PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9068945-9	1997	As measured by rhodopsin levels 2 weeks after light exposure, DMTU-treated rats exhibited no loss of photoreceptor cells, whereas those not given the antioxidant lost over 50% of their photoreceptors.	1,3-dimethylthiourea	62-66	rhodopsin	Rattus norvegicus	15-24
9003470-0	1996	Increased microvascular permeability induced by prolonged interleukin-2 administration is attenuated by the oxygen-free-radical scavenger dimethylthiourea.	1,3-dimethylthiourea	138-154	interleukin 2	Mus musculus	58-71
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	1,3-dimethylthiourea	34-50	interleukin-2	Ovis aries	81-85
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	1,3-dimethylthiourea	34-50	interleukin-2	Ovis aries	145-149
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	1,3-dimethylthiourea	52-56	interleukin-2	Ovis aries	81-85
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	1,3-dimethylthiourea	52-56	interleukin-2	Ovis aries	145-149
9003470-4	1996	The present study tests whether DMTU attenuates IL-2-induced vascular leak syndrome following multiple IL-2 injections without affecting IL-2-induced cytotoxicity in peritoneal mononuclear cells.	1,3-dimethylthiourea	32-36	interleukin 2	Mus musculus	48-52
9003470-11	1996	In conclusion, we have shown that DMTU ameliorates pulmonary permeability and vascular leak syndrome associated with multiple-dose IL-2 therapy, without eliciting an inhibitory effect on IL-2 induced-cytotoxicity.	1,3-dimethylthiourea	34-38	interleukin 2	Mus musculus	131-135
8777211-11	1996	Compared with the control survivors (n = 4) at 8 hours after the operation, the dimethylthiourea survivors (n = 7) had a higher mean arterial oxygen pressure (144 +/- 21 versus 98+/- 12 mm Hg) and cardiac output (2.2 +/- 0.2 versus 1.6 +/- 0.2 L/min) and a lower mean pulmonary vascular resistance (946 +/- 96 versus 1414 +/- 128 dynes.sec-1.cm5, p < 0.05) and extravascular lung water (10.6 +/- 1.2 versus 12.3 +/- 3.2 ml/kg).	1,3-dimethylthiourea	80-96	secretory blood group 1, pseudogene	Homo sapiens	336-341
8906209-7	1996	The ROI scavengers, dimethylthiourea (4 mM), and dimethyl sulfoxide (0.001%), enhanced TNF alpha-induced ICAM-1 expression.	1,3-dimethylthiourea	20-36	tumor necrosis factor	Homo sapiens	87-96
8906209-7	1996	The ROI scavengers, dimethylthiourea (4 mM), and dimethyl sulfoxide (0.001%), enhanced TNF alpha-induced ICAM-1 expression.	1,3-dimethylthiourea	20-36	intercellular adhesion molecule 1	Homo sapiens	105-111
8770966-6	1996	In contrast, the ROS scavengers dimethylthiourea (DMTU), dimethylpyrroline N-oxide, or pyrrolidine dithiocarbamate reduced basal ET-1 release, while DMTU lowered ET-1 mRNA levels.	1,3-dimethylthiourea	32-48	endothelin 1	Homo sapiens	129-133
8631141-5	1996	The expression of Cx26 and Cx32 in the cultured hepatocytes was markedly induced by DMSO and DMTU.	1,3-dimethylthiourea	93-97	gap junction protein, beta 2	Rattus norvegicus	18-22
8631141-5	1996	The expression of Cx26 and Cx32 in the cultured hepatocytes was markedly induced by DMSO and DMTU.	1,3-dimethylthiourea	93-97	gap junction protein, beta 1	Rattus norvegicus	27-31
8856246-10	1996	Since morphine activates MC to produce superoxide and DMTU attenuated the effect of superoxide on MC, the effect of morphine on the migration of macrophages may be mediated through superoxide-induced generation of MCP-1.	1,3-dimethylthiourea	54-58	C-C motif chemokine ligand 2	Homo sapiens	214-219
8770966-6	1996	In contrast, the ROS scavengers dimethylthiourea (DMTU), dimethylpyrroline N-oxide, or pyrrolidine dithiocarbamate reduced basal ET-1 release, while DMTU lowered ET-1 mRNA levels.	1,3-dimethylthiourea	32-48	endothelin 1	Homo sapiens	162-166
8770966-6	1996	In contrast, the ROS scavengers dimethylthiourea (DMTU), dimethylpyrroline N-oxide, or pyrrolidine dithiocarbamate reduced basal ET-1 release, while DMTU lowered ET-1 mRNA levels.	1,3-dimethylthiourea	50-54	endothelin 1	Homo sapiens	129-133
8770966-6	1996	In contrast, the ROS scavengers dimethylthiourea (DMTU), dimethylpyrroline N-oxide, or pyrrolidine dithiocarbamate reduced basal ET-1 release, while DMTU lowered ET-1 mRNA levels.	1,3-dimethylthiourea	149-153	endothelin 1	Homo sapiens	162-166
7554117-6	1995	This enhancement was attenuated by iron chelation with deferoxamine and by the intracellular hydroxyl scavenger dimethylthiourea and mimicked by preincubation with purine/xanthine oxidase either alone or in the presence of superoxide dismutase.	1,3-dimethylthiourea	112-128	xanthine dehydrogenase	Mus musculus	171-187
8587253-5	1995	The 3CH134/CL100 mRNA expression was modulated by the ROI scavenger dimethylthiourea (DMTU), indicating that its induction was ROI related.	1,3-dimethylthiourea	68-84	dual specificity phosphatase 1	Rattus norvegicus	11-16
8587253-5	1995	The 3CH134/CL100 mRNA expression was modulated by the ROI scavenger dimethylthiourea (DMTU), indicating that its induction was ROI related.	1,3-dimethylthiourea	86-90	dual specificity phosphatase 1	Rattus norvegicus	11-16
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P < 0.05).	1,3-dimethylthiourea	59-75	interleukin 1 beta	Mus musculus	116-125
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P < 0.05).	1,3-dimethylthiourea	77-81	interleukin 1 beta	Mus musculus	116-125
7996046-6	1994	Dimethylthiourea and thiourea, but not urea and superoxide dismutase, dose-dependently inhibited NAC-mediated enhancement of HIV-1 replication.	1,3-dimethylthiourea	0-16	X-linked Kx blood group	Homo sapiens	97-100
7654323-6	1994	Animals pretreated with DMTU showed a delay in the initial increase in clusterin mRNA levels, suggesting that oxidative damage is involved in the damage mechanism.	1,3-dimethylthiourea	24-28	clusterin	Rattus norvegicus	71-80
7862656-0	1995	Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea.	1,3-dimethylthiourea	101-117	heme oxygenase 1	Rattus norvegicus	13-29
7862656-9	1995	Most important, treatment of animals with 1,3-dimethylthiourea, a synthetic antioxidant, prior to light exposure effectively blocked the increase in HO-1 mRNA.	1,3-dimethylthiourea	42-62	heme oxygenase 1	Rattus norvegicus	149-153
7532433-6	1994	beta 1 integrin expression on mesangial cells was higher by the addition of CM of MNC in MsPGN than in Control, which was prevented by anti-TGF beta antibody or dimethylthiourea.	1,3-dimethylthiourea	161-177	integrin subunit beta 1	Homo sapiens	0-15
8284091-5	1993	Glutathione and 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, partly prevented the nucleotide depletion (adenine nucleotide radioactivity 15 +/- 6% to 33 +/- 13% of total), but scavengers of the hydroxyl radical, dimethylthiourea and DMSO, as well as vitamins E and C, were without effect.	1,3-dimethylthiourea	229-245	poly(ADP-ribose) polymerase 1	Homo sapiens	50-76
7524120-3	1994	This bradykinin-induced oxidation of DCFH was inhibited by pretreatment with N-(2-mercaptopropionyl)-glycine (MPG) and 1,3-dimethyl-thiourea (DMTU), scavengers of hydroxyl radical, and the removal of extracellular Ca2+ but was unaffected by NG-nitro-L-arginine or NG-monomethyl-L-arginine, both inhibitors of nitric oxide (NO) synthase.	1,3-dimethylthiourea	119-140	kininogen 1	Bos taurus	5-15
7524120-3	1994	This bradykinin-induced oxidation of DCFH was inhibited by pretreatment with N-(2-mercaptopropionyl)-glycine (MPG) and 1,3-dimethyl-thiourea (DMTU), scavengers of hydroxyl radical, and the removal of extracellular Ca2+ but was unaffected by NG-nitro-L-arginine or NG-monomethyl-L-arginine, both inhibitors of nitric oxide (NO) synthase.	1,3-dimethylthiourea	142-146	kininogen 1	Bos taurus	5-15
7524120-5	1994	These findings suggest that bradykinin increases intracellular Ca2+ and stimulates the generation of hydroxyl radical-like reactive oxygen species (scavenged by MPG or DMTU) via the cyclooxygenase pathway but not via the reaction of NO and superoxide anion.	1,3-dimethylthiourea	168-172	kininogen 1	Bos taurus	28-38
8166243-2	1994	The ANG II-induced peak [Ca2+]i increase was significantly enhanced after inhibition of Na(+)-Ca2+ exchange by NiCl2 or 1,3-dimethyl-2-thiourea (DMTU): control, 99 +/- 9 (SE) nM (n = 64); NiCl2, 181 +/- 23 nM (n = 23; P < 0.01); DMTU, 182 +/- 35 nM (n = 10; P < 0.05).	1,3-dimethylthiourea	120-143	angiotensinogen	Rattus norvegicus	4-10
8166243-2	1994	The ANG II-induced peak [Ca2+]i increase was significantly enhanced after inhibition of Na(+)-Ca2+ exchange by NiCl2 or 1,3-dimethyl-2-thiourea (DMTU): control, 99 +/- 9 (SE) nM (n = 64); NiCl2, 181 +/- 23 nM (n = 23; P < 0.01); DMTU, 182 +/- 35 nM (n = 10; P < 0.05).	1,3-dimethylthiourea	145-149	angiotensinogen	Rattus norvegicus	4-10
8166243-2	1994	The ANG II-induced peak [Ca2+]i increase was significantly enhanced after inhibition of Na(+)-Ca2+ exchange by NiCl2 or 1,3-dimethyl-2-thiourea (DMTU): control, 99 +/- 9 (SE) nM (n = 64); NiCl2, 181 +/- 23 nM (n = 23; P < 0.01); DMTU, 182 +/- 35 nM (n = 10; P < 0.05).	1,3-dimethylthiourea	232-236	angiotensinogen	Rattus norvegicus	4-10
1363120-4	1992	N,N"-Dimethylthiourea (DMTU), a scavenger of oxygen free radicals, inhibited this increase in the urinary excretion of gamma-GTP.	1,3-dimethylthiourea	0-21	gamma-glutamyltransferase 1	Rattus norvegicus	119-128
8214084-6	1993	The decrease in ACE activity was also inhibited by the hydroxyl radical scavenger dimethylthiourea (5 mM) but not mannitol (5 mM), which does not cross cell membranes.	1,3-dimethylthiourea	82-98	angiotensin I converting enzyme	Bos taurus	16-19
8430431-4	1993	Seven days of daily DMTU therapy significantly (P < 0.001) increased renal and hepatic GSH content by 36 and 54%, respectively, which was associated with a significant (P < 0.001) increase in the renal activities of glutathione peroxidase (GP) by 38%, glutathione transferase (GT) by 92%, and glutathione reductase (GR) by 19% (P < 0.05).	1,3-dimethylthiourea	20-24	glutathione S-transferase alpha 4	Rattus norvegicus	258-281
8430431-4	1993	Seven days of daily DMTU therapy significantly (P < 0.001) increased renal and hepatic GSH content by 36 and 54%, respectively, which was associated with a significant (P < 0.001) increase in the renal activities of glutathione peroxidase (GP) by 38%, glutathione transferase (GT) by 92%, and glutathione reductase (GR) by 19% (P < 0.05).	1,3-dimethylthiourea	20-24	glutathione-disulfide reductase	Rattus norvegicus	299-320
8430431-4	1993	Seven days of daily DMTU therapy significantly (P < 0.001) increased renal and hepatic GSH content by 36 and 54%, respectively, which was associated with a significant (P < 0.001) increase in the renal activities of glutathione peroxidase (GP) by 38%, glutathione transferase (GT) by 92%, and glutathione reductase (GR) by 19% (P < 0.05).	1,3-dimethylthiourea	20-24	glutathione-disulfide reductase	Rattus norvegicus	322-324
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	1,3-dimethylthiourea	89-106	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1363120-4	1992	N,N"-Dimethylthiourea (DMTU), a scavenger of oxygen free radicals, inhibited this increase in the urinary excretion of gamma-GTP.	1,3-dimethylthiourea	23-27	gamma-glutamyltransferase 1	Rattus norvegicus	119-128
1363120-5	1992	DMTU also inhibited the increase in cisplatin-induced NAG excretion caused by the GSH depletors.	1,3-dimethylthiourea	0-4	O-GlcNAcase	Rattus norvegicus	54-57
1682068-11	1991	H2O2-induced PMN retention was completely inhibited by addition of catalase or the hydroxyl radical scavenger dimethylthiourea to the perfusate by incubation of the PMN with a monoclonal antibody (Mab) against CD18 (R15.7) or by perfusion of the H2O2-treated vessel with CL18/6, a Mab against canine ICAM-1 (intercellular adhesion molecule-1).	1,3-dimethylthiourea	110-126	intercellular adhesion molecule 1	Canis lupus familiaris	300-306
1559759-9	1992	For rats reared in the weak cyclic light environment, DMTU (two injections) provided complete protection against rhodopsin loss after intense light exposures of up to 16 hr.	1,3-dimethylthiourea	54-58	rhodopsin	Rattus norvegicus	113-122
1559759-10	1992	Only 15% rhodopsin loss was found in cyclic-light DMTU-treated rats after 24 hr of intermittent or continuous light.	1,3-dimethylthiourea	50-54	rhodopsin	Rattus norvegicus	9-18
1559759-11	1992	For rats reared in darkness, DMTU treatment resulted in a rhodopsin loss of less than 20% after 8-16 hr of continuous light and approximately 40% after similar exposure to intermittent light.	1,3-dimethylthiourea	29-33	rhodopsin	Rattus norvegicus	58-67
1559759-12	1992	Irrespective of the type of light exposure, rhodopsin loss in the dark-reared DMTU-treated rats was nearly identical to that found in uninjected cyclic light-reared animals.	1,3-dimethylthiourea	78-82	rhodopsin	Rattus norvegicus	44-53
1559759-14	1992	As measured by rhodopsin levels 2 weeks later, DMTU was most effective when given as two doses administered 24 hr before and just before intense light exposure.	1,3-dimethylthiourea	47-51	rhodopsin	Rattus norvegicus	15-24
1682068-11	1991	H2O2-induced PMN retention was completely inhibited by addition of catalase or the hydroxyl radical scavenger dimethylthiourea to the perfusate by incubation of the PMN with a monoclonal antibody (Mab) against CD18 (R15.7) or by perfusion of the H2O2-treated vessel with CL18/6, a Mab against canine ICAM-1 (intercellular adhesion molecule-1).	1,3-dimethylthiourea	110-126	intercellular adhesion molecule 1	Canis lupus familiaris	308-341
2109751-10	1990	Treatment with DMTU significantly reduced brain edema in the central and intermediate zones at both 4 and 24 h. However, CBF in the DMTU-treated animals was identical to that of the vehicle-treated animals.	1,3-dimethylthiourea	132-136	CCAAT/enhancer binding protein zeta	Rattus norvegicus	121-124
1960147-5	1991	Specific scavenging of free radical activity by the enzymes catalase and superoxide dismutase, the hydroxyl radical inhibitors dimethyl sulfoxide and dimethylthiourea (DMTU) and by chelation of intracellular free iron with deferoxamine produced only a partial restoration of [3H]thymidine incorporation into DNA, which was maximal for DMTU (30% of normal incorporation).	1,3-dimethylthiourea	150-166	catalase	Rattus norvegicus	60-68
1960147-5	1991	Specific scavenging of free radical activity by the enzymes catalase and superoxide dismutase, the hydroxyl radical inhibitors dimethyl sulfoxide and dimethylthiourea (DMTU) and by chelation of intracellular free iron with deferoxamine produced only a partial restoration of [3H]thymidine incorporation into DNA, which was maximal for DMTU (30% of normal incorporation).	1,3-dimethylthiourea	335-339	catalase	Rattus norvegicus	60-68
2124103-7	1990	Rhodopsin levels were significantly higher in the dimethylthiourea-treated rats 6 hours and 14 days after light exposure, while rhodopsin levels were comparable in the control and dimethylthiourea-treated rats 6 days after exposure.	1,3-dimethylthiourea	50-66	rhodopsin	Rattus norvegicus	0-9
2124103-8	1990	The differences in morphometry and rhodopsin levels between the control and dimethylthiourea-treated rats were statistically significant in relationship to dimethylthiourea treatment.	1,3-dimethylthiourea	76-92	rhodopsin	Rattus norvegicus	35-44
2124103-8	1990	The differences in morphometry and rhodopsin levels between the control and dimethylthiourea-treated rats were statistically significant in relationship to dimethylthiourea treatment.	1,3-dimethylthiourea	156-172	rhodopsin	Rattus norvegicus	35-44
1899491-11	1991	Pretreatment with the hydroxyl radical scavenger dimethylthiourea, 1 gm/kg, intravenously, (n = 6) prevented the interleukin-2-induced increase in mean pulmonary artery pressure, lung lymph flow, lymph/plasma protein ration, lymph protein clearance, and thromboxane B2 levels in plasma and lung lymph.	1,3-dimethylthiourea	49-65	interleukin-2	Ovis aries	113-126
2107864-0	1990	Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice.	1,3-dimethylthiourea	0-16	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	76-95
2107864-4	1990	These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide.	1,3-dimethylthiourea	51-55	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	13-32
2107864-1	1990	Dimethylthiourea (DMTU), a potent scavenger of hydroxyl radicals, was studied to see if it attenuated the inactivation of methionine synthase produced by nitrous oxide in mice.	1,3-dimethylthiourea	0-16	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	122-141
2107864-4	1990	These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide.	1,3-dimethylthiourea	190-194	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	13-32
2107864-5	1990	Greater differences in methionine synthase activities between the DMTU- and saline-injected animals were observed with increasing doses of DMTU.	1,3-dimethylthiourea	66-70	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	23-42
2551876-0	1989	Effect of dimethylthiourea on the neutrophil myeloperoxidase pathway.	1,3-dimethylthiourea	10-26	myeloperoxidase	Homo sapiens	45-60
2107864-5	1990	Greater differences in methionine synthase activities between the DMTU- and saline-injected animals were observed with increasing doses of DMTU.	1,3-dimethylthiourea	139-143	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	23-42
2107864-7	1990	DMTU exhibited its greatest effect in the kidney, where methionine synthase activities were nearly doubled in the DMTU 2.0 mg g-1-injected compared with the saline-injected mice after 1-h exposure to 66% nitrous oxide.	1,3-dimethylthiourea	0-4	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	56-75
2107864-7	1990	DMTU exhibited its greatest effect in the kidney, where methionine synthase activities were nearly doubled in the DMTU 2.0 mg g-1-injected compared with the saline-injected mice after 1-h exposure to 66% nitrous oxide.	1,3-dimethylthiourea	114-118	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	56-75
2107864-8	1990	Following a marked inactivation of methionine synthase by exposing mice to 66% nitrous oxide for 4 h, injection of DMTU 2.0 mg g-1 at the end of exposure to nitrous oxide did not enhance, but impaired, the recovery of enzyme activity.	1,3-dimethylthiourea	115-119	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	35-54
2480259-4	1989	Similarly, the cytotoxic effects of the cytokine combinations of interleukin 1 plus tumour necrosis factor, interferon gamma plus tumour necrosis factor, and interferon gamma plus interleukin 1 were significantly inhibited by the free radical scavenger combination of dimethylthiourea and citiolone.	1,3-dimethylthiourea	268-284	interferon gamma	Rattus norvegicus	108-124
2551876-3	1989	Although DMTU can also react with H2O2 in certain experimental systems, the effect of DMTU on the neutrophil myeloperoxidase (MPO) pathway has not been studied.	1,3-dimethylthiourea	86-90	myeloperoxidase	Homo sapiens	109-124
2551876-3	1989	Although DMTU can also react with H2O2 in certain experimental systems, the effect of DMTU on the neutrophil myeloperoxidase (MPO) pathway has not been studied.	1,3-dimethylthiourea	86-90	myeloperoxidase	Homo sapiens	126-129
2551876-5	1989	DMTU also provided complete inhibition when incubated with cell-free supernatants after the formation of the MPO products.	1,3-dimethylthiourea	0-4	myeloperoxidase	Homo sapiens	109-112
2551876-6	1989	DMTU prevented the oxidative inactivation of alpha 1-antitrypsin by neutrophil-stable oxidants.	1,3-dimethylthiourea	0-4	serpin family A member 1	Homo sapiens	45-64
2551876-7	1989	Evidence that DMTU was oxidized by the MPO products was obtained by titration of oxidized DMTU with reduced glutathione.	1,3-dimethylthiourea	14-18	myeloperoxidase	Homo sapiens	39-42
2551876-7	1989	Evidence that DMTU was oxidized by the MPO products was obtained by titration of oxidized DMTU with reduced glutathione.	1,3-dimethylthiourea	90-94	myeloperoxidase	Homo sapiens	39-42
2551876-9	1989	Metabolic studies with stimulated neutrophils and experiments with the MPO enzyme system in a cell-free system suggested that DMTU acts by scavenging the products of the MPO pathway rather than by blocking H2O2 production in the intact cell.	1,3-dimethylthiourea	126-130	myeloperoxidase	Homo sapiens	71-74
2551876-9	1989	Metabolic studies with stimulated neutrophils and experiments with the MPO enzyme system in a cell-free system suggested that DMTU acts by scavenging the products of the MPO pathway rather than by blocking H2O2 production in the intact cell.	1,3-dimethylthiourea	126-130	myeloperoxidase	Homo sapiens	170-173
2551876-10	1989	These findings demonstrate that DMTU blocks the neutrophil MPO pathway in addition to its known ability to scavenge other reactive O2 species.	1,3-dimethylthiourea	32-36	myeloperoxidase	Homo sapiens	59-62
2551876-11	1989	The capacity of DMTU to scavenge MPO products may explain some of its protective effects in acute lung injury.	1,3-dimethylthiourea	16-20	myeloperoxidase	Homo sapiens	33-36
2821829-3	1987	We found that addition of glucose oxidase (GO) or H2O2 to isolated perfused rat kidneys caused injury that was manifested by decreases in glomerular filtration rate, perfusion flow rate, and sodium reabsorption and that was prevented by addition of catalase (CAT) (but not inactivated CAT) or large doses of DMTU (15 mM), but not urea (15 mM).	1,3-dimethylthiourea	308-312	catalase	Rattus norvegicus	249-257
2607666-10	1989	So-called SOD mimics (Cu-complex etc), antioxidants (synthetic propyl gallate or natural flavonoids or tannins) and hydroxyl radical (.OH) scavengers such as DMTU (dimethylthiourea) are considered as a prototype for clinical application.	1,3-dimethylthiourea	158-162	superoxide dismutase 1	Homo sapiens	10-13
2607666-10	1989	So-called SOD mimics (Cu-complex etc), antioxidants (synthetic propyl gallate or natural flavonoids or tannins) and hydroxyl radical (.OH) scavengers such as DMTU (dimethylthiourea) are considered as a prototype for clinical application.	1,3-dimethylthiourea	164-180	superoxide dismutase 1	Homo sapiens	10-13
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	1,3-dimethylthiourea	176-180	catalase	Homo sapiens	252-260
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	1,3-dimethylthiourea	176-180	superoxide dismutase 1	Homo sapiens	270-273
2545552-2	1989	DMTU disappearance following reaction with H2O2 was inhibited by addition of catalase, but not aminotriazole-inactivated catalase (AMT-catalase), superoxide dismutase (SOD), mannitol, benzoate or dimethyl sulfoxide (DMSO) in vitro.	1,3-dimethylthiourea	0-4	catalase	Homo sapiens	77-85
2545552-5	1989	DMTU disappearance was also relatively specific for reaction with H2O2 in suspensions of endothelial cells where it was prevented by addition of catalase, but not AMT-catalase or SOD and did not occur following sonication or treatment with elastase, trypsin or leukotrienes.	1,3-dimethylthiourea	0-4	catalase	Homo sapiens	145-153
3130627-1	1988	We hypothesized that measurement of a specific product from reaction of N,N"-dimethylthiourea (Me2TU) and H2O2 would provide a good indication of the H2O2 scavenging and protection seen after addition of Me2TU to biological systems.	1,3-dimethylthiourea	72-93	malic enzyme 2	Homo sapiens	95-98
32367640-11	2020	To study the possibility that UT inhibition could benefit heart, we measured the mRNA of renin and angiotensin-converting enzyme (ACE), and found both were sharply increased in CKD heart; DMTU treatment and UT-KO significantly abolished these increases.	1,3-dimethylthiourea	188-192	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	99-128
2821995-3	1987	It is shown that both thiourea and dimethylthiourea are scavengers of HOCl, a powerful oxidant produced by neutrophil myeloperoxidase.	1,3-dimethylthiourea	35-51	myeloperoxidase	Homo sapiens	118-133
3018065-1	1985	Addition of increasing concentrations of hydrogen peroxide (H2O2) caused progressive decreases in dimethylthiourea (DMTU) concentrations which were inhibitable by simultaneous addition of catalase, but not the superoxide anion (O2-.)	1,3-dimethylthiourea	98-114	catalase	Homo sapiens	188-196
3018065-1	1985	Addition of increasing concentrations of hydrogen peroxide (H2O2) caused progressive decreases in dimethylthiourea (DMTU) concentrations which were inhibitable by simultaneous addition of catalase, but not the superoxide anion (O2-.)	1,3-dimethylthiourea	116-120	catalase	Homo sapiens	188-196
30222757-7	2018	H2O2 scavenger, dimethylthiourea (DMTU), effectively inhibited the Cu2+-increased H2O2 level and the activity of ZmMPK3 as well as the activities of the antioxidant enzymes SOD, CAT and APX.	1,3-dimethylthiourea	16-32	ascorbate peroxidase 2	Zea mays	186-189
32025801-10	2020	After treatment with H2O2, the effects of diphenyleneiodonium and or dimethylthiourea on proline content and activities of P5CS and ProDH were reversed.	1,3-dimethylthiourea	69-85	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	123-127
30222757-7	2018	H2O2 scavenger, dimethylthiourea (DMTU), effectively inhibited the Cu2+-increased H2O2 level and the activity of ZmMPK3 as well as the activities of the antioxidant enzymes SOD, CAT and APX.	1,3-dimethylthiourea	34-38	ascorbate peroxidase 2	Zea mays	186-189
29787990-6	2018	DMTU reduced ALT levels in ovx mice to the same levels as those in sham mice after CCl4 injection.	1,3-dimethylthiourea	0-4	glutamic pyruvic transaminase, soluble	Mus musculus	13-16
29787990-6	2018	DMTU reduced ALT levels in ovx mice to the same levels as those in sham mice after CCl4 injection.	1,3-dimethylthiourea	0-4	chemokine (C-C motif) ligand 4	Mus musculus	83-87
29787990-8	2018	DMTU significantly reduced cox-2 and iNOS expression levels upregulated by CCl4 in ovx mice.	1,3-dimethylthiourea	0-4	cytochrome c oxidase II, mitochondrial	Mus musculus	27-32
29787990-8	2018	DMTU significantly reduced cox-2 and iNOS expression levels upregulated by CCl4 in ovx mice.	1,3-dimethylthiourea	0-4	nitric oxide synthase 2, inducible	Mus musculus	37-41
29787990-8	2018	DMTU significantly reduced cox-2 and iNOS expression levels upregulated by CCl4 in ovx mice.	1,3-dimethylthiourea	0-4	chemokine (C-C motif) ligand 4	Mus musculus	75-79
26311287-11	2016	Both STS and DMTU suppressed ROS, phospho-ASK1, phospho-p38 MAPK and TF production, and ameliorated the microcirculatory disturbance and tissues injury (P <0.01).	1,3-dimethylthiourea	13-17	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	42-46
29426497-8	2018	In a test tube, N,N"-dimethylthiourea (DMTU) was the most efficient scavenger as compared to Trolox and N-Acethyl-L-cysteine, with NAC being the less effective.	1,3-dimethylthiourea	39-43	synuclein alpha	Homo sapiens	131-134
28107553-3	2017	DMTU (1, 2.5, or 5 mmol/kg) administered orally at 0.5 h before the onset of WIRS reduced the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner.	1,3-dimethylthiourea	0-4	myeloperoxidase	Rattus norvegicus	195-198
29029623-5	2017	Above responses were sensitive to the H2O2 scavenger (dimethylthiourea; DMTU) and the inhibitor of NADPH oxidase (diphenylene idonium; DPI), showing that the accumulations of H2O2 and increased RBOH1 transcript were respectively prevented.	1,3-dimethylthiourea	54-70	NADPH oxidase	Solanum lycopersicum	194-199
29029623-5	2017	Above responses were sensitive to the H2O2 scavenger (dimethylthiourea; DMTU) and the inhibitor of NADPH oxidase (diphenylene idonium; DPI), showing that the accumulations of H2O2 and increased RBOH1 transcript were respectively prevented.	1,3-dimethylthiourea	72-76	NADPH oxidase	Solanum lycopersicum	194-199
26311287-11	2016	Both STS and DMTU suppressed ROS, phospho-ASK1, phospho-p38 MAPK and TF production, and ameliorated the microcirculatory disturbance and tissues injury (P <0.01).	1,3-dimethylthiourea	13-17	coagulation factor III, tissue factor	Rattus norvegicus	69-71
24318675-10	2014	However, when the endogenous H2O2 level was inhibited by DPI or DMTU, the effect of H2S on the PM Na(+)/H(+) antiporter system was removed.	1,3-dimethylthiourea	64-68	Na+/H+ exchanger 1	Arabidopsis thaliana	98-119
26594223-10	2015	Moreover, AtSOT12 transcript level was elevated by treatments with DPI and DMTU, two chemicals preventing ROS accumulation.	1,3-dimethylthiourea	75-79	sulfotransferase 12	Arabidopsis thaliana	10-17
25515785-5	2015	Studies using an antioxidant (dimethylthiourea) indicated that the suppression of mitochondrial ROS completely abrogated the UA-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, as well as protection against menadione cytotoxicity in H9c2 cells.	1,3-dimethylthiourea	30-46	glutathione-disulfide reductase	Rattus norvegicus	180-201
25515785-5	2015	Studies using an antioxidant (dimethylthiourea) indicated that the suppression of mitochondrial ROS completely abrogated the UA-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, as well as protection against menadione cytotoxicity in H9c2 cells.	1,3-dimethylthiourea	30-46	glutathione-disulfide reductase	Rattus norvegicus	203-205
26545900-12	2016	OD induced an increase in total antioxidant capacity and mRNA levels of NRF-2-dependent antioxidant genes, effects that are prevented by administration of DMTU and neutrophil depletion.	1,3-dimethylthiourea	155-159	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-77
25993324-5	2015	DMTU fully and reversibly inhibited rat UT-A1 and UT-B by a noncompetitive mechanism with IC50 of 2-3 mM.	1,3-dimethylthiourea	0-4	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	50-54
25613743-2	2015	The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa recta endothelium) with IC50 of 2-3 mM, and was shown to have diuretic action when administered to rats.	1,3-dimethylthiourea	16-32	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	136-140
25613743-2	2015	The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa recta endothelium) with IC50 of 2-3 mM, and was shown to have diuretic action when administered to rats.	1,3-dimethylthiourea	34-38	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	136-140
23076873-7	2012	The AIH-augmented apneic response to these two stimulants was prevented by pretreatment with dimethylthiourea (a hydroxyl radical scavenger), N-acetyl-l-cysteine (an antioxidant) and HC-030031 [a transient receptor potential ankyrin 1 (TRPA1) receptor antagonist].	1,3-dimethylthiourea	93-109	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	196-234
24473214-4	2014	The suppression of mitochondrial ROS by the antioxidant dimethylthiourea abrogated the HCY2-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, and also protected against menadione-induced cytotoxicity.	1,3-dimethylthiourea	56-72	glutathione-disulfide reductase	Rattus norvegicus	144-165
24473214-4	2014	The suppression of mitochondrial ROS by the antioxidant dimethylthiourea abrogated the HCY2-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, and also protected against menadione-induced cytotoxicity.	1,3-dimethylthiourea	56-72	glutathione-disulfide reductase	Rattus norvegicus	167-169
24817286-12	2014	Interestingly, NAC and DMT reduced ROS production and suppressed p53 activation in renal cells exposed to cisplatin.	1,3-dimethylthiourea	23-26	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
23657856-8	2013	ANG II infusion into rats caused marked increases in glomerular permeability to large Ficoll molecules (Ficoll50-80A), which were abrogated by the ROS scavenger tempol and partly by DMTU.	1,3-dimethylthiourea	182-186	angiotensinogen	Rattus norvegicus	0-6
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	tumor necrosis factor	Mus musculus	38-47
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	BCL2-associated X protein	Mus musculus	49-52
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	FBJ osteosarcoma oncogene	Mus musculus	57-62
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	interleukin 6	Mus musculus	102-106
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	BCL2-like 1	Mus musculus	108-114
23384965-7	2013	DMTU reduced the expression levels of TNF-alpha, Bax and c-fos and increased the expression levels of IL-6, Bcl-xL and Nrf2 in WT mice.	1,3-dimethylthiourea	0-4	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
23384965-8	2013	Reduced reactive oxygen species (ROS) by DMTU resulted in increases of IL-6, anti-apoptosis and anti-oxidant gene expression levels.	1,3-dimethylthiourea	41-45	interleukin 6	Mus musculus	71-75
23384965-9	2013	In IL-6(-/-) mice, DMTU also improved cisplatin-induced renal dysfunction and reduced expression levels of TNF-alpha, Bax and c-fos, but not Bcl-xL and Nrf2.	1,3-dimethylthiourea	19-23	interleukin 6	Mus musculus	3-7
23384965-9	2013	In IL-6(-/-) mice, DMTU also improved cisplatin-induced renal dysfunction and reduced expression levels of TNF-alpha, Bax and c-fos, but not Bcl-xL and Nrf2.	1,3-dimethylthiourea	19-23	tumor necrosis factor	Mus musculus	107-116
23384965-9	2013	In IL-6(-/-) mice, DMTU also improved cisplatin-induced renal dysfunction and reduced expression levels of TNF-alpha, Bax and c-fos, but not Bcl-xL and Nrf2.	1,3-dimethylthiourea	19-23	BCL2-associated X protein	Mus musculus	118-121
23384965-9	2013	In IL-6(-/-) mice, DMTU also improved cisplatin-induced renal dysfunction and reduced expression levels of TNF-alpha, Bax and c-fos, but not Bcl-xL and Nrf2.	1,3-dimethylthiourea	19-23	FBJ osteosarcoma oncogene	Mus musculus	126-131
24631677-11	2014	The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea.	1,3-dimethylthiourea	136-157	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	18-23
24366686-6	2014	This conclusion was supported by analyzing the removal of H2O2 with ascorbic acid (AsA) and dimethylthiourea (DMTU), both of which could block NAA-induced HY1 expression and LR formation.	1,3-dimethylthiourea	92-108	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	155-158
24366686-6	2014	This conclusion was supported by analyzing the removal of H2O2 with ascorbic acid (AsA) and dimethylthiourea (DMTU), both of which could block NAA-induced HY1 expression and LR formation.	1,3-dimethylthiourea	110-114	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	155-158
24102363-5	2014	Treatment with dimethylthiourea (DMTU), a H(2)O(2) scavenger, suppressed HL- and VHL-induced CrMSRA3, CrMSRA5 and CrMSRB2.1 expression, whereas H(2)O(2) treatment stimulated the expression of these genes under 50 micromol photons m(-2)  s(-1) conditions (low light, LL).	1,3-dimethylthiourea	15-31	uncharacterized protein	Chlamydomonas reinhardtii	93-100
24102363-5	2014	Treatment with dimethylthiourea (DMTU), a H(2)O(2) scavenger, suppressed HL- and VHL-induced CrMSRA3, CrMSRA5 and CrMSRB2.1 expression, whereas H(2)O(2) treatment stimulated the expression of these genes under 50 micromol photons m(-2)  s(-1) conditions (low light, LL).	1,3-dimethylthiourea	15-31	uncharacterized protein	Chlamydomonas reinhardtii	102-109
24102363-5	2014	Treatment with dimethylthiourea (DMTU), a H(2)O(2) scavenger, suppressed HL- and VHL-induced CrMSRA3, CrMSRA5 and CrMSRB2.1 expression, whereas H(2)O(2) treatment stimulated the expression of these genes under 50 micromol photons m(-2)  s(-1) conditions (low light, LL).	1,3-dimethylthiourea	33-37	uncharacterized protein	Chlamydomonas reinhardtii	93-100
24102363-5	2014	Treatment with dimethylthiourea (DMTU), a H(2)O(2) scavenger, suppressed HL- and VHL-induced CrMSRA3, CrMSRA5 and CrMSRB2.1 expression, whereas H(2)O(2) treatment stimulated the expression of these genes under 50 micromol photons m(-2)  s(-1) conditions (low light, LL).	1,3-dimethylthiourea	33-37	uncharacterized protein	Chlamydomonas reinhardtii	102-109
24132784-9	2013	Reactive oxygen species scavenging through dimethylthiourea markedly alleviated the cotyledon-albino phenotypes of PRDA1 and MRL7 RNA interference seedlings.	1,3-dimethylthiourea	43-59	hypothetical protein	Arabidopsis thaliana	115-120
24132784-9	2013	Reactive oxygen species scavenging through dimethylthiourea markedly alleviated the cotyledon-albino phenotypes of PRDA1 and MRL7 RNA interference seedlings.	1,3-dimethylthiourea	43-59	polyadenylate-binding protein 2-binding protein	Arabidopsis thaliana	125-129
23522501-5	2013	Treatment with dimethylthiourea, a H2O2 scavenger, under VHL conditions reduced H2O2 production and PSY and PDS transcript levels and accelerated the reduction of carotenoids, the production of 1O2, viability loss and necrotic cell death.	1,3-dimethylthiourea	15-31	uncharacterized protein	Chlamydomonas reinhardtii	100-103
23076873-7	2012	The AIH-augmented apneic response to these two stimulants was prevented by pretreatment with dimethylthiourea (a hydroxyl radical scavenger), N-acetyl-l-cysteine (an antioxidant) and HC-030031 [a transient receptor potential ankyrin 1 (TRPA1) receptor antagonist].	1,3-dimethylthiourea	93-109	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	236-241
22227335-7	2012	PEG-catalase, DMTU or SC560 reduced the angiotensin II-induced contraction in diabetic rat carotid at the same extent.	1,3-dimethylthiourea	14-18	angiotensinogen	Rattus norvegicus	40-54
22692000-6	2012	Pre-treatment with the scavenger for H(2)O(2), dimethylthiourea (DMTU) and antioxidant, N-acetyl cysteine (NAC), effectively inhibited the activities of caspase-3 and caspase-9, eventually blocked Cd-induced DNA fragmentation and the appearance of markers for apoptotic cell death.	1,3-dimethylthiourea	47-63	caspase 3	Homo sapiens	153-162
22692000-6	2012	Pre-treatment with the scavenger for H(2)O(2), dimethylthiourea (DMTU) and antioxidant, N-acetyl cysteine (NAC), effectively inhibited the activities of caspase-3 and caspase-9, eventually blocked Cd-induced DNA fragmentation and the appearance of markers for apoptotic cell death.	1,3-dimethylthiourea	47-63	caspase 9	Homo sapiens	167-176
22692000-6	2012	Pre-treatment with the scavenger for H(2)O(2), dimethylthiourea (DMTU) and antioxidant, N-acetyl cysteine (NAC), effectively inhibited the activities of caspase-3 and caspase-9, eventually blocked Cd-induced DNA fragmentation and the appearance of markers for apoptotic cell death.	1,3-dimethylthiourea	65-69	caspase 3	Homo sapiens	153-162
22692000-6	2012	Pre-treatment with the scavenger for H(2)O(2), dimethylthiourea (DMTU) and antioxidant, N-acetyl cysteine (NAC), effectively inhibited the activities of caspase-3 and caspase-9, eventually blocked Cd-induced DNA fragmentation and the appearance of markers for apoptotic cell death.	1,3-dimethylthiourea	65-69	caspase 9	Homo sapiens	167-176
20430163-6	2010	The capillary filtration coefficient (P<.01), LW/BW (P<.01) and PCBAL (P<.05) were significantly lower among the DMTU-treated rats than hosts pretreated with SOD or CAT.	1,3-dimethylthiourea	122-126	catalase	Rattus norvegicus	174-177
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	dual oxidase 1	Homo sapiens	86-91
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	epidermal growth factor receptor	Homo sapiens	93-97
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	103-109
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	dual oxidase 1	Homo sapiens	143-148
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	epidermal growth factor receptor	Homo sapiens	152-156
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	epidermal growth factor receptor	Homo sapiens	152-156
21984036-8	2012	Pretreatment with DMTU resulted in a significant decrease in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC when compared with the PMA group (all P < 0.01).	1,3-dimethylthiourea	18-22	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	168-174
20925946-10	2010	4-Hydroxynonenal analysis showed that DMTU given pre- or post-Cl2 prevented lipid peroxidation in the lung.	1,3-dimethylthiourea	38-42	doublecortin-like kinase 2	Mus musculus	62-65
20925946-11	2010	Following Cl2 exposure glutathione (GSH) was elevated immediately following exposure both in BAL cells and in fluid and this change was prevented by DMTU.	1,3-dimethylthiourea	149-153	doublecortin-like kinase 2	Mus musculus	10-13
20925946-14	2010	CONCLUSION: Our data show that the anti-oxidant DMTU is effective in attenuating Cl2 induced increase in airway responsiveness, inflammation and biomarkers of oxidative stress.	1,3-dimethylthiourea	48-52	doublecortin-like kinase 2	Mus musculus	81-84
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	dual oxidase 1	Homo sapiens	113-118
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	epidermal growth factor receptor	Homo sapiens	120-124
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	130-136
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	dual oxidase 1	Homo sapiens	170-175
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	epidermal growth factor receptor	Homo sapiens	179-183
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	epidermal growth factor receptor	Homo sapiens	179-183
21984036-9	2012	When cells were pretreated with both heparin and DMTU, there was a further reduction in ROS content, the mRNA of Duox1, EGFR, and MUC5AC as well as the protein levels of Duox1, p-EGFR, EGFR, and MUC5AC, when compared with either the PMA group, heparin group, or DMTU group (all P < 0.01).	1,3-dimethylthiourea	49-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	195-201
21525184-7	2011	The role of ROS in inducing STAT3 activation was assessed by administration of the ROS scavenger dimethylthiourea (DMTU).	1,3-dimethylthiourea	97-113	signal transducer and activator of transcription 3	Rattus norvegicus	28-33
21525184-7	2011	The role of ROS in inducing STAT3 activation was assessed by administration of the ROS scavenger dimethylthiourea (DMTU).	1,3-dimethylthiourea	115-119	signal transducer and activator of transcription 3	Rattus norvegicus	28-33
21525184-11	2011	In addition, DMTU suppressed STAT3 activation in a dose-dependent manner, indicating that STAT3 activation may be a subsequent event after ROS production.	1,3-dimethylthiourea	13-17	signal transducer and activator of transcription 3	Rattus norvegicus	29-34
21525184-11	2011	In addition, DMTU suppressed STAT3 activation in a dose-dependent manner, indicating that STAT3 activation may be a subsequent event after ROS production.	1,3-dimethylthiourea	13-17	signal transducer and activator of transcription 3	Rattus norvegicus	90-95
19059812-6	2009	Inflammatory response was completely abolished by pretreatment alone with dimethylthiourea (DMTU), a hydroxyl radical scavenger, and was also attenuated by pretreatment with L-732,138, a NK1 receptor antagonist.	1,3-dimethylthiourea	74-90	tachykinin receptor 1	Rattus norvegicus	187-199
19633204-7	2009	In chronic diabetic rats, DMTU markedly attenuated the impairment in Q(maxad) and normalized the expression of MEF-2 and eHAND and MHC isoform composition but exerted an insignificant benefit on E(maxn).	1,3-dimethylthiourea	26-30	heart and neural crest derivatives expressed 1	Rattus norvegicus	121-126
19633204-10	2009	The advantage of DMTU in chronic diabetic rats might involve normalization of MEF-2 and eHAND, as well as reversal of MHC isoform switch.	1,3-dimethylthiourea	17-21	heart and neural crest derivatives expressed 1	Rattus norvegicus	88-93
19059812-6	2009	Inflammatory response was completely abolished by pretreatment alone with dimethylthiourea (DMTU), a hydroxyl radical scavenger, and was also attenuated by pretreatment with L-732,138, a NK1 receptor antagonist.	1,3-dimethylthiourea	92-96	tachykinin receptor 1	Rattus norvegicus	187-199
18992762-4	2009	DMTU significantly inhibited the CDDP-induced increments of serum creatinine, the number of 8-hydroxyl-2"-deoxyguanosine (8-OHdG)- and terminal deoxynucleotidyl transferase nick-end labeling (TUNEL)-positive tubular cells, and tubular damage score (p<0.05).	1,3-dimethylthiourea	0-4	DNA nucleotidylexotransferase	Homo sapiens	135-172
18992762-6	2009	DMTU significantly augmented only the expression of HSP60 expression mainly in the cytoplasm of the proximal tubular cells at days 1 and 3 in CDDP-induced ARF.	1,3-dimethylthiourea	0-4	heat shock protein family D (Hsp60) member 1	Homo sapiens	52-57
18992762-7	2009	DMTU also inhibited the CDDP-induced increment of Bax, a pro-apoptotic protein, in the fraction of organelles/membranes at day 3.	1,3-dimethylthiourea	0-4	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
18992762-8	2009	The findings suggest that DMTU may afford protection against CDDP-induced ARF, partially through the early induction of cytoplasmic HSP60, thereby preventing the Bax-mediated apoptosis in renal tubular cells.	1,3-dimethylthiourea	26-30	heat shock protein family D (Hsp60) member 1	Homo sapiens	132-137
18992762-8	2009	The findings suggest that DMTU may afford protection against CDDP-induced ARF, partially through the early induction of cytoplasmic HSP60, thereby preventing the Bax-mediated apoptosis in renal tubular cells.	1,3-dimethylthiourea	26-30	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
18773185-6	2008	The free radical scavenger DMTU eliminated Ang II-induced cell migration, ERM protein phosphorylation and cortical F-actin remodeling, indicating that ROS mediates the influence of Rac-1 on podocyte AT1R signaling.	1,3-dimethylthiourea	27-31	angiotensinogen	Rattus norvegicus	43-49
18773185-6	2008	The free radical scavenger DMTU eliminated Ang II-induced cell migration, ERM protein phosphorylation and cortical F-actin remodeling, indicating that ROS mediates the influence of Rac-1 on podocyte AT1R signaling.	1,3-dimethylthiourea	27-31	Rac family small GTPase 1	Rattus norvegicus	181-186
18773185-6	2008	The free radical scavenger DMTU eliminated Ang II-induced cell migration, ERM protein phosphorylation and cortical F-actin remodeling, indicating that ROS mediates the influence of Rac-1 on podocyte AT1R signaling.	1,3-dimethylthiourea	27-31	angiotensin II receptor, type 1a	Rattus norvegicus	199-203
17360948-5	2007	The light chain-mediated effect on MCP-1 production was inhibited by co-incubation with 1,3-dimethyl-2-thiourea, which also inhibited lactate dehydrogenase release, and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB.	1,3-dimethylthiourea	88-111	C-C motif chemokine ligand 2	Homo sapiens	35-40
17620452-6	2007	Pretreatment of cells with the antioxidant enzyme catalase and the intracellular hydroxyl scavenger dimethylthiourea (DMTU) abrogated the thalidomide-induced p38 MAPK activation and histone H4 acetylation.	1,3-dimethylthiourea	100-116	mitogen-activated protein kinase 14	Homo sapiens	158-161
17620452-6	2007	Pretreatment of cells with the antioxidant enzyme catalase and the intracellular hydroxyl scavenger dimethylthiourea (DMTU) abrogated the thalidomide-induced p38 MAPK activation and histone H4 acetylation.	1,3-dimethylthiourea	118-122	mitogen-activated protein kinase 14	Homo sapiens	158-161
17529908-3	2007	The antioxidants dimethyl sulfoxide (DMSO), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS)-induced MCP-1 production in either whole blood or isolated blood cells.	1,3-dimethylthiourea	67-84	C-C motif chemokine ligand 2	Homo sapiens	142-147
17291459-7	2007	Dimethylthiourea (DMTU) and N-acetyl-cysteine (NAC) attenuated hydroxyl radical accumulation, and importantly, diminished p53 activation during cisplatin treatment.	1,3-dimethylthiourea	0-16	transformation related protein 53, pseudogene	Mus musculus	122-125
17291459-7	2007	Dimethylthiourea (DMTU) and N-acetyl-cysteine (NAC) attenuated hydroxyl radical accumulation, and importantly, diminished p53 activation during cisplatin treatment.	1,3-dimethylthiourea	18-22	transformation related protein 53, pseudogene	Mus musculus	122-125
17291459-10	2007	Notably, DMTU and NAC, when added post-cisplatin treatment, were also inhibitory to p53 activation and apoptosis.	1,3-dimethylthiourea	9-13	transformation related protein 53, pseudogene	Mus musculus	84-87
17291459-11	2007	In C57BL/6 mice, cisplatin at 30 mg/kg induced p53 phosphorylation and protein accumulation, which was also abrogated by DMTU.	1,3-dimethylthiourea	121-125	transformation related protein 53, pseudogene	Mus musculus	47-50
18218988-9	2008	The oxidative scavenger DMTU decreased the neutrophil CD66b expression by 36%.	1,3-dimethylthiourea	24-28	CEA cell adhesion molecule 8	Homo sapiens	54-59
17360948-5	2007	The light chain-mediated effect on MCP-1 production was inhibited by co-incubation with 1,3-dimethyl-2-thiourea, which also inhibited lactate dehydrogenase release, and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB.	1,3-dimethylthiourea	88-111	nuclear factor kappa B subunit 1	Homo sapiens	217-226
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	1,3-dimethylthiourea	102-118	tumor necrosis factor	Homo sapiens	135-143
17222881-3	2007	N-Acetyl-l-cysteine (20 mM), dimethyl thiourea (20 mM) and catalase (5 microM) significantly inhibited TNF release by primed AMs incubated with CAPs.	1,3-dimethylthiourea	29-46	tumor necrosis factor	Homo sapiens	103-106
16485119-8	2006	Protection of rats against cisplatin-induced ARF by dimethylthiourea, a hydroxyl radical scavenger, also protected rats against the decrease in serum testosterone levels and the down-regulation of CYP2C11 and CYP3A2.	1,3-dimethylthiourea	52-68	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	197-204
16485119-8	2006	Protection of rats against cisplatin-induced ARF by dimethylthiourea, a hydroxyl radical scavenger, also protected rats against the decrease in serum testosterone levels and the down-regulation of CYP2C11 and CYP3A2.	1,3-dimethylthiourea	52-68	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	209-215
15795323-5	2005	TNF-alpha induction was also inhibited by tempol, N-acetylcysteine, or 1,3-dimethyl-2-thiourea.	1,3-dimethylthiourea	71-94	tumor necrosis factor	Mus musculus	0-9
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	1,3-dimethylthiourea	103-119	tumor necrosis factor	Mus musculus	153-162
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	1,3-dimethylthiourea	103-119	chemokine (C-C motif) ligand 2	Mus musculus	171-176
14975589-6	2004	On the other hand, free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuated morphine and gp160-induced human monocyte apoptosis.	1,3-dimethylthiourea	79-95	glutamyl aminopeptidase	Homo sapiens	140-145
14975589-6	2004	On the other hand, free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuated morphine and gp160-induced human monocyte apoptosis.	1,3-dimethylthiourea	97-101	glutamyl aminopeptidase	Homo sapiens	140-145
14569496-7	2003	DMTU pretreatment inhibited ROFA-induced pulmonary inflammation, cytotoxicity, ERK MAPK activation, and cytokine gene expression.	1,3-dimethylthiourea	0-4	Eph receptor B1	Rattus norvegicus	79-82
16899518-9	2006	Treatment with DMTU prevented the increased heparanase expression, the loss of GBM HS, and reduced albuminuria.	1,3-dimethylthiourea	15-19	heparanase	Rattus norvegicus	44-54
16899518-12	2006	The effects of DMTU suggest a role for reactive oxygen species in upregulation of heparanase.	1,3-dimethylthiourea	15-19	heparanase	Rattus norvegicus	82-92
15701814-14	2005	The hydroxyl radical scavenger DMTU (100 mg.kg body wt(-1).day(-1)) prevented the activation of p38 MAPK by cisplatin both in vitro and in vivo.	1,3-dimethylthiourea	31-35	mitogen-activated protein kinase 14	Mus musculus	96-99
15701814-15	2005	DMTU also completely prevented cisplatin-induced renal injury (BUN: 140 +/- 27 vs. 22 +/- 2 mg/dl, P < 0.005) and the increase in serum TNF-alpha (33 +/- 7 vs. 4 +/- 2 pg/ml, P < 0.005) and kidney TNF-alpha mRNA in vivo.	1,3-dimethylthiourea	0-4	tumor necrosis factor	Mus musculus	139-148
15701814-15	2005	DMTU also completely prevented cisplatin-induced renal injury (BUN: 140 +/- 27 vs. 22 +/- 2 mg/dl, P < 0.005) and the increase in serum TNF-alpha (33 +/- 7 vs. 4 +/- 2 pg/ml, P < 0.005) and kidney TNF-alpha mRNA in vivo.	1,3-dimethylthiourea	0-4	tumor necrosis factor	Mus musculus	203-212
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	1,3-dimethylthiourea	222-238	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	1,3-dimethylthiourea	222-238	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15378141-13	2004	Antioxidants (superoxide dismutase, catalase, and dimethylthiourea) blocked CRP-induced oxygen radicals by WBCs.	1,3-dimethylthiourea	50-66	C-reactive protein	Homo sapiens	76-79
15207648-10	2004	Induction of HO-1 by Pb2+ is reduced by the hydroxyl radical scavengers dimethylthiourea (DMTU) and mannitol, but not by inhibitors of calmodulin, calmodulin-dependent protein kinases, protein kinase C, or extracellular signal-regulated kinases (ERK).	1,3-dimethylthiourea	72-88	heme oxygenase 1	Homo sapiens	13-17
15207648-10	2004	Induction of HO-1 by Pb2+ is reduced by the hydroxyl radical scavengers dimethylthiourea (DMTU) and mannitol, but not by inhibitors of calmodulin, calmodulin-dependent protein kinases, protein kinase C, or extracellular signal-regulated kinases (ERK).	1,3-dimethylthiourea	90-94	heme oxygenase 1	Homo sapiens	13-17
14630611-5	2004	Treating CAP suspensions with 20 microM deferoxamine or 2 mM dimethylthiourea attenuated the enhancement, indicating that transition metals and oxidative stress participate in the CAPs-dependent IL-8 response of primed cells.	1,3-dimethylthiourea	61-77	chemokine (C-X-C motif) ligand 15	Mus musculus	195-199
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	1,3-dimethylthiourea	102-118	intercellular adhesion molecule 1	Homo sapiens	152-158
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	1,3-dimethylthiourea	120-124	tumor necrosis factor	Homo sapiens	135-143
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	1,3-dimethylthiourea	120-124	intercellular adhesion molecule 1	Homo sapiens	152-158
14572618-6	2003	Surprisingly, either PDTC or DMTU inhibited the binding of TNFalpha-enhanced C/EBP complexes to the consensus site directly adjacent to the NFkappaB site.	1,3-dimethylthiourea	29-33	tumor necrosis factor	Homo sapiens	59-67
14572618-6	2003	Surprisingly, either PDTC or DMTU inhibited the binding of TNFalpha-enhanced C/EBP complexes to the consensus site directly adjacent to the NFkappaB site.	1,3-dimethylthiourea	29-33	CCAAT enhancer binding protein alpha	Homo sapiens	77-82
14572618-6	2003	Surprisingly, either PDTC or DMTU inhibited the binding of TNFalpha-enhanced C/EBP complexes to the consensus site directly adjacent to the NFkappaB site.	1,3-dimethylthiourea	29-33	nuclear factor kappa B subunit 1	Homo sapiens	140-148
12428016-3	2002	Supporting this hypothesis, our results show that the antioxidants dimethylthiourea (DMTU) and 3-t-butyl-4-hydroxy-anizole (BHA) inhibit the SA-induced transcription of genes controlled by as-1 elements in tobacco (Nicotiana tabacum) plants [i.e. GNT35 gene coding for a GST and (as-1)(4)/beta-glucuronidase (GUS) reporter transgene].	1,3-dimethylthiourea	67-83	glutathione S-transferase	Nicotiana tabacum	271-274
12428016-3	2002	Supporting this hypothesis, our results show that the antioxidants dimethylthiourea (DMTU) and 3-t-butyl-4-hydroxy-anizole (BHA) inhibit the SA-induced transcription of genes controlled by as-1 elements in tobacco (Nicotiana tabacum) plants [i.e. GNT35 gene coding for a GST and (as-1)(4)/beta-glucuronidase (GUS) reporter transgene].	1,3-dimethylthiourea	85-89	glutathione S-transferase	Nicotiana tabacum	271-274
11976274-9	2002	In SHR chronically treated with dimethylthiourea endothelium-dependent contractions to acetylcholine were decreased, and reduced further by acute in vitro exposure to deferoxamine or the combination of superoxide dismutase plus catalase.	1,3-dimethylthiourea	32-48	catalase	Rattus norvegicus	228-236
11493611-6	2001	Administration of dimethylthiourea, desferrioxamine, or N-acetylcysteine provoked significant reductions in Ang-II-induced leukocyte-endothelial cell interactions.	1,3-dimethylthiourea	18-34	angiotensinogen	Rattus norvegicus	108-114
11961005-7	2002	The contribution of H(2)O(2) in regulating NF-kappaB activation was evaluated by using the antioxidants dimethyl-thiourea and pyrrolidine dithiocarbamate in protein-overloaded HK-2 cells.	1,3-dimethylthiourea	104-121	nuclear factor kappa B subunit 1	Homo sapiens	43-52
11919081-9	2002	Dimethylthiourea also inhibited the neutrophil elastase (NE)-induced increase in MUC5AC expression in normal human bronchial epithelial cells.	1,3-dimethylthiourea	0-16	elastase, neutrophil expressed	Homo sapiens	36-55
11919081-9	2002	Dimethylthiourea also inhibited the neutrophil elastase (NE)-induced increase in MUC5AC expression in normal human bronchial epithelial cells.	1,3-dimethylthiourea	0-16	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	81-87
12097831-4	2002	In OK cells subjected to chemical hypoxia, the generation of ROS was increased, and this was prevented by the H(2)O(2) scavenger catalase, but not by the hydroxyl radical scavenger dimethylthiourea (DMTU).	1,3-dimethylthiourea	199-203	catalase	Oryctolagus cuniculus	129-137
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	48-71	interleukin 1 beta	Homo sapiens	177-186
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	48-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-206
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	73-77	interleukin 1 beta	Homo sapiens	177-186
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	73-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-206
11752025-8	2002	The ROS scavengers dimethyl-thio-urea and pyrrolidone-dithio-carbamate strongly inhibited increased GM-CSF production induced by ROS.	1,3-dimethylthiourea	19-37	colony stimulating factor 2	Homo sapiens	100-106
11752025-11	2002	Dimethyl-thio-urea significantly inhibited the LPS-, IL-1-, and PMA-induced GM-CSF production.	1,3-dimethylthiourea	0-18	interleukin 1 alpha	Homo sapiens	53-57
11752025-11	2002	Dimethyl-thio-urea significantly inhibited the LPS-, IL-1-, and PMA-induced GM-CSF production.	1,3-dimethylthiourea	0-18	colony stimulating factor 2	Homo sapiens	76-82
11603923-5	2001	Pretreatment of HUVECs with antioxidants, catalase (300 U/ml) or 1,3-dimethyl-2-thiourea (DMTU, 0.1 mm), abolished the strain-induced Et-1 release.	1,3-dimethylthiourea	65-88	endothelin 1	Homo sapiens	134-138
11603923-5	2001	Pretreatment of HUVECs with antioxidants, catalase (300 U/ml) or 1,3-dimethyl-2-thiourea (DMTU, 0.1 mm), abolished the strain-induced Et-1 release.	1,3-dimethylthiourea	90-94	endothelin 1	Homo sapiens	134-138
11466560-8	2001	Coadministration of the radical scavenger dimethylthiourea abolished this ANG II mediated p27(Kip1) expression without reducing systemic blood pressure.	1,3-dimethylthiourea	42-58	angiotensinogen	Rattus norvegicus	74-80
11466560-8	2001	Coadministration of the radical scavenger dimethylthiourea abolished this ANG II mediated p27(Kip1) expression without reducing systemic blood pressure.	1,3-dimethylthiourea	42-58	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	90-93
11466560-8	2001	Coadministration of the radical scavenger dimethylthiourea abolished this ANG II mediated p27(Kip1) expression without reducing systemic blood pressure.	1,3-dimethylthiourea	42-58	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	94-98
11466560-9	2001	Furthermore, dimethylthiourea infusion attenuates the ANG II mediated G(1)-phase arrest of tubular cells.	1,3-dimethylthiourea	13-29	angiotensinogen	Rattus norvegicus	54-60
11207678-6	2001	Addition of dimethylthiourea or mannitol + methionine, two *OH scavengers, resulted in a significant protection of ACE activity.	1,3-dimethylthiourea	12-28	angiotensin I converting enzyme	Homo sapiens	115-118
10448903-8	1999	DMTU also inhibited preconditioning mediated increased phosphorylation of p38 MAP kinase and MAPKAP kinase 2 activity.	1,3-dimethylthiourea	0-4	mitogen activated protein kinase 14	Rattus norvegicus	74-88
11162780-8	2001	Furthermore, coincubation of 2 mM nickel subsulfide with catalase, dimethylthiourea, mannitol, or vitamin C at 37 degrees C for 2 h resulted in a significant decrease of nickel subsulfide-induced formation of DPXLs, suggesting that nickel subsulfide-induced DPXLs formation in isolated rat lymphocytes is caused by the formation of ROS.	1,3-dimethylthiourea	67-83	catalase	Rattus norvegicus	57-65
11053978-4	2001	The free radical scavengers, dimethylthiourea and N-acetylcysteine inhibited HB-EGF mRNA induction.	1,3-dimethylthiourea	29-45	heparin-binding EGF-like growth factor	Rattus norvegicus	77-83
11053552-5	2000	On individual immediate cotreatment, some molecules exhibited selective protection against only one mustard, such as DMTU and WR-1065 against HN2 and DOX against SM, whereas NAC and L-TC were effective against both SM and HN2 cytotoxicity.	1,3-dimethylthiourea	117-121	MT-RNR2 like 2 (pseudogene)	Homo sapiens	142-145
11053552-5	2000	On individual immediate cotreatment, some molecules exhibited selective protection against only one mustard, such as DMTU and WR-1065 against HN2 and DOX against SM, whereas NAC and L-TC were effective against both SM and HN2 cytotoxicity.	1,3-dimethylthiourea	117-121	MT-RNR2 like 2 (pseudogene)	Homo sapiens	222-225
26368636-7	2000	Dimethylthiourea (DMTU), an antioxidant, inhibited the NF-kappaB DNA binding induced by DEP, suggesting an involvement of reactive oxygen species (ROS) in the transduction pathways leading to NF-kappaB activation.	1,3-dimethylthiourea	0-16	nuclear factor kappa B subunit 1	Homo sapiens	55-64
26368636-7	2000	Dimethylthiourea (DMTU), an antioxidant, inhibited the NF-kappaB DNA binding induced by DEP, suggesting an involvement of reactive oxygen species (ROS) in the transduction pathways leading to NF-kappaB activation.	1,3-dimethylthiourea	0-16	nuclear factor kappa B subunit 1	Homo sapiens	192-201
26368636-7	2000	Dimethylthiourea (DMTU), an antioxidant, inhibited the NF-kappaB DNA binding induced by DEP, suggesting an involvement of reactive oxygen species (ROS) in the transduction pathways leading to NF-kappaB activation.	1,3-dimethylthiourea	18-22	nuclear factor kappa B subunit 1	Homo sapiens	55-64
26368636-7	2000	Dimethylthiourea (DMTU), an antioxidant, inhibited the NF-kappaB DNA binding induced by DEP, suggesting an involvement of reactive oxygen species (ROS) in the transduction pathways leading to NF-kappaB activation.	1,3-dimethylthiourea	18-22	nuclear factor kappa B subunit 1	Homo sapiens	192-201
10562909-12	1999	Dimethylthiourea abolished the increase elaboration of u-PA induced by TNF completely, catalase did so partially, and SOD did not do so at all.	1,3-dimethylthiourea	0-16	plasminogen activator, urokinase	Homo sapiens	55-59
10562909-12	1999	Dimethylthiourea abolished the increase elaboration of u-PA induced by TNF completely, catalase did so partially, and SOD did not do so at all.	1,3-dimethylthiourea	0-16	tumor necrosis factor	Homo sapiens	71-74
11291601-4	2001	Specifically, we hypothesized that DMTU would prolong graft survival and decrease activation of nuclear factor-kappa B (NF-kappa B), an important redox-sensitive transcription factor necessary for iNOS gene expression.	1,3-dimethylthiourea	35-39	nuclear factor kappa B subunit 1	Homo sapiens	96-118
11291601-4	2001	Specifically, we hypothesized that DMTU would prolong graft survival and decrease activation of nuclear factor-kappa B (NF-kappa B), an important redox-sensitive transcription factor necessary for iNOS gene expression.	1,3-dimethylthiourea	35-39	nuclear factor kappa B subunit 1	Homo sapiens	120-130
11291601-4	2001	Specifically, we hypothesized that DMTU would prolong graft survival and decrease activation of nuclear factor-kappa B (NF-kappa B), an important redox-sensitive transcription factor necessary for iNOS gene expression.	1,3-dimethylthiourea	35-39	nitric oxide synthase 2	Homo sapiens	197-201
11128050-12	2000	DMTU and TMTU attenuated (P < 0.001) the MC + IgGAg-induced migration of Mphi as well as IgGAg-induced mRNA expression for RANTES and MCP-1.	1,3-dimethylthiourea	0-4	C-C motif chemokine ligand 5	Homo sapiens	126-132
11128050-12	2000	DMTU and TMTU attenuated (P < 0.001) the MC + IgGAg-induced migration of Mphi as well as IgGAg-induced mRNA expression for RANTES and MCP-1.	1,3-dimethylthiourea	0-4	C-C motif chemokine ligand 2	Homo sapiens	137-142
10969037-9	2000	Myocardial matrix metalloproteinase-2 activity, measured with gelatin zymography, was increased with MI after 7 and 28 days, which was attenuated in MI+DMTU.	1,3-dimethylthiourea	152-156	matrix metallopeptidase 2	Mus musculus	11-37
10843967-6	2000	DMTU inhibited NE-induced MUC5AC expression.	1,3-dimethylthiourea	0-4	elastase, neutrophil expressed	Homo sapiens	15-17
10843967-6	2000	DMTU inhibited NE-induced MUC5AC expression.	1,3-dimethylthiourea	0-4	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	26-32
10640773-5	2000	Neutrophil supernatant-induced EGFR tyrosine phosphorylation, activation of p44/42mapk, and MUC5AC synthesis were inhibited by antioxidants (N-acetyl-cysteine, DMSO, dimethyl thiourea, or superoxide dismutase); neutralizing Abs to EGFR ligands (EGF and TGF-alpha) were without effect, and no TGF-alpha protein was found in the neutrophil supernatant.	1,3-dimethylthiourea	166-183	epidermal growth factor receptor	Homo sapiens	31-35
10461466-9	1999	In both cases pretreatment with the antioxidant dimethylthiourea (DMTU) prevented rhodopsin and photoreceptor cell DNA loss.	1,3-dimethylthiourea	48-64	rhodopsin	Rattus norvegicus	82-91
10461466-9	1999	In both cases pretreatment with the antioxidant dimethylthiourea (DMTU) prevented rhodopsin and photoreceptor cell DNA loss.	1,3-dimethylthiourea	66-70	rhodopsin	Rattus norvegicus	82-91
10381206-5	1999	In the case of mant-GTP, protection from peroxynitrite-mediated oxidation was observed in the presence of the free radical scavengers, mannitol and DMTU.	1,3-dimethylthiourea	148-152	mitochondrial ribosome associated GTPase 1	Homo sapiens	15-23
10025958-5	1999	This activation of AP-1 was inhibited by a scavenger of oxygen free radicals, DMTU.	1,3-dimethylthiourea	78-82	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-23
10190572-11	1999	DMT, DET or TMT enhanced CCl4-induced liver toxicity, as monitored by plasma aminotransferase activity, although each of the agents alone caused only slight increase in the alanine aminotransferase activity.	1,3-dimethylthiourea	0-3	C-C motif chemokine ligand 4	Rattus norvegicus	25-29
9761743-8	1998	DSF and DMTU reduced the induction of PCK mRNA to about half-maximal and increased the induction of GK mRNA to maximal under both O2 tensions.	1,3-dimethylthiourea	8-12	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	38-41
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	1,3-dimethylthiourea	162-178	interleukin 1 beta	Homo sapiens	73-82
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	1,3-dimethylthiourea	162-178	tumor necrosis factor	Homo sapiens	87-96
9761743-8	1998	DSF and DMTU reduced the induction of PCK mRNA to about half-maximal and increased the induction of GK mRNA to maximal under both O2 tensions.	1,3-dimethylthiourea	8-12	glucokinase	Rattus norvegicus	100-102
9614211-3	1998	The uptake of acetylated low density lipoprotein and the levels of MSR-I mRNA were inhibited by treatment with the oxygen radical scavengers 2,2,6, 6-tetramethylpiperidine-N-oxyl, dimethylthiourea or sodium benzoate, or the iron chelator deferoxamine.	1,3-dimethylthiourea	180-196	progestin and adipoQ receptor family member 7	Homo sapiens	67-70
9620069-14	1998	Photoreceptor cell loss determined by biochemical measurement, DNA fragmentation, and HO-1 induction were dramatically reduced by the administration of DMTU.	1,3-dimethylthiourea	152-156	heme oxygenase 1	Rattus norvegicus	86-90
9749156-8	1998	Addition of dimethylthiourea (DMTU: 0.03 to 1 mM) or mannitol + methionine (20/10 mM), two sets of .OH scavengers, produced a dose-dependent protection on ACE activity.	1,3-dimethylthiourea	12-28	angiotensin I converting enzyme	Homo sapiens	155-158
9749156-8	1998	Addition of dimethylthiourea (DMTU: 0.03 to 1 mM) or mannitol + methionine (20/10 mM), two sets of .OH scavengers, produced a dose-dependent protection on ACE activity.	1,3-dimethylthiourea	30-34	angiotensin I converting enzyme	Homo sapiens	155-158
9626987-5	1998	The beneficial effect of DMTU, a hydroxyl radical scavenger, was associated with less accumulation of MDA, less tubular damage, and enhanced expression of proliferating cell nuclear antigen (PCNA) in the damaged tubular cells, but not with improvement of reduced renal blood flow (RBF).	1,3-dimethylthiourea	25-29	proliferating cell nuclear antigen	Rattus norvegicus	155-189
9626987-5	1998	The beneficial effect of DMTU, a hydroxyl radical scavenger, was associated with less accumulation of MDA, less tubular damage, and enhanced expression of proliferating cell nuclear antigen (PCNA) in the damaged tubular cells, but not with improvement of reduced renal blood flow (RBF).	1,3-dimethylthiourea	25-29	proliferating cell nuclear antigen	Rattus norvegicus	191-195
9614211-4	1998	Dimethylthiourea or benzoate also decreased the levels of MSR-I mRNA in the presence of the transcription inhibitor actinomycin D.	1,3-dimethylthiourea	0-16	progestin and adipoQ receptor family member 7	Homo sapiens	58-61
9545259-7	1998	UT3-mediated water and urea transport were weakly temperature-dependent (activation energy <4 kcal/mol), inhibited > 75% by the urea transport inhibitor 1,3-dimethylthiourea, but not inhibited by the water transport inhibitor HgCl2.	1,3-dimethylthiourea	159-179	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	0-3
9605436-5	1998	Agents known to decrease the production of reactive oxygen species such as dimethylthiourea and o-phenanthroline prevented the increase in SSAT activity indicating ROS involvement in the induction process.	1,3-dimethylthiourea	75-91	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	139-143
9251245-9	1997	Co-treatment with DMTU prevented MCT-induced cytotoxicity, alterations in TN distribution and content, and reduced the increase in DCF fluorescence.	1,3-dimethylthiourea	18-22	tenascin C	Homo sapiens	74-76
9357851-4	1997	Treatment with the antioxidant 1,3-dimethyl-2-thiourea (10 mM) or the iron chelator deferoxamine (1.8 microM) doubles basal ET-1 release.	1,3-dimethylthiourea	31-54	endothelin 1	Rattus norvegicus	124-128
9190883-7	1997	Rebamipide 2 mM was as effective as 20 mM of dimethylthiourea, a known hydroxyl radical scavenger, in inhibiting the increase in lipid peroxides, transforming growth factor-beta1, fibronectin mRNAs and proteins induced by incubation of cultured mesangial cells with high glucose.	1,3-dimethylthiourea	45-61	transforming growth factor, beta 1	Rattus norvegicus	146-178
9190883-7	1997	Rebamipide 2 mM was as effective as 20 mM of dimethylthiourea, a known hydroxyl radical scavenger, in inhibiting the increase in lipid peroxides, transforming growth factor-beta1, fibronectin mRNAs and proteins induced by incubation of cultured mesangial cells with high glucose.	1,3-dimethylthiourea	45-61	fibronectin 1	Rattus norvegicus	180-191
9104891-0	1997	Dimethylthiourea protects rats against gram-negative sepsis and decreases tumor necrosis factor and nuclear factor kappaB activity.	1,3-dimethylthiourea	0-16	tumor necrosis factor-like	Rattus norvegicus	74-95
9104891-10	1997	Serum TNF activity, however, was substantially decreased by DMTU, and this was associated with a reduced activation of nuclear factor kappaB in the peritoneal cells of LPS-treated rats.	1,3-dimethylthiourea	60-64	tumor necrosis factor-like	Rattus norvegicus	6-9
9104891-11	1997	In addition, LPS-induced TNF production in vitro by rat peritoneal macrophages was inhibited by DMTU (p < 0.05).	1,3-dimethylthiourea	96-100	tumor necrosis factor-like	Rattus norvegicus	25-28
9104891-12	1997	These results suggest that the protective effect of DMTU in gram-negative bacterial sepsis may be the result of a reduction in TNF activity.	1,3-dimethylthiourea	52-56	tumor necrosis factor-like	Rattus norvegicus	127-130