PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3946101-1	1986	A radioimmunoassay for 5 alpha-pregnane-3,20-dione (5 alpha-DHP) in plasma is described.	5-alpha-Dihydroprogesterone	23-50	dihydropyrimidinase	Homo sapiens	60-63
2591716-5	1989	Furthermore, the androgen production was diminished, and the production of 5 beta-reduced C21 metabolites such as 5 beta-pregnane-3,20-dione and 3 alpha-hydroxy-5 beta-pregnan-20-one was also reduced in the hCG-treated group.	5-alpha-Dihydroprogesterone	114-140	chorionic gonadotropin subunit beta 5	Homo sapiens	207-210
2755131-9	1989	These findings are consistent with the identification of peak 1a as 5 alpha-dihydroprogesterone, peak 1b as progesterone and peak 3 as 2-methoxyestrone as described in part 2.	5-alpha-Dihydroprogesterone	68-95	pseudopodium enriched atypical kinase 1	Homo sapiens	57-63
3564086-1	1986	The specific binding of 5 alpha-dihydroprogesterone (5 alpha-DHP), progesterone and R5020 to anterior pituitary nuclear extracts was studied using ovariectomized rats treated with estradiol benzoate and progesterone.	5-alpha-Dihydroprogesterone	24-51	dihydropyrimidinase	Rattus norvegicus	61-64
849732-6	1977	Addition of 200 IU of human chorionic gonadotropin (hCG) in vitro to normal basal zone placentae sharply increased the production of progesterone, 17alpha-hydroxyprogesterone, androstenedione and 5alpha-pregnane-3,20-dione.	5-alpha-Dihydroprogesterone	196-222	hypertrichosis 2 (generalised, congenital)	Homo sapiens	52-55
6541733-5	1984	The reduction of 5 alpha-pregnane-3,20-dione at C-3 followed by a 6 alpha-hydroxylation can be postulated as the major, if not the only, metabolic pathway.	5-alpha-Dihydroprogesterone	17-44	complement C3	Rattus norvegicus	48-51
744056-0	1978	In vivo uterine metabolism of progesterone and 5 alpha-pregnane-3,20-dione during the synthesis and release of uteroglobin in ovariectomized, steroid-treated rabbits.	5-alpha-Dihydroprogesterone	47-74	uteroglobin	Oryctolagus cuniculus	111-122
6660916-2	1983	A radioimmunoassay (RIA) procedure has been developed for the measurement of 5 alpha-pregnane-3,20-dione (DHP) in human plasma after ether extraction of the plasma-samples, followed by column chromatography.	5-alpha-Dihydroprogesterone	77-104	dihydropyrimidinase	Homo sapiens	106-109
96697-0	1978	Modification of vascular responsiveness to angiotensin II in pregnant women by intravenously infused 5alpha-dihydroprogesterone.	5-alpha-Dihydroprogesterone	101-127	angiotensinogen	Homo sapiens	43-57
96697-4	1978	In seven women who had developed PIH and who had lost their refractoriness to A-II, the infusion of 5alpha-pregnan-3,20-dione (5alpha-DHP) was associated with restoration of refractoriness to the pressor effects of A-II.	5-alpha-Dihydroprogesterone	127-137	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	33-36
96697-4	1978	In seven women who had developed PIH and who had lost their refractoriness to A-II, the infusion of 5alpha-pregnan-3,20-dione (5alpha-DHP) was associated with restoration of refractoriness to the pressor effects of A-II.	5-alpha-Dihydroprogesterone	127-137	angiotensinogen	Homo sapiens	78-82
96697-4	1978	In seven women who had developed PIH and who had lost their refractoriness to A-II, the infusion of 5alpha-pregnan-3,20-dione (5alpha-DHP) was associated with restoration of refractoriness to the pressor effects of A-II.	5-alpha-Dihydroprogesterone	127-137	angiotensinogen	Homo sapiens	215-219
11093-0	1976	Interaction of uteroglobin with progesterone, 5alphapregnane-3,20-dione and estrogens.	5-alpha-Dihydroprogesterone	46-71	uteroglobin	Oryctolagus cuniculus	15-26
11093-7	1976	Uteroglobin had a relatively high affinity for progesterone (KD=4.1 X 10(-7)M) but a threefold higher affinity for 5alpha-pregnane-3,20-dione (KD=1.3 X 10(-7)M).	5-alpha-Dihydroprogesterone	115-141	uteroglobin	Oryctolagus cuniculus	0-11
27045679-1	2016	An investigation of aspects ranging from behavior to molecular electronic structure and physicochemical properties was performed to explore the role of 5alpha-pregnanedione (5alpha-DHP), 5beta-pregnanedione (5beta-DHP) and their precursor progesterone (P) on the concurrent inhibition of the sexual lordosis response in female rats.	5-alpha-Dihydroprogesterone	152-172	dihydropyrimidinase	Rattus norvegicus	181-184
31252409-4	2019	Progesterone declines as the endometrial cups and eCG disappears, replaced by 5alpha-dihydroprogesterone (DHP), a potent equine progesterone receptor (PR) agonist, as the chorioallantoic placenta develops.	5-alpha-Dihydroprogesterone	78-104	progesterone receptor	Equus caballus	128-149
31252409-4	2019	Progesterone declines as the endometrial cups and eCG disappears, replaced by 5alpha-dihydroprogesterone (DHP), a potent equine progesterone receptor (PR) agonist, as the chorioallantoic placenta develops.	5-alpha-Dihydroprogesterone	78-104	progesterone receptor	Equus caballus	151-153
31252409-4	2019	Progesterone declines as the endometrial cups and eCG disappears, replaced by 5alpha-dihydroprogesterone (DHP), a potent equine progesterone receptor (PR) agonist, as the chorioallantoic placenta develops.	5-alpha-Dihydroprogesterone	106-109	progesterone receptor	Equus caballus	128-149
31252409-4	2019	Progesterone declines as the endometrial cups and eCG disappears, replaced by 5alpha-dihydroprogesterone (DHP), a potent equine progesterone receptor (PR) agonist, as the chorioallantoic placenta develops.	5-alpha-Dihydroprogesterone	106-109	progesterone receptor	Equus caballus	151-153
31107530-4	2019	In the current study, SRD5A1 and AKR1C23, which encode for the key P4 metabolizing enzymes, were downregulated in P1 in comparison to C1, C2, and P2, and this was associated with a decline (P < 0.05) in 5alphaDHP, allopregnanolone (3alphaDHP), and 20alphaDHP in P1 in comparison to C1.	5-alpha-Dihydroprogesterone	206-215	steroid 5 alpha-reductase 1	Equus caballus	22-28
31107530-4	2019	In the current study, SRD5A1 and AKR1C23, which encode for the key P4 metabolizing enzymes, were downregulated in P1 in comparison to C1, C2, and P2, and this was associated with a decline (P < 0.05) in 5alphaDHP, allopregnanolone (3alphaDHP), and 20alphaDHP in P1 in comparison to C1.	5-alpha-Dihydroprogesterone	206-215	aldo-keto reductase family 1 member C23	Equus caballus	33-40
1276309-0	1976	The plasma level of 5alpha-DHP after intramuscular injection of 5alpha-DHP and the induction of uteroglobin in ovariectomized rabbits.	5-alpha-Dihydroprogesterone	20-30	uteroglobin	Oryctolagus cuniculus	96-107
32730775-7	2020	The treatment with the progesterone receptor (PR) antagonist RU486 (mifepristone), blocked the effects of 5alpha-DHP on the number of cells and proliferation.	5-alpha-Dihydroprogesterone	106-116	progesterone receptor	Homo sapiens	23-44
32730775-7	2020	The treatment with the progesterone receptor (PR) antagonist RU486 (mifepristone), blocked the effects of 5alpha-DHP on the number of cells and proliferation.	5-alpha-Dihydroprogesterone	106-116	progesterone receptor	Homo sapiens	46-48
32730775-10	2020	These data indicate that 5alpha-DHP induces proliferation and migration of human GBM through the activation of PR.	5-alpha-Dihydroprogesterone	25-35	progesterone receptor	Homo sapiens	111-113
31990666-6	2020	Both SRD5A1 and AKR1C23, which encode for the key progesterone metabolizing enzymes, were downregulated (P<0.05) in CA from the placentitis group compared to controls, and this downregulation was associated with a decline in tissue concentrations of 5alphaDHP (P<0.05), 3alphaDHP (P<0.05), and 3beta-20alphaDHP (P=0.052).	5-alpha-Dihydroprogesterone	253-262	steroid 5 alpha-reductase 1	Equus caballus	5-11
31990666-6	2020	Both SRD5A1 and AKR1C23, which encode for the key progesterone metabolizing enzymes, were downregulated (P<0.05) in CA from the placentitis group compared to controls, and this downregulation was associated with a decline in tissue concentrations of 5alphaDHP (P<0.05), 3alphaDHP (P<0.05), and 3beta-20alphaDHP (P=0.052).	5-alpha-Dihydroprogesterone	253-262	aldo-keto reductase family 1 member C23	Equus caballus	16-23
31990666-6	2020	Both SRD5A1 and AKR1C23, which encode for the key progesterone metabolizing enzymes, were downregulated (P<0.05) in CA from the placentitis group compared to controls, and this downregulation was associated with a decline in tissue concentrations of 5alphaDHP (P<0.05), 3alphaDHP (P<0.05), and 3beta-20alphaDHP (P=0.052).	5-alpha-Dihydroprogesterone	276-285	steroid 5 alpha-reductase 1	Equus caballus	5-11
31990666-6	2020	Both SRD5A1 and AKR1C23, which encode for the key progesterone metabolizing enzymes, were downregulated (P<0.05) in CA from the placentitis group compared to controls, and this downregulation was associated with a decline in tissue concentrations of 5alphaDHP (P<0.05), 3alphaDHP (P<0.05), and 3beta-20alphaDHP (P=0.052).	5-alpha-Dihydroprogesterone	276-285	aldo-keto reductase family 1 member C23	Equus caballus	16-23
25161074-2	2014	One report showed fluoxetine to activate the aldo-keto reductase (AKR) component of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), which catalyses production of allopregnanolone from 5alpha-dihydroprogesterone.	5-alpha-Dihydroprogesterone	186-212	aldo-keto reductase family 1, member C14	Rattus norvegicus	84-119
26519986-0	2016	Mechanism of action of the breast cancer-promoter hormone, 5alpha-dihydroprogesterone (5alphaP), involves plasma membrane-associated receptors and MAPK activation.	5-alpha-Dihydroprogesterone	59-85	mitogen-activated protein kinase 3	Homo sapiens	147-151
26519986-0	2016	Mechanism of action of the breast cancer-promoter hormone, 5alpha-dihydroprogesterone (5alphaP), involves plasma membrane-associated receptors and MAPK activation.	5-alpha-Dihydroprogesterone	87-94	mitogen-activated protein kinase 3	Homo sapiens	147-151
25556800-12	2015	This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively.	5-alpha-Dihydroprogesterone	145-171	demilune cell and parotid protein 1	Mus musculus	101-104
25556800-12	2015	This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively.	5-alpha-Dihydroprogesterone	145-171	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	118-123
25556800-12	2015	This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively.	5-alpha-Dihydroprogesterone	145-171	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	304-309
25556800-12	2015	This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively.	5-alpha-Dihydroprogesterone	173-183	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	118-123
25556800-12	2015	This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively.	5-alpha-Dihydroprogesterone	173-183	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	304-309
26626485-4	2016	Treatment of cortical slices with the immediate precursor of 5alpha-pregnan-3alpha-ol-20-one (5alpha3alpha), the GABAAR-inactive 5alpha-dihydroprogesterone, (5alpha-DHP), greatly prolonged the mIPSCs of P20 pyramidal neurons, demonstrating these more mature neurons retain the capacity to synthesize GABAAR-active neurosteroids, but now lack the endogenous steroid substrate.	5-alpha-Dihydroprogesterone	158-168	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	113-119
25161074-2	2014	One report showed fluoxetine to activate the aldo-keto reductase (AKR) component of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), which catalyses production of allopregnanolone from 5alpha-dihydroprogesterone.	5-alpha-Dihydroprogesterone	186-212	aldo-keto reductase family 1, member C14	Rattus norvegicus	121-131
25161074-6	2014	Subcellular fractions of rat brain were also used to investigate the actions of fluoxetine on 3alpha-HSD activity in both the reductive direction, producing allopregnanolone from 5alpha-dihydroprogesterone, and the reverse oxidative direction.	5-alpha-Dihydroprogesterone	179-205	aldo-keto reductase family 1, member C14	Rattus norvegicus	94-104
23781171-8	2013	In addition, ALLO is metabolized to another compound, 5alpha-dihydroprogesterone, which binds Pgr, suggesting ALLO actions may involve signaling through Pgr as well as the aforementioned mechanisms of action.	5-alpha-Dihydroprogesterone	54-80	progesterone receptor	Homo sapiens	94-97
24550466-0	2014	Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5alpha-dihydroprogesterone.	5-alpha-Dihydroprogesterone	110-136	progesterone receptor	Equus caballus	79-100
23781171-8	2013	In addition, ALLO is metabolized to another compound, 5alpha-dihydroprogesterone, which binds Pgr, suggesting ALLO actions may involve signaling through Pgr as well as the aforementioned mechanisms of action.	5-alpha-Dihydroprogesterone	54-80	progesterone receptor	Homo sapiens	153-156
22291648-3	2011	Placental AKR1D1 (human 5beta reductase) likely contributes to the maintenance of pregnancy through the formation of 5beta-dihydroprogesterone (DHP).	5-alpha-Dihydroprogesterone	117-142	aldo-keto reductase family 1 member D1	Homo sapiens	10-16
22291648-3	2011	Placental AKR1D1 (human 5beta reductase) likely contributes to the maintenance of pregnancy through the formation of 5beta-dihydroprogesterone (DHP).	5-alpha-Dihydroprogesterone	144-147	aldo-keto reductase family 1 member D1	Homo sapiens	10-16
15951421-3	2005	Here, we show that in the spinal sensory circuit progesterone conversion into 5alpha-DHP and 3alpha,5alpha-THP is inhibited dose-dependently by substance P (SP), a major mediator of painful signals.	5-alpha-Dihydroprogesterone	78-88	tachykinin precursor 1	Homo sapiens	144-155
17159084-11	2007	Treatment of PXR(+/+) and PXR(-/-) nonpregnant mice with 5beta-dihydroprogesterone for 7 days enhanced endothelium-dependent relaxation in only the PXR(+/+) mice, similarly to that seen in pregnancy.	5-alpha-Dihydroprogesterone	57-82	nuclear receptor subfamily 1, group I, member 2	Mus musculus	13-16
17159084-11	2007	Treatment of PXR(+/+) and PXR(-/-) nonpregnant mice with 5beta-dihydroprogesterone for 7 days enhanced endothelium-dependent relaxation in only the PXR(+/+) mice, similarly to that seen in pregnancy.	5-alpha-Dihydroprogesterone	57-82	nuclear receptor subfamily 1, group I, member 2	Mus musculus	26-29
17159084-11	2007	Treatment of PXR(+/+) and PXR(-/-) nonpregnant mice with 5beta-dihydroprogesterone for 7 days enhanced endothelium-dependent relaxation in only the PXR(+/+) mice, similarly to that seen in pregnancy.	5-alpha-Dihydroprogesterone	57-82	nuclear receptor subfamily 1, group I, member 2	Mus musculus	26-29
16611167-4	2006	This enzyme inactivates 17beta-estradiol and exhibits a strong oxidative 3alpha-HSD activity to convert 5alpha-androstanediol and allopregnanolone into 5alpha-dihydrotestosterone (5alpha-DHT) and 5alpha-dihydroprogesterone, respectively, in living cells.	5-alpha-Dihydroprogesterone	196-222	aldo-keto reductase family 1 member C4	Homo sapiens	73-83
16344854-7	2006	In vitro investigations demonstrated a dose-dependent inhibitory effect of mirtazapine on the activity of the microsomal 3alpha-HSD in the oxidative direction (conversion of 3alpha,5alpha-tetrahydroprogesterone to 5alpha-dihydroprogesterone).	5-alpha-Dihydroprogesterone	214-240	aldo-keto reductase family 1 member C3	Homo sapiens	121-131
19931389-0	2010	Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.	5-alpha-Dihydroprogesterone	50-76	BCL2 apoptosis regulator	Homo sapiens	170-175
17084970-3	2007	In 2003, we reported that progesterone"s first metabolite, 5alpha-dihydroprogesterone (5alpha-DHP), has strong anticonvulsant effects in amygdala-kindled female rats.	5-alpha-Dihydroprogesterone	59-85	dihydropyrimidinase	Rattus norvegicus	94-97
15951421-5	2005	Evidence for a potent inhibitory effect of SP on 5alpha-DHP and 3alpha,5alpha-THP formation in the SC was provided by combining pulse-chase experiments using [3H]progesterone as precursor, HPLC, recrystallization of [3H]metabolites to constant specific activity, and continuous flow detection of radioactive steroids.	5-alpha-Dihydroprogesterone	49-59	tachykinin precursor 1	Homo sapiens	43-45
15951421-7	2005	The selective rNK1 antagonist SR140333 totally reversed the effect of SP on progesterone conversion into 5alpha-DHP and 3alpha,5alpha-THP.	5-alpha-Dihydroprogesterone	105-115	nicotinamide riboside kinase 1	Rattus norvegicus	14-18
15951421-7	2005	The selective rNK1 antagonist SR140333 totally reversed the effect of SP on progesterone conversion into 5alpha-DHP and 3alpha,5alpha-THP.	5-alpha-Dihydroprogesterone	105-115	tachykinin precursor 1	Homo sapiens	70-72
15951421-3	2005	Here, we show that in the spinal sensory circuit progesterone conversion into 5alpha-DHP and 3alpha,5alpha-THP is inhibited dose-dependently by substance P (SP), a major mediator of painful signals.	5-alpha-Dihydroprogesterone	78-88	tachykinin precursor 1	Homo sapiens	157-159
15846226-1	2005	OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility.	5-alpha-Dihydroprogesterone	66-91	nuclear receptor subfamily 1, group I, member 2	Mus musculus	141-160
15846226-1	2005	OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility.	5-alpha-Dihydroprogesterone	66-91	nuclear receptor subfamily 1, group I, member 2	Mus musculus	162-165
15846226-1	2005	OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility.	5-alpha-Dihydroprogesterone	93-102	nuclear receptor subfamily 1, group I, member 2	Mus musculus	141-160
15846226-1	2005	OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility.	5-alpha-Dihydroprogesterone	93-102	nuclear receptor subfamily 1, group I, member 2	Mus musculus	162-165
15846226-6	2005	Chronic in vivo administration of 5beta-DHP to mice with intact PXR, but not in mice with disrupted PXR, causes an increased effect of 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS).	5-alpha-Dihydroprogesterone	34-43	nuclear receptor subfamily 1, group I, member 2	Mus musculus	64-67
15846226-6	2005	Chronic in vivo administration of 5beta-DHP to mice with intact PXR, but not in mice with disrupted PXR, causes an increased effect of 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS).	5-alpha-Dihydroprogesterone	34-43	nitric oxide synthase 2, inducible	Mus musculus	166-197
15846226-6	2005	Chronic in vivo administration of 5beta-DHP to mice with intact PXR, but not in mice with disrupted PXR, causes an increased effect of 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS).	5-alpha-Dihydroprogesterone	34-43	nitric oxide synthase 2, inducible	Mus musculus	199-203
15846226-7	2005	This suggests that 5beta-DHP increased iNOS-modulated uterine tone, as occurs during pregnancy.	5-alpha-Dihydroprogesterone	19-28	nitric oxide synthase 2, inducible	Mus musculus	39-43
15796770-3	2005	A previous study from our laboratory has shown that the progesterone metabolites 5beta-pregnane-3,20-dione (5beta-DHP) and 5alpha-pregnan-3alpha-ol,20-one (3alpha,5alpha-THP), as well as dehydroepiandrosterone (DHEA), increase the firing activity of dorsal raphe nucleus (DRN) 5-HT neurones in female rats.	5-alpha-Dihydroprogesterone	81-106	dihydropyrimidinase	Rattus norvegicus	114-117
12416991-4	2002	We report here determination of the kinetic mechanism for 5alpha-DHP reduction catalyzed by human 3alpha-HSD type III by using steady-state kinetics studies and assessment of the ability of fluoxetine and various other small molecules to activate 3alpha-HSD type III catalyzed allopregnanolone formation.	5-alpha-Dihydroprogesterone	58-68	aldo-keto reductase family 1 member C4	Homo sapiens	98-108
15208706-5	2004	Here we show that NP-C mouse brain contains substantially less neurosteroid than wild-type brain and has an age-related decrease in the ability to synthesize 5alpha-dihydroprogesterone and allopregnanolone.	5-alpha-Dihydroprogesterone	158-184	NPC intracellular cholesterol transporter 1	Homo sapiens	18-22
12416991-4	2002	We report here determination of the kinetic mechanism for 5alpha-DHP reduction catalyzed by human 3alpha-HSD type III by using steady-state kinetics studies and assessment of the ability of fluoxetine and various other small molecules to activate 3alpha-HSD type III catalyzed allopregnanolone formation.	5-alpha-Dihydroprogesterone	58-68	aldo-keto reductase family 1 member C4	Homo sapiens	247-257
12416991-7	2002	Two-substrate kinetic analysis and dead-end inhibition studies for 5alpha-DHP reduction and allopregnanolone oxidation indicated that 3alpha-HSD type III utilized a ternary complex (sequential) kinetic mechanism, with nicotinamide adenine dinucleotide cofactor binding before steroid substrate and leaving after steroid product.	5-alpha-Dihydroprogesterone	67-77	aldo-keto reductase family 1 member C4	Homo sapiens	134-144
7593415-4	1995	Concentrations of plasma 5 alpha-dihydroprogesterone were normal in these two women during the luteal phase; this finding implies that circulating 5 alpha-dihydroprogesterone in women is derived principally from the steroid 5 alpha-reductase 1 isoenzyme and leaves unresolved the question of whether 5 alpha-dihydroprogesterone plays a physiological role in women.	5-alpha-Dihydroprogesterone	147-174	steroid 5 alpha-reductase 1	Homo sapiens	216-243
8855816-2	1996	Virtually all of the radioactivity in urine (approximately 37% of the administered dose) was excreted within 72 h. Quantitatively, the 2 major urinary metabolites of 5 alpha-DHP in each of 13 studies conducted in 7 women and 2 men were 3 beta,6 alpha-dihydroxy-5 alpha-pregnan-20-one and 5 alpha-pregnane-3 alpha,20 alpha-diol, which could be extracted after beta-glucuronidase, but not solvolysis, treatment of the urine.	5-alpha-Dihydroprogesterone	166-177	glucuronidase beta	Homo sapiens	359-377
11995921-2	2002	AKR1C1 efficiently reduced 3alpha,5alpha-THP, 5alpha-DHP and progesterone to their 20alpha-hydroxy metabolites, and slowly converted 5alpha-DHDOC to 3alpha,5alpha-THDOC.	5-alpha-Dihydroprogesterone	46-56	aldo-keto reductase family 1 member C1	Homo sapiens	0-6
11995921-3	2002	AKR1C2 exhibited low 20-ketoreductase activity for 3alpha,5alpha-THP and moderate 3-ketoreductase activity for 5alpha-DHP and 5alpha-DHDOC.	5-alpha-Dihydroprogesterone	111-121	aldo-keto reductase family 1 member C2	Homo sapiens	0-6
10557352-6	1999	Our results indicate that the SSRIs fluoxetine, sertraline, and paroxetine decrease the K(m) of the conversion of 5alpha-dihydroprogesterone to allopregnanolone by human 3alpha-HSD type III 10- to 30-fold.	5-alpha-Dihydroprogesterone	114-140	aldo-keto reductase family 1 member C3	Homo sapiens	170-180
9548257-5	1998	These effects are highly steroid- and receptor-specific, because binding and signalling functions of the closely related human OTR are not affected by P4 itself but by the P4 metabolite 5beta-dihydroprogesterone.	5-alpha-Dihydroprogesterone	186-211	oxytocin receptor	Homo sapiens	127-130
7593415-4	1995	Concentrations of plasma 5 alpha-dihydroprogesterone were normal in these two women during the luteal phase; this finding implies that circulating 5 alpha-dihydroprogesterone in women is derived principally from the steroid 5 alpha-reductase 1 isoenzyme and leaves unresolved the question of whether 5 alpha-dihydroprogesterone plays a physiological role in women.	5-alpha-Dihydroprogesterone	147-174	steroid 5 alpha-reductase 1	Homo sapiens	216-243
8245959-2	1993	The major metabolites were 5 alpha-dihydroprogesterone (5 alpha-DHP) and 3 alpha,5 alpha-tetrahydroprogesterone (3 alpha,5 alpha-THP) in rat brain slices, 5 alpha-DHP and 20 alpha-dihydroprogesterone (20 alpha-DHP) in mouse brain slices, and 20 alpha-DHP in monkey brain slices.	5-alpha-Dihydroprogesterone	27-54	dihydropyrimidinase	Rattus norvegicus	64-67
8499336-2	1993	By altering the 3 alpha-HSOR catalyzed conversion of 5 alpha-dihydroprogesterone (5 alpha-DHP) to 3 alpha,5 alpha-tetrahydroprogesterone (3 alpha,5 alpha-THP), these barbiturates could influence the in situ production of 3 alpha,5 alpha-THP.	5-alpha-Dihydroprogesterone	53-80	dihydropyrimidinase	Rattus norvegicus	90-93
8408469-1	1993	This study was conducted 1) to ascertain whether the high levels of plasma 5 alpha-dihydroprogesterone (5 alpha DHP) during the luteal phase of the human ovarian cycle and pregnancy are attributable to high rates of production or, alternatively, low rates of clearance, and 2) to estimate the relative distribution of the irreversible metabolism of 5 alpha DHP, i.e. hepatic compared with extrahepatic clearance of plasma 5 alpha DHP.	5-alpha-Dihydroprogesterone	75-102	dihydropyrimidinase	Homo sapiens	112-115
1795296-1	1991	Changes in the progesterone metabolite 5 alpha-dihydroprogesterone (5 alpha-DHP) in maternal plasma in late gestation, and possible sites of production of this steroid were studied in pony and Thoroughbred mares by an enzyme-linked immunosorbant assay for 5 alpha-DHP.	5-alpha-Dihydroprogesterone	39-66	dihydropyrimidinase	Homo sapiens	76-79
1664743-9	1991	The effect of 5 beta-pregnane-3,20-dione and progesterone was effectively blocked by RU486 but not by picrotoxin, suggesting that their actions were mediated through the progesterone receptor system.	5-alpha-Dihydroprogesterone	14-40	progesterone receptor	Rattus norvegicus	170-191
2095353-5	1990	Thus, after 3 beta-HSD-catalyzed formation from pregnenolone, progesterone was efficiently converted to 5 alpha-pregnan-3,20-dione (5 alpha-dihydroprogesterone) and subsequent metabolism to the corresponding 17 alpha-hydroxylated derivative and 5 alpha-androstan-3,17-dione in a reaction catalyzed by P-450(17) alpha.	5-alpha-Dihydroprogesterone	132-159	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	12-22
2095353-5	1990	Thus, after 3 beta-HSD-catalyzed formation from pregnenolone, progesterone was efficiently converted to 5 alpha-pregnan-3,20-dione (5 alpha-dihydroprogesterone) and subsequent metabolism to the corresponding 17 alpha-hydroxylated derivative and 5 alpha-androstan-3,17-dione in a reaction catalyzed by P-450(17) alpha.	5-alpha-Dihydroprogesterone	132-159	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	301-316
19215357-11	1990	The effect of 5alpha-dihydroprogesterone required estrogen priming and was blocked by the antiprogestin, RU486, suggesting progesterone receptor mediation.	5-alpha-Dihydroprogesterone	14-40	progesterone receptor	Homo sapiens	123-144
2359812-1	1990	Progesterone and 5 alpha-pregnane-3,20-dione (5 alpha-DHP) concentrations were measured in seven brain areas and in plasma during "anesthesia" induced by progesterone (1-2 mg IV) in female rats.	5-alpha-Dihydroprogesterone	17-44	dihydropyrimidinase	Rattus norvegicus	54-57