PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26073575-0 2015 Nickel-Catalyzed C-O/C-H Cross-Coupling Reactions for C-C Bond Formation. Nickel 0-6 cochlin Homo sapiens 17-24 25979628-0 2015 Dysfunction of methionine sulfoxide reductases to repair damaged proteins by nickel nanoparticles. Nickel 77-83 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 15-46 25877470-8 2015 When co-expressed in R1-11 cells, haemagglutinin-tagged glycine-to-leucine mutants and His10-tagged wild-type (WT) hPCFT co-associated on nickel affinity columns, suggesting that the GXXXG motifs are not directly involved in hPCFT oligomerization. Nickel 138-144 solute carrier family 46 member 1 Homo sapiens 115-120 25659946-3 2015 However, biocompatibility of nickel-titanium (Ni-Ti) alloy, which is the only practical SMA at present, has been questioned because of its high nickel content. Nickel 29-35 immunoglobulin mu binding protein 2 Mus musculus 88-91 26877743-0 2015 Ultrasonic Technique to Retrieve a Rotary Nickel-Titanium File Broken Beyond the Apex and a Stainless Steel File from the Root Canal of a Mandibular Molar: A Case Report. Nickel 42-48 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 81-85 25924210-7 2015 Nickel, a competitive inhibitor of ZIP1, and ZIP1 knock-down decreased zinc uptake by both types of cells. Nickel 0-6 solute carrier family 39 (zinc transporter), member 1 Mus musculus 35-39 25760691-3 2015 HER2/CD3 BsAb was expressed in Chinese hamster ovary cells and purified via nickel column chromatography. Nickel 76-82 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-4 25782739-6 2015 The TPM domain containing region of Rv2345 was cloned and expressed using pET28a vector in Escherichia coli and purified by Nickel affinity chromatography. Nickel 124-130 transmembrane protein Mycobacterium tuberculosis H37Rv 36-42 25827072-6 2015 Expression of FBXO11 is downregulated by EMT-inducing signals TGFbeta and nickel. Nickel 74-80 F-box protein 11 Homo sapiens 14-20 25771289-5 2015 The most efficient (IIP1, around 12 mg g(-1) of nickel) was then positively checked for Ni(II) retention in presence of some competing species over a wide range of concentration. Nickel 48-54 GIPC PDZ domain containing family member 1 Homo sapiens 20-24 25946374-2 2015 We find indications for up to 100% spin-polarized currents across nickel oxide atomic junctions formed between two nickel electrodes. Nickel 66-72 spindlin 1 Homo sapiens 35-39 25875803-2 2015 The nickel disks, with radius 17 mum and thickness 300 nm, displayed varied transport behavior that depended on the size of the pitch and the orientation of the gravitational force with respect to the cholesteric axis. Nickel 4-10 latexin Homo sapiens 33-36 26019370-3 2015 The Manalpha1-2 saccharide moieties were assembled using a nickel catalyst, Ni(4-F-PhCN)4(OTf)2, to activate trihaloacetimidate donors under mild and operationally simple procedure. Nickel 59-65 POU class 2 homeobox 2 Homo sapiens 90-95 26104335-2 2015 Regarding the relation of PrP to heavy metals it is known that PrP is able to bind divalent ions of copper, zinc, manganese and nickel through its octarepeat region. Nickel 128-134 prion protein Homo sapiens 26-29 26104335-2 2015 Regarding the relation of PrP to heavy metals it is known that PrP is able to bind divalent ions of copper, zinc, manganese and nickel through its octarepeat region. Nickel 128-134 prion protein Homo sapiens 63-66 25846142-5 2015 Strikingly, the nickel porphyrin derivative was able to displace hPOT1 shelterin protein from telomeres in human cells. Nickel 16-22 protection of telomeres 1 Homo sapiens 65-70 26025404-5 2015 The nickel chelating resin was used to purify the protein in size exclusion chromatography (SEC) and the results indicated that AtSEP3 protein was present in the form of tetramer. Nickel 4-10 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 128-134 26436117-2 2015 Truncated VP7 protein purified by nickel affinity column was lyophilized in the presence of trehalose and mannitol at 60 mM final concentration and then exposed to different temperature like 4, 25, 37 and 45 C for various periods like 5 months, 7 weeks, 7 days and 48 h, respectively. Nickel 34-40 VP7 Bluetongue virus 10-13 25704435-1 2015 For the selective removal of arsenate (As(V)) a hybrid sorbent was prepared using a non-toxic natural organic material, chitosan, by loading a transition metal, nickel. Nickel 161-167 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 39-44 25864375-3 2015 The combined analysis of XRD, SEM, EDS, XPS, TGA and Raman results together confirm that the growth of nickel catalyst is completely reversible in redox cycles. Nickel 103-109 T-box transcription factor 1 Homo sapiens 45-48 25673294-1 2015 DCs are the first immune cells to be exposed to allergens, including chemical sensitizers, such as nickel, a human TLR4 agonist that induces DC maturation. Nickel 99-105 toll like receptor 4 Homo sapiens 115-119 25840981-4 2015 METHODS: rh-HGF was expressed in human embryonic kidney 293 cells and purified by nickel-nitrilotriacetic acid affinity chromatography. Nickel 82-88 hepatocyte growth factor Homo sapiens 12-15 25589393-3 2015 A number of novel polymer complexes of various anions of copper(II), cobalt(II), nickel(II) and uranyl(II) with N(4-(acrylamido)-2-hydroxy benzoic acid) (ABH) have been synthesized and characterized by elemental analysis, IR, 1H NMR, magnetic susceptibility measurements, electronic spin resonance, vibrational spectra and thermal analysis. Nickel 81-87 alkB homolog 1, histone H2A dioxygenase Homo sapiens 154-157 25745085-8 2015 Therapeutic application of (131)I in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved overall survival. Nickel 44-47 chemokine (C-C motif) ligand 5 Mus musculus 37-43 25579632-0 2015 Ni(ii) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency. Nickel 88-94 serpin family A member 1 Homo sapiens 40-59 25620052-2 2015 Biosynthesis of all Hyd involves the insertion of a Fe(CN)2CO group and a subsequent insertion of nickel ions through the HypA/HybF, HypB and SlyD proteins. Nickel 98-104 hypA Escherichia coli 122-126 25628016-0 2015 Response of CnrX from Cupriavidus metallidurans CH34 to nickel binding. Nickel 56-62 periplasmic nickel sensor Cupriavidus metallidurans CH34 12-16 25628016-5 2015 CnrH availability leads to transcription initiation at the promoters cnrYp and cnrCp and to the expression of the genes in the cnrYXHCBA nickel resistance determinant. Nickel 137-143 RNA polymerase sigma factor cnrH Cupriavidus metallidurans CH34 0-4 25628016-7 2015 To study the nickel-mediated triggering process by CnrX, we have altered selected residues, F66, M123, and Y135, and explored the physiological consequences of these changes with respect to metal resistance, expression of a cnrCBA-lacZ reporter fusion and protein production. Nickel 13-19 periplasmic nickel sensor Cupriavidus metallidurans CH34 51-55 25663129-3 2015 Emission quenching and flash photolysis studies reveal that this hybrid system allows for effective electron transfer from the excited CdS nanosheets to the nickel-based complex to generate reduced intermediate species for efficient hydrogen evolution. Nickel 157-163 CDP-diacylglycerol synthase 1 Homo sapiens 135-138 25931227-2 2015 METHODS: The fusion protein PET28a-NR4A1-DBD was constructed and purified with the nickel affinity chromatography, cation-exchange chromatography and gel filtration chromatography. Nickel 83-89 nuclear receptor subfamily 4 group A member 1 Homo sapiens 35-40 25716520-5 2015 In contrast to this the luminescence of photoexcited Ru2 on NiOx is efficiently quenched and the ultrafast transient absorption spectra reveal the formation of oxidized nickel centres overlaid by the absorption of the reduced dye Ru2 with a characteristic time-constant of 18 ps. Nickel 169-175 doublecortin domain containing 2 Homo sapiens 53-56 25803856-0 2015 MD-2 determinants of nickel and cobalt-mediated activation of human TLR4. Nickel 21-27 lymphocyte antigen 96 Homo sapiens 0-4 25803856-1 2015 Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. Nickel 83-89 toll like receptor 4 Homo sapiens 49-53 25803856-2 2015 This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. Nickel 46-52 toll like receptor 4 Homo sapiens 115-119 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 lymphocyte antigen 96 Homo sapiens 34-38 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 toll like receptor 4 Homo sapiens 69-73 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 lymphocyte antigen 96 Homo sapiens 74-78 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 toll like receptor 4 Homo sapiens 127-131 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 lymphocyte antigen 96 Homo sapiens 74-78 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 93-99 toll like receptor 4 Homo sapiens 127-131 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 lymphocyte antigen 96 Homo sapiens 34-38 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 toll like receptor 4 Homo sapiens 69-73 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 lymphocyte antigen 96 Homo sapiens 74-78 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 toll like receptor 4 Homo sapiens 127-131 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 lymphocyte antigen 96 Homo sapiens 74-78 25803856-3 2015 We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. Nickel 104-110 toll like receptor 4 Homo sapiens 127-131 25803856-4 2015 We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Nickel 148-154 lymphocyte antigen 96 Homo sapiens 14-18 25803856-4 2015 We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Nickel 148-154 toll like receptor 4 Homo sapiens 23-27 25803856-7 2015 We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Nickel 43-49 toll like receptor 4 Homo sapiens 35-39 25803856-7 2015 We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Nickel 43-49 MYD88 innate immune signal transduction adaptor Homo sapiens 87-92 25650559-0 2015 Nickel-catalyzed enantioselective C-C bond formation through C(sp2)-O cleavage in aryl esters. Nickel 0-6 Sp2 transcription factor Homo sapiens 61-66 25711163-1 2015 The nickel-catalyzed amination of aryl chlorides to form primary arylamines occurs with ammonia or ammonium sulfate and a well-defined single-component nickel(0) precatalyst containing a Josiphos ligand and an eta(2)-bound benzonitrile ligand. Nickel 4-10 endothelin receptor type A Homo sapiens 210-213 25711163-1 2015 The nickel-catalyzed amination of aryl chlorides to form primary arylamines occurs with ammonia or ammonium sulfate and a well-defined single-component nickel(0) precatalyst containing a Josiphos ligand and an eta(2)-bound benzonitrile ligand. Nickel 152-158 endothelin receptor type A Homo sapiens 210-213 25661824-1 2015 A nickel-catalyzed thiolation of unactivated C(sp(2))-H bonds with disulfides employing the PIP directing group was described. Nickel 2-8 prolactin induced protein Homo sapiens 92-95 25742007-0 2015 Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability. Nickel 0-6 interleukin 6 Mus musculus 59-72 25583101-8 2015 Stratification by allergen showed decreased expression of immune, TH1-subset, and TH2-subset genes in nickel-related AD responses, with increased TH17/IL-23 skewing. Nickel 102-108 negative elongation factor complex member C/D Homo sapiens 66-69 25661762-0 2015 I"ll bet you a nickel you don"t ask. Nickel 15-21 delta/notch like EGF repeat containing Homo sapiens 5-8 25789747-13 2015 These effects on p-FoxO3a and NIS could be decreased by the DN-Akt plasmid, enhanced by the CA-Akt plasmid, and blocked by FoxO3a siRNA. Nickel 30-33 AKT serine/threonine kinase 1 Rattus norvegicus 63-66 25789747-13 2015 These effects on p-FoxO3a and NIS could be decreased by the DN-Akt plasmid, enhanced by the CA-Akt plasmid, and blocked by FoxO3a siRNA. Nickel 30-33 AKT serine/threonine kinase 1 Rattus norvegicus 95-98 25789747-13 2015 These effects on p-FoxO3a and NIS could be decreased by the DN-Akt plasmid, enhanced by the CA-Akt plasmid, and blocked by FoxO3a siRNA. Nickel 30-33 forkhead box O3 Rattus norvegicus 123-129 25789747-14 2015 The overexpressed FoxO3a could reduce NIS promoter activity. Nickel 38-41 forkhead box O3 Rattus norvegicus 18-24 25789747-15 2015 Our results suggested that PCB118 induces thyroid cell dysfunction through the Akt/FoxO3a/NIS signaling pathway. Nickel 90-93 AKT serine/threonine kinase 1 Rattus norvegicus 79-82 25789747-15 2015 Our results suggested that PCB118 induces thyroid cell dysfunction through the Akt/FoxO3a/NIS signaling pathway. Nickel 90-93 forkhead box O3 Rattus norvegicus 83-89 25614230-4 2015 The continuous exposure of the differentiating NT2 cells to a not cytotoxic nickel concentration (10muM) increased the expression of specific neuronal differentiation markers such as neural cell adhesion molecule (NCAM) and microtubule associated protein 2 (MAP2). Nickel 76-82 neural cell adhesion molecule 1 Homo sapiens 183-212 25614230-4 2015 The continuous exposure of the differentiating NT2 cells to a not cytotoxic nickel concentration (10muM) increased the expression of specific neuronal differentiation markers such as neural cell adhesion molecule (NCAM) and microtubule associated protein 2 (MAP2). Nickel 76-82 neural cell adhesion molecule 1 Homo sapiens 214-218 25614230-4 2015 The continuous exposure of the differentiating NT2 cells to a not cytotoxic nickel concentration (10muM) increased the expression of specific neuronal differentiation markers such as neural cell adhesion molecule (NCAM) and microtubule associated protein 2 (MAP2). Nickel 76-82 microtubule associated protein 2 Homo sapiens 224-256 25614230-4 2015 The continuous exposure of the differentiating NT2 cells to a not cytotoxic nickel concentration (10muM) increased the expression of specific neuronal differentiation markers such as neural cell adhesion molecule (NCAM) and microtubule associated protein 2 (MAP2). Nickel 76-82 microtubule associated protein 2 Homo sapiens 258-262 25614230-5 2015 Furthermore, nickel exposure increased the expression of hypoxia-inducible-factor-1alpha (HIF-1alpha) and induced the activation of the AKT/PKB kinase pathway, as shown by the increase of P(Ser-9)-GSK-3beta, the inactive form of glycogen synthase kinase-3beta (GSK-3beta). Nickel 13-19 hypoxia inducible factor 1 subunit alpha Homo sapiens 57-88 25614230-5 2015 Furthermore, nickel exposure increased the expression of hypoxia-inducible-factor-1alpha (HIF-1alpha) and induced the activation of the AKT/PKB kinase pathway, as shown by the increase of P(Ser-9)-GSK-3beta, the inactive form of glycogen synthase kinase-3beta (GSK-3beta). Nickel 13-19 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-100 25614230-5 2015 Furthermore, nickel exposure increased the expression of hypoxia-inducible-factor-1alpha (HIF-1alpha) and induced the activation of the AKT/PKB kinase pathway, as shown by the increase of P(Ser-9)-GSK-3beta, the inactive form of glycogen synthase kinase-3beta (GSK-3beta). Nickel 13-19 glycogen synthase kinase 3 beta Homo sapiens 197-206 25614230-5 2015 Furthermore, nickel exposure increased the expression of hypoxia-inducible-factor-1alpha (HIF-1alpha) and induced the activation of the AKT/PKB kinase pathway, as shown by the increase of P(Ser-9)-GSK-3beta, the inactive form of glycogen synthase kinase-3beta (GSK-3beta). Nickel 13-19 glycogen synthase kinase 3 beta Homo sapiens 229-259 25614230-5 2015 Furthermore, nickel exposure increased the expression of hypoxia-inducible-factor-1alpha (HIF-1alpha) and induced the activation of the AKT/PKB kinase pathway, as shown by the increase of P(Ser-9)-GSK-3beta, the inactive form of glycogen synthase kinase-3beta (GSK-3beta). Nickel 13-19 glycogen synthase kinase 3 beta Homo sapiens 261-270 25462802-5 2015 A strategy has been developed to purify the insoluble MEX67 using a nickel affinity column with chelating Sepharose fast flow media, after solubilizing with sodium lauroyl sarcosinate (Sarkosyl). Nickel 68-74 Mex67p Saccharomyces cerevisiae S288C 54-59 25832279-4 2015 Using the proposed technique, we successfully acquired high-resolution strain maps of the crack tip field in a nickel superalloy sample at 1000 C. Nickel 111-117 TOR signaling pathway regulator Homo sapiens 96-99 25155647-2 2015 Herein, a straightforward method is demonstrated for efficient encapsidation of magnetic nanoparticles into the engineered virus-like particle (VLP) through the affinity of histidine tags for the nickel- nitrilotriacetic acid (NTA) chelate. Nickel 196-202 VHL like Homo sapiens 144-147 25458486-1 2015 Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Nickel 0-6 toll like receptor 4 Homo sapiens 105-111 25916440-0 2015 [The effect of nickel-smelting fumes on the expression of bcl-2 and bax in NIH/3T3 cells]. Nickel 15-21 B cell leukemia/lymphoma 2 Mus musculus 58-63 25916440-0 2015 [The effect of nickel-smelting fumes on the expression of bcl-2 and bax in NIH/3T3 cells]. Nickel 15-21 BCL2-associated X protein Mus musculus 68-71 25916440-1 2015 OBJECTIVE: To investigate the effect of nickel-smelting fumes on the expression of bcl-2 and bax in mammalian cells. Nickel 40-46 BCL2 apoptosis regulator Homo sapiens 83-88 25916440-1 2015 OBJECTIVE: To investigate the effect of nickel-smelting fumes on the expression of bcl-2 and bax in mammalian cells. Nickel 40-46 BCL2 associated X, apoptosis regulator Homo sapiens 93-96 25916440-8 2015 the expression of bcl-2 significantly increased in groups of 6.25, 12.50, 25.00 microg/ml nickel-smelting fumes (0.58 +- 0.01, 0.6 3+- 0.01 and 0.57 +- 0.01) and decreased in groups of 50.00, 100.00 microg/m nickel-smelting fume (0.35 +- 0.01 and 0.27 +- 0.01) as compared with that of the control group (P < 0.05). Nickel 90-96 B cell leukemia/lymphoma 2 Mus musculus 18-23 25916440-8 2015 the expression of bcl-2 significantly increased in groups of 6.25, 12.50, 25.00 microg/ml nickel-smelting fumes (0.58 +- 0.01, 0.6 3+- 0.01 and 0.57 +- 0.01) and decreased in groups of 50.00, 100.00 microg/m nickel-smelting fume (0.35 +- 0.01 and 0.27 +- 0.01) as compared with that of the control group (P < 0.05). Nickel 208-214 B cell leukemia/lymphoma 2 Mus musculus 18-23 25916440-9 2015 And the expression of bax significantly decreased in group of 6.25 microg/ml nickel-smelting fumes (0.58 +- 0.00) and increased in groups of 50.00, 100.00 microg/m nickel-smelting fumes (0.71 +- 0.01 and 0.78 +- 0.02) as compared with that of the control group (P < 0.05). Nickel 77-83 BCL2-associated X protein Mus musculus 22-25 25916440-9 2015 And the expression of bax significantly decreased in group of 6.25 microg/ml nickel-smelting fumes (0.58 +- 0.00) and increased in groups of 50.00, 100.00 microg/m nickel-smelting fumes (0.71 +- 0.01 and 0.78 +- 0.02) as compared with that of the control group (P < 0.05). Nickel 164-170 BCL2-associated X protein Mus musculus 22-25 25533110-0 2015 In situ synthesis of a NiS/Ni3S2 nanorod composite array on Ni foil as a FTO-free counter electrode for dye-sensitized solar cells. Nickel 23-26 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 73-76 25532100-0 2015 Nickel catalyzed dealkoxylative C(sp2)-C(sp3) cross coupling reactions--stereospecific synthesis of allylsilanes from enol ethers. Nickel 0-6 Sp2 transcription factor Homo sapiens 32-37 25580509-1 2015 Crystal structures of nickel-dependent superoxide dismutases (NiSODs) reveal the presence of a H-bonding network formed between the NH group of the apical imidazole ligand from His1 and the Glu17 carboxylate from a neighboring subunit in the hexameric enzyme. Nickel 22-28 viral integration site 1 Homo sapiens 177-181 25303728-4 2015 We report two cases of contact allergy to potassium dichromate, nickel and cobalt, where CTCL was diagnosed in one patient, and a diagnosis of CTCL is imminent in the other. Nickel 64-70 TSPY like 2 Homo sapiens 89-93 25256809-8 2015 T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Nickel 46-52 interleukin 4 Homo sapiens 159-163 25256809-8 2015 T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Nickel 46-52 interleukin 6 Homo sapiens 165-169 25256809-8 2015 T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Nickel 46-52 C-X-C motif chemokine ligand 8 Homo sapiens 171-175 25256809-11 2015 Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs. Nickel 109-115 interleukin 6 Homo sapiens 129-133 25256809-11 2015 Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs. Nickel 109-115 C-X-C motif chemokine ligand 8 Homo sapiens 138-142 25324152-7 2015 Elevated levels of urinary nickel were associated with higher fasting glucose, glycated haemoglobin A1c, insulin and homeostatic model assessment of insulin resistance (all P<0.01). Nickel 27-33 insulin Homo sapiens 105-112 25324152-7 2015 Elevated levels of urinary nickel were associated with higher fasting glucose, glycated haemoglobin A1c, insulin and homeostatic model assessment of insulin resistance (all P<0.01). Nickel 27-33 insulin Homo sapiens 149-156 25449906-11 2015 By contrast, overexpression of SIGMAR1 reduced the accumulation of NIs containing mutant huntingtin. Nickel 67-70 sigma non-opioid intracellular receptor 1 Homo sapiens 31-38 25449906-11 2015 By contrast, overexpression of SIGMAR1 reduced the accumulation of NIs containing mutant huntingtin. Nickel 67-70 huntingtin Homo sapiens 89-99 25517793-2 2015 Through a dry transfer technique and a metal-catalyzed graphene treatment process, nickel-etched-graphene electrodes were fabricated on MoS2 that yield contact resistance as low as 200 Omega mum. Nickel 83-89 latexin Homo sapiens 193-196 25446071-0 2015 Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. Nickel 30-36 tumor protein p63 Homo sapiens 73-76 25621996-10 2015 At the end of 131I therapy, CNE-2Z-NIS xenograft tumor cells expressed higher levels of NIS and caspase-3 and lower levels of Ki-67. Nickel 35-38 caspase 3 Homo sapiens 96-105 25539022-0 2015 Electrocatalytic proton reduction by dimeric nickel complex of a sterically demanding pincer-type NS2 aminobis(thiophenolate) ligand. Nickel 45-51 NS2 Homo sapiens 98-101 25446071-0 2015 Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. Nickel 30-36 tumor protein p73 Homo sapiens 81-84 25446071-3 2015 Here we report for the first time that cadmium, nickel and cobalt, which have already been shown to disturb various DNA repair mechanisms, can also influence p63 and p73 sequence-specific DNA binding activity and transactivation of p53 family target genes. Nickel 48-54 tumor protein p63 Homo sapiens 158-161 25446071-3 2015 Here we report for the first time that cadmium, nickel and cobalt, which have already been shown to disturb various DNA repair mechanisms, can also influence p63 and p73 sequence-specific DNA binding activity and transactivation of p53 family target genes. Nickel 48-54 tumor protein p73 Homo sapiens 166-169 25446071-3 2015 Here we report for the first time that cadmium, nickel and cobalt, which have already been shown to disturb various DNA repair mechanisms, can also influence p63 and p73 sequence-specific DNA binding activity and transactivation of p53 family target genes. Nickel 48-54 tumor protein p53 Homo sapiens 232-235 25446071-9 2015 Nickel and cobalt abolished DNA-p53 interaction at sub-millimolar concentrations while inhibition of p63 and p73 DNA binding was observed at millimolar concentrations. Nickel 0-6 tumor protein p53 Homo sapiens 32-35 25601470-4 2015 Nickel-induced oral tolerance is another immune tolerance model that is induced by the contact allergen Nickel and leads to the generation of Nickel-specific CD4(+) CD25(+) T regulatory cells after oral exposure. Nickel 0-6 CD4 molecule Homo sapiens 158-161 25601470-4 2015 Nickel-induced oral tolerance is another immune tolerance model that is induced by the contact allergen Nickel and leads to the generation of Nickel-specific CD4(+) CD25(+) T regulatory cells after oral exposure. Nickel 104-110 CD4 molecule Homo sapiens 158-161 25601470-4 2015 Nickel-induced oral tolerance is another immune tolerance model that is induced by the contact allergen Nickel and leads to the generation of Nickel-specific CD4(+) CD25(+) T regulatory cells after oral exposure. Nickel 104-110 CD4 molecule Homo sapiens 158-161 26370556-6 2015 Although both the sodium/iodide symporter (NIS), an essential transporter of iodide from blood into the thyroid, and MCT8, a transporter of synthesized TH from the gland, were co-localized on the basolateral membrane of rat thyrocytes in vivo, Tg decreased NIS expression and increased the expression of MCT8 by counteracting TSH action. Nickel 257-260 solute carrier family 16 member 2 Rattus norvegicus 117-121 25335952-3 2014 Spin change is induced by changing the coordination number of a nickel complex. Nickel 64-70 spindlin 1 Homo sapiens 0-4 25636536-2 2015 Patients with CTD often report hypersensitivity to nickel. Nickel 51-57 CTD Homo sapiens 14-17 25997964-4 2015 SP5.2/tTF was expressed in E. coli and then purified on a nickel-affinity chromatography column. Nickel 58-64 ras homolog family member H Homo sapiens 6-9 25997964-10 2015 SP5.2/tTF was abundantly expressed in bacterial cells and efficiently purified by nickel-affinity chromatography. Nickel 82-88 ras homolog family member H Homo sapiens 6-9 26193209-2 2015 The purpose of this study was to compare the in vivo effect of nickel and copper compounds on the oral mucosa cells, including their ability to induce cell death, by analyzing the cytochrome c (cyt. Nickel 63-69 cytochrome c, somatic Homo sapiens 180-192 26662142-2 2015 AIM: To highlight the expression of vascular endothelial growth factor (VEGF) in human paraprosthetic gingival mucosa exposed to nickel and copper compounds using the immunohistochemical technique. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 36-70 26662142-2 2015 AIM: To highlight the expression of vascular endothelial growth factor (VEGF) in human paraprosthetic gingival mucosa exposed to nickel and copper compounds using the immunohistochemical technique. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 72-76 26021087-3 2015 The coding sequence of hCRY1 was inserted into prokaryotic expression plasmid pET28a(+), and this protein was purified from Escherichia coli BL21(DE3) after IPTG induction, ultrasonication, inclusion body dissolution, gradient dialysis, nickel column purification and ultrafiltration. Nickel 237-243 cryptochrome circadian regulator 1 Homo sapiens 23-28 25354849-0 2014 Molecular structure and spectroscopic properties of a nickel-bridged {Ni(Ph3P)}2(mu2-eta(2), eta(2)-C60)2 dimer. Nickel 54-60 endothelin receptor type A Homo sapiens 85-88 25354849-0 2014 Molecular structure and spectroscopic properties of a nickel-bridged {Ni(Ph3P)}2(mu2-eta(2), eta(2)-C60)2 dimer. Nickel 54-60 endothelin receptor type A Homo sapiens 93-96 25354849-3 2014 The nickel atoms are bonded in an eta(2) coordination mode with Ni-C distances of 2.001(3)-2.037(3) A and a close approach of the fullerenes with a 9.716 A center-to-center distance. Nickel 4-10 endothelin receptor type A Homo sapiens 34-37 25527688-6 2014 The patient has been successfully treated with the insertion of a Memokath 051 stent (PNN Medical A/S, Denmark), which is a thermoexpandable, nickel-titanium alloy stent. Nickel 142-148 pinin, desmosome associated protein Homo sapiens 86-89 25384112-0 2014 Highly efficient activation of organosilanes with eta2-aldehyde nickel complexes: key for catalytic syntheses of aryl-, vinyl-, and alkynyl-benzoxasiloles. Nickel 64-70 DNA polymerase iota Homo sapiens 50-54 25172132-9 2014 We show that the thrombin-mediated cleavage of two histidine tags from the purified recombinant protein and the adsorption of these histidine tags and their associated endotoxins to a nickel affinity column result in an appreciable depletion of the endotoxins in the purified protein fraction. Nickel 184-190 coagulation factor II, thrombin Homo sapiens 17-25 25234361-4 2014 Sodium iodide symporter (NIS) mediates iodide influx, and NIS expression and function can be selectively enhanced in thyroid cells by thyroid-stimulating hormone. Nickel 25-28 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 0-23 25293653-0 2014 Enhanced visible-light photocatalytic H2 production by Znx Cd1-x S modified with earth-abundant nickel-based cocatalysts. Nickel 96-102 CD1c molecule Homo sapiens 59-62 25293653-1 2014 The application of various earth-abundant Ni species, such as NiS, Ni, Ni(OH)2 , and NiO, as a co-catalyst in a Znx Cd1-x S system for visible-light photocatalytic H2 production was investigated for the first time. Nickel 62-65 CD1c molecule Homo sapiens 116-119 25293653-2 2014 The loading of Ni or NiS enhanced the photocatalytic activity of Znx Cd1-x S because they could promote the electron transfer at the interface with Znx Cd1-x S and catalyze the H2 evolution. Nickel 21-24 CD1c molecule Homo sapiens 69-72 25293653-2 2014 The loading of Ni or NiS enhanced the photocatalytic activity of Znx Cd1-x S because they could promote the electron transfer at the interface with Znx Cd1-x S and catalyze the H2 evolution. Nickel 21-24 CD1c molecule Homo sapiens 152-155 25463665-1 2014 Two nickel(II) complexes with formula NiL1 and NiL2 (HL1 = S-allyl-4-methoxybenzylidene hydrazinecarbodithioate, HL2 = S-allyl-1-napthylidenehydrazinecarbodithioate) have been synthesized and characterized by elemental analysis, FT-IR, NMR, UV-vis spectroscopy and ESI mass spectrometry. Nickel 4-10 intelectin 1 Homo sapiens 53-56 25319483-2 2014 For this purpose, we constructed a lentiviral vector (Lv-EF1alpha-NIS-IRES-EGFP) expressing NIS and enhanced green fluorescent protein (EGFP), and introduced it into BMSCs at different multiplicities of infection (MOI). Nickel 66-69 Transcription factor EF1(a) Rattus norvegicus 57-65 25463665-7 2014 In addition, nickel complexes 1 and 2 shows better binding propensity to the bovine serum albumin (BSA) protein, giving a Ksv value 5.8 x 10(4), 4.47 x 10(4) respectively. Nickel 13-19 albumin Bos taurus 84-97 25463665-7 2014 In addition, nickel complexes 1 and 2 shows better binding propensity to the bovine serum albumin (BSA) protein, giving a Ksv value 5.8 x 10(4), 4.47 x 10(4) respectively. Nickel 13-19 albumin Bos taurus 99-102 24945110-3 2014 In this study, we explored the effect of orchidectomy (ORX) on the expression of SRC-1 in the adult male mice using nickel-intensified immunohistochemistry. Nickel 116-122 nuclear receptor coactivator 1 Mus musculus 81-86 25163803-0 2014 ZAT11, a zinc finger transcription factor, is a negative regulator of nickel ion tolerance in Arabidopsis. Nickel 70-76 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 0-5 25163803-7 2014 ZAT11 OE enhanced the elongation of primary root but reduced the metal tolerance against nickel ion (Ni(2+)). Nickel 89-95 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 0-5 25501180-7 2014 The fusion protein PET-AmIL-18 was purified by nickel affinity column chromatography and verified by sodium dodecyl sulfate polyacrylamide gel electrophoresis and Western blot analysis. Nickel 47-53 interleukin-18 Ailuropoda melanoleuca 23-30 25239916-8 2014 The effects of CAIP and nickel are completely lost in CaN-Aalpha(-/-) ASMCs. Nickel 24-30 histocompatibility 2, class II antigen A, alpha Mus musculus 58-64 25190023-3 2014 The purified EC1-GLuc was conjugated with a nickel-chelating liposome to construct the EC1-GLuc-liposome. Nickel 44-50 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 13-16 25190023-3 2014 The purified EC1-GLuc was conjugated with a nickel-chelating liposome to construct the EC1-GLuc-liposome. Nickel 44-50 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 87-90 25458692-3 2014 PdCl2 sol was adsorbed on MFT/AC, which was then immersed in spent electroless nickel plating bath; then nano-nickel could be reduced by ascorbic acid to form a nano-nickel coating on the activated carbon composite (Ni/AC) in situ. Nickel 110-116 solute carrier family 25 member 32 Homo sapiens 26-29 25458692-3 2014 PdCl2 sol was adsorbed on MFT/AC, which was then immersed in spent electroless nickel plating bath; then nano-nickel could be reduced by ascorbic acid to form a nano-nickel coating on the activated carbon composite (Ni/AC) in situ. Nickel 110-116 solute carrier family 25 member 32 Homo sapiens 26-29 26300567-1 2014 Solar-light-driven H2 production in water with a [NiFeSe]-hydrogenase (H2ase) and a bioinspired synthetic nickel catalyst (NiP) in combination with a heptazine carbon nitride polymer, melon (CNx), is reported. Nickel 106-112 relaxin 2 Homo sapiens 19-21 25116723-5 2014 In the case of the application of 1,1-bis(diphenylphosphino)methane as a neutral ligand, a dinuclear nickelalactone species [(mu-dppm)(Ni{CH2C(CH3)C(CH3)CH2COO})2] (3) was isolated in which the two nickel atoms realize different coordination geometries (SP-4 and SPY-5) in the solid state. Nickel 101-107 Sp4 transcription factor Homo sapiens 254-258 25199691-2 2014 Acquisition of Ni(II) is mediated by either permeases or ABC-importers, the latter including a subclass that involves an extracytoplasmic nickel-binding protein, Ni-BP. Nickel 138-144 trafficking protein particle complex subunit 9 Homo sapiens 162-167 25199691-4 2014 These are different from that previously described for Escherichia coli Ni-BP NikA, known to bind nickel via a nickelophore, and indicate a variegated ligand selectivity for Ni-BPs. Nickel 98-104 trafficking protein particle complex subunit 9 Homo sapiens 72-77 25040758-0 2014 Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway. Nickel 25-31 myeloid differentiation primary response gene 88 Mus musculus 69-74 25040758-0 2014 Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway. Nickel 40-46 myeloid differentiation primary response gene 88 Mus musculus 69-74 25040758-10 2014 The allergic response to nickel following epicutaneous exposure is MyD88-dependent and interleukin (IL)-1 receptor-dependent, but independent of toll-like receptor (TLR)-4. Nickel 25-31 myeloid differentiation primary response gene 88 Mus musculus 67-72 25040758-11 2014 CONCLUSION: This new model for nickel allergy that reflects epicutaneous exposure to nickel in humans shows that nickel allergy is dependent on MyD88 and IL-1 receptor signalling, but independent of TLR4. Nickel 31-37 MYD88 innate immune signal transduction adaptor Homo sapiens 144-149 25040758-11 2014 CONCLUSION: This new model for nickel allergy that reflects epicutaneous exposure to nickel in humans shows that nickel allergy is dependent on MyD88 and IL-1 receptor signalling, but independent of TLR4. Nickel 85-91 MYD88 innate immune signal transduction adaptor Homo sapiens 144-149 25040758-11 2014 CONCLUSION: This new model for nickel allergy that reflects epicutaneous exposure to nickel in humans shows that nickel allergy is dependent on MyD88 and IL-1 receptor signalling, but independent of TLR4. Nickel 85-91 MYD88 innate immune signal transduction adaptor Homo sapiens 144-149 24711049-0 2014 Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients. Nickel 0-6 tumor protein p53 Homo sapiens 73-76 24711049-3 2014 This study assessed whether nickel exposure increased the occurrence of p53 mutations due to DNA repair inhibition by nickel. Nickel 28-34 tumor protein p53 Homo sapiens 72-75 24711049-3 2014 This study assessed whether nickel exposure increased the occurrence of p53 mutations due to DNA repair inhibition by nickel. Nickel 118-124 tumor protein p53 Homo sapiens 72-75 24711049-5 2014 Nickel levels in p53 mutant patients were significantly higher than those in p53 wild-type patients. Nickel 0-6 tumor protein p53 Homo sapiens 17-20 24711049-6 2014 When patients were divided into high- and low-nickel subgroups by median nickel level, the high-nickel subgroup of patients had an odds ratio (OR) of 3.25 for p53 mutation risk relative to the low-nickel subgroup patients. Nickel 46-52 tumor protein p53 Homo sapiens 159-162 24711049-6 2014 When patients were divided into high- and low-nickel subgroups by median nickel level, the high-nickel subgroup of patients had an odds ratio (OR) of 3.25 for p53 mutation risk relative to the low-nickel subgroup patients. Nickel 73-79 tumor protein p53 Homo sapiens 159-162 24711049-6 2014 When patients were divided into high- and low-nickel subgroups by median nickel level, the high-nickel subgroup of patients had an odds ratio (OR) of 3.25 for p53 mutation risk relative to the low-nickel subgroup patients. Nickel 73-79 tumor protein p53 Homo sapiens 159-162 24711049-6 2014 When patients were divided into high- and low-nickel subgroups by median nickel level, the high-nickel subgroup of patients had an odds ratio (OR) of 3.25 for p53 mutation risk relative to the low-nickel subgroup patients. Nickel 73-79 tumor protein p53 Homo sapiens 159-162 24711049-7 2014 The OR for p53 mutation risk of lifetime non-smokers, particularly females, in the high-nickel subgroup was greater than that in the low-nickel subgroup. Nickel 88-94 tumor protein p53 Homo sapiens 11-14 24711049-7 2014 The OR for p53 mutation risk of lifetime non-smokers, particularly females, in the high-nickel subgroup was greater than that in the low-nickel subgroup. Nickel 137-143 tumor protein p53 Homo sapiens 11-14 24711049-10 2014 Therefore, increased risk of p53 mutation due to defective DNA repair caused by high nickel levels in lung tissues may be one mechanism by which nickel exposure contributes to lung cancer development, especially in lifetime female non-smokers. Nickel 85-91 tumor protein p53 Homo sapiens 29-32 24711049-10 2014 Therefore, increased risk of p53 mutation due to defective DNA repair caused by high nickel levels in lung tissues may be one mechanism by which nickel exposure contributes to lung cancer development, especially in lifetime female non-smokers. Nickel 145-151 tumor protein p53 Homo sapiens 29-32 24972299-3 2014 In variable-temperature NH3 decomposition experiments, using a simple flow reactor, the Na/NaNH2 system shows superior performance to supported nickel and ruthenium catalysts, reaching 99.2% decomposition efficiency with 0.5 g of NaNH2 in a 60 sccm NH3 flow at 530 C. As an abundant and inexpensive material, the development of NaNH2-based NH3 cracking systems may promote the utilization of NH3 for sustainable energy storage purposes. Nickel 144-150 neuraminidase 1 Homo sapiens 91-95 25100546-1 2014 A nickel catalyst promotes the multicomponent coupling reaction of diketene, an alkyne, and Me2Zn to provide 3-methylene-4-hexenoic acids in excellent yields. Nickel 2-8 malic enzyme 2 Homo sapiens 92-95 25089007-8 2014 SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron>zinc>nickel=cadmium>cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1. Nickel 20-26 solute carrier family 39 (zinc transporter), member 1 Mus musculus 68-73 25089007-8 2014 SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron>zinc>nickel=cadmium>cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1. Nickel 20-26 solute carrier family 39 (zinc transporter), member 1 Mus musculus 237-242 25089007-8 2014 SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron>zinc>nickel=cadmium>cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1. Nickel 116-122 solute carrier family 39 (zinc transporter), member 1 Mus musculus 68-73 25220231-3 2014 Our results showed that the nickel induced in rats an oxidative stress objectified by elevated levels of thiobarbituric acid-reactive substances and conjugated dienes associated with inhibition of the activity of the antioxidant defense system such as glutathione peroxidase, superoxide dismutase and catalase in the liver, kidney, spleen and erythrocyte. Nickel 28-34 catalase Rattus norvegicus 301-309 25182986-0 2014 [Effect of hOGG1 expression level on oxidative DNA damage among workers exposed to nickel in stainless steel production environment]. Nickel 83-89 8-oxoguanine DNA glycosylase Homo sapiens 11-16 24939618-5 2014 Human epidermal growth factor receptor (hEGFR)-specific peptide was also attached to the same particles via a nickel-nitrilotriacetic acid linker attached to the chitosan. Nickel 110-116 epidermal growth factor receptor Homo sapiens 40-45 24980266-1 2014 Accurate values for the energies of stacking interactions of nickel- and copper-based six-membered chelate rings with benzene are calculated at the CCSD(T)/CBS level. Nickel 61-67 cystathionine beta-synthase Homo sapiens 156-159 24768652-9 2014 Nickel demonstrated the highest immune activation, with potent inductions of innate immunity, TH1/TH17 and a TH22 component. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 94-97 25182986-1 2014 OBJECTIVE: To study the excision repair capacity of human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) for 8-OH-dG and the oxidative DNA damage among workers exposed to nickel in stainless steel production environment. Nickel 165-171 8-oxoguanine DNA glycosylase Homo sapiens 92-97 25182986-8 2014 Different types of nickel-exposed workers all showed significant differences from the control group in hOGG1 mRNA level (P < 0.05). Nickel 19-25 8-oxoguanine DNA glycosylase Homo sapiens 103-108 25182986-10 2014 Pearson correlation analysis showed that urinary 8-OH-dG level was positively correlated with hOGG1 mRNA level (r = 0.993) in different types of nickel-exposed workers, and the correlation was significant at alpha = 0.01 (P < 0.05); urinary 8-OH-dG level also showed a positive correlation with hOGG1 mRNA level in nickel-exposed workers with different working years (r = 0.968), and the correlation was significant at alpha = 0.01 (P < 0.05). Nickel 145-151 8-oxoguanine DNA glycosylase Homo sapiens 94-99 25182986-10 2014 Pearson correlation analysis showed that urinary 8-OH-dG level was positively correlated with hOGG1 mRNA level (r = 0.993) in different types of nickel-exposed workers, and the correlation was significant at alpha = 0.01 (P < 0.05); urinary 8-OH-dG level also showed a positive correlation with hOGG1 mRNA level in nickel-exposed workers with different working years (r = 0.968), and the correlation was significant at alpha = 0.01 (P < 0.05). Nickel 145-151 8-oxoguanine DNA glycosylase Homo sapiens 298-303 24673390-0 2014 The nickel dose-response relationship by filaggrin genotype (FLG). Nickel 4-10 filaggrin Homo sapiens 41-50 24673390-0 2014 The nickel dose-response relationship by filaggrin genotype (FLG). Nickel 4-10 filaggrin Homo sapiens 61-64 24673390-2 2014 One probable contributor is filaggrin, which binds nickel avidly. Nickel 51-57 filaggrin Homo sapiens 28-37 24673390-3 2014 Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults. Nickel 161-167 filaggrin Homo sapiens 0-9 24673390-3 2014 Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults. Nickel 161-167 filaggrin Homo sapiens 16-19 24487305-6 2014 Peripheral blood mononuclear cells from nickel-allergic patients, but not nonallergic controls, show significant IL-9 production in response to nickel. Nickel 40-46 interleukin 9 Homo sapiens 113-117 24487305-6 2014 Peripheral blood mononuclear cells from nickel-allergic patients, but not nonallergic controls, show significant IL-9 production in response to nickel. Nickel 144-150 interleukin 9 Homo sapiens 113-117 24487305-7 2014 Blocking studies with mAbs to HLA-DR (but not HLA-A, -B, -C) or chloroquine significantly reduced this nickel-specific IL-9 production. Nickel 103-109 interleukin 9 Homo sapiens 119-123 24900148-3 2014 The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Nickel 80-83 solute carrier family 2 member 1 Homo sapiens 19-25 24792994-0 2014 A new PC(sp(3))P ligand and its coordination chemistry with low-valent iron, cobalt and nickel complexes. Nickel 88-94 Sp3 transcription factor pseudogene Homo sapiens 6-16 24792994-1 2014 A new PC(sp(3))P ligand N,N"-bis(diphenylphosphino)dipyrromethane [PCH2P] (1) was prepared and its iron, cobalt and nickel chemistry was explored. Nickel 116-122 Sp3 transcription factor pseudogene Homo sapiens 6-16 24898970-1 2014 A new quaternary dicerium lithium/nickel disilicide, Ce2Li0.39Ni1.61Si2, crystallizes as a new structure type of intermetallic compounds closely related to the AlB2 family. Nickel 34-40 afamin Homo sapiens 160-164 24900148-8 2014 A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Nickel 64-67 solute carrier family 2 member 1 Homo sapiens 53-59 24989299-6 2014 The purified TRX-Jagged1 protein could be obtained via the Nickel affinity chromatography, and then confirmed by Western Blot. Nickel 59-65 jagged canonical Notch ligand 1 Homo sapiens 17-24 24157460-0 2014 Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis. Nickel 64-70 filaggrin Homo sapiens 0-9 24670797-0 2014 A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice. Nickel 52-58 thymic stromal lymphopoietin Mus musculus 20-48 24806561-0 2014 Relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 29-35 cyclin dependent kinase inhibitor 2B Homo sapiens 55-58 24806561-0 2014 Relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 29-35 cyclin dependent kinase inhibitor 2A Homo sapiens 60-63 24806561-0 2014 Relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 86-92 cyclin dependent kinase inhibitor 2B Homo sapiens 55-58 24806561-0 2014 Relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 86-92 cyclin dependent kinase inhibitor 2A Homo sapiens 60-63 24806561-1 2014 OBJECTIVE: The purpose of this study was to investigate the relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 89-95 cyclin dependent kinase inhibitor 2B Homo sapiens 115-118 24806561-1 2014 OBJECTIVE: The purpose of this study was to investigate the relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 89-95 cyclin dependent kinase inhibitor 2A Homo sapiens 120-123 24806561-1 2014 OBJECTIVE: The purpose of this study was to investigate the relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 146-152 cyclin dependent kinase inhibitor 2B Homo sapiens 115-118 24806561-1 2014 OBJECTIVE: The purpose of this study was to investigate the relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Nickel 146-152 cyclin dependent kinase inhibitor 2A Homo sapiens 120-123 24806561-7 2014 The multiple logistic analysis showed that workers having higher urinary nickel were at the higher risk of methylation of p15 (P = 0.024). Nickel 73-79 cyclin dependent kinase inhibitor 2B Homo sapiens 122-125 24806561-8 2014 CONCLUSIONS: The levels of urinary nickel were significantly associated with the methylation of p15. Nickel 35-41 cyclin dependent kinase inhibitor 2B Homo sapiens 96-99 24576660-4 2014 A 34kDa mGLYAT protein was expressed in Escherichia coli and purified to homogeneity by nickel affinity chromatography to a final yield of 2.5mg/L culture. Nickel 88-94 glycine-N-acyltransferase Mus musculus 8-14 25169089-6 2014 The activities of CAT were significantly reduced in groups of 25, 50, and 100 microg/ml nickel smelting fume as compared with that of the control group (P < 0.05). Nickel 88-94 catalase Mus musculus 18-21 24448832-0 2014 Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. Nickel 0-6 ATP binding cassette subfamily B member 1 Canis lupus familiaris 136-141 24448832-3 2014 Here, we investigated the role of ABCB1 in nickel-induced stress signaling mediated by reactive oxygen species (ROS) and ceramides. Nickel 43-49 ATP binding cassette subfamily B member 1 Canis lupus familiaris 34-39 24448832-6 2014 ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. Nickel 23-29 ATP binding cassette subfamily B member 1 Canis lupus familiaris 0-5 24448832-6 2014 ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. Nickel 112-118 ATP binding cassette subfamily B member 1 Canis lupus familiaris 0-5 24448832-6 2014 ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. Nickel 112-118 ATP binding cassette subfamily B member 1 Canis lupus familiaris 53-58 24448832-7 2014 Moreover, nickel toxicity was attenuated in renal MDCK cells stably overexpressing ABCB1. Nickel 10-16 ATP binding cassette subfamily B member 1 Canis lupus familiaris 83-88 24448832-12 2014 In conclusion, nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides. Nickel 15-21 ATP binding cassette subfamily B member 1 Canis lupus familiaris 158-163 24158569-0 2014 Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway. Nickel 0-6 interleukin 1 beta Homo sapiens 15-32 24158569-0 2014 Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway. Nickel 0-6 NLR family pyrin domain containing 3 Homo sapiens 51-56 24158569-0 2014 Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway. Nickel 0-6 PYD and CARD domain containing Homo sapiens 57-60 24158569-0 2014 Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway. Nickel 0-6 caspase 1 Homo sapiens 61-70 24691273-6 2014 Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-kappaB, and a greater decrease of p53 transcription activity than fine particles. Nickel 38-44 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 87-91 24691273-6 2014 Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-kappaB, and a greater decrease of p53 transcription activity than fine particles. Nickel 38-44 tumor protein p53 Homo sapiens 133-136 24691273-7 2014 Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. Nickel 37-43 RAS related Homo sapiens 108-113 24691273-7 2014 Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. Nickel 37-43 MYC proto-oncogene, bHLH transcription factor Homo sapiens 115-120 24691273-7 2014 Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. Nickel 37-43 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 122-127 24691273-7 2014 Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. Nickel 37-43 RELA proto-oncogene, NF-kB subunit Homo sapiens 129-132 24691273-7 2014 Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. Nickel 37-43 nuclear factor kappa B subunit 1 Homo sapiens 138-141 24486813-9 2014 The N-terminally histidine-tagged ESP4 fusion protein was expressed in Escherichia coli as inclusion bodies, which were solubilized and purified by nickel affinity chromatography. Nickel 148-154 exocrine gland secreted peptide 4 Mus musculus 34-38 24522982-0 2014 Nickel-catalyzed Csp2-Csp3 bond formation by carbon-fluorine activation. Nickel 0-6 regulator of calcineurin 2 Homo sapiens 17-21 24577088-4 2014 This study aimed to investigate whether miR-210 modulates alterations in energy metabolism after nickel exposure through suppressing ISCU1/2 and inactivating ISCs-containing metabolic enzymes. Nickel 97-103 microRNA 210 Mus musculus 40-47 24125475-10 2014 Remarkably, the number and frequency of RORgammat(+) CD56(+) ILC3s, which are known to produce IL-22, were elevated in both nonlesional and lesional skin from patients with psoriasis compared with healthy skin and skin from patients with contact allergy to nickel. Nickel 257-263 interleukin 22 Homo sapiens 95-100 24424051-2 2014 In thyrocytes, activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) cascade also inhibits NIS expression and function. Nickel 111-114 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 29-58 24424051-2 2014 In thyrocytes, activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) cascade also inhibits NIS expression and function. Nickel 111-114 AKT serine/threonine kinase 1 Rattus norvegicus 84-87 24424051-6 2014 Moreover, I(-) inhibitory effect on NIS expression and function were abolished when the cells were previously treated with specific inhibitors of PI3K or Akt (Akt1/2 kinase inhibitor). Nickel 36-39 AKT serine/threonine kinase 1 Rattus norvegicus 154-157 24424051-6 2014 Moreover, I(-) inhibitory effect on NIS expression and function were abolished when the cells were previously treated with specific inhibitors of PI3K or Akt (Akt1/2 kinase inhibitor). Nickel 36-39 AKT serine/threonine kinase 1 Rattus norvegicus 159-182 24577088-0 2014 MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. Nickel 22-28 iron-sulfur cluster assembly enzyme Mus musculus 126-133 24577088-4 2014 This study aimed to investigate whether miR-210 modulates alterations in energy metabolism after nickel exposure through suppressing ISCU1/2 and inactivating ISCs-containing metabolic enzymes. Nickel 97-103 iron-sulfur cluster assembly enzyme Mus musculus 133-140 24577088-7 2014 The gain-of-function and loss-of-dysfunction assays revealed that miR-210 mediated the ISCU1/2 suppression, energy metabolism alterations, and ISC-containing metabolic enzyme inactivation after nickel exposure. Nickel 194-200 microRNA 210 Mus musculus 66-73 24577088-7 2014 The gain-of-function and loss-of-dysfunction assays revealed that miR-210 mediated the ISCU1/2 suppression, energy metabolism alterations, and ISC-containing metabolic enzyme inactivation after nickel exposure. Nickel 194-200 iron-sulfur cluster assembly enzyme Mus musculus 87-94 24577088-9 2014 Overall, these data suggest that repression of miR-210 on ISCU1/2 may contribute to HIF-1alpha-triggered alterations in energy metabolism after nickel exposure. Nickel 144-150 microRNA 210 Mus musculus 47-54 24577088-9 2014 Overall, these data suggest that repression of miR-210 on ISCU1/2 may contribute to HIF-1alpha-triggered alterations in energy metabolism after nickel exposure. Nickel 144-150 iron-sulfur cluster assembly enzyme Mus musculus 58-65 24577088-9 2014 Overall, these data suggest that repression of miR-210 on ISCU1/2 may contribute to HIF-1alpha-triggered alterations in energy metabolism after nickel exposure. Nickel 144-150 hypoxia inducible factor 1, alpha subunit Mus musculus 84-94 24519992-1 2014 The structure of a nickel complex of imidazoline-aminophenol (IAP) prepared from IAP with Ni(OAc)2 was elucidated as cis-bis(imidazolineaminophenoxide) [Ni(IAP)2]. Nickel 19-25 baculoviral IAP repeat containing 2 Homo sapiens 156-161 24169691-0 2014 Ni(II) binding to the 429-460 peptide fragment from human Toll like receptor (hTLR4): a crucial role for nickel-induced contact allergy? Nickel 105-111 toll like receptor 4 Homo sapiens 78-83 24441914-3 2014 Furthermore, a flexible electrode (G-gel@NF-2) was obtained by etching most of the nickel foam but maintains the conductive backbone of the nickel foam, which greatly reduces the total mass of the electrode (can be reduced from 30 mg cm(-2) to less than 5 mg cm(-2)), and can be compressed from a thickness of 1 mm to ~30 mum. Nickel 83-89 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 41-45 24441914-3 2014 Furthermore, a flexible electrode (G-gel@NF-2) was obtained by etching most of the nickel foam but maintains the conductive backbone of the nickel foam, which greatly reduces the total mass of the electrode (can be reduced from 30 mg cm(-2) to less than 5 mg cm(-2)), and can be compressed from a thickness of 1 mm to ~30 mum. Nickel 140-146 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 41-45 24441914-4 2014 With the aid of a conductive network composed of a small amount of nickel, G-gel@NF-2 still has good performance in high rate capability and displays excellent flexible properties. Nickel 67-73 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 81-85 24476084-1 2014 In this work, we show that the unique combination of a nickel catalyst and Cp2TiCl allows the direct conjugate addition of aryl and alkenyl iodides, bromides, and to a lesser extent, chlorides and triflates to alpha,beta-unsaturated carbonyls at room temperature, without requiring the previous formation of an organometallic nucleophile. Nickel 55-61 ceruloplasmin Homo sapiens 75-78 24502267-0 2014 Copper-assisted nickel catalyzed ligand-free C(sp2)-O cross-coupling of vinyl halides and phenols. Nickel 16-22 regulator of calcineurin 2 Homo sapiens 45-53 24036122-1 2014 This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. Nickel 72-78 glyoxalase I Homo sapiens 99-111 24296683-1 2014 The communication reports the synthesis, characterization, and magnetic behavior of a novel mu4-carbonato supported and imidazole capped ligated nickel cage [Ni8(mu-H2bpmp)4(mu4-CO3)4(ImH)8](NO3)4 2H2O (1) through self-assembly of ligand bound ferromagnetic Ni2 building blocks. Nickel 145-151 adaptor related protein complex 4 subunit mu 1 Homo sapiens 92-95 24296683-1 2014 The communication reports the synthesis, characterization, and magnetic behavior of a novel mu4-carbonato supported and imidazole capped ligated nickel cage [Ni8(mu-H2bpmp)4(mu4-CO3)4(ImH)8](NO3)4 2H2O (1) through self-assembly of ligand bound ferromagnetic Ni2 building blocks. Nickel 145-151 adaptor related protein complex 4 subunit mu 1 Homo sapiens 174-177 24499286-0 2014 Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet). Nickel 0-6 T-box 21 Mus musculus 114-119 24499286-0 2014 Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet). Nickel 0-6 T-box 21 Mus musculus 121-126 24497960-0 2014 Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. Nickel 11-17 POU class 5 homeobox 1 Homo sapiens 59-63 24252720-5 2014 We present here the use of the HR-MAS technology to obtain 2D NMR spectra of the MAGI-1 PDZ2/6 protein domain, C13-labeled, tagged with a His-tag and grafted on a Nickel affinity resin. Nickel 163-169 membrane associated guanylate kinase, WW and PDZ domain containing 1 Homo sapiens 81-87 24497960-5 2014 Cobalt and nickel induced a concentration-dependent increase of OCT4 and HIF-1alpha, but not NANOG or KLF4. Nickel 11-17 POU class 5 homeobox 1 Homo sapiens 64-68 24497960-5 2014 Cobalt and nickel induced a concentration-dependent increase of OCT4 and HIF-1alpha, but not NANOG or KLF4. Nickel 11-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 73-83 24497960-6 2014 OCT4 induced by cobalt and nickel was due primarily to protein stabilization because MG132 stabilized OCT4 in cells treated with either metals and because neither nickel nor cobalt significantly modulated its steady-state mRNA level. Nickel 27-33 POU class 5 homeobox 1 Homo sapiens 0-4 24497960-7 2014 OCT4 stabilization by cobalt and nickel was mediated largely through reactive oxygen species (ROS) as co-treatment with ascorbic acid abolished OCT4 increase. Nickel 33-39 POU class 5 homeobox 1 Homo sapiens 144-148 24497960-8 2014 Moreover, nickel and cobalt treatment increased sumoylation and mono-ubiquitination of OCT4 and K123 was crucial for mediating these modifications. Nickel 10-16 POU class 5 homeobox 1 Homo sapiens 87-91 24497960-9 2014 Combined, our observations suggest that nickel and cobalt may exert their reproductive toxicity through perturbing OCT4 activity in the stem cell compartment. Nickel 40-46 POU class 5 homeobox 1 Homo sapiens 115-119 23913721-2 2014 Specifically, it is shown that the phase lag of the long axis of nickel nanorods (magnetic core parameters: length 182 nm, diameter 26 nm) with respect to externally applied rotating magnetic fields significantly increases on the adhesion of bovine serum albumin (BSA) protein to their surfaces. Nickel 65-71 albumin Homo sapiens 249-262 27877647-4 2014 The respective enhancement of local magnetic moments at the Sigma5 (0.63 muB) and random (0.90 muB) grain boundaries in pure nickel was approximately 14 and 64% of the grain interior. Nickel 125-131 adaptor related protein complex 5 subunit sigma 1 Homo sapiens 60-66 24153398-2 2014 These ligands have been successfully coordinated to nickel affording complexes of the general type (Cp*-NHC(R))NiX (X = Cl, I). Nickel 52-58 BCL2 interacting protein 3 like Homo sapiens 111-114 23615737-4 2014 The vreh1 gene constructed in pET28a(+) vector was then heterologously overexpressed in Escherichia coli BL21(DE3), and the encoded protein was purified to homogeneity by nickel affinity chromatography. Nickel 171-177 bifunctional epoxide hydrolase 2-like Vigna radiata 4-9 23819433-4 2014 METHODS: The in vitro and in vivo effects of AMPK modulation on sodium-iodide symporter (NIS) protein levels and iodide uptake were examined in follicular rat thyroid cell-line cells and C57Bl6/J mice. Nickel 89-92 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 45-49 24243688-0 2014 Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Nickel 25-28 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 48-52 24243688-0 2014 Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Nickel 68-71 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 48-52 24243688-1 2014 The BRAF V600E mutation causes impaired expression of sodium iodide symporter (NIS) and radioiodine refractoriness of thyroid cancer, but the underlying mechanism remains undefined. Nickel 79-82 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 4-8 24243688-2 2014 In this study, we hypothesized that histone deacetylation at the NIS (SLC5A5) promoter was the mechanism. Nickel 65-68 solute carrier family 5 member 5 Homo sapiens 70-76 24243688-4 2014 We found that expression of stably or transiently transfected BRAF V600E inhibited NIS expression while the deacetylase inhibitor SAHA stimulated NIS expression in PCCL3 rat thyroid cells. Nickel 83-86 B-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 62-66 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 174-177 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 57-61 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 174-177 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 78-82 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 174-177 mitogen-activated protein kinase kinase 7 Homo sapiens 113-116 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 174-177 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 78-82 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 274-277 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 57-61 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 274-277 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 78-82 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 274-277 mitogen-activated protein kinase kinase 7 Homo sapiens 113-116 24243688-6 2014 In human thyroid cancer BCPAP cells harboring homozygous BRAF V600E mutation, BRAF V600E inhibitor, PLX4032, and MEK inhibitor, AZD6244, increased histone acetylation of the NIS promoter, suggesting that BRAF V600E normally maintained histone in a deacetylated state at the NIS promoter. Nickel 274-277 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 78-82 24243688-8 2014 Our findings not only reveal an epigenetic mechanism for BRAF V600E-promoted NIS silencing involving histone deacetylation at critical regulatory regions of the NIS promoter but also provide further support for our previously proposed combination therapy targeting major signaling pathways and histone deacetylase to restore thyroid gene expression for radioiodine treatment of thyroid cancer. Nickel 77-80 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 57-61 26155144-2 2014 In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6). Nickel 124-130 elastase, neutrophil expressed Homo sapiens 285-304 26155144-2 2014 In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6). Nickel 124-130 interleukin 6 Homo sapiens 346-359 26155144-2 2014 In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6). Nickel 124-130 interleukin 6 Homo sapiens 361-365 24600868-4 2014 It also consisted of variety of heavy metals such as zinc, magnesium, iron and nickel at concentrations of 1.39, 12.19, 2.39 and 0.72 mgL-1, respectively. Nickel 79-85 LLGL scribble cell polarity complex component 1 Homo sapiens 134-139 24579805-0 2014 Effects of nickel-smelting fumes on the regulation of NIH/3T3 cell viability, necrosis, and expression of hMLH1 and RASSF1A. Nickel 11-17 mutL homolog 1 Homo sapiens 106-111 24579805-0 2014 Effects of nickel-smelting fumes on the regulation of NIH/3T3 cell viability, necrosis, and expression of hMLH1 and RASSF1A. Nickel 11-17 Ras association (RalGDS/AF-6) domain family member 1 Mus musculus 116-123 24579805-6 2014 Real-time RT-PCR and Western blot analyses showed that exposure of cells to concentrations of >=100 microg/mL of nickel-smelting fumes upregulated the expression of hMLH1 and RASSF1A compared to the negative controls. Nickel 116-122 mutL homolog 1 Homo sapiens 168-173 24579805-6 2014 Real-time RT-PCR and Western blot analyses showed that exposure of cells to concentrations of >=100 microg/mL of nickel-smelting fumes upregulated the expression of hMLH1 and RASSF1A compared to the negative controls. Nickel 116-122 Ras association (RalGDS/AF-6) domain family member 1 Mus musculus 178-185 24579805-7 2014 These data suggest that nickel-smelting fumes could be toxic to cells, upregulating the expression of hMLH1 and RASSF1A and in turn inducing cell apoptosis and necrosis. Nickel 24-30 mutL homolog 1 Homo sapiens 102-107 24579805-7 2014 These data suggest that nickel-smelting fumes could be toxic to cells, upregulating the expression of hMLH1 and RASSF1A and in turn inducing cell apoptosis and necrosis. Nickel 24-30 Ras association (RalGDS/AF-6) domain family member 1 Mus musculus 112-119 23819433-5 2014 Activation of AMPK by metformin resulted in a strong reduction of iodide uptake (up to sixfold with 5 mM metformin after 96 h) and NIS protein levels in vitro, whereas AMPK inhibition by compound C not only stimulated iodide uptake but also enhanced NIS protein levels both in vitro (up to sevenfold with 1 muM compound C after 96 h) and in vivo (1.5-fold after daily injections with 20 mg/kg for 4 days). Nickel 131-134 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 23819433-5 2014 Activation of AMPK by metformin resulted in a strong reduction of iodide uptake (up to sixfold with 5 mM metformin after 96 h) and NIS protein levels in vitro, whereas AMPK inhibition by compound C not only stimulated iodide uptake but also enhanced NIS protein levels both in vitro (up to sevenfold with 1 muM compound C after 96 h) and in vivo (1.5-fold after daily injections with 20 mg/kg for 4 days). Nickel 250-253 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 23819433-12 2014 CONCLUSION: NIS expression and iodine uptake in thyrocytes can be modulated by metformin and compound C. These compounds exert their effect by modulation of AMPK, which, in turn, regulates the activation of the CRE element in the NIS promoter. Nickel 12-15 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 157-161 23819433-12 2014 CONCLUSION: NIS expression and iodine uptake in thyrocytes can be modulated by metformin and compound C. These compounds exert their effect by modulation of AMPK, which, in turn, regulates the activation of the CRE element in the NIS promoter. Nickel 230-233 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 157-161 24080332-3 2013 Following screening of fifteen metals, zinc and nickel were identified with a marked proinflammatory effect, as determined by ICAM-1 and IL-8 induction, on human umbilical vein endothelial cells (HUVECs). Nickel 48-54 intercellular adhesion molecule 1 Homo sapiens 126-132 24135713-1 2013 Nickel nanoparticles have been created in an organic-based matrix by the reaction of Ni(COD)2 (COD = 1,5-bis-cyclooctadiene) and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (TCNQF4). Nickel 0-6 COD2 Homo sapiens 85-93 24135713-2 2013 The size of the nickel nanoparticles can be controlled by the use of different solvents and inclusion of tetrahydrofuran (THF) within the reaction to stabilise the Ni(0) atoms from the Ni(COD)2. Nickel 16-22 COD2 Homo sapiens 188-193 24080332-5 2013 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel 84-90 nuclear factor kappa B subunit 1 Homo sapiens 130-138 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 82-88 toll like receptor 4 Homo sapiens 50-55 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 82-88 toll like receptor 4 Homo sapiens 126-131 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 82-88 nuclear factor kappa B subunit 1 Homo sapiens 158-166 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 181-187 toll like receptor 4 Homo sapiens 50-55 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 181-187 toll like receptor 4 Homo sapiens 126-131 24080332-7 2013 The finding demonstrated the differential role of TLR-4 in regulation of the zinc/nickel-induced inflammatory response, where TLR-4 played a dominant role in NFkappaB activation by nickel, but not by zinc. Nickel 181-187 nuclear factor kappa B subunit 1 Homo sapiens 158-166 24080332-8 2013 Moreover, inhibition of NFkappaB by adenovirus-mediated IkappaBalpha expression and Bay 11-7025, an inhibitor of cytokine-induced IkappaB-alpha phosphorylation, significantly attenuated the zinc/nickel-induced inflammatory responses, indicating the critical of NFkappaB in the process. Nickel 195-201 nuclear factor kappa B subunit 1 Homo sapiens 24-32 24080332-8 2013 Moreover, inhibition of NFkappaB by adenovirus-mediated IkappaBalpha expression and Bay 11-7025, an inhibitor of cytokine-induced IkappaB-alpha phosphorylation, significantly attenuated the zinc/nickel-induced inflammatory responses, indicating the critical of NFkappaB in the process. Nickel 195-201 NFKB inhibitor alpha Homo sapiens 130-143 24080332-8 2013 Moreover, inhibition of NFkappaB by adenovirus-mediated IkappaBalpha expression and Bay 11-7025, an inhibitor of cytokine-induced IkappaB-alpha phosphorylation, significantly attenuated the zinc/nickel-induced inflammatory responses, indicating the critical of NFkappaB in the process. Nickel 195-201 nuclear factor kappa B subunit 1 Homo sapiens 261-269 24320827-0 2013 Nickel affects xylem Sap RNase a and converts RNase A to a urease. Nickel 0-6 ribonuclease pancreatic Bos taurus 25-32 24320827-0 2013 Nickel affects xylem Sap RNase a and converts RNase A to a urease. Nickel 0-6 ribonuclease pancreatic Bos taurus 46-53 23969277-3 2013 Here we provide evidence that failure to recover down-regulated NIS by MEK inhibition is not specific to tumour cells. Nickel 64-67 mitogen-activated protein kinase kinase 7 Homo sapiens 71-74 23969277-4 2013 NIS mRNA levels remained repressed in TSH-stimulated primary thyroid cells co-treated with epidermal growth factor (EGF) and pan-MEK inhibitor U0126 in the presence of 5% fetal bovine serum or, independently of serum, in 3D cultured thyroid follicles. Nickel 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 129-132 23969277-9 2013 Together, this suggests that morphogenetic signals modify the expression of NIS and recovery response to MEK inhibition. Nickel 76-79 mitogen-activated protein kinase kinase 7 Homo sapiens 105-108 24078118-2 2013 After purification by nickel-affinity chromatography column, the recombinant neutral protease (rNPI) was confirmed to be N-glycosylated by periodicacid/Schiff"s base staining and Endo H digestion. Nickel 22-28 neuronal pentraxin 1 Rattus norvegicus 95-99 24080332-3 2013 Following screening of fifteen metals, zinc and nickel were identified with a marked proinflammatory effect, as determined by ICAM-1 and IL-8 induction, on human umbilical vein endothelial cells (HUVECs). Nickel 48-54 C-X-C motif chemokine ligand 8 Homo sapiens 137-141 24080332-4 2013 Inhibiting protein expression of myeloid differentiation primary response protein-88 (MyD88), a Toll-like receptor (TLR) adaptor acting as a TLR-signaling transducer, significantly attenuated the zinc/nickel-induced inflammatory response, suggesting the critical roles of TLRs in the inflammatory response. Nickel 201-207 MYD88 innate immune signal transduction adaptor Homo sapiens 86-91 24080332-5 2013 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel 84-90 toll like receptor 4 Homo sapiens 12-17 24080332-5 2013 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel 84-90 toll like receptor 4 Homo sapiens 42-47 24080332-5 2013 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel 84-90 intercellular adhesion molecule 1 Homo sapiens 99-105 24080332-5 2013 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel 84-90 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 24164463-7 2013 IL-1Ra and IL-36Ra expression was quantified in mononuclear cells of nickel-sensitized patients challenged in vitro with nickel. Nickel 69-75 interleukin 1 receptor antagonist Homo sapiens 0-6 24164463-7 2013 IL-1Ra and IL-36Ra expression was quantified in mononuclear cells of nickel-sensitized patients challenged in vitro with nickel. Nickel 69-75 interleukin 36 receptor antagonist Homo sapiens 11-18 24164463-12 2013 Nickel induced IL-1Ra expression in lymphocytes of nickel-sensitized patients. Nickel 0-6 interleukin 1 receptor antagonist Homo sapiens 15-21 24164463-12 2013 Nickel induced IL-1Ra expression in lymphocytes of nickel-sensitized patients. Nickel 51-57 interleukin 1 receptor antagonist Homo sapiens 15-21 24035598-11 2013 The concentration of nickel was higher in the sweat of intrinsic AD than extrinsic AD patients (333.8 vs 89.4ng/g, P=0.0005) and inversely correlated with serum IgE levels. Nickel 21-27 immunoglobulin heavy constant epsilon Homo sapiens 161-164 24171447-10 2013 This is contrasted by the reaction of nickel, in which the equilibrium of phosphasilene 1 and the phosphinosilylene 6 [LSiP(TMS)2] was utilized for a better coordination of the silicon(II) moiety in comparison with phosphorus to the transition metal center. Nickel 38-44 serine incorporator 1 Homo sapiens 124-129 23968727-0 2013 Hyper-methylated miR-203 dysregulates ABL1 and contributes to the nickel-induced tumorigenesis. Nickel 66-72 microRNA 203a Homo sapiens 17-24 24379247-2 2013 We found that copper, nickel, zinc and cobalt complexes with GnRH stimulated the release of LH and FSH both in vivo and in vitro. Nickel 22-28 gonadotropin releasing hormone 1 Homo sapiens 61-65 24238670-13 2013 CONCLUSIONS: NS3 and NS5A were over-expressed and using Nickel-affinity method both proteins were purified to ~ 95% purity. Nickel 56-62 KRAS proto-oncogene, GTPase Homo sapiens 13-16 24148431-0 2013 Label-free fluorescent detection of thrombin activity based on a recombinant enhanced green fluorescence protein and nickel ions immobilized nitrilotriacetic acid-coated magnetic nanoparticles. Nickel 117-123 coagulation factor II, thrombin Homo sapiens 36-44 23968727-5 2013 Meanwhile, we observed hypermethylation of CpGs in miR-203 promoter and first exon area, and proved that the hyper-methylated miR-203 was involved in the Nickel-induced tumorigenesis. Nickel 154-160 microRNA 203a Homo sapiens 51-58 23968727-5 2013 Meanwhile, we observed hypermethylation of CpGs in miR-203 promoter and first exon area, and proved that the hyper-methylated miR-203 was involved in the Nickel-induced tumorigenesis. Nickel 154-160 microRNA 203a Homo sapiens 126-133 23892322-10 2013 Cobalt and nickel ions damage DNA at 5 and 10 muM, respectively. Nickel 11-17 latexin Homo sapiens 46-49 23881359-0 2013 Study on the interaction between a water-soluble dinuclear nickel complex and bovine serum albumin by spectroscopic techniques. Nickel 59-65 albumin Homo sapiens 85-98 23735342-7 2013 The ACM rates in TRILOGY ACS (409/4663) were only 0.017/day or 6.2% annually after clopidogrel, suggesting that the risk to die in the control PLATO-NIS group was 63% higher and barely missed significance (p=0.051) compared to TRILOGY ACS. Nickel 149-152 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 25-28 23821222-6 2013 In contrast, the range of gastric phase BAF for nickel was greater (1.4-43.8 %), while no significant correlation was observed between bioaccessible and total nickel concentrations. Nickel 48-54 BAF nuclear assembly factor 1 Homo sapiens 40-43 23947824-15 2013 We fit the gCP scheme for a recently developed pob-TZVP solid-state basis set and obtain reasonable results for the X23 benchmark set and the potential energy curve for water adsorption on a nickel (110) surface. Nickel 191-197 golgin B1 Homo sapiens 11-14 23928305-11 2013 We demonstrate the nickel-initiated effects are dependent on LSD1-SFMBT1-mediated chromatin modification. Nickel 19-25 lysine demethylase 1A Homo sapiens 61-65 24060497-4 2013 ZNF706 protein was expressed according to the E. coli expression system procedures and was purified using a nickel-affinity column. Nickel 108-114 zinc finger protein 706 Homo sapiens 0-6 23928305-11 2013 We demonstrate the nickel-initiated effects are dependent on LSD1-SFMBT1-mediated chromatin modification. Nickel 19-25 Scm like with four mbt domains 1 Homo sapiens 66-72 24004143-0 2013 Intramolecular d10-d10 interactions in a Ni6C(CO)9(AuPPh3)4 bimetallic nickel-gold carbide carbonyl cluster. Nickel 71-77 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion Homo sapiens 15-18 24004143-0 2013 Intramolecular d10-d10 interactions in a Ni6C(CO)9(AuPPh3)4 bimetallic nickel-gold carbide carbonyl cluster. Nickel 71-77 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion Homo sapiens 19-22 23839275-2 2013 In order to analyze the metal binding ability of human ZnT3 protein, here we report a potentiometric and solution structural (UV-Vis, CD, EPR, NMR) study of nickel(II), copper(II) and zinc(II) complexes of three peptides mimicking the possible metal binding sequences of this protein. Nickel 157-163 solute carrier family 30 member 3 Homo sapiens 55-59 24023911-1 2013 Thyroid iodide uptake through the sodium-iodide symporter (NIS) is not only an essential step for thyroid hormones biosynthesis, but also fundamental for the diagnosis and treatment of different thyroid diseases. Nickel 59-62 solute carrier family 5 member 5 Rattus norvegicus 34-57 23828460-9 2013 Forced overexpression of Bcl-2, Bcl-xL and catalase proteins reduced NiCl2-induced cell death; siRNA-mediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance. Nickel 164-170 BCL2 apoptosis regulator Homo sapiens 25-30 23899293-2 2013 The two accessory proteins HypA and HypB interact with each other and are thought to cooperate to insert nickel into the active site of the hydrogenase-3 precursor protein. Nickel 105-111 hypA Escherichia coli 27-31 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 46-52 hypA Escherichia coli 41-45 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 46-52 hypA Escherichia coli 104-108 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 46-52 hypA Escherichia coli 104-108 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 132-138 hypA Escherichia coli 41-45 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 132-138 hypA Escherichia coli 104-108 23899293-5 2013 This work lead to a re-evaluation of the HypA nickel affinity, revealing a KD on the order of 10(-8) M. HypA can efficiently remove nickel, but not zinc, from the metal-binding site in the GTPase domain of HypB, a process that is less efficient when complex formation between HypA and HypB is disrupted. Nickel 132-138 hypA Escherichia coli 104-108 23899293-6 2013 Furthermore, nickel release from HypB to HypA is specifically accelerated when HypB is loaded with GDP, but not GTP. Nickel 13-19 hypA Escherichia coli 41-45 23899293-7 2013 These results are consistent with the HypA-HypB complex serving as a transfer step in the relay of nickel from membrane transporter to its final destination in the hydrogenase active site and suggest that this complex contributes to the metal fidelity of this pathway. Nickel 99-105 hypA Escherichia coli 38-42 23828460-9 2013 Forced overexpression of Bcl-2, Bcl-xL and catalase proteins reduced NiCl2-induced cell death; siRNA-mediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance. Nickel 164-170 catalase Homo sapiens 43-51 23828460-9 2013 Forced overexpression of Bcl-2, Bcl-xL and catalase proteins reduced NiCl2-induced cell death; siRNA-mediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance. Nickel 164-170 BCL2 apoptosis regulator Homo sapiens 206-211 23828460-9 2013 Forced overexpression of Bcl-2, Bcl-xL and catalase proteins reduced NiCl2-induced cell death; siRNA-mediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance. Nickel 164-170 BCL2 like 1 Homo sapiens 213-219 23828460-9 2013 Forced overexpression of Bcl-2, Bcl-xL and catalase proteins reduced NiCl2-induced cell death; siRNA-mediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance. Nickel 164-170 catalase Homo sapiens 224-232 23727075-8 2013 Meanwhile, the activity of prototypical iron-sulfur clusters (ISCs) containing enzymes that are known to control aerobic metabolism, including complex I and aconitase, and the expression of ISC assembly scaffold protein (ISCU) were inhibited following nickel deposition. Nickel 252-258 iron-sulfur cluster assembly enzyme Mus musculus 221-225 23828170-8 2013 ACTB, HSP90AA1, HSPA5 and HSPA8, which are key mediators of pathways related to apoptosis, proliferation and neoplastic processes, were key mediators of the same pathways in low-dose nickel and cadmium exposure in particular. Nickel 183-189 actin beta Homo sapiens 0-4 23828170-8 2013 ACTB, HSP90AA1, HSPA5 and HSPA8, which are key mediators of pathways related to apoptosis, proliferation and neoplastic processes, were key mediators of the same pathways in low-dose nickel and cadmium exposure in particular. Nickel 183-189 heat shock protein 90 alpha family class A member 1 Homo sapiens 6-14 23828170-8 2013 ACTB, HSP90AA1, HSPA5 and HSPA8, which are key mediators of pathways related to apoptosis, proliferation and neoplastic processes, were key mediators of the same pathways in low-dose nickel and cadmium exposure in particular. Nickel 183-189 heat shock protein family A (Hsp70) member 5 Homo sapiens 16-21 23828170-8 2013 ACTB, HSP90AA1, HSPA5 and HSPA8, which are key mediators of pathways related to apoptosis, proliferation and neoplastic processes, were key mediators of the same pathways in low-dose nickel and cadmium exposure in particular. Nickel 183-189 heat shock protein family A (Hsp70) member 8 Homo sapiens 26-31 23828170-10 2013 We found that HSP90AA1, one of the main modulators, interacted with HIF1A, AR and BCL2 in nickel-exposed cells. Nickel 90-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-22 23828170-10 2013 We found that HSP90AA1, one of the main modulators, interacted with HIF1A, AR and BCL2 in nickel-exposed cells. Nickel 90-96 hypoxia inducible factor 1 subunit alpha Homo sapiens 68-73 23828170-10 2013 We found that HSP90AA1, one of the main modulators, interacted with HIF1A, AR and BCL2 in nickel-exposed cells. Nickel 90-96 BCL2 apoptosis regulator Homo sapiens 82-86 23828170-11 2013 Interestingly, we found that HSP90AA1 was involved in the BCL2-associated apoptotic pathway in the nickel-only data, whereas this gene interacted with several genes functioning in CASP-associated apoptotic signaling in the cadmium-only data. Nickel 99-105 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-37 23828170-11 2013 Interestingly, we found that HSP90AA1 was involved in the BCL2-associated apoptotic pathway in the nickel-only data, whereas this gene interacted with several genes functioning in CASP-associated apoptotic signaling in the cadmium-only data. Nickel 99-105 BCL2 apoptosis regulator Homo sapiens 58-62 23828170-12 2013 Additionally, JUN and FASN were main modulators in nickel-responsive signaling pathways. Nickel 51-57 fatty acid synthase Homo sapiens 22-26 23624239-6 2013 After exposure to increasing concentrations of nickel and cinnamic aldehyde, the expression level of PD-L1 and DCIR revealed much stronger affected on monocyte-derived DCs (MoDCs) or Langerhans cells (MoLCs) when compared to THP-1 and MUTZ-3 cells. Nickel 47-53 CD274 molecule Homo sapiens 101-106 23624239-6 2013 After exposure to increasing concentrations of nickel and cinnamic aldehyde, the expression level of PD-L1 and DCIR revealed much stronger affected on monocyte-derived DCs (MoDCs) or Langerhans cells (MoLCs) when compared to THP-1 and MUTZ-3 cells. Nickel 47-53 C-type lectin domain family 4 member A Homo sapiens 111-115 23624239-6 2013 After exposure to increasing concentrations of nickel and cinnamic aldehyde, the expression level of PD-L1 and DCIR revealed much stronger affected on monocyte-derived DCs (MoDCs) or Langerhans cells (MoLCs) when compared to THP-1 and MUTZ-3 cells. Nickel 47-53 GLI family zinc finger 2 Homo sapiens 225-230 23685052-3 2013 His-tagged galectin-3 was bound to nickel chelate acceptor beads, whereas biotinylated asialofetuin (biotin-ASF), a galectin-3 nanomolar binding partner, was bound to streptavidin-coated donor beads. Nickel 35-41 galectin 3 Homo sapiens 11-21 23906261-2 2013 Dehydrobromination of the precursor (PC(sp)(3)P)NiBr in the presence of a donor (PPh3 or NC(t)Bu) leads to the title complexes, which feature a rare nickel-carbene linkage as the pincer ligand anchor point. Nickel 149-155 protein phosphatase 4 catalytic subunit Homo sapiens 81-85 23598885-0 2013 Fabrication of NiS modified CdS nanorod p-n junction photocatalysts with enhanced visible-light photocatalytic H2-production activity. Nickel 15-18 CDP-diacylglycerol synthase 1 Homo sapiens 28-31 23598885-2 2013 In this study, novel NiS nanoparticle (NP) modified CdS nanorod (NR) p-n junction photocatalysts were prepared by a simple two-step hydrothermal method. Nickel 21-24 CDP-diacylglycerol synthase 1 Homo sapiens 52-55 23598885-3 2013 Even without the Pt co-catalyst, the as-prepared NiS NP-CdS NR samples exhibited enhanced visible-light photocatalytic activity and good stability for H2-production. Nickel 49-52 CDP-diacylglycerol synthase 1 Homo sapiens 56-59 23598885-4 2013 The optimal NiS loading content was determined to be 5 mol%, and the corresponding H2-production rate reached 1131 mumol h(-1) g(-1), which is even higher than that of the optimized Pt-CdS NRs. Nickel 12-15 CDP-diacylglycerol synthase 1 Homo sapiens 185-188 23794416-3 2013 CNF coating was controlled by the reaction time and the nickel content. Nickel 56-62 NPHS1 adhesion molecule, nephrin Homo sapiens 0-3 23722534-1 2013 A detailed surface investigation of the lithium-excess nickel manganese layered oxide Li1.2Ni0.2Mn0.6O2 structure was carried out using X-ray photoelectron spectroscopy (XPS), total electron yield and transmission X-ray absorption spectroscopy (XAS), and electron energy loss spectroscopy (EELS) during the first two electrochemical cycles. Nickel 55-61 transglutaminase 1 Homo sapiens 86-89 23843567-2 2013 In the current study, we used the sodium iodide symporter (NIS) as a theranostic gene to investigate whether coating of adenovirus with synthetic dendrimers could be useful to overcome these hurdles in order to develop adenoviral vectors for combination of systemic oncolytic virotherapy and NIS-mediated radiotherapy. Nickel 59-62 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 34-57 23946853-1 2013 Synthetic studies on the antibiotic natural product ripostatin A have been carried out with the aim to construct the C9-C10 bond by a nickel(0)-catalyzed coupling reaction of an enyne and an epoxide, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. Nickel 134-140 homeobox C10 Homo sapiens 120-123 23773208-7 2013 Because of the presence of nickel impurities, the optical properties of InN have been significantly improved. Nickel 27-33 growth hormone releasing hormone Homo sapiens 72-75 23844176-2 2013 Nickel compounds are well established human carcinogens, however, little is known about the influence of nickel on the spontaneous secretion of IL-8 in oral squamous cell carcinoma (OSCC) cells. Nickel 105-111 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 23526216-0 2013 Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. Nickel 158-164 hypoxia inducible factor 1 subunit alpha Homo sapiens 8-49 23526216-0 2013 Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. Nickel 158-164 C-X-C motif chemokine ligand 8 Homo sapiens 120-133 23526216-2 2013 We have previously shown that soluble nickel (Ni), a common component of PM, alters the release of CXC chemokines from cultured human lung fibroblasts (HLF) in response to microbial stimuli via a pathway dependent on disrupted prostaglandin (PG)E2 signaling. Nickel 38-44 HLF transcription factor, PAR bZIP family member Homo sapiens 152-155 23510276-2 2013 In this study, the capsid protein VP2 of GPV was expressed in Escherichia coli and purified by nickel chromatography. Nickel 95-101 VP2 Goose parvovirus 34-37 23543430-5 2013 BACE1 was coupled to nickel-chelate acceptor beads. Nickel 21-27 beta-secretase 1 Homo sapiens 0-5 23678037-3 2013 OBJECTIVE: Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is overexpressed in multiple cancers and significantly decreases NIS expression at the PM. Nickel 140-143 PTTG1 interacting protein Homo sapiens 11-59 23678037-3 2013 OBJECTIVE: Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is overexpressed in multiple cancers and significantly decreases NIS expression at the PM. Nickel 140-143 PTTG1 interacting protein Homo sapiens 61-64 23678037-3 2013 OBJECTIVE: Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is overexpressed in multiple cancers and significantly decreases NIS expression at the PM. Nickel 140-143 PTTG1 interacting protein Homo sapiens 66-73 23678037-9 2013 Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells. Nickel 110-113 inorganic pyrophosphatase 1 Homo sapiens 66-69 23678037-9 2013 Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells. Nickel 110-113 two pore segment channel 1 Homo sapiens 117-121 23594881-9 2013 Moreover, Notch1 silencing by siRNA decreased resveratrol-induced NIS expression. Nickel 66-69 notch receptor 1 Homo sapiens 10-16 23849174-2 2013 We have now evaluated NIS-expressing oncolytic measles virus (MV-NIS) combined with NIS-guided radioiodide, EBRT and specific checkpoint kinase 1 (Chk1) inhibition in head and neck and colorectal models. Nickel 22-25 checkpoint kinase 1 Homo sapiens 147-151 23692052-0 2013 Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy. Nickel 33-39 lysine demethylase 4A Homo sapiens 90-95 23750476-7 2013 After purification by nickel-affinity and refolding, this scFv antibody (Ab) was proven to recognize hBNP specifically and sensitively in ELISA and dot-blotting assay. Nickel 22-28 immunglobulin heavy chain variable region Homo sapiens 58-62 23564008-0 2013 The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration. Nickel 72-78 C-X-C motif chemokine ligand 8 Homo sapiens 22-26 23564008-0 2013 The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration. Nickel 72-78 interleukin 6 Homo sapiens 31-35 23692033-1 2013 BACKGROUND: Nickel was recently identified as a potent activator of dendritic cells through ligating with human Toll-like receptor (TLR)-4. Nickel 12-18 toll like receptor 4 Homo sapiens 112-138 23692033-7 2013 The critical role of TLR4 in nickel-induced, cobalt-induced and palladium-induced activation was confirmed by essentially similar stimulatory patterns obtained in an HEK293 TLR4/MD2 transfectant cell line. Nickel 29-35 toll like receptor 4 Homo sapiens 21-25 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 CD4 molecule Homo sapiens 0-3 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 interleukin 17A Homo sapiens 25-44 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 interleukin 22 Homo sapiens 46-51 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 interferon gamma Homo sapiens 56-72 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 CD4 molecule Homo sapiens 82-85 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 interleukin 17A Homo sapiens 107-112 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 interleukin 22 Homo sapiens 114-119 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 interferon gamma Homo sapiens 124-133 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 CD4 molecule Homo sapiens 12-15 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 interleukin 17A Homo sapiens 37-42 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 interleukin 22 Homo sapiens 44-49 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 interferon gamma Homo sapiens 54-63 23771053-4 2013 The computational analysis revealed over a thousand non-homologous HrC proteins with a large portion exhibiting interaction with transition metals, particularly zinc, copper and nickel. Nickel 178-184 histidine rich calcium binding protein Homo sapiens 67-70 23750476-7 2013 After purification by nickel-affinity and refolding, this scFv antibody (Ab) was proven to recognize hBNP specifically and sensitively in ELISA and dot-blotting assay. Nickel 22-28 natriuretic peptide B Homo sapiens 101-105 23645109-5 2013 In device characterization, surface profile of the fabricated device is measured using a Veeco surface profilometer; and mean and gradient residual stress in the nickel structure are calculated as approximately 94.7 MPa and -5.27 MPa/mum, respectively. Nickel 162-168 latexin Homo sapiens 234-237 23695573-2 2013 In this study, the full lumenal domain of Erv41p from Saccharomyces cerevisiae (ScErv41p_LD) was recombinantly expressed in Sf9 insect cells and purified by nickel-affinity, ion-exchange and size-exclusion chromatography. Nickel 157-163 Erv41p Saccharomyces cerevisiae S288C 42-48 23447020-0 2013 The alteration of miR-222 and its target genes in nickel-induced tumor. Nickel 50-56 microRNA 222 Homo sapiens 18-25 23447020-6 2013 As we expected, the expression levels of target genes of miR-222, CDKN1B and CDKN1C, were downregulated in the nickel-induced tumor. Nickel 111-117 microRNA 222 Homo sapiens 57-64 23447020-6 2013 As we expected, the expression levels of target genes of miR-222, CDKN1B and CDKN1C, were downregulated in the nickel-induced tumor. Nickel 111-117 cyclin dependent kinase inhibitor 1B Homo sapiens 66-72 23447020-6 2013 As we expected, the expression levels of target genes of miR-222, CDKN1B and CDKN1C, were downregulated in the nickel-induced tumor. Nickel 111-117 cyclin dependent kinase inhibitor 1C Homo sapiens 77-83 23447020-8 2013 We conclude that miR-222 may promote cell proliferation infinitely during nickel-induced tumorigenesis in part by regulating the expression of its target genes CDKN1B and CDKN1C. Nickel 74-80 microRNA 222 Homo sapiens 17-24 23447020-8 2013 We conclude that miR-222 may promote cell proliferation infinitely during nickel-induced tumorigenesis in part by regulating the expression of its target genes CDKN1B and CDKN1C. Nickel 74-80 cyclin dependent kinase inhibitor 1B Homo sapiens 160-166 23447020-8 2013 We conclude that miR-222 may promote cell proliferation infinitely during nickel-induced tumorigenesis in part by regulating the expression of its target genes CDKN1B and CDKN1C. Nickel 74-80 cyclin dependent kinase inhibitor 1C Homo sapiens 171-177 23478149-12 2013 In nickel, gold, and iridium, PBE (for nickel) or LDA (for gold and iridium) remain the best functionals among these four possibilities. Nickel 3-9 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 30-33 23343419-1 2013 BACKGROUND: Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of contact sensitization to allergens other than nickel is also elevated in FLG mutation carriers. Nickel 137-143 filaggrin Homo sapiens 34-43 23343419-1 2013 BACKGROUND: Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of contact sensitization to allergens other than nickel is also elevated in FLG mutation carriers. Nickel 137-143 filaggrin Homo sapiens 50-53 23343419-6 2013 CONCLUSION: FLG mutation carriers with self-reported dermatitis have an increased risk of contact sensitization to substances other than nickel, whereas FLG mutations alone may not, or may only slightly, increase the risk of sensitization. Nickel 137-143 filaggrin Homo sapiens 12-15 23638002-6 2013 Further examination indicated that nickel released from 316L SS triggered the cell apoptosis via Fas-Caspase8-Caspase3 exogenous pathway. Nickel 35-41 caspase 8 Homo sapiens 101-109 23638002-6 2013 Further examination indicated that nickel released from 316L SS triggered the cell apoptosis via Fas-Caspase8-Caspase3 exogenous pathway. Nickel 35-41 caspase 3 Homo sapiens 110-118 23541028-0 2013 Formation of [Ni(III)(kappa(1)-S2CH)(P(o-C6H3-3-SiMe3-2-S)3)]- via CS2 insertion into nickel(III) hydride containing [Ni(III)(H)(P(o-C6H3-3-SiMe3-2-S)3)]-. Nickel 86-92 chorionic somatomammotropin hormone 2 Homo sapiens 67-70 23478149-12 2013 In nickel, gold, and iridium, PBE (for nickel) or LDA (for gold and iridium) remain the best functionals among these four possibilities. Nickel 39-45 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 30-33 23545657-2 2013 The kinase domain of SAD-1 from C. elegans was overexpressed in Escherichia coli BL21 (DE3) cells and purified to homogeneity using nickel-nitrilotriacetic acid metal-affinity, ion-exchange and gel-filtration chromatography. Nickel 132-138 Serine/threonine kinase SAD-1 Caenorhabditis elegans 21-26 23136956-6 2013 RESULTS: In individuals without ear piercings, a higher prevalence of nickel sensitization was found in those with the minor allele of CLDN1 SNP rs9290927 (P(trend)=0 013). Nickel 70-76 claudin 1 Homo sapiens 135-140 23136956-11 2013 CONCLUSIONS: The CLDN1 polymorphisms rs9290927, rs893051 and rs17501010 were associated, respectively, with nickel contact sensitization in individuals without ear piercings, contact sensitization to fragrances, and with both organic compounds and nickel contact dermatitis. Nickel 108-114 claudin 1 Homo sapiens 17-22 23136956-11 2013 CONCLUSIONS: The CLDN1 polymorphisms rs9290927, rs893051 and rs17501010 were associated, respectively, with nickel contact sensitization in individuals without ear piercings, contact sensitization to fragrances, and with both organic compounds and nickel contact dermatitis. Nickel 248-254 claudin 1 Homo sapiens 17-22 23914598-10 2013 Scientific evidence now agree that nickel and certain nickel compounds are toxic and highly harmful to human health they indeed cause allergic contact dermatitis (DAC). Nickel 35-41 arylacetamide deacetylase Homo sapiens 163-166 23914598-10 2013 Scientific evidence now agree that nickel and certain nickel compounds are toxic and highly harmful to human health they indeed cause allergic contact dermatitis (DAC). Nickel 54-60 arylacetamide deacetylase Homo sapiens 163-166 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 NK2 homeobox 1 Mus musculus 51-57 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 transcription termination factor, RNA polymerase I Mus musculus 75-80 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 paired box 8 Mus musculus 86-103 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 paired box 8 Mus musculus 105-109 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroid stimulating hormone receptor Mus musculus 287-291 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroglobulin Mus musculus 294-307 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroglobulin Mus musculus 309-311 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroid peroxidase Mus musculus 318-336 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroid peroxidase Mus musculus 338-341 23404856-5 2013 In this study, we investigated NIS regulation in breast cancer by MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) signaling, an important cell signaling pathway involved in oncogenic transformation. Nickel 31-34 mitogen-activated protein kinase 1 Homo sapiens 66-70 23404856-5 2013 In this study, we investigated NIS regulation in breast cancer by MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) signaling, an important cell signaling pathway involved in oncogenic transformation. Nickel 31-34 mitogen-activated protein kinase 1 Homo sapiens 110-113 23404856-5 2013 In this study, we investigated NIS regulation in breast cancer by MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) signaling, an important cell signaling pathway involved in oncogenic transformation. Nickel 31-34 mitogen-activated protein kinase kinase 7 Homo sapiens 123-126 23404856-6 2013 We found that MEK inhibition decreased NIS protein levels in all-trans retinoic acid/hydrocortisone-treated MCF-7 cells as well as human breast cancer cells expressing exogenous NIS. Nickel 39-42 mitogen-activated protein kinase kinase 7 Homo sapiens 14-17 23404856-6 2013 We found that MEK inhibition decreased NIS protein levels in all-trans retinoic acid/hydrocortisone-treated MCF-7 cells as well as human breast cancer cells expressing exogenous NIS. Nickel 178-181 mitogen-activated protein kinase kinase 7 Homo sapiens 14-17 23404856-7 2013 The decrease in NIS protein levels by MEK inhibition was not accompanied by a decrease in NIS mRNA or a decrease in NIS mRNA export from the nucleus to the cytoplasm. Nickel 16-19 mitogen-activated protein kinase kinase 7 Homo sapiens 38-41 23404856-9 2013 Interestingly, NIS protein level was correlated with MEK/ERK activation in human breast tumors from a tissue microarray. Nickel 15-18 mitogen-activated protein kinase kinase 7 Homo sapiens 53-56 23404856-9 2013 Interestingly, NIS protein level was correlated with MEK/ERK activation in human breast tumors from a tissue microarray. Nickel 15-18 mitogen-activated protein kinase 1 Homo sapiens 57-60 23404856-10 2013 Taken together, MEK activation appears to play an important role in maintaining NIS protein stability in human breast cancers. Nickel 80-83 mitogen-activated protein kinase kinase 7 Homo sapiens 16-19 23362190-1 2013 Three new trinuclear nickel (II) complexes with the general composition [Ni3 L3 (OH)(X)](ClO4 ) have been prepared in which X=Cl(-) (1), OCN(-) (2), or N3(-) (3) and HL is the tridentate N,N,O donor Schiff base ligand 2-[(3-dimethylaminopropylimino)methyl]phenol. Nickel 21-27 bone gamma-carboxyglutamate protein Homo sapiens 137-140 23223606-1 2013 Nickel complexes with hydrotris(pyrazolyl)borate ( = Tp(R)) ligands catalyze alkane oxidation with organic peroxide meta-Cl-C(6)H(4)C([double bond, length as m-dash]O)OOH ( = mCPBA). Nickel 0-6 translocated promoter region, nuclear basket protein Homo sapiens 53-58 32260803-1 2013 Nickel and cobalt are both known to stimulate the hypoxia-inducible factor-1 (HIF-1alpha), thus significantly improving blood vessel formation in tissue engineering applications. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 78-88 23376720-0 2013 Nickel inhibits beta-1 adrenoceptor mediated activation of cardiac CFTR chloride channels. Nickel 0-6 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 67-71 23402366-4 2013 Using a human hepatocellular cancer (HCC) xenograft mouse model (Huh7), we investigated distribution and tumor recruitment of RANTES-NIS-engineered MSCs after systemic injection by gamma camera imaging. Nickel 133-136 chemokine (C-C motif) ligand 5 Mus musculus 126-132 23402366-7 2013 Administration of a therapeutic dose of (131)I or (188)Re (55.5 MBq) in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved survival without significant differences between (131)I and (188)Re. Nickel 79-82 chemokine (C-C motif) ligand 5 Mus musculus 72-78 23402366-8 2013 These data demonstrate successful stromal targeting of NIS in HCC tumors by selective recruitment of NIS-expressing MSCs and by use of the RANTES/CCL5 promoter. Nickel 55-58 chemokine (C-C motif) ligand 5 Mus musculus 139-145 23402366-8 2013 These data demonstrate successful stromal targeting of NIS in HCC tumors by selective recruitment of NIS-expressing MSCs and by use of the RANTES/CCL5 promoter. Nickel 55-58 chemokine (C-C motif) ligand 5 Mus musculus 146-150 23322089-0 2013 Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase. Nickel 25-31 acyl-CoA synthetase short chain family member 2 Homo sapiens 98-124 23322089-1 2013 Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O(2)( -) disproportionation, and exhibit impressive Ni-SOD activity. Nickel 86-92 acyl-CoA synthetase short chain family member 2 Homo sapiens 10-36 23322089-1 2013 Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O(2)( -) disproportionation, and exhibit impressive Ni-SOD activity. Nickel 86-92 acyl-CoA synthetase short chain family member 2 Homo sapiens 38-41 23317420-0 2013 Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway. Nickel 37-43 thymoma viral proto-oncogene 1 Mus musculus 99-102 23317420-9 2013 Exploration of the underlying mechanisms of sesamin action revealed that activities of caspase-3 were markedly inhibited by the treatment of sesamin in the liver of nickel-treated mice. Nickel 165-171 caspase 3 Mus musculus 87-96 23317420-10 2013 Sesamin increased expression levels of phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PBK/Akt) in liver, which in turn inactivated pro-apoptotic signaling events, restoring the balance between pro- and anti-apoptotic Bcl-2 proteins in the liver of nickel-treated mice. Nickel 271-277 PDZ binding kinase Mus musculus 109-112 23317420-10 2013 Sesamin increased expression levels of phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PBK/Akt) in liver, which in turn inactivated pro-apoptotic signaling events, restoring the balance between pro- and anti-apoptotic Bcl-2 proteins in the liver of nickel-treated mice. Nickel 271-277 thymoma viral proto-oncogene 1 Mus musculus 113-116 23317420-11 2013 In conclusion, these results suggested that the inhibition of nickel-induced apoptosis by sesamin is due at least in part to its antioxidant activity and its ability to modulate the PI3K-Akt signaling pathway. Nickel 62-68 thymoma viral proto-oncogene 1 Mus musculus 187-190 23142754-3 2013 Significantly more nickel was released from the nickel metal powder with a thin surface oxide predominantly composed of non-stoichiometric nickel oxide (probably Ni(2)O(3)), compared to the release from the nickel metal powder with a thicker surface oxide predominantly composed of NiO and to a lesser extent Ni(2)O(3) (88% and 25% release after 24 h in ALF, respectively). Nickel 19-25 afamin Homo sapiens 354-357 23216645-3 2013 In the present study, we expressed functional Pho89 in the cell membrane of Pichia pastoris, solubilized it in Triton X-100 and foscholine-12, and purified it by immobilized nickel affinity chromatography combined with size exclusion chromatography. Nickel 174-180 Pho89p Saccharomyces cerevisiae S288C 46-51 22865832-3 2013 In the present study, we designed a biomacromolecular layer-by-layer coating with heparin, vascular endothelial growth factor (VEGF), and fibronectin onto nickel-free titanium surface to improve blood compatibility and endothelial cell proliferation. Nickel 155-161 vascular endothelial growth factor A Homo sapiens 91-125 22865832-3 2013 In the present study, we designed a biomacromolecular layer-by-layer coating with heparin, vascular endothelial growth factor (VEGF), and fibronectin onto nickel-free titanium surface to improve blood compatibility and endothelial cell proliferation. Nickel 155-161 fibronectin 1 Homo sapiens 138-149 23289643-0 2013 Cross-coupling of ArX with ArMgBr catalyzed by N-heterocyclic carbene-based nickel complexes. Nickel 76-82 aristaless related homeobox Homo sapiens 18-21 23281195-0 2013 Enantioselective nickel-catalyzed hydrocyanation of vinylarenes using chiral phosphine-phosphite ligands and TMS-CN as a source of HCN. Nickel 17-23 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 131-134 22410783-8 2013 Epimutational silencing of p16 is the primary event associated with immortalization by nickel, a human non-genotoxic carcinogen. Nickel 87-93 cyclin dependent kinase inhibitor 2A Homo sapiens 27-30 22883109-2 2013 During methanogenesis, methyl coenzyme M (MeCoM) is reduced by MeCoM reductase enzyme to CH(4) involving a nickel-containing cofactor F(430). Nickel 107-113 MDS1 and EVI1 complex locus Homo sapiens 42-47 22883109-2 2013 During methanogenesis, methyl coenzyme M (MeCoM) is reduced by MeCoM reductase enzyme to CH(4) involving a nickel-containing cofactor F(430). Nickel 107-113 MDS1 and EVI1 complex locus Homo sapiens 63-68 23924466-7 2013 RESULTS: TPO ectodomain was recovered from the culture media as a soluble protein, and it was fused with a hexahistidine tag which allowed purification by nickel-affinity chromatography. Nickel 155-161 thyroid peroxidase Homo sapiens 9-12 22762130-1 2013 Nickel is used in coins because the metal has beneficial properties, including price, colour, weight, and corrosion resistance, and also because it is easy to stamp. Nickel 0-6 tubulin tyrosine ligase like 5 Homo sapiens 159-164 23762181-4 2013 An eight-channel ball-type electrode array is fabricated with an embedded titanium-nickel SMA backbone wire. Nickel 83-89 survival of motor neuron 1, telomeric Homo sapiens 90-93 23104555-2 2012 The reaction with Ni(COD)(2) led to a diamagnetic dinuclear nickel(I) complex (4) which was also obtained by the reaction of the square planar Ni(II) complexes [(PNP-Ph(2))NiX] (X = Cl (2), X = I (3)) with Li(Et(3)BH). Nickel 60-66 BCL2 interacting protein 3 like Homo sapiens 172-175 22982218-0 2013 The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines. Nickel 48-51 poly(ADP-ribose) polymerase 1 Homo sapiens 4-8 22982218-1 2013 Since PARP-1 is supposed to be part of a multimeric repressor of sodium iodide symporter (NIS) expression, in this study the effect of the PARP inhibitor PJ34 on several properties of thyroid cancer cell lines was investigated. Nickel 90-93 poly(ADP-ribose) polymerase 1 Homo sapiens 6-12 22982218-5 2013 We also investigated the epigenetic status of NIS promoter after PJ34 treatment in TPC1 cell line: in addition to an increase of histone modification activation marks (H3K9K14ac, H3K4me3), surprisingly we observed also an increase of H3K27me3, a classical repressive mark. Nickel 46-49 two pore segment channel 1 Homo sapiens 83-87 22982218-6 2013 Our data demonstrate that in various thyroid cancer cell lines PARP inhibition increases NIS gene expression through a particular modulation of transcriptional regulatory mechanisms. Nickel 89-92 poly(ADP-ribose) polymerase 1 Homo sapiens 63-67 25428090-1 2013 Nickel-Titanium shape memory alloys (NiTi-SMA) are of biomedical interest due to their unusual range of pure elastic deformability and their elastic modulus, which is closer to that of bone than any other metallic or ceramic material. Nickel 0-6 survival of motor neuron 1, telomeric Homo sapiens 42-45 23536762-0 2013 GADD45alpha induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Calpha expression. Nickel 25-31 growth arrest and DNA-damage-inducible 45 alpha Mus musculus 0-11 23536762-0 2013 GADD45alpha induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Calpha expression. Nickel 25-31 mitogen-activated protein kinase 14 Mus musculus 58-61 23536762-0 2013 GADD45alpha induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Calpha expression. Nickel 25-31 protein phosphatase 1A, magnesium dependent, alpha isoform Mus musculus 87-96 23536762-3 2013 However, we found here that the depletion of GADD45alpha (GADD45alpha-/-) in mouse embryonic fibroblasts (MEFs) resulted in an increase in the phosphorylation of MKK4/7, MKK3/6 and consequently specific up-regulated the activation of JNK/p38 and their downstream transcription factors, such as c-Jun and ATF2, in comparison to those in GADD45alpha+/+ MEFs cell following nickel exposure. Nickel 371-377 growth arrest and DNA-damage-inducible 45 alpha Mus musculus 45-56 23536762-3 2013 However, we found here that the depletion of GADD45alpha (GADD45alpha-/-) in mouse embryonic fibroblasts (MEFs) resulted in an increase in the phosphorylation of MKK4/7, MKK3/6 and consequently specific up-regulated the activation of JNK/p38 and their downstream transcription factors, such as c-Jun and ATF2, in comparison to those in GADD45alpha+/+ MEFs cell following nickel exposure. Nickel 371-377 growth arrest and DNA-damage-inducible 45 alpha Mus musculus 58-69 23536762-3 2013 However, we found here that the depletion of GADD45alpha (GADD45alpha-/-) in mouse embryonic fibroblasts (MEFs) resulted in an increase in the phosphorylation of MKK4/7, MKK3/6 and consequently specific up-regulated the activation of JNK/p38 and their downstream transcription factors, such as c-Jun and ATF2, in comparison to those in GADD45alpha+/+ MEFs cell following nickel exposure. Nickel 371-377 mitogen-activated protein kinase kinase 4 Mus musculus 162-168 23536762-3 2013 However, we found here that the depletion of GADD45alpha (GADD45alpha-/-) in mouse embryonic fibroblasts (MEFs) resulted in an increase in the phosphorylation of MKK4/7, MKK3/6 and consequently specific up-regulated the activation of JNK/p38 and their downstream transcription factors, such as c-Jun and ATF2, in comparison to those in GADD45alpha+/+ MEFs cell following nickel exposure. Nickel 371-377 growth arrest and DNA-damage-inducible 45 alpha Mus musculus 58-69 23129151-1 2012 Active in alkaline environment: The activity of nickel, silver, and copper catalysts for the electrochemical transformation of water to molecular hydrogen in alkaline solutions was enhanced by modification of the metal surfaces by Ni(OH)(2) (see picture; I = current density and eta = overpotential). Nickel 48-54 endothelin receptor type A Homo sapiens 214-217 23228661-0 2012 WITHDRAWN: Overexpression of a C(2)H(2)-type zinc finger protein gene, ZAT11, leads to enhanced primary root growth and increased nickel ion sensitivity in Arabidopsis. Nickel 130-136 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 71-76 22644664-6 2012 Average nickel level changed from 9.75 +- 5.02 to 10.37 +- 6.94 and then to 8.32 +- 4.36 mug/L in 1 year. Nickel 8-14 CD2 cytoplasmic tail binding protein 2 Homo sapiens 93-99 22577760-7 2012 Building and related trades workers showed positive reactions to chromium + nickel [odds ratio (OR) 1.99; 95% confidence interval (CI) 1.05-3.76) and chromium + cobalt (OR 2.61; 95% CI 1.46-4.67]. Nickel 76-82 olfactory receptor family 7 subfamily E member 16 pseudogene Homo sapiens 84-104 22928956-8 2012 Bivariate analyses pointed to significantly increased nickel excretion with increasing age, ingestion of dietary supplements, drinking of stagnant tap water, and consumption of nickel-rich food. Nickel 54-60 nuclear RNA export factor 1 Homo sapiens 147-150 23059983-0 2012 Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. Nickel 16-22 toll like receptor 4 Homo sapiens 45-49 23216160-0 2012 NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination. Nickel 113-119 NLR family, pyrin domain containing 3 Mus musculus 0-5 22967084-0 2012 Reduction in clonogenic survival of sodium-iodide symporter (NIS)-positive cells following intracellular uptake of (99m)Tc versus (188)Re. Nickel 61-64 solute carrier family 5 member 5 Rattus norvegicus 36-59 23447969-2 2012 It was found nanostar nickel revealed the Ni(111) crystallographic plane with particle size in the range of 150-200 nm and BET surface area of 13 m2/g. Nickel 22-28 delta/notch like EGF repeat containing Homo sapiens 123-126 23447969-3 2012 The icosahedra nickel also showed the Ni(111) crystallographic plane with larger particle size (300-400 nm) and BET surface area of 20 m2/g, whereas microsphere nickel exhibited the relatively large cluster size (approximately 3 microm) and BET surface area (114 m2/g) as a result of an aggregation of Ni(101) nanoplates. Nickel 15-21 delta/notch like EGF repeat containing Homo sapiens 112-115 22847264-2 2012 With mammalian cells, we show that ATP13A2 expression protects against manganese and nickel toxicity, in addition to proteasomal, mitochondrial, and oxidative stress. Nickel 85-91 ATPase cation transporting 13A2 Homo sapiens 35-42 22972152-1 2012 Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. Nickel 194-200 N-myc downstream regulated 1 Homo sapiens 6-39 22972152-1 2012 Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. Nickel 194-200 N-myc downstream regulated 1 Homo sapiens 41-46 23072436-2 2012 Three protonated isomers are formed (endo/endo, endo/exo, or exo/exo), which differ in the position of the N-H bond"s with respect to nickel. Nickel 134-140 mannosidase endo-alpha Homo sapiens 37-41 23072436-2 2012 Three protonated isomers are formed (endo/endo, endo/exo, or exo/exo), which differ in the position of the N-H bond"s with respect to nickel. Nickel 134-140 mannosidase endo-alpha Homo sapiens 42-46 23072436-2 2012 Three protonated isomers are formed (endo/endo, endo/exo, or exo/exo), which differ in the position of the N-H bond"s with respect to nickel. Nickel 134-140 mannosidase endo-alpha Homo sapiens 42-46 23072436-3 2012 The endo/endo isomer is the most productive isomer due to the two protons being sufficiently close to the nickel to proceed readily to the transition state to form/cleave H(2). Nickel 106-112 mannosidase endo-alpha Homo sapiens 4-8 23072436-3 2012 The endo/endo isomer is the most productive isomer due to the two protons being sufficiently close to the nickel to proceed readily to the transition state to form/cleave H(2). Nickel 106-112 mannosidase endo-alpha Homo sapiens 9-13 22930274-6 2012 Zinc, but not ibotenic acid, caused upregulation of a nickel-sensitive I(CaT) in a subset of contralateral CA1 pyramidal cells, appearing 2 days after injection and lasting for about 2 weeks thereafter. Nickel 54-60 carbonic anhydrase 1 Rattus norvegicus 107-110 23091041-0 2012 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Nickel 59-65 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-15 23091041-0 2012 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Nickel 59-65 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 17-20 23091041-0 2012 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Nickel 86-92 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-15 23091041-0 2012 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Nickel 86-92 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 17-20 22270236-6 2012 The rDGAT2 in the soluble fraction was partially purified by amylose resin, nickel-nitrilotriacetic agarose (Ni-NTA) beads, and tandem affinity chromatography. Nickel 76-82 diacylglycerol O-acyltransferase 2 Rattus norvegicus 4-10 22583413-3 2012 Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 90-97 22583413-3 2012 Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 180-187 22962269-0 2012 Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG. Nickel 19-22 Rho guanine nucleotide exchange factor 12 Homo sapiens 134-138 22962269-3 2012 In this study, we investigated the functional role in tumor progression of the sodium/iodide symporter (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas. Nickel 104-107 solute carrier family 5 member 5 Homo sapiens 113-119 23090023-4 2012 Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its nickel complex. Nickel 90-96 tensin 1 Rattus norvegicus 78-81 22910906-3 2012 In this study, it was found that a deficiency of JNK2 expression reduced HIF-1alpha protein induction in response to nickel treatment resulting from the impaired expression of hif-1alpha mRNA. Nickel 117-123 mitogen-activated protein kinase 9 Homo sapiens 49-53 22910906-3 2012 In this study, it was found that a deficiency of JNK2 expression reduced HIF-1alpha protein induction in response to nickel treatment resulting from the impaired expression of hif-1alpha mRNA. Nickel 117-123 hypoxia inducible factor 1 subunit alpha Homo sapiens 73-83 22910906-3 2012 In this study, it was found that a deficiency of JNK2 expression reduced HIF-1alpha protein induction in response to nickel treatment resulting from the impaired expression of hif-1alpha mRNA. Nickel 117-123 hypoxia inducible factor 1 subunit alpha Homo sapiens 176-186 22700867-4 2012 In this study, we discovered that PDGF synergistically enhanced nickel NP (NiNP)-induced increases in mRNA and protein levels of the profibrogenic chemokine monocyte chemoattractant protein-1 (MCP-1 or CCL2), and the antifibrogenic IFN-inducible CXC chemokine (CXCL10) in normal rat pleural mesothelial 2 (NRM2) cells in vitro. Nickel 64-70 C-C motif chemokine ligand 2 Rattus norvegicus 193-198 22700867-4 2012 In this study, we discovered that PDGF synergistically enhanced nickel NP (NiNP)-induced increases in mRNA and protein levels of the profibrogenic chemokine monocyte chemoattractant protein-1 (MCP-1 or CCL2), and the antifibrogenic IFN-inducible CXC chemokine (CXCL10) in normal rat pleural mesothelial 2 (NRM2) cells in vitro. Nickel 64-70 C-C motif chemokine ligand 2 Rattus norvegicus 202-206 22988853-12 2012 It also plays other roles in plant metabolism such as protecting GAPDH from inactivation and scavenging metal ions such as copper and nickel, and it is also linked to stress responses. Nickel 134-140 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-70 23127505-2 2012 For this purpose combination of Fos (a product of the immediate early gene) labeling with nickel intensified diaminobenzidine (DAB-Ni) and two neuropeptides labeled with Alexa488 and Alexa555 fluorescent dyes on cryo-processed 35-40 microm thick free-floating brain sections was selected. Nickel 90-96 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-35 22700867-4 2012 In this study, we discovered that PDGF synergistically enhanced nickel NP (NiNP)-induced increases in mRNA and protein levels of the profibrogenic chemokine monocyte chemoattractant protein-1 (MCP-1 or CCL2), and the antifibrogenic IFN-inducible CXC chemokine (CXCL10) in normal rat pleural mesothelial 2 (NRM2) cells in vitro. Nickel 64-70 C-X-C motif chemokine ligand 10 Rattus norvegicus 261-267 24061321-4 2012 Under the optimal conditions, the calibration curve was linear within the range of 5-180 microg L-1 of nickel with R2 = 0.9960. Nickel 103-109 immunoglobulin kappa variable 1-16 Homo sapiens 96-99 24061321-5 2012 Limit of detection (3Sb/m) was 0.6 microg L-1 in the original solution and the relative standard deviation for ten replicate determination of 100 microg L-1 nickel was 2.9%. Nickel 157-163 immunoglobulin kappa variable 1-16 Homo sapiens 153-156 23198410-4 2012 Furthermore, the interacting protein of daintain/AIF-1 was purified by daintain/AIF-1-6 histidine antigen fusion protein nickel affinity chromatography. Nickel 121-127 allograft inflammatory factor 1 Homo sapiens 49-54 23198410-4 2012 Furthermore, the interacting protein of daintain/AIF-1 was purified by daintain/AIF-1-6 histidine antigen fusion protein nickel affinity chromatography. Nickel 121-127 allograft inflammatory factor 1 Homo sapiens 80-87 22402732-5 2012 Under optimum conditions, the new system allowed an enrichment factor of 29.80 to be obtained after 60 min of experiment, and it was successfully applied to the determination of nickel in both saline and non-saline water samples, at ppb and ppt levels. Nickel 178-184 tachykinin precursor 1 Homo sapiens 241-244 22682327-2 2012 5%, 9% and 12%) with the aim to study the influence of the metal incorporation method and the nickel loading in the catalytic activity of gas-phase hydrogenation of 2-tert-butylphenol (2-TBP). Nickel 94-100 TATA-box binding protein Homo sapiens 187-190 22682327-5 2012 Catalytic results revealed that the nickel particle size and support properties affected directly to both the catalytic activity of hydrogenation of 2-TBP, and the rate of secondary reactions such as cis to trans isomerization and 2-tert-butylcyclohexanone (2-TBCN) hydrogenation. Nickel 36-42 TATA-box binding protein Homo sapiens 151-154 22636422-7 2012 A pass through a nickel chelating column removed any histidine-tagged residual fusion protein, leaving highly pure apoA-II. Nickel 17-23 apolipoprotein A2 Homo sapiens 115-122 22695972-0 2012 C-Cl bond activation of ortho-chlorinated benzamides by nickel and cobalt compounds supported with phosphine ligands. Nickel 56-62 crystallin gamma C Homo sapiens 0-4 22695972-1 2012 The C-Cl bonds of ortho-chlorinated benzamides Cl-ortho-C(6)H(4)C(=O)NHR (R = Me (1), nBu (2), Ph (3), (4-Me)Ph (4) and (4-Cl)Ph (5)) were successfully activated by tetrakis(trimethylphosphine)nickel(0) and tetrakis(trimethylphosphine)cobalt(0). Nickel 193-199 crystallin gamma C Homo sapiens 4-8 22767659-2 2012 In this study, sodium iodide symporter (NIS) transgene imaging was evaluated as an approach to follow in vivo survival, engraftment, and distribution of human-induced pluripotent stem cell (hiPSC) derivatives in a pig model of myocardial infarction. Nickel 40-43 solute carrier family 5 member 5 Sus scrofa 15-38 22535767-2 2012 The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland. Nickel 29-32 solute carrier family 16 (monocarboxylic acid transporters), member 2 Mus musculus 116-145 22648416-0 2012 Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. Nickel 0-6 cadherin 1 Homo sapiens 91-101 26588967-2 2012 This work presents a detailed analysis of the physical origin of the zero-field splittings (ZFSs) in a series of high-spin (S = 1) nickel(II) scorpionate complexes Tp*NiX (Tp* = hydrotris(3,5-dimethylpyrazole)borate, X = Cl, Br, I) using quantum chemical approaches. Nickel 131-137 BCL2 interacting protein 3 like Homo sapiens 167-170 22708922-0 2012 Heteropolytopic arsanylarylthiolato ligands: cis-trans isomerism of nickel(II), palladium(II), and platinum(II) complexes of 1-AsPh2-2-SHC6H4. Nickel 68-74 aspartate beta-hydroxylase Homo sapiens 127-131 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Nickel 197-200 transcription termination factor 1 Homo sapiens 53-59 22535767-2 2012 The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland. Nickel 29-32 solute carrier family 16 (monocarboxylic acid transporters), member 2 Mus musculus 147-151 22535767-3 2012 Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is a protooncogene that is up-regulated in thyroid cancer and that binds NIS and modulates its subcellular localization and function. Nickel 137-140 pituitary tumor-transforming 1 interacting protein Mus musculus 0-48 22535767-3 2012 Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is a protooncogene that is up-regulated in thyroid cancer and that binds NIS and modulates its subcellular localization and function. Nickel 137-140 pituitary tumor-transforming 1 interacting protein Mus musculus 50-53 22535767-3 2012 Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is a protooncogene that is up-regulated in thyroid cancer and that binds NIS and modulates its subcellular localization and function. Nickel 137-140 pituitary tumor-transforming 1 interacting protein Mus musculus 55-62 23057330-1 2012 OBJECTIVE: To investigate the level of malondiadehyde (MDA), antisuperoxide anion and inducible nitric oxide synthase (iNOS) in liver of rats poisoned by nickel carbonyl in order to discuss the mechanism of acute nickel carbonyl poisoning. Nickel 154-160 nitric oxide synthase 2 Rattus norvegicus 86-117 23057330-1 2012 OBJECTIVE: To investigate the level of malondiadehyde (MDA), antisuperoxide anion and inducible nitric oxide synthase (iNOS) in liver of rats poisoned by nickel carbonyl in order to discuss the mechanism of acute nickel carbonyl poisoning. Nickel 154-160 nitric oxide synthase 2 Rattus norvegicus 119-123 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Nickel 197-200 paired box 8 Homo sapiens 64-69 22498723-8 2012 The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma. Nickel 59-62 transcription termination factor 1 Homo sapiens 22-27 22498723-8 2012 The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma. Nickel 59-62 paired box 8 Homo sapiens 32-37 22538316-4 2012 The G6PD cDNA was cloned and expressed into Escherichia coli as a fusion protein and was purified in a single chromatographic step using nickel affinity gel column. Nickel 137-143 glucose-6-phosphate 1-dehydrogenase Camelus dromedarius 4-8 22542587-8 2012 By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS. Nickel 62-68 ATPase family AAA domain containing 3A Homo sapiens 30-36 22542587-8 2012 By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS. Nickel 62-68 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 22473518-1 2012 The present paper reports the first comprehensive study on the synthesis, structures, optical and electrochemical properties, and peripheral functionalizations of nickel(II) and copper(II) complexes of beta-unsubstituted 5,15-diazaporphyrins (M-DAP; M = Ni, Cu) and pyridazine-fused diazacorrinoids (Ni-DACX; X = N, O). Nickel 163-169 death associated protein Homo sapiens 245-248 22571318-12 2012 Nickel nanoparticles (NiNPs), which are present in MWCNTs as a residual catalyst, also induced COX-2 via ERK-1,2. Nickel 0-6 prostaglandin-endoperoxide synthase 2 Mus musculus 95-100 22571318-12 2012 Nickel nanoparticles (NiNPs), which are present in MWCNTs as a residual catalyst, also induced COX-2 via ERK-1,2. Nickel 0-6 mitogen-activated protein kinase 3 Mus musculus 105-112 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Nickel 62-68 matrix metallopeptidase 2 Homo sapiens 137-142 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Nickel 62-68 interleukin 1 beta Homo sapiens 144-152 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Nickel 62-68 interleukin 6 Homo sapiens 157-161 22301953-7 2012 Hep3B cells expressing TERT specific NIS (Hep3B-TERT/NIS) were xenografted into nude mouse and visualized with micro-SPECT/CT for monitoring NIS activity. Nickel 37-40 telomerase reverse transcriptase Homo sapiens 23-27 21814724-8 2012 NELL1 protein was purified from culture medium using a one-step nickel-chelate affinity chromatography protocol. Nickel 64-70 neural EGFL like 1 Homo sapiens 0-5 22517932-0 2012 Allergy risk from Royal Mint"s new nickel plated steel coins should be publicly assessed. Nickel 35-41 spen family transcriptional repressor Homo sapiens 24-28 22318714-0 2012 Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. Nickel 22-28 lysine demethylase 3A Homo sapiens 45-51 22172649-0 2012 A novel tyrosinase biosensor based on chitosan-carbon-coated nickel nanocomposite film. Nickel 61-67 tyrosinase Homo sapiens 8-18 22301953-7 2012 Hep3B cells expressing TERT specific NIS (Hep3B-TERT/NIS) were xenografted into nude mouse and visualized with micro-SPECT/CT for monitoring NIS activity. Nickel 37-40 telomerase reverse transcriptase Homo sapiens 48-52 22301953-7 2012 Hep3B cells expressing TERT specific NIS (Hep3B-TERT/NIS) were xenografted into nude mouse and visualized with micro-SPECT/CT for monitoring NIS activity. Nickel 53-56 telomerase reverse transcriptase Homo sapiens 23-27 22301953-7 2012 Hep3B cells expressing TERT specific NIS (Hep3B-TERT/NIS) were xenografted into nude mouse and visualized with micro-SPECT/CT for monitoring NIS activity. Nickel 53-56 telomerase reverse transcriptase Homo sapiens 23-27 22154009-0 2012 The effect of VEGF-immobilized nickel-free high-nitrogen stainless steel on viability and proliferation of vascular endothelial cells. Nickel 31-37 vascular endothelial growth factor A Homo sapiens 14-18 22154009-1 2012 Using ester bonds, vascular endothelial growth factor-A (VEGF-A) was immobilized on the surface of a novel biometal, nickel-free high-nitrogen stainless steel (HNS). Nickel 117-123 vascular endothelial growth factor A Homo sapiens 19-55 22154009-1 2012 Using ester bonds, vascular endothelial growth factor-A (VEGF-A) was immobilized on the surface of a novel biometal, nickel-free high-nitrogen stainless steel (HNS). Nickel 117-123 vascular endothelial growth factor A Homo sapiens 57-63 22467388-4 2012 The open reading frame of hTFF2 was inserted into a pET-32a(+) expression vector, and hTFF2-TRX fusion protein was successfully expressed in Escherichia coli and purified by Nickel-nitrilotriacetic acid affinity chromatography and reverse-phase HPLC steps. Nickel 174-180 trefoil factor 2 Homo sapiens 26-31 21833035-1 2012 The thyroid transcription factor Pax-8 could bind with the promoter/enhancer of thyroid-specific genes such as thyroglobulin (Tg), thyroperoxidase (TPO) and sodium iodide symporter (NIS), and regulate the expression of these proteins in thyrocyte. Nickel 182-185 paired box 8 Homo sapiens 33-38 22400908-1 2012 Divalent and trivalent nickel complexes of 1,4,8,11-tetraazacyclotetradecane, denoted as cyclam hereafter, coordinated by methyl coenzyme M (MeSCoM(-)) and coenzyme M (HSCoM(-)) have been synthesized in the course our model studies of methyl coenzyme M reductase (MCR). Nickel 23-29 nuclear receptor subfamily 3 group C member 2 Homo sapiens 264-267 22333739-5 2012 Based on these data, four nickel compounds would receive a Category 4 acute toxicity classification according to the European Regulation on Classification, Labelling and Packaging of Chemical Substances and Mixtures (CLP), while the rest of the nickel substances tested fit the criterion for no classification. Nickel 26-32 calmodulin like 3 Homo sapiens 217-220 22116111-8 2012 RESULTS: The 2001-2008 NIS contained 181,200 CEA and 12,485 CAS procedures. Nickel 23-26 CEA cell adhesion molecule 3 Homo sapiens 45-48 22116111-8 2012 RESULTS: The 2001-2008 NIS contained 181,200 CEA and 12,485 CAS procedures. Nickel 23-26 BCAR1 scaffold protein, Cas family member Homo sapiens 60-63 23569901-12 2012 Perhaps oxidation of L-ascorbic acid to L-dehydro ascorbic acid via the free radical (HSc*) generation from the reaction of H2ASc + Ni (II) is the cause of such alteration of lambdamax value of L-ascorbic acid in the presence of metal nickel. Nickel 235-241 fucosyltransferase 1 (H blood group) Homo sapiens 86-90 22285091-9 2012 Nickel exposure via drinking water was derived from databases on Ni tap water quality. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 68-71 22236398-0 2012 Blocking of CTLA-4 on lymphocytes improves the sensitivity of lymphocyte transformation tests in a patient with nickel allergy. Nickel 112-118 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 12-18 22476458-0 2012 Induction of IRT1 by the nickel-induced iron-deficient response in Arabidopsis. Nickel 25-31 iron-regulated transporter 1 Arabidopsis thaliana 13-17 22179615-7 2012 PCFT monomers with hemagglutinin and His(10) epitope tags were co-expressed in R1-11 cells, solubilized, and bound to nickel affinity columns, establishing their physical associations. Nickel 118-124 solute carrier family 46 member 1 Homo sapiens 0-4 22242765-8 2012 The results from our experiments have demonstrated that zinc, copper(II), and nickel can be transported by hZIP4 when the cation concentration is in the micromolar range. Nickel 78-84 solute carrier family 39 member 4 Homo sapiens 107-112 22157753-4 2012 To identify a signal transduction pathway that selectively stimulates NIS expression, we investigated regulation by the Rac1-p38 signaling pathway in MCF-7 breast cancer cells and compared it with regulation in FRTL-5 rat thyroid cells. Nickel 70-73 Rac family small GTPase 1 Homo sapiens 120-124 22125203-1 2012 Diamond-like carbon (DLC) coatings were deposited on nearly equiatomic nickel-titanium (NiTi) alloy by arc-enhanced magnetron sputtering. Nickel 71-77 roadblock Drosophila melanogaster 0-19 22055767-2 2012 The unconstrained lattice misfit in a single-crystal of the MC2 nickel-based superalloy is determined using convergent beam electron diffraction measurements and finite element calculations. Nickel 64-70 melanocortin 5 receptor Homo sapiens 60-63 22157753-5 2012 Loss of function experiments with pharmacologic inhibitors and small interfering RNA, as well as RT-PCR analysis of p38 isoforms, demonstrated the requirement of Rac1, MAPK kinase 3B, and p38beta for the full expression of NIS in MCF-7 cells. Nickel 223-226 Rac family small GTPase 1 Homo sapiens 162-166 22157753-5 2012 Loss of function experiments with pharmacologic inhibitors and small interfering RNA, as well as RT-PCR analysis of p38 isoforms, demonstrated the requirement of Rac1, MAPK kinase 3B, and p38beta for the full expression of NIS in MCF-7 cells. Nickel 223-226 mitogen-activated protein kinase 11 Homo sapiens 188-195 22157753-6 2012 In contrast, p38alpha was critical for NIS expression in FRTL-5 cells. Nickel 39-42 mitogen activated protein kinase 14 Rattus norvegicus 13-21 22157753-9 2012 Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. Nickel 111-114 mitogen-activated protein kinase 11 Homo sapiens 18-25 22157753-9 2012 Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. Nickel 111-114 Rac family small GTPase 1 Homo sapiens 29-33 22157753-10 2012 This study demonstrates differential regulation of NIS by distinct p38 isoforms in breast cancer cells and thyroid cells. Nickel 51-54 mitogen-activated protein kinase 14 Homo sapiens 67-70 22157753-11 2012 Targeting isoform-selective activation of p38 may enhance NIS induction, resulting in higher efficacy of (131)I concentration and treatment of breast cancer. Nickel 58-61 mitogen-activated protein kinase 14 Homo sapiens 42-45 21994264-5 2012 In transverse slice preparations from transgenic Hb9::enhanced green fluorescent protein neonatal mice, N-methyl-d-aspartate-induced membrane potential oscillations in identified Hb9 interneurons also slowed in frequency with application of nickel when fast, spike-mediated, synaptic transmission was blocked with TTX. Nickel 241-247 motor neuron and pancreas homeobox 1 Mus musculus 49-52 21994264-5 2012 In transverse slice preparations from transgenic Hb9::enhanced green fluorescent protein neonatal mice, N-methyl-d-aspartate-induced membrane potential oscillations in identified Hb9 interneurons also slowed in frequency with application of nickel when fast, spike-mediated, synaptic transmission was blocked with TTX. Nickel 241-247 motor neuron and pancreas homeobox 1 Mus musculus 179-182 22791051-8 2012 Minimal inhibitory concentration (MIC) of 1,024 microg mL-1 was observed for copper (100%) and nickel (71.4%). Nickel 95-101 L1 cell adhesion molecule Mus musculus 55-59 22328822-5 2012 Recombinant LOXL1 variant proteins were purified by nickel-affinity chromatography. Nickel 52-58 lysyl oxidase like 1 Homo sapiens 12-17 22359623-1 2012 BACKGROUND: This study was designed to explore the therapeutic potential of suppressing MAP kinase and PI3K/Akt pathways and histone deacetylase (HDAC) to induce the expression of sodium/iodide symporter (NIS) and radioiodine uptake in non-thyroid cancer cells. Nickel 205-208 AKT serine/threonine kinase 1 Homo sapiens 108-111 23163107-5 2012 Moreover, the BRAF(V600E) mutation was associated with a statistically significant lower functional NIS protein expression in the classic variant of papillary thyroid carcinomas. Nickel 100-103 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 14-19 23163107-7 2012 CONCLUSIONS: The BRAF(V600E) mutation might be associated with a more aggressive phenotype and a poor prognosis, causing less NIS-mediated 131I uptake due to a lower functional NIS protein expression in the classic variant of papillary thyroid carcinomas. Nickel 126-129 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 17-22 23163107-7 2012 CONCLUSIONS: The BRAF(V600E) mutation might be associated with a more aggressive phenotype and a poor prognosis, causing less NIS-mediated 131I uptake due to a lower functional NIS protein expression in the classic variant of papillary thyroid carcinomas. Nickel 177-180 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 17-22 23119075-9 2012 IMAC of purified TGF-beta1 and the latency associated peptide showed that these proteins bound to the immobilized nickel ions. Nickel 114-120 transforming growth factor beta 1 Homo sapiens 17-26 23119075-9 2012 IMAC of purified TGF-beta1 and the latency associated peptide showed that these proteins bound to the immobilized nickel ions. Nickel 114-120 transforming growth factor beta 1 Homo sapiens 35-61 23119075-10 2012 These data clearly demonstrate that TGF-beta1 was co-purified by specific interactions with nickel, and not by specific interactions with fibrillin-1 fragments. Nickel 92-98 transforming growth factor beta 1 Homo sapiens 36-45 23056446-7 2012 If nickel was used as a stimulus, blockage of PD-L1 led to high amounts of TNF-alpha and IL-22. Nickel 3-9 CD274 molecule Homo sapiens 46-51 23056446-7 2012 If nickel was used as a stimulus, blockage of PD-L1 led to high amounts of TNF-alpha and IL-22. Nickel 3-9 tumor necrosis factor Homo sapiens 75-84 23056446-7 2012 If nickel was used as a stimulus, blockage of PD-L1 led to high amounts of TNF-alpha and IL-22. Nickel 3-9 interleukin 22 Homo sapiens 89-94 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 CD274 molecule Homo sapiens 24-29 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 interferon gamma Homo sapiens 136-145 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 interleukin 17A Homo sapiens 150-155 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 C-C motif chemokine receptor 6 Homo sapiens 171-175 22768177-10 2012 Finally, ATP13A2 overexpression sensitizes cortical neurons to neurite shortening induced by exposure to cadmium or nickel ions, supporting a functional interaction between ATP13A2 and heavy metals in post-mitotic neurons, whereas missense mutations influence this sensitizing effect. Nickel 116-122 ATPase cation transporting 13A2 Homo sapiens 9-16 22719903-4 2012 METHODS AND FINDINGS: TSC2-deficient human cells, derived from the angiomyolipoma of a LAM patient, were engineered to co-express both sodium-iodide symporter (NIS) and green fluorescent protein (GFP). Nickel 160-163 TSC complex subunit 2 Homo sapiens 22-26 22384275-2 2012 Metal chaperone proteins HypA and HypB are required for the nickel insertion step of [NiFe]-hydrogenase maturation. Nickel 60-66 hypA Escherichia coli 25-29 22384275-3 2012 How HypA and HypB work together to deliver nickel to the catalytic core remains elusive. Nickel 43-49 hypA Escherichia coli 4-8 22359623-2 2012 METHODS: We tested the effects of the MEK inhibitor RDEA119, the Akt inhibitor perifosine, and the HDAC inhibitor SAHA on NIS expression in thirteen human cancer cell lines derived from melanoma, hepatic carcinoma, gastric carcinoma, colon carcinoma, breast carcinoma, and brain cancers. Nickel 122-125 mitogen-activated protein kinase kinase 7 Homo sapiens 38-41 22384275-10 2012 The HypA binding site is in proximity to the metal binding site of HypB, suggesting that the HypA/HypB interaction may facilitate nickel transfer between the two proteins. Nickel 130-136 hypA Escherichia coli 4-8 22384275-10 2012 The HypA binding site is in proximity to the metal binding site of HypB, suggesting that the HypA/HypB interaction may facilitate nickel transfer between the two proteins. Nickel 130-136 hypA Escherichia coli 93-97 22359623-8 2012 CONCLUSIONS: This is the first demonstration that simultaneously suppressing the MAP kinase and PI3K/Akt pathways and HDAC could induce robust NIS expression and radioiodine uptake in certain non-thyroid human cancer cells, providing novel therapeutic implications for adjunct radioiodine treatment of these cancers. Nickel 143-146 AKT serine/threonine kinase 1 Homo sapiens 101-104 22016389-0 2011 Protein interactions and localization of the Escherichia coli accessory protein HypA during nickel insertion to [NiFe] hydrogenase. Nickel 92-98 hypA Escherichia coli 80-84 22016389-1 2011 Nickel delivery during maturation of Escherichia coli [NiFe] hydrogenase 3 includes the accessory proteins HypA, HypB, and SlyD. Nickel 0-6 hypA Escherichia coli 107-111 22016389-4 2011 Multiprotein complexes containing HypA, HypB, SlyD, and HycE were observed, consistent with the assembly of a single nickel insertion cluster. Nickel 117-123 hypA Escherichia coli 34-38 22016389-6 2011 The HypA-HycE complex was not detected in the absence of the HypC or HypD proteins, involved in the preceding iron insertion step, and this interaction is enhanced by nickel brought into the cell by the NikABCDE membrane transporter. Nickel 167-173 hypA Escherichia coli 4-8 22016389-8 2011 These results support the hypothesis that HypA acts as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center. Nickel 86-92 hypA Escherichia coli 42-46 22016389-9 2011 At different stages of the hydrogenase maturation process, HypA was observed at or near the cell membrane by using fluorescence confocal microscopy, as was HycE, suggesting membrane localization of the nickel insertion event. Nickel 202-208 hypA Escherichia coli 59-63 21937214-0 2011 Site-specific immobilization of a (His)6-tagged acetylcholinesterase on nickel nanoparticles for highly sensitive toxicity biosensors. Nickel 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21996445-9 2011 DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression. Nickel 12-18 interleukin 1 alpha Homo sapiens 126-131 21996445-9 2011 DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression. Nickel 12-18 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 22133446-0 2011 Nickel ENMs activate HIF-1alpha. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 21-31 21971347-9 2011 We report that cytosolic XRCC5 is increased in response to Cu, but not zinc, iron, or nickel, and the level of cytosolic XRCC5 correlates with protection against oxidative damage to DNA. Nickel 86-92 X-ray repair cross complementing 5 Homo sapiens 25-30 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Nickel 115-121 solute carrier family 39 member 1 Homo sapiens 36-41 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Nickel 115-121 solute carrier family 39 member 1 Homo sapiens 169-173 21851208-2 2011 The aim of the current study in the same HCC model was to evaluate the potential of biodegradable nanoparticle vectors based on pseudodendritic oligoamines (G2-HD-OEI) for systemic sodium iodide symporter (NIS) gene delivery and to compare efficiency and tumor specificity with LPEI-PEG-GE11. Nickel 206-209 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 181-204 21401309-0 2011 The role of hypoxia inducible factor-1alpha in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nickel 118-124 hypoxia inducible factor 1 subunit alpha Homo sapiens 12-43 21401309-0 2011 The role of hypoxia inducible factor-1alpha in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nickel 118-124 matrix metallopeptidase 2 Homo sapiens 61-66 21401309-0 2011 The role of hypoxia inducible factor-1alpha in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nickel 118-124 matrix metallopeptidase 9 Homo sapiens 71-76 22032412-7 2011 The addition of anisole to 1 also results in the formation of a eta(6) nickel arene complex, [Ni(eta(6)-MeOC(6)H(5))(NO)][PF(6)] (7). Nickel 71-77 endothelin receptor type A Homo sapiens 64-67 22032412-7 2011 The addition of anisole to 1 also results in the formation of a eta(6) nickel arene complex, [Ni(eta(6)-MeOC(6)H(5))(NO)][PF(6)] (7). Nickel 71-77 endothelin receptor type A Homo sapiens 97-100 22639605-10 2011 We summarize previous results and present novel evidence that the four NAS genes have partially overlapping functions when plants are exposed to Fe deficiency and nickel supply. Nickel 163-169 nicotianamine synthase Arabidopsis thaliana 71-74 21449600-0 2011 Theoretical insights into the nature of nickel-carbon dioxide interactions in Ni(PH3)2(eta2-CO2). Nickel 40-46 DNA polymerase iota Homo sapiens 87-91 21837363-0 2011 Activation of Akt/GSK3beta and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. Nickel 63-69 AKT serine/threonine kinase 1 Homo sapiens 31-34 21837363-0 2011 Activation of Akt/GSK3beta and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. Nickel 63-69 BCL2 apoptosis regulator Homo sapiens 35-40 21837363-3 2011 Here, we investigated Akt perturbation in nickel-transformed cells. Nickel 42-48 AKT serine/threonine kinase 1 Homo sapiens 22-25 21837363-5 2011 Western blot assays show that phosphorylation of Akt at Ser473, but not that of p38, JNK and ERK, was increased in nickel-transformed cells compared with controls. Nickel 115-121 AKT serine/threonine kinase 1 Homo sapiens 49-52 21837363-6 2011 Inhibition of Akt or PI3K by pharmacological or biochemical interference suppressed nickel AI growth and cell growth of transformed cells. Nickel 84-90 AKT serine/threonine kinase 1 Homo sapiens 14-17 21837363-7 2011 Activation of Akt led to inhibition of GSK3beta by phosphorylation at Ser9 in nickel-transformed cells. Nickel 78-84 AKT serine/threonine kinase 1 Homo sapiens 14-17 21837363-7 2011 Activation of Akt led to inhibition of GSK3beta by phosphorylation at Ser9 in nickel-transformed cells. Nickel 78-84 glycogen synthase kinase 3 beta Homo sapiens 39-47 21837363-8 2011 In addition, two major anti-apoptotic proteins of the Bcl family, Bcl-2 and Bcl-XL, were increased in nickel-transformed cells. Nickel 102-108 BCL2 apoptosis regulator Homo sapiens 66-71 21837363-8 2011 In addition, two major anti-apoptotic proteins of the Bcl family, Bcl-2 and Bcl-XL, were increased in nickel-transformed cells. Nickel 102-108 BCL2 like 1 Homo sapiens 76-82 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 AKT serine/threonine kinase 1 Homo sapiens 88-91 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 BCL2 apoptosis regulator Homo sapiens 121-126 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 BCL2 like 1 Homo sapiens 131-137 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 BCL2 apoptosis regulator Homo sapiens 196-201 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 BCL2 like 1 Homo sapiens 206-212 21837363-9 2011 By employing the small interfering RNA technique (siRNA), our results showed that siRNA Akt attenuated the expression of Bcl-2 and Bcl-XL in nickel-transformed cells, indicating that induction of Bcl-2 and Bcl-XL was likely mediated through Akt. Nickel 141-147 AKT serine/threonine kinase 1 Homo sapiens 241-244 21837363-12 2011 Taken together, these findings demonstrate that activation of Akt, followed by GSK3beta inhibition and Bcl-2, Bcl-XL up-regulation and decrease of ROS generation, along with a synergistic effect of Rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis. Nickel 290-296 AKT serine/threonine kinase 1 Homo sapiens 62-65 21797922-6 2011 Consistent with this finding, nickel was found to destroy mtDNA nucleoid structure and decrease protein levels of Tfam, a key protein component for nucleoid organization. Nickel 30-36 transcription factor A, mitochondrial Mus musculus 114-118 21842098-0 2011 Zinc, cadmium and nickel increase the activation of NF-kappaB and the release of cytokines from THP-1 monocytic cells. Nickel 18-24 nuclear factor kappa B subunit 1 Homo sapiens 52-61 21842098-0 2011 Zinc, cadmium and nickel increase the activation of NF-kappaB and the release of cytokines from THP-1 monocytic cells. Nickel 18-24 GLI family zinc finger 2 Homo sapiens 96-101 21842098-2 2011 The aim of the present work was to clarify the effect of zinc, nickel and cadmium on NF-kappaB activation in the THP-1 human monocytic leukemia cell line. Nickel 63-69 nuclear factor kappa B subunit 1 Homo sapiens 85-94 21842098-2 2011 The aim of the present work was to clarify the effect of zinc, nickel and cadmium on NF-kappaB activation in the THP-1 human monocytic leukemia cell line. Nickel 63-69 GLI family zinc finger 2 Homo sapiens 113-118 21842098-4 2011 The results obtained demonstrated that zinc, nickel and cadmium significantly activate NF-kappaB, and the release of the chemokine IL-8. Nickel 45-51 nuclear factor kappa B subunit 1 Homo sapiens 87-96 21842098-4 2011 The results obtained demonstrated that zinc, nickel and cadmium significantly activate NF-kappaB, and the release of the chemokine IL-8. Nickel 45-51 C-X-C motif chemokine ligand 8 Homo sapiens 131-135 21603885-7 2011 The nickel form of S. aureus PDF was obtained by adding NiCl(2) to all reagents used for purification. Nickel 4-10 peptide deformylase, mitochondrial Homo sapiens 29-32 21828359-6 2011 In contrast to no response to metallic Ni microparticles, nickel nanoparticles caused a rapid and prolonged activation of the HIF-1alpha pathway that was stronger than that induced by soluble Ni(II). Nickel 58-64 hypoxia inducible factor 1 subunit alpha Homo sapiens 126-136 21837363-0 2011 Activation of Akt/GSK3beta and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. Nickel 63-69 AKT serine/threonine kinase 1 Homo sapiens 14-17 21837363-0 2011 Activation of Akt/GSK3beta and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. Nickel 63-69 glycogen synthase kinase 3 beta Homo sapiens 18-26 21897993-0 2011 Nickel-catalyzed sp2 C-H bonds arylation of N-aromatic heterocycles with Grignard reagents at room temperature. Nickel 0-6 Sp2 transcription factor Homo sapiens 17-20 22044769-5 2011 After purification by nickel affinity chromatography and refolding, the recombinant protein was used to raise the anti-US11 polyclonal antibody. Nickel 22-28 tegument protein US11 Human alphaherpesvirus 1 119-123 21698426-0 2011 Nickel allergies: paying the Toll for innate immunity. Nickel 0-6 toll like receptor 4 Homo sapiens 29-33 21846728-6 2011 These results were consistent with detection of a physical interaction between AC and cysSA, assessed by co-immunoprecipitation and nickel-nitrilotriacetic acid affinity chromatography, and further supported by co-localization of the endogenous proteins using confocal microscopy. Nickel 132-138 cystatin SA Homo sapiens 86-91 21844185-3 2011 Expression of the sodium iodide symporter (NIS), a gene essential to the radioiodine ablation of thyroid hyperplasia, neoplasia, and metastasis, was also potently inhibited in PBF-Tg mice. Nickel 43-46 pituitary tumor-transforming 1 interacting protein Mus musculus 176-179 21707761-3 2011 The purpose of our study was to characterize the expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis (AD) and acute allergic contact dermatitis (ACD) induced in nickel-sensitive individuals. Nickel 203-209 C-C motif chemokine ligand 27 Homo sapiens 63-68 21707761-3 2011 The purpose of our study was to characterize the expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis (AD) and acute allergic contact dermatitis (ACD) induced in nickel-sensitive individuals. Nickel 203-209 C-C motif chemokine ligand 17 Homo sapiens 73-78 21909780-7 2011 A more recent study revealed an association between FLG mutations and increased nickel sensitization, but not other contact allergens. Nickel 80-86 filaggrin Homo sapiens 52-55 22654804-9 2011 Lastly, using immunocytochemistry coupled with nickel backfill, we demonstrated that some ap-GnRH neurons projected to efferent nerves known to innervate the foot and parapodia, suggesting ap-GnRH may directly modulate the motor output of these peripheral tissues. Nickel 47-53 preprogonadotropin-releasing hormone-like protein Aplysia californica 90-97 21826370-4 2011 The crystal structure of 1 has been solved to show the coordination of nickel to the C-C bond of C(70) at the 6-6 ring junction of eta(2)-type to form Ni-C(C(70)) bonds of 1.929-1.941(2) A length, the shortest M-C bonds among those known for eta(2)-complexes of fullerenes C(60) and C(70). Nickel 71-77 DNA polymerase iota Homo sapiens 131-136 21826370-4 2011 The crystal structure of 1 has been solved to show the coordination of nickel to the C-C bond of C(70) at the 6-6 ring junction of eta(2)-type to form Ni-C(C(70)) bonds of 1.929-1.941(2) A length, the shortest M-C bonds among those known for eta(2)-complexes of fullerenes C(60) and C(70). Nickel 71-77 DNA polymerase iota Homo sapiens 242-247 21796325-4 2011 The interaction of Co(II), Ni(II) and Cu(II) with the unsymmetric macrocycle series has been investigated by potentiometric (pH) titration in 95% methanol; X-ray structures of two nickel and three copper complexes of these ligands, each exhibiting 1:1 (M:L) ratios, have been obtained. Nickel 180-186 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-25 21587211-3 2011 In the current study, we stably transfected bone marrow-derived CD34(-) MSCs with NIS cDNA (NIS-MSC), which revealed high levels of functional NIS protein expression. Nickel 82-85 CD34 antigen Mus musculus 64-68 21784563-3 2011 The cytotoxicity data suggest that these compounds may be endowed with important biological properties, especially the nickel complex 2 with MIC = 31.2 mug/mL and IC(50) = 0.53 muM, respectively. Nickel 119-125 latexin Homo sapiens 177-180 21697253-4 2011 DESIGN AND METHODS: Promoter fragments from either hTERT or hTR were used to drive the expression of NIS in cell lines derived from melanoma (M14), breast (MDA-MB-231), colon (HT-29), lung (H460), ovarian (OVCAR-3), and thyroid (TPC-1) carcinomas. Nickel 101-104 telomerase reverse transcriptase Homo sapiens 51-56 21697253-4 2011 DESIGN AND METHODS: Promoter fragments from either hTERT or hTR were used to drive the expression of NIS in cell lines derived from melanoma (M14), breast (MDA-MB-231), colon (HT-29), lung (H460), ovarian (OVCAR-3), and thyroid (TPC-1) carcinomas. Nickel 101-104 telomerase RNA component Homo sapiens 60-63 21741339-12 2011 Therefore, Hst-5 and other histatins should be considered as factors in nickel allergy and other forms of nickel toxicity. Nickel 72-78 histatin 3 Homo sapiens 11-16 21741339-12 2011 Therefore, Hst-5 and other histatins should be considered as factors in nickel allergy and other forms of nickel toxicity. Nickel 106-112 histatin 3 Homo sapiens 11-16 21812053-3 2011 The (His)(7) -PINIT domain (PIAS3(85-272) ) was heterologously expressed and purified to homogeneity by nickel affinity and size exclusion chromatography, and shown to be a folded monomer in solution. Nickel 104-110 protein inhibitor of activated STAT 3 Homo sapiens 28-33 21587211-3 2011 In the current study, we stably transfected bone marrow-derived CD34(-) MSCs with NIS cDNA (NIS-MSC), which revealed high levels of functional NIS protein expression. Nickel 92-95 CD34 antigen Mus musculus 64-68 21587211-3 2011 In the current study, we stably transfected bone marrow-derived CD34(-) MSCs with NIS cDNA (NIS-MSC), which revealed high levels of functional NIS protein expression. Nickel 92-95 CD34 antigen Mus musculus 64-68 21692477-6 2011 An acetate complex demonstrating an eta(1)-OC(O)CH(3) binding mode to nickel has also been synthesized and characterized by single-crystal X-ray crystallography. Nickel 70-76 endothelin receptor type A Homo sapiens 5-8 21678080-5 2011 Iron-overload concentrations impeded the ability of chromium (15.0 muM) or nickel (10.3 muM) to load completely into Tf. Nickel 75-81 latexin Homo sapiens 88-91 21678080-5 2011 Iron-overload concentrations impeded the ability of chromium (15.0 muM) or nickel (10.3 muM) to load completely into Tf. Nickel 75-81 transferrin Homo sapiens 117-119 21678080-8 2011 The initial rates of Fe(3+) loading increased in the presence of nickel or chromium, with maximal Fe(3+) loading into Tf in all cases reaching approximately 24%. Nickel 65-71 transferrin Homo sapiens 118-120 21742768-0 2011 AtIRT1, the primary iron uptake transporter in the root, mediates excess nickel accumulation in Arabidopsis thaliana. Nickel 73-79 iron-regulated transporter 1 Arabidopsis thaliana 0-6 21569788-2 2011 While nickel induces the maturation of dendritic cells via NF-kappaB and p38 MAPK activation, it also exerts immunosuppressive effects on T cells through an unknown mechanism. Nickel 6-12 mitogen-activated protein kinase 14 Homo sapiens 73-76 21402045-4 2011 A biochemical method was developed to measure the kinase activity of PDK1 and AKT1/2, utilizing nickel-chelating coated lipid vesicles as a way to mimic the membrane environment. Nickel 96-102 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial Cricetulus griseus 69-73 21402045-4 2011 A biochemical method was developed to measure the kinase activity of PDK1 and AKT1/2, utilizing nickel-chelating coated lipid vesicles as a way to mimic the membrane environment. Nickel 96-102 RAC-alpha serine/threonine-protein kinase Cricetulus griseus 78-84 21473897-0 2011 Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. Nickel 0-6 toll like receptor 4 Homo sapiens 70-74 21473897-0 2011 Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. Nickel 0-6 MYD88 innate immune signal transduction adaptor Homo sapiens 75-80 21473897-3 2011 In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells. Nickel 38-44 C-X-C motif chemokine ligand 8 Homo sapiens 183-187 21473897-3 2011 In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells. Nickel 38-44 transforming growth factor beta 1 Homo sapiens 189-197 21473897-3 2011 In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells. Nickel 38-44 matrix metallopeptidase 2 Homo sapiens 199-203 21473897-3 2011 In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells. Nickel 38-44 matrix metallopeptidase 9 Homo sapiens 208-212 21473897-4 2011 Importantly, we demonstrated that nickel could activate TLR4 signaling in human lung cancer cells. Nickel 34-40 toll like receptor 4 Homo sapiens 56-60 21473897-5 2011 Further studies showed that the TLR4/MyD88 signaling conferred the enhanced invasive potential of human lung cancer cells induced by nickel. Nickel 133-139 toll like receptor 4 Homo sapiens 32-36 21473897-5 2011 Further studies showed that the TLR4/MyD88 signaling conferred the enhanced invasive potential of human lung cancer cells induced by nickel. Nickel 133-139 MYD88 innate immune signal transduction adaptor Homo sapiens 37-42 21611652-1 2011 Nickel complexes having acetylated glucopyranosyl group incorporated N-heterocyclic carbene (NHC) ligands with methyl or benzyl groups as an N-substituent exhibit two kinds of dynamic behaviours in solution (1)H NMR spectroscopy. Nickel 0-6 high mobility group nucleosomal binding domain 4 Homo sapiens 93-96 21611652-0 2011 Dynamic behaviour attributed to chiral carbohydrate substituents of N-heterocyclic carbene ligands in square planar nickel complexes. Nickel 116-122 high mobility group nucleosomal binding domain 4 Homo sapiens 68-90 21611652-1 2011 Nickel complexes having acetylated glucopyranosyl group incorporated N-heterocyclic carbene (NHC) ligands with methyl or benzyl groups as an N-substituent exhibit two kinds of dynamic behaviours in solution (1)H NMR spectroscopy. Nickel 0-6 high mobility group nucleosomal binding domain 4 Homo sapiens 69-91 21611652-4 2011 Crystallographic analysis of the nickel complex having the NHC ligand with acetylated glucopyranosyl and benzyl groups as N-substituents showed CH-pi interaction between the glucopyranosyl unit of each NHC ligand and the phenyl ring of the other NHC ligand in the complex in the solid state. Nickel 33-39 high mobility group nucleosomal binding domain 4 Homo sapiens 59-62 21611652-4 2011 Crystallographic analysis of the nickel complex having the NHC ligand with acetylated glucopyranosyl and benzyl groups as N-substituents showed CH-pi interaction between the glucopyranosyl unit of each NHC ligand and the phenyl ring of the other NHC ligand in the complex in the solid state. Nickel 33-39 high mobility group nucleosomal binding domain 4 Homo sapiens 202-205 21611652-4 2011 Crystallographic analysis of the nickel complex having the NHC ligand with acetylated glucopyranosyl and benzyl groups as N-substituents showed CH-pi interaction between the glucopyranosyl unit of each NHC ligand and the phenyl ring of the other NHC ligand in the complex in the solid state. Nickel 33-39 high mobility group nucleosomal binding domain 4 Homo sapiens 202-205 21989446-6 2011 In addition, there was a significant positive correlation between NIS and TSHR in benign nodules and normal thyroid samples (r = 0.551 and 0.667, respectively, P = 0.001 and 0.000, respectively) but there was no such correlation in thyroid carcinomas (r = 0.222, P = 0.376). Nickel 66-69 thyroid stimulating hormone receptor Homo sapiens 74-78 21586563-4 2011 When expressed in Escherichia coli, N-27 POR-G3H6 could be purified to apparent homogeneity by a modified, single-step nickel-nitrilotriacetic acid affinity chromatography, yielding 31 mg POR per liter of culture, whereas standard purification of native N-27 POR required multiple steps, yielding 5 mg POR per liter. Nickel 119-125 cytochrome p450 oxidoreductase Homo sapiens 41-44 21721654-0 2011 Spin transport properties of single metallocene molecules attached to single-walled carbon nanotubes via nickel adatoms. Nickel 105-111 spindlin 1 Homo sapiens 0-4 21466819-6 2011 Nickel treatment caused activation of NF-kappaB. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 38-47 21466819-7 2011 Blockage of NF-kappaB partially reversed nickel-induced DeltaNp63 suppression. Nickel 41-47 nuclear factor kappa B subunit 1 Homo sapiens 12-21 21466819-8 2011 Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100. Nickel 0-6 interferon regulatory factor 3 Homo sapiens 17-53 21466819-8 2011 Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100. Nickel 0-6 interferon regulatory factor 7 Homo sapiens 58-62 21466819-8 2011 Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100. Nickel 0-6 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 64-74 21466819-8 2011 Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100. Nickel 0-6 SP100 nuclear antigen Homo sapiens 80-85 21466819-9 2011 Over-expression of IRF3 increased DeltaNp63 expression suppressed by nickel. Nickel 69-75 interferon regulatory factor 3 Homo sapiens 19-23 21466819-10 2011 Nickel was able to activate p21, and its activation was offset by the over-expression of DeltaNp63. Nickel 0-6 H3 histone pseudogene 16 Homo sapiens 28-31 21466819-11 2011 In turn, elevated p63 expression counteracted the ability of nickel to restrict cell growth. Nickel 61-67 tumor protein p63 Homo sapiens 18-21 21466819-12 2011 The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation. Nickel 36-42 interferon regulatory factor 3 Homo sapiens 84-88 21466819-12 2011 The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation. Nickel 36-42 interferon regulatory factor 7 Homo sapiens 93-97 21466819-12 2011 The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation. Nickel 36-42 nuclear factor kappa B subunit 1 Homo sapiens 113-122 21466819-12 2011 The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation. Nickel 36-42 H3 histone pseudogene 16 Homo sapiens 168-171 21486220-0 2011 A cross-talk between NFAT and NF-kappaB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Nickel 64-70 nuclear factor kappa B subunit 1 Homo sapiens 30-39 21539457-5 2011 The recombinant H-protein was secreted into the culture medium and purified to homogeneity using a one-step nickel-nitrilotriacetic acid resin column. Nickel 108-114 myosin binding protein H Homo sapiens 16-25 21486220-0 2011 A cross-talk between NFAT and NF-kappaB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Nickel 64-70 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-84 21486220-2 2011 Our studies have shown that the exposure of Beas-2B cells, a human bronchial epithelial cell line, to lung carcinogenic nickel compounds results in increased COX-2 expression. Nickel 120-126 prostaglandin-endoperoxide synthase 2 Homo sapiens 158-163 21486220-3 2011 However, the signaling pathways leading to nickel-induced COX-2 expression are not well understood. Nickel 43-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-63 21486220-4 2011 In the current study, we found that the exposure of Beas-2B cells to nickel compounds resulted in the activation of both nuclear factor of activated T cell (NFAT) and nuclear factor-kappaB (NF-kappaB). Nickel 69-75 nuclear factor kappa B subunit 1 Homo sapiens 190-199 21486220-5 2011 The expression of COX-2 induced upon nickel exposure was inhibited by either a NFAT pharmacological inhibitor or the knockdown of NFAT3 by specific siRNA. Nickel 37-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 21486220-5 2011 The expression of COX-2 induced upon nickel exposure was inhibited by either a NFAT pharmacological inhibitor or the knockdown of NFAT3 by specific siRNA. Nickel 37-43 nuclear factor of activated T cells 4 Homo sapiens 130-135 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 80-86 nuclear factor kappa B subunit 1 Homo sapiens 43-52 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 80-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 95-100 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 80-86 nuclear factor kappa B subunit 1 Homo sapiens 274-283 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 80-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 292-297 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 nuclear factor kappa B subunit 1 Homo sapiens 43-52 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 prostaglandin-endoperoxide synthase 2 Homo sapiens 95-100 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 nuclear factor kappa B subunit 1 Homo sapiens 274-283 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 prostaglandin-endoperoxide synthase 2 Homo sapiens 292-297 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 nuclear factor kappa B subunit 1 Homo sapiens 43-52 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 prostaglandin-endoperoxide synthase 2 Homo sapiens 95-100 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 nuclear factor kappa B subunit 1 Homo sapiens 274-283 21486220-7 2011 Since our previous studies have shown that NF-kappaB activation is critical for nickel-induced COX-2 expression in Beas-2B cells exposed to nickel compounds under same experimental condition, we anticipate that there might be a cross-talk between the activation of NFAT and NF-kappaB for the COX-2 induction due to nickel exposure in Beas-2B cells. Nickel 140-146 prostaglandin-endoperoxide synthase 2 Homo sapiens 292-297 21486220-8 2011 Furthermore, we showed that the scavenging of reactive oxygen species (ROS) by introduction of mitochondrial catalase inhibited the activation of both NFAT and NF-kappaB, and the induction of COX-2 due to nickel exposure. Nickel 205-211 prostaglandin-endoperoxide synthase 2 Homo sapiens 192-197 21486220-9 2011 Taken together, our results defining the evidence showing a key role of the cross-talk between NFAT and NF-kappaB pathways in regulating nickel-induced COX-2 expression, further provide insight into the understanding of the molecular mechanisms linking nickel exposure to its lung carcinogenic effects. Nickel 137-143 nuclear factor kappa B subunit 1 Homo sapiens 104-113 21486220-9 2011 Taken together, our results defining the evidence showing a key role of the cross-talk between NFAT and NF-kappaB pathways in regulating nickel-induced COX-2 expression, further provide insight into the understanding of the molecular mechanisms linking nickel exposure to its lung carcinogenic effects. Nickel 137-143 prostaglandin-endoperoxide synthase 2 Homo sapiens 152-157 21486220-9 2011 Taken together, our results defining the evidence showing a key role of the cross-talk between NFAT and NF-kappaB pathways in regulating nickel-induced COX-2 expression, further provide insight into the understanding of the molecular mechanisms linking nickel exposure to its lung carcinogenic effects. Nickel 253-259 nuclear factor kappa B subunit 1 Homo sapiens 104-113 21486220-9 2011 Taken together, our results defining the evidence showing a key role of the cross-talk between NFAT and NF-kappaB pathways in regulating nickel-induced COX-2 expression, further provide insight into the understanding of the molecular mechanisms linking nickel exposure to its lung carcinogenic effects. Nickel 253-259 prostaglandin-endoperoxide synthase 2 Homo sapiens 152-157 21796966-5 2011 The levels of alanine aminotransferase and aspartate aminotransferase were significantly higher in nickel-exposed workers. Nickel 99-105 glutamic--pyruvic transaminase Homo sapiens 14-38 21796966-6 2011 The level of serum albumin was significantly negatively correlated and the levels of serum aminotransferases, and serum gamma-glutamyl-transpeptidase were significantly positively correlated with urine nickel levels. Nickel 202-208 inactive glutathione hydrolase 2 Homo sapiens 120-149 21391665-3 2011 Density functional calculations for a model nickel complex, [Ni(MeC(O)NNO(2))(CN)(2)](-), are used to help distinguish the observed IR bands for the four possible conformations and binding geometries of this ligand. Nickel 44-50 C-C motif chemokine ligand 28 Homo sapiens 64-67 21565300-13 2011 Also the concentration of additives SPB and SA-1 along a nickel bath life can be followed using image data handled with algorithms such as partial least squares (PLS) regression and support vector regression (SVR). Nickel 57-63 surfactant protein B Homo sapiens 36-39 21565300-13 2011 Also the concentration of additives SPB and SA-1 along a nickel bath life can be followed using image data handled with algorithms such as partial least squares (PLS) regression and support vector regression (SVR). Nickel 57-63 stromal antigen 1 Homo sapiens 44-48 21414325-1 2011 CnrX is the metal sensor and signal modulator of the three-protein transmembrane signal transduction complex CnrYXH of Cupriavidus metallidurans CH34 that is involved in the setup of cobalt and nickel resistance. Nickel 194-200 periplasmic nickel sensor Cupriavidus metallidurans CH34 0-4 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 tumor protein p53 Homo sapiens 187-190 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 BCL2 associated X, apoptosis regulator Homo sapiens 215-218 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 caspase 3 Homo sapiens 220-229 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 caspase 9 Homo sapiens 234-243 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 BCL2 apoptosis regulator Homo sapiens 342-347 21382431-10 2011 To the best of our knowledge this is the first report showing that nickel ferrite nanoparticles induced apoptosis in A549 cells through ROS generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways. Nickel 67-73 tumor protein p53 Homo sapiens 176-179 21382431-10 2011 To the best of our knowledge this is the first report showing that nickel ferrite nanoparticles induced apoptosis in A549 cells through ROS generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways. Nickel 67-73 BCL2 associated X, apoptosis regulator Homo sapiens 191-194 21382431-10 2011 To the best of our knowledge this is the first report showing that nickel ferrite nanoparticles induced apoptosis in A549 cells through ROS generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways. Nickel 67-73 BCL2 apoptosis regulator Homo sapiens 195-200 21565688-0 2011 Methylation of RAR-beta2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats. Nickel 63-69 cyclin-dependent kinase inhibitor 2A Rattus norvegicus 39-45 21565688-1 2011 OBJECTIVE: To investigate the expression variation of RAR-beta2, RASSF1A, and CDKN2A gene in the process of nickel-induced carcinogenesis. Nickel 108-114 cyclin-dependent kinase inhibitor 2A Rattus norvegicus 78-84 21565688-7 2011 CONCLUSION: These findings suggest that loss of function or decrease of RAR-beta2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5" region of these genes, are related with nickel exposure. Nickel 182-188 cyclin-dependent kinase inhibitor 2A Rattus norvegicus 96-102 21658331-11 2011 Further trials evaluating the effect of a nickel-low diet regimen on lactase activity, histological features and immunological pattern are needed. Nickel 42-48 lactase Homo sapiens 69-76 21178820-6 2011 Using embryonic mouse cultured cardiomyocytes, we showed that both nifedipine and nickel inhibited the ability of NCX to extrude Ca from the cytosol. Nickel 82-88 T cell leukemia, homeobox 2 Mus musculus 114-117 21281641-0 2011 Histidine 416 of the periplasmic binding protein NikA is essential for nickel uptake in Escherichia coli. Nickel 71-77 relaxosome component Escherichia coli 49-53 21544193-0 2011 A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice. Nickel 53-59 mitogen-activated protein kinase kinase 6 Mus musculus 40-44 21455298-5 2011 Nickel exposure increased the level of H3K4 trimethylation in both the promoters and coding regions of several genes including CA9 and NDRG1 that were increased in expression in A549 cells. Nickel 0-6 carbonic anhydrase 9 Homo sapiens 127-130 21455298-5 2011 Nickel exposure increased the level of H3K4 trimethylation in both the promoters and coding regions of several genes including CA9 and NDRG1 that were increased in expression in A549 cells. Nickel 0-6 N-myc downstream regulated 1 Homo sapiens 135-140 21222436-0 2011 Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism. Nickel 0-6 ferrochelatase Mus musculus 59-73 21370341-0 2011 Highly regio- and stereoselective three-component nickel-catalyzed syn-hydrocarboxylation of alkynes with diethyl zinc and carbon dioxide. Nickel 50-56 synemin Homo sapiens 67-70 21488133-4 2011 Using radiolabeled NaB((3) H)H(4) and Raney nickel as well as sulfhydryl assay (Ellman"s reagent), we confirmed that CDA could conjugate with cysteine through a thioether linkage. Nickel 44-50 cytidine deaminase Homo sapiens 117-120 21228305-5 2011 The remainder of the response was blocked by nickel, indicating that T-type (Ca(V)3) LVA calcium channels also contribute. Nickel 45-51 caveolin 3 Homo sapiens 69-83 21455490-10 2011 We demonstrated that haly-1 mutant animals are resistant to nickel toxicity and dietary histidine promotes nickel tolerance in wild-type animals. Nickel 60-66 Histidine ammonia-lyase Caenorhabditis elegans 21-27 21364918-3 2011 Recently, Hes1 was shown to be expressed in the thyroid and regulate expression of the sodium iodide symporter (Nis). Nickel 112-115 hes family bHLH transcription factor 1 Mus musculus 10-14 21281641-6 2011 These results confirm the essential role of His416 in nickel transport by NikA. Nickel 54-60 relaxosome component Escherichia coli 74-78 21210055-0 2011 Redox-active nickel and cobalt tris(pyrazolyl)borate dithiocarbamate complexes: air-stable Co(II) dithiocarbamates. Nickel 13-19 mitochondrially encoded cytochrome c oxidase II Homo sapiens 91-97 21188985-6 2011 Different from the nickel analogue, PdPc(OBu)(8) and PtPc(OBu)(8) show a modest and irregular saddling distortion of the macrocycle, but share with the first member of the group similar UV-vis spectra, with the deep red and intense Q-band absorption experiencing a blue shift down the group, as observed in virtually all tetrapyrrolic complexes of this triad. Nickel 19-25 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 36-40 21619836-13 2011 CONCLUSION: The results of present study showed that methylprednisolone, DDC and methylprednisolone with DDC could improve obviously the repair of rat liver cell damage induced by acute carbonyl nickel poisoning, and the curative effects of early treatment were better than those of later treatment. Nickel 195-201 dopa decarboxylase Rattus norvegicus 73-76 21054559-4 2011 Our findings show that the expression levels of the analysed genes did not differ between allergic patients and healthy controls, while higher expression levels of ETS2 and CASP8 were detected in the nickel-exposed workers. Nickel 200-206 ETS proto-oncogene 2, transcription factor Homo sapiens 164-168 21054559-4 2011 Our findings show that the expression levels of the analysed genes did not differ between allergic patients and healthy controls, while higher expression levels of ETS2 and CASP8 were detected in the nickel-exposed workers. Nickel 200-206 caspase 8 Homo sapiens 173-178 21054559-5 2011 Changes in ETS2 and CASP8 expression are likely to be related to nickel exposure rather than to allergy. Nickel 65-71 ETS proto-oncogene 2, transcription factor Homo sapiens 11-15 21054559-5 2011 Changes in ETS2 and CASP8 expression are likely to be related to nickel exposure rather than to allergy. Nickel 65-71 caspase 8 Homo sapiens 20-25 21068717-9 2011 Low concentrations of nickel, an agent that blocks Ca(v)3.2, had a similar effect. Nickel 22-28 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 51-59 21254280-0 2011 Binding of nickel to testicular glutamate-ammonia ligase inhibits its enzymatic activity. Nickel 11-17 glutamate-ammonia ligase Homo sapiens 32-56 21254280-4 2011 We identified glutamate-ammonia ligase (GLUL) as a prominent nickel-binding protein by mass spectrometry. Nickel 61-67 glutamate-ammonia ligase Homo sapiens 14-38 21254280-4 2011 We identified glutamate-ammonia ligase (GLUL) as a prominent nickel-binding protein by mass spectrometry. Nickel 61-67 glutamate-ammonia ligase Homo sapiens 40-44 21254280-6 2011 We determined that GLUL has a higher affinity for nickel than for its regular co-factor manganese. Nickel 50-56 glutamate-ammonia ligase Homo sapiens 19-23 21254280-8 2011 Upon binding, nickel interferes with the manganese-catalyzed enzymatic activity of recombinant GLUL protein. Nickel 14-20 glutamate-ammonia ligase Homo sapiens 95-99 21254280-10 2011 Our results identify testicular GLUL as the first testicular protein shown to be affected by nickel exposure. Nickel 93-99 glutamate-ammonia ligase Homo sapiens 32-36 21280127-9 2011 A second category of metals, including cobalt, nickel and copper, showed the opposite effects and a unique vitronectin-dependent modulation of PAI-1 stability. Nickel 47-53 vitronectin Homo sapiens 107-118 21280127-9 2011 A second category of metals, including cobalt, nickel and copper, showed the opposite effects and a unique vitronectin-dependent modulation of PAI-1 stability. Nickel 47-53 serpin family E member 1 Homo sapiens 143-148 21280128-7 2011 Steady-state binding measurements using surface plasmon resonance indicated that both active and latent PAI-1 exhibit a dissociation constant in the low micromolar range for binding to immobilized nickel. Nickel 197-203 serpin family E member 1 Homo sapiens 104-109 21280128-9 2011 Changes in the observed rate constants with varying concentrations of metal allowed accurate determination of binding affinities for cobalt, nickel, and copper, yielding dissociation constants of ~40, 30, and 0.09 muM, respectively. Nickel 141-147 latexin Homo sapiens 214-217 21619836-13 2011 CONCLUSION: The results of present study showed that methylprednisolone, DDC and methylprednisolone with DDC could improve obviously the repair of rat liver cell damage induced by acute carbonyl nickel poisoning, and the curative effects of early treatment were better than those of later treatment. Nickel 195-201 dopa decarboxylase Rattus norvegicus 105-108 21266063-2 2011 Chemically regulated promoters, such as the nickel-inducible CYC6 or the low CO2-inducible CAH1 promoter, may prove useful for expressing, at precise times during its cell cycle, proteins with relevant biological functions, or complementing mutants in genes encoding such proteins. Nickel 44-50 uncharacterized protein Chlamydomonas reinhardtii 61-65 21116573-5 2011 A nickel analogue [Ni(1)(2)]Cl(2) 22H(2)O (TIF-5) closely related to TIF-3 is also reported along with two isostructural, non-porous materials [MCl(2)(1)] (M = Mn, TIF-6; M = Cd, TIF-7) based on d(5) and d(10) Mn(II) and Cd(II). Nickel 2-8 TYRO3 protein tyrosine kinase Homo sapiens 43-46 21116573-5 2011 A nickel analogue [Ni(1)(2)]Cl(2) 22H(2)O (TIF-5) closely related to TIF-3 is also reported along with two isostructural, non-porous materials [MCl(2)(1)] (M = Mn, TIF-6; M = Cd, TIF-7) based on d(5) and d(10) Mn(II) and Cd(II). Nickel 2-8 TYRO3 protein tyrosine kinase Homo sapiens 69-72 21116573-5 2011 A nickel analogue [Ni(1)(2)]Cl(2) 22H(2)O (TIF-5) closely related to TIF-3 is also reported along with two isostructural, non-porous materials [MCl(2)(1)] (M = Mn, TIF-6; M = Cd, TIF-7) based on d(5) and d(10) Mn(II) and Cd(II). Nickel 2-8 TYRO3 protein tyrosine kinase Homo sapiens 69-72 21116573-5 2011 A nickel analogue [Ni(1)(2)]Cl(2) 22H(2)O (TIF-5) closely related to TIF-3 is also reported along with two isostructural, non-porous materials [MCl(2)(1)] (M = Mn, TIF-6; M = Cd, TIF-7) based on d(5) and d(10) Mn(II) and Cd(II). Nickel 2-8 TYRO3 protein tyrosine kinase Homo sapiens 69-72 20971118-7 2011 However nickel decreased the rate constant of the caffeine-induced Ca transient in control and detubulated cells, although its effect was greater in control cells, suggesting that Ca extrusion via NCX occurs across the surface and t-tubule membranes. Nickel 8-14 solute carrier family 8 member A1 Rattus norvegicus 197-200 21283523-6 2011 Significant positive correlations were observed between human NIS and ERalpha (r = 0.22, p<0.05) and RARalpha (r = 0.29, p<0.005), with the strongest relationship observed between NIS and RARbeta (r = 0.38, p<0.0001). Nickel 62-65 estrogen receptor 1 Homo sapiens 70-77 21283523-6 2011 Significant positive correlations were observed between human NIS and ERalpha (r = 0.22, p<0.05) and RARalpha (r = 0.29, p<0.005), with the strongest relationship observed between NIS and RARbeta (r = 0.38, p<0.0001). Nickel 62-65 retinoic acid receptor beta Homo sapiens 194-201 20950607-5 2011 The toxic effect of nickel was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase and non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamin C and vitamin E levels were significantly decreased. Nickel 20-26 catalase Rattus norvegicus 137-145 20950607-5 2011 The toxic effect of nickel was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase and non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamin C and vitamin E levels were significantly decreased. Nickel 20-26 hematopoietic prostaglandin D synthase Rattus norvegicus 171-196 20950607-5 2011 The toxic effect of nickel was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase and non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamin C and vitamin E levels were significantly decreased. Nickel 20-26 glutathione-disulfide reductase Rattus norvegicus 198-219 20950607-5 2011 The toxic effect of nickel was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase and non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamin C and vitamin E levels were significantly decreased. Nickel 20-26 glucose-6-phosphate dehydrogenase Rattus norvegicus 224-257 22146730-3 2011 rDPP-IV purified by one-step nickel-affinity chromatography was verified by Western blot and LC-MS/MS analysis. Nickel 29-35 dipeptidylpeptidase 4 Rattus norvegicus 0-7 20300827-2 2011 Recently, we reported significant stimulation of all-trans retinoic acid (atRA)-induced NIS expression in the estrogen-receptor positive human breast cancer cell line MCF-7 by dexamethasone (Dex) in vitro and in vivo, which might offer the potential to image and treat breast cancer with radioiodine. Nickel 88-91 estrogen receptor 1 Homo sapiens 110-127 20300827-3 2011 In this study, based on its known interaction with the pregnane-X-receptor (PXR) forming a heterodimer with the retinoid-X-receptor (RXR), we examined the effect of carbamazepine (CBZ), a potent activator of PXR, on atRA-induced NIS expression and therapeutic efficacy of (131)I in MCF-7 cells. Nickel 229-232 nuclear receptor subfamily 1 group I member 2 Homo sapiens 76-79 21166815-0 2011 Nickel reactivity and filaggrin null mutations--evaluation of the filaggrin bypass theory in a general population. Nickel 0-6 filaggrin Homo sapiens 66-75 21166815-1 2011 BACKGROUND: It was recently shown that filaggrin null mutation carrier status was associated with nickel allergy and self-reported intolerance to costume jewellery. Nickel 98-104 filaggrin Homo sapiens 39-48 21166815-2 2011 Because of the biochemical characteristics of filaggrin, it may show nickel barrier properties in the stratum corneum. Nickel 69-75 filaggrin Homo sapiens 46-55 21166815-3 2011 OBJECTIVES: To investigate whether subjects with filaggrin null mutations report nickel dermatitis at an earlier age than wild-type individuals, and to analyse whether null mutation carriers have stronger patch test reactivity to nickel sulfate than do wild-type individuals. Nickel 81-87 filaggrin Homo sapiens 49-58 21166815-5 2011 RESULTS: The mean number of years at risk of developing nickel dermatitis was significantly lower for the filaggrin null genotype than for the wild-type genotype when ear piercing status was considered. Nickel 56-62 filaggrin Homo sapiens 106-115 21166815-7 2011 CONCLUSIONS: Filaggrin null mutations may lower the age of onset of nickel dermatitis. Nickel 68-74 filaggrin Homo sapiens 13-22 21166815-8 2011 The hypothesis that ear piercings obscure the effect of filaggrin null mutations on the development of nickel allergy in statistical analyses was supported. Nickel 103-109 filaggrin Homo sapiens 56-65 21829649-0 2011 Liprin-alpha4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity. Nickel 30-36 PTPRF interacting protein alpha 4 Homo sapiens 0-13 21402216-1 2011 The nickel- and iron-containing enzyme acetyl-CoA synthase (ACS) catalyzes de novo synthesis as well as overall cleavage of acetyl-CoA in acetogens, various other anaerobic bacteria, methanogens, and other archaea. Nickel 4-10 acyl-CoA synthetase short chain family member 2 Homo sapiens 39-58 21402216-1 2011 The nickel- and iron-containing enzyme acetyl-CoA synthase (ACS) catalyzes de novo synthesis as well as overall cleavage of acetyl-CoA in acetogens, various other anaerobic bacteria, methanogens, and other archaea. Nickel 4-10 acyl-CoA synthetase short chain family member 2 Homo sapiens 60-63 21829649-3 2011 The level of Liprin-alpha4 variants 201 and 004 were highly increased in BEAS-2B cells in response to nickel. Nickel 102-108 PTPRF interacting protein alpha 4 Homo sapiens 13-26 21829649-8 2011 Liprin-alpha4 knock-down lines with decreased expression of Liprin-alpha4 variants 004 and 201 exhibited greater nickel toxicity compared to controls. Nickel 113-119 PTPRF interacting protein alpha 4 Homo sapiens 0-13 21829649-8 2011 Liprin-alpha4 knock-down lines with decreased expression of Liprin-alpha4 variants 004 and 201 exhibited greater nickel toxicity compared to controls. Nickel 113-119 PTPRF interacting protein alpha 4 Homo sapiens 60-73 21829649-10 2011 Liprin-alpha4 appeared necessary for the nickel induced tyrosine phosphatase activity. Nickel 41-47 PTPRF interacting protein alpha 4 Homo sapiens 0-13 21695274-0 2011 A novel stress-associated protein "AtSAP10" from Arabidopsis thaliana confers tolerance to nickel, manganese, zinc, and high temperature stress. Nickel 91-97 stress-associated protein 10 Arabidopsis thaliana 35-42 21131558-9 2010 Strains carrying the crr1-DeltaCys allele upregulate ZRT genes and hyperaccumulate Zn(II), suggesting that the effect of nickel ions may be revealing a role for the C-terminal domain of CRR1 in zinc homeostasis in Chlamydomonas. Nickel 121-127 uncharacterized protein Chlamydomonas reinhardtii 21-25 20213084-0 2010 The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS). Nickel 136-139 arylacetamide deacetylase Homo sapiens 8-11 20213084-4 2010 In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells. Nickel 136-139 arylacetamide deacetylase Homo sapiens 77-80 20213084-4 2010 In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells. Nickel 194-197 arylacetamide deacetylase Homo sapiens 77-80 20881000-0 2010 Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Nickel 12-18 lysine demethylase 3A Homo sapiens 47-53 20881000-0 2010 Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Nickel 12-18 sprouty RTK signaling antagonist 2 Homo sapiens 66-71 20881000-4 2010 Here, we investigated whether inhibition of histone demethylase JMJD1A by hypoxia and nickel could lead to repression/silencing of JMJD1A-targeted gene(s). Nickel 86-92 lysine demethylase 3A Homo sapiens 64-70 20881000-4 2010 Here, we investigated whether inhibition of histone demethylase JMJD1A by hypoxia and nickel could lead to repression/silencing of JMJD1A-targeted gene(s). Nickel 86-92 lysine demethylase 3A Homo sapiens 131-137 20881000-6 2010 Both hypoxia and nickel exposure increased the level of H3K9me2 at the Spry2 promoter by inhibiting JMJD1A, which probably led to a decreased expression of Spry2 in BEAS-2B cells. Nickel 17-23 sprouty RTK signaling antagonist 2 Homo sapiens 71-76 20881000-6 2010 Both hypoxia and nickel exposure increased the level of H3K9me2 at the Spry2 promoter by inhibiting JMJD1A, which probably led to a decreased expression of Spry2 in BEAS-2B cells. Nickel 17-23 lysine demethylase 3A Homo sapiens 100-106 20881000-6 2010 Both hypoxia and nickel exposure increased the level of H3K9me2 at the Spry2 promoter by inhibiting JMJD1A, which probably led to a decreased expression of Spry2 in BEAS-2B cells. Nickel 17-23 sprouty RTK signaling antagonist 2 Homo sapiens 156-161 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 36-42 sprouty RTK signaling antagonist 2 Homo sapiens 14-19 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 36-42 mitogen-activated protein kinase 1 Homo sapiens 51-54 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 134-140 sprouty RTK signaling antagonist 2 Homo sapiens 97-102 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 134-140 mitogen-activated protein kinase 1 Homo sapiens 149-152 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 134-140 sprouty RTK signaling antagonist 2 Homo sapiens 97-102 20881000-7 2010 Repression of Spry2 potentiated the nickel-induced ERK phosphorylation, and forced expression of Spry2 in BEAS-2B cells decreased the nickel-induced ERK phosphorylation and significantly suppressed nickel-induced anchorage-independent growth. Nickel 134-140 mitogen-activated protein kinase 1 Homo sapiens 149-152 20632048-0 2010 Nickel induces oxidative burst, NF-kappaB activation and interleukin-8 production in human neutrophils. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 32-41 20852035-4 2010 The expression of SRC-3 was examined using nickel-intensified IHC. Nickel 43-49 nuclear receptor coactivator 3 Homo sapiens 18-23 20839275-1 2010 The preparation of needle-shaped SnO(2) nanocrystals doped with different concentration of nickel by a simple sol-gel chemical precipitation method is demonstrated. Nickel 91-97 strawberry notch homolog 2 Homo sapiens 33-36 20839275-3 2010 Powder XRD results reveal that the SnO(2) doped with a nickel concentration of up to 1 wt% shows a single crystalline tetragonal rutile phase, whereas a slight change in the crystallite structure is observed for samples with nickel above 1wt%. Nickel 55-61 strawberry notch homolog 2 Homo sapiens 35-38 20839275-3 2010 Powder XRD results reveal that the SnO(2) doped with a nickel concentration of up to 1 wt% shows a single crystalline tetragonal rutile phase, whereas a slight change in the crystallite structure is observed for samples with nickel above 1wt%. Nickel 225-231 strawberry notch homolog 2 Homo sapiens 35-38 20839275-5 2010 The gas sensing properties of the SnO(2) nanocrystals are significantly enhanced after the nickel doping. Nickel 91-97 strawberry notch homolog 2 Homo sapiens 34-37 21033675-0 2010 Localized nanoscopic surface measurements of nickel-modified mica for single-molecule DNA sequence sampling. Nickel 45-51 MHC class I polypeptide-related sequence A Homo sapiens 61-65 21033675-6 2010 Efforts to manipulate and engineer DNA nanostructures would benefit greatly from a better understanding of the surface chemistry of nickel/mica. Nickel 132-138 MHC class I polypeptide-related sequence A Homo sapiens 139-143 21033675-7 2010 Here we present in situ nanometer- and attogram-scale measurements and thermodynamic simulation results that show that the surface chemistry of nickel-treated mica is more complex than generally appreciated by AFM practitioners because of metal-ion speciation effects present at neutral pH. Nickel 144-150 MHC class I polypeptide-related sequence A Homo sapiens 159-163 21033675-8 2010 We also show that, under certain preparations, nickel/mica allows in situ nanoscopic nucleotide sequence mapping within individual surface-adsorbed DNA molecules by permitting localized, controlled desorption of the double helix by soluble DNA binding enzymes. Nickel 47-53 MHC class I polypeptide-related sequence A Homo sapiens 54-58 20632048-0 2010 Nickel induces oxidative burst, NF-kappaB activation and interleukin-8 production in human neutrophils. Nickel 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 57-70 20632048-6 2010 In addition, nickel was shown to activate NF-kappaB and to induce the production of IL-8 in these cells. Nickel 13-19 nuclear factor kappa B subunit 1 Homo sapiens 42-51 20632048-6 2010 In addition, nickel was shown to activate NF-kappaB and to induce the production of IL-8 in these cells. Nickel 13-19 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 20399272-6 2010 EAAT2 was purified from isolated cell membranes in a single step using nickel affinity chromatography. Nickel 71-77 solute carrier family 1 member 2 Homo sapiens 0-5 20860359-9 2010 The efficacy of the nickel procedure has been further applied toward the preparation of heparin disaccharides, GPI anchor pseudodisaccharides, and alpha-GluNAc/GalNAc. Nickel 20-26 glucose-6-phosphate isomerase Homo sapiens 111-114 20820608-0 2010 Synthesis and structures of (dialkylsilylene)bis(phosphine)-nickel, palladium, and platinum complexes and (eta(6)-arene)(dialkylsilylene)nickel complexes. Nickel 137-143 endothelin receptor type A Homo sapiens 107-110 20730162-1 2010 Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes. Nickel 107-113 islet amyloid polypeptide Homo sapiens 250-255 20588260-4 2010 An adenovirus expressing NIS from a telomerase promoter (Ad-hTR-NIS) was cytotoxic combined with relatively high-dose (50 microCi) (131)I therapy and enhanced the efficacy of EBRT combined with low-dose (10 and 25 microCi) (131)I therapy in colorectal and head and neck cancer cells. Nickel 25-28 telomerase RNA component Homo sapiens 60-63 20822182-0 2010 Selective C-4 alkylation of pyridine by nickel/Lewis acid catalysis. Nickel 40-46 complement C4A (Rodgers blood group) Homo sapiens 10-13 20822182-1 2010 Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. Nickel 103-109 complement C4A (Rodgers blood group) Homo sapiens 7-10 20546897-4 2010 We have developed a method for production of highly pure recombinant GAGE12I-His by intracellular expression in yeast (Pichia pastoris) and nickel affinity, ion exchange and gel filtration purification. Nickel 140-146 G antigen 12I Homo sapiens 69-76 20831819-4 2010 METHODS: Baculovirus-expressed, nickel-nitrilotriacetic acid affinity chromatography purified "ZP domain" of human ZP1 was employed to assess its capability to bind and subsequently induce acrosomal exocytosis in capacitated human spermatozoa using tetramethyl rhodamine isothiocyanate conjugated Pisum sativum Agglutinin in absence or presence of various pharmacological inhibitors. Nickel 32-38 zona pellucida glycoprotein 1 Homo sapiens 115-118 20669901-3 2010 The active site of ACS is the A-cluster, which is an unusual nickel-iron-sulfur cluster. Nickel 61-67 acyl-CoA synthetase short chain family member 2 Homo sapiens 19-22 20707311-13 2010 The CoB(8)SH thiolate is 2.6 A closer to the nickel than that of CoBSH, but the additional carbon of CoB(9)SH only decreases the nickel thiolate distance a further 0.3 A. Nickel 45-51 metabolism of cobalamin associated B Homo sapiens 4-7 20856842-2 2010 His-tagged (scFv)-F7N1N2 is the antibody fragment which is directly immobilized, by coordinative bonds, onto ~5 nm nickel islands, then deposited on the surface of a quartz crystal of a quartz crystal microbalance (QCM) to validate the technique. Nickel 115-121 immunglobulin heavy chain variable region Homo sapiens 12-16 20711192-0 2010 Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nickel 85-91 toll like receptor 4 Homo sapiens 23-43 20600219-0 2010 Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2. Nickel 104-110 interleukin 6 Homo sapiens 51-55 21140979-4 2010 CONCLUSION: The influence of golden alloy and cobalt-chromium alloy on RGR is significantly lower than nickel-chromium alloy, meanwhile the damage of DNA caused by golden alloy is lightest, so it is a kind of dental ceramic alloy with good biocompatibility. Nickel 103-109 retinal G protein coupled receptor Mus musculus 71-74 20347490-2 2010 In this report, we expressed the recombinant equine mature interleukin-18 (rEMIL-18) in E. coli and purified it by nickel affinity gel column chromatography. Nickel 115-121 interleukin 18 Equus caballus 59-73 20662514-0 2010 Communication between the zinc and nickel sites in dimeric HypA: metal recognition and pH sensing. Nickel 35-41 pre-mRNA processing factor 40 homolog A Homo sapiens 59-63 20662514-3 2010 HypA contains two metal sites, an intrinsic zinc site and a low-affinity nickel binding site. Nickel 73-79 pre-mRNA processing factor 40 homolog A Homo sapiens 0-4 20662514-4 2010 X-ray absorption spectroscopy (XAS) shows that the structure of the intrinsic zinc site of HypA is dynamic and able to sense both nickel loading and pH changes. Nickel 130-136 pre-mRNA processing factor 40 homolog A Homo sapiens 91-95 20662514-11 2010 Mutation of the histidines that flank the CXXC motifs results in a zinc site structure that is similar to holo-WT-HypA at neutral pH (Zn(Cys)(4)) and is no longer responsive to nickel binding or pH changes. Nickel 177-183 pre-mRNA processing factor 40 homolog A Homo sapiens 114-118 20662514-13 2010 The results are interpreted in terms of a model wherein HypA controls the flow of nickel traffic in the cell in response to nickel availability and pH. Nickel 82-88 pre-mRNA processing factor 40 homolog A Homo sapiens 56-60 20662514-13 2010 The results are interpreted in terms of a model wherein HypA controls the flow of nickel traffic in the cell in response to nickel availability and pH. Nickel 124-130 pre-mRNA processing factor 40 homolog A Homo sapiens 56-60 19846352-1 2010 A carbon-coated nickel magnetic nanoparticles modified glassy carbon electrode (C-Ni/GCE) was fabricated. Nickel 16-22 5'-nucleotidase, cytosolic IA Homo sapiens 80-88 20550150-0 2010 syn-Selective catalytic asymmetric 1,4-addition of alpha-ketoanilides to nitroalkenes under dinuclear nickel catalysis. Nickel 102-108 synemin Homo sapiens 0-3 20597929-0 2010 Nickel (Ni) allergic patients with complications to Ni containing joint replacement show preferential IL-17 type reactivity to Ni. Nickel 0-6 interleukin 17A Homo sapiens 102-107 20392814-5 2010 Thus, NIS inhibitory pathways stimulated by PI3K might also involve the activation of proteins other than MTOR. Nickel 6-9 mechanistic target of rapamycin kinase Rattus norvegicus 106-110 19784841-7 2010 Serum ANA was high in a significant number of rats in both the oral (P < 0.005) and subcutaneously nickel-treated groups (P = 0.02), while the anti-SCL70 was high in a significant number of rats in only the orally nickel-treated group (P = 0.04). Nickel 102-108 Serum cholesterol level QTL 70 Rattus norvegicus 151-156 20507077-1 2010 The distal nickel site of acetyl-CoA synthase (Ni(d)-ACS) and reduced nickel superoxide dismutase (Ni-SOD) display similar square-planar Ni(II)N(2)S(2) coordination environments. Nickel 11-17 acyl-CoA synthetase short chain family member 2 Homo sapiens 53-56 20507077-2 2010 One difference between these two sites, however, is that the nickel ion in Ni-SOD contains a mixed amine/amidate coordination motif while the Ni(d) site in Ni-ACS contains a bisamidate coordination motif. Nickel 61-67 acyl-CoA synthetase short chain family member 2 Homo sapiens 159-162 20346018-0 2010 The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. Nickel 90-96 filaggrin Homo sapiens 46-55 21393765-6 2010 Calculated band structures and valence electron density maps show S-S and Ni-S bonded interactions for NiS(2) under these extremely compressed conditions. Nickel 103-106 solute carrier family 5 member 5 Homo sapiens 74-78 19844976-5 2010 Our results indicate that soluble cobalt, nickel, and molybdenum can induce monocyte up-regulation of T cell costimulatory molecules (CD80, CD86, ICAM-1) in human monocytes/macrophages. Nickel 42-48 CD80 molecule Homo sapiens 134-138 19844976-5 2010 Our results indicate that soluble cobalt, nickel, and molybdenum can induce monocyte up-regulation of T cell costimulatory molecules (CD80, CD86, ICAM-1) in human monocytes/macrophages. Nickel 42-48 CD86 molecule Homo sapiens 140-144 19844976-5 2010 Our results indicate that soluble cobalt, nickel, and molybdenum can induce monocyte up-regulation of T cell costimulatory molecules (CD80, CD86, ICAM-1) in human monocytes/macrophages. Nickel 42-48 intercellular adhesion molecule 1 Homo sapiens 146-152 20024896-6 2010 Cell activity studies showed that ground nickel titanium, spark oxidized and thermally oxidized (at 400 degrees C and below) had higher cellular activity and caused increased alkaline phosphatase (ALP) and osteocalcin (OC) expression which was comparable to control tissue culture plastic and titanium reference samples. Nickel 41-47 alkaline phosphatase, placental Homo sapiens 175-195 20024896-6 2010 Cell activity studies showed that ground nickel titanium, spark oxidized and thermally oxidized (at 400 degrees C and below) had higher cellular activity and caused increased alkaline phosphatase (ALP) and osteocalcin (OC) expression which was comparable to control tissue culture plastic and titanium reference samples. Nickel 41-47 alkaline phosphatase, placental Homo sapiens 197-200 20024896-6 2010 Cell activity studies showed that ground nickel titanium, spark oxidized and thermally oxidized (at 400 degrees C and below) had higher cellular activity and caused increased alkaline phosphatase (ALP) and osteocalcin (OC) expression which was comparable to control tissue culture plastic and titanium reference samples. Nickel 41-47 bone gamma-carboxyglutamate protein Homo sapiens 206-217 20188440-3 2010 named S-NDPK-A and S-NDPK-B were separated and purified from shoots of Alyssum murale (19th day of growth), a nickel accumulator plant, by a four-step procedure involving ammonium sulphate precipitation and DEAE-sepharose and hydroxyapatite column chromatography. Nickel 110-116 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 8-14 20346018-1 2010 BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. Nickel 106-112 filaggrin Homo sapiens 39-48 20346018-1 2010 BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. Nickel 106-112 filaggrin Homo sapiens 55-58 20346018-2 2010 We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Nickel 85-91 filaggrin Homo sapiens 41-50 20346018-3 2010 Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in "bypassing" of the filaggrin proteins. Nickel 79-85 filaggrin Homo sapiens 231-240 20346018-4 2010 OBJECTIVES: To investigate the association between FLG null mutations and (nickel) contact sensitization. Nickel 75-81 filaggrin Homo sapiens 51-54 20346018-8 2010 A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). Nickel 120-126 filaggrin Homo sapiens 97-100 20346018-8 2010 A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). Nickel 120-126 filaggrin Homo sapiens 239-242 20346018-10 2010 CONCLUSIONS: This study suggests that FLG null mutations may be a risk factor for the development of nickel sensitization. Nickel 101-107 filaggrin Homo sapiens 38-41 19538462-2 2010 Here, we demonstrate that certain environmental conditions, such as exposure to the widespread allergen nickel, can dramatically increase the susceptibility of naturally resistant primary endothelial cells or keratinocytes to TRAIL-induced apoptosis. Nickel 104-110 TNF superfamily member 10 Homo sapiens 226-231 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 6-12 TNF superfamily member 10 Homo sapiens 78-83 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 6-12 TNF receptor superfamily member 10a Homo sapiens 94-102 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 6-12 TNF receptor superfamily member 10b Homo sapiens 107-115 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 6-12 TNF receptor superfamily member 10d Homo sapiens 162-170 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 6-12 TNF superfamily member 10 Homo sapiens 94-99 19538462-3 2010 While nickel treatment increased surface expression of the apoptosis-inducing TRAIL receptors TRAIL-R1 and TRAIL-R2, it also up-regulated the apoptosis-deficient TRAIL-R4, suggesting that modulation of TRAIL receptor expression alone is unlikely to fully account for the dramatic sensitization effect of nickel. Nickel 304-310 TNF superfamily member 10 Homo sapiens 78-83 19538462-4 2010 Further analysis of candidate mediators revealed that nickel strongly repressed c-FLIP at mRNA and protein levels. Nickel 54-60 CASP8 and FADD like apoptosis regulator Homo sapiens 80-86 19538462-5 2010 Accordingly, increased activation of Caspase-8 and Caspase-3 following nickel treatment was observed. Nickel 71-77 caspase 8 Homo sapiens 37-46 19538462-5 2010 Accordingly, increased activation of Caspase-8 and Caspase-3 following nickel treatment was observed. Nickel 71-77 caspase 3 Homo sapiens 51-60 19538462-6 2010 Importantly, depletion of c-FLIP by RNA interference could largely recapitulate the effect of nickel and sensitize endothelial cells to TRAIL-dependent apoptosis in the absence of nickel pre-treatment. Nickel 94-100 CASP8 and FADD like apoptosis regulator Homo sapiens 26-32 19538462-7 2010 Conversely, ectopic expression of c-FLIP(L) largely protected nickel-treated cells from TRAIL-mediated apoptosis. Nickel 62-68 CASP8 and FADD like apoptosis regulator Homo sapiens 34-40 19538462-7 2010 Conversely, ectopic expression of c-FLIP(L) largely protected nickel-treated cells from TRAIL-mediated apoptosis. Nickel 62-68 TNF superfamily member 10 Homo sapiens 88-93 20212023-1 2010 The sodium-iodide symporter (NIS) mediates iodide uptake into the thyrocytes, which is important for the diagnosis and therapy of thyroid disorders. Nickel 29-32 solute carrier family 5 member 5 Rattus norvegicus 4-27 20188759-7 2010 After purification by nickel affinity chromatography and refolding, the recombinant protein was used to raise the anti-UL3 polyclonal antibody. Nickel 22-28 nuclear protein UL3 Human alphaherpesvirus 1 119-122 20234340-11 2010 In contrast, survivals of both measles naive and immune mice were extended using MV-NIS-infected MM1 cell carriers. Nickel 84-87 prefoldin 5 Mus musculus 97-100 19863690-2 2010 METHODS AND RESULTS: We isolated strain MA2, showing high copper resistance up to the 1.5 mmol l(-1) concentration; it was also resistant to other metals such as nickel, cobalt and zinc and a group of antibiotics. Nickel 162-168 PNMA family member 2 Homo sapiens 40-43 19538462-0 2010 The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis. Nickel 21-27 TNF superfamily member 10 Homo sapiens 92-97 20359030-1 2010 Si-Si/Si-O dehydrocoupling of hydrosilanes with alcohols (1:1.5 mole ratio), catalyzed by group VIII metallocenes Cp2M" (M" = Co, Ni) which converted to Co(O)/nickel(O) colloidal nanoparticles, produced poly(alkoxysilane)s in one-pot in high yield. Nickel 159-165 cytochrome c oxidase subunit 8A Homo sapiens 96-100 20237193-6 2010 The results presented here demonstrated that nickel-induced apoptosis was independent of the DNA damage response gene, such as hus-1, p53/cep-1 and egl-1. Nickel 45-51 Transcription factor cep-1 Caenorhabditis elegans 138-143 20237193-6 2010 The results presented here demonstrated that nickel-induced apoptosis was independent of the DNA damage response gene, such as hus-1, p53/cep-1 and egl-1. Nickel 45-51 Programmed cell death activator egl-1 Caenorhabditis elegans 148-153 19782138-3 2010 Following auto-induction at 28 degrees C, PPAR alpha LBD protein was purified to electrophoretic homogeneity by a nickel affinity chromatographic step, on-column TEV protease cleavage followed by Sephacryl S200 size exclusion chromatography. Nickel 114-120 peroxisome proliferator activated receptor alpha Homo sapiens 42-52 20113314-6 2010 Our results show that hepcidin-25 can form complexes with copper, nickel and zinc; however, we failed to detect any hepcidin-25 binding to either ferric or ferrous ions. Nickel 66-72 hepcidin antimicrobial peptide Homo sapiens 22-30 20112989-0 2010 Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Nickel 68-74 AKT serine/threonine kinase 1 Homo sapiens 34-37 20112989-0 2010 Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Nickel 68-74 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 38-42 20112989-0 2010 Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Nickel 68-74 mitogen-activated protein kinase 14 Homo sapiens 43-46 20112989-2 2010 The aim of the present study is to elucidate the role of the ROS-mediated Akt/apoptosis-regulating signal kinase (ASK) 1/p38 pathway in nickel-induced apoptosis. Nickel 136-142 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 74-120 20112989-2 2010 The aim of the present study is to elucidate the role of the ROS-mediated Akt/apoptosis-regulating signal kinase (ASK) 1/p38 pathway in nickel-induced apoptosis. Nickel 136-142 mitogen-activated protein kinase 14 Homo sapiens 121-124 20112989-3 2010 Exposure of human bronchial epithelial cells (BEAS-2B) to nickel compounds induced the generation of ROS and activation of Akt that is associated with the activation of ASK1 and p38 mitogen-activated protein kinase. Nickel 58-64 AKT serine/threonine kinase 1 Homo sapiens 123-126 20112989-3 2010 Exposure of human bronchial epithelial cells (BEAS-2B) to nickel compounds induced the generation of ROS and activation of Akt that is associated with the activation of ASK1 and p38 mitogen-activated protein kinase. Nickel 58-64 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 169-173 20112989-3 2010 Exposure of human bronchial epithelial cells (BEAS-2B) to nickel compounds induced the generation of ROS and activation of Akt that is associated with the activation of ASK1 and p38 mitogen-activated protein kinase. Nickel 58-64 mitogen-activated protein kinase 14 Homo sapiens 178-181 20112989-4 2010 Immunoblotting suggested a down-regulation of several antiapoptotic proteins, including Bcl-2 and Bcl-xL in the nickel compound-treated cells. Nickel 112-118 BCL2 apoptosis regulator Homo sapiens 88-93 20112989-4 2010 Immunoblotting suggested a down-regulation of several antiapoptotic proteins, including Bcl-2 and Bcl-xL in the nickel compound-treated cells. Nickel 112-118 BCL2 like 1 Homo sapiens 98-104 20112989-6 2010 N-Acetyl-L-cysteine (NAC, a general antioxidant) and vitamin E or catalase (a specific H(2)O(2) inhibitor) all decreased nickel-induced ROS generation. Nickel 121-127 catalase Homo sapiens 66-74 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 catalase Homo sapiens 43-51 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 AKT serine/threonine kinase 1 Homo sapiens 63-66 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 68-72 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 mitogen-activated protein kinase 14 Homo sapiens 78-81 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 AKT serine/threonine kinase 1 Homo sapiens 153-156 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 157-161 20112989-7 2010 Scavenging of nickel-induced ROS by NAC or catalase attenuated Akt, ASK1, and p38 MAPK activation and apoptosis, which implies involvement of ROS in the Akt/ASK1/p38 pathway. Nickel 14-20 mitogen-activated protein kinase 14 Homo sapiens 162-165 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase 14 Homo sapiens 42-45 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 109-113 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 121-125 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase 14 Homo sapiens 142-145 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 121-125 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 121-125 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase 14 Homo sapiens 142-145 20112989-8 2010 In addition, nickel-induced activation of p38 MAPK was attenuated by a small interference of RNA specific to ASK1 (siRNA ASK1), implying that p38 MAPK was downstream of ASK1, while ASK1 activation was not reversely regulated by the inhibition of p38 MAPK by SB203580, a widely used p38 MAPK inhibitor. Nickel 13-19 mitogen-activated protein kinase 14 Homo sapiens 142-145 20112989-10 2010 Thus, these results suggest that the ROS-dependent Akt-ASK1-p38 axis is important for nickel-induced apoptosis. Nickel 86-92 AKT serine/threonine kinase 1 Homo sapiens 51-54 20112989-10 2010 Thus, these results suggest that the ROS-dependent Akt-ASK1-p38 axis is important for nickel-induced apoptosis. Nickel 86-92 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 55-59 20112989-10 2010 Thus, these results suggest that the ROS-dependent Akt-ASK1-p38 axis is important for nickel-induced apoptosis. Nickel 86-92 mitogen-activated protein kinase 14 Homo sapiens 60-63 20022944-4 2010 EGFR kinase dimerization and activation in vitro was previously reported using a nickel-chelating lipid-liposome system, and we now apply this system to all other members of the EGFR family. Nickel 81-87 epidermal growth factor receptor Homo sapiens 0-4 20022944-4 2010 EGFR kinase dimerization and activation in vitro was previously reported using a nickel-chelating lipid-liposome system, and we now apply this system to all other members of the EGFR family. Nickel 81-87 epidermal growth factor receptor Homo sapiens 178-182 20022944-5 2010 Polyhistidine-tagged Her4, Her2/neu, and Her3 kinase domains are bound to these nickel-liposomes and are brought to high local concentration, mimicking what happens to full-length receptors in vivo following ligand binding. Nickel 80-86 erb-b2 receptor tyrosine kinase 4 Homo sapiens 21-25 20022944-5 2010 Polyhistidine-tagged Her4, Her2/neu, and Her3 kinase domains are bound to these nickel-liposomes and are brought to high local concentration, mimicking what happens to full-length receptors in vivo following ligand binding. Nickel 80-86 erb-b2 receptor tyrosine kinase 2 Homo sapiens 27-35 20022944-5 2010 Polyhistidine-tagged Her4, Her2/neu, and Her3 kinase domains are bound to these nickel-liposomes and are brought to high local concentration, mimicking what happens to full-length receptors in vivo following ligand binding. Nickel 80-86 erb-b2 receptor tyrosine kinase 3 Homo sapiens 41-45 20022944-6 2010 Addition of nickel-liposomes to Her4 kinase domain results in 40-fold activation in kinase activity and marked enhancement of C-terminal tail autophosphorylation. Nickel 12-18 erb-b2 receptor tyrosine kinase 4 Homo sapiens 32-36 20022944-8 2010 Her2/neu kinase activity is also activated by nickel-liposomes, and is increased further by heterodimerization with Her3 or Her4. Nickel 46-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-4 20022944-8 2010 Her2/neu kinase activity is also activated by nickel-liposomes, and is increased further by heterodimerization with Her3 or Her4. Nickel 46-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 5-8 20022944-8 2010 Her2/neu kinase activity is also activated by nickel-liposomes, and is increased further by heterodimerization with Her3 or Her4. Nickel 46-52 erb-b2 receptor tyrosine kinase 3 Homo sapiens 116-120 20022944-8 2010 Her2/neu kinase activity is also activated by nickel-liposomes, and is increased further by heterodimerization with Her3 or Her4. Nickel 46-52 erb-b2 receptor tyrosine kinase 4 Homo sapiens 124-128 20042601-0 2010 Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. Nickel 0-6 lysine demethylase 3A Homo sapiens 40-46 20042601-0 2010 Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. Nickel 0-6 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 69-73 20042601-3 2010 Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as examples, we show that this family of dioxygenases is highly sensitive to inhibition by carcinogenic nickel ions. Nickel 164-170 lysine demethylase 3A Homo sapiens 26-32 20042601-3 2010 Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as examples, we show that this family of dioxygenases is highly sensitive to inhibition by carcinogenic nickel ions. Nickel 164-170 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 55-59 20042601-4 2010 We find that, with iron, the 50% inhibitory concentrations of nickel (IC(50) [Ni(II)]) are 25 microm for JMJD1A and 7.5 microm for ABH2. Nickel 62-68 lysine demethylase 3A Homo sapiens 105-111 20042601-4 2010 We find that, with iron, the 50% inhibitory concentrations of nickel (IC(50) [Ni(II)]) are 25 microm for JMJD1A and 7.5 microm for ABH2. Nickel 62-68 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 131-135 20042601-5 2010 Without iron, JMJD1A is 10 times more sensitive to nickel inhibition with an IC(50) [Ni(II)] of 2.5 microm, and approximately one molecule of Ni(II) inhibits one molecule of JMJD1A, suggesting that nickel causes inhibition by replacing the iron. Nickel 51-57 lysine demethylase 3A Homo sapiens 14-20 20042601-5 2010 Without iron, JMJD1A is 10 times more sensitive to nickel inhibition with an IC(50) [Ni(II)] of 2.5 microm, and approximately one molecule of Ni(II) inhibits one molecule of JMJD1A, suggesting that nickel causes inhibition by replacing the iron. Nickel 198-204 lysine demethylase 3A Homo sapiens 14-20 20042601-6 2010 Furthermore, nickel-bound JMJD1A is not reactivated by excessive iron even up to a 2 mm concentration. Nickel 13-19 lysine demethylase 3A Homo sapiens 26-32 20042601-7 2010 Using x-ray absorption spectroscopy, we demonstrate that nickel binds to the same site in ABH2 as iron, and replacement of the iron by nickel does not prevent the binding of the cofactor 2-oxoglutarate. Nickel 57-63 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 90-94 20042601-8 2010 Finally, we show that nickel ions target and inhibit JMJD1A in intact cells, and disruption of the iron-binding site decreases binding of nickel ions to ABH2 in intact cells. Nickel 22-28 lysine demethylase 3A Homo sapiens 53-59 20042601-8 2010 Finally, we show that nickel ions target and inhibit JMJD1A in intact cells, and disruption of the iron-binding site decreases binding of nickel ions to ABH2 in intact cells. Nickel 138-144 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 153-157 20821442-5 2010 The selected Ni-binding peptides showed similarities to important primary toxicological targets of Ni, such as the hydrogenase nickel incorporation protein (hypB) and the Mg/Ni/Co transporter (corA). Nickel 127-133 SET domain containing 2, histone lysine methyltransferase Homo sapiens 157-161 19819065-2 2010 Transfection of both NIS and HSV1-sr39tk genes to hepatocellular carcinoma cells (Huh-7/NTG) could enhance intracellular accumulation of therapeutic radionuclides and guanosine nucleoside analogue prodrugs to produce better outcomes than single gene therapy. Nickel 21-24 MIR7-3 host gene Homo sapiens 82-87 19831422-3 2010 Metal allergy is mainly an environmental disorder although null mutations in the filaggrin gene complex were recently found to be associated with nickel allergy and dermatitis. Nickel 146-152 filaggrin Homo sapiens 81-90 20025242-5 2010 The sequences for the catalytic domains of Cdc25A, -B, and -C were cloned individually into a prokaryotic expression vector, and their gene products were purified from a bacterial host using nickel affinity chromatography. Nickel 191-197 cell division cycle 25A Homo sapiens 43-49 19727716-15 2010 Transfection of the NIS gene into human anaplastic thyroid cancer induced the accumulation of beta-emitter radionuclides, and cotransfection with a wt-p53 gene enhanced the cytotoxic effect. Nickel 20-23 tumor protein p53 Homo sapiens 151-154 20113795-1 2010 INTRODUCTION: Profile GT files have been redesigned and are now marketed as GTX nickel-titanium rotary files. Nickel 80-86 NK6 homeobox 2 Homo sapiens 76-79 19716420-4 2010 The SSI2 desaturase was purified by nickel ion affinity chromatography and the product obtained showed a single band by SDS-PAGE analysis. Nickel 36-42 Plant stearoyl-acyl-carrier-protein desaturase family protein Arabidopsis thaliana 4-8 20014831-7 2010 The finding that the protein is able to undergo a conformational change upon binding of the second substrate helps to explain the dramatic change in the coordination environment induced in the transition from MCR(red1) to MCR(red2) forms and opens the possibility that nickel coordination geometries other than square planar, tetragonal pyramidal, or elongated octahedral might occur in intermediates of the catalytic cycle. Nickel 269-275 adenosine deaminase RNA specific B1 Homo sapiens 213-217 20014831-7 2010 The finding that the protein is able to undergo a conformational change upon binding of the second substrate helps to explain the dramatic change in the coordination environment induced in the transition from MCR(red1) to MCR(red2) forms and opens the possibility that nickel coordination geometries other than square planar, tetragonal pyramidal, or elongated octahedral might occur in intermediates of the catalytic cycle. Nickel 269-275 adenosine deaminase RNA specific B2 (inactive) Homo sapiens 226-230 20000484-4 2010 RTN1-C(CT) peptide is characterized by the presence of high-affinity copper and nickel ion sites. Nickel 80-86 reticulon 1 Homo sapiens 0-4 20006081-4 2010 Under the optimized conditions, a limit of detection of 10ngL(-1) for nickel is obtained without any analyte-pre-concentration, which is comparable to that using in situ trapping technique. Nickel 70-76 leucine rich repeat containing 4C Homo sapiens 58-64 19781536-3 2010 In this study, we investigated the presence of CaSR in human cultured airway epithelial cells and its activation by nickel. Nickel 116-122 calcium sensing receptor Homo sapiens 47-51 19925783-5 2010 Reversible binding of CYP2C9 via an engineered His tag to a phospholipid bilayer was facilitated using nickel-chelating lipids, presenting potential applications for biosensor technologies. Nickel 103-109 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 22-28 19781536-8 2010 Transfection of specific siRNA inhibited CaSR expression and suppressed nickel-induced intracellular calcium responses in A549 cells thus confirming nickel-CaSR activation. Nickel 72-78 calcium sensing receptor Homo sapiens 156-160 19781536-9 2010 NPS2390, a CaSR antagonist, abolished the calcium response to nickel. Nickel 62-68 calcium sensing receptor Homo sapiens 11-15 19781536-12 2010 In conclusion, micromolar nickel concentrations, relevant to nickel found in the lung tissue of humans exposed to high environmental nickel, trigger intracellular Ca(2+) mobilization in human airway epithelial cells through the activation of CaSR which translates into pathophysiological outputs potentially related to pulmonary disease. Nickel 26-32 calcium sensing receptor Homo sapiens 242-246 20008129-4 2010 T cells from nickel-allergic donors secrete high levels of OPN following antigen-specific stimulation. Nickel 13-19 secreted phosphoprotein 1 Mus musculus 59-62 19962355-4 2010 Accordingly, we have investigated the potential inhibition of polynucleotide kinase (PNK)-dependent single strand break repair by six metals: cadmium, cobalt, copper, nickel, lead and zinc. Nickel 167-173 polynucleotide kinase 3'-phosphatase Homo sapiens 62-83 19962355-4 2010 Accordingly, we have investigated the potential inhibition of polynucleotide kinase (PNK)-dependent single strand break repair by six metals: cadmium, cobalt, copper, nickel, lead and zinc. Nickel 167-173 polynucleotide kinase 3'-phosphatase Homo sapiens 85-88 19733144-1 2010 The standard assay for sodium iodide symporter (NIS) function is based on the measurement of radioiodide uptake ((125)I) in NIS-expressing cells. Nickel 124-127 solute carrier family 5 member 5 Rattus norvegicus 23-46 20696642-3 2010 To investigate the prediction ability of a flow cytometric assay of CD69 up-regulation on CD4+ CLA+ T cells in nickel-sensitive and non-nickel-sensitive patients. Nickel 111-117 CD69 molecule Homo sapiens 68-72 19733144-1 2010 The standard assay for sodium iodide symporter (NIS) function is based on the measurement of radioiodide uptake ((125)I) in NIS-expressing cells. Nickel 48-51 solute carrier family 5 member 5 Rattus norvegicus 23-46 20696642-3 2010 To investigate the prediction ability of a flow cytometric assay of CD69 up-regulation on CD4+ CLA+ T cells in nickel-sensitive and non-nickel-sensitive patients. Nickel 111-117 CD4 molecule Homo sapiens 90-93 20696642-3 2010 To investigate the prediction ability of a flow cytometric assay of CD69 up-regulation on CD4+ CLA+ T cells in nickel-sensitive and non-nickel-sensitive patients. Nickel 111-117 selectin P ligand Homo sapiens 95-98 20484930-0 2010 Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis. Nickel 64-70 heart and neural crest derivatives expressed 2 Mus musculus 0-3 20484930-1 2010 BACKGROUND: The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined. Nickel 88-94 heart and neural crest derivatives expressed 2 Mus musculus 57-60 20378005-0 2010 Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Nickel 26-32 negative elongation factor complex member C/D Homo sapiens 80-83 19883942-7 2010 We found that the two prion proteins exhibited different copper and nickel preferences with the favoured metal binding sites localized at opposite His: His-110 for ChPrP, and His-111 for hPrP. Nickel 68-74 prion protein Homo sapiens 165-169 20696642-0 2010 Association of CD69 up-regulation on CD4+ Cla+ T cells versus patch test, strip patch test and clinical history in nickel sensitization. Nickel 115-121 CD69 molecule Homo sapiens 15-19 20046830-0 2009 Mechanisms of c-myc degradation by nickel compounds and hypoxia. Nickel 35-41 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 20046830-4 2009 We investigated the effect of nickel on c-myc levels, and demonstrated that nickel, hypoxia, and other hypoxia mimetics degraded c-myc protein in a number of cancer cells (A549, MCF-7, MDA-453, and BT-474). Nickel 30-36 MYC proto-oncogene, bHLH transcription factor Homo sapiens 129-134 20046830-4 2009 We investigated the effect of nickel on c-myc levels, and demonstrated that nickel, hypoxia, and other hypoxia mimetics degraded c-myc protein in a number of cancer cells (A549, MCF-7, MDA-453, and BT-474). Nickel 76-82 MYC proto-oncogene, bHLH transcription factor Homo sapiens 40-45 20046830-4 2009 We investigated the effect of nickel on c-myc levels, and demonstrated that nickel, hypoxia, and other hypoxia mimetics degraded c-myc protein in a number of cancer cells (A549, MCF-7, MDA-453, and BT-474). Nickel 76-82 MYC proto-oncogene, bHLH transcription factor Homo sapiens 129-134 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 33-43 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 endothelial PAS domain protein 1 Homo sapiens 48-58 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 MYC proto-oncogene, bHLH transcription factor Homo sapiens 70-75 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 145-155 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 endothelial PAS domain protein 1 Homo sapiens 160-170 20046830-6 2009 Interestingly, knockdown of both HIF-1alpha and HIF-2alpha attenuated c-Myc degradation induced by Nickel and hypoxia, suggesting the functional HIF-1alpha and HIF-2alpha was required for c-myc degradation. Nickel 99-105 MYC proto-oncogene, bHLH transcription factor Homo sapiens 188-193 20046830-7 2009 Further studies revealed two potential pathways mediated nickel and hypoxia induced c-myc degradation. Nickel 57-63 MYC proto-oncogene, bHLH transcription factor Homo sapiens 84-89 20046830-8 2009 Phosphorylation of c-myc at T58 was significantly increased in cells exposed to nickel or hypoxia, leading to increased ubiquitination through Fbw7 ubiquitin ligase. Nickel 80-86 MYC proto-oncogene, bHLH transcription factor Homo sapiens 19-24 20046830-8 2009 Phosphorylation of c-myc at T58 was significantly increased in cells exposed to nickel or hypoxia, leading to increased ubiquitination through Fbw7 ubiquitin ligase. Nickel 80-86 F-box and WD repeat domain containing 7 Homo sapiens 143-147 20046830-9 2009 In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation. Nickel 13-19 ubiquitin specific peptidase 28 Homo sapiens 51-56 20046830-9 2009 In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation. Nickel 13-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 60-65 20046830-9 2009 In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation. Nickel 13-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 139-144 20046830-9 2009 In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation. Nickel 13-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 139-144 20046830-11 2009 Nickel and hypoxia exposure significantly increased the levels of dimethylated H3 lysine 9 at the USP28 promoter and repressed its expression. Nickel 0-6 ubiquitin specific peptidase 28 Homo sapiens 98-103 20046830-12 2009 Our study demonstrated that Nickel and hypoxia exposure increased c-myc T58 phosphorylation and decreased USP28 protein levels in cancer cells, which both lead to enhanced c-myc ubiquitination and proteasomal degradation. Nickel 28-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 66-71 20046830-12 2009 Our study demonstrated that Nickel and hypoxia exposure increased c-myc T58 phosphorylation and decreased USP28 protein levels in cancer cells, which both lead to enhanced c-myc ubiquitination and proteasomal degradation. Nickel 28-34 ubiquitin specific peptidase 28 Homo sapiens 106-111 20046830-12 2009 Our study demonstrated that Nickel and hypoxia exposure increased c-myc T58 phosphorylation and decreased USP28 protein levels in cancer cells, which both lead to enhanced c-myc ubiquitination and proteasomal degradation. Nickel 28-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 172-177 19767646-2 2009 Ferrochelatase shows specificity, in vitro, for multiple metal ion substrates and exhibits substrate inhibition in the case of zinc, copper, cobalt, and nickel. Nickel 153-159 ferrochelatase Homo sapiens 0-14 19769985-0 2009 Crystal structure of HypA, a nickel-binding metallochaperone for [NiFe] hydrogenase maturation. Nickel 29-35 hydrogenase nickel incorporation protein HypA Thermococcus kodakarensis KOD1 21-25 19827795-5 2009 The [Ni(2)(mu-F)(2)(mu-L(m))(2)](BF(4))(2) complex has a dibridging fluoride structure that has a six-coordination environment about each nickel(II) ion. Nickel 138-144 tripartite motif containing 37 Homo sapiens 20-24 19679144-11 2009 IT of nickel and copper increased expression of metallothionein-1 (MT-1) in the lung. Nickel 6-12 metallothionein 1 Rattus norvegicus 48-65 19679144-11 2009 IT of nickel and copper increased expression of metallothionein-1 (MT-1) in the lung. Nickel 6-12 metallothionein 1 Rattus norvegicus 67-71 19679144-12 2009 Zinc, nickel, vanadium, and iron increased hepatic MT-1 expression. Nickel 6-12 metallothionein 1 Rattus norvegicus 51-55 19761259-10 2009 Interaction of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR was then followed by nickel-chelate chromatography. Nickel 123-129 CF transmembrane conductance regulator Homo sapiens 63-67 19861538-1 2009 The activating mutation BRAF(V600E) is a frequent genetic event in papillary thyroid carcinomas (PTC) that predicts a poor prognosis, leading to loss of sodium/iodide symporter (NIS) expression and subsequent radioiodide-refractory metastatic disease. Nickel 178-181 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 24-29 19861538-3 2009 Here, we show a mechanism through which BRAF induces NIS repression and promotes epithelial to mesenchimal transition and invasion based on the operation of an autocrine transforming growth factor (TGF)beta loop. Nickel 53-56 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 40-44 19861538-3 2009 Here, we show a mechanism through which BRAF induces NIS repression and promotes epithelial to mesenchimal transition and invasion based on the operation of an autocrine transforming growth factor (TGF)beta loop. Nickel 53-56 transforming growth factor beta 1 Homo sapiens 198-206 19861538-4 2009 BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. Nickel 121-124 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 0-4 19861538-4 2009 BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. Nickel 121-124 transforming growth factor beta 1 Homo sapiens 37-44 19861538-4 2009 BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. Nickel 121-124 transforming growth factor beta 1 Homo sapiens 58-65 19861538-4 2009 BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. Nickel 121-124 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 108-112 19861538-8 2009 Interestingly, TGFbeta is overexpressed in the invasive front, whereas NIS is preferentially expressed in the central regions of the tumors, suggesting that this negative correlation between TGFbeta and NIS occurs locally inside the tumor. Nickel 71-74 transforming growth factor beta 1 Homo sapiens 191-198 19861538-9 2009 Our study describes a novel mechanism of NIS repression in thyroid cancer and provides evidence that TGFbeta may play a key role in promoting radioiodide resistance and tumor invasion during PTC progression. Nickel 41-44 transforming growth factor beta 1 Homo sapiens 101-108 19449003-1 2009 PURPOSE: ReO(4)(-) has similar kinetics regarding the sodium iodide symporter (NIS) to I(-) and TcO(4)(-) in NIS-expressing tissue. Nickel 79-82 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 54-77 19464111-4 2009 The results showed that nickel, zinc, and chromium have positive effects on beta-C(2)S stabilization (Cr(3+)>Ni(2+)>Zn(2+)), whereas copper has a negative effect. Nickel 24-30 colony stimulating factor 2 receptor subunit beta Homo sapiens 76-82 19464111-7 2009 Moreover, nickel and chromium mainly contributed to stabilizing beta-C(2)S in the belite-rich clinkers produced from the electroplating sludge. Nickel 10-16 colony stimulating factor 2 receptor subunit beta Homo sapiens 64-70 19706688-3 2009 We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (NIS) activity in vitro. Nickel 147-150 PTTG1 interacting protein Rattus norvegicus 26-29 19727688-2 2009 An optimum loading flow rate of 2.25 mL min(-1) for 2 min and an elution flow rate of 2.25 mL min(-1) for 1 min gave an enrichment factor of 15 for nickel. Nickel 148-154 CD59 molecule (CD59 blood group) Homo sapiens 40-46 19727688-2 2009 An optimum loading flow rate of 2.25 mL min(-1) for 2 min and an elution flow rate of 2.25 mL min(-1) for 1 min gave an enrichment factor of 15 for nickel. Nickel 148-154 CD59 molecule (CD59 blood group) Homo sapiens 94-100 19706688-3 2009 We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (NIS) activity in vitro. Nickel 147-150 PTTG1 interacting protein Rattus norvegicus 99-102 19706688-3 2009 We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (NIS) activity in vitro. Nickel 147-150 solute carrier family 5 member 5 Rattus norvegicus 122-145 19706688-4 2009 In subcellular localisation studies, PBF overexpression resulted in the redistribution of NIS from the plasma membrane into intracellular vesicles, where it colocalised with the tetraspanin CD63. Nickel 90-93 PTTG1 interacting protein Rattus norvegicus 37-40 19706688-6 2009 Coimmunoprecipitation and GST-pull-down experiments demonstrated a direct interaction between NIS and PBF, the functional consequence of which was assessed using iodide-uptake studies in rat thyroid FRTL-5 cells. Nickel 94-97 PTTG1 interacting protein Rattus norvegicus 102-105 19706688-8 2009 In summary, we present an entirely novel mechanism by which the proto-oncogene PBF binds NIS and alters its subcellular localisation, thereby regulating its ability to uptake iodide. Nickel 89-92 PTTG1 interacting protein Rattus norvegicus 79-82 19540198-1 2009 Based on nickel-catalyzed cross-labeling where binding partners become biotinylated, we have studied molecular interactions with an N-terminally fused GGH-tag proinsulin C-peptide. Nickel 9-15 gamma-glutamyl hydrolase Homo sapiens 151-154 19540198-1 2009 Based on nickel-catalyzed cross-labeling where binding partners become biotinylated, we have studied molecular interactions with an N-terminally fused GGH-tag proinsulin C-peptide. Nickel 9-15 insulin Homo sapiens 159-169 19720032-4 2009 Because GM2AP extracts lipid ligands from the vesicle and is undergoing exchange on and off the vesicle surface, we utilized a nickel-chelating lipid to localize the paramagnetic metal collider to the lipid bilayer-aqueous interface. Nickel 127-133 ganglioside GM2 activator Homo sapiens 8-13 19539421-3 2009 A significant copper and zinc binding to Abeta1-40 peptide at pH 5.5 was found, whereas nickel ions commonly bind to each molecule of beta-amyloid peptide. Nickel 88-94 amyloid beta precursor protein Homo sapiens 134-154 19470058-2 2009 OBJECTIVE: To evaluate the test sensitivity of SPT in compliance with our recently presented practical method vs. conventional patch test (PT) in nickel- and dichromate-sensitive subjects. Nickel 146-152 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 47-50 19684221-9 2009 Exposure of AQP-expressing oocytes to heavy metals revealed that eel AQP3 is highly sensitive to extracellular nickel and zinc (88.3% and 86.3% inhibition, respectively) but less sensitive to copper (56.4% inhibition). Nickel 111-117 aquaporin 3 (Gill blood group) Homo sapiens 69-73 20136044-2 2009 The potential to accumulate metals like iron, nickel, manganese and copper by Trapa bipinosa was assessed by subjecting them to different effluent concentrations of pulp and paper industry under laboratory conditions. Nickel 46-52 signal sequence receptor subunit 1 Homo sapiens 78-83 19608424-4 2009 The X-ray analysis of [Ni(i-MNT)(2a-5mt)(2)] shows the nickel atom being fourfold coordinated with the two sulfur atoms of the dithiolate (i-MNT) ligand and the endocyclic nitrogen atoms from the two 2a-5mt ring giving rise to a slightly distorted square-planar arrangement. Nickel 55-61 MAX network transcriptional repressor Bos taurus 28-31 19608424-4 2009 The X-ray analysis of [Ni(i-MNT)(2a-5mt)(2)] shows the nickel atom being fourfold coordinated with the two sulfur atoms of the dithiolate (i-MNT) ligand and the endocyclic nitrogen atoms from the two 2a-5mt ring giving rise to a slightly distorted square-planar arrangement. Nickel 55-61 MAX network transcriptional repressor Bos taurus 141-144 19201087-2 2009 In the present study, performance of Dowex HCR S/S cation exchange resin was evaluated for removal of nickel and zinc from aqueous solutions. Nickel 102-108 coiled-coil alpha-helical rod protein 1 Homo sapiens 43-46 19201087-9 2009 Furthermore, separation factors and distribution coefficients of nickel and zinc for Dowex HCR S/S were calculated. Nickel 65-71 coiled-coil alpha-helical rod protein 1 Homo sapiens 91-94 19131640-0 2009 Surfactant-associated protein B is critical to survival in nickel-induced injury in mice. Nickel 59-65 surfactant associated protein B Mus musculus 0-31 19131640-3 2009 We have previously reported that transgenic mice that express transforming growth factor alpha (TGFA) in the lung were protected during nickel-induced lung injury. Nickel 136-142 transforming growth factor alpha Mus musculus 62-94 19131640-3 2009 We have previously reported that transgenic mice that express transforming growth factor alpha (TGFA) in the lung were protected during nickel-induced lung injury. Nickel 136-142 transforming growth factor alpha Mus musculus 96-100 19131640-6 2009 In mouse lung epithelial (MLE-15) cells, microarray analysis demonstrated that nickel increased transcripts of genes enriched in MTF1, E2F-1, and AP-2 transcription factor-binding sites and decreased transcripts of genes enriched in AP-1-binding sites. Nickel 79-85 metal response element binding transcription factor 1 Mus musculus 129-133 19131640-6 2009 In mouse lung epithelial (MLE-15) cells, microarray analysis demonstrated that nickel increased transcripts of genes enriched in MTF1, E2F-1, and AP-2 transcription factor-binding sites and decreased transcripts of genes enriched in AP-1-binding sites. Nickel 79-85 E2F transcription factor 1 Mus musculus 135-140 19131640-7 2009 Nickel also increased Jun transcript and DNA-binding activity, but decreased SFTPB transcript. Nickel 0-6 surfactant associated protein B Mus musculus 77-82 19131640-8 2009 Expression of SFTPB under the control of a doxycycline-sensitive promoter increased survival during nickel-induced injury as compared with control mice. Nickel 100-106 surfactant associated protein B Mus musculus 14-19 18825506-1 2009 In Cupriavidus metallidurans CH34, the proteins CnrX, CnrY, and CnrH regulate the expression of the cnrCBA operon that codes for a cation-efflux pump involved in cobalt and nickel resistance. Nickel 173-179 periplasmic nickel sensor Cupriavidus metallidurans CH34 48-52 19470058-8 2009 RESULTS: According to the estimated test sensitivities, SPT is more sensitive than PT in nickel- and dichromate-sensitive subjects, regardless of the interindividual different numbers of tape strips. Nickel 89-95 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 56-59 18830972-7 2009 A significant increase in HO-1 mRNA levels was detected in nickel treated cells. Nickel 59-65 heme oxygenase 1 Homo sapiens 26-30 18830972-10 2009 We supposed that the immune toxicity of nickel(II) was mainly due to GSH depletion and finally led to apoptosis, probably via changing the expression levels of HO-1 and iNOS in human T lymphocytes. Nickel 40-46 heme oxygenase 1 Homo sapiens 160-164 18830972-10 2009 We supposed that the immune toxicity of nickel(II) was mainly due to GSH depletion and finally led to apoptosis, probably via changing the expression levels of HO-1 and iNOS in human T lymphocytes. Nickel 40-46 nitric oxide synthase 2 Homo sapiens 169-173 19443576-4 2009 This response was accompanied by an increase of the Ca(V)3.2 T-type current, identified with the patch clamp technique by its sensitivity to nickel, and a concomitant acceleration of the myocyte spontaneous contractions. Nickel 141-147 caveolin 3 Rattus norvegicus 52-58 19587996-0 2009 An NMR study on nickel binding sites in Cap43 protein fragments. Nickel 16-22 N-myc downstream regulated 1 Homo sapiens 40-45 19584250-1 2009 A dinuclear nickel complex with methyl and thiolate ligands, Ni(dadt(Et))Ni(Me)(SDmp) (2), has been synthesized as a dinuclear Ni(d)-Ni(p)-site model of acetyl-CoA synthase (ACS) (dadt(Et) is N,N"-diethyl-3,7-diazanonane-1,9-dithiolate; Dmp is 2,6-dimesitylphenyl). Nickel 12-18 acyl-CoA synthetase short chain family member 2 Homo sapiens 174-177 19124200-0 2009 Octadecyl bonded silica membrane disk modified with Cyanex302 for separation and flame atomic absorption spectrometric determination of nickel from tap water and industrial effluent. Nickel 136-142 nuclear RNA export factor 1 Homo sapiens 148-151 19124200-4 2009 The method applied for detection of nickel in tap water and effluent sample had a relative standard deviation (R.S.D.) Nickel 36-42 nuclear RNA export factor 1 Homo sapiens 46-49 19362172-0 2009 Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel. Nickel 62-68 aspartoacylase (aminoacylase) 3 Mus musculus 6-20 19438434-8 2009 Also the cytokine response to nickel varied over time but the patients" mean cytokine response was positively correlated with their mean patch test reactivity (r(s) = 0.70, P < 0.01 for IL-4; r(s) = 0.78, P < 0.001 for IL-13). Nickel 30-36 interleukin 4 Homo sapiens 189-193 19330375-5 2009 The best orientation performance was obtained with Fab-Cys1-biotin on streptavidin-coated plates with increased signal levels of 62%, while oriented immobilization of Fab-His6 and scFv-His6-Cys1 on nickel- and maleimide-coated plates failed to improve the ELISA sensitivity. Nickel 198-204 immunglobulin heavy chain variable region Homo sapiens 180-184 19330375-5 2009 The best orientation performance was obtained with Fab-Cys1-biotin on streptavidin-coated plates with increased signal levels of 62%, while oriented immobilization of Fab-His6 and scFv-His6-Cys1 on nickel- and maleimide-coated plates failed to improve the ELISA sensitivity. Nickel 198-204 cystin 1 Homo sapiens 190-194 19201553-2 2009 A recombinant p24 (rp24) was expressed in the Escherichia coli expression system, purified in a nickel charged resin and used as antigen in the ELISA test. Nickel 96-102 transmembrane p24 trafficking protein 2 Homo sapiens 14-17 21966230-1 2009 Lipid-based nanoparticles (NPs) with a small amount of surface-chelated nickel (Ni-NPs) were developed to easily formulate the HIV his-tagged Tat protein, as well as to formulate and co-deliver two HIV antigens (his-p24 and his-Nef) on one particle. Nickel 72-78 tyrosine aminotransferase Mus musculus 142-145 21966230-1 2009 Lipid-based nanoparticles (NPs) with a small amount of surface-chelated nickel (Ni-NPs) were developed to easily formulate the HIV his-tagged Tat protein, as well as to formulate and co-deliver two HIV antigens (his-p24 and his-Nef) on one particle. Nickel 72-78 TNFAIP3 interacting protein 1 Mus musculus 228-231 19403854-2 2009 The current study investigated the hypothesis that Cr(VI) actively signals through a signal transducer and activator of transcription 1 (STAT1)-dependent pathway to silence nickel (Ni)-induced expression of vascular endothelial cell growth factor A (VEGFA), an important mediator of lung injury and repair. Nickel 173-179 signal transducer and activator of transcription 1 Homo sapiens 85-135 19403854-2 2009 The current study investigated the hypothesis that Cr(VI) actively signals through a signal transducer and activator of transcription 1 (STAT1)-dependent pathway to silence nickel (Ni)-induced expression of vascular endothelial cell growth factor A (VEGFA), an important mediator of lung injury and repair. Nickel 173-179 signal transducer and activator of transcription 1 Homo sapiens 137-142 19403854-2 2009 The current study investigated the hypothesis that Cr(VI) actively signals through a signal transducer and activator of transcription 1 (STAT1)-dependent pathway to silence nickel (Ni)-induced expression of vascular endothelial cell growth factor A (VEGFA), an important mediator of lung injury and repair. Nickel 173-179 vascular endothelial growth factor A Homo sapiens 250-255 18767136-0 2009 Effect of short-time exposures to nickel and lead on brain monoamine oxidase from Danio rerio and Poecilia reticulata. Nickel 34-40 monoamine oxidase Danio rerio 59-76 19505905-0 2009 Effects of nickel on cyclin expression, cell cycle progression and cell proliferation in human pulmonary cells. Nickel 11-17 proliferating cell nuclear antigen Homo sapiens 21-27 19505905-4 2009 Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation. Nickel 53-59 cyclin D1 Homo sapiens 27-36 19505905-4 2009 Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation. Nickel 53-59 proliferating cell nuclear antigen Homo sapiens 27-33 19505905-4 2009 Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation. Nickel 140-146 cyclin D1 Homo sapiens 27-36 19505905-4 2009 Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation. Nickel 140-146 proliferating cell nuclear antigen Homo sapiens 27-33 19505905-5 2009 In addition, we verified that hypoxia-inducible factor-1alpha, an important transcription factor of nickel response, was not required for the cyclin D1 or cyclin E induction. Nickel 100-106 hypoxia inducible factor 1 subunit alpha Homo sapiens 30-61 19505905-7 2009 Further study revealed that cyclin A was not activated in nickel response, and cyclin B1, which not only promotes G(2)/M transition but also prevents M-phase exit of cells if not degraded in time, was up-regulated by nickel through a manner independent of hypoxia-inducible factor. Nickel 217-223 cyclin B1 Homo sapiens 79-88 19505905-8 2009 More importantly, our results verified that overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation. Nickel 123-129 cyclin B1 Homo sapiens 58-67 19505905-8 2009 More importantly, our results verified that overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation. Nickel 123-129 cyclin D1 Homo sapiens 91-100 19505905-8 2009 More importantly, our results verified that overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation. Nickel 123-129 proliferating cell nuclear antigen Homo sapiens 58-64 18767136-1 2009 The aim of this work was to verify, in two small size freshwater teleosts Danio rerio and Poecilia reticulata, the effects of short-time exposures (24 and 72 h) to a sublethal dose (500 microg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme. Nickel 199-205 monoamine oxidase Danio rerio 225-242 18767136-1 2009 The aim of this work was to verify, in two small size freshwater teleosts Danio rerio and Poecilia reticulata, the effects of short-time exposures (24 and 72 h) to a sublethal dose (500 microg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme. Nickel 199-205 monoamine oxidase Danio rerio 244-247 19306907-3 2009 Nickel and/or chromium to mice enhanced the levels of lipid peroxides in the ovary, which was accompanied by a significant decline in the levels of protein, glutathione, total ascorbic acid and activities of superoxide dismutase and catalase. Nickel 0-6 catalase Mus musculus 233-241 19345671-3 2009 We report that Ypk9p localizes to the yeast vacuole and that deletion of YPK9 confers sensitivity for growth for cadmium, manganese, nickel or selenium. Nickel 133-139 putative acid anhydride hydrolase Saccharomyces cerevisiae S288C 15-20 19345671-3 2009 We report that Ypk9p localizes to the yeast vacuole and that deletion of YPK9 confers sensitivity for growth for cadmium, manganese, nickel or selenium. Nickel 133-139 putative acid anhydride hydrolase Saccharomyces cerevisiae S288C 73-77 19038347-5 2009 Upon over-expression of the E. coli chaperones DnaK/DnaJ/GrpE and GroEL/GroES, the yields of 7 from 10 polyhistidine-tagged kinases were increased up to 5-fold after nickel-affinity purification (IMAC). Nickel 166-172 GroEL Escherichia coli 66-71 19675882-3 2009 The importance of NIS to diagnostic and research activities of Nuclear Medicine such as the radioiodine uptake, serum levels of TSH, TPO and TBG and thyroid diseases, especially cancer are described. Nickel 18-21 thyroid peroxidase Homo sapiens 133-136 19675882-3 2009 The importance of NIS to diagnostic and research activities of Nuclear Medicine such as the radioiodine uptake, serum levels of TSH, TPO and TBG and thyroid diseases, especially cancer are described. Nickel 18-21 serpin family A member 7 Homo sapiens 141-144 19288517-4 2009 TAT-HMGB1A-ABP was expressed in E. coli and purified by Nickel chelate chromatography. Nickel 56-62 amine oxidase, copper containing 1 Rattus norvegicus 11-14 19261731-0 2009 Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice. Nickel 22-28 interleukin 1 beta Mus musculus 55-72 19299918-0 2009 Nickel induces secretion of IFN-gamma by splenic natural killer cells. Nickel 0-6 interferon gamma Mus musculus 28-37 19299918-2 2009 Here we show that splenic natural killer cells (NK cells) directly or indirectly respond to nickel by secretion of IFN-gamma. Nickel 92-98 interferon gamma Mus musculus 115-124 19299918-3 2009 Using enzyme-linked immunosorbent spot (ELISPOT) assays, we found that nickel-reactive cells readily secreted IFN-gamma when splenocytes were cultured in the presence of varying concentrations of nickel sulfate (NiSO(4)) for 24 h. However, nickel-reactive IL-2- or IL- 4-secreting cells were infrequent during the 24-h culture with NiSO(4). Nickel 71-77 interferon gamma Mus musculus 110-119 19299918-3 2009 Using enzyme-linked immunosorbent spot (ELISPOT) assays, we found that nickel-reactive cells readily secreted IFN-gamma when splenocytes were cultured in the presence of varying concentrations of nickel sulfate (NiSO(4)) for 24 h. However, nickel-reactive IL-2- or IL- 4-secreting cells were infrequent during the 24-h culture with NiSO(4). Nickel 71-77 interleukin 2 Mus musculus 256-270 19299918-3 2009 Using enzyme-linked immunosorbent spot (ELISPOT) assays, we found that nickel-reactive cells readily secreted IFN-gamma when splenocytes were cultured in the presence of varying concentrations of nickel sulfate (NiSO(4)) for 24 h. However, nickel-reactive IL-2- or IL- 4-secreting cells were infrequent during the 24-h culture with NiSO(4). Nickel 196-202 interferon gamma Mus musculus 110-119 19299918-3 2009 Using enzyme-linked immunosorbent spot (ELISPOT) assays, we found that nickel-reactive cells readily secreted IFN-gamma when splenocytes were cultured in the presence of varying concentrations of nickel sulfate (NiSO(4)) for 24 h. However, nickel-reactive IL-2- or IL- 4-secreting cells were infrequent during the 24-h culture with NiSO(4). Nickel 196-202 interleukin 2 Mus musculus 256-270 19299918-4 2009 Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-g-secreting cells did not increase upon previous exposure to NiSO(4) and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-gamma-secreting cells. Nickel 20-26 interferon gamma Mus musculus 103-108 19299918-4 2009 Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-g-secreting cells did not increase upon previous exposure to NiSO(4) and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-gamma-secreting cells. Nickel 20-26 recombination activating 1 Mus musculus 180-217 19299918-4 2009 Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-g-secreting cells did not increase upon previous exposure to NiSO(4) and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-gamma-secreting cells. Nickel 20-26 interferon gamma Mus musculus 259-268 19299918-4 2009 Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-g-secreting cells did not increase upon previous exposure to NiSO(4) and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-gamma-secreting cells. Nickel 87-93 interferon gamma Mus musculus 103-108 19299918-4 2009 Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-g-secreting cells did not increase upon previous exposure to NiSO(4) and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-gamma-secreting cells. Nickel 87-93 interferon gamma Mus musculus 103-108 19299918-7 2009 These results suggest that there is an early and rapid innate immune response to nickel, which is mediated by NK cells and the NKG2D receptor. Nickel 81-87 killer cell lectin-like receptor subfamily K, member 1 Mus musculus 127-132 19352520-5 2009 Also, reaction of a linear Ni(ii)(3) complex of a tetratopic pyridazine bis-hydrazone ligand with NiN(6) coordination spheres with Cu(ii), leads exclusively to a square Cu(12) grid based complex, and complete displacement of nickel. Nickel 225-231 ninein Homo sapiens 98-101 19379505-0 2009 Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 9-15 caspase 8 Homo sapiens 77-86 19379505-0 2009 Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 9-15 apoptosis inducing factor mitochondria associated 1 Homo sapiens 87-90 19379505-0 2009 Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 9-15 cytochrome c, somatic Homo sapiens 100-112 19379505-12 2009 Interestingly, although an up-regulation of cytochrome c was detected in the mitochondria of metallic nickel particle-treated cells, no cytochrome c release from mitochondria to cytoplasm was found. Nickel 102-108 cytochrome c, somatic Homo sapiens 44-56 19379505-16 2009 Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 41-47 caspase 8 Homo sapiens 84-93 19379505-16 2009 Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 41-47 apoptosis inducing factor mitochondria associated 1 Homo sapiens 94-97 19379505-16 2009 Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase-8/AIF mediated cytochrome c-independent pathway. Nickel 41-47 cytochrome c, somatic Homo sapiens 107-119 19379505-18 2009 Activation of Akt and Bcl-2 may play an important role in preventing cytochrome c release from mitochondria to the cytoplasm and may also be important in the carcinogenicity of metallic nickel particles. Nickel 186-192 AKT serine/threonine kinase 1 Homo sapiens 14-17 19379505-18 2009 Activation of Akt and Bcl-2 may play an important role in preventing cytochrome c release from mitochondria to the cytoplasm and may also be important in the carcinogenicity of metallic nickel particles. Nickel 186-192 BCL2 apoptosis regulator Homo sapiens 22-27 19379505-18 2009 Activation of Akt and Bcl-2 may play an important role in preventing cytochrome c release from mitochondria to the cytoplasm and may also be important in the carcinogenicity of metallic nickel particles. Nickel 186-192 cytochrome c, somatic Homo sapiens 69-81 19351850-8 2009 We previously identified RARbeta and RXRalpha as important for NIS induction by tRA. Nickel 63-66 retinoic acid receptor beta Homo sapiens 25-32 19351850-8 2009 We previously identified RARbeta and RXRalpha as important for NIS induction by tRA. Nickel 63-66 retinoid X receptor alpha Homo sapiens 37-45 19351850-9 2009 Treatment with LY294002, the PI3K inhibitor, or p85alpha knockdown with siRNA abolished tRA-induced NIS expression. Nickel 100-103 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 48-56 19351850-12 2009 Treatment with an Akt inhibitor or Akt knockdown with siRNA reduced NIS expression. Nickel 68-71 AKT serine/threonine kinase 1 Homo sapiens 18-21 19351850-12 2009 Treatment with an Akt inhibitor or Akt knockdown with siRNA reduced NIS expression. Nickel 68-71 AKT serine/threonine kinase 1 Homo sapiens 35-38 19351850-13 2009 These findings indicate that RA induction of NIS in MCF-7 cells is mediated by rapid activation of the PI3K pathway and involves direct interaction with RAR and retinoid X receptor. Nickel 45-48 retinoic acid receptor alpha Homo sapiens 153-156 19351850-13 2009 These findings indicate that RA induction of NIS in MCF-7 cells is mediated by rapid activation of the PI3K pathway and involves direct interaction with RAR and retinoid X receptor. Nickel 45-48 retinoid X receptor alpha Homo sapiens 161-180 19414333-1 2009 Cap43 protein has been proven to be upregulated by nickel compounds or hypoxic stress, often during cell differentiation or cell growth arrest. Nickel 51-57 N-myc downstream regulated 1 Homo sapiens 0-5 18925359-0 2009 Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3"-kinase/Akt signaling. Nickel 0-6 AKT serine/threonine kinase 1 Homo sapiens 111-114 18925359-9 2009 In summary, exposure of HepG2 human hepatoma cells to nickel ions results in stimulation of the Ser/Thr kinase Akt in a PI3K-dependent fashion, activation most likely being independent of oxidative processes. Nickel 54-60 AKT serine/threonine kinase 1 Homo sapiens 111-114 18925359-10 2009 In sharp contrast to copper ions, nickel-induced Akt activation is not propagated further downstream to FoxO-dependent signaling beyond the phosphorylation of FoxO1a and 3a. Nickel 34-40 AKT serine/threonine kinase 1 Homo sapiens 49-52 20147125-5 2009 The NAP1 is then purified by nickel affinity chromatography, followed by anion-exchange chromatography. Nickel 29-35 Nucleosome assembly protein 1 Drosophila melanogaster 4-8 19118932-1 2009 A natural experiment indicated that a link between the presence and concentration of four elements, copper, lead, nickel, and zinc in the influent to two wastewater reclamation plants to the presence and concentrations of the same four elements in the tap water of residential properties. Nickel 114-120 nuclear RNA export factor 1 Homo sapiens 252-255 19038347-5 2009 Upon over-expression of the E. coli chaperones DnaK/DnaJ/GrpE and GroEL/GroES, the yields of 7 from 10 polyhistidine-tagged kinases were increased up to 5-fold after nickel-affinity purification (IMAC). Nickel 166-172 chaperonin GroES Escherichia coli 72-77 19133293-7 2009 RESULTS: Flow cytometry analysis and confocal imaging showed specific staining for mDC exposed to aluminium, chromium, nickel, titanium and zirconium ions. Nickel 119-125 chemokine (C-C motif) ligand 22 Mus musculus 83-86 19292493-1 2009 The reactivity of the nickel(I) dimer [(dippe)Ni(mu-H)](2) (1) with biphenyl-2-thiol was explored with the aim of clarifying the key step of sulfur extrusion during the hydrodesulfurization process using dibenzothiophene (DBT). Nickel 22-28 familial progressive hyperpigmentation 1 Homo sapiens 49-53 19240921-2 2009 These are the first crystallographically established NSHC complexes of nickel in the literature. Nickel 71-77 SHC adaptor protein 3 Homo sapiens 53-57 19152441-9 2009 Moreover, the expression levels of NIS and TSHR were remarkably lower in PTCs harboring the BRAF V600E mutation. Nickel 35-38 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 92-96 19279363-5 2009 Nickel sensitivity, a Th1 immune reaction, seems to be more common in women even if men wear earrings. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 22-25 19235753-9 2009 NIS had a reciprocal relationship with HK I as compared to Glut-1 with respect to staining intensity on each primary tumor (P = .040). Nickel 0-3 hexokinase 1 Homo sapiens 39-43 19235753-10 2009 CONCLUSION: Reciprocal staining pattern of NIS and HK I on primary tumors is related to the staining pattern of NIS and HK I on synchronous as well as occult cervical metastatic tumors. Nickel 43-46 hexokinase 1 Homo sapiens 120-124 19235753-10 2009 CONCLUSION: Reciprocal staining pattern of NIS and HK I on primary tumors is related to the staining pattern of NIS and HK I on synchronous as well as occult cervical metastatic tumors. Nickel 112-115 hexokinase 1 Homo sapiens 51-55 19135467-0 2009 Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Nickel 0-6 MYC proto-oncogene, bHLH transcription factor Homo sapiens 95-100 19135467-0 2009 Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Nickel 0-6 mitogen-activated protein kinase 1 Homo sapiens 109-112 19135467-3 2009 Therefore, the regulation of c-Myc by nickel ions in immortalized but not tumorigenic human bronchial epithelial Beas-2B cells was examined in this study. Nickel 38-44 MYC proto-oncogene, bHLH transcription factor Homo sapiens 29-34 19135467-4 2009 It was found that c-Myc protein expression was increased by nickel ions in non-tumorigenic Beas-2B and human keratinocyte HaCaT cells. Nickel 60-66 MYC proto-oncogene, bHLH transcription factor Homo sapiens 18-23 19135467-6 2009 Knockout of c-Myc and its restoration in a rat cell system confirmed the essential role of c-Myc in nickel ion-induced apoptosis. Nickel 100-106 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 12-17 19135467-6 2009 Knockout of c-Myc and its restoration in a rat cell system confirmed the essential role of c-Myc in nickel ion-induced apoptosis. Nickel 100-106 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 91-96 19135467-7 2009 Further studies in Beas-2B cells showed that nickel ion increased the c-Myc mRNA level and c-Myc promoter activity, but did not increase c-Myc mRNA and protein stability. Nickel 45-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 70-75 19135467-7 2009 Further studies in Beas-2B cells showed that nickel ion increased the c-Myc mRNA level and c-Myc promoter activity, but did not increase c-Myc mRNA and protein stability. Nickel 45-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-96 19135467-7 2009 Further studies in Beas-2B cells showed that nickel ion increased the c-Myc mRNA level and c-Myc promoter activity, but did not increase c-Myc mRNA and protein stability. Nickel 45-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-96 19135467-8 2009 Moreover, nickel ion upregulated c-Myc in Beas-2B cells through the MEK/ERK pathway. Nickel 10-16 MYC proto-oncogene, bHLH transcription factor Homo sapiens 33-38 19135467-8 2009 Moreover, nickel ion upregulated c-Myc in Beas-2B cells through the MEK/ERK pathway. Nickel 10-16 mitogen-activated protein kinase kinase 7 Homo sapiens 68-71 19135467-8 2009 Moreover, nickel ion upregulated c-Myc in Beas-2B cells through the MEK/ERK pathway. Nickel 10-16 mitogen-activated protein kinase 1 Homo sapiens 72-75 19135467-9 2009 Collectively, the results demonstrate that c-Myc induction by nickel ions occurs via an ERK-dependent pathway and plays a crucial role in nickel-induced apoptosis in Beas-2B cells. Nickel 62-68 MYC proto-oncogene, bHLH transcription factor Homo sapiens 43-48 19135467-9 2009 Collectively, the results demonstrate that c-Myc induction by nickel ions occurs via an ERK-dependent pathway and plays a crucial role in nickel-induced apoptosis in Beas-2B cells. Nickel 62-68 mitogen-activated protein kinase 1 Homo sapiens 88-91 19135467-9 2009 Collectively, the results demonstrate that c-Myc induction by nickel ions occurs via an ERK-dependent pathway and plays a crucial role in nickel-induced apoptosis in Beas-2B cells. Nickel 138-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 43-48 19449351-1 2009 Easy breakage to open-shells: The diamagnetic butterfly-like dichalcogen complexes 1 (E = Se) and 2 (E = Te) with a {Ni(II)(2)E(2)} core, undergo facile dissociation in solution via spin crossover to give the unprecedented mononuclear paramagnetic superselenide and supertelluride species 1" and 2", respectively, along with the nickel(I) fragment [LNi(I)]; R = 2,6-diisopropylphenyl. Nickel 329-335 E74 like ETS transcription factor 5 Homo sapiens 86-99 19208242-7 2009 Over expressed 6xHis-UL31 fusion protein was purified by nickel affinity chromatography. Nickel 57-63 UL31 Anatid alphaherpesvirus 1 21-25 19111837-0 2009 Activity of the AtMRP3 promoter in transgenic Arabidopsis thaliana and Nicotiana tabacum plants is increased by cadmium, nickel, arsenic, cobalt and lead but not by zinc and iron. Nickel 121-127 multidrug resistance-associated protein 3 Arabidopsis thaliana 16-22 19200052-0 2009 TNF-alpha induction by nickel compounds is specific through ERKs/AP-1-dependent pathway in human bronchial epithelial cells. Nickel 23-29 tumor necrosis factor Homo sapiens 0-9 19200052-0 2009 TNF-alpha induction by nickel compounds is specific through ERKs/AP-1-dependent pathway in human bronchial epithelial cells. Nickel 23-29 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 65-69 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 tumor necrosis factor Homo sapiens 165-192 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 tumor necrosis factor Homo sapiens 194-203 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 nuclear factor kappa B subunit 1 Homo sapiens 272-293 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 nuclear factor kappa B subunit 1 Homo sapiens 295-304 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 311-330 19200052-3 2009 The current study demonstrates that exposure of human bronchial epithelial cells (Beas-2B) to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1). Nickel 94-100 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 332-336 19200052-4 2009 Further studies show that neither overexpression of IKKbeta-KM, a kinase inactive mutant of IKKbeta, nor the ectopic expression of a dominant negative mutant of NFAT could inhibit the TNF-alpha induction by nickel exposure. Nickel 207-213 tumor necrosis factor Homo sapiens 184-193 19200052-5 2009 Overexpression of TAM67, a dominant-negative mutant of c-Jun, dramatically reduced the TNF-alpha induction, suggesting that AP-1 is a mediator of TNF-alpha induction in nickel responses. Nickel 169-175 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 55-60 19200052-5 2009 Overexpression of TAM67, a dominant-negative mutant of c-Jun, dramatically reduced the TNF-alpha induction, suggesting that AP-1 is a mediator of TNF-alpha induction in nickel responses. Nickel 169-175 tumor necrosis factor Homo sapiens 87-96 19200052-5 2009 Overexpression of TAM67, a dominant-negative mutant of c-Jun, dramatically reduced the TNF-alpha induction, suggesting that AP-1 is a mediator of TNF-alpha induction in nickel responses. Nickel 169-175 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 124-128 19200052-5 2009 Overexpression of TAM67, a dominant-negative mutant of c-Jun, dramatically reduced the TNF-alpha induction, suggesting that AP-1 is a mediator of TNF-alpha induction in nickel responses. Nickel 169-175 tumor necrosis factor Homo sapiens 146-155 19200052-6 2009 Our results show that ERKs are AP-1 upstream kinases responsible for TNF-alpha induction by nickel exposure; although JNKs, ERKs, and p38K were all activated in the Beas-2B cells exposed to nickel compounds. Nickel 92-98 tumor necrosis factor Homo sapiens 69-78 19200052-6 2009 Our results show that ERKs are AP-1 upstream kinases responsible for TNF-alpha induction by nickel exposure; although JNKs, ERKs, and p38K were all activated in the Beas-2B cells exposed to nickel compounds. Nickel 190-196 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 31-35 19200052-6 2009 Our results show that ERKs are AP-1 upstream kinases responsible for TNF-alpha induction by nickel exposure; although JNKs, ERKs, and p38K were all activated in the Beas-2B cells exposed to nickel compounds. Nickel 190-196 tumor necrosis factor Homo sapiens 69-78 19200052-7 2009 Our results demonstrate that inflammatory TNF-alpha could be induced by nickel exposure in Beas-2B cells specifically through an ERKs/AP-1-dependent pathway. Nickel 72-78 tumor necrosis factor Homo sapiens 42-51 19200052-7 2009 Our results demonstrate that inflammatory TNF-alpha could be induced by nickel exposure in Beas-2B cells specifically through an ERKs/AP-1-dependent pathway. Nickel 72-78 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-138 18986691-7 2009 RESULTS: Keratinocytes were found to produce IL-23, but no detectable IL-12, in a response to nickel stimulation. Nickel 94-100 interleukin 23 subunit alpha Homo sapiens 45-50 18986691-9 2009 Inflamed skin of nickel-challenged allergic individuals contained infiltrating neutrophils and cells expressing IL-17, IL-22, CCR6, and IL-22R. Nickel 17-23 interleukin 17A Homo sapiens 112-117 18986691-9 2009 Inflamed skin of nickel-challenged allergic individuals contained infiltrating neutrophils and cells expressing IL-17, IL-22, CCR6, and IL-22R. Nickel 17-23 interleukin 22 Homo sapiens 119-124 18986691-9 2009 Inflamed skin of nickel-challenged allergic individuals contained infiltrating neutrophils and cells expressing IL-17, IL-22, CCR6, and IL-22R. Nickel 17-23 C-C motif chemokine receptor 6 Homo sapiens 126-130 18986691-9 2009 Inflamed skin of nickel-challenged allergic individuals contained infiltrating neutrophils and cells expressing IL-17, IL-22, CCR6, and IL-22R. Nickel 17-23 interleukin 22 receptor subunit alpha 1 Homo sapiens 136-142 19073887-4 2009 Arsenic, mercury, and nickel cause reduction of transcription of ribosome biogenesis genes, which are under the control of Sfp1, a TORC1-regulated transcriptional activator. Nickel 22-28 zinc-coordinating transcription factor SFP1 Saccharomyces cerevisiae S288C 123-127 19154259-5 2009 The frequency of NIS expression in those carcinomas lacking Glut1 expression was significantly higher than in those with Glut1 expression (P = 0.012). Nickel 17-20 solute carrier family 2 member 1 Homo sapiens 60-65 19154259-7 2009 By studying the expression pattern of NIS in lung cancer, the present paper provides a helpful foundation for examining the potential utility of NIS-mediated radioiodide as an alternative diagnostic modality, especially for the management of patients with lung adenocarcinoma lacking Glut1 expression. Nickel 38-41 solute carrier family 2 member 1 Homo sapiens 284-289 19154259-7 2009 By studying the expression pattern of NIS in lung cancer, the present paper provides a helpful foundation for examining the potential utility of NIS-mediated radioiodide as an alternative diagnostic modality, especially for the management of patients with lung adenocarcinoma lacking Glut1 expression. Nickel 145-148 solute carrier family 2 member 1 Homo sapiens 284-289 19036632-5 2009 As results of this research we have obtained and characterized a novel complex, glycinate-guanidoacetate nickel (II), [Ni(Gly)(Gaa)], and we deduced the most probable structure using the experimental data of the infrared spectrum in conjunction with the theoretical DFT procedures. Nickel 105-111 alpha glucosidase Homo sapiens 127-130 19795431-0 2009 Nickel and palladium silyl pincer complexes: unusual structural rearrangements that involve reversible Si-C(sp(3)) and Si-C(sp(2)) bond activation. Nickel 0-6 regulator of calcineurin 2 Homo sapiens 122-129 19572476-0 2009 Contact allergy to nickel: patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes. Nickel 19-25 interleukin 5 Homo sapiens 60-64 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 60-66 interferon gamma Homo sapiens 76-85 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 208-214 interferon gamma Homo sapiens 76-85 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 208-214 interleukin 5 Homo sapiens 133-137 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 208-214 transcobalamin 2 Homo sapiens 157-160 19572476-8 2009 We demonstrate that nickel-specific IL-5 secretion by PBMC is correlated with the intensity of patch test reaction (p=0.05), with no significant effect of IFN-gamma. Nickel 20-26 interleukin 5 Homo sapiens 36-40 19572476-9 2009 An increase in the nickel-specific IL-5 secretion from PBMC by 10 pg/ml is associated with a 10-20% increase (depending on statistical model) in the odds ratio of the patient to have a higher patch test score. Nickel 19-25 interleukin 5 Homo sapiens 35-39 19125725-0 2009 Increased serum levels of IL-22 in patients with nickel contact dermatitis. Nickel 49-55 interleukin 22 Homo sapiens 26-31 18792914-0 2009 Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation. Nickel 22-28 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 101-109 18792914-0 2009 Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation. Nickel 22-28 cyclin D1 Homo sapiens 120-129 18792914-4 2009 The down-regulation of cyclin D1 is due to protein degradation rather than inhibition of transcription, because the nickel compounds treatment did not change cyclin D1 mRNA level, while MG132, the proteasome inhibitor, can rescue the degradation of cyclin D1 caused by soluble nickel compound. Nickel 116-122 cyclin D1 Homo sapiens 23-32 18792914-4 2009 The down-regulation of cyclin D1 is due to protein degradation rather than inhibition of transcription, because the nickel compounds treatment did not change cyclin D1 mRNA level, while MG132, the proteasome inhibitor, can rescue the degradation of cyclin D1 caused by soluble nickel compound. Nickel 277-283 cyclin D1 Homo sapiens 23-32 18792914-5 2009 Moreover, the soluble nickel-induced cyclin D1 degradation is dependent on its Thr286 residue and requires IKKalpha, but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation. Nickel 22-28 cyclin D1 Homo sapiens 37-46 18792914-5 2009 Moreover, the soluble nickel-induced cyclin D1 degradation is dependent on its Thr286 residue and requires IKKalpha, but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation. Nickel 22-28 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 107-115 18792914-5 2009 Moreover, the soluble nickel-induced cyclin D1 degradation is dependent on its Thr286 residue and requires IKKalpha, but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation. Nickel 22-28 cyclin D1 Homo sapiens 179-188 18792914-7 2009 Given the role of cyclin D1 and cell proliferation in carcinogenesis, we anticipate that the different effects of soluble and insoluble nickel compounds on cyclin D1 degradation and cell growth arrest may at least partially account for their different carcinogenic activities. Nickel 136-142 cyclin D1 Homo sapiens 156-165 19136878-9 2009 White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it. Nickel 132-138 interleukin 6 Homo sapiens 22-26 19113573-0 2008 Spin-orbit coupling in ferromagnetic nickel. Nickel 37-43 spindlin 1 Homo sapiens 0-4 19321962-9 2009 RESULTS: NIS-62949 is a potent, highly selective PDE4 inhibitor. Nickel 9-12 phosphodiesterase 4A Homo sapiens 49-53 19321962-13 2009 CONCLUSIONS: Our results report the development of a promising, novel PDE4 inhibitor, NIS-62949, with a wider therapeutic window as compared to second-generation PDE4 inhibitors such as roflumilast. Nickel 86-89 phosphodiesterase 4A Homo sapiens 70-74 19321962-13 2009 CONCLUSIONS: Our results report the development of a promising, novel PDE4 inhibitor, NIS-62949, with a wider therapeutic window as compared to second-generation PDE4 inhibitors such as roflumilast. Nickel 86-89 phosphodiesterase 4A Homo sapiens 162-166 18832182-0 2009 Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 108-118 18832182-0 2009 Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. Nickel 0-6 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 18950672-4 2008 Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. Nickel 191-197 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 48-74 19036708-3 2008 The complex consisting of p110alpha and p85alpha was purified by nickel affinity chromatography. Nickel 65-71 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 26-35 19036708-3 2008 The complex consisting of p110alpha and p85alpha was purified by nickel affinity chromatography. Nickel 65-71 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 40-48 18997042-13 2008 CONCLUSION: Thus, PKC and ERK signaling play important roles in the regulation of NIS function, and control of these signaling pathways may help enhance the efficacy of radioiodide cancer therapy. Nickel 82-85 mitogen-activated protein kinase 3 Homo sapiens 26-29 19048125-6 2008 We used nickel agarose chromatin enrichment, chromatin immunoprecipitation, and the human embryonic kidney-derived cell line HEK293 to identify regulatory elements responding to PAX2. Nickel 8-14 paired box 2 Homo sapiens 178-182 19020710-2 2008 Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. Nickel 31-37 N-myc downstream regulated 1 Homo sapiens 140-145 18992656-1 2008 OBJECTIVES: We examined the sodium-iodide symporter (NIS), which promotes in vivo cellular uptake of technetium 99m ((99m)Tc) or iodine 124 ((124)I), as a reporter gene for cell tracking by single-photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. Nickel 53-56 solute carrier family 5 member 5 Rattus norvegicus 28-51 18981564-0 2008 Toxicity of nickel compounds mediated by HTZ1, histone variant H2A.Z, in Saccharomyces cerevisiae. Nickel 12-18 histone H2AZ Saccharomyces cerevisiae S288C 41-45 18981564-6 2008 Here we demonstrate that a null mutation of H2A.Z (HTZ1 in Saccharomyces cerevisiae), a variant of H2A, decreases the sensitivity to soluble nickel compounds. Nickel 141-147 histone H2AZ Saccharomyces cerevisiae S288C 51-55 18981564-8 2008 Furthermore, sensitivity to nickel compounds of the null mutant of SWR1 encoding the catalytic subunit of the ATP-dependent chromatin remodeling complex that specifically loads Htz1p into chromatin, was identical to that of the htz1 mutant. Nickel 28-34 chromatin-remodeling protein SWR1 Saccharomyces cerevisiae S288C 67-71 18981564-9 2008 Taken together, these results reveal that the incorporation into chromatin, but not acetylation, of Htz1p is important to the toxicity of nickel compounds. Nickel 138-144 histone H2AZ Saccharomyces cerevisiae S288C 100-105 18664540-8 2008 Overexpression of Notch-1 in thyroid cancer cells restores differentiation, reduces cell growth rates, and stimulates NIS expression via a direct action on the NIS promoter. Nickel 118-121 notch receptor 1 Homo sapiens 18-25 19134432-0 2008 Nickel sensitization, hand eczema, and loss-of-function mutations in the filaggrin gene. Nickel 0-6 filaggrin Homo sapiens 73-82 19134432-3 2008 This unique finding may have great implications for our understanding of nickel sensitization because nickel is chelated in the epidermis and perhaps to FLG. Nickel 73-79 filaggrin Homo sapiens 153-156 19134432-3 2008 This unique finding may have great implications for our understanding of nickel sensitization because nickel is chelated in the epidermis and perhaps to FLG. Nickel 102-108 filaggrin Homo sapiens 153-156 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 94-100 filaggrin Homo sapiens 63-66 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 232-238 filaggrin Homo sapiens 63-66 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 232-238 filaggrin Homo sapiens 319-322 18762555-6 2008 Expression of the transcription factor, Pax8, which stimulates NIS expression, was significantly increased in PCCL3 cells after LY294002 treatment. Nickel 63-66 paired box 8 Rattus norvegicus 40-44 18762555-10 2008 Pharmacological inhibition of Akt, a factor stimulated by the PI3K pathway, increased exogenous NIS expression in BHP 2-7 as was seen with LY294002, but not increase the endogenous NIS expression in FRTL-5 cells. Nickel 96-99 AKT serine/threonine kinase 1 Rattus norvegicus 30-33 21832627-3 2008 Depending on the eta value, the thickness distribution of the barrier layer can be made very uniform or highly scattered, which allows us to subsequently fine tune the electrodeposition yield of nickel nanoparticles/nanowires at low voltage. Nickel 195-201 endothelin receptor type A Homo sapiens 17-20 18780212-7 2008 Typically due to the nickel content, Sava sediment quality belongs to class 3 in the period 2001--2004. Nickel 21-27 T-box transcription factor T Homo sapiens 37-41 18780212-9 2008 Moreover, in 2005, sediments from three profiles were extremely polluted with nickel, leading the Sava sediment to class 4, when highest urgency measures are needed. Nickel 78-84 T-box transcription factor T Homo sapiens 98-102 18313216-0 2008 Biosorption of nickel, chromium and zinc by MerP-expressing recombinant Escherichia coli. Nickel 15-21 mercuric transport protein periplasmic component MerP Escherichia coli 44-48 18729364-0 2008 Eta2-organoazide complexes of nickel and their conversion to terminal imido complexes via dinitrogen extrusion. Nickel 30-36 DNA polymerase iota Homo sapiens 0-4 18787710-2 2008 The Chlamydomonas metal-responsive CYC6 promoter is repressed by copper and induced by nickel ions. Nickel 87-93 uncharacterized protein Chlamydomonas reinhardtii 35-39 18759453-2 2008 Nickel transport to the cytoplasm depends on five proteins, NikA-E. We have previously reported the three-dimensional structure of the soluble periplasmic nickel transporter NikA in a complex with FeEDTA(H 2O) (-). Nickel 0-6 relaxosome component Escherichia coli 60-64 18759453-2 2008 Nickel transport to the cytoplasm depends on five proteins, NikA-E. We have previously reported the three-dimensional structure of the soluble periplasmic nickel transporter NikA in a complex with FeEDTA(H 2O) (-). Nickel 0-6 relaxosome component Escherichia coli 174-178 18759453-2 2008 Nickel transport to the cytoplasm depends on five proteins, NikA-E. We have previously reported the three-dimensional structure of the soluble periplasmic nickel transporter NikA in a complex with FeEDTA(H 2O) (-). Nickel 155-161 relaxosome component Escherichia coli 60-64 18759453-2 2008 Nickel transport to the cytoplasm depends on five proteins, NikA-E. We have previously reported the three-dimensional structure of the soluble periplasmic nickel transporter NikA in a complex with FeEDTA(H 2O) (-). Nickel 155-161 relaxosome component Escherichia coli 174-178 18759453-6 2008 Our attempts to obtain a BTC-Ni-NikA complex using apo protein and commercial reagents resulted in nickel-free BTC-NikA. Nickel 99-105 relaxosome component Escherichia coli 32-36 18759453-6 2008 Our attempts to obtain a BTC-Ni-NikA complex using apo protein and commercial reagents resulted in nickel-free BTC-NikA. Nickel 99-105 relaxosome component Escherichia coli 115-119 18050301-5 2008 Nickel and vanadium induced the most DNA damage and were the most apoptotic metals tested, inducing >50% caspase-9 positive T cells at 0.05 mM and 0.1 mM concentrations, respectively. Nickel 0-6 caspase 9 Homo sapiens 108-117 18759560-2 2008 The sodium iodide symporter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC. Nickel 29-32 regenerating family member 3 alpha Homo sapiens 177-180 18611412-5 2008 The expressed VP7 was purified to near homogeneity by chromatography on nickel-agarose column as judged by sodium dodesyl sulfate-polyacrylamide gel electrophoresis analysis. Nickel 72-78 VP7 Bluetongue virus 14-17 18593702-4 2008 These analyses reveal that purified recombinant ferrochelatase from both murine and yeast sources inserts not only ferrous iron but also divalent cobalt, zinc, nickel, and copper into protoporphyrin IX to form the corresponding metalloporphyrins but with considerable mechanistic variability. Nickel 160-166 ferrochelatase Mus musculus 48-62 18580528-5 2008 Subsequently, TrxA-hITF was isolated by Nickel-nitrilotriacetic acid affinity chromatography, and ultrafiltration. Nickel 40-46 trefoil factor 3 Homo sapiens 19-23 18467339-0 2008 Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Nickel 66-72 mitogen-activated protein kinase kinase kinase 1 Mus musculus 0-48 18467339-2 2008 The c-jun N-terminal kinases (JNKs) are regulated through a mitogen-activated protein (MAP) 3 kinase-MAP2 kinase cascade and have been implicated in nickel toxicity. Nickel 149-155 microtubule-associated protein 2 Mus musculus 101-105 18467339-3 2008 In this study, we used genetically modified cells and mice to investigate the involvement of two upstream MAP3Ks, MAP3K1 and 2, in nickel-induced JNK activation and acute lung injury. Nickel 131-137 mitogen-activated protein kinase kinase kinase 1 Mus musculus 114-126 18467339-3 2008 In this study, we used genetically modified cells and mice to investigate the involvement of two upstream MAP3Ks, MAP3K1 and 2, in nickel-induced JNK activation and acute lung injury. Nickel 131-137 mitogen-activated protein kinase 8 Mus musculus 146-149 18467339-7 2008 Accordingly, MAP3K1 ablation in mice resulted in severe nickel-induced acute lung injury and reduced survival. Nickel 56-62 mitogen-activated protein kinase kinase kinase 1 Mus musculus 13-19 18467339-8 2008 Based on these findings, we propose a role for MAP3K1 in reducing JNK activation and protecting the mice from nickel-induced acute lung injury. Nickel 110-116 mitogen-activated protein kinase kinase kinase 1 Mus musculus 47-53 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Nickel 20-26 interleukin 6 Homo sapiens 69-82 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Nickel 20-26 C-C motif chemokine ligand 4 Homo sapiens 87-125 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Nickel 20-26 C-C motif chemokine ligand 4 Homo sapiens 127-136 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Nickel 20-26 C-C motif chemokine ligand 4 Homo sapiens 138-143 18594727-0 2008 Polycarbide nickel clusters containing interstitial Ni(eta2-C2)4 and Ni2(micro-eta2-C2)4 acetylide moieties: mimicking the supersaturated Ni-C solutions preceding the catalytic growth of CNTs with the structures of [HNi25(C2)4(CO)32]3- and [Ni22(C2)4(CO)28Cl]3-. Nickel 12-18 DNA polymerase iota Homo sapiens 55-59 18594727-0 2008 Polycarbide nickel clusters containing interstitial Ni(eta2-C2)4 and Ni2(micro-eta2-C2)4 acetylide moieties: mimicking the supersaturated Ni-C solutions preceding the catalytic growth of CNTs with the structures of [HNi25(C2)4(CO)32]3- and [Ni22(C2)4(CO)28Cl]3-. Nickel 12-18 DNA polymerase iota Homo sapiens 79-83 18281151-1 2008 Cap43 is a nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation. Nickel 11-17 N-myc downstream regulated 1 Homo sapiens 0-5 18375956-0 2008 Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Nickel 0-6 mitogen-activated protein kinase 8 Homo sapiens 81-84 18519666-5 2008 Plk3(-/-) mouse embryonic fibroblasts were hypersensitive to the induction of hypoxia-inducible factor-1 alpha (HIF-1 alpha) under hypoxic conditions or by nickel and cobalt ion treatments. Nickel 156-162 polo like kinase 3 Mus musculus 0-4 18519666-6 2008 Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha induced by nickel or cobalt ions. Nickel 167-173 polo like kinase 3 Mus musculus 26-30 18519666-6 2008 Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha induced by nickel or cobalt ions. Nickel 167-173 polo like kinase 3 Mus musculus 46-50 18519666-6 2008 Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha induced by nickel or cobalt ions. Nickel 167-173 polo like kinase 3 Mus musculus 46-50 18519666-6 2008 Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha induced by nickel or cobalt ions. Nickel 167-173 hypoxia inducible factor 1, alpha subunit Mus musculus 144-155 18049447-0 2008 Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. Nickel 87-93 filaggrin Homo sapiens 34-43 18482439-0 2008 Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Nickel 0-6 interferon gamma Homo sapiens 38-47 18482439-0 2008 Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Nickel 0-6 interleukin 10 Homo sapiens 52-57 18482439-5 2008 RESULTS: We found a specific IFN-gamma response by PBMC upon in vitro stimulation with nickel or palladium in well recognized allergic individuals. Nickel 87-93 interferon gamma Homo sapiens 29-38 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 61-67 interferon gamma Homo sapiens 152-161 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 61-67 interleukin 10 Homo sapiens 205-210 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 168-174 interferon gamma Homo sapiens 152-161 18376818-1 2008 The synthesis and characterization of the two homoleptic mononuclear nickel complexes (2,6-Dipp2C6H3NH)2Ni ( 1) and [2-C(H)NDippC6H4NH] 2Ni (2) (Dipp = 2,6-Pr(i)2C6H3) are described. Nickel 69-75 nudix hydrolase 4 Homo sapiens 145-153 18096868-0 2008 Nickel alterations of TLR2-dependent chemokine profiles in lung fibroblasts are mediated by COX-2. Nickel 0-6 toll like receptor 2 Homo sapiens 22-26 18096868-0 2008 Nickel alterations of TLR2-dependent chemokine profiles in lung fibroblasts are mediated by COX-2. Nickel 0-6 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 18096868-3 2008 Using the Toll-like receptor (TLR)-2 agonist MALP-2 as a lipopeptide relevant to microbial colonization, we hypothesized that nickel sensitizes human lung fibroblasts (HLF) for microbial-driven chemokine release through modulation of TLR signaling pathways. Nickel 126-132 HLF transcription factor, PAR bZIP family member Homo sapiens 168-171 18466065-0 2008 Galvano-spa-bath and health risks due to incorporation of chromium, nickel, and platinum released from electrodes. Nickel 68-74 surfactant protein A2 Homo sapiens 8-11 18319322-7 2008 Inhibitors of the IGF-I receptor, Janus kinase, and phosphatidylinositol 3-kinase (PI3K), significantly reduced NIS mRNA expression and iodide uptake in tRA-stimulated MCF-7 cells but not FRTL-5 cells. Nickel 112-115 insulin like growth factor 1 receptor Homo sapiens 18-32 18319322-11 2008 CONCLUSION: The IGF-I receptor/PI3K pathway mediates tRA-stimulated NIS expression in MCF-7 but not FRTL-5 thyroid cells. Nickel 68-71 insulin like growth factor 1 receptor Homo sapiens 16-30 18250966-6 2008 E-selectin, a marker of endothelial cell injury and activation was found to be significantly up-regulated in cells incubated with wires that released the highest amount of nickel ions. Nickel 172-178 selectin E Homo sapiens 0-10 18322622-1 2008 A novel heterometallic 1D coordination polymer [{Ni(en)2}2(micro-NCS)4Cd(NCS)2](n) x nCH3CN (en = ethylenediamine) has been prepared using the self-assembly process in a one-pot reaction of cadmium oxide, nickel and ammonium thiocyanates with an acetonitrile solution of ethylenediamine. Nickel 205-211 cytosolic thiouridylase subunit 2 Homo sapiens 73-78 18088336-6 2008 The Arabidopsis myb72 knockout mutant was more sensitive to excess Zn or iron (Fe) deficiency than wild type, while Arabidopsis transformants overexpressing bHLH100 showed increased tolerance to high Zn and nickel (Ni) compared to wild-type plants, confirming their role in metal homeostasis in Arabidopsis. Nickel 207-213 basic helix-loop-helix protein 100 Arabidopsis thaliana 157-164 18247621-0 2008 A strategy for C-H activation of pyridines: direct C-2 selective alkenylation of pyridines by nickel/Lewis acid catalysis. Nickel 94-100 complement C2 Homo sapiens 51-54 17989705-9 2008 In conclusion, tumor-specific iodide accumulation was induced in HCC cells by AFP promoter-directed NIS expression in vitro and in vivo, which was sufficiently high to allow a therapeutic effect of (131)I. Nickel 100-103 alpha fetoprotein Homo sapiens 78-81 17997327-3 2008 We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography. Nickel 98-104 influenza virus NS1A binding protein Homo sapiens 76-79 17997327-3 2008 We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography. Nickel 98-104 influenza virus NS1A binding protein Homo sapiens 84-87 18569071-8 2008 The low IL-5 response to TT was associated with a higher induction of the down-regulatory cytokine IL-10 by TT as compared to nickel (p < 0.001). Nickel 126-132 interleukin 5 Homo sapiens 8-12 18569071-4 2008 By IL-4 ELISpot, 74% of the allergic and 0% control subjects responded to nickel and 56% of all subjects to TT. Nickel 74-80 interleukin 4 Homo sapiens 3-7 18569071-5 2008 ELISA detected IL-4 after nickel stimulation only in 13% of the allergic subjects. Nickel 26-32 interleukin 4 Homo sapiens 15-19 18569071-7 2008 In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT. Nickel 26-32 interleukin 5 Homo sapiens 41-45 18569071-7 2008 In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT. Nickel 160-166 interleukin 5 Homo sapiens 41-45 18569071-7 2008 In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT. Nickel 160-166 interleukin 5 Homo sapiens 120-124 18569080-0 2008 Early expression of interleukin-2 mRNA by peripheral blood mononuclear cells isolated from nickel-allergic subjects and subsequently exposed to nickel in vitro. Nickel 91-97 interleukin 2 Homo sapiens 20-33 18569080-0 2008 Early expression of interleukin-2 mRNA by peripheral blood mononuclear cells isolated from nickel-allergic subjects and subsequently exposed to nickel in vitro. Nickel 144-150 interleukin 2 Homo sapiens 20-33 18569080-1 2008 The aim pf the present study was to characterize the time course of the synthesis of mRNA encoding interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) isolated from nickel-allergic women and subsequently exposed to nickel sulphate in vitro. Nickel 180-186 interleukin 2 Homo sapiens 99-112 18569080-1 2008 The aim pf the present study was to characterize the time course of the synthesis of mRNA encoding interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) isolated from nickel-allergic women and subsequently exposed to nickel sulphate in vitro. Nickel 180-186 interleukin 2 Homo sapiens 114-118 18569080-3 2008 The increased level of mRNA coding for IL-2 supports the hypothesis that this process is a key part of the response to nickel stimulation of PBMCs of hypersensitive subjects. Nickel 119-125 interleukin 2 Homo sapiens 39-43 17938229-14 2007 Nickel, but not copper, had the same effect on AQP0 water permeability as zinc. Nickel 0-6 major intrinsic protein of lens fiber S homeolog Xenopus laevis 47-51 18608996-1 2008 Nickel-Titanium suture clips have been developed to enhance suturing in cardiovascular surgery (U-CLIP), Medtronic, Minneapolis, MN, USA). Nickel 0-6 CAP-Gly domain containing linker protein 1 Homo sapiens 98-102 18037383-0 2007 Histidine residues in the IS3-IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel. Nickel 56-62 calcium voltage-gated channel subunit alpha1 E Homo sapiens 91-97 18037383-1 2007 We recently reported that a histidine (H191) in the S3-S4 loop of domain I is critical for nickel inhibition of the Cav3.2 T-type Ca2+ channel. Nickel 91-97 calcium voltage-gated channel subunit alpha1 H Homo sapiens 116-122 18037383-2 2007 As in Cav3.2, two histidine residues are commonly found in the IS3-IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel. Nickel 171-177 calcium voltage-gated channel subunit alpha1 H Homo sapiens 6-12 18037383-2 2007 As in Cav3.2, two histidine residues are commonly found in the IS3-IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel. Nickel 171-177 calcium voltage-gated channel subunit alpha1 E Homo sapiens 90-96 18037383-3 2007 We show here by site-directed mutagenesis and electrophysiology that both residues contribute to the nickel sensitivity of Cav2.3, with H183 being more critical than H179. Nickel 101-107 calcium voltage-gated channel subunit alpha1 E Homo sapiens 123-129 18037383-4 2007 These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3. Nickel 127-133 calcium voltage-gated channel subunit alpha1 E Homo sapiens 162-168 18004418-4 2007 Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support. Nickel 140-146 T-box transcription factor 1 Homo sapiens 49-52 18004418-4 2007 Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support. Nickel 140-146 desmocollin 3 Homo sapiens 54-57 17242865-6 2007 SDS-PAGE and gel filtration analyses revealed that cobalt, nickel and zinc ions permit the formation of stable substrate-GroEL-GroES cis-ternary complexes, but prevent the release of METF from GroEL. Nickel 59-65 heat shock protein family D (Hsp60) member 1 Homo sapiens 121-126 17242865-6 2007 SDS-PAGE and gel filtration analyses revealed that cobalt, nickel and zinc ions permit the formation of stable substrate-GroEL-GroES cis-ternary complexes, but prevent the release of METF from GroEL. Nickel 59-65 heat shock protein family E (Hsp10) member 1 Homo sapiens 127-132 17242865-6 2007 SDS-PAGE and gel filtration analyses revealed that cobalt, nickel and zinc ions permit the formation of stable substrate-GroEL-GroES cis-ternary complexes, but prevent the release of METF from GroEL. Nickel 59-65 heat shock protein family D (Hsp60) member 1 Homo sapiens 193-198 21356991-0 2007 Nickel-Intensified ABC-HRP Antibody Staining of Imaginal Discs in Drosophila. Nickel 0-6 fs(2)abc Drosophila melanogaster 19-22 21356991-2 2007 Labeling is visualized using a nickel-intensified avidin/biotinylated enzyme complex-horseradish peroxidase (ABC-HRP) staining procedure. Nickel 31-37 fs(2)abc Drosophila melanogaster 109-112 18087586-6 2007 They found that average concentrations of nickel or vanadium in PM2.5 (PM with aerodynamic diameter < 2.5 microm) positively modified the lag-1 day association between PM10 and all-cause mortality. Nickel 42-48 ceramide synthase 1 Homo sapiens 141-146 18087586-7 2007 OBJECTIVE: We reestimated the relationship between county-specific lag-1 PM10 (PM with aerodynamic diameter < 10 microm) effects on mortality and county-specific nickel or vanadium PM2.5 average concentrations using 1987-2000 effect estimates. Nickel 165-171 ceramide synthase 1 Homo sapiens 67-72 17931884-7 2007 Urea-solubilized SSX2 was purified by nickel affinity, ion exchange and hydrophobic interaction chromatography. Nickel 38-44 SSX family member 2 Homo sapiens 17-21 18004977-6 2007 Only one line had thyroid-targeted, doxycycline-regulated RET/PTC1 and luciferase coexpression, in which doxycycline induction of RET/PTC1 led to Erk phosphorylation and reduced expression of the sodium/iodide symporter (NIS). Nickel 221-224 ret proto-oncogene Mus musculus 130-133 18004977-8 2007 CONCLUSIONS: We found that acute RET/PTC1 expression can activate the MEK/Erk pathway and downregulate NIS expression in the mouse thyroid gland. Nickel 103-106 ret proto-oncogene Mus musculus 33-36 18004977-8 2007 CONCLUSIONS: We found that acute RET/PTC1 expression can activate the MEK/Erk pathway and downregulate NIS expression in the mouse thyroid gland. Nickel 103-106 patched 1 Mus musculus 37-41 17601807-5 2007 Both plasmids were successfully expressed in E. coli, and the recombinant protein PepD-His was purified using nickel-chelating affinity chromatography and reconfirmed by internal amino acid sequencing. Nickel 110-116 C69 family dipeptidase Bifidobacterium longum NCC2705 82-86 17854178-11 2007 The role of Ni-S pi bonding in nickel-cysteine geometries will be discussed, including how these results suggest a mechanism for the movement of electron density from nickel onto the backbone of coordinated cysteine. Nickel 31-37 solute carrier family 5 member 5 Homo sapiens 12-16 17854178-11 2007 The role of Ni-S pi bonding in nickel-cysteine geometries will be discussed, including how these results suggest a mechanism for the movement of electron density from nickel onto the backbone of coordinated cysteine. Nickel 167-173 solute carrier family 5 member 5 Homo sapiens 12-16 17915885-3 2007 Treatment of the resulting 2-deoxy-2-thiotolyl-glycosides with hydrogen and Raney nickel affords the corresponding 2-deoxy-furanosides with a 1,3-syn relationship. Nickel 82-88 synemin Homo sapiens 146-149 17715992-0 2007 Picomolar detection of insulin at renewable nickel powder-doped carbon composite electrode. Nickel 44-50 insulin Homo sapiens 23-30 17715992-3 2007 The nickel powder was then oxidized to form a nickel oxide film electrode, which was used as an amperometric detector for hydrodynamic amperometry and flow injection analysis of insulin. Nickel 4-10 insulin Homo sapiens 178-185 17894822-1 2007 Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt. Nickel 251-257 tumor protein, translationally-controlled 1 Homo sapiens 24-28 17894822-3 2007 PMA, forskolin, dioxin, cobalt and nickel induced TCTP expression in 24 h in both cell lines about 2.2-3.2-fold at the mRNA level and 1.6-2.2-fold at the protein level. Nickel 35-41 tumor protein, translationally-controlled 1 Homo sapiens 50-54 17894822-7 2007 Post-transcriptional activation of TCTP expression was associated with the action of dioxin, nickel, cobalt (1.8-2.3-fold) and copper (2.5-3.0-fold), whereas stimulation of TCTP synthesis by copper was mediated by the TCTP mRNA 3"-UTR (3.2-fold) but not by the 5"-UTR (0.5-fold). Nickel 93-99 tumor protein, translationally-controlled 1 Homo sapiens 35-39 17726079-2 2007 NIS is expressed in trophoblast and is regulated by human choriogonadotropin (hCG). Nickel 0-3 hypertrichosis 2 (generalised, congenital) Homo sapiens 78-81 17726079-16 2007 This may occur through modulation of hCG effects on NIS and hCG gene expression. Nickel 52-55 hypertrichosis 2 (generalised, congenital) Homo sapiens 37-40 17712002-3 2007 METHODS: Methyl-binding domain (MBD) protein was produced using a pET6HMBD plasmid with MBD DNA sequence cloned from rat MeCP2 gene and bound to a column of nickel-agarose resin. Nickel 157-163 methyl CpG binding protein 2 Rattus norvegicus 121-126 17636966-1 2007 Oxidative addition of H2 to Ni(PH3)2 was theoretically studied as a prototype of nickel-catalyzed sigma-bond activation reaction, where CASSCF, CASPT2, CCSD(T), broken symmetry (Bs) MP2 to MP4(SDTQ), and DFT methods were employed. Nickel 81-87 tryptase pseudogene 1 Homo sapiens 182-185 17671363-3 2007 A recombinant mutant of Tsa1 from S. cerevisiae, with Cys47 substituted by serine, was overexpressed in Escherichia coli as a His(6)-tagged fusion protein and purified by nickel-affinity chromatography. Nickel 171-177 thioredoxin peroxidase TSA1 Saccharomyces cerevisiae S288C 24-28 17616122-4 2007 Both reagents serve to transfer PNP into the coordination sphere of divalent nickel, palladium, and platinum. Nickel 77-83 purine nucleoside phosphorylase Homo sapiens 32-35 17616122-5 2007 [(PNP)Ag]2 is able to effect PNP transfer in air, but the transfer to nickel(II) is less efficient than that with the thallium(I) analogue. Nickel 70-76 purine nucleoside phosphorylase Homo sapiens 2-5 17489975-7 2007 RESULTS: In vitro activation of psoriatic as well as antigen (nickel)-specific skin-homing T cells was strongly and dose-dependently impaired by infliximab, in terms both of proliferation and of IFN-gamma release. Nickel 62-68 interferon gamma Homo sapiens 195-204 17297475-4 2007 We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake. Nickel 96-99 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 17-21 18409814-5 2007 Nickel contact at very low concentrations (10(-5), 10(-6) M) induced upregulation of MMP-2 and IL-8 mRNA production; chromium contact at very low concentrations killed all cells. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 85-90 18409814-5 2007 Nickel contact at very low concentrations (10(-5), 10(-6) M) induced upregulation of MMP-2 and IL-8 mRNA production; chromium contact at very low concentrations killed all cells. Nickel 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 95-99 17297475-4 2007 We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake. Nickel 96-99 PTTG1 interacting protein Homo sapiens 45-48 17518770-0 2007 Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings. Nickel 47-53 matrix metallopeptidase 2 Homo sapiens 62-88 17538231-6 2007 Addition of nifedipine did not but addition of nifedipine and nickel (Na+ -Ca2+ exchanger inhibitor) did cause a statistically significant rightward shift of the pinacidil concentration-relaxation curve, although the effect 0.1 mM pinacidil was preserved. Nickel 62-68 solute carrier family 8 member A1 Homo sapiens 70-89 17540900-2 2007 Data from experiments performed on iron-sulfur and iron-nickel-sulfur systems at pressures corresponding to the center of Mars indicate that its core is presently completely liquid and that it will not form an outwardly crystallizing iron-rich inner core, as does Earth. Nickel 56-62 methionyl-tRNA synthetase 1 Homo sapiens 122-126 17475259-2 2007 In response to heavy metals including cadmium, nickel and cobalt, hepatocytes and renal tubular cells expressing ES-TRAP exhibited ER stress and decreased ES-TRAP activity. Nickel 47-53 acid phosphatase 5, tartrate resistant Mus musculus 116-120 17475259-2 2007 In response to heavy metals including cadmium, nickel and cobalt, hepatocytes and renal tubular cells expressing ES-TRAP exhibited ER stress and decreased ES-TRAP activity. Nickel 47-53 acid phosphatase 5, tartrate resistant Mus musculus 158-162 17442357-6 2007 Induction of apoptotic cell death by nickel was mediated by reduction of bcl-2 expression. Nickel 37-43 BCL2 apoptosis regulator Homo sapiens 73-78 17471379-2 2007 The tetranuclear nickel cluster , [Ni(2)[dpk(O)(OH)][dpk(O)(OCH(3))](N(3))(2)](2), is centrosymmetric with a central core described as an edge-shared triangle core. Nickel 17-23 TAO kinase 3 Homo sapiens 41-44 17471379-2 2007 The tetranuclear nickel cluster , [Ni(2)[dpk(O)(OH)][dpk(O)(OCH(3))](N(3))(2)](2), is centrosymmetric with a central core described as an edge-shared triangle core. Nickel 17-23 TAO kinase 3 Homo sapiens 53-56 17518770-2 2007 We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). Nickel 92-98 matrix metallopeptidase 2 Homo sapiens 26-52 17518770-2 2007 We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). Nickel 92-98 matrix metallopeptidase 2 Homo sapiens 54-59 17518770-5 2007 RESULTS: Our results indicate that nickel-induced MMP-2 production was inhibited with PTK, PKC and AP-1 specific inhibitors. Nickel 35-41 matrix metallopeptidase 2 Homo sapiens 50-55 17518770-5 2007 RESULTS: Our results indicate that nickel-induced MMP-2 production was inhibited with PTK, PKC and AP-1 specific inhibitors. Nickel 35-41 protein tyrosine kinase 2 beta Homo sapiens 86-89 17518770-5 2007 RESULTS: Our results indicate that nickel-induced MMP-2 production was inhibited with PTK, PKC and AP-1 specific inhibitors. Nickel 35-41 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 99-103 17518770-7 2007 CONCLUSIONS: Using HaCat, we showed that curcumin and genistein can revert nickel-induced MMP-2 upregulation. Nickel 75-81 matrix metallopeptidase 2 Homo sapiens 90-95 17382205-0 2007 The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Nickel 114-120 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-53 17464061-3 2007 Among the accessory/maturation proteins, the nickel-binding HypA protein has been previously shown to be required for the full activity of both the hydrogenase and the urease enzymes, while another nickel-binding protein, UreE, is known to be solely involved in the urease maturation process. Nickel 45-51 hypA Escherichia coli 60-64 17464061-3 2007 Among the accessory/maturation proteins, the nickel-binding HypA protein has been previously shown to be required for the full activity of both the hydrogenase and the urease enzymes, while another nickel-binding protein, UreE, is known to be solely involved in the urease maturation process. Nickel 198-204 hypA Escherichia coli 60-64 17464061-7 2007 By using a two-plasmid system in Escherichia coli, the highest urease activity was achieved under low nickel conditions only when the UreE protein was expressed along with the wild-type HypA protein, but not with its nickel-binding-deficient variant HypA H2A. Nickel 102-108 hypA Escherichia coli 186-190 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 41-47 hypA Escherichia coli 62-66 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 41-47 hypA Escherichia coli 169-173 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 41-47 hypA Escherichia coli 169-173 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 62-66 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 169-173 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 169-173 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 62-66 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 169-173 17464061-9 2007 Although various attempts to show direct nickel transfer from HypA to UreE failed, these results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori. Nickel 135-141 hypA Escherichia coli 169-173 17331979-8 2007 The frataxin/ISD11 interaction was also decreased by the chelator EDTA, and was increased by supplementation with nickel but not other metal ions. Nickel 114-120 frataxin Homo sapiens 4-12 17331979-8 2007 The frataxin/ISD11 interaction was also decreased by the chelator EDTA, and was increased by supplementation with nickel but not other metal ions. Nickel 114-120 Isd11p Saccharomyces cerevisiae S288C 13-18 17331979-9 2007 Nickel supplementation rescued the defective interaction of mutant frataxin I154F and W155R with ISD11. Nickel 0-6 frataxin Homo sapiens 67-75 17331979-9 2007 Nickel supplementation rescued the defective interaction of mutant frataxin I154F and W155R with ISD11. Nickel 0-6 Isd11p Saccharomyces cerevisiae S288C 97-102 17382205-9 2007 These data correlate with extended stabilization of HIF-1alpha after acute exposure to nickel(II). Nickel 87-93 hypoxia inducible factor 1 subunit alpha Homo sapiens 52-62 17158598-7 2007 Both nickel and SKF-96365 (10 microM) inhibited the increase of the I(K(Ca)) induced by BK; however, the l-type Ca2+ channel blocker, nifedipine, had no effect. Nickel 5-11 kininogen 1 Homo sapiens 88-90 16872867-1 2007 Nickel(II) complexes of isatin-3,2"-quinolyl-hydrazones of the type [Ni(L)X] (where X=Cl-, Br-, NO3-, CH3COO- and ClO4-] and their adducts Ni(L)X.2Y [where Y=pyridine or dioxane and X=Cl-, Br-, NO3- and ClO4-] have been synthesized under controlled experimental conditions and characterized by using the modern spectroscopic and physicochemical techniques viz. Nickel 0-6 NBL1, DAN family BMP antagonist Homo sapiens 96-99 17065197-0 2007 JNK1, but not JNK2, is required for COX-2 induction by nickel compounds. Nickel 55-61 mitogen-activated protein kinase 8 Homo sapiens 0-4 17065197-0 2007 JNK1, but not JNK2, is required for COX-2 induction by nickel compounds. Nickel 55-61 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-41 17065197-2 2007 In the present study, we found nickel exposure could induce cyclooxygenase-2 (COX-2) expression at transcriptional and protein levels in both human bronchoepithelial cells (Beas-2B) and murine embryonic fibroblasts (MEFs). Nickel 31-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 60-76 17065197-2 2007 In the present study, we found nickel exposure could induce cyclooxygenase-2 (COX-2) expression at transcriptional and protein levels in both human bronchoepithelial cells (Beas-2B) and murine embryonic fibroblasts (MEFs). Nickel 31-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 78-83 17065197-4 2007 Our results demonstrated that COX-2 induction by nickel was impaired in JNK1(-/-) MEFs, but not in JNK2(-/-) MEFs. Nickel 49-55 prostaglandin-endoperoxide synthase 2 Homo sapiens 30-35 17065197-4 2007 Our results demonstrated that COX-2 induction by nickel was impaired in JNK1(-/-) MEFs, but not in JNK2(-/-) MEFs. Nickel 49-55 mitogen-activated protein kinase 8 Homo sapiens 72-76 17065197-6 2007 Further investigation revealed that JNK1 mediated the nickel-induced COX-2 expression in a c-Jun/AP-1-dependent manner. Nickel 54-60 mitogen-activated protein kinase 8 Homo sapiens 36-40 17065197-6 2007 Further investigation revealed that JNK1 mediated the nickel-induced COX-2 expression in a c-Jun/AP-1-dependent manner. Nickel 54-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 69-74 17065197-6 2007 Further investigation revealed that JNK1 mediated the nickel-induced COX-2 expression in a c-Jun/AP-1-dependent manner. Nickel 54-60 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 91-96 17065197-6 2007 Further investigation revealed that JNK1 mediated the nickel-induced COX-2 expression in a c-Jun/AP-1-dependent manner. Nickel 54-60 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 97-101 17065197-8 2007 Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression. Nickel 109-115 mitogen-activated protein kinase 8 Homo sapiens 33-37 17065197-8 2007 Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression. Nickel 109-115 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 38-43 17065197-8 2007 Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression. Nickel 109-115 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 44-48 17065197-8 2007 Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression. Nickel 109-115 prostaglandin-endoperoxide synthase 2 Homo sapiens 124-129 16872867-1 2007 Nickel(II) complexes of isatin-3,2"-quinolyl-hydrazones of the type [Ni(L)X] (where X=Cl-, Br-, NO3-, CH3COO- and ClO4-] and their adducts Ni(L)X.2Y [where Y=pyridine or dioxane and X=Cl-, Br-, NO3- and ClO4-] have been synthesized under controlled experimental conditions and characterized by using the modern spectroscopic and physicochemical techniques viz. Nickel 0-6 NBL1, DAN family BMP antagonist Homo sapiens 194-197 17312168-0 2007 The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. Nickel 21-27 nuclear factor kappa B subunit 1 Homo sapiens 119-128 17312168-4 2007 The bulk of those genes were identified as targets of two distinct signaling cascades, the IKK2/NF-kappaB pathway and a proangiogenic pathway mediated by HIF-1alpha, which accumulates upon exposure to nickel. Nickel 201-207 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 91-95 17312168-4 2007 The bulk of those genes were identified as targets of two distinct signaling cascades, the IKK2/NF-kappaB pathway and a proangiogenic pathway mediated by HIF-1alpha, which accumulates upon exposure to nickel. Nickel 201-207 nuclear factor kappa B subunit 1 Homo sapiens 96-105 17312168-4 2007 The bulk of those genes were identified as targets of two distinct signaling cascades, the IKK2/NF-kappaB pathway and a proangiogenic pathway mediated by HIF-1alpha, which accumulates upon exposure to nickel. Nickel 201-207 hypoxia inducible factor 1 subunit alpha Homo sapiens 154-164 17277087-6 2007 zif1 mutants were also more sensitive to cadmium but less sensitive to nickel. Nickel 71-77 zinc induced facilitator 1 Arabidopsis thaliana 0-4 17312168-6 2007 NF-kappaB activation mediates most of the proinflammatory responses to nickel. Nickel 71-77 nuclear factor kappa B subunit 1 Homo sapiens 0-9 17312168-7 2007 Nickel-dependent HIF-1alpha activation primarily modulates expression of genes involved in proliferation, survival, metabolism, and signaling, albeit the induction of some proinflammatory nickel-response genes, most prominently IL-6, which we identified as novel bona fide HIF-1alpha target in this study, is also critically dependent on this pathway. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 17-27 17312168-7 2007 Nickel-dependent HIF-1alpha activation primarily modulates expression of genes involved in proliferation, survival, metabolism, and signaling, albeit the induction of some proinflammatory nickel-response genes, most prominently IL-6, which we identified as novel bona fide HIF-1alpha target in this study, is also critically dependent on this pathway. Nickel 0-6 interleukin 6 Homo sapiens 228-232 17312168-7 2007 Nickel-dependent HIF-1alpha activation primarily modulates expression of genes involved in proliferation, survival, metabolism, and signaling, albeit the induction of some proinflammatory nickel-response genes, most prominently IL-6, which we identified as novel bona fide HIF-1alpha target in this study, is also critically dependent on this pathway. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 273-283 17312168-9 2007 Taken together, our data provide mechanistic insight into the complex network of nickel-induced cellular events and identify IKK2/NF-kappaB and HIF-1alpha as important pathways involved in processes such as delivery of "second signals" in contact hypersensitivity reactions to nickel. Nickel 81-87 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 125-129 17312168-9 2007 Taken together, our data provide mechanistic insight into the complex network of nickel-induced cellular events and identify IKK2/NF-kappaB and HIF-1alpha as important pathways involved in processes such as delivery of "second signals" in contact hypersensitivity reactions to nickel. Nickel 81-87 nuclear factor kappa B subunit 1 Homo sapiens 130-139 17312168-9 2007 Taken together, our data provide mechanistic insight into the complex network of nickel-induced cellular events and identify IKK2/NF-kappaB and HIF-1alpha as important pathways involved in processes such as delivery of "second signals" in contact hypersensitivity reactions to nickel. Nickel 81-87 hypoxia inducible factor 1 subunit alpha Homo sapiens 144-154 17312168-9 2007 Taken together, our data provide mechanistic insight into the complex network of nickel-induced cellular events and identify IKK2/NF-kappaB and HIF-1alpha as important pathways involved in processes such as delivery of "second signals" in contact hypersensitivity reactions to nickel. Nickel 277-283 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 125-129 17242515-3 2007 The nik operon in E. coli encodes a nickel-uptake system that includes the periplasmic nickel-binding protein NikA. Nickel 36-42 relaxosome component Escherichia coli 110-114 17242515-3 2007 The nik operon in E. coli encodes a nickel-uptake system that includes the periplasmic nickel-binding protein NikA. Nickel 87-93 relaxosome component Escherichia coli 110-114 17242515-4 2007 The crystal structures of wild-type NikA both bound to nickel and in the apo form have been solved previously. Nickel 55-61 relaxosome component Escherichia coli 36-40 16987991-1 2007 The sodium iodide symporter (NIS) mediates iodide (I(-)) transport in the thyroid gland and other tissues and is of increasing importance as a therapeutic target and nuclear imaging reporter. Nickel 29-32 solute carrier family 5 member 5 Rattus norvegicus 4-27 17180337-1 2007 A novel type of glassy carbon electrode modified with magnetic carbon-coated nickel nanoparticles (C-Ni/GCE) was fabricated and the electrochemical properties of brucine were studied using it. Nickel 77-83 5'-nucleotidase, cytosolic IA Homo sapiens 99-107 16973378-2 2007 Human adenylosuccinate lyase was overexpressed in Escherichia coli Rosetta 2(DE3)pLysS as an N-terminal histidine-tagged protein and was purified to homogeneity by a nickel-nitriloacetic acid column at room temperature. Nickel 166-172 adenylosuccinate lyase Homo sapiens 6-28 17898422-6 2007 Initially, using ionome analysis, it has been demonstrated that only yeast cells expressing activated CAX1 transporters have altered total calcium content and fluctuations in zinc and nickel. Nickel 184-190 cation exchanger 1 Arabidopsis thaliana 102-106 17242515-0 2007 Nickel binding to NikA: an additional binding site reconciles spectroscopy, calorimetry and crystallography. Nickel 0-6 relaxosome component Escherichia coli 18-22 17085088-8 2007 There was however a clear correlation between the surface nickel and oxygen concentration and the amount of albumin adsorbed. Nickel 58-64 albumin Homo sapiens 108-115 17085088-9 2007 Samples with higher levels of nickel and less oxygen in the surface oxide layer of the wires showed increased albumin adsorption, which could lead to improved biocompatibility. Nickel 30-36 albumin Homo sapiens 110-117 21204502-14 2007 An inorganic calcium channel blocker:for example, cobalt or nickel:also blocks the action of IGF-I on cell-cycle progression. Nickel 60-66 insulin like growth factor 1 Homo sapiens 93-98 17721644-5 2007 Treatment of nickel-stimulated peripheral blood mononuclear cells with 5x10(-5) mol/l of DOI inhibited (p <0.01) the proliferation of nickel-stimulated peripheral blood mononuclear cells, while no effect was found regarding IL-2 production. Nickel 13-19 interleukin 2 Homo sapiens 227-231 17721644-5 2007 Treatment of nickel-stimulated peripheral blood mononuclear cells with 5x10(-5) mol/l of DOI inhibited (p <0.01) the proliferation of nickel-stimulated peripheral blood mononuclear cells, while no effect was found regarding IL-2 production. Nickel 137-143 interleukin 2 Homo sapiens 227-231 17263646-2 2007 The exposure of affected individuals to nickel leads to a delayed-type hypersensitivity reaction, which is induced by antigen-specific CD4 and CD8 T cells. Nickel 40-46 CD4 molecule Homo sapiens 135-138 17263646-2 2007 The exposure of affected individuals to nickel leads to a delayed-type hypersensitivity reaction, which is induced by antigen-specific CD4 and CD8 T cells. Nickel 40-46 CD8a molecule Homo sapiens 143-146 17263646-7 2007 Data obtained with nickel-specific CD4 T cell clones showed that antigen-mediated proliferation is an absolute prerequisite for HIV expansion. Nickel 19-25 CD4 molecule Homo sapiens 35-38 17591727-1 2007 The reactions of small saturated hydrocarbons by gaseous nickel cations NiX+ (X=F, Cl, Br, I) are investigated by means of electrospray ionization mass spectrometry. Nickel 57-63 BCL2 interacting protein 3 like Homo sapiens 72-75 17176259-4 2007 The mutants (e.g. vma3, ctr1, sod1) exhibited the anticipated sensitivities to intermediate doses of nickel, copper, alkaline pH, menadione or paraquat. Nickel 101-107 H(+)-transporting V0 sector ATPase subunit c Saccharomyces cerevisiae S288C 18-22 17176259-4 2007 The mutants (e.g. vma3, ctr1, sod1) exhibited the anticipated sensitivities to intermediate doses of nickel, copper, alkaline pH, menadione or paraquat. Nickel 101-107 high-affinity Cu transporter CTR1 Saccharomyces cerevisiae S288C 24-28 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 transcobalamin 2 Homo sapiens 9-12 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interleukin 4 Homo sapiens 14-18 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interleukin 5 Homo sapiens 20-24 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interleukin 13 Homo sapiens 26-31 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 negative elongation factor complex member C/D Homo sapiens 37-40 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 transcobalamin 1 Homo sapiens 42-45 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interferon gamma Homo sapiens 47-55 18409353-9 2007 The acquisition of nickel tolerance is possibly dependent on the IL-10 secretion by specific lymphocytes. Nickel 19-25 interleukin 10 Homo sapiens 65-70 17313856-1 2006 OBJECTIVE: To investigate the effects of chronic iodine excess on thyroid function, thyroid peroxidase (TPO) activity, and expression of sodium-iodide symporter (NIS). Nickel 162-165 solute carrier family 5 member 5 Rattus norvegicus 137-160 16982623-0 2006 Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. Nickel 0-6 prostaglandin-endoperoxide synthase 2 Homo sapiens 106-122 16982623-0 2006 Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. Nickel 0-6 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 134-141 16982623-0 2006 Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. Nickel 0-6 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 142-168 16982623-0 2006 Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 174-177 16982623-3 2006 We found that exposure of Beas-2B cells to nickel compounds resulted in increased cyclooxygenase-2 (COX-2) expression and that small interfering RNA (siCOX-2) knockdown of COX-2 expression resulted in increased cell sensitivity to nickel-triggered cell apoptosis, demonstrating that COX-2 induction has an anti-apoptotic effect on Beas-2B cells. Nickel 43-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 82-98 16982623-3 2006 We found that exposure of Beas-2B cells to nickel compounds resulted in increased cyclooxygenase-2 (COX-2) expression and that small interfering RNA (siCOX-2) knockdown of COX-2 expression resulted in increased cell sensitivity to nickel-triggered cell apoptosis, demonstrating that COX-2 induction has an anti-apoptotic effect on Beas-2B cells. Nickel 43-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 100-105 16982623-4 2006 Overexpression of IKKbeta-KM, a kinase inactive mutant of IKKbeta, blocked NF-kappaB activation and COX-2 induction by nickel compounds, indicating that activated NF-kappaB may be a mediator for COX-2 induction. Nickel 119-125 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 18-25 16982623-4 2006 Overexpression of IKKbeta-KM, a kinase inactive mutant of IKKbeta, blocked NF-kappaB activation and COX-2 induction by nickel compounds, indicating that activated NF-kappaB may be a mediator for COX-2 induction. Nickel 119-125 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 58-65 16982623-4 2006 Overexpression of IKKbeta-KM, a kinase inactive mutant of IKKbeta, blocked NF-kappaB activation and COX-2 induction by nickel compounds, indicating that activated NF-kappaB may be a mediator for COX-2 induction. Nickel 119-125 prostaglandin-endoperoxide synthase 2 Homo sapiens 100-105 16982623-4 2006 Overexpression of IKKbeta-KM, a kinase inactive mutant of IKKbeta, blocked NF-kappaB activation and COX-2 induction by nickel compounds, indicating that activated NF-kappaB may be a mediator for COX-2 induction. Nickel 119-125 prostaglandin-endoperoxide synthase 2 Homo sapiens 195-200 16982623-6 2006 Loss of IKKbeta impaired COX-2 induction by nickel exposure, whereas knockout of IKKalpha had a marginal effect. Nickel 44-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 25-30 16982623-7 2006 Moreover, the NF-kappaB p65, and not the p50 subunit, was critical for nickel-induced COX-2 expression. Nickel 71-77 RELA proto-oncogene, NF-kB subunit Homo sapiens 24-27 16982623-7 2006 Moreover, the NF-kappaB p65, and not the p50 subunit, was critical for nickel-induced COX-2 expression. Nickel 71-77 prostaglandin-endoperoxide synthase 2 Homo sapiens 86-91 16982623-8 2006 In addition, a deficiency of IKKbeta or p65 rendered cells more sensitive to nickel-induced apoptosis as compared with those in wild type cells. Nickel 77-83 RELA proto-oncogene, NF-kB subunit Homo sapiens 40-43 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 62-68 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 62-68 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 93-100 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 62-68 RELA proto-oncogene, NF-kB subunit Homo sapiens 101-104 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 62-68 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 129-137 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 62-68 nuclear factor kappa B subunit 1 Homo sapiens 143-146 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 208-214 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 208-214 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 93-100 16982623-10 2006 Collectively, our results demonstrate that COX-2 induction by nickel compounds occurs via an IKKbeta/p65 NF-kappaB-dependent but IKKalpha- and p50-independent pathway and plays a crucial role in antagonizing nickel-induced cell apoptosis in Beas-2B cells. Nickel 208-214 RELA proto-oncogene, NF-kB subunit Homo sapiens 101-104 17100760-0 2006 Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 60-63 17100760-1 2006 Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 94-97 17176259-4 2007 The mutants (e.g. vma3, ctr1, sod1) exhibited the anticipated sensitivities to intermediate doses of nickel, copper, alkaline pH, menadione or paraquat. Nickel 101-107 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 30-34 17045426-7 2006 Nickel caused increased (two-fold) phosphorylation of ERK 1/2 only, and was not cytotoxic over the tested concentration range. Nickel 0-6 mitogen-activated protein kinase 3 Homo sapiens 54-61 17107012-4 2006 The association of His-PhLP with DNA-templated nickel ions or metal is reversible under appropriate rinsing conditions. Nickel 47-53 phosducin Homo sapiens 23-27 17090009-1 2006 Alkynylboration has been achieved in the reaction of alkynyl(pinacol)boranes with alkynes in the presence of nickel catalysts, giving cis-1-borylbut-1-en-3-yne derivatives. Nickel 109-115 cytokine inducible SH2 containing protein Homo sapiens 134-139 16797097-4 2006 Herein, we developed single-step nickel affinity purification of rLF with yield up to 3mg/l. Nickel 33-39 RLF zinc finger Rattus norvegicus 65-68 16877034-8 2006 If treatment with the Fe and metal ions was simultaneous (co-treatment), the effects of nickel ion exposure were overwhelmed, since the added Fe reversed HIF-1alpha stabilization, decreased IRP-1 activity, and increased ferritin level. Nickel 88-94 hypoxia inducible factor 1 subunit alpha Homo sapiens 154-164 16874470-1 2006 A series of metallopeptides based on the amino terminal copper/nickel (ATCUN) binding motif have been evaluated as classical inhibitors and catalytic inactivators of both rabbit and human angiotensin-converting enzyme (hACE), and human endothelin-converting enzyme 1 (hECE-1). Nickel 63-69 angiotensin I converting enzyme Homo sapiens 219-223 16895920-5 2006 Co-purification of Ung and Ndk through multicolumn low pressure and nickel-nitrilotriacetic acid affinity chromatography suggests that the interaction occurs in a cellular context, as was also suggested by co-immunoprecipitation of endogenous Ung and Ndk from cellular extracts. Nickel 68-74 uracil DNA glycosylase Homo sapiens 19-22 16895920-5 2006 Co-purification of Ung and Ndk through multicolumn low pressure and nickel-nitrilotriacetic acid affinity chromatography suggests that the interaction occurs in a cellular context, as was also suggested by co-immunoprecipitation of endogenous Ung and Ndk from cellular extracts. Nickel 68-74 NME/NM23 nucleoside diphosphate kinase 4 Homo sapiens 27-30 16950394-4 2006 hK4 crystallised in the presence of zinc, nickel, and cobalt ions in three crystal forms containing cyclic tetramers and octamers. Nickel 42-48 keratin 4 Homo sapiens 0-3 16724222-6 2006 The proposed methodology showed a high tolerance to the commonly encountered alkaline earth matrix elements in environmental waters, that is, calcium and magnesium, and was successfully applied for the determination of nickel in an NIST standard reference material (NIST 1640-Trace elements in natural water), household tap water of high hardness and local seawater. Nickel 219-225 nuclear RNA export factor 1 Homo sapiens 320-323 16750393-5 2006 Combining immobilized nickel affinity chromatography and gel filtration we obtained purified SycD with an exceptional yield of 120mg per liter of culture and homogeneity above 95%. Nickel 22-28 sycD Yersinia enterocolitica 93-97 16581223-7 2006 Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 70-75 16581223-7 2006 Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 155-160 16581223-7 2006 Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production. Nickel 95-101 matrix metallopeptidase 2 Homo sapiens 70-75 16790430-0 2006 AtIREG2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in Arabidopsis thaliana roots. Nickel 73-79 iron regulated 2 Arabidopsis thaliana 0-7 16790430-8 2006 Transgenic plants overexpressing AtIREG2 showed an increased tolerance to elevated concentrations of nickel, whereas T-DNA insertion lines lacking AtIREG2 expression were more sensitive to nickel, particularly under iron deficiency, and accumulated less nickel in roots. Nickel 101-107 iron regulated 2 Arabidopsis thaliana 33-40 16790430-9 2006 We therefore propose a role of AtIREG2 in vacuolar loading of nickel under iron deficiency and thus identify it as a novel component in the iron deficiency stress response. Nickel 62-68 iron regulated 2 Arabidopsis thaliana 31-38 17050123-2 2006 This method is based on immobilizing scFv fragments via their C-terminal hexahistidyl-tag on liposomes containing nickel-complexed dioleoyl-glycero-succinyl-nitrilotriacetic acid (Ni-NTA-DOGS) as an anchor lipid within the lipid bilayer. Nickel 114-120 immunglobulin heavy chain variable region Homo sapiens 37-41 16584717-0 2006 NIS/TFA: a general method for hydrolyzing thioglycosides. Nickel 0-3 coagulation factor III, tissue factor Homo sapiens 4-7 16682227-5 2006 The refolded protein was purified by nickel affinity chromatography due to an N-terminal polyhistidine tag which can be cleaved with thrombin subsequently. Nickel 37-43 coagulation factor II, thrombin Homo sapiens 133-141 16931295-0 2006 Amperometric detection of insulin at renewable sol-gel derived carbon ceramic electrode modified with nickel powder and potassium octacyanomolybdate(IV). Nickel 102-108 insulin Homo sapiens 26-33 16490247-4 2006 RET was purified by a two-step procedure consisting of an anion exchange chromatography followed by nickel affinity chromatography. Nickel 100-106 ret proto-oncogene Homo sapiens 0-3 16863591-3 2006 PRESENTATION OF THE HYPOTHESIS: Cobalt, a naturally-occurring element with properties similar to those of iron and nickel, induces a marked and stable polycythemic response through a more efficient transcription of the erythropoietin gene. Nickel 115-121 erythropoietin Homo sapiens 219-233 16730657-4 2006 In this study, using breast cancer cell lines, we established that tRA-responsive NIS expression is confined to estrogen receptor-alpha (ERalpha) positive cells and we investigated the role of ERalpha in the regulation of NIS expression. Nickel 82-85 estrogen receptor 1 Homo sapiens 112-135 16730657-4 2006 In this study, using breast cancer cell lines, we established that tRA-responsive NIS expression is confined to estrogen receptor-alpha (ERalpha) positive cells and we investigated the role of ERalpha in the regulation of NIS expression. Nickel 82-85 estrogen receptor 1 Homo sapiens 137-144 16730657-5 2006 We showed that the suppression of endogenous ERalpha by RNA interference downregulates NIS expression in ERalpha positive mammary cells. Nickel 87-90 estrogen receptor 1 Homo sapiens 45-52 16730657-5 2006 We showed that the suppression of endogenous ERalpha by RNA interference downregulates NIS expression in ERalpha positive mammary cells. Nickel 87-90 estrogen receptor 1 Homo sapiens 105-112 16730657-6 2006 Besides, in an ERalpha negative cell line, reintroduction of ERalpha resulted in the expression of NIS in a ligand-independent manner. Nickel 99-102 estrogen receptor 1 Homo sapiens 15-22 16730657-6 2006 Besides, in an ERalpha negative cell line, reintroduction of ERalpha resulted in the expression of NIS in a ligand-independent manner. Nickel 99-102 estrogen receptor 1 Homo sapiens 61-68 16518850-5 2006 Recombinant cytochrome c oxidase solubilized in detergent is immobilized on a chemically modified gold surface via the affinity of its histidine (His)-tag to a nickel-chelating nitro-triacetic acid (NTA) surface. Nickel 160-166 cytochrome c, somatic Homo sapiens 12-24 16828895-2 2006 Various SOD enzymes have been characterized that employ either a copper, manganese, iron or nickel co-factor to carry out the disproportionation of superoxide. Nickel 92-98 superoxide dismutase 1 Homo sapiens 8-11 16837620-1 2006 The uptake of iodide represents the first step in thyroid hormone synthesis by thyroid follicular cells and is mediated by the sodium-iodide symporter (NIS). Nickel 152-155 solute carrier family 5 member 5 L homeolog Xenopus laevis 127-150 16649251-2 2006 One major consequence of exposure to nickel is the stabilization of hypoxia inducible factor-1alpha (HIF-1alpha), a protein known to be overexpressed in a variety of cancers. Nickel 37-43 hypoxia inducible factor 1 subunit alpha Homo sapiens 68-99 16649251-2 2006 One major consequence of exposure to nickel is the stabilization of hypoxia inducible factor-1alpha (HIF-1alpha), a protein known to be overexpressed in a variety of cancers. Nickel 37-43 hypoxia inducible factor 1 subunit alpha Homo sapiens 101-111 16649251-3 2006 In this study, we report a persistent stabilization of HIF-1alpha by nickel chloride up to 72 h after the removal of nickel from the culture media. Nickel 69-75 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-65 16649251-8 2006 Understanding the mechanisms by which nickel can inhibit HIF-PHD"s and stabilize HIF-1alpha may be important in the treatment of cancer and ischemic diseases. Nickel 38-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 81-91 16806017-8 2006 The purity of scFv C1 by nickel-agarose column was above 95% and its yield was about 0.8 mg/L. Nickel 25-31 immunglobulin heavy chain variable region Homo sapiens 14-18 16787073-1 2006 Nickel complexes having a bulky tri(sec-alkyl)phosphine ligand catalyze hydroheteroarylation of alkynes at 35 degrees C. Selective activation of an Ar-H bond over an Ar-CN bond of N-protected 3-cyanoindoles is achieved by a proper choice of ligand and/or an N-protecting group. Nickel 0-6 low density lipoprotein receptor adaptor protein 1 Homo sapiens 148-152 16779580-7 2006 Site soils contained very high aluminium concentrations, but metal contamination was restricted to one soil sample from API 1, which contained nickel above threshold limits. Nickel 143-149 baculoviral IAP repeat containing 2 Homo sapiens 120-125 17044645-0 2006 Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells. Nickel 41-47 fragile histidine triad diadenosine triphosphatase Homo sapiens 15-19 17044645-0 2006 Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells. Nickel 41-47 cyclin dependent kinase inhibitor 2A Homo sapiens 29-32 17044645-11 2006 Alterations of the FHIT gene induced by crystalline NiS may be a molecular event associated with carcinogen, chromosome fragile site instability and cell malignant transformation. Nickel 52-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 19-23 17044645-12 2006 FHIT may be an important target gene activated by nickel and other exotic carcinogens. Nickel 50-56 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 16778198-1 2006 Cap43 has been identified as a nickel- and calcium-induced gene, and is also known as N-myc downstream-regulated gene 1 (NDRG1), Drg-1 and rit42. Nickel 31-37 N-myc downstream regulated 1 Homo sapiens 0-5 16749844-0 2006 Molybdenum and tungsten eta2-alkyne-1-thio complexes acting as sulfur donors in homoleptic Werner type complexes with nickel(II) and palladium(II). Nickel 118-124 DNA polymerase iota Homo sapiens 24-28 16752921-12 2006 The soluble human E-NTPDase 8 which was secreted into the culture media of transfected HEK293 cells was purified by ammonium sulfate fractionation and nickel affinity chromatography. Nickel 151-157 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 18-29 16756300-3 2006 The side chains of residues His1, Cys2, and Cys6, which are essential for nickel binding and catalysis, were modeled explicitly. Nickel 74-80 viral integration site 1 Homo sapiens 28-32 16734437-1 2006 Allyl cyanides are found to add across alkynes in the presence of a nickel catalyst prepared from Ni(cod)2 and P(4-CF3-C6H4)3 in situ to give variously functionalized di- or trisubstituted acrylonitriles in highly stereoselective manners possibly via a pi-allylnickel species as an intermediate. Nickel 68-74 COD2 Homo sapiens 98-106 16735468-8 2006 Although it now seems reasonable that Sco1, which is characterized by a thioredoxin fold, has evolved to bind a metal atom via the di-Cys motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin function. Nickel 199-205 synthesis of cytochrome C oxidase 1 Homo sapiens 38-42 16735468-8 2006 Although it now seems reasonable that Sco1, which is characterized by a thioredoxin fold, has evolved to bind a metal atom via the di-Cys motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin function. Nickel 199-205 thioredoxin Homo sapiens 72-83 16735468-8 2006 Although it now seems reasonable that Sco1, which is characterized by a thioredoxin fold, has evolved to bind a metal atom via the di-Cys motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin function. Nickel 199-205 thioredoxin Homo sapiens 259-270 16651871-5 2006 Mature alpha(2)AP was expressed as a hexahistidine-tagged recombinant protein in Escherichia coli, purified by nickel-chelate affinity and ion exchange chromatography, and its reaction with plasmin and soluble fibrin assessed electrophoretically and compared with an analogous recombinant human alpha(2)AP. Nickel 111-117 alpha-2-antiplasmin Oryctolagus cuniculus 7-17 16776574-5 2006 Previous studies from this laboratory reported mucin-1 (MUC1)-driven expression of NIS in cancer cells. Nickel 83-86 mucin 1, transmembrane Mus musculus 47-54 16776574-5 2006 Previous studies from this laboratory reported mucin-1 (MUC1)-driven expression of NIS in cancer cells. Nickel 83-86 mucin 1, transmembrane Mus musculus 56-60 16426630-1 2006 Isothermal calorimetry was used to determine enthalpy changes for interaction of divalent cobalt, nickel, copper, and zinc chlorides with silica gel functionalized with vanillin, Sil-Van. Nickel 98-104 STIL centriolar assembly protein Homo sapiens 179-182 16600631-4 2006 The highest level of expression was found in Rosetta (DE3) with a C-terminal construct after induction at 37 degrees C. The purification scheme was elucidated using SELDI-MS: S-LAT was efficiently captured on an IMAC ProteinChip array saturated with nickel ions (Ni(2+)) and then fractionated on a Q ProteinChip array. Nickel 250-256 linker for activation of T cells Mus musculus 177-180 16707596-1 2006 PURPOSE: Cap43 is known as a nickel- and calcium-inducible gene. Nickel 29-35 N-myc downstream regulated 1 Homo sapiens 9-14 16706840-3 2006 MPOs were dependent on CaV3.3 channel activity given that they were recorded from a potential range of -55 to -70 mV, blocked by nickel and mibefradil, as well as by low external Ca2+ concentration. Nickel 129-135 calcium channel, voltage-dependent, alpha 1I subunit Mus musculus 23-29 16648469-1 2006 We have previously reported that carcinogenic nickel compounds decreased global histone H4 acetylation and silenced the gpt transgene in G12 Chinese hamster cells. Nickel 46-52 glutamic--pyruvic transaminase Homo sapiens 120-123 16648469-7 2006 Exposure to nickel ions also increased H3K9 dimethylation at the gpt locus in G12 cells and repressed the expression of the gpt transgene. Nickel 12-18 glutamic--pyruvic transaminase Homo sapiens 65-68 16648469-7 2006 Exposure to nickel ions also increased H3K9 dimethylation at the gpt locus in G12 cells and repressed the expression of the gpt transgene. Nickel 12-18 glutamic--pyruvic transaminase Homo sapiens 124-127 16648469-8 2006 An extended nickel ion exposure led to increased frequency of the gpt transgene silencing, which was readily reversed by treatment with DNA-demethylating agent 5-aza-2"-deoxycytidine. Nickel 12-18 glutamic--pyruvic transaminase Homo sapiens 66-69 16677309-8 2006 Furthermore, a five-protein complex consisting of FliG, His-tagged FliM, FliN, FliH and FliI was purified by nickel-affinity chromatography. Nickel 109-115 FLII actin remodeling protein Homo sapiens 88-92 16482361-1 2006 A series of cationic pyridinylidene and quinolinylidene complexes of chlorobis(triphenylphosphine)-nickel(II) were prepared by oxidative substitution of Ni(PPh3)4 with methylated chloropyridines or chloroquinolines. Nickel 99-105 caveolin 1 Homo sapiens 156-160 16626117-1 2006 Highly substituted 1H-isochromenes, isobenzofurans, and pyranopyridines can be prepared by allowing o-(1-alkynyl)arenecarboxaldehydes and ketones to react with I2, ICl, NIS, Br2, NBS, p-O2NC6H4SCl, or PhSeBr and various alcohols or carbon-based nucleophiles at room temperature. Nickel 169-172 nibrin Homo sapiens 179-182 16585548-3 2006 In this study, we report that oral nickel administration increased the nickel content of splenic Ni(high) B cells and up-regulated their Fas expression while down-regulating expression of bcl-2 and Bcl-xL, thus giving rise to an Ag-carrying, apoptosis-prone B cell phenotype. Nickel 35-41 B cell leukemia/lymphoma 2 Mus musculus 188-193 16585548-3 2006 In this study, we report that oral nickel administration increased the nickel content of splenic Ni(high) B cells and up-regulated their Fas expression while down-regulating expression of bcl-2 and Bcl-xL, thus giving rise to an Ag-carrying, apoptosis-prone B cell phenotype. Nickel 35-41 BCL2-like 1 Mus musculus 198-204 16633658-1 2006 The evolution of nickel speciation during the successive preparation steps of Ni-SiO(2) catalysts is studied by UV-Vis-NIR, FT-IR, DTG, TPR and TEM. Nickel 17-23 translocated promoter region, nuclear basket protein Homo sapiens 136-139 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 carbonic anhydrase 9 Homo sapiens 101-122 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 carbonic anhydrase 9 Homo sapiens 124-129 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 N-myc downstream regulated 1 Homo sapiens 135-140 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 N-myc downstream regulated 1 Homo sapiens 141-146 16288478-5 2006 Nickel exposure caused strong activation of HIF-1alpha and HIF-2alpha proteins, underscoring activation of HIF-1-dependent transcription. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 44-49 16288478-8 2006 The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Nickel 115-121 carbonic anhydrase 9 Homo sapiens 67-72 16288478-8 2006 The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Nickel 115-121 N-myc downstream regulated 1 Homo sapiens 77-82 16288478-8 2006 The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Nickel 115-121 N-myc downstream regulated 1 Homo sapiens 83-88 16288478-10 2006 Ascorbate is delivered to lung cells via the SVCT2 ascorbate transporter, which was found to be sensitive to nickel or cell density. Nickel 109-115 solute carrier family 23 member 2 Homo sapiens 45-50 16547066-3 2006 The Mm2058 protein was expressed with a decahistidine tag at its N terminus and was purified to homogeneity using nickel affinity chromatography. Nickel 114-120 alpha-ribazole phosphatase CobZ Methanosarcina mazei Go1 4-10 16430917-1 2006 The vinculin binding site on alpha-actinin was determined by cryo-electron microscopy of 2D arrays formed on phospholipid monolayers doped with a nickel chelating lipid. Nickel 146-152 vinculin Gallus gallus 4-12 16430917-1 2006 The vinculin binding site on alpha-actinin was determined by cryo-electron microscopy of 2D arrays formed on phospholipid monolayers doped with a nickel chelating lipid. Nickel 146-152 actinin, alpha 4 Gallus gallus 29-42 16533060-5 2006 We now report full restoration of biological activity to the isolated tissue factor ectodomain via the engineering of a hexahistidine tag onto its C-terminus and its use in combination with membrane bilayers containing nickel-chelating lipids. Nickel 219-225 coagulation factor III, tissue factor Homo sapiens 70-83 16497011-2 2006 Air-stable Ni(PPh3)2Cl2 has also been established as catalyst precursor, and highly active nickel catalysts were obtained when the reduction of Ni(PPh3)2Cl2 with n-BuLi was carried out in the presence of an aryl chloride. Nickel 91-97 caveolin 1 Homo sapiens 14-18 16497011-2 2006 Air-stable Ni(PPh3)2Cl2 has also been established as catalyst precursor, and highly active nickel catalysts were obtained when the reduction of Ni(PPh3)2Cl2 with n-BuLi was carried out in the presence of an aryl chloride. Nickel 91-97 caveolin 1 Homo sapiens 147-151 16377633-0 2006 A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels. Nickel 27-33 calcium voltage-gated channel subunit alpha1 H Homo sapiens 48-54 16487249-0 2006 Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Nickel 0-6 interleukin 10 Homo sapiens 15-20 16487249-0 2006 Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 36-39 16487249-0 2006 Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Nickel 101-107 interleukin 10 Homo sapiens 15-20 16487249-0 2006 Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Nickel 101-107 negative elongation factor complex member C/D Homo sapiens 36-39 16514173-3 2006 Active (driven by Na(+)/K(+)-ATPase) iodide transport into thyroid follicular cells is mediated by the sodium-iodide symporter (NIS), which is also abundantly expressed in gastric mucosa. Nickel 128-131 solute carrier family 5 member 5 Rattus norvegicus 103-126 16377633-2 2006 From pharmacological analysis of the recombinant T-type channels, low concentrations (<50 microM) of nickel were found to selectively block the Ca(v)3.2 over the other isoforms. Nickel 104-110 immunoglobulin lambda variable 7-43 Homo sapiens 147-155 16377633-3 2006 To date, however, the structural element(s) responsible for the nickel block on the Ca(v)3.2 T-type Ca2+ channel remain unknown. Nickel 64-70 immunoglobulin lambda variable 7-43 Homo sapiens 84-92 16377633-4 2006 Thus, we constructed chimeric channels between the nickel-sensitive Ca(v)3.2 and the nickel-insensitive Ca(v)3.1 to localize the region interacting with nickel. Nickel 51-57 immunoglobulin lambda variable 7-43 Homo sapiens 68-76 16377633-5 2006 Systematic assaying of serial chimeras suggests that the region preceding domain I S4 of Ca(v)3.2 contributes to nickel block. Nickel 113-119 immunoglobulin lambda variable 7-43 Homo sapiens 89-97 16377633-6 2006 Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. Nickel 29-35 immunoglobulin lambda variable 7-43 Homo sapiens 149-157 16377633-6 2006 Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. Nickel 29-35 calcium voltage-gated channel subunit alpha1 G Homo sapiens 212-220 16377633-6 2006 Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. Nickel 133-139 immunoglobulin lambda variable 7-43 Homo sapiens 149-157 16377633-6 2006 Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. Nickel 133-139 immunoglobulin lambda variable 7-43 Homo sapiens 149-157 16377633-7 2006 These findings indicate that His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 and reveal a novel role for the S3-S4 loop to control ion permeation through T-type Ca2+ channels. Nickel 88-94 immunoglobulin lambda variable 7-43 Homo sapiens 104-112 16166738-6 2006 Gene-targeted Mt1/2(-/-) mice were more susceptible than Mt1/2(+/+) mice to nickel-induced inflammation, surfactant-associated protein B transcript loss, and lethality. Nickel 76-82 metallothionein 1 Mus musculus 14-19 16430697-2 2006 In Leishmania major, the first step in methylglyoxal detoxification is performed by a trypanothione-dependent glyoxalase I (GLO1) containing a nickel cofactor; all other characterized eukaryotic glyoxalases use zinc. Nickel 143-149 glyoxalase I Homo sapiens 124-128 16430697-5 2006 The crystal structure of L. major GLO1 reveals differences in active site architecture to both human GLO1 and the nickel-dependent Escherichia coli GLO1, including increased negative charge and hydrophobic character and truncation of a loop that may regulate catalysis in the human enzyme. Nickel 114-120 glyoxalase I Homo sapiens 34-38 16308346-5 2006 5,6-EET-induced Ca(2+) entry was sensitive to the CCE blockers 2-APB, lanthanum, SKF-96365 and nickel and impaired by incubation with anti-hTRPC1 antibody. Nickel 95-101 transient receptor potential cation channel subfamily C member 1 Homo sapiens 139-145 16166746-0 2006 Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Nickel 56-62 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Mus musculus 28-33 16166746-1 2006 Previous studies have shown that mice deficient in the tyrosine kinase domain (TK-/-) of the receptor Mst1r have an increased susceptibility to nickel (Ni)-induced acute lung injury (ALI). Nickel 144-150 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Mus musculus 102-107 16052231-3 2006 Pre-incubation of the NIS/TPO-modified NSCLC cells in iodide followed by ionizing radiation generates bystander tumoricidal effects and potently enhances tumor cell killing. Nickel 22-25 thyroid peroxidase Homo sapiens 26-29 16384965-5 2006 Recombinant myocilin was purified from the media using nickel ion affinity chromatography. Nickel 55-61 myocilin Homo sapiens 12-20 17046388-5 2006 Purification of different length ataxin-3 variants, including one of pathological length, is facilitated by an N-terminal hexa-histidine tag, which enables binding to a nickel-chelated agarose resin. Nickel 169-175 ataxin 3 Homo sapiens 33-41 17458092-1 2006 PURPOSE: Considering nickel release from fixed orthodontic appliances, determination of the relationship between the clinical status of the mouth, IgE level and treatment duration in orthodontic patients seems to be advisable. Nickel 21-27 immunoglobulin heavy constant epsilon Homo sapiens 147-150 16538437-6 2006 In addition, chronic application of 30 microM nickel, known to inhibit T-type Ca(V)3.2 channels, did not alter the fusion of C2C12 cells and mouse satellite cells in primary culture. Nickel 46-52 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 71-86 17642139-11 2006 The concentration of IFNgamma in supernatants from stimulated as well as non-stimulated cells from patients with contact allergy to nickel was higher in comparison to the control group. Nickel 132-138 interferon gamma Homo sapiens 21-29 17642139-13 2006 There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel. Nickel 122-128 interferon gamma Homo sapiens 43-51 17642139-13 2006 There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel. Nickel 122-128 interleukin 5 Homo sapiens 56-60 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 95-101 interferon gamma Homo sapiens 9-17 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 195-201 interferon gamma Homo sapiens 107-115 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 195-201 interleukin 5 Homo sapiens 127-131 16406803-7 2005 The resulting recombinant PGIS associates with host cell membranes and was purified to electrophoretic homogeneity by nickel affinity, hydroxyapatite and CM Sepharose column chromatography. Nickel 118-124 prostaglandin I2 synthase Homo sapiens 26-30 16009382-6 2005 A similar effect was found in yeast cells where nickel was able to silence the URA-3 gene placed near (1.3 kb) a telomere silencing element, but not when the gene was placed farther away from the silencing element (2.0 kb). Nickel 48-54 orotidine-5'-phosphate decarboxylase Saccharomyces cerevisiae S288C 79-84 16351103-6 2005 Our thiolate sulfur and nickel EPR data prove a Ni-S coordination, with an unpaired spin density on the sulfur of 7 +/- 3%. Nickel 24-30 solute carrier family 5 member 5 Homo sapiens 48-52 16363845-3 2005 The preparation, electrochemical properties, and X-ray crystal structures of the square-planar nickel complexes, in both their dianionic diamagnetic [Ni(tfadt)(2)](2)(-) and their monoanionic paramagnetic [Ni(tfadt)(2)](*)(-) forms, are reported, as n-Bu(4)N(+), PPh(4)(+), and (18-crown-6)Na(+) salts, respectively. Nickel 95-101 potassium two pore domain channel subfamily K member 3 Homo sapiens 263-269 16100012-6 2005 TGF-beta1 protein in bronchoalveolar lavage fluid, as well as the effect of inhibition of TGF-beta, was assessed in nickel-exposed mice. Nickel 116-122 transforming growth factor, beta 1 Mus musculus 0-9 16100012-6 2005 TGF-beta1 protein in bronchoalveolar lavage fluid, as well as the effect of inhibition of TGF-beta, was assessed in nickel-exposed mice. Nickel 116-122 transforming growth factor, beta 1 Mus musculus 0-8 16100012-8 2005 MEASUREMENTS AND MAIN RESULTS: Genes that decreased the most after nickel exposure play important roles in lung fluid absorption or surfactant and phospholipid synthesis, and genes that increased the most were involved in TGF-beta signaling. Nickel 67-73 transforming growth factor, beta 1 Mus musculus 222-230 16100012-10 2005 TGF-beta-inducible genes involved in the regulation of extracellular matrix function and fibrinolysis were significantly increased after nickel exposure, and TGF-beta1 protein was also increased in the lavage fluid. Nickel 137-143 transforming growth factor, beta 1 Mus musculus 0-8 16100012-11 2005 Pharmacologic inhibition of TGF-beta attenuated nickel-induced protein in bronchoalveolar lavage. Nickel 48-54 transforming growth factor, beta 1 Mus musculus 28-36 16229046-0 2005 Efficient aryl-(hetero)aryl coupling by activation of C-Cl and C-F bonds using nickel complexes of air-stable phosphine oxides. Nickel 79-85 crystallin gamma C Homo sapiens 54-58 16256202-0 2005 Structural and functional implications of the hexokinase-nickel interaction. Nickel 57-63 hexokinase Saccharomyces cerevisiae S288C 46-56 16256202-1 2005 The interaction between nickel and yeast hexokinase was studied. Nickel 24-30 hexokinase Saccharomyces cerevisiae S288C 41-51 16300400-4 2005 Purification of recombinant hSGLT1 by nickel-affinity chromatography yields about 3 mg of purified recombinant hSGLT1 per 1-liter of cultured Pichia cells. Nickel 38-44 solute carrier family 5 member 1 Homo sapiens 28-34 16300400-4 2005 Purification of recombinant hSGLT1 by nickel-affinity chromatography yields about 3 mg of purified recombinant hSGLT1 per 1-liter of cultured Pichia cells. Nickel 38-44 solute carrier family 5 member 1 Homo sapiens 111-117 16169847-7 2005 Using a gold-labeled nickel-nitrilotriacetic acid probe, the polypeptides of the p43 dimer have been located along one face of the particle. Nickel 21-27 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Homo sapiens 81-84 16283513-0 2005 Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression. Nickel 61-67 vascular endothelial growth factor A Homo sapiens 76-80 21783632-6 2005 We considered prolidase as a potential target for nickel-dependent collagen biosynthesis regulation. Nickel 50-56 peptidase D Homo sapiens 14-23 21783632-10 2005 It suggests that acetylsalicylic acid prevents nickel-induced increase in collagen biosynthesis through inhibition of prolidase activity in human fibroblasts. Nickel 47-53 peptidase D Homo sapiens 118-127 16283513-3 2005 Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. Nickel 36-42 vascular endothelial growth factor A Homo sapiens 82-116 16283513-3 2005 Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. Nickel 36-42 vascular endothelial growth factor A Homo sapiens 118-122 16283513-4 2005 In the present study, we investigated the potential roles of PI-3K, ERKs, p38 kinase and calcium signalling in VEGF induction by nickel in Cl 41 cells. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 111-115 16283513-5 2005 Exposure of Cl 41 cells to nickel compounds led to VEGF induction in both time- and dose-dependent manners. Nickel 27-33 vascular endothelial growth factor A Homo sapiens 51-55 16283513-6 2005 Pre-treatment of Cl 41 cells with PI-3K inhibitor, wortmannin or Ly294002, resulted in a striking inhibition of VEGF induction by nickel compounds, implicating the role of PI-3K in the induction. Nickel 130-136 vascular endothelial growth factor A Homo sapiens 112-116 16283513-9 2005 Pre-treatment of Cl 41 cells with intracellular calcium chelator, but not calcium channel blocker, inhibited VEGF induction by nickel. Nickel 127-133 vascular endothelial growth factor A Homo sapiens 109-113 16283513-10 2005 Collectively these data demonstrate that PI-3K, ERKs and cytosolic calcium, but not p38 kinase, play essential roles in VEGF induction by nickel compounds. Nickel 138-144 vascular endothelial growth factor A Homo sapiens 120-124 16371319-3 2005 We have studied the effect of two toxic metals, lead [Pb(II)] and nickel [Ni(II)] on recombinant NR1a-NR2A and NR1a-NR2B channels expressed in RNA-injected Xenopus laevis oocytes or in transiently transfected mammalian HEK293 cells. Nickel 66-72 nodal homolog 1 L homeolog Xenopus laevis 97-101 16371319-3 2005 We have studied the effect of two toxic metals, lead [Pb(II)] and nickel [Ni(II)] on recombinant NR1a-NR2A and NR1a-NR2B channels expressed in RNA-injected Xenopus laevis oocytes or in transiently transfected mammalian HEK293 cells. Nickel 66-72 glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog Xenopus laevis 102-106 16371319-3 2005 We have studied the effect of two toxic metals, lead [Pb(II)] and nickel [Ni(II)] on recombinant NR1a-NR2A and NR1a-NR2B channels expressed in RNA-injected Xenopus laevis oocytes or in transiently transfected mammalian HEK293 cells. Nickel 66-72 nodal homolog 1 L homeolog Xenopus laevis 111-115 16371319-3 2005 We have studied the effect of two toxic metals, lead [Pb(II)] and nickel [Ni(II)] on recombinant NR1a-NR2A and NR1a-NR2B channels expressed in RNA-injected Xenopus laevis oocytes or in transiently transfected mammalian HEK293 cells. Nickel 66-72 glutamate receptor ionotropic, NMDA 2B Xenopus laevis 116-120 16244137-1 2005 Urease is a nickel-containing urea hydrolase involved in nitrogen recycling from ureide, purine, and arginine catabolism in plants. Nickel 12-18 urease Arabidopsis thaliana 0-6 16244137-2 2005 The process of urease activation by incorporation of nickel into the active site is a prime example of chaperone-mediated metal transfer to an enzyme. Nickel 53-59 urease Arabidopsis thaliana 15-21 16190722-8 2005 With CNF-O, nickel ion adsorption took place right from the start of the deposition process at pH = 3.5, and at pH = 5.6 already 4 wt % nickel was adsorbed. Nickel 12-18 NPHS1 adhesion molecule, nephrin Homo sapiens 5-8 16190722-8 2005 With CNF-O, nickel ion adsorption took place right from the start of the deposition process at pH = 3.5, and at pH = 5.6 already 4 wt % nickel was adsorbed. Nickel 136-142 NPHS1 adhesion molecule, nephrin Homo sapiens 5-8 16190722-11 2005 After reduction at 773 K in hydrogen the Ni/CNF-O contained metallic nickel particles of 8 nm homogeneously distributed over the fibers. Nickel 69-75 NPHS1 adhesion molecule, nephrin Homo sapiens 44-47 15866766-8 2005 Nickel depletes intracellular ascorbate, which leads to the inhibition of cellular hydroxylases, manifested by the loss of hypoxia-inducible factor (HIF)-1alpha and -2alpha hydroxylation and hypoxia-like stress. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 123-172 16283525-3 2005 Here we verify the ability of nickel to enter the cell via the divalent metal ion transporter 1 (DMT1) and disturb cellular iron homeostasis. Nickel 30-36 solute carrier family 11 member 2 Homo sapiens 63-95 16283525-3 2005 Here we verify the ability of nickel to enter the cell via the divalent metal ion transporter 1 (DMT1) and disturb cellular iron homeostasis. Nickel 30-36 solute carrier family 11 member 2 Homo sapiens 97-101 16283525-4 2005 Nickel may interfere with iron at both an extracellular level, by preventing iron from being transported into the cell, and at an intracellular level, by competing for iron sites on enzymes like the prolyl hydroxylases that modify hypoxia inducible factor-1alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 231-262 16283525-4 2005 Nickel may interfere with iron at both an extracellular level, by preventing iron from being transported into the cell, and at an intracellular level, by competing for iron sites on enzymes like the prolyl hydroxylases that modify hypoxia inducible factor-1alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 264-274 16283525-5 2005 Nickel was able to decrease the binding of the Von Hippel-Lindau (VHL) protein to HIF-1alpha, indicating a decrease in prolyl hydroxylase activity. Nickel 0-6 von Hippel-Lindau tumor suppressor Homo sapiens 47-64 16283525-5 2005 Nickel was able to decrease the binding of the Von Hippel-Lindau (VHL) protein to HIF-1alpha, indicating a decrease in prolyl hydroxylase activity. Nickel 0-6 von Hippel-Lindau tumor suppressor Homo sapiens 66-69 16283525-5 2005 Nickel was able to decrease the binding of the Von Hippel-Lindau (VHL) protein to HIF-1alpha, indicating a decrease in prolyl hydroxylase activity. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-92 16283525-7 2005 In addition, understanding the mechanisms by which nickel activates the HIF-1alpha pathway may lead to new molecular targets in fighting cancer. Nickel 51-57 hypoxia inducible factor 1 subunit alpha Homo sapiens 72-82 16159269-0 2005 AlMe3-promoted oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0). Nickel 71-77 DNA polymerase iota Homo sapiens 40-44 16159269-0 2005 AlMe3-promoted oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0). Nickel 71-77 DNA polymerase iota Homo sapiens 56-60 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 78-84 DNA polymerase iota Homo sapiens 47-51 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 78-84 DNA polymerase iota Homo sapiens 63-67 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 110-116 DNA polymerase iota Homo sapiens 47-51 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 110-116 DNA polymerase iota Homo sapiens 63-67 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 110-116 DNA polymerase iota Homo sapiens 47-51 16159269-2 2005 AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone. Nickel 110-116 DNA polymerase iota Homo sapiens 63-67 16158293-4 2005 The selected scFv-B2 was expressed in soluble form in Escherichia coli DH5alpha F" and purified by His-bond nickel affinity chromatography with a yield of about 1-2 mg of antibody in 1 L of the culture supernatant. Nickel 108-114 immunglobulin heavy chain variable region Homo sapiens 13-17 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Nickel 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-14 2005 Under these conditions, the results indicate that with the exception of nickel, all tested metals significantly inhibit AChE activity. Nickel 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 19003060-4 2005 CHO-S cells were selected to stably express full-length recombinant human uPA containing a hexahistidine tag at its C-terminus to permit purification by nickel-based affinity chromatography. Nickel 153-159 plasminogen activator, urokinase Homo sapiens 74-77 15919754-11 2005 Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Nickel 15-18 lysine acetyltransferase 2B Homo sapiens 102-106 15919754-11 2005 Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Nickel 15-18 E1A binding protein p300 Homo sapiens 111-115 16179016-0 2005 Nickel elicits concomitant and correlated in vitro production of Th1-, Th2-type and regulatory cytokines in subjects with contact allergy to nickel. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 65-68 16179016-0 2005 Nickel elicits concomitant and correlated in vitro production of Th1-, Th2-type and regulatory cytokines in subjects with contact allergy to nickel. Nickel 141-147 negative elongation factor complex member C/D Homo sapiens 65-68 16039939-0 2005 Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Nickel 0-6 aconitase 1 Homo sapiens 73-98 16039939-1 2005 Nickel (Ni) compounds are well-established carcinogens and are known to initiate a hypoxic response in cells via the stabilization and transactivation of hypoxia-inducible factor-1 alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 154-186 16039939-1 2005 Nickel (Ni) compounds are well-established carcinogens and are known to initiate a hypoxic response in cells via the stabilization and transactivation of hypoxia-inducible factor-1 alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 188-198 16039939-6 2005 The increased activity of iron-regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor (Tfr) mRNA and antagonized the iron-induced ferritin light chain protein synthesis. Nickel 58-64 aconitase 1 Homo sapiens 26-51 16039939-6 2005 The increased activity of iron-regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor (Tfr) mRNA and antagonized the iron-induced ferritin light chain protein synthesis. Nickel 58-64 transferrin receptor Homo sapiens 99-119 16039939-6 2005 The increased activity of iron-regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor (Tfr) mRNA and antagonized the iron-induced ferritin light chain protein synthesis. Nickel 58-64 transferrin receptor Homo sapiens 121-124 16039939-8 2005 Exposure of A549 cells to soluble nickel decreased total cellular iron by about 40%, a decrease that likely caused the observed decrease in aconitase activity and the increase of iron-regulatory protein 1 activity. Nickel 34-40 aconitase 1 Homo sapiens 179-204 16039939-9 2005 Iron treatment reversed the effect of nickel on cytosolic aconitase and iron-regulatory protein 1. Nickel 38-44 aconitase 1 Homo sapiens 72-97 16039939-11 2005 The inhibition data suggest that nickel can enter via DMT1 and compete with iron for entry into the cell. Nickel 33-39 solute carrier family 11 member 2 Homo sapiens 54-58 15967202-0 2005 Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines. Nickel 89-95 ect2 oncogene Mus musculus 21-25 15967202-0 2005 Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines. Nickel 89-95 ect2 oncogene Mus musculus 64-68 15967202-10 2005 Binding of nickel ions to enzymes of DNA synthesis likely caused amplification of the Ect2 gene. Nickel 11-17 ect2 oncogene Mus musculus 86-90 15967202-12 2005 Over-expression of Ect2 protein is a useful biomarker to detect exposure to nickel compounds and nickel ion-induced morphological and neoplastic cell transformation. Nickel 76-82 ect2 oncogene Mus musculus 19-23 15967202-12 2005 Over-expression of Ect2 protein is a useful biomarker to detect exposure to nickel compounds and nickel ion-induced morphological and neoplastic cell transformation. Nickel 97-103 ect2 oncogene Mus musculus 19-23 16033398-0 2005 Regulation of nickel-induced T-cell responsiveness by CD4+CD25+ cells in contact allergic patients and healthy individuals. Nickel 14-20 CD4 molecule Homo sapiens 54-57 16033398-1 2005 In this study, we investigated the capacity of CD4+CD25+ regulatory T cells to suppress nickel-specific effector T cells, both in nickel-allergic patients and healthy controls. Nickel 88-94 CD4 molecule Homo sapiens 47-50 16033398-2 2005 CD4+ cells isolated from allergic patients showed an increased proliferative response to nickel, whereas CD4+ cells from negative controls did not respond to allergen. Nickel 89-95 CD4 molecule Homo sapiens 0-3 16033398-3 2005 When CD4+CD25+ cells were depleted, nickel-specific responsiveness was strongly increased both in allergic and in non-allergic individuals, with the most pronounced effect in allergic patients. Nickel 36-42 CD4 molecule Homo sapiens 5-8 16033398-4 2005 These regulatory T cells were anergic to nickel but inhibited nickel-specific CD4+CD25- effector T cells in coculture experiments. Nickel 62-68 CD4 molecule Homo sapiens 78-81 16033398-5 2005 CD4+CD25+ cells from nickel-allergic patients showed only a limited capacity to suppress effector T-cell responsiveness, because an increased nickel reactivity could still be detected in these cocultures. Nickel 21-27 CD4 molecule Homo sapiens 0-3 16033398-5 2005 CD4+CD25+ cells from nickel-allergic patients showed only a limited capacity to suppress effector T-cell responsiveness, because an increased nickel reactivity could still be detected in these cocultures. Nickel 142-148 CD4 molecule Homo sapiens 0-3 16033398-7 2005 Overall, these results support the view that CD4+CD25+ cells can control the activation of nickel-specific effector T cells in non-allergic individuals, whereas this regulatory capacity is impaired in allergic patients. Nickel 91-97 CD4 molecule Homo sapiens 45-48 16188094-0 2005 [Identification of protein peroxiredoxin 2 related to crystalline NiS-induced neoplastic transformation]. Nickel 66-69 peroxiredoxin 2 Homo sapiens 27-42 16095143-11 2005 For persons with atopy markers, odds ratios for contact hypersensitivity ranged from 1.0 to 3.2, the highest being for nickel hypersensitivity among those with total IgE levels greater than 120 kU/L. Nickel 119-125 immunoglobulin heavy constant epsilon Homo sapiens 166-169 15817668-4 2005 Selective stimulation of retinoic acid receptor (RAR) beta/gamma produced marked NIS induction; and selective stimulation of RARalpha, RARgamma, or retinoid X receptor produced more modest induction. Nickel 81-84 retinoic acid receptor alpha Homo sapiens 49-52 15817668-5 2005 Maximal NIS induction was seen with 9-cis retinoic acid and AGN190168, a RAR beta/gamma-agonist. Nickel 8-11 retinoic acid receptor beta Homo sapiens 73-81 15995183-0 2005 Escherichia coli HypA is a zinc metalloprotein with a weak affinity for nickel. Nickel 72-78 hypA Escherichia coli 17-21 15995183-2 2005 HypA or a homologous protein is required for nickel insertion into the hydrogenase precursor proteins. Nickel 45-51 hypA Escherichia coli 0-4 15995183-8 2005 Fluorescence titration experiments demonstrate that HypA binds nickel with micromolar affinity and that the presence of zinc does not dramatically affect the nickel-binding activity. Nickel 63-69 hypA Escherichia coli 52-56 15995183-9 2005 Finally, complex formation between HypA and HypB, another accessory protein required for nickel insertion, was observed. Nickel 89-95 hypA Escherichia coli 35-39 15995183-10 2005 These experiments suggest that HypA is an architectural component of the hydrogenase metallocenter assembly pathway and that it may also have a direct role in the delivery of nickel to the hydrogenase large subunit. Nickel 175-181 hypA Escherichia coli 31-35 15967013-10 2005 This patient with pre-existing nickel allergy developed an allergic contact dermatitis from the injection of a permanent lip liner contaminated with nickel. Nickel 31-37 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 121-124 15967013-10 2005 This patient with pre-existing nickel allergy developed an allergic contact dermatitis from the injection of a permanent lip liner contaminated with nickel. Nickel 149-155 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 121-124 15925313-9 2005 Immobilized nickel affinity chromatography yielded a partially purified recombinant CFT, which exhibited trypsin-specific activity after activation with bovine enterokinase. Nickel 12-18 transmembrane serine protease 15 Bos taurus 160-172 16034673-0 2005 Backbone 1H, 13C, and 15N assignments of a 56 kDa E. coli nickel binding protein NikA. Nickel 58-64 relaxosome component Escherichia coli 81-85 15990730-2 2005 The copper(II) complex formed at physiological pH has a square planar configuration and GnRH complexes with nickel(II) and cobalt(II) ions are less stable than that of copper(II). Nickel 108-114 gonadotropin releasing hormone 1 Homo sapiens 88-92 15866719-8 2005 Greater than 90% of recombinant thioredoxin/NT-proCNP was expressed in the soluble form and purified to near homogeneity in a single chromatographic step using nickel as the metal ion in IMAC. Nickel 160-166 thioredoxin 1 Mus musculus 32-43 15898258-6 2005 "We fought against there being any cuts, but we think these are somewhat palatable," says the American Hospital Association"s Tom Nickels, left. Nickel 130-137 pre-mRNA processing factor 6 Homo sapiens 126-129 15767023-2 2005 Development of undesired reaction to nickel has been positively correlated with the expansion of specific CD8+ T cells, that induce apoptosis of nickel-loaded keratinocytes through a perforin-dependent mechanism. Nickel 37-43 CD8a molecule Homo sapiens 106-109 16054081-5 2005 Both GON-2 and GTL-1 are necessary for intestinal uptake of nickel, but GTL-1 is continuously active while GON-2 is inactivated at higher Mg(2+) levels. Nickel 60-66 Transient receptor potential channel Caenorhabditis elegans 5-10 16054081-5 2005 Both GON-2 and GTL-1 are necessary for intestinal uptake of nickel, but GTL-1 is continuously active while GON-2 is inactivated at higher Mg(2+) levels. Nickel 60-66 LSDAT_euk domain-containing protein Caenorhabditis elegans 15-20 15767023-2 2005 Development of undesired reaction to nickel has been positively correlated with the expansion of specific CD8+ T cells, that induce apoptosis of nickel-loaded keratinocytes through a perforin-dependent mechanism. Nickel 145-151 CD8a molecule Homo sapiens 106-109 15767023-4 2005 Among these, CD4(+)CD25+ T cells from peripheral blood of non allergic subjects strongly regulate immune responses to nickel in a cytokine-independent, cell-contact-dependent mechanism. Nickel 118-124 CD4 molecule Homo sapiens 13-16 15767023-5 2005 In contrast, CD4(+)CD25+ obtained from the blood of nickel-allergic individuals have limited or absent suppressive activity on specific T cell responses in vitro. Nickel 52-58 CD4 molecule Homo sapiens 13-16 15824304-0 2005 Nickel and sulfites food allergy in patients with angioedema associated with ACE Inhibitor use. Nickel 0-6 angiotensin I converting enzyme Homo sapiens 77-80 15904029-0 2005 Spin waves in nickel nanorings of large aspect ratio. Nickel 14-20 spindlin 1 Homo sapiens 0-4 15904029-1 2005 The spin dynamics of high-aspect-ratio nickel nanorings in a longitudinal magnetic field have been investigated by Brillouin spectroscopy and the results are compared with a macroscopic theory and three-dimensional micromagnetic simulations. Nickel 39-45 spindlin 1 Homo sapiens 4-8 15792471-0 2005 Structural, magnetic, and electrical characterization of new polycrystalline phases of nickel- and platinum-doped [(DT-TTF)n][Au(mnt)2] (n = 1, 2). Nickel 87-93 ras homolog family member H Homo sapiens 119-122 16511049-3 2005 Recombinant Trr1 was expressed in Escherichia coli as a His6-tagged fusion protein and purified by nickel-affinity chromatography. Nickel 99-105 thioredoxin-disulfide reductase TRR1 Saccharomyces cerevisiae S288C 12-16 16511065-3 2005 Recombinant Grx2 was expressed in Escherichia coli as a 6xHis-tagged fusion protein and purified by nickel-affinity chromatography. Nickel 100-106 dithiol glutaredoxin GRX2 Saccharomyces cerevisiae S288C 12-16 15900706-8 2005 A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts. Nickel 71-77 synaptophysin Homo sapiens 103-116 15900706-8 2005 A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts. Nickel 71-77 synaptosome associated protein 25 Homo sapiens 131-137 16705796-0 2005 Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line. Nickel 95-101 hypoxia inducible factor 1 subunit alpha inhibitor Homo sapiens 41-46 16705796-0 2005 Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line. Nickel 95-101 N-alpha-acetyltransferase 10, NatA catalytic subunit Homo sapiens 51-56 16705796-1 2005 Although nickel and cobalt compounds have been known to cause induction of the transcription factor hypoxia-inducible factor 1 (HIF-1) and activation of a battery of hypoxia-inducible genes in the cell, the molecular mechanisms of this induction remain unclear. Nickel 9-15 hypoxia inducible factor 1 subunit alpha Homo sapiens 100-126 16705796-1 2005 Although nickel and cobalt compounds have been known to cause induction of the transcription factor hypoxia-inducible factor 1 (HIF-1) and activation of a battery of hypoxia-inducible genes in the cell, the molecular mechanisms of this induction remain unclear. Nickel 9-15 hypoxia inducible factor 1 subunit alpha Homo sapiens 128-133 18969978-2 2005 The method is based on the sorption of Ni(II) ions in a minicolumn containing the synthesized resin, posterior desorption using an acid solution and measurement of the nickel by spectrophotometry (PAR method). Nickel 168-174 jumping translocation breakpoint Homo sapiens 197-200 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 20-23 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 48-72 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 20-23 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 74-83 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 85-88 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 48-72 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 85-88 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 74-83 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 85-88 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 48-72 15750162-3 2005 METHODS: To express NIS gene in cardiomyocytes, alpha-myosin heavy chain (alpha-MHC)-NIS was constructed and used for the production of NIS-transgenic mice. Nickel 85-88 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 74-83 16851238-0 2005 Methanation of CO over nickel: Mechanism and kinetics at high H2/CO ratios. Nickel 23-29 relaxin 2 Homo sapiens 62-67 15843158-5 2005 A combination of Triton X-114 phase separation and nickel-affinity chromatography yielded exclusively prenylated Rab38 that bound [alpha-32P]-GTP. Nickel 51-57 RAB38, member RAS oncogene family Rattus norvegicus 113-118 15510175-11 2005 In conclusion, a therapeutic effect of (131)I has been demonstrated in colon carcinoma cells following induction of tumor-specific iodide uptake activity by CEA promoter-directed NIS expression in vitro. Nickel 179-182 CEA cell adhesion molecule 3 Homo sapiens 157-160 15657188-9 2005 There was a non-significant excess for lung cancer (Obs 28, Exp 20.17, SMR 139, 95% CI 92 to 201), and in subgroup analyses a significantly increased SMR of 231 (Obs 9) was found for those 142 workers with at least five years" employment in the feed handling and nickel extraction departments. Nickel 263-269 LY6/PLAUR domain containing 4 Homo sapiens 150-153 15588916-0 2005 Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha. Nickel 87-93 mitogen-activated protein kinase 1 Homo sapiens 19-23 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 CD34 molecule Homo sapiens 40-44 15801177-1 2005 Azorhodanine derivatives (HL1-HL5) were tested as corrosion inhibitors for nickel in 2M HNO3 solution using weight loss and galvanostatic polarization techniques. Nickel 75-81 intelectin 1 Homo sapiens 26-29 16022661-4 2005 The PDF enzyme is a ferrous ion-containing metallohydrolase, but a nickel-containing surrogate is routinely used in the laboratory for testing inhibitors due to its better stability. Nickel 67-73 peptide deformylase, mitochondrial Homo sapiens 4-7 15736156-7 2005 In kidney of nickel-treated animals, HSP73 and the 96 kDa proteins were overexpressed whereas HSP72 was strongly down regulated. Nickel 13-19 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 94-99 15736156-9 2005 Similarly, in nickel-treated cell lines, HSP72 was downregulated and GRP94 (96 kDa protein) was overexpressed. Nickel 14-20 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 41-46 15736156-9 2005 Similarly, in nickel-treated cell lines, HSP72 was downregulated and GRP94 (96 kDa protein) was overexpressed. Nickel 14-20 heat shock protein 90 beta family member 1 Rattus norvegicus 69-74 15715515-1 2005 OBJECTIVE: Nickel and cobalt ions activate ICAM1 expression on endothelial cells and keratinocytes. Nickel 11-17 intercellular adhesion molecule 1 Homo sapiens 43-48 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 mitogen-activated protein kinase 1 Homo sapiens 74-78 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 CD83 molecule Homo sapiens 118-122 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 CD86 molecule Homo sapiens 124-128 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 C-C motif chemokine receptor 7 Homo sapiens 133-137 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 cadherin 1 Homo sapiens 200-210 15588916-3 2005 In this study, we demonstrated on human CD34(+)-derived DC that the three MAPK are participating to the expression of CD83, CD86 and CCR7 induced by nickel (NiSO(4)) but not to the down-regulation of E-cadherin and Langerin. Nickel 149-155 CD207 molecule Homo sapiens 215-223 20021064-6 2005 However, nickel treatment to normal rats caused a significant increase in the activity of enzymes catalase and GST and in the levels of LPO, whereas the levels of GSH get significantly depressed. Nickel 9-15 catalase Rattus norvegicus 98-106 20021064-6 2005 However, nickel treatment to normal rats caused a significant increase in the activity of enzymes catalase and GST and in the levels of LPO, whereas the levels of GSH get significantly depressed. Nickel 9-15 hematopoietic prostaglandin D synthase Rattus norvegicus 111-114 15549762-2 2004 The corresponding nickel complexes [Ni((4)L(O))(2)] (8) and its cobaltocene reduced form [Co(III)(Cp)(2)][Ni((4)L(O))(2)] (9) have also been synthesized. Nickel 18-24 mitochondrially encoded cytochrome c oxidase III Homo sapiens 90-97 15584756-2 2004 Recombinant cytochrome c oxidase solubilized in detergent was immobilized on a chemically modified gold surface via the affinity of its histidine-tag to a nickel-chelating nitrilo-triacetic acid (NTA) surface. Nickel 155-161 cytochrome c, somatic Homo sapiens 12-24 15522214-4 2004 Iodide efflux is slower in ARH-77 and K-562 cells expressing NIS compared to a thyroid cell line. Nickel 61-64 low density lipoprotein receptor adaptor protein 1 Homo sapiens 27-30 15306540-2 2004 These channels are blocked by nickel, inactivate in 1-2 min in calcium-deprived medium, and are remarkably stimulated by NH(4)Cl, suggesting a role for intracellular pH (pH(i)). Nickel 30-36 glucose-6-phosphate isomerase Homo sapiens 170-175 15306540-10 2004 Likewise, depolarization-induced calcium influx in pH(i)-stimulated and nonstimulated cells was equally blocked by nickel. Nickel 115-121 glucose-6-phosphate isomerase Homo sapiens 51-56 15663561-6 2004 METHODS: Peripheral blood mononuclear cells of nickel allergic patients were cultured in the presence of allergen and increasing concentrations of AID. Nickel 47-53 activation induced cytidine deaminase Homo sapiens 147-150 15302866-2 2004 It has been shown that RET/PTC1 decreases expression of the sodium/iodide symporter (NIS), the molecule that mediates radioiodide therapy for thyroid cancer. Nickel 85-88 ret proto-oncogene Homo sapiens 23-26 15715515-12 2005 Supplemental experiments using nickel ions alone confirmed that ICAM1 was inducible on the endothelial cells by Ni(II) concentrations above 100 microM. Nickel 31-37 intercellular adhesion molecule 1 Homo sapiens 64-69 15579773-1 2004 RET/PTC1, a thyroid-specific oncogene, has been reported to down-regulate sodium/iodide symporter (NIS) expression and function in vitro and in vivo. Nickel 99-102 ret proto-oncogene Rattus norvegicus 0-3 15579773-3 2004 The objective of this study was to investigate whether RET/PTC1-mediated NIS reduction can be rescued by activating cAMP-protein kinase A (PKA) pathways. Nickel 73-76 ret proto-oncogene Rattus norvegicus 55-58 15579773-6 2004 Furthermore, transient expression of catalytic PKA in the nucleus increased radioiodide uptake and NIS protein in RET/PTC1-expressing cells. Nickel 99-102 ret proto-oncogene Rattus norvegicus 114-117 15579773-7 2004 Taken together, these studies suggest that RET/PTC1 down-regulates NIS expression by interrupting TSH/cAMP signaling, and this RET/PTC1 effect can be reversed by activating cAMP-PKA pathways. Nickel 67-70 ret proto-oncogene Rattus norvegicus 43-46 15579773-7 2004 Taken together, these studies suggest that RET/PTC1 down-regulates NIS expression by interrupting TSH/cAMP signaling, and this RET/PTC1 effect can be reversed by activating cAMP-PKA pathways. Nickel 67-70 ret proto-oncogene Rattus norvegicus 127-130 15535990-5 2004 Nickel treatment to the normal control animals, resulted in a significant increase in lipid peroxidation and enzyme activities of catalase and glutathione-S-transferase. Nickel 0-6 catalase Rattus norvegicus 130-138 15535990-5 2004 Nickel treatment to the normal control animals, resulted in a significant increase in lipid peroxidation and enzyme activities of catalase and glutathione-S-transferase. Nickel 0-6 hematopoietic prostaglandin D synthase Rattus norvegicus 143-168 15535990-8 2004 Interestingly, when Zn was supplemented to nickel treated rats, the activities of catalase, and glutathione-S-transferase and the levels of GSH and lipid peroxidation came back to within normal limits. Nickel 43-49 catalase Rattus norvegicus 82-90 15535990-8 2004 Interestingly, when Zn was supplemented to nickel treated rats, the activities of catalase, and glutathione-S-transferase and the levels of GSH and lipid peroxidation came back to within normal limits. Nickel 43-49 hematopoietic prostaglandin D synthase Rattus norvegicus 96-121 15540943-4 2004 (2003) Mechanism of nickel assault on the zinc finger of DNA repair protein XPA. Nickel 20-26 XPA, DNA damage recognition and repair factor Homo sapiens 76-79 15505035-0 2004 Identification of target genes regulated by FOXC1 using nickel agarose-based chromatin enrichment. Nickel 56-62 forkhead box C1 Homo sapiens 44-49 15505035-4 2004 FOXC1-enriched chromatin complexes were isolated by using the tight electrostatic interaction between histidine residues of the recombinant FOXC1 protein and nickel. Nickel 158-164 forkhead box C1 Homo sapiens 0-5 15505035-4 2004 FOXC1-enriched chromatin complexes were isolated by using the tight electrostatic interaction between histidine residues of the recombinant FOXC1 protein and nickel. Nickel 158-164 forkhead box C1 Homo sapiens 140-145 15485485-4 2004 However, compared with the wild-type hNET, the three isoforms (hNET-Ex15L, hNET-Ex14-4 and hNET-Ex14-0) showed a pronounced decrease in V(max) of [(3)H]NE uptake and B(max) of [(3)H]NIS binding which correlated with strongly reduced surface expression of the transporter isoforms. Nickel 182-185 solute carrier family 6 member 2 Homo sapiens 63-67 15485485-4 2004 However, compared with the wild-type hNET, the three isoforms (hNET-Ex15L, hNET-Ex14-4 and hNET-Ex14-0) showed a pronounced decrease in V(max) of [(3)H]NE uptake and B(max) of [(3)H]NIS binding which correlated with strongly reduced surface expression of the transporter isoforms. Nickel 182-185 solute carrier family 6 member 2 Homo sapiens 63-67 15485485-4 2004 However, compared with the wild-type hNET, the three isoforms (hNET-Ex15L, hNET-Ex14-4 and hNET-Ex14-0) showed a pronounced decrease in V(max) of [(3)H]NE uptake and B(max) of [(3)H]NIS binding which correlated with strongly reduced surface expression of the transporter isoforms. Nickel 182-185 solute carrier family 6 member 2 Homo sapiens 63-67 15302866-2 2004 It has been shown that RET/PTC1 decreases expression of the sodium/iodide symporter (NIS), the molecule that mediates radioiodide therapy for thyroid cancer. Nickel 85-88 patched 1 Homo sapiens 27-31 15388354-1 2004 Solid complexes of D-galacturonic acid (GalA) with cobalt(II), copper(II), nickel(II) and oxovanadium(IV) (1-4) were prepared and characterised. Nickel 75-81 galactosidase alpha Homo sapiens 40-44 15360262-0 2004 An unsymmetrical tripodal ligand with NOS2-donor set: coordination chemistry with nickel(II) and zinc(II). Nickel 82-88 nitric oxide synthase 2 Homo sapiens 38-42 15368366-10 2004 We expressed these human Gsalpha (hGsalpha) mutants in bacteria as histidine tagged proteins, purified them by niquel-agarose chromatography and studied their nucleotide exchange properties. Nickel 111-117 GNAS complex locus Homo sapiens 25-32 15368366-10 2004 We expressed these human Gsalpha (hGsalpha) mutants in bacteria as histidine tagged proteins, purified them by niquel-agarose chromatography and studied their nucleotide exchange properties. Nickel 111-117 GNAS complex locus Homo sapiens 34-42 15340050-7 2004 A cotransfected dominant-negative Nkx-2.5 mutant abolished tRA-induced endogenous NIS induction, which shows that Nkx-2.5 activity is critical for this process. Nickel 82-85 NK2 homeobox 5 Homo sapiens 34-41 15229366-0 2004 Microbial stimulation by Mycoplasma fermentans synergistically amplifies IL-6 release by human lung fibroblasts in response to residual oil fly ash (ROFA) and nickel. Nickel 159-165 interleukin 6 Homo sapiens 73-77 15329410-2 2004 All known eukaryotic enzymes contain zinc as their metal cofactor, whereas the Escherichia coli glyoxalase I contains nickel. Nickel 118-124 glyoxalase I Homo sapiens 96-108 15329410-4 2004 Characterization of recombinant L. major glyoxalase I showed it to be unique among the eukaryotic enzymes in sharing the dependence of the E. coli enzyme on nickel. Nickel 157-163 glyoxalase I Homo sapiens 41-53 15226302-2 2004 The wbpA gene that encodes this enzyme was cloned into pET-28a, overexpressed as a histidine-tagged fusion protein, and purified by nickel chelation chromatography. Nickel 132-138 UDP-N-acetyl-d-glucosamine 6-dehydrogenase Pseudomonas aeruginosa PAO1 4-8 15341671-1 2004 BACKGROUND: The expression of NDRG1 gene is induced by nickel, a transition metal sharing similar physical properties to cobalt. Nickel 55-61 N-myc downstream regulated 1 Homo sapiens 30-35 15341671-10 2004 CONCLUSIONS: Hypoxia is an inducer of the NDRG1 gene, and nickel probably causes the induction of the gene by interacting with the oxygen sensory pathway. Nickel 58-64 N-myc downstream regulated 1 Homo sapiens 42-47 15347381-11 2004 As to the production of putatively immunoregulatory cytokines, IL-10 was most informative, with highest production rates in nickel-skin test negative individuals with long-lasting mucosal metal contact preceding skin piercing. Nickel 124-130 interleukin 10 Homo sapiens 63-68 15347381-12 2004 CONCLUSIONS: These results indicate that measuring both T cell proliferation and cytokine secretion profiles, in particular IL-5 release using IL-4/IL-7 supplemented medium, offers a promising improvement of the in vitro diagnostic options in monitoring nickel contact sensitization. Nickel 254-260 interleukin 5 Homo sapiens 124-128 15347381-12 2004 CONCLUSIONS: These results indicate that measuring both T cell proliferation and cytokine secretion profiles, in particular IL-5 release using IL-4/IL-7 supplemented medium, offers a promising improvement of the in vitro diagnostic options in monitoring nickel contact sensitization. Nickel 254-260 interleukin 4 Homo sapiens 143-147 15347381-13 2004 Since oral nickel contact has been shown earlier to induce active tolerization, nickel-induced in vitro IL-10 production may help identify nickel-tolerized individuals. Nickel 80-86 interleukin 10 Homo sapiens 104-109 15347381-13 2004 Since oral nickel contact has been shown earlier to induce active tolerization, nickel-induced in vitro IL-10 production may help identify nickel-tolerized individuals. Nickel 80-86 interleukin 10 Homo sapiens 104-109 15304089-0 2004 Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. Nickel 0-6 C-C motif chemokine receptor 7 Homo sapiens 23-27 15304089-0 2004 Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. Nickel 0-6 tumor necrosis factor Homo sapiens 111-120 15304089-3 2004 We investigated the effects of two well-known haptens, dinitrochlorobenzene (DNCB) and nickel (NiSO(4)), on the expression of CCR7 on human DC derived from CD34(+) progenitor cells. Nickel 87-93 C-C motif chemokine receptor 7 Homo sapiens 126-130 15304089-3 2004 We investigated the effects of two well-known haptens, dinitrochlorobenzene (DNCB) and nickel (NiSO(4)), on the expression of CCR7 on human DC derived from CD34(+) progenitor cells. Nickel 87-93 CD34 molecule Homo sapiens 156-160 15304089-10 2004 Inhibition of both p38 MAPK and JNK affected significantly CCR7 expression upon nickel treatment whereas only inhibition of p38 MAPK but not of JNK downregulated CCR7 in the case of TNF-alpha stimulation. Nickel 80-86 mitogen-activated protein kinase 14 Homo sapiens 19-22 15304089-10 2004 Inhibition of both p38 MAPK and JNK affected significantly CCR7 expression upon nickel treatment whereas only inhibition of p38 MAPK but not of JNK downregulated CCR7 in the case of TNF-alpha stimulation. Nickel 80-86 mitogen-activated protein kinase 8 Homo sapiens 32-35 15304089-10 2004 Inhibition of both p38 MAPK and JNK affected significantly CCR7 expression upon nickel treatment whereas only inhibition of p38 MAPK but not of JNK downregulated CCR7 in the case of TNF-alpha stimulation. Nickel 80-86 C-C motif chemokine receptor 7 Homo sapiens 59-63 15347726-2 2004 By targeting NIS expression in SK-Hep1, we could also investigate whether these cells concentrate 99mTc-pertechnetate and 188Re-perrhenate as well as 125I in vitro and in vivo. Nickel 13-16 DNL-type zinc finger Homo sapiens 34-38 15347726-10 2004 NIS gene transfection into SK-Hep1 also resulted in 112- and 87-fold increases of 99mTc-pertechnetate and 188Re-perrhenate uptake, respectively. Nickel 0-3 DNL-type zinc finger Homo sapiens 30-34 15347726-12 2004 In the biodistribution study using SK-Hep1-NIS-xenographed mice, the tumor uptake of 125I, 188Re-perrhenate, and 99mTc-pertechnetate was 68.0 +/- 15.0, 46.2 +/- 9.1, and 59.6 +/- 16.2 %ID/g (percentage injected dose per gram) at 2 h after injection, respectively. Nickel 43-46 DNL-type zinc finger Mus musculus 38-42 15347726-15 2004 These results demonstrated that SK-Hep1-NIS could be selectively killed by the induced 131I and 188Re-perrhenate accumulation through NIS gene expression. Nickel 40-43 DNL-type zinc finger Homo sapiens 35-39 15340050-7 2004 A cotransfected dominant-negative Nkx-2.5 mutant abolished tRA-induced endogenous NIS induction, which shows that Nkx-2.5 activity is critical for this process. Nickel 82-85 NK2 homeobox 5 Homo sapiens 114-121 15340050-8 2004 Remarkably, in MCF-7 cells, Nkx-2.5 overexpression alone was sufficient to induce NIS and iodide uptake. Nickel 82-85 NK2 homeobox 5 Homo sapiens 28-35 15294293-9 2004 The p38alpha protein was purified to near homogeneity using a simple two-step procedure including nickel-chelating Sepharose chromatography followed by anion-exchange chromatography using MonoQ resin. Nickel 98-104 mitogen-activated protein kinase 14 Homo sapiens 4-12 15257594-0 2004 The coordination chemistry of "[BP3]NiX" platforms: targeting low-valent nickel sources as promising candidates to L3Ni=E and L3Ni(triple bond)E linkages. Nickel 73-79 BCL2 interacting protein 3 like Homo sapiens 36-39 15240692-0 2004 Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. Nickel 18-24 CD4 antigen Mus musculus 34-37 15240692-1 2004 Previously, oral administration of nickel to C57BL/6 wild-type (WT) mice was shown to render both their splenic T cells and APCs (i.e., T cell-depleted spleen cells) capable of transferring nickel tolerance to naive syngeneic recipients. Nickel 35-41 amyloid P component, serum Mus musculus 124-128 15240692-1 2004 Previously, oral administration of nickel to C57BL/6 wild-type (WT) mice was shown to render both their splenic T cells and APCs (i.e., T cell-depleted spleen cells) capable of transferring nickel tolerance to naive syngeneic recipients. Nickel 190-196 amyloid P component, serum Mus musculus 124-128 15240692-5 2004 Hence, during oral nickel administration, tolerogenic APCs are generated that require iNKT cell help for the induction of Treg cells. Nickel 19-25 amyloid P component, serum Mus musculus 54-58 15240692-9 2004 We conclude that CD4(+) iNKT cells are required for the induction of oral nickel tolerance and, in particular, for the infectious spread of tolerance from APCs to T cells. Nickel 74-80 CD4 antigen Mus musculus 17-20 15225021-1 2004 The reaction of (2-SiH3C6H4)2SiH2 with Ni(Et2PCH2CH2PEt2)(PEt3)2 afforded a new silylnickel complex, which, in the solid state, was determined to be a bis(silyl)eta2-(Si-H)nickel complex, the first example of eta2-(Si-H)nickel complex by single-crystal X-ray analysis. Nickel 85-91 DNA polymerase iota Homo sapiens 161-165 15225021-1 2004 The reaction of (2-SiH3C6H4)2SiH2 with Ni(Et2PCH2CH2PEt2)(PEt3)2 afforded a new silylnickel complex, which, in the solid state, was determined to be a bis(silyl)eta2-(Si-H)nickel complex, the first example of eta2-(Si-H)nickel complex by single-crystal X-ray analysis. Nickel 85-91 DNA polymerase iota Homo sapiens 209-213 15237137-0 2004 Thiocyanates of nickel and caesium: Cs2NiAg2(SCN)6.2H2O and CsNi(SCN)3. Nickel 16-22 HCLS1 associated protein X-1 Homo sapiens 60-70 15257594-1 2004 A series of divalent, monovalent, and zerovalent nickel complexes supported by the electron-releasing, monoanionic tris(phosphino)borate ligands [PhBP3] and [PhBPiPr3] ([PhBP3] = [PhB(CH2PPh2)3]-, [PhBPiPr3] = [PhB(CH2PiPr2)3]-) have been synthesized to explore fundamental aspects of their coordination chemistry. Nickel 49-55 PHB1 pseudogene 3 Homo sapiens 146-151 15270870-8 2004 Analysis of nickel-reactive T cells for expression of distinct chemokine receptors showed that both proliferative capacity and cytokine production are restricted to subsets expressing CXCR3, CCR4 but not CCR6. Nickel 12-18 C-X-C motif chemokine receptor 3 Homo sapiens 184-189 15270870-0 2004 Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Nickel 0-6 CD4 molecule Homo sapiens 30-33 15270870-0 2004 Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Nickel 0-6 selectin P ligand Homo sapiens 35-38 15270870-0 2004 Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Nickel 0-6 C-X-C motif chemokine receptor 3 Homo sapiens 80-85 15270870-0 2004 Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Nickel 0-6 C-C motif chemokine receptor 4 Homo sapiens 87-91 15270870-0 2004 Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Nickel 0-6 C-C motif chemokine receptor 10 Homo sapiens 96-101 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 CD4 molecule Homo sapiens 14-17 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 selectin P ligand Homo sapiens 19-22 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 protein tyrosine phosphatase receptor type C Homo sapiens 24-28 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 interferon gamma Homo sapiens 82-99 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 interleukin 5 Homo sapiens 113-117 15270870-6 2004 Moreover, cells expressing the marker CLA in combination with CD4, CD45RO or CD69 are increased after nickel-specific stimulation. Nickel 102-108 selectin P ligand Homo sapiens 38-41 15270870-6 2004 Moreover, cells expressing the marker CLA in combination with CD4, CD45RO or CD69 are increased after nickel-specific stimulation. Nickel 102-108 CD4 molecule Homo sapiens 62-65 15270870-6 2004 Moreover, cells expressing the marker CLA in combination with CD4, CD45RO or CD69 are increased after nickel-specific stimulation. Nickel 102-108 CD69 molecule Homo sapiens 77-81 15198611-7 2004 Electronic structure calculations using density functional theory (DFT) reveal that the enhanced reaction rate for [L(8)py(2)Ni(SAr)](+) is rooted in a four-electron repulsion (or a "filled/filled interaction") between a completely filled nickel(II) d(pi) orbital and one of the two thiolate frontier orbitals, a condition that is absent in the Fe(II) and Co(II) complexes. Nickel 239-245 mitochondrially encoded cytochrome c oxidase II Homo sapiens 356-362 15177755-0 2004 Tuning the diffusion dialysis performance by surface cross-linking of PPO anion exchange membranes--simultaneous recovery of sulfuric acid and nickel from electrolysis spent liquor of relatively low acid concentration. Nickel 143-149 protoporphyrinogen oxidase Homo sapiens 70-73 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 selectin P ligand Homo sapiens 163-166 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 C-X-C motif chemokine receptor 3 Homo sapiens 171-176 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 C-C motif chemokine receptor 4 Homo sapiens 178-182 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 C-C motif chemokine receptor 10 Homo sapiens 206-211 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 selectin P ligand Homo sapiens 259-262 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 81-87 C-C motif chemokine receptor 6 Homo sapiens 310-314 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 264-270 selectin P ligand Homo sapiens 163-166 15270870-9 2004 Fluorescence-activated cell sorting analysis of chemokine receptors expressed on nickel-stimulated T cells confirmed these results; a subset of T cells expressing CLA and CXCR3, CCR4 and, most importantly, CCR10 increased in response to allergen, while these CLA+ nickel-reactive T cells were all negative for CCR6. Nickel 264-270 C-C motif chemokine receptor 10 Homo sapiens 206-211 15270870-10 2004 CONCLUSIONS: These findings demonstrate that freshly isolated nickel-reactive T cells can be characterized as CD4+ CLA+ memory T cells which express the chemokine receptors CXCR3, CCR4 and CCR10, but not CCR6. Nickel 62-68 CD4 molecule Homo sapiens 110-113 15270870-10 2004 CONCLUSIONS: These findings demonstrate that freshly isolated nickel-reactive T cells can be characterized as CD4+ CLA+ memory T cells which express the chemokine receptors CXCR3, CCR4 and CCR10, but not CCR6. Nickel 62-68 selectin P ligand Homo sapiens 115-118 15270870-10 2004 CONCLUSIONS: These findings demonstrate that freshly isolated nickel-reactive T cells can be characterized as CD4+ CLA+ memory T cells which express the chemokine receptors CXCR3, CCR4 and CCR10, but not CCR6. Nickel 62-68 C-X-C motif chemokine receptor 3 Homo sapiens 173-178 15270870-10 2004 CONCLUSIONS: These findings demonstrate that freshly isolated nickel-reactive T cells can be characterized as CD4+ CLA+ memory T cells which express the chemokine receptors CXCR3, CCR4 and CCR10, but not CCR6. Nickel 62-68 C-C motif chemokine receptor 4 Homo sapiens 180-184 15270870-10 2004 CONCLUSIONS: These findings demonstrate that freshly isolated nickel-reactive T cells can be characterized as CD4+ CLA+ memory T cells which express the chemokine receptors CXCR3, CCR4 and CCR10, but not CCR6. Nickel 62-68 C-C motif chemokine receptor 10 Homo sapiens 189-194 15186240-0 2004 Morphometric analysis of shank-to-flute ratio in rotary nickel-titanium files. Nickel 56-62 SH3 and multiple ankyrin repeat domains 2 Homo sapiens 25-30 15135396-6 2004 Proteins were purified as the p85alpha/p110 complex by nickel affinity chromatography through an N-terminal His-tag on the p110 subunit using an imidazole gradient. Nickel 55-61 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 30-38 15135396-6 2004 Proteins were purified as the p85alpha/p110 complex by nickel affinity chromatography through an N-terminal His-tag on the p110 subunit using an imidazole gradient. Nickel 55-61 endogenous retrovirus group K member 15 Homo sapiens 39-43 15037616-8 2004 We tested in vitro complex formation by wild-type and mutant XRCC3 with His6-tagged Rad51C upon co-expression in bacteria, nickel-affinity purification, and Western blotting. Nickel 123-129 DNA repair protein XRCC3 Cricetulus griseus 61-66 15037616-8 2004 We tested in vitro complex formation by wild-type and mutant XRCC3 with His6-tagged Rad51C upon co-expression in bacteria, nickel-affinity purification, and Western blotting. Nickel 123-129 DNA repair protein RAD51 homolog 3 Cricetulus griseus 84-90 15094311-0 2004 Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Nickel 0-6 glucan (1,4-alpha-), branching enzyme 1 Mus musculus 15-50 15090500-1 2004 HypA and HypB are maturation proteins required for incorporation of nickel into the hydrogenase large subunit. Nickel 68-74 hypA Escherichia coli 0-4 15090500-10 2004 A triple mutant deficient in the synthesis or activity of HypA, HybF, and HypB was constructed, and it exhibited the same responsiveness for phenotypic complementation by high nickel as mutants with a single lesion in one of the genes exhibited. Nickel 176-182 hypA Escherichia coli 58-62 15090500-11 2004 The results are interpreted in terms of a concerted action of HypB and HybF in nickel insertion in which HybF (as well as its homolog, HypA) functions as a metallochaperone and HypB functions as a regulator that controls the interaction of HybF with the target protein. Nickel 79-85 hypA Escherichia coli 135-139 15094311-1 2004 Using the mouse Affymetrix gene chip, we found that 1,4-alpha-glucan branching enzyme 1 (GBE1) was one of the most up-regulated genes following nickel exposure. Nickel 144-150 glucan (1,4-alpha-), branching enzyme 1 Mus musculus 52-87 15094311-1 2004 Using the mouse Affymetrix gene chip, we found that 1,4-alpha-glucan branching enzyme 1 (GBE1) was one of the most up-regulated genes following nickel exposure. Nickel 144-150 glucan (1,4-alpha-), branching enzyme 1 Mus musculus 89-93 15099111-1 2004 Density functional theory indicates that oxidative addition of the C-F and C-H bonds in C6F6 and C6H6 at zerovalent nickel and platinum fragments, M(H2PCH2CH2PH2), proceeds via initial exothermic formation of an eta2-coordinated arene complex. Nickel 116-122 DNA polymerase iota Homo sapiens 212-216 15043985-8 2004 Western blots demonstrated the nickel affinity purified rhHDAC1 preparation also contained endogenous HDAC2 and HDAC3; likewise, rhHDAC3 preparation contained endogenous HDAC1 and HDAC2. Nickel 31-37 histone deacetylase 2 Homo sapiens 102-107 15043985-8 2004 Western blots demonstrated the nickel affinity purified rhHDAC1 preparation also contained endogenous HDAC2 and HDAC3; likewise, rhHDAC3 preparation contained endogenous HDAC1 and HDAC2. Nickel 31-37 histone deacetylase 3 Homo sapiens 112-117 15043985-8 2004 Western blots demonstrated the nickel affinity purified rhHDAC1 preparation also contained endogenous HDAC2 and HDAC3; likewise, rhHDAC3 preparation contained endogenous HDAC1 and HDAC2. Nickel 31-37 histone deacetylase 1 Homo sapiens 58-63 15047186-4 2004 Biochemical characterizations of nickel affinity-purified and size-fractionated Nanodiscs indicate that CYP73A5 protein assembled into Nanodiscs in the absence of NADPH P450 reductase maintains its ability to bind its t-cinnamic acid substrate. Nickel 33-39 cinnamate-4-hydroxylase Arabidopsis thaliana 104-111 15081272-8 2004 The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production. Nickel 71-77 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 15054768-3 2004 Then, CO inserts into the Ni-N bond and the weak apical Ni--S bond rebounds to its original strength as the nickel forms a square-planar intermediate. Nickel 108-114 solute carrier family 5 member 5 Homo sapiens 56-61 14715652-10 2004 In cells expressing NIS and pendrin, pendrin mediates transport of iodide into the apical chamber. Nickel 20-23 solute carrier family 26 member 4 Canis lupus familiaris 37-44 14729311-3 2004 Biological studies, carried out in vitro on human leukemic cell lines TOM 1 and NB4, have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation. Nickel 134-140 target of myb1 membrane trafficking protein Homo sapiens 70-75 15039075-6 2004 Transcriptionally active forms of both wild type and point mutants of Rpo41 can be purified by a combination of batch ion exchange chromatography to remove nucleic acids and nickel affinity chromatography. Nickel 174-180 DNA-directed RNA polymerase Saccharomyces cerevisiae S288C 70-75 15252479-3 2004 Solid structures of 9, 11, 13 and the intermediate eta1-benzyl nickel(II) complexes, [Ph2PC6H4C(O)NR-kappa2N,P]Ni(eta1-CH2C6H5)(PMe3) (R = C6H5, 7; R = C(CH3)3, 8) were determined by X-ray crystallography. Nickel 63-69 secreted phosphoprotein 1 Homo sapiens 51-55 15020194-7 2004 Nickel contact induced upregulation of MMP-2 and IL-8 mRNA production. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 39-44 15020194-7 2004 Nickel contact induced upregulation of MMP-2 and IL-8 mRNA production. Nickel 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 49-53 14699112-6 2004 We further investigated substrate specificity and observed that ZmYS1 complemented the growth defect of the zinc uptake-defective yeast mutant zap1 and transported various phytosiderophore-bound metals into oocytes, including zinc, copper, nickel, and, at a lower rate, also manganese and cadmium. Nickel 240-246 iron-phytosiderophore transporter yellow stripe 1 Zea mays 64-69 15030331-8 2004 RESULTS: Nickel-stimulated PBMC of nickel-allergic patients with AD proliferated significantly less and secreted significantly lower amounts of IL-2 than cells of nonatopic nickel-allergic patients. Nickel 9-15 interleukin 2 Homo sapiens 144-148 15030331-8 2004 RESULTS: Nickel-stimulated PBMC of nickel-allergic patients with AD proliferated significantly less and secreted significantly lower amounts of IL-2 than cells of nonatopic nickel-allergic patients. Nickel 35-41 interleukin 2 Homo sapiens 144-148 15030331-12 2004 Nickel-induced IL-2 production correlated well with IL-5 production in nickel-allergic patients regardless of their atopic status. Nickel 0-6 interleukin 2 Homo sapiens 15-19 15030331-12 2004 Nickel-induced IL-2 production correlated well with IL-5 production in nickel-allergic patients regardless of their atopic status. Nickel 0-6 interleukin 5 Homo sapiens 52-56 14630715-6 2004 When the expression plasmid of APE/Ref-1 was transfected together with an expression plasmid for PAX8, a strong cooperative effect was detected with an increase of NIS promoter activity 9-fold over control. Nickel 164-167 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 31-34 14630715-6 2004 When the expression plasmid of APE/Ref-1 was transfected together with an expression plasmid for PAX8, a strong cooperative effect was detected with an increase of NIS promoter activity 9-fold over control. Nickel 164-167 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 35-40 14630715-6 2004 When the expression plasmid of APE/Ref-1 was transfected together with an expression plasmid for PAX8, a strong cooperative effect was detected with an increase of NIS promoter activity 9-fold over control. Nickel 164-167 paired box 8 Homo sapiens 97-101 14999802-0 2004 Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS). Nickel 110-113 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 85-108 14999802-1 2004 BACKGROUND: Gene therapy that uses delivery of the sodium-iodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers. Nickel 76-79 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 51-74 14735332-0 2004 Modeling carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS): a trinuclear nickel complex employing deprotonated amides and bridging thiolates. Nickel 84-90 acyl-CoA synthetase short chain family member 2 Homo sapiens 60-69 14586031-6 2004 Second, PRL also activated an inwardly directed current, mainly due to the stimulation of calcium influx via nickel- and 2-APB-sensitive calcium channels. Nickel 109-115 prolactin Homo sapiens 8-11 14734778-0 2004 Metal-protein complex-mediated transport and delivery of Ni2+ to TCR/MHC contact sites in nickel-specific human T cell activation. Nickel 90-96 major histocompatibility complex, class I, C Homo sapiens 69-72 12960164-0 2003 Crystal structures of the liganded and unliganded nickel-binding protein NikA from Escherichia coli. Nickel 50-56 relaxosome component Escherichia coli 73-77 14726713-6 2004 Iron is central to the oxygen sensing mechanism, and sensitivity to other metals, namely cobalt and nickel, is a distinctive feature of the HIF system; in fact, this is often used as an initial way of implicating HIF-1 in a biological response. Nickel 100-106 hypoxia inducible factor 1 subunit alpha Homo sapiens 213-218 14729612-0 2004 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Nickel 0-6 thymoma viral proto-oncogene 1 Mus musculus 59-62 14729612-0 2004 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Nickel 0-6 E74 like ETS transcription factor 1 Mus musculus 74-77 14729612-0 2004 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Nickel 0-6 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 78-81 14729612-0 2004 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Nickel 0-6 N-myc downstream regulated gene 1 Mus musculus 158-163 14729612-5 2004 Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation. Nickel 116-122 thymoma viral proto-oncogene 1 Mus musculus 21-24 14729612-5 2004 Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation. Nickel 116-122 E74 like ETS transcription factor 1 Mus musculus 30-33 14729612-5 2004 Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation. Nickel 116-122 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 34-37 14729612-5 2004 Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation. Nickel 116-122 hypoxia inducible factor 1 subunit alpha Homo sapiens 131-136 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 thymoma viral proto-oncogene 1 Mus musculus 56-59 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 thymoma viral proto-oncogene 1 Mus musculus 68-71 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 thymoma viral proto-oncogene 1 Mus musculus 68-71 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 hypoxia inducible factor 1 subunit alpha Homo sapiens 132-137 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 E74 like ETS transcription factor 1 Mus musculus 177-180 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 181-184 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 93-99 hypoxia inducible factor 1 subunit alpha Homo sapiens 284-289 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 317-323 thymoma viral proto-oncogene 1 Mus musculus 56-59 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 317-323 thymoma viral proto-oncogene 1 Mus musculus 68-71 14729612-6 2004 Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds. Nickel 317-323 thymoma viral proto-oncogene 1 Mus musculus 68-71 14729612-7 2004 Consistent with HIF-1 transactivation, inhibition of the PI-3K/Akt pathway by either overexpression of Deltap85 or Akt-T308A/S473A caused dramatic inhibition of Cap43 protein expression induced by nickel compounds, whereas pretreatment of cells with rapamycin did not exhibit inhibition of Cap43 induction. Nickel 197-203 thymoma viral proto-oncogene 1 Mus musculus 115-118 14729612-7 2004 Consistent with HIF-1 transactivation, inhibition of the PI-3K/Akt pathway by either overexpression of Deltap85 or Akt-T308A/S473A caused dramatic inhibition of Cap43 protein expression induced by nickel compounds, whereas pretreatment of cells with rapamycin did not exhibit inhibition of Cap43 induction. Nickel 197-203 N-myc downstream regulated gene 1 Mus musculus 161-166 14729612-8 2004 These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway. Nickel 32-38 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-61 14729612-8 2004 These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway. Nickel 32-38 N-myc downstream regulated gene 1 Mus musculus 82-87 14729612-8 2004 These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway. Nickel 32-38 thymoma viral proto-oncogene 1 Mus musculus 123-126 14729612-8 2004 These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway. Nickel 32-38 E74 like ETS transcription factor 1 Mus musculus 141-144 14729612-8 2004 These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway. Nickel 32-38 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 145-148 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 0-6 selectin P ligand Homo sapiens 144-147 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 0-6 CD8a molecule Homo sapiens 153-156 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 0-6 selectin P ligand Homo sapiens 166-169 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 0-6 CD8a molecule Homo sapiens 214-217 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 0-6 selectin P ligand Homo sapiens 166-169 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 79-85 selectin P ligand Homo sapiens 144-147 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 79-85 CD8a molecule Homo sapiens 153-156 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 79-85 selectin P ligand Homo sapiens 166-169 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 79-85 CD8a molecule Homo sapiens 214-217 15059101-6 2004 Nickel-sensitive individuals whose dermatitis flared after oral challenge with nickel showed significant decreases in fractions of CD3+ CD45RO+ CLA+ and CD8+ CD45RO+ CLA+ blood lymphocytes, suggesting migration of CD8+ "memory" CLA+ T lymphocytes from the blood to peripheral tissues. Nickel 79-85 selectin P ligand Homo sapiens 166-169 15059101-7 2004 Only those nickel-sensitive individuals who clinically reacted to oral challenge with nickel (4 mg) had elevated levels of IL-5 in the serum, indicating an activation of type 2 T lymphocytes in the peripheral blood. Nickel 11-17 interleukin 5 Homo sapiens 123-127 15059101-7 2004 Only those nickel-sensitive individuals who clinically reacted to oral challenge with nickel (4 mg) had elevated levels of IL-5 in the serum, indicating an activation of type 2 T lymphocytes in the peripheral blood. Nickel 86-92 interleukin 5 Homo sapiens 123-127 15059101-8 2004 In conclusion, the study indicates that CD8+ CD45RO+ CLA+ T lymphocytes and T lymphocytes with a type 2 cytokine profile are involved in SCD elicited by nickel. Nickel 153-159 CD8a molecule Homo sapiens 40-43 15059101-8 2004 In conclusion, the study indicates that CD8+ CD45RO+ CLA+ T lymphocytes and T lymphocytes with a type 2 cytokine profile are involved in SCD elicited by nickel. Nickel 153-159 selectin P ligand Homo sapiens 53-56 15881401-2 2004 By tuning up the conditions for the expression of nKHC, a sufficient amount of the soluble protein intragenously tagged with 6xHis tag was obtained and purified by nickel chromatography. Nickel 164-170 kinesin family member 5C Homo sapiens 50-54 14971660-0 2004 Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Nickel 35-41 fragile histidine triad gene Mus musculus 8-12 14971660-0 2004 Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Nickel 73-79 fragile histidine triad gene Mus musculus 8-12 14971660-4 2004 Previously, we have shown that the phosphohydrolase activity of Fhit protein, associated with its tumor suppressor action, is inhibited by nickel. Nickel 139-145 fragile histidine triad gene Mus musculus 64-68 14971660-6 2004 The latter could be further enhanced if nickel also lowered cellular levels of Fhit protein itself, e.g. by down-regulation of FHIT gene. Nickel 40-46 fragile histidine triad gene Mus musculus 79-83 14971660-6 2004 The latter could be further enhanced if nickel also lowered cellular levels of Fhit protein itself, e.g. by down-regulation of FHIT gene. Nickel 40-46 fragile histidine triad gene Mus musculus 127-131 14971660-15 2004 Overall, the decline of Fhit in cells or tissues malignantly transformed by nickel may indicate possible involvement of this effect in the mechanisms of nickel carcinogenesis. Nickel 76-82 fragile histidine triad gene Mus musculus 24-28 14971660-15 2004 Overall, the decline of Fhit in cells or tissues malignantly transformed by nickel may indicate possible involvement of this effect in the mechanisms of nickel carcinogenesis. Nickel 153-159 fragile histidine triad gene Mus musculus 24-28 14671024-5 2004 Nickel affinity chromatography purification of ZmPIP2;1 fused to a His tag coeluted with ZmPIP1;2-GFP demonstrated physical interaction and heteromerization of both isoforms. Nickel 0-6 aquaporin PIP2-1 Zea mays 47-55 14671024-5 2004 Nickel affinity chromatography purification of ZmPIP2;1 fused to a His tag coeluted with ZmPIP1;2-GFP demonstrated physical interaction and heteromerization of both isoforms. Nickel 0-6 aquaporin PIP1-2 Zea mays 89-97 12960164-2 2003 Nickel homeostasis systems include the dedicated nickel uptake system nik found in Escherichia coli, a member of the ABC family of transporters, that involves a periplasmic nickel-binding protein, NikA. Nickel 0-6 relaxosome component Escherichia coli 197-201 12960164-2 2003 Nickel homeostasis systems include the dedicated nickel uptake system nik found in Escherichia coli, a member of the ABC family of transporters, that involves a periplasmic nickel-binding protein, NikA. Nickel 49-55 relaxosome component Escherichia coli 197-201 12960164-2 2003 Nickel homeostasis systems include the dedicated nickel uptake system nik found in Escherichia coli, a member of the ABC family of transporters, that involves a periplasmic nickel-binding protein, NikA. Nickel 173-179 relaxosome component Escherichia coli 197-201 12960164-4 2003 We have solved the crystal structure of NikA protein in the presence and absence of nickel, showing that it behaves as a "classical" periplasmic binding protein. Nickel 84-90 relaxosome component Escherichia coli 40-44 12960164-8 2003 Despite relatively weak binding, NikA is specific for nickel. Nickel 54-60 relaxosome component Escherichia coli 33-37 14639089-1 2003 Although nifedipine and other conventional calcium antagonists elicit preferential vasodilation of renal afferent arterioles, we demonstrate that mibefradil and nickel, T-type calcium channel blockers, reverse the angiotensin II-induced constriction of both afferent and efferent arterioles. Nickel 161-167 angiotensinogen Rattus norvegicus 214-228 14634084-0 2003 Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. Nickel 60-66 interleukin 2 receptor subunit alpha Homo sapiens 6-10 14634084-1 2003 We investigated the capacity of CD25(+) T regulatory cells (Treg) to modulate T cell responses to nickel, a common cause of allergic contact dermatitis. Nickel 98-104 interleukin 2 receptor subunit alpha Homo sapiens 32-36 14634084-2 2003 CD4(+) T cells isolated from the peripheral blood of six healthy, nonallergic individuals showed a limited capacity to proliferate in response to nickel in vitro, but responsiveness was strongly augmented (mean increment +/- SD, 240 +/- 60%) when cells were depleted of CD25(+) Treg. Nickel 146-152 CD4 molecule Homo sapiens 0-3 14634084-3 2003 Although CD25(+) Treg were anergic to nickel, a small percentage up-regulated membrane CTLA-4 upon nickel exposure. Nickel 38-44 interleukin 2 receptor subunit alpha Homo sapiens 9-13 14634084-3 2003 Although CD25(+) Treg were anergic to nickel, a small percentage up-regulated membrane CTLA-4 upon nickel exposure. Nickel 99-105 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 87-93 14634084-4 2003 CD25(+) Treg strongly and dose-dependently inhibited nickel-specific activation of CD25(-) T lymphocytes in coculture experiments in a cytokine-independent, but cell-to-cell contact-dependent, manner. Nickel 53-59 interleukin 2 receptor subunit alpha Homo sapiens 0-4 14634084-4 2003 CD25(+) Treg strongly and dose-dependently inhibited nickel-specific activation of CD25(-) T lymphocytes in coculture experiments in a cytokine-independent, but cell-to-cell contact-dependent, manner. Nickel 53-59 interleukin 2 receptor subunit alpha Homo sapiens 83-87 14634084-5 2003 Approximately 30% of circulating CD25(+) Treg expressed the cutaneous lymphocyte-associated Ag (CLA), and CLA(+)CD25(+) Treg were more efficient than CLA(-)CD25(+) cells in suppressing nickel responsiveness of CD25(-) T cells. Nickel 185-191 selectin P ligand Homo sapiens 106-109 14634084-5 2003 Approximately 30% of circulating CD25(+) Treg expressed the cutaneous lymphocyte-associated Ag (CLA), and CLA(+)CD25(+) Treg were more efficient than CLA(-)CD25(+) cells in suppressing nickel responsiveness of CD25(-) T cells. Nickel 185-191 selectin P ligand Homo sapiens 106-109 14634084-6 2003 The site of a negative patch test in response to nickel showed an infiltrate of CD4(+)CLA(+) cells and CD25(+) cells, which accounted for approximately 20% of the total T cells isolated from the tissue. Nickel 49-55 CD4 molecule Homo sapiens 80-83 14634084-6 2003 The site of a negative patch test in response to nickel showed an infiltrate of CD4(+)CLA(+) cells and CD25(+) cells, which accounted for approximately 20% of the total T cells isolated from the tissue. Nickel 49-55 selectin P ligand Homo sapiens 86-89 14634084-6 2003 The site of a negative patch test in response to nickel showed an infiltrate of CD4(+)CLA(+) cells and CD25(+) cells, which accounted for approximately 20% of the total T cells isolated from the tissue. Nickel 49-55 interleukin 2 receptor subunit alpha Homo sapiens 103-107 14634084-7 2003 Skin-derived T cells suppressed nickel-specific responses of peripheral blood CD25(-) T cells. Nickel 32-38 interleukin 2 receptor subunit alpha Homo sapiens 78-82 14634084-8 2003 In addition, 60 +/- 14% of peripheral blood CD25(+) Treg expressed the chemokine receptor CCR7 and strongly inhibited naive T cell activation in response to nickel. Nickel 157-163 interleukin 2 receptor subunit alpha Homo sapiens 44-48 14634084-8 2003 In addition, 60 +/- 14% of peripheral blood CD25(+) Treg expressed the chemokine receptor CCR7 and strongly inhibited naive T cell activation in response to nickel. Nickel 157-163 C-C motif chemokine receptor 7 Homo sapiens 90-94 14634084-9 2003 Finally, CD25(+) T cells isolated from peripheral blood of nickel-allergic patients showed a limited or absent capacity to suppress metal-specific CD4(+) and CD8(+) T cell responses. Nickel 59-65 interleukin 2 receptor subunit alpha Homo sapiens 9-13 14634084-9 2003 Finally, CD25(+) T cells isolated from peripheral blood of nickel-allergic patients showed a limited or absent capacity to suppress metal-specific CD4(+) and CD8(+) T cell responses. Nickel 59-65 CD4 molecule Homo sapiens 147-150 14634084-9 2003 Finally, CD25(+) T cells isolated from peripheral blood of nickel-allergic patients showed a limited or absent capacity to suppress metal-specific CD4(+) and CD8(+) T cell responses. Nickel 59-65 CD8a molecule Homo sapiens 158-161 14634084-10 2003 The results indicates that in healthy individuals CD25(+) Treg can control the activation of both naive and effector nickel-specific T cells. Nickel 117-123 interleukin 2 receptor subunit alpha Homo sapiens 50-54 14645679-0 2003 Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Nickel 105-111 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-32 14520703-9 2003 There was some indication of weaker associations between K-ras mutations and occupational exposure to lead, PAHs, benzo[a]pyrene, gasoline, nickel, inhalatory exposure to chromium and sedentary work. Nickel 140-146 KRAS proto-oncogene, GTPase Homo sapiens 57-62 14606841-4 2003 The ligand is found to exert a strong trans influence on the structure of the complexes in the solid state with the nickel(II) and iron(III) complexes demonstrating a cis and fac geometry, respectively. Nickel 116-122 FA complementation group C Homo sapiens 175-178 14570485-7 2003 2002, 124, 13242) interpreted their resonance Raman data and titration experiments as indicating that, in MCR(red1), coenzyme F430 is not only reduced at the nickel center but at one of the C=N double bonds of the hydrocorphinoid macrocycle as well. Nickel 158-164 adenosine deaminase RNA specific B1 Homo sapiens 110-114 12966575-0 2003 Fabrication of nickel and chromium nanoparticles using the protein cage of apoferritin. Nickel 15-21 ferritin heavy chain Equus caballus 75-86 12966575-4 2003 We incubated apoferritin in nickel or chromium salt solutions to fabricate hydroxide nanoparticles in the cavity. Nickel 28-34 ferritin heavy chain Equus caballus 13-24 12966575-6 2003 During the hydroxylation process of nickel ions a large portion of the apoferritin precipitated through bulk precipitation of nickel hydroxide. Nickel 36-42 ferritin heavy chain Equus caballus 71-82 12966575-10 2003 The optimized condition for nickel core formation was 0.3 mg/mL horse spleen apoferritin and 5 mM ammonium nickel sulfate in water containing dissolved carbon dioxide. Nickel 28-34 ferritin heavy chain Equus caballus 77-88 12966575-15 2003 In nickel and chromium core formation, carbonate ions would play an important role in accelerating the hydroxylation in the apoferritin cavity compared to the bulk solution outside. Nickel 3-9 ferritin heavy chain Equus caballus 124-135 14516743-3 2003 Endonuclease I is active in the presence of magnesium, manganese, iron (II) and cobalt (II) ions, weakly active in the presence of nickel, copper (II) and zinc ions, and completely inactive in the presence of calcium ions. Nickel 131-137 endonuclease I Escherichia phage T7 0-14 14645679-0 2003 Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Nickel 105-111 aryl hydrocarbon receptor Homo sapiens 60-85 14645679-3 2003 Because nickel is known to mimic hypoxia, we investigated the effects of short-term nickel exposure on AhR-dependent gene expression. Nickel 84-90 aryl hydrocarbon receptor Homo sapiens 103-106 14645679-4 2003 Gene-chip analysis identified several AhR-dependent genes that are suppressed by exposure to nickel. Nickel 93-99 aryl hydrocarbon receptor Homo sapiens 38-41 14645679-5 2003 Using Northern blots, we then confirmed that nickel can down-regulate both the basal and benzo[a]pyrene-inducible expression of AhR-dependent genes in mouse and human cell lines. Nickel 45-51 aryl-hydrocarbon receptor Mus musculus 128-131 14645679-9 2003 Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly or indirectly be involved in the regulation of AhR-dependent transcriptional activity by nickel and other hypoxia-mimicking agents. Nickel 179-185 aryl hydrocarbon receptor Homo sapiens 137-140 14555481-3 2003 The response to nickel ions requires at least one CuRE and also CRR1 function, suggesting that nickel interferes with a component in the nutritional copper signal transduction pathway. Nickel 16-22 uncharacterized protein Chlamydomonas reinhardtii 64-68 14555481-3 2003 The response to nickel ions requires at least one CuRE and also CRR1 function, suggesting that nickel interferes with a component in the nutritional copper signal transduction pathway. Nickel 95-101 uncharacterized protein Chlamydomonas reinhardtii 64-68 14611701-3 2003 The coding region of human TTF2 was cloned into a bacterial expression vector, production of the soluble TTF2 protein optimized, and pure TTF2 obtained by nickel chromatography. Nickel 155-161 forkhead box E1 Homo sapiens 27-31 12960308-0 2003 Infectious nickel tolerance: a reciprocal interplay of tolerogenic APCs and T suppressor cells that is driven by immunization. Nickel 11-17 amyloid P component, serum Homo sapiens 67-71 12960308-2 2003 Here we show that 10(2) T cell-depleted spleen cells (i.e., APCs) from orally tolerized donors can also transfer nickel tolerance. Nickel 113-119 amyloid P component, serum Homo sapiens 60-64 12960308-9 2003 We conclude that T suppressor cells and tolerogenic APCs induced by oral administration of nickel are part of a positive feedback loop that can enhance and maintain tolerance when activated by Ag associated with a danger signal. Nickel 91-97 amyloid P component, serum Homo sapiens 52-56 12865321-1 2003 We reported recently the induction of androgen-dependent iodide uptake activity in the human prostatic adenocarcinoma cell line LNCaP using a prostate-specific antigen (PSA) promoter-directed expression of the sodium iodide symporter (NIS) gene. Nickel 235-238 kallikrein related peptidase 3 Homo sapiens 142-173 12680712-2 2003 Here, we report that the monovalent cations, rubidium and ammonium were able to fully substitute for potassium; while the divalent cations manganese, cobalt, and nickel supported the ATPase activity of GroEL albeit to a lesser degree than magnesium. Nickel 162-168 dynein axonemal heavy chain 8 Homo sapiens 183-189 12680712-2 2003 Here, we report that the monovalent cations, rubidium and ammonium were able to fully substitute for potassium; while the divalent cations manganese, cobalt, and nickel supported the ATPase activity of GroEL albeit to a lesser degree than magnesium. Nickel 162-168 heat shock protein family D (Hsp60) member 1 Homo sapiens 202-207 12680712-3 2003 ATPase activities with manganese, cobalt, and nickel were 64%, 41%, and 29%, respectively, of the maximum activity (100%) when utilizing magnesium. Nickel 46-52 dynein axonemal heavy chain 8 Homo sapiens 0-6 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Nickel 264-270 heat shock protein family D (Hsp60) member 1 Homo sapiens 44-49 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Nickel 264-270 heat shock protein family D (Hsp60) member 1 Homo sapiens 207-212 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Nickel 264-270 heat shock protein family D (Hsp60) member 1 Homo sapiens 207-212 12928406-4 2003 The Ca2+ channel blockers, nickel and econazole, and the K+ channel blockers, tetraethylammonium chloride, apamin, and charybdotoxin, inhibit the granulysin-induced increase in intracellular Ca2+ ([Ca2+](i)), the decrease in intracellular K+, and apoptosis. Nickel 27-33 granulysin Homo sapiens 146-156 12925207-0 2003 T cell receptor transfection shows non-HLA-restricted recognition of nickel by CD8+ human T cells to be mediated by alphabeta T cell receptors. Nickel 69-75 CD8a molecule Homo sapiens 79-82 12925207-1 2003 CD8+ T cells have been assigned a prominent role in allergic contact dermatitis, including nickel allergy; however, human nickel-reactive T cells of the CD8+ phenotype have largely escaped detailed investigation. Nickel 91-97 CD8a molecule Homo sapiens 0-3 12925207-1 2003 CD8+ T cells have been assigned a prominent role in allergic contact dermatitis, including nickel allergy; however, human nickel-reactive T cells of the CD8+ phenotype have largely escaped detailed investigation. Nickel 122-128 CD8a molecule Homo sapiens 153-156 12963341-6 2003 Purification of the desired larger form of pro-CCK is possible using a nickel column with a recovery of about 20%, yielding 500 microg/L media. Nickel 71-77 Drosulfakinin Drosophila melanogaster 47-50 12899628-1 2003 To investigate structure and function relations of a new member of the exchangeable apolipoprotein family that modulates plasma lipid levels, recombinant human apolipoprotein (apo) A-V was produced in Escherichia coli and isolated by a combination of nickel chelation affinity chromatography and reversed-phase HPLC. Nickel 251-257 apolipoprotein A5 Homo sapiens 160-184 12773542-0 2003 Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells. Nickel 0-6 aquaporin 3 (Gill blood group) Homo sapiens 79-90 12773542-6 2003 Sensitivity of AQP3 to nickel was lower at alkaline pH than at neutral and acidic pH. Nickel 23-29 aquaporin 3 (Gill blood group) Homo sapiens 15-19 12773542-9 2003 Three extracellular residues, Trp128, Ser152, and His241, were responsible for the blocking effect of nickel on human AQP3. Nickel 102-108 aquaporin 3 (Gill blood group) Homo sapiens 118-122 12865321-3 2003 In the current study, we examined the regulation of PSA promoter-directed NIS expression and therapeutic effectiveness of (131)I in LNCaP cells by all-trans-retinoic acid (atRA). Nickel 74-77 kallikrein related peptidase 3 Homo sapiens 52-55 12865321-10 2003 In conclusion, treatment with atRA increases NIS expression levels and selective killing effect of (131)I in prostate cancer cells stably expressing NIS under the control of the PSA promoter. Nickel 149-152 kallikrein related peptidase 3 Homo sapiens 178-181 12930308-0 2003 Nickel-induced keratinocyte proliferation and up-modulation of the keratinocyte growth factor receptor expression. Nickel 0-6 fibroblast growth factor receptor 2 Homo sapiens 67-102 12930308-5 2003 Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Nickel 40-46 fibroblast growth factor receptor 2 Homo sapiens 99-135 12930308-5 2003 Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Nickel 40-46 fibroblast growth factor receptor 2 Homo sapiens 137-141 12930308-5 2003 Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Nickel 40-46 epidermal growth factor receptor Homo sapiens 263-267 12930308-5 2003 Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Nickel 40-46 tumor necrosis factor Homo sapiens 287-319 12930308-5 2003 Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Nickel 40-46 transforming growth factor alpha Homo sapiens 321-330 12930308-6 2003 Double immunofluorescence showed that the effect of nickel on DNA synthesis was mainly exerted on KGFR expressing cells, suggesting that KGFR up-modulation could be required for the nickel-induced cell proliferation. Nickel 52-58 fibroblast growth factor receptor 2 Homo sapiens 98-102 12930308-6 2003 Double immunofluorescence showed that the effect of nickel on DNA synthesis was mainly exerted on KGFR expressing cells, suggesting that KGFR up-modulation could be required for the nickel-induced cell proliferation. Nickel 52-58 fibroblast growth factor receptor 2 Homo sapiens 137-141 12930308-6 2003 Double immunofluorescence showed that the effect of nickel on DNA synthesis was mainly exerted on KGFR expressing cells, suggesting that KGFR up-modulation could be required for the nickel-induced cell proliferation. Nickel 182-188 fibroblast growth factor receptor 2 Homo sapiens 98-102 12930308-6 2003 Double immunofluorescence showed that the effect of nickel on DNA synthesis was mainly exerted on KGFR expressing cells, suggesting that KGFR up-modulation could be required for the nickel-induced cell proliferation. Nickel 182-188 fibroblast growth factor receptor 2 Homo sapiens 137-141 12930308-7 2003 These results indicate that KGFR and its ligands may play a role in the mechanism of action of nickel ions and in the protective effect of zinc pretreatment. Nickel 95-101 fibroblast growth factor receptor 2 Homo sapiens 28-32 12950598-5 2003 Recombinant HSP20 protein (rHSP20) was expressed and purified by nickel column. Nickel 65-71 heat shock protein family B (small) member 6 Rattus norvegicus 12-17 12950598-5 2003 Recombinant HSP20 protein (rHSP20) was expressed and purified by nickel column. Nickel 65-71 heat shock protein family B (small) member 6 Rattus norvegicus 27-33 12969564-5 2003 We also describe an optimised method for the expression of soluble, correctly folded MCP-3 in a bacterial system using nickel affinity columns and reverse-phase fast protein liquid chromatography (RP-FPLC), and achieve purified yields of up to 0.4 mg/l of initial culture medium after 5 h of induction. Nickel 119-125 C-C motif chemokine ligand 7 Homo sapiens 85-90 12867553-7 2003 Secondly, recombinant Candida enolase was retained in a nickel-chelating affinity column matrix that can bind (125)I-labelled plasminogen or plasmin in a dose-dependent manner. Nickel 56-62 plasminogen Homo sapiens 126-133 12902198-1 2003 We have previously reported that the gpt transgene in G12 Chinese hamster cells could be silenced by water-insoluble nickel compounds nickel sulfide (NiS) or nickel subsulfide (Ni(3)S(2)) and showed that the transgene was silenced by de novo DNA methylation and chromatin condensation. Nickel 117-123 glutamic--pyruvic transaminase Homo sapiens 37-40 12902198-3 2003 We also analyzed the effects of the DNA methyltransferase inhibitor 5-azacytidine (5-AzaC) and a histone deacetylase inhibitor trichostatin A (TSA) on histone H3 and H4 acetylation and gpt gene expression in selected nickel-silenced clones. Nickel 217-223 glutamic--pyruvic transaminase Homo sapiens 166-188 12902198-9 2003 These data show that gene silencing induced by nickel in the gpt transgenic cell line involved a loss of histone acetylation and an activation of histone methylation. Nickel 47-53 glutamic--pyruvic transaminase Homo sapiens 61-64 12862445-3 2003 These results provide supporting evidence for a biological role for reduced nickel in ACS. Nickel 76-82 acyl-CoA synthetase short chain family member 2 Homo sapiens 86-89 12767066-8 2003 We also observed a marked and specific increase of Cap43 mRNA levels in response to hypoxia or nickel in all VHL-positive cell lines. Nickel 95-101 N-myc downstream regulated 1 Homo sapiens 51-56 12767066-9 2003 Cellular expression of Cap43 mRNA in response to hypoxia or nickel thus is closely associated with VHL gene expression in renal cancer cells. Nickel 60-66 N-myc downstream regulated 1 Homo sapiens 23-28 12853977-6 2003 Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation. Nickel 96-99 ret proto-oncogene Rattus norvegicus 20-23 12853977-6 2003 Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation. Nickel 96-99 ret proto-oncogene Rattus norvegicus 32-35 12853977-6 2003 Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation. Nickel 96-99 ret proto-oncogene Rattus norvegicus 32-35 12853977-7 2003 Accordingly, acute expression of H-Ras(V12) or of a constitutively active MEK1 also blocked TSH-induced expression of Tg and NIS. Nickel 125-128 mitogen activated protein kinase kinase 1 Rattus norvegicus 74-78 12839937-5 2003 Acute exposure to nickel resulted in the accumulation of hypoxia-inducible transcription factor (HIF)-1, which strongly activated hypoxia-inducible genes, including the recently discovered tumor marker NDRG1 (Cap43). Nickel 18-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 57-103 12839937-5 2003 Acute exposure to nickel resulted in the accumulation of hypoxia-inducible transcription factor (HIF)-1, which strongly activated hypoxia-inducible genes, including the recently discovered tumor marker NDRG1 (Cap43). Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 202-207 12839937-5 2003 Acute exposure to nickel resulted in the accumulation of hypoxia-inducible transcription factor (HIF)-1, which strongly activated hypoxia-inducible genes, including the recently discovered tumor marker NDRG1 (Cap43). Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 209-214 12839937-6 2003 To further identify HIF-1-dependent nickel-inducible genes and to understand the role of the HIF-dependent signaling pathway in nickel-induced transformation, we used the Affymetrix GeneChip to compare the gene expression profiles in wild-type cells or in cells from HIF-1 alpha knockout mouse embryos exposed to nickel chloride. Nickel 36-42 hypoxia inducible factor 1 subunit alpha Homo sapiens 20-25 12839937-7 2003 As expected, when we examined 12,000 genes for expression changes, we found that genes coding for glycolytic enzymes and glucose transporters, known to be regulated by HIF-1 transcription factor, were induced by nickel only in HIF-1 alpha-proficient cells. Nickel 212-218 hypoxia inducible factor 1 subunit alpha Homo sapiens 168-173 12839937-7 2003 As expected, when we examined 12,000 genes for expression changes, we found that genes coding for glycolytic enzymes and glucose transporters, known to be regulated by HIF-1 transcription factor, were induced by nickel only in HIF-1 alpha-proficient cells. Nickel 212-218 hypoxia inducible factor 1 subunit alpha Homo sapiens 227-238 12839937-8 2003 In addition, we found a number of other hypoxia-inducible genes up-regulated by nickel in a HIF-dependent manner including BCL-2-binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), and prolyl 4-hydroxylase. Nickel 80-86 BCL2 interacting protein 3 Homo sapiens 145-149 12839937-8 2003 In addition, we found a number of other hypoxia-inducible genes up-regulated by nickel in a HIF-dependent manner including BCL-2-binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), and prolyl 4-hydroxylase. Nickel 80-86 egl-9 family hypoxia inducible factor 1 Homo sapiens 151-156 12839937-8 2003 In addition, we found a number of other hypoxia-inducible genes up-regulated by nickel in a HIF-dependent manner including BCL-2-binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), and prolyl 4-hydroxylase. Nickel 80-86 HIG1 hypoxia inducible domain family member 1A Homo sapiens 158-182 12839937-8 2003 In addition, we found a number of other hypoxia-inducible genes up-regulated by nickel in a HIF-dependent manner including BCL-2-binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), and prolyl 4-hydroxylase. Nickel 80-86 HIG1 hypoxia inducible domain family member 1A Homo sapiens 184-188 12839937-9 2003 Additionally, we found a number of genes induced by nickel in a HIF-independent manner, suggesting that Ni activated other signaling pathways besides HIF-1. Nickel 52-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 150-155 12839937-10 2003 Finally, we found that in HIF-1 alpha knockout cells, nickel strongly induced the expression of the whole group of genes that were not expressed in the presence of HIF-1. Nickel 54-60 hypoxia inducible factor 1 subunit alpha Homo sapiens 26-37 12839937-10 2003 Finally, we found that in HIF-1 alpha knockout cells, nickel strongly induced the expression of the whole group of genes that were not expressed in the presence of HIF-1. Nickel 54-60 hypoxia inducible factor 1 subunit alpha Homo sapiens 26-31 12839937-11 2003 Because the majority of modulated genes were induced or suppressed by nickel in a HIF-1-dependent manner, we elucidated the role of HIF-1 transcription factor in cell transformation. Nickel 70-76 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-87 12839937-11 2003 Because the majority of modulated genes were induced or suppressed by nickel in a HIF-1-dependent manner, we elucidated the role of HIF-1 transcription factor in cell transformation. Nickel 70-76 hypoxia inducible factor 1 subunit alpha Homo sapiens 132-137 12839937-12 2003 In HIF-1 alpha-proficient cells, nickel exposure increased soft agar growth, whereas it decreased soft agar growth in HIF-1 alpha-deficient cells. Nickel 33-39 hypoxia inducible factor 1 subunit alpha Homo sapiens 3-14 12839937-13 2003 We hypothesize that the induction of HIF-1 transcription factor by nickel may be important during the nickel-induced carcinogenic process. Nickel 67-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 37-42 12839937-13 2003 We hypothesize that the induction of HIF-1 transcription factor by nickel may be important during the nickel-induced carcinogenic process. Nickel 102-108 hypoxia inducible factor 1 subunit alpha Homo sapiens 37-42 12859458-8 2003 In nickel-sensitive probands, an average precursor cell frequency of 19x10(5), 1.7x10(5), and 0.7x10(5) could be defined for IFN-gamma, IL-2, and IL-4 producing PBMC, respectively. Nickel 3-9 interferon gamma Homo sapiens 125-134 12859458-8 2003 In nickel-sensitive probands, an average precursor cell frequency of 19x10(5), 1.7x10(5), and 0.7x10(5) could be defined for IFN-gamma, IL-2, and IL-4 producing PBMC, respectively. Nickel 3-9 interleukin 4 Homo sapiens 146-150 12851791-4 2003 We propose a comparative study of the X-ray absorption spectra at the K-edge of iron, copper, zinc and nickel in serotransferrin and ovotransferrin. Nickel 103-109 transferrin Homo sapiens 113-128 12827456-3 2003 Insertion of CGH into a pentapeptide, N-acetyl-Ala-Cys-Gly-His-Ala-CONH(2), allowed the formation of a square-planar thiolato Cys-Gly-His complex with nickel(II) in an internal position of the peptide. Nickel 151-157 hypertrichosis 2 (generalised, congenital) Homo sapiens 13-16 12827456-5 2003 Solutions of CGH-CONH(2) with nickel(II) at neutral pH yielded a red nickel-thiolate complex, but at higher pH (8.5 or above) or with exposure to dioxygen, yellow nickel complexes with N-terminal amino coordination were observed. Nickel 30-36 hypertrichosis 2 (generalised, congenital) Homo sapiens 13-16 12827456-5 2003 Solutions of CGH-CONH(2) with nickel(II) at neutral pH yielded a red nickel-thiolate complex, but at higher pH (8.5 or above) or with exposure to dioxygen, yellow nickel complexes with N-terminal amino coordination were observed. Nickel 69-75 hypertrichosis 2 (generalised, congenital) Homo sapiens 13-16 12827456-5 2003 Solutions of CGH-CONH(2) with nickel(II) at neutral pH yielded a red nickel-thiolate complex, but at higher pH (8.5 or above) or with exposure to dioxygen, yellow nickel complexes with N-terminal amino coordination were observed. Nickel 69-75 hypertrichosis 2 (generalised, congenital) Homo sapiens 13-16 12834484-4 2003 Immunohistochemical staining of CD171 and CD24 was performed by the streptavidin-biotin-peroxidase-complex technique and a nickel-enhanced diaminobenzidine (DAB) reaction using the monoclonal antibodies UJ 127.11 and ML-5, respectively. Nickel 123-129 L1 cell adhesion molecule Homo sapiens 32-37 12821321-5 2003 Purified recombinant transthyretin was obtained by one-step nickel chelation affinity chromatography and the production level of the protein was 130mg per 1L of culture. Nickel 60-66 transthyretin Homo sapiens 21-34 12711602-5 2003 Here we report that one mutant, I306C(TM5) showed increased ATPase activity (8-fold higher than untreated) when treated with MTS-verapamil and isolated by nickel-chelate chromatography. Nickel 155-161 dynein axonemal heavy chain 8 Homo sapiens 60-66 16256507-1 2003 The synthesis of nickel nanoparticles by the hydrazine reduction of nickel chloride in ethylene glycol at 60 degrees C without soluble polymer as a protective agent was studied. Nickel 17-23 cullin associated and neddylation dissociated 1 Homo sapiens 117-118 12846418-6 2003 Similarly, a ligand for proliferator-activated receptor gamma (PPARgamma) when combined with 9-cis RA synergistically increased both NIS mRNA levels and iodide uptake in these MCF-7 cells. Nickel 133-136 peroxisome proliferator activated receptor gamma Homo sapiens 24-73 12756270-0 2003 A new type of metal recognition by human T cells: contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel. Nickel 159-165 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 103-118 12650758-4 2003 Indeed, nPhl p 6 could be highly enriched in one step using nickel-chelating Sepharose. Nickel 60-66 S100 calcium binding protein A12 Homo sapiens 13-16 12562760-6 2003 ure2 Delta mutants are hypersensitive to cadmium and nickel ions and hydrogen peroxide. Nickel 53-59 glutathione peroxidase Saccharomyces cerevisiae S288C 0-4 12679773-9 2003 A rise in mean serum levels of nickel was observed, from 0.47 ng/mL before implantation to 1.27 ng/mL (24 hours after), to a maximum of 1.50 ng/mL 1 month after implantation, which was statistically significant (P =.008 and P = 0.022, Wilcoxon Test). Nickel 31-37 L1 cell adhesion molecule Mus musculus 144-148 12729250-3 2003 Our investigations using synthetic peptide models have resulted in identification of nickel-binding sites in core histones H3 and H2A and in protamine P2. Nickel 85-91 H2A clustered histone 18 Homo sapiens 130-133 12729255-8 2003 For example, both nickel compounds activated a number of transcription factors including hypoxia-inducible factor I (HIF-1) and p53. Nickel 18-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 117-122 12729255-8 2003 For example, both nickel compounds activated a number of transcription factors including hypoxia-inducible factor I (HIF-1) and p53. Nickel 18-24 tumor protein p53 Homo sapiens 128-131 12729255-10 2003 The obtained data are in agreement with our previous observations that acute nickel exposure activates HIF-1 and p53 transcription factors and in nickel-transformed cells, the ratio of HIF-I activity to p53 activity was shifted towards high HIF-I activity. Nickel 77-83 hypoxia inducible factor 1 subunit alpha Homo sapiens 103-108 12729255-10 2003 The obtained data are in agreement with our previous observations that acute nickel exposure activates HIF-1 and p53 transcription factors and in nickel-transformed cells, the ratio of HIF-I activity to p53 activity was shifted towards high HIF-I activity. Nickel 77-83 tumor protein p53 Homo sapiens 113-116 12729255-10 2003 The obtained data are in agreement with our previous observations that acute nickel exposure activates HIF-1 and p53 transcription factors and in nickel-transformed cells, the ratio of HIF-I activity to p53 activity was shifted towards high HIF-I activity. Nickel 77-83 tumor protein p53 Homo sapiens 203-206 12729255-10 2003 The obtained data are in agreement with our previous observations that acute nickel exposure activates HIF-1 and p53 transcription factors and in nickel-transformed cells, the ratio of HIF-I activity to p53 activity was shifted towards high HIF-I activity. Nickel 146-152 tumor protein p53 Homo sapiens 203-206 12651007-3 2003 The Cpn60 proteins were purified to apparent homogeneity using a combination of nickel column affinity chromatography and Reactive Red dye affinity columns. Nickel 80-86 heat shock protein family D (Hsp60) member 1 Homo sapiens 4-9 12614157-3 2003 Nuclear uptake of biotinylated recombinant His-tagged Rev-GFP was assessed in nuclear extracts from digitonin-permeabilized cells by binding to either importin beta-receptors or nickel molecules immobilized on a microtiter plate. Nickel 178-184 Rev Human immunodeficiency virus 1 54-57 12753426-7 2003 This indicates that DMT1 is responsible for the apical transport of these metals in the intestinal epithelium and suggests that adequate iron intake and status will limit nickel absorption. Nickel 171-177 solute carrier family 11 member 2 Homo sapiens 20-24 12540486-4 2003 Initial microarray analysis of nickel-induced gene expression of saline-treated mice revealed increased inflammatory mediator, matrix injury-repair, and hypoxia-induced factor-mediated sequences and decreased lung-specific (e.g., surfactant-associated protein B and C) sequences. Nickel 31-37 surfactant associated protein B Mus musculus 230-267 12588196-0 2003 Mechanism of nickel assault on the zinc finger of DNA repair protein XPA. Nickel 13-19 XPA, DNA damage recognition and repair factor Homo sapiens 69-72 12427746-4 2003 Evidence from nickel-nitrilotriacetic acid pull-down experiments demonstrates a highly stable Rad51B.Rad51C heterodimer, which interacts weakly with Rad51. Nickel 14-20 RAD51 paralog B Homo sapiens 94-100 12427746-4 2003 Evidence from nickel-nitrilotriacetic acid pull-down experiments demonstrates a highly stable Rad51B.Rad51C heterodimer, which interacts weakly with Rad51. Nickel 14-20 RAD51 paralog C Homo sapiens 101-107 12427746-4 2003 Evidence from nickel-nitrilotriacetic acid pull-down experiments demonstrates a highly stable Rad51B.Rad51C heterodimer, which interacts weakly with Rad51. Nickel 14-20 RAD51 recombinase Homo sapiens 94-99 12297508-2 2002 By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian APH-1 (mAPH-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. Nickel 36-42 aph-1 homolog A, gamma-secretase subunit Homo sapiens 101-106 12694855-7 2003 Incubation of rmMBPDeltaN and rmMBPDeltaC under monolayers comprising phosphatidylinositol-4-phosphate and a nickel-chelating lipid yielded tubular structures of opposite chirality, suggesting a synergistic effect of both termini of MBP in organizing myelin lipids. Nickel 109-115 myelin basic protein Mus musculus 16-19 12895515-3 2003 Local reverse dialysis administration of 0.1-10 microM of the Ca(v)2.3 inhibitor SNX-482, or 100 microM of mibefradil, decreased the concentrations of dopamine and its metabolites in dialysate from substantia nigra, whereas 1 microM mibefradil or 40-80 microM nickel(II) induced an increase in nigral dialysate dopamine concentrations. Nickel 260-266 calcium voltage-gated channel subunit alpha1 E Rattus norvegicus 62-70 20021188-3 2003 We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response. Nickel 33-39 interleukin 1 alpha Homo sapiens 113-117 12452719-5 2002 The Mn(II)-Ni(II) weak ferromagnetic coupling in the chain is interpreted in a spin delocalization mechanism as resulting from the weakness of the overlap between the magnetic orbitals centered on nickel and those centered on manganese which are only weakly delocalized on the ligands. Nickel 197-203 spindlin 1 Homo sapiens 79-83 12297508-2 2002 By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian APH-1 (mAPH-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. Nickel 36-42 alphaprotein 1 Mus musculus 108-114 12518250-6 2002 Under basal conditions NIS expression varied from 83 to 593 copies per 10 6 GAPDH molecules. Nickel 23-26 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 76-81 18968797-9 2002 The method was applied for the determination of nickel in samples of tap and mineral water. Nickel 48-54 nuclear RNA export factor 1 Homo sapiens 69-72 12323399-4 2002 Fab fragments produced in Escherichia coli were purified by a single step of nickel-chelate affinity chromatography via a hexa-histidine tag. Nickel 77-83 FA complementation group B Homo sapiens 0-3 12426116-2 2002 In these organisms, nickel is involved in enzymes that catalyze both non-redox (e.g., urease, glyoxalase I) and redox (e.g., hydrogenase, carbon monoxide dehydrogenase, superoxide dismutase) reactions, and proteins involved in the transport, storage, metallocenter assembly, and regulation of nickel concentration have evolved. Nickel 20-26 glyoxalase I Homo sapiens 94-106 12426116-2 2002 In these organisms, nickel is involved in enzymes that catalyze both non-redox (e.g., urease, glyoxalase I) and redox (e.g., hydrogenase, carbon monoxide dehydrogenase, superoxide dismutase) reactions, and proteins involved in the transport, storage, metallocenter assembly, and regulation of nickel concentration have evolved. Nickel 293-299 glyoxalase I Homo sapiens 94-106 12426123-3 2002 Whereas numerous carcinogens have previously been shown to be mutagenic in these cells, a few carcinogens, including nickel, diethylstilbestrol, and X-rays, are also capable of silencing the G12 cell gpt transgene by aberrant DNA methylation. Nickel 117-123 glutamic--pyruvic transaminase Homo sapiens 200-203 12426141-2 2002 Acute exposure to nickel activates hypoxia-inducible transcription factor-1 (HIF-1), which strongly induces hypoxia-inducible genes, including the recently discovered tumor marker Cap43. Nickel 18-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 35-75 12426141-2 2002 Acute exposure to nickel activates hypoxia-inducible transcription factor-1 (HIF-1), which strongly induces hypoxia-inducible genes, including the recently discovered tumor marker Cap43. Nickel 18-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 77-82 12426141-2 2002 Acute exposure to nickel activates hypoxia-inducible transcription factor-1 (HIF-1), which strongly induces hypoxia-inducible genes, including the recently discovered tumor marker Cap43. Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 180-185 12426141-4 2002 To identify other HIF-1-dependent/independent nickel-inducible genes, we used cells obtained from HIF-1 alpha null mouse embryos and analyzed gene expression changes using the microarray technique. Nickel 46-52 hypoxia inducible factor 1 subunit alpha Homo sapiens 18-23 12426141-5 2002 We found that genes coding for glycolytic enzymes, known to be regulated by HIF-1, were also induced in nickel-exposed cells. Nickel 104-110 hypoxia inducible factor 1 subunit alpha Homo sapiens 76-81 12426141-7 2002 Elevated HIF-1 activity after acute nickel exposure might be selectively advantageous because nickel-transformed rodent and human cells possess increased HIF-1 transcriptional activity. Nickel 36-42 hypoxia inducible factor 1 subunit alpha Homo sapiens 9-14 12426141-7 2002 Elevated HIF-1 activity after acute nickel exposure might be selectively advantageous because nickel-transformed rodent and human cells possess increased HIF-1 transcriptional activity. Nickel 36-42 hypoxia inducible factor 1 subunit alpha Homo sapiens 154-159 12426141-7 2002 Elevated HIF-1 activity after acute nickel exposure might be selectively advantageous because nickel-transformed rodent and human cells possess increased HIF-1 transcriptional activity. Nickel 94-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 9-14 12426141-7 2002 Elevated HIF-1 activity after acute nickel exposure might be selectively advantageous because nickel-transformed rodent and human cells possess increased HIF-1 transcriptional activity. Nickel 94-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 154-159 12426142-3 2002 We have investigated the possible activation of activator protein-1 (AP-1) and nuclear factor KB (NF-kappaB) in mouse C141 epidermal cells and fibroblasts 3T3 and B82, and human bronchoepithelial BEAS-2B cells in response to nickel compound exposure. Nickel 225-231 jun proto-oncogene Mus musculus 48-67 12426142-4 2002 Our results show that NF-kappaB activity is induced by nickel exposure in 3T3 and BEAS-2B cells. Nickel 55-61 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 22-31 12426142-5 2002 Conversely, similar nickel treatment of these cells did not induce AP-1 activity, suggesting that nickel tumorigenesis occurs through NF-kappaB and not AP-1. Nickel 98-104 nuclear factor kappa B subunit 1 Homo sapiens 134-143 12426142-6 2002 We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants. Nickel 72-78 nuclear factor kappa B subunit 1 Homo sapiens 33-42 12426142-6 2002 We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants. Nickel 72-78 N-myc downstream regulated 1 Homo sapiens 63-68 12426144-8 2002 Fragment R1-2 was 90% homologous to a fragment of the DRIP/TRAP-80 (vitamin D receptor interacting protein/thyroid hormone receptor-activating protein 80) genes and was expressed in nontransformed but not in nickel-transformed cell lines. Nickel 208-214 ribonucleotide reductase M2 Mus musculus 9-13 12383867-5 2002 Removal of extracellular calcium eliminated CCK-induced [Ca(2+)](i) increments, as did the addition of the calcium channel inhibitors nickel (1mM) and lanthanum (5mM). Nickel 134-140 cholecystokinin Cavia porcellus 44-47 12487772-10 2002 It can be speculated that a low-iodine content of mother"s milk because of inhibition of NIS in the mammary gland may be one factor of importance for development of myxedematous cretinism. Nickel 89-92 Weaning weight-maternal milk Bos taurus 59-63 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel 49-55 interleukin 5 Homo sapiens 156-160 12270829-8 2002 An Escherichia coli nikA insertion mutant recovered nickel uptake ability following heterologous complementation with either the ynt or the ureH plasmid-borne gene of Y. pseudotuberculosis, demonstrating that each carrier is necessary and sufficient for nickel transport. Nickel 52-58 relaxosome component Escherichia coli 20-24 12270829-8 2002 An Escherichia coli nikA insertion mutant recovered nickel uptake ability following heterologous complementation with either the ynt or the ureH plasmid-borne gene of Y. pseudotuberculosis, demonstrating that each carrier is necessary and sufficient for nickel transport. Nickel 254-260 relaxosome component Escherichia coli 20-24 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel 49-55 interleukin 13 Homo sapiens 162-167 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel 49-55 interferon gamma Homo sapiens 172-188 12207582-10 2002 The number of IL-4- and IL-5-producing cells correlated with the number of IL-13-producing cells in the nickel-allergic patients, but Ni2+-induced PBMC proliferation did not correlate with the number of cytokine-producing cells for any of the cytokines tested. Nickel 104-110 interleukin 4 Homo sapiens 14-28 12021185-6 2002 Moreover, hCG increased both NIS mRNA after 2 h and NIS protein levels after 4 h, reaching a maximum after 8 h in both cases. Nickel 29-32 chorionic gonadotropin subunit beta 5 Homo sapiens 10-13 12213016-3 2002 This confirms earlier observations suggesting that drying DNA fragments on mica in the presence of nickel induces limited conformational changes. Nickel 99-105 MHC class I polypeptide-related sequence A Homo sapiens 75-79 12097013-0 2002 Spin-wave quantization in ferromagnetic nickel nanowires. Nickel 40-46 spindlin 1 Homo sapiens 0-4 11978798-0 2002 A novel pathway for nickel-induced interleukin-8 expression. Nickel 20-26 C-X-C motif chemokine ligand 8 Homo sapiens 35-48 11978798-7 2002 Transfection with truncated IL-8 promoter constructs linked to the luciferase gene demonstrated that nickel-induced IL-8 transcription required -272 bp of the promoter relative to the transcriptional start site. Nickel 101-107 C-X-C motif chemokine ligand 8 Homo sapiens 28-32 11978798-7 2002 Transfection with truncated IL-8 promoter constructs linked to the luciferase gene demonstrated that nickel-induced IL-8 transcription required -272 bp of the promoter relative to the transcriptional start site. Nickel 101-107 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 11978798-9 2002 Transfection with a dominant negative AP-1 construct or mutation of the AP-1, GATA, or C/EBP sites in the -272-bp IL-8 promoter construct blocked induction by nickel. Nickel 159-165 CCAAT enhancer binding protein alpha Homo sapiens 87-92 11978798-9 2002 Transfection with a dominant negative AP-1 construct or mutation of the AP-1, GATA, or C/EBP sites in the -272-bp IL-8 promoter construct blocked induction by nickel. Nickel 159-165 C-X-C motif chemokine ligand 8 Homo sapiens 114-118 11978798-10 2002 Inhibiting ERK, phosphatidylinositol 3-kinase, but not p38 kinase, diacylglycerol kinase, or hypoxia-inducible factor-1alpha, attenuated nickel induction of IL-8. Nickel 137-143 mitogen-activated protein kinase 1 Homo sapiens 11-14 11978798-10 2002 Inhibiting ERK, phosphatidylinositol 3-kinase, but not p38 kinase, diacylglycerol kinase, or hypoxia-inducible factor-1alpha, attenuated nickel induction of IL-8. Nickel 137-143 C-X-C motif chemokine ligand 8 Homo sapiens 157-161 11978798-11 2002 These studies indicate that nickel induced IL-8 transcription through a novel pathway that requires both AP-1 and non-traditional transcription factors. Nickel 28-34 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 12081959-11 2002 39:176-182, 2001) that HypA cooperates with HypB in the insertion of nickel into the precursor of the large hydrogenase subunit. Nickel 69-75 hypA Escherichia coli 23-27 12137958-1 2002 Transformation of yeast cells with a maize cDNA ZmPAA, encoding a 20S proteasome alpha-subunit, conferred resistance to nickel, cadmium and cobalt. Nickel 120-126 maize 20S proteasome alpha subunit Zea mays 48-53 12137958-3 2002 The abundance of the ZmPAA mRNA was increased in the shoots of maize plants upon nickel treatment. Nickel 81-87 maize 20S proteasome alpha subunit Zea mays 21-26 12054988-2 2002 The synthesis and characterization of dicopper(II) and dinickel(II) complexes of DPD completes a homologous series of homobimetallic zinc(II), copper(II), and nickel(II) complexes for both cofacial platforms. Nickel 57-63 dihydropyrimidine dehydrogenase Homo sapiens 81-84 12021185-6 2002 Moreover, hCG increased both NIS mRNA after 2 h and NIS protein levels after 4 h, reaching a maximum after 8 h in both cases. Nickel 52-55 chorionic gonadotropin subunit beta 5 Homo sapiens 10-13 12010971-3 2002 Here it is demonstrated that the HP1338 protein, an ortholog of the Escherichia coli nickel regulatory protein NikR, mediates nickel-responsive induction of urease expression in H. pylori. Nickel 85-91 nickel-responsive transcriptional regulator NikR Helicobacter pylori 26695 33-39 12010971-3 2002 Here it is demonstrated that the HP1338 protein, an ortholog of the Escherichia coli nickel regulatory protein NikR, mediates nickel-responsive induction of urease expression in H. pylori. Nickel 126-132 nickel-responsive transcriptional regulator NikR Helicobacter pylori 26695 33-39 16290640-1 2002 We used an atomic force microscope to investigate silicon nitride tip interactions with various materials (copper, nickel, silicon carbide) as a function of pH. Nickel 115-121 TOR signaling pathway regulator Homo sapiens 66-69 12060402-0 2002 Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis. Nickel 0-6 CD4 molecule Homo sapiens 16-19 12060402-3 2002 Here the migration of cutaneous lymphocyte-associated antigen+, nickel-specific CD8(+) and CD4(+) T cell lines were compared with a panel of chemokines produced in the skin during allergic contact dermatitis. Nickel 64-70 CD8a molecule Homo sapiens 80-83 12060402-7 2002 Moreover, CCR4 expression was high on nickel-specific T helper 2, intermediate on T helper 1 and T cytotoxic 2, and almost undetectable on T cytotoxic 1 clones. Nickel 38-44 C-C motif chemokine receptor 4 Homo sapiens 10-14 11971748-1 2002 OBJECTIVE: The aim of the present experiments was to elucidate: 1. the stability and usefulness of a 3,3 -diaminobenzidine tetrahydrochloride (DAB) chromogen intensified with nickel and cobalt (DAB-Ni-Co) in the dual immunocytochemical and in situ hybridization procedure using Fos-protein antibody and oxytocin mRNA (OXY mRNA) radiolabeled probe; 2. the susceptibility of the free floating and mounted cryostat sections, freshly prepared or stored for 24 month at -20 degrees C. METHODS: The dual staining procedure was tested on neurons of the hypothalamic paraventricular nucleus (PVN) activated by an intraperitoneal injection of hypertonic saline (HS, 1.5 M, 5 ml, 60 min). Nickel 175-181 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 278-281 11960446-3 2002 Nickel complexes bearing no phosphine ligands, such as NiCl2, Ni(acac)2, and Ni(COD)2, afford the coupling products in good yields, whereas NiCl2(PPh3)2 and NiCl2(dppp) were less effective. Nickel 0-6 COD2 Homo sapiens 80-85 11919079-0 2002 Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha. Nickel 29-35 tumor necrosis factor Homo sapiens 92-124 11919079-4 2002 After 72 h of nickel exposure (70 microg Ni/m3), transgenic lines with intermediate levels of the TGF-alpha expression demonstrated attenuation of lung injury. Nickel 14-20 transforming growth factor alpha Mus musculus 98-107 11919079-6 2002 In the TGF-alpha transgenic mouse model, TGF-alpha protects against nickel-induced acute lung injury, at least in part, by attenuating the inflammatory response, reducing pulmonary edema, and preserving levels of SP-B. Nickel 68-74 transforming growth factor alpha Mus musculus 7-16 11919079-6 2002 In the TGF-alpha transgenic mouse model, TGF-alpha protects against nickel-induced acute lung injury, at least in part, by attenuating the inflammatory response, reducing pulmonary edema, and preserving levels of SP-B. Nickel 68-74 transforming growth factor alpha Mus musculus 41-50 12028813-11 2002 The level of CINC/GRO recovered to that of the control group on day 3 after cessation of the nickel aerosol exposure. Nickel 93-99 C-X-C motif chemokine ligand 1 Rattus norvegicus 18-21 11896730-0 2002 Synthesis, structures, and magnetic properties of heterodimetal bis(mu-hydroxo)chromium(III)nickel(II) complexes with Tpa derivatives having sterically bulky substituents. Nickel 92-98 plasminogen activator, tissue type Homo sapiens 118-121 11896730-3 2002 Chromium and nickel ions are coordinated by two phen"s and Me(n)-tpa, respectively, to complete a distorted octahedral coordination sphere. Nickel 13-19 plasminogen activator, tissue type Homo sapiens 65-68 11971748-1 2002 OBJECTIVE: The aim of the present experiments was to elucidate: 1. the stability and usefulness of a 3,3 -diaminobenzidine tetrahydrochloride (DAB) chromogen intensified with nickel and cobalt (DAB-Ni-Co) in the dual immunocytochemical and in situ hybridization procedure using Fos-protein antibody and oxytocin mRNA (OXY mRNA) radiolabeled probe; 2. the susceptibility of the free floating and mounted cryostat sections, freshly prepared or stored for 24 month at -20 degrees C. METHODS: The dual staining procedure was tested on neurons of the hypothalamic paraventricular nucleus (PVN) activated by an intraperitoneal injection of hypertonic saline (HS, 1.5 M, 5 ml, 60 min). Nickel 175-181 oxytocin/neurophysin I prepropeptide Homo sapiens 303-311 15344310-3 2002 In this study, we examined, by means of western blots, the protein expression of Smad4 during rat testicular development and its cellular localization by immunohistochemical ABC method with glucose oxidase-DAB-nickel enhancement technique. Nickel 210-216 SMAD family member 4 Rattus norvegicus 81-86 11818505-2 2002 IGF-I did not modify NIS mRNA levels but inhibited TSH- and forskolin-induced NIS mRNA expression in a dose-dependent manner. Nickel 78-81 insulin-like growth factor 1 Rattus norvegicus 0-5 11813209-1 2002 BACKGROUND: The sodium iodide symporter (NIS) mediates iodide uptake in thyroid follicular cells and provides a mechanism for effective radioiodide treatment of residual, recurrent, and metastatic thyroid cancers. Nickel 41-44 solute carrier family 5 member 5 Rattus norvegicus 16-39 11827525-2 2002 ACS contains an active site nickel iron-sulfur cluster that forms a paramagnetic adduct with CO, called the nickel iron carbon (NiFeC) species, which we have hypothesized to be a key intermediate in acetyl-CoA synthesis. Nickel 28-34 acyl-CoA synthetase short chain family member 2 Homo sapiens 0-3 11818505-3 2002 We explored the signaling pathways by which IGF-I mediates the repression of NIS expression. Nickel 77-80 insulin-like growth factor 1 Rattus norvegicus 44-49 11779168-0 2002 Cobalt- and nickel-binding property of cullin-2. Nickel 12-18 cullin 2 Homo sapiens 39-47 11779168-1 2002 Treatment with divalent metal ions such as cobalt (Co(2+)) or nickel (Ni(2+)) result in the stabilization of hypoxia-inducible factor-1alpha (HIF1alpha). Nickel 62-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 109-140 11779168-1 2002 Treatment with divalent metal ions such as cobalt (Co(2+)) or nickel (Ni(2+)) result in the stabilization of hypoxia-inducible factor-1alpha (HIF1alpha). Nickel 62-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 142-151 11751209-0 2002 The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. Nickel 48-54 TYRO3 protein tyrosine kinase 3 Mus musculus 16-40 11751209-0 2002 The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. Nickel 48-54 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Mus musculus 41-44 11751209-5 2002 Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Nickel 26-32 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Mus musculus 0-3 11751209-5 2002 Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Nickel 26-32 interleukin 6 Mus musculus 89-102 11751209-5 2002 Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Nickel 26-32 chemokine (C-C motif) ligand 2 Mus musculus 104-138 11751209-5 2002 Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Nickel 26-32 chemokine (C-X-C motif) ligand 2 Mus musculus 144-177 11841829-1 2002 Binary lipid monolayers consisting of equimolar proportions of a phosphoinositide and a nickel-chelating lipid formed helical tubular vesicular structures, which appeared to be induced and/or stabilized by myelin basic protein (MBP). Nickel 88-94 myelin basic protein Homo sapiens 206-226 11841829-1 2002 Binary lipid monolayers consisting of equimolar proportions of a phosphoinositide and a nickel-chelating lipid formed helical tubular vesicular structures, which appeared to be induced and/or stabilized by myelin basic protein (MBP). Nickel 88-94 myelin basic protein Homo sapiens 228-231 12239992-0 2001 Reactivity in polynuclear transition metal chemistry as a means to obtain high-spin molecules: substitution of mu 4-OH- by eta 1,mu 4-N3- increases nine times the ground-state S value of a nonanuclear nickel(II) cage. Nickel 201-207 secreted phosphoprotein 1 Homo sapiens 123-128 11739191-3 2001 The nickel-agarose-purified His-M195FANCF protein bound specifically to the surface of HeLa cells transfected with CD33 and internalized through vesicular structures. Nickel 4-10 FA complementation group F Homo sapiens 36-41 11739191-3 2001 The nickel-agarose-purified His-M195FANCF protein bound specifically to the surface of HeLa cells transfected with CD33 and internalized through vesicular structures. Nickel 4-10 CD33 molecule Homo sapiens 115-119 11739495-7 2001 As few as 10(2) bulk T cells, consisting of both CD4(+) and CD8(+) cells, were able to specifically transfer tolerance to nickel. Nickel 122-128 CD4 antigen Mus musculus 49-52 11775675-1 2001 Reaction of the dinuclear M(II)-bis(mu-hydroxo) complexes of nickel and cobalt, [(M(II)(TpR)]2(mu-OH)2] (M = Ni; 3Ni M = Co: 3Co), with one equivalent of H2O2 yields the corresponding M(III)-bis(mu-oxo) complexes, [[M(III)(TpR)]2-(mu-O)2] (M=Ni; 2Ni, M=Co: 2Co). Nickel 61-67 translocated promoter region, nuclear basket protein Homo sapiens 88-91 11775675-4 2001 Characteristic features of the nickel complexes 2Ni, such as the two intense absorptions around 400 and 300 nm in the UV-visible spectra and the apparent diamagnetism, are very similar to those of the previously reported bis(mu-oxo) species of Cu(III) and Ni(III) with ligands other than TpR, whereas the spectroscopic properties of the cobalt complexes 2Co (i.e., paramagnetically shifted NMR signals and a single intense absorption appearing at 350 nm) are clearly distinct from those of the isostructural nickel compounds 2Ni. Nickel 31-37 translocated promoter region, nuclear basket protein Homo sapiens 288-291 11683635-1 2001 Acetogenic bacteria contain acetyl-CoA synthase (ACS), an enzyme with two distinct nickel-iron-sulfur active sites connected by a tunnel through which CO migrates. Nickel 83-89 acyl-CoA synthetase short chain family member 2 Homo sapiens 28-47 11683635-1 2001 Acetogenic bacteria contain acetyl-CoA synthase (ACS), an enzyme with two distinct nickel-iron-sulfur active sites connected by a tunnel through which CO migrates. Nickel 83-89 acyl-CoA synthetase short chain family member 2 Homo sapiens 49-52 11504687-0 2001 Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 16-48 11733942-5 2001 With major interfering currents inhibited, I(NaCa) was measured as the current sensitive to nickel (Ni; 10mM) during a descending voltage ramp. Nickel 92-98 nascent polypeptide-associated complex subunit alpha Cavia porcellus 45-49 11739637-3 2001 Other than hypoxia, cobalt and nickel, which can substitute for iron in the ferroprotein, induce the stabilization of HIF-1alpha and the activation of HIF-1. Nickel 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-128 11739637-3 2001 Other than hypoxia, cobalt and nickel, which can substitute for iron in the ferroprotein, induce the stabilization of HIF-1alpha and the activation of HIF-1. Nickel 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-123 11704812-1 2001 Radioiodine therapy, the most effective form of systemic radiotherapy available, is currently useful only for thyroid cancer because of thyroid-specific expression of the sodium iodide symporter (NIS). Nickel 196-199 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 171-194 11504687-7 2001 Pretreating cells with antisense, but not sense, oligonucleotides to HIF-1 alpha mRNA abolished nickel-stimulated increases in PAI-1 mRNA. Nickel 96-102 hypoxia inducible factor 1 subunit alpha Homo sapiens 69-80 11504687-7 2001 Pretreating cells with antisense, but not sense, oligonucleotides to HIF-1 alpha mRNA abolished nickel-stimulated increases in PAI-1 mRNA. Nickel 96-102 serpin family E member 1 Homo sapiens 127-132 11504687-8 2001 These data indicate that signaling through extracellular signal-regulated kinase and HIF-1 alpha is required for nickel-induced transcriptional activation of PAI-1. Nickel 113-119 hypoxia inducible factor 1 subunit alpha Homo sapiens 85-96 11504687-8 2001 These data indicate that signaling through extracellular signal-regulated kinase and HIF-1 alpha is required for nickel-induced transcriptional activation of PAI-1. Nickel 113-119 serpin family E member 1 Homo sapiens 158-163 11504688-0 2001 AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Nickel 65-71 serpin family E member 1 Homo sapiens 28-61 11504688-2 2001 Nickel may promote fibrosis by transcriptionally activating plasminogen activator inhibitor (PAI)-1 and inhibiting fibrinolysis. Nickel 0-6 serpin family E member 1 Homo sapiens 60-99 11504688-3 2001 The current studies examined whether nickel stimulated the PAI-1 promoter though an oxidant-sensitive activator protein (AP)-1 signaling pathway. Nickel 37-43 serpin family E member 1 Homo sapiens 59-64 11504688-4 2001 Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation, induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated PAI-1 mRNA levels over a 24-h time course. Nickel 12-18 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 104-109 11504688-4 2001 Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation, induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated PAI-1 mRNA levels over a 24-h time course. Nickel 12-18 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 114-119 11504688-4 2001 Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation, induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated PAI-1 mRNA levels over a 24-h time course. Nickel 12-18 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 162-167 11504688-4 2001 Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation, induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated PAI-1 mRNA levels over a 24-h time course. Nickel 12-18 serpin family E member 1 Homo sapiens 197-202 11504688-6 2001 Expression of the dominant negative inhibitor of AP-1, TAM67, prevented nickel-stimulated AP-1 DNA binding, AP-1-luciferase reporter construct activity, and PAI-1 mRNA levels. Nickel 72-78 serpin family E member 1 Homo sapiens 157-162 11504688-8 2001 These data indicated that nickel activated AP-1 through an oxidant-independent pathway and that basal AP-1 is necessary for nickel-induced expression of PAI-1. Nickel 124-130 serpin family E member 1 Homo sapiens 153-158 11547352-0 2001 External nickel blocks human Kv1.5 channels stably expressed in CHO cells. Nickel 9-15 potassium voltage-gated channel subfamily A member 5 Homo sapiens 29-34 11547352-1 2001 We have investigated the actions of Nickel (Ni(2+)) on a human cardiac potassium channel (hKv1.5), the main component of human atrial ultra-rapid delayed rectifier current, stably expressed in Chinese hamster ovary cell line using the whole-cell voltage-clamp technique. Nickel 36-42 potassium voltage-gated channel subfamily A member 5 Homo sapiens 90-96 11511266-0 2001 Scope and limitation of organocuprates, and copper or nickel catalyst-modified Grignard reagents for installation of an alkyl group onto cis-4-cyclopentene-1,3-diol monoacetate. Nickel 54-60 suppressor of cytokine signaling 6 Homo sapiens 137-142 11470494-1 2001 We have previously reported that nickel (Ni)-silenced expression of the URA3 gene in yeast (Saccharomyces cerevisiae) and gpt transgene in G12 Chinese hamster cells. Nickel 33-39 orotidine-5'-phosphate decarboxylase Saccharomyces cerevisiae S288C 72-76 11571539-8 2001 In contrast, the combination of NIS and TPO gene transfer, with resulting TPO-mediated organification and intracellular retention of radioiodide, may lead to more effective tumor cell death. Nickel 32-35 thyroid peroxidase Homo sapiens 74-77 11571539-9 2001 Thus, TPO could be used as a therapeutic strategy to enhance the NIS-based radioiodide concentrator gene therapy for locally advanced lung cancer. Nickel 65-68 thyroid peroxidase Homo sapiens 6-9 11504687-0 2001 Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Nickel 0-6 serpin family E member 1 Homo sapiens 81-114 11504687-3 2001 Because nickel is known to mimic hypoxia, the present study examined whether nickel transcriptionally activates PAI-1 through the hypoxia-inducible factor (HIF)-1 alpha signaling pathway. Nickel 77-83 serpin family E member 1 Homo sapiens 112-117 11504687-4 2001 The involvement of the NADPH oxidase complex, reactive oxygen species, and kinases in mediating nickel-induced HIF-1 alpha signaling was also investigated. Nickel 96-102 hypoxia inducible factor 1 subunit alpha Homo sapiens 111-122 11504687-5 2001 Addition of nickel to BEAS-2B human airway epithelial cells increased HIF-1 alpha protein levels and elevated PAI-1 mRNA levels. Nickel 12-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 70-81 11504687-5 2001 Addition of nickel to BEAS-2B human airway epithelial cells increased HIF-1 alpha protein levels and elevated PAI-1 mRNA levels. Nickel 12-18 serpin family E member 1 Homo sapiens 110-115 11504687-6 2001 Pretreatment of cells with the extracellular signal-regulated kinase inhibitor U-0126 partially blocked HIF-1 alpha protein and PAI-1 mRNA levels induced by nickel, whereas antioxidants and NADPH oxidase inhibitors had no effect. Nickel 157-163 hypoxia inducible factor 1 subunit alpha Homo sapiens 104-115 11504687-6 2001 Pretreatment of cells with the extracellular signal-regulated kinase inhibitor U-0126 partially blocked HIF-1 alpha protein and PAI-1 mRNA levels induced by nickel, whereas antioxidants and NADPH oxidase inhibitors had no effect. Nickel 157-163 serpin family E member 1 Homo sapiens 128-133 11472983-4 2001 TRAIL (codons 95-285) was expressed in a bacterial expression vector and purified by nickel affinity chromatography. Nickel 85-91 TNF superfamily member 10 Homo sapiens 0-5 11416051-6 2001 The improved ICC method using the silver-gold intensification of nickel-diaminobenzidine chromogen, enabled the observation of nuclear ER-beta-immunoreactivity in the majority of LHRH cells. Nickel 65-71 estrogen receptor 2 Rattus norvegicus 135-142 11292391-5 2001 I(NaCa) was measured at 378 degrees C as current sensitive to external nickel (Ni(2+), 10 mM) during an applied descending voltage ramp. Nickel 71-77 nascent polypeptide-associated complex subunit alpha Cavia porcellus 2-6 11278346-7 2001 Therefore, the ZmHMG I/Y2 protein could prevent nickel toxicity by interfering with chromatin structure. Nickel 48-54 HMG-Y-related protein A Zea mays 15-25 11278346-8 2001 Yeast cell growth in the presence of nickel and yeast cells expressing the ZmHMG I/Y2 cDNA increased telomeric URA3 gene silencing. Nickel 37-43 orotidine-5'-phosphate decarboxylase Saccharomyces cerevisiae S288C 111-115 11278346-9 2001 Furthermore, ZmHMG I/Y2 restored a wild-type level of nickel sensitivity to the yeast (Delta)rpd3 mutant. Nickel 54-60 HMG-Y-related protein A Zea mays 13-23 11278346-10 2001 Therefore, nickel resistance of yeast cells expressing the ZmHMG I/Y2 cDNA is likely achieved by chromatin structure modification, restricting nickel accessibility to DNA. Nickel 11-17 HMG-Y-related protein A Zea mays 59-69 11278346-10 2001 Therefore, nickel resistance of yeast cells expressing the ZmHMG I/Y2 cDNA is likely achieved by chromatin structure modification, restricting nickel accessibility to DNA. Nickel 143-149 HMG-Y-related protein A Zea mays 59-69 11336840-6 2001 HypB is responsible for nickel atom delivery in a GTP-hydrolysis-dependent reaction. Nickel 24-30 SET domain containing 2, histone lysine methyltransferase Homo sapiens 0-4 11372684-4 2001 However, nickel, cobalt, copper, cadmium, and zinc greatly increased HPRG association with the cells. Nickel 9-15 histidine rich glycoprotein Homo sapiens 69-73 11300901-3 2001 The diastereoselectivity (syn/anti ratio) of the process was 86:14, attained with Raney nickel. Nickel 88-94 synemin Homo sapiens 26-29 11396709-7 2001 This is achieved by decreasing the intrathyroidal inorganic iodine concentration by down regulation of the sodium iodine symporter (NIS) and therefore permits the TPO-H202 system to resume normal activity. Nickel 132-135 thyroid peroxidase Homo sapiens 163-166 11261897-1 2001 The purpose of this investigation was to study the effectiveness of two nickel-binding amino acids, histidine (His) and cysteine (Cys), to prevent the inhibitory action of Ni2+ on testosterone (T) production by mouse primary Leydig cell culture. Nickel 72-78 vacuole membrane protein 1 Mus musculus 172-175 11261897-4 2001 In a concentration-response study, Ni2+ (62.5 to 1,000 microM) was added to the cells simultaneously with equimolar or twice the equimolar concentrations of His or Cys and the cultures were maintained for 48 h. Nickel-induced reduction in T production was completely prevented by equimolar concentrations of His at Ni2+ concentrations of 125, 250, and 500 microM; equimolar or twice the equimolar concentrations of His were only partially effective at 1,000 microM Ni2+. Nickel 211-217 vacuole membrane protein 1 Mus musculus 35-38 11308019-6 2001 Protein purified by adsorption to and elution from nickel beads converted Man alpha1-6(Man alpha1-3)Man beta-octyl (M3-octyl) to Man alpha1-6(GlcNAc beta1-2Man alpha1-3)Man beta-octyl. Nickel 51-57 adrenoceptor alpha 1D Homo sapiens 91-99 11260237-8 2001 In the multiple regression analysis, the risk factors for nickel allergy were female sex (OR 8.1, p<0.01), current metal exposure at examination (OR 4.1, p<0.01) and skin piercing (OR 3.6, p<0.05). Nickel 58-64 olfactory receptor family 7 subfamily E member 22 pseudogene Homo sapiens 187-193 11333182-2 2001 We previously demonstrated that nickel can activate an intracellular pathway leading to cytoskeleton reorganization consequent to tyrosine phosphorylation of p60(src) in human platelets independently of integrin alpha-IIb-beta(3). Nickel 32-38 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 158-166 11333182-4 2001 In our study, 1 and 5 mM nickel in the presence of fibrinogen induced platelet aggregation (independently of protein kinase C activation) and secretion. Nickel 25-31 fibrinogen beta chain Homo sapiens 51-61 11512882-7 2001 The nickel first coordination shell in the catalysts containing tungsten is similar to that encountered in COP 1 catalyst without tungsten. Nickel 4-10 COP1 E3 ubiquitin ligase Homo sapiens 107-112 11250053-0 2001 Nickel-induced proteins in human HaCaT keratinocytes: annexin II and phosphoglycerate kinase. Nickel 0-6 annexin A2 Homo sapiens 54-64 11308019-6 2001 Protein purified by adsorption to and elution from nickel beads converted Man alpha1-6(Man alpha1-3)Man beta-octyl (M3-octyl) to Man alpha1-6(GlcNAc beta1-2Man alpha1-3)Man beta-octyl. Nickel 51-57 adrenoceptor alpha 1D Homo sapiens 78-86 11182750-2 2001 We have recently reported that large doses of iodide given to rats chronically decrease the sodium/iodide symporter (NIS) mRNA and protein, suggesting that escape is due to a decrease in NIS and subsequent iodide transport. Nickel 117-120 solute carrier family 5 member 5 Rattus norvegicus 92-115 11308019-6 2001 Protein purified by adsorption to and elution from nickel beads converted Man alpha1-6(Man alpha1-3)Man beta-octyl (M3-octyl) to Man alpha1-6(GlcNAc beta1-2Man alpha1-3)Man beta-octyl. Nickel 51-57 adrenoceptor alpha 1D Homo sapiens 133-141 11308019-6 2001 Protein purified by adsorption to and elution from nickel beads converted Man alpha1-6(Man alpha1-3)Man beta-octyl (M3-octyl) to Man alpha1-6(GlcNAc beta1-2Man alpha1-3)Man beta-octyl. Nickel 51-57 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 149-156 11308019-6 2001 Protein purified by adsorption to and elution from nickel beads converted Man alpha1-6(Man alpha1-3)Man beta-octyl (M3-octyl) to Man alpha1-6(GlcNAc beta1-2Man alpha1-3)Man beta-octyl. Nickel 51-57 adrenoceptor alpha 1D Homo sapiens 160-168 11314867-0 2001 Presence of potential nickel-responsive element(s) in the mouse MTH1 promoter. Nickel 22-28 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus 64-68 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 C-X-C motif chemokine receptor 4 Homo sapiens 25-43 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 CD4 molecule Homo sapiens 136-139 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interleukin 10 Homo sapiens 155-160 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interleukin 10 Homo sapiens 188-193 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interferon gamma Homo sapiens 199-208 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interleukin 4 Homo sapiens 227-231 11145678-2 2001 These cells inhibit in a IL-10-dependent manner the capacity of dendritic cells to activate nickel-specific Tc1 and Th1 lymphocytes. Nickel 92-98 interleukin 10 Homo sapiens 25-30 11145678-2 2001 These cells inhibit in a IL-10-dependent manner the capacity of dendritic cells to activate nickel-specific Tc1 and Th1 lymphocytes. Nickel 92-98 transcriptional and immune response regulator Homo sapiens 108-111 11145678-2 2001 These cells inhibit in a IL-10-dependent manner the capacity of dendritic cells to activate nickel-specific Tc1 and Th1 lymphocytes. Nickel 92-98 negative elongation factor complex member C/D Homo sapiens 116-119 11314867-5 2001 Nickel concentration-dependent increase of CAT protein level was observed for low Ni(II) concentrations, up to 400 microM Ni(II), in cells transfected with pHI103 plasmid (-5969 to +530 of the MTH1 sequence) only. Nickel 0-6 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus 193-197 11314867-10 2001 The results suggest that up-regulation of murine MTH1 expression by nickel(II) is controlled by the repeat sequences, potential candidates for nickel-responsive elements. Nickel 68-74 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus 49-53 11233209-1 2000 Conventional and rapid scan stopped-flow spectrophotometry as well as polarimetry was used to study the kinetics of ligand substitution in six chiral bis N-alkylsalicylaldiminato nickel(II) complexes NiA2 by different chiral salen-type ligands H2B, according to NiA2 + H2B --> NiB + 2HA, in acetone at 298 K and, partly, at variable temperature. Nickel 179-185 H2B clustered histone 21 Homo sapiens 244-247 11762690-4 2001 The simultaneous administration of ascorbic acid with nickel sulfate resulted in a remarkable improvement of lipid peroxide, glutathione, SOD, CAT, and GSH-Px status in liver in comparison with rats treated with nickel alone. Nickel 54-60 catalase Rattus norvegicus 143-146 11137035-3 2001 For example, whereas follicular thyroglobulin suppresses the gene expression and activity of the sodium iodide symporter (NIS), it increases pendrin gene expression. Nickel 122-125 thyroglobulin Homo sapiens 32-45 11272095-1 2001 Decrease or loss of the sodium iodide (Na+/I-) symporter (NIS) activity influences the suitability of using radioiodine to detect and treat metastatic thyroid tissues. Nickel 58-61 solute carrier family 5 member 5 Homo sapiens 39-56 11095610-2 2000 METHODS: A cDNA for MYOC was inserted into a bacterial expression system and purified with nickel ion affinity chromatography. Nickel 91-97 myocilin Homo sapiens 20-24 11464455-9 2000 In SBMA, NIs containing AR protein have been observed in regions of SBMA central nervous system susceptible to degenerations. Nickel 9-12 androgen receptor Mus musculus 24-26 11154568-0 2000 Synthesis, structure, and magnetic properties of the low-symmetry tetranuclear cubane-like nickel complex [Ni4(pypentO)(pym)(mu 3-OH)2(mu- Oac)2(NCS)2(OH2)]. Nickel 91-97 cytosolic thiouridylase subunit 2 Homo sapiens 139-150 11233209-1 2000 Conventional and rapid scan stopped-flow spectrophotometry as well as polarimetry was used to study the kinetics of ligand substitution in six chiral bis N-alkylsalicylaldiminato nickel(II) complexes NiA2 by different chiral salen-type ligands H2B, according to NiA2 + H2B --> NiB + 2HA, in acetone at 298 K and, partly, at variable temperature. Nickel 179-185 H2B clustered histone 21 Homo sapiens 269-272 10938270-7 2000 Importantly, the inhibition of vWF secretion was rescued by depleting the cell extracts of the His-Rab4S22N with nickel beads. Nickel 113-119 von Willebrand factor Homo sapiens 31-34 11073240-0 2000 Nickel-catalyzed Oxabenzonorbornadienes 1 and 2 and azabenzonorbornadiene 3 undergo [2+2] cycloaddition with alkynes (PhC triple bond Ph, PhC triple bond CMe, PhC triple bond CCO2Et, PhC triple bond CCH(OEt)2, and HC triple bond C(CH2)4Me) in the presence of [Ni(PPh3)2Cl2], PPh3, and Zn powder in toluene to afford the corresponding exo-cyclobutene derivatives 4a-e, 5a-e, and 6 in fair to excellent yields. Nickel 0-6 protein phosphatase 4 catalytic subunit Homo sapiens 263-267 11073240-0 2000 Nickel-catalyzed Oxabenzonorbornadienes 1 and 2 and azabenzonorbornadiene 3 undergo [2+2] cycloaddition with alkynes (PhC triple bond Ph, PhC triple bond CMe, PhC triple bond CCO2Et, PhC triple bond CCH(OEt)2, and HC triple bond C(CH2)4Me) in the presence of [Ni(PPh3)2Cl2], PPh3, and Zn powder in toluene to afford the corresponding exo-cyclobutene derivatives 4a-e, 5a-e, and 6 in fair to excellent yields. Nickel 0-6 protein phosphatase 4 catalytic subunit Homo sapiens 275-279 11001757-3 2000 In the present studies, we demonstrate via Western blotting techniques that prolactin elevates the quantity of the sodium iodide symporter (NIS) in cultured mouse mammary tissues. Nickel 140-143 prolactin Mus musculus 76-85 11001757-4 2000 In time-course studies, the onset of the PRL effect of NIS accumulation was found to be between 4 and 16 h after addition of PRL to the explants. Nickel 55-58 prolactin Mus musculus 41-44 11001757-4 2000 In time-course studies, the onset of the PRL effect of NIS accumulation was found to be between 4 and 16 h after addition of PRL to the explants. Nickel 55-58 prolactin Mus musculus 125-128 11001757-6 2000 Actinomycin D, cycloheximide, and thiocyanate abolished the PRL effect on NIS accumulation, whereas perchlorate was without effect. Nickel 74-77 prolactin Mus musculus 60-63 11001757-7 2000 These studies suggest that the PRL stimulation of iodide accumulation in milk is mediated, at least in part, by the PRL stimulation of NIS accumulation in mammary gland tissues. Nickel 135-138 prolactin Mus musculus 31-34 11001757-7 2000 These studies suggest that the PRL stimulation of iodide accumulation in milk is mediated, at least in part, by the PRL stimulation of NIS accumulation in mammary gland tissues. Nickel 135-138 prolactin Mus musculus 116-119 11001757-8 2000 These studies further demonstrate that the PRL effect on NIS accumulation occurs via an RNA protein synthesis-dependent mechanism. Nickel 57-60 prolactin Mus musculus 43-46 11060490-9 2000 In the in situ hybridization study, TNF-beta was found to be the only one of the studied cytokines that differed between the nickel-allergic and control subjects, this difference being most evident at 72 h (p<0.01). Nickel 125-131 lymphotoxin alpha Homo sapiens 36-44 11000099-8 2000 Despite partial recovery of uPA protein levels, uPA activity remained depressed for more than 48 h after exposure to nickel due to the continued increase in PAI-1 expression. Nickel 117-123 plasminogen activator, urokinase Homo sapiens 48-51 11000099-8 2000 Despite partial recovery of uPA protein levels, uPA activity remained depressed for more than 48 h after exposure to nickel due to the continued increase in PAI-1 expression. Nickel 117-123 serpin family E member 1 Homo sapiens 157-162 11000099-10 2000 Sustained loss of uPA activity may contribute to nickel-induced pulmonary fibrosis in exposed populations. Nickel 49-55 plasminogen activator, urokinase Homo sapiens 18-21 10975816-0 2000 Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes. Nickel 32-38 CD8a molecule Homo sapiens 48-51 10975816-3 2000 Skin- and blood-derived nickel-specific CD8+ T cytotoxic 1 (Tc1) and Tc2 clones as well as CD4+ Th1 and Th2 expressed the cutaneous lymphocyte-associated Ag and exhibited strong MHC-restricted cytotoxicity against nickel-coupled B lymphoblasts, as detected by the [3H]TdR release assay. Nickel 24-30 CD8a molecule Homo sapiens 40-43 10975816-3 2000 Skin- and blood-derived nickel-specific CD8+ T cytotoxic 1 (Tc1) and Tc2 clones as well as CD4+ Th1 and Th2 expressed the cutaneous lymphocyte-associated Ag and exhibited strong MHC-restricted cytotoxicity against nickel-coupled B lymphoblasts, as detected by the [3H]TdR release assay. Nickel 24-30 transcobalamin 2 Homo sapiens 69-72 10975816-3 2000 Skin- and blood-derived nickel-specific CD8+ T cytotoxic 1 (Tc1) and Tc2 clones as well as CD4+ Th1 and Th2 expressed the cutaneous lymphocyte-associated Ag and exhibited strong MHC-restricted cytotoxicity against nickel-coupled B lymphoblasts, as detected by the [3H]TdR release assay. Nickel 214-220 CD8a molecule Homo sapiens 40-43 10975816-4 2000 Both Tc1 and Tc2 clones, but not CD4+ T cells, displayed a significant cytotoxic activity against resting nickel-modified keratinocytes. Nickel 106-112 transcobalamin 2 Homo sapiens 13-16 11060490-10 2000 CONCLUSIONS: Our results indicate a difference between nickel-allergic and non-allergic subjects in the synthesis of DNA and production of cytokines when PBMC are stimulated by nickel sulphate, and IL-2 may be regarded as a critical and early-occurring cytokine. Nickel 55-61 interleukin 2 Homo sapiens 198-202 10930330-1 2000 In this study, a supersonic beam of NiF was produced by the reaction of SF(6) with a dc discharge-sputtering source of nickel atoms. Nickel 119-125 S100 calcium binding protein A9 Homo sapiens 36-39 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 CD4 molecule Homo sapiens 16-19 10801856-2 2000 We have solubilized and purified the histidine-tagged yeast secretory pathway/Golgi ion pump Pmr1 to near homogeneity in one step, using nickel affinity chromatography. Nickel 137-143 Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C 93-97 10894741-4 2000 The fre gene was cloned, and the overexpressed protein, with a histidine tag at its N terminus, was purified to homogeneity by nickel affinity chromatography. Nickel 127-133 NAD(P)H-flavin reductase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 4-7 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 interferon gamma Homo sapiens 78-87 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 interleukin 4 Homo sapiens 92-96 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 C-X-C motif chemokine receptor 3 Homo sapiens 138-143 10903743-6 2000 Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone. Nickel 120-126 C-X-C motif chemokine receptor 3 Homo sapiens 9-14 10903743-6 2000 Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone. Nickel 120-126 CD4 molecule Homo sapiens 136-139 10833400-8 2000 The plant-produced GM-CSF was biologically active and could be bound to a nickel affinity matrix, indicating that both the receptor-binding region and the 6-His tag were functional. Nickel 74-80 colony stimulating factor 2 Homo sapiens 19-25 10898577-5 2000 The antibody-spider-nickel bead conjugates were used in magnetic bead depletions of targeted CD8+ lymphocytes or red blood cells (rbcs) in whole blood of normal donors. Nickel 20-26 CD8a molecule Homo sapiens 93-96 10929769-5 2000 The analysis showed that the synthesis of IL-4 and IL-5 but not of IFN-gamma or TNF-alpha was significantly higher in the nickel-allergic individuals. Nickel 122-128 interleukin 4 Homo sapiens 42-46 10929769-5 2000 The analysis showed that the synthesis of IL-4 and IL-5 but not of IFN-gamma or TNF-alpha was significantly higher in the nickel-allergic individuals. Nickel 122-128 interleukin 5 Homo sapiens 51-55 10929769-6 2000 The finding of preferential synthesis of Th2 cytokines was somewhat of a surprise, since previous studies have suggested a Th1 response in nickel-mediated allergic contact dermatitis. Nickel 139-145 negative elongation factor complex member C/D Homo sapiens 123-126 10929769-11 2000 Our results indicate the possibility that IL-4 and IL-5 are involved in the pathogenesis of nickel-mediated contact dermatitis. Nickel 92-98 interleukin 4 Homo sapiens 42-46 10929769-11 2000 Our results indicate the possibility that IL-4 and IL-5 are involved in the pathogenesis of nickel-mediated contact dermatitis. Nickel 92-98 interleukin 5 Homo sapiens 51-55 10880021-8 2000 The bispecific scFv could be purified and concentrated after binding of its 6His tag to a nickel column without significant loss of activity. Nickel 90-96 immunglobulin heavy chain variable region Homo sapiens 15-19 10780946-12 2000 The potassium channel activator diazoxide and the nonspecific calcium channel blockers nickel and cadmium inhibited acute leptin secretion. Nickel 87-93 leptin Homo sapiens 122-128 11254279-8 2000 The factor 1.79 agrees nicely with the stoichiometric ratio, whereas the factor 2.4 implies the accumulation of some nickel in the residual particles. Nickel 117-123 transcription termination factor 2 Homo sapiens 73-81 10802029-9 2000 The increase in GFAP-IR produced by exposure to acidic medium was blocked by pretreatment with nickel ions, by such blockers of L-type calcium channels as nifedipine, verapamil and diltiazem, by calpain inhibitor I, or by the intracellular calcium chelator, BAPTA-AM. Nickel 95-101 glial fibrillary acidic protein Homo sapiens 16-20 10751333-7 2000 In addition, we analyzed the effects of nickel and cobalt on the expression of VEGF in osteoblastic cells because these metallic ions mimic hypoxia by binding to the heme portion of oxygen-sensing molecules. Nickel 40-46 vascular endothelial growth factor A Homo sapiens 79-83 10762681-4 2000 RESULTS: Over a 24- or 72-h exposure time, the nickel-based alloys released a total ion concentration in the parts per billion range and caused alterations in DNA, RNA, and protein synthesis, intracellular ATP levels, and glucose-6-phosphate dehydrogenase activity. Nickel 47-53 glucose-6-phosphate dehydrogenase Homo sapiens 222-255 10751333-9 2000 In addition, we found that nickel and cobalt both stimulate VEGF gene expression in a similar time- and dose-dependent manner, suggesting the presence of a hemelike oxygen-sensing mechanism similar to that of the EPO gene. Nickel 27-33 vascular endothelial growth factor A Homo sapiens 60-64 10751333-11 2000 These studies demonstrate that hypoxia, nickel, and cobalt regulate VEGF expression in osteoblasts via a similar mechanism, implicating the involvement of a heme-containing oxygen-sensing molecule. Nickel 40-46 vascular endothelial growth factor A Homo sapiens 68-72 10835293-9 2000 Taken together, our data suggest that nickel causes a significant increase in the levels of (i) cGMP and c-NOS in adrenals and brain and (ii) i-NOS in pancreas. Nickel 38-44 nitric oxide synthase 3 Rattus norvegicus 105-110 10835293-9 2000 Taken together, our data suggest that nickel causes a significant increase in the levels of (i) cGMP and c-NOS in adrenals and brain and (ii) i-NOS in pancreas. Nickel 38-44 nitric oxide synthase 2 Rattus norvegicus 142-147 10686147-1 2000 The membrane-bound human 3beta-hydroxysteroid dehydrogenase type 1 (3beta-HSD1) was overexpressed with His(6)-tag, using a baculovirus expression system, and then purified by nickel-chelated affinity chromatography. Nickel 175-181 RNA, U1 small nuclear 1 Homo sapiens 25-78 10679259-1 2000 The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction. Nickel 42-48 hypoxia inducible factor 1 subunit alpha Homo sapiens 148-153 10679259-1 2000 The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction. Nickel 42-48 erythropoietin Homo sapiens 169-183 10679259-1 2000 The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction. Nickel 42-48 erythropoietin Homo sapiens 185-188 10684606-5 2000 Then, CO is condensed with a methyl group and coenzyme A at cluster A, another nickel iron-sulfur cluster in the ACS subunit. Nickel 79-85 acyl-CoA synthetase short chain family member 2 Homo sapiens 113-116 10651989-0 2000 Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. Nickel 85-91 CD4 molecule Homo sapiens 6-9 10651989-0 2000 Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. Nickel 85-91 negative elongation factor complex member C/D Homo sapiens 101-104 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 CD4 molecule Homo sapiens 64-67 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interleukin 10 Homo sapiens 110-115 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interleukin 5 Homo sapiens 118-122 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interferon gamma Homo sapiens 125-134 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interleukin 4 Homo sapiens 139-143 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 taste 1 receptor member 1 Homo sapiens 173-176 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 238-244 CD4 molecule Homo sapiens 64-67 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 238-244 taste 1 receptor member 1 Homo sapiens 173-176 10651989-4 2000 Tr1 clones were isolated from skin challenged with NiSO4 and peripheral blood of nickel-allergic patients, and from the blood of healthy individuals. Nickel 81-87 taste 1 receptor member 1 Homo sapiens 0-3 10651989-6 2000 Monocytes precultured with Tr1 cells in the presence of nickel, or treated with Tr1-derived supernatant, exhibited a markedly diminished capacity to stimulate nickel-specific Th1 responses. Nickel 56-62 taste 1 receptor member 1 Homo sapiens 27-30 10651989-6 2000 Monocytes precultured with Tr1 cells in the presence of nickel, or treated with Tr1-derived supernatant, exhibited a markedly diminished capacity to stimulate nickel-specific Th1 responses. Nickel 56-62 negative elongation factor complex member C/D Homo sapiens 175-178 10651989-6 2000 Monocytes precultured with Tr1 cells in the presence of nickel, or treated with Tr1-derived supernatant, exhibited a markedly diminished capacity to stimulate nickel-specific Th1 responses. Nickel 159-165 taste 1 receptor member 1 Homo sapiens 27-30 10651989-6 2000 Monocytes precultured with Tr1 cells in the presence of nickel, or treated with Tr1-derived supernatant, exhibited a markedly diminished capacity to stimulate nickel-specific Th1 responses. Nickel 159-165 taste 1 receptor member 1 Homo sapiens 80-83 10651989-6 2000 Monocytes precultured with Tr1 cells in the presence of nickel, or treated with Tr1-derived supernatant, exhibited a markedly diminished capacity to stimulate nickel-specific Th1 responses. Nickel 159-165 negative elongation factor complex member C/D Homo sapiens 175-178 10651989-8 2000 As a consequence, the ability of DC to stimulate nickel-specific Th1 and Tc1 responses was greatly impaired. Nickel 49-55 negative elongation factor complex member C/D Homo sapiens 65-68 10651989-8 2000 As a consequence, the ability of DC to stimulate nickel-specific Th1 and Tc1 responses was greatly impaired. Nickel 49-55 transcriptional and immune response regulator Homo sapiens 73-76 10667566-7 2000 Nickel was also found to inhibit the acetylation of H4 in vitro using purified recombinant histone acetyltransferase. Nickel 0-6 histone acetyltransferase Saccharomyces cerevisiae S288C 91-116 10634928-5 2000 External Ca(2+) chelation (EGTA 4 mM) or administration of Ca(2+) channel inhibitors gadolinium 50 microM or nickel 500 microM inhibited insulin-induced PI 3-kinase activation by 85, 50 and 50%, respectively, whereas 200 microM verapamil was without effect. Nickel 109-115 WAP four-disulfide core domain 15B Rattus norvegicus 153-157 10681048-0 2000 Purification of the membrane binding domain of cytochrome b5 by immobilised nickel chelate chromatography. Nickel 76-82 cytochrome b5 type A Bos taurus 47-60 10646848-2 2000 Here we have demonstrated that nickel exposure induced hypoxic signaling pathways by inducing hypoxia-inducible transcription factor-1 (HIF-1), which mediated the induction of genes required by cells to survive hypoxia. Nickel 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-134 10646848-2 2000 Here we have demonstrated that nickel exposure induced hypoxic signaling pathways by inducing hypoxia-inducible transcription factor-1 (HIF-1), which mediated the induction of genes required by cells to survive hypoxia. Nickel 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-141 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 N-myc downstream regulated 1 Homo sapiens 30-35 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-60 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 hypoxia inducible factor 1 subunit alpha Homo sapiens 74-79 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 N-myc downstream regulated 1 Homo sapiens 105-110 10646848-4 2000 We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. Nickel 189-195 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 18-58 10646848-4 2000 We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. Nickel 189-195 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-99 10646848-4 2000 We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. Nickel 189-195 N-myc downstream regulated 1 Homo sapiens 116-121 10646848-4 2000 We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. Nickel 189-195 hypoxia inducible factor 1 subunit alpha Homo sapiens 142-147 10644023-5 2000 After iontophoresis with nickel sulfate, only individuals sensitized to nickel reacted with a positive clinical response, increase in cutaneous blood flow, decline in epidermal CD-1a-positive cells, increase in epidermal proliferation (Ki-67-positive cells), pronounced infiltration of cells positive for CD4, CD11, or CLA, and cellular activation (expression of ICAM1, HLA-DR). Nickel 25-31 CD1a molecule Homo sapiens 177-182 10644023-5 2000 After iontophoresis with nickel sulfate, only individuals sensitized to nickel reacted with a positive clinical response, increase in cutaneous blood flow, decline in epidermal CD-1a-positive cells, increase in epidermal proliferation (Ki-67-positive cells), pronounced infiltration of cells positive for CD4, CD11, or CLA, and cellular activation (expression of ICAM1, HLA-DR). Nickel 25-31 CD4 molecule Homo sapiens 305-308 10644023-5 2000 After iontophoresis with nickel sulfate, only individuals sensitized to nickel reacted with a positive clinical response, increase in cutaneous blood flow, decline in epidermal CD-1a-positive cells, increase in epidermal proliferation (Ki-67-positive cells), pronounced infiltration of cells positive for CD4, CD11, or CLA, and cellular activation (expression of ICAM1, HLA-DR). Nickel 25-31 selectin P ligand Homo sapiens 319-322 10644023-5 2000 After iontophoresis with nickel sulfate, only individuals sensitized to nickel reacted with a positive clinical response, increase in cutaneous blood flow, decline in epidermal CD-1a-positive cells, increase in epidermal proliferation (Ki-67-positive cells), pronounced infiltration of cells positive for CD4, CD11, or CLA, and cellular activation (expression of ICAM1, HLA-DR). Nickel 25-31 intercellular adhesion molecule 1 Homo sapiens 363-368 10665818-7 2000 But, the presence of nickel (50 microM), an antagonist of low-voltage-activated Ca2+ channel, inhibited the taurine-induced potentiation, indicating that Ca2+ influx through this type of Ca2+ channels could account for the Ca2+ requirement of the taurine-induced potentiation. Nickel 21-27 carbonic anhydrase 2 Rattus norvegicus 80-83 22607421-6 2000 Nickel and cobalt ions inhibited binding of p53 to scDNA and to p53CON in linear DNA fragments less efficiently than zinc. Nickel 0-6 tumor protein p53 Homo sapiens 44-47 22607421-6 2000 Nickel and cobalt ions inhibited binding of p53 to scDNA and to p53CON in linear DNA fragments less efficiently than zinc. Nickel 0-6 tumor protein p53 Homo sapiens 64-67 11030089-0 2000 Nickel-induced substrate inhibition of bovine liver glutamate dehydrogenase. Nickel 0-6 glutamate dehydrogenase 1, mitochondrial Bos taurus 52-75 11030089-1 2000 The effects of nickel ions on reductive amination and oxidative deamination activities of bovine liver glutamate dehydrogenase (GDH) were examined kinetically by UV spectroscopy, at 27 degrees C, using 50 mM Tris, pH 7.8, containing 0.1 M NaCl. Nickel 15-21 glutamate dehydrogenase 1, mitochondrial Bos taurus 103-126 11030089-1 2000 The effects of nickel ions on reductive amination and oxidative deamination activities of bovine liver glutamate dehydrogenase (GDH) were examined kinetically by UV spectroscopy, at 27 degrees C, using 50 mM Tris, pH 7.8, containing 0.1 M NaCl. Nickel 15-21 glutamate dehydrogenase 1, mitochondrial Bos taurus 128-131 11030089-8 2000 These observations are explained in terms of formation of a nickel-NADH complex with a higher affinity for binding to the regulatory site in GDH, as compared with the situation where nickel is not present. Nickel 60-66 glutamate dehydrogenase 1, mitochondrial Bos taurus 141-144 11030089-8 2000 These observations are explained in terms of formation of a nickel-NADH complex with a higher affinity for binding to the regulatory site in GDH, as compared with the situation where nickel is not present. Nickel 183-189 glutamate dehydrogenase 1, mitochondrial Bos taurus 141-144 10630443-8 2000 METHODS: Recombinant Tir, Tir-N, Tir-M, and Tir-C were expressed as His-tagged protein in E. coli BL21a and purified on nickel columns. Nickel 120-126 Tir Escherichia coli 21-24 10665818-7 2000 But, the presence of nickel (50 microM), an antagonist of low-voltage-activated Ca2+ channel, inhibited the taurine-induced potentiation, indicating that Ca2+ influx through this type of Ca2+ channels could account for the Ca2+ requirement of the taurine-induced potentiation. Nickel 21-27 carbonic anhydrase 2 Rattus norvegicus 154-157 10665818-7 2000 But, the presence of nickel (50 microM), an antagonist of low-voltage-activated Ca2+ channel, inhibited the taurine-induced potentiation, indicating that Ca2+ influx through this type of Ca2+ channels could account for the Ca2+ requirement of the taurine-induced potentiation. Nickel 21-27 carbonic anhydrase 2 Rattus norvegicus 154-157 10665818-7 2000 But, the presence of nickel (50 microM), an antagonist of low-voltage-activated Ca2+ channel, inhibited the taurine-induced potentiation, indicating that Ca2+ influx through this type of Ca2+ channels could account for the Ca2+ requirement of the taurine-induced potentiation. Nickel 21-27 carbonic anhydrase 2 Rattus norvegicus 154-157 10640674-9 1999 Together, these data confirm the presence of NIs in brain and retina of a SCA7 patient, a common characteristic of disorders caused by expanded CAG/polyGln repeats. Nickel 45-48 ataxin 7 Homo sapiens 74-78 10593920-6 1999 Detergent-solubilized FATP1-Myc/His was partially purified using nickel-based affinity chromatography and demonstrated a 10-fold increase in very long chain acyl-CoA specific activity (C24:0/C16:0). Nickel 65-71 solute carrier family 27 member 1 Homo sapiens 22-27 11529188-11 1999 The arithmetic mean value +/- s of nickel was 0.64 +/- 0.56 microgram g-1 and 0.29 +/- 0.20 microgram g-1 dry weight, respectively, for samples collected with a regular scalpel and a titanium knife (P < 0.0001). Nickel 35-41 proline rich protein BstNI subfamily 3 Homo sapiens 70-82 11529189-4 1999 The mean observed urinary nickel concentration was 12 micrograms L-1 (11 micrograms of Ni per g of creatinine). Nickel 26-32 immunoglobulin kappa variable 1-16 Homo sapiens 65-68 11671276-1 1999 To examine the porphyrin-core expansion and the conformational variations induced by a change in the coordination sphere of nickel(II) from four-coordinate, low-spin (S = 0) to six-coordinate, high-spin (S = 1), several nickel(II) derivatives of tetraphenylporphyrins, substituted in their beta-pyrrole positions with electron-withdrawing groups, were isolated and studied by X-ray crystallography. Nickel 124-130 spindlin 1 Homo sapiens 161-165 11671276-1 1999 To examine the porphyrin-core expansion and the conformational variations induced by a change in the coordination sphere of nickel(II) from four-coordinate, low-spin (S = 0) to six-coordinate, high-spin (S = 1), several nickel(II) derivatives of tetraphenylporphyrins, substituted in their beta-pyrrole positions with electron-withdrawing groups, were isolated and studied by X-ray crystallography. Nickel 124-130 spindlin 1 Homo sapiens 198-202 11671276-4 1999 This study confirms that, upon conversion of a four-coordinate, low-spin nickel(II) derivative of a beta-pyrrole-substituted tetraphenylporphyrin into a six-coordinate, high-spin complex, a radial expansion of the porphyrin core also takes place. Nickel 73-79 spindlin 1 Homo sapiens 68-72 11671276-4 1999 This study confirms that, upon conversion of a four-coordinate, low-spin nickel(II) derivative of a beta-pyrrole-substituted tetraphenylporphyrin into a six-coordinate, high-spin complex, a radial expansion of the porphyrin core also takes place. Nickel 73-79 spindlin 1 Homo sapiens 174-178 10602394-3 1999 Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)]. Nickel 18-24 hematopoietic prostaglandin D synthase Rattus norvegicus 190-215 11212309-2 1999 The seven known nickel enzymes are urease, hydrogenase, CO-dehydrogenase, methyl-coenzyme M reductase, Ni-superoxide dismutase, glyoxalase I and cis-trans isomerase. Nickel 16-22 glyoxalase I Homo sapiens 128-140 10602394-3 1999 Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)]. Nickel 18-24 hematopoietic prostaglandin D synthase Rattus norvegicus 217-220 10602394-3 1999 Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)]. Nickel 18-24 glutathione-disulfide reductase Rattus norvegicus 226-247 10602394-3 1999 Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)]. Nickel 18-24 glutathione-disulfide reductase Rattus norvegicus 249-251 10527911-0 1999 Role of Ca(2+) in the regulation of nickel-inducible Cap43 gene expression. Nickel 36-42 N-myc downstream regulated 1 Homo sapiens 53-58 10497068-5 1999 We have successfully expressed and purified both wild-type and mutant recombinant mouse fibrillarin using nickel-chelation chromatography. Nickel 106-112 fibrillarin Mus musculus 88-99 10515200-4 1999 The recombinant MMP-20 was purified using Mono-S ion exchange and nickel affinity chromatography. Nickel 66-72 matrix metallopeptidase 20 Bos taurus 16-22 10469629-0 1999 Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 57-62 10469629-0 1999 Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Nickel 0-6 tumor protein p53 Homo sapiens 67-70 10394941-4 1999 Both IDH4 and IDH1 enzymes were expressed in Escherichia coli as catalytically active His6 tagged proteins, purified to homogeneity by affinity chromatography on nickel chelate resin and rabbit polyclonal antibodies to each were generated. Nickel 162-168 NADP-dependent isocitrate dehydrogenase Glycine max 14-18 10453014-0 1999 TCR reactivity in human nickel allergy indicates contacts with complementarity-determining region 3 but excludes superantigen-like recognition. Nickel 24-30 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-3 10453014-12 1999 These results define specific amino acids in the CDR3B region of a VB17+ TCR to be crucial for human nickel recognition. Nickel 101-107 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 73-76 10433982-4 1999 The nonspecific voltage-sensitive calcium channel (VSCC) antagonists, cadmium (200 nmol/eye) and nickel (100 nmol/eye) reduced the amount of (125)I-anti-DBH retrograde axonal transport by 90 and 70%, respectively. Nickel 97-103 dopamine beta-hydroxylase Homo sapiens 153-156 10357133-10 1999 Nevertheless, cells exposed to nickel were impaired to reach confluency, which was determined by cadherin-5 expression. Nickel 31-37 cadherin 5 Homo sapiens 97-107 10419831-5 1999 The liberated CTAPIII and NAP/2 were separated from (His)(6)-Ub, the trace amounts of unreacted (His)(6)-Ub-CTAPIII, HIV-1 Pr, and the (His)(6)-YUH1 by passage over a nickel-chelate column; the final yield was about 10 mg of peptide/liter of cell culture. Nickel 167-173 pro-platelet basic protein Homo sapiens 14-21 10419831-5 1999 The liberated CTAPIII and NAP/2 were separated from (His)(6)-Ub, the trace amounts of unreacted (His)(6)-Ub-CTAPIII, HIV-1 Pr, and the (His)(6)-YUH1 by passage over a nickel-chelate column; the final yield was about 10 mg of peptide/liter of cell culture. Nickel 167-173 pro-platelet basic protein Homo sapiens 26-31 10380883-9 1999 Nickel and cobalt ions inhibit binding of p53 to scDNA and to its consensus sequence in linear DNA fragments less efficiently than zinc; cobalt ions are least efficient, requiring >100 microM Co2+ for full inhibition of p53 binding. Nickel 0-6 tumor protein p53 Homo sapiens 42-45 10380883-9 1999 Nickel and cobalt ions inhibit binding of p53 to scDNA and to its consensus sequence in linear DNA fragments less efficiently than zinc; cobalt ions are least efficient, requiring >100 microM Co2+ for full inhibition of p53 binding. Nickel 0-6 tumor protein p53 Homo sapiens 223-226 10397983-9 1999 Only pure nickel suppressed (by 48% compared to Teflon controls) the SDH activity of the HMVECs or THP-1 monocytes. Nickel 10-16 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 69-72 10397983-9 1999 Only pure nickel suppressed (by 48% compared to Teflon controls) the SDH activity of the HMVECs or THP-1 monocytes. Nickel 10-16 GLI family zinc finger 2 Homo sapiens 99-104 10231572-7 1999 Expression from the sodF1 gene was repressed by nickel as sensitively as Muller sodF, suggesting the presence of Ni-responsive regulatory site within the region shared by the two genes. Nickel 48-54 SCO2633 Streptomyces coelicolor A3(2) 20-24 10208869-1 1999 Saccharomyces cerevisiae became less sensitive to nickel by a defect of the SPT7 gene encoding a transcription factor. Nickel 50-56 SAGA histone acetyltransferase complex subunit SPT7 Saccharomyces cerevisiae S288C 76-80 10208869-2 1999 Initial rate of nickel uptake by whole cells of a SPT7-negative mutant FY963 was nearly equal to that of the parent strain FY61, and FY963 accumulated nickel about 1.7-fold of the value of FY61 when cultured in medium containing 0.1 mM NiCl2; most of which was sequestered into vacuoles. Nickel 16-22 SAGA histone acetyltransferase complex subunit SPT7 Saccharomyces cerevisiae S288C 50-54 10208869-4 1999 Involvement of Spt7p in nickel detoxification through regulation of vacuolar polyphosphate level in S. cerevisiae was discussed. Nickel 24-30 SAGA histone acetyltransferase complex subunit SPT7 Saccharomyces cerevisiae S288C 15-20 10213617-7 1999 In a mutant P-gp (E875C) that gave about equal amounts of both topologies, only the C-Half (CL3-cyt) could be recovered by nickel chromatography after coexpression with the histidine-tagged N-Half P-gp. Nickel 123-129 ATP binding cassette subfamily B member 1 Homo sapiens 12-16 10213617-7 1999 In a mutant P-gp (E875C) that gave about equal amounts of both topologies, only the C-Half (CL3-cyt) could be recovered by nickel chromatography after coexpression with the histidine-tagged N-Half P-gp. Nickel 123-129 adhesion G protein-coupled receptor L3 Homo sapiens 92-95 10209334-3 1999 Nickel also induced the inactivation of the gpt reporter gene by chromatin condensation and a DNA methylation process in a transgenic gpt+ Chinese hamster cell line (G12), which is located near a heterochromatic region. Nickel 0-6 alanine aminotransferase 1 Cricetulus griseus 44-47 10209334-3 1999 Nickel also induced the inactivation of the gpt reporter gene by chromatin condensation and a DNA methylation process in a transgenic gpt+ Chinese hamster cell line (G12), which is located near a heterochromatic region. Nickel 0-6 alanine aminotransferase 1 Cricetulus griseus 134-137 10199784-9 1999 In the simple enzyme-linked immunosorbent assay, the TSHRE immobilized on the wells coated with nickel showed significantly higher binding with the IgGs from Graves" patients than in those from normal individuals. Nickel 96-102 thyroid stimulating hormone receptor Homo sapiens 53-58 11864456-6 1999 Low levels of the two kinds of metal (0.10 - 0.40 micromol/L of nickel and 0.16 micromol/L of cadmium) could induce the cleavage of DNA and activate PARP, and high levels of the two kinds of metal (2.00 - 10.00 micromol/L of nickel and 0.80 - 20.00 micromol/L of cadmium) could not induce the enzyme cleavage of DNA. Nickel 64-70 poly(ADP-ribose) polymerase 1 Homo sapiens 149-153 9916029-3 1999 Single-headed myosin, which consists of a full length myosin heavy chain and a tagged tail, was isolated on the basis of the affinities for Nickel agarose and actin. Nickel 140-146 myosin heavy chain 14 Homo sapiens 14-20 9988725-5 1999 It was demonstrated that the nickel-dependent N-terminal oxidative deamination also occurred in His-2 peptides using potassium peroxymonosulfate (oxone) as an oxidant. Nickel 29-35 histatin 3 Homo sapiens 96-101 9886425-0 1999 IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. Nickel 21-27 interleukin 17A Homo sapiens 0-5 9880564-13 1999 This CETP inhibitor activity was efficiently removed from the media by nickel-Sepharose, consistent with the 6-His tag incorporated into recombinant apoF. Nickel 71-77 cholesteryl ester transfer protein Homo sapiens 5-9 9880564-13 1999 This CETP inhibitor activity was efficiently removed from the media by nickel-Sepharose, consistent with the 6-His tag incorporated into recombinant apoF. Nickel 71-77 apolipoprotein F Homo sapiens 149-153 9854036-4 1999 Mouse GSTT1-1 was expressed in Escherichia coli as an N-terminal 6x histidine-tagged protein and purified using immobilized-metal affinity chromatography on nickel-agarose. Nickel 157-163 glutathione S-transferase, theta 1 Mus musculus 6-13 9886425-2 1999 In this study, we investigated whether hapten-specific T cells isolated from patients with allergic contact dermatitis (ACD) to nickel produce IL-17 and the effects of IL-17 alone or in combination with IFN-gamma or TNF-alpha on the immune activation of keratinocytes. Nickel 128-134 interleukin 17A Homo sapiens 143-148 9886425-3 1999 Skin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs. Nickel 51-57 interferon gamma Homo sapiens 95-104 9886425-3 1999 Skin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs. Nickel 51-57 tumor necrosis factor Homo sapiens 106-115 9886425-3 1999 Skin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs. Nickel 51-57 interleukin 17A Homo sapiens 121-126 9886425-4 1999 Four of seven nickel-specific CD4+ T cell clones positive for the skin-homing receptor, cutaneous lymphocyte-associated Ag, were shown to corelease IL-17, IFN-gamma, and TNF-alpha. Nickel 14-20 interleukin 17A Homo sapiens 148-153 9886425-4 1999 Four of seven nickel-specific CD4+ T cell clones positive for the skin-homing receptor, cutaneous lymphocyte-associated Ag, were shown to corelease IL-17, IFN-gamma, and TNF-alpha. Nickel 14-20 interferon gamma Homo sapiens 155-164 9886425-4 1999 Four of seven nickel-specific CD4+ T cell clones positive for the skin-homing receptor, cutaneous lymphocyte-associated Ag, were shown to corelease IL-17, IFN-gamma, and TNF-alpha. Nickel 14-20 tumor necrosis factor Homo sapiens 170-179 9874038-0 1998 Nickel in tap water in Warsaw. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 10-13 9804843-8 1998 His6-tagged Tsc10p was expressed in Escherichia coli and isolated by nickel-nitrilotriacetic acid column chromatography. Nickel 69-75 3-dehydrosphinganine reductase Saccharomyces cerevisiae S288C 12-18 9879805-6 1998 While the MGMT protein level was not altered in the presence of nickel(II), the MGMT activity was diminished as demonstrated in cell extracts form nickel-treated cells. Nickel 147-153 O-6-methylguanine-DNA methyltransferase Homo sapiens 80-84 9840261-1 1998 In this study, we investigated the effect of pentoxifylline, an inhibitor of TNF-alpha, on the contact sensitivity response induced by nickel. Nickel 135-141 tumor necrosis factor Cavia porcellus 77-86 9804373-5 1998 ApoE evoked Ca2+-increases are blocked in zero [Ca]o and by the Ca-channel antagonists nickel and omega-Agatoxin-IVa but not by nifedipine and omega-Conotoxin-GVIa, demonstrating an isoform-specific activation of P/Q type Ca2+-channels. Nickel 87-93 apolipoprotein E Rattus norvegicus 0-4 12114713-7 1998 Sequencing of the entire sodium/iodide (Na/I) symporter (NIS) cDNA derived from thyroidal mRNA revealed a homozygous substitution of the normal cytosine in nucleotide 1163 with an adenine, resulting in a stop signal at codon 272. Nickel 57-60 solute carrier family 5 member 5 Homo sapiens 40-55 29710957-0 1998 An Efficient Nickel-Catalyzed Cross-Coupling Between sp3 Carbon Centers. Nickel 13-19 Sp3 transcription factor Homo sapiens 53-56 9840004-8 1998 Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold). Nickel 144-150 interleukin 6 Homo sapiens 10-14 9740224-0 1998 MHC-dependent and -independent activation of human nickel-specific CD8+ cytotoxic T cells from allergic donors. Nickel 51-57 major histocompatibility complex, class I, C Homo sapiens 0-3 9740224-0 1998 MHC-dependent and -independent activation of human nickel-specific CD8+ cytotoxic T cells from allergic donors. Nickel 51-57 CD8a molecule Homo sapiens 67-70 9740224-2 1998 Nickel is the most common contact sensitizer in humans and nickel-specific CD4+ T helper cells have been extensively characterized. Nickel 59-65 CD4 molecule Homo sapiens 75-78 9740224-3 1998 Because recent observations have suggested the activation of CD8+ T cells in murine models of contact hypersensitivity, we investigated the existence of CD8+ hapten-specific T lymphocytes in patients with allergy to nickel. Nickel 216-222 CD8a molecule Homo sapiens 153-156 9740224-9 1998 These CD8+ T cells did not only display hapten-specific proliferation, but also specific cytotoxic activities towards autologous EBV-B cells in the presence of nickel. Nickel 160-166 CD8a molecule Homo sapiens 6-9 9740224-12 1998 The characterization of nickel-specific cytotoxic CD8+ T cells with different requirements for nickel-specific target lysis, may have important implications in the development or in the control of human contact hypersensitivity reactions to nickel in vivo. Nickel 24-30 CD8a molecule Homo sapiens 50-53 9740224-12 1998 The characterization of nickel-specific cytotoxic CD8+ T cells with different requirements for nickel-specific target lysis, may have important implications in the development or in the control of human contact hypersensitivity reactions to nickel in vivo. Nickel 95-101 CD8a molecule Homo sapiens 50-53 9740224-12 1998 The characterization of nickel-specific cytotoxic CD8+ T cells with different requirements for nickel-specific target lysis, may have important implications in the development or in the control of human contact hypersensitivity reactions to nickel in vivo. Nickel 95-101 CD8a molecule Homo sapiens 50-53 9709838-1 1998 Due to their exceptional temperature sensitivity, superelastic nickel titanium wires may be affected by temperature changes associated with ingestion of cold or hot food. Nickel 63-69 alcohol dehydrogenase iron containing 1 Homo sapiens 161-164 9746341-0 1998 The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells. Nickel 17-23 erythropoietin Homo sapiens 88-102 9746341-1 1998 Cobalt and nickel stimulate, as does hypoxia, the production of erythropoietin (EPO) in HepG2 cells. Nickel 11-17 erythropoietin Homo sapiens 64-78 9746341-1 1998 Cobalt and nickel stimulate, as does hypoxia, the production of erythropoietin (EPO) in HepG2 cells. Nickel 11-17 erythropoietin Homo sapiens 80-83 9653173-4 1998 TSH does this by modulating the expression and activity of several thyroid-specific transcription factors, thyroid transcription factor (TTF)-1, TTF-2, and Pax-8, which coordinately regulate NIS, TPO, TG, and the TSHR. Nickel 191-194 transcription termination factor 1 Homo sapiens 107-143 9675033-4 1998 The peptide Leu155-Val260 immobilized by the polyhistidine tag on a nickel chelate column bound TGF-beta1 and -beta2 almost as effectively as the largest fragment (Asp45-Lys359) studied. Nickel 68-74 transforming growth factor beta 1 Homo sapiens 96-116 9653173-4 1998 TSH does this by modulating the expression and activity of several thyroid-specific transcription factors, thyroid transcription factor (TTF)-1, TTF-2, and Pax-8, which coordinately regulate NIS, TPO, TG, and the TSHR. Nickel 191-194 transcription termination factor 2 Homo sapiens 145-150 9653173-4 1998 TSH does this by modulating the expression and activity of several thyroid-specific transcription factors, thyroid transcription factor (TTF)-1, TTF-2, and Pax-8, which coordinately regulate NIS, TPO, TG, and the TSHR. Nickel 191-194 paired box 8 Homo sapiens 156-161 9501525-3 1998 Recombinant calpastatin was purified to homogeneity by nickel ion affinity chromatography and gel filtration separation. Nickel 55-61 calpastatin Homo sapiens 12-23 9683178-14 1998 High concentration of nickel(II) appears to up-regulate protein(s) other than the common form of p53 protein. Nickel 22-28 cellular tumor antigen p53 Cricetulus griseus 97-100 9749974-10 1998 The prevalence of "elevated" NAG (>7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23.5%), then among nickel-chrome workers (7.1%) and aluminum workers (8.7%). Nickel 137-143 O-GlcNAcase Homo sapiens 29-32 9714417-0 1998 Restricted and individual usage of T-cell receptor beta-gene variables in nickel-induced CD4+ and CD8+ cells. Nickel 74-80 CD4 molecule Homo sapiens 89-92 9714417-2 1998 We examined the T-cell receptor (TCR) beta-chain variable gene segment (Vbeta) use of nickel-induced CD4+ and CD8+ T cells in the peripheral blood of nickel-sensitive and nonsensitized subjects. Nickel 86-92 CD4 molecule Homo sapiens 101-104 9714417-7 1998 In conclusion, an individual pattern of restricted Vbeta genes was induced with nickel in CD4+ and CD8+ T cells in each nickel allergy patient. Nickel 80-86 CD4 molecule Homo sapiens 90-93 9714417-7 1998 In conclusion, an individual pattern of restricted Vbeta genes was induced with nickel in CD4+ and CD8+ T cells in each nickel allergy patient. Nickel 120-126 CD4 molecule Homo sapiens 90-93 9924633-7 1998 We conclude that PTH amino acids 73-76 are essential for activation of a nickel-insensitive Ca2+ influx pathway in growth plate chondrocytes that is likely to be of relevance for matrix calcification, a key step in endochondral bone formation. Nickel 73-79 parathyroid hormone Homo sapiens 17-20 9610360-0 1998 Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site. Nickel 125-131 peptide deformylase Escherichia coli 73-92 9605764-8 1998 The Cap43 gene was found to be induced by nickel not only in all tested human and rodent cell lines in vitro but also in several rat organs after oral exposure to NiCl2. Nickel 42-48 N-myc downstream regulated 1 Homo sapiens 4-9 9602219-1 1998 Nickel, the allergen of contact dermatitis, induces the in vitro production of inflammation markers such as intracellular adhesion molecule-1, interleukin-1 and tumour necrosis factor-alpha by keratinocytes. Nickel 0-6 interleukin 1 alpha Homo sapiens 143-189 9666569-3 1998 Differential scanning calorimetry scans of solutions of the metal ion derivatives of Con A show that the thermodynamics of the unfolding transition for the cobalt and nickel substituted derivatives are the same as for Con A: they dissociate from tetramers into monomers as they unfold around 85 degrees C. The cadmium substituted Con A derivative, however, exhibits an additional transition around 93 degrees C which also appears following the addition of Cd2+ to the Con A solutions. Nickel 167-173 CD2 molecule Homo sapiens 456-459 9592734-3 1998 The recombinant E2 protein contained an aminoterminal tag of six histidines that could be used for purification by the nickel chelate affinity chromatography. Nickel 119-125 ubiquitin conjugating enzyme E2 B Homo sapiens 16-26 9507026-9 1998 Of the several transition metals (zinc, cadmium, nickel, silver, copper, and cobalt) examined, only zinc facilitated activation of the DNA binding activity of recombinant MTF-1. Nickel 49-55 metal regulatory transcription factor 1 Homo sapiens 171-176 9486123-3 1998 GAPDH was induced in cells by the transition metals cobalt, nickel, and manganese and by deferoxamine, and GAPDH mRNA induction by hypoxia was blocked by cycloheximide. Nickel 60-66 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 9576593-5 1998 One month after implantation, the mean fluorescence intensity of CD4, CD8 or Smig, in the peripheral blood lymphocytes (PBL) of the nickel alloy-implanted animals, was significantly higher than that prior to this procedure. Nickel 132-138 CD4 antigen Mus musculus 65-68 9536222-3 1998 In proliferative HaCaT cells, following a 24 h exposure, nickel compounds, para-phenylenediamine (pPD) and 1-chloro-2,4-dinitrobenzene produced a concentration-dependent up-regulation of ICAM-1 expression without reducing cell viability, while K2Cr2O7 led to ICAM-1 up-regulation at cytotoxic concentrations, and CrCl3 was without effect. Nickel 57-63 intercellular adhesion molecule 1 Homo sapiens 187-193 9536222-3 1998 In proliferative HaCaT cells, following a 24 h exposure, nickel compounds, para-phenylenediamine (pPD) and 1-chloro-2,4-dinitrobenzene produced a concentration-dependent up-regulation of ICAM-1 expression without reducing cell viability, while K2Cr2O7 led to ICAM-1 up-regulation at cytotoxic concentrations, and CrCl3 was without effect. Nickel 57-63 intercellular adhesion molecule 1 Homo sapiens 259-265 9371503-0 1997 Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression. Nickel 50-56 activating transcription factor 1 Mus musculus 13-46 9371503-7 1997 This Mr 35,000 nuclear ATF-1 protein was shown to be present in higher amounts in nickel-transformed 3T3 cells that do not express TSP 1. Nickel 82-88 activating transcription factor 1 Mus musculus 23-28 9371503-9 1997 These results show that nickel exposure causes accumulation of the ATF-1 transcription factor, which is responsible for the down-regulation of transcription of TSP I, and possibly other tumor suppressor genes during nickel-induced cellular transformation. Nickel 24-30 glial cell line derived neurotrophic factor Mus musculus 67-70 9371503-9 1997 These results show that nickel exposure causes accumulation of the ATF-1 transcription factor, which is responsible for the down-regulation of transcription of TSP I, and possibly other tumor suppressor genes during nickel-induced cellular transformation. Nickel 216-222 glial cell line derived neurotrophic factor Mus musculus 67-70 9404557-1 1997 CD30 expression was evaluated by immunohistochemistry in lesional skin biopsies of eight patients with active atopic dermatitis (AD) and three patients with allergic contact (nickel-induced) dermatitis (ACD). Nickel 175-181 TNF receptor superfamily member 8 Homo sapiens 0-4 9334419-8 1997 This phase-shifting effect of NPY was not altered by block of sodium channels with tetrodotoxin or block of calcium channels with cadmium and nickel, consistent with a direct postsynaptic site of action. Nickel 142-148 neuropeptide Y Homo sapiens 30-33 9389301-6 1997 In contrast, the percentages of CLA+ T cells in the lesional skin of patients with AD, in the APT reactions, and in sodium lauryl sulfate and nickel patch test reactions were decreased. Nickel 142-148 selectin P ligand Homo sapiens 32-35 9390328-7 1997 Hydrocortisone reduced the basal level as well as the nickel-induced upregulation of VEGF. Nickel 54-60 vascular endothelial growth factor A Homo sapiens 85-89 9376342-0 1997 Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 27-47 9376342-0 1997 Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 116-136 9376342-0 1997 Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 116-136 9385511-1 1997 Different T-helper subsets, which are characterized by the secretion of distinct cytokines (Th1, Th2), have been found in house dust mite-exposed skin of sensitized individuals and in nickel-specific T lymphocytes from nickel contact allergic and non-allergic individuals. Nickel 184-190 negative elongation factor complex member C/D Homo sapiens 92-95 9385511-1 1997 Different T-helper subsets, which are characterized by the secretion of distinct cytokines (Th1, Th2), have been found in house dust mite-exposed skin of sensitized individuals and in nickel-specific T lymphocytes from nickel contact allergic and non-allergic individuals. Nickel 219-225 negative elongation factor complex member C/D Homo sapiens 92-95 9299349-3 1997 When the alpha-subunit (alpha-MPP) was co-expressed with N-terminal hexa-histidine tagged beta-MPP, alpha-MPP was co-eluted from a nickel-derivatized affinity resin, with a 1:1 stochiometry, both with wild-type beta-MPP and with the mutants with alanine inserted after Ser114 and Ser314. Nickel 131-137 peptidase, mitochondrial processing subunit alpha Homo sapiens 100-109 9352311-16 1997 Contractions to ET-1 were more potently inhibited by nickel (Ni2+, 0.3 mM), whereas nifedipine (1 microM) and cadmium (Cd2+, 0.1 mM) induced only a slight effect. Nickel 53-59 endothelin 1 Bos taurus 16-20 9299349-3 1997 When the alpha-subunit (alpha-MPP) was co-expressed with N-terminal hexa-histidine tagged beta-MPP, alpha-MPP was co-eluted from a nickel-derivatized affinity resin, with a 1:1 stochiometry, both with wild-type beta-MPP and with the mutants with alanine inserted after Ser114 and Ser314. Nickel 131-137 peptidase, mitochondrial processing subunit alpha Homo sapiens 24-33 9307035-2 1997 The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or nickel-agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant. Nickel 200-206 glutathione S-transferase theta 1 Homo sapiens 24-58 9275172-0 1997 Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif. Nickel 37-43 ribonuclease A family member 1, pancreatic Homo sapiens 57-64 9275172-1 1997 We report the crystal structures of the copper and nickel complexes of RNase A. Nickel 51-57 ribonuclease A family member 1, pancreatic Homo sapiens 71-78 9275172-6 1997 Consequently, the copper- and nickel-ion-bound dimers of RNase A act as nucleation sites for generating different crystal lattices for the two complexes. Nickel 30-36 ribonuclease A family member 1, pancreatic Homo sapiens 57-64 9328176-0 1997 Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II). Nickel 122-128 nudix hydrolase 1 Homo sapiens 50-54 9337084-3 1997 The recombinant P70 (rP70) protein with a 6Xhistidine affinity tag at its amino terminus was purified from E. coli via nickel affinity column chromatography. Nickel 119-125 interleukin 2 receptor, beta chain Mus musculus 16-19 9303338-0 1997 TAP1 and TAP2 genes in nickel allergy. Nickel 23-29 transporter 1, ATP binding cassette subfamily B member Homo sapiens 0-4 9303338-0 1997 TAP1 and TAP2 genes in nickel allergy. Nickel 23-29 transporter 2, ATP binding cassette subfamily B member Homo sapiens 9-13 9303338-1 1997 The study was undertaken to see whether TAP1 and TAP2 (transporter associated with antigen processing) genes are involved in susceptibility to nickel allergy. Nickel 143-149 transporter 1, ATP binding cassette subfamily B member Homo sapiens 40-44 9303338-1 1997 The study was undertaken to see whether TAP1 and TAP2 (transporter associated with antigen processing) genes are involved in susceptibility to nickel allergy. Nickel 143-149 transporter 2, ATP binding cassette subfamily B member Homo sapiens 49-53 9303338-1 1997 The study was undertaken to see whether TAP1 and TAP2 (transporter associated with antigen processing) genes are involved in susceptibility to nickel allergy. Nickel 143-149 transporter 1, ATP binding cassette subfamily B member Homo sapiens 55-101 9267568-0 1997 Diagnostic implications of p53 protein reactivity in nasal mucosa of nickel workers. Nickel 69-75 tumor protein p53 Homo sapiens 27-30 9267568-1 1997 OBJECTIVE: To investigate whether the quantitation of p53 protein reactivity in nasal biopsies could be related to nickel exposure by comparing nickel workers with various control groups. Nickel 115-121 tumor protein p53 Homo sapiens 54-57 9267568-5 1997 RESULTS: p53 Protein reactivity was found in 54% (49/93) of nickel workers, 50% (17/34) of office staff members, 67% (4/6) of hospital attendants. Nickel 60-66 tumor protein p53 Homo sapiens 9-12 9267568-11 1997 CONCLUSION: Accumulation of p53 protein in nickel workers seems not to be attributable to nickel exposure. Nickel 43-49 tumor protein p53 Homo sapiens 28-31 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 60-76 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 78-87 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interleukin 2 Homo sapiens 90-108 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interleukin 4 Homo sapiens 113-117 9268679-3 1997 A His tag on the COOH-terminus of the alpha 1 and beta 1 subunits allowed rapid purification of the heterodimeric form of guanylyl cyclase in a single affinity step using a nickel column. Nickel 173-179 adrenoceptor alpha 1D Homo sapiens 38-56 9228077-7 1997 This ectodomain variant was partially purified using sequential lectin and nickel-chelate chromatography, permitting the first direct visualization and quantitation of the mammalian TSHR. Nickel 75-81 thyroid stimulating hormone receptor Homo sapiens 182-186 9220017-4 1997 The recombinant plasmids were transfected into E. coli cells and PTHrP synthesis was induced by addition of 1 mM isopropyl-beta-D-thiogalactopyranoside (IPTG) at 37 degrees C. The recombinant fusion proteins were purified by binding of the histidine residues to a nickel column followed by gradient elusion and dialysis. Nickel 264-270 parathyroid hormone-like hormone Rattus norvegicus 65-70 9173976-7 1997 (iii) In fibroblasts under non-overexpression conditions a portion of SUG1 is bound to the TFIIH holocomplex as deduced from co-purification, immunopurification and nickel-chelate affinity chromatography using functional tagged TFIIH. Nickel 165-171 proteasome 26S subunit, ATPase 5 Homo sapiens 70-74 9173976-7 1997 (iii) In fibroblasts under non-overexpression conditions a portion of SUG1 is bound to the TFIIH holocomplex as deduced from co-purification, immunopurification and nickel-chelate affinity chromatography using functional tagged TFIIH. Nickel 165-171 ERCC excision repair 3, TFIIH core complex helicase subunit Homo sapiens 91-96 8987780-9 1997 With use of cadmium and nickel ions as selective blockers, it was found that in different sensory nuclei the presynaptic influx of calcium could result either from the activation of voltage-dependent calcium channels or from a direct influx through nAChR channels. Nickel 24-30 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 249-254 9155262-6 1997 The increases in ACE inactivation lifetime caused by the nickel chelates were anomalously large. Nickel 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-20 9163329-5 1997 The recombinant SP-D was purified on a nickel column and then on a maltose-agarose column. Nickel 39-45 surfactant protein D Homo sapiens 16-20 9126381-1 1997 The complex formed between 32P-labeled (dT)15 and a hexahistidine (6-His)-tagged anti-single-stranded DNA (ssDNA) Fab, DNA-1, was trapped by addition of nickel-chelating nitrilotriacetic acid (Ni-NTA) agarose that led to efficient separation of bound ligand from free. Nickel 153-159 FA complementation group B Homo sapiens 114-117 9258471-3 1997 In this paper, the results of experiments designed to determine the influence of metallic carcinogens such as nickel (Ni), lead (Pb), mercury (Hg), and cadmium (Cd), on CAT activity are reported. Nickel 110-116 catalase Homo sapiens 169-172 9060994-0 1997 Nickel is a specific antagonist for the catabolism of activated alpha 2-macroglobulin. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 64-85 9060994-2 1997 We previously reported that nickel (Ni2+) specifically inhibits the binding of activated alpha 2-macroglobulin (alpha 2 M*) at 4 degrees C to LRP and had no effect on the binding of other ligands to the receptor (Hussain et al. Nickel 28-34 alpha-2-macroglobulin Homo sapiens 89-110 9060994-2 1997 We previously reported that nickel (Ni2+) specifically inhibits the binding of activated alpha 2-macroglobulin (alpha 2 M*) at 4 degrees C to LRP and had no effect on the binding of other ligands to the receptor (Hussain et al. Nickel 28-34 alpha-2-macroglobulin Homo sapiens 112-121 9060994-2 1997 We previously reported that nickel (Ni2+) specifically inhibits the binding of activated alpha 2-macroglobulin (alpha 2 M*) at 4 degrees C to LRP and had no effect on the binding of other ligands to the receptor (Hussain et al. Nickel 28-34 LDL receptor related protein 1 Homo sapiens 142-145 9060994-6 1997 Nickel completely inhibited the degradation of alpha 2M* over a wide range of concentrations (0.3-2.4 nM); 50% inhibition for the degradation of 1.2 nM alpha 2M* was observed at 0.5 mM Ni2+. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 47-55 9060994-6 1997 Nickel completely inhibited the degradation of alpha 2M* over a wide range of concentrations (0.3-2.4 nM); 50% inhibition for the degradation of 1.2 nM alpha 2M* was observed at 0.5 mM Ni2+. Nickel 0-6 alpha-2-macroglobulin Homo sapiens 152-160 9060994-7 1997 Furthermore, nickel inhibited the binding, internalization and degradation of 125I-alpha 2M* in a dose- and time-dependent manner. Nickel 13-19 alpha-2-macroglobulin Homo sapiens 83-91 9084910-2 1997 In the presence of a peracid such as monopersulfate, HSO5-, nickel induced the monomeric RNase A to form dimers, trimers, tetramers, and higher oligomers without producing fragmentation of the polypeptide backbone. Nickel 60-66 ribonuclease pancreatic Bos taurus 89-96 9037002-5 1997 Skin-derived nickel-specific TCC of each patient secreted significantly more IL-4 than blood-derived TCC of the same individual. Nickel 13-19 interleukin 4 Homo sapiens 77-81 9102401-4 1997 In contrast, native HPRG bound to hydrazide or nickel chelate surfaces strongly stimulated the activation of plasminogen by tissue plasminogen activator, but not by urokinase or streptokinase. Nickel 47-53 histidine rich glycoprotein Homo sapiens 20-24 9027736-3 1997 Epo production is induced not only by hypoxia but also by certain transition metal (cobalt and nickel) and by iron chelation. Nickel 95-101 erythropoietin Homo sapiens 0-3 9013800-1 1997 Two different forms of oxytocinase (L-cystine aminopeptidase, CAP; EC 3.4.11.3) were purified from the 9000 g and 105000 g precipitate fractions of human placenta homogenate by sequential chromatography on columns of hydroxyapatite, DE-32, nickel ion affinity, and Sephadex G-200. Nickel 240-246 leucyl and cystinyl aminopeptidase Homo sapiens 23-34 9034683-4 1997 LIF mRNA expression was significantly increased in nickel-tested skin compared with both vehicle-tested (p = 0.045) and non-tested skin (p = 0.041). Nickel 51-57 LIF interleukin 6 family cytokine Homo sapiens 0-3 9118972-3 1997 Inhibition of glutathione synthesis or catalase activity increased the enhancing effect of nickel on the cytotoxicity of ultraviolet (UV) light. Nickel 91-97 catalase Bos taurus 39-47 9118972-4 1997 Inhibition of catalase and glutathione peroxidase activities also enhanced the retardation effect of nickel on the rejoining of DNA strand breaks accumulated by hydroxyurea plus cytosine-beta-D-arabinofuranoside in UV-irradiated cells. Nickel 101-107 catalase Bos taurus 14-22 9118972-6 1997 Nickel inhibition of the incorporation of (3H)dTTP into the DNase I-activated calf thymus DNA was stronger than the ligation of poly(dA) x oligo(dT), whereas H2O2 was more potent in inhibiting DNA ligation than DNA polymerization. Nickel 0-6 deoxyribonuclease 1 Bos taurus 60-67 8752137-10 1996 In addition, NK2 and NK3 receptor-mediated [Ca2+]i increase was partially attenuated in the absence of extracellular Ca2+ or in the presence of nickel, an inorganic Ca2+ influx blocker, but was unaffected by nifedipine and omega-conotoxin, L- and N-type voltage-dependent Ca2+ channel blockers, respectively. Nickel 144-150 hepatocyte growth factor Mus musculus 13-16 8993464-10 1996 However, when VIP was added at 10(-6) and 10(-5) mol/L, a higher level of interferon gamma was found in the nickel-treated cell cultures compared to the controls. Nickel 108-114 vasoactive intestinal peptide Homo sapiens 14-17 8993464-10 1996 However, when VIP was added at 10(-6) and 10(-5) mol/L, a higher level of interferon gamma was found in the nickel-treated cell cultures compared to the controls. Nickel 108-114 interferon gamma Homo sapiens 74-90 8952695-4 1996 The prompt AII-induced [Ca2+]i spike was not affected by incubating HCEC in Ca(2+)-free medium containing 2 mM EGTA or by pretreating the cultures with the Ca2+ channel blockers, methoxyverapamil (D600; 50 microM), nickel (1 mM), or lanthanum (1 mM), suggesting that the activation of AII receptors on HCEC triggers the release of Ca2+ from intracellular stores. Nickel 215-221 angiotensinogen Homo sapiens 11-14 8954887-7 1996 Recombinant TP2 was purified from the soluble extract of E. coli using nickel-agarose and heparin-agarose chromatography and was shown to be identical to native rat TP2 as revealed by immunoblotting with anti-rat TP2 antibodies and radioactive 65Zn-blotting. Nickel 71-77 transition protein 2 Rattus norvegicus 12-15 8942655-3 1996 N-His (D381E) ICE was expressed in Escherichia coli and purified by nickel-chelating Sepharose and size-exclusion chromatography (SEC). Nickel 68-74 caspase 1 Homo sapiens 14-17 21127642-1 1996 A photolithographic process has been used to form cross-shaped patterns in 3-mum-thick nickel foils. Nickel 87-93 latexin Homo sapiens 77-80 8910332-9 1996 These results suggest that nickel-chelate chromatography may be a suitable method for studying protein-protein interactions in membrane proteins and that the minimal functional unit of P-glycoprotein is likely to be a monomer. Nickel 27-33 ATP binding cassette subfamily B member 1 Homo sapiens 185-199 8887631-4 1996 Mcb1 copurified with the 26S proteasome in both conventional and nickel chelate chromatography. Nickel 65-71 proteasome regulatory particle base subunit RPN10 Saccharomyces cerevisiae S288C 0-4 8816425-8 1996 Although this effect is zinc specific, other divalent ions, like cobalt and nickel, with a complex structure and size comparable to those of zinc also enhance LPS-induced monokine secretion but to a much lesser extent. Nickel 76-82 interferon regulatory factor 6 Homo sapiens 159-162 8857506-8 1996 Moreover, nickel-deficient rats had significantly lower activities of the lipogenic enzymes glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, malic enzyme and fatty acid synthase than nickel-adequate rats. Nickel 10-16 glucose-6-phosphate dehydrogenase Rattus norvegicus 92-125 8857506-8 1996 Moreover, nickel-deficient rats had significantly lower activities of the lipogenic enzymes glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, malic enzyme and fatty acid synthase than nickel-adequate rats. Nickel 10-16 fatty acid synthase Rattus norvegicus 178-197 8842143-6 1996 Nodule bacteroids produced by hypX mutants in pea (Pisum sativum L.) plants grown at optimal nickel concentrations (100 microM) for hydrogenase expression, exhibited less than 5% of the wild-type levels of hydrogenase activity. Nickel 93-99 HPT Homo sapiens 30-34 8842143-8 1996 The Hup-deficient mutants were complemented for normal hydrogenase activity and nickel-dependent maturation of HupL by a hypX gene provided in trans. Nickel 80-86 HPT Homo sapiens 121-125 8752137-10 1996 In addition, NK2 and NK3 receptor-mediated [Ca2+]i increase was partially attenuated in the absence of extracellular Ca2+ or in the presence of nickel, an inorganic Ca2+ influx blocker, but was unaffected by nifedipine and omega-conotoxin, L- and N-type voltage-dependent Ca2+ channel blockers, respectively. Nickel 144-150 tachykinin receptor 3 Mus musculus 21-33 27327385-4 1996 METHODS: CaF2 :Dy or CaF2 was sensitized to UV by heating for 1-3 h to 750-950(o) C on different supports (porcelain, steel, preheated steel, silicon, chromium, manganese, iron, cobalt, nickel, copper, Fe2 O3 , Fe3 O4 ). Nickel 186-192 CCR4-NOT transcription complex subunit 8 Homo sapiens 9-13 27327385-4 1996 METHODS: CaF2 :Dy or CaF2 was sensitized to UV by heating for 1-3 h to 750-950(o) C on different supports (porcelain, steel, preheated steel, silicon, chromium, manganese, iron, cobalt, nickel, copper, Fe2 O3 , Fe3 O4 ). Nickel 186-192 CCR4-NOT transcription complex subunit 8 Homo sapiens 21-25 8661518-0 1996 Free peripheral sulfhydryl groups, CD11/CD18 integrins, and calcium are required in the cadmium and nickel enhancement of human-polymorphonuclear leukocyte adherence. Nickel 100-106 integrin subunit beta 2 Homo sapiens 40-44 8832391-3 1996 These localised Ca2+ changes resulted from the release of Ca2+ from intracellular stores, and were not inhibited by removal of extracellular Ca2+ or by the Ca2+ channel blocking nickel ions. Nickel 178-184 carbonic anhydrase 2 Homo sapiens 16-19 8757974-8 1996 VLP collected from sucrose density gradient fractions contained protein which reacted with nickel chelated to nitrilotriacetic acid, a histidine-specific reagent. Nickel 91-97 VHL like Homo sapiens 0-3 11666554-0 1996 Structure and Magnetic Properties of a Heptanuclear Nickel(II) Compound: [Ni(7)(&mgr;-NO(2))(8)(&mgr;(2)-OH)(2)(&mgr;(3)-OH)(2)(OHpn)(2)(Opn)(2)](2).7H(2)O. Nickel 52-58 secreted phosphoprotein 1 Homo sapiens 149-152 8660366-1 1996 Both in vivo and in Hep3B cells, expression of the erythropoietin gene is induced by hypoxia as well as by certain transition metals (cobalt and nickel) and by iron chelation. Nickel 145-151 erythropoietin Homo sapiens 51-65 8661518-3 1996 Cadmium or nickel, nullified the FMLP inhibitory effect, and enhanced the adherence. Nickel 11-17 formyl peptide receptor 1 Homo sapiens 33-37 8661518-9 1996 Therefore, the results indicate that cadmium and nickel adherence stimulation depends on constitutive peripheral SH groups, CD11/CD18 integrins and extracellular calcium, but not on intracellular stored-calcium release through ryanodine-sensitive channels (RyRS). Nickel 49-55 integrin subunit beta 2 Homo sapiens 129-133 8605204-2 1996 A polyhistidine extension was incorporated at the C-terminus of the expressed protein, which, after purification of the protein on a nickel-agarose column, could be removed proteolytically by treatment with thrombin. Nickel 133-139 coagulation factor II, thrombin Homo sapiens 207-215 8647121-2 1996 Recombinant yeast ATF, modified and extended by an amino-terminal in-frame insertion of a His6 tract, was purified from total protein extracts by nickel chelate affinity chromatography and shown to be functionally active since it efficiently competes with uPA for binding to cell-surface-associated uPAR. Nickel 146-152 glial cell derived neurotrophic factor Homo sapiens 18-21 8647124-14 1996 The solubilized CCKB receptors with C-terminal histidine tag retained their ligand binding characteristics after chromatography on a nickel affinity matrix. Nickel 133-139 cholecystokinin B receptor Homo sapiens 16-20 8617783-3 1996 The combined effect of two histidine mutants, E30H and Q62H, gave thioredoxin the capacity to bind to nickel ions immobilized on iminodiacetic acid- and nitrilotriacetic acid-Sepharose resins. Nickel 102-108 thioredoxin Homo sapiens 66-77 20650202-0 1996 In vitro effects of cadmium and nickel on glutathione, lipid peroxidation and glutathione S-transferase in human kidney. Nickel 32-38 glutathione S-transferase kappa 1 Homo sapiens 78-103 8814914-2 1996 Using nickel and cobalt to enhance the diaminobenzidine reaction product, we observed large layer V pyramidal cells with parvalbumin-like immunoreactivity in the primary motor cortex (area 4) and somatosensory cortex of adult macaque monkeys and galagos, including giant Betz cells in area 4. Nickel 6-12 parvalbumin Homo sapiens 121-132 8628401-5 1996 Sug1 co-purifies with the proteasome in both conventional and nickel-chelate affinity chromatography. Nickel 62-68 proteasome regulatory particle base subunit RPT6 Saccharomyces cerevisiae S288C 0-4 8725357-6 1996 In nickel sensitive patients, there was a significant increase of DRB4 (p < 0.05) but no significant association of DRB1 nor DQ locus, although there was an increase of DRB1*0405 (R.R = 2.36). Nickel 3-9 major histocompatibility complex, class II, DR beta 4 Homo sapiens 66-70 8725357-6 1996 In nickel sensitive patients, there was a significant increase of DRB4 (p < 0.05) but no significant association of DRB1 nor DQ locus, although there was an increase of DRB1*0405 (R.R = 2.36). Nickel 3-9 major histocompatibility complex, class II, DR beta 1 Homo sapiens 172-176 8579594-3 1996 Recombinant APOBEC-1 has been engineered to bind nickel resin and used in affinity chromatography of the auxiliary proteins from McArdle rat hepatoma cell extracts. Nickel 49-55 apolipoprotein B mRNA editing enzyme catalytic subunit 1 Rattus norvegicus 12-20 9630891-3 1996 A hexahistidine tag has been incorporated to allow rapid purification of scFv by nickel chelate chromatography. Nickel 81-87 immunglobulin heavy chain variable region Homo sapiens 73-77 8571389-3 1996 Other heavy metals including lead, manganese, mercury and nickel also decreased the t-PA:Ag and PAI-1:Ag release, however, cadmium was the most potent inhibitor. Nickel 58-64 plasminogen activator, tissue type Homo sapiens 84-88 8571389-3 1996 Other heavy metals including lead, manganese, mercury and nickel also decreased the t-PA:Ag and PAI-1:Ag release, however, cadmium was the most potent inhibitor. Nickel 58-64 serpin family E member 1 Homo sapiens 96-112 8554346-4 1996 The isolation of the soluble form of rSPARC was accomplished by anion-exchange, nickel-chelate affinity, and gel filtration chromatographies. Nickel 80-86 secreted protein acidic and cysteine rich Rattus norvegicus 37-43 8911636-2 1996 Samples containing nickel (III), of low crystallinity, with small particle size and high surface areas can in the presence of H2O2, cause the generation of the hydroxyl radical (as detected by spin trapping with 5,5-dimethyl-1-pyrroline N-oxide or DMPO) and/or another highly reactive species capable of cleaving the C-S bond in dimethyl sulphoxide. Nickel 19-25 spindlin 1 Homo sapiens 193-197 9526549-4 1996 The recombinant UL12 protein purified by nickel-chelating affinity chromatography exhibited both exonuclease and endonuclease activity, each with an alkaline pH optimum. Nickel 41-47 deoxyribonuclease Bovine alphaherpesvirus 1 16-20 9022264-6 1996 PMN from nickel sensitized donors exhibited a significant enhancement of hydrogen peroxide (H2O2) and myeloperoxidase release. Nickel 9-15 myeloperoxidase Homo sapiens 102-117 9013493-4 1996 A one-step purification procedure using nickel-chelating affinity chromatography resulted in a homogeneous preparation of this protein, which displayed specific UDGase activity in an in vitro enzyme assay. Nickel 40-46 uracil DNA glycosylase Bovine alphaherpesvirus 1 161-167 8519764-0 1995 Nickel is a specific inhibitor for the binding of activated alpha 2-macroglobulin to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Nickel 0-6 alpha-2-macroglobulin Rattus norvegicus 60-81 8519764-0 1995 Nickel is a specific inhibitor for the binding of activated alpha 2-macroglobulin to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Nickel 0-6 LOW QUALITY PROTEIN: alpha-2-macroglobulin Oryctolagus cuniculus 138-159 8519764-10 1995 The specific binding of alpha 2-M* to the immobilized receptor was inhibited in the presence of nickel. Nickel 96-102 alpha-2-macroglobulin Rattus norvegicus 24-33 8706409-0 1995 HLA DR, DQA, DQB and DP antigens in patients allergic to nickel. Nickel 57-63 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 13-16 8566016-4 1995 They were shown to recognize nickel in the context of major histocompatibility complex (MHC) class II molecules and to belong to the CD4 subset. Nickel 29-35 CD4 molecule Homo sapiens 133-136 7492570-5 1995 Exposure of cells to zinc, copper or nickel ions induced an orientation reaction in leukocytes in a similar fashion as the polarization reaction induced by a potent peptide chemoattractant, N-formylmethionylleucylphenylalanine (fMLP), in these cells. Nickel 37-43 formyl peptide receptor 1 Homo sapiens 228-232 7492570-6 1995 Exposure of PMN cells to zinc or nickel in chemotactic concentrations stimulated the chemotaxis of these cells to fMLP 2-fold, whereas pretreatment of the cells with zinc prior to assay markedly decreased the subsequent chemotactic migration of the cells to this metal or to fMLP. Nickel 33-39 formyl peptide receptor 1 Homo sapiens 114-118 7492570-6 1995 Exposure of PMN cells to zinc or nickel in chemotactic concentrations stimulated the chemotaxis of these cells to fMLP 2-fold, whereas pretreatment of the cells with zinc prior to assay markedly decreased the subsequent chemotactic migration of the cells to this metal or to fMLP. Nickel 33-39 formyl peptide receptor 1 Homo sapiens 275-279 9980266-0 1995 Spin-resolved 3p and 3s core-level photoemission spectra of ferromagnetic nickel. Nickel 74-80 spindlin 1 Homo sapiens 0-4 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 negative elongation factor complex member C/D Homo sapiens 51-54 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 interferon gamma Homo sapiens 117-126 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 interleukin 4 Homo sapiens 145-149 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 interleukin 5 Homo sapiens 154-158 7671317-5 1995 These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern. Nickel 23-29 interleukin 5 Homo sapiens 68-72 7671317-5 1995 These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern. Nickel 23-29 interferon gamma Homo sapiens 97-106 7671317-5 1995 These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern. Nickel 23-29 interleukin 4 Homo sapiens 111-115 8575939-4 1995 The immunohistochemical demonstration of nNOS, using the nickel enhancement technique, shows positive reaction product over the dendrites and the soma of the nerve cell in the rat brain. Nickel 57-63 nitric oxide synthase 1 Rattus norvegicus 41-45 7577754-4 1995 With the anti-PCNA antibodies, nickel-cobalt enhancement of the reaction product was found to augment the granular nature of nuclear staining, corresponding more closely to patterns observed in cell culture studies. Nickel 31-37 proliferating cell nuclear antigen Homo sapiens 14-18 7591059-5 1995 The M. tuberculosis IdeR protein was overexpressed in E. coli and purified to near homogeneity by nickel affinity chromatography. Nickel 98-104 iron-dependent repressor and activator IdeR Mycobacterium tuberculosis H37Rv 20-24 7665554-0 1995 Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities. Nickel 93-99 ATP binding cassette subfamily B member 1 Homo sapiens 28-42 7665554-1 1995 P-glycoprotein containing 10 tandem histidine residues at the COOH end of the molecule was transiently expressed in HEK 293 cells and purified by nickel-chelate chromatography. Nickel 146-152 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 7615812-7 1995 ET-1-induced RMIC contraction was not altered by nifedipine, was partially reduced by nickel, and was completely inhibited by H7, indicating that ET-1 action is mediated by protein kinase C and is partially dependent upon receptor-operated calcium channels. Nickel 86-92 endothelin 1 Rattus norvegicus 0-4 9977803-0 1995 Spin-resolved x-ray photoemission from ferromagnetic nickel. Nickel 53-59 spindlin 1 Homo sapiens 0-4 7757970-2 1995 We produced a recombinant MAGE-3 gene product by expression cloning of the entire reading frame in the context of a fusion protein characterized by a 10-histidine tail, allowing purification by metal chelation on a nickel Sepharose column. Nickel 215-221 MAGE family member A3 Homo sapiens 26-32 7538678-5 1995 Possible involvement of a heme-containing oxygen sensor in MP elaboration of growth factors was suggested by the induction of bFGF and PDGF by normoxic MPs exposed to nickel or cobalt, although metabolic inhibitors such as sodium azide were without effect. Nickel 167-173 fibroblast growth factor 2 Homo sapiens 126-130 7588568-6 1995 Recombinant uPAR from E. coli (corresponding to amino acids 1-284 of human uPAR) was expressed with an N-terminal histidine-tag insertion and purified by nickel chelate affinity chromatography. Nickel 154-160 urokinase plasminogen activator surface receptor Cricetulus griseus 12-16 7588568-6 1995 Recombinant uPAR from E. coli (corresponding to amino acids 1-284 of human uPAR) was expressed with an N-terminal histidine-tag insertion and purified by nickel chelate affinity chromatography. Nickel 154-160 plasminogen activator, urokinase receptor Homo sapiens 75-79 7537850-1 1995 A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Nickel 94-100 alanine aminotransferase 1 Cricetulus griseus 13-16 7537850-1 1995 A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Nickel 94-100 alanine aminotransferase 1 Cricetulus griseus 125-128 7537850-2 1995 Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as indicated by both reversion assays and direct enzyme measurements. Nickel 5-11 glutamic--pyruvic transaminase Homo sapiens 96-99 7537850-3 1995 Since reversion was enhanced in many of the nickel-induced variant cell lines following 24-h treatment with the demethylating agent 5-azacytidine, the involvement of DNA methylation in silencing gpt expression was suspected. Nickel 44-50 glutamic--pyruvic transaminase Homo sapiens 195-198 7537850-7 1995 This mechanism is supported by direct evidence showing that acute nickel treatment of cultured cells, and of isolated nuclei in vitro, can indeed facilitate gpt sequence-specific chromatin condensation. Nickel 66-72 glutamic--pyruvic transaminase Homo sapiens 157-160 7614006-5 1995 Cobalt and nickel, but not zinc, significantly increased DOR expression. Nickel 11-17 opioid receptor, delta 1 Mus musculus 57-60 8543477-3 1995 E) mediated enhancement of nickel toxicity was demonstrated by (i) enhanced mortality in mice treated with Ni and Vit. Nickel 27-33 vitrin Mus musculus 114-117 7794816-0 1995 Nickel and skin irritants up-regulate tumor necrosis factor-alpha mRNA in keratinocytes by different but potentially synergistic mechanisms. Nickel 0-6 tumor necrosis factor Mus musculus 38-65 7747530-5 1995 Using FACS analysis, we showed that the combination of zinc with nickel or the addition of ZnSO4 24 h before IFN-gamma or NiSO4 treatments reduced ICAM-1 expression on the keratinocyte surface (p < 0.01). Nickel 65-71 intercellular adhesion molecule 1 Homo sapiens 147-153 8830494-9 1995 The putative ORF3 product which had been tagged by a 6 Histidine tail, was expressed in E. coli and purified by nickel chelate affinity chromatography before 2-dimensional polyacrylamide gel electrophoresis and immunostaining with a rabbit anti-peptide serum directed against the N-terminus of the ORF3 product. Nickel 112-118 hypothetical protein Escherichia coli 13-17 8722046-5 1995 Whereas CLA+ T cells from AD patients preferentially responded to house dust mite (HDM) and CLA+ T cells from nickel CD patients showed an increased response to nickel, CLA-T cells showed very little response in both cases. Nickel 110-116 selectin P ligand Homo sapiens 92-95 8722046-5 1995 Whereas CLA+ T cells from AD patients preferentially responded to house dust mite (HDM) and CLA+ T cells from nickel CD patients showed an increased response to nickel, CLA-T cells showed very little response in both cases. Nickel 110-116 selectin P ligand Homo sapiens 92-95 7591581-0 1995 Effect of recombinant human erythropoietin (rHuEPO) on protein, zinc (Zn), nickel (Ni) and manganese (Mn) in patients undergoing chronic haemodialysis. Nickel 75-81 erythropoietin Homo sapiens 28-42 7705461-5 1994 Ryanodine, an inhibitor of intracellular Ca2+ mobilization, selectively endothelin-1-induced 45Ca2+ uptake, whereas nickel or suramin inhibited endothelin-3-induced 45Ca2+ uptake. Nickel 116-122 endothelin 3 Rattus norvegicus 144-156 7996430-0 1994 Inhibition by nickel of endothelin-1-induced tension and associated 45Ca movements in rabbit aorta. Nickel 14-20 endothelin-1 Oryctolagus cuniculus 24-36 7980570-3 1994 The recombinant polypeptide binds to and elutes from a nickel affinity resin (IMAC resin). Nickel 55-61 C-C motif chemokine ligand 26 Homo sapiens 78-82 7864660-3 1994 Our aim was to assess the effects of sensitizing metal haptens (nickel, cobalt and chromium) compared with the toxic metal cadmium on the induction of ICAM-1 and the production of TNF alpha by epidermal cells. Nickel 64-70 intercellular adhesion molecule 1 Homo sapiens 151-157 7929368-8 1994 Studies with the nickel-nitriloacetic acid-purified recombinant proteins demonstrated that the AHR and ARNT could bind DRE only when reconstituted with a heat-sensitive factor(s) present in soluble extracts from a variety of cell types. Nickel 17-23 aryl hydrocarbon receptor Homo sapiens 95-98 7929368-8 1994 Studies with the nickel-nitriloacetic acid-purified recombinant proteins demonstrated that the AHR and ARNT could bind DRE only when reconstituted with a heat-sensitive factor(s) present in soluble extracts from a variety of cell types. Nickel 17-23 aryl hydrocarbon receptor nuclear translocator Homo sapiens 103-107 7932762-0 1994 Crystallization and preliminary X-ray diffraction study of the nickel-binding protein NikA of Escherichia coli. Nickel 63-69 relaxosome component Escherichia coli 86-90 7932762-1 1994 NikA, a periplasmic nickel-binding protein involved in nickel-repellent chemotaxis has been crystallized. Nickel 20-26 relaxosome component Escherichia coli 0-4 7932762-1 1994 NikA, a periplasmic nickel-binding protein involved in nickel-repellent chemotaxis has been crystallized. Nickel 55-61 relaxosome component Escherichia coli 0-4 7929182-4 1994 Six histidine residues were fused to the N terminus of Hsp82 to yield a fusion protein (Hsp82FP) with affinity for a nickel-ion matrix. Nickel 117-123 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 55-60 7923911-4 1994 T cell lines initially cultured with IL-2 always gave better specific proliferative responses to nickel than those derived with PHA and IL-2. Nickel 97-103 interleukin 2 Homo sapiens 37-41 7923911-5 1994 Phenotypical analysis of the nickel-specific T cell lines showed that they were mainly composed of activated CD8+ TcR alpha beta + T lymphocytes. Nickel 29-35 CD8a molecule Homo sapiens 109-112 8063817-6 1994 Other divalent cations, such as magnesium, zinc, nickel, and cobalt, but not the trivalent cation lanthanum, induced p62 phosphorylation to a similar extent as calcium. Nickel 49-55 nucleoporin 62 Mus musculus 117-120 7519613-11 1994 Histidine-tagged NF45 and NF90 proteins, affinity-purified on nickel chelate columns, encode a NF-AT DNA-binding activity that is enhanced following T-cell stimulation, and this enhancement is blocked when T-cells are stimulated in the presence of cyclosporin A or FK506. Nickel 62-68 interleukin enhancer binding factor 2 Homo sapiens 17-21 7519613-11 1994 Histidine-tagged NF45 and NF90 proteins, affinity-purified on nickel chelate columns, encode a NF-AT DNA-binding activity that is enhanced following T-cell stimulation, and this enhancement is blocked when T-cells are stimulated in the presence of cyclosporin A or FK506. Nickel 62-68 interleukin enhancer binding factor 3 Homo sapiens 26-30 7917990-0 1994 Effect of nickel on the activation state of normal human keratinocytes through interleukin 1 and intercellular adhesion molecule 1 expression. Nickel 10-16 interleukin 1 alpha Homo sapiens 79-130 8029691-8 1994 The UreG protein is related in sequence to HypB, a protein that has been proposed to function in nickel processing in hydrogenases. Nickel 97-103 SET domain containing 2, histone lysine methyltransferase Homo sapiens 43-47 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interleukin 1 alpha Homo sapiens 0-10 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 23-39 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 41-50 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interleukin 1 alpha Homo sapiens 0-10 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 23-39 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 41-50 8209385-2 1994 We found that nickel induced a dose-dependent increase in the oxidation of bovine serum albumin (BSA) as detected by carbonyl formation in the presence of H2O2 in vitro, as well as producing carbonyl of proteins in intact cultured Chinese hamster ovary (CHO) cells. Nickel 14-20 albumin Cricetulus griseus 82-95 8168106-3 1994 The pRb was found only in the hypophosphorylated form in 8 of 9 nickel-transformed clones examined, whereas in the parental cells the pRb appeared in both phosphorylated and unphosphorylated forms. Nickel 64-70 RB transcriptional corepressor 1 Homo sapiens 4-7 8168106-5 1994 The nickel-transformed HOS clones expressed the major regulators of Rb phosphorylation, cyclin E and cdk-2, at levels similar to those of the parental cells. Nickel 4-10 cyclin dependent kinase 2 Homo sapiens 101-106 8162578-0 1994 The effect of divalent nickel (Ni2+) on in vitro DNA replication by DNA polymerase alpha. Nickel 23-29 DNA polymerase alpha 1, catalytic subunit Homo sapiens 68-88 8162578-1 1994 The effects of the carcinogenic metal nickel on DNA polymerase alpha (pol alpha) activity and fidelity have been analyzed. Nickel 38-44 DNA polymerase alpha 1, catalytic subunit Homo sapiens 48-68 7925247-3 1994 Addition of increasing amounts of nickel resulted in dose-dependent changes of the electrophoretic patterns of prealbumin, alpha-1-lipoprotein, alpha-1-antitrypsin and alpha-2-macroglobulin. Nickel 34-40 serpin family A member 1 Homo sapiens 144-163 7925247-3 1994 Addition of increasing amounts of nickel resulted in dose-dependent changes of the electrophoretic patterns of prealbumin, alpha-1-lipoprotein, alpha-1-antitrypsin and alpha-2-macroglobulin. Nickel 34-40 alpha-2-macroglobulin Homo sapiens 168-189 7925247-11 1994 The present study demonstrated that, besides the nickel-binding of albumin and alpha-2-macroglobulin, several other serum proteins have nickel-binding affinity. Nickel 49-55 alpha-2-macroglobulin Homo sapiens 79-100 8204311-10 1994 Significant correlations between urinary concentrations of nickel on one side and that of beta 2-m in women (r = 0.462, P = 0.022) and men (r = 0.41, P = 0.018) and of NAG in men (r = 0.405, P = 0.019) on the other side were found in exposed subjects. Nickel 59-65 O-GlcNAcase Homo sapiens 168-171 15299481-5 1994 Whereas the copper is best described as penta-coordinated, the nickel and manganese are best described as hexa-coordinated. Nickel 63-69 hexosaminidase subunit alpha Homo sapiens 106-110 7864660-3 1994 Our aim was to assess the effects of sensitizing metal haptens (nickel, cobalt and chromium) compared with the toxic metal cadmium on the induction of ICAM-1 and the production of TNF alpha by epidermal cells. Nickel 64-70 tumor necrosis factor Homo sapiens 180-189 7864660-5 1994 Using FACS analysis, ICAM-1 expression was found to be induced only by nickel. Nickel 71-77 intercellular adhesion molecule 1 Homo sapiens 21-27 7864660-10 1994 These results indicate that the metals studied are able to induce an aggressive cellular effect, and that nickel, by its ICAM-1 induction, may play a major role in the keratinocyte activation state during allergic contact dermatitis. Nickel 106-112 intercellular adhesion molecule 1 Homo sapiens 121-127 8395015-4 1993 Plc1p, modified by in-frame insertion of a His6 tract and a c-myc epitope near its amino terminus, was overexpressed from the GAL1 promoter, partially purified by nickel chelate affinity chromatography, and shown to be an active PLC enzyme in vitro with properties similar to those of its mammalian counterparts. Nickel 163-169 phospholipase C gamma 1 Homo sapiens 0-5 7508206-3 1994 With a bath Ca2+ concentration ([Ca2+]) of 1 mM, 10 nM SP elicited an increase in cytosolic [Ca2+] ([Ca2+]i) from a baseline of 25 +/- 4 nM to a peak of 808 +/- 120 nM, followed by a slowly declining plateau phase, which was absent in Ca(2+)-free bath and was abolished by addition of extracellular lanthanum or nickel. Nickel 312-318 tachykinin precursor 1 Homo sapiens 55-57 7850490-3 1994 Androgen receptor was visualized in coronal sections using nickel intensification of diaminobenzidine, and the neuropeptides were identified using a brown diaminobenzidine reaction product. Nickel 59-65 androgen receptor Rattus norvegicus 0-17 8248947-4 1993 Although nickel as well as cadmium increased the PAI-1:Ag release, the other heavy metals including cobalt, zinc and copper did not exhibit such a stimulatory effect. Nickel 9-15 serpin family E member 1 Homo sapiens 49-65 8368264-9 1993 We conclude that ET-1 mediates an increase in [Ca2+]i by Ca2+ release from intracellular stores and activation of a nickel- and nifedipine-sensitive Ca2+ entry mechanism. Nickel 116-122 endothelin 1 Mus musculus 17-21 7689045-1 1993 A nickel-coated surface was used to adsorb a monolayer of anti-human alpha-fetoprotein antibody. Nickel 2-8 alpha fetoprotein Homo sapiens 69-86 8388125-4 1993 Although it is structurally related to high voltage-activated calcium channels, the rbE-II channel transiently activated at negative membrane potentials, required a strong hyperpolarization to deinactivate, and was highly sensitive to block by nickel. Nickel 244-250 calcium voltage-gated channel subunit alpha1 E Rattus norvegicus 84-90 8100600-8 1993 Fos was visualized with nickel-intensified diaminobenzidine (Ni-DAB) in the first sequence while TH, PNMT, OT or VP were visualized with DAB alone, resulting in readily distinguishable black and amber reaction products, respectively. Nickel 24-30 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 8491216-0 1993 Mutagenicity of soluble and insoluble nickel compounds at the gpt locus in G12 Chinese hamster cells. Nickel 38-44 glutamic--pyruvic transaminase Homo sapiens 62-65 7682851-0 1993 Application of Raney nickel to measure adducts of styrene oxide with hemoglobin and albumin. Nickel 15-27 albumin Homo sapiens 84-91 7682851-3 1993 In a preliminary experiment with human blood, which had been modified with [14C]SO in vitro, it was determined that Ra-Ni released 6% of the total binding to globin and 76% of the total binding to Alb. Nickel 116-121 albumin Homo sapiens 197-200 8443960-0 1993 CD23/Fc epsilon R11 expression in contact sensitivity reactions: a comparison between aeroallergen patch test reactions in atopic dermatitis and the nickel patch test reaction in non-atopic individuals. Nickel 149-155 Fc epsilon receptor II Homo sapiens 0-4 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Nickel 47-53 hematopoietic prostaglandin D synthase Rattus norvegicus 74-99 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Nickel 47-53 hematopoietic prostaglandin D synthase Rattus norvegicus 101-104 8095057-0 1993 HLA-DR, -DQ and -DP alleles in nickel, chromium, and/or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymorphisms. Nickel 31-37 major histocompatibility complex, class II, DP beta 1 Homo sapiens 0-19 8095057-2 1993 We have previously described an association in nickel-sensitive subjects with an HLA-DQA restriction fragment length polymorphism (RFLP) (4.5-kb TaqI band, DQA1*0501). Nickel 47-53 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 81-88 8451539-0 1993 A nickel-binding serpin, pNiXa, induces maturation of Xenopus oocytes and shows synergism with oncogenic ras-p21 protein. Nickel 2-8 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 109-112 8074791-4 1993 Nickel from NiCl2 strongly activated SOD activity. Nickel 0-6 superoxide dismutase 1 Homo sapiens 37-40 8074791-7 1993 The combination of nickel and SOD may contribute to stabilization of the particular conformation of SOD responsible for maximal catalytically activity. Nickel 19-25 superoxide dismutase 1 Homo sapiens 100-103 8491216-2 1993 In this report we describe the mutational response to nickel compounds in the G12 cell line, an hprt deficient V79 cell line containing a single copy of the E. coli gpt gene. Nickel 54-60 glutamic--pyruvic transaminase Homo sapiens 165-168 8491216-5 1993 Of 48 mutant gpt(-) clones isolated that were induced by insoluble nickel, all were capable of DNA amplification of the gpt sequences by polymerase chain reaction (PCR). Nickel 67-73 glutamic--pyruvic transaminase Homo sapiens 13-16 8491216-5 1993 Of 48 mutant gpt(-) clones isolated that were induced by insoluble nickel, all were capable of DNA amplification of the gpt sequences by polymerase chain reaction (PCR). Nickel 67-73 glutamic--pyruvic transaminase Homo sapiens 120-123 8354570-0 1993 Urinary N-acetyl-beta-D-glucosaminidase and beta-aminoisobutyric acid in workers occupationally exposed to metals such as chromium, nickel, and iron. Nickel 132-138 O-GlcNAcase Homo sapiens 8-39 8453312-0 1993 HLA-DQA1 and DQB1 loci in nickel allergy patients. Nickel 26-32 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 0-8 8453312-0 1993 HLA-DQA1 and DQB1 loci in nickel allergy patients. Nickel 26-32 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 13-17 8453312-1 1993 Since an association has been reported between nickel allergy and HLA-DQA TaqI restriction fragment length polymorphism, we typed the DQA1 locus by a more precise method to confirm the association and characterize it better. Nickel 47-53 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 66-73 8453312-1 1993 Since an association has been reported between nickel allergy and HLA-DQA TaqI restriction fragment length polymorphism, we typed the DQA1 locus by a more precise method to confirm the association and characterize it better. Nickel 47-53 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 134-138 8354570-1 1993 To examine the relationships between the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and beta-aminoisobutyric acid (AIBA) as a metabolite of thymine, and exposure to chromium, nickel, and iron, we determined these parameters in 58 workers engaged in the cutting and grinding of stainless steel or iron-steel plates. Nickel 191-197 O-GlcNAcase Homo sapiens 95-98 8364257-3 1993 We have determined MGMT at the cellular level in a panel of pediatric rhabdomyosarcoma xenografts by in situ immunostaining with a human MGMT-specific antibody employing a very sensitive procedure that involves biotin-avidin coupled horseradish peroxidase with silver-enhanced diaminobenzidine-nickel staining. Nickel 294-300 O-6-methylguanine-DNA methyltransferase Homo sapiens 19-23 1283693-0 1992 Serum nickel levels of diabetic patients and healthy controls by AAS with a graphite furnace. Nickel 6-12 FYVE, RhoGEF and PH domain containing 1 Homo sapiens 65-68 1283693-1 1992 In this study, serum nickel levels of diabetic patients and healthy controls were determined by AAS with a graphite furnace. Nickel 21-27 FYVE, RhoGEF and PH domain containing 1 Homo sapiens 96-99 1327776-6 1992 D. desulfuricans ATCC 7757 hydrogenase was free of nickel and contained 14.0 atoms of iron and 14.4 atoms of acid-labile sulfur/molecule and had E400, 52.5 mM-1.cm-1. Nickel 51-57 DVU2400 Desulfovibrio vulgaris str. Hildenborough 27-38 1576706-8 1992 A normal CHE X chromosome induced senescence of 75% of hybrids obtained with another immortal and tumorigenic nickel-transformed male CHE cell line (Ni-6/TGR), which exhibited no visible deletion of the X chromosome, while the normal human X chromosome, only induced senescence in 19% of these hybrids. Nickel 110-116 thioredoxin reductase 3 Homo sapiens 154-157 1412503-0 1992 Combined effect of cadmium and nickel on rat hepatic monooxygenases: possible stimulation of certain cytochrome P-450 isozymes. Nickel 31-37 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 101-117 1512278-0 1992 Effects of the divalent cations nickel and cadmium on contractions of rat aorta to endothelin-1. Nickel 32-38 endothelin 1 Rattus norvegicus 83-95 1377732-3 1992 Nickel-enhanced development of avidin-biotin-peroxidase staining is used to show CGRP immunoreactivity in black and alkaline phosphatase-anti-alkaline phosphatase is applied to demonstrate incorporated BrdU in red. Nickel 0-6 calcitonin-related polypeptide alpha Rattus norvegicus 81-85 1448619-4 1992 The homology among the accessory proteins HypB, ORF4 and UreG suggests that the mechanism of nickel incorporation into hydrogenases in Escherichia coli is the same as or similar to that into hydrogenases of Rhodobacter capsulatus and into urease of Klebsiella aerogenes. Nickel 93-99 putative polysaccharide deacetylase Escherichia coli 48-52 16668768-6 1992 These results suggest that the bacterium living on the eu2/eu2 or eu3-e1/eu3-e1 mutant is unable to produce an active urease or hydrogenase because it is effectively starved for nickel. Nickel 178-184 Ni-binding urease accessory protein UreG Glycine max 66-69 16668768-6 1992 These results suggest that the bacterium living on the eu2/eu2 or eu3-e1/eu3-e1 mutant is unable to produce an active urease or hydrogenase because it is effectively starved for nickel. Nickel 178-184 Ni-binding urease accessory protein UreG Glycine max 73-76 1482271-9 1992 It is concluded that the products of the hypA-E genes play a role in nickel incorporation into hydrogenase apoprotein and/or processing of the constituent subunits of this enzyme. Nickel 69-75 hypA Escherichia coli 41-45 16668768-7 1992 We infer that mutations at Eu2 or Eu3 result in defects in nickel metabolism but not in Ni(2+) uptake or transport, because eu2/eu2 and eu3-e1/eu3-e1 mutants exhibit normal uptake of (63)NiCl(2). Nickel 59-65 Ni-binding urease accessory protein UreG Glycine max 34-37 16668768-7 1992 We infer that mutations at Eu2 or Eu3 result in defects in nickel metabolism but not in Ni(2+) uptake or transport, because eu2/eu2 and eu3-e1/eu3-e1 mutants exhibit normal uptake of (63)NiCl(2). Nickel 59-65 Ni-binding urease accessory protein UreG Glycine max 143-146 1533803-0 1992 Nickel effects on phosphate uptake, alkaline phosphatase, and ATPase of a cyanobacterium. Nickel 0-6 dynein axonemal heavy chain 8 Homo sapiens 62-68 1295674-6 1992 N-Methyl-D-aspartate receptor antagonists delay the onset of SD, while nickel and cobalt reduce the amplitude of SD-related redistribution of Ca2+. Nickel 71-77 carbonic anhydrase 2 Homo sapiens 142-145 1727381-0 1992 Altered p53 gene structure and expression in human epithelial cells after exposure to nickel. Nickel 86-92 tumor protein p53 Homo sapiens 8-11 1727381-3 1992 Immunocytochemistry and sequence analysis of DNA from the nickel-immortalized cells revealed abnormal p53 expression and a T----C transition mutation in codon 238. Nickel 58-64 tumor protein p53 Homo sapiens 102-105 1722265-9 1991 However, children residing in the city of Nis had significantly increased urinary beta 2m and albumin excretion, over 1.5 to 2.6 times the excretion in the other three groups, although excretion of either protein remained within accepted normal ranges in all groups. Nickel 42-45 beta-2-microglobulin Homo sapiens 82-89 1345823-0 1992 Th1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals. Nickel 38-44 negative elongation factor complex member C/D Homo sapiens 0-3 1345823-0 1992 Th1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals. Nickel 38-44 CD4 molecule Homo sapiens 54-57 1345823-0 1992 Th1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals. Nickel 83-89 negative elongation factor complex member C/D Homo sapiens 0-3 1345823-0 1992 Th1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals. Nickel 83-89 CD4 molecule Homo sapiens 54-57 1345823-8 1992 Because nickel-specific TLC from allergic and non-allergic individuals show a similar Th1 secretion pattern, the present results give no evidence that aberrant lymphokine secretion by CD4+T cells determines the contact allergic state, as was found for atopic allergy in a previous study. Nickel 8-14 negative elongation factor complex member C/D Homo sapiens 86-89 1919052-4 1991 In studies using antigen-presenting cells (APC) isolated from peripheral blood to present nickel, anti-LFA-1 alpha and/or LFA-1 beta MoAb partially inhibited the in vitro activation of nickel-specific T lymphocytes in nine of 42 patients allergic to nickel. Nickel 90-96 integrin subunit alpha L Homo sapiens 103-114 1919052-4 1991 In studies using antigen-presenting cells (APC) isolated from peripheral blood to present nickel, anti-LFA-1 alpha and/or LFA-1 beta MoAb partially inhibited the in vitro activation of nickel-specific T lymphocytes in nine of 42 patients allergic to nickel. Nickel 185-191 integrin subunit alpha L Homo sapiens 103-114 1919052-4 1991 In studies using antigen-presenting cells (APC) isolated from peripheral blood to present nickel, anti-LFA-1 alpha and/or LFA-1 beta MoAb partially inhibited the in vitro activation of nickel-specific T lymphocytes in nine of 42 patients allergic to nickel. Nickel 185-191 integrin subunit alpha L Homo sapiens 103-108 1919052-4 1991 In studies using antigen-presenting cells (APC) isolated from peripheral blood to present nickel, anti-LFA-1 alpha and/or LFA-1 beta MoAb partially inhibited the in vitro activation of nickel-specific T lymphocytes in nine of 42 patients allergic to nickel. Nickel 185-191 integrin subunit alpha L Homo sapiens 103-114 1919052-4 1991 In studies using antigen-presenting cells (APC) isolated from peripheral blood to present nickel, anti-LFA-1 alpha and/or LFA-1 beta MoAb partially inhibited the in vitro activation of nickel-specific T lymphocytes in nine of 42 patients allergic to nickel. Nickel 185-191 integrin subunit alpha L Homo sapiens 103-108 1919052-9 1991 Anti-CD2 and anti-LFA-3 MoAb strongly inhibited the proliferative responses of nickel-specific peripheral blood T lymphocytes from all 42 patients. Nickel 79-85 CD2 molecule Homo sapiens 5-8 1919052-9 1991 Anti-CD2 and anti-LFA-3 MoAb strongly inhibited the proliferative responses of nickel-specific peripheral blood T lymphocytes from all 42 patients. Nickel 79-85 CD58 molecule Homo sapiens 18-23 1919052-10 1991 These results indicated that the receptor-ligand interaction between CD2 and LFA-3 is essential for in vitro activation of nickel-specific peripheral blood T lymphocytes. Nickel 123-129 CD2 molecule Homo sapiens 69-72 1919052-10 1991 These results indicated that the receptor-ligand interaction between CD2 and LFA-3 is essential for in vitro activation of nickel-specific peripheral blood T lymphocytes. Nickel 123-129 CD58 molecule Homo sapiens 77-82 1919052-12 1991 The involvement of LFA-1 in the activation of nickel-specific T lymphocytes correlated positively with high patch test scores to nickel and the disease activity in contact dermatitis patients. Nickel 46-52 integrin subunit alpha L Homo sapiens 19-24 1919052-12 1991 The involvement of LFA-1 in the activation of nickel-specific T lymphocytes correlated positively with high patch test scores to nickel and the disease activity in contact dermatitis patients. Nickel 129-135 integrin subunit alpha L Homo sapiens 19-24 1722265-9 1991 However, children residing in the city of Nis had significantly increased urinary beta 2m and albumin excretion, over 1.5 to 2.6 times the excretion in the other three groups, although excretion of either protein remained within accepted normal ranges in all groups. Nickel 42-45 albumin Homo sapiens 94-101 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 intercellular adhesion molecule 1 Homo sapiens 94-100 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 intercellular adhesion molecule 1 Homo sapiens 354-360 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 integrin subunit alpha L Homo sapiens 215-220 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 56-62 intercellular adhesion molecule 1 Homo sapiens 94-100 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 56-62 integrin subunit alpha L Homo sapiens 215-220 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 integrin subunit alpha L Homo sapiens 275-280 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 intercellular adhesion molecule 1 Homo sapiens 354-360 1682230-3 1991 In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules. Nickel 3-9 integrin subunit alpha L Homo sapiens 275-280 1905729-4 1991 Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry. Nickel 20-26 ras homolog family member A Bos taurus 40-44 1905729-4 1991 Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry. Nickel 20-26 ras homolog family member A Bos taurus 45-48 1903399-7 1991 Gel permeation chromatography of radiolabeled hydrocarbons released from the rac1, rac2, and ralA proteins by reaction with Raney nickel catalyst indicated that unlike p21Hras, which was modified by a 15-carbon moiety, the rac and ralA translation products were modified by 20-carbon isoprenyl groups. Nickel 130-136 Rac family small GTPase 1 Homo sapiens 77-81 1903399-7 1991 Gel permeation chromatography of radiolabeled hydrocarbons released from the rac1, rac2, and ralA proteins by reaction with Raney nickel catalyst indicated that unlike p21Hras, which was modified by a 15-carbon moiety, the rac and ralA translation products were modified by 20-carbon isoprenyl groups. Nickel 130-136 Rac family small GTPase 2 Homo sapiens 83-87 1903399-7 1991 Gel permeation chromatography of radiolabeled hydrocarbons released from the rac1, rac2, and ralA proteins by reaction with Raney nickel catalyst indicated that unlike p21Hras, which was modified by a 15-carbon moiety, the rac and ralA translation products were modified by 20-carbon isoprenyl groups. Nickel 130-136 RAS like proto-oncogene A Homo sapiens 93-97 1903399-7 1991 Gel permeation chromatography of radiolabeled hydrocarbons released from the rac1, rac2, and ralA proteins by reaction with Raney nickel catalyst indicated that unlike p21Hras, which was modified by a 15-carbon moiety, the rac and ralA translation products were modified by 20-carbon isoprenyl groups. Nickel 130-136 Rac family small GTPase 1 Homo sapiens 77-80 2360638-2 1990 Intraperitoneal (ip) injection of chromium (Cr), managanese, and iron (Fe) caused a much greater increase in hepatic MT (10.2-, 9.0-, and 6.8-fold) compared with cobalt and nickel (2.5- and 2.9-fold); thus not all transition metals are effective. Nickel 173-179 metallothionein 4 Gallus gallus 117-119 1838243-2 1991 In this study of nickel dermatitis without autoeczematization and poison oak dermatitis with autoeczematization, it was noted that the process of autoeczematization was associated with the presence of CD8+ lymphocytes within the epidermis and the expression of HLA-DR antigens on epidermal keratinocytes. Nickel 17-23 CD8a molecule Homo sapiens 201-204 2058149-1 1991 NIS therapy (normoglycemic insulin substitution) is accepted by many juvenile diabetics with big expectations concerning a less restrictive diet and way of life. Nickel 0-3 insulin Homo sapiens 27-34 2260708-4 1990 Nickel (Ni2+, 50 microM) inhibited maximal T current (-65.6 +/- 5.9%) more than L current (-15.7 +/- 2.4%), and 10 microM cadmium (Cd2+) inhibited L current (-65.5 +/- 5.9%) without significant effect on T current (-8.7 +/- 8.1%). Nickel 0-6 CD2 molecule Homo sapiens 131-134 1699299-1 1990 This report describes the effects of low levels of copper, nickel and lead salts on the concentrations of alpha-fetoprotein (AFP) in the sera and amniotic fluid of pregnant Nylar mice. Nickel 59-65 alpha fetoprotein Mus musculus 106-123 1699299-5 1990 Low doses of nickel and copper were associated with elevated AFP levels in amniotic fluid in 15-17 day pregnant animals, while maternal serum AFP levels mostly remained unchanged. Nickel 13-19 alpha fetoprotein Mus musculus 61-64 1977209-4 1990 In the liver, nickel effects included increased LPO (by 30%), decreased CAT and GSH-Px activities (both by 15%), decreased GSH level (by 33%), decreased GSSG-R activity (by 10%) and decreased GST activity (by 35%); SOD, GGT, copper, and iron remained unchanged. Nickel 14-20 hematopoietic prostaglandin D synthase Rattus norvegicus 192-195 1977209-4 1990 In the liver, nickel effects included increased LPO (by 30%), decreased CAT and GSH-Px activities (both by 15%), decreased GSH level (by 33%), decreased GSSG-R activity (by 10%) and decreased GST activity (by 35%); SOD, GGT, copper, and iron remained unchanged. Nickel 14-20 gamma-glutamyltransferase 1 Rattus norvegicus 220-223 2363408-9 1990 It was concluded that the TTR should be reasonably higher than the oral temperature for clinical application of the shape-memory phenomenon of nickel-titanium alloys. Nickel 143-149 transthyretin Homo sapiens 26-29 2394987-2 1990 With the aid of an avidin-biotin, nickel-enhanced, immunohistochemical technique, CCK IR neuronal elements were found within the MPA and AH. Nickel 34-40 cholecystokinin Monodelphis domestica 82-85 2382268-0 1990 Effects of nickel on catalase activity in vitro and in vivo. Nickel 11-17 catalase Rattus norvegicus 21-29 2136230-0 1990 Cadmium, nickel, chromium and lead accumulate in human lymphocytes and interfere with PHA-induced proliferation. Nickel 9-15 lamin B receptor Homo sapiens 86-89 2136230-1 1990 The in vitro effect of five toxic metals (cadmium, lead, nickel, barium, chromium III and VI) on PHA-induced blastogenesis in human lymphocytes was investigated by [3H]-thymidine incorporation. Nickel 57-63 lamin B receptor Homo sapiens 97-100 2344475-0 1990 In vivo effects of nickel and cadmium in rats on lipid peroxidation and ceruloplasmin activity. Nickel 19-25 ceruloplasmin Rattus norvegicus 72-85 17815594-1 1990 Molecular dynamics simulations and atomic force microscopy are used to investigate the atomistic mechanisms of adhesion, contact formation, nanoindentation, separation, and fracture that occur when a nickel tip interacts with a gold surface. Nickel 200-206 TOR signaling pathway regulator Homo sapiens 207-210 17815594-2 1990 The theoretically predicted and experimentally measured hysteresis in the force versus tip-to-sample distance relationship, found upon approach and subsequent separation of the tip from the sample, is related to inelastic deformation of the sample surface characterized by adhesion of gold atoms to the nickel tip and formation of a connective neck of atoms. Nickel 303-309 TOR signaling pathway regulator Homo sapiens 87-90 17815594-2 1990 The theoretically predicted and experimentally measured hysteresis in the force versus tip-to-sample distance relationship, found upon approach and subsequent separation of the tip from the sample, is related to inelastic deformation of the sample surface characterized by adhesion of gold atoms to the nickel tip and formation of a connective neck of atoms. Nickel 303-309 TOR signaling pathway regulator Homo sapiens 177-180 17815594-2 1990 The theoretically predicted and experimentally measured hysteresis in the force versus tip-to-sample distance relationship, found upon approach and subsequent separation of the tip from the sample, is related to inelastic deformation of the sample surface characterized by adhesion of gold atoms to the nickel tip and formation of a connective neck of atoms. Nickel 303-309 TOR signaling pathway regulator Homo sapiens 177-180 17815594-3 1990 At small tipsample distances, mechanical instability causes the tip and surface to jump-to-contact, which in turn leads to adhesion-induced wetting of the nickel tip by gold atoms. Nickel 155-161 TOR signaling pathway regulator Homo sapiens 9-12 17815594-3 1990 At small tipsample distances, mechanical instability causes the tip and surface to jump-to-contact, which in turn leads to adhesion-induced wetting of the nickel tip by gold atoms. Nickel 155-161 TOR signaling pathway regulator Homo sapiens 64-67 2333957-0 1990 Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel. Nickel 84-90 angiotensinogen Homo sapiens 51-65 2356553-4 1990 Specific antibodies to nickel conjugated human serum albumin were present in four of the eight patients with sensitivity to cobalt conjugated human serum albumin but were absent from the serum of 60 unexposed asthmatic patients and 25 exposed symptom free workers. Nickel 23-29 albumin Homo sapiens 47-60 2356553-4 1990 Specific antibodies to nickel conjugated human serum albumin were present in four of the eight patients with sensitivity to cobalt conjugated human serum albumin but were absent from the serum of 60 unexposed asthmatic patients and 25 exposed symptom free workers. Nickel 23-29 albumin Homo sapiens 148-161 2322496-0 1990 HLA-A, B, C and DR antigens in nickel contact sensitivity. Nickel 31-37 major histocompatibility complex, class I, A Homo sapiens 0-18 2335085-3 1990 Nickel contents in 8 different domestic tap waters and another underground water sample were also measured by plasma scan. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 40-43 2335085-4 1990 Nickel contents in the patient"s underground water were 9 times higher on average than those in domestic tap water. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 105-108 2323205-5 1990 Finally, in 5 cases out of 6, the subjects allergic to MCI also tested positively for nickel, while only 15% of the total of 540 subjects tested with MCI had a nickel allergy confirmed by patch tests. Nickel 86-92 multiciliate differentiation and DNA synthesis associated cell cycle protein Homo sapiens 55-58 2333414-3 1990 Nickel chloride and nickel-albumin showed an initial rapid binding to human trophoblast cells reaching a quasi-steady state after 30 min. Nickel 20-26 albumin Homo sapiens 27-34 2333414-4 1990 Albumin, however, reduced the binding of nickel to the cells. Nickel 41-47 albumin Homo sapiens 0-7 2346498-2 1990 The administration of nickel to mice resulted in an inhibition in the activity of free radical reductase, and enhanced lipid peroxidation and the activity of glutathione S-transferase in a dose dependent manner. Nickel 22-28 hematopoietic prostaglandin D synthase Mus musculus 158-183 2346498-3 1990 The pretreatment of cyclam, a known specific chelator of nickel restored free radical reductase and glutathione S-transferase activities and alleviated nickel mediated enhancement of lipid peroxidation. Nickel 57-63 hematopoietic prostaglandin D synthase Mus musculus 100-125 2346498-4 1990 Our results indicate that nickel-mediated inhibition in free radical reductase activity and activation of glutathione S-transferase may be due to the interaction of nickel with sensitive-SH groups located on these proteins. Nickel 26-32 hematopoietic prostaglandin D synthase Mus musculus 106-131 2346498-4 1990 Our results indicate that nickel-mediated inhibition in free radical reductase activity and activation of glutathione S-transferase may be due to the interaction of nickel with sensitive-SH groups located on these proteins. Nickel 165-171 hematopoietic prostaglandin D synthase Mus musculus 106-131 34889493-2 2022 Treatment of gem-difluoroalkenes with racemic benzyl electrophiles in the presence of a chiral nickel complex using B 2 pin 2 as a stoichiometric reductant allows the construction of a C(sp 2 )-C(sp 3 ) bond under mild conditions, affording a broad range of monofluoroalkenes bearing stereogenic allylic centers. Nickel 95-101 telomeric repeat binding factor 1 Homo sapiens 120-125 31881266-4 2020 Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta). Nickel 28-34 interleukin 1 beta Homo sapiens 95-112 31881266-4 2020 Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta). Nickel 28-34 interleukin 1 beta Homo sapiens 114-122 18338891-1 2008 The nickel-catalyzed enantioselective addition of allylboronic acid pinacol ester, allylB(pin), is described. Nickel 4-10 dynein light chain LC8-type 1 Homo sapiens 68-71 34823954-0 2022 Metallic technetium sequestration in nickel core/shell microstructure during Fe(OH)2 transformation with Ni doping. Nickel 37-43 general transcription factor IIE subunit 1 Homo sapiens 77-84 34844349-1 2022 Herein, novel magnetic nickel incorporated carbon nanofibers (Ni@CNF) were successfully synthesized via electrostatic spinning method for sulfadiazine (SDZ) adsorption. Nickel 23-29 NPHS1 adhesion molecule, nephrin Homo sapiens 65-68 34889493-2 2022 Treatment of gem-difluoroalkenes with racemic benzyl electrophiles in the presence of a chiral nickel complex using B 2 pin 2 as a stoichiometric reductant allows the construction of a C(sp 2 )-C(sp 3 ) bond under mild conditions, affording a broad range of monofluoroalkenes bearing stereogenic allylic centers. Nickel 95-101 Sp2 transcription factor Homo sapiens 185-191 34114143-2 2022 This study aims to remove and recover copper and nickel ions from synthetic PCB wastewater using a fluidized-bed homogeneous granulation process (FBHGP). Nickel 49-55 pyruvate carboxylase Homo sapiens 76-79 34428683-2 2022 Here, we obtained a three-dimensional Co(OH)2 nanosheet with high surface area on nickel foam (Co(OH)2/NF) via conventional hydrothermal. Nickel 82-88 neurofascin Homo sapiens 103-105 34546526-3 2022 The kinetic release experiment of the metal ion concentrations (nickel, chromium, titanium, iron, and copper) in the saliva uptakes follows a pseudo-second-order kinetic model; the release rate of metal ions was in series Fe2+ > Ti2+ > Ni2+ > Cu2+ > Cr3+, and the highest saliva pH and flow rate were detected after 1 month for fixed orthodontics appliance was (7.16 +- 0.55) and (0.88 +- 0.55) respectively. Nickel 64-70 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 250-253 34500168-2 2022 Herein, in situ growth of Molybdenum-doped amorphous cobalt acid nickel nanoneedles on Ni foam (Mo-NiCo2O4/NF) has been successfully synthesized by a simple hydrothermal-annealing strategy. Nickel 65-71 neurofascin Homo sapiens 107-109 34500169-2 2022 Herein, ultrathin rhodium-iridium nanosheets were facilely in-situ grown on nickel foam (RhIr NSs/NF) by a one-pot aqueous strategy at room temperature. Nickel 76-82 neurofascin Homo sapiens 98-100 34727382-0 2022 Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter. Nickel 44-50 cadherin 1 Homo sapiens 30-40 34873760-3 2022 Herein, a series of ternary NiCoFe LDHs were successfully fabricated on nickel foam (NF) via a simple electrodeposition method. Nickel 72-78 neurofascin Homo sapiens 85-87 34727382-3 2022 Our earlier studies showed that nickel, a ubiquitous environmental toxicant, induced EMT by persistently downregulating E-cadherin expression in human lung epithelial cells and that the EMT remained irreversible postexposure. Nickel 32-38 cadherin 1 Homo sapiens 120-130 34727382-4 2022 However, the molecular basis of persistent E-cadherin downregulation by nickel exposure is not understood. Nickel 72-78 cadherin 1 Homo sapiens 43-53 34727382-6 2022 Nickel exposure caused a loss of Sp1 binding at the CDH1 promoter, resulting in its downregulation and EMT induction. Nickel 0-6 cadherin 1 Homo sapiens 52-56 34727382-8 2022 ZEB1, an EMT master regulator persistently upregulated by nickel exposure, is a negative regulator of CDH1. Nickel 58-64 zinc finger E-box binding homeobox 1 Homo sapiens 0-4 34727382-8 2022 ZEB1, an EMT master regulator persistently upregulated by nickel exposure, is a negative regulator of CDH1. Nickel 58-64 cadherin 1 Homo sapiens 102-106 34726504-13 2022 Conversely, TAZ nuclear retention was promoted by TGFbeta, a potent NIS repressor, and TAZ silencing markedly relieved the TGFbeta-induced inhibition of the symporter. Nickel 68-71 tafazzin, phospholipid-lysophospholipid transacylase Mus musculus 12-15 34726504-13 2022 Conversely, TAZ nuclear retention was promoted by TGFbeta, a potent NIS repressor, and TAZ silencing markedly relieved the TGFbeta-induced inhibition of the symporter. Nickel 68-71 transforming growth factor alpha Mus musculus 50-57 34957676-3 2022 The reaction also represents the enantioselective construction of carbon(sp 3 )-silicon bonds with nickel catalysis, which provides an atom- and step-economical synthesis route of high-value optically active alpha-difluoromethylsilanes. Nickel 99-105 Sp3 transcription factor Homo sapiens 73-77 34948007-3 2021 We bring up the problem of ITC results of nickel binding to the Hpn-like protein being not always compatible with those from potentiometry and MS regarding the stoichiometry and affinity. Nickel 42-48 hepsin Homo sapiens 64-67 34921706-3 2022 The spin-state modulation enables enhanced nickel-oxygen covalency in Ni III -NCF, which facilitates electron exchange between the Ni sites and oxygen adsorbates and accelerates the oxygen redox kinetics. Nickel 43-49 spindlin 1 Homo sapiens 4-8 34850803-1 2021 The structural collapse and surface chemical degradation of nickel-rich layered oxide cathodes (NCM) of lithium-ion batteries during operation, which result in severe capacity attenuation, are the major challenges that hinder their commercial development. Nickel 60-66 CWC22 spliceosome associated protein homolog Homo sapiens 96-99 34938369-7 2021 The Panel notes that the NF contains nickel at concentrations that may increase the risk of flare-up reactions in nickel-sensitised young individuals up to 10 years of age. Nickel 37-43 neurofascin Homo sapiens 25-27 34793680-2 2021 Herein, we report a new catalytic blueprint that merges the modularity of nickel catalysis for bond formation with the ability to enable a rather elusive 1,4-hydride shift at arene sp2 C-H sites, thus allowing access to ipso/ortho-difunctionalized arenes from readily available aryl halides under mild conditions and exquisite selectivity profile. Nickel 74-80 Sp2 transcription factor Homo sapiens 181-184 34948007-0 2021 A Comparative Study on Nickel Binding to Hpn-like Polypeptides from Two Helicobacter pylori Strains. Nickel 23-29 hepsin Homo sapiens 41-44 34767360-1 2021 We report a method to activate alpha-3 amines for deaminative arylation via condensation with an electron-rich aldehyde and merge this reactivity with nickel metallaphotoredox to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. Nickel 152-158 immunoglobulin kappa variable 2D-28 Homo sapiens 31-38 34813330-0 2021 Spontaneous Strain Buffer Enables Superior Cycling Stability in Single-Crystal Nickel-Rich NCM Cathode. Nickel 79-85 CWC22 spliceosome associated protein homolog Homo sapiens 91-94 34816851-2 2021 Here, a mild hydrothermal-electrodeposition two-step route is designed for the preparation of Ce-doped Ni-S@NiMoO4 micropillar composites on nickel foam (CeNiS@NiMoO4/NF). Nickel 141-147 solute carrier family 5 member 5 Homo sapiens 103-107 34816851-2 2021 Here, a mild hydrothermal-electrodeposition two-step route is designed for the preparation of Ce-doped Ni-S@NiMoO4 micropillar composites on nickel foam (CeNiS@NiMoO4/NF). Nickel 141-147 neurofascin Homo sapiens 167-169 34854554-3 2022 Accordingly, ruthenium modified nickel diselenide nanosheet arrays are designed and construct on nickel foam (Ru-NiSe2 /NF). Nickel 97-103 neurofascin Homo sapiens 120-122 34747430-6 2021 Even in the pushing conditions (200 mum for the cathode layer and 20 mum for the solid electrolyte separator), high-nickel ternary (NCM) cathodes hardly meet the expectation of the battery development roadmap in terms of gravimetric energy density at a cell level, while lithium- and manganese-rich ternary (LM-NCM) and sulfur cathodes are feasible. Nickel 116-122 CWC22 spliceosome associated protein homolog Homo sapiens 132-135 34757347-2 2021 Here, we spun nanoparticles of nickel-manganese oxides along with carbon nanotubes into carbon nanofibers and engineered a 3D networked Ni-Mn oxides/CNT@CNF free-standing membrane for flexible supercapacitor applications. Nickel 31-37 NPHS1 adhesion molecule, nephrin Homo sapiens 153-156 34789290-0 2021 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1alpha/miR-210/Rad52 pathway. Nickel 0-6 hypoxia inducible factor 1, alpha subunit Mus musculus 105-115 34789290-0 2021 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1alpha/miR-210/Rad52 pathway. Nickel 0-6 microRNA 210 Mus musculus 116-123 34789290-0 2021 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1alpha/miR-210/Rad52 pathway. Nickel 0-6 RAD52 homolog, DNA repair protein Mus musculus 124-129 34841177-3 2021 In this study, the deposition of crystalline flowerlike 2D nanosheets of nickel molybdate (NiMoO4) directly on nickel foam (NF) through an aerosol-assisted chemical vapor deposition process is reported. Nickel 111-117 neurofascin Homo sapiens 124-126 34689562-2 2021 Herein, a 2D heterostructure is synthesized by anchoring nickel nanoparticle-decorated black phosphorus (BP) nanosheets to graphitic carbon nitride (CN) nanosheets (CN/BP@Ni). Nickel 57-63 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 105-107 34689562-2 2021 Herein, a 2D heterostructure is synthesized by anchoring nickel nanoparticle-decorated black phosphorus (BP) nanosheets to graphitic carbon nitride (CN) nanosheets (CN/BP@Ni). Nickel 57-63 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 149-151 34689562-2 2021 Herein, a 2D heterostructure is synthesized by anchoring nickel nanoparticle-decorated black phosphorus (BP) nanosheets to graphitic carbon nitride (CN) nanosheets (CN/BP@Ni). Nickel 57-63 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 165-170 34416372-6 2021 Recent studies have demonstrated that some heavy metal carcinogens, including arsenic and nickel, can induce the loss of SLBP and the gain of polyadenylation of canonical histone mRNAs. Nickel 90-96 stem-loop binding protein Homo sapiens 121-125 34571076-4 2021 The accurate role of ANGPTL4 and its methylation status caused by nickel in the lung carcinogenesis is not fully explored yet. Nickel 66-72 angiopoietin like 4 Homo sapiens 21-28 34571076-12 2021 We also showed that nickel-induced TET1 was stimulated by HIF-1alpha. Nickel 20-26 tet methylcytosine dioxygenase 1 Homo sapiens 35-39 34571076-12 2021 We also showed that nickel-induced TET1 was stimulated by HIF-1alpha. Nickel 20-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 58-68 34571076-13 2021 Our work established ANGPTL4 as a potential oncogene that contributes to lung cancer progression and nickel-elicited carcinogenesis. Nickel 101-107 angiopoietin like 4 Homo sapiens 21-28 34643376-10 2021 In general, the presented methodology provides a simple and convenient setup for the synthesis and carbon isotope labeling of aliphatic carboxylates, while providing new insights about the reactivity of the N2N nickel pincer complex applied. Nickel 211-217 notch 2 N-terminal like A Homo sapiens 207-210 34352574-0 2021 Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney. Nickel 0-6 thymoma viral proto-oncogene 1 Mus musculus 34-37 34734701-4 2021 The similar increasing trend of Ni/V ratios (from <0.4 to >2.0) in both ambient measurement and heavy fuel oil samples suggests that the DECA and IMO 2020 regulations effectively reduced the ambient V. However, nickel content is still enriched in the in-use desulfurized residual oils and ship-emitted particles in coastal China. Nickel 211-217 inositol polyphosphate-5-phosphatase D Homo sapiens 289-293 34760283-2 2021 Nickel hypersensitivity has been reported in up to 13% of the general population and there is a concern that nickel hypersensitivity might adversely affect the outcome of total hip replacement (THR). Nickel 109-115 hedgehog interacting protein Homo sapiens 177-180 34174665-5 2021 Soil parent materials, pH, organic matter, and clay particle size were the key factors influencing accumulation of arsenic, chromium, and nickel. Nickel 138-144 phenylalanine hydroxylase Homo sapiens 23-25 34352574-0 2021 Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney. Nickel 0-6 mechanistic target of rapamycin kinase Mus musculus 38-42 34508780-4 2021 Herein, we report the first crystal structure of human ADO at a resolution of 1.78 A with a nickel-bound metal center. Nickel 92-98 2-aminoethanethiol dioxygenase Homo sapiens 55-58 34582691-0 2021 Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- and C3-Borylated Indolines. Nickel 0-6 complement C2 Homo sapiens 82-92 34576685-4 2021 The results of the study show that the mechanical properties of the nickel deposits electrodeposited onto Q235A are optimized when plating at a current density of 3 A/dm2, a bath temperature of 45 C, and a pH of 3.5. Nickel 68-74 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 167-170 34576685-5 2021 The nickel-plated layer has a minimum grain size of 34.8 nm, a microhardness of 3.86 GPa, a modulus of elasticity of 238 GPa, and a surface roughness Ra of 0.182 mum. Nickel 4-10 glycophorin A (MNS blood group) Homo sapiens 85-88 34576685-5 2021 The nickel-plated layer has a minimum grain size of 34.8 nm, a microhardness of 3.86 GPa, a modulus of elasticity of 238 GPa, and a surface roughness Ra of 0.182 mum. Nickel 4-10 glycophorin A (MNS blood group) Homo sapiens 121-124 34134382-9 2021 Nickel exposure affects the incidence of initial shockable rhythm (IRR 0.92; p = 0.01) and effectiveness of CPR (IRR 0.94; p = 0.003). Nickel 0-6 insulin receptor related receptor Homo sapiens 67-70 34134382-9 2021 Nickel exposure affects the incidence of initial shockable rhythm (IRR 0.92; p = 0.01) and effectiveness of CPR (IRR 0.94; p = 0.003). Nickel 0-6 insulin receptor related receptor Homo sapiens 113-116 34528958-1 2021 Herein, a highly regioselective alkylation of propargylic carbonates for trisubstituted allenes with alkyl 1,4-dihydropyridine derivatives (1,4-DHPs) is developed via a photoredox/nickel dual-catalyzed process, which represents the first direct approach to access alkylated allene products without alkyl organometallic reagents. Nickel 180-186 deoxyhypusine synthase Homo sapiens 144-148 34519748-2 2021 This study proposes an effective strategy for the construction of Fe doped CoP nanosheet arrays wrapped by graphene (F0.25CP-G) on nickel foam as an efficient electrocatalyst for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). Nickel 131-137 caspase recruitment domain family member 16 Homo sapiens 75-78 34229394-2 2021 Towards this endeavor, nanoporous SnS2 film electrodes deposited by a solution process on nickel foam demonstrate a promising electrocatalytic activity towards generation of H2 gas at cathode while the anodic reaction leads to the decomposition of urea-waste at the rate of 10 mA cm-2 in 1 M KOH with a lower cell-potential of 1.38 V vs RHE. Nickel 90-96 sodium voltage-gated channel alpha subunit 11 Homo sapiens 34-38 34410708-0 2021 Nickel-Catalyzed Enantioselective Synthesis of Pre-Differentiated Homoallylic syn- or anti-1,2-Diols from Aldehydes and Dienol Ethers. Nickel 0-6 synemin Homo sapiens 78-81 34109987-0 2021 RUNX2/miR-31/SATB2 pathway in nickel-induced BEAS-2B cell transformation. Nickel 30-36 RUNX family transcription factor 2 Homo sapiens 0-5 34514258-1 2021 To improve the condensed-phase reaction rate of epsilon-CL-20, polydopamine (PDA)-nickel complex-coated multiwalled carbon nanotubes (CNTs) have been prepared and used as combustion catalysts. Nickel 82-88 epithelial membrane protein 1 Homo sapiens 56-61 34302157-2 2021 A series of P-Co3O4@NiCo-LDH/NF materials was firstly successfully synthesized by a hydrothermal method, high temperature calcination and an electrochemical deposition approach when sodium hypophosphite was used as the source of P and Ni(NO3)2 6H2O as the source of nickel and introduced cobalt at the same time. Nickel 266-272 neurofascin Homo sapiens 29-31 34313283-2 2021 Herein, a sulfidation of nickel foam (Ni2S3/NF) was attempted via a hydrothermal method, achieving high selectivity and efficiency for HMF oxidation. Nickel 25-31 neurofascin Homo sapiens 44-46 34451746-6 2021 The objective of this research was to investigate the effects of leaf shape (curly leaf: CRL) on cottonseed B, Cu, Fe, Mn, Ni (nickel), and Zn in two near-isogenic cotton lines differing in leaf shape (DP 5690 wild-type with normal leaves and DP 5690 CRL). Nickel 127-133 interleukin 31 receptor A Homo sapiens 89-92 34397048-2 2021 Here a novel and cost-effective nickel catalyzed ortho-CAr-H glycosylation reaction with high regioselectivity and excellent alpha-selectivity is described. Nickel 32-38 CXADR pseudogene 1 Homo sapiens 55-58 34485240-5 2021 Results showed that tert-octylsalicylaldoxime with a new structure exhibited excellent extraction ability and selectivity for Cu(II) and can be successfully used to recover Cu from copper-nickel alloy electroplating wastewater. Nickel 188-194 telomerase reverse transcriptase Homo sapiens 20-24 34362891-5 2021 By the Paleoproterozoic, they became genetically capable of using iron, nickel, and manganese as cofactors (FeSOD, NiSOD, and MnSOD respectively). Nickel 72-78 superoxide dismutase 2 Homo sapiens 126-131 34283575-2 2021 Herein, heterostructured nickel foam-supported cobalt carbonate hydroxide nanoarrays embellished with NiCoSx nanoflakes (NiCoSx@CoCH NAs/NF) are designed via room-temperature sulfurization, which can drive 10 and 1000 mA cm-2 at low overpotentials of 55 and 438 mV for HER and exhibit impressive long-term stability at the industrial-level current density. Nickel 25-31 cochlin Homo sapiens 128-132 34126150-0 2021 Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model. Nickel 70-76 galactosidase beta 1 Homo sapiens 116-134 34126150-1 2021 The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model. Nickel 102-108 galactosidase beta 1 Homo sapiens 250-268 34126150-9 2021 The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes. Nickel 57-63 galactosidase beta 1 Homo sapiens 129-147 33714351-0 2021 Effect of the Electroless Nickel, Electroless Palladium, and Immersion Gold Multilayer as a Diffusion Barrier on the Bonding Strength of BiTe-Based Thermoelectric Modules. Nickel 26-32 centrosomal protein 70 Homo sapiens 137-141 33714351-2 2021 In this study, the electrochemical deposition of multi-layers, i.e., electroless nickel/electroless palladium/immersion gold (ENEPIG) was explored to enhance the bonding strength of BiTe materials with Cu electrodes. Nickel 81-87 centrosomal protein 70 Homo sapiens 182-186 34109987-0 2021 RUNX2/miR-31/SATB2 pathway in nickel-induced BEAS-2B cell transformation. Nickel 30-36 microRNA 31 Homo sapiens 6-12 34109987-0 2021 RUNX2/miR-31/SATB2 pathway in nickel-induced BEAS-2B cell transformation. Nickel 30-36 SATB homeobox 2 Homo sapiens 13-18 34336009-5 2021 Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. Nickel 162-168 albumin Homo sapiens 42-49 34171644-3 2021 Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF. Nickel 67-73 caspase recruitment domain family member 16 Homo sapiens 44-47 34171644-3 2021 Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF. Nickel 67-73 caspase recruitment domain family member 16 Homo sapiens 83-86 34171644-3 2021 Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF. Nickel 67-73 S100 calcium binding protein A9 Homo sapiens 91-94 34171644-3 2021 Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF. Nickel 67-73 caspase recruitment domain family member 16 Homo sapiens 153-156 34171644-3 2021 Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF. Nickel 67-73 S100 calcium binding protein A9 Homo sapiens 191-194 34321467-4 2021 Herein, we report a single-atomic-site ruthenium stabilized on defective nickel-iron layered double hydroxide nanosheets (Ru1/D-NiFe LDH). Nickel 73-79 Scm like with four mbt domains 1 Homo sapiens 122-125 34180473-1 2021 We describe the reactivity of the hypersilyl-functionalized Zintl cluster salt K(Ge9(Hyp)3) towards the nickel reagents Ni(COD)2 and Ni(Cp)2, which gives rise to markedly different complexes. Nickel 104-110 COD2 Homo sapiens 120-128 34180473-1 2021 We describe the reactivity of the hypersilyl-functionalized Zintl cluster salt K(Ge9(Hyp)3) towards the nickel reagents Ni(COD)2 and Ni(Cp)2, which gives rise to markedly different complexes. Nickel 104-110 ceruloplasmin Homo sapiens 133-140 34361231-3 2021 Here, we first prepared Fe-MOF nanosheet arrays on nickel foam via rare-earth erbium doping (Er0.4 Fe-MOF/NF) and applied them as OER electrocatalysts. Nickel 51-57 neurofascin Homo sapiens 106-108 34170102-3 2021 We developed a simple method to prepare a nickel foam (NF)-based monolith electrode with a NiO nanosheet array structure as an efficient electrocatalyst toward the oxidation of methanol to produce formate. Nickel 42-48 neurofascin Homo sapiens 55-57 34143621-4 2021 Further, the reluctance of Ni(II) to oxidize into Ni(III) in comparison to the proneness of Co(II) to Co(III) oxidation was found to have a profound effect on the final product composition, as a deficiency of ions in the III oxidation state under nickel-rich reaction conditions hindered the formation of a monoclinic "Co3Se4-type" phase. Nickel 247-253 mitochondrially encoded cytochrome c oxidase III Homo sapiens 221-224 34712407-2 2021 This study aimed to compare the cyclic fatigue resistance of ProTaper Next, Hyflex CM, 2Shape, and TF-Adaptive nickel-titanium endodontic file systems with various alloy properties and production methods and investigate the fractured cross-sectional surface of files due to cyclic fatigue by scanning electron microscopy (SEM). Nickel 111-117 coagulation factor III, tissue factor Homo sapiens 99-101 34109953-3 2021 The Co-N-Ni3S2/NF is successfully synthesized for the first time by a one-step hydrothermal method, wherein nickel foam, thioacetamide and Co(NO3)2 6H2O are used as the nickel source, sulfur source, nitrogen source and cobalt source. Nickel 108-114 neurofascin Homo sapiens 9-17 34109953-3 2021 The Co-N-Ni3S2/NF is successfully synthesized for the first time by a one-step hydrothermal method, wherein nickel foam, thioacetamide and Co(NO3)2 6H2O are used as the nickel source, sulfur source, nitrogen source and cobalt source. Nickel 169-175 neurofascin Homo sapiens 9-17 34183691-1 2021 Present work comprehensively investigated the electrochemical response of Nickel-2 Aminoterephthalic acid Metal-Organic Framework (NiNH2BDC) and its reduced graphitic carbon (rGO) based hybrids for methanol (CH3OH) oxidation reaction (MOR) in an alkaline environment. Nickel 74-80 opioid receptor mu 1 Homo sapiens 235-238 34249892-4 2021 Herein, we presented a nickel ion capture strategy by the combination of zwitterionic hydrogels as anti-bacteria layers and carbon disulfide (CS2) components as nickel-catchers (Ni-catchers). Nickel 23-29 chorionic somatomammotropin hormone 2 Homo sapiens 142-145 34249892-4 2021 Herein, we presented a nickel ion capture strategy by the combination of zwitterionic hydrogels as anti-bacteria layers and carbon disulfide (CS2) components as nickel-catchers (Ni-catchers). Nickel 161-167 chorionic somatomammotropin hormone 2 Homo sapiens 142-145 34110779-1 2021 A series of orientation-adjustable metal-organic framework (MOF) nanorods, CoFe(dobpdc)-I to CoFe(dobpdc)-III (dobpdc = 4,4"-dihydroxybiphenyl-3,3"-dicarboxylate), is developed on a 3D nickel foam (NF) template. Nickel 185-191 neurofascin Homo sapiens 198-200 35614111-3 2022 Here, we perform anodic electrochemical oxidation of Ni-metalloids (NiPx, NiSx, and NiSex) to in-situ construct different oxyanion-coordinated amorphous nickel oxyhydroxides (NiOOH-TOx), among which NiOOH-POx shows optimal local coordination environment and boosts electrocatalytic activity of Ni sites towards selective oxidation of methanol to formate. Nickel 153-159 thymocyte selection associated high mobility group box Homo sapiens 181-184 34135394-7 2021 On the other hand, metals such as nickel and zinc promote miR-526B but not miR-520G, to result in the suppression of MAGEA mRNA expression, and evoke cell death through mitochondrial membrane depolarization. Nickel 34-40 microRNA 526b Homo sapiens 58-66 34198732-0 2021 Magnetic-Field-Orientation Dependent Thermal Entanglement of a Spin-1 Heisenberg Dimer: The Case Study of Dinuclear Nickel Complex with an Uniaxial Single-Ion Anisotropy. Nickel 116-122 spindlin 1 Homo sapiens 63-69 34198732-7 2021 The homodinuclear nickel complex (Ni2(Medpt)2(mu-ox)(H2O)2)(ClO4)2 2H2O provides a suitable experimental platform of the antiferromagnetic spin-1 Heisenberg dimer, which allowed us to estimate a strength of the bipartite entanglement between two exchange-coupled Ni2+ magnetic ions on the grounds of the interaction constants reported previously from the fitting procedure of the magnetization data. Nickel 18-24 spindlin 1 Homo sapiens 139-145 34115630-1 2021 Degradation activity of plasma catalysis between dielectric barrier discharge (DBD) and carbon nanotubes-graphene-nickel foam (CNTs-G-Nif) has been studied in treatment of dye wastewater. Nickel 114-120 S100 calcium binding protein A9 Homo sapiens 134-137 34068879-2 2021 Amino-terminal copper and nickel binding motifs (ATCUN) identified in truncated Abeta sequences starting with Phe4 show very high affinity for copper(II) ions. Nickel 26-32 amyloid beta precursor protein Homo sapiens 80-85 34065930-2 2021 The calculated sensitivities for these microsensors are 1110 and 2080 muA mM-1 cm-2 for copper and nickel, respectively. Nickel 99-105 Mix1 homeobox-like 1 (Xenopus laevis) Mus musculus 74-83 34163834-1 2021 In this work, spectroelectrochemical techniques are employed to analyse the catalytic water oxidation performance of a series of three nickel/iron oxyhydroxide electrocatalysts deposited on FTO and BiVO4, at neutral pH. Nickel 135-141 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 190-193 34150240-7 2021 The mean blood levels of lead, antimony, and nickel were higher in SA than ongoing pregnancy; however, this difference was not statistically significant. Nickel 45-51 acyl-CoA synthetase medium chain family member 3 Homo sapiens 67-69 34163637-0 2021 Single-atom nickel terminating sp2 and sp3 nitride in polymeric carbon nitride for visible-light photocatalytic overall water splitting. Nickel 12-18 Sp2 transcription factor Homo sapiens 31-34 34163637-0 2021 Single-atom nickel terminating sp2 and sp3 nitride in polymeric carbon nitride for visible-light photocatalytic overall water splitting. Nickel 12-18 Sp3 transcription factor Homo sapiens 39-42 35452927-3 2022 Nickel-cobalt sulfide nanoparticles are hydrothermally grown on electrospun carbon nanofibers (CNF@NiCoS-650). Nickel 0-6 NPHS1 adhesion molecule, nephrin Homo sapiens 95-98 35550510-0 2022 A highly sensitive photoelectrochemical biosensor for CEA analysis based on hollow NiS@NiO/TiO2 composite with typal p-n heterostructure. Nickel 83-86 CEA cell adhesion molecule 3 Homo sapiens 54-57 35366442-3 2022 MnFe2O4-C@Al2O3 was characterized and applied in the removal of total nickel (TNi) and organic contaminants from actual ENPE, using a coupled system of HCO combined with a magnetic dithiocarbamate chelating resin (MnFe2O4-C@Al2O3/O3-MDCR). Nickel 70-76 platelet activating factor acetylhydrolase 1b regulatory subunit 1 Homo sapiens 233-237 35537548-0 2022 Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation. Nickel 66-72 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 86-90 35537548-0 2022 Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation. Nickel 66-72 NLR family, pyrin domain containing 3 Mus musculus 97-102 35537548-0 2022 Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation. Nickel 66-72 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 107-111 35537548-0 2022 Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation. Nickel 66-72 transforming growth factor, beta 1 Mus musculus 112-121 35325862-2 2022 Herein, we report an MXene nano-Co3O4 co-catalyst enriched with oxygen vacancies (Ov) and steadily fixed in nickel foam (NF) plates, which is used as an efficient and stable PMS activator for the removal of 1,4-dioxane (1,4-D). Nickel 108-114 neurofascin Homo sapiens 121-123 35622073-3 2022 Herein, this work reports a simple and scalable immersion synthetic strategy to deposit reduced graphene oxide (rGO) nanosheets integrated with Ni-Fe-based hydroxide nanocatalysts on nickel foam (NF) at room temperature. Nickel 183-189 neurofascin Homo sapiens 196-198 35178720-0 2022 Decreased serum level of suprabasin in patients with nickel allergy. Nickel 53-59 suprabasin Homo sapiens 25-35 35460208-1 2022 Here, a strategy to regulate the electron density distribution by integrating NiFe layered double hydroxides (NiFe-LDH) nanosheets with Co3 O4 nanowires to construct the NiFe-LDH/Co3 O4 p-n heterojunction supported on nickel foam (NiFe-LDH/Co3 O4 /NF) for electrocatalytic oxygen evolution reaction (OER) is proposed. Nickel 218-224 neurofascin Homo sapiens 248-250 35623502-0 2022 Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPbeta. Nickel 89-95 interleukin 6 Homo sapiens 25-29 35623502-0 2022 Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPbeta. Nickel 89-95 signal transducer and activator of transcription 3 Homo sapiens 148-153 35623502-0 2022 Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPbeta. Nickel 89-95 CCAAT enhancer binding protein alpha Homo sapiens 158-167 35623502-1 2022 We previously reported that delivery of nickel nanoparticles (NiNPs) and bacterial lipopolysaccharide (LPS) into the lungs of mice synergistically increased IL-6 production and inflammation, and male mice were more susceptible than female mice. Nickel 40-46 interleukin 6 Mus musculus 157-161 35527707-1 2022 Nickel-zinc iron oxide (NZF) was introduced into a polyaniline (PANI) matrix by an in situ chemical oxidation polymerization approach. Nickel 0-6 PHD finger protein 20 Homo sapiens 24-27 35522204-0 2022 Divergent Regioselective Csp2-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis. Nickel 82-88 regulator of calcineurin 2 Homo sapiens 25-29 35322915-0 2022 Nickel-catalyzed Csp2-OMe functionalization for chemoselective aromatic homologation en route to nanographenes. Nickel 0-6 regulator of calcineurin 2 Homo sapiens 17-21 35590444-3 2022 Herein, we design a hierarchical nanowire array of metal sulfides heterostructure on nickel foam (FeCoNiS x /NF) as a novel type of hybrid electrocatalyst for overall water splitting. Nickel 85-91 neurofascin Homo sapiens 109-111 35474514-0 2022 Nickel penetration into stratum corneum in FLG null carriers-A human experimental study. Nickel 0-6 filaggrin Homo sapiens 43-46 35556134-5 2022 Metallochaperones and accessory proteins (SlyD, HypA, HypB, UreD, UreE, UreF, and UreG) form specific protein complexes to allow the transfer of nickel from one protein to another without releasing the toxic metal into the cytoplasm. Nickel 145-151 pre-mRNA processing factor 40 homolog A Homo sapiens 48-52 35556134-5 2022 Metallochaperones and accessory proteins (SlyD, HypA, HypB, UreD, UreE, UreF, and UreG) form specific protein complexes to allow the transfer of nickel from one protein to another without releasing the toxic metal into the cytoplasm. Nickel 145-151 SET domain containing 2, histone lysine methyltransferase Homo sapiens 54-58 35556134-6 2022 The role of SlyD is not fully understood, but it can interact with and transfer its nickel to HypB. Nickel 84-90 SET domain containing 2, histone lysine methyltransferase Homo sapiens 94-98 35556134-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 39-45 SET domain containing 2, histone lysine methyltransferase Homo sapiens 66-70 35556134-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 39-45 pre-mRNA processing factor 40 homolog A Homo sapiens 74-78 35556134-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 107-113 SET domain containing 2, histone lysine methyltransferase Homo sapiens 66-70 35556134-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 107-113 pre-mRNA processing factor 40 homolog A Homo sapiens 74-78 35556134-8 2022 In Helicobacter pylori, the urease maturation pathway receives its nickel from HypA of the hydrogenase maturation pathway via the formation of a HypA/UreE2 complex. Nickel 67-73 pre-mRNA processing factor 40 homolog A Homo sapiens 79-83 35556134-8 2022 In Helicobacter pylori, the urease maturation pathway receives its nickel from HypA of the hydrogenase maturation pathway via the formation of a HypA/UreE2 complex. Nickel 67-73 pre-mRNA processing factor 40 homolog A Homo sapiens 145-149 35628102-2 2022 Herein, bifunctional electrocatalysts of the three-dimensional (3D) cobalt-nickel phosphide nanoarray in situ grown on nickel foams (CoNiP NA/NF) were synthesized through a facile hydrothermal method followed by phosphorization. Nickel 119-125 neurofascin Homo sapiens 133-144 35465672-0 2022 Morphology-Dependent Electrocatalytic Performance of a Two-Dimensional Nickel-Iron MOF for Oxygen Evolution Reaction. Nickel 71-77 lysine acetyltransferase 8 Homo sapiens 83-86 35567075-0 2022 Fabrication of a Nickel Ferrite/Nanocellulose-Based Nanocomposite as an Active Sensing Material for the Detection of Chlorine Gas. Nickel 17-23 gastrin Homo sapiens 126-129 35567075-10 2022 Gas sensing properties were determined by evaluating sensitivity as a function of various regulating factors, such as the amount of nickel ferrite, gas concentration, repeatability, and reusability. Nickel 132-138 gastrin Homo sapiens 0-3 35508890-8 2022 The results showed that the risk of carcinogenicity due to exposure to nickel, manganese in both gas and arc welding, and cadmium in gas welding was higher than standard level (hazard quotient (HQ) more than 1). Nickel 71-77 gastrin Homo sapiens 97-100 35508890-9 2022 Cancer risk due to exposure to nickel in both gas and arc welding was probable (1 x 10-6 < cancer risk (CR) < 1 x 10-4). Nickel 31-37 gastrin Homo sapiens 46-49 35437987-0 2022 Reactions of Tri-tert-Butylphosphatetrahedrane as a Spring-Loaded Phosphinidene Synthon Featuring Nickel-Catalyzed Transfer to Unactivated Alkenes. Nickel 98-104 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 13-16 35446576-3 2022 (Ir(ppy)2(CH3CN)2)PF6 (ppy = 2-phenylpyridine), containing two labile CH3CN groups, and NiCl2 are used as iridium and nickel-metal precursors, respectively, for postsynthetic decoration of the TpBpy COF. Nickel 118-124 sperm associated antigen 17 Homo sapiens 18-21 35420409-1 2022 We report an electrolysis system using NiFe layered double hydroxide/CoMoO4/nickel foam (NFLDH/CMO/NF) as the anode and CMO/NF as the cathode for simultaneous phenol electro-oxidation and water electrolysis. Nickel 76-82 neurofascin Homo sapiens 99-101 35505126-1 2022 HIGHLIGHTS: Three-dimensional (3D) core-shell heterostructured NixSy@MnOxHy nanorods grown on nickel foam (NixSy@MnOxHy/NF) were successfully fabricated via a simple hydrothermal reaction and a subsequent electrodeposition process. Nickel 94-100 neurofascin Homo sapiens 120-122 35505126-5 2022 Herein, an interface engineering coupled with shell-protection strategy was applied to construct three-dimensional (3D) core-shell NixSy@MnOxHy heterostructure nanorods grown on nickel foam (NixSy@MnOxHy/NF) as a bifunctional electrocatalyst. Nickel 178-184 neurofascin Homo sapiens 204-206 35144392-8 2022 J. Curtis Nickel may have a significant influence on CP/CPPS research with more publications and cocitations. Nickel 10-16 ceruloplasmin Homo sapiens 53-60 35405526-0 2022 Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo. Nickel 21-27 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 74-78 35474514-3 2022 OBJECTIVES: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Nickel 64-70 filaggrin Homo sapiens 49-52 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 39-45 filaggrin Homo sapiens 12-15 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 205-211 filaggrin Homo sapiens 12-15 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 205-211 filaggrin Homo sapiens 236-239 35182015-0 2022 Assessing Long-Term Cycling Stability of Single-Crystal Versus Polycrystalline Nickel-Rich NCM in Pouch Cells with 6 mAh cm-2 Electrodes. Nickel 79-85 CWC22 spliceosome associated protein homolog Homo sapiens 91-94 35150872-0 2022 Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway. Nickel 0-6 matrix metallopeptidase 2 Homo sapiens 94-98 35150872-0 2022 Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway. Nickel 0-6 AKT serine/threonine kinase 1 Homo sapiens 116-119 35348615-1 2022 OBJECTIVES: To compare patient-reported pain, discomfort, and difficulty in maintaining proper brushing between nickel-titanium closed-coil springs (CS) and elastomeric power chains (PC) when used for space closure. Nickel 112-118 citrate synthase Homo sapiens 149-151 35130529-3 2022 This study proposed an efficient and economic method of coating amorphous Ni3S2 compound on the Nickel metal current collector (Ni-S/Ni). Nickel 96-102 solute carrier family 5 member 5 Homo sapiens 128-132 35085411-3 2022 Here we disclose an efficient new nickel-catalyzed protocol for the C-N cross-coupling of amides and 2"-(pseudo)halide-substituted acetophenones, for the first time where the (pseudo)halide is chloride or sulfonate, which makes use of the commercial bisphosphine ligand PAd2-DalPhos ( L4 ) in combination with an organic amine base/halide scavenger, leading to 4-quinolones. Nickel 34-40 peptidyl arginine deiminase 2 Homo sapiens 270-274 35329619-7 2022 After vanadium and nickel contamination, compared with Cat-1, the gasoline yield and total liquid yield of Cat-2 could increase by 1.97% and 1.24%, respectively, with the bottom yield decreasing by 1.80 percentage points. Nickel 19-25 solute carrier family 7 member 2 Homo sapiens 107-112 35359602-1 2022 Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Nickel 174-180 filaggrin Homo sapiens 53-62 35359602-1 2022 Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Nickel 174-180 filaggrin Homo sapiens 64-67 35359602-4 2022 The goal of the study was to analyse the distribution of such cleavable motifs in the human proteome and examine FLG vulnerability of nickel hydrolysis. Nickel 134-140 filaggrin Homo sapiens 113-116 35359602-11 2022 Ni2+-assisted cleavage of barrier proteins, including FLG, may contribute to clinical disease associated with nickel exposure. Nickel 110-116 filaggrin Homo sapiens 54-57 35179160-1 2022 Chemical vapor deposited (CVD) amorphous tantalum-oxy nitride film on porous three-dimensional (3D) nickel foam (TaNx(Oy)/NF) utilizing tantalum precursor, tris(diethylamino)(ethylimino)tantalum(V), ((Ta(NEt)(NEt2)3)) with preformed Ta-N bonds is reported as a potential self-supported electrocatalyst for hydrogen evolution reaction (HER). Nickel 100-106 neurofascin Homo sapiens 122-124 35080388-6 2022 This strategy enables the use of a nickel-rich LiNi0.83Co0.07Mn0.1O2 cathode to deliver a reversible capacity of 201.5 mAh g-1 at a considerable loading of 4.8 mg cm-2, featuring performance metrics for an SSB that is competitive with those of traditional Li-ion systems. Nickel 35-41 small RNA binding exonuclease protection factor La Homo sapiens 206-209 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Nickel 293-296 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-124 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Nickel 293-296 solute carrier organic anion transporter family member 1B3 Homo sapiens 126-133 34994990-0 2022 Air-Stable High-Nickel Cathode with Reinforced Electrochemical Performance Enabled by Convertible Amorphous Li2 CO3 Modification. Nickel 16-22 ATP binding cassette subfamily A member 12 Homo sapiens 108-111 34994990-3 2022 Herein, a stable high-nickel cathode was rationally designed via in-situ induction of a dense amorphous Li2 CO3 on the particle surface by a preemptive atmosphere control. Nickel 22-28 ATP binding cassette subfamily A member 12 Homo sapiens 104-107 35243823-3 2022 The well-designed Ni3 S2 @NiFe PBA composite as precursor displays a unique spherical magic cube architecture composed of nanocubes, which even maintains after a phosphating treatment to obtain the derived Ni3 S2 /Fe-NiPx on nickel foam. Nickel 225-231 general transcription factor IIE subunit 1 Homo sapiens 214-216 35147635-1 2022 We describe facile synthetic methods for accessing linear cationic tetrylene nickel(0) complexes (SiiPDippE Ni(PPh3)3)+ (E = Ge (4) and Sn (5); SiiPDipp = ((iPr3Si)(Dipp)N)-), which feature donor-acceptor E-Ni triple bonds. Nickel 77-83 caveolin 1 Homo sapiens 111-115 35118486-1 2022 A practical nickel- and photoredox-catalyzed Csp3-H monofluoroalkenylation through chelation-assisted Csp2-F bond cleavage of gem-difluoroalkenes for the synthesis of stereodefined tetrasubstituted fluoroalkenes has been developed. Nickel 12-18 regulator of calcineurin 2 Homo sapiens 102-106 35118486-1 2022 A practical nickel- and photoredox-catalyzed Csp3-H monofluoroalkenylation through chelation-assisted Csp2-F bond cleavage of gem-difluoroalkenes for the synthesis of stereodefined tetrasubstituted fluoroalkenes has been developed. Nickel 12-18 GTP binding protein overexpressed in skeletal muscle Homo sapiens 126-129 35209219-0 2022 Chlorogenic Acid-Loaded Mesoporous Silica Nanoparticles Modified with Hexa-Histidine Peptides Reduce Skin Allergies by Capturing Nickel. Nickel 129-135 hexosaminidase subunit alpha Homo sapiens 70-74 35209219-3 2022 In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His6), making it a strong nickel chelator. Nickel 154-160 moesin Homo sapiens 47-50 35209219-3 2022 In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His6), making it a strong nickel chelator. Nickel 154-160 hexosaminidase subunit alpha Homo sapiens 88-92 35209219-3 2022 In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His6), making it a strong nickel chelator. Nickel 154-160 moesin Homo sapiens 124-127 35209219-5 2022 In vitro and in vivo experiments revealed that the synthesized MSN-His6@CGA nanoparticles exhibited more stable and stronger chelation, better biocompatibility, and ideal allergy-relieving ability, whether for environmental metal contamination or for allergic contact dermatitis caused by prolonged nickel exposure. Nickel 299-305 moesin Homo sapiens 63-66 35182295-4 2022 The coordination geometry around the central nickel (AZ-3) and cobalt (AZ-5) atoms was square planar bipyramidal. Nickel 45-51 ornithine decarboxylase antizyme 3 Homo sapiens 53-57 35175791-3 2022 This work leverages modern nickel-catalyzed electrochemical sp2-sp3 decarboxylative coupling reactions, enabled by silver nanoparticle-modified electrodes, to intuitively assemble terpene natural products and complex polyenes by using simple modular building blocks. Nickel 27-33 Sp2 transcription factor Homo sapiens 60-63 35175791-3 2022 This work leverages modern nickel-catalyzed electrochemical sp2-sp3 decarboxylative coupling reactions, enabled by silver nanoparticle-modified electrodes, to intuitively assemble terpene natural products and complex polyenes by using simple modular building blocks. Nickel 27-33 Sp3 transcription factor Homo sapiens 64-67 35424548-7 2022 Finally, this review will summarize recent research focus and recommend future research directions for nickel-rich NCM cathodes. Nickel 103-109 CWC22 spliceosome associated protein homolog Homo sapiens 115-118 35295125-6 2021 Nickel exposure resulted in no major histological changes within RHG or RHS-LC, or cytokine release into the microfluidics compartment, but did result in an increased activation of LC as observed by the increased mRNA levels of CD1a, CD207, HLA-DR, and CD86 in the dermal compartment (hydrogel of RHS-LC (PCR)). Nickel 0-6 CD1a molecule Homo sapiens 228-232 35295125-6 2021 Nickel exposure resulted in no major histological changes within RHG or RHS-LC, or cytokine release into the microfluidics compartment, but did result in an increased activation of LC as observed by the increased mRNA levels of CD1a, CD207, HLA-DR, and CD86 in the dermal compartment (hydrogel of RHS-LC (PCR)). Nickel 0-6 CD207 molecule Homo sapiens 234-239 35295125-6 2021 Nickel exposure resulted in no major histological changes within RHG or RHS-LC, or cytokine release into the microfluidics compartment, but did result in an increased activation of LC as observed by the increased mRNA levels of CD1a, CD207, HLA-DR, and CD86 in the dermal compartment (hydrogel of RHS-LC (PCR)). Nickel 0-6 CD86 molecule Homo sapiens 253-257 35032835-5 2022 Nickel particles precipitated colitis in mice bearing mutations of the IBD susceptibility protein A20/TNFAIP3. Nickel 0-6 tumor necrosis factor, alpha-induced protein 3 Mus musculus 98-101 35032835-5 2022 Nickel particles precipitated colitis in mice bearing mutations of the IBD susceptibility protein A20/TNFAIP3. Nickel 0-6 tumor necrosis factor, alpha-induced protein 3 Mus musculus 102-109 35032835-6 2022 Nickel particles also exacerbated dextran sulfate sodium-induced colitis in mice harboring myeloid cell-specific Atg5 deficiency. Nickel 0-6 autophagy related 5 Mus musculus 113-117 35140304-0 2022 Multiscale characterization of seawater pipe erosion of B10 copper-nickel alloy welded joints. Nickel 67-73 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 56-59 35048936-2 2022 Herein, nitrogen and iron co-doped Ni3S2 and NiP2 heterostructures with high efficiency oxygen evolution reaction (OER) and urea oxidation reaction (UOR) performances were firstly successfully prepared on nickel foam by hydrothermal and high-temperature calcination methods. Nickel 205-211 BCL2 interacting protein 2 Homo sapiens 45-49 35018914-1 2022 In contrast to the typical Csp2-H activation, a PN3P-Nickel complex chemoselectively cleaved the benzylic Csp3-H bond of toluene in the presence of KHMDS, presumably via an in situ generated potassium benzyl intermediate. Nickel 53-59 regulator of calcineurin 2 Homo sapiens 27-31 35099020-5 2022 Metallochaperones and accessory proteins (SlyD, HypA, HypB, UreD, UreE, UreF and UreG) form specific protein complexes to allow transfer of nickel from one protein to another without releasing the toxic metal to the cytoplasm. Nickel 140-146 pre-mRNA processing factor 40 homolog A Homo sapiens 48-52 35099020-5 2022 Metallochaperones and accessory proteins (SlyD, HypA, HypB, UreD, UreE, UreF and UreG) form specific protein complexes to allow transfer of nickel from one protein to another without releasing the toxic metal to the cytoplasm. Nickel 140-146 SET domain containing 2, histone lysine methyltransferase Homo sapiens 54-58 35099020-6 2022 The role of SlyD is not fully understood, but it can interact with and transfer its nickel to HypB. Nickel 84-90 SET domain containing 2, histone lysine methyltransferase Homo sapiens 94-98 35099020-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 39-45 SET domain containing 2, histone lysine methyltransferase Homo sapiens 66-70 35099020-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 39-45 pre-mRNA processing factor 40 homolog A Homo sapiens 74-78 35099020-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 107-113 SET domain containing 2, histone lysine methyltransferase Homo sapiens 66-70 35099020-7 2022 In the hydrogenase maturation pathway, nickel is transferred from HypB to HypA, which can then deliver its nickel to the hydrogenase large subunit precursor. Nickel 107-113 pre-mRNA processing factor 40 homolog A Homo sapiens 74-78 35099020-8 2022 In Helicobacter pylori, the urease maturation pathway receives its nickel from HypA of the hydrogenase maturation pathway via the formation of a HypA/UreE2 complex. Nickel 67-73 pre-mRNA processing factor 40 homolog A Homo sapiens 79-83 35099020-8 2022 In Helicobacter pylori, the urease maturation pathway receives its nickel from HypA of the hydrogenase maturation pathway via the formation of a HypA/UreE2 complex. Nickel 67-73 pre-mRNA processing factor 40 homolog A Homo sapiens 145-149 35425390-2 2022 The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp2-Csp3 bond, which provided an efficient method for the synthesis of primary alkylated arenes. Nickel 4-10 regulator of calcineurin 2 Homo sapiens 153-157 34995056-0 2022 Attenuation of Ni(0) Decomposition: Mechanistic Insights into AgF-Assisted Nickel-Mediated Silylation. Nickel 75-81 angiopoietin like 6 Homo sapiens 62-65 34995056-3 2022 While we recently developed AgF-assisted nickel catalysis to cross-couple methyl ethers and silylmagnesium reagents, the intriguing catalytic role of AgF and the actual active nickel species remains elusive. Nickel 41-47 angiopoietin like 6 Homo sapiens 28-31 34995056-3 2022 While we recently developed AgF-assisted nickel catalysis to cross-couple methyl ethers and silylmagnesium reagents, the intriguing catalytic role of AgF and the actual active nickel species remains elusive. Nickel 41-47 angiopoietin like 6 Homo sapiens 150-153 34995056-3 2022 While we recently developed AgF-assisted nickel catalysis to cross-couple methyl ethers and silylmagnesium reagents, the intriguing catalytic role of AgF and the actual active nickel species remains elusive. Nickel 176-182 angiopoietin like 6 Homo sapiens 28-31 2681705-1 1989 Differential thermal analysis, optical microscopy, scanning electron microscopy, and energy dispersive radiographic analysis were used to examine and analyze two failed platinum-palladium-gold pin-retained nickel-chromium castings. Nickel 206-212 dynein light chain LC8-type 1 Homo sapiens 193-196 35159659-4 2022 The result of XRD and Raman measurement confirms that rGO-Ni prepared at reaction time 20 min exhibit the highest reduction of GO and the presence of various Ni-S crystal structures such as NiS, NiS2, Ni3S2, and Ni3S4 due to decomposition of NiSO4. Nickel 190-193 solute carrier family 5 member 5 Homo sapiens 158-162 35013202-3 2022 Herein, we present an approach to fabricate a high surface distribution density of iridium (Ir) SAC on nickel-iron sulfide nanosheet arrays substrate (Ir1/NFS), which delivers a high water oxidation activity. Nickel 103-109 nischarin Homo sapiens 151-154 35585312-2 2022 Nickel-charged affinity resins and amylose resins are two commonly used matrices for the isolation of proteins with histidine tag (6x His-tag) and maltose binding protein (MBP) tag, respectively. Nickel 0-6 myelin basic protein Homo sapiens 147-170 35585312-2 2022 Nickel-charged affinity resins and amylose resins are two commonly used matrices for the isolation of proteins with histidine tag (6x His-tag) and maltose binding protein (MBP) tag, respectively. Nickel 0-6 myelin basic protein Homo sapiens 172-175 2620798-0 1989 Allosteric binding of nickel(II) to calmodulin. Nickel 22-28 calmodulin 1 Homo sapiens 36-46 2664140-2 1989 Part VIII: Plaque accumulation on metal ceramic restorations cast from noble and nickel-based alloys. Nickel 81-87 cytochrome c oxidase subunit 8A Homo sapiens 5-9 2566235-0 1989 Prostaglandin E1 and prostaglandin F2 alpha in exudate in nickel allergy. Nickel 58-64 small nucleolar RNA, H/ACA box 73A Homo sapiens 14-43 2702040-2 1989 Wild-type cells contained three major nickel-binding proteins with molecular masses of 68 kDa (p68), 55 kDa (p55), and 48 kDa (p48). Nickel 38-44 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 95-98 2702040-2 1989 Wild-type cells contained three major nickel-binding proteins with molecular masses of 68 kDa (p68), 55 kDa (p55), and 48 kDa (p48). Nickel 38-44 H3 histone pseudogene 44 Homo sapiens 109-112 2702040-2 1989 Wild-type cells contained three major nickel-binding proteins with molecular masses of 68 kDa (p68), 55 kDa (p55), and 48 kDa (p48). Nickel 38-44 interferon regulatory factor 9 Homo sapiens 127-130 2702040-3 1989 The p55 was present in high concentrations in the microsomal fraction, whereas the p68 nickel-binding protein predominated in the cytosolic fraction. Nickel 87-93 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 83-86 2659311-0 1989 Characterization of the inhibition effect induced by nickel on glucose-6-phosphate dehydrogenase and glutathione reductase. Nickel 53-59 glucose-6-phosphate dehydrogenase Saccharomyces cerevisiae S288C 63-96 2451465-3 1988 Presence of nickel in the purified serum alpha 2 M was demonstrated by Zeeman electrothermal atomic absorption spectrophotometry, consistent with findings decades ago by less refined and sensitive techniques. Nickel 12-18 alpha-2-macroglobulin Homo sapiens 41-50 2702040-5 1989 Both the p55 and p48 proteins appeared to be present in similar amounts in wild-type and nickel-resistant cell lines, based upon silver staining of two-dimensional gels, yet in the nickel-resistant B200 cells, these proteins could not be visualized by [63Ni] binding. Nickel 89-95 H3 histone pseudogene 44 Homo sapiens 9-12 2702040-5 1989 Both the p55 and p48 proteins appeared to be present in similar amounts in wild-type and nickel-resistant cell lines, based upon silver staining of two-dimensional gels, yet in the nickel-resistant B200 cells, these proteins could not be visualized by [63Ni] binding. Nickel 89-95 interferon regulatory factor 9 Homo sapiens 17-20 2702040-5 1989 Both the p55 and p48 proteins appeared to be present in similar amounts in wild-type and nickel-resistant cell lines, based upon silver staining of two-dimensional gels, yet in the nickel-resistant B200 cells, these proteins could not be visualized by [63Ni] binding. Nickel 181-187 H3 histone pseudogene 44 Homo sapiens 9-12 2702040-5 1989 Both the p55 and p48 proteins appeared to be present in similar amounts in wild-type and nickel-resistant cell lines, based upon silver staining of two-dimensional gels, yet in the nickel-resistant B200 cells, these proteins could not be visualized by [63Ni] binding. Nickel 181-187 interferon regulatory factor 9 Homo sapiens 17-20 2702040-8 1989 Among the nickel-binding proteins studied, the p55 contained nickel-binding sites that were the most resistant to exchange by excess nickel ions. Nickel 10-16 H3 histone pseudogene 44 Homo sapiens 47-50 2702040-8 1989 Among the nickel-binding proteins studied, the p55 contained nickel-binding sites that were the most resistant to exchange by excess nickel ions. Nickel 61-67 H3 histone pseudogene 44 Homo sapiens 47-50 2702040-8 1989 Among the nickel-binding proteins studied, the p55 contained nickel-binding sites that were the most resistant to exchange by excess nickel ions. Nickel 61-67 H3 histone pseudogene 44 Homo sapiens 47-50 2702040-9 1989 The microsomal fraction that contained the highest concentration of p55 also had the highest nickel-binding activity when standardized for protein concentration. Nickel 93-99 H3 histone pseudogene 44 Homo sapiens 68-71 2849206-7 1988 This hypothesis is further supported by the finding that when heme synthesis is blocked, hypoxia-, cobalt-, and nickel-induced Epo production are all markedly inhibited. Nickel 112-118 erythropoietin Homo sapiens 127-130 2849206-8 1988 A model is proposed in which a ligand-dependent conformational change in a heme protein accounts for the mechanism by which hypoxia as well as cobalt and nickel stimulate the production of Epo. Nickel 154-160 erythropoietin Homo sapiens 189-192 2976621-0 1988 Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4+ T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel. Nickel 0-6 interleukin 2 Homo sapiens 23-27 2976621-0 1988 Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4+ T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel. Nickel 0-6 interleukin 2 Homo sapiens 42-46 2976621-0 1988 Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4+ T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel. Nickel 0-6 CD4 molecule Homo sapiens 77-80 2976621-2 1988 Mononuclear cells from nickel-sensitive patients synthesized more DNA, produced more IL-2 and had more IL-2 receptor positive cells in response to nickel than did those of the control subjects. Nickel 23-29 interleukin 2 Homo sapiens 85-89 2976621-2 1988 Mononuclear cells from nickel-sensitive patients synthesized more DNA, produced more IL-2 and had more IL-2 receptor positive cells in response to nickel than did those of the control subjects. Nickel 23-29 interleukin 2 Homo sapiens 103-107 2976621-2 1988 Mononuclear cells from nickel-sensitive patients synthesized more DNA, produced more IL-2 and had more IL-2 receptor positive cells in response to nickel than did those of the control subjects. Nickel 147-153 interleukin 2 Homo sapiens 103-107 2976621-7 1988 In conclusion, nickel-induced peripheral blood mononuclear cell activation in vitro differs from microbial antigen-induced activation with respect to its modest or non-existent IFN-gamma response. Nickel 15-21 interferon gamma Homo sapiens 177-186 2448365-4 1987 After withdrawal of nickel from the culture medium, vimentin filaments remained attached to the cell periphery as the cells spread out again, but the cytokeratin filaments remained aggregated in a perinuclear position without reestablishing all peripheral connections. Nickel 20-26 vimentin Homo sapiens 52-60 2902003-1 1988 RFLP analysis of the HLA class II genes DRA, DQA, and DQB was performed in 33 patients with allergic contact eczema to nickel. Nickel 119-125 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 54-57 2958239-7 1987 The addition of ionic copper, cobalt, or nickel to trehalose-PFK solution prior to rapid drying results in a large increase in the activity recovered, and the presence of cadmium or manganese leads to a minor increase. Nickel 41-47 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 61-64 2822511-1 1987 This study reports the presence in AtT-20 corticotrophs of high affinity-low capacity receptors for arginine-vasopressin (AVP), whose binding capacity was considerably enhanced by the divalent metal ion nickel. Nickel 203-209 arginine vasopressin Mus musculus 100-126 2822511-2 1987 These binding sites, when analyzed in the presence of nickel, showed high affinity for AVP, vasotocin and oxytocin, but recognized to a lesser extent the V2-agonist 1-deamino-AVP, as well as V1-antagonists. Nickel 54-60 arginine vasopressin Mus musculus 87-90 2822511-2 1987 These binding sites, when analyzed in the presence of nickel, showed high affinity for AVP, vasotocin and oxytocin, but recognized to a lesser extent the V2-agonist 1-deamino-AVP, as well as V1-antagonists. Nickel 54-60 arginine vasopressin Mus musculus 175-178 3549912-1 1987 A comparison was made between the diagnostic value of assaying nickel-induced lymphocyte proliferation (lymphocyte transformation test, LTT) and migration inhibition factor (MIF) production in nickel contact sensitivity. Nickel 193-199 macrophage migration inhibitory factor Homo sapiens 174-177 2890191-1 1987 The administration of nickel to rats resulted in a dose-dependent increase in the level of hepatic glutathione and in the activities of glutathione reductase and glutathione-S-transferase with a concomitant decrease in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase. Nickel 22-28 glutathione-disulfide reductase Rattus norvegicus 136-157 2890191-1 1987 The administration of nickel to rats resulted in a dose-dependent increase in the level of hepatic glutathione and in the activities of glutathione reductase and glutathione-S-transferase with a concomitant decrease in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase. Nickel 22-28 hematopoietic prostaglandin D synthase Rattus norvegicus 162-187 2890191-1 1987 The administration of nickel to rats resulted in a dose-dependent increase in the level of hepatic glutathione and in the activities of glutathione reductase and glutathione-S-transferase with a concomitant decrease in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase. Nickel 22-28 gamma-glutamyltransferase 1 Rattus norvegicus 264-293 3602750-3 1987 The capacities of particulate nickel compounds to induce erythropoietin-mediated erythrocytosis in rats are closely correlated with their carcinogenic activities; hence erythrocytosis stimulation can serve as a screening test for carcinogenicity. Nickel 30-36 erythropoietin Rattus norvegicus 57-71 2948571-11 1987 The addition of ionic copper, cadmium, nickel, cobalt, calcium and manganese to trehalose-phosphofructokinase solutions prior to freeze-drying also increases the percentage of activity recovered after dissolution. Nickel 39-45 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 90-109 22175628-0 1986 Surface chemistry of nickel supported on TinO2n-1. Nickel 21-27 mex-3 RNA binding family member D Homo sapiens 41-45 3327431-8 1987 Acute treatment of rats with nickel, platinum, tin, antimony, bismuth, and cobalt results in induction of heme oxygenase, followed by decreased microsomal heme content and ALAS stimulation in the kidney. Nickel 29-35 5'-aminolevulinate synthase 1 Rattus norvegicus 172-176 3814534-0 1987 Lysozyme activity in ultrastructurally defined fractions of alveolar macrophages after inhalation exposure to nickel. Nickel 110-116 lysozyme C-like Oryctolagus cuniculus 0-8 3814534-4 1987 The lysozyme activity decreased in unfractionated as well as in fractionated macrophages from nickel exposed rabbits. Nickel 94-100 lysozyme C-like Oryctolagus cuniculus 4-12 3814534-8 1987 The decreased lysozyme activity is probably a direct effect of nickel on the macrophages. Nickel 63-69 lysozyme C-like Oryctolagus cuniculus 14-22 2946263-10 1986 The addition of ionic copper, cadmium, nickel, and cobalt to trehalose-PFK solutions prior to freezing also increases the percentage of activity recovered after thawing. Nickel 39-45 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 71-74 3478161-0 1986 HLA-A, -B and DR antigens in nickel sensitive females. Nickel 29-35 major histocompatibility complex, class I, A Homo sapiens 0-16 3490876-3 1986 There was no significant HLA association, although there was an increased frequency of DR4 in those patients who included nickel as one of their sensitivities (64% compared with 33% in controls), and an increase in DR6 in those patients who included sensitivity to a rubber accelerator (45% compared with 16% in controls). Nickel 122-128 major histocompatibility complex, class II, DR beta 4 Homo sapiens 87-90 3757145-2 1986 Cadmium (Cd2+), nickel (Ni2+) and chromate (Cr2O7) reduced the cloning efficiency of HSBP cells more than that of CHO cells whereas the reverse was true after treatment with mercury (Hg2+), manganese (Mn2+) and cobalt (Co2+). Nickel 16-22 selenium binding protein 1 Homo sapiens 85-89 3956821-3 1986 Atomic absorption analysis of the polyethlylene glycol precipitates (PEG ppt) from the sera of 16 patients--8 positive and 8 negative for cic--revealed an amount of nickel or chromium significantly higher in the PEG ppt from the sera of patients positive for cic. Nickel 165-171 tachykinin precursor 1 Homo sapiens 73-76 3956821-3 1986 Atomic absorption analysis of the polyethlylene glycol precipitates (PEG ppt) from the sera of 16 patients--8 positive and 8 negative for cic--revealed an amount of nickel or chromium significantly higher in the PEG ppt from the sera of patients positive for cic. Nickel 165-171 tachykinin precursor 1 Homo sapiens 216-219 9937709-0 1985 Adsorption probabilities of H2 and D2 on various flat and stepped nickel surfaces. Nickel 66-72 relaxin 2 Homo sapiens 28-37 3093801-0 1986 Nickel chelate chromatography of human immune interferon. Nickel 0-6 interferon gamma Homo sapiens 39-56 6506083-4 1984 Administration of nickel ions at a dose of 60 mg/kg body wt to female rats did not reduce to a significant level the content or the activity of any of the hepatic microsomal enzymes mentioned above, but did interfere in the de novo synthesis of cytochrome P-450 following phenobarbital treatment. Nickel 18-24 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 245-261 3977943-0 1985 Difference circular dichroism studies of copper and nickel binding to D-penicillamine in the presence of human serum albumin. Nickel 52-58 albumin Homo sapiens 111-124 3977943-1 1985 The binding of copper and nickel to D-penicillamine in the presence of human serum albumin (HSA) has been studied using difference circular dichroism (CD). Nickel 26-32 albumin Homo sapiens 77-90 3978208-8 1985 Upper limits were placed on the amount of manganese, molybdenum, and nickel per rhodopsin as 0.019, 0.019, and 0.006, respectively. Nickel 69-75 rhodopsin Bos taurus 80-89 3967644-7 1985 In an in vivo NK assay, the clearance of [125I]iododeoxyuridine-labeled YAC-1 tumor cells from the lungs of nickel-treated mice was significantly reduced compared with saline injected controls. Nickel 108-114 ADP-ribosyltransferase 1 Mus musculus 72-77 3987257-0 1985 Nickel in tap water. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 10-13 6090848-0 1984 Inhibition of prolactin and growth hormone secretion by nickel. Nickel 56-62 prolactin Rattus norvegicus 14-23 6090848-0 1984 Inhibition of prolactin and growth hormone secretion by nickel. Nickel 56-62 gonadotropin releasing hormone receptor Rattus norvegicus 28-42 6090848-1 1984 Nickel (Ni++) is a potent inhibitor of prolactin (PRL) secretion from isolated rat pituitary quarters in vitro, suppressing both basal PRL release and the stimulation of PRL secretion due to theophylline and dibutyryl cyclic AMP. Nickel 0-6 prolactin Rattus norvegicus 39-48 6090848-1 1984 Nickel (Ni++) is a potent inhibitor of prolactin (PRL) secretion from isolated rat pituitary quarters in vitro, suppressing both basal PRL release and the stimulation of PRL secretion due to theophylline and dibutyryl cyclic AMP. Nickel 0-6 prolactin Rattus norvegicus 50-53 6090848-1 1984 Nickel (Ni++) is a potent inhibitor of prolactin (PRL) secretion from isolated rat pituitary quarters in vitro, suppressing both basal PRL release and the stimulation of PRL secretion due to theophylline and dibutyryl cyclic AMP. Nickel 0-6 prolactin Rattus norvegicus 135-138 6090848-1 1984 Nickel (Ni++) is a potent inhibitor of prolactin (PRL) secretion from isolated rat pituitary quarters in vitro, suppressing both basal PRL release and the stimulation of PRL secretion due to theophylline and dibutyryl cyclic AMP. Nickel 0-6 prolactin Rattus norvegicus 135-138 6745235-0 1984 Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides. Nickel 51-57 lysozyme C-like Oryctolagus cuniculus 0-8 6745235-3 1984 In the nickel-exposed rabbits lysozyme activity in the mucous membrane from the left main bronchus was also estimated. Nickel 7-13 lysozyme C-like Oryctolagus cuniculus 30-38 6745235-4 1984 Following nickel exposure the lysozyme level was significantly decreased in lavage fluid, macrophages, and in culture medium from incubated macrophages but remained unchanged in the mucous membrane. Nickel 10-16 lysozyme C-like Oryctolagus cuniculus 30-38 18963641-6 1984 The relationship between the forms and extraction properties of the iron(II) and iron(III) PAR chelates are discussed in connection with those of the nickel(II) and cobalt(III) complexes. Nickel 150-156 jumping translocation breakpoint Homo sapiens 91-94 6311457-2 1983 The contribution of non-specific phosphatase enzymes is assessed in the presence of nickel ions which specifically inhibit 5"-nucleotidase. Nickel 84-90 5'-nucleotidase ecto Homo sapiens 123-138 6691936-1 1984 Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. Nickel 76-82 albumin Homo sapiens 45-48 6370091-5 1984 This finding confirms the exclusion of GAA from 17q25----17qter reported by Nickel et al. Nickel 76-82 alpha glucosidase Homo sapiens 39-42 6398288-5 1984 New developments in the association of Ni2+ with proteins suggest: a role for the Ni3+/Ni2+ redox couple in bacterial proteins; the involvement of the primary copper/nickel binding site of human serum albumin in antigen recognition by antibodies with nickel-related specificity; and that Ni2+ can act as an antagonist of essential metal ions. Nickel 166-172 albumin Homo sapiens 201-208 6398288-5 1984 New developments in the association of Ni2+ with proteins suggest: a role for the Ni3+/Ni2+ redox couple in bacterial proteins; the involvement of the primary copper/nickel binding site of human serum albumin in antigen recognition by antibodies with nickel-related specificity; and that Ni2+ can act as an antagonist of essential metal ions. Nickel 251-257 albumin Homo sapiens 201-208 6236651-0 1984 [Interface zone between the chromium-nickel alloy Gisadent NCA and fired ceramic materials]. Nickel 37-43 CEA cell adhesion molecule 6 Homo sapiens 59-62 6413567-0 1983 Asthma and IgE antibodies induced by chromium and nickel salts. Nickel 50-56 immunoglobulin heavy constant epsilon Homo sapiens 11-14 6860759-1 1983 Employing equilibrium dialysis, the binding ability of nickel, copper, and chromium from the corrosion of Biobond, Sybraloy, and Vitallium dental alloys in an inorganic saliva to glycoprotein, mucin, amylase, and lysozyme is reported. Nickel 55-61 LOC100508689 Homo sapiens 193-198 6851522-0 1983 Nickel in tap water. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 10-13 6851522-1 1983 Nickel analyses of tap water from several sources in Copenhagen gave up to 490 X 10(-6) g X 1(-1) in the first 250 ml portions. Nickel 0-6 nuclear RNA export factor 1 Homo sapiens 19-22 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 alpha-2-macroglobulin Homo sapiens 189-210 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 transferrin Homo sapiens 218-229 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 transferrin Homo sapiens 231-234 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 serpin family A member 1 Homo sapiens 237-256 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 serpin family A member 1 Homo sapiens 258-262 6663071-1 1983 Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Nickel 64-70 ceruloplasmin Homo sapiens 265-278 6923908-1 1982 We demonstrate that nickel++ (Ni) can replace Mg in the formation of the C3b,Bb enzyme, and that Ni is more efficient in enzyme formation than Mg. Nickel 20-28 complement C3 Homo sapiens 73-76 7135423-4 1982 The uptake of the NiS particles was inhibited by trifluoperazine, a calmodulin antagonist, implicating intracellular Ca2+ in this phagocytosis process. Nickel 18-21 calmodulin 1 Homo sapiens 68-78 6279506-5 1982 Divalent cations with Ca2+ antagonistic action such as manganese M(n2+), nickel (Ni2+), and cobalt (Co2+) blocked the aldosterone secretory response to AII, ACTH, and K+. Nickel 73-79 angiotensinogen Homo sapiens 152-155 6279506-5 1982 Divalent cations with Ca2+ antagonistic action such as manganese M(n2+), nickel (Ni2+), and cobalt (Co2+) blocked the aldosterone secretory response to AII, ACTH, and K+. Nickel 73-79 proopiomelanocortin Homo sapiens 157-161 6175135-7 1982 Compared with non-nickel-sensitive women, a woman who has become nickel sensitized ran an increased risk of developing hand eczema. Nickel 18-24 RAN, member RAS oncogene family Homo sapiens 83-86 6175135-7 1982 Compared with non-nickel-sensitive women, a woman who has become nickel sensitized ran an increased risk of developing hand eczema. Nickel 65-71 RAN, member RAS oncogene family Homo sapiens 83-86 6175135-8 1982 And those who had first developed hand eczema ran an increased risk of subsequently developing nickel allergy. Nickel 95-101 RAN, member RAS oncogene family Homo sapiens 46-49 18962938-4 1981 On the basis of experimental results obtained, an explanation for the negative deviation of the calibration graphs noticed in ETA-AA is given, with nickel and barium atomization data as examples. Nickel 148-154 endothelin receptor type A Homo sapiens 126-129 7111338-3 1982 Furthermore, preliminary studies provide evidence for the existence in pineal gland of a thermo-stable proteinaceous substance (NIS) which inactivates NAT but not other enzymes involved in the synthesis of melatonin. Nickel 128-131 bromodomain containing 2 Homo sapiens 151-154 7111338-4 1982 Inactivation of NAT by NIS is blocked by addition of 0.5 mM acetyl coenzyme A, but not coenzyme A, 0.1 M NaF or 4 mM beta-mercaptoethanol. Nickel 23-26 bromodomain containing 2 Homo sapiens 16-19 7342374-0 1981 Decreased level of lysozyme in rabbit lung lavage fluid after inhalation of low nickel concentrations. Nickel 80-86 lysozyme C-like Oryctolagus cuniculus 19-27 6155299-3 1980 ABR interact in vitro with determinants severely perturbed on nickel-insulin, partially perturbed on proinsulin and desasparagine-desalanine insulin, and unaffected on zinc-insulin or zinc-free monocomponent insulin. Nickel 62-68 active BCR-related gene Mus musculus 0-3 6155299-4 1980 ABH, on the other hand, interact in vitro with determinants severely perturbed on proinsulin and desasparagine-desalanine insulin but stabilized on nickel-insulin and zinc-insulin. Nickel 148-154 alkB homolog 1, histone H2A dioxygenase Mus musculus 0-3 6986793-0 1980 Cadmium and nickel influence on blood pressure, plasma renin, and tissue mineral concentrations. Nickel 12-18 renin Rattus norvegicus 55-60 119281-10 1979 As a result, the optimum conditions for the quantitative adsorption of copper(II), zinc(II), cadmium(II), cobalt(II), nickel(II) and manganese(II) were as follows: NO3- less than 0.01 mol . Nickel 118-124 NBL1, DAN family BMP antagonist Homo sapiens 164-167 43739-1 1978 The kinetic properties of 5"-Nucleotidase were investigated in untreated patients with liver cirrhosis at 37 degrees C. Mg+2 and Mn+2 were found to activate both normal and liver cirrhotic 5"-Nucleotidase, but Nickel inhibited the enzyme in both systems competitively. Nickel 211-217 5'-nucleotidase ecto Homo sapiens 26-41 277462-2 1977 Subsequently, a method was perfected for incorporating nickel or tungsten powder into the Ag3 Sn ingot. Nickel 55-61 anterior gradient 3, protein disulphide isomerase family member Homo sapiens 90-93 334441-0 1977 Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron. Nickel 81-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-30 18352-0 1977 Nickel cytochrome c. Nickel 0-6 cytochrome c, somatic Homo sapiens 7-19 18352-2 1977 Nickel cytochrome c has been synthesized by the reaction of metal-free porphyrin cytochrome c with Ni(II) ions in 0.6 Mglycylglycine and 4 M KSCN. Nickel 0-6 cytochrome c, somatic Homo sapiens 7-19 18352-2 1977 Nickel cytochrome c has been synthesized by the reaction of metal-free porphyrin cytochrome c with Ni(II) ions in 0.6 Mglycylglycine and 4 M KSCN. Nickel 0-6 cytochrome c, somatic Homo sapiens 81-93 18352-4 1977 Nickel cytochrome c has the same electrophoretic mobility, helicity and pK values of conformational transitions as the native enzyme. Nickel 0-6 cytochrome c, somatic Homo sapiens 7-19 16006-6 1977 Inhibitors of ATPase activity such as nickel/bathophenanthroline and the protein ATPase inhibitor of Pullman and Monroy (Pullman, M. E., and Monroy, G. C. (1963) J. Biol. Nickel 38-44 dynein axonemal heavy chain 8 Homo sapiens 14-20 4357307-0 1973 Prolactin secretion is specifically inhibited by nickel. Nickel 49-55 prolactin Homo sapiens 0-9 1008565-0 1976 Leukocyte migration inhibition assay (LIF) in nickel contact dermatitis. Nickel 46-52 LIF interleukin 6 family cytokine Homo sapiens 38-41 1008565-1 1976 A direct assay using the mixed leukocyte migration inhibition technique for leukocyte inhibition factor (LIF) production has shown that nickel-sensitive subjects can be distinguished from nonallergic controls. Nickel 136-142 LIF interleukin 6 family cytokine Homo sapiens 76-103 1008565-1 1976 A direct assay using the mixed leukocyte migration inhibition technique for leukocyte inhibition factor (LIF) production has shown that nickel-sensitive subjects can be distinguished from nonallergic controls. Nickel 136-142 LIF interleukin 6 family cytokine Homo sapiens 105-108 175863-1 1976 The glucose oxidase and catalase activities immobilized to the gamma-aminopropyltriethoxysilane derivative of nickel-impregnated silica alumina was controlled by several factors. Nickel 110-116 catalase Homo sapiens 24-32 5457934-0 1970 Nickel carbonyl inhibition of induction of aminopyrine demethylase activity in liver and lung. Nickel 0-6 methyl-CpG binding domain protein 2 Homo sapiens 55-66 14858771-0 1951 The effect of 2-3 dimercapto-propanol (BAL) on experimental nickel carbonyl poisoning. Nickel 60-66 poly(ADP-ribose) polymerase family member 9 Homo sapiens 39-42 33965013-2 2021 Herein, porous nickel foam (NF) with large surface area and magnetic property was used as the carrier of stir bar. Nickel 15-21 neurofascin Homo sapiens 28-30 33246655-2 2021 Herein, the P-doped cobalt carbonate hydroxide@NiMoO4 (P-CoCH@NiMoO4) nanowires@nanosheets double-shell hierarchical structure is successfully fabricated on nickel foam. Nickel 157-163 cochlin Homo sapiens 57-61 33851475-1 2021 A nickel/N-heterocyclic carbene (NHC) catalytic system has been developed for the borylation of aryl sulfoxides with B2(neop)2 (neop = neopentyl glycolato). Nickel 2-8 immunoglobulin kappa variable 5-2 Homo sapiens 117-126 33887540-5 2021 The c-Fos was processed by avidin-biotin-peroxidase complex intensified with nickel-enhanced 3,3"-diaminobenzidine tetrahydrochloride. Nickel 77-83 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 4-9 33904565-1 2021 A promising electrode for hydrogen evolution reaction (HER) has been prepared via a reduction process to form NiF2 nanorod arrays directly grown on a 3D nickel foam. Nickel 153-159 zinc finger protein 335 Homo sapiens 110-114 33908546-2 2021 Herein, a simple phosphoselenization method was used to prepare Co2P and CoSe2 coupled nanosheet and nanoneedle composite materials on nickel foam (Co2P/CoSe2/NF). Nickel 135-141 neurofascin Homo sapiens 159-161 33982720-2 2021 The Ni(I) species and chlorine atom radical Cl were generated via the ligand to metal charge transfer (LMCT) process of the NiCl2(PPh3)2, which allows nickel(IV)-phosphorus species in situ formation, giving various tertiary phosphine oxides under photocatalyst-free conditions. Nickel 152-158 protein phosphatase 4 catalytic subunit Homo sapiens 125-137 33977662-5 2021 Specially, PA2-Fe-MoS2 grown on nickel foam (PA2-Fe-MoS2/NF) exhibits excellent OER activity (218 mV@20 mA cm-2) and durability, even superior to RuO2 and many other previously reported OER catalysts. Nickel 32-38 neurofascin Homo sapiens 57-59 33656230-2 2021 Here we describe the construction of a temperature-programmed reduction-infrared spectroscopy apparatus (TPR-IR) to analyze the gas flows during the reduction of nickel, molybdenum, and tungsten phosphates. Nickel 162-168 translocated promoter region, nuclear basket protein Homo sapiens 105-108 33881964-4 2021 Herein, a facile and unique hot-pressing method is adopted to decorate the MOF nanoparticles on nickel foam (ZIF-8/NF), which simultaneously serves as self-supporting substrate of ZIF-8 nanoparticles and electrode of a self-powered multifunctional purification system. Nickel 96-102 neurofascin Homo sapiens 109-117 33733573-4 2021 We demonstrate that platinum and cisplatin activate pathways downstream of TLR4 to a similar extent as the known TLR4 agonists LPS and nickel. Nickel 135-141 toll like receptor 4 Homo sapiens 113-117 33912899-8 2021 Biochemical analyses revealed that G561E impairs the recognition of an adjacent tryptophan-acidic motif by the kinesin-1 subunit kinesin light chain 2 (KLC2), interfering with NIS maturation beyond the endoplasmic reticulum, and reducing iodide accumulation. Nickel 176-179 kinesin light chain 2 Homo sapiens 129-150 33912899-8 2021 Biochemical analyses revealed that G561E impairs the recognition of an adjacent tryptophan-acidic motif by the kinesin-1 subunit kinesin light chain 2 (KLC2), interfering with NIS maturation beyond the endoplasmic reticulum, and reducing iodide accumulation. Nickel 176-179 kinesin light chain 2 Homo sapiens 152-156 33933337-10 2021 When the subject"s urinary nickel level increased 1-fold, the eGFR level significantly decreased by 0.820 ml/min/1.73 m2. Nickel 27-33 epidermal growth factor receptor Homo sapiens 62-66 33847109-0 2021 Realization of a High-Voltage and High-Rate Nickel-Rich NCM Cathode Material for LIBs by Co and Ti Dual Modification. Nickel 44-50 CWC22 spliceosome associated protein homolog Homo sapiens 56-59 33784463-2 2021 The visible-light irradiation of NiCl2(PPh3)2 allows the generation of highly reactive nickel(II)-phosphorus species that subsequently migrate into the internal alkyne of the 1,3-enynes and protonate the resulting vinyl nickel species, leading to various phosphinoyl 1,3-butadienes under mild reaction conditions. Nickel 87-93 protein phosphatase 4 catalytic subunit Homo sapiens 33-45 33388585-2 2021 In this study, iron (Fe), manganese (Mn) co-doped three-dimensional (3D) Ni3S2 nanoflowers were in situ assembled by many inter-connected 2D nanosheets on nickel foam (NF) via hydrothermal and sulfuration treatment. Nickel 155-161 general transcription factor IIE subunit 1 Homo sapiens 21-23 33127139-4 2021 The results demonstrated that the addition of the BCP binder yielded remarkable increase in soil pH, unconfined compressive strength, and relative binding intensity index (IR) of target heavy metals including nickel (Ni) and zinc (Zn), while significantly decreased the electrical conductivity and leachability of contaminated soil. Nickel 209-215 opsin 1, short wave sensitive Homo sapiens 50-53 33733764-3 2021 In solution, this five-coordinate complex exists in equilibrium with four-coordinate [ONO]Ni(PPh3), and this ligand exchange equilibrium correlates with a valence tautomerization between the redox-active ligand and the nickel center. Nickel 219-225 caveolin 1 Homo sapiens 93-97 33749257-1 2021 Iron coordination polymer, Fe(ox)(H2O)2 (H2ox = oxalic acid) nanorods were grown on a nickel foam (NF) collector via a one-step electrodeposition method, which can be directly used as a freestanding and binder-free electrode for efficient oxygen evolution reaction (OER) electrocatalysis. Nickel 86-92 neurofascin Homo sapiens 99-101 33649793-0 2021 Induction of NUPR1 and AP-1 contributes to the carcinogenic potential of nickel. Nickel 73-79 nuclear protein 1, transcriptional regulator Homo sapiens 13-18 33649793-0 2021 Induction of NUPR1 and AP-1 contributes to the carcinogenic potential of nickel. Nickel 73-79 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 23-27 33592745-1 2021 A sandwich-type electrochemical immunosensor was developed for the detection of CEA where hollow magnetic silica coated nickel/carbon (Ni/C@SiO2) nanocomposites was used as an immobilized carrier and gold nanoparticle-coated PANI microsphere (CPS@PANI@Au) as electrochemical transducer. Nickel 120-126 CEA cell adhesion molecule 3 Homo sapiens 80-83 33758258-0 2021 The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation. Nickel 4-10 amyloid beta precursor protein Homo sapiens 52-64 33758258-9 2021 Taken together, our results indicate that Ni2+ ions enhance, whereas nickel chelation inhibits, Abeta peptide in vitro aggregation. Nickel 69-75 amyloid beta precursor protein Homo sapiens 96-101 33111387-1 2021 A nickel complex incorporating an N2O ligand with a rare eta2-N,N"-coordination mode was isolated and characterized by X-ray crystallography, as well as by IR and solid-state NMR augmented by 15N-labeling experiments. Nickel 2-8 DNA polymerase iota Homo sapiens 57-61 33111387-3 2021 Computational studies revealed that eta2-N2O binds to nickel slightly stronger than eta2-CO2 in this case, and comparably to or slightly stronger than eta2-CO2 to transition metals in general. Nickel 54-60 DNA polymerase iota Homo sapiens 36-40 33753167-4 2021 Here, using three different approaches for exosomes isolation: commercial kit, nickel based isolation and ultracentrifugation methods and various mammalian cell lines, we elucidated the mechanisms responsible for APE1 secretion. Nickel 79-85 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 213-217 33740985-4 2021 In this study, we proposed that exposure of human epidermal keratinocytes (HaCaT) to metal nanoparticles, such as nickel nanoparticles, dysregulates tight-junction associated proteins by interacting with the HIF-1alpha/miR-29b/MMPs axis. Nickel 114-120 hypoxia inducible factor 1 subunit alpha Homo sapiens 208-218 33740985-4 2021 In this study, we proposed that exposure of human epidermal keratinocytes (HaCaT) to metal nanoparticles, such as nickel nanoparticles, dysregulates tight-junction associated proteins by interacting with the HIF-1alpha/miR-29b/MMPs axis. Nickel 114-120 microRNA 29b-1 Homo sapiens 219-226 33569838-4 2021 As a proof-of-concept application, gamma-FeOOH NAs are developed as electrocatalysts for the oxygen evolution reaction (OER), where the sample grown on nickel foam (NF) exhibits superior performance of high catalytic current density, small Tafel slope, and exceptional durability, which is among the top level of FeOOH-based electrocatalysts. Nickel 152-158 neurofascin Homo sapiens 165-167 33625241-2 2021 Here, we describe the synthesis of a series of aryl and vinyl C-glycosides by stereoinvertive sp3-sp2 cross-coupling reactions of 2-deoxyglycosyl boronic acid derivatives with aryl or vinyl halide, mediated by a photoredox/nickel dual catalytic system. Nickel 223-229 Sp3 transcription factor Homo sapiens 94-97 33625241-2 2021 Here, we describe the synthesis of a series of aryl and vinyl C-glycosides by stereoinvertive sp3-sp2 cross-coupling reactions of 2-deoxyglycosyl boronic acid derivatives with aryl or vinyl halide, mediated by a photoredox/nickel dual catalytic system. Nickel 223-229 Sp2 transcription factor Homo sapiens 98-101 33533767-0 2021 An enzyme-free electrochemiluminescence insulin probe based on the regular attachment of ZnO nanoparticles on a 3-D nickel foam and H2O2 as an efficient co-reactant. Nickel 116-122 insulin Homo sapiens 40-47 33533767-1 2021 In this study, a highly sensitive, fast, and enzyme-free electrochemiluminescence (ECL) probe based on the decoration of zinc oxide nanoparticles on nickel foam is proposed for insulin determination. Nickel 149-155 insulin Homo sapiens 177-184 33369250-0 2021 Hierarchical CoP nanostructures on nickel foam as efficient bifunctional catalysts for water splitting. Nickel 35-41 caspase recruitment domain family member 16 Homo sapiens 13-16 33369250-3 2021 Here, for the first time, the precursor Co(CO3)0.5OH 0.11H2O (CHCH) with different microstructures on the surface of nickel foam (NF) was obtained with a facile hydrothermal method. Nickel 117-123 neurofascin Homo sapiens 130-132 33568646-2 2021 Herein, we report the nickel-catalyzed intermolecular cross-dialkylation of alkynes devoid of directing or activating groups to afford multiple aliphatic substituted alkenes in a syn-selective fashion at room temperature. Nickel 22-28 synemin Homo sapiens 179-182 32909649-2 2021 In this work, by simply depositing layered double hydroxides (LDH) on Co 3 O 4 /NF (NF = Nickel foam) nanosheets arrays, the hierarchical Co 3+ -riched materials based on LDH-Co 3 O 4 /NF were designed as highly active and stable electrocatalysts for water splitting. Nickel 89-95 neurofascin Homo sapiens 80-82 32909649-2 2021 In this work, by simply depositing layered double hydroxides (LDH) on Co 3 O 4 /NF (NF = Nickel foam) nanosheets arrays, the hierarchical Co 3+ -riched materials based on LDH-Co 3 O 4 /NF were designed as highly active and stable electrocatalysts for water splitting. Nickel 89-95 neurofascin Homo sapiens 84-86 32909649-2 2021 In this work, by simply depositing layered double hydroxides (LDH) on Co 3 O 4 /NF (NF = Nickel foam) nanosheets arrays, the hierarchical Co 3+ -riched materials based on LDH-Co 3 O 4 /NF were designed as highly active and stable electrocatalysts for water splitting. Nickel 89-95 neurofascin Homo sapiens 84-86 33543742-0 2021 Rod-like nickel doped Co3Se4/reduced graphene oxide hybrids as efficient electrocatalysts for oxygen evolution reactions. Nickel 9-15 kinetochore associated 1 Homo sapiens 0-3 33568646-3 2021 The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enables the syn-cross-dialkylation of alkynes at room temperature. Nickel 110-116 synemin Homo sapiens 129-132 33321388-10 2021 Significant interactions were detected for the association between nickel and study visit in relation to CRH (p < 0.02) and testosterone levels (p < 0.01). Nickel 67-73 corticotropin releasing hormone Homo sapiens 105-108 33444370-9 2021 In vitro, SlyD PPIase activity is down-regulated by nickel, independently of its C-terminal region reported to bind metals. Nickel 52-58 peptidylprolyl isomerase like 6 Homo sapiens 15-21 33576045-7 2021 Skin-homing (CLA+ ) nickel-reactive memory Th (Thmem hi ) cells identified individuals with a positive patch test for nickel with 100 % sensitivity [81%,100%] and 92% specificity [67%,100%]. Nickel 20-26 selectin P ligand Homo sapiens 13-16 33576045-7 2021 Skin-homing (CLA+ ) nickel-reactive memory Th (Thmem hi ) cells identified individuals with a positive patch test for nickel with 100 % sensitivity [81%,100%] and 92% specificity [67%,100%]. Nickel 118-124 selectin P ligand Homo sapiens 13-16 33058356-3 2021 N-truncated peptides at the positions 4 and 11 (Abeta 4-x and Abeta 11-x ) contain an amino-terminal copper and nickel (ATCUN) binding motif (NH 2 -Xxx-Zzz-His) that confer them different coordination sites and higher affinities for Cu(II) compared to the Abeta peptide. Nickel 112-118 amyloid beta precursor protein Homo sapiens 48-53 33551841-5 2020 Jurkat T cells transfected with the non-signaling molecule rat CD48 were found to bind to ligand-free SLBs containing >=2 wt% nickel-chelating lipids upon which calcium signaling was induced. Nickel 126-132 Cd48 molecule Rattus norvegicus 63-67 33415980-1 2021 The biological global carbon cycle is largely regulated through microbial nickel enzymes, including carbon monoxide dehydrogenase (CODH), acetyl coenzyme A synthase (ACS), and methyl coenzyme M reductase (MCR). Nickel 74-80 acyl-CoA synthetase short chain family member 2 Homo sapiens 138-164 33415980-1 2021 The biological global carbon cycle is largely regulated through microbial nickel enzymes, including carbon monoxide dehydrogenase (CODH), acetyl coenzyme A synthase (ACS), and methyl coenzyme M reductase (MCR). Nickel 74-80 acyl-CoA synthetase short chain family member 2 Homo sapiens 166-169 33415980-3 2021 We have established a mutant of nickel-substituted azurin as a scaffold upon which to develop protein-based models of enzymatic intermediates, including the organometallic states of ACS. Nickel 32-38 acyl-CoA synthetase short chain family member 2 Homo sapiens 182-185 33482469-0 2021 Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Nickel 0-6 transglutaminase 2 Homo sapiens 48-66 33482469-0 2021 Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Nickel 0-6 transglutaminase 2 Homo sapiens 68-71 33482469-0 2021 Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Nickel 0-6 sequestosome 1 Homo sapiens 117-123 33482469-0 2021 Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Nickel 0-6 sequestosome 1 Homo sapiens 124-127 33482469-12 2021 Our study demonstrated that nickel ion regulates autophagy flux and TG2 restricted nickel-dependent proteostasis. Nickel 28-34 transglutaminase 2 Homo sapiens 68-71 33482469-12 2021 Our study demonstrated that nickel ion regulates autophagy flux and TG2 restricted nickel-dependent proteostasis. Nickel 83-89 transglutaminase 2 Homo sapiens 68-71 33570137-6 2021 Nickel exposure triggered apoptosis in concomitant with the decreased expression of anti-apoptotic B-cell lymphoma protein (Bcl-2) and increased caspase-3/7 activity. Nickel 0-6 BCL2 apoptosis regulator Homo sapiens 124-129 33570137-6 2021 Nickel exposure triggered apoptosis in concomitant with the decreased expression of anti-apoptotic B-cell lymphoma protein (Bcl-2) and increased caspase-3/7 activity. Nickel 0-6 caspase 3 Homo sapiens 145-156 33570137-8 2021 Additionally, nickel suppressed astrocyte proliferation in a dose- and time-dependent manner by delaying G2 to M phase transition through the upregulation of cyclin B1 and p27 protein expression. Nickel 14-20 cyclin B1 Homo sapiens 158-167 33570137-8 2021 Additionally, nickel suppressed astrocyte proliferation in a dose- and time-dependent manner by delaying G2 to M phase transition through the upregulation of cyclin B1 and p27 protein expression. Nickel 14-20 dynactin subunit 6 Homo sapiens 172-175 33444370-10 2021 In vivo, a role of SlyD PPIase function was only revealed upon exposure to high nickel concentrations. Nickel 80-86 peptidylprolyl isomerase like 6 Homo sapiens 24-30 33372797-2 2021 Herein, the novel V-doped Ni3S2/NiS heterostructure nanorod arrays grown on nickel foam (VNS/NF-WM) are synthesized via a facile methanol-assisted hydrothermal method. Nickel 32-35 neurofascin Homo sapiens 93-95 33440888-2 2021 One optimized chitosan derivative was synthesized, and then tested (CS-HMF), in order to uptake nickel, mercury, and barium metal ions from single- and triple-component (multi-component) aqueous solutions. Nickel 96-102 citrate synthase Homo sapiens 68-70 33411400-3 2021 Here we report how a 3D highly ordered mesoporous Co 3 O 4 /nickel foam (om-Co 3 O 4 /NF) electrode fulfils those criteria in the electrochemical oxidation of 5-hydroxymethylfurfural (HMF) to value-added 2,5-furandicarboxylic acid (FDCA). Nickel 60-66 neurofascin Homo sapiens 86-88 33075723-0 2021 A highly sensitive electrochemiluminescence immunosensor for h-FABP determination based on self-enhanced luminophore coupled with ultrathin 2D nickel metal-organic framework nanosheets. Nickel 143-149 fatty acid binding protein 3 Homo sapiens 61-67 33075723-1 2021 In this work, a novel ECL immunosensor based on self-enhanced luminophore and ultrathin 2D nickel MOF nanosheets was fabricated for sensitive and specific detection of h-FABP. Nickel 91-97 fatty acid binding protein 3 Homo sapiens 168-174 33509031-11 2021 The static and dynamic tests of PTU F1 showed that the TtF of nickel-titanium instrument in all experimental groups was significantly higher than that in the control group. Nickel 62-68 ras homolog family member H Homo sapiens 55-58 33509031-13 2021 CONCLUSION: Regardless of dynamic or static model, TtF with irrigation was longer than that with non-irrigation, indicating that synchronous irrigation can increase the fatigue resistance of nickel-titanium instrument. Nickel 191-197 ras homolog family member H Homo sapiens 51-54 33197826-3 2021 Hpn is a protein of 60 amino acids, 47% of which are histidines, expressed by H. pylori and avid for nickel, characterized by the presence of an ATCUN (Amino Terminal Cu(II)- and Ni(II)-binding) motif and by two further histidine residues which can act as additional metal anchoring sites. Nickel 101-107 hepsin Homo sapiens 0-3 33398979-8 2020 After purification by nickel affinity column, the fusion protein His-TIMP-2 was identified by Western blotting method and its biological activity was detected by gelatin zymography. Nickel 22-28 TIMP metallopeptidase inhibitor 2 Homo sapiens 69-75 33348849-0 2020 Effects of Different Surface Native Pre-Oxides on the Hot Corrosion Properties of Nickel-Based Single Crystal Superalloys. Nickel 82-88 alcohol dehydrogenase iron containing 1 Homo sapiens 54-57 33348849-1 2020 A study is carried out on the effect of different surface native pre-oxides on hot corrosion of single crystal nickel-based superalloy at 900 C. The effect of different oxides formed by different superalloys through pre-oxidation on hot corrosion is verified by normal hot corrosion and tube sealing experiments. Nickel 111-117 alcohol dehydrogenase iron containing 1 Homo sapiens 79-82 33348849-1 2020 A study is carried out on the effect of different surface native pre-oxides on hot corrosion of single crystal nickel-based superalloy at 900 C. The effect of different oxides formed by different superalloys through pre-oxidation on hot corrosion is verified by normal hot corrosion and tube sealing experiments. Nickel 111-117 alcohol dehydrogenase iron containing 1 Homo sapiens 234-237 33348849-1 2020 A study is carried out on the effect of different surface native pre-oxides on hot corrosion of single crystal nickel-based superalloy at 900 C. The effect of different oxides formed by different superalloys through pre-oxidation on hot corrosion is verified by normal hot corrosion and tube sealing experiments. Nickel 111-117 alcohol dehydrogenase iron containing 1 Homo sapiens 234-237 32744741-1 2020 Detailed equilibrium, spectroscopic and SOD activity studies are reported on a nickel complex formed with the new metallopeptide bearing two nickel binding loops of NiSOD. Nickel 79-85 superoxide dismutase 1 Homo sapiens 40-43 32744741-1 2020 Detailed equilibrium, spectroscopic and SOD activity studies are reported on a nickel complex formed with the new metallopeptide bearing two nickel binding loops of NiSOD. Nickel 141-147 superoxide dismutase 1 Homo sapiens 40-43 33305529-9 2021 Intriguingly, NDRG1 interacts with metal ions, such as nickel, but is prone to aggregation in their presence. Nickel 55-61 N-myc downstream regulated 1 Homo sapiens 14-19 33098081-2 2020 The spectroscopic fluorescence quenching strategy was outlined to evaluate the binding mechanism and binding affinity of nickel (II) and chromium (III) complexes of secnidazole with bovine serum albumin (BSA). Nickel 121-127 albumin Homo sapiens 189-202 33300805-1 2020 Readily available aryldimethylsulfonium triflates react with zinc powder under nickel catalysis via the selective cleavage of the sp2-hybridized carbon-sulfur bond to produce salt-free arylzinc triflates under mild conditions. Nickel 79-85 Sp2 transcription factor Homo sapiens 130-133 32673864-9 2020 Nickel was found to first bind to phytochelatin (PC) after entering the worms" body and this PC-Ni complex was further transported by the ABC transporter, CeHMT-1, into the coelomocytes for further detoxification. Nickel 0-6 Heavy metal tolerance factor 1 Caenorhabditis elegans 155-162 33242201-11 2020 Numerous studies have measured elevated levels of toxic metals in e-cig aerosols including lead, nickel, chromium, and manganese. Nickel 97-103 fibronectin 1 Homo sapiens 68-71 33254626-0 2020 The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: In vitro and in vivo studies. Nickel 22-28 microRNA 21a Mus musculus 12-18 33254626-0 2020 The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: In vitro and in vivo studies. Nickel 22-28 matrix metallopeptidase 2 Mus musculus 50-55 33254626-0 2020 The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: In vitro and in vivo studies. Nickel 22-28 matrix metallopeptidase 9 Mus musculus 60-65 33254626-8 2020 These results were further confirmed by in vivo studies by intratracheal instillation of nickel nanoparticles into WT and miR-21 KO mice. Nickel 89-95 microRNA 21a Mus musculus 122-128 33244936-7 2020 The recombinant proteins of ALT2 were purified by nickel column (Ni+) affinity chromatography. Nickel 50-56 glutamic--pyruvic transaminase 2 Homo sapiens 28-32 32897613-3 2020 Uniform two-dimensional (2-D) Co-MOF nanosheets (Co-MNS) grow on nickel foam, followed by a MOF-mediated tandem (carbonization/phosphidation) pyrolysis. Nickel 65-71 lysine acetyltransferase 8 Homo sapiens 33-36 33107502-1 2020 [LSi(eta2-P4)] (L = CH[C(Me)N(Dipp)][C(CH2)N(Dipp)], Dipp = 2,6-diisopropylphenyl) forms well-defined 1 : 1 and 2 : 1 complexes with N-heterocyclic carbene nickel fragments. Nickel 156-162 DNA polymerase iota Homo sapiens 5-9 32991151-3 2020 In this work, a series of bitmetallic-, trimetallic-, and tetrametallic-MOF-74/NFs were grown in situ on nickel foam (NF) by a facile solvothermal route. Nickel 105-111 neurofascin Homo sapiens 79-81 33252192-4 2021 This minireview provides an overview of the state-of-the-art approaches for mild C-heteroatom bond formations highlights the developments in photoredox and nickel dual catalysis involving SET and energy transfer processes; photoexcited nickel cataylsis; electro and nickel dual catalysis; heterogeneous photoredox and nickel dual catalysis involving graphitic carbon nitride (mpg-CN), metal organic frameworks (MOFs) or semiconductor quantum dots (QDs); as well as more conventional zinc and nickel dual catalyzed reactions. Nickel 156-162 N-methylpurine DNA glycosylase Homo sapiens 376-379 33252192-4 2021 This minireview provides an overview of the state-of-the-art approaches for mild C-heteroatom bond formations highlights the developments in photoredox and nickel dual catalysis involving SET and energy transfer processes; photoexcited nickel cataylsis; electro and nickel dual catalysis; heterogeneous photoredox and nickel dual catalysis involving graphitic carbon nitride (mpg-CN), metal organic frameworks (MOFs) or semiconductor quantum dots (QDs); as well as more conventional zinc and nickel dual catalyzed reactions. Nickel 236-242 N-methylpurine DNA glycosylase Homo sapiens 376-379 33252192-4 2021 This minireview provides an overview of the state-of-the-art approaches for mild C-heteroatom bond formations highlights the developments in photoredox and nickel dual catalysis involving SET and energy transfer processes; photoexcited nickel cataylsis; electro and nickel dual catalysis; heterogeneous photoredox and nickel dual catalysis involving graphitic carbon nitride (mpg-CN), metal organic frameworks (MOFs) or semiconductor quantum dots (QDs); as well as more conventional zinc and nickel dual catalyzed reactions. Nickel 236-242 N-methylpurine DNA glycosylase Homo sapiens 376-379 33252192-4 2021 This minireview provides an overview of the state-of-the-art approaches for mild C-heteroatom bond formations highlights the developments in photoredox and nickel dual catalysis involving SET and energy transfer processes; photoexcited nickel cataylsis; electro and nickel dual catalysis; heterogeneous photoredox and nickel dual catalysis involving graphitic carbon nitride (mpg-CN), metal organic frameworks (MOFs) or semiconductor quantum dots (QDs); as well as more conventional zinc and nickel dual catalyzed reactions. Nickel 236-242 N-methylpurine DNA glycosylase Homo sapiens 376-379 32693207-0 2020 HLA-DR53 (DRB4*01) Associates with Nickel Sensitization. Nickel 35-41 major histocompatibility complex, class II, DR beta 4 Homo sapiens 10-14 32673675-0 2020 Cytochrome c oxidase oxygen reduction reaction induced by cytochrome c on nickel-coordination surfaces based on graphene oxide in suspension. Nickel 74-80 cytochrome c, somatic Equus caballus 58-70 32924694-0 2020 miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis. Nickel 16-22 microRNA 21a Mus musculus 0-6 33017144-3 2020 DFT calculations have been performed to investigate the ACS reaction mechanism starting from three different oxidation states (+2, +1, and 0) of Nip, the nickel proximal to [Fe4S4]. Nickel 154-160 acyl-CoA synthetase short chain family member 2 Homo sapiens 56-59 32897354-7 2020 Furthermore, by using a nickel-lipid containing peptide-based nanodiscs system, we studied the binding of Vav2-SH2 to the phosphorylated JM region of EphA2 on lipid membrane and uncovered a role of membrane environment in modulating this protein-protein recognition. Nickel 24-30 vav guanine nucleotide exchange factor 2 Homo sapiens 106-110 32897354-7 2020 Furthermore, by using a nickel-lipid containing peptide-based nanodiscs system, we studied the binding of Vav2-SH2 to the phosphorylated JM region of EphA2 on lipid membrane and uncovered a role of membrane environment in modulating this protein-protein recognition. Nickel 24-30 EPH receptor A2 Homo sapiens 150-155 33053778-1 2020 In the present study, the effect of post weld heat treatment (PWHT) on the microstructure and corrosion kinetics of butter welded Nickel Alloy 617 and 12Cr steel was investigated. Nickel 130-136 solute carrier family 35 member G1 Homo sapiens 36-40 32935698-3 2020 Herein, phosphorus-doping modulation is utilized to fabricate monoclinic P-CoMoO4 with optimized electron structure supported on nickel foam (P-CoMoO4/NF) for alkaline HER via a facile hydrothermal method, followed by low-temperature phosphidation. Nickel 129-135 neurofascin Homo sapiens 142-153 32298488-0 2020 TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells. Nickel 72-78 T cell receptor alpha variable 9-2 Homo sapiens 18-25 32298488-0 2020 TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells. Nickel 72-78 CD4 molecule Homo sapiens 88-91 32298488-2 2020 In vitro, CD4+ T cells from all donors respond to nickel but the involved alphabeta T cell receptor (TCR) repertoire has not been comprehensively analyzed. Nickel 50-56 CD4 molecule Homo sapiens 10-13 32298488-3 2020 METHODS: We introduce CD154 (CD40L) upregulation as a fast, unbiased, and quantitative method to detect nickel-specific CD4+ T cells ex vivo in blood of clinically characterized allergic and non-allergic donors. Nickel 104-110 CD40 ligand Homo sapiens 22-27 32298488-3 2020 METHODS: We introduce CD154 (CD40L) upregulation as a fast, unbiased, and quantitative method to detect nickel-specific CD4+ T cells ex vivo in blood of clinically characterized allergic and non-allergic donors. Nickel 104-110 CD40 ligand Homo sapiens 29-34 32298488-3 2020 METHODS: We introduce CD154 (CD40L) upregulation as a fast, unbiased, and quantitative method to detect nickel-specific CD4+ T cells ex vivo in blood of clinically characterized allergic and non-allergic donors. Nickel 104-110 CD4 molecule Homo sapiens 29-32 32298488-8 2020 Among nickel-specific CD4+ T cells of allergic and non-allergic donors, TCRs expressing the alpha-chain segment TRAV9-2 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) were highly overrepresented. Nickel 6-12 CD4 molecule Homo sapiens 22-25 32298488-8 2020 Among nickel-specific CD4+ T cells of allergic and non-allergic donors, TCRs expressing the alpha-chain segment TRAV9-2 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) were highly overrepresented. Nickel 6-12 Fc gamma receptor and transporter Homo sapiens 92-103 32298488-9 2020 CONCLUSIONS: Induced CD154 expression represents a reliable method to study nickel-specific CD4+ T cells. Nickel 76-82 CD40 ligand Homo sapiens 21-26 32298488-9 2020 CONCLUSIONS: Induced CD154 expression represents a reliable method to study nickel-specific CD4+ T cells. Nickel 76-82 CD4 molecule Homo sapiens 92-95 32700830-3 2020 In this study, the rhesus sodium/iodide symporter (NIS) gene was incorporated into rhesus macaque induced pluripotent stem cells (RhiPSCs) via CRISPR/Cas9. Nickel 51-54 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 26-49 32942330-10 2020 Release of further metals such as tantalum, niobium, nickel, vanadium and zirconium from hip and knee replacement implants has been described occasionally, but systemic effects of respective long-term exposure scenarios are unknown. Nickel 53-59 hedgehog interacting protein Homo sapiens 89-92 32661532-4 2020 MTF-1 biomarker genes were identified that exhibited consistent, robust expression across 10 microarray comparisons examining the effects of metals (zinc, nickel, lead, arsenic, mercury, and silver) on gene expression in human cells. Nickel 155-161 metal regulatory transcription factor 1 Homo sapiens 0-5 33102712-3 2020 The Memokath stent (Pnn Medical A/S, Kvistgaard, Denmark) is manufactured from a biocompatible alloy of nickel and titanium and known to be the most popular in this field. Nickel 104-110 pinin, desmosome associated protein Homo sapiens 20-23 32984724-1 2020 Nickel catalysts represent a low cost and environmentally friendly alternative to palladium-based catalytic systems for Suzuki-Miyaura cross-coupling (SMC) reactions. Nickel 0-6 dymeclin Homo sapiens 120-155 32805116-0 2020 Small Phosphine Ligands Enable Selective Oxidative Addition of Ar-O over Ar-Cl Bonds at Nickel(0). Nickel 88-94 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 63-67 32899780-0 2020 Spinel of Nickel-Cobalt Oxide with Rod-Like Architecture as Electrocatalyst for Oxygen Evolution Reaction. Nickel 10-16 kinetochore associated 1 Homo sapiens 35-38 32819609-3 2020 Part 2: The recombinant MUC5AC was expressed in HEK293 cells and purified by nickel column chromatography. Nickel 77-83 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 24-30 32884021-0 2020 Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Nickel 92-98 suprabasin Mus musculus 0-10 32884021-0 2020 Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Nickel 109-115 suprabasin Mus musculus 0-10 32884021-1 2020 Suprabasin (SBSN) is expressed not only in epidermis but also in epithelial cells of the upper digestive tract where metals such as nickel are absorbed. Nickel 132-138 suprabasin Mus musculus 0-10 32884021-1 2020 Suprabasin (SBSN) is expressed not only in epidermis but also in epithelial cells of the upper digestive tract where metals such as nickel are absorbed. Nickel 132-138 suprabasin Mus musculus 12-16 32884021-6 2020 The blood nickel level after oral feeding of nickel was significantly higher in Sbsn-/- mice than in WT mice, and CHS to nickel was elevated in Sbsn-/- mice under nickel-loading condition. Nickel 10-16 suprabasin Mus musculus 80-84 32884021-6 2020 The blood nickel level after oral feeding of nickel was significantly higher in Sbsn-/- mice than in WT mice, and CHS to nickel was elevated in Sbsn-/- mice under nickel-loading condition. Nickel 45-51 suprabasin Mus musculus 80-84 32884021-6 2020 The blood nickel level after oral feeding of nickel was significantly higher in Sbsn-/- mice than in WT mice, and CHS to nickel was elevated in Sbsn-/- mice under nickel-loading condition. Nickel 45-51 suprabasin Mus musculus 80-84 32884021-6 2020 The blood nickel level after oral feeding of nickel was significantly higher in Sbsn-/- mice than in WT mice, and CHS to nickel was elevated in Sbsn-/- mice under nickel-loading condition. Nickel 45-51 suprabasin Mus musculus 80-84 32884021-7 2020 Our study suggests that the completely SBSN deficient mice retain normal barrier function, but harbor abnormal upper digestive tract epithelium that promotes nickel absorption and high CHS to nickel, sharing the features of intrinsic AD. Nickel 158-164 suprabasin Mus musculus 39-43 32884021-7 2020 Our study suggests that the completely SBSN deficient mice retain normal barrier function, but harbor abnormal upper digestive tract epithelium that promotes nickel absorption and high CHS to nickel, sharing the features of intrinsic AD. Nickel 192-198 suprabasin Mus musculus 39-43 32402875-0 2020 Effect and mechanism of PI3K/AKT/mTOR signaling pathway in the apoptosis of GC-1 cells induced by nickel nanoparticles. Nickel 98-104 thymoma viral proto-oncogene 1 Mus musculus 29-32 32402875-0 2020 Effect and mechanism of PI3K/AKT/mTOR signaling pathway in the apoptosis of GC-1 cells induced by nickel nanoparticles. Nickel 98-104 mechanistic target of rapamycin kinase Mus musculus 33-37 32631048-4 2020 An optimal nickel foam supported CCCO-P2 NSs (Ni@CCCO-P2, 5 atom % Ca-doped) electrode requires low overpotential of 470 mV to afford the current density of 10 mA cm-2 and small Tafel slope of 96.5 mV dec-1. Nickel 11-17 deleted in esophageal cancer 1 Homo sapiens 201-206 32883042-0 2020 Thermal Barrier Stability and Wear Behavior of CVD Deposited Aluminide Coatings for MAR 247 Nickel Superalloy. Nickel 92-98 interferon regulatory factor 1 Homo sapiens 84-87 32883042-3 2020 These coatings were characterized by beneficial mechanical features including thermal stability, wear resistance and good adhesion strength to MAR 247 nickel superalloy substrate. Nickel 151-157 interferon regulatory factor 1 Homo sapiens 143-146 32859031-1 2020 The manufacturing of parts from nickel-based superalloy Alloy 247LC by laser powder bed fusion (L-PBF) is challenging, primarily owing to the alloy"s susceptibility to cracks. Nickel 32-38 PTTG1 interacting protein Homo sapiens 98-101 32806046-4 2020 Here, we present a versatile manufacturing process that utilizes tar as both a light absorber and antioxidant binder to sinter thin films of aluminum, copper, nickel, molybdenum, and tungsten powder using a low power (<2W) CO2 laser in air. Nickel 159-165 RNA binding motif protein 8A Homo sapiens 65-68 32340008-5 2020 Taking advantage of these features, an ASC is constructed by using NiCoSe2 on nickel foam as positive electrode and AC electrode as negative electrode with 3 M KOH as electrolyte. Nickel 78-84 PYD and CARD domain containing Homo sapiens 39-42 32696774-5 2020 Here, we found that the level of adsorbed heat shock protein 90 kDa alpha class B member 1 (Hsp90ab1) by the denatured protein in iron-cobalt-nickel alloy NPs (FeCoNi NPs) and iron oxide NPs (Fe3O4 NPs) was correlated with circular dichroism (CD) analysis and 1-anilinonaphthalene-8-sulfonate (ANS) analysis. Nickel 142-148 heat shock protein 90 alpha family class B member 1 Homo sapiens 92-100 32627875-1 2020 High-nickel LiNi1- x - y Mnx Coy O2 (NMC) and LiNi1- x - y Cox Aly O2 (NCA) are the cathode materials of choice for next-generation high-energy lithium-ion batteries. Nickel 5-11 keratin 86 Homo sapiens 25-28 32650180-9 2020 Nickel complexes were studied against enzymes that are human carbonic anhydrase isozyme I for ID 2CAB (hCA I), butyrylcholinesterase for ID 1P0I (BChE), and acetylcholinesterase for ID 1EEA (AChE), respectively. Nickel 0-6 carbonic anhydrase 1 Homo sapiens 98-101 32650180-9 2020 Nickel complexes were studied against enzymes that are human carbonic anhydrase isozyme I for ID 2CAB (hCA I), butyrylcholinesterase for ID 1P0I (BChE), and acetylcholinesterase for ID 1EEA (AChE), respectively. Nickel 0-6 butyrylcholinesterase Homo sapiens 146-150 32650180-9 2020 Nickel complexes were studied against enzymes that are human carbonic anhydrase isozyme I for ID 2CAB (hCA I), butyrylcholinesterase for ID 1P0I (BChE), and acetylcholinesterase for ID 1EEA (AChE), respectively. Nickel 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 32558829-1 2020 An unprecedented nickel-catalyzed hydroarylative and hydroalkenylative cyclization of unsymmetrically substituted 1,6-dienes with organoboronic acid was developed by using MeOH as the hydrogen source and employing commercially available Ni(eta2-1,5-cyclooctadiene)2 as the catalyst. Nickel 17-23 DNA polymerase iota Homo sapiens 240-244 32491839-4 2020 Overall, the most widely used nickel precatalyst with free bidentate phosphines is Ni(cod)2, which accounts for ~50% of the reports surveyed, distantly followed by Ni(acac)2 and Ni(OAc)2, which account for ~10% each. Nickel 30-36 COD2 Homo sapiens 83-91 32573236-1 2020 A highly enantioselective and straightforward synthetic procedure to chiral 3-hydroxy-2,3-dihydrobenzofurans has been developed by nickel/bisoxazoline-catalyzed intramolecular asymmetric addition of aryl halides to unactivated ketones, giving 2,3-dihydrobenzofurans with a chiral tertiary alcohol at the C-3 position in good yields and excellent enantioselectivities (up to 92% yield and 98% ee). Nickel 131-137 complement C3 Homo sapiens 304-307 32573210-1 2020 Nickel anions [(MeCN)Ni(CF3)3]- and [Ni(CF3)4]2- were prepared by the formal addition of 3 and 4 equiv, respectively, of AgCF3 to [(dme)NiBr2] in the presence of the [PPh4]+ counterion. Nickel 0-6 potassium two pore domain channel subfamily K member 3 Homo sapiens 167-171 32635594-1 2020 The flow stress behaviour of a directionally solidified nickel-base superalloy, MAR-M247, is presented through the combination of experiments and crystal-plasticity simulations. Nickel 56-62 interferon regulatory factor 1 Homo sapiens 80-83 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 BCL2 antagonist/killer 1 Homo sapiens 61-64 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 cytochrome c, somatic Homo sapiens 66-78 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 caspase 3 Homo sapiens 80-89 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 caspase 9 Homo sapiens 91-100 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 DNA damage inducible transcript 3 Homo sapiens 118-126 31872268-9 2020 CONCLUSION: In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Nickel 84-90 microRNA 21 Homo sapiens 155-161 31872268-9 2020 CONCLUSION: In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Nickel 84-90 microRNA 146a Homo sapiens 163-171 31872268-9 2020 CONCLUSION: In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Nickel 84-90 microRNA 155 Homo sapiens 176-183 32895213-5 2020 The fusion protein Trx-MVF-HER3 I was purified using nickel ion affinity chromatography, and the purified protein was digested by enterokinase to remove Trx tag. Nickel 53-59 thioredoxin Homo sapiens 19-22 32279993-3 2020 Later, some metal ions, including nickel ion (Ni2+), are also indicated to be OGR1 ligands. Nickel 34-40 G protein-coupled receptor 68 Homo sapiens 78-82 32582232-0 2020 Elevated Expression of Vacuolar Nickel Transporter Gene IREG2 Is Associated With Reduced Root-to-Shoot Nickel Translocation in Noccaea japonica. Nickel 32-38 iron regulated 2 Arabidopsis thaliana 56-61 32566089-7 2020 N-Acetylcysteine (NAC) manifested similar effects as melatonin in scavenging ROS, maintaining prolyl-hydroxylase activity, and mitigating HIF-1alpha transcriptional activity in nickel-exposed cells. Nickel 177-183 hypoxia inducible factor 1 subunit alpha Homo sapiens 138-148 32378404-4 2020 A molybdenum polysulfide deposited nickel-iron bimetal Prussian blue analog-based hollow nanocages (Nanocages) with peroxidase, catalase and laccase mimicking activity was synthesized. Nickel 35-41 catalase Rattus norvegicus 128-136 32168396-2 2020 Here we report that the nickel congener, [Ni3 (dpa)4 (CH3 CN)2 ]2+ , can likewise be resolved using AsT. Nickel 24-30 solute carrier family 17 member 5 Homo sapiens 100-103 32171946-0 2020 Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-beta1/Smad2/Smad3 signaling. Nickel 49-55 transforming growth factor beta 1 Homo sapiens 144-153 32171946-0 2020 Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-beta1/Smad2/Smad3 signaling. Nickel 49-55 SMAD family member 2 Homo sapiens 154-159 32171946-0 2020 Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-beta1/Smad2/Smad3 signaling. Nickel 49-55 SMAD family member 3 Homo sapiens 160-165 32134556-8 2020 The introduction of the nickel and iron magnetic polymers increased the pressure of collapse substantially (7.38-17.51 cmH2 O). Nickel 24-30 troponin T2, cardiac type Homo sapiens 119-123 32566089-0 2020 Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1alpha/miR210/ISCU Axis Activation. Nickel 22-28 hypoxia inducible factor 1 subunit alpha Homo sapiens 81-91 32566089-0 2020 Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1alpha/miR210/ISCU Axis Activation. Nickel 22-28 microRNA 210 Homo sapiens 92-98 32566089-0 2020 Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1alpha/miR210/ISCU Axis Activation. Nickel 22-28 iron-sulfur cluster assembly enzyme Homo sapiens 99-103 32566089-1 2020 Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 122-153 32566089-1 2020 Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1alpha (HIF-1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 155-165 32029268-4 2020 The oriented immobilization of PNGase F on magnetic particles utilizes the affinity of its co-expressed His-tag towards iminodiacetic acid-Nickel modified magnetic particles. Nickel 139-145 N-glycanase 1 Homo sapiens 31-37 32509491-2 2020 In this work, nickel nanoparticles (from Ni(COD)2) were supported on CTF-1 materials, which were synthesized from 1,4-dicyanobenzene at 400 C and 600 C by the ionothermal method. Nickel 14-20 COD2 Homo sapiens 41-49 32509491-2 2020 In this work, nickel nanoparticles (from Ni(COD)2) were supported on CTF-1 materials, which were synthesized from 1,4-dicyanobenzene at 400 C and 600 C by the ionothermal method. Nickel 14-20 cardiotrophin 1 Homo sapiens 69-74 32509491-5 2020 Ni/CTF-1-600 displays an OER catalytic activity comparable with many nickel-based electrocatalysts and is a potential candidate for OER. Nickel 69-75 cardiotrophin 1 Homo sapiens 3-8 32278399-0 2020 Multicomponent nanohybrids of nickel/ferric oxides and nickel cobaltate spinel derived from the MOF-on-MOF nanostructure as efficient scaffolds for sensitively determining insulin. Nickel 55-61 insulin Homo sapiens 172-179 32065839-1 2020 We report that Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone), an air-stable 18-electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel-catalyzed synthetic methods from the literature. Nickel 194-200 retinitis pigmentosa GTPase regulator Homo sapiens 28-35 31943712-0 2020 Resveratrol protects human bronchial epithelial cells against nickel-induced toxicity via suppressing p38 MAPK, NF-kappaB signaling, and NLRP3 inflammasome activation. Nickel 62-68 NLR family pyrin domain containing 3 Homo sapiens 137-142 31943712-5 2020 The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein. Nickel 24-30 tumor necrosis factor Homo sapiens 155-182 31943712-5 2020 The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein. Nickel 24-30 interleukin 1 beta Homo sapiens 184-206 31943712-5 2020 The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein. Nickel 24-30 interleukin 6 Homo sapiens 208-212 31943712-5 2020 The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein. Nickel 24-30 C-X-C motif chemokine ligand 8 Homo sapiens 214-218 31943712-6 2020 Western blot analysis showed that nickel activated p38 mitogen-activated protein kinase (MAPK), nuclear factor-kappa B, and nucleotide-binding oligomerization domain-like receptor pyrin-domain-containing protein 3 pathways, while resveratrol could reverse these effects. Nickel 34-40 mitogen-activated protein kinase 14 Homo sapiens 51-87 33912790-7 2020 Only antibodies competed with ACE2 can bind to the free RBD-His in the supernatant and be subsequently separated by the nickel-nitrilotriacetic acid magnetic beads. Nickel 120-126 angiotensin converting enzyme 2 Homo sapiens 30-34 31999038-3 2020 Both the NiO5 single-atom active centers and nanotube framework endow the Ni/S/C ternary composite with accelerated reaction kinetics for potassium-ion storage. Nickel 9-13 solute carrier family 5 member 5 Homo sapiens 74-78 32195579-0 2020 On The Nature of C(sp3)-C(sp2) Bond Formation in Nickel-Catalyzed Tertiary Radical Cross-Couplings: A Case Study of Ni/Photoredox Catalytic Cross-Coupling of Alkyl Radicals and Aryl Halides. Nickel 49-55 Sp2 transcription factor Homo sapiens 24-29 31993586-9 2020 The Ni6 clusters show high sensing performance for AA with a wide linear range (1-3212 muM) and a low detection limit of 0.1 muM (S/N = 3). Nickel 4-7 latexin Homo sapiens 87-90 31993586-9 2020 The Ni6 clusters show high sensing performance for AA with a wide linear range (1-3212 muM) and a low detection limit of 0.1 muM (S/N = 3). Nickel 4-7 latexin Homo sapiens 125-128 32566089-8 2020 Our results indicated that ROS generation contributed to nickel-caused HIF-1alpha stabilization and downstream signal activation. Nickel 57-63 hypoxia inducible factor 1 subunit alpha Homo sapiens 71-81 32207613-0 2020 The Role of the Cysteine Fragments of the Nickel Binding Loop in the Activity of the Ni(II)-Containing SOD Enzyme. Nickel 42-48 superoxide dismutase 1 Homo sapiens 103-106 32207613-1 2020 Detailed equilibrium, spectroscopic, and SOD activity studies are reported on nickel(II) complexes formed with the N-terminally free HHDLPCGVY-NH2 (NiSODHH) and HCDLPHGVY-NH2 (NiSODHC) peptides mimicking the nickel binding loop in NiSOD. Nickel 78-84 superoxide dismutase 1 Homo sapiens 41-44 30674994-3 2020 To refine pre-clinical BLI methods and circumvent these limitations, we compared and ultimately combined BLI with tomographic, quantitative imaging of the sodium iodide symporter (NIS). Nickel 180-183 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 155-178 32302194-0 2020 Two-Color Soft X-Ray Lasing in a High-Density Nickel-like Krypton Plasma. Nickel 46-52 POC1 centriolar protein A Homo sapiens 10-14 31978792-2 2020 Herein, Cu(NiCo)2S4/Ni3S4, a three-dimensional (3D) hierarchical hollow heterostructured electrode material, is designed by etching the well-defined bimetal organic framework (MOF) via sequential in-situ ion-exchange processes. Nickel 8-19 lysine acetyltransferase 8 Homo sapiens 176-179 31612419-11 2020 In an in vivo orthotopic model, the enhancement of miR-875-5p led to the reduction of NIS expression and radioiodine uptake in the thyroid tumors. Nickel 86-89 microRNA 875 Homo sapiens 51-58 31978792-2 2020 Herein, Cu(NiCo)2S4/Ni3S4, a three-dimensional (3D) hierarchical hollow heterostructured electrode material, is designed by etching the well-defined bimetal organic framework (MOF) via sequential in-situ ion-exchange processes. Nickel 20-25 lysine acetyltransferase 8 Homo sapiens 176-179 32034695-0 2020 Nickel-Induced Developmental Neurotoxicity in C. elegans Includes Cholinergic, Dopaminergic and GABAergic Degeneration, Altered Behaviour, and Increased SKN-1 Activity. Nickel 0-6 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 153-158 32149521-1 2020 Density functional theory mechanistic study of the nickel-catalyzed reductive alkyne-alkyne cyclodimerization with CH3OH/BEt3 unveils that, after forming a nickel-alkyne pi complex, the reaction prefers outer-sphere proton transfer rather than the common alkyne-alkyne oxidative cyclization. Nickel 51-57 trafficking protein particle complex subunit 3 Homo sapiens 121-125 31928162-15 2020 Increased endogenous NIS expression was associated with the inhibition of PI3K/Akt and MAPK signaling pathways. Nickel 21-24 AKT serine/threonine kinase 1 Homo sapiens 79-82 31562928-6 2020 After the recovery of the electroactive consortium activity, the MFC-based biosensors were shown to be sensitive towards Ni(II) and Cr(III), at concentrations above 2 mg L-1. Nickel 121-127 immunoglobulin kappa variable 1-16 Homo sapiens 170-173 32149521-1 2020 Density functional theory mechanistic study of the nickel-catalyzed reductive alkyne-alkyne cyclodimerization with CH3OH/BEt3 unveils that, after forming a nickel-alkyne pi complex, the reaction prefers outer-sphere proton transfer rather than the common alkyne-alkyne oxidative cyclization. Nickel 156-162 trafficking protein particle complex subunit 3 Homo sapiens 121-125 31877421-4 2020 A novel binder-free electrode for OER activity has been prepared by coating a 3D FTO/NG onto nickel foam (NF). Nickel 93-99 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 81-84 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 93-97 CWC22 spliceosome associated protein homolog Homo sapiens 84-87 31751971-0 2020 Influence of SiC and TiC nanoparticles reinforcement on the microstructure, tribological, and scratch resistance behavior of electroless Ni-P coatings. Nickel 137-141 pleckstrin and Sec7 domain containing 4 Homo sapiens 21-24 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 101-105 CWC22 spliceosome associated protein homolog Homo sapiens 110-113 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 101-105 deleted in esophageal cancer 1 Homo sapiens 361-366 32008081-6 2020 The linear dynamic ranges obtained for Ni(II) and Co(II) were 1.0-30 and 0.50-20 mug L-1, respectively. Nickel 39-45 L1 cell adhesion molecule Homo sapiens 85-88 31818622-10 2020 Moreover, plasma CC16 decreased monotonically with increasing quartiles of urinary vanadium, nickel or antimony. Nickel 93-99 secretoglobin family 1A member 1 Homo sapiens 17-21 31818622-11 2020 Mediation analyses found that CC16 mediated the associations between urinary metals and FeNO by 5.64%, 39.06% and 25.18% for vanadium, nickel and antimony respectively. Nickel 135-141 secretoglobin family 1A member 1 Homo sapiens 30-34 31818622-13 2020 General population with lower plasma CC16 concentration is more likely to suffer from airway inflammation when exposed to high levels of vanadium, nickel or antimony. Nickel 147-153 secretoglobin family 1A member 1 Homo sapiens 37-41 32004873-5 2020 The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) and is depleted by >50% in bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, and other organic compounds. Nickel 135-141 nucleophosmin 1 Homo sapiens 4-7 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 93-97 CWC22 spliceosome associated protein homolog Homo sapiens 110-113 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 93-97 CWC22 spliceosome associated protein homolog Homo sapiens 110-113 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 101-105 CWC22 spliceosome associated protein homolog Homo sapiens 84-87 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 101-105 CWC22 spliceosome associated protein homolog Homo sapiens 110-113 32043855-4 2020 By introducing lithium deficiency to tune the valence state of transition metals in NCM from Ni2+ to Ni3+, DO-NCM exhibits the best catalytic activity with respect to the lowest onset potential (~1.48 V) and Tafel slope (~85.6 mV dec-1), whereas HT-NCM exhibits the worst catalytic activity with the highest onset potential (~1.63 V) and Tafel slope (~241.8 mV dec-1). Nickel 101-105 deleted in esophageal cancer 1 Homo sapiens 230-235 31881105-1 2020 The analog methanobactin (amb) peptide with the sequence ac-His1 -Cys2 -Gly3 -Pro4 -Tyr5 -His6 -Cys7 (amb5A ) will bind the metal ions of zinc, nickel, and copper. Nickel 144-150 viral integration site 1 Homo sapiens 60-64 32027803-2 2020 Herein, we present a facile route to synthesize low Pt-content ternary PtNiCu nanostructures with hollow interior and accessible surfaces (H-PtNiCu-AAT NPs) as enhanced multifunctional electrocatalysts. Nickel 71-77 serpin family A member 1 Homo sapiens 148-151 31750920-0 2020 Nickel Toxicity Targets Cell Wall-Related Processes and PIN2-Mediated Auxin Transport to Inhibit Root Elongation and Gravitropic Responses in Arabidopsis. Nickel 0-6 Auxin efflux carrier family protein Arabidopsis thaliana 56-60 31892076-6 2020 The detection limits were 2.66-27.9 ng mL-1 for Ni2+, Co2+, Cu2+, Hg2+ and Cd2+. Nickel 48-52 L1 cell adhesion molecule Mus musculus 39-43 32027803-2 2020 Herein, we present a facile route to synthesize low Pt-content ternary PtNiCu nanostructures with hollow interior and accessible surfaces (H-PtNiCu-AAT NPs) as enhanced multifunctional electrocatalysts. Nickel 139-147 serpin family A member 1 Homo sapiens 148-151 31590087-2 2020 In this study, high-performance g-C3N4/NiO heterojunctions were fabricated to degrade 2-chlorodibenzo-p-dioxin (2-CDD) under ultraviolet-visible (UV-vis) light illumination. Nickel 39-42 natriuretic peptide A Homo sapiens 114-117 32068765-6 2020 We first considered the direct chlorination of NiS by Cl2, which was suggested to form by the reaction between NH4Cl and SO3 catalyzed by a metal oxide. Nickel 47-50 endogenous retrovirus group W member 5 Homo sapiens 54-57 32017543-6 2020 Subsequently, the resulting remote carbon-centered radicals formed by C-C cleavage merge with the nickel catalytic cycle to create the challenging C(sp3)-C(sp2) bonds. Nickel 98-104 Sp2 transcription factor Homo sapiens 154-159 31590087-5 2020 After comparison, the g-C3N4/NiO (4:6) showed optimal dechlorination performance such that 70.4% of 2-CDD was removed within 8 h and 52.3% of 2-CDD was transformed to dibenzo-p-dioxin (DD), about fourfold higher than the pristine g-C3N4. Nickel 29-32 natriuretic peptide A Homo sapiens 144-147 31994577-0 2020 An Fe-V@NiO heterostructure electrocatalyst towards the oxygen evolution reaction. Nickel 8-11 FEV transcription factor, ETS family member Homo sapiens 3-7 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 74-77 FEV transcription factor, ETS family member Homo sapiens 104-108 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 74-77 FEV transcription factor, ETS family member Homo sapiens 139-143 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 126-132 FEV transcription factor, ETS family member Homo sapiens 104-108 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 126-132 FEV transcription factor, ETS family member Homo sapiens 139-143 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 144-147 FEV transcription factor, ETS family member Homo sapiens 104-108 31994577-2 2020 In the present work, we proposed a facile strategy to construct ultrathin NiO nanosheets decorated with Fe-V nanoparticles on nickel foam (Fe-V@NiO/NF) for use as an OER electrocatalyst. Nickel 144-147 FEV transcription factor, ETS family member Homo sapiens 139-143 31994577-3 2020 Due to the 3D rational configuration, the Fe-V@NiO/NF with a heterostructure shows excellent electrocatalytic activity towards the OER. Nickel 47-50 FEV transcription factor, ETS family member Homo sapiens 42-46 31967118-1 2020 The exquisite combination of hetreometallic [TbIIINiII(COO)3(H2O)] clusters with a designed hexatopic ligand generates one highly robust three-dimensional heterometallic TbIII/NiII-organic framework material {[TbNi(HTDP)(H2O)] 3DMF 2H2O}n (NUC-2; H6TDP = 2,4,6-tri(2,4-dicarboxyphenyl)pyridine). Nickel 50-54 cell division cycle 27 Homo sapiens 240-245 31968163-0 2020 Influences of Calcination Atmosphere on Nickel Catalyst Supported on Mesoporous Graphitic Carbon Nitride (mpg-C3N4) Thin Sheets for CO Methanation. Nickel 40-46 N-methylpurine DNA glycosylase Homo sapiens 106-109 31968163-1 2020 Nickel (Ni) catalysts supported on mesoporous graphitic carbon nitride (mpg-C3N4) were synthesized through simple impregnation method with air and nitrogen calcination atmosphere for CO methanation. Nickel 0-6 N-methylpurine DNA glycosylase Homo sapiens 72-75 31968163-10 2020 Therefore, mpg-C3N4 thin sheets can be an interesting support for nickel catalyst for COx methanation. Nickel 66-72 N-methylpurine DNA glycosylase Homo sapiens 11-14 31743497-3 2020 The incorporation of a higher amount of nickel in NiCl@RIO-12 consistently led to a lower BET surface area. Nickel 40-46 delta/notch like EGF repeat containing Homo sapiens 90-93 31743497-3 2020 The incorporation of a higher amount of nickel in NiCl@RIO-12 consistently led to a lower BET surface area. Nickel 50-54 delta/notch like EGF repeat containing Homo sapiens 90-93 31942885-7 2020 The proper alloying ratio leads to the suitable modification of the electronic structure of Ni, which promotes the MOR catalytic reaction on the NiCu alloy. Nickel 145-149 opioid receptor mu 1 Homo sapiens 115-118 31942885-8 2020 The NiCu alloy catalyst exhibits a mass current density of 1028 mA mgmetal-1 for the MOR at 1.55 V (vs. RHE), which is among the best values obtained from similarly prepared Ni-based catalysts. Nickel 4-8 opioid receptor mu 1 Homo sapiens 85-88 31940170-3 2020 The obtained Ni3N/NF displays a high HER activity with a small overpotential of 44 mV and a low Tafel slope of 46 mV dec-1, which is competitive to Pt/C catalyst. Nickel 13-17 deleted in esophageal cancer 1 Homo sapiens 117-122 31860738-4 2020 The dynamic processes can be blocked by coordination to {W(CO)5} fragments, leading to the complexes [(Cp*Fe)(Cp"""Co)(micro3,eta5:eta4:eta1-P5){W(CO)5}] (2a), [(Cp*Fe)(Cp"""Co) (micro4,eta5:eta4:eta1:eta1-P5){(W(CO)5)2}] (2b) and [(Cp"""Co)(Cp"""Ni)(micro3,eta3:eta2:eta1-P3){W(CO)5}] (4), respectively. Nickel 242-249 secreted phosphoprotein 1 Homo sapiens 136-140 31860738-5 2020 The thermolysis of 3 leads to the tetrahedrane complex [(Cp"""Ni)2(micro,eta2:eta2-P)2] (5). Nickel 57-64 DNA polymerase iota Homo sapiens 73-77 31860738-5 2020 The thermolysis of 3 leads to the tetrahedrane complex [(Cp"""Ni)2(micro,eta2:eta2-P)2] (5). Nickel 57-64 DNA polymerase iota Homo sapiens 78-82 32064409-0 2020 Using Smartphone APP To Determine the CN- Concentration Quantitatively in Tap Water: Synthesis of the Naked-Eye Colorimetric Chemosensor for CN- and Ni2+ Based on Benzothiazole. Nickel 149-153 nuclear RNA export factor 1 Homo sapiens 74-77 31590087-5 2020 After comparison, the g-C3N4/NiO (4:6) showed optimal dechlorination performance such that 70.4% of 2-CDD was removed within 8 h and 52.3% of 2-CDD was transformed to dibenzo-p-dioxin (DD), about fourfold higher than the pristine g-C3N4. Nickel 29-32 natriuretic peptide A Homo sapiens 102-105 31985171-4 2020 Particularly, the optimized 10 at% Ni-doped CoPi nanoflakes (denoted as Ni10-CoPi) deliver a low overpotential at 10 mA cm-2 (320 mV), small Tafel slope (44.5 mV dec-1 ), and high stability for OER in 1.0 m KOH solution, which is comparable to the state-of-the-art RuO2 tested in the same condition (overpotential: 327 mV at 10 mA cm-2 , Tafel slope: 73.7 mV dec-1 ). Nickel 72-81 deleted in esophageal cancer 1 Homo sapiens 162-167 31985171-4 2020 Particularly, the optimized 10 at% Ni-doped CoPi nanoflakes (denoted as Ni10-CoPi) deliver a low overpotential at 10 mA cm-2 (320 mV), small Tafel slope (44.5 mV dec-1 ), and high stability for OER in 1.0 m KOH solution, which is comparable to the state-of-the-art RuO2 tested in the same condition (overpotential: 327 mV at 10 mA cm-2 , Tafel slope: 73.7 mV dec-1 ). Nickel 72-81 deleted in esophageal cancer 1 Homo sapiens 359-364 32001713-6 2020 As a result, the carbon doped NiO catalyst achieves an ultralow overpotential of 27 mV at 10 mA cm-2, and a low Tafel slope of 36 mV dec-1, representing the best performance among the state-of-the-art NiO catalysts. Nickel 30-33 deleted in esophageal cancer 1 Homo sapiens 133-138 31904031-1 2020 Controlled partial decomposition of 2-selenonicotinic acid in the presence of Co2+ or Ni2+ resulted in the in situ formation of an unusual MOF based on triselenane ligands (RSeSeSeR) coordinated to M2+ centers as NSeN-pincers. Nickel 86-90 lysine acetyltransferase 8 Homo sapiens 139-142 32072787-11 2020 Next, the CS1-Fc fusion protein was purified by nickel column. Nickel 48-54 SLAM family member 7 Homo sapiens 10-13 32031844-1 2020 NiNb_{2}O_{6} is an almost ideal realization of a 1D spin-1 ferromagnetic Heisenberg chain compound with weak unidirectional anisotropy. Nickel 0-4 spindlin 1 Homo sapiens 53-59 31903458-7 2020 In addition, the as-assembled flexible all-solid-state ASC device (NiMn-G-LDH@NiCo2S4@CFC//AC) is capable of working at various bending angles and exhibits an impressive energy density of 60.3 W h kg-1 at a power density of 375 W kg-1, as well as a superior cycling stability of 86.4% after 10 000 cycles. Nickel 67-73 PYD and CARD domain containing Homo sapiens 55-58 31903458-7 2020 In addition, the as-assembled flexible all-solid-state ASC device (NiMn-G-LDH@NiCo2S4@CFC//AC) is capable of working at various bending angles and exhibits an impressive energy density of 60.3 W h kg-1 at a power density of 375 W kg-1, as well as a superior cycling stability of 86.4% after 10 000 cycles. Nickel 78-85 PYD and CARD domain containing Homo sapiens 55-58 31907496-3 2020 In addition, the corresponding solid-state CoNi2S4//AC HSC could achieve a high energy density of 35.8 W h kg-1 at a power density of 800.0 W kg-1, with nearly no change when tested at 0 C and 50 C, and possessed excellent long-term electrochemical cycling stability of 132.3% after 50 000 cycles; the solid-state hybrid supercapacitor using biomass-derived carbon (BC) as the negative electrode (CoNi2S4//BC HSC) could also deliver a high energy density of 38.9 W h kg-1 at a power density of 850.0 W kg-1 and the specific capacitance retention was 101.2% after cycling for 50 000 times. Nickel 43-50 fucosyltransferase 1 (H blood group) Homo sapiens 55-58 31907496-3 2020 In addition, the corresponding solid-state CoNi2S4//AC HSC could achieve a high energy density of 35.8 W h kg-1 at a power density of 800.0 W kg-1, with nearly no change when tested at 0 C and 50 C, and possessed excellent long-term electrochemical cycling stability of 132.3% after 50 000 cycles; the solid-state hybrid supercapacitor using biomass-derived carbon (BC) as the negative electrode (CoNi2S4//BC HSC) could also deliver a high energy density of 38.9 W h kg-1 at a power density of 850.0 W kg-1 and the specific capacitance retention was 101.2% after cycling for 50 000 times. Nickel 43-50 fucosyltransferase 1 (H blood group) Homo sapiens 411-414 31907496-3 2020 In addition, the corresponding solid-state CoNi2S4//AC HSC could achieve a high energy density of 35.8 W h kg-1 at a power density of 800.0 W kg-1, with nearly no change when tested at 0 C and 50 C, and possessed excellent long-term electrochemical cycling stability of 132.3% after 50 000 cycles; the solid-state hybrid supercapacitor using biomass-derived carbon (BC) as the negative electrode (CoNi2S4//BC HSC) could also deliver a high energy density of 38.9 W h kg-1 at a power density of 850.0 W kg-1 and the specific capacitance retention was 101.2% after cycling for 50 000 times. Nickel 399-406 fucosyltransferase 1 (H blood group) Homo sapiens 55-58 31912073-3 2020 In 1.0 M KOH, only an overpotential of 172 mV (vs. RHE) at 100 mA cm-2 is required for S doped NiCoP nanowires on CFP, and the turnover frequency (TOF) is 1.71 times that of NiCoP at an overpotential of 100 mV, indicating its superior intrinsic activity. Nickel 95-100 complement factor properdin Homo sapiens 114-117 32014793-0 2020 Gene (HPRT) and chromosomal (MN) mutations of nickel metal powder in V79 Chinese hamster cells. Nickel 46-52 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 6-10 31963541-0 2020 Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1alpha for Lung Tumorigenesis. Nickel 20-26 angiopoietin like 4 Homo sapiens 36-63 31963541-0 2020 Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1alpha for Lung Tumorigenesis. Nickel 20-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 79-89 31963541-8 2020 In conclusion, the increased presence of ANGPTL4 due to HIF-1alpha accumulation that is caused by nickel in lung cells may be one mechanism by which nickel exposure contributes to lung cancer progression. Nickel 98-104 angiopoietin like 4 Homo sapiens 41-48 31963541-8 2020 In conclusion, the increased presence of ANGPTL4 due to HIF-1alpha accumulation that is caused by nickel in lung cells may be one mechanism by which nickel exposure contributes to lung cancer progression. Nickel 98-104 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-66 31963541-8 2020 In conclusion, the increased presence of ANGPTL4 due to HIF-1alpha accumulation that is caused by nickel in lung cells may be one mechanism by which nickel exposure contributes to lung cancer progression. Nickel 149-155 angiopoietin like 4 Homo sapiens 41-48 31963541-8 2020 In conclusion, the increased presence of ANGPTL4 due to HIF-1alpha accumulation that is caused by nickel in lung cells may be one mechanism by which nickel exposure contributes to lung cancer progression. Nickel 149-155 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-66 31953414-5 2020 We found that iPSC-derived iNeurons from a MAPT mutation carrier tend to be more sensitive to cell death induced by chromium (Cr) and nickel (Ni) exposure than an isogenic control line. Nickel 134-140 microtubule associated protein tau Homo sapiens 43-47 31580951-4 2020 Compared with most of state-of-the-art transition-metal-based catalysts, the Ni3S2/Ni/NF electrode displays extremely low overpotential and small Tafel slope (54 mV dec-1) as well as excellent stability. Nickel 77-82 deleted in esophageal cancer 1 Homo sapiens 165-170 31825209-4 2020 CoSe-0.2/NiSe-nrs/NF (Co/Ni molar ratio of 0.26) exhibits an excellent OER activity (overpotential of 310 mV at 100 mA cm-2 and tafel slope of 58.3 mV dec-1). Nickel 9-13 deleted in esophageal cancer 1 Homo sapiens 151-156 31799573-3 2020 The best oxygen evolution reaction (OER) performance was achieved by 25 h-Ni3S2-NF catalyst, which required merely 241 mV overpotential to deliver a current density of 20 mA cm-2, and its Tafel slope was as low as ~40 mV dec-1, which was superior to most nickel-based catalysts, in 1 M KOH electrolyte. Nickel 74-79 deleted in esophageal cancer 1 Homo sapiens 221-226 31807736-2 2020 Herein, a free-standing MnCo2S4@CoNi LDH (MCS@CN LDH) core-shell heterostructure is successfully prepared on Ni foam using the hydrothermal reaction and electrodeposition. Nickel 32-36 Miles-Carpenter X-linked mental retardation syndrome Homo sapiens 42-52 31829381-2 2020 The compositional and structural studies revealed that the cationic substitution of Cd2+ by Ni2+ ions leads to a monotonic shift in the (220) diffraction peak, indicating the suppression of lattice distortion, while the evolution of local strain with an increase in Ni concentration is mainly associated with the mismatch in the electronegativity of the Cd2+ and Ni2+ ions. Nickel 92-96 CD2 molecule Homo sapiens 84-87 31829381-2 2020 The compositional and structural studies revealed that the cationic substitution of Cd2+ by Ni2+ ions leads to a monotonic shift in the (220) diffraction peak, indicating the suppression of lattice distortion, while the evolution of local strain with an increase in Ni concentration is mainly associated with the mismatch in the electronegativity of the Cd2+ and Ni2+ ions. Nickel 92-96 CD2 molecule Homo sapiens 354-357 31829381-2 2020 The compositional and structural studies revealed that the cationic substitution of Cd2+ by Ni2+ ions leads to a monotonic shift in the (220) diffraction peak, indicating the suppression of lattice distortion, while the evolution of local strain with an increase in Ni concentration is mainly associated with the mismatch in the electronegativity of the Cd2+ and Ni2+ ions. Nickel 363-367 CD2 molecule Homo sapiens 84-87 31830156-4 2020 As such, we have performed density functional theory (DFT) calculations to study the two possible C-C cleavage pathways of n-butane on Ni(111), i.e., the (C-C)alpha,beta cleavage from the n-butane deep dehydrogenation product of 1-butyne, and the (C-C)beta,beta" cleavage from 2-butyne. Nickel 135-142 fibrillin 2 Homo sapiens 155-164 31789138-5 2020 Few reports claim an effect of Ni2+ at the level of GBA and serotonin neurotransmission. Nickel 31-35 glucosylceramidase beta Homo sapiens 52-55 31804169-3 2020 DISCUSSION: Nickel and oxidative stress: Nickel alters intracellular chemical microenvironment by increasing ionized calcium concentration, lipid peroxidation, cyclooxygenase, constitutive nitric oxide synthase, leukotriene B4, prostaglandin E2, interleukins, tumor necrosis factor-alpha, caspases, complement activation, heat shock protein 70 kDa and hypoxia-inducible factor-1alpha. Nickel 41-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 322-383 31804169-5 2020 It has been observed that nickel exposure induces the generation of reactive oxygen species which leads to the increased expression of p53, NF-kbeta, AP-1, and MAPK. Nickel 26-32 tumor protein p53 Homo sapiens 135-138 31734518-6 2020 Moreover, zinc mitigated nickel-mediated decrease in acetylcholinesterase activity, elevation in biomarkers of liver damage, levels of reactive oxygen and nitrogen species as well as lipid peroxidation in the exposed rats when compared with control. Nickel 25-31 acetylcholinesterase Rattus norvegicus 53-73 31734518-7 2020 Additionally, nickel mediated decrease in antioxidant enzyme activities as well as the increase in tumour necrosis factor alpha, interleukin-1 beta and caspase-3 activity were markedly abrogated in the cerebrum, cerebellum and liver of rats co-exposed to nickel and zinc. Nickel 14-20 interleukin 1 beta Rattus norvegicus 129-147 31734518-7 2020 Additionally, nickel mediated decrease in antioxidant enzyme activities as well as the increase in tumour necrosis factor alpha, interleukin-1 beta and caspase-3 activity were markedly abrogated in the cerebrum, cerebellum and liver of rats co-exposed to nickel and zinc. Nickel 14-20 caspase 3 Rattus norvegicus 152-161 31734518-9 2020 Taken together, zinc abrogated nickel-induced neurohepatic damage via suppression of oxido-inflammatory stress and caspase-3 activation in rats. Nickel 31-37 caspase 3 Rattus norvegicus 115-124 32884958-4 2020 The rCL1 was purified by nickel affinity chromatography with a HisTrap Column. Nickel 25-31 RNA terminal phosphate cyclase-like 1 Rattus norvegicus 4-8 32014793-6 2020 Gene mutation at the hprt locus was tested, with and without metabolic activation, after 4-h treatment with 0.05-2.5 mM nickel metal powder. Nickel 120-126 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 21-25 32129160-3 2020 The fusion protein, trx-hAS, was initially released by osmotic shock treatment from the host cells and subsequently purified using a nickel affinity chromatography. Nickel 133-139 thioredoxin Homo sapiens 20-23 32129160-3 2020 The fusion protein, trx-hAS, was initially released by osmotic shock treatment from the host cells and subsequently purified using a nickel affinity chromatography. Nickel 133-139 long intergenic non-protein coding RNA 2605 Homo sapiens 24-27 31606642-8 2019 At biochemical level, only G/Ni1 nanocomposite showed to interfere with the measured parameters, increasing the activities of ChE, CAT and GST. Nickel 29-32 catalase Danio rerio 131-134 31769769-2 2019 The results indicate that Pr2Ni2In and Nd2Ni2In compounds have a tetragonal Mo2FeB2-type structure belonging to the P4/mbm space group and undergo a second-order paramagnetic to ferromagnetic (PM to FM) transition at a Curie temperature (TC) of 7.5 and 10.5 K, respectively, whereas Dy2Ni2In and Ho2Ni2In compounds have an orthorhombic Mn2AlB2-type structure belonging to the space group Cmmm and possess a magnetic transition from PM to antiferromagnetic (AFM) at a Neel temperature TN of 19 and 10.5 K together with a first-order field induced metamagnetic transition, respectively. Nickel 26-34 solute carrier family 10 member 4 Homo sapiens 116-122 31782456-5 2019 In ethylene homopolymerization, the addition of Co(OTf)2 to our nickel-PEG complexes provided the largest boost in activity (up to 11-fold, 2.7 x 106 g mol-1 h-1) compared to that in the absence of external salts. Nickel 64-70 POU class 2 homeobox 2 Homo sapiens 48-56 31774259-1 2019 A highly transparent and flexible percolative composite with magnetic reduced graphene oxide@nickel nanowires (mGN) fillers in Ecoflex matrix is proposed as sensing layer to fabricate high performance flexible piezoresistive sensors. Nickel 93-99 helt bHLH transcription factor Mus musculus 111-114 31875162-5 2019 Recombinant His6-tagged S. mutans MurI was overexpressed in the expression vector pColdII and further purified using a Ni2+ affinity chromatography method. Nickel 119-123 glutamate racemase Streptococcus mutans UA159 34-38 31852525-0 2019 Nuclear factor erythroid 2 - related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis. Nickel 93-99 NFE2 like bZIP transcription factor 2 Homo sapiens 0-45 31852525-3 2019 Proposed mechanisms suggest that nickel and NCC may participate in the dual activation/inactivation of enzymatic pathways involved in cell defenses against oxidative damage, where Nuclear factor-erythroid 2 related factor 2 (Nrf2) plays a central role. Nickel 33-39 NFE2 like bZIP transcription factor 2 Homo sapiens 180-223 31852525-3 2019 Proposed mechanisms suggest that nickel and NCC may participate in the dual activation/inactivation of enzymatic pathways involved in cell defenses against oxidative damage, where Nuclear factor-erythroid 2 related factor 2 (Nrf2) plays a central role. Nickel 33-39 NFE2 like bZIP transcription factor 2 Homo sapiens 225-229 31852525-4 2019 METHODS: For assessing the potential role of proteins involved in the Nrf2-mediated response to nickel and NCC exposure, we designed an interactome network using the STITCH search engine version 5.0 and the STRING software 10.0. Nickel 96-102 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 31773953-0 2019 Photo- and Thermoswitchable Half-Sandwich Nickel(II) Complex: [Ni(eta5-C5H5)(IMes)(eta1-NO2)]. Nickel 42-52 secreted phosphoprotein 1 Homo sapiens 83-87 31773953-6 2019 3 h at 100 K approximately 20% conversion of the eta1-nitro (Ni-NO2) ligand to its exo-nitrito (Ni-ONO) form was observed. Nickel 61-67 secreted phosphoprotein 1 Homo sapiens 49-53 31773953-6 2019 3 h at 100 K approximately 20% conversion of the eta1-nitro (Ni-NO2) ligand to its exo-nitrito (Ni-ONO) form was observed. Nickel 96-102 secreted phosphoprotein 1 Homo sapiens 49-53 31803717-3 2019 It"s found that bracelet-like nanoplatelets were obtained at x = 0.4 and exhibit highest catalytic performance with turnover frequency of 33.43 molhydrogen min-1 mol cat - 1 , which much higher than those of most of CuNi-based catalysts in the literature. Nickel 219-223 CD59 molecule (CD59 blood group) Homo sapiens 156-161 31830904-7 2019 Lastly, based on these PC axes, cIMT was also regressed on summed (Sigma) organic compound concentrations, polychlorinated biphenyl, perfluorinated compounds, respectively, 10 OCs, 13 PCBs, 3PFCs, and nickel. Nickel 204-210 CIMT Homo sapiens 32-36 31830904-12 2019 Results show that that both nickel, and 3PFCs were similarly associated with cIMT beta = 0.001 (95 % CI 0.0003, 0.003), and beta = 0.001 (95 % CI 0.0004, 0.002), respectively. Nickel 28-34 CIMT Homo sapiens 78-82 31755485-3 2019 Here, using first-principles simulations, we demonstrate that the dual-defective SnS2 (Ni-SnS2-VS), by both single-atom nickel doping and sulfur monovacancies, becomes a promising two-dimensional photocatalyst compared with SnS2. Nickel 120-126 sodium voltage-gated channel alpha subunit 11 Homo sapiens 81-85 31755485-3 2019 Here, using first-principles simulations, we demonstrate that the dual-defective SnS2 (Ni-SnS2-VS), by both single-atom nickel doping and sulfur monovacancies, becomes a promising two-dimensional photocatalyst compared with SnS2. Nickel 120-126 sodium voltage-gated channel alpha subunit 11 Homo sapiens 87-97 31755485-3 2019 Here, using first-principles simulations, we demonstrate that the dual-defective SnS2 (Ni-SnS2-VS), by both single-atom nickel doping and sulfur monovacancies, becomes a promising two-dimensional photocatalyst compared with SnS2. Nickel 120-126 sodium voltage-gated channel alpha subunit 11 Homo sapiens 90-94 31822637-0 2019 Nickel induces inflammatory activation via NF-kappaB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 43-52 31822637-0 2019 Nickel induces inflammatory activation via NF-kappaB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Nickel 0-6 interferon regulatory factor 3 Homo sapiens 61-65 31822637-0 2019 Nickel induces inflammatory activation via NF-kappaB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Nickel 0-6 NLR family pyrin domain containing 3 Homo sapiens 70-75 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 nuclear factor kappa B subunit 1 Homo sapiens 43-65 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 nuclear factor kappa B subunit 1 Homo sapiens 67-76 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 interferon regulatory factor 3 Homo sapiens 125-155 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 interferon regulatory factor 3 Homo sapiens 157-161 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 interleukin 1 beta Homo sapiens 281-298 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 interleukin 1 beta Homo sapiens 300-308 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 tumor necrosis factor Homo sapiens 324-351 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 tumor necrosis factor Homo sapiens 353-362 31822637-3 2019 Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta). Nickel 27-32 interferon beta 1 Homo sapiens 368-383 31822637-4 2019 We also found that nickel chloride (NiCl2) activated Nod-like receptor 3 (NLRP3) inflammasome pathway, resulting in the proteolytic cleavage and release of IL-1beta. Nickel 36-41 NLR family pyrin domain containing 3 Homo sapiens 53-72 31822637-4 2019 We also found that nickel chloride (NiCl2) activated Nod-like receptor 3 (NLRP3) inflammasome pathway, resulting in the proteolytic cleavage and release of IL-1beta. Nickel 36-41 NLR family pyrin domain containing 3 Homo sapiens 74-79 31822637-4 2019 We also found that nickel chloride (NiCl2) activated Nod-like receptor 3 (NLRP3) inflammasome pathway, resulting in the proteolytic cleavage and release of IL-1beta. Nickel 36-41 interleukin 1 beta Homo sapiens 156-164 31822637-5 2019 NiCl2 induced the accumulation of mitochondrial reactive oxygen species (mtROS) and the release of mitochondrial DNA (mtDNA), thus activating NLRP3 inflammasome pathway. Nickel 0-5 NLR family pyrin domain containing 3 Homo sapiens 142-147 31822637-7 2019 Altogether, abovementioned results indicate that NiCl2 induces inflammatory activation in BMDMs via NF-kappaB, MAPKs, IRF3 signaling pathways as well as NLRP3 inflammasome pathway, which provides a mechanism to improve the efficiency of treatment against Ni-induced allergic reactions. Nickel 49-54 nuclear factor kappa B subunit 1 Homo sapiens 100-109 31822637-7 2019 Altogether, abovementioned results indicate that NiCl2 induces inflammatory activation in BMDMs via NF-kappaB, MAPKs, IRF3 signaling pathways as well as NLRP3 inflammasome pathway, which provides a mechanism to improve the efficiency of treatment against Ni-induced allergic reactions. Nickel 49-54 interferon regulatory factor 3 Homo sapiens 118-122 31822637-7 2019 Altogether, abovementioned results indicate that NiCl2 induces inflammatory activation in BMDMs via NF-kappaB, MAPKs, IRF3 signaling pathways as well as NLRP3 inflammasome pathway, which provides a mechanism to improve the efficiency of treatment against Ni-induced allergic reactions. Nickel 49-54 NLR family pyrin domain containing 3 Homo sapiens 153-158 31674149-1 2019 Coordination complexes of an olefinic molecule (PIP) containing pyridine and imidazopyridine moieties with Zn(II)/Ni(II) metal salts were shown to exhibit appreciable proton conductivity. Nickel 114-120 prolactin induced protein Homo sapiens 48-51 31816999-5 2019 We found that hDMP1 was transiently expressed in N. benthamiana leaves and could be purified by ammonium sulphate precipitation followed by nickel affinity chromatography. Nickel 140-146 dentin matrix acidic phosphoprotein 1 Homo sapiens 14-19 31710221-6 2019 Cyclic voltammetry revealed a reversible oxidation to the monocation [NiCp(L)]+ (E1/2 = 0.315, 0.222, 0.396, 0.265 V vs ferrocene/ferrocenium for L = 1"Me, 1"iPr, 2"Me, 2"iPr, respectively) in CH2Cl2/0.1 M n-Bu4N[B(ArF)4] (B(ArF)4- = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), and isosbestic behavior was found in UV-vis-NIR spectroelectrochemical experiments. Nickel 69-79 ADP ribosylation factor 4 Homo sapiens 215-230 31710221-8 2019 The EPR spectroscopic signature of [NiCp(2"Me)]+ in CH2Cl2/0.1 M n-Bu4N[B(ArF)4] at 100 K is consistent with a chelate-ligand-based radical with strong spin-orbit coupling to the Ni center. Nickel 35-48 ADP ribosylation factor 4 Homo sapiens 74-79 31398612-8 2019 Further, zinc abrogated nickel-mediated elevation in inflammatory biomarkers including nitric oxide, tumor necrosis factor alpha, interleukin-1 beta as well as caspase-3 activity. Nickel 24-30 tumor necrosis factor Rattus norvegicus 101-128 31398612-8 2019 Further, zinc abrogated nickel-mediated elevation in inflammatory biomarkers including nitric oxide, tumor necrosis factor alpha, interleukin-1 beta as well as caspase-3 activity. Nickel 24-30 interleukin 1 beta Rattus norvegicus 130-148 31398612-8 2019 Further, zinc abrogated nickel-mediated elevation in inflammatory biomarkers including nitric oxide, tumor necrosis factor alpha, interleukin-1 beta as well as caspase-3 activity. Nickel 24-30 caspase 3 Rattus norvegicus 160-169 31066035-8 2019 In conclusion, NiCl2 induces the expression of ITGB3 through TGF-beta signaling activation, followed by increasing VEGF-a secretion, revealing a novel role for ITGB3 in nickel compound-induced cancer metastasis and tumor angiogenesis. Nickel 169-175 integrin subunit beta 3 Homo sapiens 160-165 31505333-4 2019 The stepwise electrodeposited nickel-iron hydroxide (NiFe(OH)2-SD/NF) electrodes show excellent electrocatalytic activity and stability for the oxygen evolution reaction (OER) with a low potential of 1.45 V (vs RHE) at a current density of 10 mA cm-2. Nickel 30-36 factor interacting with PAPOLA and CPSF1 Homo sapiens 211-214 31660548-4 2019 In this study, planar mononuclear Ni(L1)2 (L1 = 2-ethoxy-6-(iminomethyl)phenol) was dissolved in methanol and combined with Dy(NO3)3 6H2O for 48 h at room temperature to obtain a butterfly-like Ni2Dy2 cluster ([Dy2Ni2(L1)4(CH3O)2(NO3)4], 1). Nickel 194-200 LINE1 retrotransposable element 1 Homo sapiens 34-41 31660548-7 2019 Six key intermediate fragments were screened, and the self-assembly mechanism was proposed as Ni(L1)2 HL1 + NiL1 DyL1/Ni(L1)2" DyNi(L1)2 Dy2Ni2(L1)4. Nickel 133-156 LINE1 retrotransposable element 1 Homo sapiens 94-101 31660548-7 2019 Six key intermediate fragments were screened, and the self-assembly mechanism was proposed as Ni(L1)2 HL1 + NiL1 DyL1/Ni(L1)2" DyNi(L1)2 Dy2Ni2(L1)4. Nickel 133-156 intelectin 1 Homo sapiens 104-107 31660548-7 2019 Six key intermediate fragments were screened, and the self-assembly mechanism was proposed as Ni(L1)2 HL1 + NiL1 DyL1/Ni(L1)2" DyNi(L1)2 Dy2Ni2(L1)4. Nickel 133-156 LINE1 retrotransposable element 1 Homo sapiens 122-129 31660548-8 2019 Through this assembly mechanism, we found that Ni(L1)2 was first cleaved into HL1 + NiL1 and then further assembled to obtain 1. Nickel 84-88 LINE1 retrotransposable element 1 Homo sapiens 47-54 31660548-8 2019 Through this assembly mechanism, we found that Ni(L1)2 was first cleaved into HL1 + NiL1 and then further assembled to obtain 1. Nickel 84-88 intelectin 1 Homo sapiens 78-81 32626193-7 2019 Due to the presence of nickel, CI-FER should also be considered as a dermal and respiratory sensitiser. Nickel 23-29 FER tyrosine kinase Homo sapiens 34-37 31667482-4 2019 During this process, we converted a Co-MOF to a CoNi-MOF by ion exchange and low-temperature phosphating to achieve CoNiP nanoboxes. Nickel 116-121 lysine acetyltransferase 8 Homo sapiens 39-42 31667482-4 2019 During this process, we converted a Co-MOF to a CoNi-MOF by ion exchange and low-temperature phosphating to achieve CoNiP nanoboxes. Nickel 116-121 lysine acetyltransferase 8 Homo sapiens 53-56 31667482-5 2019 The CoNiP nanoboxes can reach a current density of 10 mA cm-2 at a low overpotential of 138 mV with a small Tafel slope of 65 mV dec-1. Nickel 4-9 deleted in esophageal cancer 1 Homo sapiens 129-134 31746907-4 2019 Benefiting from the large exposed surface area and fast charge transfer, the obtained ultrathin NiOx/Ni heterostructured nanosheets exhibit an overpotential of 358 mV at a current density of 10 mA cm-2 and a small Tafel slope of 51 mV dec-1, outperforming other reported representative nickel oxide based materials and commercial Ir/C catalysts. Nickel 96-100 deleted in esophageal cancer 1 Homo sapiens 235-240 31769895-4 2020 Owing to the presence of sulfide interfaces, the PtNiCo/NiCoS IFNWs enable an impressive methanol/ethanol oxidation reaction (MOR/EOR) performance and excellent anti-CO poisoning tolerance. Nickel 49-55 opioid receptor mu 1 Homo sapiens 126-129 31769895-4 2020 Owing to the presence of sulfide interfaces, the PtNiCo/NiCoS IFNWs enable an impressive methanol/ethanol oxidation reaction (MOR/EOR) performance and excellent anti-CO poisoning tolerance. Nickel 56-61 opioid receptor mu 1 Homo sapiens 126-129 31766599-0 2019 Improving the Light-Induced Spin Transition Efficiency in Ni(II)-Based Macrocyclic-Ligand Complexes. Nickel 58-64 spindlin 1 Homo sapiens 28-32 31608640-5 2019 Investigation of the photochemical behavior under catalytic conditions in conjunction with thermochemical analyses suggests that ET to the catalytic nickel site from the reductively quenched ruthenium center is the rate-determining step. Nickel 149-155 major facilitator superfamily domain containing 11 Homo sapiens 129-131 31815226-4 2019 NF@Ni3S2@NCNTs exhibit an overpotential of 93.89 mV at a current density of 10 mA cm-2, a Tafel slope of 54 mV dec-1, and superior stability for HER in 1 M KOH solution. Nickel 3-8 deleted in esophageal cancer 1 Homo sapiens 111-116 31682428-5 2019 The scan rate dependence revealed evidence for an ECE mechanism in which the chemical step constituted ligand exchange between [NiIII(dtc)2]+ and NiII(dtc)2. Nickel 127-141 endothelin converting enzyme 1 Homo sapiens 50-53 31682428-5 2019 The scan rate dependence revealed evidence for an ECE mechanism in which the chemical step constituted ligand exchange between [NiIII(dtc)2]+ and NiII(dtc)2. Nickel 128-132 endothelin converting enzyme 1 Homo sapiens 50-53 31606392-0 2019 Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells. Nickel 0-6 NLR family pyrin domain containing 3 Homo sapiens 29-34 31803717-3 2019 It"s found that bracelet-like nanoplatelets were obtained at x = 0.4 and exhibit highest catalytic performance with turnover frequency of 33.43 molhydrogen min-1 mol cat - 1 , which much higher than those of most of CuNi-based catalysts in the literature. Nickel 219-223 GIT ArfGAP 1 Homo sapiens 167-174 31657897-4 2019 Besides, the produced CoP/NiCoP heterostructure in the bimetallic Ni-Co-P catalyst has excellent HER performance in a wide pH range. Nickel 26-31 caspase recruitment domain family member 16 Homo sapiens 22-25 31657897-4 2019 Besides, the produced CoP/NiCoP heterostructure in the bimetallic Ni-Co-P catalyst has excellent HER performance in a wide pH range. Nickel 66-73 caspase recruitment domain family member 16 Homo sapiens 22-25 31719180-0 2019 Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling. Nickel 55-59 2-5A-dependent ribonuclease Rousettus aegyptiacus 14-21 31719180-6 2019 Analysis of the Egyptian Rousette bat genome combined with mRNA sequencing from bat RoNi/7 cells revealed three homologous OAS proteins. Nickel 84-88 SPARC related modular calcium binding 1 Homo sapiens 123-126 31719180-11 2019 Thus, in RoNi/7 bat cells, as in human cells, activation of RNase L during infection and its antiviral activity are dependent primarily on OAS3 while MAVS signaling is not required for the activation of RNase L and restriction of infection. Nickel 9-13 ribonuclease L Homo sapiens 60-67 31719180-11 2019 Thus, in RoNi/7 bat cells, as in human cells, activation of RNase L during infection and its antiviral activity are dependent primarily on OAS3 while MAVS signaling is not required for the activation of RNase L and restriction of infection. Nickel 9-13 2'-5'-oligoadenylate synthetase 3 Homo sapiens 139-143 31486254-0 2019 Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates. Nickel 118-124 cytochrome c, somatic Homo sapiens 35-47 31486254-2 2019 Herein, we investigate the structural changes of CL-bound Fe2+ Cyt c and the correlation with Cyt c release through surface-enhanced Raman spectroscopy (SERS) on nickel substrates. Nickel 162-168 cytochrome c, somatic Homo sapiens 94-99 31591877-2 2019 Herein, binder-free cobalt molybdate nanosheets laminated cobalt phosphate micropetals on nickel foam (CoM NSs@CoP/NF) were facilely prepared for use as an effective battery-type electrode in hybrid SCs. Nickel 90-96 caspase recruitment domain family member 16 Homo sapiens 111-114 31603301-3 2019 The optimal Ni-BDC@NiS catalyst acquires a current density of 20 mA cm-2 at a lower overpotential of 330 mV and low Tafel slope of 62 mV dec-1, outperforming previous reported most of Ni-based sulfides catalysts. Nickel 12-18 deleted in esophageal cancer 1 Homo sapiens 137-142 31638777-1 2019 RuNi nanoparticles supported on a metal-organic framework (RuNi@MOF) and formed in situ from a ruthenium complex enclosed inside a nickel-based MOF act as a highly active catalyst for the Guerbet reaction of ethanol to 1-butanol, providing turnover numbers up to 725 000 Ru-1. Nickel 131-137 lysine acetyltransferase 8 Homo sapiens 64-67 31638777-1 2019 RuNi nanoparticles supported on a metal-organic framework (RuNi@MOF) and formed in situ from a ruthenium complex enclosed inside a nickel-based MOF act as a highly active catalyst for the Guerbet reaction of ethanol to 1-butanol, providing turnover numbers up to 725 000 Ru-1. Nickel 131-137 lysine acetyltransferase 8 Homo sapiens 144-147 33654909-3 2019 We used nickel beads to isolate His-tagged KIN-19 and RHO-1, and thus permitting the isolation of both small and large aggregated or fibrillary forms of the proteins. Nickel 8-14 Casein kinase I isoform alpha Caenorhabditis elegans 43-49 33654909-3 2019 We used nickel beads to isolate His-tagged KIN-19 and RHO-1, and thus permitting the isolation of both small and large aggregated or fibrillary forms of the proteins. Nickel 8-14 Ras-like GTP-binding protein rhoA Caenorhabditis elegans 54-59 31912043-0 2019 Dual-Color Lasing Lines from EMPs in Diluted Magnetic Semiconductor CdS:NiI Structure. Nickel 72-75 CDP-diacylglycerol synthase 1 Homo sapiens 68-71 31912043-3 2019 Here, we have observed dual lasing lines of 530 nm and 789 nm from a DMS structure of CdS:NiI, in which the excitonic magnetic polaron (EMP) and localized excitonic magnetic polaron (LEMP) are excitations out of ferromagnetic (NiS) x nanocluster and NiI2 nanoclusters within CdS lattice; both of them could lead to the collective EMP state at high excitation and therein produce coherent emission lines simultaneously. Nickel 90-93 CDP-diacylglycerol synthase 1 Homo sapiens 86-89 31912043-3 2019 Here, we have observed dual lasing lines of 530 nm and 789 nm from a DMS structure of CdS:NiI, in which the excitonic magnetic polaron (EMP) and localized excitonic magnetic polaron (LEMP) are excitations out of ferromagnetic (NiS) x nanocluster and NiI2 nanoclusters within CdS lattice; both of them could lead to the collective EMP state at high excitation and therein produce coherent emission lines simultaneously. Nickel 227-230 CDP-diacylglycerol synthase 1 Homo sapiens 86-89 31912043-3 2019 Here, we have observed dual lasing lines of 530 nm and 789 nm from a DMS structure of CdS:NiI, in which the excitonic magnetic polaron (EMP) and localized excitonic magnetic polaron (LEMP) are excitations out of ferromagnetic (NiS) x nanocluster and NiI2 nanoclusters within CdS lattice; both of them could lead to the collective EMP state at high excitation and therein produce coherent emission lines simultaneously. Nickel 250-254 CDP-diacylglycerol synthase 1 Homo sapiens 86-89 31912043-4 2019 This occurrence is due to the superposition of EMP near CdS bandedge and the combination of the charge-transfer band of (NiI) n cluster with the LEMP within CdS lattice by overcoming the strong electron correlation of NiI cluster in a DMS structure, evidenced also by ab initio calculation. Nickel 121-124 CDP-diacylglycerol synthase 1 Homo sapiens 157-160 31912043-4 2019 This occurrence is due to the superposition of EMP near CdS bandedge and the combination of the charge-transfer band of (NiI) n cluster with the LEMP within CdS lattice by overcoming the strong electron correlation of NiI cluster in a DMS structure, evidenced also by ab initio calculation. Nickel 218-221 CDP-diacylglycerol synthase 1 Homo sapiens 157-160 31682627-4 2019 Hypoxia-mimicking conditions, which include NiCl2, CoCl2, and DMOG, an inhibitor of 2-oxoglutarate-dependent enzymes, also selectively inhibited TNF-alpha-induced TSLP expression. Nickel 44-49 tumor necrosis factor Homo sapiens 145-154 31682627-4 2019 Hypoxia-mimicking conditions, which include NiCl2, CoCl2, and DMOG, an inhibitor of 2-oxoglutarate-dependent enzymes, also selectively inhibited TNF-alpha-induced TSLP expression. Nickel 44-49 thymic stromal lymphopoietin Homo sapiens 163-167 31087782-2 2019 Herein, a novel nanoflower-like electrocatalyst comprising few-layer nitrogen-doped graphene-encapsulated nickel-copper alloy directly on a porous nitrogen-doped graphic carbon framework (denoted as Nix Cuy @ NG-NC) is successfully synthesized using a facile and scalable method through calcinating the carbon, copper, and nickel hydroxy carbonate composite under inert atmosphere. Nickel 106-112 BCL2 interacting protein 3 like Homo sapiens 199-202 31649341-9 2019 The experimental results were supported by Density Functional Theory (DFT) studies, which revealed that the lowest CO poisoning of the Pt1Ni1 catalyst among all Ptm-Nin mixing ratios may account for the enhanced methanol oxidation. Nickel 135-141 ninein Homo sapiens 165-168 31455607-7 2019 Further, role of three differentially expressed genes i.e. MAN1B1, MAN1A1 and MAN2A1 in regulation of NIS localization is confirmed by RNA interference. Nickel 102-105 mannosidase alpha class 1B member 1 Homo sapiens 59-65 31739418-2 2019 The first one involves an aluminum containing MOF precursor used as sacrificial template to deposit nickel while the second is based on a one-pot synthesis combined to an EISA method. Nickel 100-106 lysine acetyltransferase 8 Homo sapiens 46-49 31709090-3 2019 Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature. Nickel 187-216 mitochondrially encoded cytochrome c oxidase II Homo sapiens 269-273 31709090-3 2019 Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature. Nickel 275-279 mitochondrially encoded cytochrome c oxidase II Homo sapiens 269-273 31273981-0 2019 Bimodal Nickel-Binding Site on Escherichia coli [NiFe]-Hydrogenase Metallochaperone HypA. Nickel 8-14 hypA Escherichia coli 84-88 31273981-3 2019 The penultimate maturation step is the delivery of nickel to a primed hydrogenase enzyme precursor protein, a process that is accomplished by two nickel metallochaperones, the accessory protein HypA and the GTPase HypB. Nickel 51-57 hypA Escherichia coli 194-198 31273981-3 2019 The penultimate maturation step is the delivery of nickel to a primed hydrogenase enzyme precursor protein, a process that is accomplished by two nickel metallochaperones, the accessory protein HypA and the GTPase HypB. Nickel 146-152 hypA Escherichia coli 194-198 31273981-4 2019 Recent work demonstrated that nickel is rapidly transferred to HypA from GDP-loaded HypB within the context of a protein complex in a nickel selective and unidirectional process. Nickel 30-36 hypA Escherichia coli 63-67 31273981-4 2019 Recent work demonstrated that nickel is rapidly transferred to HypA from GDP-loaded HypB within the context of a protein complex in a nickel selective and unidirectional process. Nickel 134-140 hypA Escherichia coli 63-67 31273981-5 2019 To investigate the mechanism of metal transfer, we examined the allosteric effects of nucleotide cofactors and partner proteins on the nickel environments of HypA and HypB by using a combination of biochemical, microbiological, computational, and spectroscopic techniques. Nickel 135-141 hypA Escherichia coli 158-162 31273981-7 2019 In addition, interaction with a mutant version of HypA with disrupted nickel binding, H2Q-HypA, does not induce substantial changes to the HypB G-domain nickel site. Nickel 70-76 hypA Escherichia coli 50-54 31273981-7 2019 In addition, interaction with a mutant version of HypA with disrupted nickel binding, H2Q-HypA, does not induce substantial changes to the HypB G-domain nickel site. Nickel 70-76 hypA Escherichia coli 90-94 31273981-9 2019 Analysis of a peptide maquette derived from the N-terminus of HypA revealed that nickel is predominately coordinated by atoms from the N-terminal Met-His motif. Nickel 81-87 hypA Escherichia coli 62-66 31273981-10 2019 Furthermore, HypA is capable of two nickel-binding modes at the N-terminus, a HypB-induced mode and a binding mode that mirrors the peptide maquette. Nickel 36-42 hypA Escherichia coli 13-17 31273981-11 2019 Collectively, these results reveal that HypB brings about changes in the nickel coordination of HypA, providing a mechanism for the HypB-dependent control of the acquisition and release of nickel by HypA. Nickel 73-79 hypA Escherichia coli 96-100 31273981-11 2019 Collectively, these results reveal that HypB brings about changes in the nickel coordination of HypA, providing a mechanism for the HypB-dependent control of the acquisition and release of nickel by HypA. Nickel 73-79 hypA Escherichia coli 199-203 31273981-11 2019 Collectively, these results reveal that HypB brings about changes in the nickel coordination of HypA, providing a mechanism for the HypB-dependent control of the acquisition and release of nickel by HypA. Nickel 189-195 hypA Escherichia coli 96-100 31273981-11 2019 Collectively, these results reveal that HypB brings about changes in the nickel coordination of HypA, providing a mechanism for the HypB-dependent control of the acquisition and release of nickel by HypA. Nickel 189-195 hypA Escherichia coli 199-203 31247878-1 2019 E. coli RcnR (resistance to cobalt and nickel regulator) is a homotetrameric DNA binding protein that regulates the expression of a Ni(II) and Co(II) exporter (RcnAB) by derepressing expression of rcnA and rcnB in response to binding Co(II) or Ni(II). Nickel 39-45 DNA-binding protein Escherichia coli 77-96 31549802-4 2019 As the calcination temperature increases from 300 to 500 C, the crystal pattern transformed from CoP with nickel ions uniformly intercalating into the lattice to the CoNiP structure. Nickel 107-113 caspase recruitment domain family member 16 Homo sapiens 98-101 31549802-4 2019 As the calcination temperature increases from 300 to 500 C, the crystal pattern transformed from CoP with nickel ions uniformly intercalating into the lattice to the CoNiP structure. Nickel 167-172 caspase recruitment domain family member 16 Homo sapiens 98-101 31576866-1 2019 The reaction of the phosphine functionalized chlorogermylene 1 with Ni(COD)2 (COD = 1,5-cyclooctadiene) afforded the bis-chlorogermylene ligated nickel(0) complex 2 in high yield. Nickel 145-154 COD2 Homo sapiens 71-76 31576866-1 2019 The reaction of the phosphine functionalized chlorogermylene 1 with Ni(COD)2 (COD = 1,5-cyclooctadiene) afforded the bis-chlorogermylene ligated nickel(0) complex 2 in high yield. Nickel 145-154 retinitis pigmentosa GTPase regulator Homo sapiens 78-85 31581740-3 2019 One of the most studied metallochaperones is the nickel-binding protein HypA, involved in the maturation of nickel-dependent hydrogenases and ureases. Nickel 49-55 hypA Escherichia coli 72-76 31581740-3 2019 One of the most studied metallochaperones is the nickel-binding protein HypA, involved in the maturation of nickel-dependent hydrogenases and ureases. Nickel 108-114 hypA Escherichia coli 72-76 31325186-0 2019 Interleukin-1 and histamine are essential for inducing nickel allergy in mice. Nickel 55-61 interleukin 1 complex Mus musculus 0-13 31198997-3 2019 OBJECTIVES: To investigate whether this limitation of RhE might be attributable to a lack of functional expression of Toll-like receptor 4 (TLR4), which governs proinflammatory sensitivity to nickel and cobalt. Nickel 192-198 toll like receptor 4 Homo sapiens 140-144 31198997-6 2019 Unlike keratinocytes, normal human fibroblasts expressed high levels of TLR4 mRNA and induced interleukin-8 expression upon stimulation with nickel or cobalt. Nickel 141-147 C-X-C motif chemokine ligand 8 Homo sapiens 94-107 31066938-10 2019 Lower levels of nickel and manganese were associated with a statistically significant higher risk of a KRAS mutated PDAC (OR for manganese = 0.34, 95% CI 0.14-0.80). Nickel 16-22 KRAS proto-oncogene, GTPase Homo sapiens 103-107 31208618-8 2019 In H2SO4 solution, the nickel coating fabricated by US-SC-CO2 method displayed the best polarization resistance among the three processes. Nickel 23-29 complement C2 Homo sapiens 52-61 31234101-0 2019 Depth-profiling of nickel nanocrystal populations in a borosilicate glass - A combined TEM and XRM study. Nickel 19-25 MFT2 Homo sapiens 87-90 31455607-7 2019 Further, role of three differentially expressed genes i.e. MAN1B1, MAN1A1 and MAN2A1 in regulation of NIS localization is confirmed by RNA interference. Nickel 102-105 mannosidase alpha class 1A member 1 Homo sapiens 67-73 31455607-7 2019 Further, role of three differentially expressed genes i.e. MAN1B1, MAN1A1 and MAN2A1 in regulation of NIS localization is confirmed by RNA interference. Nickel 102-105 mannosidase alpha class 2A member 1 Homo sapiens 78-84 31569803-1 2019 The manufacture of highly complex components from nickel-based superalloys with laser powder bed fusion (L-PBF) technology can reduce the production costs parts with comparable microstructural and mechanical properties when compared to casting. Nickel 50-56 PTTG1 interacting protein Homo sapiens 107-110 31533238-7 2019 The sodium iodide symporter (NIS) is a plasma membrane glycoprotein, a member of solute carrier family 5A (SLC5A5), located on the basolateral surfaces of the thyroid follicular epithelial cells, which mediates active iodide transport into thyroid follicular cells. Nickel 29-32 solute carrier family 5 member 5 Homo sapiens 107-113 31533238-9 2019 In a study of patients with recurrent thyroid cancer, expression levels of specific ribosomal machinery-namely PIGU (phosphatidylinositol glycan anchor biosynthesis class U), a subunit of the GPI (glycosylphosphatidylinositol transamidase complex-correlated with RAI avidity in radioiodine scanning, NIS levels, and biochemical response to RAI treatment. Nickel 300-303 phosphatidylinositol glycan anchor biosynthesis class U Homo sapiens 111-115 31533238-9 2019 In a study of patients with recurrent thyroid cancer, expression levels of specific ribosomal machinery-namely PIGU (phosphatidylinositol glycan anchor biosynthesis class U), a subunit of the GPI (glycosylphosphatidylinositol transamidase complex-correlated with RAI avidity in radioiodine scanning, NIS levels, and biochemical response to RAI treatment. Nickel 300-303 glucose-6-phosphate isomerase Homo sapiens 192-195 31215682-2 2019 The nickel and palladium complexes, [NiL2 ], [PdL2 ] form square planar complexes with 2:1 ligand to metal ratio. Nickel 4-10 programmed cell death 1 ligand 2 Homo sapiens 46-50 31310439-1 2019 Hexagonal nickel-organic framework (Ni-MOF) [Ni(NO3 )2 6H2 O, 1,3,5-benzenetricarboxylic acid, 4-4"-bipyridine] is fabricated through a one-step solvothermal method. Nickel 10-16 lysine acetyltransferase 8 Homo sapiens 39-42 31331356-12 2019 RESULTS: HMGB1 was a critical regulator of autophagy-mediated NIS degradation in HBSS-treated FTC-133/TPC-1 cells. Nickel 62-65 high mobility group box 1 Homo sapiens 9-14 31420568-1 2019 A beta-zeolite-supported nickel and tungsten catalyst (Ni-W/beta) was employed to generate C2/C3 glycols (ethylene and propylene glycols) in a satisfactory yield from cellulose. Nickel 25-31 complement C2 Homo sapiens 91-104 31420568-4 2019 The characterization and reaction results indicated that the cellulose hydrolysis step was promoted by the appropriate acidic sites of the beta-zeolite, and the reaction routes to C2/C3 glycols were influenced by the mass loading of Ni-W through the synergy of nickel and tungsten oxide, in which Ni is effective in the hydrogenation while W facilitates bond cleavage via a retro-aldol condensation (C6 to C2/C3). Nickel 261-267 complement C2 Homo sapiens 180-193 31331356-14 2019 HMGB1-knockdown dramatically suppressed autophagy, NIS degradation and boosted iodide uptake in HBSS-treated cells. Nickel 51-54 high mobility group box 1 Homo sapiens 0-5 31331356-16 2019 A knockdown of HMGB1 suppressed LC3-II conversion and NIS degradation via an AMPK/mTOR-dependent signal pathway through a regulation of ROS generation, rather than ATP. Nickel 54-57 high mobility group box 1 Homo sapiens 15-20 31331356-18 2019 CONCLUSIONS: Acting as a critical regulator of autophagy-mediated NIS degradation via ROS/AMPK/mTOR pathway, HMGB1is a potential intervention target of radioiodine therapy in thyroid cancer. Nickel 66-69 high mobility group box 1 Homo sapiens 109-114 31245805-0 2019 NIS-mediated oxidative arene C(sp2)-H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives. Nickel 0-3 Sp2 transcription factor Homo sapiens 29-34 31300717-1 2019 A facile approach of chemical bath deposition was proposed to fabricate direct synthesis of silver sulphide (Ag2S) on nickel (Ni) mesh without involvement for binders for supercapacitor electrodes. Nickel 118-124 angiotensin II receptor type 1 Homo sapiens 109-113 31341700-5 2019 Spectroscopic and computational studies indicated that the NBP bound nickel in a distorted square planar geometry that validated the design. Nickel 69-75 NUBP iron-sulfur cluster assembly factor 1, cytosolic Homo sapiens 59-62 31247793-1 2019 A nickel-catalyzed coupling of N-sulfonyl-1,2,3-triazole with various H-phosphine oxides for the construction of C(sp2)-P bonds is established. Nickel 2-8 Sp2 transcription factor Homo sapiens 113-118 31252455-3 2019 Herein, we report a heterogeneous nanostructure of a Ni-based MOF-modified Ni3S2/NiS hollow nanoparticle. Nickel 81-84 lysine acetyltransferase 8 Homo sapiens 62-65 30465171-4 2019 Our study revealed that nickel could inhibit NSCs proliferation and differentiation, which is induced not only by the intracellular reactive oxygen species generation, but also by the protein levels upregulation of p-c-Raf, p-MEK1/2 and p-Erk1/2 through the axon guidance signal pathways. Nickel 24-30 v-raf-leukemia viral oncogene 1 Mus musculus 217-222 30465171-4 2019 Our study revealed that nickel could inhibit NSCs proliferation and differentiation, which is induced not only by the intracellular reactive oxygen species generation, but also by the protein levels upregulation of p-c-Raf, p-MEK1/2 and p-Erk1/2 through the axon guidance signal pathways. Nickel 24-30 mitogen-activated protein kinase kinase 1 Mus musculus 226-232 30465171-4 2019 Our study revealed that nickel could inhibit NSCs proliferation and differentiation, which is induced not only by the intracellular reactive oxygen species generation, but also by the protein levels upregulation of p-c-Raf, p-MEK1/2 and p-Erk1/2 through the axon guidance signal pathways. Nickel 24-30 mitogen-activated protein kinase 3 Mus musculus 239-245 30779159-6 2019 RESULTS: Patch test positivity for nickel, PPD and MI was associated with changes in the phenotype of peripheral blood T cells: increases in naive cells, decreases in regulatory T cell frequency and the CD4+ /CD8hi ratio, and increased expression of the skin-homing marker cutaneous lymphocyte antigen (CLA), particularly for those patients with a +++ patch test score. Nickel 35-41 CD4 molecule Homo sapiens 203-206 30779159-6 2019 RESULTS: Patch test positivity for nickel, PPD and MI was associated with changes in the phenotype of peripheral blood T cells: increases in naive cells, decreases in regulatory T cell frequency and the CD4+ /CD8hi ratio, and increased expression of the skin-homing marker cutaneous lymphocyte antigen (CLA), particularly for those patients with a +++ patch test score. Nickel 35-41 selectin P ligand Homo sapiens 303-306 31353727-3 2019 flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. Nickel 164-170 vascular endothelial growth factor A Homo sapiens 136-140 30765007-0 2019 Effects of Bath Composition and P Contents on the Defects of NiP Layer in Electroless Nickel Immersion Gold Process. Nickel 86-92 CDP-L-ribitol pyrophosphorylase A Homo sapiens 61-64 30765007-1 2019 Electroless nickel immersion gold (ENIG) has been widely used for surface finishing in PCB industry, however surface defects are sometimes found during PCB soldering process. Nickel 12-18 pyruvate carboxylase Homo sapiens 87-90 30963643-4 2019 The results of spectroscopic studies suggested that the oxidized nickel complex adopts a monomeric structure ([Ni](PF6 )) in CH2 Cl2 , but a dimeric structure ({[Ni](PF6 )}2 ) in the other investigated solvents. Nickel 65-71 sperm associated antigen 17 Homo sapiens 166-169 31115584-8 2019 The plasmid and scFv-RBP4 fusion protein were purified by nickel-iminodiacetic acid affinity chromatography. Nickel 58-64 immunglobulin heavy chain variable region Homo sapiens 16-20 31115584-8 2019 The plasmid and scFv-RBP4 fusion protein were purified by nickel-iminodiacetic acid affinity chromatography. Nickel 58-64 retinol binding protein 4 Homo sapiens 21-25 30744841-5 2019 Under optimized conditions, detection limit of 1.7 mug L-1 and 2.4 mug L-1, quantification limit of 5.6 mug L-1 and 7.9 mug L-1 and enrichment factors of 65 and 48 were obtained for nickel and cobalt, respectively. Nickel 182-188 immunoglobulin kappa variable 1-16 Homo sapiens 71-74 30744841-5 2019 Under optimized conditions, detection limit of 1.7 mug L-1 and 2.4 mug L-1, quantification limit of 5.6 mug L-1 and 7.9 mug L-1 and enrichment factors of 65 and 48 were obtained for nickel and cobalt, respectively. Nickel 182-188 immunoglobulin kappa variable 1-16 Homo sapiens 71-74 30744841-5 2019 Under optimized conditions, detection limit of 1.7 mug L-1 and 2.4 mug L-1, quantification limit of 5.6 mug L-1 and 7.9 mug L-1 and enrichment factors of 65 and 48 were obtained for nickel and cobalt, respectively. Nickel 182-188 immunoglobulin kappa variable 1-16 Homo sapiens 71-74 30744841-6 2019 Relative standard deviation (n = 7) for 100 mug L-1 nickel and cobalt were 3.6% and 3.8%, respectively. Nickel 52-58 immunoglobulin kappa variable 1-16 Homo sapiens 48-51 31261797-1 2019 Poly(norbornene-co-styrene)s were synthesized by the use of anilinonaphthoquinone-ligated nickel complexes [Ni(C10H5O2NAr)(Ph)(PPh3): 1a, Ar = C6H3-2,6-iPr; 1b, Ar = C6H2-2,4,6-Me; 1c, Ar = C6H5] activated with modified methylaluminoxane (MMAO) or B(C6F5)3 in toluene. Nickel 90-96 protein phosphatase 4 catalytic subunit Homo sapiens 127-131 31269588-11 2019 Immunofluorescent staining identified that, after transfected with beta-catenin, differentiated cells underwent beta-catenin nuclear translocation and NIS localization transferred from membrane to plasma, compared with cells from untransfected or empty plasmid transfected stem cells. Nickel 151-154 catenin beta 1 Homo sapiens 67-79 30963643-4 2019 The results of spectroscopic studies suggested that the oxidized nickel complex adopts a monomeric structure ([Ni](PF6 )) in CH2 Cl2 , but a dimeric structure ({[Ni](PF6 )}2 ) in the other investigated solvents. Nickel 65-71 sperm associated antigen 17 Homo sapiens 115-118 31111126-4 2019 The cblA gene of a cobalt-dependent transcriptional repressor was shown to be indispensable for nickel-mediated derepression. Nickel 96-102 metabolism of cobalamin associated A Homo sapiens 4-8 31184197-1 2019 A nickel-catalyzed C(sp3)-C(sp2) Suzuki cross-coupling of arylboronic acids and (hetero)naphthyl alcohols has been developed. Nickel 2-8 Sp2 transcription factor Homo sapiens 26-31 31111126-7 2019 We showed this using three variants of NHase in vivo synthesis: by using nickel- or urea-induced synthesis in cblA+ strains, and by using metal-independent constitutive synthesis in cblA- strains. Nickel 73-79 metabolism of cobalamin associated A Homo sapiens 110-114 31111126-11 2019 This suggests that the metal selectivity in cblA-dependent regulation of NHase transcription was too low to discriminate between cobalt and nickel, but the selectivity of the NHase maturation mechanism was high enough to do so. Nickel 140-146 metabolism of cobalamin associated A Homo sapiens 44-48 31073581-2 2019 Reduction reactions are examined and the nickel complexes 8 and 9 ([(NBn-BZIMPY)2Ni][MCl3]2) are isolated from the reaction of Ni(COD)2 with 1 and 2 respectively. Nickel 41-47 nibrin Homo sapiens 69-72 31073581-2 2019 Reduction reactions are examined and the nickel complexes 8 and 9 ([(NBn-BZIMPY)2Ni][MCl3]2) are isolated from the reaction of Ni(COD)2 with 1 and 2 respectively. Nickel 41-47 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 130-148 31249573-0 2019 Identification and Characterization of Circulating Naive CD4+ and CD8+ T Cells Recognizing Nickel. Nickel 91-97 CD4 molecule Homo sapiens 57-60 31249573-0 2019 Identification and Characterization of Circulating Naive CD4+ and CD8+ T Cells Recognizing Nickel. Nickel 91-97 CD8a molecule Homo sapiens 66-69 31249573-4 2019 The purpose of this study was to identify and quantify naive CD4+ and CD8+ T cells recognizing nickel in the general population. Nickel 95-101 CD4 molecule Homo sapiens 61-64 31249573-4 2019 The purpose of this study was to identify and quantify naive CD4+ and CD8+ T cells recognizing nickel in the general population. Nickel 95-101 CD8a molecule Homo sapiens 70-73 31249573-5 2019 Using a T-cell priming in vitro assay based on autologous co-cultures between naive T cells and dendritic cells loaded with nickel, we were able to detect a naive CD4+ and CD8+ T-cell repertoire for nickel in 10/11 and 7/8 of the tested donors. Nickel 124-130 CD4 molecule Homo sapiens 163-166 31249573-5 2019 Using a T-cell priming in vitro assay based on autologous co-cultures between naive T cells and dendritic cells loaded with nickel, we were able to detect a naive CD4+ and CD8+ T-cell repertoire for nickel in 10/11 and 7/8 of the tested donors. Nickel 124-130 CD8a molecule Homo sapiens 172-175 31249573-5 2019 Using a T-cell priming in vitro assay based on autologous co-cultures between naive T cells and dendritic cells loaded with nickel, we were able to detect a naive CD4+ and CD8+ T-cell repertoire for nickel in 10/11 and 7/8 of the tested donors. Nickel 199-205 CD4 molecule Homo sapiens 163-166 31249573-5 2019 Using a T-cell priming in vitro assay based on autologous co-cultures between naive T cells and dendritic cells loaded with nickel, we were able to detect a naive CD4+ and CD8+ T-cell repertoire for nickel in 10/11 and 7/8 of the tested donors. Nickel 199-205 CD8a molecule Homo sapiens 172-175 31249573-6 2019 We calculated a mean frequency of 0.49 nickel-specific naive CD4+ T cells and 0.37 nickel-specific naive CD8+ T cells per million of circulating naive T cells. Nickel 39-45 CD4 molecule Homo sapiens 61-64 31249573-6 2019 We calculated a mean frequency of 0.49 nickel-specific naive CD4+ T cells and 0.37 nickel-specific naive CD8+ T cells per million of circulating naive T cells. Nickel 83-89 CD8a molecule Homo sapiens 105-108 31249573-7 2019 The activation of these specific T cells requires MHC molecules and alongside IFN-gamma production, some nickel-specific T-cells were able to produce granzyme-B. Nickel 105-111 granzyme B Homo sapiens 150-160 31249573-8 2019 Interestingly, nickel-specific naive CD4+ and CD8+ T cells showed a low rate of cross-reactivity with cobalt, another metallic hapten, frequently mixed with nickel in many alloys. Nickel 15-21 CD4 molecule Homo sapiens 37-40 31249573-8 2019 Interestingly, nickel-specific naive CD4+ and CD8+ T cells showed a low rate of cross-reactivity with cobalt, another metallic hapten, frequently mixed with nickel in many alloys. Nickel 15-21 CD8a molecule Homo sapiens 46-49 31249573-8 2019 Interestingly, nickel-specific naive CD4+ and CD8+ T cells showed a low rate of cross-reactivity with cobalt, another metallic hapten, frequently mixed with nickel in many alloys. Nickel 157-163 CD4 molecule Homo sapiens 37-40 31249573-8 2019 Interestingly, nickel-specific naive CD4+ and CD8+ T cells showed a low rate of cross-reactivity with cobalt, another metallic hapten, frequently mixed with nickel in many alloys. Nickel 157-163 CD8a molecule Homo sapiens 46-49 30758762-2 2019 Nickel insertion during maturation of Escherichia coli [NiFe]-hydrogenase 3 is achieved by the metallochaperones HypA, SlyD and the GTPase HypB, but how these proteins cooperate to ensure nickel delivery is not known. Nickel 0-6 hypA Escherichia coli 113-117 30904818-11 2019 Besides, over-expression of miR-206 could notably promoted the expression of NIS, an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, playing a critical role in the progress. Nickel 77-80 microRNA 206 Homo sapiens 28-35 30953872-3 2019 Under the optimized electrocatalytic conditions, the nickel complex immobilized glassy carbon electrodes (GCEs) displayed high sensitivity (0.663, 1.280, 1.990 and 0.182 muA/muM) towards glucose detection, which is much higher than that of 3D porous nickel networks. Nickel 53-59 latexin Homo sapiens 174-177 30707600-3 2019 In this study, PEDV recombinant S1 protein (rS1) was expressed with the Bac-to-Bac system and purified by nickel-affinity chromatography. Nickel 106-112 retinoschisin 1 Rattus norvegicus 32-34 31411588-2 2019 Nano-nickel coated carbon (Ni/C), compared with uncoated carbon (C), has shown a much enhanced (almost 80% higher) tendency of Pb(II) removal from solutions having different acid concentrations. Nickel 5-11 submaxillary gland androgen regulated protein 3B Homo sapiens 127-133 30875446-0 2019 PAd2-DalPhos Enables the Nickel-Catalyzed C-N Cross-Coupling of Primary Heteroarylamines and (Hetero)aryl Chlorides. Nickel 25-31 peptidyl arginine deiminase 2 Homo sapiens 0-4 30950262-2 2019 Herein, we report a highly active and stably heterostructural electrocatalyst consisting of NiCoP nanowires decorated with CoP nanoparticles on a nickel foam (NiCoP-CoP/NF) for effective hydrogen evolution. Nickel 146-152 caspase recruitment domain family member 16 Homo sapiens 94-97 30950262-2 2019 Herein, we report a highly active and stably heterostructural electrocatalyst consisting of NiCoP nanowires decorated with CoP nanoparticles on a nickel foam (NiCoP-CoP/NF) for effective hydrogen evolution. Nickel 146-152 caspase recruitment domain family member 16 Homo sapiens 123-126 30707600-3 2019 In this study, PEDV recombinant S1 protein (rS1) was expressed with the Bac-to-Bac system and purified by nickel-affinity chromatography. Nickel 106-112 retinoschisin 1 Rattus norvegicus 44-47 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 vascular endothelial growth factor A Homo sapiens 15-19 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 AKT serine/threonine kinase 1 Homo sapiens 49-52 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 mitogen-activated protein kinase 3 Homo sapiens 54-60 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 62-70 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 76-80 30724446-3 2019 However, the signal transduction pathways leading to VEGF induction by nickel compounds are not well understood. Nickel 71-77 vascular endothelial growth factor A Homo sapiens 53-57 30885432-7 2019 Finally, we have analysed the effect a variety of heavy metals have on the oligomeric state of Prx, wherein small transition metals like nickel enhances Prx stacking, while larger positively charged metals like tungstate ions can prevent Prx stacking. Nickel 137-143 peroxiredoxin 3 Homo sapiens 95-98 30885432-7 2019 Finally, we have analysed the effect a variety of heavy metals have on the oligomeric state of Prx, wherein small transition metals like nickel enhances Prx stacking, while larger positively charged metals like tungstate ions can prevent Prx stacking. Nickel 137-143 peroxiredoxin 3 Homo sapiens 153-156 30885432-7 2019 Finally, we have analysed the effect a variety of heavy metals have on the oligomeric state of Prx, wherein small transition metals like nickel enhances Prx stacking, while larger positively charged metals like tungstate ions can prevent Prx stacking. Nickel 137-143 peroxiredoxin 3 Homo sapiens 153-156 30938528-5 2019 Overexpression of PPARgamma in MCF-7 cells increased basal NIS-promoter activity, and treatment with the PPARgamma ligand troglitazone stimulated ATRA-induced NIS-promoter activity. Nickel 59-62 peroxisome proliferator activated receptor gamma Homo sapiens 18-27 30938528-5 2019 Overexpression of PPARgamma in MCF-7 cells increased basal NIS-promoter activity, and treatment with the PPARgamma ligand troglitazone stimulated ATRA-induced NIS-promoter activity. Nickel 159-162 peroxisome proliferator activated receptor gamma Homo sapiens 18-27 30938528-5 2019 Overexpression of PPARgamma in MCF-7 cells increased basal NIS-promoter activity, and treatment with the PPARgamma ligand troglitazone stimulated ATRA-induced NIS-promoter activity. Nickel 159-162 peroxisome proliferator activated receptor gamma Homo sapiens 105-114 30938528-6 2019 In conclusion, the results suggest that CLA isomers exert their effect on the expression of NIS by decreasing PPARG expression in MCF-7 cells. Nickel 92-95 peroxisome proliferator activated receptor gamma Homo sapiens 110-115 30960582-1 2019 This work reports the preparation of a hydroxyl terminated polystyrene-b-polybutadiene-b-polystyrene triblock copolymer (SBS) with high cis-1, 4 content via a novel nickel catalyst, [eta3-Ni(CH2CHCHCH2OOCH3)][BPhF4]. Nickel 165-171 suppressor of cytokine signaling 1 Homo sapiens 136-141 31215873-0 2019 [EFFECT OF MANGANESE AND NICKEL ON PROLACTIN LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME]. Nickel 25-31 prolactin Homo sapiens 35-44 30827090-3 2019 A combination of structural, spectroscopic, electrochemical, and computational studies were used to establish the electronic structure of each monomeric [(ipcADI)NiX] (X = Cl, Br, I) complex as a nickel(I) derivative supported by a redox-neutral alpha-diimine chelate. Nickel 196-202 BCL2 interacting protein 3 like Homo sapiens 162-165 30918251-2 2019 Here, we report atomically dispersed nickel coordinated with nitrogen and sulfur species in porous carbon nanosheets as an electrocatalyst exhibiting excellent activity and durability for OER with a low overpotential of 1.51 V at 10 mA cm-2 and a small Tafel slope of 45 mV dec-1 in alkaline media. Nickel 37-43 deleted in esophageal cancer 1 Homo sapiens 274-279 30917615-6 2019 I further describe the crucial role of prolactin and megalin in regulation of NIS expression and iodine homeostasis and the effect of fluoride in down regulating prolactin and megalin expression. Nickel 78-81 LDL receptor related protein 2 Homo sapiens 53-60 30884885-9 2019 Whereas MT-1G was also induced by zinc and nickel ions and MT-1H by iron, both MT-1A and MT-1M were highly cadmium-specific, which was confirmed for protein using isoform-specific antibodies. Nickel 43-49 metallothionein 1G Homo sapiens 8-13 30880979-4 2019 We also examined radioiodine uptake in Huh7 cells treated with EV-Huh7/NIS. Nickel 71-74 MIR7-3 host gene Homo sapiens 39-43 30880979-5 2019 Results: Successful transfer of NIS protein into Huh7 cells was confirmed by WB and microscopy. Nickel 32-35 MIR7-3 host gene Homo sapiens 49-53 30880979-7 2019 Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. Nickel 37-40 MIR7-3 host gene Homo sapiens 13-17 30880979-7 2019 Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. Nickel 55-58 MIR7-3 host gene Homo sapiens 13-17 30880979-7 2019 Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. Nickel 55-58 MIR7-3 host gene Homo sapiens 32-36 30880979-7 2019 Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. Nickel 55-58 MIR7-3 host gene Homo sapiens 32-36 31148973-8 2019 Exposure to nickel induced expression of CD69 on a significantly higher proportion of CD4+ lymphocytes (22.1+-6.2%) of the ACD patients compared to controls (2.8+-2.5%;p<0.0001). Nickel 12-18 CD4 molecule Homo sapiens 86-89 31148973-9 2019 Similarly nickel induced CD69 expression on a higher proportion of CD8+ lymphocytes (18.2+-5.3%) from ACD patients compared to the controls (1.9+-1.8%;p<0.0006). Nickel 10-16 CD8a molecule Homo sapiens 67-70 30426511-1 2019 BACKGROUND: Nickel allergy and dermatitis have been associated with filaggrin gene mutations in epidemiological studies, but the mechanisms mediating these associations are unknown. Nickel 12-18 filaggrin Mus musculus 68-77 30426511-2 2019 OBJECTIVES: To investigate whether filaggrin-deficient flaky tail (ft/ft) mice show increased immune reactivity to nickel and elucidate the mechanisms mediating this. Nickel 115-121 filaggrin Mus musculus 35-44 30426511-8 2019 Blocking either the IL-17A pathway or the IL-1 pathway reduced nickel responsiveness in ft/ft mice. Nickel 63-69 interleukin 17A Mus musculus 20-26 30426511-9 2019 CONCLUSIONS: These findings suggest that the increased nickel responsiveness associated with epidermal filaggrin deficiency is mediated by a combination of increased nickel penetration and the steady-state inflammation found in the skin of filaggrin-deficient mice. Nickel 55-61 filaggrin Mus musculus 103-112 30426511-9 2019 CONCLUSIONS: These findings suggest that the increased nickel responsiveness associated with epidermal filaggrin deficiency is mediated by a combination of increased nickel penetration and the steady-state inflammation found in the skin of filaggrin-deficient mice. Nickel 166-172 filaggrin Mus musculus 103-112 30881348-9 2019 In vitro, we generated a stable thyroid cell line PCCL3 with FAM83F overexpression and observed that FAM83F deregulates thyroid follicular cell biology leading to loss of thyroid differentiation genes such as Sodium-Iodide Symporter (NIS), reactivation of stem cell markers such as LIN28B and SOX2, induction of cell migration and resistance to doxorubicin-induced apoptosis. Nickel 234-237 family with sequence similarity 83 member F Homo sapiens 101-107 30549005-0 2019 The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis. Nickel 56-62 interleukin 17A Homo sapiens 19-24 30414969-7 2019 Recombinant TNFR1-ECD was refolded and purified via nickel-affinity chromatography, tag cleavage, followed by cation-exchange chromatography or size-exclusion chromatography. Nickel 52-58 TNF receptor superfamily member 1A Homo sapiens 12-17 30668110-4 2019 TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive "membrane-bound" state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules. Nickel 49-55 TNF superfamily member 10 Homo sapiens 0-5 30668110-4 2019 TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive "membrane-bound" state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules. Nickel 49-55 TNF superfamily member 10 Homo sapiens 183-188 30624456-6 2019 However, a tenfold lower concentration of nickel decreases the apparent calcium-binding affinity and calcium-induced dimerization of N-cadherin. Nickel 42-48 cadherin 2 Homo sapiens 133-143 30729243-0 2019 Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles. Nickel 86-92 C-X-C motif chemokine receptor 4 Homo sapiens 39-44 30729243-10 2019 These results provide insight for generation of optimised bis-macrocyclic CXCR4 antagonists utilising cobalt and nickel ions. Nickel 113-119 C-X-C motif chemokine receptor 4 Homo sapiens 74-79 30707014-3 2019 The following new nickel precursor complexes were characterized: PPh4[Ni(NS3)] and the dimeric imino/amino-phosphine complexes [NiCl2(PCH NAn)]2 and [NiCl2(PCH2NHAn)]2 (P = Ph2PC6H4-2-). Nickel 18-24 potassium two pore domain channel subfamily K member 3 Homo sapiens 65-69 30960324-7 2019 The maximum sorption capacities obtained (at pH 4) were 197 mg g-1 and 44 mg g-1 for lead and nickel, respectively. Nickel 94-100 proline rich protein BstNI subfamily 3 Homo sapiens 63-80 30760301-5 2019 Zip code residential levels of airborne PAHs and metals (arsenic, cadmium, chromium, cobalt, lead, manganese, mercury, nickel, and selenium) were assessed using the 2011 EPA National Air Toxics Assessment. Nickel 119-125 death associated protein kinase 3 Homo sapiens 0-3 30847387-6 2019 Combined treatment with panobinostat and MAPKi (dabrafenib or selumetinib) displayed a more robust BRAF V600E-dependent redifferentiation effect than panobinostat alone via further improving the acetylation level of histone at the sodium-iodide symporter (NIS) promoter. Nickel 256-259 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 99-103 28990511-5 2019 RESULTS: In vitro studies showed that sunitinib targeted the cytosolic MEK/ERK and SAPK/JNK pathways in the RET/PTC1 cell inhibiting cell proliferation and causing stimulation of sodium/iodide symporter (NIS) gene expression in RET/PTC1 cells. Nickel 204-207 ret proto-oncogene Homo sapiens 108-111 30600933-2 2019 Herein, Nix Co3-x O4 nanoneedle arrays grown on 3D porous nickel foam (NF) was synthesized as a bifunctional electrocatalyst with OER and HER activity for full water splitting. Nickel 58-64 BCL2 interacting protein 3 like Homo sapiens 8-11 29754191-4 2019 For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD. Nickel 13-19 negative elongation factor complex member C/D Homo sapiens 36-39 30470900-4 2019 In the general frame of the NCS often observed in crystals of biomolecules, this paper deals with nickel(II)-substituted human carbonic anhydrase(II) (hCAII) and its SAD structure determination at the nickel edge. Nickel 98-104 carbonic anhydrase 2 Homo sapiens 127-149 30470900-4 2019 In the general frame of the NCS often observed in crystals of biomolecules, this paper deals with nickel(II)-substituted human carbonic anhydrase(II) (hCAII) and its SAD structure determination at the nickel edge. Nickel 98-104 carbonic anhydrase 2 Homo sapiens 151-156 30468944-7 2019 In particular, recent studies on the interactions of amylin with copper, zinc, iron, nickel, gold, ruthenium, and vanadium are discussed. Nickel 85-91 islet amyloid polypeptide Homo sapiens 53-59 30513368-3 2019 The recombinant P. pastoris was inoculated in to BMMY culture medium, incubation with 5 mul/ml absolute methanol for 72 h at 30 C. The TC-1 peptide was concentrated with nickel affinity chromatography and electrophoresis on 16% acrylamide gels. Nickel 171-177 pro-platelet basic protein Homo sapiens 136-140 30673257-0 2019 One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling. Nickel 24-30 Sp2 transcription factor Homo sapiens 57-60 30673257-0 2019 One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling. Nickel 24-30 Sp3 transcription factor Homo sapiens 61-64 30673257-1 2019 A one-pot electrochemical nickel-catalyzed decarboxylative sp2-sp3 cross-coupling reaction has been developed using redox-active esters prepared in situ from alkyl carboxylates and N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (PITU). Nickel 26-32 Sp2 transcription factor Homo sapiens 59-62 30673257-1 2019 A one-pot electrochemical nickel-catalyzed decarboxylative sp2-sp3 cross-coupling reaction has been developed using redox-active esters prepared in situ from alkyl carboxylates and N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (PITU). Nickel 26-32 Sp3 transcription factor Homo sapiens 63-66 30937261-4 2019 Octet-truss structures with nickel-iron-(oxo) hydroxide nanosheets electrodeposited onto further displays excellent water-splitting performance as catalytic electrodes, i.e., in KOH (1 m, aq), a low oxygen evolution reaction (OER) overpotential of 197 mV at 10 mA cm-2 and Tafel slope of 51 mV dec-1. Nickel 28-34 deleted in esophageal cancer 1 Homo sapiens 294-299 29558102-1 2019 We employed a two-step strategy for preparing ultrathin graphdiyne-wrapped iron carbonate hydroxide nanosheets on nickel foam (FeCH@GDY/NF) as the efficient catalysts toward the electrical splitting water. Nickel 114-120 ferrochelatase Homo sapiens 127-131 30566142-6 2019 However, chelate-chelate stacking is stronger for dithiolene nickel chelate than for acac-type nickel chelate, which has a CCSD(T)/CBS interaction energy of -9.50 kcal mol-1. Nickel 61-67 cystathionine beta-synthase Homo sapiens 131-134 30608102-0 2019 Nickel-catalyzed syn-stereocontrolled ring-opening of oxa- and azabicyclic alkenes with dialkylzinc reagents. Nickel 0-6 synemin Homo sapiens 17-20 30608102-1 2019 A new nickel-catalyzed syn-stereocontrolled ring-opening of oxa- and azabicyclic alkenes with dialkylzinc reagents was developed, which afforded the corresponding cis-2-alkyl-1,2-dihydronaphthalen-1-ols and 1,2-alkyl amide derivatives in moderate to excellent yields (up to 99% yield) under mild conditions. Nickel 6-12 synemin Homo sapiens 23-26 30565909-0 2019 Nickel Nanowires Combined with Surface-Enhanced Raman Spectroscopy: Application in Label-Free Detection of Cytochrome c-Mediated Apoptosis. Nickel 0-6 cytochrome c, somatic Homo sapiens 107-119 30565909-2 2019 In this study, nickel nanowires (Ni NWs) as electron donors for oxidized cytochrome c (Cyt c) are investigated, which are NW diameter, temperature, and pH value-dependent. Nickel 15-21 cytochrome c, somatic Homo sapiens 73-85 30565909-2 2019 In this study, nickel nanowires (Ni NWs) as electron donors for oxidized cytochrome c (Cyt c) are investigated, which are NW diameter, temperature, and pH value-dependent. Nickel 15-21 cytochrome c, somatic Homo sapiens 87-92 30316800-8 2019 We observed that iodine increased NOX4 expression and knockdown of NOX4 reduced ROS and reversed the inhibitory effect of iodine on NIS, TPO, PAX8 and TTF2 expression. Nickel 132-135 NADPH oxidase 4 Rattus norvegicus 67-71 30626049-5 2019 NMR-Spectroscopic and crystallographic analysis of the obtained complexes clearly show that the dimetallic cobalt and molybdenum complexes cause rehybridization of the alkyne carbon atoms to sp3, while in the nickel complexes one pi-bond of the alkyne is retained. Nickel 209-215 Sp3 transcription factor Homo sapiens 191-194 30621196-0 2019 The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study. Nickel 67-73 NK2 homeobox 1 Homo sapiens 25-31 30621196-3 2019 Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Nickel 39-45 SMAD family member 2 Homo sapiens 126-131 30621196-3 2019 Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Nickel 39-45 NK2 homeobox 1 Homo sapiens 159-165 30621196-8 2019 Nkx2.1 (rs = 0.312, p < 0.001) and Smad2 phosphorylation levels (rs = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Nickel 148-154 NK2 homeobox 1 Homo sapiens 0-6 30621196-8 2019 Nkx2.1 (rs = 0.312, p < 0.001) and Smad2 phosphorylation levels (rs = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Nickel 148-154 SMAD family member 2 Homo sapiens 38-43 30621196-9 2019 Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Nickel 125-131 NK2 homeobox 1 Homo sapiens 19-25 30621196-10 2019 Conclusions: Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change. Nickel 26-32 NK2 homeobox 1 Homo sapiens 75-81 30621196-10 2019 Conclusions: Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change. Nickel 120-126 NK2 homeobox 1 Homo sapiens 75-81 30534670-2 2019 After activation of methylaluminoxane (MAO), all the nickel and palladium complexes could catalyze the polymerization of norbornene to yield vinyl-type polymers with activities up to 40.3 x 105 g of PNB (mol of Pd)-1 h-1. Nickel 53-59 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 211-213 30326385-6 2019 The effect of nickel and cobalt - previously reported to activate the hTLR4/MD-2 complex - was found to be negligible in comparison to that of iron. Nickel 14-20 toll like receptor 4 Homo sapiens 70-75 30326385-6 2019 The effect of nickel and cobalt - previously reported to activate the hTLR4/MD-2 complex - was found to be negligible in comparison to that of iron. Nickel 14-20 lymphocyte antigen 96 Homo sapiens 76-80 30328813-0 2019 Quantitative, Absolute Count-Based T-Cell Analysis of CD69 Upregulation as a New Methodology for In Vitro Diagnosis of Delayed-Type Hypersensitivity Reaction to Nickel. Nickel 161-167 CD69 molecule Homo sapiens 54-58 30328813-3 2019 The aim of our study was to develop a novel, whole blood-based, quantitative, absolute count activation index (AI) for analysis of CD69 upregulation in various subsets of T cells in nickel-hypersensitive patients and compare it with previously reported approaches. Nickel 182-188 CD69 molecule Homo sapiens 131-135 30328813-9 2019 The index was calculated as the ratio of the absolute count of nickel-stimulated CD69-positive T cells to the absolute count of CD69-positive T cells in nonstimulated blood. Nickel 63-69 CD69 molecule Homo sapiens 81-85 30328813-11 2019 CONCLUSIONS: Our results demonstrated that measuring the absolute CD69 AI is a novel and accurate approach for quantification of antigen-specific T cells in the blood of patients with hypersensitivity reactions to nickel. Nickel 214-220 CD69 molecule Homo sapiens 66-70 30224540-1 2019 The sodium iodide symporter (SLC5A5/NIS) as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Nickel 36-39 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 4-27 30224540-1 2019 The sodium iodide symporter (SLC5A5/NIS) as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Nickel 112-115 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 4-27 30224540-1 2019 The sodium iodide symporter (SLC5A5/NIS) as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Nickel 112-115 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 29-35 30224540-8 2019 Furthermore, IHC analysis of alpha-SMA and Ki67 revealed differences in the amount and behavior of activated fibroblasts in tumors of mice injected with NIS-MSCs as compared with saline-treated mice. Nickel 153-156 antigen identified by monoclonal antibody Ki 67 Mus musculus 43-47 31227679-4 2019 OBJECTIVE: In this study, AChE activity was assessed in occupational exposure to chromium (VI) and co-exposure to nickel (II) and chromium (VI). Nickel 114-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30489077-0 2018 Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids. Nickel 0-6 synemin Homo sapiens 17-20 30421605-4 2018 We previously showed that nickel can upregulate the production of IL-12p40 and IL-23, both known to be pro-inflammatory. Nickel 26-32 interleukin 23 subunit alpha Homo sapiens 79-84 30421605-5 2018 In this work, we aimed to extend our knowledge on nickel regulation of the IL-12 cytokine family by focusing on IL-27, a recently identified immunomodulatory cytokine from this family. Nickel 50-56 interleukin 27 Homo sapiens 112-117 30421605-6 2018 We showed that nickel induced the production of IL-27 in human monocyte-derived DC (MoDC), regulating IL-22 production by human CD4+ T cells. Nickel 15-21 interleukin 27 Homo sapiens 48-53 30421605-6 2018 We showed that nickel induced the production of IL-27 in human monocyte-derived DC (MoDC), regulating IL-22 production by human CD4+ T cells. Nickel 15-21 interleukin 22 Homo sapiens 102-107 30421605-7 2018 We also showed that nickel was able to induce the expression of the two subunits of IL-27: il-27p28 and ebi3. Nickel 20-26 interleukin 27 Homo sapiens 84-89 30421605-7 2018 We also showed that nickel was able to induce the expression of the two subunits of IL-27: il-27p28 and ebi3. Nickel 20-26 interleukin 27 Homo sapiens 91-99 30421605-7 2018 We also showed that nickel was able to induce the expression of the two subunits of IL-27: il-27p28 and ebi3. Nickel 20-26 Epstein-Barr virus induced 3 Homo sapiens 104-108 30421605-11 2018 Our results contribute to a better understanding of nickel-induced ACD by focusing on the IL-12 cytokine family and elucidating the mechanism of IL-27 regulation in human dendritic cells. Nickel 52-58 interleukin 27 Homo sapiens 145-150 30557354-10 2018 Characterization of the T-cell receptor repertoire in nickel allergic mice revealed the presence of natural killer T cells and T cells bearing Trav6-6-Traj57 at 1 day after the challenge. Nickel 54-60 T cell receptor alpha variable 6-6 Mus musculus 143-150 30557354-10 2018 Characterization of the T-cell receptor repertoire in nickel allergic mice revealed the presence of natural killer T cells and T cells bearing Trav6-6-Traj57 at 1 day after the challenge. Nickel 54-60 T cell receptor alpha joining 57 Mus musculus 151-157 30557354-11 2018 Our murine model of nickel-induced intraoral metal contact allergy showed that natural killer T cells and T cells bearing Trav6-6-Traj57 might be involved in the immune responses of nickel-induced intraoral metal contact allergy. Nickel 20-26 T cell receptor alpha variable 6-6 Mus musculus 122-129 30557354-11 2018 Our murine model of nickel-induced intraoral metal contact allergy showed that natural killer T cells and T cells bearing Trav6-6-Traj57 might be involved in the immune responses of nickel-induced intraoral metal contact allergy. Nickel 20-26 T cell receptor alpha joining 57 Mus musculus 130-136 30557354-11 2018 Our murine model of nickel-induced intraoral metal contact allergy showed that natural killer T cells and T cells bearing Trav6-6-Traj57 might be involved in the immune responses of nickel-induced intraoral metal contact allergy. Nickel 182-188 T cell receptor alpha variable 6-6 Mus musculus 122-129 30557354-11 2018 Our murine model of nickel-induced intraoral metal contact allergy showed that natural killer T cells and T cells bearing Trav6-6-Traj57 might be involved in the immune responses of nickel-induced intraoral metal contact allergy. Nickel 182-188 T cell receptor alpha joining 57 Mus musculus 130-136 30431281-0 2018 Nickel-Catalyzed Cyanation of Unactivated Alkyl Chlorides or Bromides with Zn(CN)2. Nickel 0-6 carnosine dipeptidase 2 Homo sapiens 75-82 30431281-1 2018 A nickel-catalyzed cyanation of unactivated secondary alkyl chlorides or bromides using less toxic Zn(CN)2 as the cyanide source has been developed. Nickel 2-8 carnosine dipeptidase 2 Homo sapiens 99-106 30431281-3 2018 Cyanation of primary alkyl chlorides or bromides was also achieved by reaction with Zn(CN)2 in the presence of n-Bu4NCl without the need of nickel catalyst. Nickel 140-146 carnosine dipeptidase 2 Homo sapiens 84-91 30467570-1 2018 We investigate the spin-dependent electronic and transport properties of armchair graphene nanoribbons including spin-orbit coupling due to the presence of nickel and iridium adatoms by using ab initio calculations within the spin-polarized density functional theory and non-equilibrium Green"s function formalism. Nickel 156-162 spindlin 1 Homo sapiens 19-23 30467570-1 2018 We investigate the spin-dependent electronic and transport properties of armchair graphene nanoribbons including spin-orbit coupling due to the presence of nickel and iridium adatoms by using ab initio calculations within the spin-polarized density functional theory and non-equilibrium Green"s function formalism. Nickel 156-162 spindlin 1 Homo sapiens 113-117 30467570-1 2018 We investigate the spin-dependent electronic and transport properties of armchair graphene nanoribbons including spin-orbit coupling due to the presence of nickel and iridium adatoms by using ab initio calculations within the spin-polarized density functional theory and non-equilibrium Green"s function formalism. Nickel 156-162 spindlin 1 Homo sapiens 113-117 30518079-2 2018 In this work, we immobilized (His)6-rHbI over a surface modified with gold nanoparticles functionalized with 3-mercaptopropionic acid complexed with nickel ion. Nickel 149-155 FKBP prolyl isomerase 4 Rattus norvegicus 36-40 30422643-2 2018 This strategy enables the sustained performance of copper catalysts in distilled and tap water electrolytes for over 12 h. The deposition of common electrolyte impurities such as iron, nickel, and zinc is blocked because EDTA can effectively bind the metal ions and negatively shift the electrode potential of M/M n+. Nickel 185-191 SEC14 like lipid binding 2 Homo sapiens 85-88 31168208-6 2018 Also, in allergic CD skin lesions, the skin shows different types of immune responses to individual allergens, although clinical manifestations do not depend on the causative allergen type, e.g., nickel stimulates immune activation primarily of the Th1/Th17 and Th22 components. Nickel 196-202 negative elongation factor complex member C/D Homo sapiens 249-252 30080550-4 2018 The novel nickel catalyst prepared and characterized by FT-IR, XRD, SEM, EDX, TGA and VSM techniques. Nickel 10-16 T-box transcription factor 1 Homo sapiens 78-81 30397317-6 2018 Genetic engineering enabled the site-specific attachment of a nickel-terpyridine complex and the modular optimization of the photochemical properties of PSP, the chromophore/catalytic centre distance and the catalytic centre microenvironment, which culminated in a miniature photocatalytic CO2-reducing enzyme that has a CO2/CO conversion quantum efficiency of 2.6%. Nickel 62-68 microseminoprotein beta Homo sapiens 153-156 30774893-2 2019 Si-Me4-DHP was found to function as a reductant for generating nickel(0) species and a silylation reagent to achieve the catalytic cyanation via C-CN bond cleavage. Nickel 63-69 dihydropyrimidinase Homo sapiens 7-10 30403224-1 2018 A bidentate directing group enabled regioselective arylation of C(sp2)-H bonds in aromatic carboxamides with aryl iodides under nickel-catalysis is reported, which provides the corresponding products in moderate to good yields. Nickel 128-134 Sp2 transcription factor Homo sapiens 64-69 30039502-9 2018 CONCLUSION: There is a significant decrease in the number of adherent CD61 +ve platelets on nickel titanium surfaces coated with the HPC-II coating compared to uncoated surfaces. Nickel 92-98 integrin subunit beta 3 Homo sapiens 70-74 30382103-0 2018 syn-Selective alkylarylation of terminal alkynes via the combination of photoredox and nickel catalysis. Nickel 87-93 synemin Homo sapiens 0-3 30356071-0 2018 Enrichment and Quantification of Epitope-specific CD4+ T Lymphocytes using Ferromagnetic Iron-gold and Nickel Nanowires. Nickel 103-109 CD4 molecule Homo sapiens 50-53 30746080-2 2019 Deuterium-labeling experiments and control experiments were conducted to probe the mechanism, and the results indicated that the acidity of the solvent plays a critical role in the control of diastereoselectivity by trapping the adduct of nickel hydride to C[double bond, length as m-dash]C bonds via protonolysis, giving the hydrogenation product with stereospecific syn-selectivity. Nickel 239-245 synemin Homo sapiens 368-371 30337961-0 2018 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. Nickel 107-110 mitogen-activated protein kinase kinase 7 Homo sapiens 26-29 30337961-0 2018 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. Nickel 107-110 mitogen-activated protein kinase 1 Homo sapiens 30-33 30337961-0 2018 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. Nickel 107-110 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 38-42 30337961-0 2018 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. Nickel 107-110 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 149-153 30337961-3 2018 Use of BRAF V600E inhibitors could partly restore NIS expression and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) pathway. Nickel 50-53 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 7-11 30337961-3 2018 Use of BRAF V600E inhibitors could partly restore NIS expression and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) pathway. Nickel 50-53 mitogen-activated protein kinase 3 Homo sapiens 134-138 30337961-5 2018 In the present study, we investigated whether the combination treatment of BRAF V600E inhibitor and MAPK signal inhibitor could more effectively increase NIS expression and RAI uptake, and explore the mechanisms. Nickel 154-157 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 75-79 30337961-5 2018 In the present study, we investigated whether the combination treatment of BRAF V600E inhibitor and MAPK signal inhibitor could more effectively increase NIS expression and RAI uptake, and explore the mechanisms. Nickel 154-157 mitogen-activated protein kinase 3 Homo sapiens 100-104 30337961-11 2018 Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression. Nickel 69-72 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 39-43 30337961-11 2018 Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression. Nickel 69-72 mitogen-activated protein kinase 1 Homo sapiens 56-59 30337961-11 2018 Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression. Nickel 69-72 mitogen-activated protein kinase 1 Homo sapiens 166-169 30239626-0 2018 A molecular mechanism of nickel (II): reduction of nucleotide excision repair activity by structural and functional disruption of p53. Nickel 25-31 tumor protein p53 Homo sapiens 130-133 30179005-1 2018 A nickel-catalyzed cyanation reaction of benzylic and allylic pivalate esters is reported using an air-stable Ni(II) precatalyst and substoichiometric quantities of Zn(CN)2. Nickel 2-8 carnosine dipeptidase 2 Homo sapiens 165-172 30199250-4 2018 The hydrogen transfer process in the oxidative addition step is rate-determining in the whole catalytic cycle, which is accomplished by C-Ha (active Ha) activation without generating the high energy nickel hydride intermediate. Nickel 199-213 transcription factor like 5 Homo sapiens 136-140 30199618-8 2018 The bilayer structure of SnO/SnO2 was successfully fabricated on indium tin oxide (ITO) glass with nickel as a top electrode at 100 C. The SnO/SnO2 bilayer exhibited diode characteristics with a current rectification ratio of 15. Nickel 99-105 strawberry notch homolog 2 Homo sapiens 25-28 30199618-8 2018 The bilayer structure of SnO/SnO2 was successfully fabricated on indium tin oxide (ITO) glass with nickel as a top electrode at 100 C. The SnO/SnO2 bilayer exhibited diode characteristics with a current rectification ratio of 15. Nickel 99-105 strawberry notch homolog 2 Homo sapiens 29-32 31950608-1 2018 This study reports the synthesis of hierarchical NiCoO2 nanosheets growing on hollow carbon spheres (denoted as NiCoO2 NSs@HCS) via a facile and low-cost process. Nickel 49-55 holocarboxylase synthetase Homo sapiens 123-126 29777899-8 2018 A homozygous mutation of the intron 9 splice acceptor site of SLC5A5 gene, encoding the sodium/iodine symporter (NIS), was found in the DNA of one of the affected dogs. Nickel 113-116 solute carrier family 5 member 5 Canis lupus familiaris 62-68 29886393-3 2018 The BET surface area of TiO2/MWCNTs/Al2O3/NF composite filter is more than 375 times higher than that of the pristine nickel foam. Nickel 118-124 delta/notch like EGF repeat containing Homo sapiens 4-7 30055191-0 2018 Reversal of Sp1 transactivation and TGFbeta1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation. Nickel 76-82 transforming growth factor beta 1 Homo sapiens 36-44 30055191-0 2018 Reversal of Sp1 transactivation and TGFbeta1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation. Nickel 76-82 SMAD family member 1 Homo sapiens 45-50 30055191-4 2018 Here, we showed that a lower dose of nickel (200 muM) induced the activation of human fibroblast cells, as evidenced by increased cell growth, migration and higher expressions of alpha-smooth muscle actin (alphaSMA) and fibronectin, while high dose of nickel (1 mM) inhibited cell viability. Nickel 37-43 fibronectin 1 Homo sapiens 220-231 30055191-6 2018 Nickel also repressed the mRNA and protein expression of cystathionine gamma-lyase (CSE, a H2S-generating gene) and blocked the endogenous production of H2S. Nickel 0-6 cystathionine gamma-lyase Homo sapiens 57-82 30055191-6 2018 Nickel also repressed the mRNA and protein expression of cystathionine gamma-lyase (CSE, a H2S-generating gene) and blocked the endogenous production of H2S. Nickel 0-6 cystathionine gamma-lyase Homo sapiens 84-87 30055191-9 2018 Moreover, H2S incubation reversed nickel-stimulated TGFbeta1/SMAD1 signal and blocked TGFbeta1-initiated expressions of alphaSMA and fibronectin. Nickel 34-40 transforming growth factor beta 1 Homo sapiens 52-60 30055191-9 2018 Moreover, H2S incubation reversed nickel-stimulated TGFbeta1/SMAD1 signal and blocked TGFbeta1-initiated expressions of alphaSMA and fibronectin. Nickel 34-40 SMAD family member 1 Homo sapiens 61-66 30055191-10 2018 Nickel inhibited the interaction of Sp1 with CSE promoter but strengthened the binding of Sp1 with TGFbeta1 promoter, which was reversed by exogenously applied NaHS. Nickel 0-6 cystathionine gamma-lyase Homo sapiens 45-48 30055191-10 2018 Nickel inhibited the interaction of Sp1 with CSE promoter but strengthened the binding of Sp1 with TGFbeta1 promoter, which was reversed by exogenously applied NaHS. Nickel 0-6 transforming growth factor beta 1 Homo sapiens 99-107 30055191-11 2018 These data reveal that H2S protects from nickel-stimulated fibroblast activation and CSE/H2S system can be a potential target for the treatment of tissue fibrosis induced by nickel. Nickel 174-180 cystathionine gamma-lyase Homo sapiens 85-88 30153002-4 2018 Demonstration of catalytic alkene prefunctionalization, via spectroscopic observation of an organocobalt species, distinguishes this Csp2-Csp3 cross-coupling method from a conventional transmetalation process, which employs a stoichiometric organometallic nucleophile, and from a bimetallic oxidative addition of an organohalide across nickel, described by radical scission and subsequent alkyl radical capture at a second nickel center. Nickel 336-342 regulator of calcineurin 2 Homo sapiens 133-137 30153002-4 2018 Demonstration of catalytic alkene prefunctionalization, via spectroscopic observation of an organocobalt species, distinguishes this Csp2-Csp3 cross-coupling method from a conventional transmetalation process, which employs a stoichiometric organometallic nucleophile, and from a bimetallic oxidative addition of an organohalide across nickel, described by radical scission and subsequent alkyl radical capture at a second nickel center. Nickel 423-429 regulator of calcineurin 2 Homo sapiens 133-137 30184423-0 2018 sp3 C-H Arylation and Alkylation Enabled by the Synergy of Triplet Excited Ketones and Nickel Catalysts. Nickel 87-93 Sp3 transcription factor Homo sapiens 0-3 30184423-3 2018 Herein, we unlock a modular photochemical platform for forging C( sp3)-C( sp2) and C( sp3)-C( sp3) linkages from abundant alkane sp3 C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. Nickel 191-197 Sp3 transcription factor Homo sapiens 66-69 30184423-3 2018 Herein, we unlock a modular photochemical platform for forging C( sp3)-C( sp2) and C( sp3)-C( sp3) linkages from abundant alkane sp3 C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. Nickel 191-197 Sp2 transcription factor Homo sapiens 74-77 30184423-3 2018 Herein, we unlock a modular photochemical platform for forging C( sp3)-C( sp2) and C( sp3)-C( sp3) linkages from abundant alkane sp3 C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. Nickel 191-197 Sp3 transcription factor Homo sapiens 86-89 30184423-3 2018 Herein, we unlock a modular photochemical platform for forging C( sp3)-C( sp2) and C( sp3)-C( sp3) linkages from abundant alkane sp3 C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. Nickel 191-197 Sp3 transcription factor Homo sapiens 86-89 30184423-3 2018 Herein, we unlock a modular photochemical platform for forging C( sp3)-C( sp2) and C( sp3)-C( sp3) linkages from abundant alkane sp3 C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. Nickel 191-197 Sp3 transcription factor Homo sapiens 86-89 31950608-1 2018 This study reports the synthesis of hierarchical NiCoO2 nanosheets growing on hollow carbon spheres (denoted as NiCoO2 NSs@HCS) via a facile and low-cost process. Nickel 112-118 holocarboxylase synthetase Homo sapiens 123-126 31950608-2 2018 When evaluated as anode materials for lithium-ion batteries, the as-prepared NiCoO2 NSs@HCS exhibits high specific capacity, enhanced cycling stability, and good rate capability. Nickel 77-83 holocarboxylase synthetase Homo sapiens 88-91 31950608-4 2018 The hierarchical and hollow structure of NiCoO2 NSs@HCS plays a role in its excellent performance. Nickel 41-47 holocarboxylase synthetase Homo sapiens 52-55 29931256-0 2018 A molecular mechanism of nickel (II): reduction of nucleotide excision repair activity by structural and functional disruption of p53. Nickel 25-31 tumor protein p53 Homo sapiens 130-133 29931256-3 2018 Here, we investigated whether low concentrations of nickel would affect p53-mediated DNA repair, especially nucleotide excision repair. Nickel 52-58 tumor protein p53 Homo sapiens 72-75 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 24-30 tumor protein p53 Homo sapiens 74-77 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 24-30 growth arrest and DNA damage inducible alpha Homo sapiens 101-108 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 24-30 tumor protein p53 Homo sapiens 144-147 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 167-173 tumor protein p53 Homo sapiens 74-77 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 167-173 growth arrest and DNA damage inducible alpha Homo sapiens 101-108 29931256-4 2018 Our results showed that nickel inhibited the promoter binding activity of p53 on the downstream gene GADD45A, as a result of the disturbance of p53 oligomerization by nickel. Nickel 167-173 tumor protein p53 Homo sapiens 144-147 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 34-40 growth arrest and DNA damage inducible alpha Homo sapiens 75-82 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 34-40 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 34-40 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 34-40 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 389-395 growth arrest and DNA damage inducible alpha Homo sapiens 75-82 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 389-395 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 389-395 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-5 2018 In addition, we demonstrated that nickel exposure trigger the reduction of GADD45A-mediated DNA repair by impairing the physical interactions between GADD45A and proliferating cell nuclear antigen or xeroderma pigmentosum G. Notably, in the GADD45A-knockdown system, the levels of unrepaired DNA photoproducts were higher than wild-type cells, elucidating the importance of GADD45A in the nickel-associated inhibition of DNA repair. Nickel 389-395 growth arrest and DNA damage inducible alpha Homo sapiens 150-157 29931256-6 2018 These results imply that inhibition of p53-mediated DNA repair can be considered a potential carcinogenic mechanism of nickel at low concentrations. Nickel 119-125 tumor protein p53 Homo sapiens 39-42 30168331-0 2018 Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation. Nickel 0-6 regulator of calcineurin 2 Homo sapiens 17-21 30651965-4 2018 The detailed electrochemical reaction mechanism investigated by in situ XRD further indicates that the 3D architecture of Ni(HCO3)2/rGO not only provides a good conductivity network and has a confinement effect on the rGO films, but also benefits from the reversible transfer from LiHCO3 to Li x C2 (x = 0-2), further oxidation of nickel, and the formation of a stable/durable solid electrolyte interface (SEI) film (LiF and LiOH), which are responsible for the excellent storage performance of the Li-ions. Nickel 331-337 LIF interleukin 6 family cytokine Homo sapiens 417-420 30156112-5 2018 Spin states in the nickel-manganese ferrite were polarized by two different chiral configurations, i.e., right-handed and left-handed, of the spiral magnetic vector potential, through the Aharonov-Bohm (AB) effect. Nickel 19-25 spindlin 1 Homo sapiens 0-4 30113165-3 2018 Herein, the coordination chemistry of chelating ligands with a diphosphine imine framework (PCNP) to nickel is investigated. Nickel 101-107 PEST proteolytic signal containing nuclear protein Homo sapiens 92-96 30113165-8 2018 In one of them, the imine adopts an uncommon eta1(N)eta2(C,N) bridging mode of the ligand to nickel, while the second one may involve reactivity on the ligand by the formation of a new C-C bond by oxidative coupling. Nickel 93-99 secreted phosphoprotein 1 Homo sapiens 45-49 30113165-8 2018 In one of them, the imine adopts an uncommon eta1(N)eta2(C,N) bridging mode of the ligand to nickel, while the second one may involve reactivity on the ligand by the formation of a new C-C bond by oxidative coupling. Nickel 93-99 DNA polymerase iota Homo sapiens 52-56 30323976-8 2018 This mutant RasGRP3 activated the Akt pathway, promoted thyroid cancer cell proliferation and invasion, and reduced NIS expression and the iodine uptake ability. Nickel 116-119 RAS guanyl releasing protein 3 Homo sapiens 12-19 29682887-9 2018 Finally, exposure to eluants from nickel-based commercial alloys caused enhanced IL1beta secretion from PMA-treated cells. Nickel 34-40 interleukin 1 alpha Homo sapiens 81-88 29524267-0 2018 Cytokine patterns in vitro, in particular IL-5/IL-8 ratio, to detect patients with nickel contact allergy. Nickel 83-89 interleukin 5 Homo sapiens 42-46 29524267-0 2018 Cytokine patterns in vitro, in particular IL-5/IL-8 ratio, to detect patients with nickel contact allergy. Nickel 83-89 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 30014179-0 2018 Biomechanical properties of CAD/CAM-individualized nickel-titanium lingual retainers: an in vitro study. Nickel 51-57 calmodulin 3 Homo sapiens 32-35 30109310-3 2018 Herein, MMP-2-responsive nanoprobes were prepared by immobilizing fluorescent fusion proteins on nickel ferrite nanoparticles via the His-tag nickel chelation mechanism. Nickel 97-103 matrix metallopeptidase 2 Homo sapiens 8-13 30015946-3 2018 In our previous study, we identified a functional crosstalk between miR-152 and DNA methyltransferase 1 (DNMT1) involved in Nis-induced malignant transformation. Nickel 124-127 microRNA 152 Homo sapiens 68-75 30015946-3 2018 In our previous study, we identified a functional crosstalk between miR-152 and DNA methyltransferase 1 (DNMT1) involved in Nis-induced malignant transformation. Nickel 124-127 DNA methyltransferase 1 Homo sapiens 80-103 30015946-3 2018 In our previous study, we identified a functional crosstalk between miR-152 and DNA methyltransferase 1 (DNMT1) involved in Nis-induced malignant transformation. Nickel 124-127 DNA methyltransferase 1 Homo sapiens 105-110 30016632-0 2018 Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549 cells. Nickel 30-36 toll like receptor 4 Homo sapiens 89-93 30016632-0 2018 Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549 cells. Nickel 30-36 nuclear factor kappa B subunit 1 Homo sapiens 94-103 30356962-6 2018 Nickel-chelating liposomes efficiently incorporate twofold newly synthesized NHis-Cx43 compared with Cx43. Nickel 0-6 gap junction protein alpha 1 Homo sapiens 82-86 30105344-2 2018 Herein, two new kinds of Ni (POxN3-x)2/NPC and Co (POxN3-x)2/NPC (NPC: N, P-co-doped carbon) are synthesized through a facile post-treatment of nickel- or cobalt-phytic acid xerogel, followed by an annealing procedure under an argon and ammonia atmosphere at 800 C. The as-prepared catalysts exhibit outstanding catalytic activities for both the oxygen reduction and evolution reactions, which are comparable to those of Pt/C and IrO2. Nickel 144-150 NPC intracellular cholesterol transporter 1 Homo sapiens 29-49 30105344-2 2018 Herein, two new kinds of Ni (POxN3-x)2/NPC and Co (POxN3-x)2/NPC (NPC: N, P-co-doped carbon) are synthesized through a facile post-treatment of nickel- or cobalt-phytic acid xerogel, followed by an annealing procedure under an argon and ammonia atmosphere at 800 C. The as-prepared catalysts exhibit outstanding catalytic activities for both the oxygen reduction and evolution reactions, which are comparable to those of Pt/C and IrO2. Nickel 144-150 NPC intracellular cholesterol transporter 1 Homo sapiens 29-42 30138321-2 2018 Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta). Nickel 63-69 NLR family, pyrin domain containing 3 Mus musculus 92-97 30138321-2 2018 Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta). Nickel 63-69 caspase 1 Mus musculus 169-178 30138321-2 2018 Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta). Nickel 63-69 interleukin 1 beta Mus musculus 249-257 29784368-1 2018 An ultrasensitive electrochemiluminescence (ECL) immunosensor was initially developed for quantitative detection of carbohydrate antigen 15-3 (CA15-3) using platinum nickel nanocubes-L-cysteine-luminol nanocomposite (PtNi NCs-L-Cys-luminol) as signal probe. Nickel 166-172 mucin 1, cell surface associated Homo sapiens 116-149 30356966-3 2018 The Fe-CoP/NF (nickel foam) catalyst shows efficient electrocatalytic activity for oxygen evolution reaction, requiring low overpotentials of 190, 295, and 428 mV to achieve 10, 500, and 1000 mA cm-2 current densities in 1.0 m KOH solution. Nickel 15-21 caspase recruitment domain family member 16 Homo sapiens 7-10 29893037-3 2018 Copper and nickel foams have been employed as supports for the epitaxial growth of hcp-Co nanowires directly from a solution containing a coordination compound of cobalt and stabilizing ligands. Nickel 11-17 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 83-86 30109436-8 2018 RESULTS: Nickel-sensitive patients showed a statistical increase in CD4+ reactivity compared to CD8+ reactivity. Nickel 9-15 CD4 molecule Homo sapiens 68-71 30109436-9 2018 The ratio of CD4+/CD8+ T lymphocytes was 1.28 in nickel-sensitive patients versus 0.76 in the control (p = 0.009). Nickel 49-55 CD4 molecule Homo sapiens 13-16 30109436-9 2018 The ratio of CD4+/CD8+ T lymphocytes was 1.28 in nickel-sensitive patients versus 0.76 in the control (p = 0.009). Nickel 49-55 CD8a molecule Homo sapiens 18-21 29691693-7 2018 Analysis of the mRNA levels of genes related to thyroid development (hhex, nkx2.1, and pax8) and THs synthesis (nis and tg) revealed that exposure to higher Hg2+ concentrations markedly up-regulated hhex, nkx2.1, nis, and tg expression, while had no significant effect on the transcripts of pax8. Nickel 213-216 hematopoietically expressed homeobox Danio rerio 199-203 29614421-0 2018 Tuning the morphology and Fe/Ni ratio of a bimetallic Fe-Ni-S film supported on nickel foam for optimized electrolytic water splitting. Nickel 80-86 solute carrier family 5 member 5 Homo sapiens 57-61 29759035-3 2018 NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). Nickel 0-3 solute carrier family 5 member 5 Homo sapiens 19-25 30384873-2 2018 Methods According to the CypA gene sequence, the recombinant protein of CypA was expressed by the prokaryotic expression vector and purified by a nickel affinity chromatography column. Nickel 146-152 peptidylprolyl isomerase A Homo sapiens 72-76 29888442-3 2018 Herein, a metal-organic framework (MOF)-template strategy was developed to prepare non-noble metal co-catalyst/solid solution heterojunction NiS/Znx Cd1-x S with superior photocatalytic HER activity. Nickel 141-144 CD1c molecule Homo sapiens 149-152 31080304-4 2018 Complexes 1a,b also react with CO2 via MLC to form a rare example of eta1 binding of CO2 to nickel, complexes 4a,b. Nickel 92-98 secreted phosphoprotein 1 Homo sapiens 69-73 29943580-1 2018 Nickel-catalyzed arylcarboxylation of alkynes with arylmagnesium reagents and carbon dioxide (CO2, 1 atm) was realized in one pot. Nickel 0-6 complement C2 Homo sapiens 94-104 29863834-2 2018 In this work, a case study is carried out on nickel-based cation-disordered Fm3 m LiNi0.5M0.5O2 positive electrode materials. Nickel 45-51 neuromedin U receptor 1 Homo sapiens 76-79 29863834-5 2018 The direct synthesis of various new unknown ternary nickel-based Fm3 m cation-disordered rock-salt positive electrode materials is presented with a particular focus on the LiNi0.5V0.5O2 system. Nickel 52-58 neuromedin U receptor 1 Homo sapiens 65-68 29942950-2 2018 In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media. Nickel 71-77 caspase recruitment domain family member 16 Homo sapiens 47-50 29942950-2 2018 In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media. Nickel 71-77 caspase recruitment domain family member 16 Homo sapiens 91-94 29915845-1 2018 A highly efficient and simple route for the synthesis of multi-substituted allenes has been developed by a nickel catalyzed SN2" substitution reaction of propargyl esters with organic aluminium reagents under mild conditions, which gave the corresponding multi-substituted allenes in good to excellent yields (up to 92%) and high selectivities (up to 99%) at 60 C for 6 h in THF. Nickel 107-113 solute carrier family 38 member 5 Homo sapiens 124-127 29551716-4 2018 To overcome this, in this paper we present a protocol for the solubilisation of BTV VP7 from inclusion bodies expressed in E.coli, and subsequent purification using nickel affinity chromatography. Nickel 165-171 VP7 Bluetongue virus 84-87 29799717-2 2018 To address these issues, we report here nickel nanoparticles filled in vertically grown carbon nanotubes (CNTs) on graphene sheets (graphene-CNT-nickel composite (Gr-CNT-Ni)) that are coated onto a polypropylene separator as a polysulfide trap for the construction of high-loading sulfur cathodes. Nickel 40-46 TRAP Homo sapiens 239-243 29868660-1 2018 Herein, supported Ni/MCF-17 catalysts with the size of nickel nanocrystal in the range of 1.5-8.0 nm were synthesized and employed for COx-free hydrogen production for fuel cells via the ammonia decomposition reaction. Nickel 55-61 cytochrome c oxidase subunit 8A Homo sapiens 135-138 29977407-9 2018 Electrolysis of HMF using a CoB modified nickel foam electrode at 1.45 V vs RHE achieved close to 100% selective conversion of HMF to FDCA at 100% faradaic efficiency. Nickel 41-47 metabolism of cobalamin associated B Homo sapiens 28-31 29772533-1 2018 We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Nickel 78-81 solute carrier family 26 member 4 Homo sapiens 41-48 29772533-4 2018 Pendrin was more homologous to NIS (25%) than AIT (20%), particularly in the STAS domain (sulfate transporter and antisigma factor antagonist). Nickel 31-34 solute carrier family 26 member 4 Homo sapiens 0-7 29772533-7 2018 Pendrin residues which are mutated in Pendred"s syndrome are identical to those in the aligned position of NIS and AIT. Nickel 107-110 solute carrier family 26 member 4 Homo sapiens 0-7 29528143-0 2018 Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1. Nickel 0-6 zinc finger E-box binding homeobox 1 Homo sapiens 121-125 29620212-0 2018 LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Nickel 45-48 La ribonucleoprotein 7, transcriptional regulator Homo sapiens 0-5 29620212-0 2018 LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Nickel 45-48 sonic hedgehog signaling molecule Homo sapiens 87-90 29620212-10 2018 However, treatment with recombinant human SHH partially reduced radioiodine uptake ability and NIS expression induced by LARP7. Nickel 95-98 sonic hedgehog signaling molecule Homo sapiens 42-45 29620212-10 2018 However, treatment with recombinant human SHH partially reduced radioiodine uptake ability and NIS expression induced by LARP7. Nickel 95-98 La ribonucleoprotein 7, transcriptional regulator Homo sapiens 121-126 29787284-0 2018 Selective Synthesis of Aryl Nitriles and 3-Imino-1-oxoisoindolines via Nickel-Promoted C(sp2)-H Cyanations. Nickel 71-77 Sp2 transcription factor Homo sapiens 87-92 29513268-3 2018 With this perspective, MOF derived hollow cubes of nickel cobalt ferrites have been synthesized via a facile process using sacrificial templates at 600 C. Microcubes, composed of tiny grains in a size range from 10 nm +- 2 nm were obtained in pure form as a polycrystalline material. Nickel 51-57 lysine acetyltransferase 8 Homo sapiens 23-26 30023906-1 2018 The nickel PNP pincer complex ( i PrPNP)NiPh ( i PrPNP = kappaP,kappaN,kappaP-N(CH2CH2P i Pr2)2) was prepared by reacting ( i PrPNP)NiBr with PhMgCl or deprotonating [( i PrPNHP)NiPh]Y ( i PrPNHP = kappaP,kappaN,kappaP-HN(CH2CH2P i Pr2)2; Y = Br, PF6) with KO t Bu. Nickel 4-10 sperm associated antigen 17 Homo sapiens 247-250 29745942-5 2018 The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively. Nickel 232-238 cystathionine beta-synthase Homo sapiens 120-123 29762528-3 2018 Here, we report improved activated carbon (AC) electrodes (AC@G@NiF/G) simultaneously combining chemical vapor deposition (CVD) graphene-modified nickel foams (NiF/Gs) current collectors and high quality few-layer graphene conductive additive instead of carbon black (CB). Nickel 146-152 S100 calcium binding protein A9 Homo sapiens 64-67 29746104-1 2018 Nickel (Ni), cobalt (Co), and zinc (Zn) loaded on fibrous silica KCC-1 was investigated for CO2 methanation reactions. Nickel 0-6 solute carrier family 12 member 4 Homo sapiens 65-70 29676412-2 2018 In this Communication, we report a space-confined phosphidation strategy toward developing hierarchical CoP nanosheet@microwire arrays on nickel foam (CoP NS@MW/NF) using a Co(H2PO4)2 2H3PO4 microwire array as the precursor. Nickel 138-144 caspase recruitment domain family member 16 Homo sapiens 104-107 29676412-2 2018 In this Communication, we report a space-confined phosphidation strategy toward developing hierarchical CoP nanosheet@microwire arrays on nickel foam (CoP NS@MW/NF) using a Co(H2PO4)2 2H3PO4 microwire array as the precursor. Nickel 138-144 caspase recruitment domain family member 16 Homo sapiens 151-154 29408101-1 2018 The SnS2 nanoflowers anchored on three dimensional porous graphene were easily constructed with nickel foam (NF) as supported backbone through the dip-coating method followed by one-step controllable hydrothermal growth and mild reduction. Nickel 96-102 sodium voltage-gated channel alpha subunit 11 Homo sapiens 4-8 29634236-7 2018 Two isolated nickel-CO2 adducts, (PPMeP)Ni(eta2-CO2-kappa C) (2) and {Na(12-C-4)2}{(PNP)Ni(eta1-CO2-kappa C)} (7), clearly demonstrate that the geometry of the nickel ion is crucial in the binding of CO2 and its level of activation. Nickel 13-19 DNA polymerase iota Homo sapiens 43-47 29634236-7 2018 Two isolated nickel-CO2 adducts, (PPMeP)Ni(eta2-CO2-kappa C) (2) and {Na(12-C-4)2}{(PNP)Ni(eta1-CO2-kappa C)} (7), clearly demonstrate that the geometry of the nickel ion is crucial in the binding of CO2 and its level of activation. Nickel 13-19 secreted phosphoprotein 1 Homo sapiens 91-95 29601188-1 2018 The use of (L)Ni( o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos) enables the C( sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcohols with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. Nickel 242-248 regulator of calcineurin 2 Homo sapiens 89-98 29601188-2 2018 In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C( sp2)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods. Nickel 194-200 regulator of calcineurin 2 Homo sapiens 211-220 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 24-30 transformation related protein 53, pseudogene Mus musculus 90-93 29641477-1 2018 The hydrothermal method was used to dope different amounts of Co2+, Mn2+, and Cu2+ in nano-nickel zinc ferrite powder. Nickel 91-97 complement C2 Homo sapiens 62-65 29353191-6 2018 pH has little effect on the maximum adsorption capacity in the pH range of 2-10, while the presence of nickel reduces the capacity with Ni concentrations of 2.5-25 mg L-1. Nickel 103-109 immunoglobulin kappa variable 1-16 Homo sapiens 167-170 29517777-0 2018 Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation. Nickel 178-184 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-34 29517777-0 2018 Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation. Nickel 178-184 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-42 29517777-0 2018 Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation. Nickel 178-184 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-42 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 24-30 B cell leukemia/lymphoma 2 Mus musculus 125-130 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 24-30 B cell leukemia/lymphoma 2 Mus musculus 204-209 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 24-30 transformation related protein 53, pseudogene Mus musculus 391-394 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 277-283 B cell leukemia/lymphoma 2 Mus musculus 204-209 29996213-7 2018 The results showed that nickel refining dust induced cell damage through up-regulation of p53 protein and down-regulation of Bcl-2 protein expression; ascorbic acid interventions, the expression level of Bcl-2 protein in ascorbic acid II and III groups was higher than that of nickel refining dust group, and the difference was statistically significant (P<0.05); The expression level of p53 protein in each dose group of ascorbic acid was lower than that of nickel refined dust group, and the difference was statistically significant (P<0.05). Nickel 277-283 B cell leukemia/lymphoma 2 Mus musculus 204-209 29400057-0 2018 Dual-Functional Starfish-like P-Doped Co-Ni-S Nanosheets Supported on Nickel Foams with Enhanced Electrochemical Performance and Excellent Stability for Overall Water Splitting. Nickel 70-76 solute carrier family 5 member 5 Homo sapiens 41-45 29996213-0 2018 [Effects of ascorbic acid on the expression of p53 and Bcl-2 protein in NIH/3T3 cells exposed to nickel]. Nickel 97-103 transformation related protein 53, pseudogene Mus musculus 47-50 29996213-0 2018 [Effects of ascorbic acid on the expression of p53 and Bcl-2 protein in NIH/3T3 cells exposed to nickel]. Nickel 97-103 B cell leukemia/lymphoma 2 Mus musculus 55-60 29461813-0 2018 Ligand-Controlled Chemoselective C(acyl)-O Bond vs C(aryl)-C Bond Activation of Aromatic Esters in Nickel Catalyzed C(sp2)-C(sp3) Cross-Couplings. Nickel 99-105 Sp2 transcription factor Homo sapiens 116-121 29305420-8 2018 Mfrn1 can also transport manganese, cobalt, copper, and zinc but discriminates against nickel. Nickel 87-93 solute carrier family 25 member 37 Homo sapiens 0-5 29502734-1 2018 Nickel-chromium(Ni-Cr) based alloys account for the majority of the porcelain-fused-to-metal fixed dental prostheses(PFM-FDPs) on account of their superior properties despite both nickel and chromium being known as human carcinogens. Nickel 0-6 farnesyl diphosphate synthase Homo sapiens 121-125 29400057-2 2018 Herein, for the first time, a shape-controlled synthesis of starfish-like Co-Ni-S nanosheets on three-dimensional (3D) hierarchically porous nickel foams (Co-Ni-S/NF) via a one-step hydrothermal method was developed. Nickel 141-147 solute carrier family 5 member 5 Homo sapiens 77-81 29400057-2 2018 Herein, for the first time, a shape-controlled synthesis of starfish-like Co-Ni-S nanosheets on three-dimensional (3D) hierarchically porous nickel foams (Co-Ni-S/NF) via a one-step hydrothermal method was developed. Nickel 141-147 solute carrier family 5 member 5 Homo sapiens 158-162 29495389-2 2018 In this study, we analyzed the impact of miR-146a on the expression and function of NIS and on the overall survival of thyroid cancer patients. Nickel 84-87 microRNA 146a Homo sapiens 41-49 29495389-7 2018 In the results, we showed that miR-146a-3p directly binds to and inhibits NIS. Nickel 74-77 microRNA 146a Homo sapiens 31-39 29495389-8 2018 Inhibition of miR-146a-3p restores the expression and function of NIS, increasing radioactive iodine uptake. Nickel 66-69 microRNA 146a Homo sapiens 14-22 29355601-0 2018 Nickel ions bind to HSP90beta and enhance HIF-1alpha-mediated IL-8 expression. Nickel 0-6 heat shock protein 90 alpha family class B member 1 Homo sapiens 20-29 29355601-0 2018 Nickel ions bind to HSP90beta and enhance HIF-1alpha-mediated IL-8 expression. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 42-52 29355601-0 2018 Nickel ions bind to HSP90beta and enhance HIF-1alpha-mediated IL-8 expression. Nickel 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 29443956-0 2018 Gold and Nickel Extended Thiophenic-TTF Bisdithiolene Complexes. Nickel 9-15 ras homolog family member H Homo sapiens 36-39 29343060-7 2018 Upon addition of CO2 to a nickel(0)-CO species, a nickel(II) carboxylate species with a Ni(eta1-CO2-kappaC) moiety was formed and isolated (75%). Nickel 26-32 secreted phosphoprotein 1 Homo sapiens 91-95 30956387-1 2018 Modelling of crack tip behaviour was carried out for a nickel-based superalloy subjected to high temperature fatigue in a vacuum and air. Nickel 55-61 TOR signaling pathway regulator Homo sapiens 19-22 29178431-3 2018 Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50 C. Nickel 59-65 mitochondrially encoded cytochrome c oxidase II Homo sapiens 244-248 27258560-1 2018 BACKGROUND: Intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses is an uncommon tumor associated with exposure to wood and leather dust, nickel, and possibly smoking. Nickel 164-170 C-X-C motif chemokine ligand 11 Homo sapiens 12-49 29193522-1 2018 An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp3 -carbon fragments. Nickel 194-200 Sp3 transcription factor Homo sapiens 241-244 29152826-0 2018 Synthesis and Reactivity of Nickel-Stabilised mu2 :eta2 ,eta2 -P2 , As2 and PAs Units. Nickel 28-34 adaptor related protein complex 1 subunit mu 2 Homo sapiens 46-49 29152826-0 2018 Synthesis and Reactivity of Nickel-Stabilised mu2 :eta2 ,eta2 -P2 , As2 and PAs Units. Nickel 28-34 DNA polymerase iota Homo sapiens 51-55 29152826-0 2018 Synthesis and Reactivity of Nickel-Stabilised mu2 :eta2 ,eta2 -P2 , As2 and PAs Units. Nickel 28-34 DNA polymerase iota Homo sapiens 57-61 29124840-4 2018 Electrochemical measurements indicated a stronger electronic coupling between Hb and Cyt C oxidase and the mixed-SAM-coated gold or gold-coated-nickel electrodes, whereas a weaker coupling was found between the protein and the pure nickel electrode. Nickel 144-150 cytochrome c, somatic Homo sapiens 85-90 29301501-6 2018 His/NEDD8-conjugated proteins were pulled down with nickel-affinity beads under a denaturing condition, and identified by Western blotting. Nickel 52-58 NEDD8 ubiquitin like modifier Homo sapiens 4-9 29024095-3 2018 In our approach, nickel is readily coordinated to a Schiff base cavity, and then a range of redox-inactive cations (M=Na+ , Ca2+ , Nd3+ , and Y3+ ) are installed in a pendant crown-ether-like site. Nickel 17-23 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 131-134 29850654-4 2018 The recombinant soluble hSOD1 was expressed in E. coli BL21 (DE3) at 37 C and purified using nickel column affinity chromatography. Nickel 93-99 superoxide dismutase 1 Homo sapiens 24-29 29526911-3 2018 The calculated detection limits were 0.25 mug L-1 for strontium and 3.56 mug L-1 for nickel. Nickel 85-91 immunoglobulin kappa variable 1-16 Homo sapiens 77-80 28885308-0 2018 Military Decorative Pin Dermatitis: Prevention for Nickel Allergy Among Service Members. Nickel 51-57 dynein light chain LC8-type 1 Homo sapiens 20-23 30509471-1 2018 The chapter focuses on the methods involved in producing and characterizing two key nickel-iron-sulfur enzymes in the Wood-Ljungdahl pathway (WLP) of anaerobic conversion of carbon dioxide fixation into acetyl-CoA: carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS). Nickel 84-90 acyl-CoA synthetase short chain family member 2 Homo sapiens 256-275 30210089-7 2018 CONCLUSION: Nickel has caused augmentation of PE-induced contractions as a result of the endothelial generation of reactive oxygen species (ROS) and cyclooxygenase 2 (COX2) dependent endothelium contracting factors (EDCFs), which increases the influx of extracellular calcium through T-type Ca2+ channels in smooth muscle cells. Nickel 12-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 149-165 30210089-7 2018 CONCLUSION: Nickel has caused augmentation of PE-induced contractions as a result of the endothelial generation of reactive oxygen species (ROS) and cyclooxygenase 2 (COX2) dependent endothelium contracting factors (EDCFs), which increases the influx of extracellular calcium through T-type Ca2+ channels in smooth muscle cells. Nickel 12-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 167-171 30509471-1 2018 The chapter focuses on the methods involved in producing and characterizing two key nickel-iron-sulfur enzymes in the Wood-Ljungdahl pathway (WLP) of anaerobic conversion of carbon dioxide fixation into acetyl-CoA: carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS). Nickel 84-90 acyl-CoA synthetase short chain family member 2 Homo sapiens 277-280 29132256-0 2018 MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. Nickel 95-101 C-C motif chemokine ligand 2 Homo sapiens 0-5 29132256-1 2018 To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Nickel 107-113 C-C motif chemokine ligand 2 Homo sapiens 41-75 29132256-1 2018 To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Nickel 107-113 C-C motif chemokine ligand 2 Homo sapiens 77-82 29132256-3 2018 The expressions of MCP-1 in HaCaT cell culture after nickel treatment were quantified by enzyme-linked immunosorbent assay. Nickel 53-59 chemokine (C-C motif) ligand 2 Mus musculus 19-24 29132256-4 2018 The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24-48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. Nickel 36-42 C-C motif chemokine ligand 2 Homo sapiens 83-88 29132256-4 2018 The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24-48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. Nickel 36-42 CD68 molecule Homo sapiens 262-266 29132256-4 2018 The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24-48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. Nickel 208-214 C-C motif chemokine ligand 2 Homo sapiens 83-88 29132256-5 2018 The expressions of MCP-1 declined gradually in the late phase (72-96 h after nickel application). Nickel 77-83 C-C motif chemokine ligand 2 Homo sapiens 19-24 29132256-7 2018 The data indicated that a temporal expression pattern of MCP-1 produced by keratinocytes after nickel exposure was involved in the complex process of mononuclear cell infiltration during elicitation of nickel-induced OACD. Nickel 95-101 C-C motif chemokine ligand 2 Homo sapiens 57-62 29132256-7 2018 The data indicated that a temporal expression pattern of MCP-1 produced by keratinocytes after nickel exposure was involved in the complex process of mononuclear cell infiltration during elicitation of nickel-induced OACD. Nickel 202-208 C-C motif chemokine ligand 2 Homo sapiens 57-62 28062193-0 2017 Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)C(sp3) cross-coupling. Nickel 90-96 Sp3 transcription factor Homo sapiens 119-130 29131623-2 2017 Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide entry into the thyroid. Nickel 119-122 solute carrier family 5 member 8 Homo sapiens 67-72 28062193-1 2017 We report herein the transfer of dual photoredox and nickel catalysis for C(sp2)C(sp3) cross coupling form batch to flow. Nickel 53-59 Sp3 transcription factor Homo sapiens 74-85 28396984-0 2017 Iodinated TG in Thyroid Follicles Regulate TSH/TSHR Signaling for NIS Expression. Nickel 66-69 thyroid stimulating hormone receptor Homo sapiens 47-51 28675793-4 2017 Nickel caused an increase in renal levels of malondialdehyde and a decrease in reduced glutathione, catalase, and superoxide dismutase levels and total antioxidant capacity. Nickel 0-6 catalase Rattus norvegicus 100-108 28675793-8 2017 Carnosine corrected the biochemical abnormalities and the elevated renal TNF-alpha and IL-6 levels in the nickel-treated group. Nickel 106-112 tumor necrosis factor Rattus norvegicus 73-82 28675793-8 2017 Carnosine corrected the biochemical abnormalities and the elevated renal TNF-alpha and IL-6 levels in the nickel-treated group. Nickel 106-112 interleukin 6 Rattus norvegicus 87-91 28916473-10 2017 We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA). Nickel 122-125 cytochrome b-245 beta chain Homo sapiens 129-133 28916473-10 2017 We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA). Nickel 122-125 cytochrome b-245 beta chain Homo sapiens 135-139 28916473-10 2017 We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA). Nickel 122-125 mitochondrially encoded cytochrome b Homo sapiens 177-189 30053080-10 2017 Expression of PIGU in the K1 human papillary carcinoma cell line resulted in a robust increase in NIS glycosylation and trafficking to the cell membrane, accompanied by a robust increase in I125 uptake both in vitro (465 200 +- 56 343 vs 1236 +- 156 counts per million, P < .001) and in vivo (128 945 +- 28 556 vs 7963 +- 192 counts per million, P < .001, n = 5 mice per group). Nickel 98-101 phosphatidylinositol glycan anchor biosynthesis class U Homo sapiens 14-18 30053080-13 2017 Conclusions: We showed that downregulation of PIGU in DTC determines NIS function and RAI avidity. Nickel 69-72 phosphatidylinositol glycan anchor biosynthesis class U Homo sapiens 46-50 29099520-1 2017 Reacting the low-valent nickel complex [(dtbpe)Ni]2(mu-eta2:eta2-C6H6) with oxaziridines was found to form mixtures of imine, amide and aldehyde products. Nickel 24-30 DNA polymerase iota Homo sapiens 55-59 29210991-3 2017 Benefiting from the collaborative advantages of Ni(P, O)x and amorphous MoOx, as well as three-dimensional porous conductive nickel scaffold, the hybrid electrocatalyst shows high catalytic activity in 1 M KOH aqueous solution, including a small overpotential of 59 mV at 10 mA cm-2, a low Tafel slope of 54 mV dec-1, and excellent cycling stability. Nickel 125-131 deleted in esophageal cancer 1 Homo sapiens 311-316 29058417-0 2017 Cell-Permeable, MMP-2 Activatable, Nickel Ferrite and His-Tagged Fusion Protein Self-Assembled Fluorescent Nanoprobe for Tumor Magnetic-Targeting and Imaging. Nickel 35-41 matrix metallopeptidase 2 Homo sapiens 16-21 29086786-4 2017 Here we find that as the duration of the post-synthesis thermal treatment (at 500 C) of LiNi1/3Co1/3Mn1/3O2 (NCM) was increased, the Li/Ni molar ratio in the final product was found to decrease, and this was attributed to the reduction in nickel occupying lithium sites; the cation mixing subtly changed; and those subtle variations remarkably influence their cycling performance. Nickel 240-246 CWC22 spliceosome associated protein homolog Homo sapiens 110-113 29127306-4 2017 Nickel increased miR-4417 expression and decreased its target gene TAB2 expression. Nickel 0-6 microRNA 4417 Homo sapiens 17-25 29127306-10 2017 Induction of abundant miR-4417 and reduction of TAB2 expression following nickel exposure and may be involved in nickel-induced fibronectin. Nickel 74-80 microRNA 4417 Homo sapiens 22-30 29127306-10 2017 Induction of abundant miR-4417 and reduction of TAB2 expression following nickel exposure and may be involved in nickel-induced fibronectin. Nickel 74-80 fibronectin 1 Homo sapiens 128-139 29127306-10 2017 Induction of abundant miR-4417 and reduction of TAB2 expression following nickel exposure and may be involved in nickel-induced fibronectin. Nickel 113-119 microRNA 4417 Homo sapiens 22-30 29127306-10 2017 Induction of abundant miR-4417 and reduction of TAB2 expression following nickel exposure and may be involved in nickel-induced fibronectin. Nickel 113-119 fibronectin 1 Homo sapiens 128-139 29072761-2 2017 In this communication, we describe the development of a Co-carbonate-hydroxide nanowire array on nickel foam (CoCH/NF) via in situ electrochemical conversion of the Co(CO3)0.5(OH) 0.11H2O nanowire array. Nickel 97-103 cochlin Homo sapiens 110-114 29020768-1 2017 Photocatalytic upgrading of crucial biomass-derived intermediate chemicals (i.e., furfural alcohol, 5-hydroxymethylfurfural (HMF)) to value-added products (aldehydes and acids) was carried out on ultrathin CdS nanosheets (thickness ~1 nm) decorated with nickel (Ni/CdS). Nickel 254-260 CDP-diacylglycerol synthase 1 Homo sapiens 206-209 29285270-0 2017 Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Nickel 21-27 hexokinase 2 Homo sapiens 78-90 29285270-0 2017 Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Nickel 21-27 lipocalin 2 Homo sapiens 103-114 29285270-4 2017 In this study, we determined that hexokinase 2 (HK2), which phosphorylates glucose and regulates autophagy, is the key mediator in nickel-induced autophagy in lung bronchial epithelial cells. Nickel 131-137 hexokinase 2 Homo sapiens 34-46 29285270-4 2017 In this study, we determined that hexokinase 2 (HK2), which phosphorylates glucose and regulates autophagy, is the key mediator in nickel-induced autophagy in lung bronchial epithelial cells. Nickel 131-137 hexokinase 2 Homo sapiens 48-51 29285270-6 2017 Our results showed that metformin decreases nickel-induced autophagy and activation of apoptosis through inhibition of HK2 gene, protein and activity. Nickel 44-50 hexokinase 2 Homo sapiens 119-122 29285270-8 2017 Knockdown of endogenous HK2 and LCN2 by shRNA reduced nickel-elicited autophagy and apoptosis, illustrating that metabolic alteration and inflammatory action are important in nickel-elicited carcinogenesis. Nickel 54-60 hexokinase 2 Homo sapiens 24-27 29285270-8 2017 Knockdown of endogenous HK2 and LCN2 by shRNA reduced nickel-elicited autophagy and apoptosis, illustrating that metabolic alteration and inflammatory action are important in nickel-elicited carcinogenesis. Nickel 54-60 lipocalin 2 Homo sapiens 32-36 29285270-8 2017 Knockdown of endogenous HK2 and LCN2 by shRNA reduced nickel-elicited autophagy and apoptosis, illustrating that metabolic alteration and inflammatory action are important in nickel-elicited carcinogenesis. Nickel 175-181 hexokinase 2 Homo sapiens 24-27 29285270-8 2017 Knockdown of endogenous HK2 and LCN2 by shRNA reduced nickel-elicited autophagy and apoptosis, illustrating that metabolic alteration and inflammatory action are important in nickel-elicited carcinogenesis. Nickel 175-181 lipocalin 2 Homo sapiens 32-36 29285270-10 2017 Inhibition of nickel-induced autophagy abolished apoptotic cell death in chloroquine-treated, shLC3 Beas-2B cells and Atg5-/- MFFs. Nickel 14-20 autophagy related 5 Homo sapiens 118-122 28190186-10 2017 Our data implied that low iodine in the follicular lumen caused by cytoplasm mis-localization of NIS may induce nodular goiter. Nickel 97-100 anti-Mullerian hormone Homo sapiens 77-80 29099520-1 2017 Reacting the low-valent nickel complex [(dtbpe)Ni]2(mu-eta2:eta2-C6H6) with oxaziridines was found to form mixtures of imine, amide and aldehyde products. Nickel 24-30 DNA polymerase iota Homo sapiens 60-64 29099520-5 2017 Preliminary mechanistic analysis is consistent with a bimetallic mechanism of fragmentation of the oxazanickelacyclobutane to form the nickel imido and eta2-aldehyde complexes. Nickel 104-110 DNA polymerase iota Homo sapiens 152-156 28956039-0 2017 A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation. Nickel 74-80 solute carrier family 38 member 5 Homo sapiens 22-25 28956039-1 2017 In this study, three reaction mechanisms of a benzyne-nickel (Ni) complex ([Ni(C6H4)(dcpe)]) with iodomethane during the methylation process were investigated, namely (a) SN2 reaction of the benzyne-Ni complex with iodomethane, (b) concerted sigma-bond metathesis during the bond breaking/forming processes, and (c) oxidative addition of iodomethane to the Ni-center and the subsequent reductive elimination process. Nickel 54-60 solute carrier family 38 member 5 Homo sapiens 171-174 29190908-6 2017 Mice that were injected with LPEI-PEG-GE11/NIS 48 h before 18F-TFB application showed high tumoral levels (4.8+-0.6% of injected dose) of NIS-mediated radionuclide uptake in comparison to low levels detected in mice that received untargeted control polyplexes. Nickel 43-46 progestagen associated endometrial protein Homo sapiens 34-37 28191674-2 2017 We have reported that the expression of histidine decarboxylase (HDC) was induced by subcutaneous implantation of nickel (Ni) wire. Nickel 114-120 histidine decarboxylase Mus musculus 40-63 28191674-2 2017 We have reported that the expression of histidine decarboxylase (HDC) was induced by subcutaneous implantation of nickel (Ni) wire. Nickel 114-120 histidine decarboxylase Mus musculus 65-68 28634033-3 2017 Whereas IL-12p70 promotes T helper (Th) 1 cell polarization, IL-23 promotes Th17 cell development and both have been isolated from nickel-allergic patients. Nickel 131-137 interleukin 23 subunit alpha Homo sapiens 61-66 28634033-5 2017 We showed that nickel induced an early production of IL-23 in human monocyte-derived dendritic cells along with an increase in the expression of il-23p19 and il-12p40 mRNA. Nickel 15-21 interleukin 23 subunit alpha Homo sapiens 53-58 28634033-5 2017 We showed that nickel induced an early production of IL-23 in human monocyte-derived dendritic cells along with an increase in the expression of il-23p19 and il-12p40 mRNA. Nickel 15-21 interleukin 23 subunit alpha Homo sapiens 145-153 28634033-7 2017 Moreover, nickel-treated monocyte-derived dendritic cells induced an increase in the percentage of IL-17A+ CD4+ T cells, an effect reduced by IL-23 neutralization. Nickel 10-16 interleukin 17A Homo sapiens 99-105 28634033-7 2017 Moreover, nickel-treated monocyte-derived dendritic cells induced an increase in the percentage of IL-17A+ CD4+ T cells, an effect reduced by IL-23 neutralization. Nickel 10-16 interleukin 23 subunit alpha Homo sapiens 142-147 28634033-9 2017 Our results showed that toll-like receptor 4, p38 mitogen-activated protein kinase, and NF-kappaB were involved in IL-23 production induced by nickel. Nickel 143-149 toll like receptor 4 Homo sapiens 24-44 28634033-9 2017 Our results showed that toll-like receptor 4, p38 mitogen-activated protein kinase, and NF-kappaB were involved in IL-23 production induced by nickel. Nickel 143-149 mitogen-activated protein kinase 14 Homo sapiens 46-49 28634033-9 2017 Our results showed that toll-like receptor 4, p38 mitogen-activated protein kinase, and NF-kappaB were involved in IL-23 production induced by nickel. Nickel 143-149 interleukin 23 subunit alpha Homo sapiens 115-120 28634033-11 2017 These results indicate that nickel-induced Th17 cell development is dependent on the production of IL-23 by human monocyte-derived dendritic cells via toll-like receptor 4, p38 mitogen-activated protein kinase, NF-kappaB, and Jak-signal transducer and activator of transcription pathways. Nickel 28-34 interleukin 23 subunit alpha Homo sapiens 99-104 28634033-11 2017 These results indicate that nickel-induced Th17 cell development is dependent on the production of IL-23 by human monocyte-derived dendritic cells via toll-like receptor 4, p38 mitogen-activated protein kinase, NF-kappaB, and Jak-signal transducer and activator of transcription pathways. Nickel 28-34 toll like receptor 4 Homo sapiens 151-171 28634033-11 2017 These results indicate that nickel-induced Th17 cell development is dependent on the production of IL-23 by human monocyte-derived dendritic cells via toll-like receptor 4, p38 mitogen-activated protein kinase, NF-kappaB, and Jak-signal transducer and activator of transcription pathways. Nickel 28-34 mitogen-activated protein kinase 14 Homo sapiens 173-176 29190908-6 2017 Mice that were injected with LPEI-PEG-GE11/NIS 48 h before 18F-TFB application showed high tumoral levels (4.8+-0.6% of injected dose) of NIS-mediated radionuclide uptake in comparison to low levels detected in mice that received untargeted control polyplexes. Nickel 138-141 progestagen associated endometrial protein Homo sapiens 34-37 29190908-8 2017 In conclusion, these preclinical data confirm the enormous potential of EGFR-targeted synthetic polymers for systemic NIS gene delivery in an advanced multifocal CRC liver metastases model and open the exciting prospect of NIS-mediated radionuclide therapy in metastatic disease. Nickel 118-121 epidermal growth factor receptor Homo sapiens 72-76 29190908-8 2017 In conclusion, these preclinical data confirm the enormous potential of EGFR-targeted synthetic polymers for systemic NIS gene delivery in an advanced multifocal CRC liver metastases model and open the exciting prospect of NIS-mediated radionuclide therapy in metastatic disease. Nickel 223-226 epidermal growth factor receptor Homo sapiens 72-76 28552779-1 2017 Nickel is a human carcinogen that acts as a hypoxia mimic by activating the transcription factor HIF-1alpha and hypoxia-like transcriptomic responses. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 97-107 28792729-2 2017 This nanocomposite catalyst consists of the CdS quantum dots (QDs) decorated Ni3S2 nanosheet flowers deposited on the plasma-treated nickel foam (PNF). Nickel 133-139 CDP-diacylglycerol synthase 1 Homo sapiens 44-47 28675702-8 2017 In the nickel/ICy-catalyzed reactions, the oxidative addition of the C(aryl)-OMe bond can proceed more easily without the aid of CsF because the nickel-ligand bonds are stronger and therefore stabilize the transition state. Nickel 7-13 colony stimulating factor 2 Homo sapiens 129-132 29104460-7 2017 Over expressed recombination NS1 (rNS1) fusion protein was purified by nickel affinity chromatography. Nickel 71-77 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 29-32 28675702-2 2017 In 2008, we have reported nickel/PCy3-catalyzed cross-coupling of methoxyarenes with arylboronic esters in which the addition of a stoichiometric base such as CsF is essential for the reaction to proceed. Nickel 26-32 colony stimulating factor 2 Homo sapiens 159-162 28528452-4 2017 The relation of NIS and p53 in clinical samples was judged by TCGA data analysis and immunohistochemistry. Nickel 16-19 tumor protein p53 Homo sapiens 24-27 28528452-5 2017 RESULTS: Overexpression of wild-type p53 as a transgene or pharmacological activation by doxorubicin drug treatment shows significant suppression of NIS transcription in multiple BC cell types which also results in lowered NIS protein content and cellular iodide intake. Nickel 149-152 tumor protein p53 Homo sapiens 37-40 28528452-5 2017 RESULTS: Overexpression of wild-type p53 as a transgene or pharmacological activation by doxorubicin drug treatment shows significant suppression of NIS transcription in multiple BC cell types which also results in lowered NIS protein content and cellular iodide intake. Nickel 223-226 tumor protein p53 Homo sapiens 37-40 28528452-6 2017 NIS repression by activated p53 is further confirmed by non-invasive bioluminescence imaging in live cell and orthotropic tumor model. Nickel 0-3 tumor protein p53 Homo sapiens 28-31 28528452-10 2017 CONCLUSION: Our data for the first time highlight the role of p53 as a negative regulator of functional NIS expression in BC, where the latter is a potential targeted radioiodine therapy candidate. Nickel 104-107 tumor protein p53 Homo sapiens 62-65 28319310-0 2017 CXCL4 is a novel nickel-binding protein and augments nickel allergy. Nickel 17-23 platelet factor 4 Mus musculus 0-5 28319310-0 2017 CXCL4 is a novel nickel-binding protein and augments nickel allergy. Nickel 53-59 platelet factor 4 Mus musculus 0-5 28319310-1 2017 BACKGROUND: Nickel (Ni) is the most frequent metal allergen and induces a TH1 -dependent type-IV allergy. Nickel 12-18 negative elongation factor complex member C/D, Th1l Mus musculus 74-77 28816195-0 2017 Pentraxin-3 Levels in Gingival Crevicular Fluid during Canine Retraction with Nickel-Titanium Coil Spring and Active Tieback. Nickel 78-84 pentraxin 3 Canis lupus familiaris 0-11 28675928-1 2017 The acetyl coenzyme A synthase (ACS) enzyme plays a central role in the metabolism of anaerobic bacteria and archaea, catalyzing the reversible synthesis of acetyl-CoA from CO and a methyl group through a series of nickel-based organometallic intermediates. Nickel 215-221 acyl-CoA synthetase short chain family member 2 Homo sapiens 4-30 28675928-1 2017 The acetyl coenzyme A synthase (ACS) enzyme plays a central role in the metabolism of anaerobic bacteria and archaea, catalyzing the reversible synthesis of acetyl-CoA from CO and a methyl group through a series of nickel-based organometallic intermediates. Nickel 215-221 acyl-CoA synthetase short chain family member 2 Homo sapiens 32-35 28675928-3 2017 In this work, we have developed a protein-based model for the NiP center of acetyl coenzyme A synthase using a nickel-substituted azurin protein (NiAz). Nickel 111-117 acyl-CoA synthetase short chain family member 2 Homo sapiens 76-102 28675928-4 2017 NiAz is the first model nickel protein system capable of accessing three (NiI/NiII/NiIII) distinct oxidation states within a physiological potential range in aqueous solution, a critical feature for achieving organometallic ACS activity, and binds CO and -CH3 groups with biologically relevant affinity. Nickel 24-30 acyl-CoA synthetase short chain family member 2 Homo sapiens 224-227 28947985-6 2017 The PD patients with high urinary nickel concentrations demonstrated higher log serum levels of high sensitivity C-reactive protein (0.4+-0.5 versus 0.1+-0.5 mg/L, P=0.046) than patients with normal urinary nickel concentrations. Nickel 34-40 C-reactive protein Homo sapiens 113-131 28592540-2 2017 Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids integrated into the lipid bilayer. Nickel 113-119 neurofilament light chain Homo sapiens 57-60 28592540-7 2017 Following immunization of mice, serologic analysis demonstrated that the covalently coupled trimers elicited Env-directed antibodies in a manner statistically significantly improved compared to soluble trimers and nickel-conjugated trimers. Nickel 214-220 melanoma antigen Mus musculus 109-112 28592540-12 2017 Our first-generation nickel-based liposomes captured HIV-1 Env glycoprotein trimers via a noncovalent linkage with improved efficacy over soluble glycoprotein in activating germinal center B cells and eliciting tier-2 autologous neutralizing antibodies. Nickel 21-27 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 59-62 28704055-0 2017 Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides. Nickel 16-22 Sp2 transcription factor Homo sapiens 37-40 28704055-0 2017 Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides. Nickel 16-22 Sp3 transcription factor Homo sapiens 41-44 28704055-1 2017 A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. Nickel 65-71 Sp2 transcription factor Homo sapiens 85-88 28704055-1 2017 A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. Nickel 65-71 Sp3 transcription factor Homo sapiens 89-92 28698652-7 2017 We also predict an achievable contact resistance of 30 Omega mum for nickel electrodes, extremely promising for applications. Nickel 69-75 latexin Homo sapiens 61-64 28515325-0 2017 Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel. Nickel 157-163 polo like kinase 3 Homo sapiens 26-44 28515325-0 2017 Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel. Nickel 157-163 siah E3 ubiquitin protein ligase 2 Homo sapiens 49-54 28515325-4 2017 Despite previous research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not completely understood. Nickel 98-104 polo like kinase 3 Homo sapiens 47-51 28515325-11 2017 We propose that suppression of Plk3 expression contributes to carcinogenesis and tumor progression induced by nickel compounds. Nickel 110-116 polo like kinase 3 Homo sapiens 31-35 28263966-0 2017 LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1alpha translation. Nickel 61-67 maternally expressed 3 Homo sapiens 7-11 28263966-0 2017 LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1alpha translation. Nickel 61-67 DNA methyltransferase 3 beta Homo sapiens 39-45 28263966-4 2017 Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. Nickel 109-115 maternally expressed 3 Homo sapiens 132-136 28263966-4 2017 Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. Nickel 109-115 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 177-182 28263966-4 2017 Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. Nickel 109-115 PH domain and leucine rich repeat protein phosphatase 1 Homo sapiens 192-198 28263966-4 2017 Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. Nickel 109-115 hypoxia inducible factor 1 subunit alpha Homo sapiens 230-261 28263966-4 2017 Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. Nickel 109-115 hypoxia inducible factor 1 subunit alpha Homo sapiens 263-273 28263966-5 2017 Mechanistically, MEG3 downregulation was attributed to nickel-induced promoter hypermethylation via elevating DNMT3b expression, whereas PHLPP1 transcriptional inhibition was due to the decreasing interaction of MEG3 with its inhibitory transcription factor c-Jun. Nickel 55-61 maternally expressed 3 Homo sapiens 17-21 28263966-5 2017 Mechanistically, MEG3 downregulation was attributed to nickel-induced promoter hypermethylation via elevating DNMT3b expression, whereas PHLPP1 transcriptional inhibition was due to the decreasing interaction of MEG3 with its inhibitory transcription factor c-Jun. Nickel 55-61 DNA methyltransferase 3 beta Homo sapiens 110-116 28263966-6 2017 Moreover, HIF-1alpha protein translation was upregulated via activating the Akt/p70S6K/S6 axis resultant from PHLPP1 inhibition in nickel responses. Nickel 131-137 hypoxia inducible factor 1 subunit alpha Homo sapiens 10-20 28263966-6 2017 Moreover, HIF-1alpha protein translation was upregulated via activating the Akt/p70S6K/S6 axis resultant from PHLPP1 inhibition in nickel responses. Nickel 131-137 AKT serine/threonine kinase 1 Homo sapiens 76-79 28263966-6 2017 Moreover, HIF-1alpha protein translation was upregulated via activating the Akt/p70S6K/S6 axis resultant from PHLPP1 inhibition in nickel responses. Nickel 131-137 ribosomal protein S6 kinase B1 Homo sapiens 80-86 28263966-6 2017 Moreover, HIF-1alpha protein translation was upregulated via activating the Akt/p70S6K/S6 axis resultant from PHLPP1 inhibition in nickel responses. Nickel 131-137 PH domain and leucine rich repeat protein phosphatase 1 Homo sapiens 110-116 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 DNA methyltransferase 3 beta Homo sapiens 57-63 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 maternally expressed 3 Homo sapiens 78-82 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 167-172 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 196-201 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 PH domain and leucine rich repeat protein phosphatase 1 Homo sapiens 216-222 27323841-0 2017 Dynamic variation of histone H3 trimethyl Lys4 (H3K4me3) and heterochromatin protein 1 (HP1) with employment length in nickel smelting workers. Nickel 119-125 chromobox 5 Homo sapiens 88-91 27323841-1 2017 OBJECTIVE: To investigate the dynamic variation in H3K4me3 and HP1 with employment length in nickel smelting workers. Nickel 93-99 chromobox 5 Homo sapiens 63-66 27323841-5 2017 CONCLUSIONS: Chronic exposure to nickel can induce oxidative damage, and increase H3K4me3 expression and inhibit HP1 expression. Nickel 33-39 chromobox 5 Homo sapiens 113-116 28646124-0 2017 Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. Nickel 0-6 lysine demethylase 3A Homo sapiens 40-46 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 AKT serine/threonine kinase 1 Homo sapiens 253-256 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 ribosomal protein S6 kinase B1 Homo sapiens 257-263 28263966-7 2017 Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. Nickel 30-36 hypoxia inducible factor 1 subunit alpha Homo sapiens 288-298 28263966-8 2017 Our studies provide a significant insight into understanding the alteration and role of MEG3 in nickel-induced lung tumorigenesis. Nickel 96-102 maternally expressed 3 Homo sapiens 88-92 28646124-0 2017 Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. Nickel 0-6 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 69-73 28447093-2 2017 The tosylate was activated by reduced VB12 to form alkyl cobalt(iii), which served as a good alkylating agent for aryl-nickel species, leading to C(sp3)-C(sp2) bond formation. Nickel 119-125 Sp2 transcription factor Homo sapiens 153-158 28517938-1 2017 Escherichia coli RcnR (resistance to cobalt and nickel regulator, EcRcnR) is a metal-responsive repressor of the genes encoding the Ni(II) and Co(II) exporter proteins RcnAB by binding to PRcnAB. Nickel 48-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 143-149 28472268-8 2017 Finally, we find that exposure to low-dose nickel reduces the activity of the MLH1 promoter, but only arsenic leads to long-term MLH1 promoter silencing. Nickel 43-49 mutL homolog 1 Homo sapiens 78-82 28339033-5 2017 The silkworm tropomyosin gene was cloned by reverse transcription and polymerase chain reaction, and the protein was overexpressed in Escherichia coli and purified by affinity chromatography using Nickel-resin. Nickel 197-203 tropomyosin-2 Bombyx mori 13-24 28383289-1 2017 A Tafel slope of 40 mV dec-1 and a very small overpotential were measured for our NiSMoS2G nanocatalyst, prepared using a scalable approach, and consisting of NiS nanoparticles covered by a stabilizing coating of MoS2 nanosheets, on unsophisticated and easy to obtain physical exfoliated graphite. Nickel 82-85 deleted in esophageal cancer 1 Homo sapiens 23-28 28489371-1 2017 Under the conditions of nickel(0) catalysis, enantiomerically enriched vinyl dioxanones engage boroxines or B2(pin)2 in stereospecific cross-coupling to form diverse tetrasubstituted cyclopropanes bearing all-carbon quaternary stereocenters. Nickel 24-30 telomeric repeat binding factor 1 Homo sapiens 108-116 27401113-7 2017 Importantly, treatment of cells with NOX4-targeted siRNA downregulates BRAFV600E-induced NIS repression. Nickel 89-92 NADPH oxidase 4 Homo sapiens 37-41 27401113-9 2017 Remarkably, analysis of human and murine BRAFV600E-mutated thyroid tumors highlights that the level of NOX4 expression is inversely correlated to thyroid differentiation suggesting that other genes involved in thyroid differentiation in addition to NIS might be silenced by a mechanism controlled by NOX4-derived ROS. Nickel 249-252 NADPH oxidase 4 Mus musculus 103-107 28330870-0 2017 Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. Nickel 120-126 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 28330870-5 2017 This study shows that the transcription factor Nrf2 is highly expressed in lung tumor tissue and in nickel-transformed human lung bronchial epithelial BEAS-2B cells (NiT cells). Nickel 100-106 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 28330870-14 2017 These findings indicate that the Nrf2-mediated suppression of apoptosis and promotion of autophagy contribute to nickel-induced transformation and tumorigenesis. Nickel 113-119 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 28235456-3 2017 To confirm their identities, purified HRG and Fgn were demonstrated to react with the nickel-bound enzymes by Western analysis. Nickel 86-92 histidine-rich glycoprotein Oryctolagus cuniculus 38-41 28235456-7 2017 Purified HRG contained trace components larger than HRG that reacted with nickel-enzymes and also with an antibody to HRG by Western analysis, confirming the trace components are related to HRG. Nickel 74-80 histidine-rich glycoprotein Oryctolagus cuniculus 9-12 28235456-7 2017 Purified HRG contained trace components larger than HRG that reacted with nickel-enzymes and also with an antibody to HRG by Western analysis, confirming the trace components are related to HRG. Nickel 74-80 histidine-rich glycoprotein Oryctolagus cuniculus 52-55 28235456-7 2017 Purified HRG contained trace components larger than HRG that reacted with nickel-enzymes and also with an antibody to HRG by Western analysis, confirming the trace components are related to HRG. Nickel 74-80 histidine-rich glycoprotein Oryctolagus cuniculus 52-55 28235456-7 2017 Purified HRG contained trace components larger than HRG that reacted with nickel-enzymes and also with an antibody to HRG by Western analysis, confirming the trace components are related to HRG. Nickel 74-80 histidine-rich glycoprotein Oryctolagus cuniculus 52-55 28196305-3 2017 The size of the nickel nanoparticles increases with the molecular volume of the used anions from about 5 nm for [BF4 ]- to 10 nm for [NTf2 ]- (with 1-alkyl-3-methyl-imidazolium cations). Nickel 16-22 nuclear transport factor 2 Homo sapiens 135-139 28306745-6 2017 Finally, we showed that inhibiting the SLBP mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel"s effects on SLBP may be mediated via epigenetic mechanisms. Nickel 121-127 stem-loop binding protein Homo sapiens 39-43 28287744-1 2017 A nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp2)-O bond cleavage is described. Nickel 2-8 Sp2 transcription factor Homo sapiens 135-140 28364905-0 2017 Memotain: A CAD/CAM nickel-titanium lingual retainer. Nickel 20-26 calmodulin 3 Homo sapiens 16-19 28064036-0 2017 Effects of specimen size and mix ratio on the nickel migration behavior of landfill waste mixed mortar. Nickel 46-52 Mix paired-like homeobox Homo sapiens 29-32 28260736-7 2017 Recombinant Sox (rSox) proteins were purified from whole-cell extracts of E. coli using nickel affinity chromatography. Nickel 88-94 quiescin sulfhydryl oxidase 1 Rattus norvegicus 12-15 28260736-7 2017 Recombinant Sox (rSox) proteins were purified from whole-cell extracts of E. coli using nickel affinity chromatography. Nickel 88-94 quiescin sulfhydryl oxidase 1 Rattus norvegicus 17-21 28306745-6 2017 Finally, we showed that inhibiting the SLBP mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel"s effects on SLBP may be mediated via epigenetic mechanisms. Nickel 121-127 stem-loop binding protein Homo sapiens 141-145 27940032-1 2017 In the present work, coupled and supported NiS and ZnS onto the mechanically prepared clinoptilolite nanoparticles (NC) was prepared and characterized by XRD, FTIR, SEM-EDX, X-ray mapping, DRS, BET, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. Nickel 43-46 sushi repeat containing protein X-linked Homo sapiens 189-192 27940032-1 2017 In the present work, coupled and supported NiS and ZnS onto the mechanically prepared clinoptilolite nanoparticles (NC) was prepared and characterized by XRD, FTIR, SEM-EDX, X-ray mapping, DRS, BET, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. Nickel 43-46 delta/notch like EGF repeat containing Homo sapiens 194-197 27956349-8 2017 SIGNIFICANCE: In this study, we reveal that the inhibition profiles of divalent metal cations as to zinc uptake via mZIP8 apparently differ from those for mZIP1, especially in the affinity and inhibition manner of nickel. Nickel 214-220 solute carrier family 39 (zinc transporter), member 1 Mus musculus 155-160 28211695-0 2017 Synthesis of Benzoisoselenazolone Derivatives by Nickel-Catalyzed Dehydrogenative Direct Selenation of C(sp2)-H Bonds with Elemental Selenium in Air. Nickel 49-55 Sp2 transcription factor Homo sapiens 103-108 28004401-8 2017 Agents such as iron chelators, and heavy metals like cobalt and nickel were demonstrated to be effective in maintaining the HIF-1alpha level in the nerve. Nickel 64-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 124-134 28177601-0 2017 Nickel Ligation of the N-Terminal Amine of HypA Is Required for Urease Maturation in Helicobacter pylori. Nickel 0-6 pre-mRNA processing factor 40 homolog A Homo sapiens 43-47 27695030-5 2017 METHODS: Pure glkA and protein-tyrosine kinase (BYK) of S. aureus ATCC 12600 were obtained by fractionating the cytosolic fractions of glkA1 and BYK-1 expressing recombinant clones through nickel metal chelate column. Nickel 189-195 AT695_RS09780 Staphylococcus aureus 14-18 28007571-0 2017 Multiple nickel-sensitive targets elicit cardiac arrhythmia in isolated mouse hearts after pituitary adenylate cyclase-activating polypeptide-mediated chronotropy. Nickel 9-15 adenylate cyclase activating polypeptide 1 Mus musculus 91-141 28117567-1 2017 We introduce a "non-noble metal" based SERS active nanobiosensor using a self-assembled 3D hybrid nickel nanonetwork. Nickel 98-104 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 39-43 28112920-2 2017 Recent advances have shown that nickel catalysts are active toward the coupling of sp3-carbon electrophiles and that well-controlled, light-driven coupling systems are possible. Nickel 32-38 Sp3 transcription factor Homo sapiens 83-86 28117567-6 2017 The two results, one being the CV molecule proved that nickel nanonetwork is indeed SERS active and the second being the GSH biomolecule detection at both 532 and 785 nm, confirm that the nanonetwork is a biosensor which has potential for both in vivo and in vitro sensing. Nickel 55-61 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 84-88 28117567-8 2017 The functionalized self-assembled 3D hybrid nickel nanonetwork exhibits electromagnetic and charge transfer based SERS activation mechanisms. Nickel 44-50 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 114-118 28157173-3 2017 Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients diagnosed by a double-blind placebo-controlled(DBPC)challenge,and to identify the characteristics of NCWS patients with nickel allergy. Nickel 66-72 Y-box binding protein 2 Homo sapiens 146-150 27565855-0 2016 Integration of nickel doping with loading on graphene for enhanced adsorptive and catalytic properties of CdS nanoparticles towards visible light degradation of some antibiotics. Nickel 15-21 CDP-diacylglycerol synthase 1 Homo sapiens 106-109 27966348-4 2017 After the isomerization of Int1, the oxidative addition of the C-H bond of pyridine across the nickel-acetylene moiety occurs via a transition state TS2 to form a Ni(II)(NHC) pyridyl vinyl intermediate Int3. Nickel 95-101 Wnt family member 1 Homo sapiens 27-31 27966348-4 2017 After the isomerization of Int1, the oxidative addition of the C-H bond of pyridine across the nickel-acetylene moiety occurs via a transition state TS2 to form a Ni(II)(NHC) pyridyl vinyl intermediate Int3. Nickel 95-101 notch receptor 4 Homo sapiens 202-206 27973630-0 2017 Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7. Nickel 96-102 sialic acid binding Ig like lectin 7 Homo sapiens 168-176 27747921-5 2017 In the most nickel-exposed work site (refinery), there were 14 lung cancers (SIR 2.01) and 3 sinonasal cancers (SIR 26.7, 95%). Nickel 12-18 sirtuin 1 Homo sapiens 77-82 28250280-8 2017 In this study, we demonstrate that human P2X7R exhibits different sensitivity to nickel and calcium compared with the case of the mouse one, while there is no species difference in the sensitivity of their P2X7Rs to magnesium, zinc and copper, suggesting that the effects of magnesium, zinc and copper on P2X7R-associated pathophysiological events in humans might be predicted from those in mice. Nickel 81-87 purinergic receptor P2X 7 Homo sapiens 41-46 28819572-4 2017 This case report describes for the first time a CAD/CAM zirconium bar as a bonded mandibular fixed retainer with 2-year follow-up in a patient who is subjected to long-term treatment with fixed orthodontic appliance and suspected to have metal hypersensitivity as shown by the considerable increase of nickel and chromium concentrations in a sample of patient"s unstimulated saliva. Nickel 302-308 calmodulin 3 Homo sapiens 52-55 28857653-8 2017 Our latest study showed that the Plk3 protein is suppressed by hypoxia or nickel treatment via the ubiquitin/proteasome system. Nickel 74-80 polo like kinase 3 Homo sapiens 33-37 28420001-0 2017 Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells. Nickel 61-67 nicotinamide N-methyltransferase Homo sapiens 0-32 28420001-4 2017 However, the role of NNMT in nickel-induced histone methylation remains unclear. Nickel 29-35 nicotinamide N-methyltransferase Homo sapiens 21-25 28420001-9 2017 RESULTS: Exposure of BEAS-2B cells to nickel increased H3K9 dimethylation (H3K9me2), suppressed the expressions of H3K9me2-associated genes (MAP2K3 and DKK1), and induced NNMT repression at both the protein and mRNA levels. Nickel 38-44 mitogen-activated protein kinase kinase 3 Homo sapiens 141-147 28420001-9 2017 RESULTS: Exposure of BEAS-2B cells to nickel increased H3K9 dimethylation (H3K9me2), suppressed the expressions of H3K9me2-associated genes (MAP2K3 and DKK1), and induced NNMT repression at both the protein and mRNA levels. Nickel 38-44 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 152-156 28420001-9 2017 RESULTS: Exposure of BEAS-2B cells to nickel increased H3K9 dimethylation (H3K9me2), suppressed the expressions of H3K9me2-associated genes (MAP2K3 and DKK1), and induced NNMT repression at both the protein and mRNA levels. Nickel 38-44 nicotinamide N-methyltransferase Homo sapiens 171-175 28420001-10 2017 Furthermore, over-expression of NNMT inhibited nickel-induced H3K9me2 and altered the cellular SAM/SAH ratio. Nickel 47-53 nicotinamide N-methyltransferase Homo sapiens 32-36 28420001-12 2017 CONCLUSIONS: These findings indicate that the repression of NNMT may underlie nickel-induced H3K9 dimethylation by altering the cellular SAM/SAH ratio. Nickel 78-84 nicotinamide N-methyltransferase Homo sapiens 60-64 28451200-3 2017 Described here is the use of primary and secondary ammonium alkylsilicates, which undergo facile C(sp3)-C(sp2) cross-coupling with borylated aryl bromide partners under photoredox/nickel dual catalysis conditions. Nickel 180-186 Sp2 transcription factor Homo sapiens 104-109 28509315-0 2017 Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically. Nickel 66-72 caspase 3 Homo sapiens 0-9 28509315-10 2017 The enhanced expression of caspase-3 was accompanied by increased nickel concentration in saliva. Nickel 66-72 caspase 3 Homo sapiens 27-36 28509315-11 2017 CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals. Nickel 36-42 caspase 3 Homo sapiens 93-102 28509315-11 2017 CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals. Nickel 179-185 caspase 3 Homo sapiens 93-102 27531173-2 2017 Through this pathway, TSHR regulates the expression of sodium-iodide symporter (NIS) to complete iodine intake. Nickel 80-83 thyroid stimulating hormone receptor Mus musculus 22-26 27531173-2 2017 Through this pathway, TSHR regulates the expression of sodium-iodide symporter (NIS) to complete iodine intake. Nickel 80-83 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 55-78 27531173-10 2017 CONCLUSION: The lower expression of NIS in lactating breast may be due to the 173 AA deletion in the TSHR resulting the lower binding of TSH to the TSHR. Nickel 36-39 thyroid stimulating hormone receptor Mus musculus 101-105 27531173-10 2017 CONCLUSION: The lower expression of NIS in lactating breast may be due to the 173 AA deletion in the TSHR resulting the lower binding of TSH to the TSHR. Nickel 36-39 thyroid stimulating hormone receptor Mus musculus 148-152 27840971-0 2017 Inhibiting beta-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Nickel 153-156 catenin beta 1 Homo sapiens 11-23 27840971-10 2017 beta-catenin nuclear translocation in tumor cells was accompanied by abnormal subcellular localization of NIS. Nickel 106-109 catenin beta 1 Homo sapiens 0-12 27989162-3 2016 This reaction occurs via metal-ligand cooperation (MLC) involving a 2-electron reduction at nickel. Nickel 92-98 modulator of VRAC current 1 Homo sapiens 51-54 27565855-1 2016 Water dispersible, highly efficient nickel doped CdS nanoparticles anchored on graphene nanosheets as a photocatalyst for cephalexin and sulfamethoxazole photodegradation have been prepared in a facile microwave-furnace assisted method. Nickel 36-42 CDP-diacylglycerol synthase 1 Homo sapiens 49-52 27816644-8 2016 HSA binding interaction studies showed that the cobalt and nickel complexes can quench the intrinsic fluorescence of HSA through static quenching process. Nickel 59-65 albumin Bos taurus 0-3 27951644-0 2016 Mechanism of Selective Nickel Transfer from HypB to HypA, Escherichia coli [NiFe]-Hydrogenase Accessory Proteins. Nickel 23-29 hypA Escherichia coli 52-56 27951644-2 2016 The synthesis of the bimetallic catalytic center requires a suite of accessory proteins, and the penultimate step, nickel insertion, is facilitated by the metallochaperones HypA and HypB. Nickel 115-121 hypA Escherichia coli 173-177 27951644-3 2016 In Escherichia coli, nickel moves from a site in the GTPase domain of HypB to HypA in a process accelerated by GDP. Nickel 21-27 hypA Escherichia coli 78-82 27951644-5 2016 Integral to this work was His2Gln HypA, a mutant with attenuated nickel affinity that does not support hydrogenase production in E. coli. Nickel 65-71 hypA Escherichia coli 34-38 27862759-3 2016 The nickel-catalytic system displays good chemoselectivity between the two C(sp2 )-halide coupling partners, thus demonstrating a mechanistic pathway distinct from other stepwise protocols. Nickel 4-10 Sp2 transcription factor Homo sapiens 75-80 27815607-6 2016 Using the yellow-emitting Macrolampis sp2 firefly luciferase and site-directed mutagenesis, we show that the residues H310 and E354 constitute two critical sites for metal sensitivity that can be engineered to increase sensitivity to zinc, nickel, and mercury. Nickel 240-246 Sp2 transcription factor Homo sapiens 38-41 26810082-7 2016 Significant reductions in concentrations of aluminium, cadmium, copper, lead and/or nickel were found in tap waters where households were successfully treating low-pH groundwaters, and similar adventitious results were found for arsenic and nickel where treatment was installed for iron and/or manganese removal, and successful treatment specifically to decrease tap water arsenic concentrations was observed at two properties where it was installed. Nickel 84-90 nuclear RNA export factor 1 Homo sapiens 105-108 27816644-8 2016 HSA binding interaction studies showed that the cobalt and nickel complexes can quench the intrinsic fluorescence of HSA through static quenching process. Nickel 59-65 albumin Bos taurus 117-120 27709749-2 2016 Using these reagents, an efficient and high-throughput continuous flow process was developed to perform a dual iridium- and nickel-catalyzed C(sp2 )-C(sp3 ) coupling by circumventing solubility issues associated with potassium trifluoroborate salts. Nickel 124-130 Sp2 transcription factor Homo sapiens 141-146 27638195-4 2016 RESULTS: TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide symporter (NIS) mRNA. Nickel 197-200 insulin like growth factor 1 Homo sapiens 13-18 27638195-4 2016 RESULTS: TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide symporter (NIS) mRNA. Nickel 197-200 iodothyronine deiodinase 2 Homo sapiens 127-131 27638195-6 2016 The IGF-1R tyrosine kinase inhibitor linsitinib inhibited TSH-stimulated upregulation of NIS but not TG, indicating that NIS regulation is in part IGF-1R dependent and occurs via receptor crosstalk. Nickel 89-92 insulin like growth factor 1 receptor Homo sapiens 4-10 27638195-6 2016 The IGF-1R tyrosine kinase inhibitor linsitinib inhibited TSH-stimulated upregulation of NIS but not TG, indicating that NIS regulation is in part IGF-1R dependent and occurs via receptor crosstalk. Nickel 121-124 insulin like growth factor 1 receptor Homo sapiens 4-10 27638195-6 2016 The IGF-1R tyrosine kinase inhibitor linsitinib inhibited TSH-stimulated upregulation of NIS but not TG, indicating that NIS regulation is in part IGF-1R dependent and occurs via receptor crosstalk. Nickel 121-124 insulin like growth factor 1 receptor Homo sapiens 147-153 27638195-9 2016 Pharmacological inhibition of ERK1/2 by the MEK1/2 inhibitor U0126 and of Akt by MK-2206 virtually abolished NIS stimulation by TSH and the synergistic effect of IGF-1. Nickel 109-112 mitogen-activated protein kinase 3 Homo sapiens 30-36 27638195-9 2016 Pharmacological inhibition of ERK1/2 by the MEK1/2 inhibitor U0126 and of Akt by MK-2206 virtually abolished NIS stimulation by TSH and the synergistic effect of IGF-1. Nickel 109-112 mitogen-activated protein kinase kinase 1 Homo sapiens 44-50 27638195-9 2016 Pharmacological inhibition of ERK1/2 by the MEK1/2 inhibitor U0126 and of Akt by MK-2206 virtually abolished NIS stimulation by TSH and the synergistic effect of IGF-1. Nickel 109-112 AKT serine/threonine kinase 1 Homo sapiens 74-77 27886000-15 2016 CONCLUSIONS: In this study, micro layered esthetic nickel titanium wires are found biocompatible among other wires and NaF and CHX mouthwashes can be recommend for their good corrosion resistance during fixed orthodontic therapy. Nickel 51-57 C-X-C motif chemokine ligand 8 Homo sapiens 119-122 27869178-9 2016 We conclude that interactions of nickel ions with histidine residues in domain B help to maintain the conformation of the C-terminal region to conserve the integrity of the HpGroES structure and modulate IL-8 release. Nickel 33-39 C-X-C motif chemokine ligand 8 Homo sapiens 204-208 27934487-0 2016 Nickel-Catalyzed Diaryl Ketone Synthesis by N-C Cleavage: Direct Negishi Cross-Coupling of Primary Amides by Site-Selective N,N-Di-Boc Activation. Nickel 0-6 BOC cell adhesion associated, oncogene regulated Homo sapiens 131-134 27842611-6 2016 This allowed us to distinguish between nickel-labeled tau and background electron-dense structures, and we found that tau localized to 20-25 nm straight filaments in oligodendroglia-like cells and neurons. Nickel 39-45 microtubule associated protein tau Homo sapiens 54-57 27731623-3 2016 Herein, a crystalline/amorphous Co/CoP film was facilely prepared on nickel foam (NF) by a one-step electrodeposition technique at room temperature, named Co/CoP-NF. Nickel 69-75 caspase recruitment domain family member 16 Homo sapiens 35-38 27731623-3 2016 Herein, a crystalline/amorphous Co/CoP film was facilely prepared on nickel foam (NF) by a one-step electrodeposition technique at room temperature, named Co/CoP-NF. Nickel 69-75 caspase recruitment domain family member 16 Homo sapiens 158-161 28051835-3 2016 Nanoparticles containing nickel, that increase the risk for pleural diseases, induced increased levels of IP-10 in rat pleural mesothelial cells. Nickel 25-31 C-X-C motif chemokine ligand 10 Rattus norvegicus 106-111 27846569-2 2016 The activity of MCR is dependent on the unique nickel-containing tetrapyrrole known as coenzyme F430. Nickel 47-53 coenzyme-B sulfoethylthiotransferase subunit beta Methanosarcina acetivorans C2A 16-19 27690408-4 2016 Using a volumetric method, that is, measuring methane production over time, revealed that anaerobic digestion was stimulated by the addition of 5 mg L-1 nickel(II), and cobalt(II), and their mixture in day(s). Nickel 153-159 immunoglobulin kappa variable 1-16 Homo sapiens 149-152 27598512-1 2016 The Kondo effect of a Co atom on Cu(100) was investigated with a low-temperature scanning tunneling microscope using a monoatomically sharp nickel tip. Nickel 140-146 TOR signaling pathway regulator Homo sapiens 147-150 27711361-1 2016 A dimeric molybdenum precursor and nickel ions are used to synthesize a symmetric heteropentanuclear complex, [Mo2NiMo2(tpda)4(NCS)2]. Nickel 35-41 cytosolic thiouridylase subunit 2 Homo sapiens 127-132 27467530-0 2016 Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Nickel 42-48 sequestosome 1 Homo sapiens 16-22 27467530-0 2016 Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Nickel 42-48 sequestosome 1 Homo sapiens 23-26 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 60-66 sequestosome 1 Homo sapiens 38-44 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 60-66 sequestosome 1 Homo sapiens 45-48 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 60-66 tumor necrosis factor Homo sapiens 137-140 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 109-115 sequestosome 1 Homo sapiens 38-44 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 109-115 sequestosome 1 Homo sapiens 45-48 27467530-3 2016 In the current studies, we identified SQSTM1/p62 as a novel nickel-upregulated protein that is important for nickel-induced inflammatory TNF expression, subsequently resulting in transformation of human bronchial epithelial cells. Nickel 109-115 tumor necrosis factor Homo sapiens 137-140 27467530-4 2016 We found that nickel exposure induced SQSTM1 protein upregulation in human lung epithelial cells in vitro and in mouse lung tissues in vivo. Nickel 14-20 sequestosome 1 Homo sapiens 38-44 27467530-6 2016 Further studies revealed that the knockdown of SQSTM1 expression dramatically inhibited transformation of human lung epithelial cells upon chronic nickel exposure, whereas ectopic expression of SQSTM1 promoted such transformation. Nickel 147-153 sequestosome 1 Homo sapiens 47-53 27467530-7 2016 Mechanistic studies showed that the SQSTM1 upregulation by nickel was the compromised result of upregulating SQSTM1 mRNA transcription and promoting SQSTM1 protein degradation. Nickel 59-65 sequestosome 1 Homo sapiens 36-42 27467530-7 2016 Mechanistic studies showed that the SQSTM1 upregulation by nickel was the compromised result of upregulating SQSTM1 mRNA transcription and promoting SQSTM1 protein degradation. Nickel 59-65 sequestosome 1 Homo sapiens 109-115 27467530-7 2016 Mechanistic studies showed that the SQSTM1 upregulation by nickel was the compromised result of upregulating SQSTM1 mRNA transcription and promoting SQSTM1 protein degradation. Nickel 59-65 sequestosome 1 Homo sapiens 109-115 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 21-27 sequestosome 1 Homo sapiens 38-44 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 21-27 mechanistic target of rapamycin kinase Homo sapiens 112-116 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 21-27 unc-51 like autophagy activating kinase 1 Homo sapiens 117-121 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 21-27 beclin 1 Homo sapiens 122-127 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 21-27 sequestosome 1 Homo sapiens 164-170 27467530-8 2016 We demonstrated that nickel-initiated SQSTM1 protein degradation is mediated by macroautophagy/autophagy via an MTOR-ULK1-BECN1 axis, whereas RELA is important for SQSTM1 transcriptional upregulation following nickel exposure. Nickel 210-216 sequestosome 1 Homo sapiens 38-44 27467530-9 2016 Furthermore, SQSTM1 upregulation exhibited its promotion of nickel-induced cell transformation through exerting an impetus for nickel-induced inflammatory TNF mRNA stability. Nickel 60-66 sequestosome 1 Homo sapiens 13-19 27467530-9 2016 Furthermore, SQSTM1 upregulation exhibited its promotion of nickel-induced cell transformation through exerting an impetus for nickel-induced inflammatory TNF mRNA stability. Nickel 60-66 tumor necrosis factor Homo sapiens 155-158 27467530-9 2016 Furthermore, SQSTM1 upregulation exhibited its promotion of nickel-induced cell transformation through exerting an impetus for nickel-induced inflammatory TNF mRNA stability. Nickel 127-133 sequestosome 1 Homo sapiens 13-19 27467530-9 2016 Furthermore, SQSTM1 upregulation exhibited its promotion of nickel-induced cell transformation through exerting an impetus for nickel-induced inflammatory TNF mRNA stability. Nickel 127-133 tumor necrosis factor Homo sapiens 155-158 27467530-10 2016 Consistently, the MTOR-ULK1-BECN1 autophagic cascade acted as an inhibitory effect on nickel-induced TNF expression and cell transformation. Nickel 86-92 mechanistic target of rapamycin kinase Homo sapiens 18-22 27467530-10 2016 Consistently, the MTOR-ULK1-BECN1 autophagic cascade acted as an inhibitory effect on nickel-induced TNF expression and cell transformation. Nickel 86-92 unc-51 like autophagy activating kinase 1 Homo sapiens 23-27 27467530-10 2016 Consistently, the MTOR-ULK1-BECN1 autophagic cascade acted as an inhibitory effect on nickel-induced TNF expression and cell transformation. Nickel 86-92 beclin 1 Homo sapiens 28-33 27467530-10 2016 Consistently, the MTOR-ULK1-BECN1 autophagic cascade acted as an inhibitory effect on nickel-induced TNF expression and cell transformation. Nickel 86-92 tumor necrosis factor Homo sapiens 101-104 27467530-11 2016 Collectively, our results demonstrate a novel SQSTM1 regulatory network that promotes a nickel-induced tumorigenic effect in human bronchial epithelial cells, which is negatively controlled by an autophagic cascade following nickel exposure. Nickel 88-94 sequestosome 1 Homo sapiens 46-52 27467530-11 2016 Collectively, our results demonstrate a novel SQSTM1 regulatory network that promotes a nickel-induced tumorigenic effect in human bronchial epithelial cells, which is negatively controlled by an autophagic cascade following nickel exposure. Nickel 225-231 sequestosome 1 Homo sapiens 46-52 27490125-7 2016 Allergic contact dermatitis is defined as having Th1/Th17-centered inflammation, especially with nickel-induced disease, but additional pathways, including Th2 and Th22, are upregulated with other allergens (i.e. fragrance). Nickel 97-103 negative elongation factor complex member C/D Homo sapiens 49-52 27258090-1 2016 Photoredox/nickel dual catalysis via single electron transmetalation allows coupling of Csp(3)-Csp(2) hybridized centers under mild conditions. Nickel 11-17 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 88-91 27573304-13 2016 Immunohistochemical staining showed that HeLa-TERTNIS xenograft tumors expressed higher levels of NIS and caspase-3 and lower levels of Ki-67 than HeLa xenograft tumors. Nickel 50-53 caspase 3 Homo sapiens 106-115 27573304-15 2016 Thus, NIS-based gene therapy and imaging using the hTERT promoter and 188Re may be possible. Nickel 6-9 telomerase reverse transcriptase Homo sapiens 51-56 27488040-0 2016 Nickel-smelting fumes increased the expression of HIF-1alpha through PI3K/ERK pathway in NIH/3T3 cells. Nickel 0-6 hypoxia inducible factor 1, alpha subunit Mus musculus 50-60 27488040-0 2016 Nickel-smelting fumes increased the expression of HIF-1alpha through PI3K/ERK pathway in NIH/3T3 cells. Nickel 0-6 mitogen-activated protein kinase 1 Mus musculus 74-77 27626938-4 2016 A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures. Nickel 214-220 interleukin 6 Homo sapiens 46-59 27626938-4 2016 A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures. Nickel 214-220 mitogen-activated protein kinase 8 Homo sapiens 65-68 27458162-4 2016 We evaluated a hypoxia-based imaging and therapy strategy to target expression of the sodium iodide symporter (NIS) gene to experimental hepatocellular carcinoma (HCC) delivered by MSCs.MSCs engineered to express transgenes driven by a hypoxia-responsive promoter showed robust transgene induction under hypoxia as demonstrated by mCherry expression in tumor cell spheroid models, or radioiodide uptake using NIS. Nickel 111-114 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 86-109 27258090-1 2016 Photoredox/nickel dual catalysis via single electron transmetalation allows coupling of Csp(3)-Csp(2) hybridized centers under mild conditions. Nickel 11-17 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 95-98 27472556-4 2016 By using this photoredox catalysis and nickel catalysis approach, a direct Csp(2)-Csp(3) reductive cross-coupling of aryl bromides with alkyl bromides is achieved under mild conditions without stoichiometric metal reductants. Nickel 39-45 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 75-78 27472556-4 2016 By using this photoredox catalysis and nickel catalysis approach, a direct Csp(2)-Csp(3) reductive cross-coupling of aryl bromides with alkyl bromides is achieved under mild conditions without stoichiometric metal reductants. Nickel 39-45 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 82-85 27157666-1 2016 The sodium iodide symporter (NIS) as well-characterized theranostic gene represents an outstanding tool to target different cancer types allowing noninvasive imaging of functional NIS expression and therapeutic radioiodide application. Nickel 29-32 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 4-27 28111599-0 2016 Nickel-Catalyzed C-3 Direct Arylation of Pyridinium Ions for the Synthesis of 1-Azafluorenes. Nickel 0-6 complement C3 Homo sapiens 17-20 28111599-2 2016 The first nickel-catalyzed C-3 direct arylation of pyridine derivatives to provide a new approach to valuable 1-azafluorene pharmacophore frameworks was developed. Nickel 10-16 complement C3 Homo sapiens 27-30 31968842-1 2016 A novel isohedral 3-periodic net (i.e. a net with one kind of tile), showing a Cairo pentagonal tiling projection on the Euclidean plane, has been identified in a series of site-modified CuCN/CuSCN networks, namely, [Cu6 (SCN)2 (CN)6 Ni(tpy)2 ]n (1), [Cu6 (SCN)(CN)7 Ni(tpy)2 ]n (2) and [Cu6 (CN)8 Ni(tpy)2 ]n (3) (tpy=2,2":6"",2""-terpyridine). Nickel 235-243 growth factor independent 1 transcriptional repressor Homo sapiens 217-227 27208469-6 2016 We used multiple regression models of FT4 and TSH that included perchlorate equivalent concentration (PEC, which estimates combined inhibitory effects of the anions perchlorate, SCN, and NO3 on the NIS). Nickel 198-201 NBL1, DAN family BMP antagonist Homo sapiens 187-190 27157666-1 2016 The sodium iodide symporter (NIS) as well-characterized theranostic gene represents an outstanding tool to target different cancer types allowing noninvasive imaging of functional NIS expression and therapeutic radioiodide application. Nickel 180-183 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 4-27 27157666-4 2016 In vitro iodide uptake studies demonstrated high transduction efficiency and cMET-specificity of NIS-encoding polyplexes (cMBP2-PEG-Stp/NIS) compared to polyplexes without targeting ligand (Ala-PEG-Stp/NIS) and without coding DNA (cMBP2-PEG-Stp/Antisense-NIS). Nickel 97-100 met proto-oncogene Mus musculus 77-81 27157666-4 2016 In vitro iodide uptake studies demonstrated high transduction efficiency and cMET-specificity of NIS-encoding polyplexes (cMBP2-PEG-Stp/NIS) compared to polyplexes without targeting ligand (Ala-PEG-Stp/NIS) and without coding DNA (cMBP2-PEG-Stp/Antisense-NIS). Nickel 97-100 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 132-135 27157666-4 2016 In vitro iodide uptake studies demonstrated high transduction efficiency and cMET-specificity of NIS-encoding polyplexes (cMBP2-PEG-Stp/NIS) compared to polyplexes without targeting ligand (Ala-PEG-Stp/NIS) and without coding DNA (cMBP2-PEG-Stp/Antisense-NIS). Nickel 97-100 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 198-201 27157666-4 2016 In vitro iodide uptake studies demonstrated high transduction efficiency and cMET-specificity of NIS-encoding polyplexes (cMBP2-PEG-Stp/NIS) compared to polyplexes without targeting ligand (Ala-PEG-Stp/NIS) and without coding DNA (cMBP2-PEG-Stp/Antisense-NIS). Nickel 97-100 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 198-201 27467577-3 2016 Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. Nickel 98-104 toll like receptor 4 Homo sapiens 53-57 27389658-3 2016 Here, for the first time, we address the electrochemical actuation and the associated stress-charge coefficients of bulk nanoporous nickel (np-Ni) in both strongly (NaOH) and weakly (NaF) adsorbed electrolytes. Nickel 132-138 C-X-C motif chemokine ligand 8 Homo sapiens 183-186 26095832-5 2016 plNAD-MDH was expressed in an Escherichia coli system and purified using nickel-affinity chromatography followed by size exclusion chromatography. Nickel 73-79 malate dehydrogenase Arabidopsis thaliana 6-9 26931411-2 2016 Sensitivity to zinc, nickel and ascorbate of native Cav3.2 channels is significantly impeded in the dorsal root ganglion (DRG) neurons of this KI mouse. Nickel 21-27 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 52-58 27307058-0 2016 Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair. Nickel 95-101 XPA, DNA damage recognition and repair factor Homo sapiens 48-51 27307058-10 2016 Thus, we derived a putative cytotoxic mechanism associated with the nickel ion, where the Ni(2+) disrupts the conformation of the XPA Zn-finger, directly weakening its interaction with RPA70N, and thus lowering the effectiveness of the NER process. Nickel 68-74 XPA, DNA damage recognition and repair factor Homo sapiens 130-133 26931411-7 2016 Cav3.2 channels are modulated by low concentrations of metal ions (nickel, zinc) and redox agents, which involves the histidine 191 (H191) in the channel"s extracellular IS3-IS4 loop. Nickel 67-73 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 0-6 25427687-0 2016 The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. Nickel 23-29 lysine demethylase 6B Homo sapiens 51-56 27452194-0 2016 Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Nickel 24-30 prostaglandin-endoperoxide synthase 2 Mus musculus 15-20 27283431-15 2016 The mechanism of the eosinophilia involves the direct release of intracellular eotaxin due to the rupture of cells by the accumulated solubilized nickel ions in the phagolysosome. Nickel 146-152 C-C motif chemokine ligand 11 Rattus norvegicus 79-86 27256230-10 2016 CONCLUSION: Genetic analysis of TPO, NIS, DUOX2 and TG gene in 5 unrelated CH patients with thyroid dyshormonogenesis revealed two novel DUOX2 mutations, both were biallelic and monoallelic heterozygous mutations in DUOX2 associated with transient CH. Nickel 37-40 dual oxidase 2 Homo sapiens 137-142 27256230-10 2016 CONCLUSION: Genetic analysis of TPO, NIS, DUOX2 and TG gene in 5 unrelated CH patients with thyroid dyshormonogenesis revealed two novel DUOX2 mutations, both were biallelic and monoallelic heterozygous mutations in DUOX2 associated with transient CH. Nickel 37-40 dual oxidase 2 Homo sapiens 137-142 27383320-0 2016 Role of TNF-alpha polymorphism in patients with nickel allergy: a marker of susceptibility to contact polysensitization. Nickel 48-54 tumor necrosis factor Homo sapiens 8-17 27383320-5 2016 PATIENTS AND METHODS: To evaluate the expression of TNF-alpha polymorphism in patients with allergic contact dermatitis and in healthy people, 41 patients with allergic contact dermatitis to nickel and 40 healthy controls were enrolled. Nickel 191-197 tumor necrosis factor Homo sapiens 52-61 27383320-10 2016 CONCLUSIONS: The carriage of the TNFA-308 A/A and GA genotype may act as a marker of enhanced susceptibility to contact polysensitization, indicating that TNF-alpha is a key regulator of the initiation of delayed-type hypersensitivity reactions, the polymorphism seems to be not enough for the development of nickel monosensitization. Nickel 309-315 tumor necrosis factor Homo sapiens 33-37 27383320-10 2016 CONCLUSIONS: The carriage of the TNFA-308 A/A and GA genotype may act as a marker of enhanced susceptibility to contact polysensitization, indicating that TNF-alpha is a key regulator of the initiation of delayed-type hypersensitivity reactions, the polymorphism seems to be not enough for the development of nickel monosensitization. Nickel 309-315 tumor necrosis factor Homo sapiens 155-164 26926590-1 2016 A TRAIL-CM4 fusion protein in soluble form with tumor selective apoptosis and antibacterial functions was expressed in the Escherichia coli expression system and isolated through dialysis refolding and histidine-tag Nickel-affinity purification. Nickel 216-222 TNF superfamily member 10 Homo sapiens 2-7 26650895-8 2016 By inhibiting Ape1 and TxnRd1 functions, we found that both enzymes are crucial for TSH and TSH plus Se stimulation of Pax8 activity and mediate the Nis response to Se treatment. Nickel 149-152 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 14-18 26650895-8 2016 By inhibiting Ape1 and TxnRd1 functions, we found that both enzymes are crucial for TSH and TSH plus Se stimulation of Pax8 activity and mediate the Nis response to Se treatment. Nickel 149-152 thioredoxin reductase 1 Rattus norvegicus 23-29 26650895-11 2016 CONCLUSION: Nis expression is controlled by Txn/Ape1 through a TSH/Se-dependent mechanism. Nickel 12-15 thioredoxin 1 Rattus norvegicus 44-47 26650895-11 2016 CONCLUSION: Nis expression is controlled by Txn/Ape1 through a TSH/Se-dependent mechanism. Nickel 12-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 48-52 27108928-6 2016 KU-55933, a selective ATM kinase inhibitor, partly rescued NIS expression and iodide transport in DNA-damaged cells. Nickel 59-62 ATM serine/threonine kinase Homo sapiens 22-25 27108928-7 2016 Prolonged ATM inhibition in healthy cells also repressed NIS-mediated iodide transport. Nickel 57-60 ATM serine/threonine kinase Homo sapiens 10-13 27108928-9 2016 Together, these findings indicate that NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM-mediated mechanisms. Nickel 39-42 ATM serine/threonine kinase Homo sapiens 134-137 26872612-4 2016 Site-directed mutagenesis of Pax8 and NF-kappaB cis-acting elements abrogated the iodide-induced NIS transcription repression. Nickel 97-100 paired box 8 Rattus norvegicus 29-33 26872612-7 2016 PI3K/Akt pathway activation by iodide-induced ROS production is involved in the transcriptional repression of NIS expression. Nickel 110-113 AKT serine/threonine kinase 1 Rattus norvegicus 5-8 26872612-8 2016 In conclusion, the results indicated that excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity. Nickel 84-87 paired box 8 Rattus norvegicus 130-134 26872612-8 2016 In conclusion, the results indicated that excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity. Nickel 84-87 synaptotagmin 1 Rattus norvegicus 139-142 26612876-9 2016 Comparing the highest with the lowest quartile of urinary nickel, the ORs (95% CIs) were 1.99 (1.46 to 2.78) for albuminuria, 1.44 (1.07 to 1.95) for beta2-microglobulinuria, and 2.95 (1.74 to 4.97) for both albuminuria and beta2-microglobulinuria, after adjustment for demographic characteristics, lifestyle behaviours, body mass index, hypertension and diabetes. Nickel 58-64 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 150-155 26612876-11 2016 CONCLUSIONS: This study suggested that urinary nickel levels were positively associated with albuminuria and beta2-microglobulinuria in Chinese men and women, who had relatively low background nickel exposure. Nickel 47-53 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 109-114 26792558-4 2016 The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF. Nickel 38-44 insulin like growth factor 1 Homo sapiens 176-182 26792558-4 2016 The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF. Nickel 38-44 colony stimulating factor 2 Homo sapiens 184-190 26792558-4 2016 The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF. Nickel 38-44 fibroblast growth factor 2 Homo sapiens 195-199 26991295-2 2016 Three isolates, MT-4, UBT-18, and IBT-I, showed high levels of nickel tolerance, whereas MT-4, UBT-18, and IBT-II showed better tolerance of cadmium than the other isolates. Nickel 63-69 metallothionein 4 Homo sapiens 16-20 26814609-4 2016 The NIS-expressing vaccinia virus (VV-NIS), GLV-1h153, was tested in in vitro analyzes of viral cell killing, combination with radiotherapy, NIS expression, cellular radioiodide uptake and apoptotic cell death in PC3, DU145, LNCaP and WPMY-1 human prostate cell lines. Nickel 4-7 proprotein convertase subtilisin/kexin type 1 Mus musculus 213-216 26749286-5 2016 The increase of Th1-type immune responses was confirmed in vivo in Gfi1-deficient mice using a murine model of nickel allergy and delayed-type hypersensitivity (DTH). Nickel 111-117 negative elongation factor complex member C/D, Th1l Mus musculus 16-19 26749286-5 2016 The increase of Th1-type immune responses was confirmed in vivo in Gfi1-deficient mice using a murine model of nickel allergy and delayed-type hypersensitivity (DTH). Nickel 111-117 growth factor independent 1 transcription repressor Mus musculus 67-71 26919691-5 2016 Insertion of the iron center signals to the metallochaperones HypA, HypB, and SlyD to selectively deliver the nickel to the active site. Nickel 110-116 pre-mRNA processing factor 40 homolog A Homo sapiens 62-66 26919691-5 2016 Insertion of the iron center signals to the metallochaperones HypA, HypB, and SlyD to selectively deliver the nickel to the active site. Nickel 110-116 SET domain containing 2, histone lysine methyltransferase Homo sapiens 68-72 26989187-1 2016 In this issue of Blood, Shen et al demonstrate that the vesicular stomatitis virus (VSV)-murine interferon beta (IFNbeta)-sodium iodide symporter (NIS) (VSV-mIFNbeta-NIS) oncolytic virus has significant antileukemia activity, which is enhanced when combined with an anti-programmed death-ligand 1 (PD-L1) antibody. Nickel 147-150 interferon beta 1, fibroblast Mus musculus 96-111 26989187-1 2016 In this issue of Blood, Shen et al demonstrate that the vesicular stomatitis virus (VSV)-murine interferon beta (IFNbeta)-sodium iodide symporter (NIS) (VSV-mIFNbeta-NIS) oncolytic virus has significant antileukemia activity, which is enhanced when combined with an anti-programmed death-ligand 1 (PD-L1) antibody. Nickel 147-150 interferon beta 1, fibroblast Mus musculus 113-120 26409021-0 2016 Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin. Nickel 0-6 insulin Bos taurus 88-95 26409021-1 2016 An ultra-sensitive electrochemical sensor for the detection of insulin was fabricated, using low-cost and environmentally friendly nickel nanoparticles (NiNPs) by ion implantation. Nickel 131-137 insulin Bos taurus 63-70 26673575-1 2016 BACKGROUND: The earFold implantable clip system is a new treatment for prominent ears using an implant made from nickel-titanium alloy, forged into a predetermined shape. Nickel 114-120 CAP-Gly domain containing linker protein 1 Homo sapiens 37-41 31968788-4 2016 The as-obtained CoNi2 S4 sample with NO3 - as the anion in the nickel cobalt salt displayed an ultrahigh specific capacitance of 2714 F g-1 at 1 A g-1 and excellent rate capability (64.8 % capacity retention at 20 A g-1 ). Nickel 16-24 NBL1, DAN family BMP antagonist Homo sapiens 37-40 31968788-7 2016 The study indicates that the as-obtained CoNi2 S4 grown on carbon cloth prepared with NO3 - as the anion will be a promising electrode material for supercapacitors. Nickel 41-49 NBL1, DAN family BMP antagonist Homo sapiens 86-89 26809061-3 2016 Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1. Nickel 0-6 cyclin dependent kinase inhibitor 1A Homo sapiens 68-71 26809061-3 2016 Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1. Nickel 0-6 cyclin dependent kinase inhibitor 1A Homo sapiens 72-76 26809061-3 2016 Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1. Nickel 0-6 cyclin dependent kinase inhibitor 1A Homo sapiens 77-81 26809061-3 2016 Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1. Nickel 0-6 cyclin dependent kinase 1 Homo sapiens 138-142 26809061-3 2016 Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1. Nickel 0-6 cyclin B1 Homo sapiens 167-176 26809061-6 2016 p53 reporter gene assay and analyses of p53, Puma, Bax, and Bcl-2 protein levels indicated that NAC inhibited nickel(II)-induced activation of p53-mediated mitochondrial apoptotic pathway. Nickel 110-116 BCL2 apoptosis regulator Homo sapiens 60-65 26857255-1 2016 A novel improved preconcentration method known as rapidly synergistic cloud point extraction (RS-CPE) was established for nickel preconcentration and determination prior to its determination by flame atomic absorption spectrometry. Nickel 122-128 carboxypeptidase E Homo sapiens 97-100 27036791-3 2016 The HT1080 cells expressing XRCC1-RFP were irradiated with single high energy nickel ions, and time-lapse images of the irradiated cells were obtained online. Nickel 78-84 X-ray repair cross complementing 1 Homo sapiens 28-33 26592602-0 2016 Simultaneous determination of cobalt and nickel in vitamin B12 samples using high-resolution continuum source atomic absorption spectrometry. Nickel 41-47 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 59-62 26902198-2 2016 METHODS: Three kinds of treatment models were firstly established with alcohol, ATRA, and transfection of beta-catenin shRNA in undifferentiated human thyroid cancer cell line-SW1736.Then the expressions of sodium iodide symporter (NIS), beta-catenin and its regulating factors, epithelial-mensechymal transition (EMT)-phenotype, invasion and metastasis associated proteins were further measured in above three cell models.After that, the influence of ATRA on the functional expression of NIS, iodine uptake potency, tumor growth curve and treatment effect inducing by radioactive iodine was comparatively analyzed in vitro and in vivo trials. Nickel 232-235 catenin beta 1 Homo sapiens 106-118 26902198-2 2016 METHODS: Three kinds of treatment models were firstly established with alcohol, ATRA, and transfection of beta-catenin shRNA in undifferentiated human thyroid cancer cell line-SW1736.Then the expressions of sodium iodide symporter (NIS), beta-catenin and its regulating factors, epithelial-mensechymal transition (EMT)-phenotype, invasion and metastasis associated proteins were further measured in above three cell models.After that, the influence of ATRA on the functional expression of NIS, iodine uptake potency, tumor growth curve and treatment effect inducing by radioactive iodine was comparatively analyzed in vitro and in vivo trials. Nickel 489-492 catenin beta 1 Homo sapiens 106-118 26902198-6 2016 CONCLUSIONS: ATRA can increase functional expression of NIS via downregulating transcriptional activity of beta-catenin and promote isotope sensitivity to radio-iodine in human undifferentiated thyroid cancer. Nickel 56-59 catenin beta 1 Homo sapiens 107-119 26828317-1 2016 Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. Nickel 47-53 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 118-121 26828317-1 2016 Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. Nickel 47-53 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 125-128 26780400-2 2016 In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transformed by arsenic, chromium, nickel and vanadium. Nickel 152-158 SATB homeobox 2 Homo sapiens 40-45 26784023-3 2016 The free-standing PtCuNi/CNF@CF monolith exhibits high porosities, a well-defined geometry shape, outstanding electron conductivity, and a unique characteristic of localizing platinum-copper-nickel nanoparticles in the tips of carbon nanofibers. Nickel 191-197 NPHS1 adhesion molecule, nephrin Homo sapiens 25-28 26716579-1 2016 A new cascade three-component haloazidation of benzene-tethered 1,7-enynes for the formation of biologically interesting azidylated 3,4-dihydroquinolin-2(1H)-ones has been achieved under mild and metal-free conditions using TMSN3 as a N3 source and NIS (or NBS or NCS) as a halogen source. Nickel 249-252 nibrin Homo sapiens 257-260 26771707-0 2016 Nickel-Catalyzed Double Bond Transposition of Alkenyl Boronates for in Situ syn-Selective Allylboration Reactions. Nickel 0-6 synemin Homo sapiens 76-79 29081943-0 2016 Nickel-catalyzed trifluoromethylthiolation of Csp2-O bonds. Nickel 0-6 regulator of calcineurin 2 Homo sapiens 46-50 29081943-1 2016 While nickel catalysts have previously been shown to activate even the least reactive Csp2-O bonds, i.e. aryl ethers, in the context of C-C bond formation, little is known about the reactivity limits and molecular requirements for the introduction of valuable functional groups under homogeneous nickel catalysis. Nickel 6-12 regulator of calcineurin 2 Homo sapiens 86-90 26572557-7 2016 The radio-inducible Egr1 promoter induced an 131I radiation positive feedback effect absorbed by NIS. Nickel 97-100 early growth response 1 Homo sapiens 20-24 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 aryl hydrocarbon receptor Homo sapiens 70-95 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 aryl hydrocarbon receptor Homo sapiens 97-100 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-137 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 aryl hydrocarbon receptor Rattus norvegicus 185-188 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 aryl hydrocarbon receptor Rattus norvegicus 185-188 26519956-5 2016 Moreover, stimulation with PCB118 resulted in the upregulation of the aryl hydrocarbon receptor (AhR)-responsive gene cytochrome P450 1A1 in FRTL-5 cells; whereas pretreatment with the AhR inhibitor alpha-naphthoflavone or AhR small interfering RNA (siRNA) suppressed AhR, CYP1A1, IL-6, and ICAM-1 and restored NIS expression. Nickel 311-314 aryl hydrocarbon receptor Rattus norvegicus 185-188 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. Nickel 252-255 mitogen-activated protein kinase 8 Rattus norvegicus 53-76 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. Nickel 252-255 mitogen-activated protein kinase 8 Rattus norvegicus 78-81 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. Nickel 252-255 mitogen-activated protein kinase 8 Rattus norvegicus 161-164 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. Nickel 252-255 interleukin 6 Rattus norvegicus 214-218 26680370-1 2016 A new cascade three-component halosulfonylation of 1,7-enynes for efficient synthesis of densely functionalized 3,4-dihydroquinolin-2(1H)-ones has been established from readily accessible arylsulfonyl hydrazides and NIS (or NBS). Nickel 216-219 nibrin Homo sapiens 224-227 26628255-2 2016 The key to this hightly efficient C-N bond borylative cleavage depends on the appropriate choice of the nickel catalyst Ni(COD)2, ICy HCl as a ligand, and the use of 2-ethoxyethanol as the cosolvent. Nickel 104-110 COD2 Homo sapiens 123-128 26607348-0 2016 Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. Nickel 38-44 toll-like receptor 4 Mus musculus 107-111 26607348-0 2016 Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. Nickel 38-44 mitogen-activated protein kinase 14 Mus musculus 112-115 26607348-0 2016 Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. Nickel 38-44 cAMP responsive element binding protein 1 Mus musculus 116-120 27965526-0 2016 Fracture Resistance of K3 Nickel-Titanium Files Made from Different Thermal Treatments. Nickel 26-32 keratin 3 Homo sapiens 23-25 25045119-0 2016 Involvement of L-type Ca2+ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. Nickel 63-69 C-X-C motif chemokine ligand 8 Homo sapiens 78-91 25045119-5 2016 The underlying mechanisms of nickel-induced IL-8 were investigated. Nickel 29-35 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 25045119-6 2016 We found that nickel induced IL-8 gene expression via the L-type Ca(2+) channel, Toll-like receptor-4 (TRL-4) and nuclear factor NF-kappaB signal transduction pathways. Nickel 14-20 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 25045119-6 2016 We found that nickel induced IL-8 gene expression via the L-type Ca(2+) channel, Toll-like receptor-4 (TRL-4) and nuclear factor NF-kappaB signal transduction pathways. Nickel 14-20 nuclear factor kappa B subunit 1 Homo sapiens 129-138 25045119-7 2016 Nickel activated NF-kappaB expression through extracellular signal-regulated kinase 1/2 phosphorylation and then increased IL-8 expression. Nickel 0-6 nuclear factor kappa B subunit 1 Homo sapiens 17-26 25045119-7 2016 Nickel activated NF-kappaB expression through extracellular signal-regulated kinase 1/2 phosphorylation and then increased IL-8 expression. Nickel 0-6 mitogen-activated protein kinase 3 Homo sapiens 46-85 25045119-7 2016 Nickel activated NF-kappaB expression through extracellular signal-regulated kinase 1/2 phosphorylation and then increased IL-8 expression. Nickel 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 26397922-2 2016 The three-dimensional (3D) porous microstructure of the as-fabricated nickel foam-graphene/simonkolleite (NiF-G/SimonK) composite is beneficial to electrolyte penetration and ions exchange, whereas graphene provide improved electronic conductivity. Nickel 70-76 S100 calcium binding protein A9 Homo sapiens 106-109 26653736-8 2016 The elevated secretion of IL-2 under nickel sulfate stimulation in vitro was exclusively found in atopic patients with nickel allergy infected by S. aureus. Nickel 37-43 interleukin 2 Homo sapiens 26-30 30351722-5 2016 Increased serum level of vanadium disorders transport of apoproteins incorporated into lipoproteins; increased serum level of nickel activates hemolysis of RBC, disorders speed of hemoglobin-haptoglobin complex formation and its subsequent utilization by hepatocytes. Nickel 126-132 haptoglobin Homo sapiens 191-202 26802650-10 2016 Our current data revealed that NDRG2 overexpression enhanced NIS level in TT cells and increased their iodine uptake in vitro. Nickel 61-64 NDRG family member 2 Homo sapiens 31-36 26472731-8 2016 However, SST increases AKT activation and the inhibition of the Src/PI3K/AKT pathway increases NIS levels in SST-treated cells. Nickel 95-98 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 64-67 26472731-8 2016 However, SST increases AKT activation and the inhibition of the Src/PI3K/AKT pathway increases NIS levels in SST-treated cells. Nickel 95-98 AKT serine/threonine kinase 1 Homo sapiens 73-76 26472731-8 2016 However, SST increases AKT activation and the inhibition of the Src/PI3K/AKT pathway increases NIS levels in SST-treated cells. Nickel 95-98 somatostatin Homo sapiens 109-112 26472731-10 2016 Moreover, we demonstrate that SST might regulates NIS expression through a Src/PI3K/AKT-dependent mechanism, but not through ERK1/2 signalling, showing the main role of this hormone in thyroid function. Nickel 50-53 somatostatin Homo sapiens 30-33 26472731-10 2016 Moreover, we demonstrate that SST might regulates NIS expression through a Src/PI3K/AKT-dependent mechanism, but not through ERK1/2 signalling, showing the main role of this hormone in thyroid function. Nickel 50-53 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 75-78 26472731-10 2016 Moreover, we demonstrate that SST might regulates NIS expression through a Src/PI3K/AKT-dependent mechanism, but not through ERK1/2 signalling, showing the main role of this hormone in thyroid function. Nickel 50-53 AKT serine/threonine kinase 1 Homo sapiens 84-87 26802650-11 2016 Furthermore, (99m)TcO4(-) radionuclide imaging of the xenograft tumors indicated that NDRG2 could promote NIS-mediated radionuclide transport. Nickel 106-109 NDRG family member 2 Homo sapiens 86-91 26695298-2 2016 HPPD was produced by cloning the hppd gene from Arabidopsis thaliana in E. coli, followed by overexpression and purification by nickel-histidine affinity. Nickel 128-134 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 0-4 26289851-15 2016 Knockdown of miR-21 significantly increased the expression of PDCD4, p21, NIS, and TG while leading to decreased expression of Oct-4, ABCG2, and Mcl-1.Taken together, the results suggest that miR-21, as an oncomiR, has a role not only in stemness state but also in tumor growth, differentiation, and apoptosis. Nickel 74-77 microRNA 21 Homo sapiens 13-19 26264613-0 2016 FoxP3 in papillary thyroid carcinoma induces NIS repression through activation of the TGF-beta1/Smad signaling pathway. Nickel 45-48 forkhead box P3 Homo sapiens 0-5 26264613-0 2016 FoxP3 in papillary thyroid carcinoma induces NIS repression through activation of the TGF-beta1/Smad signaling pathway. Nickel 45-48 transforming growth factor beta 1 Homo sapiens 86-95 26264613-4 2016 We found that FoxP3 was associated with decreased NIS expression. Nickel 50-53 forkhead box P3 Homo sapiens 14-19 26264613-5 2016 Lentiviral-mediated FoxP3-overexpressing cells were constructed and real-time PCR and western blotting were performed to evaluate the expression of NIS. Nickel 148-151 forkhead box P3 Homo sapiens 20-25 26264613-8 2016 However, treatment with neutralizing TGF-beta1 antibody partially abrogated FoxP3-induced NIS repression. Nickel 90-93 transforming growth factor beta 1 Homo sapiens 37-46 26264613-8 2016 However, treatment with neutralizing TGF-beta1 antibody partially abrogated FoxP3-induced NIS repression. Nickel 90-93 forkhead box P3 Homo sapiens 76-81 26264613-9 2016 These findings suggest that FoxP3 could compromise NIS expression by inducing TGF-beta1. Nickel 51-54 forkhead box P3 Homo sapiens 28-33 26264613-9 2016 These findings suggest that FoxP3 could compromise NIS expression by inducing TGF-beta1. Nickel 51-54 transforming growth factor beta 1 Homo sapiens 78-87 27054738-4 2016 If the PFAS-containing wastewater is mixed with other wastewater streams, specifically from nickel plating drag out solution or when pH values >5, the treatment process is ineffective. Nickel 92-98 phosphoribosylformylglycinamidine synthase Homo sapiens 7-11 26535918-10 2015 In addition, influence of NOX on AHR activation was also observed in cells treated with the SH-reactive metals cadmium, mercury, and nickel. Nickel 133-139 aryl hydrocarbon receptor Homo sapiens 33-36 26492302-5 2015 Compared to a single His6-tag fused at one extremity of a MP, the presence of several His6-tags carried by the APol belt surrounding the transmembrane domain of a MP increases remarkably the affinity of the protein/APol complex for nickel ion-bearing SPR chips, whereas it does not show such a strong effect on an IMAC resin. Nickel 232-238 apolipoprotein L1 Homo sapiens 111-115 26492302-5 2015 Compared to a single His6-tag fused at one extremity of a MP, the presence of several His6-tags carried by the APol belt surrounding the transmembrane domain of a MP increases remarkably the affinity of the protein/APol complex for nickel ion-bearing SPR chips, whereas it does not show such a strong effect on an IMAC resin. Nickel 232-238 apolipoprotein L1 Homo sapiens 215-219 26573213-2 2015 Various analysis methods (ex and in situ XRD, TEM, Raman, XPS, TPR, TPD) were used to investigate the structural forms of the catalysts, and these results indicated that the deposition of nickel species resulted in the formation of two main active types of the catalyst components: NiO strongly or weakly interacted with the surface and Ni-Ce-O solid solution. Nickel 188-194 translocated promoter region, nuclear basket protein Homo sapiens 63-66 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Nickel 35-41 hepsin Mus musculus 91-94 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Nickel 35-41 hepsin Mus musculus 99-102 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Nickel 165-171 hepsin Mus musculus 91-94 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Nickel 165-171 hepsin Mus musculus 99-102 26641249-5 2015 We observed that Hpn acts as a nickel-sequestration protein, while Hpn-2 is not. Nickel 31-37 hepsin Mus musculus 17-20 26641249-8 2015 Based on these data, we present a model where Hpn and Hpn-2 participate in a common pathway of controlled nickel transfer to urease. Nickel 106-112 hepsin Mus musculus 46-49 26641249-8 2015 Based on these data, we present a model where Hpn and Hpn-2 participate in a common pathway of controlled nickel transfer to urease. Nickel 106-112 hepsin Mus musculus 54-57 26003825-8 2015 THRbeta expression was directly correlated with NIS, TPO, Tg and TSH-R, and inversely correlated to miR-21, -146a, -181a and -221 expression. Nickel 48-51 thyroid hormone receptor beta Homo sapiens 0-7 26496819-0 2015 Safety evaluation of traces of nickel and chrome in cosmetics: The case of Dead Sea mud. Nickel 31-37 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 80-83 26496819-3 2015 Dead Sea mud is a popular natural ingredient of cosmetic products in which nickel and chrome residues are likely to occur. Nickel 75-81 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 5-8 26496819-4 2015 OBJECTIVE: To analyze the potential systemic and local toxicity of Dead Sea mud taking into consideration Dead Sea muds" natural content of nickel and chrome. Nickel 140-146 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 72-75 26496819-4 2015 OBJECTIVE: To analyze the potential systemic and local toxicity of Dead Sea mud taking into consideration Dead Sea muds" natural content of nickel and chrome. Nickel 140-146 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 111-114 26496819-7 2015 RESULTS AND CONCLUSIONS: Following exposure to Dead Sea mud, MoS (margin of safety) calculations for nickel and chrome indicate no toxicological concern for systemic toxicity. Nickel 101-107 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 52-55 26338896-4 2015 Here, we evaluated the role of ERRgamma in the regulation of NIS function in ATC cells using GSK5182, an inverse agonist of ERRgamma. Nickel 61-64 estrogen related receptor gamma Homo sapiens 31-39 26338896-14 2015 CONCLUSION: These findings suggest that the inverse agonist of ERRgamma enhances the responsiveness of radioiodine therapy by modulating NIS function in ATC cells via the regulation of ERRgamma and the MAP kinase signaling pathway. Nickel 137-140 estrogen related receptor gamma Homo sapiens 63-71 26338896-14 2015 CONCLUSION: These findings suggest that the inverse agonist of ERRgamma enhances the responsiveness of radioiodine therapy by modulating NIS function in ATC cells via the regulation of ERRgamma and the MAP kinase signaling pathway. Nickel 137-140 estrogen related receptor gamma Homo sapiens 185-193 26458050-0 2015 Liquid-Crystal Biosensor Based on Nickel-Nanosphere-Induced Homeotropic Alignment for the Amplified Detection of Thrombin. Nickel 34-40 coagulation factor II, thrombin Homo sapiens 113-121 26458050-1 2015 A new liquid-crystal (LC)-based sensor operated by nickel nanosphere (NiNS)-induced homeotropic alignment for the label-free monitoring of thrombin was reported. Nickel 51-57 coagulation factor II, thrombin Homo sapiens 139-147 26386501-4 2015 Combining NIs with ACEIs is unsafe because of an unacceptably high prevalence of angioedema, which may be mediated by elevated levels of endogenous bradykinin. Nickel 10-13 kininogen 1 Homo sapiens 148-158 26395868-3 2015 The samples were doped with nickel, which was confirmed using the combined results of HRTEM, SEM, XRD, Raman, BET, and XPS measurements. Nickel 28-34 delta/notch like EGF repeat containing Homo sapiens 110-113 26338373-9 2015 RESULTS: This study shows that tumors measuring <=20 mm exhibited higher prevalence of BRAF V600E mutation, which correlated with aggressive histopathological parameters, higher risk of recurrence, and lower expression of NIS and TPO. Nickel 226-229 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 91-95 26338373-10 2015 Although this correlation was not found when microPTC were evaluated, we show that tumors measuring 7-10 mm, which were positive for BRAF mutation, presented more aggressive features and lower expression of NIS and TPO. Nickel 208-211 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 134-138 26213306-7 2015 Here we report about the potential of bovine lactoferrin (bLf) which is a known chemo preventive and emerging safe anti-cancer bio drug, as well as a natural transcriptional activator of genes, to enhance the endogenous expression of NIS in Y79 and Weri-Rb-1 cells. Nickel 234-237 lactotransferrin Bos taurus 45-56 26216069-4 2015 This oxidative photocatalyzed process can be efficiently merged with nickel-catalyzed Csp2-Csp3 cross-coupling reactions. Nickel 69-75 regulator of calcineurin 2 Homo sapiens 86-90 26422475-3 2015 In this article, a recombinant porcine beta2-AR was produced in the inner membrane of HEK293 cells and purified from crude membrane protein by nickel-nitrilotriacetic acid affinity chromatography. Nickel 143-149 adrenoceptor beta 2 Homo sapiens 39-47 26223478-0 2015 Nickel-Catalyzed Cyclopropanation with NMe4OTf and nBuLi. Nickel 0-6 NME/NM23 nucleoside diphosphate kinase 4 Homo sapiens 39-43 28793549-0 2015 Accelerated Degradation Test and Predictive Failure Analysis of B10 Copper-Nickel Alloy under Marine Environmental Conditions. Nickel 75-81 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 64-67 28793549-1 2015 This paper studies the corrosion behavior of B10 copper-nickel alloy in marine environment. Nickel 56-62 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 45-48 25385356-4 2015 The mature part of the lipase was expressed in Escherichia coli and purified by nickel affinity chromatography. Nickel 80-86 lipase Staphylococcus aureus 23-29 26163317-4 2015 We show in cells treated with nickel an upregulation of ATG8 that is independent of CRR1, a global regulator of copper signaling in Chlamydomonas. Nickel 30-36 uncharacterized protein Chlamydomonas reinhardtii 84-88 26464256-1 2015 Our study explored the dynamic changes in and the relationship between the DNA damage marker 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the DNA repair marker 8-hydroxyguanine DNA glycosidase 1 (hOGG1) according to the length of occupational employment in nickel smelting workers. Nickel 253-259 8-oxoguanine DNA glycosylase Homo sapiens 192-197 26464256-5 2015 There were significant differences between employment length and hOGG1 levels, with subjects employed in nickel smelting for 10-14 y showing the highest levels of hOGG1. Nickel 105-111 8-oxoguanine DNA glycosylase Homo sapiens 65-70 26464256-5 2015 There were significant differences between employment length and hOGG1 levels, with subjects employed in nickel smelting for 10-14 y showing the highest levels of hOGG1. Nickel 105-111 8-oxoguanine DNA glycosylase Homo sapiens 163-168 26464256-7 2015 DNA damage was increased with employment length among nickel smelting workers and was related to the inhibition of hOGG1 repair capacity. Nickel 54-60 8-oxoguanine DNA glycosylase Homo sapiens 115-120 25966046-7 2015 The mRNA levels for the tumor suppressor gene p53 and the apoptotic genes bax, CASP3 and CASP9 were up-regulated, while the anti-apoptotic gene bcl-2 was down-regulated following nickel ferrite NP exposure. Nickel 179-185 tumor protein p53 Homo sapiens 46-49 25966046-7 2015 The mRNA levels for the tumor suppressor gene p53 and the apoptotic genes bax, CASP3 and CASP9 were up-regulated, while the anti-apoptotic gene bcl-2 was down-regulated following nickel ferrite NP exposure. Nickel 179-185 BCL2 apoptosis regulator Homo sapiens 144-149 26051273-6 2015 Nickel is a known hypoxia-mimetic that activates hypoxia inducible factor-1alpha (HIF1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 49-80 25644787-0 2015 Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway. Nickel 137-140 AKT serine/threonine kinase 1 Homo sapiens 126-129 25644787-0 2015 Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway. Nickel 137-140 forkhead box O3 Homo sapiens 130-136 25644787-10 2015 Our research suggests that PCB118 may induce thyrocyte dysfunction through the Akt/FoxO3a/NIS signalling pathway, which provides potential new insights for finding interventions to counteract the damage to the human body caused by PCBs. Nickel 90-93 AKT serine/threonine kinase 1 Homo sapiens 79-82 25644787-10 2015 Our research suggests that PCB118 may induce thyrocyte dysfunction through the Akt/FoxO3a/NIS signalling pathway, which provides potential new insights for finding interventions to counteract the damage to the human body caused by PCBs. Nickel 90-93 forkhead box O3 Homo sapiens 83-89 26044615-0 2015 Toxicity of nickel ions and comprehensive analysis of nickel ion-associated gene expression profiles in THP-1 cells. Nickel 54-60 GLI family zinc finger 2 Homo sapiens 104-109 26044615-8 2015 The mRNA expression levels of RELB, FIGF, SPI-1, CXCL16 and CRLF2 were significantly increased following nickel treatment. Nickel 105-111 RELB proto-oncogene, NF-kB subunit Homo sapiens 30-34 26044615-8 2015 The mRNA expression levels of RELB, FIGF, SPI-1, CXCL16 and CRLF2 were significantly increased following nickel treatment. Nickel 105-111 Spi-1 proto-oncogene Homo sapiens 42-47 26044615-8 2015 The mRNA expression levels of RELB, FIGF, SPI-1, CXCL16 and CRLF2 were significantly increased following nickel treatment. Nickel 105-111 C-X-C motif chemokine ligand 16 Homo sapiens 49-55 26044615-8 2015 The mRNA expression levels of RELB, FIGF, SPI-1, CXCL16 and CRLF2 were significantly increased following nickel treatment. Nickel 105-111 cytokine receptor like factor 2 Homo sapiens 60-65 26044615-9 2015 The results of the present study suggested that nickel ions exert toxic effects on THP-1 cell growth, which may indicate toxicity of the nickel ion during treatment of congenital heart disease. Nickel 48-54 GLI family zinc finger 2 Homo sapiens 83-88 26044615-9 2015 The results of the present study suggested that nickel ions exert toxic effects on THP-1 cell growth, which may indicate toxicity of the nickel ion during treatment of congenital heart disease. Nickel 137-143 GLI family zinc finger 2 Homo sapiens 83-88 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 GLI family zinc finger 2 Homo sapiens 71-76 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 erythropoietin receptor Homo sapiens 84-88 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 RELB proto-oncogene, NF-kB subunit Homo sapiens 90-94 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 Spi-1 proto-oncogene Homo sapiens 102-107 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 transforming growth factor beta 1 Homo sapiens 109-118 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 C-X-C motif chemokine ligand 16 Homo sapiens 120-126 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 61-67 cytokine receptor like factor 2 Homo sapiens 131-136 26044615-10 2015 The identification of genes modified by the toxic effects of nickel on THP-1 cells (EPOR, RELB, FIGF, SPI-1, TGF-beta1, CXCL16 and CRLF2) may aid in the development of interventional measures for the treatment/prevention of nickel ion-associated toxic effects during the treatment of congenital heart disease. Nickel 224-230 GLI family zinc finger 2 Homo sapiens 71-76 26026961-0 2015 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Nickel 0-6 epidermal growth factor receptor Homo sapiens 25-29 26026961-0 2015 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Nickel 0-6 epidermal growth factor receptor Homo sapiens 86-90 26026961-0 2015 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Nickel 115-121 epidermal growth factor receptor Homo sapiens 86-90 26026961-1 2015 We recently reported that nickel accumulation in lung tissues may be associated with an increased in p53 mutation risk via reduced DNA repair activity. Nickel 26-32 tumor protein p53 Homo sapiens 101-104 26026961-2 2015 Here, we hypothesized that nickel accumulation in lung tissues could contribute to EGFR mutations in never-smokers with lung cancer. Nickel 27-33 epidermal growth factor receptor Homo sapiens 83-87 26026961-4 2015 The prevalence of EGFR mutations was significantly higher in the high-nickel subgroup than in the low-nickel subgroup. Nickel 70-76 epidermal growth factor receptor Homo sapiens 18-22 26026961-4 2015 The prevalence of EGFR mutations was significantly higher in the high-nickel subgroup than in the low-nickel subgroup. Nickel 102-108 epidermal growth factor receptor Homo sapiens 18-22 26026961-6 2015 Mechanistically, SPRY2 and RECK expressions were decreased by nickel-induced miR-21 via activation of the EGFR/NF-kappaB signaling pathway, which promoted invasiveness in lung cancer cells, and particularly in the cells with EGFR L858R expression vector transfection. Nickel 62-68 sprouty RTK signaling antagonist 2 Homo sapiens 17-22 26026961-6 2015 Mechanistically, SPRY2 and RECK expressions were decreased by nickel-induced miR-21 via activation of the EGFR/NF-kappaB signaling pathway, which promoted invasiveness in lung cancer cells, and particularly in the cells with EGFR L858R expression vector transfection. Nickel 62-68 reversion inducing cysteine rich protein with kazal motifs Homo sapiens 27-31 26026961-6 2015 Mechanistically, SPRY2 and RECK expressions were decreased by nickel-induced miR-21 via activation of the EGFR/NF-kappaB signaling pathway, which promoted invasiveness in lung cancer cells, and particularly in the cells with EGFR L858R expression vector transfection. Nickel 62-68 microRNA 21 Homo sapiens 77-83 26026961-6 2015 Mechanistically, SPRY2 and RECK expressions were decreased by nickel-induced miR-21 via activation of the EGFR/NF-kappaB signaling pathway, which promoted invasiveness in lung cancer cells, and particularly in the cells with EGFR L858R expression vector transfection. Nickel 62-68 epidermal growth factor receptor Homo sapiens 106-110 26026961-6 2015 Mechanistically, SPRY2 and RECK expressions were decreased by nickel-induced miR-21 via activation of the EGFR/NF-kappaB signaling pathway, which promoted invasiveness in lung cancer cells, and particularly in the cells with EGFR L858R expression vector transfection. Nickel 62-68 epidermal growth factor receptor Homo sapiens 225-229 26026961-7 2015 The patients" nickel levels were associated with miR-21 expression levels. Nickel 14-20 microRNA 21 Homo sapiens 49-55 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Nickel 39-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Nickel 39-45 heme oxygenase 1 Mus musculus 112-116 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Nickel 39-45 mitogen-activated protein kinase 14 Mus musculus 121-124 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Nickel 39-45 signal transducer and activator of transcription 1 Mus musculus 125-130 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Nickel 39-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 131-140 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Nickel 220-226 nuclear factor, erythroid derived 2, like 2 Mus musculus 173-195 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Nickel 220-226 nuclear factor, erythroid derived 2, like 2 Mus musculus 197-201 25957741-9 2015 Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice. Nickel 201-207 mitogen-activated protein kinase 14 Mus musculus 38-41 25957741-9 2015 Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice. Nickel 201-207 signal transducer and activator of transcription 1 Mus musculus 46-96 25957741-9 2015 Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice. Nickel 201-207 signal transducer and activator of transcription 1 Mus musculus 98-103 25957741-9 2015 Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice. Nickel 201-207 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 143-152 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Nickel 62-68 nuclear factor, erythroid derived 2, like 2 Mus musculus 146-150 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Nickel 62-68 heme oxygenase 1 Mus musculus 151-155 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Nickel 62-68 mitogen-activated protein kinase 14 Mus musculus 160-163 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Nickel 62-68 signal transducer and activator of transcription 1 Mus musculus 164-169 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Nickel 62-68 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 170-179 26051273-6 2015 Nickel is a known hypoxia-mimetic that activates hypoxia inducible factor-1alpha (HIF1alpha). Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-91 26051273-7 2015 Nickel-induced inhibition of fatty acid oxidation was blunted in HIF1alpha knockout fibroblasts, implicating HIF1alpha as one contributor to the mechanism. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 65-74 26051273-7 2015 Nickel-induced inhibition of fatty acid oxidation was blunted in HIF1alpha knockout fibroblasts, implicating HIF1alpha as one contributor to the mechanism. Nickel 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 109-118 26051273-8 2015 Additionally, nickel down-regulated the protein levels of the key fatty acid oxidation enzyme very long-chain acyl-CoA dehydrogenase (VLCAD) in a dose-dependent fashion. Nickel 14-20 acyl-CoA dehydrogenase very long chain Homo sapiens 94-132 26051273-8 2015 Additionally, nickel down-regulated the protein levels of the key fatty acid oxidation enzyme very long-chain acyl-CoA dehydrogenase (VLCAD) in a dose-dependent fashion. Nickel 14-20 acyl-CoA dehydrogenase very long chain Homo sapiens 134-139