PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34001596-2 2021 Genetic experiments have shown that phosphatidylinositol 5-phosphate 4-kinase alpha and beta (PI5P4Kalpha and PI5P4Kbeta) are essential for the development of late-onset tumors in mice with germline p53 deletion, but the mechanism underlying this acquired dependence remains unclear. phosphatidylinositol 5-phosphate 36-68 phosphatidylinositol-5-phosphate 4-kinase, type II, beta Mus musculus 110-120 34001596-2 2021 Genetic experiments have shown that phosphatidylinositol 5-phosphate 4-kinase alpha and beta (PI5P4Kalpha and PI5P4Kbeta) are essential for the development of late-onset tumors in mice with germline p53 deletion, but the mechanism underlying this acquired dependence remains unclear. phosphatidylinositol 5-phosphate 36-68 transformation related protein 53, pseudogene Mus musculus 199-202 33117337-4 2020 Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity. phosphatidylinositol 5-phosphate 63-67 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 50-53 33117337-4 2020 Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity. phosphatidylinositol 5-phosphate 63-67 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 69-77 33117337-4 2020 Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity. phosphatidylinositol 5-phosphate 63-67 CF transmembrane conductance regulator Homo sapiens 261-320 33117337-4 2020 Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity. phosphatidylinositol 5-phosphate 63-67 CF transmembrane conductance regulator Homo sapiens 322-326 32407779-7 2020 The hAPT1 domain binds, in addition to PI3P, to phosphatidylinositol 5-phosphate (PI5P). phosphatidylinositol 5-phosphate 48-80 lysophospholipase 1 Homo sapiens 4-9 32407779-7 2020 The hAPT1 domain binds, in addition to PI3P, to phosphatidylinositol 5-phosphate (PI5P). phosphatidylinositol 5-phosphate 82-86 lysophospholipase 1 Homo sapiens 4-9 31888228-3 2019 Here, we show that Vav1, a protein that exhibits both Rac1 GDP/GTP exchange and adaptor activities, is positively modulated by PI5P and, possibly, other mono-PIs. phosphatidylinositol 5-phosphate 127-131 vav guanine nucleotide exchange factor 1 Homo sapiens 19-23 31967472-1 2020 Inositol polyphosphate 5-phosphatase (OCRL-1) participates in the regulation of multiple cellular processes, through the conversion of phosphatidylinositol 4,5-phosphate to phosphatidylinositol 4-phosphate. phosphatidylinositol 5-phosphate 135-169 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 38-44 31888228-3 2019 Here, we show that Vav1, a protein that exhibits both Rac1 GDP/GTP exchange and adaptor activities, is positively modulated by PI5P and, possibly, other mono-PIs. phosphatidylinositol 5-phosphate 127-131 Rac family small GTPase 1 Homo sapiens 54-58 31329883-1 2019 TMEM55B is first identified as phosphatidylinositol-4,5-P24-phosphatases (PtdIns-4,5-P24-phosphatases) that catalyse dephosphorylation of PtdIns-4,5-P2 to PtdIns-5-P. phosphatidylinositol 5-phosphate 155-165 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Homo sapiens 0-7 31313076-2 2019 SAC3/FIG4 is a phosphatase that not only turns over PtdIns(3,5)P2 to PtdIns3P but also promotes PtdIns(3,5)P2 synthesis by activating the PIKFYVE kinase that also makes PtdIns5P. phosphatidylinositol 5-phosphate 169-177 FIG4 phosphoinositide 5-phosphatase Homo sapiens 0-4 31313076-3 2019 Whether CMT4J patients have alterations in PtdIns(3,5)P2, PtdIns5P or in other phosphoinositides (PIs), and if yes, in what direction these changes might be, has never been examined. phosphatidylinositol 5-phosphate 58-66 FIG4 phosphoinositide 5-phosphatase Homo sapiens 8-13 31313076-7 2019 Compared to normal human controls (n = 9), both PtdIns(3,5)P2 and PtdIns5P levels were significantly decreased in CMT4J fibroblasts (n = 13) by 36.4 +- 3.6% and 43.1 +- 4.4%, respectively (p < 0.0001). phosphatidylinositol 5-phosphate 66-74 FIG4 phosphoinositide 5-phosphatase Homo sapiens 114-119 31628917-1 2019 Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. phosphatidylinositol 5-phosphate 67-75 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 128-135 31652444-8 2019 Finally, we demonstrate the use of this technique to quantify elevations in PI5P levels, from Drosophila larval tissues and cultured cells depleted of phosphatidylinositol 5 phosphate 4-kinase (PIP4K), that metabolizes PI5P into PI(4,5)P2 thus regulating its levels. phosphatidylinositol 5-phosphate 76-80 Phosphatidylinositol 5-phosphate 4-kinase Drosophila melanogaster 151-192 31652444-8 2019 Finally, we demonstrate the use of this technique to quantify elevations in PI5P levels, from Drosophila larval tissues and cultured cells depleted of phosphatidylinositol 5 phosphate 4-kinase (PIP4K), that metabolizes PI5P into PI(4,5)P2 thus regulating its levels. phosphatidylinositol 5-phosphate 219-223 Phosphatidylinositol 5-phosphate 4-kinase Drosophila melanogaster 151-192 31652444-8 2019 Finally, we demonstrate the use of this technique to quantify elevations in PI5P levels, from Drosophila larval tissues and cultured cells depleted of phosphatidylinositol 5 phosphate 4-kinase (PIP4K), that metabolizes PI5P into PI(4,5)P2 thus regulating its levels. phosphatidylinositol 5-phosphate 219-223 Phosphatidylinositol 5-phosphate 4-kinase Drosophila melanogaster 194-199 32291040-2 2018 Two Arabidopsis genes, AtMTM1 and AtMTM2, encode enzymatically active phosphatases but although AtMTM1 deficiency results in increased tolerance to dehydration stress and a decrease in cellular PtdIns5P, the role of AtMTM2 is less clear, as it does not contribute to the PtdIns5P pool upon dehydration stress. phosphatidylinositol 5-phosphate 194-202 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 96-102 30944173-5 2019 Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3" position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P2 and PtdIns from PtdIns3P. phosphatidylinositol 5-phosphate 222-230 stimulator of interferon response cGAMP interactor 1 Homo sapiens 19-24 30944173-5 2019 Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3" position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P2 and PtdIns from PtdIns3P. phosphatidylinositol 5-phosphate 222-230 myotubularin related protein 3 Homo sapiens 53-90 30944173-5 2019 Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3" position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P2 and PtdIns from PtdIns3P. phosphatidylinositol 5-phosphate 222-230 myotubularin related protein 4 Homo sapiens 95-100 32291040-2 2018 Two Arabidopsis genes, AtMTM1 and AtMTM2, encode enzymatically active phosphatases but although AtMTM1 deficiency results in increased tolerance to dehydration stress and a decrease in cellular PtdIns5P, the role of AtMTM2 is less clear, as it does not contribute to the PtdIns5P pool upon dehydration stress. phosphatidylinositol 5-phosphate 271-279 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 23-29 32291040-2 2018 Two Arabidopsis genes, AtMTM1 and AtMTM2, encode enzymatically active phosphatases but although AtMTM1 deficiency results in increased tolerance to dehydration stress and a decrease in cellular PtdIns5P, the role of AtMTM2 is less clear, as it does not contribute to the PtdIns5P pool upon dehydration stress. phosphatidylinositol 5-phosphate 271-279 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 34-40 32291040-2 2018 Two Arabidopsis genes, AtMTM1 and AtMTM2, encode enzymatically active phosphatases but although AtMTM1 deficiency results in increased tolerance to dehydration stress and a decrease in cellular PtdIns5P, the role of AtMTM2 is less clear, as it does not contribute to the PtdIns5P pool upon dehydration stress. phosphatidylinositol 5-phosphate 271-279 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 96-102 32291040-3 2018 Here we analysed the involvement of AtMTM1, AtMTM2 and PtdIns5P in the response of Arabidopsis seedlings to dehydration stress/ABA, and found that both AtMTM1 and AtMTM2 were involved but affected oppositely stomata movement and the accumulation of reactive oxygen species (ROS, e.g. H2O2). phosphatidylinositol 5-phosphate 55-63 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 163-169 28253962-2 2017 This process is initiated by specific phosphoinositides, PtdIns3P and PtdIns5P, which play a key role in autophagy by recruiting effectors such as Atg18/WIPI2. phosphatidylinositol 5-phosphate 70-78 WD repeat domain, phosphoinositide interacting 1 Homo sapiens 147-152 28857423-1 2017 The protein complex composed of the kinase PIKfyve, the phosphatase FIG4 and the scaffolding protein VAC14 regulates the metabolism of phosphatidylinositol 3,5-bisphosphate, which serves as both a signaling lipid and the major precursor for phosphatidylinositol 5-phosphate. phosphatidylinositol 5-phosphate 241-273 VAC14 component of PIKFYVE complex Homo sapiens 101-106 28779020-11 2017 This is consistent with observations in nonleukocytes that showed that PIKfyve and PtdIns(5)P control Rac and cell migration. phosphatidylinositol 5-phosphate 83-93 AKT serine/threonine kinase 1 Homo sapiens 102-105 28253962-2 2017 This process is initiated by specific phosphoinositides, PtdIns3P and PtdIns5P, which play a key role in autophagy by recruiting effectors such as Atg18/WIPI2. phosphatidylinositol 5-phosphate 70-78 WD repeat domain, phosphoinositide interacting 2 Homo sapiens 153-158 27417143-0 2016 Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV. phosphatidylinositol 5-phosphate 44-76 septin 9 Homo sapiens 0-8 27514935-5 2016 Enzymatic cleavage of cell surface PIP2 or decreased cellular PIP2 by knockdown of phosphatidylinositol-5-phosphate 4-kinase impaired apoA1 binding and cholesterol efflux to apoA1. phosphatidylinositol 5-phosphate 83-115 apolipoprotein A-I Mus musculus 134-139 27514935-5 2016 Enzymatic cleavage of cell surface PIP2 or decreased cellular PIP2 by knockdown of phosphatidylinositol-5-phosphate 4-kinase impaired apoA1 binding and cholesterol efflux to apoA1. phosphatidylinositol 5-phosphate 83-115 apolipoprotein A-I Mus musculus 174-179 27417143-6 2016 The effects of septin 9 on LDs are also dependent on binding to PtdIns5P, which, in turn, controls the formation of septin 9 filaments and its interaction with microtubules. phosphatidylinositol 5-phosphate 64-72 septin 9 Homo sapiens 15-23 27417143-6 2016 The effects of septin 9 on LDs are also dependent on binding to PtdIns5P, which, in turn, controls the formation of septin 9 filaments and its interaction with microtubules. phosphatidylinositol 5-phosphate 64-72 septin 9 Homo sapiens 116-124 27417143-8 2016 Overall, our data offer a novel route for LD growth through the involvement of a septin 9/PtdIns5P signalling pathway. phosphatidylinositol 5-phosphate 90-98 septin 9 Homo sapiens 81-89 27311358-5 2016 Biochemical analysis showed that GhLTPG1 specifically bound to phosphatidylinositol mono-phosphates (PtdIns3P, PtdIns4P and PtdIns5P) in vitro and transported PtdInsPs from the synthesis places to the plasma membranes in vivo. phosphatidylinositol 5-phosphate 124-132 non-specific lipid transfer protein GPI-anchored 1 Gossypium hirsutum 33-40 24681948-3 2015 One of these, the lipid kinase phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP4K2A) regulates cellular levels of phosphatidylinositol-5-phosphate (PtsIns5P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). phosphatidylinositol 5-phosphate 31-63 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Homo sapiens 90-97 26227852-1 2015 PIP4K2A is a lipid kinase that phosphorylates PtdIns5P, generating PtdIns4,5P2. phosphatidylinositol 5-phosphate 46-54 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Homo sapiens 0-7 27132569-0 2016 PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis. phosphatidylinositol 5-phosphate 33-41 phosphatidylinositol-5-phosphate 4-kinase type 2 beta Homo sapiens 0-7 27132569-3 2016 show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth. phosphatidylinositol 5-phosphate 150-158 phosphatidylinositol-5-phosphate 4-kinase type 2 beta Homo sapiens 10-17 26862219-6 2016 In the present study I outline how changes in the levels of the nuclear phosphoinositide PtdIns5P impact on muscle cell differentiation through the PHD finger of TAF3 (TAF, TATA box binding protein (TBP)-associated factor), which is a core component of a number of different basal transcription complexes. phosphatidylinositol 5-phosphate 89-97 TATA-box binding protein associated factor 3 Homo sapiens 162-166 26862219-6 2016 In the present study I outline how changes in the levels of the nuclear phosphoinositide PtdIns5P impact on muscle cell differentiation through the PHD finger of TAF3 (TAF, TATA box binding protein (TBP)-associated factor), which is a core component of a number of different basal transcription complexes. phosphatidylinositol 5-phosphate 89-97 TATA-box binding protein associated factor 8 Homo sapiens 162-165 25619930-9 2015 Concordantly, Vps34KO podocytes had severely reduced steady-state levels of both PtdIns(3,5)P2 and PtdIns5P, along with PtdIns3P. phosphatidylinositol 5-phosphate 99-107 phosphatidylinositol 3-kinase catalytic subunit type 3 Mus musculus 14-19 24813945-0 2014 Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. phosphatidylinositol 5-phosphate 94-126 ubiquitin like with PHD and ring finger domains 1 Homo sapiens 57-62 25720158-7 2014 Lipid overlay assay showed that (PX-BAR)SNX7 can bind to PtdIns(5)P, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. phosphatidylinositol 5-phosphate 57-67 sorting nexin 7 Danio rerio 40-44 24840251-0 2014 PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. phosphatidylinositol 5-phosphate 33-41 Rac family small GTPase 1 Homo sapiens 108-112 24840251-1 2014 Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. phosphatidylinositol 5-phosphate 211-219 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 73-80 24840251-1 2014 Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. phosphatidylinositol 5-phosphate 211-219 myotubularin related protein 3 Homo sapiens 137-142 24840251-1 2014 Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. phosphatidylinositol 5-phosphate 211-219 myotubularin related protein 3 Homo sapiens 144-174 24840251-7 2014 Further experiments also implicated PtdIns5P in the activation of Rac1. phosphatidylinositol 5-phosphate 36-44 Rac family small GTPase 1 Homo sapiens 66-70 24840251-8 2014 The results suggest a model for the activation of Rac1 in cell migration where PIKfyve and MTMR3 produce PtdIns5P on cellular membranes which may then serve to recruit effectors to activate Rac1. phosphatidylinositol 5-phosphate 105-113 Rac family small GTPase 1 Homo sapiens 50-54 24840251-8 2014 The results suggest a model for the activation of Rac1 in cell migration where PIKfyve and MTMR3 produce PtdIns5P on cellular membranes which may then serve to recruit effectors to activate Rac1. phosphatidylinositol 5-phosphate 105-113 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 79-86 24840251-8 2014 The results suggest a model for the activation of Rac1 in cell migration where PIKfyve and MTMR3 produce PtdIns5P on cellular membranes which may then serve to recruit effectors to activate Rac1. phosphatidylinositol 5-phosphate 105-113 myotubularin related protein 3 Homo sapiens 91-96 24840251-8 2014 The results suggest a model for the activation of Rac1 in cell migration where PIKfyve and MTMR3 produce PtdIns5P on cellular membranes which may then serve to recruit effectors to activate Rac1. phosphatidylinositol 5-phosphate 105-113 Rac family small GTPase 1 Homo sapiens 190-194 24950375-2 2014 (2014) identify the signaling molecule phosphatidylinositol 5-phosphate (PI5P) as an allosteric regulator that determines the mode of chromatin binding for the DNA methylation maintenance factor Uhrf1. phosphatidylinositol 5-phosphate 39-71 ubiquitin like with PHD and ring finger domains 1 Homo sapiens 195-200 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 30-62 interferon regulatory factor 3 Mus musculus 160-164 24905281-0 2014 Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1. phosphatidylinositol 5-phosphate 0-32 TIAM Rac1 associated GEF 1 Homo sapiens 86-91 24905281-2 2014 Here, we show that PtdIns5P regulates actin dynamics and invasion via recruitment and activation of the exchange factor Tiam1 and Rac1. phosphatidylinositol 5-phosphate 19-27 TIAM Rac1 associated GEF 1 Homo sapiens 120-125 24905281-2 2014 Here, we show that PtdIns5P regulates actin dynamics and invasion via recruitment and activation of the exchange factor Tiam1 and Rac1. phosphatidylinositol 5-phosphate 19-27 Rac family small GTPase 1 Homo sapiens 130-134 24905281-3 2014 Restricted Rac1 activation results from the binding of Tiam1 DH-PH domains to PtdIns5P. phosphatidylinositol 5-phosphate 78-86 Rac family small GTPase 1 Homo sapiens 11-15 24905281-3 2014 Restricted Rac1 activation results from the binding of Tiam1 DH-PH domains to PtdIns5P. phosphatidylinositol 5-phosphate 78-86 TIAM Rac1 associated GEF 1 Homo sapiens 55-60 24905281-4 2014 Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment. phosphatidylinositol 5-phosphate 210-218 TIAM Rac1 associated GEF 1 Homo sapiens 152-157 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 30-62 TANK-binding kinase 1 Mus musculus 189-193 24127122-1 2013 Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase beta (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2]. phosphatidylinositol 5-phosphate 0-32 phosphatidylinositol-5-phosphate 4-kinase type 2 beta Homo sapiens 59-66 24127122-1 2013 Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase beta (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2]. phosphatidylinositol 5-phosphate 34-42 phosphatidylinositol-5-phosphate 4-kinase type 2 beta Homo sapiens 59-66 24127122-1 2013 Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase beta (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2]. phosphatidylinositol 5-phosphate 151-159 phosphatidylinositol-5-phosphate 4-kinase type 2 beta Homo sapiens 59-66 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 30-62 TANK-binding kinase 1 Mus musculus 208-212 23602596-6 2013 We show that exposure of cells to UV irradiation or hydrogen peroxide (H2O2), induces the synthesis of the phosphoinositide second messenger PtdIns5P in part by inducing the interaction between phosphatidylinositol-5-phosphate 4-kinase (PIP4K) enzymes that remove PtdIns5P, with Pin1. phosphatidylinositol 5-phosphate 141-149 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 279-283 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 30-62 interferon regulatory factor 3 Mus musculus 222-226 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 64-72 interferon regulatory factor 3 Mus musculus 160-164 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 64-72 TANK-binding kinase 1 Mus musculus 189-193 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 64-72 TANK-binding kinase 1 Mus musculus 208-212 23954154-2 2013 We demonstrate that the lipid phosphatidylinositol-5-phosphate (PtdIns5P) is increased upon viral infection and facilitates type I IFN production by binding to IRF3 and its upstream kinase TBK1 and promoting TBK1-mediated IRF3 phosphorylation and activation. phosphatidylinositol 5-phosphate 64-72 interferon regulatory factor 3 Mus musculus 222-226 23954154-5 2013 A synthetic PtdIns5P, C8-PtdIns5P, promotes IRF3 phosphorylation and cytokine production in dendritic cells and acts as an adjuvant to boost immune responses in immunized mice. phosphatidylinositol 5-phosphate 12-20 interferon regulatory factor 3 Mus musculus 44-48 23954154-5 2013 A synthetic PtdIns5P, C8-PtdIns5P, promotes IRF3 phosphorylation and cytokine production in dendritic cells and acts as an adjuvant to boost immune responses in immunized mice. phosphatidylinositol 5-phosphate 25-33 interferon regulatory factor 3 Mus musculus 44-48 23954154-6 2013 Thus, PtdIns5P produced during viral infection is a second messenger that targets the TBK1-IRF3 axis to elicit antiviral immunity. phosphatidylinositol 5-phosphate 6-14 TANK-binding kinase 1 Mus musculus 86-90 23954154-6 2013 Thus, PtdIns5P produced during viral infection is a second messenger that targets the TBK1-IRF3 axis to elicit antiviral immunity. phosphatidylinositol 5-phosphate 6-14 interferon regulatory factor 3 Mus musculus 91-95 23673157-1 2013 The evolutionarily conserved kinase PIKfyve that synthesizes PtdIns5P and PtdIns(3,5)P2 has been implicated in insulin-regulated GLUT4 translocation/glucose entry in 3T3-L1 adipocytes. phosphatidylinositol 5-phosphate 61-69 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 129-134 23602596-7 2013 In response to H2O2 exposure, Murine Embryonic Fibroblasts (MEFs) derived from Pin1-/- mice showed increased cell viability and an increased abundance of PtdIns5P compared to wild-type MEFs. phosphatidylinositol 5-phosphate 154-162 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 79-83 23602596-8 2013 Decreasing the levels of PtdIns5P in Pin1-/- MEFs decreased both their viability in response to H2O2 exposure and the expression of genes required for cellular ROS management. phosphatidylinositol 5-phosphate 25-33 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 37-41 23241309-0 2013 PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation. phosphatidylinositol 5-phosphate 0-8 protein tyrosine kinase 2 beta Homo sapiens 72-75 23241309-5 2013 In response to hydrogen peroxide (H2O2), we measured an increase in PtdIns5P in cells derived from human osteosarcoma, U2OS (5-fold); breast tumors, MDA-MB-468 (2-fold); and fibrosarcoma, HT1080 (3-fold); and in p53-null murine embryonic fibroblasts (8-fold). phosphatidylinositol 5-phosphate 68-76 tumor protein p53 Homo sapiens 212-215 23241309-7 2013 A reduction in H2O2-induced PtdIns5P levels by the overexpression of PIP4K revealed its role in PKB activation. phosphatidylinositol 5-phosphate 28-36 protein tyrosine kinase 2 beta Homo sapiens 96-99 23241309-8 2013 Suppression of H2O2-induced PtdIns5P generation reduced PKB activation and, surprisingly, reduced cell sensitivity to growth inhibition by H2O2. phosphatidylinositol 5-phosphate 28-36 protein tyrosine kinase 2 beta Homo sapiens 56-59 23193159-0 2012 Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress. phosphatidylinositol 5-phosphate 14-46 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 60-64 23823870-3 2013 Here we provide evidence that direct association of ING2 with the nuclear phosphoinositide phosphatidylinositol-5-phosphate (PtdIns(5)P) regulates a subset of ING2 targets in response to DNA damage. phosphatidylinositol 5-phosphate 125-135 inhibitor of growth family member 2 Homo sapiens 52-56 23823870-3 2013 Here we provide evidence that direct association of ING2 with the nuclear phosphoinositide phosphatidylinositol-5-phosphate (PtdIns(5)P) regulates a subset of ING2 targets in response to DNA damage. phosphatidylinositol 5-phosphate 125-135 inhibitor of growth family member 2 Homo sapiens 159-163 23823870-4 2013 At these target genes, the binding event between ING2 and PtdIns(5)P is required for ING2 promoter occupancy and ING2-associated gene repression. phosphatidylinositol 5-phosphate 58-68 inhibitor of growth family member 2 Homo sapiens 49-53 23823870-4 2013 At these target genes, the binding event between ING2 and PtdIns(5)P is required for ING2 promoter occupancy and ING2-associated gene repression. phosphatidylinositol 5-phosphate 58-68 inhibitor of growth family member 2 Homo sapiens 85-89 23823870-4 2013 At these target genes, the binding event between ING2 and PtdIns(5)P is required for ING2 promoter occupancy and ING2-associated gene repression. phosphatidylinositol 5-phosphate 58-68 inhibitor of growth family member 2 Homo sapiens 85-89 23823870-5 2013 Moreover, depletion of PtdIns(5)P attenuates ING2-mediated regulation of these targets in the presence of DNA damage. phosphatidylinositol 5-phosphate 23-33 inhibitor of growth family member 2 Homo sapiens 45-49 23823870-6 2013 Taken together, these findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites. phosphatidylinositol 5-phosphate 56-66 inhibitor of growth family member 2 Homo sapiens 129-133 23823870-0 2013 Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. phosphatidylinositol 5-phosphate 8-40 inhibitor of growth family member 2 Homo sapiens 51-55 23193159-4 2012 We found that the abundance of phosphatidylinositol-5-phosphate (PtdIns5P) was increased in response to H(2)O(2), an effect that was enhanced in Pin1(-/-) MEFs. phosphatidylinositol 5-phosphate 31-63 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 145-149 23193159-4 2012 We found that the abundance of phosphatidylinositol-5-phosphate (PtdIns5P) was increased in response to H(2)O(2), an effect that was enhanced in Pin1(-/-) MEFs. phosphatidylinositol 5-phosphate 65-73 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 145-149 23193159-5 2012 Reduction of H(2)O(2)-induced PtdIns5P compromised cell viability in response to oxidative stress, suggesting that PtdIns5P contributed to the enhanced cell viability of Pin1(-/-) MEFs exposed to oxidative stress. phosphatidylinositol 5-phosphate 30-38 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 170-174 23193159-5 2012 Reduction of H(2)O(2)-induced PtdIns5P compromised cell viability in response to oxidative stress, suggesting that PtdIns5P contributed to the enhanced cell viability of Pin1(-/-) MEFs exposed to oxidative stress. phosphatidylinositol 5-phosphate 115-123 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 170-174 23193159-6 2012 The increased PtdIns5P in the Pin1(-/-) MEFs stimulated the expression of genes involved in defense against oxidative stress and reduced the accumulation of reactive oxygen species. phosphatidylinositol 5-phosphate 14-22 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 30-34 23193159-8 2012 Although reintroduction of Pin1 into the Pin1(-/-) MEFs reduced the amount of PtdIns5P produced in response to H(2)O(2), in vitro assays indicated that the isomerase activity of Pin1 inhibited PIP4K activity. phosphatidylinositol 5-phosphate 78-86 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 27-31 23193159-8 2012 Although reintroduction of Pin1 into the Pin1(-/-) MEFs reduced the amount of PtdIns5P produced in response to H(2)O(2), in vitro assays indicated that the isomerase activity of Pin1 inhibited PIP4K activity. phosphatidylinositol 5-phosphate 78-86 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 41-45 23193159-8 2012 Although reintroduction of Pin1 into the Pin1(-/-) MEFs reduced the amount of PtdIns5P produced in response to H(2)O(2), in vitro assays indicated that the isomerase activity of Pin1 inhibited PIP4K activity. phosphatidylinositol 5-phosphate 78-86 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 41-45 22647598-8 2012 In cells, the MTMR6/R9 complex significantly increases the cellular levels of PtdIns(5)P, the product of PI(3,5)P(2) dephosphorylation, whereas the MTMR8/R9 complex reduces cellular PtdIns(3)P levels. phosphatidylinositol 5-phosphate 78-88 myotubularin related protein 6 Homo sapiens 14-19 22621786-9 2012 The results provide the first experimental evidence that the principal pathway for PtdIns5P intracellular production is through PIKfyve and that insulin effect on actin stress fiber disassembly is mediated entirely by the PIKfyve-produced PtdIns5P pool. phosphatidylinositol 5-phosphate 239-247 insulin Cricetulus griseus 145-152 22324391-9 2012 However, only AtMTM1 is involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydration stress, and the two myotubularins differentially affect the Arabidopsis dehydration stress-responding transcriptome. phosphatidylinositol 5-phosphate 68-100 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 14-20 21847559-0 2011 Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle. phosphatidylinositol 5-phosphate 15-47 insulin Homo sapiens 51-58 23086417-6 2012 This chapter summarizes our current knowledge of the diverse and complex functionality of PIKfyve and PtdIns(3,5)P2/PtdIns5P products with particular highlights on recent discoveries of inherited or somatic mutations in PIKfyve and Sac3 linked to human disorders. phosphatidylinositol 5-phosphate 116-124 FIG4 phosphoinositide 5-phosphatase Homo sapiens 232-236 23086420-3 2012 Such catalytic site characterizes the myotubularin 3-phosphatases that dephosphorylate PtdIns3P and PtdIns(3,5)P2 and produce PtdIns5P. phosphatidylinositol 5-phosphate 126-134 myotubularin 1 Homo sapiens 38-50 21847559-6 2011 Our results are consistent with a role for insulin-stimulated PtdIns5P production in regulating glucose transport by promoting PI 3-kinase signalling. phosphatidylinositol 5-phosphate 62-70 insulin Homo sapiens 43-50 21847559-1 2011 The phosphoinositide phospholipid PtdIns5P has previously been implicated in insulin-stimulated translocation of the glucose transporter GLUT4 into the plasma membrane of adipocytes, but its potential role in glucose transport in muscle has not been explored. phosphatidylinositol 5-phosphate 34-42 insulin Homo sapiens 77-84 21847559-1 2011 The phosphoinositide phospholipid PtdIns5P has previously been implicated in insulin-stimulated translocation of the glucose transporter GLUT4 into the plasma membrane of adipocytes, but its potential role in glucose transport in muscle has not been explored. phosphatidylinositol 5-phosphate 34-42 solute carrier family 2 member 4 Homo sapiens 137-142 21847559-2 2011 The involvement of PtdIns5P in insulin-stimulated glucose uptake was therefore investigated in myotubes of the skeletal muscle cell line L6. phosphatidylinositol 5-phosphate 19-27 insulin Homo sapiens 31-38 21847559-3 2011 Stimulation with insulin produced a transient increase in PtdIns5P, which was abolished by the over-expression of the highly active PtdIns5P 4-kinase PIP4Kalpha. phosphatidylinositol 5-phosphate 58-66 insulin Homo sapiens 17-24 21847559-5 2011 Delivery of exogenous PtdIns5P into unstimulated myotubes increased Akt phosphorylation, promoted GLUT4 relocalisation from internal membrane to plasma membrane fractions and its association with plasma membrane lawns and also stimulated glucose uptake in a tyrosine kinase and phosphoinositide 3-kinase (PI 3-kinase)-dependent fashion. phosphatidylinositol 5-phosphate 22-30 solute carrier family 2 member 4 Homo sapiens 98-103 21737449-3 2011 We demonstrated previously that the high level of phosphatidylinositol 5-phosphate measured in NPM-ALK-expressing cells is controlled by the phosphoinositide kinase PIKfyve, a lipid kinase known for its role in vesicular trafficking. phosphatidylinositol 5-phosphate 50-82 nucleophosmin 1 Homo sapiens 95-98 21934107-2 2011 Shigella flexneri, a bacterium that causes dysentery, injects IpgD, a phosphoinositide phosphatase that generates the lipid phosphatidylinositol 5-phosphate (PI5P), into host cells, thereby activating the phosphoinositide 3-kinase-Akt survival pathway. phosphatidylinositol 5-phosphate 158-162 AKT serine/threonine kinase 1 Homo sapiens 231-234 21934107-4 2011 Cells treated with PI5P had increased numbers of early endosomes with activated EGFR, no detectable EGFR in the late endosomal or lysosomal compartments, and prolonged EGFR signaling. phosphatidylinositol 5-phosphate 19-23 epidermal growth factor receptor Homo sapiens 80-84 21934107-4 2011 Cells treated with PI5P had increased numbers of early endosomes with activated EGFR, no detectable EGFR in the late endosomal or lysosomal compartments, and prolonged EGFR signaling. phosphatidylinositol 5-phosphate 19-23 epidermal growth factor receptor Homo sapiens 100-104 21934107-4 2011 Cells treated with PI5P had increased numbers of early endosomes with activated EGFR, no detectable EGFR in the late endosomal or lysosomal compartments, and prolonged EGFR signaling. phosphatidylinositol 5-phosphate 19-23 epidermal growth factor receptor Homo sapiens 100-104 21737449-3 2011 We demonstrated previously that the high level of phosphatidylinositol 5-phosphate measured in NPM-ALK-expressing cells is controlled by the phosphoinositide kinase PIKfyve, a lipid kinase known for its role in vesicular trafficking. phosphatidylinositol 5-phosphate 50-82 ALK receptor tyrosine kinase Homo sapiens 99-102 21628641-4 2011 PSP binds PtdIns(3,4)P(2), 10-fold greater than PtdIns(3,5)P(2) or PtdIns(4)P, and does not bind PtdIns(3)P or PtdIns(5)P. phosphatidylinositol 5-phosphate 111-121 BPI fold containing family A, member 2 Rattus norvegicus 0-3 21609323-4 2011 The PIPs that interact with EWI2 cytoplasmic tail include PtdIns5P, PtdIns4P, PtdIns3P, PtdIns(3,5)P(2) and PtdIns(3,4)P2. phosphatidylinositol 5-phosphate 58-66 immunoglobulin superfamily member 8 Homo sapiens 28-32 21609323-5 2011 The binding affinity of PIPs to the EWI2 tail, however, is not solely based on charge because PtdIns5P, PtdIns4P and PtdIns3P have a higher affinity to EWI2 than PtdIns(3,5)P(2) and PtdIns(3,4)P(2) do. phosphatidylinositol 5-phosphate 94-102 immunoglobulin superfamily member 8 Homo sapiens 36-40 21609323-5 2011 The binding affinity of PIPs to the EWI2 tail, however, is not solely based on charge because PtdIns5P, PtdIns4P and PtdIns3P have a higher affinity to EWI2 than PtdIns(3,5)P(2) and PtdIns(3,4)P(2) do. phosphatidylinositol 5-phosphate 94-102 immunoglobulin superfamily member 8 Homo sapiens 152-156 21730175-5 2011 We also determined the structure of the catalytically inactive phosphatase in complex with a surrogate substrate, phosphatidylinositol 5-phosphate, which sheds light on the substrate recognition and specificity of PTPMT1. phosphatidylinositol 5-phosphate 114-146 protein tyrosine phosphatase mitochondrial 1 Homo sapiens 214-220 21543646-5 2011 In this study, we report that these basic amino acids enable CD3 zeta to complex the phosphoinositides PtdIns(3)P, PtdIns(4)P, PtdIns(5)P, PtdIns(3,5)P(2), and PtdIns(3,4,5)P(3) with high affinity. phosphatidylinositol 5-phosphate 127-137 CD247 molecule Homo sapiens 61-69 21623381-8 2011 BIN1 missplicing results in expression of an inactive form of BIN1 lacking phosphatidylinositol 5-phosphate-binding and membrane-tubulating activities. phosphatidylinositol 5-phosphate 75-107 bridging integrator 1 Homo sapiens 0-4 21623381-8 2011 BIN1 missplicing results in expression of an inactive form of BIN1 lacking phosphatidylinositol 5-phosphate-binding and membrane-tubulating activities. phosphatidylinositol 5-phosphate 75-107 bridging integrator 1 Homo sapiens 62-66 20967218-0 2010 Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1. phosphatidylinositol 5-phosphate 0-32 homolog of anti-oxidant 1 Arabidopsis thaliana 111-115 21349843-2 2011 In mammals, PIKfyve synthesizes PtdIns(3,5)P(2) and PtdIns5P lipids that regulate endosomal trafficking and responses to extracellular stimuli. phosphatidylinositol 5-phosphate 52-60 phosphoinositide kinase, FYVE type zinc finger containing Mus musculus 12-19 21349843-9 2011 Consistently, steady-state levels of the PIKfyve products PtdIns(3,5)P(2) and PtdIns5P selectively decreased, but this reduction (35-40%) was 10-15% less than that expected based on PIKfyve protein reduction. phosphatidylinositol 5-phosphate 78-86 phosphoinositide kinase, FYVE type zinc finger containing Mus musculus 41-48 21349843-10 2011 The nonlinear decrease of the PIKfyve protein versus PIKfyve lipid products, the potential mechanism(s) discussed herein, may explain how one functional allele in PIKfyve(WT/KO) mice is able to support the demands for PtdIns(3,5)P(2)/PtdIns5P synthesis during life. phosphatidylinositol 5-phosphate 234-242 phosphoinositide kinase, FYVE type zinc finger containing Mus musculus 30-37 21349843-10 2011 The nonlinear decrease of the PIKfyve protein versus PIKfyve lipid products, the potential mechanism(s) discussed herein, may explain how one functional allele in PIKfyve(WT/KO) mice is able to support the demands for PtdIns(3,5)P(2)/PtdIns5P synthesis during life. phosphatidylinositol 5-phosphate 234-242 phosphoinositide kinase, FYVE type zinc finger containing Mus musculus 53-60 21349843-10 2011 The nonlinear decrease of the PIKfyve protein versus PIKfyve lipid products, the potential mechanism(s) discussed herein, may explain how one functional allele in PIKfyve(WT/KO) mice is able to support the demands for PtdIns(3,5)P(2)/PtdIns5P synthesis during life. phosphatidylinositol 5-phosphate 234-242 phosphoinositide kinase, FYVE type zinc finger containing Mus musculus 53-60 20967218-4 2010 Microarray analysis has identified a target gene (WRKY70) that is regulated by both ATX1 and by the exogenous addition of PtdIns5P in Arabidopsis. phosphatidylinositol 5-phosphate 122-130 WRKY DNA-binding protein 70 Arabidopsis thaliana 50-56 20967218-4 2010 Microarray analysis has identified a target gene (WRKY70) that is regulated by both ATX1 and by the exogenous addition of PtdIns5P in Arabidopsis. phosphatidylinositol 5-phosphate 122-130 homolog of anti-oxidant 1 Arabidopsis thaliana 84-88 20967218-5 2010 Interestingly, ATX1 contains a PtdIns5P interaction domain (PHD finger) and thus, phosphoinositide signaling, may link environmental stress to changes in gene transcription. phosphatidylinositol 5-phosphate 31-39 homolog of anti-oxidant 1 Arabidopsis thaliana 15-19 20967218-6 2010 PRINCIPAL FINDINGS: Using the plant Arabidopsis as a model system, we demonstrate a link between PtdIns5P and the activity of the chromatin modifier ATX1 in response to dehydration stress. phosphatidylinositol 5-phosphate 97-105 homolog of anti-oxidant 1 Arabidopsis thaliana 149-153 20967218-8 2010 The Arabidopsis homolog of myotubularin (AtMTM1) is capable of generating PtdIns5P and here, we show that AtMTM1 is essential for the induced increase in PtdIns5P upon dehydration. phosphatidylinositol 5-phosphate 74-82 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 41-47 20967218-8 2010 The Arabidopsis homolog of myotubularin (AtMTM1) is capable of generating PtdIns5P and here, we show that AtMTM1 is essential for the induced increase in PtdIns5P upon dehydration. phosphatidylinositol 5-phosphate 74-82 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 106-112 20967218-8 2010 The Arabidopsis homolog of myotubularin (AtMTM1) is capable of generating PtdIns5P and here, we show that AtMTM1 is essential for the induced increase in PtdIns5P upon dehydration. phosphatidylinositol 5-phosphate 154-162 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 41-47 20967218-8 2010 The Arabidopsis homolog of myotubularin (AtMTM1) is capable of generating PtdIns5P and here, we show that AtMTM1 is essential for the induced increase in PtdIns5P upon dehydration. phosphatidylinositol 5-phosphate 154-162 Myotubularin-like phosphatases II superfamily Arabidopsis thaliana 106-112 20967218-11 2010 We found that during dehydration stress, the physical presence of ATX1 at the WRKY70 locus was diminished and that ATX1 depletion resulted from it being retained in the cytoplasm when PtdIns5P was elevated. phosphatidylinositol 5-phosphate 184-192 homolog of anti-oxidant 1 Arabidopsis thaliana 115-119 20967218-13 2010 CONCLUSIONS/SIGNIFICANCE: The novelty of the manuscript is in the discovery of a mechanistic link between a chromatin modifying activity (ATX1) and a lipid (PtdIns5P) synthesis in a signaling pathway that ultimately results in altered expression of ATX1 dependent genes downregulated in response to dehydration stress. phosphatidylinositol 5-phosphate 157-165 homolog of anti-oxidant 1 Arabidopsis thaliana 138-142 20967218-13 2010 CONCLUSIONS/SIGNIFICANCE: The novelty of the manuscript is in the discovery of a mechanistic link between a chromatin modifying activity (ATX1) and a lipid (PtdIns5P) synthesis in a signaling pathway that ultimately results in altered expression of ATX1 dependent genes downregulated in response to dehydration stress. phosphatidylinositol 5-phosphate 157-165 homolog of anti-oxidant 1 Arabidopsis thaliana 249-253 17940011-1 2007 A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. phosphatidylinositol 5-phosphate 58-90 tumor protein p53 Homo sapiens 165-168 20417634-3 2010 Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. phosphatidylinositol 5-phosphate 20-28 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 134-137 19299694-0 2009 Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. phosphatidylinositol 5-phosphate 65-97 docking protein 1 Homo sapiens 14-19 19299694-0 2009 Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. phosphatidylinositol 5-phosphate 65-97 docking protein 2 Homo sapiens 24-29 19299694-5 2009 We find that Dok-1/Dok-2 PH domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 88-120 docking protein 1 Homo sapiens 13-18 19299694-5 2009 We find that Dok-1/Dok-2 PH domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 88-120 docking protein 2 Homo sapiens 19-24 19299694-5 2009 We find that Dok-1/Dok-2 PH domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 122-130 docking protein 1 Homo sapiens 13-18 19299694-5 2009 We find that Dok-1/Dok-2 PH domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 122-130 docking protein 2 Homo sapiens 19-24 18218622-0 2008 Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. phosphatidylinositol 5-phosphate 86-118 cullin 3 Homo sapiens 55-59 18218622-0 2008 Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. phosphatidylinositol 5-phosphate 86-118 speckle type BTB/POZ protein Homo sapiens 60-64 18218622-8 2008 The kinase-dead PIPKIIbeta mutant increases the cellular content of its substrate lipid phosphatidylinositol 5-phosphate (PI5P), suggesting that PI5P may stimulate Cul3-SPOP activity through a p38-dependent signaling pathway. phosphatidylinositol 5-phosphate 88-120 cullin 3 Homo sapiens 164-168 18218622-8 2008 The kinase-dead PIPKIIbeta mutant increases the cellular content of its substrate lipid phosphatidylinositol 5-phosphate (PI5P), suggesting that PI5P may stimulate Cul3-SPOP activity through a p38-dependent signaling pathway. phosphatidylinositol 5-phosphate 88-120 mitogen-activated protein kinase 14 Homo sapiens 193-196 18218622-9 2008 Expression of phosphatidylinositol-4,5-bisphosphate 4-phosphatases that generate PI5P dramatically stimulated Cul3-SPOP activity and was blocked by the p38 inhibitor SB203580. phosphatidylinositol 5-phosphate 81-85 cullin 3 Homo sapiens 110-114 18218622-9 2008 Expression of phosphatidylinositol-4,5-bisphosphate 4-phosphatases that generate PI5P dramatically stimulated Cul3-SPOP activity and was blocked by the p38 inhibitor SB203580. phosphatidylinositol 5-phosphate 81-85 speckle type BTB/POZ protein Homo sapiens 115-119 18218622-9 2008 Expression of phosphatidylinositol-4,5-bisphosphate 4-phosphatases that generate PI5P dramatically stimulated Cul3-SPOP activity and was blocked by the p38 inhibitor SB203580. phosphatidylinositol 5-phosphate 81-85 mitogen-activated protein kinase 14 Homo sapiens 152-155 20583997-1 2010 The beta-isoform of PIP4K (PtdIns5P-4-kinase) regulates the levels of nuclear PtdIns5P, which in turn modulates the acetylation of the tumour suppressor p53. phosphatidylinositol 5-phosphate 27-35 tumor protein p53 Homo sapiens 153-156 19442114-6 2009 Finally, we will discuss the relevance of the association between one ING protein (ING2) and the nuclear phosphoinositide, phosphatidylinositol-5-phosphate (PtdIns(5)P). phosphatidylinositol 5-phosphate 123-155 inhibitor of growth family member 2 Homo sapiens 83-87 19442114-6 2009 Finally, we will discuss the relevance of the association between one ING protein (ING2) and the nuclear phosphoinositide, phosphatidylinositol-5-phosphate (PtdIns(5)P). phosphatidylinositol 5-phosphate 157-167 inhibitor of growth family member 2 Homo sapiens 83-87 19442114-8 2009 The level of nuclear PtdIns(5)P sharply increases upon genotoxic stress, and this increase positively regulates ING2-mediated responses. phosphatidylinositol 5-phosphate 21-31 inhibitor of growth family member 2 Homo sapiens 112-116 18364242-3 2008 Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. phosphatidylinositol 5-phosphate 88-96 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Homo sapiens 152-159 17940011-1 2007 A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. phosphatidylinositol 5-phosphate 92-102 tumor protein p53 Homo sapiens 165-168 17940011-8 2007 This enzyme therefore controls nuclear levels of PtdIns-5-P and thereby p53-dependent apoptosis. phosphatidylinositol 5-phosphate 49-59 tumor protein p53 Homo sapiens 72-75 17663722-3 2007 The PX domain of PX-RICS interacted specifically with phosphatidylinositol 3-phosphate [PtdIns(3)P], PtdIns(4)P and PtdIns(5)P. phosphatidylinositol 5-phosphate 116-126 Rho GTPase activating protein 32 Mus musculus 17-24 16949365-1 2006 Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 212-244 inhibitor of growth family member 2 Homo sapiens 0-29 17469822-0 2007 Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. phosphatidylinositol 5-phosphate 11-43 inhibitor of growth family member 2 Homo sapiens 89-93 17469822-1 2007 The interaction of PtdIns(5)P with the tumor suppressor protein ING2 has been implicated in the regulation of chromatin modification. phosphatidylinositol 5-phosphate 19-29 inhibitor of growth family member 2 Homo sapiens 64-68 16949365-1 2006 Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 212-244 inhibitor of growth family member 2 Homo sapiens 31-35 16949365-1 2006 Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 246-254 inhibitor of growth family member 2 Homo sapiens 0-29 16949365-1 2006 Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). phosphatidylinositol 5-phosphate 246-254 inhibitor of growth family member 2 Homo sapiens 31-35 16949365-5 2006 Finally, we show that changes in nuclear PtdIns5P are translated into changes in the association of ING2 with chromatin. phosphatidylinositol 5-phosphate 41-49 inhibitor of growth family member 2 Homo sapiens 100-104 16585509-0 2006 The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. phosphatidylinositol 5-phosphate 50-82 homolog of anti-oxidant 1 Arabidopsis thaliana 38-42 16585509-2 2006 Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. phosphatidylinositol 5-phosphate 106-138 homolog of anti-oxidant 1 Arabidopsis thaliana 43-47 16585509-2 2006 Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. phosphatidylinositol 5-phosphate 106-138 homolog of anti-oxidant 1 Arabidopsis thaliana 64-68 15909982-5 2005 In addition, we have performed in vitro binding studies that demonstrate that the PH domains of Tfb1 and p62 specifically bind to monophosphorylated inositides [PtdIns(5)P and PtdIns(3)P]. phosphatidylinositol 5-phosphate 161-171 general transcription factor IIH subunit 1 Homo sapiens 96-100 16244667-5 2005 Netrin-1 stimulates PlTPalpha binding to DCC and to phosphatidylinositol (5) phosphate [Pl(5)P], increases its lipid-transfer activity and elevates hydrolysis of phosphatidylinositol bisphosphate (PlP2). phosphatidylinositol 5-phosphate 52-86 netrin 1 Mus musculus 0-8 15909982-5 2005 In addition, we have performed in vitro binding studies that demonstrate that the PH domains of Tfb1 and p62 specifically bind to monophosphorylated inositides [PtdIns(5)P and PtdIns(3)P]. phosphatidylinositol 5-phosphate 161-171 general transcription factor IIH subunit 1 Homo sapiens 105-108 15909982-6 2005 NMR chemical shift mapping demonstrated that the PtdIns(5)P binding site on Tfb1 (p62) is located in the basic pocket formed by beta-strands beta5-beta7 of the PH domain fold. phosphatidylinositol 5-phosphate 49-59 general transcription factor IIH subunit 1 Homo sapiens 76-80 15909982-6 2005 NMR chemical shift mapping demonstrated that the PtdIns(5)P binding site on Tfb1 (p62) is located in the basic pocket formed by beta-strands beta5-beta7 of the PH domain fold. phosphatidylinositol 5-phosphate 49-59 general transcription factor IIH subunit 1 Homo sapiens 82-85 15909982-9 2005 NMR chemical shift mapping demonstrated that the VP16 binding site within the PH domain of Tfb1 (p62) overlaps with the PtdIns(5)P binding site on Tfb1 (p62). phosphatidylinositol 5-phosphate 120-130 host cell factor C1 Homo sapiens 49-53 15909982-9 2005 NMR chemical shift mapping demonstrated that the VP16 binding site within the PH domain of Tfb1 (p62) overlaps with the PtdIns(5)P binding site on Tfb1 (p62). phosphatidylinositol 5-phosphate 120-130 general transcription factor IIH subunit 1 Homo sapiens 91-95 15909982-9 2005 NMR chemical shift mapping demonstrated that the VP16 binding site within the PH domain of Tfb1 (p62) overlaps with the PtdIns(5)P binding site on Tfb1 (p62). phosphatidylinositol 5-phosphate 120-130 general transcription factor IIH subunit 1 Homo sapiens 97-100 15909982-9 2005 NMR chemical shift mapping demonstrated that the VP16 binding site within the PH domain of Tfb1 (p62) overlaps with the PtdIns(5)P binding site on Tfb1 (p62). phosphatidylinositol 5-phosphate 120-130 general transcription factor IIH subunit 1 Homo sapiens 147-151 15909982-9 2005 NMR chemical shift mapping demonstrated that the VP16 binding site within the PH domain of Tfb1 (p62) overlaps with the PtdIns(5)P binding site on Tfb1 (p62). phosphatidylinositol 5-phosphate 120-130 general transcription factor IIH subunit 1 Homo sapiens 153-156 15475361-4 2004 The PLD1 PX domain was found to have high phosphoinositide specificity, i.e. phosphatidylinositol 3,4,5-trisphosphate (PtdIns-(3,4,5)P(3)) >> phosphatidylinositol 3-phosphate > phosphatidylinositol 5-phosphate >> other phosphoinositides. phosphatidylinositol 5-phosphate 186-218 phospholipase D1 Homo sapiens 4-8 15840652-6 2005 Consequently, generation of PtdIns5P at the plasma membrane by ectopic expression of the bacterial phosphatase IpgD leads to a translocation of MTMR3 that requires the PH-G domain. phosphatidylinositol 5-phosphate 28-36 myotubularin related protein 3 Homo sapiens 144-149 16473631-2 2005 p40 was recently identified as an associated protein of the PtdIns 5-P/PtdIns 3,5-P2-producing kinase PIKFyve. phosphatidylinositol 5-phosphate 60-70 interleukin 9 Homo sapiens 0-3 16473631-3 2005 Moreover, p40 recovery in membrane fractions appeared totally dependent on the presence of an intact enzymatic activity of PIKFyve, implying a mechanism of p40 membrane association dependent on membrane PtdIns 5-P and/or PtdIns 3,5-P2. phosphatidylinositol 5-phosphate 203-213 interleukin 9 Homo sapiens 10-13 16473631-3 2005 Moreover, p40 recovery in membrane fractions appeared totally dependent on the presence of an intact enzymatic activity of PIKFyve, implying a mechanism of p40 membrane association dependent on membrane PtdIns 5-P and/or PtdIns 3,5-P2. phosphatidylinositol 5-phosphate 203-213 interleukin 9 Homo sapiens 156-159 16473631-4 2005 Here we have evaluated plausible interaction of recombinant p40 with the PIKFyve products PtdIns 5-P and PtdIns 3,5-P2 by a synthetic-liposome binding assay. phosphatidylinositol 5-phosphate 90-100 interleukin 9 Homo sapiens 60-63 15284192-0 2004 Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation. phosphatidylinositol 5-phosphate 41-73 insulin Cricetulus griseus 78-85 15284192-2 2004 Here we have examined a plausible role of PtdIns 5-P as a signaling intermediate in acute insulin action. phosphatidylinositol 5-phosphate 42-52 insulin Cricetulus griseus 90-97 15284192-4 2004 Similarly to insulin, found to induce a rapid disassembly of Texas-Red phalloidin-labeled actin stress fibers in CHO-T cells, microinjected PtdIns 5-P, but not other PIs, decreased the number and length of F-actin stress fibers in this cell type to a magnitude seen in response to insulin. phosphatidylinositol 5-phosphate 140-150 insulin Cricetulus griseus 13-20 15284192-4 2004 Similarly to insulin, found to induce a rapid disassembly of Texas-Red phalloidin-labeled actin stress fibers in CHO-T cells, microinjected PtdIns 5-P, but not other PIs, decreased the number and length of F-actin stress fibers in this cell type to a magnitude seen in response to insulin. phosphatidylinositol 5-phosphate 140-150 insulin Cricetulus griseus 281-288 15284192-6 2004 As with insulin, the PtdIns 5-P-induced loss of actin stress fibers was independent of PI 3-kinase activation. phosphatidylinositol 5-phosphate 21-31 insulin Cricetulus griseus 8-15 15284192-7 2004 Furthermore, sequestration of functional PtdIns 5-P, either by ectopic expression of 3xPHD domains that bind selectively PtdIns 5-P or by microinjecting the GST-3xPHD fusion peptide, abrogated insulin-induced F-actin stress fiber disassembly in CHO-T cells. phosphatidylinositol 5-phosphate 41-51 insulin Cricetulus griseus 193-200 15284192-8 2004 In 3T3-L1 adipocytes, microinjected PtdIns 5-P, but not other PIs, partially mimicked insulin"s effect of translocating enhanced green fluorescent protein-GLUT4 to the cell surface. phosphatidylinositol 5-phosphate 36-46 insulin Cricetulus griseus 86-93 15284192-10 2004 Involvement of PIKfyve membrane recruitment, but not activation, and/or a decrease in PtdIns 4,5-bisphosphate levels are likely to be among the mechanisms underlying the insulin-induced PtdIns 5-P increase. phosphatidylinositol 5-phosphate 186-196 insulin Cricetulus griseus 170-177 15284192-11 2004 Together, these results identify PtdIns 5-P as a novel key intermediate for insulin signaling in F-actin remodeling and GLUT4 translocation. phosphatidylinositol 5-phosphate 33-43 insulin Cricetulus griseus 76-83 15247229-1 2004 We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro. phosphatidylinositol 5-phosphate 83-115 Protein tyrosine phosphatase, mitochondrial 1 Drosophila melanogaster 21-42 15247229-1 2004 We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro. phosphatidylinositol 5-phosphate 83-115 Protein tyrosine phosphatase, mitochondrial 1 Drosophila melanogaster 44-48 15247229-1 2004 We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro. phosphatidylinositol 5-phosphate 117-123 Protein tyrosine phosphatase, mitochondrial 1 Drosophila melanogaster 21-42 15247229-1 2004 We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro. phosphatidylinositol 5-phosphate 117-123 Protein tyrosine phosphatase, mitochondrial 1 Drosophila melanogaster 44-48 14660569-0 2004 Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells. phosphatidylinositol 5-phosphate 14-46 myotubularin 1 Homo sapiens 85-97 14660569-7 2004 In L6 myotubes overexpressing MTM1, hyperosmotic shock induced an increase in the mass level of PtdIns(5)P that was reduced by 50% upon overexpression of the MTM1 inactive mutant D278A. phosphatidylinositol 5-phosphate 96-106 myotubularin 1 Homo sapiens 30-34 14660569-7 2004 In L6 myotubes overexpressing MTM1, hyperosmotic shock induced an increase in the mass level of PtdIns(5)P that was reduced by 50% upon overexpression of the MTM1 inactive mutant D278A. phosphatidylinositol 5-phosphate 96-106 myotubularin 1 Homo sapiens 158-162 14660569-8 2004 These data demonstrate for the first time a role for MTM1 in the production of PtdIns(5)P in mammalian cells, suggesting that the lack of transformation of phosphatidylinositol 3,5-bisphosphate into PtdIns(5)P might be an important component in the etiology of myotubular myopathy. phosphatidylinositol 5-phosphate 79-89 myotubularin 1 Homo sapiens 53-57 12646134-0 2003 Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. phosphatidylinositol 5-phosphate 0-32 myotubularin 1 Homo sapiens 87-99 12859901-5 2003 We find that the PHD fingers of ING2 and other diverse nuclear proteins bind in vitro to PtdInsPs, including the rare PtdInsP species, phosphatidylinositol 5-phosphate (PtdIns(5)P). phosphatidylinositol 5-phosphate 135-167 inhibitor of growth family member 2 Homo sapiens 32-36 12859901-5 2003 We find that the PHD fingers of ING2 and other diverse nuclear proteins bind in vitro to PtdInsPs, including the rare PtdInsP species, phosphatidylinositol 5-phosphate (PtdIns(5)P). phosphatidylinositol 5-phosphate 169-179 inhibitor of growth family member 2 Homo sapiens 32-36 12859901-6 2003 Further, we demonstrate that the ING2 PHD finger interacts with PtdIns(5)P in vivo and provide evidence that this interaction regulates the ability of ING2 to activate p53 and p53-dependent apoptotic pathways. phosphatidylinositol 5-phosphate 64-74 inhibitor of growth family member 2 Homo sapiens 33-37 12859901-6 2003 Further, we demonstrate that the ING2 PHD finger interacts with PtdIns(5)P in vivo and provide evidence that this interaction regulates the ability of ING2 to activate p53 and p53-dependent apoptotic pathways. phosphatidylinositol 5-phosphate 64-74 inhibitor of growth family member 2 Homo sapiens 151-155 12859901-6 2003 Further, we demonstrate that the ING2 PHD finger interacts with PtdIns(5)P in vivo and provide evidence that this interaction regulates the ability of ING2 to activate p53 and p53-dependent apoptotic pathways. phosphatidylinositol 5-phosphate 64-74 tumor protein p53 Homo sapiens 168-171 12859901-6 2003 Further, we demonstrate that the ING2 PHD finger interacts with PtdIns(5)P in vivo and provide evidence that this interaction regulates the ability of ING2 to activate p53 and p53-dependent apoptotic pathways. phosphatidylinositol 5-phosphate 64-74 tumor protein p53 Homo sapiens 176-179 12878591-6 2003 In contrast to previously characterized phosphoinositide phosphatases, PLIP has a preference for phosphatidylinositol 5-phosphate, a newly discovered phosphoinositide. phosphatidylinositol 5-phosphate 97-129 protein tyrosine phosphatase mitochondrial 1 Homo sapiens 71-75 12646134-5 2003 The product of PtdIns(3,5)P2 hydrolysis, PtdIns5P, causes MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of MTM1, MTMR3, and MTMR6. phosphatidylinositol 5-phosphate 41-49 myotubularin 1 Homo sapiens 58-62 12646134-5 2003 The product of PtdIns(3,5)P2 hydrolysis, PtdIns5P, causes MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of MTM1, MTMR3, and MTMR6. phosphatidylinositol 5-phosphate 41-49 myotubularin 1 Homo sapiens 163-167 12646134-5 2003 The product of PtdIns(3,5)P2 hydrolysis, PtdIns5P, causes MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of MTM1, MTMR3, and MTMR6. phosphatidylinositol 5-phosphate 41-49 myotubularin related protein 3 Homo sapiens 169-174 10854858-0 2000 Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay. phosphatidylinositol 5-phosphate 56-88 coagulation factor II, thrombin Homo sapiens 0-8 12646134-5 2003 The product of PtdIns(3,5)P2 hydrolysis, PtdIns5P, causes MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of MTM1, MTMR3, and MTMR6. phosphatidylinositol 5-phosphate 41-49 myotubularin related protein 6 Homo sapiens 180-185 12646134-7 2003 We propose that the myotubularin family of enzymes utilize both PtdIns3P and PtdIns(3,5)P2 as substrates, and that PtdIns5P functions in a positive feedback loop controlling their activity. phosphatidylinositol 5-phosphate 115-123 myotubularin 1 Homo sapiens 20-32 10854858-5 2000 This assay was used on platelets to show that during 10 min stimulation with thrombin, the mass level of PtdIns5P increases, implying the existence of an agonist-stimulated synthetic mechanism. phosphatidylinositol 5-phosphate 105-113 coagulation factor II, thrombin Homo sapiens 77-85 34369843-0 2021 An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation. phosphatidylinositol 5-phosphate 40-48 unc-51 like autophagy activating kinase 1 Homo sapiens 8-12 34699202-1 2021 PIP4K2A is an insufficiently studied type II lipid kinase that catalyzes the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI4,5P2). phosphatidylinositol 5-phosphate 91-123 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Homo sapiens 0-7 34699202-1 2021 PIP4K2A is an insufficiently studied type II lipid kinase that catalyzes the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI4,5P2). phosphatidylinositol 5-phosphate 125-129 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Homo sapiens 0-7 34369843-0 2021 An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation. phosphatidylinositol 5-phosphate 40-48 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 3-7 34382905-0 2021 AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. phosphatidylinositol 5-phosphate 65-73 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 34382905-0 2021 AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. phosphatidylinositol 5-phosphate 65-73 unc-51 like autophagy activating kinase 1 Homo sapiens 15-19 34382905-0 2021 AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. phosphatidylinositol 5-phosphate 65-73 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 35-42 34382905-2 2021 Recently, we described a non-canonical signaling pathway involving the kinases AMPK, ULK1 and PIKFYVE that are induced during glucose starvation, leading to the formation of PtdIns5P-containing autophagosomes, resulting in increased autophagy flux and clearance of autophagy substrates. phosphatidylinositol 5-phosphate 174-182 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 79-83 34382905-2 2021 Recently, we described a non-canonical signaling pathway involving the kinases AMPK, ULK1 and PIKFYVE that are induced during glucose starvation, leading to the formation of PtdIns5P-containing autophagosomes, resulting in increased autophagy flux and clearance of autophagy substrates. phosphatidylinositol 5-phosphate 174-182 unc-51 like autophagy activating kinase 1 Homo sapiens 85-89 34382905-2 2021 Recently, we described a non-canonical signaling pathway involving the kinases AMPK, ULK1 and PIKFYVE that are induced during glucose starvation, leading to the formation of PtdIns5P-containing autophagosomes, resulting in increased autophagy flux and clearance of autophagy substrates. phosphatidylinositol 5-phosphate 174-182 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 94-101 34382905-4 2021 ULK1 then phosphorylates PIKFYVE at S1548, leading to its activation and increased PtdIns5P formation, which enables the recruitment of machinery required for autophagosome biogenesis. phosphatidylinositol 5-phosphate 83-91 unc-51 like autophagy activating kinase 1 Homo sapiens 0-4 34382905-4 2021 ULK1 then phosphorylates PIKFYVE at S1548, leading to its activation and increased PtdIns5P formation, which enables the recruitment of machinery required for autophagosome biogenesis. phosphatidylinositol 5-phosphate 83-91 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 25-32 34369843-0 2021 An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation. phosphatidylinositol 5-phosphate 40-48 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 13-20 34369843-4 2021 The activated PIKFYVE consequently enhances the formation of phosphatidylinositol-5-phosphate (PtdIns5P)-containing autophagosomes, and therefore drives autophagy upregulation. phosphatidylinositol 5-phosphate 61-93 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 14-21 34369843-4 2021 The activated PIKFYVE consequently enhances the formation of phosphatidylinositol-5-phosphate (PtdIns5P)-containing autophagosomes, and therefore drives autophagy upregulation. phosphatidylinositol 5-phosphate 95-103 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 14-21 34369843-5 2021 The novel discovery of how ULK1 regulates the non-canonical autophagy signaling (PtdIns5P-dependent autophagy), not only expands our knowledge of autophagy, but also sheds light on therapeutic strategies for curing human disorders, where glucose-induced starvation can play an important role. phosphatidylinositol 5-phosphate 81-89 unc-51 like autophagy activating kinase 1 Homo sapiens 27-31 34312224-3 2021 PIP4K2A, 2B, and 2C constitute a family of lipid kinases that phosphorylate PtdIns5P to PtdIns(4,5)P 2 They are involved in stress signaling, act as synthetic lethal targets in p53-null tumors, and in mice, the loss of PIP4K2C leads to late onset hyperinflammation. phosphatidylinositol 5-phosphate 76-84 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Mus musculus 0-11 34312224-3 2021 PIP4K2A, 2B, and 2C constitute a family of lipid kinases that phosphorylate PtdIns5P to PtdIns(4,5)P 2 They are involved in stress signaling, act as synthetic lethal targets in p53-null tumors, and in mice, the loss of PIP4K2C leads to late onset hyperinflammation. phosphatidylinositol 5-phosphate 76-84 transformation related protein 53, pseudogene Mus musculus 177-180 34312224-3 2021 PIP4K2A, 2B, and 2C constitute a family of lipid kinases that phosphorylate PtdIns5P to PtdIns(4,5)P 2 They are involved in stress signaling, act as synthetic lethal targets in p53-null tumors, and in mice, the loss of PIP4K2C leads to late onset hyperinflammation. phosphatidylinositol 5-phosphate 76-84 phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Mus musculus 219-226 35573204-7 2022 PtdIns5P which binds septin 9 and MTMR3 which converts PtdIns(3,5)P2 into PtdIns(5) recapitulates the effects of septin 9. phosphatidylinositol 5-phosphate 0-8 septin 9 Homo sapiens 21-29 35080463-3 2022 Here, we show that apoptotic body like liposomes loaded with phosphatidylinositol 5-phosphate (ABL/PI5P) enhance the antimycobacterial response, both in macrophages from healthy donors exposed to pharmacological inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and in macrophages from CF patients, by enhancing phagosome acidification and reactive oxygen species (ROS) production. phosphatidylinositol 5-phosphate 61-93 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 95-103 35080463-3 2022 Here, we show that apoptotic body like liposomes loaded with phosphatidylinositol 5-phosphate (ABL/PI5P) enhance the antimycobacterial response, both in macrophages from healthy donors exposed to pharmacological inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and in macrophages from CF patients, by enhancing phagosome acidification and reactive oxygen species (ROS) production. phosphatidylinositol 5-phosphate 61-93 CF transmembrane conductance regulator Homo sapiens 226-277 35080463-3 2022 Here, we show that apoptotic body like liposomes loaded with phosphatidylinositol 5-phosphate (ABL/PI5P) enhance the antimycobacterial response, both in macrophages from healthy donors exposed to pharmacological inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and in macrophages from CF patients, by enhancing phagosome acidification and reactive oxygen species (ROS) production. phosphatidylinositol 5-phosphate 61-93 CF transmembrane conductance regulator Homo sapiens 279-283 35237274-4 2022 In this study, we have evaluated, in an in vitro model of human macrophages, the efficacy of a combined treatment consisting of apoptotic body-like liposomes loaded with phosphatidylinositol 5-phosphate (ABL/PI5P) and phiBO1E, a lytic phage specific for the major high-risk clone of KPC-positive MDR-KP. phosphatidylinositol 5-phosphate 170-202 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 204-212