PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17957723-3	2008	DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.	dim-c-pphoch(3)	0-15	BCL2 associated X, apoptosis regulator	Homo sapiens	177-180
20023005-5	2010	DIM-C-pPhOCH(3) (25 mg/kg/d) also induced apoptosis and inhibited tumor growth in athymic nude mice bearing KU7 cells as xenografts, demonstrating that Nur77-active C-DIMs exhibit potential for bladder cancer chemotherapy by targeting Nur77, which is overexpressed in this tumor type.	dim-c-pphoch(3)	0-15	nuclear receptor subfamily 4 group A member 1	Homo sapiens	152-157
20023005-5	2010	DIM-C-pPhOCH(3) (25 mg/kg/d) also induced apoptosis and inhibited tumor growth in athymic nude mice bearing KU7 cells as xenografts, demonstrating that Nur77-active C-DIMs exhibit potential for bladder cancer chemotherapy by targeting Nur77, which is overexpressed in this tumor type.	dim-c-pphoch(3)	0-15	nuclear receptor subfamily 4 group A member 1	Homo sapiens	235-240
17957723-3	2008	DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.	dim-c-pphoch(3)	0-15	BCL2 apoptosis regulator	Homo sapiens	181-186
17957723-3	2008	DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.	dim-c-pphoch(3)	0-15	cytochrome c, somatic	Homo sapiens	209-221
17957723-4	2008	DIM-C-pPhOCH(3) also induced phosphatidylinositol-3-kinase-dependent activation of early growth response gene-1 which, in turn, induced expression of the proapoptotic nonsteroidal anti-inflammatory drug-activated gene-1 (NAG1) in RKO and SW480 colon cancer cells.	dim-c-pphoch(3)	0-15	growth differentiation factor 15	Homo sapiens	167-219
17957723-4	2008	DIM-C-pPhOCH(3) also induced phosphatidylinositol-3-kinase-dependent activation of early growth response gene-1 which, in turn, induced expression of the proapoptotic nonsteroidal anti-inflammatory drug-activated gene-1 (NAG1) in RKO and SW480 colon cancer cells.	dim-c-pphoch(3)	0-15	growth differentiation factor 15	Homo sapiens	221-225
17957723-5	2008	Moreover, DIM-C-pPhOCH(3) also induced NAG-1 expression in colon tumors in athymic nude mice bearing RKO cells as xenografts.	dim-c-pphoch(3)	10-25	growth differentiation factor 15	Mus musculus	39-44
17957723-6	2008	DIM-C-pPhOCH(3) also activated the extrinsic apoptosis pathway through increased phosphorylation of c-jun N-terminal kinase which, in turn, activated C/EBP homologous transcription factor (CHOP) and death receptor 5 (DR5).	dim-c-pphoch(3)	0-15	DNA damage inducible transcript 3	Homo sapiens	150-187
17957723-6	2008	DIM-C-pPhOCH(3) also activated the extrinsic apoptosis pathway through increased phosphorylation of c-jun N-terminal kinase which, in turn, activated C/EBP homologous transcription factor (CHOP) and death receptor 5 (DR5).	dim-c-pphoch(3)	0-15	DNA damage inducible transcript 3	Homo sapiens	189-193
17957723-6	2008	DIM-C-pPhOCH(3) also activated the extrinsic apoptosis pathway through increased phosphorylation of c-jun N-terminal kinase which, in turn, activated C/EBP homologous transcription factor (CHOP) and death receptor 5 (DR5).	dim-c-pphoch(3)	0-15	TNF receptor superfamily member 10b	Homo sapiens	199-215
17957723-6	2008	DIM-C-pPhOCH(3) also activated the extrinsic apoptosis pathway through increased phosphorylation of c-jun N-terminal kinase which, in turn, activated C/EBP homologous transcription factor (CHOP) and death receptor 5 (DR5).	dim-c-pphoch(3)	0-15	TNF receptor superfamily member 10b	Homo sapiens	217-220