Standard treatment involves administration of intravenous atropine and oxime to reactivate inhibited acetylcholinesterase.	Oximes	71-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-121
21080696-0	2010	Enantioselective conjugate addition of oximes to trisubstituted beta-nitroacrylates: an organocatalytic approach to beta(2,2)-amino acid derivatives.	Oximes	39-45	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	116-124
20569082-3	2011	The reactivation efficacy of the oximes was estimated on the rats exposed to tabun, atropine and a reactivator of AChE.	Oximes	33-39	acetylcholinesterase	Rattus norvegicus	114-118
20688148-3	2011	The oxime 3c exhibited 45% regeneration of inhibited hAChE, in comparison to 34% and 24% regeneration by 2-PAM and obidoxime, respectively, at a concentration of 10(-3) M within 10 min.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-58
20688148-6	2011	This method involving the in vitro reactivation of inhibited hAChE may be useful for the screening of new oximes as reactivators.	Oximes	106-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-66
21195611-2	2011	A novel series of oxime containing benzyl-1,3-dioxane-r-2-carboxylic acid derivatives (6a-k) were designed as selective PPARalpha agonists, through bioisosteric modification in the lipophilic tail region of PPARalpha/gamma dual agonist.	Oximes	18-23	peroxisome proliferator activated receptor alpha	Homo sapiens	120-129
21195611-2	2011	A novel series of oxime containing benzyl-1,3-dioxane-r-2-carboxylic acid derivatives (6a-k) were designed as selective PPARalpha agonists, through bioisosteric modification in the lipophilic tail region of PPARalpha/gamma dual agonist.	Oximes	18-23	peroxisome proliferator activated receptor alpha	Homo sapiens	207-216
21195611-6	2011	Together, these results confirm discovery of novel series of oxime based selective PPARalpha agonists for the safe and effective treatment of various metabolic disorders.	Oximes	61-66	peroxisome proliferator activated receptor alpha	Homo sapiens	83-92
21215640-0	2011	Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.	Oximes	35-40	peroxisome proliferator activated receptor alpha	Homo sapiens	57-61
21215640-0	2011	Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.	Oximes	35-40	peroxisome proliferator activated receptor alpha	Homo sapiens	125-129
21215640-5	2011	These results support our hypothesis that the introduction of structurally constrained oxime-ether linker between lipophilic tail and acidic head plays an important role in modulating subtype selectivity and subsequently led to the discovery of potent PPAR-pan agonists.	Oximes	87-92	peroxisome proliferator activated receptor alpha	Homo sapiens	252-256
21712782-2	2011	Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents).	Oximes	17-23	acetylcholinesterase (Yt blood group)	Sus scrofa	35-39
21117832-0	2011	The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.	Oximes	4-9	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	10-19
20971170-0	2011	Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.	Oximes	49-55	acetylcholinesterase	Cavia porcellus	117-137
20971170-1	2011	Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents.	Oximes	94-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-146
20971170-1	2011	Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents.	Oximes	94-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
21112787-0	2011	Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase.	Oximes	23-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	109-129
21954536-5	2011	Application of oxime reactivator enable return of AChE activity and full suppression of intoxication.	Oximes	15-20	acetylcholinesterase	Rattus norvegicus	50-54
21673941-0	2011	In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase.	Oximes	40-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
21673941-2	2011	We also tested reactivation of human butyrylcholinesterase (BChE) with the aim of finding a potent oxime, suitable to serve as a "pseudocatalytic" bioscavenger in combination with this enzyme.	Oximes	99-104	butyrylcholinesterase	Homo sapiens	60-64
21673941-6	2011	In the case of methamidophos-inhibited AChE, the lower oxime concentration (10(-5) M) had higher reactivation ability than the 10(-4) M concentration.	Oximes	55-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
21673941-7	2011	Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE.	Oximes	363-369	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
21151975-4	2010	The standard treatment of OP poisoning includes a combination of a muscarinic antagonist and an AChE reactivator (oxime).	Oximes	114-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-100
20888357-8	2010	Due to the high reactivity of MMB-4 a rapid reactivation of inhibited AChE can be anticipated at adequate oxime concentrations which are substantially higher compared to HI-6.	Oximes	106-111	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
21151975-8	2010	In general, the nanoparticulate transported oximes achieved a better reactivation of OP-inhibited AChE than free oximes.	Oximes	44-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
21151975-8	2010	In general, the nanoparticulate transported oximes achieved a better reactivation of OP-inhibited AChE than free oximes.	Oximes	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
20510679-12	2010	Finally, these data emphasize the need to develop oximes with a higher selective affinity towards OP-inhibited hAChE in order to minimize possible side effects.	Oximes	50-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-116
20655881-2	2010	Oxime compounds used in nerve agent antidote regimen reactivate nerve agent-inhibited AChE and halt the development of this cholinergic crisis.	Oximes	0-5	acetylcholinesterase	Bos taurus	86-90
20655881-4	2010	To understand the mechanism for the differential activities of oximes toward AChE inhibited by diverse nerve agents in order to aid the design of new broad-spectrum AChE reactivators, we undertook site-directed mutagenesis and molecular modeling studies.	Oximes	63-69	acetylcholinesterase	Bos taurus	77-81
20655881-4	2010	To understand the mechanism for the differential activities of oximes toward AChE inhibited by diverse nerve agents in order to aid the design of new broad-spectrum AChE reactivators, we undertook site-directed mutagenesis and molecular modeling studies.	Oximes	63-69	acetylcholinesterase	Bos taurus	165-169
20688049-11	2010	Imoproxifan bound to hH(3)R and rH(3)R in E-configuration, which represents the trans-isomer of the oxime-moiety as determined in crystallization studies, and stabilized active hH(3)R-, but inactive rH(3)R-conformations.	Oximes	100-105	histamine receptor H3	Homo sapiens	21-27
20635332-6	2010	It seems obvious that oximes are weakly penetrating the BBB, with minimal brain AChE reactivation (&lt;5%) in important functional areas, such as the ponto-medullar.	Oximes	22-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
19883634-8	2010	Also oxime therapy in organophosphorus poisoning apparently gives perplexing results: Oximes are usually able to reactivate diethylphosphorylated AChE, but the efficiency may be occasionally markedly smaller than expected from kinetic data.	Oximes	5-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
19883634-8	2010	Also oxime therapy in organophosphorus poisoning apparently gives perplexing results: Oximes are usually able to reactivate diethylphosphorylated AChE, but the efficiency may be occasionally markedly smaller than expected from kinetic data.	Oximes	86-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
19883634-9	2010	Dimethylphosphorylated AChE is in general less amenable to oxime therapy, which largely fails in some cases of dimethoate poisoning where aging was much faster than expected from a dimethylphosphorylated enzyme.	Oximes	59-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
19917271-2	2010	The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning.	Oximes	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
19917271-2	2010	The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning.	Oximes	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
19917271-2	2010	The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning.	Oximes	68-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
19917271-2	2010	The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning.	Oximes	68-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
19917271-5	2010	Kinetic studies on the various interactions between erythrocyte AChE from various species, structurally different OP and different oximes provided a basis for the initial assessment of the ability of oximes to reactivate inhibited AChE.	Oximes	200-206	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
19917271-5	2010	Kinetic studies on the various interactions between erythrocyte AChE from various species, structurally different OP and different oximes provided a basis for the initial assessment of the ability of oximes to reactivate inhibited AChE.	Oximes	200-206	acetylcholinesterase (Cartwright blood group)	Homo sapiens	231-235
19917271-6	2010	In the present study, in vitro enzyme-kinetic and pharmacokinetic data from a minipig model of dimethoate poisoning and oxime treatment were used to calculate dynamic changes of AChE activities.	Oximes	120-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-182
20156430-10	2010	However, blood and diaphragm showed similar AChE activities in animals treated with either oxime, as both 2-PAM and pro-2-PAM are PNS active oximes.	Oximes	91-96	acetylcholinesterase	Cavia porcellus	44-48
20206154-2	2010	This can be improved by creating a pseudo-catalytic scavenger adding oximes as reactivators of inhibited exogenous BChE.	Oximes	69-75	butyrylcholinesterase	Homo sapiens	115-119
20156430-10	2010	However, blood and diaphragm showed similar AChE activities in animals treated with either oxime, as both 2-PAM and pro-2-PAM are PNS active oximes.	Oximes	91-96	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	108-111
20156430-10	2010	However, blood and diaphragm showed similar AChE activities in animals treated with either oxime, as both 2-PAM and pro-2-PAM are PNS active oximes.	Oximes	91-96	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	116-125
20156430-10	2010	However, blood and diaphragm showed similar AChE activities in animals treated with either oxime, as both 2-PAM and pro-2-PAM are PNS active oximes.	Oximes	141-147	peptidyl-glycine alpha-amidating monooxygenase	Cavia porcellus	116-125
20206154-3	2010	In order to improve the BChE bioscavenging function in tabun or paraoxon poisoning, we tested in vitro reactivation of phosphorylated human plasma BChE by bispyridinium oximes varying in the length and type of the linker between rings, and in the position of the oxime group on the ring.	Oximes	169-174	butyrylcholinesterase	Homo sapiens	147-151
20167212-4	2010	Combination of both oximes showed potentiation of their reactivation efficacy; this potentiation was expressed for peripheral AChE (blood, diaphragm) and some parts of the brain (pontomedullar area, frontal cortex); AChE in the basal ganglia was relatively resistant.	Oximes	20-26	acetylcholinesterase	Rattus norvegicus	126-130
20206154-4	2010	Among the tested oximes, the most potent reactivators of tabun-inhibited BChE were K117 [1,1"-(2,2"-oxybis(ethane-2,1-diyl))bis(4-hydroxyiminomethyl pyridinium) bromide] and K127 [4-carbamoyl-1-(2-(2-(4-(hydroxyiminomethyl) pyridinium-1-yl)ethoxy)ethyl)pyridinium bromide].	Oximes	17-23	butyrylcholinesterase	Homo sapiens	73-77
20167212-4	2010	Combination of both oximes showed potentiation of their reactivation efficacy; this potentiation was expressed for peripheral AChE (blood, diaphragm) and some parts of the brain (pontomedullar area, frontal cortex); AChE in the basal ganglia was relatively resistant.	Oximes	20-26	acetylcholinesterase	Rattus norvegicus	216-220
20206154-7	2010	Using molecular mechanics, we performed docking of the oximes to tabun-inhibited BChE in order to discuss possible structural modifications of bispyridinium oximes to improve reactivation of phosphorylated BChE.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	81-85
20206154-7	2010	Using molecular mechanics, we performed docking of the oximes to tabun-inhibited BChE in order to discuss possible structural modifications of bispyridinium oximes to improve reactivation of phosphorylated BChE.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	206-210
20433814-5	2010	Current treatments for OP poisoning involve the administration of atropine, which blocks ACh receptors, and oximes, which reactivate AChE after inhibition.	Oximes	108-114	acetylcholinesterase	Cavia porcellus	133-137
20412789-0	2010	Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase.	Oximes	24-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
20433814-9	2010	Although guinea pigs historically have been used to test OP poisoning therapies, it has been found recently that guinea pig AChE is substantially more resistant to oxime-mediated reactivation than human AChE.	Oximes	164-169	acetylcholinesterase	Cavia porcellus	124-128
20412789-1	2010	Oximes are commonly used nucleophilic reactivators of alkyl phosphorylated and alkyl methylphosphonylated acetylcholinesterase (AChE) and butyrylcholinesterase.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
20433814-13	2010	To examine directly how these differences affect oxime-mediated reactivation of AChE after inhibition by OPs, human and guinea pig red blood cell ghosts were prepared and used as sources of AChE, and the relative capacity of several different oximes to reactivate each OP-inhibited AChE were determined.	Oximes	49-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
20412789-1	2010	Oximes are commonly used nucleophilic reactivators of alkyl phosphorylated and alkyl methylphosphonylated acetylcholinesterase (AChE) and butyrylcholinesterase.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
20600799-6	2010	Overall, the study reveals that the oxime 4P-2 may have therapeutic potential in the reactivation of human AChE inhibited by sarin.	Oximes	36-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111
20412789-3	2010	In this study we determined kinetic constants for interaction of three triazole containing oximes with native human AChE, enzyme diethylphosphorylated by paraoxon, enzyme phosphonylated by VX and cyclosarin as well as enzyme aged upon phosphonylation by soman.	Oximes	91-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
20412789-4	2010	Stopped-flow kinetics of oxime interaction was monitored using quenching of intrinsic tryptophan fluorescence of AChE as an indicator of oxime binding.	Oximes	25-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
20412789-4	2010	Stopped-flow kinetics of oxime interaction was monitored using quenching of intrinsic tryptophan fluorescence of AChE as an indicator of oxime binding.	Oximes	137-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
20417629-1	2010	Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)).	Oximes	93-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-42
20417629-1	2010	Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)).	Oximes	93-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-48
20417629-3	2010	Molecular modelling of AChE-oxime complexes was used to determine amino acid residues of the active site involved in the interactions.	Oximes	28-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
20417629-6	2010	The weakest inhibitor, K127, also formed several hydrogen bonds with the active site residues, but due to its long linker it was more likely stabilized at the peripheral site (Tyr124), which could explain lower AChE affinity for this oxime.	Oximes	234-239	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215
20406208-0	2010	In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase.	Oximes	62-68	acetylcholinesterase	Mus musculus	103-123
20406208-2	2010	Human malathion poisoning has been treated with oximes (mainly pralidoxime) in an attempt to reactivate OP-inhibited acetylcholinesterase (AChE).	Oximes	48-54	acetylcholinesterase	Mus musculus	117-137
20406208-2	2010	Human malathion poisoning has been treated with oximes (mainly pralidoxime) in an attempt to reactivate OP-inhibited acetylcholinesterase (AChE).	Oximes	48-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143
20406208-4	2010	In this study, we evaluated the in vitro potency of standards and newly developed oximes in reactivating malaoxon-inhibited AChE derived from mouse brain supernatants.	Oximes	82-88	acetylcholinesterase	Mus musculus	124-128
20623827-1	2010	The (1)H, (13)C and (15)N NMR studies have shown that the E and Z isomers of pyrrole-2-carbaldehyde oxime adopt preferable conformation with the syn orientation of the oxime group with respect to the pyrrole ring.	Oximes	100-105	synemin	Homo sapiens	145-148
20096273-1	2010	Oxime-induced reactivation of organophosphorus (OP) nerve agent-inhibited acetylcholinesterase (AChE) is a very important step for the treatment of nerve agent toxicity.	Oximes	0-5	acetylcholinesterase	Cavia porcellus	96-100
20096273-4	2010	Later these oximes were shown to rapidly reactivate GF- and VR-inhibited AChE as well.	Oximes	12-18	acetylcholinesterase	Cavia porcellus	73-77
20105433-5	2010	However, human AChE inhibited by certain OP is rather resistant to oxime-induced reactivation.	Oximes	67-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-19
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Oximes	71-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Oximes	71-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
20546883-5	2010	The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS.	Oximes	122-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	294-298
21152278-0	2010	Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.	Oximes	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-42
21152278-0	2010	Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.	Oximes	112-117	butyrylcholinesterase	Homo sapiens	47-68
21152278-1	2010	We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos.	Oximes	45-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
21152278-1	2010	We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos.	Oximes	45-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
21152278-3	2010	In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027.	Oximes	94-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
21152278-5	2010	The reactivation efficacy of tested oximes was lower in case of leptophos-oxon inhibited BChE.	Oximes	36-42	butyrylcholinesterase	Homo sapiens	89-93
20192902-0	2010	Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-128
20350805-0	2010	A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.	Oximes	8-13	YopH	Yersinia pestis	138-142
20202777-5	2010	Oxime-type compounds used as acetylcholinesterase (AChE, E.C.3.1.1.7) reactivators have been considered for the retention study.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-49
20202777-5	2010	Oxime-type compounds used as acetylcholinesterase (AChE, E.C.3.1.1.7) reactivators have been considered for the retention study.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
20405932-5	2010	The presence of the syn- and anti-isomers of oxime 8 obtained from 4 were characterized by solid-state NMR and variable-temperature NMR experiments in acetone-d(6).	Oximes	45-50	synemin	Homo sapiens	20-23
20156534-0	2010	Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon.	Oximes	21-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
20156534-1	2010	Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE).	Oximes	144-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	206-210
20156534-2	2010	A recently introduced dynamically working in vitro model with real-time determination of membrane-bound AChE activity was shown to be a very versatile and promising model to investigate oxime-induced reactivation kinetics of OP-inhibited enzyme.	Oximes	186-191	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
20156534-6	2010	In addition, the basic kinetic constants of inhibition, aging, spontaneous- and oxime-induced-reactivation of erythrocyte AChE from these species were determined with a standard static model.	Oximes	80-85	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-126
21787634-0	2010	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker.	Oximes	43-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
21787634-1	2010	Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) were tested for their potency to reactivate VX-inhibited AChE.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
20408892-7	2010	The ACh-induced enhancement in resistance to infection was abrogated by co-administration of an oxime which can reactivate AChE.	Oximes	96-101	acetylcholinesterase	Mus musculus	123-127
20929049-5	2010	Although new oximes that can reactivate both peripheral and cerebral AChE and other prophylactic agents such as human serum butyrylcholinesterase (Hu BChE), sodium bicarbonate, huperzine A (a reversible ChE inhibitor) with imidazenil (a GABAA receptor modulator) have been proved effective in animal models, systematic clinical trials in patients are warranted.	Oximes	13-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
20929049-5	2010	Although new oximes that can reactivate both peripheral and cerebral AChE and other prophylactic agents such as human serum butyrylcholinesterase (Hu BChE), sodium bicarbonate, huperzine A (a reversible ChE inhibitor) with imidazenil (a GABAA receptor modulator) have been proved effective in animal models, systematic clinical trials in patients are warranted.	Oximes	13-19	butyrylcholinesterase	Homo sapiens	124-145
20929049-5	2010	Although new oximes that can reactivate both peripheral and cerebral AChE and other prophylactic agents such as human serum butyrylcholinesterase (Hu BChE), sodium bicarbonate, huperzine A (a reversible ChE inhibitor) with imidazenil (a GABAA receptor modulator) have been proved effective in animal models, systematic clinical trials in patients are warranted.	Oximes	13-19	butyrylcholinesterase	Homo sapiens	150-154
20455239-3	2010	Selective oxidation of the sialic acid residues on the glycan chains of transferrin was followed by introduction of a terminal alkyne functionality through an oxime linkage.	Oximes	159-164	transferrin	Homo sapiens	72-83
20385200-0	2010	Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.	Oximes	106-112	acetylcholinesterase	Mus musculus	17-37
20385200-2	2010	To alleviate peripheral respiratory failure oximes, e.g. obidoxime and pralidoxime, are used to reactivate inhibited acetylcholinesterase (AChE) with the intention to restore the disturbed neuromuscular function.	Oximes	44-50	acetylcholinesterase	Mus musculus	117-137
20385200-2	2010	To alleviate peripheral respiratory failure oximes, e.g. obidoxime and pralidoxime, are used to reactivate inhibited acetylcholinesterase (AChE) with the intention to restore the disturbed neuromuscular function.	Oximes	44-50	acetylcholinesterase	Mus musculus	139-143
20347021-3	2010	Reactivators (oximes) of inhibited AChE are a mainstay of treatment.	Oximes	14-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
20402532-3	2010	We demonstrate that amide coupling is efficient for producing multilayer structures on -COOH-terminated SAMs, while oxime coupling is efficient for producing multilayer structures on -CHO-terminated SAMs.	Oximes	116-121	methionine adenosyltransferase 1A	Homo sapiens	199-203
20350805-1	2010	A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling.	Oximes	152-157	YopH	Yersinia pestis	36-40
20005727-2	2010	The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
19746406-2	2010	The ability of two combinations of oximes (HI-6 + obidoxime and HI-6 + K203) to reactivate tabun-inhibited acetylcholinesterase and reduce acute toxicity of tabun was compared with the reactivating and therapeutic efficacy of antidotal treatment involving single oxime (HI-6, obidoxime, K203) using in vivo methods.	Oximes	35-40	acetylcholinesterase	Rattus norvegicus	107-127
19746406-3	2010	Studies determining percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is higher than the reactivating efficacy of the most effective individual oxime in blood and diaphragm and comparable with the reactivating effects of the most effective individual oxime in brain.	Oximes	183-189	acetylcholinesterase	Rattus norvegicus	83-103
19746406-3	2010	Studies determining percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is higher than the reactivating efficacy of the most effective individual oxime in blood and diaphragm and comparable with the reactivating effects of the most effective individual oxime in brain.	Oximes	183-188	acetylcholinesterase	Rattus norvegicus	83-103
19746406-6	2010	Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings beneficial effects for the potency of antidotal treatment to reactivate tabun-inhibited acetylcholinesterase in rats and to reduce acute toxicity of tabun in mice.	Oximes	106-112	acetylcholinesterase	Rattus norvegicus	208-228
20004171-6	2010	OP-inhibited butyrylcholinesterase and acetylcholinesterase can be reactivated with oximes provided the OP has not aged.	Oximes	84-90	butyrylcholinesterase	Homo sapiens	13-34
20004171-6	2010	OP-inhibited butyrylcholinesterase and acetylcholinesterase can be reactivated with oximes provided the OP has not aged.	Oximes	84-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-59
20051531-8	2010	The addition of the neutral oxime 2,3-butanedione monoxime increases the rate of reactivation of hCE1 from sarin inhibition by more than 60-fold but has no effect on reactivation with the other agents examined.	Oximes	28-33	carboxylesterase 1	Homo sapiens	97-101
20151655-2	2010	Reaction of the oxime derived from 2-(oxo-cyclopentyl)acetic acid ethyl ester with 2,3-bis(phenylsulfonyl)-1,3-butadiene gives rise to a 7-oxa-1-azanorbornane cycloadduct in high yield.	Oximes	16-21	OXA1L mitochondrial inner membrane protein	Homo sapiens	139-144
20140002-8	2010	Our work supports the growing body of evidence that the efficacy of the drugs is due to the differential bindings of the oximes with AChE and can aid to the rational design of oxime drugs.	Oximes	121-127	acetylcholinesterase	Mus musculus	133-137
20140002-8	2010	Our work supports the growing body of evidence that the efficacy of the drugs is due to the differential bindings of the oximes with AChE and can aid to the rational design of oxime drugs.	Oximes	121-126	acetylcholinesterase	Mus musculus	133-137
20005727-2	2010	The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
20005727-7	2010	Interestingly, oximes with a heterocyclic linker inhibited AChE at higher concentration (10(-3)M), whereas their ability to reactivate was increased at lower concentrations (10(-4)M and 10(-5)M).	Oximes	15-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
20028185-3	2010	Inhibited AChE can be reactivated by oximes, antidotes for OP exposure.	Oximes	37-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-14
19945872-0	2010	Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.	Oximes	0-5	transient receptor potential cation channel subfamily A member 1	Homo sapiens	67-72
20028185-4	2010	However, OP intoxication caused by the nerve agent tabun (GA) is particularly resistant to oximes, which poorly reactivate GA-inhibited AChE.	Oximes	91-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-140
20028185-5	2010	In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes.	Oximes	286-292	acetylcholinesterase (Cartwright blood group)	Homo sapiens	168-172
20028185-5	2010	In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes.	Oximes	286-292	acetylcholinesterase (Cartwright blood group)	Homo sapiens	264-268
20028185-7	2010	Quantum chemical methods were sequentially used from semiempirical AM1 to hierarchical ab initio calculations to determine the stereoelectronic properties of nine oximes exhibiting affinity for binding to GA-inhibited AChE in vivo.	Oximes	163-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	218-222
20028185-10	2010	The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes.	Oximes	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
20345348-4	2010	It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE.	Oximes	163-168	acetylcholinesterase (Cartwright blood group)	Homo sapiens	204-208
20345348-5	2010	Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed.	Oximes	65-71	butyrylcholinesterase	Homo sapiens	17-31
19465093-1	2009	Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning.	Oximes	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
20028185-10	2010	The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes.	Oximes	233-239	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
20028185-11	2010	The model was found to be well-correlated (R = 0.9) with experimental oxime affinity for binding to GA-inhibited AChE.	Oximes	70-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
20028185-13	2010	These results provided the first predictive pharmacophore model of oxime affinity for binding toward GA-inhibited AChE.	Oximes	67-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118
20032868-0	2009	Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon.	Oximes	20-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
20032868-0	2009	Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon.	Oximes	20-26	butyrylcholinesterase	Homo sapiens	69-90
19761810-2	2009	Oximes, such as K027 and HLo-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
19761810-2	2009	Oximes, such as K027 and HLo-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-86
19835355-0	2009	Biomimetic synthesis of lispro insulin via a chemically synthesized "mini-proinsulin" prepared by oxime-forming ligation.	Oximes	98-103	insulin	Homo sapiens	31-38
19835355-0	2009	Biomimetic synthesis of lispro insulin via a chemically synthesized "mini-proinsulin" prepared by oxime-forming ligation.	Oximes	98-103	insulin	Homo sapiens	74-84
19835355-2	2009	We used oxime-forming chemical ligation to introduce a temporary "chemical tether" to link the N-terminal residue of the insulin A chain to the C-terminal residue of the insulin B chain; the tether enabled us to fold/form disulfides with high efficiency.	Oximes	8-13	insulin	Homo sapiens	121-128
19835355-2	2009	We used oxime-forming chemical ligation to introduce a temporary "chemical tether" to link the N-terminal residue of the insulin A chain to the C-terminal residue of the insulin B chain; the tether enabled us to fold/form disulfides with high efficiency.	Oximes	8-13	insulin	Homo sapiens	170-177
19737786-2	2009	This chemical structure affects their responsiveness to oxime-induced acetylcholinesterase (AChE) reactivation after poisoning.	Oximes	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96
21578527-2	2009	One- and two-dimensional (1)H and (13)C NMR spectra, as well as IR data, are in agreement with the presence of a ketoxime group at C-23.	Oximes	113-121	nucleolin	Homo sapiens	131-135
21578527-6	2009	The ketoxime is stabilized with the E configuration, avoiding steric hindrance between the oxime O atom and H atom at C-23.	Oximes	4-12	nucleolin	Homo sapiens	118-122
19680820-1	2010	The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4.	Oximes	31-37	acetylcholinesterase	Cavia porcellus	110-130
19680820-1	2010	The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4.	Oximes	31-37	acetylcholinesterase	Cavia porcellus	132-136
19680820-1	2010	The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4.	Oximes	262-268	acetylcholinesterase	Cavia porcellus	110-130
19680820-1	2010	The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4.	Oximes	262-268	acetylcholinesterase	Cavia porcellus	132-136
19680820-13	2010	Thus, tertiary oximes reactivated AChE in the brain, improved survival, and terminated seizures following GB intoxication.	Oximes	15-21	acetylcholinesterase	Cavia porcellus	34-38
20402654-6	2010	Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated.	Oximes	24-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
20402654-6	2010	Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated.	Oximes	24-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	268-272
19572551-5	2009	The use of an oxime linkage between the polyamide and an aromatic functionality on the C-terminus resulted in a approximately 20-fold increase in the potency of polyamides targeted to the androgen response element (ARE) in LNCaP cells by measuring AR-activated PSA expression.	Oximes	14-19	aminopeptidase puromycin sensitive	Homo sapiens	261-264
19642642-7	2009	Furthermore, the crystal structure of the ternary complex of the aged conjugate with 2-PAM revealed that the orientation of the oxime function does not permit nucleophilic attack on the phosphorus atom, thus providing a plausible explanation for its failure to reactivate the aged soman/AChE conjugate.	Oximes	128-133	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	87-90
19642642-7	2009	Furthermore, the crystal structure of the ternary complex of the aged conjugate with 2-PAM revealed that the orientation of the oxime function does not permit nucleophilic attack on the phosphorus atom, thus providing a plausible explanation for its failure to reactivate the aged soman/AChE conjugate.	Oximes	128-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	287-291
19465093-1	2009	Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
19465093-1	2009	Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
19338015-7	2009	The potency of oximes to reactivate brain AChE was lower due to the poor blood-brain barrier penetration of used compounds.	Oximes	15-21	acetylcholinesterase	Rattus norvegicus	42-46
19778238-3	2009	Oximes such as 2-PAM are used to reactivate OP-inhibited AChE so as to restore normal enzymatic function and serve as a true antidote.	Oximes	0-6	acetylcholinesterase	Cavia porcellus	57-61
19778238-4	2009	There are reports of non-enzymatic hydrolysis by oximes of acetylthiocholine in in vitro preparations in the widely used Ellman assay for AChE activity, which may confound the interpretation of AChE activity by producing elevated results.	Oximes	49-55	acetylcholinesterase	Cavia porcellus	138-142
19778238-4	2009	There are reports of non-enzymatic hydrolysis by oximes of acetylthiocholine in in vitro preparations in the widely used Ellman assay for AChE activity, which may confound the interpretation of AChE activity by producing elevated results.	Oximes	49-55	acetylcholinesterase	Cavia porcellus	194-198
19778238-5	2009	The purpose of this experiment was to determine if there is appreciable interference by therapeutic levels of oximes on the results of the Ellman assay in assessing AChE reactivation by oxime compounds in vivo.	Oximes	110-116	acetylcholinesterase	Cavia porcellus	165-169
19778238-5	2009	The purpose of this experiment was to determine if there is appreciable interference by therapeutic levels of oximes on the results of the Ellman assay in assessing AChE reactivation by oxime compounds in vivo.	Oximes	110-115	acetylcholinesterase	Cavia porcellus	165-169
19778238-7	2009	With appropriate dilution of samples prior to spectrophotometric assay, the Ellman assay is an acceptable method to measure in vivo oxime reactivation of inhibited AChE.	Oximes	132-137	acetylcholinesterase	Cavia porcellus	164-168
19778239-7	2009	These oximes exhibited differential potency in reactivating nerve agent-inhibited AChE in various peripheral tissues, but not AChE activity in the brain regions.	Oximes	6-12	acetylcholinesterase	Cavia porcellus	82-86
19778239-9	2009	AChE inhibited by sarin was the most and cyclosarin the least susceptible to oxime reactivation.	Oximes	77-82	acetylcholinesterase	Cavia porcellus	0-4
19482409-1	2009	We determine the binding mode of a macrocyclic radicicol-like oxime to yeast HSP90 by combining computer simulations and experimental measurements.	Oximes	62-67	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	77-82
19482409-6	2009	We find that the most likely binding mode of the oxime to yeast HSP90 is very similar to the known structure of the radicicol-HSP90 complex.	Oximes	49-54	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	64-69
19482409-6	2009	We find that the most likely binding mode of the oxime to yeast HSP90 is very similar to the known structure of the radicicol-HSP90 complex.	Oximes	49-54	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	126-131
19552519-2	2009	Studies determined percentage of reactivation of tabun-inhibited blood and tissue AChE in poisoned rats and showed that the reactivating efficacy of both newly developed oximes is comparable with the oxime HI-6 but it is significantly lower than the reactivating effects of obidoxime and trimedoxime, especially in diaphragm and brain.	Oximes	170-176	acetylcholinesterase	Rattus norvegicus	82-86
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	42-48	acetylcholinesterase	Rattus norvegicus	14-18
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	42-48	keratin 27	Rattus norvegicus	164-168
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	137-143	acetylcholinesterase	Rattus norvegicus	14-18
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	137-143	keratin 27	Rattus norvegicus	164-168
19586353-0	2009	In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-111
19621084-7	2009	Crystal structures of the TTR:inhibitor complexes, in agreement with molecular docking studies, revealed that the aromatic moiety, linked to the sp(2)-hybridized oxime carbon, specifically directed the ligand in either a forward or reverse binding mode.	Oximes	162-167	transthyretin	Homo sapiens	26-29
19586353-3	2009	METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds.	Oximes	41-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
19586353-3	2009	METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds.	Oximes	41-46	butyrylcholinesterase	Homo sapiens	188-209
18950608-1	2009	Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs).	Oximes	0-6	acetylcholinesterase	Mus musculus	51-71
19526299-2	2009	However, oximes themselves are also AChE inhibitors, albeit at higher concentrations, which is a major cause of their toxicity and may be a dose-limiting factor in oxime therapy.	Oximes	9-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
19526299-2	2009	However, oximes themselves are also AChE inhibitors, albeit at higher concentrations, which is a major cause of their toxicity and may be a dose-limiting factor in oxime therapy.	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
19449818-1	2009	Oximes have been used as reactivators for organophosphorus-inhibited acetylcholinesterase (AChE).	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
19449818-4	2009	We have concluded that oximes reactivate AChE by a three-step mechanism in opposition to the four-step processes of the other modeled nucleophiles.	Oximes	23-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
19449818-5	2009	In addition, our model suggests that oximes react with AChE in the deprotonated form (oximate).	Oximes	37-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59
19368529-4	2009	hBChE inhibited by phosphoramidates such as tabun displays a peculiar resistance to oxime-mediated reactivation.	Oximes	84-89	butyrylcholinesterase	Homo sapiens	0-5
19368529-11	2009	This study provides the structural basis to design new oximes capable of reactivating phosphoramidyl-hBChE conjugates after intoxication, notably when hBChE is used as pretreatment, or to design BChE-based catalytic bioscavengers.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	101-106
19368529-11	2009	This study provides the structural basis to design new oximes capable of reactivating phosphoramidyl-hBChE conjugates after intoxication, notably when hBChE is used as pretreatment, or to design BChE-based catalytic bioscavengers.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	151-156
19368529-11	2009	This study provides the structural basis to design new oximes capable of reactivating phosphoramidyl-hBChE conjugates after intoxication, notably when hBChE is used as pretreatment, or to design BChE-based catalytic bioscavengers.	Oximes	55-61	butyrylcholinesterase	Homo sapiens	102-106
19277015-2	2009	Here, we show that chemical conjugation of a synthetic oligosaccharide harboring mannose 6-phosphate (M6P) residues onto recombinant human acid alpha-glucosidase (rhGAA) via oxime chemistry significantly improved its affinity for the cation-independent mannose 6-phosphate receptor (CI-MPR) and subsequent uptake by muscle cells.	Oximes	174-179	insulin like growth factor 2 receptor	Homo sapiens	234-281
19277015-2	2009	Here, we show that chemical conjugation of a synthetic oligosaccharide harboring mannose 6-phosphate (M6P) residues onto recombinant human acid alpha-glucosidase (rhGAA) via oxime chemistry significantly improved its affinity for the cation-independent mannose 6-phosphate receptor (CI-MPR) and subsequent uptake by muscle cells.	Oximes	174-179	insulin like growth factor 2 receptor	Homo sapiens	283-289
19429253-1	2009	Previous kinetic studies investigating the interactions between human acetylcholinesterase (AChE), structurally different organophosphorus compounds (OP) and oximes did not reveal a conclusive structure-activity relationship of the different reactions.	Oximes	158-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-90
19429253-7	2009	Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime.	Oximes	51-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
19429253-9	2009	Unfortunately, no structure-activity relationship could be observed for the oxime-induced reactivation of inhibited AChE.	Oximes	76-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
19376700-6	2009	Based on the typical topology of synthetic PPAR agonists, we focused our design approach on using 4,4-dimethyl-1,2,3,4-tetrahydroquinoline as a novel cyclic scaffold with oxime and acidic head group structural variations.	Oximes	171-176	peroxisome proliferator activated receptor alpha	Homo sapiens	43-47
19428953-4	2009	For therapeutic monitoring of oxime treatment in OP poisoning, measurement of erythrocyte AChE is suitable because erythrocyte AChE is an easily accessible surrogate for synaptic AChE.	Oximes	30-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
19428953-6	2009	In contrast, determination of plasma butyrylcholinesterase (BChE) activity is in routine use for monitoring the benefit of oxime therapy.	Oximes	123-128	butyrylcholinesterase	Homo sapiens	37-58
19428953-6	2009	In contrast, determination of plasma butyrylcholinesterase (BChE) activity is in routine use for monitoring the benefit of oxime therapy.	Oximes	123-128	butyrylcholinesterase	Homo sapiens	60-64
19428953-10	2009	Furthermore, oxime-induced reactivation is too slow to accomplish a pseudo catalytic function, so that administered BChE may be merely effective as a stoichiometric scavenger.	Oximes	13-18	butyrylcholinesterase	Homo sapiens	116-120
19150463-5	2009	This implies that the main beneficial effect of oximes may result from reactivation of AChE activity in respiratory muscles rather than in the brain.	Oximes	48-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
19150463-7	2009	Albeit the concentration of oximes in the central nervous system is significantly lower than in the plasma, they do gain access into the brain and are able to reactivate inhibited local AChE.	Oximes	28-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
19150463-9	2009	In this review, we focus on the ability of oximes to act in the brain and protect the central nervous system from OP-induced injury, either by direct reactivation of AChE or by other pharmacological mechanisms.	Oximes	43-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-170
19428926-0	2009	Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.	Oximes	18-23	acetylcholinesterase	Cavia porcellus	96-116
19428926-0	2009	Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.	Oximes	18-23	acetylcholinesterase	Cavia porcellus	234-254
19428926-1	2009	Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme.	Oximes	186-191	acetylcholinesterase	Cavia porcellus	100-120
19428926-1	2009	Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme.	Oximes	186-191	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-126
19428926-7	2009	Hence, this dynamic model offers the possibility to investigate highly reproducible interactions between AChE, OP and oximes with human and animal AChE.	Oximes	118-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151
18950608-1	2009	Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs).	Oximes	0-6	acetylcholinesterase	Mus musculus	73-77
19544081-5	2009	A novel oxime, 1-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-yloxy]-2-chloro-phenyl}-3-ethyl-urea (JNJ-38158471), was identified as a potent and selective inhibitor of VEGFR-2.	Oximes	8-13	kinase insert domain protein receptor	Mus musculus	172-179
18686075-7	2009	RESULTS AND DISCUSSION: In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue acetylcholinesterase (AChE) in poisoned rats showed that the potency of both newly developed oximes (K206, K269) to reactivate cyclosarin-inhibited AChE is comparable with that of obidoxime in blood and diaphragm, but slightly higher than that of obidoxime in brain.	Oximes	204-210	acetylcholinesterase	Rattus norvegicus	133-137
18991751-7	2008	Correlations between the different in vitro and in vivo data available reveal that an oxime with a low in vitro AChE inhibitory activity (high IC(50)) is rather non-toxic and reduces DFP-induced mortality (low cumulative relative risk).	Oximes	86-91	acetylcholinesterase	Rattus norvegicus	112-116
18992260-9	2008	Moreover, oximes protected tryptophan residues of ApoB-100 in the early stage of LDL oxidation and during the subsequent propagation phase.	Oximes	10-16	apolipoprotein B	Homo sapiens	50-58
18608751-2	2008	Studies which determined percentage of reactivation of tabun-inhibited blood and tissue AChE in poisoned rats showed that the reactivating efficacy of both newly developed oximes is comparable with obidoxime and trimedoxime in blood but lower than the reactivating potency of trimedoxime and obidoxime in the diaphragm and brain.	Oximes	172-178	acetylcholinesterase	Rattus norvegicus	88-92
18608751-7	2008	Both newly developed oximes (K206, K269) are significantly more efficacious in reactivating tabun-inhibited AChE in rats and to eliminate lethal toxic effects of tabun in mice than the oxime HI-6 but their reactivating and therapeutic potency does not prevail over the effectiveness of currently available obidoxime and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.	Oximes	21-27	acetylcholinesterase	Rattus norvegicus	108-112
18975951-5	2008	The inhibition of ChEs by tabun and the subsequent aging reaction are of particular interest, because tabun-ChE conjugates display an extraordinary resistance toward most current oxime reactivators.	Oximes	179-184	butyrylcholinesterase	Homo sapiens	18-21
18975951-6	2008	We investigated the structural basis of oxime resistance for phosphoramidated ChE conjugates by determining the crystal structures of the non-aged and aged forms of hBChE inhibited by tabun, and by updating the refinement of non-aged and aged tabun-inhibited mouse AChE (mAChE).	Oximes	40-45	butyrylcholinesterase	Homo sapiens	78-81
18975951-6	2008	We investigated the structural basis of oxime resistance for phosphoramidated ChE conjugates by determining the crystal structures of the non-aged and aged forms of hBChE inhibited by tabun, and by updating the refinement of non-aged and aged tabun-inhibited mouse AChE (mAChE).	Oximes	40-45	butyrylcholinesterase	Homo sapiens	165-170
18975951-6	2008	We investigated the structural basis of oxime resistance for phosphoramidated ChE conjugates by determining the crystal structures of the non-aged and aged forms of hBChE inhibited by tabun, and by updating the refinement of non-aged and aged tabun-inhibited mouse AChE (mAChE).	Oximes	40-45	acetylcholinesterase	Mus musculus	265-269
18975951-13	2008	The reported 3D data will help in the design of new oximes capable of reactivating tabun-ChE conjugates.	Oximes	52-58	butyrylcholinesterase	Homo sapiens	89-92
18991751-8	2008	Oximes with a high in vitro AChE reactivation potency (high tan alpha) also have a high in vitro AChE inhibitory activity (low IC(50)) and have a low LD(50) in vivo, implying high toxicity.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	28-32
18991751-8	2008	Oximes with a high in vitro AChE reactivation potency (high tan alpha) also have a high in vitro AChE inhibitory activity (low IC(50)) and have a low LD(50) in vivo, implying high toxicity.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	97-101
18991751-9	2008	Less hydrophilic oximes have strong in vitro AChE inhibitory activity, are better in vitro AChE reactivators, but are also more toxic in vivo and are associated with a high cumulative risk of death after DFP exposure in rats, implying low in vivo efficacy.	Oximes	17-23	acetylcholinesterase	Rattus norvegicus	45-49
18991751-9	2008	Less hydrophilic oximes have strong in vitro AChE inhibitory activity, are better in vitro AChE reactivators, but are also more toxic in vivo and are associated with a high cumulative risk of death after DFP exposure in rats, implying low in vivo efficacy.	Oximes	17-23	acetylcholinesterase	Rattus norvegicus	91-95
18504554-1	2008	Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs).	Oximes	0-6	acetylcholinesterase	Mus musculus	61-81
18826205-2	2008	Most of the compounds possessing an oxime ether linker were more potent PPARgamma activators than the lead PPARalpha/gamma dual agonist, tesaglitazar in vitro.	Oximes	36-41	peroxisome proliferator activated receptor gamma	Mus musculus	72-81
18826205-3	2008	Compound 18, one of the derivatives with an oxime ether linker, was found to selectively transactivate PPARgamma (EC 50 = 0.028 microM) over PPARalpha (EC 50 = 7.22 microM) in vitro and lower blood glucose in db/ db mice more than muraglitazar after oral treatment for 11 days.	Oximes	44-49	peroxisome proliferator activated receptor gamma	Mus musculus	103-112
18504554-1	2008	Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs).	Oximes	0-6	acetylcholinesterase	Mus musculus	83-87
18548743-2	2008	However, AChE inhibition by oximes themselves (as quantified by their intrinsic IC50) is the major cause of oxime toxicity and the dose-limiting factor.	Oximes	28-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13
18548743-2	2008	However, AChE inhibition by oximes themselves (as quantified by their intrinsic IC50) is the major cause of oxime toxicity and the dose-limiting factor.	Oximes	28-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13
18548743-5	2008	Best protection was conferred by K-27, reducing the relative risk of death (RR) to 16% of control RR (P &lt; or = 0.05), which was statistically significantly better (P &lt; or = 0.05) than all other tested oximes, except obidoxime, K-53 and K-75.	Oximes	207-213	keratin 27	Homo sapiens	33-37
18855728-9	2008	The potency of all newly synthesized oximes to reactivate tabun-inhibited AChE is comparable with obidoxime with the exception of K074 that is significantly more efficacious in the brain.	Oximes	37-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
18547553-4	2008	These oximes inhibited AchE with inhibitory potency (IC(50)) ranging from 0.02 to 1.0 mM.	Oximes	6-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
18547553-6	2008	The protective potency (P(50)) of all oximes in human erythrocyte AChE inhibited by soman and tabun could not be determined.	Oximes	38-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
18547554-1	2008	The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with soman, tabun or cyclosarin at a lethal dose corresponding to their LD(50) value.	Oximes	31-37	acetylcholinesterase	Rattus norvegicus	130-150
18547554-1	2008	The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with soman, tabun or cyclosarin at a lethal dose corresponding to their LD(50) value.	Oximes	69-75	acetylcholinesterase	Rattus norvegicus	130-150
18547554-2	2008	In vivo determined percentage of reactivation of soman-inhibited blood and brain acetylcholinesterase in poisoned rats showed that only the oxime HI-6 was able to reactivate soman-inhibited acetylcholinesterase in the peripheral (blood) as well as central (brain) compartment.	Oximes	140-145	acetylcholinesterase	Rattus norvegicus	81-101
18547554-2	2008	In vivo determined percentage of reactivation of soman-inhibited blood and brain acetylcholinesterase in poisoned rats showed that only the oxime HI-6 was able to reactivate soman-inhibited acetylcholinesterase in the peripheral (blood) as well as central (brain) compartment.	Oximes	140-145	acetylcholinesterase	Rattus norvegicus	190-210
18617161-0	2008	Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.	Oximes	19-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-66
18501341-0	2008	Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-59
18501341-1	2008	One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes.	Oximes	125-131	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
18555982-2	2008	It has been demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited acetylcholinesterase (AChE).	Oximes	49-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
18555982-3	2008	If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans.	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
18555982-6	2008	Results indicate that oxime reactivation of all three monkey AChEs was very similar to human AChE.	Oximes	22-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
18565503-2	2008	The purpose of the present study was to evaluate new oxime antidotes to reactivate the inhibited AChE.	Oximes	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
18501341-3	2008	We tested oximes varying in the type of ring (pyridinium and/or imidazolium), the length and type of the linker between rings, and in the position of the oxime group on the ring to find more effective oximes to reactivate tabun-inhibited human erythrocyte AChE.	Oximes	201-207	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260
18523134-7	2008	Accordingly, oxime administration to PEG-F338A-AChE-pretreated mice enabled them to withstand repeated soman exposure (5.4 and 4 LD(50)/dose), whereas same regime treatment of non-PEGylated F338A-AChE- or PEGylated WT-AChE-pretreated mice failed to protect against the second challenge, due to rapid clearance or irreversible aging of the latter enzymes.	Oximes	13-18	acetylcholinesterase	Mus musculus	47-51
18501341-7	2008	Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE.	Oximes	39-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	232-236
18501341-7	2008	Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE.	Oximes	153-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	232-236
18523134-7	2008	Accordingly, oxime administration to PEG-F338A-AChE-pretreated mice enabled them to withstand repeated soman exposure (5.4 and 4 LD(50)/dose), whereas same regime treatment of non-PEGylated F338A-AChE- or PEGylated WT-AChE-pretreated mice failed to protect against the second challenge, due to rapid clearance or irreversible aging of the latter enzymes.	Oximes	13-18	acetylcholinesterase	Mus musculus	196-200
18523134-7	2008	Accordingly, oxime administration to PEG-F338A-AChE-pretreated mice enabled them to withstand repeated soman exposure (5.4 and 4 LD(50)/dose), whereas same regime treatment of non-PEGylated F338A-AChE- or PEGylated WT-AChE-pretreated mice failed to protect against the second challenge, due to rapid clearance or irreversible aging of the latter enzymes.	Oximes	13-18	acetylcholinesterase	Mus musculus	196-200
18508103-4	2008	Analysis of in vitro reactivation was conducted with second-order rate contants (k(r2)) for oxime reactivation of agent-inhibited acetylcholinesterase (AChE) from guinea pig erythrocytes.	Oximes	92-97	acetylcholinesterase	Cavia porcellus	152-156
18508103-7	2008	The decrease in oxime PR and k(r2) as the volume of the agent moiety conjugated to AChE increased was consistent with a steric hindrance mechanism.	Oximes	16-21	acetylcholinesterase	Cavia porcellus	83-87
18655064-0	2008	SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization.	Oximes	7-12	tumor susceptibility 101	Homo sapiens	58-64
18344198-1	2008	Oximes are enzyme reactivators used in treating poisoning with organophosphorus cholinesterase (AChE) inhibitors.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	80-94
18617161-3	2008	For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used.	Oximes	97-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
18617161-11	2008	From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE.	Oximes	75-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	154-158
18481153-7	2008	CONCLUSION: Site-specific 18F-labeled Affibody against HER2 has been synthesized via chemoselective oxime formation between an aminooxy-functionalized Affibody and 18F-fluorobenzaldehyde.	Oximes	100-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
18444657-2	2008	With this simple two-step procedure involving substitution with readily available TsNHOTBS and subsequent treatment with CsF, a range of oximes were prepared including the ones hardly preparable with conventional procedures.	Oximes	137-143	colony stimulating factor 2	Homo sapiens	121-124
18564794-3	2008	The morbidity and mortality with organophosphate poisoning is relatively high despite the use of atropine as specific antidotal therapy and oximes to reactivate acetylcholinesterase.	Oximes	140-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	161-181
18344198-1	2008	Oximes are enzyme reactivators used in treating poisoning with organophosphorus cholinesterase (AChE) inhibitors.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-100
18344198-2	2008	The oxime dose which can be safely administered is limited by the intrinsic toxicity of the substances such as their own AChE-inhibiting tendency.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
18413392-4	2008	METHODS: In this study, anti-HER2 monomeric and dimeric protein scaffold molecules [Z(HER2:477) and (Z(HER2:477))(2), respectively] were radiofluorinated at a reasonable radiochemical yield (13%-18%) by use of site-specific oxime chemistry.	Oximes	224-229	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
18281016-0	2008	Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods.	Oximes	11-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
18304715-1	2008	The efficacy of oxime treatment in soman poisoning is limited due to rapid aging of inhibited acetylcholinesterase (AChE).	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-114
18304715-1	2008	The efficacy of oxime treatment in soman poisoning is limited due to rapid aging of inhibited acetylcholinesterase (AChE).	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
18281016-2	2008	The treatment options in soman poisoning are very limited due to rapid aging of the inhibited acetylcholinesterase (AChE), when the enzyme species is considered as irreversibly inhibited and resistant towards reactivation by oximes.	Oximes	225-231	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-114
18281016-2	2008	The treatment options in soman poisoning are very limited due to rapid aging of the inhibited acetylcholinesterase (AChE), when the enzyme species is considered as irreversibly inhibited and resistant towards reactivation by oximes.	Oximes	225-231	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
18281016-6	2008	The question whether there is a possibility of an interaction between pre-treating carbamates and oximes at AChE arises.	Oximes	98-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
17914843-2	2007	1H NMR and fluorescence titrations revealed that receptors 2a and 2b, incorporating suitable positioned amine and oxime moieties, are able to form strong 1:1 complexes (Ka1 approximately 10(5) M-1) with dodecyl alpha- and beta-maltoside in chloroform solutions.	Oximes	114-119	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	169-172
18035420-0	2008	Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex.	Oximes	36-42	acetylcholinesterase	Mus musculus	77-97
17918908-4	2007	The ion/molecule reaction adduct and the oxime formed via its dehydration were observed using reactive DESI; the protonated and sodiated forms of the ionized steroid were also observed both in reactive DESI and in DESI performed without the added hydroxylamine reagent.	Oximes	41-46	desumoylating isopeptidase 2	Homo sapiens	103-107
17370251-2	2007	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	83-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
17370251-2	2007	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	83-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
17370251-2	2007	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	83-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
17370251-2	2007	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	83-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
17370251-4	2007	The prospective oxime HI 6 is a weak reactivator of tabun- and pesticide-inhibited AChE, while the established oxime obidoxime mainly lacks efficacy with cyclosarin-inhibited enzyme.	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
17964625-1	2008	To develop a new reactivator of inhibited acetylcholinesterase (AChE) that can easily penetrate the blood-brain barrier (BBB), BBB penetration of 6 known and novel pyridinealdoxime methiodide (PAM)-type oximes (alkylPAMs) with relatively high reactivation activities was examined by in vivo rat brain microdialysis with liquid chromatography-mass spectrometry (LC-MS/MS).	Oximes	203-209	acetylcholinesterase	Rattus norvegicus	42-62
17964625-1	2008	To develop a new reactivator of inhibited acetylcholinesterase (AChE) that can easily penetrate the blood-brain barrier (BBB), BBB penetration of 6 known and novel pyridinealdoxime methiodide (PAM)-type oximes (alkylPAMs) with relatively high reactivation activities was examined by in vivo rat brain microdialysis with liquid chromatography-mass spectrometry (LC-MS/MS).	Oximes	203-209	acetylcholinesterase	Rattus norvegicus	64-68
18054823-2	2008	OPs act primarily by inhibiting acetylcholinesterase (AChE), the standard treatment for which includes AChE reactivators (oximes) in combination with antimuscarinic drugs.	Oximes	122-128	acetylcholinesterase (Yt blood group)	Sus scrofa	32-52
18054823-2	2008	OPs act primarily by inhibiting acetylcholinesterase (AChE), the standard treatment for which includes AChE reactivators (oximes) in combination with antimuscarinic drugs.	Oximes	122-128	acetylcholinesterase (Yt blood group)	Sus scrofa	54-58
18054823-2	2008	OPs act primarily by inhibiting acetylcholinesterase (AChE), the standard treatment for which includes AChE reactivators (oximes) in combination with antimuscarinic drugs.	Oximes	122-128	acetylcholinesterase (Yt blood group)	Sus scrofa	103-107
17977518-0	2008	Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-91
17977518-1	2008	The purpose of these experiments was to compare oxime-induced reactivation rate constants of acetylcholinesterase from different human tissue sources inhibited by organophosphorus compounds.	Oximes	48-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113
18393843-10	2008	Oximes, by reactivating acetylcholinesterase, are important adjunct therapeutics in organophosphate poisoning.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-44
17869525-0	2007	New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase.	Oximes	4-9	acetylcholinesterase	Bos taurus	129-149
18220560-2	2007	The main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited AChE.	Oximes	154-160	butyrylcholinesterase	Homo sapiens	125-139
18220560-2	2007	The main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited AChE.	Oximes	154-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	185-189
18220560-9	2007	An universality of oximes able to reactivate AChE inhibited by all OP is questioned and therefore, needs of development of new oximes is underlined.	Oximes	19-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
17716616-0	2007	Limitation of the Ellman method: cholinesterase activity measurement in the presence of oximes.	Oximes	88-94	butyrylcholinesterase	Homo sapiens	33-47
17716616-3	2007	Oximes, reactivators of inhibited cholinesterase, are nucleophiles that also react with ATCh (oximolysis), producing thiocholine and (indirectly) TNB ion.	Oximes	0-6	butyrylcholinesterase	Homo sapiens	34-48
17900152-1	2007	The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning.	Oximes	73-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
17900152-4	2007	Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE.	Oximes	65-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-144
17900152-5	2007	If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans.	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
17900152-7	2007	Reactivation kinetic studies with five mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inhibited human AChE in most cases was faster than guinea pig AChE.	Oximes	64-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	133-137
17443135-2	2007	Clinical treatment of nerve-agent poisoning is to use oxime-based antidotes to reactivate the inhibited AChE.	Oximes	54-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
17913691-2	2007	Therapeutic strategies are directed to antagonise overstimulation of muscarinic receptors with atropine and to reactivate inhibited AChE with oximes.	Oximes	142-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	132-136
17913691-11	2007	Oxime administration can be stopped when AChE is aged completely, but has to be continued as long as poison is present in the body and reactivation is possible.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
17443135-4	2007	To design improved oximes, crystal structures of a tabun-conjugated AChE in complex with different oximes are needed to guide the structural modifications of known antidotes.	Oximes	19-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
17443135-4	2007	To design improved oximes, crystal structures of a tabun-conjugated AChE in complex with different oximes are needed to guide the structural modifications of known antidotes.	Oximes	99-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
17304644-2	2007	The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using methyl-paraoxon [dimethyl p-nitrophenyl phosphate; (methyl-POX)] as a cholinesterase inhibitor.	Oximes	63-68	butyrylcholinesterase	Rattus norvegicus	167-181
17309042-1	2007	In the search for new oximes with higher reactivation potency and a broader spectrum, K-27 and K-48, have recently been synthesized.	Oximes	22-28	keratin 27	Rattus norvegicus	86-90
17151865-4	2007	The comparison of the reaction rates of the three therapeutically used oximes (2-PAM, obidoxime, HI 6) with the respective OPC gave the highest rate for crotylsarin and cyclosarin with obidoxime and to a similar degree with HI 6, while in the case of VX the most reactive oxime was HI 6.	Oximes	71-77	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	81-84
17151865-4	2007	The comparison of the reaction rates of the three therapeutically used oximes (2-PAM, obidoxime, HI 6) with the respective OPC gave the highest rate for crotylsarin and cyclosarin with obidoxime and to a similar degree with HI 6, while in the case of VX the most reactive oxime was HI 6.	Oximes	71-76	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	81-84
17382909-3	2007	Reactivators (oximes) of inhibited AChE are a mainstay of treatment.	Oximes	14-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
17382909-4	2007	However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes.	Oximes	137-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-19
17382909-4	2007	However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes.	Oximes	240-246	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-19
17382909-6	2007	A clear structure-activity relationship of aging, spontaneous and oxime-induced reactivation kinetics could be determined with AChE inhibited by N-monoalkyl tabun analogues depending on the chain length of the N-alkyl residue.	Oximes	66-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
17383875-4	2007	Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE.	Oximes	13-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
17674811-1	2007	The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with tabun or cyclosarin at a lethal dose corresponding to the LD50 value.	Oximes	31-37	acetylcholinesterase	Rattus norvegicus	130-150
17674811-1	2007	The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with tabun or cyclosarin at a lethal dose corresponding to the LD50 value.	Oximes	69-75	acetylcholinesterase	Rattus norvegicus	130-150
17674811-3	2007	On the other hand, one of the newly developed oximes (K074) seems to be a significantly more efficacious reactivator of tabun-inhibited acetylcholinesterase in the central compartment (brain) than the other studied oximes.	Oximes	46-52	acetylcholinesterase	Rattus norvegicus	136-156
17504181-3	2007	Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-75
17504181-3	2007	Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
17504181-9	2007	An universality of oximes able to reactivate AChE inhibited by all OP is questioned and trends (molecular modelling using neural network, structure-activity relationship, combination of reactivation and anticholinergic properties in one molecule) for future research are characterized.	Oximes	19-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
16904809-2	2007	OP inhibit acetylcholinesterase (AChE) and therefore standard treatment of respective poisoning includes AChE reactivators (oximes) in combination with antimuscarinic agents.	Oximes	124-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
17402711-2	2007	The formed AChE-OP conjugate subsequently undergoes an elimination reaction, termed aging, that results in an enzyme completely resistant to oxime-mediated reactivation by medical antidotes.	Oximes	141-146	acetylcholinesterase	Mus musculus	11-15
16904807-2	2007	Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness.	Oximes	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
16904807-2	2007	Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness.	Oximes	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
16904807-5	2007	Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes, human erythrocyte AChE can be exploited to test the efficacy of new oximes.	Oximes	92-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
16904807-6	2007	Recently, a dynamic computer model was developed which allows the calculation of AChE activities at different scenarios by combining enzyme kinetics (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics.	Oximes	210-215	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
16904807-9	2007	The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment.	Oximes	95-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
16904807-9	2007	The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment.	Oximes	164-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
16904807-9	2007	The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment.	Oximes	164-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
16904808-2	2007	Presently, standard treatment includes administration of an antimuscarinic agent (e.g. atropine) and a reactivator of inhibited AChE (oxime), but is considered to be rather ineffective with certain nerve agents due to low oxime effectiveness of the currently available oximes, obidoxime and pralidoxime.	Oximes	134-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
16904808-5	2007	A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments.	Oximes	153-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
16904808-5	2007	A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments.	Oximes	198-203	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
16904808-6	2007	The model is based on a combination of enzyme kinetics (inhibition, reactivation, aging) of AChE with OP, toxicokinetics and oxime pharmacokinetics.	Oximes	125-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96
16904808-8	2007	Due to a low affinity of HI 6 with VR-inhibited pig AChE the oxime dose that causes maximal reactivation of VR-inhibited pig AChE is conspicuously higher compared to humans.	Oximes	61-66	acetylcholinesterase	Sus scrofa	52-56
16904808-8	2007	Due to a low affinity of HI 6 with VR-inhibited pig AChE the oxime dose that causes maximal reactivation of VR-inhibited pig AChE is conspicuously higher compared to humans.	Oximes	61-66	acetylcholinesterase	Sus scrofa	125-129
17046138-0	2007	Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates.	Oximes	44-49	acetylcholinesterase	Mus musculus	12-32
17046138-1	2007	Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate.	Oximes	168-173	acetylcholinesterase	Mus musculus	24-44
17046138-1	2007	Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate.	Oximes	168-173	acetylcholinesterase	Mus musculus	46-50
17196318-2	2007	We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation.	Oximes	108-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
17196318-2	2007	We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation.	Oximes	108-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-46
17196318-4	2007	Accordingly, "Oxime-assisted Catalysis" by AChE provides a potential means for catalyzing the hydrolysis of organophosphates in plasma prior to their reaching the cellular target site.	Oximes	14-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-47
17010492-10	2007	This oxime concentration reactivated RBC-AChE&gt;20% of normal in most cases of OP poisoning by diethylphosphoryl compounds within a few hours.	Oximes	5-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
16904809-5	2007	Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime.	Oximes	57-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
16904809-5	2007	Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime.	Oximes	57-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
16904809-10	2007	In contrast, no structure-activity dependence could be observed for the oxime-induced reactivation of AChE and BChE inhibited by the compounds tested.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-106
16904809-10	2007	In contrast, no structure-activity dependence could be observed for the oxime-induced reactivation of AChE and BChE inhibited by the compounds tested.	Oximes	72-77	butyrylcholinesterase	Homo sapiens	111-115
16904809-11	2007	In general, OP-inhibited AChE and BChE were susceptible towards reactivation by oximes.	Oximes	80-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-29
16904809-11	2007	In general, OP-inhibited AChE and BChE were susceptible towards reactivation by oximes.	Oximes	80-86	butyrylcholinesterase	Homo sapiens	34-38
16962227-4	2007	All oximes inhibited human AChE reversibly, and the inhibition potency increased in the following order Py-4-Br&lt;Py-4-Cl&lt;Py-4-CH(3)&lt;Py-4-H&lt;Py-4-NO(2).	Oximes	4-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-31
16962227-5	2007	Although oximes Py-4-H and Py-4-NO(2) did not show significant reactivation ability, these oximes might be of interest as pre-treatment drugs due to their high affinity for the native AChE.	Oximes	91-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-188
16962227-7	2007	The orientations of all studied oximes in the active site of human AChE have been proposed by flexible ligand docking with AutoDock 3.0.	Oximes	32-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
17112559-3	2007	Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents, e.g. soman and cyclosarin.	Oximes	14-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
17298091-0	2007	Oxime-induced reactivation of sarin-inhibited AChE: a theoretical mechanisms study.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
17298091-3	2007	The potential energy surface along the pathway of the reactivation reaction of sarin-inhibited AChE by oxime reveals that the reaction can occur quickly due to the relatively low energy barriers.	Oximes	103-108	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
17335104-1	2007	Some oxime ether-substituted aryloxypropanolamines 3-5, structurally related to the active metabolite 2 of sarpogrelate 1, were synthesized and tested for their affinities at 5-HT2A and 5-HT1A serotoninergic receptors as well as at the alpha1-adrenoceptor.	Oximes	5-10	5-hydroxytryptamine receptor 2A	Homo sapiens	175-181
17456837-6	2007	Oximes, as a part of antidotal therapy, ensure the recovery of phosphylated enzymes via a process denoted as reactivation of inhibited AChE.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
17456837-11	2007	An oxime HLo-7 seems to be an efficient reactivator of AChE inhibited by any of the four organophosphorus warfare agents.	Oximes	3-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59
17456837-12	2007	According to the available literature, the oximes LuH-6 and TMB-4, although relatively toxic, are the most potent to induce reactivation of AChE inhibited by the majority of organophosphorus pesticides.	Oximes	43-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-144
17265452-0	2007	In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon.	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-66
17265452-15	2007	The ranking of reactivator potencies of the examined oximes determined with methyl-POX as an inhibitor (K-27 = K-48 &gt; K-33 &gt; pralidoxime &gt; methoxime) is similar to the ranking previously reported by us using POX as an inhibitor (K-27 &gt; or = K-48 &gt; K-33 &gt; methoxime = pralidoxime).	Oximes	53-59	keratin 27	Homo sapiens	238-242
17112559-5	2007	Reactivation of OP-inhibited AChE is considered to be the most important reaction of oximes.	Oximes	85-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
17112559-6	2007	Clinical data from studies with pesticide-poisoned patients support the assumption that the various reactions between AChE, OP and oxime, i.e. inhibition, reactivation and aging, can be investigated in vitro with human AChE.	Oximes	131-136	acetylcholinesterase (Cartwright blood group)	Homo sapiens	219-223
18254274-0	2007	Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).	Oximes	31-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
17188490-4	2007	An X-ray co-crystal of structure 11 revealed that the oxime moiety was mimicking the C-ring of genistein, as previously predicted by SAR and docking studies.	Oximes	54-59	sarcosine dehydrogenase	Homo sapiens	133-136
17370870-2	2007	Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifically.	Oximes	72-78	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	102-105
17126503-0	2007	Cholinesterase pseudo-activity, oximolysis, esterolysis, thiocholine ester hydrolysis by oximes: what"s in a name?	Oximes	89-95	butyrylcholinesterase	Homo sapiens	0-14
16971069-7	2006	All of these oximes showed esterase-like activity, and their strengths were consistent with those of known reactivators of inhibited AChE.	Oximes	13-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	133-137
17265677-0	2006	Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase.	Oximes	27-33	acetylcholinesterase	Rattus norvegicus	93-113
17265677-7	2006	In case of chlorpyrifos, TO231 was the most potent AChE reactivator with an 82 % reactivation at 1.0 mmol L(-1) oxime concentration.	Oximes	112-117	acetylcholinesterase	Rattus norvegicus	51-55
16904331-5	2006	Further in vivo studies employing a rat carrageenan-induced paw edema model showed that the oxime compounds (17a, 18a) were more potent anti-inflammatory agents than the 5-LOX inhibitor caffeic acid, and 15-LOX inhibitor nordihydroguaiaretic acid (NDGA), but less potent than the selective COX-2 inhibitor celecoxib.	Oximes	92-97	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	290-295
16979339-2	2006	With a 4-fluoro-2-methylindol-5-yloxy group at the 6-position and alkyl groups as the oxime side chains, many analogues showed good potency for VEGFR-2.	Oximes	86-91	kinase insert domain receptor	Homo sapiens	144-151
17252938-1	2006	Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes.	Oximes	196-202	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-156
17252938-1	2006	Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes.	Oximes	196-202	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-162
18072133-0	2006	Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.	Oximes	69-74	acetylcholinesterase (Yt blood group)	Sus scrofa	42-62
18072133-2	2006	AChE reactivators (also known as oximes) are generally used for the reactivation of an inhibited enzyme.	Oximes	33-39	acetylcholinesterase (Yt blood group)	Sus scrofa	0-4
18072133-6	2006	However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower).	Oximes	9-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
16982122-5	2006	In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7).	Oximes	159-165	butyrylcholinesterase	Homo sapiens	42-46
16982122-5	2006	In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7).	Oximes	159-165	acetylcholinesterase (Cartwright blood group)	Homo sapiens	185-189
16982122-5	2006	In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7).	Oximes	159-165	butyrylcholinesterase	Homo sapiens	315-319
16982122-5	2006	In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7).	Oximes	159-165	acetylcholinesterase (Cartwright blood group)	Homo sapiens	415-419
16982122-7	2006	The reactivation of tabun-inhibited BChE by oximes was very slow, and BChE binding affinity for oximes was lower than AChE"s.	Oximes	44-50	butyrylcholinesterase	Homo sapiens	36-40
16982122-8	2006	Therefore, BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AChE or protection of AChE by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
16982122-8	2006	Therefore, BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AChE or protection of AChE by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes.	Oximes	72-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
16982122-8	2006	Therefore, BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AChE or protection of AChE by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes.	Oximes	72-77	butyrylcholinesterase	Homo sapiens	232-236
16919943-1	2006	A series of multi-substituted oximes were prepared and their potencies for inhibiting lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity were evaluated in vitro.	Oximes	30-36	phospholipase A2 group VII	Homo sapiens	86-127
16919943-1	2006	A series of multi-substituted oximes were prepared and their potencies for inhibiting lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity were evaluated in vitro.	Oximes	30-36	phospholipase A2 group VII	Homo sapiens	129-138
16690067-1	2006	A simple and reliable HPLC method for the determination of the plasma level of K-27, an oxime type antidote of use in organophosphorus poisoning is presented.	Oximes	88-93	keratin 27	Rattus norvegicus	79-83
16876764-2	2006	The inhibited AChE may be reactivated by certain oximes as antidotes for clinical treatment of OP-intoxications.	Oximes	49-55	acetylcholinesterase	Mus musculus	14-18
16876764-3	2006	Crystal structures of the oximes HI-6, Ortho-7 and obidoxime in complex with Mus musculus acetylcholinesterase (mAChE) reveal different roles of the peripheral anionic site (PAS) in the binding of the oximes.	Oximes	26-32	acetylcholinesterase	Mus musculus	90-110
16876764-3	2006	Crystal structures of the oximes HI-6, Ortho-7 and obidoxime in complex with Mus musculus acetylcholinesterase (mAChE) reveal different roles of the peripheral anionic site (PAS) in the binding of the oximes.	Oximes	201-207	acetylcholinesterase	Mus musculus	90-110
16766478-2	2006	Both H oximes (HI-6, HLo-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime.	Oximes	7-12	acetylcholinesterase	Rattus norvegicus	110-130
17194020-8	2006	Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications.	Oximes	97-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
17194020-8	2006	Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications.	Oximes	97-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
17194021-6	2006	Furthermore effects of two conventional oximes paralidoxime (A) and obidoxime (B) on reactivation of the inhibited hAChE were studied but low reactivity was shown by both the oximes.	Oximes	40-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-120
16952906-1	2006	The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating tabun-inhibited acetylcholinesterase (AChE) and in eliminating tabun-induced acute toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.	Oximes	56-62	acetylcholinesterase	Rattus norvegicus	108-128
16952906-1	2006	The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating tabun-inhibited acetylcholinesterase (AChE) and in eliminating tabun-induced acute toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.	Oximes	56-62	acetylcholinesterase	Rattus norvegicus	130-134
16952906-1	2006	The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating tabun-inhibited acetylcholinesterase (AChE) and in eliminating tabun-induced acute toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.	Oximes	56-61	acetylcholinesterase	Rattus norvegicus	108-128
16952906-1	2006	The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating tabun-inhibited acetylcholinesterase (AChE) and in eliminating tabun-induced acute toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.	Oximes	56-61	acetylcholinesterase	Rattus norvegicus	130-134
16952906-5	2006	In addition, our results confirm that the efficacy of oximes in reactivating tabun-inhibited AChE in blood, diaphragm, and brain correlates with the potency of oximes in protecting rats poisoned with supralethal doses of tabun.	Oximes	54-60	acetylcholinesterase	Rattus norvegicus	93-97
16720069-2	2006	OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with antimuscarinic agents.	Oximes	98-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
16720069-9	2006	The potency of the investigated oximes was remarkably lower with OP-inhibited pig AChE.	Oximes	32-38	acetylcholinesterase (Yt blood group)	Sus scrofa	82-86
16740352-2	2006	Presently, standard treatment of poisoning by OP includes administration of atropine as an antimuscarinic agent and of oximes, e.g. obidoxime or pralidoxime, as reactivators of OP-inhibited acetylcholinesterase (AChE), but is considered to be rather ineffective with certain nerve agents.	Oximes	119-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	212-216
16740352-4	2006	A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning.	Oximes	125-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
16740352-4	2006	A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning.	Oximes	252-257	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
16740352-4	2006	A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning.	Oximes	252-257	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
16740352-4	2006	A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning.	Oximes	252-257	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
16740352-4	2006	A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning.	Oximes	252-257	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
16644174-2	2006	In the event of poisoning, a combination of three drugs is commonly used: an anticholinergic drug (e.g. atropine), an oxime used as cholinesterase reactivator (e.g. pralidoxime or HI-6) and an anticonvulsant (i.e. benzodiazepine).	Oximes	118-123	butyrylcholinesterase	Homo sapiens	132-146
16913699-7	2006	Our results suggest that the oximes provide a novel structural linker for 4-arylpiperazine-based D4 agonists, possessing leadlike quality and with potential to develop a new class of potent and selective dopamine D4 receptor agonists.	Oximes	29-35	dopamine receptor D4	Rattus norvegicus	204-224
16515465-5	2006	Anticholinergic drugs block effects of accumulated neurotransmitter acetylcholine at nicotinic and muscarinic receptor sites, while oximes reactivate AChE inhibited by OPCs.	Oximes	132-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
16782588-3	2006	The pharmacological action of oximes is multiple: they are able to reactivate the inhibited AChE, but they affect acetylcholine release in peripheral and central cholinergic synapses, allosterically modulate the muscarinic receptors in peripheral and central synapses, and influence the nicotinic receptor-associated ion-channels.	Oximes	30-36	acetylcholinesterase	Mus musculus	92-96
16522109-2	2006	The one-pot sequential reaction was conducted on a surface of human carbonic anhydrase II (hCAII) based on the affinity labeling and the subsequent hydrazone/oxime exchange reaction.	Oximes	158-163	carbonic anhydrase 2	Homo sapiens	68-89
16522109-2	2006	The one-pot sequential reaction was conducted on a surface of human carbonic anhydrase II (hCAII) based on the affinity labeling and the subsequent hydrazone/oxime exchange reaction.	Oximes	158-163	carbonic anhydrase 2	Homo sapiens	91-96
16583462-5	2006	Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27).	Oximes	80-86	keratin 27	Rattus norvegicus	303-307
16583462-5	2006	Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27).	Oximes	80-85	keratin 27	Rattus norvegicus	303-307
16598855-2	2006	The inhibition enzyme-oxime dissociation constants of AChE w.t.	Oximes	22-27	acetylcholinesterase	Mus musculus	54-58
16598855-6	2006	A high extent of oxime-assisted reactivation of all conjugates was achieved, but rates by both oximes were up to 10 times slower for phosphorylated mutants than for AChE w.t.	Oximes	17-22	acetylcholinesterase	Mus musculus	165-169
16623863-3	2006	Oximes counteract acetylcholine increase, resulting from AChE inhibition.	Oximes	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
16623863-6	2006	The usefulness of oxime in the reactivation process depends on its chemical structure and on the nerve agent whereby AChE is inhibited.	Oximes	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	117-121
16515465-7	2006	Therefore, to find new oximes able to sufficiently reactivate inhibited AChE (regardless of the type of OPCs) is still very important task for medicinal chemistry with the aim to improve the efficacy of antidotal treatment of the acute poisonings mentioned.	Oximes	23-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
17438836-0	2006	Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes.	Oximes	117-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
16332406-4	2006	All the oximes reversibly inhibited AChE, and the enzyme-oxime dissociation constants were between 17 and 180 microM.	Oximes	8-14	acetylcholinesterase	Mus musculus	36-40
16332406-4	2006	All the oximes reversibly inhibited AChE, and the enzyme-oxime dissociation constants were between 17 and 180 microM.	Oximes	8-13	acetylcholinesterase	Mus musculus	36-40
16332406-7	2006	Soman-inhibited AChE was resistant to reactivation by 1mM oximes.	Oximes	58-64	acetylcholinesterase	Mus musculus	16-20
16332406-8	2006	All studied oximes protected AChE from phosphorylation with both soman and tabun.	Oximes	12-18	acetylcholinesterase	Mus musculus	29-33
16393932-3	2005	In this study of cyclosarin poisoning treatment, oximes of different chemical structures (obidoxime, HI-6, BI-6, and HS-6) were tested in vitro on rat brain acetylcholinesterase (enzyme source: rat brain homogenate), and afterwards, they were tested in vivo in equimolar doses, in mice and rats.	Oximes	49-55	acetylcholinesterase	Rattus norvegicus	157-177
17438836-6	2006	From obtained results, it can be deduced, that only reactivators with oxime group in position two are able to reactivate cyclosarin-inhibited AChE.	Oximes	70-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
16193529-0	2006	Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon.	Oximes	5-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
16193529-8	2006	The purpose of the study was to quantify in vitro the extent of oxime (pralidoxime, K-27, K-33, K-48, methoxime and BI-6) conferred protection, using paraoxon as an inhibitor.	Oximes	64-69	keratin 27	Homo sapiens	84-88
17192653-2	2006	Presently, a combination of an antimuscarinic agent, e.g., atropine, and an AChE reactivator, oxime, is used for the treatment of organophosphorus compound poisoning.	Oximes	94-99	acetylcholinesterase	Mus musculus	76-80
16038577-4	2006	Correlation of the relative conversion of the oximes with Hammett parameters shows that radical effects dominate for the meta-substituted acetophenone oximes (rho(rad)/rho(pol) = 5.4; r2 = 0.93), whereas the para-substituted oximes are influenced almost equally by radical and ionic effects (rho(rad)/rho(pol) = -1.1; r2 = 0.98).	Oximes	46-52	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	88-91
16038577-4	2006	Correlation of the relative conversion of the oximes with Hammett parameters shows that radical effects dominate for the meta-substituted acetophenone oximes (rho(rad)/rho(pol) = 5.4; r2 = 0.93), whereas the para-substituted oximes are influenced almost equally by radical and ionic effects (rho(rad)/rho(pol) = -1.1; r2 = 0.98).	Oximes	46-52	rhodopsin	Homo sapiens	292-316
17288495-1	2006	The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a reactivator of inhibited acetylcholinesterase (AChE), which contains a nucleophilic oxime function.	Oximes	256-261	acetylcholinesterase (Cartwright blood group)	Homo sapiens	197-217
17288495-1	2006	The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a reactivator of inhibited acetylcholinesterase (AChE), which contains a nucleophilic oxime function.	Oximes	256-261	acetylcholinesterase (Cartwright blood group)	Homo sapiens	219-223
17288500-13	2006	As a result, it is important that an oxime is administered as soon after soman exposure as possible so that some reactivation of AChE occurs before all the enzyme becomes aged.	Oximes	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
16263103-7	2005	Accordingly, RBC-AChE appears to be a suitable parameter for judgment of oxime effectiveness at the neuromuscular junction, one of the most important targets for therapy where atropine is ineffective in OP-poisoning.	Oximes	73-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	17-21
16266695-1	2005	Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime).	Oximes	184-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-163
16266695-1	2005	Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime).	Oximes	184-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	165-169
16266695-2	2005	Two oximes, obidoxime and pralidoxime (2-PAM), are presently commercially available, yet, these compounds are considered to be of insufficient efficacy against certain nerve agents, e.g. soman and cyclosarin.	Oximes	4-10	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	41-44
16266695-7	2005	Reactivation of inhibited AChE is considered to be the main mechanism of action of oximes.	Oximes	83-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-30
16266695-8	2005	Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE.	Oximes	158-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
16266695-8	2005	Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE.	Oximes	158-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-142
16266695-8	2005	Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE.	Oximes	158-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-142
16266695-9	2005	Different theoretical models were used for the evaluation of reactivating efficacy of oximes with nerve agent-inhibited human AChE and for estimating effective oxime concentrations.	Oximes	86-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
16266695-9	2005	Different theoretical models were used for the evaluation of reactivating efficacy of oximes with nerve agent-inhibited human AChE and for estimating effective oxime concentrations.	Oximes	86-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
16293236-1	2005	Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE.	Oximes	359-365	acetylcholinesterase (Cartwright blood group)	Homo sapiens	180-184
16429518-0	2005	Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.	Oximes	30-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-93
16429518-2	2005	The results demonstrate remarkable differences in the reactivation of inhibited brain AChE, depending on the oxime and species	Oximes	109-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90
16429526-0	2005	Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates.	Oximes	30-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
15904945-2	2005	Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness.	Oximes	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
15904945-2	2005	Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness.	Oximes	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
15904945-5	2005	Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes, human erythrocyte AChE can be exploited to test the efficacy of new oximes.	Oximes	92-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
15904945-6	2005	By combining enzyme kinetics (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics a dynamic in vitro model was developed which allows the calculation of AChE activities at different scenarios.	Oximes	90-95	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-188
16214344-0	2006	Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.	Oximes	58-63	O-GlcNAcase	Homo sapiens	14-25
16214344-1	2006	The potent O-GlcNAcase inhibitor PUGNAc was synthesized and two isomers based on the E and Z stereochemistry of the oxime moiety were separated, defined, and tested for activity.	Oximes	116-121	O-GlcNAcase	Homo sapiens	11-22
16601802-0	2005	A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun.	Oximes	73-79	acetylcholinesterase	Rattus norvegicus	110-130
16601802-3	2005	The potency of trimedoxime and other commonly used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate tabun-inhibited acetylcholinesterase and to eliminate tabun-induced acute effects was evaluated using in vitro and in vivo methods.	Oximes	51-57	acetylcholinesterase	Rattus norvegicus	129-149
16601802-3	2005	The potency of trimedoxime and other commonly used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate tabun-inhibited acetylcholinesterase and to eliminate tabun-induced acute effects was evaluated using in vitro and in vivo methods.	Oximes	21-26	acetylcholinesterase	Rattus norvegicus	129-149
16259317-0	2005	A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.	Oximes	35-40	acetylcholinesterase	Rattus norvegicus	150-170
16167316-2	2005	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	84-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
16167316-2	2005	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	84-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
16167316-2	2005	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	84-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
16167316-2	2005	The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy.	Oximes	84-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
16040183-3	2005	Here, oximes as potential reactivators of inhibited AChE may be effective.	Oximes	6-12	acetylcholinesterase	Mus musculus	52-56
16040183-12	2005	The data show different effectiveness of the oximes investigated in reactivation of muscle AChE and recovery of NMT after inhibition by paraoxon.	Oximes	45-51	acetylcholinesterase	Mus musculus	91-95
16040183-13	2005	Although an increase in muscle force by the oximes was accompanied by a measurable increase in AChE activity only in the case of obidoxime, the plot of muscle force against AChE activity as well as lacking evidence for a direct effect and adaptive processes indicate that reactivation of the enzyme is the main mechanism of NMT recovery.	Oximes	44-50	acetylcholinesterase	Mus musculus	95-99
16040183-14	2005	In agreement, in presence of AChE inhibitory concentrations of paraoxon during reactivation a reduced effectiveness of oximes was found.	Oximes	119-125	acetylcholinesterase	Mus musculus	29-33
16170392-6	2005	Oxime K048 seems to be promising reactivator of tabun-inhibited AChE.	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	64-68
16170392-8	2005	The best reactivator of sarin-inhibited AChE seems to be oxime HI-6.	Oximes	57-62	acetylcholinesterase	Rattus norvegicus	40-44
16119192-0	2005	In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.	Oximes	102-108	acetylcholinesterase (Yt blood group)	Sus scrofa	47-67
16119192-1	2005	In vitro as well as in vivo evaluation of the reactivating efficacy of various oximes against nerve agent-inhibited acetylcholinesterase has been usually done with the help of animal experiments.	Oximes	79-85	acetylcholinesterase (Yt blood group)	Sus scrofa	116-136
16119192-3	2005	Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation.	Oximes	54-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
16119193-6	2005	Three newly synthesized oximes achieved similar nucleophilicity at the similar pKa according to 4-PAM, which is very promising for using these derivatives as AChE reactivators.	Oximes	24-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-162
15686348-0	2005	Site-specific polymer attachment to a CCL-5 (RANTES) analogue by oxime exchange.	Oximes	65-70	C-C motif chemokine ligand 5	Homo sapiens	38-43
15686348-0	2005	Site-specific polymer attachment to a CCL-5 (RANTES) analogue by oxime exchange.	Oximes	65-70	C-C motif chemokine ligand 5	Homo sapiens	45-51
15679473-8	2005	Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos.	Oximes	22-27	acetylcholinesterase	Mus musculus	90-110
15989347-3	2005	In the presence of Pd(PPh3)4, the allylic substitution of oximes with allylic carbonate afforded the linear O-allylated oxime ethers selectively without a base.	Oximes	58-64	caveolin 1	Homo sapiens	22-26
15989347-3	2005	In the presence of Pd(PPh3)4, the allylic substitution of oximes with allylic carbonate afforded the linear O-allylated oxime ethers selectively without a base.	Oximes	58-63	caveolin 1	Homo sapiens	22-26
16021679-1	2005	The potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase (AChE) in various parts of pig brain and whole pig brain was evaluated using in vitro methods.	Oximes	30-36	acetylcholinesterase	Sus scrofa	89-93
16021679-3	2005	At concentrations (10(-4) M) corresponding to recommended doses in vivo, the oxime HI-6 seems to be a more efficacious reactivator of sarin-inhibited AChE in whole pig brain as well as in cerebral hemispheres and cerebellum compared with the other oximes studied.	Oximes	77-82	acetylcholinesterase	Sus scrofa	150-154
16025528-3	2005	All oximes are able to reactivate sarin-inhibited AChE.	Oximes	4-10	acetylcholinesterase	Rattus norvegicus	50-54
15901095-1	2005	The potency of newly developed and currently used oximes to reactivate sarin-inhibited acetylcholinesterase was evaluated using in vitro methods.	Oximes	50-56	acetylcholinesterase	Rattus norvegicus	87-107
15901095-4	2005	Although the ability of newly developed oximes to reactivate sarin-inhibited acetylcholinesterase does not reach the reactivating potency of the oxime HI-6, the oxime K033 seems to be a more efficacious reactivator of sarin-inhibited acetylcholinesterase than other currently available oximes (pralidoxime, obidoxime) at concentrations (10(-5)-10(-4)M) corresponding to recommended doses in vivo.	Oximes	40-46	acetylcholinesterase	Rattus norvegicus	77-97
15901095-4	2005	Although the ability of newly developed oximes to reactivate sarin-inhibited acetylcholinesterase does not reach the reactivating potency of the oxime HI-6, the oxime K033 seems to be a more efficacious reactivator of sarin-inhibited acetylcholinesterase than other currently available oximes (pralidoxime, obidoxime) at concentrations (10(-5)-10(-4)M) corresponding to recommended doses in vivo.	Oximes	40-45	acetylcholinesterase	Rattus norvegicus	77-97
15781395-2	2005	The oxime containing penam sulfones strongly inhibited the Escherichia coli TEM-1 and Klebsiella pneumoniae cefotaximase (CTX-1) enzymes, but moderately inhibited the Pseudomonas aeruginosa 46012 cephalosporinase; while the 2beta-substituted-hydrazone derivatives were generally less active against these enzymes.	Oximes	4-9	hypothetical protein	Escherichia coli	76-81
15859286-4	2005	Upon treatment of [ReV(NPh)Cl3(PPh3)2] with L1OH in solution, the neutral azoimine complex [ReV(NPh)Cl3(L1H)], 3, resulted due to the spontaneous transfer of the oxime oxygen atom to a PPh3 ligand, which is eliminated as OPPh3.	Oximes	162-167	protein phosphatase 4 catalytic subunit	Homo sapiens	31-35
15859286-5	2005	In contrast, the oxime of 2-acetylpyridine (L2OH, 4) did not undergo oxygen atom transfer and simply afforded the imine-oxime complex [ReV(NC6H4Y)Cl2(PPh3)(L2O)], 5, upon reacting with [ReV(NC6H4Y)Cl3(PPh3)2] (Y = H, Me, Cl).	Oximes	17-22	protein phosphatase 4 catalytic subunit	Homo sapiens	150-154
15859286-5	2005	In contrast, the oxime of 2-acetylpyridine (L2OH, 4) did not undergo oxygen atom transfer and simply afforded the imine-oxime complex [ReV(NC6H4Y)Cl2(PPh3)(L2O)], 5, upon reacting with [ReV(NC6H4Y)Cl3(PPh3)2] (Y = H, Me, Cl).	Oximes	17-22	protein phosphatase 4 catalytic subunit	Homo sapiens	201-205
15654704-2	2005	Standard treatment involves administration of intravenous atropine and oxime to counter acetylcholinesterase inhibition at the synapse.	Oximes	71-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-108
16259317-1	2005	(1) The efficacy of the oxime HLo7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods.	Oximes	24-29	acetylcholinesterase	Rattus norvegicus	106-126
16259317-1	2005	(1) The efficacy of the oxime HLo7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods.	Oximes	54-60	acetylcholinesterase	Rattus norvegicus	106-126
16259317-4	2005	In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro.	Oximes	31-36	acetylcholinesterase	Rattus norvegicus	116-136
16259317-0	2005	A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.	Oximes	66-72	acetylcholinesterase	Rattus norvegicus	150-170
15532020-0	2004	Synthesis of branched oxime-linked peptide mimetics of the MUC1 containing a universal T-helper epitope.	Oximes	22-27	mucin 1, cell surface associated	Homo sapiens	59-63
15498514-0	2004	Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.	Oximes	123-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67
15498514-3	2004	Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents.	Oximes	14-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
15498514-5	2004	However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences.	Oximes	55-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-97
15498514-5	2004	However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences.	Oximes	55-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-97
15498514-7	2004	The inhibitory potency of OPs, reactivating potency of oximes and spontaneous reactivation and aging were strongly affected by the structural characteristics of the OPs and of the phosphyl-AChE-complex.	Oximes	55-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-193
15498514-9	2004	AChE inhibited by various phosphoramidates was mostly resistant towards reactivation by oximes while phosphonylated AChE was easily reactivated.	Oximes	88-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
15386544-2	2004	In the case of the latter compounds, oximation is accompanied by epimerization at C-5 to avoid the A(1,3)-strain between the oxime OH group and the 5e-aryl ring of the initially formed oxime resulting in 2e,3e,5a,6e-tetraarylpiperidin-4-one oximes.	Oximes	125-130	complement C5	Homo sapiens	82-85
15386544-2	2004	In the case of the latter compounds, oximation is accompanied by epimerization at C-5 to avoid the A(1,3)-strain between the oxime OH group and the 5e-aryl ring of the initially formed oxime resulting in 2e,3e,5a,6e-tetraarylpiperidin-4-one oximes.	Oximes	185-190	complement C5	Homo sapiens	82-85
15386544-2	2004	In the case of the latter compounds, oximation is accompanied by epimerization at C-5 to avoid the A(1,3)-strain between the oxime OH group and the 5e-aryl ring of the initially formed oxime resulting in 2e,3e,5a,6e-tetraarylpiperidin-4-one oximes.	Oximes	241-247	complement C5	Homo sapiens	82-85
15379785-0	2004	Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase.	Oximes	34-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96
15514903-4	2004	Current treatments of patients poisoned with organophosphorus compounds include atropine (in order to protect muscarinic receptors), oximes (in order to accelerate the reactivation of the inhibited acetylcholinesterase) and benzodiazepines (in order to avoid convulsions).	Oximes	133-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	198-218
15544060-2	2004	The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin.	Oximes	8-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-119
15544060-2	2004	The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin.	Oximes	8-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	232-252
15481984-7	2004	The electron density of derivative 28 bound to chicken PARP-1 revealed that the oxime makes a tight hydrogen bond with the catalytic gamma-carboxylate of glutamic acid (Glu) 988 in accordance with our original designs and models.	Oximes	80-85	poly(ADP-ribose) polymerase 1	Gallus gallus	55-61
15379785-1	2004	The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo methods.	Oximes	24-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
15095579-1	2004	The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerve agent sarin [O-isopropylmethylfluorophosphonate] was evaluated.	Oximes	19-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
15173065-3	2004	EXPERIMENTAL DESIGN: (18)F-labeled glucose (Gluc-S-) and cellobiose (Cel-S-) derivatives of aminooxy-functionalized TOCA were synthesized via oxime formation with 4-[(18)F]fluorobenzaldehyde ([(18)F]FBOA-peptides).	Oximes	142-147	glucosidase, beta, acid	Mus musculus	44-48
15068300-0	2004	Synthesis of a new oxime and its application to the construction of a highly selective and sensitive Co(II) PVC-based membrane sensor.	Oximes	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
14985944-1	2004	The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme.	Oximes	82-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-71
14985944-1	2004	The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme.	Oximes	82-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77
15100179-1	2004	Aryl sulfotransferase (AST) IV (also named tyrosine-ester sulfotransferase and ST1A1) is a major phenol sulfotransferase in the rat, and it catalyzes the sulfation of many drugs, carcinogens, and other xenobiotics that contain phenol, benzylic alcohol, N-hydroxy arylamine, and oxime functional groups.	Oximes	278-283	sulfotransferase family 1A member 1	Rattus norvegicus	0-30
15100179-1	2004	Aryl sulfotransferase (AST) IV (also named tyrosine-ester sulfotransferase and ST1A1) is a major phenol sulfotransferase in the rat, and it catalyzes the sulfation of many drugs, carcinogens, and other xenobiotics that contain phenol, benzylic alcohol, N-hydroxy arylamine, and oxime functional groups.	Oximes	278-283	sulfotransferase family 1A member 1	Rattus norvegicus	43-74
15100179-1	2004	Aryl sulfotransferase (AST) IV (also named tyrosine-ester sulfotransferase and ST1A1) is a major phenol sulfotransferase in the rat, and it catalyzes the sulfation of many drugs, carcinogens, and other xenobiotics that contain phenol, benzylic alcohol, N-hydroxy arylamine, and oxime functional groups.	Oximes	278-283	sulfotransferase family 1A member 1	Rattus norvegicus	79-84
15084117-5	2004	Among the pyrazoles synthesized, the oxime (23b) was identified as the most potent COX-2 selective inhibitor.	Oximes	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
14647978-5	2004	Human AChE inhibited by MFPCh, MFP beta Ch or MFPhCh was extremely resistant towards reactivation by oximes.	Oximes	101-107	acetylcholinesterase (Cartwright blood group)	Homo sapiens	6-10
14647978-8	2004	In conclusion, the unexpected results, i.e., high resistance of inhibited AChE towards oxime reactivation and aging, and much lower resistance towards spontaneous reactivation, calls for further experiments at a molecular level for a better understanding of the interactions among AChE, its inhibitors and reactivators.	Oximes	87-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
15171567-0	2004	Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent.	Oximes	0-6	acetylcholinesterase	Rattus norvegicus	41-61
15099445-3	2004	The structure-activity relationship (SAR) study with 12 compounds on tumour necrosis factor (TNF)-alpha inhibition, analysed by the oxime geometry and different size of spacers between the oxime and phenyl group, indicated that there might be at least three possible hydrogen bonding sites in the inhibitor binding pocket of PDE IV.	Oximes	132-137	tumor necrosis factor	Mus musculus	69-103
15099445-3	2004	The structure-activity relationship (SAR) study with 12 compounds on tumour necrosis factor (TNF)-alpha inhibition, analysed by the oxime geometry and different size of spacers between the oxime and phenyl group, indicated that there might be at least three possible hydrogen bonding sites in the inhibitor binding pocket of PDE IV.	Oximes	189-194	tumor necrosis factor	Mus musculus	69-103
15099445-6	2004	In addition, oxime compounds also significantly inhibited both nitric oxide production from activated RAW264.7 cells and T lymphocyte proliferation elicited by concanavalin A but not IL-2.	Oximes	13-18	interleukin 2	Mus musculus	183-187
15023072-1	2004	Selective mutants of mouse acetylcholinesterase (AChE; EC 3.1.1.7) phosphonylated with chiral S(P)- and R(P)-cycloheptyl, -3,3-dimethylbutyl, and -isopropyl methylphosphonyl thiocholines were subjected to reactivation by the oximes HI-6 and 2-PAM and their reactivation kinetics compared with wild-type AChE and butyrylcholinesterase (EC 3.1.1.8).	Oximes	225-231	acetylcholinesterase	Mus musculus	27-47
15023072-1	2004	Selective mutants of mouse acetylcholinesterase (AChE; EC 3.1.1.7) phosphonylated with chiral S(P)- and R(P)-cycloheptyl, -3,3-dimethylbutyl, and -isopropyl methylphosphonyl thiocholines were subjected to reactivation by the oximes HI-6 and 2-PAM and their reactivation kinetics compared with wild-type AChE and butyrylcholinesterase (EC 3.1.1.8).	Oximes	225-231	acetylcholinesterase	Mus musculus	49-53
15034887-3	2004	An iterative method for the synthesis of linear N(OMe) oligosaccharide analogues was demonstrated, based on the use of an unprotected monosaccharide building block in which an oxime functionality at C-6 is converted during the synthesis into the corresponding methoxyamino group.	Oximes	176-181	complement C6	Homo sapiens	199-202
15095579-3	2004	The oxime HS-6 was an effective reactivator of sarin-inhibited AChE.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
15033007-9	2004	The recovery of AChE activity inhibition wasn"t involved in the treatment with memantine on dichlorvos poisoning, therefore, atropine and a proper AChE reactivator (an oxime) should be used clinically.	Oximes	168-173	acetylcholinesterase	Rattus norvegicus	16-20
15033007-9	2004	The recovery of AChE activity inhibition wasn"t involved in the treatment with memantine on dichlorvos poisoning, therefore, atropine and a proper AChE reactivator (an oxime) should be used clinically.	Oximes	168-173	acetylcholinesterase	Rattus norvegicus	147-151
15568733-1	2004	The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-130
15568733-1	2004	The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	132-136
15065394-8	2004	Obidoxime, which is the most widely used reactivator of acetylcholinesterase in the therapy of poisonings by nerve agents at present, is, like in the case of soman poisonings, a relatively least suitable oxime ensuring the survival in lethal tabun poisonings.	Oximes	4-9	acetylcholinesterase	Mus musculus	56-76
12893843-2	2003	Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE).	Oximes	34-40	acetylcholinesterase	Rattus norvegicus	46-66
14529460-3	2003	The main class, including pralidoxime (2-PAM), incorporates conjugated iminium and oxime moieties that are electron affinic.	Oximes	32-37	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	41-44
15446359-4	2004	Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE.	Oximes	0-5	acetylcholinesterase	Rattus norvegicus	75-79
15008517-3	2003	Thus, the oxime K048 seems to be a relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, it could be useful for the treatment of a nerve agent-exposed population if information about detection of the type of nerve agent is not available.	Oximes	10-15	acetylcholinesterase	Rattus norvegicus	73-93
12893843-2	2003	Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE).	Oximes	34-40	acetylcholinesterase	Rattus norvegicus	263-283
12893843-2	2003	Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE).	Oximes	34-40	acetylcholinesterase	Rattus norvegicus	285-289
12915103-13	2003	This persistence may undermine the efficacy of pretreatment with carbamates of percutaneous intoxication in particular due to gradual replacement of carbamate on AChE by (+/-)-VX, whereas classical treatment of intoxication with oximes is hampered by the short persistence of oximes relative to the agent.	Oximes	229-235	acetylcholinesterase	Cavia porcellus	162-166
12970475-0	2003	CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis.	Oximes	75-81	cytochrome P450, family 83, subfamily A, polypeptide 1	Arabidopsis thaliana	0-7
12970475-0	2003	CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis.	Oximes	75-81	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	12-19
12970475-2	2003	Here, we provide biochemical evidence for the functional role of the two cytochromes P450, CYP83A1 and CYP83B1, from Arabidopsis in oxime metabolism in the biosynthesis of glucosinolates.	Oximes	132-137	cytochrome P450, family 83, subfamily A, polypeptide 1	Arabidopsis thaliana	91-98
12970475-2	2003	Here, we provide biochemical evidence for the functional role of the two cytochromes P450, CYP83A1 and CYP83B1, from Arabidopsis in oxime metabolism in the biosynthesis of glucosinolates.	Oximes	132-137	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	103-110
12904068-4	2003	Thus, oxidation of C-6 and introduction in the C-3 position of the potent pharmacophoric group recently introduced by us, in the 17 position of the digitalis skeleton, namely, O-(omega-aminoalkyl)oxime, led to a series of substituted androstanes able to inhibit the Na(+),K(+)-ATPase, most of them with an IC(50) in the low micromolar level, and to induce a positive inotropic effect in guinea pig.	Oximes	195-201	complement C3	Cavia porcellus	47-50
12837382-4	2003	Further, they suggest that the improved performance of dimeric oximes is conferred by two-site binding with one oxime pointing toward the diisopropyl ester at the catalytic site of hAChE and the other anchored at the peripheral site.	Oximes	63-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-186
12837382-4	2003	Further, they suggest that the improved performance of dimeric oximes is conferred by two-site binding with one oxime pointing toward the diisopropyl ester at the catalytic site of hAChE and the other anchored at the peripheral site.	Oximes	63-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-186
12583695-1	2003	Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery.	Oximes	55-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-109
11859013-1	2002	A thorough SAR study of the oxime region of the dual NK(1)/NK(2) antagonist 1 revealed several modifications that result in potent dual antagonists.	Oximes	28-33	sarcosine dehydrogenase	Homo sapiens	11-14
11978898-2	2002	Standard treatment involves the administration of intravenous atropine and an oxime to counter acetylcholinesterase inhibition at the synapse, but the usefulness of oximes is uncertain.	Oximes	78-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-115
15181665-7	2003	In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning.	Oximes	221-227	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
15181665-7	2003	In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning.	Oximes	221-227	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
15181665-17	2003	AChE aging is particularly rapid with dimethyl phosphoryl compounds and may thwart the effective reactivation by oximes, particularly in suicidal poisoning with excessive doses.	Oximes	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
12242610-1	2002	Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime).	Oximes	179-184	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-158
12242610-1	2002	Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime).	Oximes	179-184	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
12242610-5	2002	In order to provide data for a better evaluation of the reactivating potency of oximes, experiments were undertaken to determine the reactivation rate constants of several oximes with human, rabbit, rat and guinea-pig AChE inhibited by the OPs sarin, cyclosarin and VX.	Oximes	80-86	acetylcholinesterase	Cavia porcellus	218-222
12242610-5	2002	In order to provide data for a better evaluation of the reactivating potency of oximes, experiments were undertaken to determine the reactivation rate constants of several oximes with human, rabbit, rat and guinea-pig AChE inhibited by the OPs sarin, cyclosarin and VX.	Oximes	172-178	acetylcholinesterase	Cavia porcellus	218-222
12411190-1	2002	OBJECTIVE: Inhibition of acetylcholinesterase (AChE) in human brain caused by phoxim or phoxim oxon, their reactivation with oxime and aging of phosphorylated AChE were studied and compared in vitro.	Oximes	125-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
11859013-2	2002	Follow up SAR studies on a second-generation scaffold demonstrate that certain polar groups on the oxime can improve the dual binding affinity to the subnanomolar range.	Oximes	99-104	sarcosine dehydrogenase	Homo sapiens	10-13
11856550-2	2002	By reduction of the oxime of 17 beta-hydroxy-androst-4-en-3-one (testosterone), a mixture of the two amino epimers of C-3 were obtained.	Oximes	20-25	complement C3	Homo sapiens	118-121
11562191-0	2001	Toward new designed proteins derived from bovine pancreatic trypsin inhibitor (BPTI): covalent cross-linking of two "core modules" by oxime-forming ligation.	Oximes	134-139	trophoblast Kunitz domain protein 1	Bos taurus	60-77
11749701-1	2001	A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules.	Oximes	8-13	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-82
11749701-1	2001	A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules.	Oximes	8-13	heat shock protein 90 alpha family class A member 1	Homo sapiens	84-89
11708930-3	2001	The OH of the oxime function appears to mimic the phenolic OH present in more "classical" ER ligands because the binding reduced when the oxime OH is methylated (2) or absent (3).	Oximes	14-19	estrogen receptor 1	Homo sapiens	90-92
11708930-3	2001	The OH of the oxime function appears to mimic the phenolic OH present in more "classical" ER ligands because the binding reduced when the oxime OH is methylated (2) or absent (3).	Oximes	138-143	estrogen receptor 1	Homo sapiens	90-92
11700114-0	2001	Synthesis of oxime-linked mucin mimics containing the tumor-related T(N) and sialyl T(N) antigens.	Oximes	13-18	LOC100508689	Homo sapiens	26-31
11700114-1	2001	[reaction--see text] The synthesis of oxime-linked mucin mimics was accomplished via the incorporation of multiple ketone residues into a peptide followed by reaction with aminooxy sugars corresponding to the tumor-related T(N) and sialyl T(N) (ST(N)) antigens.	Oximes	38-43	LOC100508689	Homo sapiens	51-56
11805735-4	2002	The standard treatment consists of reactivation of the inhibited acetylcholinesterase with an oxime antidote and reversal of the biochemical effects of acetylcholine with atropine.	Oximes	94-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	Oximes	28-34	tripartite motif containing 58	Homo sapiens	36-41
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	Oximes	28-34	tripartite motif containing 58	Homo sapiens	131-136
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	Oximes	28-33	tripartite motif containing 58	Homo sapiens	36-41
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	Oximes	28-33	tripartite motif containing 58	Homo sapiens	131-136
11798323-0	2002	Asymmetric methoxyselenenylations and cyclizations with 3-camphorseleno electrophiles containing oxime substituents at C-2.	Oximes	97-102	complement C2	Homo sapiens	119-122
11800598-15	2002	The formation of oxime from DPC 423 (and its analogues) was found to be mediated by rat CYP 3A1/2, which were also responsible for converting the oxime to the GSH trappable reactive intermediate.	Oximes	17-22	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	88-97
11800598-15	2002	The formation of oxime from DPC 423 (and its analogues) was found to be mediated by rat CYP 3A1/2, which were also responsible for converting the oxime to the GSH trappable reactive intermediate.	Oximes	146-151	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	88-97
12475193-2	2002	Included in antidotal medical countermeasures are oximes to reactivate the inhibited cholinesterase.	Oximes	50-56	butyrylcholinesterase	Homo sapiens	85-99
11800023-15	2001	CONCLUSIONS: These results suggest that inhibition of hsp90 function, which causes depletion of hsp90 client proteins in tumor, contributes to the antitumor activity of KF58333, and that the stereochemistry of the oxime moiety is important for the biological activity of radicicol oxime derivatives.	Oximes	214-219	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
11562191-0	2001	Toward new designed proteins derived from bovine pancreatic trypsin inhibitor (BPTI): covalent cross-linking of two "core modules" by oxime-forming ligation.	Oximes	134-139	spleen trypsin inhibitor I	Bos taurus	79-83
11552681-0	2001	Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione.	Oximes	104-110	peroxisome proliferator activated receptor gamma	Homo sapiens	20-68
11393267-1	2001	The temporal profile of butyrylcholinesterase (BuChE) and in vitro pralidoxime-reactivated BuChE was studied in a cohort of 25 organophosphate-poisoned patients to examine their relationship to the development of intermediate syndrome and to understand reasons for lack of efficacy of oxime treatment.	Oximes	73-78	butyrylcholinesterase	Homo sapiens	91-96
11393267-5	2001	Reactivation potentials of BuChE (the difference between oxime-reactivated and -unreactivated enzyme activity) declined significantly with time after organophosphate ingestion.	Oximes	57-62	butyrylcholinesterase	Homo sapiens	27-32
11393267-7	2001	Patients who received oxime prior to hospitalization had a higher rate of intermediate syndrome and lower levels of BuChE at admission than those who had not.	Oximes	22-27	butyrylcholinesterase	Homo sapiens	116-121
11429820-3	2001	Thus, when reacted with oxime methyl ethers of alpha-ketoesters, BrF3 was able to convert the oxime group into a CF2 group and through a new type of rearrangement cause a shift of the carboxylate group to the nitrogen atom.	Oximes	24-29	ATPase H+ transporting accessory protein 1	Homo sapiens	113-116
11429820-3	2001	Thus, when reacted with oxime methyl ethers of alpha-ketoesters, BrF3 was able to convert the oxime group into a CF2 group and through a new type of rearrangement cause a shift of the carboxylate group to the nitrogen atom.	Oximes	94-99	ATPase H+ transporting accessory protein 1	Homo sapiens	113-116
11440563-1	2001	[reaction: see text]anti-Oximes of 2-pyridylacetic acid esters are rapidly transformed to pyridine-2-carbonitrile under a variety of conditions while syn-oximes bearing tert-butyl esters can be conveniently deprotected to the corresponding carboxylic acid with subsequent fragmentation to the nitrile.	Oximes	25-31	synemin	Homo sapiens	150-153
11440563-1	2001	[reaction: see text]anti-Oximes of 2-pyridylacetic acid esters are rapidly transformed to pyridine-2-carbonitrile under a variety of conditions while syn-oximes bearing tert-butyl esters can be conveniently deprotected to the corresponding carboxylic acid with subsequent fragmentation to the nitrile.	Oximes	154-160	synemin	Homo sapiens	150-153
11333274-0	2001	CYP83b1 is the oxime-metabolizing enzyme in the glucosinolate pathway in Arabidopsis.	Oximes	15-20	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	0-7
11333274-1	2001	CYP83B1 from Arabidopsis thaliana has been identified as the oxime-metabolizing enzyme in the biosynthetic pathway of glucosinolates.	Oximes	61-66	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	0-7
11333274-5	2001	By a combined use of bioinformatics, published expression data, and knock-out phenotypes, we identified the cytochrome P450 CYP83B1 as the oxime-metabolizing enzyme in the glucosinolate pathway as evidenced by characterization of the recombinant protein expressed in Escherichia coli.	Oximes	139-144	cytochrome P450, family 83, subfamily B, polypeptide 1	Arabidopsis thaliana	124-131
11552681-1	2001	The molecular modelling of oximes having 5-benzyl-2,4-thiazolidinedione moieties, agonists of the peroxisome proliferator-activated receptor gamma (PPAR gamma), was performed with respect to their structures complexed with the ligand binding domain of PPAR gamma.	Oximes	27-33	peroxisome proliferator activated receptor gamma	Homo sapiens	98-146
11552681-1	2001	The molecular modelling of oximes having 5-benzyl-2,4-thiazolidinedione moieties, agonists of the peroxisome proliferator-activated receptor gamma (PPAR gamma), was performed with respect to their structures complexed with the ligand binding domain of PPAR gamma.	Oximes	27-33	peroxisome proliferator activated receptor gamma	Homo sapiens	148-158
11552681-1	2001	The molecular modelling of oximes having 5-benzyl-2,4-thiazolidinedione moieties, agonists of the peroxisome proliferator-activated receptor gamma (PPAR gamma), was performed with respect to their structures complexed with the ligand binding domain of PPAR gamma.	Oximes	27-33	peroxisome proliferator activated receptor gamma	Homo sapiens	252-262
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Oximes	177-182	tachykinin receptor 2	Homo sapiens	49-52
11123966-3	2000	AST IV is a major cytosolic sulfotransferase in the rat, and it catalyzes the sulfation of various phenols, benzylic alcohols, arylhydroxamic acids, oximes, and primary N-hydroxy arylamines.	Oximes	149-155	sulfotransferase family 1A member 1	Rattus norvegicus	0-6
11123973-3	2000	Electric eel acetylcholinesterase (EEAChE) was inhibited with the four stereoisomers of isomalathion, and rate constants for spontaneous and oxime-mediated reactivation (k(3)) were measured.	Oximes	141-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-33
10979978-0	2000	Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.	Oximes	6-11	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	193-200
10979978-0	2000	Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.	Oximes	6-11	heat shock protein 90 alpha family class A member 1	Homo sapiens	206-211
11204553-6	2000	In contrast a substantial proportion of the erythrocyte acetylcholinesterase is found unaged and therefore sensitive to reactivation by oximes.	Oximes	136-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-76
11204553-7	2000	Samples from an occupational exposure where depressions in plasma or erythrocyte cholinesterase activity from baseline measurements were reactivated ex vivo using the oxime 2-PAM support this hypothesis.	Oximes	167-172	butyrylcholinesterase	Homo sapiens	81-95
11204553-8	2000	These data also confirm that the plasma enzyme is a more sensitive than erythrocyte acetylcholinesterase as an indicator of OP exposure and thus the potential value of ex vivo oxime reactivation of erythrocyte acetylcholinesterase in a blood sample to indicate subclinical OP exposure may be limited.	Oximes	176-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	210-230
10956056-4	2000	Conversion of this product to its bis-oxime derivative with hydroxylamine hydrochloride resulted in two syn- and two anti-oxime isomers that had chromatographic and mass spectral properties identical with the properties of products derived from an authentic standard of 4-oxo-2-nonenal.	Oximes	38-43	synemin	Homo sapiens	104-107
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	C-C motif chemokine ligand 4 like 2	Homo sapiens	160-203
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	C-C motif chemokine ligand 8	Homo sapiens	205-241
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	X-C motif chemokine ligand 1	Homo sapiens	251-263
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	X-C motif chemokine ligand 1	Homo sapiens	265-268
10817663-1	2000	The reactivation of organophosphate-inhibited acetylcholinesterase (AChE) by oximes inevitably results in the formation of highly reactive phosphoryloximes (POX), which are able to re-inhibit the enzyme.	Oximes	77-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Oximes	177-182	tachykinin receptor 1	Homo sapiens	125-128
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Oximes	177-182	tachykinin receptor 2	Homo sapiens	129-132
11055349-2	2000	The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor.	Oximes	33-38	tachykinin receptor 2	Homo sapiens	120-132
10856827-5	2000	Angiotensin II (0.091-0.91 pmol) injected into the AHA produced a pressor response in both WKY and SHR, and the pressor response to angiotensin II was greater in SHR than that of WKY.	Oximes	51-54	angiotensinogen	Rattus norvegicus	0-14
10801325-0	2000	Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.	Oximes	13-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
10801325-2	2000	We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6).	Oximes	131-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
10817663-11	2000	These reactions must be regarded as therapeutically detrimental and disqualify those oximes which are capable of forming stable POX by reactivation of BChE.	Oximes	85-91	butyrylcholinesterase	Homo sapiens	151-155
10817664-3	2000	Human plasma with the butyrylcholinesterase irreversibly blocked by soman was able to stimulate obidoxime-induced reactivation of concentrated erythrocyte acetylcholinesterase (Ery-AChE) to the same extent as was observed with a dilute preparation, suggesting phosphoryl oxime-destroying capacity.	Oximes	100-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
10714503-1	2000	Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated.	Oximes	0-6	peroxisome proliferator activated receptor gamma	Homo sapiens	70-80
10566233-3	1999	Our findings confirm that the new oxime BI-6 is a more effective reactivator of soman-inhibited acetylcholinesterase than obidoxime but not as effective as the oxime HI-6 especially in the peripheral compartment.	Oximes	34-39	acetylcholinesterase	Rattus norvegicus	96-116
10681099-0	2000	Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos.	Oximes	14-19	acetylcholinesterase (Cartwright blood group)	Gallus gallus	74-94
10681099-1	2000	Organophosphorous (OP) insecticide-induced inhibition and oxime reactivation of acetylcholinesterase (AChE) was determined in whole-brain homogenates prepared from 15-d-old chick embryos.	Oximes	58-63	acetylcholinesterase (Cartwright blood group)	Gallus gallus	80-100
10681099-1	2000	Organophosphorous (OP) insecticide-induced inhibition and oxime reactivation of acetylcholinesterase (AChE) was determined in whole-brain homogenates prepared from 15-d-old chick embryos.	Oximes	58-63	acetylcholinesterase (Cartwright blood group)	Gallus gallus	102-106
10681099-3	2000	Following insecticide exposure, an in vitro system compared the capability of the oximes pralidoxime (2-PAM), obidoxime, TMB-4, and HI-6 to reactivate the OP-inhibited AChE.	Oximes	82-88	peptidylglycine alpha-amidating monooxygenase	Gallus gallus	104-107
10681099-3	2000	Following insecticide exposure, an in vitro system compared the capability of the oximes pralidoxime (2-PAM), obidoxime, TMB-4, and HI-6 to reactivate the OP-inhibited AChE.	Oximes	82-88	acetylcholinesterase (Cartwright blood group)	Gallus gallus	168-172
10681099-7	2000	These results suggest that both the OP insecticide inhibiting AChE and the oxime reactivating this enzyme can contribute to the effectiveness of the avian brain AChE reactivation.	Oximes	75-80	acetylcholinesterase (Cartwright blood group)	Gallus gallus	161-165
10717647-9	2000	Protonated oximes of 20-oxosteroids unsubstituted at C-21, C-17 or C-16 produced a characteristic ion at m/z 86 containing the side chain, C-16 and C-17.	Oximes	11-17	TBL1X/Y related 1	Homo sapiens	53-57
10717647-9	2000	Protonated oximes of 20-oxosteroids unsubstituted at C-21, C-17 or C-16 produced a characteristic ion at m/z 86 containing the side chain, C-16 and C-17.	Oximes	11-17	cytokine like 1	Homo sapiens	59-63
10717647-9	2000	Protonated oximes of 20-oxosteroids unsubstituted at C-21, C-17 or C-16 produced a characteristic ion at m/z 86 containing the side chain, C-16 and C-17.	Oximes	11-17	cytokine like 1	Homo sapiens	148-152
10639282-3	1999	Whereas (RS)-4-amino-3-hydroxy-4,5,6,7-tetrahydro-1,2-benzisoxazole (8, exo-THPO) was synthesized via aluminum amalgam reduction of oxime 22a or 22b, compounds 9, 11-13, and 15-17 were obtained via reductive aminations.	Oximes	132-137	5'-3' exoribonuclease 1	Mus musculus	72-75
10639282-3	1999	Whereas (RS)-4-amino-3-hydroxy-4,5,6,7-tetrahydro-1,2-benzisoxazole (8, exo-THPO) was synthesized via aluminum amalgam reduction of oxime 22a or 22b, compounds 9, 11-13, and 15-17 were obtained via reductive aminations.	Oximes	132-137	thrombopoietin	Mus musculus	76-80
10639284-3	1999	This effect was noted in compounds that contained a functionalized oxime moiety or an exomethylene at C-4, and the potencies were typically &lt;10 nM for MMP-3 and &lt;100 nM for MMP-1.	Oximes	67-72	matrix metallopeptidase 3	Homo sapiens	154-159
10639284-3	1999	This effect was noted in compounds that contained a functionalized oxime moiety or an exomethylene at C-4, and the potencies were typically &lt;10 nM for MMP-3 and &lt;100 nM for MMP-1.	Oximes	67-72	matrix metallopeptidase 1	Homo sapiens	179-184
10071778-2	1999	The peptidic oligomers were made by linking several copies of the alpha-MSH fragment analog Nle-Asp-His-[D-Phe]-Arg-Trp-Lys-NH2 to different templates through formation of oxime bonds.	Oximes	172-177	proopiomelanocortin	Homo sapiens	66-75
10433700-0	1999	Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.	Oximes	11-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
10433700-0	1999	Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.	Oximes	59-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
10433700-2	1999	This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4.	Oximes	189-194	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
10433700-2	1999	This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4.	Oximes	253-258	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
10433700-5	1999	However, phosphoryl oximes formed during the reactivation of the diethylphosphoryl-AChE conjugate were not sufficiently stable to be detected by (31)P NMR.	Oximes	20-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
10433700-7	1999	Reactivation of both ethoxy methylphosphonyl- and diethylphosphoryl-AChE by these two oximes was accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase can hydrolyze phosphoryl oxime formed during the reactivation.	Oximes	86-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
10433700-7	1999	Reactivation of both ethoxy methylphosphonyl- and diethylphosphoryl-AChE by these two oximes was accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase can hydrolyze phosphoryl oxime formed during the reactivation.	Oximes	86-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
10433700-8	1999	Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes.	Oximes	35-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
10433700-8	1999	Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes.	Oximes	187-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
10704134-1	1999	Newly synthesized oximes, mono and bis imidazole derivatives, which promise to be more effective acetylcholinesterase reactivators than standard antidotes used, were investigated by spectrophotometric and electrochemical methods.	Oximes	18-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-117
10704134-3	1999	Dissociation constants of those oximes were also obtained by numerical treatment of overlapping equilibria, using the Lavendberg Marquardt least square method, and when compared with the same for some similar compounds, were found to be very effective acetylcholinesterase reactivators.	Oximes	32-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	252-272
10704134-5	1999	The results indicated that many oxime anions will be available at physiological pH 7.4 and a relative increased ability to reactivate inhibited acetylcholinesterase could be expected.	Oximes	32-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	144-164
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	Oximes	60-65	pyridoxal phosphatase	Homo sapiens	71-74
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	Oximes	60-65	cystathionine beta-synthase	Homo sapiens	78-81
10052942-10	1999	The dissociation of PLP is a multistage process involving a short approximately 500 s lag phase, followed by a rapid inactivation and a slower PLP-oxime formation.	Oximes	147-152	pyridoxal phosphatase	Homo sapiens	20-23
10052942-10	1999	The dissociation of PLP is a multistage process involving a short approximately 500 s lag phase, followed by a rapid inactivation and a slower PLP-oxime formation.	Oximes	147-152	pyridoxal phosphatase	Homo sapiens	143-146
10421446-0	1999	Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.	Oximes	97-102	acetylcholinesterase	Mus musculus	58-78
10421479-3	1999	For example, the in vitro stoichiometric neutralization of sarin by AChE was increased from 1:1 to 3200:1 by the addition of the oxime HI-6, while the in vivo stoichiometry was increased to 57:1 in mice by HI-6.	Oximes	129-134	acetylcholinesterase	Mus musculus	68-72
10421479-4	1999	The aging rate of soman-inhibited mouse AChE was reduced 12-fold in a mutant AChE (E202Q) which resulted in a two-fold increase in oxime-assisted detoxification of soman.	Oximes	131-136	acetylcholinesterase	Mus musculus	40-44
10421479-4	1999	The aging rate of soman-inhibited mouse AChE was reduced 12-fold in a mutant AChE (E202Q) which resulted in a two-fold increase in oxime-assisted detoxification of soman.	Oximes	131-136	acetylcholinesterase	Mus musculus	77-81
10421484-1	1999	We previously demonstrated that a combination of cholinesterase (ChE) pre-treatment with an oxime is an effective measure against soman and sarin.	Oximes	92-97	butyrylcholinesterase	Homo sapiens	49-63
10421484-1	1999	We previously demonstrated that a combination of cholinesterase (ChE) pre-treatment with an oxime is an effective measure against soman and sarin.	Oximes	92-97	butyrylcholinesterase	Homo sapiens	65-68
10421484-5	1999	The ChE-sponges retained their catalytic activity under conditions of temperature, time, and drying where the native soluble enzyme would rapidly denature, and can be reused in conjunction with oximes many times.	Oximes	194-200	butyrylcholinesterase	Homo sapiens	4-7
10421484-6	1999	The ChE-sponge in the presence of oxime repeatedly detoxified OPs such as DFP or MEPQ.	Oximes	34-39	butyrylcholinesterase	Homo sapiens	4-7
10207609-2	1999	Since the oxime effectiveness is influenced not only by its reactivating potential but also by inhibition, aging and spontaneous reactivation kinetics, experiments were performed with human acetyl- (AChE) and butyrylcholinesterase (BChE) to determine the respective kinetic constants.	Oximes	10-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-203
10207609-2	1999	Since the oxime effectiveness is influenced not only by its reactivating potential but also by inhibition, aging and spontaneous reactivation kinetics, experiments were performed with human acetyl- (AChE) and butyrylcholinesterase (BChE) to determine the respective kinetic constants.	Oximes	10-15	butyrylcholinesterase	Homo sapiens	209-230
10207609-2	1999	Since the oxime effectiveness is influenced not only by its reactivating potential but also by inhibition, aging and spontaneous reactivation kinetics, experiments were performed with human acetyl- (AChE) and butyrylcholinesterase (BChE) to determine the respective kinetic constants.	Oximes	10-15	butyrylcholinesterase	Homo sapiens	232-236
10207609-7	1999	These data indicate that oximes may effectively reactivate human dimethylphosphoryl-AChE.	Oximes	25-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
10207609-9	1999	The potency of the oximes to reactivate dimethylphosphoryl-BChE was much lower and the spontaneous reactivation slower (t1/2 9 h), while aging proceeded at a comparable rate.	Oximes	19-25	butyrylcholinesterase	Homo sapiens	59-63
9171871-0	1997	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5"-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.	Oximes	117-123	adenosylhomocysteinase	Homo sapiens	53-88
9772214-2	1998	The protective effect of the oxime 2-PAM against inhibition of acetylcholinesterase (AChE) by paraoxon was estimated in vitro and in vivo and was correlated with the mortality of paraoxon-treated bees.	Oximes	29-34	acetylcholinesterase	Apis mellifera	63-83
9772214-2	1998	The protective effect of the oxime 2-PAM against inhibition of acetylcholinesterase (AChE) by paraoxon was estimated in vitro and in vivo and was correlated with the mortality of paraoxon-treated bees.	Oximes	29-34	acetylcholinesterase	Apis mellifera	85-89
9448738-0	1998	Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates.	Oximes	50-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-122
9507700-1	1998	The synthesis and biological evaluation of oximes of 2-aryl-6-methoxy-3,4-dihydronaphthalene (7a, 7b, 14a, 14b) as nonsteroidal inhibitors of 17 alpha-hydroxylase-C17,20-lyase (P450 17, CYP 17) is described.	Oximes	43-49	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	186-192
9359435-6	1997	Wild-type BuChE and mutants were inhibited by di-isopropylfluorophosphate at pH 8.0 and 25 degrees C. Di-isopropyl-phosphorylated enzymes were incubated with the nucleophilic oxime 2-pyridine aldoxime methiodide and their reactivatability was determined.	Oximes	175-180	butyrylcholinesterase	Homo sapiens	10-15
9806430-8	1998	By contrast, HLo 7 was shown to be an extremely potent reactivator of human AChE and BChE, which supports its position as a broad-spectrum oxime.	Oximes	139-144	butyrylcholinesterase	Homo sapiens	85-89
9547363-1	1998	Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning.	Oximes	78-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
9547363-4	1998	To better understand the acceleration phenomenon, we examined ligand modulations of oxime-induced reactivation of methylphosphonylated AChE using 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide and fetal bovine serum AChE.	Oximes	84-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
9547363-4	1998	To better understand the acceleration phenomenon, we examined ligand modulations of oxime-induced reactivation of methylphosphonylated AChE using 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide and fetal bovine serum AChE.	Oximes	84-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	226-230
9547363-9	1998	Propidium slowed the reactivation of 7-(methylethoxyphosphinyloxy)-1- methylquinolinium iodide-inhibited AChE by all oximes.	Oximes	117-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
9635412-5	1998	Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE.	Oximes	27-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
9635412-5	1998	Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE.	Oximes	129-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-172
9635412-5	1998	Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE.	Oximes	129-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
9587020-4	1998	Since oximes are believed to act primarily through reactivation of inhibited acetylcholinesterase (AChE) and erythrocyte AChE is regarded to be a good marker for the synaptic enzyme, the reactivating potency can be investigated with human erythrocyte AChE in vitro.	Oximes	6-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
9587020-4	1998	Since oximes are believed to act primarily through reactivation of inhibited acetylcholinesterase (AChE) and erythrocyte AChE is regarded to be a good marker for the synaptic enzyme, the reactivating potency can be investigated with human erythrocyte AChE in vitro.	Oximes	6-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
9587020-5	1998	The present study was undertaken to evaluate the ability of various oximes at concentrations therapeutically relevant in humans to reactivate human erythrocyte AChE inhibited by different nerve agents.	Oximes	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
9587020-8	1998	The reactivation of human AChE by oximes was dependent on the organophosphate used.	Oximes	34-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-30
9543466-5	1998	Acetylcholinesterase inhibition produced by metrifonate occurs rapidly, is dose dependent, can be detected by inhibition measured in red blood cells, and can be reversed by oxime administration.	Oximes	173-178	acetylcholinesterase	Rattus norvegicus	0-20
9600150-3	1998	The subsequent antidotal therapy resulted in variously high reactivation of cyclosin-inhibited acetylcholinesterase in dependence on the selection of oxime.	Oximes	150-155	acetylcholinesterase	Rattus norvegicus	95-115
9292287-6	1997	Obidoxime turned out to be the most potent and most efficacious oxime in reactivating AChE inhibited by various classes of OP insecticides and tabun.	Oximes	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90
9292287-10	1997	However, in suicidal mega-dose poisoning, oximes, even at optimal plasma concentrations, may be unable to cope with the fast re-inhibition of reactivated AChE in the first days following intoxication.	Oximes	42-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	154-158
9292288-3	1997	By virtue of in vitro findings and theoretical considerations we concluded in the preceding paper that oximes should preferably be administered by continuous infusion following an initial bolus dose for as long as reactivation of inhibited acetylcholinesterase (AChE) can be expected.	Oximes	103-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	240-260
9292288-3	1997	By virtue of in vitro findings and theoretical considerations we concluded in the preceding paper that oximes should preferably be administered by continuous infusion following an initial bolus dose for as long as reactivation of inhibited acetylcholinesterase (AChE) can be expected.	Oximes	103-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	262-266
9271331-3	1997	Aging has proven to be a major barrier to achieving oxime reactivation of acetylcholinesterase (AChE) inhibited by the more potent OPs.	Oximes	52-57	acetylcholinesterase	Mus musculus	74-94
9271331-3	1997	Aging has proven to be a major barrier to achieving oxime reactivation of acetylcholinesterase (AChE) inhibited by the more potent OPs.	Oximes	52-57	acetylcholinesterase	Mus musculus	96-100
9209694-1	1997	The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice.	Oximes	36-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-132
9209694-1	1997	The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice.	Oximes	36-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
8619258-0	1996	Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates.	Oximes	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
8691435-3	1996	Among these naphthoic acids, oxime derivative 12 was identified as a potent RAR gamma-selective retinoid, while olefinic derivative 11 was found to be comparable to retinoic acid and slightly RAR beta,gamma selective.	Oximes	29-34	retinoic acid receptor gamma	Homo sapiens	76-85
8902275-4	1996	Studies on the biochemical mechanism of oxime formation suggested that cis-oxime formation in the presence of adult human liver microsomes was largely dependent on the human flavin-containing monooxygenase (form 3).	Oximes	40-45	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	174-213
8794905-0	1996	Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.	Oximes	16-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
8911635-2	1996	Although oximes have been designed to reactivate the inhibited acetylcholinesterase (AChE), clinical experience has indicated that they are not always very effective as reactivators and at this very moment none of them can be regarded as a broad-spectrum antidote.	Oximes	9-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-83
8783813-0	1996	Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds.	Oximes	24-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-72
8783813-5	1996	The oximes significantly, but not completely, reactivated organophosphate inhibited AChE.	Oximes	4-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
8911635-2	1996	Although oximes have been designed to reactivate the inhibited acetylcholinesterase (AChE), clinical experience has indicated that they are not always very effective as reactivators and at this very moment none of them can be regarded as a broad-spectrum antidote.	Oximes	9-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
8603667-1	1996	The oxime HI-6 dichloride [1-(2 hydroxyiminomethyl -1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate] has shown to be a potent reactivator of cholinesterase activity and may have efficacy for the treatment of organophosphate intoxication [SIPRI, 1976; Schenk et al.	Oximes	4-9	butyrylcholinesterase	Rattus norvegicus	168-182
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	39-44
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-62
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	39-44
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-62
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8582034-8	1996	The in vitro inhibitory effect of oxime-2 and oxime-3 on COX-1 activity decreased with O-acylation of the oximes.	Oximes	34-39	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-62
8582034-8	1996	The in vitro inhibitory effect of oxime-2 and oxime-3 on COX-1 activity decreased with O-acylation of the oximes.	Oximes	46-51	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-62
8582034-8	1996	The in vitro inhibitory effect of oxime-2 and oxime-3 on COX-1 activity decreased with O-acylation of the oximes.	Oximes	106-112	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-62