PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28334921-4	2017	In this study resorufin beta-D-glucuronide, a substrate of the beta-Glucuronidase enzyme, was added to patient samples to determine if proper hydrolysis had occurred.	beta-d-glucuronide	24-42	glucuronidase beta	Homo sapiens	63-81
28334921-7	2017	The beta-Glucuronidase enzyme was used to hydrolyze the benzodiazepine analytes as well as resorufin beta-D-glucuronide.	beta-d-glucuronide	101-119	glucuronidase beta	Homo sapiens	4-22
17121932-1	2006	Multidrug resistance-associated protein 1 (MRP1) mediates the ATP-dependent efflux of endobiotics and xenobiotics, including estradiol 17-(beta-d-glucuronide), leukotriene C(4), and the reduced glutathione conjugate of 4-hydroxy-2-nonenal (HNE), a highly reactive product of lipid peroxidation.	beta-d-glucuronide	139-157	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-41
25236865-3	2015	Since its discovery in 1998, the substrates of BCRP have been rapidly expanding to include not only therapeutic agents but also physiological substances such as estrone-3-sulfate, 17beta-estradiol 17-(beta-D-glucuronide) and uric acid.	beta-d-glucuronide	201-219	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-51
18761402-8	2008	The affinity of 17beta-estradiol 17-(beta-d-glucuronide), methotrexate, vinblastine, and probenecid to monkey MRP2 was higher than that to human MRP2.	beta-d-glucuronide	37-55	ATP binding cassette subfamily C member 2	Homo sapiens	110-114
27659809-7	2016	Transport of the prototypical physiological MRP4 substrates prostaglandin E2 and 17beta-estradiol 17-(beta-d-glucuronide) by the six variants was also differentially affected.	beta-d-glucuronide	102-120	ATP binding cassette subfamily C member 4	Homo sapiens	44-48
17121932-1	2006	Multidrug resistance-associated protein 1 (MRP1) mediates the ATP-dependent efflux of endobiotics and xenobiotics, including estradiol 17-(beta-d-glucuronide), leukotriene C(4), and the reduced glutathione conjugate of 4-hydroxy-2-nonenal (HNE), a highly reactive product of lipid peroxidation.	beta-d-glucuronide	139-157	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	43-47
11748225-3	2002	The basal-to-apical transport of 17 beta estradiol 17 beta-d-glucuronide (E(2)17 beta G), pravastatin, and leukotriene C(4) (LTC(4)), which are substrates of OATP2 and MRP2, was significantly higher than that in the opposite direction in the double-transfected cells.	beta-d-glucuronide	54-72	solute carrier organic anion transporter family member 1B1	Homo sapiens	158-163
15795089-7	2005	MRP3-mediated transport of 17beta-estradiol 17-(beta-d-glucuronide) and methotrexate were partially inhibited by trans-hydroxycotinine-O-glucuronide (300 microM) (by 70% and 50%, respectively), whereas nicotine-N-glucuronide and cotinine-N-glucuronide had no effect.	beta-d-glucuronide	48-66	ATP binding cassette subfamily C member 3	Homo sapiens	0-4
16879057-3	2006	HEX and beta-glucuronidase act on the 4-nitrophenyl derivatives N-acetyl-beta-glucosamine and beta-D-glucuronide, respectively, to produce 4-nitrophenol, which can be measured at 405 nm on a microplate reader.	beta-d-glucuronide	94-112	glucuronidase beta	Homo sapiens	8-26
16146333-6	2005	In addition to its role to confer resistance against chemotherapeutic agents, BCRP actively transports structurally diverse organic molecules, conjugated or unconjugated, such as estrone-3-sulfate, 17beta-estradiol 17-(beta-D-glucuronide), and methotrexate.	beta-d-glucuronide	219-237	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-82
8779894-0	1996	Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter.	beta-d-glucuronide	13-31	solute carrier organic anion transporter family member 1A2	Homo sapiens	65-69
11429411-1	2001	Murine multidrug resistance protein 1 (mrp1), differs from its human ortholog (MRP1) in that it fails to confer anthracycline resistance and transports the MRP1 substrate, 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG), very poorly.	beta-d-glucuronide	193-211	ATP binding cassette subfamily B member 1	Homo sapiens	7-37
11429411-1	2001	Murine multidrug resistance protein 1 (mrp1), differs from its human ortholog (MRP1) in that it fails to confer anthracycline resistance and transports the MRP1 substrate, 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG), very poorly.	beta-d-glucuronide	193-211	ATP binding cassette subfamily B member 1	Homo sapiens	39-43
11429411-1	2001	Murine multidrug resistance protein 1 (mrp1), differs from its human ortholog (MRP1) in that it fails to confer anthracycline resistance and transports the MRP1 substrate, 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG), very poorly.	beta-d-glucuronide	193-211	ATP binding cassette subfamily C member 1	Homo sapiens	79-83
10869290-0	2000	Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats.	beta-d-glucuronide	39-57	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
10556489-6	1999	The ATPase activity of reconstituted MRP1 was stimulated by the conjugated organic anion substrates leukotriene C(4) (LTC(4)) and 17beta-estradiol 17-(beta-D-glucuronide) with 50% maximal stimulation achieved at concentrations of 150 nM and 1.6 microM, respectively.	beta-d-glucuronide	151-169	ATP binding cassette subfamily C member 1	Homo sapiens	37-41
10217542-4	1999	Two MRP substrates, taurolithocholate-3-sulphate (TLCS) and beta-estradiol 17-(beta-D-glucuronide) (E217betaG) caused a voltage-dependent block of macroscopic CFTR Cl- currents when applied to the intracellular face of excised membrane patches, with mean apparent dissociation constants (KDs) of 96+/-10 and 563+/-103 microM (at 0 mV) respectively.	beta-d-glucuronide	79-97	ATP binding cassette subfamily C member 1	Homo sapiens	4-7
10217542-4	1999	Two MRP substrates, taurolithocholate-3-sulphate (TLCS) and beta-estradiol 17-(beta-D-glucuronide) (E217betaG) caused a voltage-dependent block of macroscopic CFTR Cl- currents when applied to the intracellular face of excised membrane patches, with mean apparent dissociation constants (KDs) of 96+/-10 and 563+/-103 microM (at 0 mV) respectively.	beta-d-glucuronide	79-97	CF transmembrane conductance regulator	Homo sapiens	159-163
8910374-10	1996	Transport of LTC4 by Sf21 membrane vesicles containing either intact or reconstituted MRP was competitively inhibited by both S-decylglutathione and 17beta-estradiol 17-(beta-D-glucuronide), with Ki values similar to those reported previously for MRP expressed in HeLa cells (Loe, D. W., Almquist, K. C., Deeley, R. G., and Cole, S. P. C. (1996) J. Biol.	beta-d-glucuronide	170-188	ATP binding cassette subfamily C member 1	Homo sapiens	86-89
8910374-10	1996	Transport of LTC4 by Sf21 membrane vesicles containing either intact or reconstituted MRP was competitively inhibited by both S-decylglutathione and 17beta-estradiol 17-(beta-D-glucuronide), with Ki values similar to those reported previously for MRP expressed in HeLa cells (Loe, D. W., Almquist, K. C., Deeley, R. G., and Cole, S. P. C. (1996) J. Biol.	beta-d-glucuronide	170-188	ATP binding cassette subfamily C member 1	Homo sapiens	247-250
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	beta-d-glucuronide	321-339	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-31
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	beta-d-glucuronide	321-339	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	33-36
9794924-0	1998	Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells.	beta-d-glucuronide	63-81	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	107-111
9794924-2	1998	Human MDR1-expressing multidrug-resistant cells display increased resistance to estradiol-17beta(beta-D-glucuronide) (E217G).	beta-d-glucuronide	97-115	ATP binding cassette subfamily B member 1	Homo sapiens	6-10
8779894-10	1996	In HeLa cell monolayers transfected with a full-length oatp cDNA, [3H]estradiol 17 beta-D-glucuronide ([3H]E2-17G) was transported with a signal-to-noise ratio of 15:1 over that of monolayers transfected with a control plasmid.	beta-d-glucuronide	83-101	solute carrier organic anion transporter family member 1A2	Homo sapiens	55-59
180808-1	1976	A rapid, direct radioimmunoassay for estriol-16alpha-(beta-D-glucuronide) in pregnancy urine has been developed by use of immunogens in which the estriol glucuronide hapten is linked through positions 2 or 4 of ring A to bovine serum albumin or agarose gel.	beta-d-glucuronide	54-72	albumin	Homo sapiens	228-241
32146834-6	2020	To demonstrate the functional effects of fecal enzymatic activity, we examined beta-glucuronidase-mediated cleavage of serotonin beta-d-glucuronide (5-HT-GLU) and the resultant production of free 5-HT by HPLC.	beta-d-glucuronide	129-147	glucuronidase, beta	Mus musculus	79-97
30910587-7	2019	MicroRNA-200a/-183 downregulated UGT1A9 expression in a dose-dependent manner and significantly reduced sorafenib beta-D-glucuronide formation in HCC cells.	beta-d-glucuronide	114-132	microRNA 200a	Homo sapiens	0-13