PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28710970-6	2017	Glucuronidase/sulfatase was added to plasma or urine spiked with 4-methylumbelliferyl-beta-d-glucuronide (MUG) and 4-methylumbelliferyl sulfate (MUS) and umbelliferone, which was used as the internal standard.	7-hydroxycoumarin	154-167	arylsulfatase family member H	Homo sapiens	14-23
28732810-3	2017	PURPOSE: In this study we investigated the modulating properties of four biologically active oxyprenylated ferulic acid and umbelliferone derivatives and of their unprenylated parent compounds on GLUT-4 mediated glucose uptake and translocation.	7-hydroxycoumarin	124-137	solute carrier family 2 member 4	Rattus norvegicus	196-202
28396694-3	2017	A uridine diphosphate glycosyltransferase YjiC from Bacillus licheniformis DSM 13, a cytochrome P450BM3 (CYP450 BM3) variant namely mutant 13 (M13) from Bacillus megaterium, and an O-methyltransferase from Streptomyces avermitilis (SaOMT2) were used for modifications of umbelliferone.	7-hydroxycoumarin	271-284	glycosyltransferase family 2 protein	Bacillus licheniformis DSM 13 = ATCC 14580	22-41
28868119-2	2017	MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method.	7-hydroxycoumarin	33-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	303-323
28868119-2	2017	MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method.	7-hydroxycoumarin	33-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	325-329
28868119-2	2017	MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method.	7-hydroxycoumarin	33-50	butyrylcholinesterase	Homo sapiens	335-356
28868119-2	2017	MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method.	7-hydroxycoumarin	33-50	butyrylcholinesterase	Homo sapiens	358-363
28011377-0	2017	Possible involvement of Nrf2 and PPARgamma up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity.	7-hydroxycoumarin	85-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-28
28011377-0	2017	Possible involvement of Nrf2 and PPARgamma up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity.	7-hydroxycoumarin	85-98	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	33-42
27815364-5	2017	CYP2A6 enzyme activity was determined through measurement of cotinine formation from nicotine and 7-hydroxycoumarin formation from coumarin.	7-hydroxycoumarin	98-115	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
27646771-0	2017	Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway.	7-hydroxycoumarin	0-13	AKT serine/threonine kinase 1	Rattus norvegicus	152-155
27646771-5	2017	Rats under CUMS stimulation treated with umbelliferone (15mg/kg, 30mg/kg) showed reduced neuronal apoptosis, as well as inhibited inflammatory cytokines levels by down-regulating Rho-associated protein kinase (ROCK) signaling and up-regulating protein kinase B (Akt) signaling.	7-hydroxycoumarin	41-54	AKT serine/threonine kinase 1	Rattus norvegicus	262-265
27646771-6	2017	In conclusion, umbelliferone showed neuroprotective effects on CUMS-induced model of depression, which was associated with the inhibition of neuronal apoptosis modulated by ROCK/Akt pathway.	7-hydroxycoumarin	15-28	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
26930228-0	2016	Activation of beta1-adrenoceptor triggers oxidative stress mediated myocardial membrane destabilization in isoproterenol induced myocardial infarcted rats: 7-hydroxycoumarin and its counter action.	7-hydroxycoumarin	156-173	adrenoceptor beta 1	Rattus norvegicus	14-32
27658793-0	2016	New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties.	7-hydroxycoumarin	68-85	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	51-56
27658793-3	2016	It was found that the 7-hydroxycoumarin derivatives with monoterpene pinene moiety are effective inhibitors of Tdp 1 with the most active derivative (+)-25c with IC50 value of 0.675muM.	7-hydroxycoumarin	22-39	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	111-116
27706905-0	2016	Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-kappaB pathway.	7-hydroxycoumarin	11-24	nuclear receptor interacting protein 1	Mus musculus	113-119
27706905-0	2016	Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-kappaB pathway.	7-hydroxycoumarin	11-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
27478031-7	2016	On the whole, the compounds presented here show some differences, with respect to previous studies in terms of SAR from similar Mannich bases of 7-hydroxycoumarin.	7-hydroxycoumarin	145-162	sarcosine dehydrogenase	Homo sapiens	111-114
27240190-0	2016	7-Hydroxycoumarin prevents UVB-induced activation of NF-kappaB and subsequent overexpression of matrix metalloproteinases and inflammatory markers in human dermal fibroblast cells.	7-hydroxycoumarin	0-17	nuclear factor kappa B subunit 1	Homo sapiens	53-62
27240190-4	2016	Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-kappaB thereby subsequently preventing the overexpression of TNF-alpha and IL-6 in HDFa cells.	7-hydroxycoumarin	22-39	nuclear factor kappa B subunit 1	Homo sapiens	83-92
27240190-4	2016	Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-kappaB thereby subsequently preventing the overexpression of TNF-alpha and IL-6 in HDFa cells.	7-hydroxycoumarin	22-39	tumor necrosis factor	Homo sapiens	147-156
27240190-4	2016	Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-kappaB thereby subsequently preventing the overexpression of TNF-alpha and IL-6 in HDFa cells.	7-hydroxycoumarin	22-39	interleukin 6	Homo sapiens	161-165
27241161-5	2016	The system was first tested using resting yeast cells coexpressing UGDH and human UGT1A6, 7-hydroxycoumarin as the substrate, in a reaction medium containing 8% glucose, serving as a source of UDP-glucuronic acid.	7-hydroxycoumarin	90-107	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	82-88
27027512-4	2016	The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3beta, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis.	7-hydroxycoumarin	140-143	glycogen synthase kinase 3 beta	Rattus norvegicus	77-107
27027512-4	2016	The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3beta, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis.	7-hydroxycoumarin	140-143	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
26965862-0	2016	7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer.	7-hydroxycoumarin	14-27	androgen receptor	Homo sapiens	43-60
25997538-7	2015	Analysis with Annexin V and PI staining revealed that umbelliferone induced apoptotic events in HepG2 cells in a concentration-dependant manner (0-50 microM).	7-hydroxycoumarin	54-67	annexin A5	Homo sapiens	14-23
25490949-5	2015	The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.	7-hydroxycoumarin	111-129	lysyl oxidase	Rattus norvegicus	26-29
26071904-0	2015	Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome.	7-hydroxycoumarin	0-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-94
26071904-0	2015	Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome.	7-hydroxycoumarin	0-13	thioredoxin interacting protein	Rattus norvegicus	122-127
26071904-0	2015	Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome.	7-hydroxycoumarin	0-13	NLR family, pyrin domain containing 3	Rattus norvegicus	128-133
26071904-7	2015	UMB treatment also suppressed NLRP3 inflammasome activation via reducing expression of Thiredoxin-interactive protein (TXNIP).	7-hydroxycoumarin	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	30-35
26071904-7	2015	UMB treatment also suppressed NLRP3 inflammasome activation via reducing expression of Thiredoxin-interactive protein (TXNIP).	7-hydroxycoumarin	0-3	thioredoxin interacting protein	Rattus norvegicus	87-117
26071904-7	2015	UMB treatment also suppressed NLRP3 inflammasome activation via reducing expression of Thiredoxin-interactive protein (TXNIP).	7-hydroxycoumarin	0-3	thioredoxin interacting protein	Rattus norvegicus	119-124
25557029-11	2015	Moreover, umbelliferone (from fr.9) and pentadecanoic acid could activate PPARgamma and PPARbeta at the same time.	7-hydroxycoumarin	10-23	peroxisome proliferator activated receptor delta	Homo sapiens	88-96
25557029-13	2015	Besides, umbelliferone and pentadecanoic acid isolated from the flower of E.gardneri were the new agonists for PPARgamma and PPARbeta.	7-hydroxycoumarin	9-22	peroxisome proliferator activated receptor delta	Homo sapiens	125-133
25329010-4	2014	The generation of ( )OHf was indirectly verified by using coumarin as an OH radical trapper and comparing the yields of coumarin--OH adduct (i.e., 7-hydroxycoumarin) formed in the absence and presence of As(V).	7-hydroxycoumarin	147-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	204-209
25170823-0	2014	Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.	7-hydroxycoumarin	0-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	95-138
25262573-0	2014	Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARalpha and SREBP-1c in rats.	7-hydroxycoumarin	8-21	peroxisome proliferator activated receptor alpha	Rattus norvegicus	79-88
25262573-0	2014	Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARalpha and SREBP-1c in rats.	7-hydroxycoumarin	8-21	sterol regulatory element binding transcription factor 1	Rattus norvegicus	93-101
25170823-0	2014	Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.	7-hydroxycoumarin	0-13	heme oxygenase 1	Rattus norvegicus	148-164
25170823-2	2014	The purpose of the present study was to investigate the protective effects of two coumarin derivatives, umbelliferone and daphnetin, against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats and elucidate the underlying mechanism.	7-hydroxycoumarin	104-117	C-C motif chemokine ligand 4	Rattus norvegicus	163-167
25170823-3	2014	Treatment of rats with either umbelliferone or daphnetin significantly improved the CCl4-induced biochemical alterations.	7-hydroxycoumarin	30-43	C-C motif chemokine ligand 4	Rattus norvegicus	84-88
25170823-6	2014	Finally, umbelliferone and daphnetin induced the nuclear translocation of the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), thereby inducing the expression and activity of the cytoprotective heme oxygenase-1 (HO-1).	7-hydroxycoumarin	9-22	nuclear factor, erythroid 2	Rattus norvegicus	78-104
25170823-6	2014	Finally, umbelliferone and daphnetin induced the nuclear translocation of the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), thereby inducing the expression and activity of the cytoprotective heme oxygenase-1 (HO-1).	7-hydroxycoumarin	9-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-129
25170823-6	2014	Finally, umbelliferone and daphnetin induced the nuclear translocation of the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), thereby inducing the expression and activity of the cytoprotective heme oxygenase-1 (HO-1).	7-hydroxycoumarin	9-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	131-135
25170823-6	2014	Finally, umbelliferone and daphnetin induced the nuclear translocation of the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), thereby inducing the expression and activity of the cytoprotective heme oxygenase-1 (HO-1).	7-hydroxycoumarin	9-22	heme oxygenase 1	Rattus norvegicus	205-221
25170823-6	2014	Finally, umbelliferone and daphnetin induced the nuclear translocation of the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), thereby inducing the expression and activity of the cytoprotective heme oxygenase-1 (HO-1).	7-hydroxycoumarin	9-22	heme oxygenase 1	Rattus norvegicus	223-227
25170823-7	2014	These results suggest that umbelliferone and daphnetin ameliorate oxidative stress-related hepatotoxicity via their ability to augment cellular antioxidant defenses by activating Nrf2-mediated HO-1 expression.	7-hydroxycoumarin	27-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	179-183
25170823-7	2014	These results suggest that umbelliferone and daphnetin ameliorate oxidative stress-related hepatotoxicity via their ability to augment cellular antioxidant defenses by activating Nrf2-mediated HO-1 expression.	7-hydroxycoumarin	27-40	heme oxygenase 1	Rattus norvegicus	193-197
23973822-4	2013	Particularly, 7-hydroxycoumarin analog 6h showed good antiproliferative activity against all tested cell lines (IC50 values<=5.5 muM).	7-hydroxycoumarin	14-31	latexin	Homo sapiens	132-135
24941128-0	2014	Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.	7-hydroxycoumarin	50-67	butyrylcholinesterase	Rattus norvegicus	19-33
24941128-1	2014	A series of 7-hydroxycoumarin derivatives connected by an amidic linker to the different amines were designed and synthesized as cholinesterase inhibitors.	7-hydroxycoumarin	12-29	butyrylcholinesterase	Rattus norvegicus	129-143
24495045-0	2014	Binding and molecular dynamics studies of 7-hydroxycoumarin derivatives with human serum albumin and its pharmacological importance.	7-hydroxycoumarin	42-59	albumin	Mus musculus	89-96
23994743-8	2013	Therefore, 7-hydroxycoumarin and the derivatives investigated here were able to modulate the effector functions of human neutrophils and scavenge reactive oxidizing species; they also generated reactive coumarin derivatives in the presence of myeloperoxidase.	7-hydroxycoumarin	11-28	myeloperoxidase	Homo sapiens	243-258
23184853-6	2013	Umbelliferone and esculetin also prevented MPTP-dependent caspase 3 activation, an indicator of apoptosis, but did not inhibit monoamine oxidase activity.	7-hydroxycoumarin	0-13	caspase 3	Mus musculus	58-67
23153282-0	2012	Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.	7-hydroxycoumarin	17-30	monoamine oxidase A	Homo sapiens	67-86
23182697-1	2013	New series of bioactive 7-oxycoumarin derivatives were synthesized and tested for their in vitro and in vivo monoamine oxidase (MAO) A and B inhibitory effect.	7-hydroxycoumarin	24-37	monoamine oxidase A	Homo sapiens	109-134
23153282-4	2012	The docking experiments carried out on MAO-A and MAO-B structures proved new information about the enzyme-inhibitor interaction and the potential therapeutic application of 7-oxycoumarin scaffold.	7-hydroxycoumarin	173-186	monoamine oxidase A	Homo sapiens	39-44
23153282-4	2012	The docking experiments carried out on MAO-A and MAO-B structures proved new information about the enzyme-inhibitor interaction and the potential therapeutic application of 7-oxycoumarin scaffold.	7-hydroxycoumarin	173-186	monoamine oxidase B	Homo sapiens	49-54
22822664-5	2012	RESULTS: TLC chromatogram of 13 samples had 8 well-resolved characteristic peaks, in which 4 peaks were falcarindiol, umbelliferone, scopoletin and isoimperatorin, respectively.	7-hydroxycoumarin	118-131	lipocalin 1	Homo sapiens	9-12
22964423-6	2012	The basis of the inducible protection by 7-hydroxycoumarin was shown to be associated with induction of the aldo-keto reductases AKR7A2 (1.5-fold) and AKR1C (3-fold), and this inducible protection was sufficient to overcome siRNA silencing of AKR1C3.	7-hydroxycoumarin	41-58	aldo-keto reductase family 7 member A2	Homo sapiens	129-135
22964423-6	2012	The basis of the inducible protection by 7-hydroxycoumarin was shown to be associated with induction of the aldo-keto reductases AKR7A2 (1.5-fold) and AKR1C (3-fold), and this inducible protection was sufficient to overcome siRNA silencing of AKR1C3.	7-hydroxycoumarin	41-58	aldo-keto reductase family 1 member C3	Homo sapiens	243-249
20074593-0	2010	Fluorogenic substrates for the screening assay of transketolase through beta-elimination of umbelliferone--Development, scope and limitations.	7-hydroxycoumarin	92-105	transketolase	Homo sapiens	50-63
21946110-6	2011	On the other hand, 124 muM umbelliferone treatment significantly decreased % of apoptotic cells and prevented radiation induced mitochondrial depolarization in lymphocytes.	7-hydroxycoumarin	27-40	latexin	Homo sapiens	23-26
21946110-8	2011	Conversely, umbelliferone (124 muM) treatment before irradiation decreased comet attributes and lipid peroxidative markers with improved antioxidant enzyme activities in irradiated lymphocytes.	7-hydroxycoumarin	12-25	latexin	Homo sapiens	31-34
21362475-4	2011	7-Benzyloxy-4-(trifluoromethyl)-coumarin (BFC) and 7-hydroxycoumarin (7-HC) were used as fluorescent substrates in order to determine CYP3A4 and CYP2A6 catalytic activity, respectively.	7-hydroxycoumarin	51-68	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	145-151
20534555-4	2010	Through structure-guided mutagenesis, we created a mutant ligase capable of recognizing a 7-hydroxycoumarin substrate and catalyzing its covalent conjugation to a transposable 13-amino acid peptide called LAP (LplA Acceptor Peptide).	7-hydroxycoumarin	90-107	LAP	Homo sapiens	205-208
20534555-4	2010	Through structure-guided mutagenesis, we created a mutant ligase capable of recognizing a 7-hydroxycoumarin substrate and catalyzing its covalent conjugation to a transposable 13-amino acid peptide called LAP (LplA Acceptor Peptide).	7-hydroxycoumarin	90-107	LAP	Homo sapiens	210-231
19470355-0	2009	Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom.	7-hydroxycoumarin	10-23	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	137-142
19913056-1	2010	We previously demonstrated that 7-hydroxycoumarin (7HC) was effective in reducing proinflammatory cytokine production in lipopolysaccharide-exposed macrophage-like P388D1 cells and fever production by suppressing the increase in interleukin (IL)-1alpha production in an influenza virus-intranasal infection model in mice.	7-hydroxycoumarin	32-49	interleukin 1 alpha	Mus musculus	229-252
19913056-1	2010	We previously demonstrated that 7-hydroxycoumarin (7HC) was effective in reducing proinflammatory cytokine production in lipopolysaccharide-exposed macrophage-like P388D1 cells and fever production by suppressing the increase in interleukin (IL)-1alpha production in an influenza virus-intranasal infection model in mice.	7-hydroxycoumarin	51-54	interleukin 1 alpha	Mus musculus	229-252
19289114-5	2009	A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with umbelliferone, similar to that observed with dexamethasone.	7-hydroxycoumarin	124-137	interleukin 4	Mus musculus	15-19
19289114-5	2009	A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with umbelliferone, similar to that observed with dexamethasone.	7-hydroxycoumarin	124-137	interleukin 5	Mus musculus	21-25
19289114-5	2009	A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with umbelliferone, similar to that observed with dexamethasone.	7-hydroxycoumarin	124-137	interleukin 13	Mus musculus	31-36
19470355-0	2009	Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom.	7-hydroxycoumarin	25-42	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	137-142
19470355-4	2009	The present study describes the interaction between umbelliferone (7-HOC) and the sPLA2 from Crotalus durissus collilineatus venom.	7-hydroxycoumarin	52-65	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	82-87
16329506-1	2005	The interaction between bovine serum albumin (BSA) a nd umbelliferone, an active component of Chinese herbs, with or without metal ions was investigated using fluorescence spectroscopy (FS) and UV.	7-hydroxycoumarin	56-69	albumin	Homo sapiens	31-44
18840518-1	2008	Coumarin is bioactivated via 3,4-epoxidation resulting in formation of the hepatotoxic o-hydroxyphenylacetaldehyde (oHPA) and detoxified by cytochrome P450 2A6 (CYP2A6) hydroxylation leading to 7-hydroxycoumarin.	7-hydroxycoumarin	194-211	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	161-167
18642865-4	2008	Fluorogenic caspase-3 substrates 11 and 13 derived from umbelliferone and DAO, respectively, were prepared.	7-hydroxycoumarin	56-69	caspase 3	Homo sapiens	12-21
18452392-3	2008	MAGL protein catalyzes the hydrolysis of 7-HCA to generate arachidonic acid and the highly fluorescent 7-hydroxyl coumarin (7-HC).	7-hydroxycoumarin	103-122	monoglyceride lipase	Homo sapiens	0-4
18452392-3	2008	MAGL protein catalyzes the hydrolysis of 7-HCA to generate arachidonic acid and the highly fluorescent 7-hydroxyl coumarin (7-HC).	7-hydroxycoumarin	41-45	monoglyceride lipase	Homo sapiens	0-4
17219461-2	2007	The aliphatic primary alcohol-leaving group released the fluorescent product umbelliferone by an enolization/beta-elimination reaction similar to the triose phosphate isomerase (TIM) reaction.	7-hydroxycoumarin	77-90	triosephosphate isomerase 1	Homo sapiens	150-176
17219461-2	2007	The aliphatic primary alcohol-leaving group released the fluorescent product umbelliferone by an enolization/beta-elimination reaction similar to the triose phosphate isomerase (TIM) reaction.	7-hydroxycoumarin	77-90	triosephosphate isomerase 1	Homo sapiens	178-181
16289009-2	2005	The progress of the TGase-catalyzed reaction of 4-(N-carbobenzoxy-l-phenylalanylamino)-butyric acid coumarin-7-yl ester was monitored as an increase of fluorescence (lambda(exc) 330 nm, lambda(em) 460 nm) due to the release of 7-hydroxycoumarin.	7-hydroxycoumarin	227-244	coagulation factor XIII A chain	Homo sapiens	20-25
15041069-6	2004	In addition, urine Cd excretion of men and women showed a positive correlation (r = 0.46 to 0.54, P < 0.001) with urine 7-hydroxycoumarin (7-OHC) excretion which was used as a marker of liver cytochrome P450 2A6 (CYP2A6) enzyme activity.	7-hydroxycoumarin	123-140	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	195-214
15041069-6	2004	In addition, urine Cd excretion of men and women showed a positive correlation (r = 0.46 to 0.54, P < 0.001) with urine 7-hydroxycoumarin (7-OHC) excretion which was used as a marker of liver cytochrome P450 2A6 (CYP2A6) enzyme activity.	7-hydroxycoumarin	123-140	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	216-222
15579072-8	2004	A recent study has shown that 7-hydroxycoumarin inhibits the release of Cyclin D1, which is overexpressed in many types of cancer.	7-hydroxycoumarin	30-47	cyclin D1	Homo sapiens	72-81
15044611-7	2004	UGT1A9Sol exhibited a relatively high rate of scopoletin glucuronidation, whereas its activity toward 1-naphthol, entacapone, umbelliferone, and 4-nitrophenol was much lower.	7-hydroxycoumarin	126-139	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	0-6
14738594-1	2003	CYP2A6 metabolizes coumarin to 7-hydroxycoumarin showing fluorescence, as measured by fluorometry.	7-hydroxycoumarin	31-48	cytochrome P450 2A13	Bos taurus	0-6
12758156-0	2003	Spectrofluorimetric analysis of 7-hydroxycoumarin binding to bovine phenol sulfotransferase.	7-hydroxycoumarin	32-49	sulfotransferase 1A1	Bos taurus	68-91
12758156-2	2003	Previous work with the bovine SULT1A1 has utilized the highly fluorescent substrate 7-hydroxycoumarin (7-HC, umbelliferone) as an acceptor substrate [Biochem.	7-hydroxycoumarin	84-101	sulfotransferase 1A1	Bos taurus	30-37
12758156-2	2003	Previous work with the bovine SULT1A1 has utilized the highly fluorescent substrate 7-hydroxycoumarin (7-HC, umbelliferone) as an acceptor substrate [Biochem.	7-hydroxycoumarin	103-107	sulfotransferase 1A1	Bos taurus	30-37
12758156-2	2003	Previous work with the bovine SULT1A1 has utilized the highly fluorescent substrate 7-hydroxycoumarin (7-HC, umbelliferone) as an acceptor substrate [Biochem.	7-hydroxycoumarin	109-122	sulfotransferase 1A1	Bos taurus	30-37
12708602-1	2003	OBJECTIVE: Coumarin, used in the treatment of chronic venous diseases, is mainly metabolized to non-toxic 7-hydroxy-coumarin by CYP2A6.	7-hydroxycoumarin	106-124	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	128-134
11566023-5	2001	Four 7-butoxycoumarin metabolites were produced by CYP2B1, of which two, 7-hydroxycoumarin and 7-(3-hydroxybutoxy)coumarin, were formed at nearly equal rates.	7-hydroxycoumarin	71-90	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	51-57
12388221-5	2003	Confirmation of the effects of these serum glucose manipulations on brain intracellular pH (pH(i)) was confirmed in a group of acute experiments utilizing umbelliferone fluorescence.	7-hydroxycoumarin	155-168	glucose-6-phosphate isomerase	Rattus norvegicus	92-97
12185557-3	2002	Cytochrome P450 (CYP) 2A6 activity was measured using the ratio of urinary 7-hydroxycoumarin (7-OHC) excreted in 8 h after a coumarin dose.	7-hydroxycoumarin	75-92	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-25
12420755-1	2002	The 7-hydroxycoumarins, umbelliferone and 4-methylumbelliferone (IC50 = 1.4 and 1.9 microM, respectively) were potent inhibitors of human testes microsomal 17beta-HSD (type 3) enzyme whereas 7-methoxycoumarin, 4-hydroxycoumarin and 7-ethoxycoumarin had little or no inhibitory activity.	7-hydroxycoumarin	24-37	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	156-166
11679177-0	2001	Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin.	7-hydroxycoumarin	74-91	cyclin D1	Homo sapiens	12-21
11679177-12	2001	In contrast, cyclin D1 significantly decreased, which appears to indicate an action of 7-hydroxycoumarin in early events of phase G(1).	7-hydroxycoumarin	87-104	cyclin D1	Homo sapiens	13-22
11679177-17	2001	Knowledge of the decrease of cyclin D1 by 7-hydroxycoumarin may lead to its use in cancer therapy, as well as to the development of more active compounds.	7-hydroxycoumarin	42-59	cyclin D1	Homo sapiens	29-38
10781881-2	2000	CYP2A6 is the only enzyme catalysing this reaction and consequently the formation of 7-hydroxycoumarin can be used as "an in vitro and in vivo probe" for CYP2A6.	7-hydroxycoumarin	85-102	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
10781881-2	2000	CYP2A6 is the only enzyme catalysing this reaction and consequently the formation of 7-hydroxycoumarin can be used as "an in vitro and in vivo probe" for CYP2A6.	7-hydroxycoumarin	85-102	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	154-160
10620357-1	2000	The oxidation of a series of seven alkyl ethers of 7-hydroxycoumarin by cytochrome P450 3A4 (CYP3A4) has been studied to probe the active site of the enzyme.	7-hydroxycoumarin	51-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-91
10620357-1	2000	The oxidation of a series of seven alkyl ethers of 7-hydroxycoumarin by cytochrome P450 3A4 (CYP3A4) has been studied to probe the active site of the enzyme.	7-hydroxycoumarin	51-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
10376771-4	1999	However, in females, there was a major strain difference in the degree of metabolism to coumarin 7-hydroxylase with DBA/2 and 129 having high 7-hydroxycoumarin formation, CBA/Ca having intermediate levels and the other strains low levels.	7-hydroxycoumarin	142-159	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	88-110
9409631-4	1997	His immediate family members, who were heterozygous for the CYP2A6*2 allele, excreted little 2-hydroxyphenylacetic acid and mainly 7-hydroxycoumarin, when similarly tested.	7-hydroxycoumarin	131-148	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	60-66
9918546-8	1999	Purified, heterologously expressed mouse CYP2A5 and CYP2G1 produced 7-hydroxycoumarin and o-HPA as the predominant products, respectively.	7-hydroxycoumarin	68-85	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	41-47
9918546-8	1999	Purified, heterologously expressed mouse CYP2A5 and CYP2G1 produced 7-hydroxycoumarin and o-HPA as the predominant products, respectively.	7-hydroxycoumarin	68-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Mus musculus	52-58
9871718-2	1998	Their oxidation forms ketone 2, which undergoes beta-elimination of umbelliferone under catalysis by bovine serum albumin, leading to a > 20-fold fluorescence increase at lambda em = 460 +/- 20 nm (lambda ex = 360 +/- 20 nm).	7-hydroxycoumarin	68-81	albumin	Homo sapiens	108-121
9355936-2	1997	In this study, the 7-hydroxycoumarin (7OHC) excretion test used in vivo as a bioindex of hepatic CYP2A6 activity was performed in 20, previously healthy, acute jaundice HVA patients.	7-hydroxycoumarin	19-36	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	97-103
9115999-2	1997	It is shown that human cytosolic 85 kDa phospholipase A2 (cPLA2) hydrolyzes sn-2-arachidonyl-containing phospholipids or the gamma-linolenoyl ester of 7-hydroxycoumarin (GLU) dispersed in vesicles of 1,2-dioleoyl-sn-glycero-3-phosphomethanol (L-DOPM) in the scooting mode.	7-hydroxycoumarin	151-168	phospholipase A2 group IVA	Homo sapiens	58-63
9373993-3	1997	Binding spectra of the ligand umbelliferone with the CYP2B1:NADPH-cytochrome P450 reductase-complex were determined by difference spectroscopy.	7-hydroxycoumarin	30-43	cytochrome p450 oxidoreductase	Homo sapiens	60-91
9373993-7	1997	The excitation energy transfer from the donor umbelliferone (lambda E = 380 nm; lambda F = 460 nm) to the acceptor molecule FMN (lambda E = 465 nm; lambda F = 525 nm) was examined under assay conditions.	7-hydroxycoumarin	46-59	formin 1	Homo sapiens	124-127
9022707-8	1996	The S. aureus lipase has a narrow substrate specificity: short-chain triacylglycerols and acyl esters of both p-nitrophenol and umbelliferone are readily degraded, whereas medium- and long-chain lipids, as well as phospholipids, are poor substrates.	7-hydroxycoumarin	128-141	lipase	Staphylococcus aureus	14-20
8896890-2	1996	Coumarin hydroxylase activity of CYP 2A6 was assessed by administering a probe drug, coumarin, and measuring its metabolite, 7-hydroxycoumarin, in urines collected between 0-2 h and 2-4 h of 106 people with varying intensities of Opisthorchis viverrini infection.	7-hydroxycoumarin	125-142	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	33-40
8896890-6	1996	Reassessments of coumarin hydroxylase activity of CYP 2A6 made 2 months after praziquantel treatment showed highly significant reductions in the amount of 7-hydroxycoumarin excreted among the infected groups but no difference in the uninfected group.	7-hydroxycoumarin	155-172	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	50-57
7726643-8	1995	In addition to cytochrome P450-mediated monooxygenases, there was significant induction of the Phase II drug-metabolizing enzymes, DT-diaphorase, glutathione S-transferase activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and UDP-glucuronyltransferase activities towards 4-nitrophenol and 7-hydroxycoumarin.	7-hydroxycoumarin	319-336	hematopoietic prostaglandin D synthase	Rattus norvegicus	146-171
8641823-5	1996	Cytochrome P-450 activity was determined at 4 and 24 hours by measuring the formation of 7-hydroxycoumarine (7-HC) from 7-ethoxycoumarine (7-EC).	7-hydroxycoumarin	89-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
8641823-5	1996	Cytochrome P-450 activity was determined at 4 and 24 hours by measuring the formation of 7-hydroxycoumarine (7-HC) from 7-ethoxycoumarine (7-EC).	7-hydroxycoumarin	109-113	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	7-hydroxycoumarin	0-17	HRas proto-oncogene, GTPase	Homo sapiens	65-71
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	7-hydroxycoumarin	0-17	H3 histone pseudogene 16	Homo sapiens	65-68
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	7-hydroxycoumarin	174-191	HRas proto-oncogene, GTPase	Homo sapiens	65-71
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	7-hydroxycoumarin	174-191	H3 histone pseudogene 16	Homo sapiens	65-68
8600835-7	1995	The ester formed between gamma-linolenic acid and 7-hydroxycoumarin is also a substrate for cPLA2, and when incorporated into vesicles of the anionic phospholipid, 1,2-dioleoyl-sn-glycero-3-phosphomethanol, provides an assay in which the enzyme does not leave the vesicle surface (scooting mode).	7-hydroxycoumarin	50-67	phospholipase A2 group IVA	Homo sapiens	92-97
7756103-2	1995	The in vitro hepatic metabolism of lignocaine to monoethylglycinexylide (MEGX) is mediated by CYP3A4 and that of coumarin to 7-hydroxycoumarin (7OHC) by CYP2A6.	7-hydroxycoumarin	125-142	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	153-159
7953469-10	1994	Of the Phase II drug-metabolizing enzymes, DT-diaphorase and glutathione S-transferase (GST) activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and those of UDP-glucuronyltransferase (UGT) towards 4-nitrophenol and 7-hydroxycoumarin were increased from 2.7 to 1.4-fold by 1,2,4-TrCDD.	7-hydroxycoumarin	244-261	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	43-56
7856835-2	1994	Recombinant cPLA2 efficiently hydrolyzes fatty acid esters of 7-hydroxycoumarin, producing the free fatty acid and the highly fluorescent 7-hydroxycoumarin.	7-hydroxycoumarin	62-79	phospholipase A2 group IVA	Homo sapiens	12-17
7856835-2	1994	Recombinant cPLA2 efficiently hydrolyzes fatty acid esters of 7-hydroxycoumarin, producing the free fatty acid and the highly fluorescent 7-hydroxycoumarin.	7-hydroxycoumarin	138-155	phospholipase A2 group IVA	Homo sapiens	12-17
7953469-10	1994	Of the Phase II drug-metabolizing enzymes, DT-diaphorase and glutathione S-transferase (GST) activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and those of UDP-glucuronyltransferase (UGT) towards 4-nitrophenol and 7-hydroxycoumarin were increased from 2.7 to 1.4-fold by 1,2,4-TrCDD.	7-hydroxycoumarin	244-261	hematopoietic prostaglandin D synthase	Rattus norvegicus	61-86
7953469-10	1994	Of the Phase II drug-metabolizing enzymes, DT-diaphorase and glutathione S-transferase (GST) activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and those of UDP-glucuronyltransferase (UGT) towards 4-nitrophenol and 7-hydroxycoumarin were increased from 2.7 to 1.4-fold by 1,2,4-TrCDD.	7-hydroxycoumarin	244-261	hematopoietic prostaglandin D synthase	Rattus norvegicus	88-91
1323288-0	1992	ABA-induced "lipid melting" and its reversal by umbelliferone in the plasmalemma of guard cell protoplasts: a breakthrough in plant hormone-receptor binding and hormone action.	7-hydroxycoumarin	48-61	nuclear receptor subfamily 4 group A member 1	Homo sapiens	132-148
8132699-1	1994	7-Hydroxycoumarin (7-HC) was chemically conjugated by diazo coupling to carrier proteins such as bovine serum albumin (BSA), thyroglobulin and ovalbumin.	7-hydroxycoumarin	0-17	thyroglobulin	Homo sapiens	104-152
8132699-1	1994	7-Hydroxycoumarin (7-HC) was chemically conjugated by diazo coupling to carrier proteins such as bovine serum albumin (BSA), thyroglobulin and ovalbumin.	7-hydroxycoumarin	19-23	thyroglobulin	Homo sapiens	104-152
7510710-8	1994	In a similar fashion, coumarin and 7-HC inhibited the intracellular production of prostate-specific antigen by LNCaP cells.	7-hydroxycoumarin	35-39	kallikrein related peptidase 3	Homo sapiens	82-107
26640551-0	2015	Single-cell microinjection assay indicates that 7-hydroxycoumarin induces rapid activation of caspase-3 in A549 cancer cells.	7-hydroxycoumarin	48-65	caspase 3	Homo sapiens	94-103
1964228-4	1990	To prove this hypothesis, we determined the beta-glucuronidase plasma levels of 99 unselected patients suffering from various liver disorders in comparison with 19 healthy controls by use of the umbelliferone technique.	7-hydroxycoumarin	195-208	glucuronidase beta	Homo sapiens	44-62
26640551-2	2015	The aim of the present study was to determine whether 7-hydroxycoumarin (7-HC) induces changes in caspase-3 (C-3) activity in A549 human lung carcinoma cells.	7-hydroxycoumarin	54-71	complement C3	Homo sapiens	98-112
26640551-2	2015	The aim of the present study was to determine whether 7-hydroxycoumarin (7-HC) induces changes in caspase-3 (C-3) activity in A549 human lung carcinoma cells.	7-hydroxycoumarin	73-77	complement C3	Homo sapiens	98-112
26640551-4	2015	A 24-h exposure to 1.85 mM 7-HC induced a 65% increase in C-3 activity, and a notable conversion of procaspase-3 to C-3, in addition to poly(ADP-ribose)polymerase cleavage.	7-hydroxycoumarin	27-31	caspase 3	Homo sapiens	58-61
26640551-4	2015	A 24-h exposure to 1.85 mM 7-HC induced a 65% increase in C-3 activity, and a notable conversion of procaspase-3 to C-3, in addition to poly(ADP-ribose)polymerase cleavage.	7-hydroxycoumarin	27-31	caspase 3	Homo sapiens	116-119
26640551-4	2015	A 24-h exposure to 1.85 mM 7-HC induced a 65% increase in C-3 activity, and a notable conversion of procaspase-3 to C-3, in addition to poly(ADP-ribose)polymerase cleavage.	7-hydroxycoumarin	27-31	poly(ADP-ribose) polymerase 1	Homo sapiens	136-162
34752968-0	2022	7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/beta-catenin signaling pathway.	7-hydroxycoumarin	0-17	Wnt family member 1	Rattus norvegicus	181-184
34979142-11	2022	Scopoletin and umbelliferone decreased palmitate- and GCDCA-induced expression of ER stress markers, phosphorylation of the cell death signaling intermediate JNK as well as ROS production.	7-hydroxycoumarin	15-28	mitogen-activated protein kinase 8	Homo sapiens	158-161
34979142-12	2022	CONCLUSION: Scopoletin and umbelliferone protect against palmitate and bile acid-induced cell death of hepatocytes by inhibition of ER stress and ROS generation and decreasing phosphorylation of JNK.	7-hydroxycoumarin	27-40	mitogen-activated protein kinase 8	Homo sapiens	195-198
34752968-0	2022	7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/beta-catenin signaling pathway.	7-hydroxycoumarin	0-17	catenin beta 1	Rattus norvegicus	185-197
34752968-9	2022	RESULTS: 7-HC attenuated the severity of rat CIA, evidenced by the reduction of paw swelling, arthritis index, joint damage, collagen type II antibody serum level, and IL-1beta, IL-6, TNF-alpha production in serum and synovium.	7-hydroxycoumarin	9-13	interleukin 1 alpha	Rattus norvegicus	168-176
34752968-9	2022	RESULTS: 7-HC attenuated the severity of rat CIA, evidenced by the reduction of paw swelling, arthritis index, joint damage, collagen type II antibody serum level, and IL-1beta, IL-6, TNF-alpha production in serum and synovium.	7-hydroxycoumarin	9-13	interleukin 6	Rattus norvegicus	178-182
34752968-9	2022	RESULTS: 7-HC attenuated the severity of rat CIA, evidenced by the reduction of paw swelling, arthritis index, joint damage, collagen type II antibody serum level, and IL-1beta, IL-6, TNF-alpha production in serum and synovium.	7-hydroxycoumarin	9-13	tumor necrosis factor	Rattus norvegicus	184-193
34752968-11	2022	Further, 7-HC in vitro suppressed proliferation and promoted apoptosis of TNF-alpha-stimulated MH7A cells by regulating the mitochondrial pathway.	7-hydroxycoumarin	9-13	tumor necrosis factor	Homo sapiens	74-83
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	Wnt family member 1	Rattus norvegicus	42-45
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	catenin beta 1	Homo sapiens	46-58
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	Wnt family member 1	Rattus norvegicus	129-133
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	LDL receptor related protein 6	Rattus norvegicus	135-139
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	glycogen synthase kinase 3 alpha	Rattus norvegicus	143-152
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	catenin beta 1	Homo sapiens	161-173
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	cyclin D1	Rattus norvegicus	175-184
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	189-194
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	glycogen synthase kinase 3 alpha	Rattus norvegicus	213-222
34752968-12	2022	Mechanistically, 7-HC treatment inhibited Wnt/beta-catenin pathway, suggested by the reduction of pathway-related proteins (e.g. Wnt1, LRP6, p-GSK-3beta (Ser9), beta-catenin, cyclin D1 and c-Myc), the recovery of GSK-3beta activity and the inhibition of beta-catenin nuclear translocation.	7-hydroxycoumarin	17-21	catenin beta 1	Homo sapiens	254-266
34752968-13	2022	As expected, combined use of lithium chloride, an activator of Wnt/beta-catenin signaling, reversed the anti-proliferative and pro-apoptotic effects of 7-HC in vitro.	7-hydroxycoumarin	152-156	Wnt family member 1	Rattus norvegicus	63-66
34752968-13	2022	As expected, combined use of lithium chloride, an activator of Wnt/beta-catenin signaling, reversed the anti-proliferative and pro-apoptotic effects of 7-HC in vitro.	7-hydroxycoumarin	152-156	catenin beta 1	Homo sapiens	67-79
34752968-14	2022	CONCLUSION: 7-HC relieved the severity of rat CIA by inhibiting cell proliferation and inducing apoptosis of rheumatoid FLS via inhibition of Wnt/beta-catenin pathway.	7-hydroxycoumarin	12-16	Wnt family member 1	Rattus norvegicus	142-145
34752968-14	2022	CONCLUSION: 7-HC relieved the severity of rat CIA by inhibiting cell proliferation and inducing apoptosis of rheumatoid FLS via inhibition of Wnt/beta-catenin pathway.	7-hydroxycoumarin	12-16	catenin beta 1	Rattus norvegicus	146-158
34452623-0	2021	Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice.	7-hydroxycoumarin	28-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
34258700-4	2021	With regard to MTX, the results of this investigation reveal potent amelioration of MTX hepatotoxicity by BBR and UMB through reduction of the elevated serum levels of ALT, ALP, AST, and LDH confirmed by the attenuation of histopathological abrasion in liver tissues.	7-hydroxycoumarin	114-117	ATHS	Homo sapiens	173-176
34258700-4	2021	With regard to MTX, the results of this investigation reveal potent amelioration of MTX hepatotoxicity by BBR and UMB through reduction of the elevated serum levels of ALT, ALP, AST, and LDH confirmed by the attenuation of histopathological abrasion in liver tissues.	7-hydroxycoumarin	114-117	solute carrier family 17 member 5	Homo sapiens	178-181
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	mitogen-activated protein kinase 14	Homo sapiens	133-140
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	nuclear factor kappa B subunit 1	Homo sapiens	142-151
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	kelch like ECH associated protein 1	Homo sapiens	157-163
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	kelch like ECH associated protein 1	Homo sapiens	207-213
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	mitogen-activated protein kinase 14	Homo sapiens	215-222
34258700-7	2021	Interestingly, in silico studies via molecular docking pinpointed the binding modes of BBR and UMB to the binding pocket residues of P38MAPK, NF-kappaB, and Keap-1 and demonstrated a promising inhibition of Keap-1, P38MAPK, and NF-kappaB.	7-hydroxycoumarin	95-98	nuclear factor kappa B subunit 1	Homo sapiens	228-237
34258700-8	2021	BBR and UMB reduced the expression of pro-apoptotic protein Bax and apoptotic protein caspase-3 as well as increased the expression of anti-apoptotic protein Bcl-2.	7-hydroxycoumarin	8-11	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
34258700-8	2021	BBR and UMB reduced the expression of pro-apoptotic protein Bax and apoptotic protein caspase-3 as well as increased the expression of anti-apoptotic protein Bcl-2.	7-hydroxycoumarin	8-11	caspase 3	Homo sapiens	86-95
34258700-8	2021	BBR and UMB reduced the expression of pro-apoptotic protein Bax and apoptotic protein caspase-3 as well as increased the expression of anti-apoptotic protein Bcl-2.	7-hydroxycoumarin	8-11	BCL2 apoptosis regulator	Homo sapiens	158-163
34268687-0	2021	Umbelliferone alleviates hepatic ischemia/reperfusion-induced oxidative stress injury via targeting Keap-1/Nrf-2/ARE and TLR4/NF-kappaB-p65 signaling pathway.	7-hydroxycoumarin	0-13	Kelch-like ECH-associated protein 1	Rattus norvegicus	100-106
34268687-0	2021	Umbelliferone alleviates hepatic ischemia/reperfusion-induced oxidative stress injury via targeting Keap-1/Nrf-2/ARE and TLR4/NF-kappaB-p65 signaling pathway.	7-hydroxycoumarin	0-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-112
34268687-0	2021	Umbelliferone alleviates hepatic ischemia/reperfusion-induced oxidative stress injury via targeting Keap-1/Nrf-2/ARE and TLR4/NF-kappaB-p65 signaling pathway.	7-hydroxycoumarin	0-13	toll-like receptor 4	Rattus norvegicus	121-125
34268687-0	2021	Umbelliferone alleviates hepatic ischemia/reperfusion-induced oxidative stress injury via targeting Keap-1/Nrf-2/ARE and TLR4/NF-kappaB-p65 signaling pathway.	7-hydroxycoumarin	0-13	synaptotagmin 1	Rattus norvegicus	136-139
34268687-4	2021	Here, this study was conducted to examine the potential protective role of UMB during the early phase of hepatic IR injury via targeting Keap-1/Nrf-2/ARE and its closely related signaling pathway, TLR4/NF-kappaB-p65.	7-hydroxycoumarin	75-78	Kelch-like ECH-associated protein 1	Rattus norvegicus	137-143
34268687-4	2021	Here, this study was conducted to examine the potential protective role of UMB during the early phase of hepatic IR injury via targeting Keap-1/Nrf-2/ARE and its closely related signaling pathway, TLR4/NF-kappaB-p65.	7-hydroxycoumarin	75-78	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-149
34268687-4	2021	Here, this study was conducted to examine the potential protective role of UMB during the early phase of hepatic IR injury via targeting Keap-1/Nrf-2/ARE and its closely related signaling pathway, TLR4/NF-kappaB-p65.	7-hydroxycoumarin	75-78	toll-like receptor 4	Rattus norvegicus	197-201
34268687-4	2021	Here, this study was conducted to examine the potential protective role of UMB during the early phase of hepatic IR injury via targeting Keap-1/Nrf-2/ARE and its closely related signaling pathway, TLR4/NF-kappaB-p65.	7-hydroxycoumarin	75-78	synaptotagmin 1	Rattus norvegicus	212-215
34268687-7	2021	Our results revealed that oral UMB effectively reduced the serum levels of ALT, AST, ALP, and LDH along with the restoration of oxidant/antioxidant status.	7-hydroxycoumarin	31-34	PDZ and LIM domain 3	Rattus norvegicus	85-88
34268687-9	2021	Besides, UMB significantly down-regulated NF-kappaB-p65 and TLR4 expressions with subsequent decreased TNF-alpha and IL-1beta levels coupled with the up-regulation of the IL-10 level.	7-hydroxycoumarin	9-12	toll-like receptor 4	Rattus norvegicus	60-64
34268687-9	2021	Besides, UMB significantly down-regulated NF-kappaB-p65 and TLR4 expressions with subsequent decreased TNF-alpha and IL-1beta levels coupled with the up-regulation of the IL-10 level.	7-hydroxycoumarin	9-12	tumor necrosis factor	Rattus norvegicus	103-112
34268687-9	2021	Besides, UMB significantly down-regulated NF-kappaB-p65 and TLR4 expressions with subsequent decreased TNF-alpha and IL-1beta levels coupled with the up-regulation of the IL-10 level.	7-hydroxycoumarin	9-12	interleukin 1 alpha	Rattus norvegicus	117-125
34268687-9	2021	Besides, UMB significantly down-regulated NF-kappaB-p65 and TLR4 expressions with subsequent decreased TNF-alpha and IL-1beta levels coupled with the up-regulation of the IL-10 level.	7-hydroxycoumarin	9-12	interleukin 10	Rattus norvegicus	171-176
34268687-11	2021	Together, UMB is a promising agent for the amelioration of liver tissues against IR-induced oxidative injury through activation of the Keap-1/Nrf-2/ARE signaling pathway along with suppression of its closely related signaling pathways: TLR4/NF-kappaB-p65.	7-hydroxycoumarin	10-13	Kelch-like ECH-associated protein 1	Rattus norvegicus	135-141
34268687-11	2021	Together, UMB is a promising agent for the amelioration of liver tissues against IR-induced oxidative injury through activation of the Keap-1/Nrf-2/ARE signaling pathway along with suppression of its closely related signaling pathways: TLR4/NF-kappaB-p65.	7-hydroxycoumarin	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-147
34268687-11	2021	Together, UMB is a promising agent for the amelioration of liver tissues against IR-induced oxidative injury through activation of the Keap-1/Nrf-2/ARE signaling pathway along with suppression of its closely related signaling pathways: TLR4/NF-kappaB-p65.	7-hydroxycoumarin	10-13	toll-like receptor 4	Rattus norvegicus	236-240
34409680-0	2021	Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator-activated receptor-gamma agonism in rats.	7-hydroxycoumarin	0-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-132
34409680-9	2021	Pretreatment with bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) antagonist, attenuated umbelliferone-mediated protection.	7-hydroxycoumarin	135-148	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	50-98
34409680-9	2021	Pretreatment with bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) antagonist, attenuated umbelliferone-mediated protection.	7-hydroxycoumarin	135-148	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	100-110
34409680-10	2021	It is concluded that umbelliferone attenuates glycerol-induced AKI possibly through PPAR-gamma agonism in rats.	7-hydroxycoumarin	21-34	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-94
34583226-5	2021	We found that the phytochemical compounds, such as curcumin, naringenin, sulforaphane, diallyl disulfide, mangiferin, oleanolic acid, umbelliferone, daphnetin, quercetin, isorhamnetin-3-O-galactoside, hesperidin, diammonium glycyrrhizinate, corilagin, shikonin, farrerol, and chenpi, had the potential to improve the Nrf2-ARE signaling thereby combat hepatotoxicity.	7-hydroxycoumarin	134-147	NFE2 like bZIP transcription factor 2	Homo sapiens	317-321
34616738-10	2021	From the gene expression and PCR results, the final UMB-loaded composite induced osteogenic markers, such as Runx, OCN, and VEFG.	7-hydroxycoumarin	52-55	bone gamma-carboxyglutamate protein	Homo sapiens	115-118
34452623-0	2021	Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice.	7-hydroxycoumarin	28-41	nitric oxide synthase 2, inducible	Mus musculus	117-121
34452623-13	2021	The UMB administration induced the Nrf2 expression, while attenuated the iNOS expression.	7-hydroxycoumarin	4-7	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
34452623-13	2021	The UMB administration induced the Nrf2 expression, while attenuated the iNOS expression.	7-hydroxycoumarin	4-7	nitric oxide synthase 2, inducible	Mus musculus	73-77
34156072-0	2022	Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats.	7-hydroxycoumarin	0-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	107-155
34445725-5	2021	UMB treatment not only inhibited androgen/androgen receptor (AR) signaling-related markers, but also downregulated the overexpression of G1/S phase cell cycle-related markers.	7-hydroxycoumarin	0-3	androgen receptor	Homo sapiens	42-59
34445725-7	2021	In addition, UMB suppressed cell proliferation by reducing the expression of proliferating cell nuclear antigen (PCNA) and p-STAT3 (Tyr 705) in prostate tissue following TP injection.	7-hydroxycoumarin	13-16	proliferating cell nuclear antigen	Homo sapiens	77-111
34445725-7	2021	In addition, UMB suppressed cell proliferation by reducing the expression of proliferating cell nuclear antigen (PCNA) and p-STAT3 (Tyr 705) in prostate tissue following TP injection.	7-hydroxycoumarin	13-16	proliferating cell nuclear antigen	Homo sapiens	113-117
34445725-7	2021	In addition, UMB suppressed cell proliferation by reducing the expression of proliferating cell nuclear antigen (PCNA) and p-STAT3 (Tyr 705) in prostate tissue following TP injection.	7-hydroxycoumarin	13-16	signal transducer and activator of transcription 3	Rattus norvegicus	125-130
34156072-11	2022	UMB enhanced pituitary-gonadal axis and steroidogenesis and upregulated testicular PPARgamma in diabetic rats.	7-hydroxycoumarin	0-3	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	83-92
35378502-0	2022	Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell death in rats.	7-hydroxycoumarin	0-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
34169921-4	2021	The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-beta and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis.	7-hydroxycoumarin	35-37	fibronectin 1	Rattus norvegicus	171-182
34169921-4	2021	The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-beta and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis.	7-hydroxycoumarin	35-37	transforming growth factor alpha	Rattus norvegicus	238-246
34169921-4	2021	The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-beta and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis.	7-hydroxycoumarin	35-37	cellular communication network factor 2	Rattus norvegicus	251-255
35378502-0	2022	Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell death in rats.	7-hydroxycoumarin	0-13	heme oxygenase 1	Rattus norvegicus	84-88
35378502-5	2022	UMB effectively ameliorated myocardial injury, alleviated cardiac function markers, MDA, NO, NF-kappaB p65, and the inflammatory mediators, and enhanced cellular antioxidants.	7-hydroxycoumarin	0-3	synaptotagmin 1	Rattus norvegicus	103-106
35378502-6	2022	Bax, caspase-3, and 8-OHdG were decreased, and Bcl-2 was increased in ISO-administered rats treated with UMB.	7-hydroxycoumarin	105-108	BCL2 associated X, apoptosis regulator	Rattus norvegicus	0-3
35378502-6	2022	Bax, caspase-3, and 8-OHdG were decreased, and Bcl-2 was increased in ISO-administered rats treated with UMB.	7-hydroxycoumarin	105-108	caspase 3	Rattus norvegicus	5-14
35378502-6	2022	Bax, caspase-3, and 8-OHdG were decreased, and Bcl-2 was increased in ISO-administered rats treated with UMB.	7-hydroxycoumarin	105-108	BCL2, apoptosis regulator	Rattus norvegicus	47-52
35378502-8	2022	In conclusion, UMB can protect the myocardium from oxidative injury, inflammatory response, and cell death induced by ISO by upregulating Nrf2/HO-1 signaling and antioxidants.	7-hydroxycoumarin	15-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
35378502-8	2022	In conclusion, UMB can protect the myocardium from oxidative injury, inflammatory response, and cell death induced by ISO by upregulating Nrf2/HO-1 signaling and antioxidants.	7-hydroxycoumarin	15-18	heme oxygenase 1	Rattus norvegicus	143-147
35278496-0	2022	Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway.	7-hydroxycoumarin	0-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-118
35278496-0	2022	Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway.	7-hydroxycoumarin	0-13	heme oxygenase 1	Mus musculus	119-123
35278496-7	2022	RESULTS: We found that Umbelliferone can significantly improve the renal pathological damage and ROS accumulation of db/db mice, and inhibit ferroptosis, such as the down-regulation of ACSL4 and the up-regulation of GPX4.	7-hydroxycoumarin	23-36	acyl-CoA synthetase long-chain family member 4	Mus musculus	185-190
35278496-7	2022	RESULTS: We found that Umbelliferone can significantly improve the renal pathological damage and ROS accumulation of db/db mice, and inhibit ferroptosis, such as the down-regulation of ACSL4 and the up-regulation of GPX4.	7-hydroxycoumarin	23-36	glutathione peroxidase 4	Mus musculus	216-220
35278496-9	2022	We demonstrated that knockdown of Nrf2 blocked the inhibitory effect of Umbelliferone on ferroptosis in renal tubule cells induced by high glucose.	7-hydroxycoumarin	72-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
35278496-10	2022	CONCLUSION: These results suggest that Umbelliferone has a protective effect on DN, possibly by activating the Nrf2/HO-1 pathway, thus attenuating the level of high glucose-induced ferroptosis.	7-hydroxycoumarin	39-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
35278496-10	2022	CONCLUSION: These results suggest that Umbelliferone has a protective effect on DN, possibly by activating the Nrf2/HO-1 pathway, thus attenuating the level of high glucose-induced ferroptosis.	7-hydroxycoumarin	39-52	heme oxygenase 1	Mus musculus	116-120
3086205-2	1986	New methods are presented for the microdetermination of sulfotransferase and sulfatase activities in microdissected samples weighing 0.1 to 4 micrograms dry weight using umbelliferone and 4-methylumbelliferone sulfate as substrates.	7-hydroxycoumarin	170-183	arylsulfatase family member H	Homo sapiens	77-86
6182644-1	1982	Administration of the carcinogens, benzo[a]pyrene and 1,2-benzanthracene, increased UDP glucuronosyltransferase activities towards 4-nitrophenol, 3-hydroxybenzo[a]pyrene, 7-hydroxycoumarin and 1-naphthol to a greater extent than did pretreatment with the noncarcinogens, anthracene and phenanthrene.	7-hydroxycoumarin	171-188	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	84-111
6506757-0	1984	Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins.	7-hydroxycoumarin	68-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
6309775-4	1983	The Coh locus has previously been shown to code for a phenobarbital-inducible enzyme, believed to be a cytochrome P-450, which catalyzes the conversion of coumarin to 7-hydroxycoumarin (umbelliferone).	7-hydroxycoumarin	167-184	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	103-119
6309775-4	1983	The Coh locus has previously been shown to code for a phenobarbital-inducible enzyme, believed to be a cytochrome P-450, which catalyzes the conversion of coumarin to 7-hydroxycoumarin (umbelliferone).	7-hydroxycoumarin	186-199	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	103-119
13276338-2	1955	The biosynthesis of the glucuronides of umbelliferone and 4-methylumbelliferone and their use in fluorimetric determination of beta-glucuronidase.	7-hydroxycoumarin	40-53	glucuronidase beta	Homo sapiens	127-145
33502024-7	2021	However, umbelliferone pretreatment enhanced superoxide dismutase (SOD) and glutathione (GSH), levels, reduced MDA and MPO levels.	7-hydroxycoumarin	9-22	myeloperoxidase	Rattus norvegicus	119-122
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-114
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	cytoglobin	Rattus norvegicus	116-126
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	sirtuin 1	Rattus norvegicus	128-133
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	forkhead box O3	Rattus norvegicus	134-140
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-153
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	synaptotagmin 1	Rattus norvegicus	153-156
33522649-7	2021	On the contrary, the levels of renal function biomarkers, cytokines, NF-kB-p65, IkBalpha, IKKbeta, and oxidant/antioxidant status have been improved after UMB treatment.	7-hydroxycoumarin	155-158	NFKB inhibitor alpha	Rattus norvegicus	80-88
33522649-7	2021	On the contrary, the levels of renal function biomarkers, cytokines, NF-kB-p65, IkBalpha, IKKbeta, and oxidant/antioxidant status have been improved after UMB treatment.	7-hydroxycoumarin	155-158	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	90-97
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-49
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	cytoglobin	Rattus norvegicus	54-64
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	cAMP responsive element binding protein 1	Rattus norvegicus	126-130
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	sirtuin 1	Rattus norvegicus	132-137
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	forkhead box O3	Rattus norvegicus	139-145
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	147-157
33522649-9	2021	Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB, SIRT1, FOXO-3, PPAR-gamma, and NRF2 genes.	7-hydroxycoumarin	15-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	163-167
33128149-0	2021	Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-kappaB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.	7-hydroxycoumarin	0-13	toll-like receptor 4	Rattus norvegicus	77-82
33128149-0	2021	Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-kappaB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.	7-hydroxycoumarin	0-13	NLR family, pyrin domain containing 3	Rattus norvegicus	97-103
33128149-0	2021	Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-kappaB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.	7-hydroxycoumarin	0-13	Janus kinase 1	Rattus norvegicus	108-112
33128149-0	2021	Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-kappaB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.	7-hydroxycoumarin	0-13	signal transducer and activator of transcription 3	Rattus norvegicus	113-119
33128149-10	2021	In parallel, UMB induced IkBalpha upregulation.	7-hydroxycoumarin	13-16	NFKB inhibitor alpha	Rattus norvegicus	25-33
33502024-8	2021	Renal I/R increased in tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) levels, and histopathological changes but these effects were inhibited with umbelliferone pretreatment.	7-hydroxycoumarin	161-174	tumor necrosis factor	Rattus norvegicus	23-50
33502024-8	2021	Renal I/R increased in tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) levels, and histopathological changes but these effects were inhibited with umbelliferone pretreatment.	7-hydroxycoumarin	161-174	tumor necrosis factor	Rattus norvegicus	52-61
33502024-8	2021	Renal I/R increased in tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) levels, and histopathological changes but these effects were inhibited with umbelliferone pretreatment.	7-hydroxycoumarin	161-174	interleukin 6	Rattus norvegicus	64-77
33502024-8	2021	Renal I/R increased in tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) levels, and histopathological changes but these effects were inhibited with umbelliferone pretreatment.	7-hydroxycoumarin	161-174	interleukin 6	Rattus norvegicus	79-83
33502024-9	2021	Furthermore, umbelliferone increased in nitric oxide synthase (eNOS) level under ischemia conditions.	7-hydroxycoumarin	13-26	nitric oxide synthase 3	Rattus norvegicus	63-67
33502024-12	2021	The oral treatment of umbelliferone markedly reversed the oxidative stress, inflammation, and histopathological changes by increasing in the levels of SOD, GSH, and eNOS, decreasing in the levels of MDA, MPO, TNF-alpha, and IL-6 in distant organ injury induced by renal I/R.	7-hydroxycoumarin	22-35	nitric oxide synthase 3	Rattus norvegicus	165-169
33502024-12	2021	The oral treatment of umbelliferone markedly reversed the oxidative stress, inflammation, and histopathological changes by increasing in the levels of SOD, GSH, and eNOS, decreasing in the levels of MDA, MPO, TNF-alpha, and IL-6 in distant organ injury induced by renal I/R.	7-hydroxycoumarin	22-35	myeloperoxidase	Rattus norvegicus	204-207
33502024-12	2021	The oral treatment of umbelliferone markedly reversed the oxidative stress, inflammation, and histopathological changes by increasing in the levels of SOD, GSH, and eNOS, decreasing in the levels of MDA, MPO, TNF-alpha, and IL-6 in distant organ injury induced by renal I/R.	7-hydroxycoumarin	22-35	tumor necrosis factor	Rattus norvegicus	209-218
33502024-12	2021	The oral treatment of umbelliferone markedly reversed the oxidative stress, inflammation, and histopathological changes by increasing in the levels of SOD, GSH, and eNOS, decreasing in the levels of MDA, MPO, TNF-alpha, and IL-6 in distant organ injury induced by renal I/R.	7-hydroxycoumarin	22-35	interleukin 6	Rattus norvegicus	224-228
33484396-11	2021	Moreover, UF treatment significantly reduced the osteoclast number via modulating the RANKL/RANK/OPG ratio.	7-hydroxycoumarin	10-12	TNF superfamily member 11	Rattus norvegicus	86-91
33484396-11	2021	Moreover, UF treatment significantly reduced the osteoclast number via modulating the RANKL/RANK/OPG ratio.	7-hydroxycoumarin	10-12	TNF receptor superfamily member 11B	Rattus norvegicus	97-100
33484396-12	2021	Furthermore, administration of umbelliferone significantly (P < 0.001) suppressed the NF-kappaB and VEGF.	7-hydroxycoumarin	31-44	vascular endothelial growth factor A	Rattus norvegicus	100-104
32940040-5	2020	In this study, we identified a 7-hydroxycoumarin fluorophore with high affinity for the MIF tautomerase active site (Ki = 18+-1 nM) that binds with concomitant quenching of its fluorescence.	7-hydroxycoumarin	31-48	macrophage migration inhibitory factor	Homo sapiens	88-91
32889064-3	2020	Our results suggest that the vasorelaxant effect of 7-HC seems to rely on potassium channels, notably through large conductance Ca2+-activated K+ (BKCa) channels activation.	7-hydroxycoumarin	52-56	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	147-151
32940040-7	2020	We also demonstrated that the 7-hydroxycoumarin fluorophore interfered with the MIF-CD74 interaction and inhibited proliferation of A549 cells.	7-hydroxycoumarin	30-47	macrophage migration inhibitory factor	Homo sapiens	80-83
32940040-7	2020	We also demonstrated that the 7-hydroxycoumarin fluorophore interfered with the MIF-CD74 interaction and inhibited proliferation of A549 cells.	7-hydroxycoumarin	30-47	CD74 molecule	Homo sapiens	84-88
33061305-0	2020	Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling.	7-hydroxycoumarin	0-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	156-160
33061305-0	2020	Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling.	7-hydroxycoumarin	0-13	heme oxygenase 1	Rattus norvegicus	161-165
33061305-8	2020	In addition, UMB attenuated oxidative stress and oxidative DNA damage, downregulated the expression of pro-inflammatory mediators and Bax, boosted antioxidant defenses and Bcl-2, and upregulated Nrf2/HO-1 signaling in Pb-intoxicated rats.	7-hydroxycoumarin	13-16	BCL2 associated X, apoptosis regulator	Rattus norvegicus	134-137
33061305-8	2020	In addition, UMB attenuated oxidative stress and oxidative DNA damage, downregulated the expression of pro-inflammatory mediators and Bax, boosted antioxidant defenses and Bcl-2, and upregulated Nrf2/HO-1 signaling in Pb-intoxicated rats.	7-hydroxycoumarin	13-16	BCL2, apoptosis regulator	Rattus norvegicus	172-177
33061305-8	2020	In addition, UMB attenuated oxidative stress and oxidative DNA damage, downregulated the expression of pro-inflammatory mediators and Bax, boosted antioxidant defenses and Bcl-2, and upregulated Nrf2/HO-1 signaling in Pb-intoxicated rats.	7-hydroxycoumarin	13-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	195-199
33061305-8	2020	In addition, UMB attenuated oxidative stress and oxidative DNA damage, downregulated the expression of pro-inflammatory mediators and Bax, boosted antioxidant defenses and Bcl-2, and upregulated Nrf2/HO-1 signaling in Pb-intoxicated rats.	7-hydroxycoumarin	13-16	heme oxygenase 1	Rattus norvegicus	200-204
33061305-9	2020	Conclusion: UMB prevents Pb-induced testicular injury by suppressing oxidative damage, inflammation and cell death, and boosting antioxidant defenses, Nrf2/HO-1 signaling and pituitary-gonadal axis.	7-hydroxycoumarin	12-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	151-155
33061305-9	2020	Conclusion: UMB prevents Pb-induced testicular injury by suppressing oxidative damage, inflammation and cell death, and boosting antioxidant defenses, Nrf2/HO-1 signaling and pituitary-gonadal axis.	7-hydroxycoumarin	12-15	heme oxygenase 1	Rattus norvegicus	156-160
32651149-3	2020	In this study, UGT activities were analyzed in liver (five lobes) and small intestine (the duodenum and six sections from the proximal jejunum to the distal ileum) using typical probe substrates of human UGTs: 7-hydroxycoumarin, estradiol, serotonin, propofol, and zidovudine.	7-hydroxycoumarin	210-227	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	15-18
32250498-9	2020	Interestingly, xanthotoxin diminished phosphorylated JAK2 and phosphorylated STAT3 protein expression, while umbelliferone markedly replenished nuclear factor erythroid-derived 2-like 2 (Nrf2) and haem oxygenase-1 (HO-1) levels.	7-hydroxycoumarin	109-122	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-185
32250498-9	2020	Interestingly, xanthotoxin diminished phosphorylated JAK2 and phosphorylated STAT3 protein expression, while umbelliferone markedly replenished nuclear factor erythroid-derived 2-like 2 (Nrf2) and haem oxygenase-1 (HO-1) levels.	7-hydroxycoumarin	109-122	NFE2 like bZIP transcription factor 2	Rattus norvegicus	187-191
32552356-8	2021	Dose dependently treatment of umbelliferone down-regulated the neurological score, brain infarction, inflammatory mediator (TNF-alpha, IL-1beta, IL-6, COX-2, NF-kB and PGE2) in the serum and brain tissue as compared to I/R induced control group rats.	7-hydroxycoumarin	30-43	tumor necrosis factor	Rattus norvegicus	124-133
32848758-0	2020	7-Hydroxycoumarin Attenuates Colistin-Induced Kidney Injury in Mice Through the Decreased Level of Histone Deacetylase 1 and the Activation of Nrf2 Signaling Pathway.	7-hydroxycoumarin	0-17	histone deacetylase 1	Mus musculus	99-120
32848758-0	2020	7-Hydroxycoumarin Attenuates Colistin-Induced Kidney Injury in Mice Through the Decreased Level of Histone Deacetylase 1 and the Activation of Nrf2 Signaling Pathway.	7-hydroxycoumarin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	143-147
32848758-4	2020	In vivo experiments showed that 7-HC alleviated kidney injury induced by colistin, as indicated by lower levels of serum neutrophil gelatinase-associated lipocalin, blood urea nitrogen and creatinine levels.	7-hydroxycoumarin	32-36	lipocalin 2	Mus musculus	121-163
32848758-5	2020	Both in vivo and in vitro results demonstrated that 7-HC alleviated oxidative stress and apoptosis induced by colistin, as shown by decreased malondialdehyde levels, decreased caspase-3 and caspase-9 activities, and increased superoxide dismutase and catalase activities.	7-hydroxycoumarin	52-56	caspase 3	Mus musculus	176-185
32848758-5	2020	Both in vivo and in vitro results demonstrated that 7-HC alleviated oxidative stress and apoptosis induced by colistin, as shown by decreased malondialdehyde levels, decreased caspase-3 and caspase-9 activities, and increased superoxide dismutase and catalase activities.	7-hydroxycoumarin	52-56	caspase 9	Mus musculus	190-199
32848758-5	2020	Both in vivo and in vitro results demonstrated that 7-HC alleviated oxidative stress and apoptosis induced by colistin, as shown by decreased malondialdehyde levels, decreased caspase-3 and caspase-9 activities, and increased superoxide dismutase and catalase activities.	7-hydroxycoumarin	52-56	catalase	Mus musculus	251-259
32848758-7	2020	7-HC treatment restored histone acetylation at the Nrf2 promoter region and hence promoted Nrf2 expression.	7-hydroxycoumarin	0-4	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
32848758-7	2020	7-HC treatment restored histone acetylation at the Nrf2 promoter region and hence promoted Nrf2 expression.	7-hydroxycoumarin	0-4	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
32848758-8	2020	These results suggested that 7-HC alleviates colistin-induced renal injury and this effect was achieved by enhancement of renal antioxidant capacity with the decreased level of HDAC1 and the activation of Nrf2 signaling pathway.	7-hydroxycoumarin	29-33	histone deacetylase 1	Mus musculus	177-182
32848758-8	2020	These results suggested that 7-HC alleviates colistin-induced renal injury and this effect was achieved by enhancement of renal antioxidant capacity with the decreased level of HDAC1 and the activation of Nrf2 signaling pathway.	7-hydroxycoumarin	29-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	205-209
32552356-8	2021	Dose dependently treatment of umbelliferone down-regulated the neurological score, brain infarction, inflammatory mediator (TNF-alpha, IL-1beta, IL-6, COX-2, NF-kB and PGE2) in the serum and brain tissue as compared to I/R induced control group rats.	7-hydroxycoumarin	30-43	interleukin 1 alpha	Rattus norvegicus	135-143
32552356-8	2021	Dose dependently treatment of umbelliferone down-regulated the neurological score, brain infarction, inflammatory mediator (TNF-alpha, IL-1beta, IL-6, COX-2, NF-kB and PGE2) in the serum and brain tissue as compared to I/R induced control group rats.	7-hydroxycoumarin	30-43	interleukin 6	Rattus norvegicus	145-149
32552356-8	2021	Dose dependently treatment of umbelliferone down-regulated the neurological score, brain infarction, inflammatory mediator (TNF-alpha, IL-1beta, IL-6, COX-2, NF-kB and PGE2) in the serum and brain tissue as compared to I/R induced control group rats.	7-hydroxycoumarin	30-43	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	151-156
32552356-8	2021	Dose dependently treatment of umbelliferone down-regulated the neurological score, brain infarction, inflammatory mediator (TNF-alpha, IL-1beta, IL-6, COX-2, NF-kB and PGE2) in the serum and brain tissue as compared to I/R induced control group rats.	7-hydroxycoumarin	30-43	nuclear factor kappa B subunit 1	Rattus norvegicus	158-163
32017307-1	2020	The interaction of triazole substituted 4-methyl-7-hydroxycoumarin derivatives (CUM1-4) with serum albumin (bovine serum albumin [BSA] and human serum albumin [HSA]) have been studied employing ultraviolet-visible (UV-Vis), fluorescence, circular dichroism (CD) spectroscopy, and molecular docking methods at physiological pH 7.4.	7-hydroxycoumarin	40-66	albumin	Homo sapiens	93-106
32017307-1	2020	The interaction of triazole substituted 4-methyl-7-hydroxycoumarin derivatives (CUM1-4) with serum albumin (bovine serum albumin [BSA] and human serum albumin [HSA]) have been studied employing ultraviolet-visible (UV-Vis), fluorescence, circular dichroism (CD) spectroscopy, and molecular docking methods at physiological pH 7.4.	7-hydroxycoumarin	40-66	albumin	Homo sapiens	115-128
32017307-1	2020	The interaction of triazole substituted 4-methyl-7-hydroxycoumarin derivatives (CUM1-4) with serum albumin (bovine serum albumin [BSA] and human serum albumin [HSA]) have been studied employing ultraviolet-visible (UV-Vis), fluorescence, circular dichroism (CD) spectroscopy, and molecular docking methods at physiological pH 7.4.	7-hydroxycoumarin	40-66	albumin	Homo sapiens	115-128
32357811-3	2020	In thecase of MAO-B the rhamnetin, quercetin, piperine, eugenol,and umbelliferone exhibited highest dock score -10.57, -9.938, -9.445, - 8.757and 7.821respectively.	7-hydroxycoumarin	68-81	monoamine oxidase B	Homo sapiens	14-19
32357811-4	2020	In the case of MAO-A umbelliferone, curcumin, caffeic acid, quercetin possessed dock score -8.001, -7.941, -7.357, -6.658 respectively.	7-hydroxycoumarin	21-34	monoamine oxidase A	Homo sapiens	15-20
32357811-6	2020	Compound umbelliferone was observed as the most active hMAO-A inhibitor (IC50= 10.98+-0.006 microM) and selectivity index of 0.607.	7-hydroxycoumarin	9-22	monoamine oxidase A	Homo sapiens	55-61
32169782-0	2020	7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation.	7-hydroxycoumarin	0-17	SRY (sex determining region Y)-box 9	Mus musculus	113-117
32169782-12	2020	We found that 7-HC suppressed renal necroptosis via the RIPK1/RIPK3/MLKL pathway and accelerated renal repair as evidenced by the upregulation of cyclin D1 in cisplatin-induced nephropathy.	7-hydroxycoumarin	14-18	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	56-61
32169782-12	2020	We found that 7-HC suppressed renal necroptosis via the RIPK1/RIPK3/MLKL pathway and accelerated renal repair as evidenced by the upregulation of cyclin D1 in cisplatin-induced nephropathy.	7-hydroxycoumarin	14-18	receptor-interacting serine-threonine kinase 3	Mus musculus	62-67
32169782-12	2020	We found that 7-HC suppressed renal necroptosis via the RIPK1/RIPK3/MLKL pathway and accelerated renal repair as evidenced by the upregulation of cyclin D1 in cisplatin-induced nephropathy.	7-hydroxycoumarin	14-18	mixed lineage kinase domain-like	Mus musculus	68-72
32169782-12	2020	We found that 7-HC suppressed renal necroptosis via the RIPK1/RIPK3/MLKL pathway and accelerated renal repair as evidenced by the upregulation of cyclin D1 in cisplatin-induced nephropathy.	7-hydroxycoumarin	14-18	cyclin D1	Mus musculus	146-155
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	195-199
31557622-0	2019	Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidbeta aggregation, and lipid peroxidation.	7-hydroxycoumarin	0-13	monoamine oxidase A	Homo sapiens	70-89
31557622-9	2019	These represent the first experimental and modelling data for hMAO-A/B inhibition by umbelliferone derivatives.	7-hydroxycoumarin	85-98	monoamine oxidase A	Homo sapiens	62-70
31557622-10	2019	Together, the data suggest that introduction of a formyl moiety in the 7-hydroxycoumarin scaffold, especially at the 6 position, plays an important role in the inhibition of hMAOs, Abeta self-aggregation, and lipid peroxidation.	7-hydroxycoumarin	71-88	amyloid beta precursor protein	Rattus norvegicus	181-186
31557622-11	2019	Umbelliferone derivative 2 is a promising therapeutic lead scaffold for developing anti-neuropsychiatric disorder drugs that function via selective hMAO-A inhibition.	7-hydroxycoumarin	0-13	monoamine oxidase A	Homo sapiens	148-154
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	immunoglobulin heavy variable V1-9	Mus musculus	201-206
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	tumor necrosis factor	Mus musculus	208-217
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	interleukin 4	Mus musculus	223-236
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	interleukin 4	Mus musculus	238-242
31141780-3	2019	Here an umbelliferone derivative Umb-Pd2 was provided as a small, steady, safe and selective sensor for detecting Pd(II).	7-hydroxycoumarin	8-21	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	37-40
31163215-0	2019	Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity.	7-hydroxycoumarin	43-60	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	20-39
30272491-4	2019	Molecular modeling indicated that 3-phenylcoumarin offers an excellent scaffold for the development of selective substrate compounds for various human CYP forms, as they could be metabolized to fluorescent 7-hydroxycoumarin derivatives.	7-hydroxycoumarin	206-223	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	151-154
31163215-1	2019	Compared with coumarin, 7-hydroxycoumarin could serve as a better hit for developing CYP2A6 inhibitors.	7-hydroxycoumarin	24-41	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	85-91
31163215-2	2019	In this study, a series of 7-hydroxycoumarin and its structural analogues were collected to study their structure-activity relationship (SAR) and isoform selectivity for inhibiting CYP2A6.	7-hydroxycoumarin	27-44	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	181-187
30741365-0	2019	Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARgamma and Attenuating Oxidative Stress, Inflammation, and TGF-beta1/Smad3 Signaling.	7-hydroxycoumarin	0-13	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
30741365-0	2019	Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARgamma and Attenuating Oxidative Stress, Inflammation, and TGF-beta1/Smad3 Signaling.	7-hydroxycoumarin	0-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	78-87
30741365-0	2019	Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARgamma and Attenuating Oxidative Stress, Inflammation, and TGF-beta1/Smad3 Signaling.	7-hydroxycoumarin	0-13	transforming growth factor, beta 1	Rattus norvegicus	140-149
30741365-0	2019	Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARgamma and Attenuating Oxidative Stress, Inflammation, and TGF-beta1/Smad3 Signaling.	7-hydroxycoumarin	0-13	SMAD family member 3	Rattus norvegicus	150-155
30741365-3	2019	This study aimed to investigate the protective effect of UMB against carbon tetrachloride (CCl4)-induced liver fibrosis in rats.	7-hydroxycoumarin	57-60	C-C motif chemokine ligand 4	Rattus norvegicus	91-95
30741365-6	2019	Treatment with UMB significantly ameliorated liver function markers and pro-inflammatory cytokines and prevented CCl4-induced histological alterations.	7-hydroxycoumarin	15-18	C-C motif chemokine ligand 4	Rattus norvegicus	113-117
30741365-9	2019	Treatment with UMB suppressed TGF-beta1/Smad3 signaling and downregulated alpha-SMA, collagen I, collagen III, and NF-kappaB p65.	7-hydroxycoumarin	15-18	transforming growth factor, beta 1	Rattus norvegicus	30-39
30741365-9	2019	Treatment with UMB suppressed TGF-beta1/Smad3 signaling and downregulated alpha-SMA, collagen I, collagen III, and NF-kappaB p65.	7-hydroxycoumarin	15-18	SMAD family member 3	Rattus norvegicus	40-45
30741365-9	2019	Treatment with UMB suppressed TGF-beta1/Smad3 signaling and downregulated alpha-SMA, collagen I, collagen III, and NF-kappaB p65.	7-hydroxycoumarin	15-18	synaptotagmin 1	Rattus norvegicus	125-128
30741365-10	2019	In addition, UMB diminished malondialdehyde and nitric oxide levels, boosted reduced glutathione and antioxidant enzymes, and upregulated the expression of PPARgamma.	7-hydroxycoumarin	13-16	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	156-165
30741365-11	2019	In conclusion, our results demonstrated that UMB prevented CCl4-induced liver fibrosis by attenuating oxidative stress, inflammation, and TGF-beta1/Smad3 signaling, and upregulating PPARgamma.	7-hydroxycoumarin	45-48	C-C motif chemokine ligand 4	Rattus norvegicus	59-63
30741365-11	2019	In conclusion, our results demonstrated that UMB prevented CCl4-induced liver fibrosis by attenuating oxidative stress, inflammation, and TGF-beta1/Smad3 signaling, and upregulating PPARgamma.	7-hydroxycoumarin	45-48	transforming growth factor, beta 1	Rattus norvegicus	138-147
30741365-11	2019	In conclusion, our results demonstrated that UMB prevented CCl4-induced liver fibrosis by attenuating oxidative stress, inflammation, and TGF-beta1/Smad3 signaling, and upregulating PPARgamma.	7-hydroxycoumarin	45-48	SMAD family member 3	Rattus norvegicus	148-153
30741365-11	2019	In conclusion, our results demonstrated that UMB prevented CCl4-induced liver fibrosis by attenuating oxidative stress, inflammation, and TGF-beta1/Smad3 signaling, and upregulating PPARgamma.	7-hydroxycoumarin	45-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	182-191
31171269-0	2019	Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-kappaB pathway.	7-hydroxycoumarin	0-13	toll-like receptor 2	Rattus norvegicus	106-109
30645708-4	2019	Finally, the inhibitory effects of Umb on the expression of toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 (MyD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway proteins were also measured.	7-hydroxycoumarin	35-38	toll like receptor 4	Homo sapiens	60-80
30645708-4	2019	Finally, the inhibitory effects of Umb on the expression of toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 (MyD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway proteins were also measured.	7-hydroxycoumarin	35-38	toll like receptor 4	Homo sapiens	82-86
30645708-4	2019	Finally, the inhibitory effects of Umb on the expression of toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 (MyD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway proteins were also measured.	7-hydroxycoumarin	35-38	MYD88 innate immune signal transduction adaptor	Homo sapiens	124-129
30645708-4	2019	Finally, the inhibitory effects of Umb on the expression of toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 (MyD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway proteins were also measured.	7-hydroxycoumarin	35-38	nuclear factor kappa B subunit 1	Homo sapiens	154-163
31259714-0	2019	The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110gamma catalytic subunit of PI3Kgamma.	7-hydroxycoumarin	26-39	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	92-101
30645708-0	2019	Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-kappaB Signaling.	7-hydroxycoumarin	0-13	toll like receptor 4	Homo sapiens	115-119
30645708-0	2019	Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-kappaB Signaling.	7-hydroxycoumarin	0-13	MYD88 innate immune signal transduction adaptor	Homo sapiens	120-125
30645708-0	2019	Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-kappaB Signaling.	7-hydroxycoumarin	0-13	nuclear factor kappa B subunit 1	Homo sapiens	126-135
30645708-3	2019	In addition, Umb resulted in significant anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity compared with the LPS group.	7-hydroxycoumarin	13-16	myeloperoxidase	Homo sapiens	86-101
30645708-3	2019	In addition, Umb resulted in significant anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity compared with the LPS group.	7-hydroxycoumarin	13-16	myeloperoxidase	Homo sapiens	103-106
30645708-3	2019	In addition, Umb resulted in significant anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity compared with the LPS group.	7-hydroxycoumarin	13-16	superoxide dismutase 1	Homo sapiens	157-177
30645708-3	2019	In addition, Umb resulted in significant anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity compared with the LPS group.	7-hydroxycoumarin	13-16	superoxide dismutase 1	Homo sapiens	179-182
31259714-3	2019	Our results have revealed that treatment of human RCC cells (786-O, OS-RC-2, and ACHN) with umbelliferone reduced cell proliferation in a concentration-dependent manner and induced dose-dependent apoptotic events.	7-hydroxycoumarin	92-105	La ribonucleoprotein 6, translational regulator	Homo sapiens	81-85
31259714-5	2019	Furthermore, western blotting analysis showed a dose-dependent decrease in Ki67, MCM2, Bcl-2, CDK2, CyclinE1, CDK4, and CyclinD1 and a dose-dependent increase in Bax in RCC cells cultured with umbelliferone.	7-hydroxycoumarin	193-206	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
31259714-6	2019	Similarly, umbelliferone exhibited a dose-dependent reduction of p110gamma when using western blotting analyses.	7-hydroxycoumarin	11-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	65-74
31259714-7	2019	Taken together, these results provide an insight into the pharmacology regarding the potential application of umbelliferone, which contributes to cell death by decreasing p110gamma protein expression.	7-hydroxycoumarin	110-123	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	171-180
30584780-7	2019	The mechanisms and kinetics of enzyme inhibition of coumarin, aesculetin, umbelliferone, and scopoletin using the cell lysates as a source of NQO1 enzyme best fit with an uncompetitive inhibition model.	7-hydroxycoumarin	74-87	NAD(P)H quinone dehydrogenase 1	Homo sapiens	142-146
29967293-0	2018	Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant.	7-hydroxycoumarin	0-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
29807243-1	2018	A novel compound, Cou-platin, composed of 7-hydroxycoumarin and a platinum(IV) moiety derived from cisplatin was designed and synthesized.	7-hydroxycoumarin	42-59	brachyury, T-box transcription factor T	Mus musculus	18-21
29807243-2	2018	Significantly, Cou-platin exhibited more potent in vitro antitumor activity against all tested cancer cell lines than that of cisplatin, which was mainly attributed to the liberation of cisplatin and 7-hydroxycoumarin upon reduction with a biomolecular agent.	7-hydroxycoumarin	200-217	brachyury, T-box transcription factor T	Mus musculus	15-18
29197732-3	2018	By decorating the natural compound umbelliferone (1) we have identified a new series of coumarin-based compounds demonstrating high CA inhibitory effects with nanomolar affinity for hCA IX and hCA XII isoforms that were considered a target amenable to develop antitumor agents.	7-hydroxycoumarin	35-48	carbonic anhydrase 9	Homo sapiens	182-188
29709425-5	2018	Using this standardised assay, the rates of sulphation (SULT) and glucuronidation (UGT) of 7-hydroxycoumarin, methylation (COMT) of dopamine and N-acetylation (NAT) of procainamide were measured in the ng/mg protein/h (converted to ng/cm2/h) range in eighty-seven individuals.	7-hydroxycoumarin	91-108	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	83-86
29573618-10	2018	Hyperammonemic rats showed elevated levels of cerebral TNF-alpha, IL-1beta and glutamine as well as increased activity and expression of Na+/K+-ATPase, effects that were significantly reversed by UMB.	7-hydroxycoumarin	196-199	tumor necrosis factor	Rattus norvegicus	55-64
29573618-10	2018	Hyperammonemic rats showed elevated levels of cerebral TNF-alpha, IL-1beta and glutamine as well as increased activity and expression of Na+/K+-ATPase, effects that were significantly reversed by UMB.	7-hydroxycoumarin	196-199	interleukin 1 beta	Rattus norvegicus	66-74
29608980-0	2018	Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-kappaB, and apoptosis signaling pathways.	7-hydroxycoumarin	26-39	NFE2 like bZIP transcription factor 2	Homo sapiens	99-104
29608980-0	2018	Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-kappaB, and apoptosis signaling pathways.	7-hydroxycoumarin	26-39	kelch like ECH associated protein 1	Homo sapiens	105-111
29608980-0	2018	Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-kappaB, and apoptosis signaling pathways.	7-hydroxycoumarin	26-39	nuclear factor kappa B subunit 1	Homo sapiens	121-130
29188498-6	2018	The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration.	7-hydroxycoumarin	185-188	tumor necrosis factor	Rattus norvegicus	61-88
29188498-6	2018	The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration.	7-hydroxycoumarin	185-188	tumor necrosis factor	Rattus norvegicus	90-99
29188498-6	2018	The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration.	7-hydroxycoumarin	185-188	interleukin 1 beta	Rattus norvegicus	102-120
29188498-6	2018	The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration.	7-hydroxycoumarin	185-188	interleukin 1 beta	Rattus norvegicus	122-130
29188498-6	2018	The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration.	7-hydroxycoumarin	185-188	interleukin 6	Rattus norvegicus	137-141
29257247-4	2018	Compared with the myocardial injury following ischemia-reperfusion group, umbelliferone significantly prevented myocardial injury, inhibited oxidative stress markers (superoxide dismutase and malondialdehyde), reduced inflammation (tumor necrosis factor-alpha and interleukin-6) and myocardial apoptosis levels (caspase-3/9 and apoptosis regular B-cell lymphoma-2-associated X protein) in the myocardial injury following ischemia-reperfusion group of rats.	7-hydroxycoumarin	74-87	tumor necrosis factor	Rattus norvegicus	232-259
29257247-4	2018	Compared with the myocardial injury following ischemia-reperfusion group, umbelliferone significantly prevented myocardial injury, inhibited oxidative stress markers (superoxide dismutase and malondialdehyde), reduced inflammation (tumor necrosis factor-alpha and interleukin-6) and myocardial apoptosis levels (caspase-3/9 and apoptosis regular B-cell lymphoma-2-associated X protein) in the myocardial injury following ischemia-reperfusion group of rats.	7-hydroxycoumarin	74-87	interleukin 6	Rattus norvegicus	264-277
29257247-4	2018	Compared with the myocardial injury following ischemia-reperfusion group, umbelliferone significantly prevented myocardial injury, inhibited oxidative stress markers (superoxide dismutase and malondialdehyde), reduced inflammation (tumor necrosis factor-alpha and interleukin-6) and myocardial apoptosis levels (caspase-3/9 and apoptosis regular B-cell lymphoma-2-associated X protein) in the myocardial injury following ischemia-reperfusion group of rats.	7-hydroxycoumarin	74-87	caspase 3	Rattus norvegicus	312-323
29257247-5	2018	Umbelliferone treatment also suppressed NACHT, LRR and NLRP3 inflammasome activation and induced PPAR-gamma expression.	7-hydroxycoumarin	0-13	NLR family, pyrin domain containing 3	Rattus norvegicus	55-60
29257247-5	2018	Umbelliferone treatment also suppressed NACHT, LRR and NLRP3 inflammasome activation and induced PPAR-gamma expression.	7-hydroxycoumarin	0-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	97-107
29257247-6	2018	The results of the present study suggested that the protective effect of umbelliferone may ameliorate myocardial injury following ischemia-reperfusion in the rat through the suppression of the NLRP3 inflammasome and upregulating PPAR-gamma expression.	7-hydroxycoumarin	73-86	NLR family, pyrin domain containing 3	Rattus norvegicus	193-198
29257247-6	2018	The results of the present study suggested that the protective effect of umbelliferone may ameliorate myocardial injury following ischemia-reperfusion in the rat through the suppression of the NLRP3 inflammasome and upregulating PPAR-gamma expression.	7-hydroxycoumarin	73-86	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	229-239
29298653-6	2018	RESULTS: Among all tested analogs, compound 5, displayed better cytotoxic activity as compared to the parent 7- hydroxycoumarin (1) with IC50 of 5.1, 22.7, 14.3 and 10.2 microM against breast (MCF-7), lung (NCI- H322), prostate (PC-3) and skin (A-431) cancer cell lines, respectively; the compound 5 was 8-fold more sensitive against MCF-7 than the parent 7-hydroxycoumarin.	7-hydroxycoumarin	109-127	chromobox 8	Homo sapiens	229-233
27894244-7	2018	METHODS: In this work we have evaluated effects of umbelliferone and acetazolamide in a high resistant melanoma cell line (A375) over expressing CA IX.	7-hydroxycoumarin	51-64	carbonic anhydrase 9	Homo sapiens	145-150
27894244-13	2018	Umbelliferone induced a more important pHi decrease than Acetalozamide from 7.3 to 7.08 and to 7.12 respectively, and a more important decrease in s-CA IX fraction showing a decrease in CA IX function.	7-hydroxycoumarin	0-13	carbonic anhydrase 9	Homo sapiens	149-154
27894244-13	2018	Umbelliferone induced a more important pHi decrease than Acetalozamide from 7.3 to 7.08 and to 7.12 respectively, and a more important decrease in s-CA IX fraction showing a decrease in CA IX function.	7-hydroxycoumarin	0-13	carbonic anhydrase 9	Homo sapiens	186-191
29197732-3	2018	By decorating the natural compound umbelliferone (1) we have identified a new series of coumarin-based compounds demonstrating high CA inhibitory effects with nanomolar affinity for hCA IX and hCA XII isoforms that were considered a target amenable to develop antitumor agents.	7-hydroxycoumarin	35-48	carbonic anhydrase 12	Homo sapiens	193-200
29128808-12	2017	CONCLUSION: Umbelliferone treatment can significantly reduce the diabetes induced renal damage and can improve the pathological conditions related to the diabetic nephropathy by down regulation of TGF-beta.	7-hydroxycoumarin	12-25	transforming growth factor, beta 1	Rattus norvegicus	197-205
30430943-5	2018	METHOD: A series of different umbelliferone derivatives was designed and synthesized, and the derivatives were screened for hMAO-A and hMAO-B inhibition.	7-hydroxycoumarin	30-43	monoamine oxidase A	Homo sapiens	124-141
29144746-3	2017	All the compounds except for ferulic acid, boropinic acid, and umbelliferone had binding affinities to melatonin receptors in the nM to muM range, and both auraptene and umbellinprenin reduced BC cell proliferation and migration in phenotypically diverse BC including triple negative.	7-hydroxycoumarin	63-76	latexin	Homo sapiens	136-139
28263721-0	2017	Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2.	7-hydroxycoumarin	27-44	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
28263721-6	2017	In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC.	7-hydroxycoumarin	87-91	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
28263721-6	2017	In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC.	7-hydroxycoumarin	87-91	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
28263721-6	2017	In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC.	7-hydroxycoumarin	179-183	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
28263721-6	2017	In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC.	7-hydroxycoumarin	179-183	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
28263721-7	2017	These findings highlight the potential for the interventional activation of the NRF2 induction via the non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the detoxification of MG, with the aim of halting the progression of diseases in which MG has been implicated.	7-hydroxycoumarin	135-139	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84